locus-tag class description FOC13_RS00010 ENOG41068WN FOC13_RS00045 ENOG4105F6J Alpha beta hydrolase fold FOC13_RS00065 ENOG4105CYC Transferase FOC13_RS00070 ENOG4105DY9 regulatoR FOC13_RS00080 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC13_RS00085 ENOG4105C6X Major Facilitator FOC13_RS00110 ENOG4105C7B Threonine dehydratase FOC13_RS00120 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC13_RS00125 ENOG4108ZP8 Acetolactate synthase small subunit FOC13_RS00130 ENOG4105C7K acetolactate synthase FOC13_RS00135 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC13_RS00140 ENOG4105CHR reductase FOC13_RS00145 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC13_RS00160 ENOG4106KE4 Dehydrogenase FOC13_RS00175 ENOG4105H67 Protein of unknown function (DUF421) FOC13_RS00180 ENOG4105X5K response regulator receiver protein FOC13_RS00190 ENOG4105C8J )-transporter FOC13_RS00210 ENOG4105C6T cysteine synthase FOC13_RS00215 ENOG4105EU0 Major facilitator Superfamily FOC13_RS00245 ENOG4105CSR polyphosphate kinase 2 FOC13_RS00285 ENOG4105FVX FOC13_RS00345 ENOG4105C6K Malic enzyme FOC13_RS00350 ENOG4108IJ0 Aspartate ammonia-lyase FOC13_RS00360 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC13_RS00380 ENOG4105CJ1 ABC, transporter FOC13_RS00415 ENOG4106BRA Membrane FOC13_RS00445 ENOG4107QIV Cytochrome c biogenesis protein FOC13_RS00465 ENOG4105EC3 peptidase S51, dipeptidase E FOC13_RS00490 ENOG4105C9Q fumarate hydratase class II FOC13_RS00495 ENOG4105DFD Na H antiporter FOC13_RS00510 ENOG4108PJD permease FOC13_RS00515 ENOG4105CKI cobalamin synthesis protein FOC13_RS00520 ENOG4108UZ3 Transporter FOC13_RS00525 ENOG4105DRR Transcriptional regulator, GntR family FOC13_RS00535 ENOG4105PGM cation diffusion facilitator family transporter FOC13_RS00555 ENOG4105CAQ asparagine synthetase FOC13_RS00585 ENOG4105CVJ phosphoglycerate mutase FOC13_RS00625 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC13_RS00630 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC13_RS00635 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC13_RS00640 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC13_RS00645 ENOG4105DUM transcriptional regulator, lysR family FOC13_RS00670 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC13_RS00690 ENOG4108RZE Tetr family transcriptional regulator FOC13_RS00715 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC13_RS00720 ENOG4105KTQ flagellar basal-body rod protein FOC13_RS00730 ENOG4105D7B Flagellar biosynthesis protein flha FOC13_RS00735 ENOG4105D00 flagellar biosynthetic protein flhB FOC13_RS00745 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC13_RS00750 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC13_RS00760 ENOG4105DD5 Flagellar motor switch protein FOC13_RS00775 ENOG4105E4C Lytic transglycosylase catalytic FOC13_RS00780 ENOG4105I03 Flagellin FOC13_RS00815 ENOG4105K64 Glycosyl transferase, family 2 FOC13_RS00840 ENOG4105BZE flagellar hook protein, FlgE FOC13_RS00875 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC13_RS00885 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOC13_RS00890 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC13_RS00895 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC13_RS00920 ENOG4105E1Q flagellar hook-associated protein FOC13_RS00940 ENOG4105BZU Histidine kinase FOC13_RS00955 ENOG4105DD5 Flagellar motor switch protein FOC13_RS00965 ENOG4107YTP response regulator receiver protein FOC13_RS00970 ENOG4105ER2 Ompa motb domain protein FOC13_RS00975 ENOG4107R0U MotA TolQ exbB proton channel FOC13_RS00985 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC13_RS01040 ENOG41080C8 DUF218 domain FOC13_RS01045 ENOG4105H67 Protein of unknown function (DUF421) FOC13_RS01055 ENOG4108Z5V transcriptional regulator, merr family FOC13_RS01065 ENOG4107RWR Sodium hydrogen exchanger FOC13_RS01075 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC13_RS01140 ENOG41081VK Ribonuclease FOC13_RS01160 ENOG4108SZE gCN5-related N-acetyltransferase FOC13_RS01260 ENOG4105KHC sulfurtransferase FOC13_RS01270 ENOG4108W0I acetyltransferase FOC13_RS01280 ENOG410890F Dynamin family FOC13_RS01285 ENOG4105DHF Membrane FOC13_RS01290 ENOG4105C2W permease FOC13_RS01305 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC13_RS01320 ENOG4105CTD carboxy-peptidase FOC13_RS01325 ENOG4105DVT helicase FOC13_RS01335 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC13_RS01390 ENOG4105BZ4 penicillin-binding protein FOC13_RS01400 ENOG4105CSM endonuclease III FOC13_RS01420 ENOG4105YAC FOC13_RS01425 ENOG4105DVT helicase FOC13_RS01460 ENOG4105CPK Glycosyl transferase (Group 1 FOC13_RS01465 ENOG4105FJR Lmbe family FOC13_RS01480 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC13_RS01485 ENOG4108JYZ YitT family FOC13_RS01515 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC13_RS01520 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC13_RS01525 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC13_RS01540 ENOG41068YB TPR repeat-containing protein FOC13_RS01545 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC13_RS01565 ENOG4105EAH synthase FOC13_RS01575 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC13_RS01590 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC13_RS01620 ENOG41065D1 FOC13_RS01625 ENOG4105S2F FOC13_RS01660 ENOG4105HDK L-asparaginase FOC13_RS01665 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC13_RS01690 ENOG4108S6Z Negative regulator of genetic competence FOC13_RS01695 ENOG4107X2D transcriptional regulator, merr family FOC13_RS01710 ENOG4105I7S Abortive infection protein FOC13_RS01715 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC13_RS01720 ENOG4105T7X FOC13_RS01730 ENOG4108SAX Membrane FOC13_RS01745 ENOG4108WBT adenosyltransferase FOC13_RS01750 ENOG4105BZU Histidine kinase FOC13_RS01755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_RS01760 ENOG4105CRE cytochrome C FOC13_RS01765 ENOG4107TWT Cytochrome c biogenesis protein FOC13_RS01775 ENOG4105FE9 pseudouridine synthase FOC13_RS01785 ENOG4108JIC nucleoside recognition domain protein FOC13_RS01790 ENOG4105DZ1 carboxypeptidase FOC13_RS01795 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC13_RS01830 ENOG4105BZU Histidine kinase FOC13_RS01845 ENOG4105I3N Conserved Protein FOC13_RS01865 ENOG4105BZ4 penicillin-binding protein FOC13_RS01870 ENOG4107GRR phosphate transport regulator FOC13_RS01875 ENOG4105CJ3 phosphate transporter FOC13_RS01895 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC13_RS01920 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC13_RS01940 ENOG4105WH1 Two component transcriptional regulator luxr family FOC13_RS01945 ENOG4105ENE Histidine kinase FOC13_RS01965 ENOG4105DFD Na H antiporter FOC13_RS01985 ENOG4105C8J )-transporter FOC13_RS01990 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC13_RS01995 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC13_RS02000 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC13_RS02010 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC13_RS02015 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC13_RS02035 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC13_RS02045 ENOG4105E0M Sulfatase FOC13_RS02050 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC13_RS02065 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC13_RS02100 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC13_RS02125 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC13_RS02135 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC13_RS02140 ENOG4108ZP8 Acetolactate synthase small subunit FOC13_RS02145 ENOG4105C7K acetolactate synthase FOC13_RS02150 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC13_RS02175 ENOG4105KBJ sporulation protein ytfj FOC13_RS02180 ENOG41063Y9 FOC13_RS02185 ENOG4105CZN Potassium uptake protein FOC13_RS02215 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC13_RS02220 ENOG4107QMU Mate efflux family protein FOC13_RS02245 ENOG4105NQC Flavodoxin FOC13_RS02265 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC13_RS02275 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC13_RS02280 ENOG4105EA8 2-Nitropropane dioxygenase FOC13_RS02285 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC13_RS02325 ENOG4105CJ1 ABC, transporter FOC13_RS02335 ENOG4105CZV ABC transporter FOC13_RS02340 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC13_RS02345 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC13_RS02365 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC13_RS02400 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC13_RS02405 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC13_RS02415 ENOG4105BZU Histidine kinase FOC13_RS02420 ENOG4106DF1 FOC13_RS02430 ENOG41090MY MarR family Transcriptional regulator FOC13_RS02435 ENOG4105BZU Histidine kinase FOC13_RS02445 ENOG4105PXI polysaccharide deacetylase FOC13_RS02465 ENOG4105E98 transcriptional regulator DeoR family FOC13_RS02480 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC13_RS02495 ENOG4105C4Y ABC transporter FOC13_RS02510 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC13_RS02520 ENOG4105CHR reductase FOC13_RS02540 ENOG4108Z7G MaoC domain protein dehydratase FOC13_RS02545 ENOG410681C small acid-soluble spore protein FOC13_RS02550 ENOG4105CZN Potassium uptake protein FOC13_RS02555 ENOG4107TS3 membrane protein, TerC FOC13_RS02560 ENOG4108QTI )-transporter FOC13_RS02570 ENOG4106A3R peptidase FOC13_RS02590 ENOG4105JXH GntR family transcriptional regulator FOC13_RS02595 ENOG4105BZU Histidine kinase FOC13_RS02600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_RS02615 ENOG4105CQB FAD linked oxidase domain protein FOC13_RS02620 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC13_RS02625 ENOG4105K4I Scp-like extracellular FOC13_RS02635 ENOG4108YBP pseudouridine synthase FOC13_RS02645 ENOG4105EYF MMPL domain protein FOC13_RS02655 ENOG4107RUE extracellular solute-binding protein family 1 FOC13_RS02660 ENOG4105D38 putrescine abc transporter FOC13_RS02665 ENOG4105F38 ABC transporter, permease FOC13_RS02670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC13_RS02675 ENOG4105C26 Dehydrogenase FOC13_RS02710 ENOG4105VFR signal peptidase FOC13_RS02715 ENOG4105DZ1 carboxypeptidase FOC13_RS02725 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC13_RS02785 ENOG4105VZ8 Transcriptional regulator FOC13_RS02795 ENOG4105C7S Dehydrogenase FOC13_RS02890 ENOG4105DDQ anthranilate synthase FOC13_RS02900 ENOG4105CK7 Sodium proline symporter FOC13_RS02925 ENOG4108WVJ 2'-5' rna ligase FOC13_RS02975 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC13_RS02985 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC13_RS02990 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC13_RS03010 ENOG4107TVC Glycosyl transferase, family 2 FOC13_RS03030 ENOG4105K64 Glycosyl transferase, family 2 FOC13_RS03050 ENOG4105EMS pseudouridine synthase FOC13_RS03055 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC13_RS03070 ENOG4105MIX Adenylate cyclase FOC13_RS03075 ENOG4108Z18 K06886 hemoglobin FOC13_RS03085 ENOG4105DPN Oligoendopeptidase f FOC13_RS03095 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC13_RS03105 ENOG4108ZCF integral membrane protein FOC13_RS03125 ENOG4105UQX Mate efflux family protein FOC13_RS03130 ENOG4108JQ7 (ABC) transporter FOC13_RS03140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC13_RS03145 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC13_RS03160 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC13_RS03175 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC13_RS03180 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC13_RS03205 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC13_RS03215 ENOG4108KP7 hydrolase FOC13_RS03225 ENOG41073B9 FOC13_RS03230 ENOG4107AYK membrAne FOC13_RS03240 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC13_RS03250 ENOG4105QNR S1 RNA binding domain protein FOC13_RS03275 ENOG4105CH6 catalase FOC13_RS03280 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC13_RS03285 ENOG4105CAQ asparagine synthetase FOC13_RS03310 ENOG4105ERH Fumarylacetoacetate hydrolase FOC13_RS03355 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC13_RS03360 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC13_RS03375 ENOG4105XVF Competence transcription factor FOC13_RS03390 ENOG4105VEQ Cold shock protein FOC13_RS03405 ENOG4107QP3 malate synthase g FOC13_RS03410 ENOG4105ZU5 s-layer protein FOC13_RS03430 ENOG4105C8Q Methyl-accepting chemotaxis FOC13_RS03435 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC13_RS03460 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_RS03475 ENOG41086D8 Transcriptional