locus-tag	class	description
FOC12_RS00005	COG3403	YqcI/YcgG family
FOC12_RS00010	COG5577	PFAM Coat F domain
FOC12_RS00025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC12_RS00030	COG0574	Belongs to the PEP-utilizing enzyme family
FOC12_RS00030	COG3848	Pyruvate phosphate dikinase
FOC12_RS00045	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
FOC12_RS00075	COG1960	acyl-CoA dehydrogenase activity
FOC12_RS00085	COG0640	Transcriptional regulator
FOC12_RS00090	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOC12_RS00105	COG1414	Transcriptional regulator
FOC12_RS00110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FOC12_RS00115	COG1984	allophanate hydrolase subunit 2
FOC12_RS00145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOC12_RS00190	COG4335	DNA alkylation repair
FOC12_RS00200	COG0833	amino acid
FOC12_RS00210	COG0730	response to heat
FOC12_RS00240	COG0596	Alpha beta hydrolase
FOC12_RS00245	COG0745	RESPONSE REGULATOR receiver
FOC12_RS00250	COG0642	Histidine kinase
FOC12_RS00270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOC12_RS00290	COG0456	acetyltransferase
FOC12_RS00295	COG2207	Transcriptional regulator
FOC12_RS00320	COG0577	efflux transmembrane transporter activity
FOC12_RS00320	COG1136	(ABC) transporter
FOC12_RS00330	COG1725	Transcriptional regulator
FOC12_RS00365	COG1846	Transcriptional regulator
FOC12_RS00370	COG0778	Nitroreductase
FOC12_RS00380	COG0714	Associated with various cellular activities
FOC12_RS00405	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FOC12_RS00415	COG0753	catalase activity
FOC12_RS00420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOC12_RS00430	COG0463	Glycosyl transferase, family 2
FOC12_RS00455	COG0463	Glycosyl transferase, family 2
FOC12_RS00480	COG0714	Associated with various cellular activities
FOC12_RS00500	COG0346	lactoylglutathione lyase activity
FOC12_RS00505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC12_RS00515	COG3279	Response regulator of the LytR AlgR family
FOC12_RS00525	COG4377	Putative membrane peptidase family (DUF2324)
FOC12_RS00540	COG3655	Transcriptional regulator
FOC12_RS00550	COG1785	Belongs to the alkaline phosphatase family
FOC12_RS00555	COG3239	Fatty acid desaturase
FOC12_RS00560	COG1690	Belongs to the RtcB family
FOC12_RS00565	COG0833	amino acid
FOC12_RS00570	COG1414	Transcriptional regulator
FOC12_RS00575	COG4187	Peptidase family M20/M25/M40
FOC12_RS00580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOC12_RS00585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FOC12_RS00595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC12_RS00615	COG2329	Antibiotic biosynthesis monooxygenase
FOC12_RS00650	COG2390	Transcriptional regulator
FOC12_RS00660	COG1172	Belongs to the binding-protein-dependent transport system permease family
FOC12_RS00670	COG1879	ABC-type sugar transport system periplasmic component
FOC12_RS00695	COG1595	DNA-templated transcription, initiation
FOC12_RS00705	COG1388	LysM domain
FOC12_RS00705	COG3584	3D domain protein
FOC12_RS00740	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FOC12_RS00740	COG1605	Chorismate mutase
FOC12_RS00745	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FOC12_RS00750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FOC12_RS00755	COG0287	Prephenate dehydrogenase
FOC12_RS00770	COG1309	transcriptional regulator
FOC12_RS00775	COG2409	Drug exporters of the RND superfamily
FOC12_RS00775	COG1033	growth of symbiont in host cell
FOC12_RS00780	COG1033	growth of symbiont in host cell
FOC12_RS00780	COG2409	Drug exporters of the RND superfamily
FOC12_RS00785	COG2409	Drug exporters of the RND superfamily
FOC12_RS00785	COG1033	growth of symbiont in host cell
FOC12_RS00795	COG0488	(ABC) transporter
FOC12_RS00800	COG1368	sulfuric ester hydrolase activity
FOC12_RS00805	COG0861	Integral membrane protein TerC family
FOC12_RS00815	COG0726	polysaccharide deacetylase
FOC12_RS00825	COG4912	Dna alkylation repair
FOC12_RS00845	COG2318	DinB family
FOC12_RS00850	COG0697	spore germination
FOC12_RS00875	COG2746	aminoglycoside 3-N-acetyltransferase activity
FOC12_RS00915	COG1116	anion transmembrane transporter activity
FOC12_RS00920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FOC12_RS00925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOC12_RS00930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOC12_RS00940	COG0628	permease
FOC12_RS01000	COG5146	pantothenate kinase activity
FOC12_RS01005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FOC12_RS01010	COG0436	Aminotransferase
FOC12_RS01045	COG2226	methyltransferase
FOC12_RS01060	COG2261	transglycosylase associated protein
FOC12_RS01080	COG2814	Major facilitator Superfamily
FOC12_RS01080	COG0477	Major facilitator Superfamily
FOC12_RS01085	COG4533	DNA binding
FOC12_RS01090	COG0789	Transcriptional regulator
FOC12_RS01095	COG1664	Polymer-forming cytoskeletal
FOC12_RS01105	COG2814	Major facilitator Superfamily
FOC12_RS01125	COG1307	EDD domain protein, DegV family
FOC12_RS01140	COG1164	Oligoendopeptidase f
FOC12_RS01180	COG5002	protein histidine kinase activity
FOC12_RS01185	COG2936	dipeptidyl-peptidase activity
FOC12_RS01230	COG4948	Mandelate Racemase Muconate Lactonizing
FOC12_RS01240	COG4166	transmembrane transport
FOC12_RS01245	COG0519	Catalyzes the synthesis of GMP from XMP
FOC12_RS01250	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FOC12_RS01265	COG0586	Pfam SNARE associated Golgi protein
FOC12_RS01305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOC12_RS01310	COG3938	Belongs to the proline racemase family
FOC12_RS01320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOC12_RS01325	COG1012	belongs to the aldehyde dehydrogenase family
FOC12_RS01330	COG1115	amino acid carrier protein
FOC12_RS01335	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FOC12_RS01350	COG3397	chitin binding
FOC12_RS01375	COG4637	Psort location Cytoplasmic, score
FOC12_RS01395	COG0514	ATP-dependent DNA helicase (RecQ)
FOC12_RS01400	COG2105	PFAM AIG2 family protein
FOC12_RS01415	COG3973	AAA domain
FOC12_RS01465	COG0658	competence protein
FOC12_RS01465	COG2333	competence protein COMEC
FOC12_RS01485	COG2205	protein histidine kinase activity
FOC12_RS01500	COG3397	chitin binding
FOC12_RS01505	COG2153	protein acetylation
FOC12_RS01510	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FOC12_RS01525	COG0740	serine-type endopeptidase activity
FOC12_RS01535	COG0517	IMP dehydrogenase activity
FOC12_RS01535	COG4175	Glycine betaine
FOC12_RS01540	COG4176	ABC-type proline glycine betaine transport system permease component
FOC12_RS01570	COG0456	acetyltransferase
FOC12_RS01570	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FOC12_RS01575	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS01585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOC12_RS01590	COG0022	dehydrogenase e1 component
FOC12_RS01595	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC12_RS01600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOC12_RS01615	COG1959	2 iron, 2 sulfur cluster binding
FOC12_RS01635	COG1349	DNA-binding transcription factor activity
FOC12_RS01650	COG3284	Transcriptional regulator
FOC12_RS01680	COG1309	transcriptional regulator
FOC12_RS01685	COG3844	kynureninase activity
FOC12_RS01690	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FOC12_RS01695	COG3483	tryptophan 2,3-dioxygenase activity
FOC12_RS01710	COG3773	Cell wall hydrolase
FOC12_RS01710	COG3409	Peptidoglycan-binding domain 1 protein
FOC12_RS01715	COG2959	enzyme of heme biosynthesis
FOC12_RS01730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC12_RS01735	COG4129	membrane
FOC12_RS01765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOC12_RS01770	COG0697	spore germination
FOC12_RS01780	COG0201	protein transport
FOC12_RS01800	COG3227	Zinc metalloprotease (Elastase)
FOC12_RS01805	COG1523	belongs to the glycosyl hydrolase 13 family
FOC12_RS01820	COG0076	glutamate decarboxylase activity
FOC12_RS01840	COG1011	Hydrolase
FOC12_RS01865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOC12_RS01905	COG0322	excinuclease ABC activity
FOC12_RS01920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FOC12_RS01970	COG3878	Protein conserved in bacteria
FOC12_RS02005	COG1051	belongs to the nudix hydrolase family
FOC12_RS02010	COG0592	DNA-directed DNA polymerase activity
FOC12_RS02015	COG2816	NAD+ diphosphatase activity
FOC12_RS02030	COG2223	nitrite transmembrane transporter activity
FOC12_RS02060	COG0697	spore germination
FOC12_RS02080	COG0584	glycerophosphoryl diester phosphodiesterase
FOC12_RS02095	COG2814	Major facilitator Superfamily
FOC12_RS02125	COG0693	protein deglycase activity
FOC12_RS02160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FOC12_RS02175	COG0604	alcohol dehydrogenase
FOC12_RS02190	COG2205	protein histidine kinase activity
FOC12_RS02205	COG1122	ATPase activity
FOC12_RS02215	COG1794	racemase activity, acting on amino acids and derivatives
FOC12_RS02220	COG1819	glycosyl
FOC12_RS02230	COG5002	protein histidine kinase activity
FOC12_RS02240	COG0561	phosphatase activity
FOC12_RS02275	COG2124	cytochrome p450
FOC12_RS02340	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FOC12_RS02350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOC12_RS02355	COG0460	homoserine dehydrogenase
FOC12_RS02380	COG1136	(ABC) transporter
FOC12_RS02410	COG0745	RESPONSE REGULATOR receiver
FOC12_RS02420	COG3773	Cell wall hydrolase
FOC12_RS02445	COG1063	alcohol dehydrogenase
FOC12_RS02460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOC12_RS02480	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FOC12_RS02495	COG2814	Major facilitator Superfamily
FOC12_RS02505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FOC12_RS02520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOC12_RS02520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOC12_RS02560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FOC12_RS02585	COG1686	Belongs to the peptidase S11 family
FOC12_RS02590	COG2318	DinB family
FOC12_RS02600	COG0572	uridine kinase
FOC12_RS02605	COG1247	-acetyltransferase
FOC12_RS02615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOC12_RS02620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FOC12_RS02625	COG1024	Enoyl-CoA hydratase
FOC12_RS02630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FOC12_RS02635	COG0511	ligase activity, forming carbon-carbon bonds
FOC12_RS02640	COG0439	Biotin carboxylase
FOC12_RS02645	COG1960	acyl-CoA dehydrogenase activity
FOC12_RS02660	COG1309	transcriptional regulator
FOC12_RS02670	COG1131	(ABC) transporter
FOC12_RS02685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOC12_RS02690	COG1252	NADH dehydrogenase
FOC12_RS02705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC12_RS02725	COG1309	transcriptional regulator
FOC12_RS02745	COG1876	peptidase activity
FOC12_RS02760	COG1476	TRANSCRIPTIONal
FOC12_RS02765	COG0457	Tetratricopeptide repeat
FOC12_RS02790	COG3718	enzyme involved in inositol metabolism
FOC12_RS02810	COG1012	belongs to the aldehyde dehydrogenase family
FOC12_RS02820	COG0673	inositol 2-dehydrogenase activity
FOC12_RS02825	COG2814	Major facilitator Superfamily
FOC12_RS02830	COG1609	Transcriptional regulator
FOC12_RS02835	COG0671	phosphoesterase, PA-phosphatase related
FOC12_RS02840	COG2367	Beta-lactamase
FOC12_RS02850	COG0768	penicillin binding
FOC12_RS02860	COG1595	DNA-templated transcription, initiation
FOC12_RS02875	COG2195	Cleaves the N-terminal amino acid of tripeptides
FOC12_RS02905	COG1846	Transcriptional regulator
FOC12_RS02910	COG3961	Belongs to the TPP enzyme family
FOC12_RS02915	COG2226	methyltransferase
FOC12_RS02925	COG0500	methyltransferase
FOC12_RS02925	COG3615	Tellurite resistance protein tehB
FOC12_RS02930	COG0577	efflux transmembrane transporter activity
FOC12_RS02930	COG1136	(ABC) transporter
FOC12_RS02945	COG1309	transcriptional regulator
FOC12_RS02975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC12_RS02995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FOC12_RS03000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FOC12_RS03005	COG2971	BadF BadG BcrA BcrD
FOC12_RS03055	COG1595	DNA-templated transcription, initiation
FOC12_RS03085	COG1396	sequence-specific DNA binding
FOC12_RS03105	COG1132	(ABC) transporter
FOC12_RS03110	COG1132	(ABC) transporter
FOC12_RS03125	COG2258	MOSC domain
FOC12_RS03130	COG0583	DNA-binding transcription factor activity
FOC12_RS03145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FOC12_RS03150	COG0583	DNA-binding transcription factor activity
FOC12_RS03185	COG0561	phosphatase activity
FOC12_RS03190	COG0010	Belongs to the arginase family
FOC12_RS03205	COG1278	Cold shock
FOC12_RS03215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC12_RS03255	COG1247	-acetyltransferase
FOC12_RS03290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC12_RS03335	COG2226	methyltransferase
FOC12_RS03355	COG2814	Major facilitator Superfamily
FOC12_RS03360	COG0596	Alpha beta hydrolase
FOC12_RS03375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FOC12_RS03380	COG1187	pseudouridine synthase activity
FOC12_RS03385	COG2329	Antibiotic biosynthesis monooxygenase
FOC12_RS03400	COG1115	amino acid carrier protein
FOC12_RS03410	COG2318	DinB family
FOC12_RS03420	COG0776	regulation of translation
FOC12_RS03435	COG2814	Major facilitator Superfamily
FOC12_RS03440	COG3251	PFAM MbtH domain protein
FOC12_RS03445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOC12_RS03450	COG3433	isochorismatase activity
FOC12_RS03450	COG1535	isochorismatase
FOC12_RS03455	COG1021	2,3-dihydroxybenzoate-AMP ligase
FOC12_RS03460	COG1169	isochorismate synthase
FOC12_RS03465	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS03470	COG2223	nitrite transmembrane transporter activity
FOC12_RS03490	COG0419	ATPase involved in DNA repair
FOC12_RS03495	COG0420	3'-5' exonuclease activity
FOC12_RS03510	COG1024	Enoyl-CoA hydratase
FOC12_RS03515	COG1280	lysine exporter protein (LysE YggA)
FOC12_RS03520	COG1012	belongs to the aldehyde dehydrogenase family
FOC12_RS03525	COG2084	Dehydrogenase
FOC12_RS03530	COG1960	acyl-CoA dehydrogenase activity
FOC12_RS03535	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FOC12_RS03540	COG2079	MmgE PrpD family protein
FOC12_RS03545	COG0372	Belongs to the citrate synthase family
FOC12_RS03550	COG4841	protein insertion into membrane
FOC12_RS03555	COG2814	Major facilitator Superfamily
FOC12_RS03560	COG4499	WXG100 protein secretion system (Wss), protein YukC
FOC12_RS03560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOC12_RS03600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOC12_RS03690	COG1715	Restriction endonuclease
FOC12_RS03690	COG1787	Restriction endonuclease
FOC12_RS03720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC12_RS03725	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FOC12_RS03730	COG0671	phosphoesterase, PA-phosphatase related
FOC12_RS03735	COG4326	sporulation control protein
FOC12_RS03775	COG1509	lysine 2,3-aminomutase activity
FOC12_RS03780	COG3829	transcription factor binding
FOC12_RS03785	COG0456	acetyltransferase
FOC12_RS03790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC12_RS03795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FOC12_RS03800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FOC12_RS03805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FOC12_RS03820	COG5506	Protein of unknown function (DUF1694)
FOC12_RS03825	COG1012	belongs to the aldehyde dehydrogenase family
FOC12_RS03830	COG1253	flavin adenine dinucleotide binding
FOC12_RS03865	COG1174	glycine betaine transport
FOC12_RS03870	COG1125	glycine betaine transport
FOC12_RS03870	COG0517	IMP dehydrogenase activity
FOC12_RS03900	COG1070	Carbohydrate kinase
FOC12_RS03925	COG1064	alcohol dehydrogenase
FOC12_RS03935	COG2197	response regulator
FOC12_RS03940	COG2203	Gaf domain
FOC12_RS03940	COG4585	Histidine kinase
FOC12_RS03945	COG0668	transmembrane transport
FOC12_RS03955	COG1051	belongs to the nudix hydrolase family