regulator FOC13_RS03480 ENOG4108AEY RNA polymerase sigma factor FOC13_RS03490 ENOG4107TVP HD domain protein FOC13_RS03525 ENOG4105CNA YD repeat protein FOC13_RS03555 ENOG4105CEY Amp-dependent synthetase and ligase FOC13_RS03565 ENOG4105DF9 Lipoate-protein, ligase FOC13_RS03570 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC13_RS03575 ENOG4106AXD FOC13_RS03605 ENOG4105ECB domain protein FOC13_RS03620 ENOG4105NA0 Transcriptional regulator FOC13_RS03645 ENOG4105C1Q protoporphyrinogen oxidase FOC13_RS03655 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC13_RS03660 ENOG4105BZ4 penicillin-binding protein FOC13_RS03665 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC13_RS03670 ENOG4105CKV Membrane FOC13_RS03675 ENOG410905X membrane-flanked domain protein FOC13_RS03720 ENOG410905X membrane-flanked domain protein FOC13_RS03750 ENOG4105K59 histidine triad (HIT) protein FOC13_RS03775 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC13_RS03780 ENOG4105EEM helicase FOC13_RS03790 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC13_RS03795 ENOG4105C57 major facilitator superfamily FOC13_RS03820 ENOG4105EMN RNA polymerase sigma factor FOC13_RS03830 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC13_RS03845 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC13_RS03865 ENOG4108MUZ hydrolase FOC13_RS03885 ENOG4105EQ0 Major Facilitator superfamily FOC13_RS03890 ENOG4108IND Tetr family transcriptional regulator FOC13_RS03905 ENOG4105D7V transposase FOC13_RS03915 ENOG4107VRP DNA repair exonuclease FOC13_RS03945 ENOG4105K8R UPF0145 protein FOC13_RS03965 ENOG4105BZU Histidine kinase FOC13_RS03970 ENOG4105BZU Histidine kinase FOC13_RS03975 ENOG4108MJI response regulator FOC13_RS03985 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_RS03995 ENOG4105WN5 stage II sporulation protein FOC13_RS04060 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC13_RS04090 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC13_RS04095 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC13_RS04100 ENOG4105CMT Dihydroxyacetone kinase FOC13_RS04110 ENOG4105CMT Dihydroxyacetone kinase FOC13_RS04130 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC13_RS04150 ENOG4108IG5 Transcriptional regulator FOC13_RS04155 ENOG4107P5I polyketide synthase FOC13_RS04200 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC13_RS04230 ENOG4105CDU Replicative dna helicase FOC13_RS04280 ENOG4108MRH transcriptional regulatory protein FOC13_RS04290 ENOG4105CSH Transporter FOC13_RS04320 ENOG4105PKS Excinuclease abc c subunit domain protein FOC13_RS04325 ENOG4108JQ7 (ABC) transporter FOC13_RS04335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC13_RS04375 ENOG4105CTU Proline racemase FOC13_RS04395 ENOG4105DER m42 family FOC13_RS04415 ENOG4105CGU Enoyl-CoA hydratase FOC13_RS04430 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC13_RS04435 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC13_RS04445 ENOG4106AKK s-layer domain-containing protein FOC13_RS04485 ENOG4105CHH sulfate transporter FOC13_RS04500 ENOG4105D4P Coproporphyrinogen iii oxidase FOC13_RS04530 ENOG4107FQX Alpha-acetolactate decarboxylase FOC13_RS04565 ENOG410839P FOC13_RS04580 ENOG4105CDA abc transporter atp-binding protein FOC13_RS04585 ENOG4105DRP amino acid AbC transporter FOC13_RS04600 ENOG4105BZ1 (ABC) transporter FOC13_RS04605 ENOG4105C26 Dehydrogenase FOC13_RS04615 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC13_RS04620 ENOG4105D5Q Arginine ornithine antiporter FOC13_RS04630 ENOG4105CH6 catalase FOC13_RS04635 ENOG4107RKG DJ-1/PfpI family FOC13_RS04645 ENOG4105E5W Transporter FOC13_RS04650 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC13_RS04655 ENOG4105NF4 modulator of drug activity FOC13_RS04680 ENOG4105KPY Small multidrug resistance protein FOC13_RS04685 ENOG4105KPY Small multidrug resistance protein FOC13_RS04695 ENOG4108YXU transcriptional regulator AsnC family FOC13_RS04700 ENOG4108PCN EamA-like transporter family FOC13_RS04735 ENOG4106KNT transcriptional regulator FOC13_RS04745 ENOG4107RWR Sodium hydrogen exchanger FOC13_RS04750 ENOG4105CUB amino acid FOC13_RS04780 ENOG4107T5V SNARE associated Golgi FOC13_RS04815 ENOG4105WEF catalase FOC13_RS04845 ENOG4105C19 ABC transporter FOC13_RS04850 ENOG4107RBB ABC transporter, permease FOC13_RS04855 ENOG41069ER domain protein FOC13_RS04875 ENOG4105VZJ PTS System FOC13_RS04880 ENOG4105VCP PTS System FOC13_RS04885 ENOG4105EMD TRANSCRIPTIONal FOC13_RS04910 ENOG4108KGH TRANSCRIPTIONal FOC13_RS04920 ENOG41087NI Sulfite exporter TauE/SafE FOC13_RS04925 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC13_RS04935 ENOG41085GJ domain protein FOC13_RS04940 ENOG4105VFE sira family FOC13_RS04945 ENOG4107TPS domain protein FOC13_RS04950 ENOG4105VFE sira family FOC13_RS04955 ENOG4105XTG Pfam:DUF156 FOC13_RS04960 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC13_RS04985 ENOG4105ED1 spovr family FOC13_RS04990 ENOG4107Y03 Nitroreductase FOC13_RS05045 ENOG4105C5Y PTS System FOC13_RS05075 ENOG4105C7N Xanthine uracil vitamin C permease FOC13_RS05090 ENOG4108INS Transcriptional regulator FOC13_RS05140 ENOG4105DWF phosphomethylpyrimidine kinase FOC13_RS05145 ENOG4105D06 uba thif-type nad fad binding protein FOC13_RS05160 ENOG41080HI glycine oxidase FOC13_RS05165 ENOG4108VEU Thiamine monophosphate synthase FOC13_RS05175 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC13_RS05185 ENOG4105ETU transcriptional activator (TenA FOC13_RS05205 ENOG41080XQ Signal transduction protein with cbs domains FOC13_RS05330 ENOG4105E2Z phosphate ABC transporter (Permease FOC13_RS05335 ENOG4105C8U phosphate abc transporter FOC13_RS05340 ENOG4105CVA phosphate FOC13_RS05345 ENOG4105CE1 Ferrous iron transport protein b FOC13_RS05350 ENOG4105CE1 Ferrous iron transport protein b FOC13_RS05355 ENOG4105CE1 Ferrous iron transport protein b FOC13_RS05360 ENOG4108NHD germination protein FOC13_RS05375 ENOG4105E1V na solute symporter FOC13_RS05380 ENOG4106CAD Protein of unknown function (DUF3311) FOC13_RS05395 ENOG4108IQI permease FOC13_RS05400 ENOG4105E2S oxidase) subunit II FOC13_RS05405 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC13_RS05445 ENOG4105C7N Xanthine uracil vitamin C permease FOC13_RS05450 ENOG4105C85 amino acid FOC13_RS05470 ENOG4105DUX Transporter FOC13_RS05480 ENOG4107D63 FOC13_RS05485 ENOG4105VZ8 Transcriptional regulator FOC13_RS05490 ENOG41069ER domain protein FOC13_RS05495 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC13_RS05500 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC13_RS05560 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC13_RS05565 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC13_RS05570 ENOG4105CNN ABC, transporter FOC13_RS05585 ENOG4108RVA ribokinase FOC13_RS05590 ENOG4105ETE Transcriptional regulator (LacI family FOC13_RS05600 ENOG41067TZ transcriptional regulator, MarR family FOC13_RS05605 ENOG4105CXY transporter FOC13_RS05615 ENOG4108JQ7 (ABC) transporter FOC13_RS05620 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC13_RS05630 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC13_RS05640 ENOG41068KF Universal stress protein FOC13_RS05645 ENOG4105CHH sulfate transporter FOC13_RS05660 ENOG4105BZU Histidine kinase FOC13_RS05665 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC13_RS05670 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC13_RS05695 ENOG4108IQI permease FOC13_RS05700 ENOG4105DRP amino acid AbC transporter FOC13_RS05705 ENOG4105EAD ABC transporter FOC13_RS05710 ENOG4105CT1 (ABC) transporter FOC13_RS05715 ENOG4105CDA abc transporter atp-binding protein FOC13_RS05720 ENOG4105BZG amino acid carrier protein FOC13_RS05725 ENOG4105CRN Aminoglycoside phosphotransferase FOC13_RS05735 ENOG4105E1K spore germination protein FOC13_RS05750 ENOG4105CG3 alpha amylase, catalytic region FOC13_RS05755 ENOG4105C5Y PTS System FOC13_RS05760 ENOG4107414 GntR family transcriptional regulator FOC13_RS05765 ENOG4105D5Q Arginine ornithine antiporter FOC13_RS05770 ENOG4105BZU Histidine kinase FOC13_RS05785 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC13_RS05790 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC13_RS05795 ENOG4107T89 von Willebrand factor, type A FOC13_RS05805 ENOG4105EXW epimerase dehydratase FOC13_RS05815 ENOG4105DMQ Methyltransferase FOC13_RS05820 ENOG4105E0A ABC, transporter FOC13_RS05825 ENOG4108IHU transport system permease protein FOC13_RS05830 ENOG4105DQ5 transport system permease protein FOC13_RS05835 ENOG4108MES Periplasmic binding protein FOC13_RS05840 ENOG4105DUX Transporter FOC13_RS05855 ENOG4105DAA L-lactate FOC13_RS05860 ENOG4108IJ0 Aspartate ammonia-lyase FOC13_RS05865 ENOG4105C37 (CBS) domain FOC13_RS05870 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC13_RS05875 ENOG4105D9N nucleoside FOC13_RS05880 ENOG4108KGH TRANSCRIPTIONal FOC13_RS05885 ENOG41073R8 VanW family FOC13_RS05920 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC13_RS05925 ENOG4105C59 p-type ATPase FOC13_RS05935 ENOG4105CUB amino acid FOC13_RS05955 ENOG4108JB9 formate dehydrogenase FOC13_RS05960 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC13_RS05965 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC13_RS05970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_RS05975 ENOG4105BZU Histidine kinase FOC13_RS05985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC13_RS05990 ENOG4108UZ3 Transporter FOC13_RS06000 ENOG4105C6K Malic enzyme FOC13_RS06010 ENOG4108MRH transcriptional regulatory protein FOC13_RS06035 ENOG4105US7 Histidine kinase FOC13_RS06040 ENOG4108STX response regulator FOC13_RS06045 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC13_RS06050 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC13_RS06055 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC13_RS06060 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC13_RS06065 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC13_RS06070 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC13_RS06090 ENOG4105D4T Citrate transporter FOC13_RS06100 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC13_RS06110 ENOG4105DZ6 Band 7 protein FOC13_RS06125 ENOG4105C94 Transporter FOC13_RS06130 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC13_RS06145 ENOG4105CYN Serine protein kinase FOC13_RS06150 ENOG4105BZU Histidine kinase FOC13_RS06155 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC13_RS06165 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC13_RS06175 ENOG4107ZQN disulfide bond FOC13_RS06180 ENOG4108JQC penicillin-binding protein 1A FOC13_RS06295 ENOG4105G5W regulator Fur family FOC13_RS06300 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC13_RS06320 ENOG4108IUW ABC transporter FOC13_RS06330 ENOG4105CBC glutamate synthase FOC13_RS06335 ENOG4107NBY Membrane FOC13_RS06340 ENOG4105BZ1 (ABC) transporter FOC13_RS06360 ENOG4106BXE FOC13_RS06365 ENOG4105CEN a g-specific adenine glycosylase FOC13_RS06370 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC13_RS06400 ENOG4105ECP epimerase FOC13_RS06405 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC13_RS06425 ENOG4105F1A Pyruvate formate-lyase FOC13_RS06445 ENOG4105C3I Nad-dependent epimerase dehydratase FOC13_RS06450 ENOG4107QQG Dehydrogenase FOC13_RS06460 ENOG4105CKK Glycosyl transferase, family 2 FOC13_RS06475 ENOG4108A04 Beta-lactamase FOC13_RS06485 ENOG4105CSV Glutaminase FOC13_RS06510 ENOG4108IQI permease FOC13_RS06520 ENOG4108JUB Transcriptional regulator FOC13_RS06530 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC13_RS06785 ENOG4108IMY Transcriptional regulator FOC13_RS06790 ENOG4105VTR Integrase FOC13_RS06795 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC13_RS06835 ENOG4105UPD Calcium Proton FOC13_RS06840 ENOG410606W general stress protein FOC13_RS06855 ENOG4107ZTW SNARE associated Golgi FOC13_RS06875 ENOG4108IPJ Membrane FOC13_RS06880 ENOG4105C59 p-type ATPase FOC13_RS06885 ENOG4107U9T Pfam:Ribonuclease_BN FOC13_RS06895 ENOG4105KJF protein tyrosine phosphatase FOC13_RS06915 ENOG4108TTB tellurium resistance protein FOC13_RS06920 ENOG4107TS3 membrane protein, TerC FOC13_RS06925 ENOG4106FN3 tellurium resistance protein FOC13_RS06930 ENOG4106FN3 tellurium resistance protein FOC13_RS06935 ENOG4108N0M stress protein FOC13_RS06950 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FOC13_RS06965 ENOG4105DEU major facilitator superfamily FOC13_RS06985 ENOG41062JF Transcriptional regulator FOC13_RS07010 ENOG4105C5H ABC transporter FOC13_RS07025 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC13_RS07040 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC13_RS07070 ENOG4105CI1 PTS System FOC13_RS07080 ENOG4105C8Q