FOC12_RS03980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC12_RS03985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC12_RS04000	COG0367	asparagine synthase
FOC12_RS04005	COG0071	Belongs to the small heat shock protein (HSP20) family
FOC12_RS04010	COG1999	signal sequence binding
FOC12_RS04015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FOC12_RS04020	COG1307	EDD domain protein, DegV family
FOC12_RS04030	COG0805	protein transport
FOC12_RS04040	COG1272	protein, Hemolysin III
FOC12_RS04045	COG0204	Acyl-transferase
FOC12_RS04050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FOC12_RS04055	COG0768	penicillin binding
FOC12_RS04070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FOC12_RS04090	COG0546	phosphoglycolate phosphatase activity
FOC12_RS04105	COG1131	(ABC) transporter
FOC12_RS04120	COG0456	acetyltransferase
FOC12_RS04130	COG1794	racemase activity, acting on amino acids and derivatives
FOC12_RS04135	COG1454	alcohol dehydrogenase
FOC12_RS04140	COG2610	gluconate transmembrane transporter activity
FOC12_RS04165	COG0733	neurotransmitter:sodium symporter activity
FOC12_RS04180	COG5002	protein histidine kinase activity
FOC12_RS04180	COG3850	Histidine kinase
FOC12_RS04185	COG0745	RESPONSE REGULATOR receiver
FOC12_RS04190	COG0471	metal ion transport
FOC12_RS04195	COG1929	Belongs to the glycerate kinase type-1 family
FOC12_RS04265	COG1674	ftsk spoiiie
FOC12_RS04285	COG0017	Asparaginyl-tRNA synthetase
FOC12_RS04305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FOC12_RS04330	COG0018	arginyl-trna synthetase
FOC12_RS04335	COG2136	Putative SAM-dependent methyltransferase
FOC12_RS04335	COG2521	methyltransferase
FOC12_RS04350	COG1413	lyase activity
FOC12_RS04365	COG0629	single-stranded DNA binding
FOC12_RS04380	COG0488	(ABC) transporter
FOC12_RS04385	COG1418	mRNA catabolic process
FOC12_RS04400	COG5632	N-Acetylmuramoyl-L-alanine amidase
FOC12_RS04415	COG2359	stage V sporulation protein S
FOC12_RS04450	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
FOC12_RS04455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOC12_RS04460	COG2146	nitrite reductase [NAD(P)H] activity
FOC12_RS04465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FOC12_RS04465	COG1587	Uroporphyrinogen-III synthase
FOC12_RS04475	COG1648	precorrin-2 dehydrogenase activity
FOC12_RS04490	COG2223	nitrite transmembrane transporter activity
FOC12_RS04500	COG0314	molybdopterin synthase activity
FOC12_RS04505	COG0303	'Molybdopterin
FOC12_RS04510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOC12_RS04515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FOC12_RS04520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FOC12_RS04540	COG2181	nitrate reductase activity
FOC12_RS04545	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FOC12_RS04550	COG1140	nitrate reductase beta subunit
FOC12_RS04555	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FOC12_RS04570	COG0714	Associated with various cellular activities
FOC12_RS04575	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
FOC12_RS04580	COG1305	Transglutaminase-like
FOC12_RS04585	COG0386	Belongs to the glutathione peroxidase family
FOC12_RS04610	COG1595	DNA-templated transcription, initiation
FOC12_RS04615	COG0604	alcohol dehydrogenase
FOC12_RS04625	COG0346	lactoylglutathione lyase activity
FOC12_RS04650	COG2226	methyltransferase
FOC12_RS04675	COG3874	Sporulation protein YtfJ
FOC12_RS04725	COG0456	acetyltransferase
FOC12_RS04750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOC12_RS04755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC12_RS04760	COG1819	glycosyl
FOC12_RS04780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FOC12_RS04790	COG0561	phosphatase activity
FOC12_RS04810	COG2211	Major facilitator Superfamily
FOC12_RS04815	COG0154	amidase activity
FOC12_RS04825	COG1876	peptidase activity
FOC12_RS04835	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOC12_RS04855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC12_RS04860	COG1114	Component of the transport system for branched-chain amino acids
FOC12_RS04875	COG1253	flavin adenine dinucleotide binding
FOC12_RS04880	COG2839	Protein conserved in bacteria
FOC12_RS04885	COG0702	epimerase
FOC12_RS04900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOC12_RS04910	COG1607	acyl-coa hydrolase
FOC12_RS04915	COG3689	TIGRFAM TIGR03943 family protein
FOC12_RS04920	COG0701	Predicted permease
FOC12_RS04930	COG2244	polysaccharide biosynthetic process
FOC12_RS04935	COG0586	Pfam SNARE associated Golgi protein
FOC12_RS04940	COG1051	belongs to the nudix hydrolase family
FOC12_RS04945	COG5337	Spore coat protein CotH
FOC12_RS04955	COG0406	alpha-ribazole phosphatase activity
FOC12_RS04970	COG4166	transmembrane transport
FOC12_RS04980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FOC12_RS04990	COG0702	epimerase
FOC12_RS04995	COG3443	Belongs to the bacterial solute-binding protein 9 family
FOC12_RS04995	COG0803	Belongs to the bacterial solute-binding protein 9 family
FOC12_RS05045	COG0456	acetyltransferase
FOC12_RS05050	COG0523	cobalamin synthesis protein
FOC12_RS05055	COG4989	oxidoreductase activity
FOC12_RS05065	COG1231	oxidoreductase activity
FOC12_RS05075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOC12_RS05090	COG0783	Belongs to the Dps family
FOC12_RS05095	COG3949	Membrane
FOC12_RS05110	COG0840	transmembrane signaling receptor activity
FOC12_RS05135	COG2814	Major facilitator Superfamily
FOC12_RS05140	COG0667	Aldo Keto reductase
FOC12_RS05145	COG0640	Transcriptional regulator
FOC12_RS05150	COG1404	Belongs to the peptidase S8 family
FOC12_RS05155	COG2002	toxin-antitoxin pair type II binding
FOC12_RS05195	COG1752	Esterase of the alpha-beta hydrolase superfamily
FOC12_RS05205	COG1279	arginine transmembrane transporter activity
FOC12_RS05220	COG1082	Xylose isomerase domain protein TIM barrel
FOC12_RS05235	COG0318	PFAM AMP-dependent synthetase and ligase
FOC12_RS05240	COG4264	IucA IucC family
FOC12_RS05250	COG1247	-acetyltransferase
FOC12_RS05255	COG1285	pathogenesis
FOC12_RS05265	COG0726	polysaccharide deacetylase
FOC12_RS05270	COG5002	protein histidine kinase activity
FOC12_RS05275	COG0745	RESPONSE REGULATOR receiver
FOC12_RS05285	COG1316	TRANSCRIPTIONal
FOC12_RS05310	COG0460	homoserine dehydrogenase
FOC12_RS05330	COG0726	polysaccharide deacetylase
FOC12_RS05345	COG0300	oxidoreductase activity
FOC12_RS05355	COG5002	protein histidine kinase activity
FOC12_RS05360	COG0745	RESPONSE REGULATOR receiver
FOC12_RS05375	COG1388	LysM domain
FOC12_RS05375	COG0791	NLP P60 protein
FOC12_RS05390	COG1686	Belongs to the peptidase S11 family
FOC12_RS05410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FOC12_RS05415	COG4988	ABC transporter
FOC12_RS05420	COG1294	oxidase, subunit
FOC12_RS05425	COG1271	oxidase subunit
FOC12_RS05435	COG1846	Transcriptional regulator
FOC12_RS05445	COG1942	4-Oxalocrotonate Tautomerase
FOC12_RS05455	COG0583	DNA-binding transcription factor activity
FOC12_RS05475	COG0411	ABC transporter
FOC12_RS05485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC12_RS05490	COG2030	dehydratase
FOC12_RS05495	COG0318	PFAM AMP-dependent synthetase and ligase
FOC12_RS05510	COG0523	cobalamin synthesis protein
FOC12_RS05515	COG1231	oxidoreductase activity
FOC12_RS05520	COG0039	L-malate dehydrogenase activity
FOC12_RS05525	COG0628	permease
FOC12_RS05535	COG0778	Nitroreductase
FOC12_RS05540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FOC12_RS05545	COG1959	2 iron, 2 sulfur cluster binding
FOC12_RS05550	COG0583	DNA-binding transcription factor activity
FOC12_RS05555	COG0697	spore germination
FOC12_RS05565	COG4549	nuclear export factor GLE1
FOC12_RS05570	COG2372	response to copper ion
FOC12_RS05570	COG1276	copper resistance
FOC12_RS05585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FOC12_RS05615	COG2132	Multicopper oxidase
FOC12_RS05620	COG0006	proline dipeptidase activity
FOC12_RS05640	COG4224	UPF0291 protein
FOC12_RS05655	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FOC12_RS05660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC12_RS05670	COG2390	Transcriptional regulator
FOC12_RS05700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FOC12_RS05715	COG1914	H( )-stimulated, divalent metal cation uptake system
FOC12_RS05735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC12_RS05770	COG1073	alpha beta
FOC12_RS05790	COG0427	acetyl-CoA hydrolase
FOC12_RS05795	COG3279	Response regulator of the LytR AlgR family
FOC12_RS05805	COG3384	dioxygenase
FOC12_RS05810	COG2814	Major facilitator Superfamily
FOC12_RS05835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FOC12_RS05845	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FOC12_RS05850	COG0440	acetolactate synthase activity
FOC12_RS05855	COG0028	Belongs to the TPP enzyme family
FOC12_RS05860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC12_RS05870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOC12_RS05885	COG2084	Dehydrogenase
FOC12_RS05900	COG2323	membrane
FOC12_RS05905	COG5566	PFAM Mor transcription activator
FOC12_RS05915	COG0733	neurotransmitter:sodium symporter activity
FOC12_RS05920	COG2244	polysaccharide biosynthetic process
FOC12_RS05935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOC12_RS05940	COG2223	nitrite transmembrane transporter activity
FOC12_RS05960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC12_RS05975	COG1966	Carbon starvation protein
FOC12_RS06000	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOC12_RS06005	COG1051	belongs to the nudix hydrolase family
FOC12_RS06055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOC12_RS06060	COG0784	Response regulator, receiver
FOC12_RS06065	COG4191	Histidine kinase
FOC12_RS06070	COG0281	malic enzyme
FOC12_RS06075	COG1027	Aspartate ammonia-lyase
FOC12_RS06085	COG0528	UMP kinase activity
FOC12_RS06090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOC12_RS06105	COG1131	(ABC) transporter
FOC12_RS06140	COG2733	membrane
FOC12_RS06170	COG0785	Cytochrome C biogenesis protein
FOC12_RS06190	COG3340	Belongs to the peptidase S51 family
FOC12_RS06215	COG0114	fumarate hydratase activity
FOC12_RS06220	COG1757	Na H antiporter
FOC12_RS06225	COG0438	transferase activity, transferring glycosyl groups
FOC12_RS06225	COG1216	Glycosyl transferase, family 2
FOC12_RS06235	COG0701	Predicted permease
FOC12_RS06240	COG0523	cobalamin synthesis protein
FOC12_RS06245	COG0697	spore germination
FOC12_RS06250	COG1802	Transcriptional regulator
FOC12_RS06280	COG0367	asparagine synthase
FOC12_RS06310	COG0406	alpha-ribazole phosphatase activity
FOC12_RS06320	COG1686	Belongs to the peptidase S11 family
FOC12_RS06350	COG1234	tRNA 3'-trailer cleavage
FOC12_RS06355	COG1177	transmembrane transport
FOC12_RS06360	COG0725	ABC transporter, periplasmic molybdate-binding protein
FOC12_RS06365	COG3842	ATPase activity
FOC12_RS06395	COG2329	Antibiotic biosynthesis monooxygenase
FOC12_RS06415	COG1309	transcriptional regulator
FOC12_RS06440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FOC12_RS06445	COG4786	Flagellar basal body rod
FOC12_RS06455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FOC12_RS06460	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FOC12_RS06470	COG1987	bacterial-type flagellum assembly
FOC12_RS06475	COG1338	Plays a role in the flagellum-specific transport system
FOC12_RS06485	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FOC12_RS06485	COG1776	CheC inhibitor of MCP methylation
FOC12_RS06500	COG0741	lytic transglycosylase activity
FOC12_RS06505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FOC12_RS06540	COG0463	Glycosyl transferase, family 2
FOC12_RS06590	COG1157	protein secretion by the type III secretion system
FOC12_RS06600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FOC12_RS06610	COG1677	Flagellar hook-basal body complex protein FliE
FOC12_RS06615	COG1558	bacterial-type flagellum-dependent cell motility
FOC12_RS06620	COG1815	bacterial-type flagellum-dependent cell motility
FOC12_RS06645	COG1256	bacterial-type flagellum assembly
FOC12_RS06665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FOC12_RS06680	COG1776	CheC inhibitor of MCP methylation
FOC12_RS06680	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FOC12_RS06690	COG2201	protein-glutamate methylesterase activity
FOC12_RS06695	COG1360	Flagellar Motor Protein
FOC12_RS06700	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FOC12_RS06710	COG1923	regulation of RNA biosynthetic process
FOC12_RS06765	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FOC12_RS06770	COG2323	membrane
FOC12_RS06780	COG4978	Transcriptional regulator
FOC12_RS06780	COG0789	Transcriptional regulator
FOC12_RS06790	COG0475	glutathione-regulated potassium exporter activity
FOC12_RS06800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FOC12_RS06805	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC12_RS06810	COG3162	membrane
FOC12_RS06825	COG1280	lysine exporter protein (LysE YggA)
FOC12_RS06865	COG0328	RNA-DNA hybrid ribonuclease activity
FOC12_RS06885	COG0454	-acetyltransferase
FOC12_RS06905	COG1215	transferase activity, transferring glycosyl groups
FOC12_RS06920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FOC12_RS06945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC12_RS06995	COG0456	acetyltransferase
FOC12_RS07005	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FOC12_RS07010	COG2311	Membrane
FOC12_RS07015	COG2233	PERMEase
FOC12_RS07030	COG0024	Methionine aminopeptidase
FOC12_RS07035	COG3173	Aminoglycoside phosphotransferase
FOC12_RS07045	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FOC12_RS07050	COG1199	ATP-dependent helicase activity
FOC12_RS07060	COG0116	Belongs to the methyltransferase superfamily
FOC12_RS07075	COG4474	Belongs to the UPF0398 family
FOC12_RS07115	COG4499	WXG100 protein secretion system (Wss), protein YukC
FOC12_RS07115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOC12_RS07125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FOC12_RS07130	COG3935	DnaD domain protein
FOC12_RS07150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FOC12_RS07150	COG1199	ATP-dependent helicase activity
FOC12_RS07185	COG0438	transferase activity, transferring glycosyl groups
FOC12_RS07190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FOC12_RS07205	COG1694	Mazg nucleotide pyrophosphohydrolase
FOC12_RS07210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC12_RS07220	COG2738	Putative neutral zinc metallopeptidase
FOC12_RS07235	COG4347	Protein of unknown function (DUF1405)
FOC12_RS07245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FOC12_RS07265	COG0457	Tetratricopeptide repeat
FOC12_RS07270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FOC12_RS07285	COG0105	UTP biosynthetic process
FOC12_RS07290	COG0142	geranyltranstransferase activity
FOC12_RS07300	COG0142	geranyltranstransferase activity
FOC12_RS07315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FOC12_RS07390	COG0492	ferredoxin-NADP+ reductase activity
FOC12_RS07410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FOC12_RS07415	COG4862	establishment of competence for transformation
FOC12_RS07435	COG1266	CAAX protease self-immunity
FOC12_RS07440	COG0514	ATP-dependent DNA helicase (RecQ)
FOC12_RS07445	COG4955	Helix-turn-helix domain
FOC12_RS07450	COG1141	Ferredoxin
FOC12_RS07455	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FOC12_RS07470	COG2096	Adenosyltransferase
FOC12_RS07475	COG5002	protein histidine kinase activity
FOC12_RS07480	COG0745	RESPONSE REGULATOR receiver
FOC12_RS07485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FOC12_RS07490	COG1333	cytochrome c biogenesis protein
FOC12_RS07500	COG1187	pseudouridine synthase activity
FOC12_RS07505	COG0700	Nucleoside recognition
FOC12_RS07510	COG2715	membrane protein required for spore maturation
FOC12_RS07515	COG1686	Belongs to the peptidase S11 family
FOC12_RS07520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FOC12_RS07535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FOC12_RS07535	COG0392	lysyltransferase activity
FOC12_RS07555	COG5002	protein histidine kinase activity