Methyl-accepting chemotaxis FOC13_RS07085 ENOG4105C8Q Methyl-accepting chemotaxis FOC13_RS07095 ENOG4105EAB amino acid AbC transporter FOC13_RS07100 ENOG4105E5Q amino acid AbC transporter FOC13_RS07115 ENOG4105D2S major facilitator superfamily FOC13_RS07120 ENOG410756H nucleotidyltransferase FOC13_RS07140 ENOG4105BZU Histidine kinase FOC13_RS07165 ENOG4106UIA FOC13_RS07170 ENOG4106UIA FOC13_RS07190 ENOG4108V5C ABC transporter FOC13_RS07195 ENOG4105DQ5 transport system permease protein FOC13_RS07200 ENOG4105EHG Permease protein FOC13_RS07205 ENOG4107W7X Aldolase FOC13_RS07215 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOC13_RS07220 ENOG4105D3R alkyl hydroperoxide reductase FOC13_RS07240 ENOG4105DFD Na H antiporter FOC13_RS07250 ENOG4105DTQ mandelate racemase muconate lactonizing FOC13_RS07265 ENOG4108W15 Protein of unknown function (DUF1456) FOC13_RS07280 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC13_RS07285 ENOG4105D9N nucleoside FOC13_RS07305 ENOG4105KPY Small multidrug resistance protein FOC13_RS07310 ENOG4105C26 Dehydrogenase FOC13_RS07320 ENOG4108JPW Aminotransferase FOC13_RS07325 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC13_RS07330 ENOG4105CBD Diacylglycerol kinase FOC13_RS07355 ENOG410834F Transcriptional regulator FOC13_RS07375 ENOG4105D01 (LipO)protein FOC13_RS07380 ENOG4108UMI ABC transporter, permease FOC13_RS07385 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC13_RS07390 ENOG4108W2Y isochorismatase FOC13_RS07415 ENOG4105C4R Atp-dependent dna helicase FOC13_RS07440 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC13_RS07450 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC13_RS07475 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC13_RS07485 ENOG4105C83 adenylosuccinate lyase FOC13_RS07490 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC13_RS07495 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC13_RS07515 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_RS07535 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC13_RS07575 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC13_RS07610 ENOG4105BZU Histidine kinase FOC13_RS07620 ENOG4105C7N Xanthine uracil vitamin C permease FOC13_RS07640 ENOG4108TYN CAAX amino terminal protease family protein FOC13_RS07655 ENOG4105C5H ABC transporter FOC13_RS07660 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC13_RS07665 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC13_RS07670 ENOG41072GX Peptidase M22 Glycoprotease FOC13_RS07675 ENOG4105K8N protein family UPF0079, ATPase FOC13_RS07775 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC13_RS07785 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC13_RS07790 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC13_RS07800 ENOG4107ZXI Rhomboid family FOC13_RS07815 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC13_RS07825 ENOG4108SC4 )-transporter FOC13_RS07835 ENOG4105ERH Fumarylacetoacetate hydrolase FOC13_RS07840 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC13_RS07860 ENOG4108JQ7 (ABC) transporter FOC13_RS07865 ENOG4105C3U ABC transporter FOC13_RS07870 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC13_RS07880 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC13_RS07895 ENOG4105C5H ABC transporter FOC13_RS07915 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC13_RS07920 ENOG4108RE7 deoxyribonuclease FOC13_RS07930 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC13_RS07950 ENOG4105F6E Acyl-transferase FOC13_RS07970 ENOG4105EGI Transcriptional regulator FOC13_RS07980 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC13_RS07990 ENOG4105E0C molybdate abc transporter FOC13_RS08000 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC13_RS08005 ENOG4105II7 pyrroline-5-carboxylate reductase FOC13_RS08015 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC13_RS08020 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC13_RS08050 ENOG4108JQ7 (ABC) transporter FOC13_RS08055 ENOG4105C3U ABC transporter FOC13_RS08060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC13_RS08065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC13_RS08080 ENOG4105C2C drug resistance transporter, Bcr CflA FOC13_RS08095 ENOG4105IQ5 FAD linked oxidase domain protein FOC13_RS08105 ENOG4105EE1 crotonyl-CoA reductase FOC13_RS08110 ENOG4105D01 (LipO)protein FOC13_RS08115 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC13_RS08120 ENOG4108UMI ABC transporter, permease FOC13_RS08155 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC13_RS08160 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC13_RS08180 ENOG4108VQT Alpha beta hydrolase fold protein FOC13_RS08185 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC13_RS08200 ENOG4107U5W ybbr family FOC13_RS08205 ENOG4105C8B TIGR00159 family FOC13_RS08285 ENOG4108NMV polysaccharide deacetylase FOC13_RS08300 ENOG4105D1F ATP-binding protein FOC13_RS08325 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC13_RS08330 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC13_RS08335 ENOG4108JJB ABC transporter FOC13_RS08365 ENOG41067V7 50S ribosomal protein L36 FOC13_RS08375 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC13_RS08385 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC13_RS08410 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC13_RS08515 ENOG4105XPM ribosomal protein FOC13_RS08520 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC13_RS08530 ENOG4107Y49 methyltransferase FOC13_RS08555 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC13_RS08570 ENOG4105QIV RNA polymerase FOC13_RS08575 ENOG4105M0M Tetracycline resistance protein FOC13_RS08580 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC13_RS08595 ENOG4105D7W serine acetyltransferase FOC13_RS08615 ENOG4105CTP PilT protein domain protein FOC13_RS08625 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC13_RS08640 ENOG4108Z0C Uvrb UvrC protein FOC13_RS08670 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC13_RS08680 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC13_RS08685 ENOG4105KRF dihydroneopterin aldolase FOC13_RS08690 ENOG4105EEI dihydropteroate synthase FOC13_RS08695 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC13_RS08700 ENOG4105DDQ anthranilate synthase FOC13_RS08705 ENOG4105CRQ synthase (Component I) FOC13_RS08710 ENOG4105C6T cysteine synthase FOC13_RS08725 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC13_RS08730 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC13_RS08735 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC13_RS08755 ENOG41060GV RNA binding s1 domain protein FOC13_RS08770 ENOG4105VYY sporulation protein yabp FOC13_RS08775 ENOG41082I2 s4 domain protein FOC13_RS08780 ENOG4108IY2 MazG family FOC13_RS08790 ENOG4108M14 stage v sporulation protein t FOC13_RS08795 ENOG4108JA2 transcriptioN-repair coupling factor FOC13_RS08805 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC13_RS08810 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC13_RS08825 ENOG4105KME endoribonuclease L-psp FOC13_RS08830 ENOG4105DFT pur operon repressor FOC13_RS08845 ENOG4105W42 Veg protein FOC13_RS08850 ENOG4105XFA sporulation peptidase YabG FOC13_RS08860 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC13_RS08865 ENOG4105F8V Hydrolase, tatD family FOC13_RS08875 ENOG4105KRN Transcriptional regulator, abrb family FOC13_RS08880 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC13_RS08890 ENOG41060K3 Methyltransferase FOC13_RS08900 ENOG4105MA4 psp1 domain protein FOC13_RS08905 ENOG4105FA2 dna polymerase iii FOC13_RS08915 ENOG4105CXN decarboxylase FOC13_RS08950 ENOG41067KS pro-sigma K processing FOC13_RS08970 ENOG4105C6E dna polymerase iii FOC13_RS08980 ENOG4108Z6B deaminase FOC13_RS08985 ENOG4105GTG Isochorismatase FOC13_RS08995 ENOG4105ZMH deoxynucleoside kinase FOC13_RS09030 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC13_RS09065 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC13_RS09080 ENOG410848D S4 domain protein YaaA FOC13_RS09085 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC13_RS09105 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC13_RS09115 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC13_RS09135 ENOG4107QJE Chromosome Partitioning Protein FOC13_RS09140 ENOG4105FA0 parb-like partition protein FOC13_RS09145 ENOG4108ZDA Sporulation protein YyaC FOC13_RS09150 ENOG4105D8X mechanosensitive ion channel FOC13_RS09155 ENOG4105VDK protein, conserved in bacteria FOC13_RS09160 ENOG4105C3G gtp-binding protein FOC13_RS09170 ENOG4108UUM single-stranded DNA-binding protein FOC13_RS09180 ENOG4108XMW Membrane FOC13_RS09185 ENOG4105BZR domain protein FOC13_RS09195 ENOG4105CDU Replicative dna helicase FOC13_RS09225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_RS09230 ENOG4105BZU Histidine kinase FOC13_RS09245 ENOG4105Q2H domain protein FOC13_RS09250 ENOG4105C0H protease FOC13_RS09270 ENOG4105DPN Oligoendopeptidase f FOC13_RS09285 ENOG4105C1J atp-dependent rna helicase FOC13_RS09295 ENOG4108UT2 hemolysin iii FOC13_RS09300 ENOG4105CMR udp-glucose 4-epimerase FOC13_RS09310 ENOG4105IW1 AmiS UreI transporter FOC13_RS09320 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC13_RS09335 ENOG4107RGD Major Facilitator superfamily FOC13_RS09340 ENOG4108HRK Histidine kinase FOC13_RS09345 ENOG4105DY9 regulatoR FOC13_RS09360 ENOG4106F5Q Membrane FOC13_RS09365 ENOG4105E0X reductase FOC13_RS09375 ENOG41067SE Tetr family transcriptional regulator FOC13_RS09380 ENOG4105CKK Glycosyl transferase, family 2 FOC13_RS09400 ENOG4105C5H ABC transporter FOC13_RS09405 ENOG4105JEU Glycosyl transferase, family 2 FOC13_RS09415 ENOG4108S4H thioesterase Superfamily protein FOC13_RS09425 ENOG4106YBV Methyl-accepting chemotaxis FOC13_RS09430 ENOG4105EN6 Membrane FOC13_RS09450 ENOG41079KZ Major Facilitator Superfamily FOC13_RS09455 ENOG4105DY9 regulatoR FOC13_RS09460 ENOG4105D22 carbon starvation protein FOC13_RS09465 ENOG4105VCD cytoplasmic protein FOC13_RS09470 ENOG4105BZU Histidine kinase FOC13_RS09475 ENOG4105DWF phosphomethylpyrimidine kinase FOC13_RS09485 ENOG4105WH1 Two component transcriptional regulator luxr family FOC13_RS09495 ENOG4108Y4K DNA-binding transcriptional activator FOC13_RS09520 ENOG4105D6E homoserine dehydrogenase FOC13_RS09535 ENOG41090WU lipolytic protein G-D-S-L family FOC13_RS09540 ENOG4105CJ1 ABC, transporter FOC13_RS09545 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC13_RS09555 ENOG4105VCH membrane FOC13_RS09560 ENOG410667J hydrolase FOC13_RS09590 ENOG4108VKI Cell wall hydrolase FOC13_RS09605 ENOG4108IJ2 phosphate acetyltransferase FOC13_RS09620 ENOG4108VCI transcription factor, rsfa family FOC13_RS09635 ENOG4105EHG Permease protein FOC13_RS09640 ENOG4105E0A ABC, transporter FOC13_RS09645 ENOG4108MES Periplasmic binding protein FOC13_RS09650 ENOG4105DCI Phosphohydrolase FOC13_RS09655 ENOG41069HH 4-oxalocrotonate tautomerase FOC13_RS09660 ENOG4108Z4T Peptidase M50 FOC13_RS09665 ENOG4108XFG YwhD family FOC13_RS09670 ENOG4105BZ4 penicillin-binding protein FOC13_RS09675 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC13_RS09680 ENOG4107SWG transcriptional regulator MERR family FOC13_RS09685 ENOG4105DXB Major Facilitator superfamily FOC13_RS09695 ENOG4105CYW agmatinase FOC13_RS09715 ENOG410684U Domain of unknown function (DUF1934) FOC13_RS09725 ENOG4105EMN RNA polymerase sigma factor FOC13_RS09745 ENOG4105IIU Aminopeptidase FOC13_RS09755 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC13_RS09760 ENOG4108M15 ABC transporter FOC13_RS09765 ENOG4105KCT ABC transporter FOC13_RS09770 ENOG4105BZU Histidine kinase FOC13_RS09800 ENOG4105BZU Histidine kinase FOC13_RS09815 ENOG4105DF6 Fe-S oxidoreductase FOC13_RS09825 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC13_RS09830 ENOG4105C1G acyl-Coa dehydrogenase FOC13_RS09835 ENOG4105C1G acyl-Coa dehydrogenase FOC13_RS09870 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC13_RS09875 ENOG4105CBT Fructose-1,6-bisphosphatase FOC13_RS09880 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC13_RS09895 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC13_RS09900 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC13_RS09905 ENOG4108ZXQ stage ii sporulation protein r FOC13_RS09915 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC13_RS09930 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC13_RS09935 ENOG4108VGI doxx family FOC13_RS09950 ENOG4108YZG isomerase FOC13_RS09980 ENOG41062M3 atp synthase FOC13_RS09985 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC13_RS10035 ENOG4105BZU Histidine kinase FOC13_RS10040 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC13_RS10050 