FOC12_RS07560	COG0582	viral genome integration into host DNA
FOC12_RS07570	COG1801	Protein of unknown function DUF72
FOC12_RS07590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOC12_RS07595	COG1392	Phosphate transport regulator
FOC12_RS07600	COG0306	phosphate transporter
FOC12_RS07605	COG0730	response to heat
FOC12_RS07620	COG1017	nitric oxide dioxygenase activity
FOC12_RS07620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FOC12_RS07645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FOC12_RS07655	COG1114	Component of the transport system for branched-chain amino acids
FOC12_RS07665	COG2197	response regulator
FOC12_RS07670	COG4585	Histidine kinase
FOC12_RS07675	COG4758	membrane
FOC12_RS07690	COG1757	Na H antiporter
FOC12_RS07710	COG0733	neurotransmitter:sodium symporter activity
FOC12_RS07715	COG1648	precorrin-2 dehydrogenase activity
FOC12_RS07735	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOC12_RS07740	COG0529	Catalyzes the synthesis of activated sulfate
FOC12_RS07760	COG0019	diaminopimelate decarboxylase activity
FOC12_RS07770	COG1368	sulfuric ester hydrolase activity
FOC12_RS07775	COG1183	phosphatidylcholine synthase activity
FOC12_RS07790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FOC12_RS07825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FOC12_RS07850	COG0473	3-isopropylmalate dehydrogenase activity
FOC12_RS07860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FOC12_RS07865	COG0440	acetolactate synthase activity
FOC12_RS07870	COG0028	Belongs to the TPP enzyme family
FOC12_RS07875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC12_RS07900	COG3874	Sporulation protein YtfJ
FOC12_RS07905	COG4709	membrane
FOC12_RS07910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FOC12_RS07915	COG1301	dicarboxylic acid transport
FOC12_RS07925	COG1846	Transcriptional regulator
FOC12_RS07940	COG1968	undecaprenyl-diphosphatase activity
FOC12_RS07945	COG0534	Mate efflux family protein
FOC12_RS07960	COG3173	Aminoglycoside phosphotransferase
FOC12_RS07970	COG0716	FMN binding
FOC12_RS07990	COG1696	Membrane protein involved in D-alanine export
FOC12_RS08000	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FOC12_RS08005	COG2070	2-Nitropropane dioxygenase
FOC12_RS08010	COG1619	proteins homologs of microcin C7 resistance protein MccF
FOC12_RS08020	COG1335	isochorismatase
FOC12_RS08030	COG1522	sequence-specific DNA binding
FOC12_RS08045	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FOC12_RS08050	COG1131	(ABC) transporter
FOC12_RS08060	COG1131	(ABC) transporter
FOC12_RS08065	COG1725	Transcriptional regulator
FOC12_RS08070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC12_RS08090	COG1780	Probably involved in ribonucleotide reductase function
FOC12_RS08115	COG4873	Protein conserved in bacteria
FOC12_RS08130	COG0720	synthase
FOC12_RS08140	COG5002	protein histidine kinase activity
FOC12_RS08145	COG2318	DinB family
FOC12_RS08155	COG1846	Transcriptional regulator
FOC12_RS08160	COG3852	Histidine kinase
FOC12_RS08170	COG2861	carbohydrate metabolic process
FOC12_RS08190	COG1349	DNA-binding transcription factor activity
FOC12_RS08205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FOC12_RS08220	COG1840	ABC-type Fe3 transport system, periplasmic component
FOC12_RS08230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FOC12_RS08240	COG3243	poly(R)-hydroxyalkanoic acid synthase
FOC12_RS08245	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS08265	COG2030	dehydratase
FOC12_RS08275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FOC12_RS08280	COG0861	Integral membrane protein TerC family
FOC12_RS08285	COG2116	formate transmembrane transporter activity
FOC12_RS08295	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FOC12_RS08315	COG2186	Transcriptional regulator
FOC12_RS08320	COG5002	protein histidine kinase activity
FOC12_RS08325	COG0745	RESPONSE REGULATOR receiver
FOC12_RS08335	COG3835	regulator
FOC12_RS08340	COG0277	FAD linked oxidase domain protein
FOC12_RS08345	COG0247	lactate metabolic process
FOC12_RS08350	COG2340	Cysteine-rich secretory protein family
FOC12_RS08360	COG0564	pseudouridine synthase activity
FOC12_RS08370	COG2409	Drug exporters of the RND superfamily
FOC12_RS08380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FOC12_RS08385	COG1177	transmembrane transport
FOC12_RS08390	COG1176	ABC-type spermidine putrescine transport system, permease component I
FOC12_RS08395	COG3842	ATPase activity
FOC12_RS08400	COG1012	belongs to the aldehyde dehydrogenase family
FOC12_RS08435	COG0681	Belongs to the peptidase S26 family
FOC12_RS08440	COG1686	Belongs to the peptidase S11 family
FOC12_RS08450	COG2226	methyltransferase
FOC12_RS08510	COG1476	TRANSCRIPTIONal
FOC12_RS08520	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC12_RS08575	COG5634	Uncharacterized conserved protein (DUF2278)
FOC12_RS08580	COG1620	l-lactate permease
FOC12_RS08615	COG0512	Glutamine amidotransferase of anthranilate synthase
FOC12_RS08615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FOC12_RS08625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC12_RS08630	COG5492	domain, Protein
FOC12_RS08645	COG2382	esterase
FOC12_RS08650	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FOC12_RS08655	COG2153	protein acetylation
FOC12_RS08700	COG1091	dTDP-4-dehydrorhamnose reductase activity
FOC12_RS08715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FOC12_RS08735	COG0463	Glycosyl transferase, family 2
FOC12_RS08735	COG0457	Tetratricopeptide repeat
FOC12_RS08755	COG1216	Glycosyl transferase, family 2
FOC12_RS08775	COG0564	pseudouridine synthase activity
FOC12_RS08780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FOC12_RS08785	COG2357	RelA SpoT domain protein
FOC12_RS08795	COG4116	CYTH
FOC12_RS08800	COG2346	COG2346, Truncated hemoglobins
FOC12_RS08810	COG1164	Oligoendopeptidase f
FOC12_RS08820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOC12_RS08825	COG4862	establishment of competence for transformation
FOC12_RS08830	COG0861	Integral membrane protein TerC family
FOC12_RS08835	COG1393	Belongs to the ArsC family
FOC12_RS08845	COG4166	transmembrane transport
FOC12_RS08850	COG0534	Mate efflux family protein
FOC12_RS08855	COG4608	Belongs to the ABC transporter superfamily
FOC12_RS08860	COG0444	Belongs to the ABC transporter superfamily
FOC12_RS08865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOC12_RS08870	COG0601	transmembrane transport
FOC12_RS08875	COG4166	transmembrane transport
FOC12_RS08885	COG0180	Tryptophanyl-tRNA synthetase
FOC12_RS08895	COG5504	Zn-dependent protease
FOC12_RS08900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOC12_RS08905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC12_RS08920	COG2267	carboxylic ester hydrolase activity
FOC12_RS08930	COG0542	response to heat
FOC12_RS08940	COG0561	phosphatase activity
FOC12_RS08955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC12_RS08965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOC12_RS08975	COG2996	Protein conserved in bacteria
FOC12_RS09000	COG0753	catalase activity
FOC12_RS09010	COG0367	asparagine synthase
FOC12_RS09035	COG0179	Fumarylacetoacetate (FAA) hydrolase
FOC12_RS09080	COG1074	ATP-dependent DNA helicase activity
FOC12_RS09085	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FOC12_RS09095	COG0398	Pfam SNARE associated Golgi protein
FOC12_RS09100	COG4903	ComK protein
FOC12_RS09115	COG1278	Cold shock
FOC12_RS09125	COG2224	Isocitrate lyase
FOC12_RS09130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FOC12_RS09135	COG0497	DNA recombination
FOC12_RS09150	COG0697	spore germination
FOC12_RS09155	COG0840	transmembrane signaling receptor activity
FOC12_RS09160	COG0501	Belongs to the peptidase M48B family
FOC12_RS09185	COG0745	RESPONSE REGULATOR receiver
FOC12_RS09190	COG2205	protein histidine kinase activity
FOC12_RS09200	COG3708	Transcriptional regulator
FOC12_RS09200	COG2207	Transcriptional regulator
FOC12_RS09205	COG1595	DNA-templated transcription, initiation
FOC12_RS09215	COG1078	dGTPase activity
FOC12_RS09250	COG3209	COG3209 Rhs family protein
FOC12_RS09280	COG0318	PFAM AMP-dependent synthetase and ligase
FOC12_RS09290	COG0095	Lipoate-protein ligase
FOC12_RS09295	COG1234	tRNA 3'-trailer cleavage
FOC12_RS09305	COG1609	Transcriptional regulator
FOC12_RS09330	COG1511	domain protein
FOC12_RS09335	COG1309	transcriptional regulator
FOC12_RS09380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FOC12_RS09385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOC12_RS09390	COG2329	Antibiotic biosynthesis monooxygenase
FOC12_RS09395	COG3428	Bacterial PH domain
FOC12_RS09400	COG3402	PFAM membrane-flanked domain
FOC12_RS09445	COG3402	PFAM membrane-flanked domain
FOC12_RS09450	COG1309	transcriptional regulator
FOC12_RS09465	COG4473	ABC transporter
FOC12_RS09470	COG1131	(ABC) transporter
FOC12_RS09475	COG0537	adenosine 5'-monophosphoramidase activity
FOC12_RS09480	COG4980	gas vesicle protein
FOC12_RS09500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOC12_RS09505	COG3973	AAA domain
FOC12_RS09515	COG0477	Major facilitator Superfamily
FOC12_RS09520	COG0477	Major facilitator Superfamily
FOC12_RS09555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FOC12_RS09565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FOC12_RS09570	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FOC12_RS09590	COG2267	carboxylic ester hydrolase activity
FOC12_RS09595	COG0457	Tetratricopeptide repeat
FOC12_RS09600	COG0346	lactoylglutathione lyase activity
FOC12_RS09605	COG0346	lactoylglutathione lyase activity
FOC12_RS09610	COG2814	Major facilitator Superfamily
FOC12_RS09615	COG1309	transcriptional regulator
FOC12_RS09640	COG0420	3'-5' exonuclease activity
FOC12_RS09670	COG0393	Putative heavy-metal-binding
FOC12_RS09690	COG2205	protein histidine kinase activity
FOC12_RS09690	COG0784	Response regulator, receiver
FOC12_RS09690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOC12_RS09690	COG2198	Histidine kinase
FOC12_RS09695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FOC12_RS09700	COG2208	phosphoserine phosphatase activity
FOC12_RS09710	COG1191	sigma factor activity
FOC12_RS09735	COG3237	CsbD-like
FOC12_RS09785	COG2770	Histidine kinase
FOC12_RS09785	COG3437	response regulator, receiver
FOC12_RS09815	COG1959	2 iron, 2 sulfur cluster binding
FOC12_RS09820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FOC12_RS09825	COG2376	Dihydroxyacetone kinase
FOC12_RS09835	COG2376	Dihydroxyacetone kinase
FOC12_RS09855	COG1183	phosphatidylcholine synthase activity
FOC12_RS09880	COG3320	Male sterility
FOC12_RS09880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOC12_RS09925	COG0477	Major facilitator Superfamily
FOC12_RS09955	COG0305	Participates in initiation and elongation during chromosome replication
FOC12_RS09970	COG0789	Transcriptional regulator
FOC12_RS09970	COG4978	Transcriptional regulator
FOC12_RS10000	COG3181	Tripartite tricarboxylate transporter family receptor
FOC12_RS10005	COG4565	transcriptional regulatory protein
FOC12_RS10010	COG3290	protein histidine kinase activity
FOC12_RS10015	COG0477	Major facilitator Superfamily
FOC12_RS10045	COG0322	excinuclease ABC activity
FOC12_RS10050	COG4608	Belongs to the ABC transporter superfamily
FOC12_RS10060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOC12_RS10065	COG0601	transmembrane transport
FOC12_RS10100	COG3938	Belongs to the proline racemase family
FOC12_RS10120	COG1363	Peptidase, m42
FOC12_RS10140	COG1024	Enoyl-CoA hydratase
FOC12_RS10155	COG1696	Membrane protein involved in D-alanine export
FOC12_RS10170	COG4196	transglutaminase domain protein
FOC12_RS10175	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOC12_RS10185	COG2244	polysaccharide biosynthetic process
FOC12_RS10190	COG0653	protein targeting
FOC12_RS10210	COG0659	secondary active sulfate transmembrane transporter activity
FOC12_RS10225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FOC12_RS10240	COG0561	phosphatase activity
FOC12_RS10255	COG3527	Alpha-acetolactate decarboxylase
FOC12_RS10260	COG0028	Belongs to the TPP enzyme family
FOC12_RS10290	COG0189	ligase activity
FOC12_RS10305	COG1126	abc transporter atp-binding protein
FOC12_RS10310	COG0765	amino acid transport
FOC12_RS10315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOC12_RS10325	COG1132	(ABC) transporter
FOC12_RS10330	COG1012	belongs to the aldehyde dehydrogenase family
FOC12_RS10340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FOC12_RS10345	COG0531	amino acid
FOC12_RS10355	COG0753	catalase activity
FOC12_RS10355	COG0693	protein deglycase activity
FOC12_RS10360	COG0693	protein deglycase activity
FOC12_RS10370	COG2211	Major facilitator Superfamily
FOC12_RS10375	COG4533	DNA binding
FOC12_RS10380	COG2249	NAD(P)H dehydrogenase (quinone) activity
FOC12_RS10390	COG1733	regulation of RNA biosynthetic process
FOC12_RS10395	COG2814	Major facilitator Superfamily
FOC12_RS10400	COG1309	transcriptional regulator
FOC12_RS10405	COG2076	Multidrug Resistance protein
FOC12_RS10410	COG2076	Multidrug Resistance protein
FOC12_RS10420	COG1522	sequence-specific DNA binding
FOC12_RS10425	COG0697	spore germination
FOC12_RS10440	COG2259	Doxx family
FOC12_RS10450	COG1263	PTS System
FOC12_RS10450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC12_RS10460	COG1737	Transcriptional regulator
FOC12_RS10470	COG0475	glutathione-regulated potassium exporter activity
FOC12_RS10475	COG0531	amino acid
FOC12_RS10505	COG0586	Pfam SNARE associated Golgi protein
FOC12_RS10540	COG3546	catalase activity
FOC12_RS10545	COG1114	Component of the transport system for branched-chain amino acids
FOC12_RS10560	COG5522	Integral membrane protein (intg_mem_TP0381)
FOC12_RS10570	COG1136	(ABC) transporter
FOC12_RS10575	COG0577	efflux transmembrane transporter activity
FOC12_RS10580	COG3584	3D domain protein
FOC12_RS10580	COG1388	LysM domain
FOC12_RS10600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FOC12_RS10605	COG1447	Phosphotransferase system cellobiose-specific component IIA
FOC12_RS10610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOC12_RS10610	COG3711	transcriptional antiterminator
FOC12_RS10625	COG1283	sodium-dependent phosphate transmembrane transporter activity
FOC12_RS10630	COG0604	alcohol dehydrogenase
FOC12_RS10635	COG1316	TRANSCRIPTIONal
FOC12_RS10645	COG0730	response to heat
FOC12_RS10650	COG2210	Belongs to the sulfur carrier protein TusA family
FOC12_RS10660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOC12_RS10665	COG0425	Belongs to the sulfur carrier protein TusA family
FOC12_RS10670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOC12_RS10670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC12_RS10675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOC12_RS10675	COG0425	Belongs to the sulfur carrier protein TusA family
FOC12_RS10680	COG1937	Protein conserved in bacteria
FOC12_RS10685	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOC12_RS10710	COG2719	SpoVR family
FOC12_RS10715	COG0778	Nitroreductase
FOC12_RS10750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FOC12_RS10755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC12_RS10765	COG1609	Transcriptional regulator
FOC12_RS10770	COG1263	PTS System
FOC12_RS10770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC12_RS10775	COG1621	beta-fructofuranosidase activity
FOC12_RS10780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOC12_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS10800	COG2252	PERMEase
FOC12_RS10815	COG1846	Transcriptional regulator
FOC12_RS10820	COG2814	Major facilitator Superfamily
FOC12_RS10825	COG2205	protein histidine kinase activity
FOC12_RS10865	COG0351	phosphomethylpyrimidine kinase
FOC12_RS10870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOC12_RS10880	COG2104	thiamine diphosphate biosynthetic process
FOC12_RS10885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOC12_RS10890	COG0352	thiamine-phosphate diphosphorylase activity
FOC12_RS10895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FOC12_RS10900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOC12_RS10905	COG1116	anion transmembrane transporter activity
FOC12_RS10910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FOC12_RS10930	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
FOC12_RS11045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FOC12_RS11055	COG0581	inorganic phosphate transmembrane transporter activity
FOC12_RS11060	COG0573	inorganic phosphate transmembrane transporter activity
FOC12_RS11065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FOC12_RS11070	COG1918	ferrous iron import across plasma membrane
FOC12_RS11070	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FOC12_RS11075	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FOC12_RS11080	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FOC12_RS11090	COG0531	amino acid
FOC12_RS11095	COG0697	spore germination
FOC12_RS11100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC12_RS11115	COG4990	cell redox homeostasis
FOC12_RS11120	COG0833	amino acid
FOC12_RS11125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FOC12_RS11130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FOC12_RS11145	COG0569	domain protein
FOC12_RS11145	COG0475	glutathione-regulated potassium exporter activity
FOC12_RS11170	COG2252	PERMEase
FOC12_RS11175	COG1113	amino acid transport
FOC12_RS11190	COG1114	Component of the transport system for branched-chain amino acids
FOC12_RS11195	COG3104	oligopeptide transport
FOC12_RS11210	COG1476	TRANSCRIPTIONal
FOC12_RS11215	COG1388	LysM domain
FOC12_RS11215	COG3584	3D domain protein
FOC12_RS11220	COG0840	transmembrane signaling receptor activity
FOC12_RS11225	COG1968	undecaprenyl-diphosphatase activity
FOC12_RS11250	COG3568	Endonuclease Exonuclease Phosphatase
FOC12_RS11265	COG1063	alcohol dehydrogenase
FOC12_RS11285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FOC12_RS11290	COG1879	ABC-type sugar transport system periplasmic component
FOC12_RS11295	COG1172	Belongs to the binding-protein-dependent transport system permease family
FOC12_RS11310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOC12_RS11315	COG1609	Transcriptional regulator
FOC12_RS11325	COG1846	Transcriptional regulator
FOC12_RS11330	COG2271	Major facilitator Superfamily
FOC12_RS11340	COG4608	Belongs to the ABC transporter superfamily
FOC12_RS11345	COG0601	transmembrane transport
FOC12_RS11355	COG0747	negative chemotaxis
FOC12_RS11370	COG0659	secondary active sulfate transmembrane transporter activity
FOC12_RS11385	COG5002	protein histidine kinase activity
FOC12_RS11390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FOC12_RS11395	COG2378	regulation of single-species biofilm formation
FOC12_RS11420	COG0833	amino acid
FOC12_RS11425	COG0765	amino acid transport
FOC12_RS11430	COG0765	amino acid transport
FOC12_RS11435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOC12_RS11440	COG1126	abc transporter atp-binding protein
FOC12_RS11445	COG1115	amino acid carrier protein
FOC12_RS11450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FOC12_RS11460	COG0697	spore germination
FOC12_RS11475	COG0366	Alpha amylase catalytic
FOC12_RS11480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC12_RS11480	COG1263	PTS System
FOC12_RS11485	COG2188	Transcriptional regulator
FOC12_RS11490	COG0531	amino acid
FOC12_RS11510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOC12_RS11515	COG0714	Associated with various cellular activities
FOC12_RS11520	COG4548	von Willebrand factor, type A
FOC12_RS11530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC12_RS11535	COG0156	8-amino-7-oxononanoate synthase activity
FOC12_RS11540	COG2226	methyltransferase
FOC12_RS11550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC12_RS11555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC12_RS11560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC12_RS11565	COG3104	oligopeptide transport
FOC12_RS11580	COG1620	l-lactate permease
FOC12_RS11585	COG1027	Aspartate ammonia-lyase
FOC12_RS11590	COG1253	flavin adenine dinucleotide binding
FOC12_RS11595	COG0346	lactoylglutathione lyase activity
FOC12_RS11600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC12_RS11605	COG1316	TRANSCRIPTIONal
FOC12_RS11610	COG2720	vancomycin resistance protein
FOC12_RS11630	COG3227	Zinc metalloprotease (Elastase)
FOC12_RS11645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FOC12_RS11650	COG2217	Heavy metal translocating P-type atpase
FOC12_RS11655	COG0640	Transcriptional regulator
FOC12_RS11660	COG0531	amino acid
FOC12_RS11675	COG2427	Protein of unknown function (DUF1641)
FOC12_RS11680	COG3383	formate dehydrogenase (NAD+) activity
FOC12_RS11685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FOC12_RS11690	COG0454	-acetyltransferase
FOC12_RS11690	COG0456	acetyltransferase
FOC12_RS11695	COG0745	RESPONSE REGULATOR receiver
FOC12_RS11700	COG5002	protein histidine kinase activity
FOC12_RS11710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOC12_RS11725	COG0281	malic enzyme
FOC12_RS11730	COG3493	citrate carrier protein
FOC12_RS11735	COG4565	transcriptional regulatory protein
FOC12_RS11740	COG3290	protein histidine kinase activity
FOC12_RS11750	COG4990	cell redox homeostasis
FOC12_RS11760	COG5002	protein histidine kinase activity
FOC12_RS11765	COG0745	RESPONSE REGULATOR receiver
FOC12_RS11770	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FOC12_RS11780	COG0395	ABC-type sugar transport system, permease component
FOC12_RS11785	COG1175	transmembrane transport
FOC12_RS11790	COG3842	ATPase activity
FOC12_RS11795	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FOC12_RS11815	COG2851	Citrate transporter
FOC12_RS11825	COG3290	protein histidine kinase activity
FOC12_RS11835	COG2268	Band 7 protein
FOC12_RS11840	COG1585	Membrane protein implicated in regulation of membrane protease activity
FOC12_RS11850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOC12_RS11870	COG2766	serine protein kinase
FOC12_RS11880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FOC12_RS11890	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FOC12_RS11900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FOC12_RS11905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FOC12_RS12020	COG0735	belongs to the Fur family
FOC12_RS12025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FOC12_RS12045	COG4555	ABC transporter
FOC12_RS12055	COG0070	glutamate synthase
FOC12_RS12055	COG0067	glutamate synthase
FOC12_RS12055	COG0069	glutamate synthase activity
FOC12_RS12060	COG4129	membrane
FOC12_RS12065	COG1132	(ABC) transporter
FOC12_RS12090	COG1194	a g-specific adenine glycosylase
FOC12_RS12095	COG1988	membrane-bound metal-dependent
FOC12_RS12125	COG1090	epimerase
FOC12_RS12130	COG1228	amidohydrolase
FOC12_RS12150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FOC12_RS12170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC12_RS12170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FOC12_RS12185	COG0463	Glycosyl transferase, family 2
FOC12_RS12200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FOC12_RS12205	COG1263	PTS System
FOC12_RS12205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC12_RS12210	COG2066	Belongs to the glutaminase family
FOC12_RS12230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC12_RS12235	COG0833	amino acid
FOC12_RS12245	COG3829	transcription factor binding
FOC12_RS12255	COG0101	tRNA pseudouridine synthase activity
FOC12_RS12460	COG1484	DNA-dependent DNA replication
FOC12_RS12495	COG1396	sequence-specific DNA binding
FOC12_RS12510	COG1396	sequence-specific DNA binding
FOC12_RS12515	COG0582	viral genome integration into host DNA
FOC12_RS12520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FOC12_RS12525	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FOC12_RS12550	COG0535	radical SAM domain protein
FOC12_RS12560	COG0387	Pfam Sodium calcium exchanger
FOC12_RS12565	COG3871	stress protein (general stress protein 26)
FOC12_RS12580	COG0586	Pfam SNARE associated Golgi protein
FOC12_RS12600	COG0697	spore germination
FOC12_RS12605	COG2217	Heavy metal translocating P-type atpase
FOC12_RS12610	COG1295	ribonuclease BN
FOC12_RS12620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC12_RS12635	COG3853	Toxic anion resistance protein (TelA)
FOC12_RS12645	COG0861	Integral membrane protein TerC family
FOC12_RS12650	COG2310	stress, protein
FOC12_RS12655	COG2310	stress, protein
FOC12_RS12660	COG2310	stress, protein
FOC12_RS12675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FOC12_RS12690	COG2270	Major facilitator Superfamily
FOC12_RS12735	COG0488	(ABC) transporter
FOC12_RS12740	COG1116	anion transmembrane transporter activity
FOC12_RS12750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOC12_RS12765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FOC12_RS12795	COG1263	PTS System
FOC12_RS12795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC12_RS12795	COG2190	(PTS) system
FOC12_RS12800	COG0366	Alpha amylase catalytic
FOC12_RS12805	COG0840	transmembrane signaling receptor activity
FOC12_RS12810	COG0840	transmembrane signaling receptor activity
FOC12_RS12820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOC12_RS12825	COG0765	amino acid transport
FOC12_RS12835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOC12_RS12835	COG0723	plastoquinol--plastocyanin reductase activity
FOC12_RS12840	COG2814	Major facilitator Superfamily
FOC12_RS12845	COG3541	Predicted nucleotidyltransferase
FOC12_RS12865	COG5002	protein histidine kinase activity
FOC12_RS12900	COG0166	Belongs to the GPI family
FOC12_RS12915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC12_RS12920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC12_RS12925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC12_RS12930	COG0235	Class ii aldolase
FOC12_RS12940	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
FOC12_RS12945	COG0450	alkyl hydroperoxide reductase
FOC12_RS12960	COG1473	amidohydrolase
FOC12_RS12990	COG4807	Protein conserved in bacteria
FOC12_RS13000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FOC12_RS13005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FOC12_RS13010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC12_RS13025	COG2309	aminopeptidase activity
FOC12_RS13030	COG2076	Multidrug Resistance protein
FOC12_RS13035	COG1012	belongs to the aldehyde dehydrogenase family
FOC12_RS13045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FOC12_RS13050	COG0546	phosphoglycolate phosphatase activity
FOC12_RS13055	COG1597	lipid kinase activity
FOC12_RS13080	COG1846	Transcriptional regulator
FOC12_RS13100	COG1464	Belongs to the NlpA lipoprotein family
FOC12_RS13105	COG2011	ABC-type metal ion transport system permease component
FOC12_RS13110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOC12_RS13115	COG1335	isochorismatase
FOC12_RS13130	COG4851	CamS sex pheromone cAM373 precursor
FOC12_RS13140	COG0210	DNA helicase
FOC12_RS13165	COG0151	Belongs to the GarS family
FOC12_RS13175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FOC12_RS13185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FOC12_RS13200	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOC12_RS13210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FOC12_RS13215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FOC12_RS13220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FOC12_RS13240	COG0745	RESPONSE REGULATOR receiver
FOC12_RS13245	COG2205	protein histidine kinase activity
FOC12_RS13260	COG1968	undecaprenyl-diphosphatase activity
FOC12_RS13300	COG2226	methyltransferase
FOC12_RS13335	COG5002	protein histidine kinase activity
FOC12_RS13345	COG2252	PERMEase
FOC12_RS13365	COG1266	CAAX protease self-immunity
FOC12_RS13380	COG0488	(ABC) transporter
FOC12_RS13385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FOC12_RS13390	COG0456	acetyltransferase
FOC12_RS13395	COG1214	PFAM Peptidase M22, glycoprotease
FOC12_RS13400	COG0802	atpase or kinase
FOC12_RS13495	COG2183	response to ionizing radiation
FOC12_RS13500	COG2337	Toxic component of a toxin-antitoxin (TA) module
FOC12_RS13505	COG0864	Transcriptional regulator
FOC12_RS13510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FOC12_RS13515	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FOC12_RS13525	COG0705	Rhomboid family
FOC12_RS13525	COG0457	Tetratricopeptide repeat
FOC12_RS13530	COG4294	response to UV
FOC12_RS13540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FOC12_RS13550	COG2814	Major facilitator Superfamily
FOC12_RS13560	COG0179	Fumarylacetoacetate (FAA) hydrolase
FOC12_RS13565	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FOC12_RS13585	COG4608	Belongs to the ABC transporter superfamily
FOC12_RS13590	COG0444	Belongs to the ABC transporter superfamily
FOC12_RS13600	COG0601	transmembrane transport
FOC12_RS13605	COG0747	negative chemotaxis
FOC12_RS13620	COG0488	(ABC) transporter
FOC12_RS13640	COG5298	Protein conserved in bacteria
FOC12_RS13645	COG0084	hydrolase, TatD family'
FOC12_RS13655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC12_RS13665	COG1609	Transcriptional regulator
FOC12_RS13675	COG0204	Acyl-transferase
FOC12_RS13690	COG0697	spore germination
FOC12_RS13695	COG0583	DNA-binding transcription factor activity
FOC12_RS13705	COG1910	domain protein
FOC12_RS13715	COG4149	molybdate abc transporter
FOC12_RS13720	COG4975	Glucose uptake
FOC12_RS13730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOC12_RS13735	COG0656	L-ascorbic acid biosynthetic process
FOC12_RS13740	COG4166	transmembrane transport
FOC12_RS13745	COG4166	transmembrane transport
FOC12_RS13760	COG2207	Transcriptional regulator
FOC12_RS13770	COG4166	transmembrane transport
FOC12_RS13775	COG4608	Belongs to the ABC transporter superfamily
FOC12_RS13780	COG0444	Belongs to the ABC transporter superfamily
FOC12_RS13785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOC12_RS13790	COG0601	transmembrane transport
FOC12_RS13805	COG2814	Major facilitator Superfamily
FOC12_RS13815	COG2271	Major facilitator Superfamily
FOC12_RS13820	COG0277	FAD linked oxidase domain protein
FOC12_RS13835	COG1464	Belongs to the NlpA lipoprotein family
FOC12_RS13840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOC12_RS13845	COG2011	ABC-type metal ion transport system permease component
FOC12_RS13880	COG4946	Tricorn protease homolog
FOC12_RS13880	COG1506	peptidase
FOC12_RS13880	COG0823	Involved in the tonB-independent uptake of proteins
FOC12_RS13885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FOC12_RS13905	COG0596	Alpha beta hydrolase
FOC12_RS13910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FOC12_RS13925	COG4856	YbbR-like protein
FOC12_RS13930	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FOC12_RS14010	COG0726	polysaccharide deacetylase
FOC12_RS14015	COG2194	sulfuric ester hydrolase activity
FOC12_RS14025	COG0489	protein tyrosine kinase activity
FOC12_RS14030	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOC12_RS14050	COG0101	tRNA pseudouridine synthase activity
FOC12_RS14055	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FOC12_RS14060	COG1122	ATPase activity
FOC12_RS14090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FOC12_RS14100	COG0024	Methionine aminopeptidase
FOC12_RS14110	COG0201	protein transport
FOC12_RS14135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FOC12_RS14240	COG1358	cellular component organization or biogenesis
FOC12_RS14245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FOC12_RS14255	COG2813	Specifically methylates the guanine in position
FOC12_RS14280	COG0250	Participates in transcription elongation, termination and antitermination
FOC12_RS14285	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOC12_RS14290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FOC12_RS14300	COG3688	RNA-binding protein containing a PIN domain
FOC12_RS14305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOC12_RS14320	COG1045	serine acetyltransferase
FOC12_RS14340	COG4956	integral membrane protein (PIN domain superfamily)