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC13_RS10055 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC13_RS10080 ENOG4105D65 subunit l FOC13_RS10085 ENOG4105C8S subunit m FOC13_RS10090 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC13_RS10095 ENOG4106778 Protein of unknown function (DUF1146) FOC13_RS10115 ENOG4108IUW ABC transporter FOC13_RS10120 ENOG4105DY9 regulatoR FOC13_RS10135 ENOG4105FRN stage II sporulation protein FOC13_RS10150 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC13_RS10205 ENOG4105EY8 ABC transporter FOC13_RS10210 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC13_RS10225 ENOG4105CMR udp-glucose 4-epimerase FOC13_RS10230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_RS10235 ENOG4105BZU Histidine kinase FOC13_RS10250 ENOG4105CXY transporter FOC13_RS10270 ENOG4105C19 ABC transporter FOC13_RS10275 ENOG4107RBB ABC transporter, permease FOC13_RS10285 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_RS10315 ENOG4105C0D helicase FOC13_RS10320 ENOG4105KBK Zinc finger, swim domain protein FOC13_RS10345 ENOG41069ER domain protein FOC13_RS10350 ENOG4105C94 Transporter FOC13_RS10380 ENOG4105E0M Sulfatase FOC13_RS10390 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC13_RS10400 ENOG4105DAA L-lactate FOC13_RS10440 ENOG4107RSM transcriptional regulator FOC13_RS10445 ENOG4105ECB domain protein FOC13_RS10450 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_RS10465 ENOG4105VZJ PTS System FOC13_RS10475 ENOG4105VCP PTS System FOC13_RS10480 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC13_RS10485 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC13_RS10495 ENOG4105CK1 PTS System FOC13_RS10500 ENOG4105VCP PTS System FOC13_RS10505 ENOG4105F8D glycoside hydrolase family 4 FOC13_RS10510 ENOG410901P UPF0249 protein FOC13_RS10525 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC13_RS10535 ENOG4105ESV Glycosyl transferase, family 4 FOC13_RS10540 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC13_RS10545 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC13_RS10550 ENOG4108KGH TRANSCRIPTIONal FOC13_RS10555 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC13_RS10565 ENOG4105KVH Transcriptional regulator FOC13_RS10580 ENOG41081UC Inherit from COG: Competence protein FOC13_RS10585 ENOG4105VEQ Cold shock protein FOC13_RS10590 ENOG4105MS2 ribosomal subunit Interface protein FOC13_RS10595 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC13_RS10615 ENOG4105CAK Cell division ATP-binding protein ftsE FOC13_RS10620 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC13_RS10625 ENOG4105CN1 protease FOC13_RS10635 ENOG4105BZ1 (ABC) transporter FOC13_RS10650 ENOG4108WS4 fmn reductase FOC13_RS10660 ENOG4105DUM transcriptional regulator, lysR family FOC13_RS10665 ENOG4105HMI Membrane FOC13_RS10690 ENOG4107TXC Transcriptional regulator FOC13_RS10705 ENOG4105D7V transposase FOC13_RS10710 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC13_RS10715 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC13_RS10725 ENOG41086DT Membrane protein of unknown function FOC13_RS10745 ENOG4108S4C acetyltransferase FOC13_RS10755 ENOG4105C3M thioredoxin reductase FOC13_RS10765 ENOG4108Z4K mutator MutT protein FOC13_RS10775 ENOG4105CHW UPF0052 protein FOC13_RS10785 ENOG4105KRI phosphocarrier protein (HPr FOC13_RS10790 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC13_RS10795 ENOG4105H67 Protein of unknown function (DUF421) FOC13_RS10810 ENOG4105CZ3 stage V sporulation protein ad FOC13_RS10815 ENOG41090VF Stage v sporulation protein ac FOC13_RS10835 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_RS10860 ENOG4105CP7 Triose-phosphate isomerase FOC13_RS10865 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC13_RS10875 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC13_RS10900 ENOG4105EFC phage portal protein HK97 family FOC13_RS10995 ENOG41067MG lrgb family FOC13_RS11000 ENOG4105XZU Preprotein translocase, subunit SecG FOC13_RS11010 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC13_RS11040 ENOG4105CM4 permease protein FOC13_RS11045 ENOG4108IPW abc transporter atp-binding protein FOC13_RS11060 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOC13_RS11065 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC13_RS11080 ENOG4105WMR Protein CrcB homolog FOC13_RS11085 ENOG4105WMR Protein CrcB homolog FOC13_RS11095 ENOG4105C8Q Methyl-accepting chemotaxis FOC13_RS11105 ENOG4105D4A Cell wall formation (By similarity) FOC13_RS11110 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC13_RS11125 ENOG4105KVH Transcriptional regulator FOC13_RS11130 ENOG4105F27 Major Facilitator FOC13_RS11135 ENOG4105CV8 reductase FOC13_RS11150 ENOG4108RYK Nad-dependent epimerase dehydratase FOC13_RS11165 ENOG4105D9N nucleoside FOC13_RS11170 ENOG4105D9N nucleoside FOC13_RS11190 ENOG4108URH decarboxylase FOC13_RS11205 ENOG4108RMU ferritin dps family protein FOC13_RS11215 ENOG4105NCW Trka-c domain protein FOC13_RS11220 ENOG4107S91 Sodium hydrogen exchanger FOC13_RS11240 ENOG4105D4Y metalloprotease FOC13_RS11245 ENOG4105VG1 fes assembly suf system protein FOC13_RS11260 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC13_RS11270 ENOG4105BZU Histidine kinase FOC13_RS11275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_RS11280 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC13_RS11290 ENOG4107ZTW SNARE associated Golgi FOC13_RS11325 ENOG4107AYK membrAne FOC13_RS11335 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC13_RS11345 ENOG4107R7I amino acid FOC13_RS11350 ENOG4108SUT Major Facilitator Superfamily FOC13_RS11365 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC13_RS11385 ENOG4105DZ1 carboxypeptidase FOC13_RS11400 ENOG4105CHU acetyl-coa acetyltransferase FOC13_RS11405 ENOG4105C1G acyl-Coa dehydrogenase FOC13_RS11410 ENOG4108W8B Beta-lactamase domain protein FOC13_RS11435 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC13_RS11480 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC13_RS11515 ENOG4108UMI ABC transporter, permease FOC13_RS11520 ENOG4105D01 (LipO)protein FOC13_RS11525 ENOG4105D01 (LipO)protein FOC13_RS11530 ENOG4105C3K feS assembly ATPase SufC FOC13_RS11535 ENOG4105JRK feS assembly protein SufD FOC13_RS11540 ENOG4105C9B Cysteine desulfurase FOC13_RS11545 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC13_RS11550 ENOG4105DIW FeS assembly protein SUFB FOC13_RS11565 ENOG4107R8B 5'-nucleotidase FOC13_RS11570 ENOG4105KZD Domain of unknown function (DUF1805) FOC13_RS11580 ENOG4105FAA peptidase M23 FOC13_RS11605 ENOG41090T1 Membrane FOC13_RS11610 ENOG4107TXC Transcriptional regulator FOC13_RS11615 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC13_RS11620 ENOG4105MMD transcriptional regulator FOC13_RS11635 ENOG4105CBT Fructose-1,6-bisphosphatase FOC13_RS11650 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC13_RS11655 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC13_RS11665 ENOG4108W5N phosphatidylglycerophosphatase a FOC13_RS11680 ENOG41083MR nifu domain-containing protein FOC13_RS11725 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC13_RS11730 ENOG4105C4B ABC transporter, permease FOC13_RS11735 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC13_RS11760 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC13_RS11780 ENOG4105EWC Purine nucleoside phosphorylase FOC13_RS11810 ENOG4105CEP NADH dehydrogenase FOC13_RS11825 ENOG41069ER domain protein FOC13_RS11845 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC13_RS11865 ENOG4105KA0 thioesterase Superfamily protein FOC13_RS11870 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOC13_RS11885 ENOG4107R3E Citrate transporter FOC13_RS11895 ENOG4105Y38 Kinase-associated protein B FOC13_RS11905 ENOG4105C87 Aminotransferase class I and II FOC13_RS11915 ENOG4108MUZ hydrolase FOC13_RS11920 ENOG4105C5I Dehydrogenase FOC13_RS11925 ENOG4108ZB6 transcriptional regulator AsnC family FOC13_RS11930 ENOG4105CHM Aminotransferase FOC13_RS11940 ENOG4105WG9 Conserved Protein FOC13_RS11945 ENOG4107QYV phosphohexose isomerase FOC13_RS11955 ENOG4107PBV potassium channel FOC13_RS11960 ENOG4105KT7 mgtC SapB transporter FOC13_RS11995 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC13_RS12090 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC13_RS12110 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC13_RS12120 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC13_RS12140 ENOG4105VEQ Cold shock protein FOC13_RS12150 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC13_RS12155 ENOG4105E4F Isochorismate synthase FOC13_RS12160 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC13_RS12165 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC13_RS12170 ENOG4108IPT Naphthoate synthase FOC13_RS12180 ENOG4105DTQ mandelate racemase muconate lactonizing FOC13_RS12210 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC13_RS12230 ENOG4105FDP GntR family transcriptional regulator FOC13_RS12235 ENOG4105C6Z Gluconate FOC13_RS12275 ENOG41086D8 Transcriptional regulator FOC13_RS12280 ENOG4105C19 ABC transporter FOC13_RS12295 ENOG4107ZTW SNARE associated Golgi FOC13_RS12330 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC13_RS12335 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC13_RS12360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_RS12365 ENOG4105BZU Histidine kinase FOC13_RS12400 ENOG41087YS Phage shock protein A FOC13_RS12445 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC13_RS12450 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC13_RS12455 ENOG4108V2W Carbonate dehydratase FOC13_RS12510 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC13_RS12520 ENOG4105D2X ABC transporter substrate-binding protein FOC13_RS12540 ENOG4107S9D Alpha beta hydrolase FOC13_RS12545 ENOG4105BZU Histidine kinase FOC13_RS12550 ENOG4105BZU Histidine kinase FOC13_RS12555 ENOG4105EGD dinuclear metal center protein, YbgI family FOC13_RS12605 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC13_RS12615 ENOG4105BZF Glycosyl transferase (Group 1 FOC13_RS12620 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC13_RS12625 ENOG4108Z0R Transferase FOC13_RS12630 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC13_RS12660 ENOG4105DA5 (ABC) transporter FOC13_RS12670 ENOG4105N5T Radical SAM Protein FOC13_RS12690 ENOG4105C19 ABC transporter FOC13_RS12705 ENOG4105NCW Trka-c domain protein FOC13_RS12710 ENOG4107S91 Sodium hydrogen exchanger FOC13_RS12715 ENOG410605W Major Facilitator FOC13_RS12745 ENOG4108B31 Spore germination protein FOC13_RS12755 ENOG4105DWV Homoserine O-trans-acetylase FOC13_RS12765 ENOG41085GJ domain protein FOC13_RS12790 ENOG4105D06 uba thif-type nad fad binding protein FOC13_RS12800 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC13_RS12805 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC13_RS12810 ENOG4108ZAF Molybdopterin FOC13_RS12825 ENOG4105CSC Glucose uptake protein FOC13_RS12830 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC13_RS12835 ENOG4108VJ1 Transcriptional regulator (CarD family FOC13_RS12870 ENOG4105CBX hi0933 family FOC13_RS12885 ENOG4105YW5 deoR family transcriptional regulator FOC13_RS12900 ENOG4108IUM Glycogen debranching enzyme FOC13_RS12905 ENOG4108V15 phosphotransferase enzyme family FOC13_RS12920 ENOG4105C8F Beta-lactamase domain protein FOC13_RS12950 ENOG4108VDD TRNA binding domain protein FOC13_RS12995 ENOG4105C88 aminopeptidase FOC13_RS13015 ENOG4105ETE Transcriptional regulator (LacI family FOC13_RS13045 ENOG4105EP9 oxidoreductase FOC13_RS13050 ENOG4107SNB ankyrin repeat protein YahD FOC13_RS13060 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_RS13070 ENOG4105DGU Histone deacetylase FOC13_RS13075 ENOG4105W87 Cbs domain FOC13_RS13080 ENOG4105F1V Acetoin utilization protein FOC13_RS13100 ENOG4105EMN RNA polymerase sigma factor FOC13_RS13110 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC13_RS13130 ENOG4105C28 cystathionine FOC13_RS13150 ENOG4106KR7 LysR family Transcriptional regulator FOC13_RS13175 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC13_RS13185 ENOG4105EFZ amidohydrolase FOC13_RS13200 ENOG4105KBJ sporulation protein ytfj FOC13_RS13205 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC13_RS13215 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC13_RS13235 ENOG4108JYZ YitT family FOC13_RS13275 ENOG4107YZX Universal stress protein FOC13_RS13295 ENOG4105VZ8 Transcriptional regulator FOC13_RS13305 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC13_RS13310 ENOG4105Z7P Acetyltransferase (GNAT) family FOC13_RS13345 ENOG4105DC7 peptidase M24 FOC13_RS13380 ENOG4105SFS phosphoesterase RecJ domain protein FOC13_RS13390 ENOG4105VV2 