FOC12_RS14350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FOC12_RS14355	COG0542	response to heat
FOC12_RS14365	COG3880	PFAM UvrB UvrC protein
FOC12_RS14395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FOC12_RS14400	COG1396	sequence-specific DNA binding
FOC12_RS14405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FOC12_RS14410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FOC12_RS14415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FOC12_RS14420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC12_RS14425	COG0512	Glutamine amidotransferase of anthranilate synthase
FOC12_RS14430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOC12_RS14435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOC12_RS14450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOC12_RS14460	COG0037	tRNA processing
FOC12_RS14465	COG2208	phosphoserine phosphatase activity
FOC12_RS14480	COG1098	S1 RNA binding domain
FOC12_RS14500	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FOC12_RS14505	COG3956	TIGRFAM MazG family protein
FOC12_RS14510	COG2244	polysaccharide biosynthetic process
FOC12_RS14515	COG2002	toxin-antitoxin pair type II binding
FOC12_RS14520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FOC12_RS14530	COG0193	aminoacyl-tRNA hydrolase activity
FOC12_RS14535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FOC12_RS14550	COG0251	oxidation-reduction process
FOC12_RS14555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOC12_RS14570	COG4466	Protein conserved in bacteria
FOC12_RS14585	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FOC12_RS14590	COG0084	hydrolase, TatD family'
FOC12_RS14595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC12_RS14595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC12_RS14600	COG2002	toxin-antitoxin pair type II binding
FOC12_RS14605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FOC12_RS14615	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FOC12_RS14625	COG1774	PSP1 C-terminal conserved region
FOC12_RS14630	COG0470	DNA polymerase III
FOC12_RS14640	COG1982	Orn Lys Arg decarboxylase major
FOC12_RS14695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FOC12_RS14705	COG0590	tRNA wobble adenosine to inosine editing
FOC12_RS14710	COG1335	isochorismatase
FOC12_RS14715	COG1428	Deoxynucleoside kinase
FOC12_RS14720	COG1428	Deoxynucleoside kinase
FOC12_RS14750	COG1686	Belongs to the peptidase S11 family
FOC12_RS14755	COG0516	GMP reductase activity
FOC12_RS14755	COG0517	IMP dehydrogenase activity
FOC12_RS14790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOC12_RS14795	COG0187	DNA topoisomerase II activity
FOC12_RS14805	COG2501	S4 domain
FOC12_RS14810	COG0592	DNA-directed DNA polymerase activity
FOC12_RS14830	COG0706	membrane insertase activity
FOC12_RS14835	COG1847	R3H domain protein
FOC12_RS14840	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FOC12_RS14860	COG1192	Involved in chromosome partitioning
FOC12_RS14865	COG1475	DNA binding
FOC12_RS14875	COG0668	transmembrane transport
FOC12_RS14880	COG4481	Protein conserved in bacteria
FOC12_RS14885	COG0012	GTP binding
FOC12_RS14895	COG0629	single-stranded DNA binding
FOC12_RS14905	COG4241	membrane
FOC12_RS14910	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FOC12_RS14920	COG0305	Participates in initiation and elongation during chromosome replication
FOC12_RS14950	COG0745	RESPONSE REGULATOR receiver
FOC12_RS14955	COG5002	protein histidine kinase activity
FOC12_RS14960	COG4863	YycH protein
FOC12_RS14965	COG4853	Protein conserved in bacteria
FOC12_RS14970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FOC12_RS14975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC12_RS14995	COG1164	Oligoendopeptidase f
FOC12_RS15000	COG0516	GMP reductase activity
FOC12_RS15020	COG1272	protein, Hemolysin III
FOC12_RS15025	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FOC12_RS15045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FOC12_RS15050	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
FOC12_RS15055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOC12_RS15060	COG2814	Major facilitator Superfamily
FOC12_RS15065	COG3275	phosphorelay sensor kinase activity
FOC12_RS15070	COG3279	Response regulator of the LytR AlgR family
FOC12_RS15085	COG0628	permease
FOC12_RS15090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOC12_RS15090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOC12_RS15095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FOC12_RS15100	COG1309	transcriptional regulator
FOC12_RS15105	COG0463	Glycosyl transferase, family 2
FOC12_RS15125	COG0488	(ABC) transporter
FOC12_RS15140	COG1607	acyl-coa hydrolase
FOC12_RS15150	COG0840	transmembrane signaling receptor activity
FOC12_RS15175	COG0477	Major facilitator Superfamily
FOC12_RS15180	COG3279	Response regulator of the LytR AlgR family
FOC12_RS15185	COG1966	Carbon starvation protein
FOC12_RS15190	COG2879	small protein
FOC12_RS15195	COG3706	GGDEF domain
FOC12_RS15200	COG0351	phosphomethylpyrimidine kinase
FOC12_RS15210	COG2197	response regulator
FOC12_RS15220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FOC12_RS15225	COG1011	Hydrolase
FOC12_RS15245	COG0460	homoserine dehydrogenase
FOC12_RS15255	COG1609	Transcriptional regulator
FOC12_RS15260	COG2755	lipolytic protein G-D-S-L family
FOC12_RS15265	COG1131	(ABC) transporter
FOC12_RS15270	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FOC12_RS15280	COG2814	Major facilitator Superfamily
FOC12_RS15285	COG0561	phosphatase activity
FOC12_RS15290	COG2233	PERMEase
FOC12_RS15305	COG2363	Small membrane protein
FOC12_RS15315	COG3773	Cell wall hydrolase
FOC12_RS15330	COG0280	phosphate acetyltransferase
FOC12_RS15335	COG0095	Lipoate-protein ligase
FOC12_RS15360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC12_RS15365	COG1120	ATPase activity
FOC12_RS15370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC12_RS15375	COG1078	dGTPase activity
FOC12_RS15385	COG1994	Peptidase M50
FOC12_RS15395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOC12_RS15400	COG0584	glycerophosphoryl diester phosphodiesterase
FOC12_RS15405	COG0789	Transcriptional regulator
FOC12_RS15410	COG2814	Major facilitator Superfamily
FOC12_RS15415	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FOC12_RS15420	COG0010	Belongs to the arginase family
FOC12_RS15435	COG1619	proteins homologs of microcin C7 resistance protein MccF
FOC12_RS15440	COG4506	Protein conserved in bacteria
FOC12_RS15445	COG0018	arginyl-trna synthetase
FOC12_RS15450	COG1595	DNA-templated transcription, initiation
FOC12_RS15470	COG2234	aminopeptidase activity
FOC12_RS15480	COG0024	Methionine aminopeptidase
FOC12_RS15485	COG1131	(ABC) transporter
FOC12_RS15490	COG0842	Transport permease protein
FOC12_RS15495	COG4585	Histidine kinase
FOC12_RS15500	COG2197	response regulator
FOC12_RS15525	COG5001	Diguanylate cyclase
FOC12_RS15525	COG3300	MHYT domain
FOC12_RS15535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOC12_RS15540	COG0247	lactate metabolic process
FOC12_RS15540	COG2181	nitrate reductase activity
FOC12_RS15545	COG0183	Belongs to the thiolase family
FOC12_RS15550	COG1250	3-hydroxyacyl-CoA dehydrogenase
FOC12_RS15555	COG1960	acyl-CoA dehydrogenase activity
FOC12_RS15560	COG1960	acyl-CoA dehydrogenase activity
FOC12_RS15570	COG3343	RNA polymerase activity
FOC12_RS15580	COG4821	SIS domain
FOC12_RS15595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FOC12_RS15600	COG1494	fructose-1,6-bisphosphatase
FOC12_RS15605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FOC12_RS15620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FOC12_RS15625	COG2890	protein-(glutamine-N5) methyltransferase activity
FOC12_RS15640	COG0009	L-threonylcarbamoyladenylate synthase
FOC12_RS15655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FOC12_RS15660	COG2259	Doxx family
FOC12_RS15665	COG2190	(PTS) system
FOC12_RS15675	COG0698	ribose 5-phosphate isomerase
FOC12_RS15710	COG0356	it plays a direct role in the translocation of protons across the membrane
FOC12_RS15760	COG5001	Diguanylate cyclase
FOC12_RS15760	COG3300	MHYT domain
FOC12_RS15765	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOC12_RS15775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOC12_RS15780	COG0649	NAD binding
FOC12_RS15795	COG0839	Belongs to the complex I subunit 6 family
FOC12_RS15805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC12_RS15810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOC12_RS15815	COG1007	ATP synthesis coupled electron transport
FOC12_RS15820	COG4836	Membrane
FOC12_RS15830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FOC12_RS15835	COG2385	sporulation resulting in formation of a cellular spore
FOC12_RS15840	COG4555	ABC transporter
FOC12_RS15845	COG3279	Response regulator of the LytR AlgR family
FOC12_RS15860	COG0739	heme binding
FOC12_RS15875	COG1609	Transcriptional regulator
FOC12_RS15920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FOC12_RS15925	COG1682	transport, permease protein
FOC12_RS15930	COG1134	teichoic acid transport
FOC12_RS15935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FOC12_RS15950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FOC12_RS15955	COG0745	RESPONSE REGULATOR receiver
FOC12_RS15960	COG5002	protein histidine kinase activity
FOC12_RS15995	COG1136	(ABC) transporter
FOC12_RS16000	COG0577	efflux transmembrane transporter activity
FOC12_RS16010	COG1191	sigma factor activity
FOC12_RS16040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOC12_RS16045	COG4715	Zinc finger, swim domain protein
FOC12_RS16070	COG3584	3D domain protein
FOC12_RS16070	COG1388	LysM domain
FOC12_RS16075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOC12_RS16090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC12_RS16105	COG1368	sulfuric ester hydrolase activity
FOC12_RS16115	COG2389	metal-binding protein
FOC12_RS16125	COG1620	l-lactate permease
FOC12_RS16135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FOC12_RS16140	COG1294	oxidase, subunit
FOC12_RS16145	COG1271	oxidase subunit
FOC12_RS16160	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FOC12_RS16165	COG0583	DNA-binding transcription factor activity
FOC12_RS16170	COG1511	domain protein
FOC12_RS16175	COG0346	lactoylglutathione lyase activity
FOC12_RS16185	COG1301	dicarboxylic acid transport
FOC12_RS16190	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FOC12_RS16200	COG1447	Phosphotransferase system cellobiose-specific component IIA
FOC12_RS16205	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FOC12_RS16210	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FOC12_RS16220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FOC12_RS16225	COG1447	Phosphotransferase system cellobiose-specific component IIA
FOC12_RS16230	COG1486	melibiose metabolic process
FOC12_RS16235	COG3394	polysaccharide catabolic process
FOC12_RS16250	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FOC12_RS16250	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FOC12_RS16260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOC12_RS16265	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FOC12_RS16270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FOC12_RS16275	COG1316	TRANSCRIPTIONal
FOC12_RS16280	COG1739	Uncharacterized protein family UPF0029
FOC12_RS16285	COG1307	EDD domain protein, DegV family
FOC12_RS16290	COG1733	regulation of RNA biosynthetic process
FOC12_RS16295	COG0791	NLP P60 protein
FOC12_RS16295	COG1388	LysM domain
FOC12_RS16300	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FOC12_RS16305	COG1040	competence protein
FOC12_RS16310	COG1278	Cold shock
FOC12_RS16315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FOC12_RS16320	COG0653	protein targeting
FOC12_RS16340	COG2884	Cell division ATP-binding protein ftsE
FOC12_RS16345	COG2177	Part of the ABC transporter FtsEX involved in
FOC12_RS16350	COG0793	Belongs to the peptidase S41A family
FOC12_RS16350	COG3409	Peptidoglycan-binding domain 1 protein
FOC12_RS16355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC12_RS16360	COG1132	(ABC) transporter
FOC12_RS16375	COG0655	NAD(P)H dehydrogenase (quinone) activity
FOC12_RS16385	COG0583	DNA-binding transcription factor activity
FOC12_RS16390	COG2855	membrane
FOC12_RS16415	COG0789	Transcriptional regulator
FOC12_RS16435	COG0556	nucleotide-excision repair
FOC12_RS16440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOC12_RS16450	COG1950	PFAM Membrane protein of
FOC12_RS16470	COG0110	maltose O-acetyltransferase activity
FOC12_RS16475	COG0457	Tetratricopeptide repeat
FOC12_RS16480	COG0492	ferredoxin-NADP+ reductase activity
FOC12_RS16490	COG1051	belongs to the nudix hydrolase family
FOC12_RS16500	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FOC12_RS16510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOC12_RS16515	COG0740	serine-type endopeptidase activity
FOC12_RS16520	COG2323	membrane
FOC12_RS16535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC12_RS16560	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FOC12_RS16575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FOC12_RS16585	COG0149	triose-phosphate isomerase activity
FOC12_RS16590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FOC12_RS16600	COG4974	Belongs to the 'phage' integrase family
FOC12_RS16625	COG4695	Portal protein
FOC12_RS16720	COG1346	cytolysis
FOC12_RS16725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOC12_RS16730	COG1647	Serine aminopeptidase, S33
FOC12_RS16735	COG0557	exoribonuclease II activity
FOC12_RS16785	COG3223	Belongs to the PsiE family
FOC12_RS16790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC12_RS16805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOC12_RS16810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOC12_RS16820	COG3290	protein histidine kinase activity
FOC12_RS16820	COG0840	transmembrane signaling receptor activity
FOC12_RS16830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FOC12_RS16835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FOC12_RS16840	COG1252	NADH dehydrogenase
FOC12_RS16850	COG1733	regulation of RNA biosynthetic process
FOC12_RS16855	COG2814	Major facilitator Superfamily
FOC12_RS16860	COG0656	L-ascorbic acid biosynthetic process
FOC12_RS16875	COG2910	NAD(P)H-binding
FOC12_RS16880	COG1115	amino acid carrier protein
FOC12_RS16885	COG1115	amino acid carrier protein
FOC12_RS16890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC12_RS16895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC12_RS16915	COG1611	Belongs to the LOG family
FOC12_RS16930	COG0783	Belongs to the Dps family
FOC12_RS16935	COG1115	amino acid carrier protein
FOC12_RS16940	COG0490	domain, Protein
FOC12_RS16945	COG0475	glutathione-regulated potassium exporter activity
FOC12_RS16960	COG1741	Belongs to the pirin family
FOC12_RS16965	COG3227	Zinc metalloprotease (Elastase)
FOC12_RS16970	COG2151	metal-sulfur cluster biosynthetic enzyme
FOC12_RS16985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC12_RS16995	COG5002	protein histidine kinase activity
FOC12_RS17000	COG0745	RESPONSE REGULATOR receiver
FOC12_RS17005	COG1376	ErfK ybiS ycfS ynhG family protein
FOC12_RS17015	COG0586	Pfam SNARE associated Golgi protein
FOC12_RS17050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC12_RS17060	COG0706	membrane insertase activity
FOC12_RS17070	COG0531	amino acid
FOC12_RS17075	COG2814	Major facilitator Superfamily
FOC12_RS17090	COG0840	transmembrane signaling receptor activity
FOC12_RS17095	COG0011	TIGRFAM Protein of
FOC12_RS17110	COG1686	Belongs to the peptidase S11 family
FOC12_RS17120	COG1024	Enoyl-CoA hydratase
FOC12_RS17120	COG1250	3-hydroxyacyl-CoA dehydrogenase
FOC12_RS17125	COG0183	Belongs to the thiolase family
FOC12_RS17130	COG1960	acyl-CoA dehydrogenase activity
FOC12_RS17135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC12_RS17140	COG1309	transcriptional regulator
FOC12_RS17160	COG0039	L-malate dehydrogenase activity
FOC12_RS17205	COG1393	Belongs to the ArsC family
FOC12_RS17220	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FOC12_RS17225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC12_RS17235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOC12_RS17240	COG2011	ABC-type metal ion transport system permease component
FOC12_RS17245	COG1464	Belongs to the NlpA lipoprotein family
FOC12_RS17250	COG1464	Belongs to the NlpA lipoprotein family
FOC12_RS17255	COG0396	ATPase activity
FOC12_RS17260	COG0719	Fe-S assembly protein
FOC12_RS17265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FOC12_RS17270	COG0822	iron-sulfur transferase activity
FOC12_RS17275	COG0719	Fe-S assembly protein
FOC12_RS17285	COG1695	Transcriptional regulator
FOC12_RS17290	COG0737	Belongs to the 5'-nucleotidase family
FOC12_RS17295	COG3377	Domain of unknown function (DUF1805)
FOC12_RS17305	COG0739	heme binding
FOC12_RS17330	COG4377	Putative membrane peptidase family (DUF2324)
FOC12_RS17335	COG0789	Transcriptional regulator
FOC12_RS17345	COG4470	Protein conserved in bacteria
FOC12_RS17360	COG1494	fructose-1,6-bisphosphatase
FOC12_RS17365	COG2445	Protein of unknown function DUF86
FOC12_RS17375	COG0647	UMP catabolic process
FOC12_RS17380	COG2249	NAD(P)H dehydrogenase (quinone) activity
FOC12_RS17390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FOC12_RS17395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FOC12_RS17405	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FOC12_RS17410	COG4837	Protein of unknown function (DUF1462)
FOC12_RS17450	COG2824	Alkylphosphonate utilization operon protein PhnA
FOC12_RS17455	COG0390	transport system, permease component
FOC12_RS17470	COG1252	NADH dehydrogenase
FOC12_RS17485	COG0316	Belongs to the HesB IscA family
FOC12_RS17505	COG1683	Conserved Protein
FOC12_RS17520	COG3708	Transcriptional regulator
FOC12_RS17535	COG1252	NADH dehydrogenase
FOC12_RS17550	COG3584	3D domain protein
FOC12_RS17565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOC12_RS17570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FOC12_RS17580	COG1268	BioY protein
FOC12_RS17590	COG2050	protein possibly involved in aromatic compounds catabolism
FOC12_RS17595	COG0423	glycine-tRNA ligase activity
FOC12_RS17610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FOC12_RS17615	COG5018	Exonuclease
FOC12_RS17630	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FOC12_RS17640	COG2267	carboxylic ester hydrolase activity
FOC12_RS17645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOC12_RS17650	COG1522	sequence-specific DNA binding
FOC12_RS17655	COG0436	Aminotransferase
FOC12_RS17660	COG1098	S1 RNA binding domain
FOC12_RS17665	COG2155	Conserved Protein
FOC12_RS17670	COG0166	Belongs to the GPI family
FOC12_RS17680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FOC12_RS17685	COG1285	pathogenesis
FOC12_RS17720	COG0544	peptidyl-prolyl cis-trans isomerase activity
FOC12_RS17815	COG0039	L-malate dehydrogenase activity
FOC12_RS17835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FOC12_RS17840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FOC12_RS17845	COG0297	glycogen (starch) synthase activity
FOC12_RS17850	COG0058	SHG alpha-glucan phosphorylase activity
FOC12_RS17865	COG1278	Cold shock
FOC12_RS17870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FOC12_RS17875	COG1575	Belongs to the MenA family. Type 1 subfamily
FOC12_RS17880	COG1169	isochorismate synthase
FOC12_RS17885	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FOC12_RS17890	COG0596	Alpha beta hydrolase
FOC12_RS17895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FOC12_RS17905	COG4948	Mandelate Racemase Muconate Lactonizing
FOC12_RS17935	COG3964	amidohydrolase
FOC12_RS17975	COG1136	(ABC) transporter
FOC12_RS17980	COG0577	efflux transmembrane transporter activity
FOC12_RS17990	COG2205	protein histidine kinase activity
FOC12_RS17995	COG0745	RESPONSE REGULATOR receiver
FOC12_RS18000	COG2207	Transcriptional regulator
FOC12_RS18000	COG3708	Transcriptional regulator
FOC12_RS18005	COG1136	(ABC) transporter
FOC12_RS18010	COG0577	efflux transmembrane transporter activity
FOC12_RS18020	COG0586	Pfam SNARE associated Golgi protein
FOC12_RS18055	COG1597	lipid kinase activity
FOC12_RS18085	COG0745	RESPONSE REGULATOR receiver
FOC12_RS18090	COG5002	protein histidine kinase activity
FOC12_RS18125	COG1842	Phage shock protein A
FOC12_RS18150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC12_RS18170	COG1294	oxidase, subunit
FOC12_RS18175	COG1271	oxidase subunit
FOC12_RS18180	COG0288	reversible hydration of carbon dioxide
FOC12_RS18210	COG0494	nUDIX hydrolase
FOC12_RS18235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOC12_RS18240	COG1116	anion transmembrane transporter activity
FOC12_RS18245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FOC12_RS18265	COG2267	carboxylic ester hydrolase activity
FOC12_RS18270	COG4191	Histidine kinase
FOC12_RS18275	COG5002	protein histidine kinase activity
FOC12_RS18280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FOC12_RS18330	COG0521	Mo-molybdopterin cofactor biosynthetic process
FOC12_RS18340	COG0438	transferase activity, transferring glycosyl groups
FOC12_RS18345	COG0671	phosphoesterase, PA-phosphatase related
FOC12_RS18350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FOC12_RS18355	COG2267	carboxylic ester hydrolase activity
FOC12_RS18375	COG1794	racemase activity, acting on amino acids and derivatives
FOC12_RS18385	COG1131	(ABC) transporter
FOC12_RS18390	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FOC12_RS18395	COG1242	4 iron, 4 sulfur cluster binding
FOC12_RS18415	COG1136	(ABC) transporter
FOC12_RS18425	COG0582	viral genome integration into host DNA
FOC12_RS18430	COG0490	domain, Protein
FOC12_RS18435	COG0475	glutathione-regulated potassium exporter activity
FOC12_RS18440	COG2814	Major facilitator Superfamily
FOC12_RS18480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOC12_RS18490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOC12_RS18515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOC12_RS18525	COG0303	'Molybdopterin
FOC12_RS18530	COG1763	Mo-molybdopterin cofactor biosynthetic process
FOC12_RS18535	COG0314	molybdopterin synthase activity
FOC12_RS18550	COG4975	Glucose uptake
FOC12_RS18560	COG1329	Transcriptional regulator
FOC12_RS18580	COG3832	glyoxalase III activity
FOC12_RS18590	COG2814	Major facilitator Superfamily
FOC12_RS18595	COG2081	HI0933 family
FOC12_RS18600	COG2244	polysaccharide biosynthetic process
FOC12_RS18605	COG1187	pseudouridine synthase activity
FOC12_RS18610	COG1349	DNA-binding transcription factor activity
FOC12_RS18625	COG1523	belongs to the glycosyl hydrolase 13 family
FOC12_RS18630	COG0510	thiamine kinase activity
FOC12_RS18645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC12_RS18655	COG1363	Peptidase, m42
FOC12_RS18660	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FOC12_RS18665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC12_RS18670	COG4848	Belongs to the UPF0354 family
FOC12_RS18675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC12_RS18685	COG1674	ftsk spoiiie
FOC12_RS18700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC12_RS18720	COG2309	aminopeptidase activity
FOC12_RS18730	COG3118	belongs to the thioredoxin family
FOC12_RS18735	COG4851	CamS sex pheromone cAM373 precursor
FOC12_RS18740	COG1609	Transcriptional regulator
FOC12_RS18775	COG0666	response to abiotic stimulus
FOC12_RS18785	COG0745	RESPONSE REGULATOR receiver
FOC12_RS18795	COG0123	including yeast histone deacetylase and acetoin utilization protein
FOC12_RS18800	COG0517	IMP dehydrogenase activity
FOC12_RS18805	COG0454	-acetyltransferase
FOC12_RS18810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOC12_RS18825	COG1595	DNA-templated transcription, initiation
FOC12_RS18835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FOC12_RS18855	COG0626	cystathionine gamma-synthase activity
FOC12_RS18860	COG1956	GAF domain-containing protein
FOC12_RS18870	COG0697	spore germination
FOC12_RS18875	COG0583	DNA-binding transcription factor activity
FOC12_RS18885	COG1104	cysteine desulfurase activity
FOC12_RS18900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOC12_RS18910	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FOC12_RS18915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FOC12_RS18925	COG3874	Sporulation protein YtfJ
FOC12_RS18930	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FOC12_RS18935	COG0827	DNA restriction-modification system
FOC12_RS18940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FOC12_RS18960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC12_RS19000	COG0589	response to stress
FOC12_RS19005	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS19020	COG1476	TRANSCRIPTIONal
FOC12_RS19030	COG0662	Cupin 2, conserved barrel domain protein
FOC12_RS19035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC12_RS19070	COG0006	proline dipeptidase activity
FOC12_RS19085	COG4109	DRTGG domain
FOC12_RS19105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FOC12_RS19120	COG0587	DNA-directed DNA polymerase activity
FOC12_RS19125	COG0281	malic enzyme
FOC12_RS19130	COG1725	Transcriptional regulator
FOC12_RS19155	COG3030	protein affecting phage T7 exclusion by the F plasmid
FOC12_RS19160	COG0628	permease
FOC12_RS19170	COG0372	Belongs to the citrate synthase family
FOC12_RS19175	COG0538	isocitrate dehydrogenase activity
FOC12_RS19190	COG0745	RESPONSE REGULATOR receiver
FOC12_RS19195	COG5002	protein histidine kinase activity
FOC12_RS19200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC12_RS19200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC12_RS19205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FOC12_RS19210	COG1971	Probably functions as a manganese efflux pump
FOC12_RS19215	COG0237	dephospho-CoA kinase activity
FOC12_RS19220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FOC12_RS19230	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FOC12_RS19240	COG3611	Membrane attachment protein
FOC12_RS19245	COG1484	DNA-dependent DNA replication
FOC12_RS19255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FOC12_RS19260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FOC12_RS19280	COG1363	Peptidase, m42
FOC12_RS19285	COG1309	transcriptional regulator
FOC12_RS19290	COG1566	PFAM secretion protein HlyD family protein
FOC12_RS19295	COG2814	Major facilitator Superfamily
FOC12_RS19320	COG1418	mRNA catabolic process
FOC12_RS19330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOC12_RS19340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC12_RS19340	COG0072	phenylalanine-tRNA ligase activity
FOC12_RS19345	COG0017	Asparaginyl-tRNA synthetase
FOC12_RS19375	COG1286	toxin biosynthetic process
FOC12_RS19380	COG1796	DNA polymerase
FOC12_RS19380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FOC12_RS19390	COG1187	pseudouridine synthase activity
FOC12_RS19395	COG1114	Component of the transport system for branched-chain amino acids
FOC12_RS19400	COG5386	Cell surface protein
FOC12_RS19410	COG5386	Cell surface protein
FOC12_RS19425	COG1120	ATPase activity
FOC12_RS19430	COG4509	Sortase family
FOC12_RS19445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FOC12_RS19450	COG4895	conserved protein (DUF2196)
FOC12_RS19455	COG0745	RESPONSE REGULATOR receiver
FOC12_RS19460	COG2205	protein histidine kinase activity
FOC12_RS19465	COG1131	(ABC) transporter
FOC12_RS19490	COG2318	DinB family
FOC12_RS19510	COG0318	PFAM AMP-dependent synthetase and ligase
FOC12_RS19515	COG1309	transcriptional regulator
FOC12_RS19520	COG1024	Enoyl-CoA hydratase
FOC12_RS19525	COG2086	electron transfer activity
FOC12_RS19530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FOC12_RS19535	COG3118	belongs to the thioredoxin family
FOC12_RS19545	COG1719	4-vinyl reductase, 4VR
FOC12_RS19550	COG2009	succinate dehydrogenase
FOC12_RS19555	COG1053	succinate dehydrogenase
FOC12_RS19560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FOC12_RS19565	COG0824	Thioesterase
FOC12_RS19570	COG1876	peptidase activity
FOC12_RS19575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FOC12_RS19585	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FOC12_RS19590	COG4152	abc transporter atp-binding protein
FOC12_RS19595	COG1668	transmembrane transport
FOC12_RS19600	COG1959	2 iron, 2 sulfur cluster binding
FOC12_RS19610	COG0697	spore germination
FOC12_RS19615	COG1396	sequence-specific DNA binding
FOC12_RS19620	COG1983	PspC domain protein
FOC12_RS19635	COG3279	Response regulator of the LytR AlgR family
FOC12_RS19645	COG4608	Belongs to the ABC transporter superfamily
FOC12_RS19650	COG0444	Belongs to the ABC transporter superfamily
FOC12_RS19670	COG0402	S-adenosylhomocysteine deaminase activity
FOC12_RS19675	COG0402	S-adenosylhomocysteine deaminase activity
FOC12_RS19685	COG2233	PERMEase
FOC12_RS19690	COG2197	response regulator
FOC12_RS19705	COG1309	transcriptional regulator
FOC12_RS19725	COG5401	PFAM Sporulation and spore germination
FOC12_RS19735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FOC12_RS19740	COG0622	Phosphoesterase
FOC12_RS19785	COG0470	DNA polymerase III
FOC12_RS19785	COG1067	ATP-dependent peptidase activity
FOC12_RS19800	COG1764	response to oxidative stress
FOC12_RS19805	COG1846	Transcriptional regulator
FOC12_RS19815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FOC12_RS19825	COG1587	Uroporphyrinogen-III synthase
FOC12_RS19830	COG0113	porphobilinogen synthase activity
FOC12_RS19840	COG1388	LysM domain
FOC12_RS19850	COG0525	valine-tRNA ligase activity
FOC12_RS19855	COG0285	dihydrofolate synthase activity
FOC12_RS19875	COG1077	Cell shape determining protein MreB Mrl
FOC12_RS19880	COG1792	Involved in formation and maintenance of cell shape
FOC12_RS19895	COG2894	cell division
FOC12_RS19900	COG0739	heme binding
FOC12_RS19905	COG1994	Peptidase M50
FOC12_RS19910	COG1530	ribonuclease E activity
FOC12_RS19920	COG2868	ribosomal protein
FOC12_RS19935	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FOC12_RS19940	COG0745	RESPONSE REGULATOR receiver
FOC12_RS19950	COG1136	(ABC) transporter
FOC12_RS19955	COG0577	efflux transmembrane transporter activity
FOC12_RS19960	COG0577	efflux transmembrane transporter activity
FOC12_RS19965	COG0077	Prephenate dehydratase
FOC12_RS19970	COG2258	MOSC domain
FOC12_RS19975	COG1827	regulation of RNA biosynthetic process
FOC12_RS19980	COG1104	cysteine desulfurase activity
FOC12_RS19985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FOC12_RS19990	COG0157	Belongs to the NadC ModD family
FOC12_RS20015	COG0640	Transcriptional regulator
FOC12_RS20020	COG0697	spore germination
FOC12_RS20025	COG0697	spore germination
FOC12_RS20035	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FOC12_RS20065	COG1862	Preprotein translocase
FOC12_RS20075	COG2323	membrane
FOC12_RS20080	COG2244	polysaccharide biosynthetic process
FOC12_RS20090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOC12_RS20090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOC12_RS20095	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FOC12_RS20100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FOC12_RS20100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FOC12_RS20110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FOC12_RS20120	COG0124	histidyl-tRNA synthetase
FOC12_RS20130	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FOC12_RS20140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FOC12_RS20145	COG1959	2 iron, 2 sulfur cluster binding
FOC12_RS20150	COG1104	cysteine desulfurase activity
FOC12_RS20155	COG0482	sulfurtransferase activity
FOC12_RS20165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FOC12_RS20185	COG0628	permease
FOC12_RS20195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FOC12_RS20215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FOC12_RS20245	COG0768	penicillin binding
FOC12_RS20270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOC12_RS20275	COG0626	cystathionine gamma-synthase activity
FOC12_RS20280	COG1012	belongs to the aldehyde dehydrogenase family
FOC12_RS20280	COG1454	alcohol dehydrogenase