FOC13_RS13395 ENOG4105C0B DNA polymerase III (alpha subunit) FOC13_RS13400 ENOG4105C6K Malic enzyme FOC13_RS13405 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC13_RS13430 ENOG4105FS0 cytoplasmic membrane protein FOC13_RS13435 ENOG4108REF Sporulation integral membrane protein ytvi FOC13_RS13445 ENOG4105BZN citrate synthase FOC13_RS13450 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC13_RS13465 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_RS13470 ENOG4105BZU Histidine kinase FOC13_RS13475 ENOG4105C2M dna polymerase I FOC13_RS13480 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC13_RS13490 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC13_RS13495 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC13_RS13505 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC13_RS13525 ENOG4108TDW sporulation protein YtxC FOC13_RS13530 ENOG4105C22 threonyL-tRNA synthetase FOC13_RS13535 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC13_RS13555 ENOG4105CN9 Peptidase m42 family protein FOC13_RS13560 ENOG4108JGH Tetr family transcriptional regulator FOC13_RS13565 ENOG4105CW7 secretion protein, HlyD family FOC13_RS13570 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC13_RS13605 ENOG4108RWN rrna methyltransferase FOC13_RS13615 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC13_RS13620 ENOG4105C5S asparaginyl-tRNA synthetase FOC13_RS13655 ENOG4105DCG PHP domain protein FOC13_RS13665 ENOG4105FE9 pseudouridine synthase FOC13_RS13675 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC13_RS13685 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC13_RS13700 ENOG4105E0A ABC, transporter FOC13_RS13705 ENOG4105KFN sortase, SrtB family FOC13_RS13720 ENOG4105DR4 Methyltransferase FOC13_RS13730 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_RS13770 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC13_RS13775 ENOG4105J76 Periplasmic binding protein FOC13_RS13785 ENOG4105CEY Amp-dependent synthetase and ligase FOC13_RS13790 ENOG4107Z3H Transcriptional regulator, TetR family FOC13_RS13795 ENOG41060WC Enoyl-CoA hydratase FOC13_RS13800 ENOG4105BZJ Electron transfer flavoprotein FOC13_RS13805 ENOG4105C10 Electron transfer flavoprotein FOC13_RS13810 ENOG4105K63 Thioredoxin FOC13_RS13825 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC13_RS13835 ENOG4105E33 succinate dehydrogenase FOC13_RS13845 ENOG4108VXD carboxy-peptidase FOC13_RS13850 ENOG4105E14 MotA TolQ exbB proton channel FOC13_RS13860 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC13_RS13865 ENOG4108IUX (ABC) transporter FOC13_RS13870 ENOG4105RHA ABC transporter, permease FOC13_RS13875 ENOG4108Z40 Transcriptional regulator FOC13_RS13880 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC13_RS13890 ENOG4108JCI Transcriptional regulator FOC13_RS13895 ENOG41067S9 phage shock protein C, PspC FOC13_RS13910 ENOG4105DY9 regulatoR FOC13_RS13920 ENOG4108JQ7 (ABC) transporter FOC13_RS13935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC13_RS13940 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC13_RS13945 ENOG4105DZC cytosine deaminase FOC13_RS13950 ENOG4105DZC cytosine deaminase FOC13_RS13965 ENOG4105PFC Transcriptional regulator FOC13_RS13980 ENOG4105KBX Transcriptional regulator, TetR family FOC13_RS13990 ENOG4108PCX Major Facilitator FOC13_RS14000 ENOG4108XJQ germination protein FOC13_RS14010 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC13_RS14015 ENOG4105M59 Phosphodiesterase, mj0936 family FOC13_RS14035 ENOG4108QCI YvbH-like oligomerisation region FOC13_RS14060 ENOG4108IUQ atp-dependent protease FOC13_RS14080 ENOG4105K56 Transcriptional regulator FOC13_RS14105 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC13_RS14115 ENOG41068KH stage VI sporulation protein D FOC13_RS14125 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC13_RS14130 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC13_RS14150 ENOG4105DFF Rod shape-determining protein mreb FOC13_RS14155 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC13_RS14170 ENOG4107QMS site-determining protein FOC13_RS14185 ENOG4105C03 ribonuclease FOC13_RS14195 ENOG4105X36 (ribosomal) protein FOC13_RS14210 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC13_RS14240 ENOG4105CQC Prephenate dehydratase FOC13_RS14245 ENOG4108RPX mosc domain containing protein FOC13_RS14260 ENOG4108IYU L-aspartate oxidase FOC13_RS14265 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC13_RS14290 ENOG41082BM Transcriptional regulator, arsr family FOC13_RS14295 ENOG4108IPJ Membrane FOC13_RS14300 ENOG4108IPJ Membrane FOC13_RS14310 ENOG4108HUF Transporter FOC13_RS14325 ENOG41061AI Protein of unknown function (DUF2905) FOC13_RS14340 ENOG4105VIE preprotein translocase, subunit YajC FOC13_RS14350 ENOG4108QG2 Membrane FOC13_RS14355 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC13_RS14365 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC13_RS14370 ENOG41076HS cation diffusion facilitator family transporter FOC13_RS14375 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC13_RS14385 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC13_RS14395 ENOG4105CUT histidyl-tRNA synthetase FOC13_RS14405 ENOG4105CUZ uba thif-type nad fad binding protein FOC13_RS14410 ENOG4108VCI transcription factor, rsfa family FOC13_RS14415 ENOG4105D1H recombination factor protein RarA FOC13_RS14425 ENOG4105C3J Cysteine desulfurase FOC13_RS14430 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC13_RS14440 ENOG4105C7H Helicase, RecD TraA family FOC13_RS14445 ENOG41060CR FOC13_RS14460 ENOG4105C02 permease FOC13_RS14470 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC13_RS14490 ENOG4105HHA aminodeoxychorismate lyase FOC13_RS14495 ENOG4108VQJ O-methyltransferase FOC13_RS14500 ENOG4105XYU peptidase (U32 family) FOC13_RS14505 ENOG4105CFP Peptidase U32 FOC13_RS14520 ENOG4107XRG penicillin-binding protein FOC13_RS14550 ENOG4105C28 cystathionine FOC13_RS14555 ENOG4108EKI Dehydrogenase FOC13_RS14565 ENOG4108V5C ABC transporter FOC13_RS14570 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC13_RS14620 ENOG4105MIR Phenylalanine 4-monooxygenase FOC13_RS14625 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC13_RS14660 ENOG4108MUZ hydrolase FOC13_RS14670 ENOG4105G6Z alkaline phosphatase FOC13_RS14685 ENOG4108TVJ Nitroreductase FOC13_RS14705 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_RS14720 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC13_RS14725 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC13_RS14735 ENOG410812S Rna-binding protein FOC13_RS14745 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC13_RS14755 ENOG4105DXX methyltransferase FOC13_RS14765 ENOG4105KQC Competence protein FOC13_RS14770 ENOG4108UK2 deaminase FOC13_RS14775 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC13_RS14785 ENOG4105TQK DNA polymerase iii, delta' subunit FOC13_RS14810 ENOG4105KVH Transcriptional regulator FOC13_RS14815 ENOG4105CSA Coproporphyrinogen iii oxidase FOC13_RS14825 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC13_RS14845 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC13_RS14850 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC13_RS14860 ENOG4105KTH gatB Yqey FOC13_RS14865 ENOG41068P3 sporulation protein YqfC FOC13_RS14875 ENOG4105C9A Phoh family FOC13_RS14880 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC13_RS14890 ENOG4107YR5 Diacylglycerol kinase FOC13_RS14895 ENOG4105KG3 cytidine deaminase FOC13_RS14900 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC13_RS14925 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC13_RS14930 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_RS14945 ENOG4105EGD dinuclear metal center protein, YbgI family FOC13_RS14970 ENOG41069ZM Protein of unknown function (DUF2624) FOC13_RS14975 ENOG4108JYZ YitT family FOC13_RS14980 ENOG4105FDK ABC transporter FOC13_RS14990 ENOG4105N80 Ferric uptake regulator, Fur family FOC13_RS15015 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC13_RS15025 ENOG4107RF6 penicillin-binding protein FOC13_RS15030 ENOG4105PWN phosphate abc transporter FOC13_RS15035 ENOG4105C8U phosphate abc transporter FOC13_RS15040 ENOG4105E2Z phosphate ABC transporter (Permease FOC13_RS15045 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC13_RS15050 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC13_RS15065 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC13_RS15075 ENOG4105DKQ ROK family FOC13_RS15085 ENOG4105C5X domain protein FOC13_RS15105 ENOG4105C28 cystathionine FOC13_RS15110 ENOG4105C28 cystathionine FOC13_RS15120 ENOG4105C3R Methionine synthase FOC13_RS15125 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC13_RS15245 ENOG4105C0D helicase FOC13_RS15275 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC13_RS15280 ENOG4105CJ1 ABC, transporter FOC13_RS15315 ENOG41080TC multidrug resistance protein FOC13_RS15335 ENOG4105WZW rhodanese family FOC13_RS15340 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC13_RS15360 ENOG4107YBY Hydrolase FOC13_RS15370 ENOG4105CBJ Metal-dependent enzyme FOC13_RS15385 ENOG4105DC7 peptidase M24 FOC13_RS15410 ENOG4105CD2 stage iii sporulation protein aa FOC13_RS15415 ENOG4105KR5 Stage iii sporulation protein FOC13_RS15420 ENOG4108CQH stage III sporulation protein AC FOC13_RS15425 ENOG4105KQ4 Stage iii sporulation protein ad FOC13_RS15435 ENOG410644B Stage III sporulation protein af FOC13_RS15460 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC13_RS15465 ENOG4108ZSR alkaline shock protein FOC13_RS15490 ENOG4105CTB Polyprenyl synthetase FOC13_RS15500 ENOG4105DX0 Hemolysin A FOC13_RS15510 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC13_RS15515 ENOG4105S1Z Stage IV sporulation protein B FOC13_RS15520 ENOG4107QQR Sporulation FOC13_RS15535 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC13_RS15545 ENOG4108JUB Transcriptional regulator FOC13_RS15555 ENOG4107RDP Dehydrogenase FOC13_RS15575 ENOG4105CPP Dehydrogenase, E1 component FOC13_RS15580 ENOG4105C7S Dehydrogenase FOC13_RS15595 ENOG4105G7B Protein of unknown function (DUF2992) FOC13_RS15605 ENOG4108HW3 (ABC) transporter FOC13_RS15610 ENOG4105E5Q amino acid AbC transporter FOC13_RS15615 ENOG4105CDA abc transporter atp-binding protein FOC13_RS15620 ENOG4108QEG Membrane FOC13_RS15625 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC13_RS15640 ENOG4105D9U N-acetyltransferase FOC13_RS15645 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC13_RS15655 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC13_RS15680 ENOG4105EJQ L-serine dehydratase FOC13_RS15685 ENOG4105II7 pyrroline-5-carboxylate reductase FOC13_RS15695 ENOG4108IXY short-chain dehydrogenase reductase FOC13_RS15710 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC13_RS15750 ENOG4105CGH 5'-nucleotidase FOC13_RS15755 ENOG4105DFD Na H antiporter FOC13_RS15765 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC13_RS15775 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC13_RS15780 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC13_RS15785 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC13_RS15790 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC13_RS15810 ENOG4108R6K riboflavin synthase, subunit alpha FOC13_RS15815 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC13_RS15835 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC13_RS15840 ENOG4105ETE Transcriptional regulator (LacI family FOC13_RS15850 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC13_RS15870 ENOG4105RHY Pfam:UPF0157 FOC13_RS15880 ENOG4105CPC Aldo Keto reductase FOC13_RS15900 ENOG4105MZ9 stage II sporulation protein m FOC13_RS15905 ENOG4105I3K Ferric uptake regulator, Fur family FOC13_RS15915 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC13_RS15940 ENOG4105D7N magnesium and cobalt transport protein CorA FOC13_RS15970 ENOG4105DVE abc transporter atp-binding protein FOC13_RS15975 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC13_RS15980 ENOG4105DZ1 carboxypeptidase FOC13_RS15985 ENOG41082AN stage II sporulation protein FOC13_RS15995 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_RS16000 ENOG4105C8J )-transporter FOC13_RS16020 ENOG41090VF Stage v sporulation protein ac FOC13_RS16025 ENOG4105CZ3 stage V sporulation protein ad FOC13_RS16035 ENOG4105G6R Stage v sporulation protein ae FOC13_RS16045 ENOG4105J7I hydrolase FOC13_RS16050 ENOG4105PTM secreted protein FOC13_RS16055 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC13_RS16090 ENOG4105CE4 GlcNAc 6-P deacetylase FOC13_RS16100 ENOG4105FDP GntR family transcriptional regulator FOC13_RS16110 ENOG4105CID antiterminator FOC13_RS16125 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC13_RS16145 