FOC12_RS20290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC12_RS20330	COG2259	Doxx family
FOC12_RS20345	COG3186	Phenylalanine-4-hydroxylase
FOC12_RS20385	COG2267	carboxylic ester hydrolase activity
FOC12_RS20395	COG1785	Belongs to the alkaline phosphatase family
FOC12_RS20405	COG2357	RelA SpoT domain protein
FOC12_RS20410	COG0778	Nitroreductase
FOC12_RS20420	COG1595	DNA-templated transcription, initiation
FOC12_RS20430	COG1191	sigma factor activity
FOC12_RS20445	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FOC12_RS20450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FOC12_RS20460	COG1534	Rna-binding protein
FOC12_RS20470	COG1713	HD superfamily hydrolase involved in NAD metabolism
FOC12_RS20475	COG0799	negative regulation of ribosome biogenesis
FOC12_RS20480	COG2226	methyltransferase
FOC12_RS20485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOC12_RS20490	COG1596	polysaccharide export
FOC12_RS20490	COG1555	photosystem II stabilization
FOC12_RS20495	COG2131	deaminase
FOC12_RS20500	COG2333	competence protein COMEC
FOC12_RS20500	COG0658	competence protein
FOC12_RS20510	COG1466	dna polymerase III delta subunit
FOC12_RS20535	COG1733	regulation of RNA biosynthetic process
FOC12_RS20540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FOC12_RS20550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FOC12_RS20570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FOC12_RS20575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC12_RS20585	COG1610	YqeY-like protein
FOC12_RS20600	COG1702	phosphate starvation-inducible protein PhoH
FOC12_RS20605	COG1480	7TM receptor with intracellular HD hydrolase
FOC12_RS20615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FOC12_RS20620	COG0295	cytidine deaminase activity
FOC12_RS20625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FOC12_RS20640	COG0517	IMP dehydrogenase activity
FOC12_RS20650	COG0358	DNA primase activity
FOC12_RS20655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOC12_RS20660	COG2010	Cytochrome c
FOC12_RS20665	COG2384	SAM-dependent methyltransferase
FOC12_RS20670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FOC12_RS20700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC12_RS20705	COG1121	(ABC) transporter
FOC12_RS20710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOC12_RS20715	COG0735	belongs to the Fur family
FOC12_RS20740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FOC12_RS20745	COG0477	Major facilitator Superfamily
FOC12_RS20755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FOC12_RS20760	COG0573	inorganic phosphate transmembrane transporter activity
FOC12_RS20765	COG0581	inorganic phosphate transmembrane transporter activity
FOC12_RS20770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FOC12_RS20775	COG0704	Plays a role in the regulation of phosphate uptake
FOC12_RS20780	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FOC12_RS20790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FOC12_RS20795	COG4483	Protein conserved in bacteria
FOC12_RS20800	COG1940	carbohydrate kinase activity
FOC12_RS20810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC12_RS20830	COG0626	cystathionine gamma-synthase activity
FOC12_RS20835	COG0626	cystathionine gamma-synthase activity
FOC12_RS20840	COG0646	methionine synthase
FOC12_RS20840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FOC12_RS20845	COG1410	methionine synthase
FOC12_RS20845	COG0646	methionine synthase
FOC12_RS20850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOC12_RS20900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FOC12_RS20905	COG1459	type II secretion system
FOC12_RS20915	COG4970	Tfp pilus assembly protein FimT
FOC12_RS20970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOC12_RS21000	COG1725	Transcriptional regulator
FOC12_RS21005	COG1131	(ABC) transporter
FOC12_RS21040	COG2076	Multidrug Resistance protein
FOC12_RS21045	COG2076	Multidrug Resistance protein
FOC12_RS21055	COG1609	Transcriptional regulator
FOC12_RS21060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOC12_RS21065	COG0095	Lipoate-protein ligase
FOC12_RS21085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FOC12_RS21095	COG3872	metal-dependent enzyme
FOC12_RS21110	COG0006	proline dipeptidase activity
FOC12_RS21135	COG3854	ATPases associated with a variety of cellular activities
FOC12_RS21180	COG0511	ligase activity, forming carbon-carbon bonds
FOC12_RS21185	COG0439	Biotin carboxylase
FOC12_RS21190	COG1302	Protein conserved in bacteria
FOC12_RS21215	COG0142	geranyltranstransferase activity
FOC12_RS21225	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FOC12_RS21235	COG0497	DNA recombination
FOC12_RS21240	COG0750	zinc metalloprotease
FOC12_RS21245	COG0745	RESPONSE REGULATOR receiver
FOC12_RS21255	COG3093	addiction module antidote protein HigA
FOC12_RS21260	COG0584	glycerophosphoryl diester phosphodiesterase
FOC12_RS21270	COG3829	transcription factor binding
FOC12_RS21270	COG3290	protein histidine kinase activity
FOC12_RS21275	COG0280	phosphate acetyltransferase
FOC12_RS21280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FOC12_RS21290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOC12_RS21295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOC12_RS21300	COG0022	dehydrogenase e1 component
FOC12_RS21305	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC12_RS21310	COG0772	Belongs to the SEDS family
FOC12_RS21330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOC12_RS21335	COG0765	amino acid transport
FOC12_RS21340	COG1126	abc transporter atp-binding protein
FOC12_RS21345	COG4129	membrane
FOC12_RS21350	COG1376	ErfK ybiS ycfS ynhG family protein
FOC12_RS21365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC12_RS21370	COG2195	Cleaves the N-terminal amino acid of tripeptides
FOC12_RS21380	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FOC12_RS21400	COG1760	l-serine dehydratase
FOC12_RS21405	COG1760	l-serine dehydratase
FOC12_RS21410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOC12_RS21420	COG0300	oxidoreductase activity
FOC12_RS21435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FOC12_RS21445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOC12_RS21465	COG1522	sequence-specific DNA binding
FOC12_RS21475	COG0737	Belongs to the 5'-nucleotidase family
FOC12_RS21490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FOC12_RS21500	COG0156	8-amino-7-oxononanoate synthase activity
FOC12_RS21505	COG1073	alpha beta
FOC12_RS21505	COG2226	methyltransferase
FOC12_RS21510	COG4106	trans-aconitate 2-methyltransferase activity
FOC12_RS21515	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FOC12_RS21535	COG0307	riboflavin synthase, alpha
FOC12_RS21540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC12_RS21540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC12_RS21555	COG1073	alpha beta
FOC12_RS21560	COG0456	acetyltransferase
FOC12_RS21565	COG1609	Transcriptional regulator
FOC12_RS21570	COG2056	Na+-H+ antiporter family
FOC12_RS21575	COG0596	Alpha beta hydrolase
FOC12_RS21585	COG4085	toxin activity
FOC12_RS21585	COG0737	Belongs to the 5'-nucleotidase family
FOC12_RS21585	COG1525	nuclease
FOC12_RS21595	COG0456	acetyltransferase
FOC12_RS21595	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FOC12_RS21600	COG0656	L-ascorbic acid biosynthetic process
FOC12_RS21605	COG0667	Aldo Keto reductase
FOC12_RS21625	COG1300	Membrane
FOC12_RS21630	COG0735	belongs to the Fur family
FOC12_RS21640	COG4974	Belongs to the 'phage' integrase family
FOC12_RS21665	COG0598	Magnesium transport protein CorA
FOC12_RS21680	COG1846	Transcriptional regulator
FOC12_RS21695	COG1131	(ABC) transporter
FOC12_RS21700	COG1725	Transcriptional regulator
FOC12_RS21705	COG1686	Belongs to the peptidase S11 family
FOC12_RS21725	COG0733	neurotransmitter:sodium symporter activity
FOC12_RS21750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC12_RS21765	COG0697	spore germination
FOC12_RS21770	COG0561	phosphatase activity
FOC12_RS21775	COG4086	secreted protein
FOC12_RS21780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FOC12_RS21785	COG0456	acetyltransferase
FOC12_RS21790	COG1547	Domain of unknown function (DUF309)
FOC12_RS21815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FOC12_RS21835	COG3711	transcriptional antiterminator
FOC12_RS21840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC12_RS21840	COG1263	PTS System
FOC12_RS21840	COG2190	(PTS) system
FOC12_RS21865	COG0778	Nitroreductase
FOC12_RS21870	COG3706	GGDEF domain
FOC12_RS21890	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FOC12_RS21910	COG0436	Aminotransferase
FOC12_RS21915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FOC12_RS21935	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS21940	COG1695	Transcriptional regulator
FOC12_RS21980	COG0183	Belongs to the thiolase family
FOC12_RS22020	COG3842	ATPase activity
FOC12_RS22025	COG0366	Alpha amylase catalytic
FOC12_RS22035	COG2182	Extracellular solute-binding protein
FOC12_RS22040	COG1175	transmembrane transport
FOC12_RS22045	COG3833	ABC-type maltose transport systems, permease component
FOC12_RS22050	COG1609	Transcriptional regulator
FOC12_RS22055	COG0436	Aminotransferase
FOC12_RS22065	COG2205	protein histidine kinase activity
FOC12_RS22075	COG3209	COG3209 Rhs family protein
FOC12_RS22095	COG2814	Major facilitator Superfamily
FOC12_RS22130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FOC12_RS22140	COG1408	metallophosphoesterase
FOC12_RS22145	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS22150	COG2200	EAL domain
FOC12_RS22165	COG4703	Protein of unknown function (DUF1797)
FOC12_RS22170	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
FOC12_RS22180	COG0517	IMP dehydrogenase activity
FOC12_RS22185	COG0583	DNA-binding transcription factor activity
FOC12_RS22205	COG0569	domain protein
FOC12_RS22210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FOC12_RS22225	COG0242	peptide deformylase activity
FOC12_RS22235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOC12_RS22240	COG0022	dehydrogenase e1 component
FOC12_RS22245	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC12_RS22290	COG1982	Orn Lys Arg decarboxylase major
FOC12_RS22310	COG0483	inositol monophosphate 1-phosphatase activity
FOC12_RS22335	COG4896	Protein conserved in bacteria
FOC12_RS22345	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FOC12_RS22350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FOC12_RS22355	COG4838	Belongs to the UPF0358 family
FOC12_RS22360	COG0772	Belongs to the SEDS family
FOC12_RS22365	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FOC12_RS22400	COG3336	cytochrome c oxidase
FOC12_RS22415	COG2340	Cysteine-rich secretory protein family
FOC12_RS22430	COG0406	alpha-ribazole phosphatase activity
FOC12_RS22435	COG3679	Belongs to the UPF0342 family
FOC12_RS22450	COG0742	ribosomal rna small subunit methyltransferase
FOC12_RS22460	COG3314	Sporulation integral membrane protein YlbJ
FOC12_RS22465	COG1752	Esterase of the alpha-beta hydrolase superfamily
FOC12_RS22470	COG3480	Lon protease (S16) C-terminal proteolytic domain
FOC12_RS22480	COG0582	viral genome integration into host DNA
FOC12_RS22490	COG1396	sequence-specific DNA binding
FOC12_RS22500	COG1396	sequence-specific DNA binding
FOC12_RS22520	COG1484	DNA-dependent DNA replication
FOC12_RS22545	COG1191	sigma factor activity
FOC12_RS22620	COG0582	viral genome integration into host DNA
FOC12_RS22645	COG4626	Terminase
FOC12_RS22645	COG1802	Transcriptional regulator
FOC12_RS22735	COG4824	toxin secretion phage lysis holin
FOC12_RS22785	COG1399	metal-binding, possibly nucleic acid-binding protein
FOC12_RS22810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FOC12_RS22825	COG4839	cell division protein FtsL
FOC12_RS22835	COG0768	penicillin binding
FOC12_RS22840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FOC12_RS22855	COG0772	Belongs to the SEDS family
FOC12_RS22860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOC12_RS22865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FOC12_RS22870	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FOC12_RS22875	COG0849	cell division
FOC12_RS22880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FOC12_RS22890	COG1191	sigma factor activity
FOC12_RS22895	COG1191	sigma factor activity
FOC12_RS22900	COG1873	PFAM PRC-barrel domain
FOC12_RS22910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FOC12_RS22920	COG0762	integral membrane protein
FOC12_RS22925	COG2302	S4 RNA-binding domain
FOC12_RS22930	COG3599	regulation of cell shape
FOC12_RS22950	COG0564	pseudouridine synthase activity
FOC12_RS22975	COG0505	Belongs to the CarA family
FOC12_RS23015	COG3069	C4-dicarboxylate transmembrane transporter activity
FOC12_RS23030	COG0006	proline dipeptidase activity
FOC12_RS23040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOC12_RS23045	COG1561	YicC-like family, N-terminal region
FOC12_RS23055	COG0194	GDP metabolic process
FOC12_RS23065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FOC12_RS23070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FOC12_RS23075	COG0242	peptide deformylase activity
FOC12_RS23085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOC12_RS23085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FOC12_RS23095	COG0631	protein serine/threonine phosphatase activity
FOC12_RS23100	COG2815	serine threonine protein kinase
FOC12_RS23100	COG0515	serine threonine protein kinase
FOC12_RS23105	COG1162	GTPase activity
FOC12_RS23110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FOC12_RS23115	COG1564	THIamine pyrophosphokinase
FOC12_RS23130	COG1302	Protein conserved in bacteria
FOC12_RS23135	COG1461	Dihydroxyacetone kinase
FOC12_RS23140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FOC12_RS23155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FOC12_RS23160	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS23175	COG1196	nuclear chromosome segregation
FOC12_RS23180	COG0552	protein localization to endoplasmic reticulum
FOC12_RS23190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FOC12_RS23200	COG1837	Belongs to the UPF0109 family
FOC12_RS23240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FOC12_RS23250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FOC12_RS23260	COG4974	Belongs to the 'phage' integrase family
FOC12_RS23290	COG0528	UMP kinase activity
FOC12_RS23300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FOC12_RS23305	COG4589	Belongs to the CDS family
FOC12_RS23310	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FOC12_RS23315	COG0750	zinc metalloprotease
FOC12_RS23335	COG0195	Participates in both transcription termination and antitermination
FOC12_RS23340	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FOC12_RS23345	COG1358	cellular component organization or biogenesis
FOC12_RS23355	COG1550	Protein conserved in bacteria
FOC12_RS23365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FOC12_RS23370	COG0196	riboflavin kinase activity
FOC12_RS23385	COG0726	polysaccharide deacetylase
FOC12_RS23390	COG0612	Peptidase, M16
FOC12_RS23395	COG1873	PFAM PRC-barrel domain
FOC12_RS23400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOC12_RS23405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FOC12_RS23410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FOC12_RS23415	COG0527	aspartate kinase activity
FOC12_RS23425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FOC12_RS23430	COG0740	serine-type endopeptidase activity
FOC12_RS23440	COG1674	ftsk spoiiie
FOC12_RS23445	COG2188	Transcriptional regulator
FOC12_RS23470	COG0612	Peptidase, M16
FOC12_RS23475	COG0612	Peptidase, M16
FOC12_RS23480	COG0300	oxidoreductase activity
FOC12_RS23495	COG1426	Protein conserved in bacteria
FOC12_RS23500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FOC12_RS23525	COG1692	metallophosphoesterase
FOC12_RS23530	COG2359	stage V sporulation protein S
FOC12_RS23540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FOC12_RS23540	COG0674	pyruvate-flavodoxin oxidoreductase activity
FOC12_RS23545	COG1013	pyruvate-flavodoxin oxidoreductase activity