ENOG4106TD9 Diguanylate cyclase FOC13_RS16165 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC13_RS16190 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC13_RS16200 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOC13_RS16210 ENOG4105DTD Dehydrogenase FOC13_RS16215 ENOG4105K7K Transcriptional regulator FOC13_RS16255 ENOG4105CHU acetyl-coa acetyltransferase FOC13_RS16300 ENOG4105CG3 alpha amylase, catalytic region FOC13_RS16310 ENOG4107FKK extracellular solute-binding protein family 1 FOC13_RS16320 ENOG4105EG2 ABC transporter, permease FOC13_RS16325 ENOG4105FKQ transcriptional regulator FOC13_RS16330 ENOG4105CHM Aminotransferase FOC13_RS16340 ENOG4108HGU Histidine kinase FOC13_RS16395 ENOG4105UIN FOC13_RS16405 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC13_RS16420 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC13_RS16425 ENOG4105EPM Diguanylate phosphodiesterase FOC13_RS16440 ENOG4107IN1 Protein of unknown function (DUF1797) FOC13_RS16445 ENOG4108XRC Protein of unknown function (DUF458) FOC13_RS16480 ENOG4107ZYR domain protein FOC13_RS16485 ENOG4105CN5 Metallo-Beta-Lactamase FOC13_RS16500 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC13_RS16515 ENOG4105CPP Dehydrogenase, E1 component FOC13_RS16520 ENOG4105C7S Dehydrogenase FOC13_RS16565 ENOG4105CXN decarboxylase FOC13_RS16585 ENOG4105ECY inositol monophosphatase FOC13_RS16595 ENOG4105CI3 gtp-binding protein typa FOC13_RS16600 ENOG4105QA2 FOC13_RS16620 ENOG4108IAB Phoh family FOC13_RS16635 ENOG4105CNI cell division protein FtsW FOC13_RS16640 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC13_RS16690 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC13_RS16705 ENOG4107TB6 phosphoglycerate mutase FOC13_RS16725 ENOG4106H78 methyltransferase FOC13_RS16735 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC13_RS16740 ENOG4105D78 K07001 NTE family protein FOC13_RS16745 ENOG41063PX domain protein FOC13_RS16755 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC13_RS16775 ENOG4108IMY Transcriptional regulator FOC13_RS16820 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_RS16835 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC13_RS16920 ENOG4105CAR Terminase, large subunit FOC13_RS16930 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC13_RS17010 ENOG4105XSJ toxin secretion phage lysis holin FOC13_RS17060 ENOG4105KNH Nucleic acid-binding protein FOC13_RS17100 ENOG41068DC Essential cell division protein (By similarity) FOC13_RS17105 ENOG4105CJN penicillin-binding protein FOC13_RS17110 ENOG4105CJN penicillin-binding protein FOC13_RS17115 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC13_RS17130 ENOG4105CNI cell division protein FtsW FOC13_RS17135 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC13_RS17140 ENOG4105D4A Cell wall formation (By similarity) FOC13_RS17145 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC13_RS17150 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC13_RS17155 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC13_RS17165 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_RS17175 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC13_RS17180 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC13_RS17185 ENOG4105DFA alanine racemase domain protein FOC13_RS17195 ENOG41067XK integral membrane protein FOC13_RS17200 ENOG4105DBK s4 domain protein FOC13_RS17225 ENOG4105C34 Pseudouridine synthase FOC13_RS17250 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC13_RS17305 ENOG4105DC7 peptidase M24 FOC13_RS17310 ENOG4105F23 Fibronectin-binding protein FOC13_RS17320 ENOG4105DSJ YicC domain protein FOC13_RS17340 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC13_RS17345 ENOG4105C25 Primosomal protein n' FOC13_RS17350 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC13_RS17360 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC13_RS17370 ENOG4108ZF3 Phosphatase FOC13_RS17375 ENOG4105D9P serine threonine protein kinase FOC13_RS17380 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC13_RS17385 ENOG4105DJV ribulose-phosphate 3-epimerase FOC13_RS17390 ENOG4105FJ0 thiamine FOC13_RS17405 ENOG4108ZAA Alkaline-shock protein FOC13_RS17410 ENOG4105DP4 dak2 domain fusion protein ylov FOC13_RS17415 ENOG4105CB5 ATP-dependent DNA helicase recG FOC13_RS17430 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC13_RS17435 ENOG4105CHR reductase FOC13_RS17450 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC13_RS17455 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC13_RS17475 ENOG4105VB6 UPF0109 protein FOC13_RS17500 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC13_RS17515 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC13_RS17525 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC13_RS17535 ENOG4108HE4 integrase family FOC13_RS17575 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC13_RS17580 ENOG4105KNE Phosphatidate cytidylyltransferase FOC13_RS17585 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC13_RS17590 ENOG4105DZP Membrane-associated zinc metalloprotease FOC13_RS17600 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC13_RS17610 ENOG4105CHV Transcription elongation factor NusA FOC13_RS17615 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC13_RS17620 ENOG4105VHM ribosomal protein FOC13_RS17630 ENOG4105W7A Protein of unknown function (DUF503) FOC13_RS17640 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC13_RS17645 ENOG4105DTN riboflavin biosynthesis protein ribF FOC13_RS17665 ENOG4105C1V Peptidase, M16 FOC13_RS17675 ENOG4105E35 Dipicolinate synthase subunit A FOC13_RS17680 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC13_RS17685 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC13_RS17695 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC13_RS17705 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC13_RS17715 ENOG4107QZI cell division protein FtsK FOC13_RS17720 ENOG4105FDP GntR family transcriptional regulator FOC13_RS17725 ENOG4105DIH basic membrane FOC13_RS17730 ENOG4108JQ9 ABC transporter FOC13_RS17755 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC13_RS17760 ENOG4105XZV Protein of unknown function (DUF3243) FOC13_RS17775 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC13_RS17800 ENOG4105D48 metallophosphoesterase FOC13_RS17805 ENOG4105MCT stage V sporulation protein S FOC13_RS17810 ENOG4108IGT Dipeptidase FOC13_RS17815 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC13_RS17820 ENOG4105DQU oxidoreductase, subunit beta FOC13_RS17825 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC13_RS17850 ENOG4105DA5 (ABC) transporter FOC13_RS17875 ENOG4107QHE Choloylglycine hydrolase FOC13_RS17885 ENOG410890F Dynamin family FOC13_RS17890 ENOG4105E0M Sulfatase FOC13_RS17895 ENOG4107R6R udp-galactopyranose mutase FOC13_RS17900 ENOG4105F0V Cell wall hydrolase FOC13_RS17925 ENOG4107YEI lmbE family FOC13_RS17930 ENOG4107TTQ Alpha beta hydrolase fold FOC13_RS17945 ENOG41067MG lrgb family FOC13_RS17965 ENOG4105BZU Histidine kinase FOC13_RS17970 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_RS18000 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC13_RS18005 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC13_RS18015 ENOG4105CGK Exodeoxyribonuclease III FOC13_RS18035 ENOG4105E0A ABC, transporter FOC13_RS18040 ENOG4105NIV Esterase FOC13_RS18050 ENOG4105VPX protein, conserved in bacteria FOC13_RS18055 ENOG410681U heavy metal transport detoxification protein FOC13_RS18060 ENOG4105C59 p-type ATPase FOC13_RS18065 ENOG4105K70 DNA-binding protein FOC13_RS18070 ENOG4105TMB Formate nitrite transporter FOC13_RS18085 ENOG4105C85 amino acid FOC13_RS18095 ENOG4108SJC Membrane FOC13_RS18105 ENOG4105E98 transcriptional regulator DeoR family FOC13_RS18110 ENOG4105DE4 1-phosphofructokinase FOC13_RS18115 ENOG4105DM4 PTS System FOC13_RS18120 ENOG41069ER domain protein FOC13_RS18150 ENOG4106F1P AAA ATPase, central domain protein FOC13_RS18160 ENOG4105EN6 Membrane FOC13_RS18170 ENOG4105CXI aluminum resistance protein FOC13_RS18175 ENOG4105KV4 Transcriptional regulator FOC13_RS18180 ENOG4105C5F glutamine synthetase FOC13_RS18280 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC13_RS18460 ENOG4105XSJ toxin secretion phage lysis holin FOC13_RS18465 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC13_RS18495 ENOG4105K7K Transcriptional regulator FOC13_RS18515 ENOG4108SVB resolvase FOC13_RS18535 ENOG4105D5T phosphonate abc transporter FOC13_RS18550 ENOG4105D7V transposase FOC13_RS18570 ENOG4105BZ1 (ABC) transporter FOC13_RS18575 ENOG4105BZ1 (ABC) transporter FOC13_RS18590 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC13_RS18615 ENOG41067MG lrgb family FOC13_RS18620 ENOG4105VAW lrga family FOC13_RS18625 ENOG4107RSM transcriptional regulator FOC13_RS18635 ENOG4107QIV Cytochrome c biogenesis protein FOC13_RS18690 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC13_RS18715 ENOG4108903 Formimidoylglutamase FOC13_RS18720 ENOG4108VJ1 Transcriptional regulator (CarD family FOC13_RS18725 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC13_RS18730 ENOG4105CBC glutamate synthase FOC13_RS18735 ENOG4105CK7 Sodium proline symporter FOC13_RS18740 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC13_RS18745 ENOG4105FBA Phospholipase Carboxylesterase FOC13_RS18750 ENOG4105BZU Histidine kinase FOC13_RS18760 ENOG4107AYK membrAne FOC13_RS18810 ENOG4105CEY Amp-dependent synthetase and ligase FOC13_RS18815 ENOG4107ZYJ bioY protein FOC13_RS18820 ENOG4107F3J Amp-dependent synthetase and ligase FOC13_RS18840 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC13_RS18880 ENOG4108I0Z Aconitate hydratase FOC13_RS18885 ENOG4108JJA ABC, transporter FOC13_RS18895 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC13_RS18900 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC13_RS18930 ENOG4105W8X HesB YadR YfhF-family protein FOC13_RS18935 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC13_RS18940 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC13_RS18950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_RS18955 ENOG4105C0H protease FOC13_RS18960 ENOG4105K4P CoA-binding domain protein FOC13_RS18965 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC13_RS18975 ENOG4105D9R oxidoreductase FOC13_RS18985 ENOG4105CIG ABC transporter FOC13_RS19000 ENOG4105EMN RNA polymerase sigma factor FOC13_RS19010 ENOG4108KGH TRANSCRIPTIONal FOC13_RS19075 ENOG4105E1K spore germination protein FOC13_RS19080 ENOG4108JB9 formate dehydrogenase FOC13_RS19090 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC13_RS19095 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC13_RS19105 ENOG4105TMB Formate nitrite transporter FOC13_RS19110 ENOG4105D06 uba thif-type nad fad binding protein FOC13_RS19115 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC13_RS19120 ENOG4108ZAF Molybdopterin FOC13_RS19130 ENOG4105D1F ATP-binding protein FOC13_RS19145 ENOG410696E Membrane FOC13_RS19150 ENOG4105FR1 rard protein FOC13_RS19160 ENOG4105EWU Squalene--hopene cyclase FOC13_RS19170 ENOG4105CHR reductase FOC13_RS19175 ENOG4105C26 Dehydrogenase FOC13_RS19185 ENOG4108IA2 Sodium pantothenate symporter FOC13_RS19200 ENOG4106IQC argininosuccinate lyase FOC13_RS19210 ENOG410904N short-chain dehydrogenase reductase FOC13_RS19230 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC13_RS19250 ENOG4105VEQ Cold shock protein FOC13_RS19265 ENOG4108R1P FOC13_RS19275 ENOG41073R8 VanW family FOC13_RS19280 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_RS19295 ENOG4105KT7 mgtC SapB transporter FOC13_RS19305 ENOG4105E39 Enoyl-CoA hydratase FOC13_RS19310 ENOG4105K64 Glycosyl transferase, family 2 FOC13_RS19320 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC13_RS19340 ENOG4105CQB FAD linked oxidase domain protein FOC13_RS19345 ENOG4105C09 Bile acid FOC13_RS19355 ENOG4105RHY Pfam:UPF0157 FOC13_RS19380 ENOG4105CIS alcohol dehydrogenase FOC13_RS19385 ENOG41082BM Transcriptional regulator, arsr family FOC13_RS19410 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC13_RS19440 ENOG4108A04 Beta-lactamase FOC13_RS19445 ENOG4105DPN Oligoendopeptidase f FOC13_RS19455 ENOG4105E5K Alpha-amylase FOC13_RS19465 ENOG4105C98 muts2 protein FOC13_RS19485 ENOG4107V2S Transcriptional regulator FOC13_RS19495 ENOG4107CUJ Protein of unknown function (DUF2690) FOC13_RS19515 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC13_RS19520 ENOG4105NX3 Membrane FOC13_RS19525 ENOG4105DQ5 transport system permease protein FOC13_RS19530 ENOG4105EHG Permease protein FOC13_RS19535 ENOG4108MES Periplasmic binding protein FOC13_RS19555 ENOG4107R3E Citrate transporter FOC13_RS19565 