FOC12_RS23550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC12_RS23555	COG4550	Control of competence regulator ComK, YlbF/YmcA
FOC12_RS23600	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FOC12_RS23610	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FOC12_RS23615	COG1368	sulfuric ester hydrolase activity
FOC12_RS23620	COG0562	UDP-galactopyranose mutase
FOC12_RS23625	COG3773	Cell wall hydrolase
FOC12_RS23630	COG1404	Belongs to the peptidase S8 family
FOC12_RS23650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FOC12_RS23655	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC12_RS23655	COG0596	Alpha beta hydrolase
FOC12_RS23660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOC12_RS23665	COG1380	Effector of murein hydrolase LrgA
FOC12_RS23670	COG1346	cytolysis
FOC12_RS23690	COG5001	Diguanylate cyclase
FOC12_RS23690	COG3300	MHYT domain
FOC12_RS23695	COG0346	lactoylglutathione lyase activity
FOC12_RS23700	COG2267	carboxylic ester hydrolase activity
FOC12_RS23715	COG2364	Membrane
FOC12_RS23725	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FOC12_RS23730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FOC12_RS23735	COG2169	Transcriptional regulator
FOC12_RS23740	COG0708	Exodeoxyribonuclease III
FOC12_RS23750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC12_RS23755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC12_RS23760	COG1120	ATPase activity
FOC12_RS23765	COG2819	hydrolase of the alpha beta superfamily
FOC12_RS23775	COG1937	Protein conserved in bacteria
FOC12_RS23780	COG2608	mercury ion transmembrane transporter activity
FOC12_RS23785	COG2217	Heavy metal translocating P-type atpase
FOC12_RS23795	COG2116	formate transmembrane transporter activity
FOC12_RS23800	COG1408	metallophosphoesterase
FOC12_RS23810	COG1113	amino acid transport
FOC12_RS23820	COG2322	membrane
FOC12_RS23830	COG1349	DNA-binding transcription factor activity
FOC12_RS23835	COG1105	Belongs to the carbohydrate kinase PfkB family
FOC12_RS23840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOC12_RS23840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FOC12_RS23840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FOC12_RS23845	COG1388	LysM domain
FOC12_RS23845	COG3584	3D domain protein
FOC12_RS23875	COG0464	growth
FOC12_RS23885	COG2860	membrane
FOC12_RS23895	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FOC12_RS23900	COG0789	Transcriptional regulator
FOC12_RS23905	COG0174	glutamine synthetase
FOC12_RS23925	COG1396	sequence-specific DNA binding
FOC12_RS24005	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FOC12_RS24040	COG1595	DNA-templated transcription, initiation
FOC12_RS24185	COG4824	toxin secretion phage lysis holin
FOC12_RS24190	COG3409	Peptidoglycan-binding domain 1 protein
FOC12_RS24190	COG1388	LysM domain
FOC12_RS24190	COG5632	N-Acetylmuramoyl-L-alanine amidase
FOC12_RS24220	COG1695	Transcriptional regulator
FOC12_RS24240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FOC12_RS24260	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FOC12_RS24265	COG3639	organic phosphonate transmembrane transporter activity
FOC12_RS24295	COG1132	(ABC) transporter
FOC12_RS24300	COG1132	(ABC) transporter
FOC12_RS24315	COG5632	N-Acetylmuramoyl-L-alanine amidase
FOC12_RS24315	COG3409	Peptidoglycan-binding domain 1 protein
FOC12_RS24340	COG1346	cytolysis
FOC12_RS24345	COG1380	Effector of murein hydrolase LrgA
FOC12_RS24350	COG0583	DNA-binding transcription factor activity
FOC12_RS24360	COG0785	Cytochrome C biogenesis protein
FOC12_RS24365	COG4846	Membrane protein involved in cytochrome C biogenesis
FOC12_RS24415	COG2226	methyltransferase
FOC12_RS24440	COG0010	Belongs to the arginase family
FOC12_RS24445	COG1329	Transcriptional regulator
FOC12_RS24450	COG1902	pentaerythritol trinitrate reductase activity
FOC12_RS24455	COG0069	glutamate synthase activity
FOC12_RS24460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC12_RS24465	COG0346	lactoylglutathione lyase activity
FOC12_RS24470	COG0400	carboxylic ester hydrolase activity
FOC12_RS24475	COG5002	protein histidine kinase activity
FOC12_RS24485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC12_RS24535	COG0318	PFAM AMP-dependent synthetase and ligase
FOC12_RS24540	COG1268	BioY protein
FOC12_RS24545	COG0318	PFAM AMP-dependent synthetase and ligase
FOC12_RS24550	COG0183	Belongs to the thiolase family
FOC12_RS24565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FOC12_RS24595	COG0726	polysaccharide deacetylase
FOC12_RS24605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FOC12_RS24610	COG2274	protein secretion by the type I secretion system
FOC12_RS24620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC12_RS24650	COG0824	Thioesterase
FOC12_RS24655	COG4841	protein insertion into membrane
FOC12_RS24660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FOC12_RS24675	COG0745	RESPONSE REGULATOR receiver
FOC12_RS24680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC12_RS24685	COG1832	CoA-binding protein
FOC12_RS24690	COG0187	DNA topoisomerase II activity
FOC12_RS24695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOC12_RS24700	COG0673	inositol 2-dehydrogenase activity
FOC12_RS24710	COG1131	(ABC) transporter
FOC12_RS24725	COG1595	DNA-templated transcription, initiation
FOC12_RS24735	COG1316	TRANSCRIPTIONal
FOC12_RS24745	COG4166	transmembrane transport
FOC12_RS24750	COG4166	transmembrane transport
FOC12_RS24755	COG4166	transmembrane transport
FOC12_RS24760	COG2226	methyltransferase
FOC12_RS24800	COG0697	spore germination
FOC12_RS24805	COG3383	formate dehydrogenase (NAD+) activity
FOC12_RS24810	COG2427	Protein of unknown function (DUF1641)
FOC12_RS24815	COG5609	conserved protein (DUF2294)
FOC12_RS24820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FOC12_RS24830	COG2116	formate transmembrane transporter activity
FOC12_RS24835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOC12_RS24840	COG0303	'Molybdopterin
FOC12_RS24845	COG0314	molybdopterin synthase activity
FOC12_RS24855	COG0489	protein tyrosine kinase activity
FOC12_RS24870	COG3326	Membrane
FOC12_RS24875	COG2962	Rard protein
FOC12_RS24880	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
FOC12_RS24885	COG1657	PFAM Prenyltransferase squalene oxidase
FOC12_RS24895	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS24900	COG1012	belongs to the aldehyde dehydrogenase family
FOC12_RS24905	COG3924	membrane
FOC12_RS24910	COG4145	pantothenate transmembrane transporter activity
FOC12_RS24925	COG0165	Argininosuccinate lyase
FOC12_RS24935	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS24965	COG0716	FMN binding
FOC12_RS24975	COG1278	Cold shock
FOC12_RS25000	COG2720	vancomycin resistance protein
FOC12_RS25005	COG2514	catechol 2,3-dioxygenase activity
FOC12_RS25020	COG1285	pathogenesis
FOC12_RS25030	COG1024	Enoyl-CoA hydratase
FOC12_RS25035	COG1216	Glycosyl transferase, family 2
FOC12_RS25065	COG0277	FAD linked oxidase domain protein
FOC12_RS25070	COG0385	Bile acid
FOC12_RS25080	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FOC12_RS25085	COG2808	Putative FMN-binding domain
FOC12_RS25105	COG0604	alcohol dehydrogenase
FOC12_RS25110	COG0640	Transcriptional regulator
FOC12_RS25135	COG0584	glycerophosphoryl diester phosphodiesterase
FOC12_RS25165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FOC12_RS25170	COG1164	Oligoendopeptidase f
FOC12_RS25190	COG1193	negative regulation of DNA recombination
FOC12_RS25210	COG0583	DNA-binding transcription factor activity
FOC12_RS25240	COG0384	phenazine biosynthesis protein PhzF
FOC12_RS25245	COG3739	integral membrane protein
FOC12_RS25250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC12_RS25255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC12_RS25260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC12_RS25280	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FOC12_RS25285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FOC12_RS25315	COG2814	Major facilitator Superfamily
FOC12_RS25320	COG1113	amino acid transport
FOC12_RS25360	COG2072	flavoprotein involved in K transport
FOC12_RS25395	COG3757	hydrolase, family 25
FOC12_RS25395	COG3409	Peptidoglycan-binding domain 1 protein
FOC12_RS25400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC12_RS25410	COG1151	hydroxylamine reductase activity
FOC12_RS25435	COG3152	Membrane
FOC12_RS25455	COG1309	transcriptional regulator
FOC12_RS25470	COG1191	sigma factor activity
FOC12_RS25505	COG1733	regulation of RNA biosynthetic process
FOC12_RS25515	COG0318	PFAM AMP-dependent synthetase and ligase
FOC12_RS25525	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS25535	COG0384	phenazine biosynthesis protein PhzF
FOC12_RS25555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC12_RS25570	COG1733	regulation of RNA biosynthetic process
FOC12_RS25575	COG1733	regulation of RNA biosynthetic process
FOC12_RS25580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FOC12_RS25590	COG2188	Transcriptional regulator
FOC12_RS25595	COG1733	regulation of RNA biosynthetic process
FOC12_RS25600	COG1393	Belongs to the ArsC family
FOC12_RS25625	COG0814	amino acid
FOC12_RS25630	COG0346	lactoylglutathione lyase activity
FOC12_RS25645	COG2814	Major facilitator Superfamily
FOC12_RS25650	COG0656	L-ascorbic acid biosynthetic process
FOC12_RS25675	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS25690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOC12_RS25695	COG0604	alcohol dehydrogenase
FOC12_RS25700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FOC12_RS25705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FOC12_RS25715	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FOC12_RS25720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FOC12_RS25730	COG1070	Carbohydrate kinase
FOC12_RS25735	COG2706	6-phosphogluconolactonase activity
FOC12_RS25740	COG3813	Protein conserved in bacteria
FOC12_RS25745	COG1357	PFAM Pentapeptide repeats (8 copies)
FOC12_RS25750	COG0697	spore germination
FOC12_RS25755	COG0789	Transcriptional regulator
FOC12_RS25760	COG1253	flavin adenine dinucleotide binding
FOC12_RS25790	COG0477	Major facilitator Superfamily
FOC12_RS25800	COG2226	methyltransferase
FOC12_RS25815	COG0628	permease
FOC12_RS25820	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FOC12_RS25825	COG0180	Tryptophanyl-tRNA synthetase
FOC12_RS25830	COG1136	(ABC) transporter
FOC12_RS25840	COG0110	maltose O-acetyltransferase activity
FOC12_RS25845	COG0738	Major facilitator superfamily
FOC12_RS25850	COG1940	carbohydrate kinase activity
FOC12_RS25855	COG0346	lactoylglutathione lyase activity
FOC12_RS25890	COG1011	Hydrolase
FOC12_RS25915	COG1131	(ABC) transporter
FOC12_RS25925	COG1028	Short-chain dehydrogenase reductase Sdr
FOC12_RS25945	COG0778	Nitroreductase
FOC12_RS25950	COG1733	regulation of RNA biosynthetic process
FOC12_RS25965	COG0124	histidyl-tRNA synthetase
FOC12_RS25970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FOC12_RS25975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FOC12_RS25980	COG3620	sequence-specific DNA binding
FOC12_RS25995	COG2356	endonuclease I
FOC12_RS26000	COG1288	antiporter activity
FOC12_RS26005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FOC12_RS26020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FOC12_RS26025	COG1122	ATPase activity
FOC12_RS26055	COG2249	NAD(P)H dehydrogenase (quinone) activity
FOC12_RS26065	COG2031	fatty acid transporter
FOC12_RS26075	COG1309	transcriptional regulator
FOC12_RS26080	COG2076	Multidrug Resistance protein
FOC12_RS26100	COG1131	(ABC) transporter
FOC12_RS26105	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FOC12_RS26120	COG2814	Major facilitator Superfamily
FOC12_RS26125	COG1846	Transcriptional regulator
FOC12_RS26135	COG0477	Major facilitator Superfamily
FOC12_RS26185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC12_RS26185	COG2207	Transcriptional regulator
FOC12_RS26190	COG0662	Cupin 2, conserved barrel domain protein
FOC12_RS26205	COG1595	DNA-templated transcription, initiation
FOC12_RS26225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FOC12_RS26240	COG0531	amino acid
FOC12_RS26245	COG1522	sequence-specific DNA binding
FOC12_RS26250	COG1335	isochorismatase
FOC12_RS26260	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FOC12_RS26265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FOC12_RS26275	COG1760	l-serine dehydratase
FOC12_RS26280	COG1760	l-serine dehydratase
FOC12_RS26285	COG0814	amino acid
FOC12_RS26300	COG1309	transcriptional regulator
FOC12_RS26305	COG2814	Major facilitator Superfamily
FOC12_RS26325	COG0534	Mate efflux family protein
FOC12_RS26355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FOC12_RS26370	COG0457	Tetratricopeptide repeat
FOC12_RS26375	COG1609	Transcriptional regulator
FOC12_RS26385	COG0561	phosphatase activity
FOC12_RS26390	COG0673	inositol 2-dehydrogenase activity
FOC12_RS26395	COG0738	Major facilitator superfamily
FOC12_RS26415	COG1619	proteins homologs of microcin C7 resistance protein MccF
FOC12_RS26425	COG0583	DNA-binding transcription factor activity
FOC12_RS26435	COG1139	Iron-sulfur cluster binding protein
FOC12_RS26440	COG1556	Lactate utilization protein
FOC12_RS26445	COG2271	Major facilitator Superfamily
FOC12_RS26450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC12_RS26455	COG2808	Putative FMN-binding domain
FOC12_RS26465	COG1846	Transcriptional regulator
FOC12_RS26470	COG2364	Membrane
FOC12_RS26480	COG5002	protein histidine kinase activity
FOC12_RS26480	COG3850	Histidine kinase
FOC12_RS26495	COG0577	efflux transmembrane transporter activity
FOC12_RS26500	COG1136	(ABC) transporter
FOC12_RS26515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FOC12_RS26520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC12_RS26530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC12_RS26535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC12_RS26550	COG1476	TRANSCRIPTIONal
FOC12_RS26570	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FOC12_RS26595	COG3850	Histidine kinase
FOC12_RS26595	COG5002	protein histidine kinase activity
FOC12_RS26600	COG0745	RESPONSE REGULATOR receiver
FOC12_RS26625	COG2814	Major facilitator Superfamily
FOC12_RS26665	COG2169	Transcriptional regulator
FOC12_RS26690	COG0346	lactoylglutathione lyase activity
FOC12_RS26705	COG1522	sequence-specific DNA binding
FOC12_RS26720	COG0443	Heat shock 70 kDa protein
FOC12_RS26735	COG0640	Transcriptional regulator
FOC12_RS26740	COG0346	lactoylglutathione lyase activity
FOC12_RS26745	COG0798	PFAM Bile acid sodium symporter
FOC12_RS26775	COG1121	(ABC) transporter
FOC12_RS26780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOC12_RS26785	COG0803	Belongs to the bacterial solute-binding protein 9 family
FOC12_RS26790	COG2267	carboxylic ester hydrolase activity
FOC12_RS26795	COG1575	Belongs to the MenA family. Type 1 subfamily
FOC12_RS26810	COG5609	conserved protein (DUF2294)
FOC12_RS26815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC12_RS26825	COG0288	reversible hydration of carbon dioxide
FOC12_RS26830	COG0415	Belongs to the DNA photolyase family
FOC12_RS26870	COG1846	Transcriptional regulator
FOC12_RS26875	COG0583	DNA-binding transcription factor activity
FOC12_RS26895	COG1335	isochorismatase
FOC12_RS26900	COG2267	carboxylic ester hydrolase activity
FOC12_RS26905	COG0753	catalase activity
FOC12_RS26910	COG0737	Belongs to the 5'-nucleotidase family
FOC12_RS26945	COG2066	Belongs to the glutaminase family
FOC12_RS26955	COG0784	Response regulator, receiver
FOC12_RS26980	COG0281	malic enzyme
FOC12_RS26990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOC12_RS26995	COG1114	Component of the transport system for branched-chain amino acids
FOC12_RS27000	COG0531	amino acid
FOC12_RS27005	COG0322	excinuclease ABC activity
FOC12_RS27015	COG1396	sequence-specific DNA binding
FOC12_RS27020	COG0252	asparaginase activity
FOC12_RS27025	COG1027	Aspartate ammonia-lyase
FOC12_RS27040	COG1063	alcohol dehydrogenase
FOC12_RS27070	COG1280	lysine exporter protein (LysE YggA)