ENOG4108TN2 lmbE family FOC13_RS19635 ENOG4105H3G oxidoreductase FOC13_RS19645 ENOG4105ED2 Beta-lactamase FOC13_RS19670 ENOG4107YXZ hydrolase, family 25 FOC13_RS19685 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC13_RS19710 ENOG4105KAF membrAne FOC13_RS19780 ENOG4105KVH Transcriptional regulator FOC13_RS19800 ENOG4105CHR reductase FOC13_RS19810 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC13_RS19845 ENOG4105KVH Transcriptional regulator FOC13_RS19850 ENOG4105KVH Transcriptional regulator FOC13_RS19855 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC13_RS19865 ENOG4108TZY GntR Family Transcriptional Regulator FOC13_RS19870 ENOG4105KVH Transcriptional regulator FOC13_RS19900 ENOG4105C44 Serine transporter FOC13_RS19905 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC13_RS19920 ENOG4105F27 Major Facilitator FOC13_RS19925 ENOG4105CV8 reductase FOC13_RS19945 ENOG4105D4Y metalloprotease FOC13_RS19950 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC13_RS19965 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC13_RS19970 ENOG4105CIS alcohol dehydrogenase FOC13_RS19975 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC13_RS19980 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC13_RS19995 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC13_RS20000 ENOG4105C6Z Gluconate FOC13_RS20005 ENOG4105CMG Carbohydrate kinase FOC13_RS20010 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC13_RS20015 ENOG4105XDF Protein of unknown function (DUF1272) FOC13_RS20020 ENOG4105DDN Pentapeptide repeat-containing protein FOC13_RS20035 ENOG4105C37 (CBS) domain FOC13_RS20065 ENOG4105EV4 Multidrug resistance protein mdtH FOC13_RS20075 ENOG4105DMQ Methyltransferase FOC13_RS20095 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC13_RS20100 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC13_RS20105 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC13_RS20115 ENOG4108UW5 maltose o-acetyltransferase FOC13_RS20120 ENOG4106UW1 Major Facilitator superfamily FOC13_RS20125 ENOG4105DKQ ROK family FOC13_RS20130 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_RS20190 ENOG4105CJ1 ABC, transporter FOC13_RS20200 ENOG4108PSK reductase FOC13_RS20220 ENOG4108RCM Nitroreductase FOC13_RS20225 ENOG4105KVH Transcriptional regulator FOC13_RS20240 ENOG4105CUT histidyl-tRNA synthetase FOC13_RS20245 ENOG4108Z66 YbaK ebsC protein FOC13_RS20255 ENOG41067QW Transcriptional regulator FOC13_RS20270 ENOG4108K8S endonuclease I FOC13_RS20295 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC13_RS20300 ENOG4108JJB ABC transporter FOC13_RS20330 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC13_RS20340 ENOG4105CRW Short chain fatty acid transporter FOC13_RS20350 ENOG4105KBX Transcriptional regulator, TetR family FOC13_RS20355 ENOG4105KPY Small multidrug resistance protein FOC13_RS20360 ENOG4105RXJ FOC13_RS20370 ENOG41069JR FOC13_RS20375 ENOG4105DA5 (ABC) transporter FOC13_RS20395 ENOG4105CZM Major Facilitator FOC13_RS20400 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC13_RS20410 ENOG4108ISG Major Facilitator FOC13_RS20460 ENOG410874W AraC family transcriptional regulator FOC13_RS20465 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC13_RS20480 ENOG4108AEY RNA polymerase sigma factor FOC13_RS20500 ENOG4108JQ1 Dehydrogenase FOC13_RS20515 ENOG4105DVH amino acid FOC13_RS20525 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC13_RS20540 ENOG4108JPW Aminotransferase FOC13_RS20555 ENOG4105EJQ L-serine dehydratase FOC13_RS20560 ENOG4105C44 Serine transporter FOC13_RS20575 ENOG4108JGH Tetr family transcriptional regulator FOC13_RS20580 ENOG4105EQ0 Major Facilitator superfamily FOC13_RS20600 ENOG4107QJQ Mate efflux family protein FOC13_RS20630 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC13_RS20660 ENOG4105TRI Hydrolase FOC13_RS20690 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC13_RS20700 ENOG4106P55 Transcriptional regulator FOC13_RS20710 ENOG4107QR9 Iron-sulfur cluster binding protein FOC13_RS20715 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC13_RS20720 ENOG4105DJB Major Facilitator Superfamily FOC13_RS20725 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC13_RS20740 ENOG4108U05 Transcriptional regulator FOC13_RS20755 ENOG4105BZU Histidine kinase FOC13_RS20770 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC13_RS20775 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC13_RS20790 ENOG4105JQZ Methyltransferase FOC13_RS20795 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC13_RS20805 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC13_RS20810 ENOG4108NNI Beta-lactamase domain-containing protein FOC13_RS20825 ENOG4105VZ8 Transcriptional regulator FOC13_RS20845 ENOG4105K6H D-cysteine desulfhydrase FOC13_RS20870 ENOG41062D9 Histidine kinase FOC13_RS20875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_RS20890 ENOG4105IIP Membrane FOC13_RS20900 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC13_RS20905 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC13_RS20980 ENOG4108YXU transcriptional regulator AsnC family FOC13_RS20985 ENOG4105CHR reductase FOC13_RS20995 ENOG4105F7F Chaperone FOC13_RS21010 ENOG41085FC arsR family transcriptional regulator FOC13_RS21015 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_RS21020 ENOG4105D6J arsenicaL-resistance protein FOC13_RS21050 ENOG4105DIK (ABC) transporter FOC13_RS21055 ENOG4105CC5 ABC transporter FOC13_RS21060 ENOG4105DSE periplasmic solute binding protein FOC13_RS21065 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC13_RS21070 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC13_RS21085 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC13_RS21090 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC13_RS21105 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC13_RS21110 ENOG4108606 TspO/MBR family FOC13_RS21145 ENOG41090MY MarR family Transcriptional regulator FOC13_RS21170 ENOG4105CHJ isochorismatase hydrolase FOC13_RS21180 ENOG4105CH6 catalase FOC13_RS21185 ENOG4105CGH 5'-nucleotidase FOC13_RS21220 ENOG4105CSV Glutaminase FOC13_RS21255 ENOG4105C6K Malic enzyme FOC13_RS21265 ENOG4105II7 pyrroline-5-carboxylate reductase FOC13_RS21275 ENOG4105CUB amino acid FOC13_RS21280 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC13_RS21290 ENOG4108IMY Transcriptional regulator FOC13_RS21295 ENOG4105HDK L-asparaginase FOC13_RS21300 ENOG4108IJ0 Aspartate ammonia-lyase FOC13_RS21315 ENOG4105E2A Dehydrogenase FOC13_RS21375 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC13_RS21405 ENOG4105DWD nucleoside recognition domain protein FOC13_RS21420 ENOG4105FDT acyl-CoA dehydrogenase FOC13_RS21430 ENOG4108ZHR arsR family transcriptional regulator FOC13_RS21435 ENOG4108ZRV stage ii sporulation protein p FOC13_RS21440 ENOG4106N3A copper homeostasis protein cutc FOC13_RS21450 ENOG4107258 Transcriptional regulator FOC13_RS21455 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC13_RS21490 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC13_RS21535 ENOG4105F1N DNA alkylation repair FOC13_RS21545 ENOG4108IQI permease FOC13_RS21550 ENOG4105KNA -acetyltransferase FOC13_RS21555 ENOG410635A Membrane FOC13_RS21635 ENOG4108XET gCN5-related N-acetyltransferase FOC13_RS21665 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC13_RS21675 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC13_RS21710 ENOG4105FS7 Transcriptional regulator FOC13_RS21715 ENOG4108TVJ Nitroreductase FOC13_RS21725 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC13_RS21765 ENOG4105C8Y Acetylornithine aminotransferase FOC13_RS21775 ENOG4105CKK Glycosyl transferase, family 2 FOC13_RS21800 ENOG4105CKK Glycosyl transferase, family 2 FOC13_RS21825 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC13_RS21850 ENOG41068WN FOC13_RS21860 ENOG4108WCX response regulator FOC13_RS21870 ENOG41090T1 Membrane FOC13_RS21885 ENOG4105VMP Transcriptional regulator FOC13_RS21895 ENOG4105G6Z alkaline phosphatase FOC13_RS21900 ENOG4105ECK Fatty Acid Desaturase FOC13_RS21905 ENOG4105E0Y RtcB Protein FOC13_RS21915 ENOG4107258 Transcriptional regulator FOC13_RS21925 ENOG4105II7 pyrroline-5-carboxylate reductase FOC13_RS21930 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC13_RS21960 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC13_RS21980 ENOG41061GT Aldolase FOC13_RS21995 ENOG4105DKT Transcriptional regulator FOC13_RS22005 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC13_RS22015 ENOG4105D4B ABC, transporter FOC13_RS22040 ENOG4105EMN RNA polymerase sigma factor FOC13_RS22050 ENOG41069ER domain protein FOC13_RS22085 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC13_RS22090 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC13_RS22095 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC13_RS22115 ENOG41082JN Transcriptional regulator FOC13_RS22120 ENOG4105EYF MMPL domain protein FOC13_RS22125 ENOG4105EYF MMPL domain protein FOC13_RS22130 ENOG4105EYF MMPL domain protein FOC13_RS22140 ENOG4105C5H ABC transporter FOC13_RS22145 ENOG4105E0M Sulfatase FOC13_RS22150 ENOG4108ZCF integral membrane protein FOC13_RS22160 ENOG4107VMI polysaccharide deacetylase FOC13_RS22170 ENOG4107VC0 DNA alkylation repair enzyme FOC13_RS22220 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC13_RS22240 ENOG4105E09 nadh pyrophosphatase FOC13_RS22265 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC13_RS22270 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC13_RS22275 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC13_RS22285 ENOG4105C02 permease FOC13_RS22355 ENOG4105CHM Aminotransferase FOC13_RS22390 ENOG41089UC methyltransferase, type 11 FOC13_RS22405 ENOG4107BMA Transglycosylase associated protein FOC13_RS22425 ENOG4106K7D Major facilitator family transporter FOC13_RS22430 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC13_RS22470 ENOG4105EPR degv family FOC13_RS22485 ENOG4105DPN Oligoendopeptidase f FOC13_RS22525 ENOG4105BZU Histidine kinase FOC13_RS22530 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC13_RS22575 ENOG4105DTQ mandelate racemase muconate lactonizing FOC13_RS22590 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC13_RS22595 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC13_RS22610 ENOG4107T5V SNARE associated Golgi FOC13_RS22650 ENOG41080HI glycine oxidase FOC13_RS22655 ENOG4105CTU Proline racemase FOC13_RS22660 ENOG4105CTU Proline racemase FOC13_RS22665 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC13_RS22670 ENOG4105C26 Dehydrogenase FOC13_RS22675 ENOG4105BZG amino acid carrier protein FOC13_RS22695 ENOG4108M1A Chitin-binding protein FOC13_RS22740 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC13_RS22760 ENOG4105EEM helicase FOC13_RS22810 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC13_RS22845 ENOG4108M1A Chitin-binding protein FOC13_RS22850 ENOG41082BV acetyltransferase FOC13_RS22855 ENOG4105E66 phosphoriboisomerase A FOC13_RS22880 ENOG4108IJ7 Glycine betaine FOC13_RS22885 ENOG4107SQ8 Glycine betaine FOC13_RS22915 ENOG4105RHY Pfam:UPF0157 FOC13_RS22920 ENOG4105E1F short-chain dehydrogenase reductase FOC13_RS22930 ENOG4107RUY (E1 component), alpha subunit FOC13_RS22940 ENOG4107QKR Dehydrogenase FOC13_RS22960 ENOG41062ES Transcriptional regulator FOC13_RS22980 ENOG4105E98 transcriptional regulator DeoR family FOC13_RS22995 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC13_RS23025 ENOG4107Z3H Transcriptional regulator, TetR family FOC13_RS23030 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC13_RS23035 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC13_RS23040 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC13_RS23060 ENOG4105MSI germination protein ypeb FOC13_RS23080 ENOG4108V3A UPF0421 protein FOC13_RS23115 ENOG4105FDR Membrane FOC13_RS23125 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC13_RS23150 ENOG4108IUM Glycogen debranching enzyme FOC13_RS23165 ENOG4105DY8 decarboxylase FOC13_RS23185 ENOG4105PAD Hydrolase FOC13_RS23210 ENOG4107VFR oxidoreductase FOC13_RS23250 ENOG4105PKS Excinuclease abc c subunit domain protein FOC13_RS23285 ENOG4105KWG Pfam:DUF1696 FOC13_RS23315 ENOG4108XI2 Domain of unknown function (DUF1963) FOC13_RS23350 ENOG4108Z4K mutator MutT protein FOC13_RS23355 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC13_RS23360 ENOG4105E09 nadh pyrophosphatase FOC13_RS23375 ENOG4105FCD Major Facilitator FOC13_RS23405 ENOG4107Y9U Membrane FOC13_RS23425 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC13_RS23440 ENOG4107Y80 Major Facilitator superfamily FOC13_RS23470 ENOG4108V4B ThiJ pfpI FOC13_RS23505 ENOG4105FQP Beta-lactamase FOC13_RS23515 ENOG4105CJN penicillin-binding protein FOC13_RS23520 ENOG4105CB2 alcohol dehydrogenase FOC13_RS23535 ENOG4108HGU Histidine kinase FOC13_RS23550 ENOG4108JJB ABC transporter FOC13_RS23570 ENOG4107RF6 penicillin-binding protein FOC13_RS23575 ENOG4105BZU Histidine kinase FOC13_RS23585 ENOG410667J hydrolase FOC13_RS23685 ENOG4105ETU transcriptional activator (TenA FOC13_RS23790 ENOG4105CPQ Dehydrogenase FOC13_RS23825 ENOG4105CUV Homoserine Kinase FOC13_RS23840 ENOG4107Y80 Major Facilitator superfamily FOC13_RS23850 ENOG4105FQP Beta-lactamase FOC13_RS23865 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC13_RS23865 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC13_RS23905 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC13_RS23915 ENOG4105T9C HD domain FOC13_RS23930 ENOG4105DZ1 carboxypeptidase FOC13_RS23945 ENOG4105DBI uridine monophosphokinase FOC13_RS23950 ENOG4105WCN acetyltransferase FOC13_RS23960 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC13_RS23965 ENOG4107QX3 carboxylase FOC13_RS23970 ENOG4105E39 Enoyl-CoA hydratase FOC13_RS23975 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC13_RS23980 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC13_RS23985 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC13_RS23990 ENOG4105C1G acyl-Coa dehydrogenase FOC13_RS24005 ENOG4107Z3H Transcriptional regulator, TetR family FOC13_RS24015 ENOG4105CJ1 ABC, transporter FOC13_RS24030 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC13_RS24035 ENOG4105CEP NADH dehydrogenase FOC13_RS24040 ENOG4106ANW SMI1_KNR4 FOC13_RS24055 ENOG4105BZU Histidine kinase FOC13_RS24065 ENOG4105C5H ABC transporter FOC13_RS24070 ENOG41067SE Tetr family transcriptional regulator FOC13_RS24090 ENOG4108VXD carboxy-peptidase FOC13_RS24105 ENOG4105VZ8 Transcriptional regulator FOC13_RS24135 ENOG4105DH8 myo-inositol catabolism FOC13_RS24140 ENOG4105D2N Aldolase FOC13_RS24165 ENOG4105CK5 oxidoreductase FOC13_RS24170 ENOG4105IE8 Alpha-ketoglutarate permease FOC13_RS24175 ENOG4105ETE Transcriptional regulator (LacI family FOC13_RS24180 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC13_RS24195 ENOG4107RF6 penicillin-binding protein FOC13_RS24220 ENOG4105CIN aminoacyl-histidine dipeptidase FOC13_RS24250 ENOG41090HR transcriptional regulator FOC13_RS24255 ENOG4107RA9 decarboxylase FOC13_RS24260 ENOG4108I0C methyltransferase FOC13_RS24270 ENOG41088CC tellurite resistance protein tehB FOC13_RS24290 ENOG4108RZE Tetr family transcriptional regulator FOC13_RS24305 ENOG4105C1J atp-dependent rna helicase FOC13_RS24320 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC13_RS24340 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC13_RS24350 ENOG4105RD7 BadF BadG BcrA BcrD FOC13_RS24400 ENOG4108KPJ rna polymerase sigma factor FOC13_RS24430 ENOG4108JCI Transcriptional regulator FOC13_RS24450 ENOG4105BZ1 (ABC) transporter FOC13_RS24455 ENOG4105BZ1 (ABC) transporter FOC13_RS24470 ENOG4108RPX mosc domain containing protein FOC13_RS24475 ENOG4105DND Transcriptional regulator FOC13_RS24490 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC13_RS24495 ENOG4107V2S Transcriptional regulator FOC13_RS24530 ENOG410667J hydrolase FOC13_RS24550 ENOG4105VEQ Cold shock protein FOC13_RS24560 ENOG41068WN FOC13_RS24570 ENOG4105C1Q protoporphyrinogen oxidase FOC13_RS24600 ENOG4105WCN acetyltransferase FOC13_RS24625 ENOG4105EYF MMPL domain protein FOC13_RS24635 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC13_RS24650 ENOG41081I9 integral membrane protein FOC13_RS24680 ENOG4108D32 Methyltransferase FOC13_RS24705 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC13_RS24720 ENOG4105C22 threonyL-tRNA synthetase FOC13_RS24725 ENOG4105FE9 pseudouridine synthase FOC13_RS24745 ENOG4105BZG amino acid carrier protein FOC13_RS24765 ENOG4105K70 DNA-binding protein FOC13_RS24780 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC13_RS24785 ENOG4105WQT MbtH domain protein FOC13_RS24790 ENOG4105CEY Amp-dependent synthetase and ligase FOC13_RS24795 ENOG4105WQI isochorismatase FOC13_RS24800 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC13_RS24805 ENOG4105E4F Isochorismate synthase FOC13_RS24810 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC13_RS24815 ENOG4105FCD Major Facilitator FOC13_RS24835 ENOG4105EYH Exonuclease FOC13_RS24840 ENOG4107RFY SbcCD D subunit FOC13_RS24855 ENOG4105E39 Enoyl-CoA hydratase FOC13_RS24860 ENOG4105N14 lysine exporter protein LysE YggA FOC13_RS24870 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC13_RS24875 ENOG4105C1G acyl-Coa dehydrogenase FOC13_RS24880 ENOG4105CR4 methylisocitrate lyase FOC13_RS24885 ENOG4105DXD 2-methylcitrate dehydratase FOC13_RS24895 ENOG4105W8X HesB YadR YfhF-family protein FOC13_RS24900 ENOG4105CZM Major Facilitator FOC13_RS24905 ENOG4105BZ4 penicillin-binding protein FOC13_RS24945 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC13_RS25050 ENOG4108IBT Inherit from COG: transposase FOC13_RS25065 ENOG4105SZ6 Thioredoxin FOC13_RS25075 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC13_RS25080 ENOG4108N23 SpoOM-related protein FOC13_RS25120 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC13_RS25125 ENOG4108JUB Transcriptional regulator FOC13_RS25130 ENOG4108TSC N-acetyltransferase FOC13_RS25135 ENOG4107S4Y M20 DapE family protein YgeY FOC13_RS25150 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC13_RS25175 ENOG4105C37 (CBS) domain FOC13_RS25210 ENOG4105E90 ABC transporter FOC13_RS25215 ENOG4108IJ8 ABC transporter FOC13_RS25240 ENOG4105CMG Carbohydrate kinase FOC13_RS25245 ENOG4105CMG Carbohydrate kinase FOC13_RS25280 ENOG4105WH1 Two component transcriptional regulator luxr family FOC13_RS25285 ENOG4105BZU Histidine kinase FOC13_RS25290 ENOG4105D8X mechanosensitive ion channel FOC13_RS25325 ENOG4105F0I Aminotransferase FOC13_RS25330 ENOG4108MES Periplasmic binding protein FOC13_RS25345 ENOG4105CAQ asparagine synthetase FOC13_RS25350 ENOG4107Y70 Heat shock protein FOC13_RS25355 ENOG4108KF3 Electron transport protein SCO1 SenC FOC13_RS25360 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC13_RS25365 ENOG4108RCR degv family FOC13_RS25375 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC13_RS25385 ENOG4108UT2 hemolysin iii FOC13_RS25395 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC13_RS25400 ENOG4107RVG penicillin-binding protein FOC13_RS25415 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC13_RS25435 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC13_RS25465 ENOG4105KD7 acetyltransferase FOC13_RS25480 ENOG4105C0A alcohol dehydrogenase FOC13_RS25485 ENOG4105CY2 Citrate transporter FOC13_RS25490 ENOG4107XGZ Hydrolase FOC13_RS25510 ENOG4105C8J )-transporter FOC13_RS25525 ENOG41062D9 Histidine kinase FOC13_RS25530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_RS25535 ENOG4107QPK )-transporter FOC13_RS25540 ENOG4105BZW Glycerate kinase FOC13_RS25610 ENOG4105EC2 ftsk spoIIIe FOC13_RS25630 ENOG4105C5S asparaginyl-tRNA synthetase FOC13_RS25650 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC13_RS25675 ENOG4105C75 arginyL-tRNA synthetase FOC13_RS25680 ENOG4107YX5 Pfam:DUF548 FOC13_RS25710 ENOG4108UUM single-stranded DNA-binding protein FOC13_RS25725 ENOG4105C5H ABC transporter FOC13_RS25745 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC13_RS25760 ENOG4105MCT stage V sporulation protein S FOC13_RS25795 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC13_RS25800 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC13_RS25805 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC13_RS25810 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC13_RS25815 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC13_RS25820 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC13_RS25845 ENOG4108ZAF Molybdopterin FOC13_RS25850 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC13_RS25855 ENOG4105D06 uba thif-type nad fad binding protein FOC13_RS25860 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC13_RS25865 ENOG4107V6Q Cyclic nucleotide-binding domain FOC13_RS25890 ENOG4105R3A Nitrate reductase FOC13_RS25895 ENOG4108IUE nitrate reductase beta subunit FOC13_RS25915 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC13_RS25930 ENOG4108V06 Glutathione peroxidase FOC13_RS25955 ENOG4105EMN RNA polymerase sigma factor FOC13_RS25960 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC13_RS25970 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_RS25995 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC13_RS26020 ENOG4105KBJ sporulation protein ytfj FOC13_RS26070 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC13_RS26095 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC13_RS26100 ENOG4108JYZ YitT family FOC13_RS26105 ENOG41087PP glycosyltransferase MGT family FOC13_RS26120 ENOG4107RBS Methyltransferase FOC13_RS26125 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC13_RS26135 ENOG4108X4Q Hydrolase FOC13_RS26160 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC13_RS26170 ENOG4108VXD carboxy-peptidase FOC13_RS26180 ENOG4108ZRV stage ii sporulation protein p FOC13_RS26200 ENOG4108Z7R Chaperone CsaA FOC13_RS26220 ENOG4105C37 (CBS) domain FOC13_RS26225 ENOG4105SXS Protein of unknown function (DUF456) FOC13_RS26245 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC13_RS26255 ENOG4108S4H thioesterase Superfamily protein FOC13_RS26265 ENOG4108PJD permease FOC13_RS26280 ENOG4107T5V SNARE associated Golgi FOC13_RS26300 ENOG4105CVJ phosphoglycerate mutase FOC13_RS26325 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC13_RS26335 ENOG4105K4T epimerase FOC13_RS26340 ENOG4105DSE periplasmic solute binding protein FOC13_RS26395 ENOG4105CKI cobalamin synthesis protein FOC13_RS26400 ENOG4107QM2 Aldo Keto reductase FOC13_RS26420 ENOG4105DEN Luciferase family FOC13_RS26435 ENOG4108WPJ Ferritin-like domain FOC13_RS26440 ENOG4108K88 Membrane FOC13_RS26455 ENOG4105C8Q Methyl-accepting chemotaxis FOC13_RS26480 ENOG4107XZQ multidrug resistance protein FOC13_RS26485 ENOG4107SET aldo keto reductase FOC13_RS26490 ENOG4105YVS arsR family transcriptional regulator FOC13_RS26500 ENOG4105KRN Transcriptional regulator, abrb family FOC13_RS26550 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC13_RS26560 ENOG4105YWU small acid-soluble spore protein FOC13_RS26565 ENOG4108WBH protein TIM barrel FOC13_RS26580 ENOG4105CEY Amp-dependent synthetase and ligase FOC13_RS26585 ENOG4105DUU IucA IucC family protein FOC13_RS26595 ENOG4105VRR gCN5-related N-acetyltransferase FOC13_RS26600 ENOG4105KT7 mgtC SapB transporter FOC13_RS26610 ENOG4107VMI polysaccharide deacetylase FOC13_RS26615 ENOG4105BZU Histidine kinase FOC13_RS26620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_RS26630 ENOG4108KGH TRANSCRIPTIONal FOC13_RS26655 ENOG4105D6E homoserine dehydrogenase FOC13_RS26675 ENOG4108ZJ4 polysaccharide deacetylase FOC13_RS26680 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC13_RS26700 ENOG4105BZU Histidine kinase FOC13_RS26705 ENOG4105EFI regulatoR FOC13_RS26755 ENOG4108JJ8 (ABC) transporter FOC13_RS26760 ENOG4108JJ9 ABC, transporter FOC13_RS26765 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC13_RS26770 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC13_RS26780 ENOG4105YGB Transcriptional regulator FOC13_RS26790 ENOG4105MDS 4-oxalocrotonate tautomerase FOC13_RS26800 ENOG4105SKE transcriptional Regulator LysR family FOC13_RS26810 ENOG4105C32 Amino acid ABC transporter (Permease) FOC13_RS26815 ENOG4108IV0 ABC, transporter FOC13_RS26820 ENOG4105C0Z ABC transporter FOC13_RS26830 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC13_RS26835 ENOG4108Z7G MaoC domain protein dehydratase FOC13_RS26855 ENOG4105CKI cobalamin synthesis protein FOC13_RS26865 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC13_RS26870 ENOG4106F5Q Membrane FOC13_RS26875 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC13_RS26880 ENOG4108TVJ Nitroreductase FOC13_RS26885 ENOG4107ZXU DSBA oxidoreductase FOC13_RS26890 ENOG4108Z40 Transcriptional regulator FOC13_RS26895 ENOG4105GZI Transcriptional regulator FOC13_RS26900 ENOG4107RT3 EamA-like transporter family FOC13_RS26910 ENOG4105KTB nuclear export factor GLE1 FOC13_RS26915 ENOG4108T5E Copper resistance protein FOC13_RS26960 ENOG4107STQ Multicopper oxidase FOC13_RS26965 ENOG4107RAQ aminopeptidase FOC13_RS27000 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC13_RS27005 ENOG4105D9N nucleoside FOC13_RS27015 ENOG4107RHR regulatoR FOC13_RS27045 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC13_RS27055 ENOG4105C72 UPF0176 protein FOC13_RS27060 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC13_RS27095 ENOG4108QY5 Ferric enterobactin transport protein