locus-tag class description FOC14_RS00015 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC14_RS00025 ENOG4105EYF MMPL domain protein FOC14_RS00050 ENOG4105WCN acetyltransferase FOC14_RS00080 ENOG4105C1Q protoporphyrinogen oxidase FOC14_RS00090 ENOG41068WN FOC14_RS00100 ENOG4105VEQ Cold shock protein FOC14_RS00120 ENOG410667J hydrolase FOC14_RS00155 ENOG4107V2S Transcriptional regulator FOC14_RS00160 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC14_RS00175 ENOG4105DND Transcriptional regulator FOC14_RS00180 ENOG4108RPX mosc domain containing protein FOC14_RS00195 ENOG4105BZ1 (ABC) transporter FOC14_RS00200 ENOG4105BZ1 (ABC) transporter FOC14_RS00220 ENOG4108JCI Transcriptional regulator FOC14_RS00250 ENOG4108KPJ rna polymerase sigma factor FOC14_RS00300 ENOG4105RD7 BadF BadG BcrA BcrD FOC14_RS00310 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC14_RS00330 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC14_RS00345 ENOG4105C1J atp-dependent rna helicase FOC14_RS00360 ENOG4108RZE Tetr family transcriptional regulator FOC14_RS00380 ENOG41088CC tellurite resistance protein tehB FOC14_RS00390 ENOG4108I0C methyltransferase FOC14_RS00395 ENOG4107RA9 decarboxylase FOC14_RS00400 ENOG41090HR transcriptional regulator FOC14_RS00430 ENOG4105CIN aminoacyl-histidine dipeptidase FOC14_RS00455 ENOG4107RF6 penicillin-binding protein FOC14_RS00470 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC14_RS00475 ENOG4105ETE Transcriptional regulator (LacI family FOC14_RS00480 ENOG4105IE8 Alpha-ketoglutarate permease FOC14_RS00485 ENOG4105CK5 oxidoreductase FOC14_RS00510 ENOG4105D2N Aldolase FOC14_RS00515 ENOG4105DH8 myo-inositol catabolism FOC14_RS00545 ENOG4105VZ8 Transcriptional regulator FOC14_RS00560 ENOG4108VXD carboxy-peptidase FOC14_RS00580 ENOG41067SE Tetr family transcriptional regulator FOC14_RS00585 ENOG4105C5H ABC transporter FOC14_RS00595 ENOG4105BZU Histidine kinase FOC14_RS00610 ENOG4106ANW SMI1_KNR4 FOC14_RS00615 ENOG4105CEP NADH dehydrogenase FOC14_RS00620 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC14_RS00635 ENOG4105CJ1 ABC, transporter FOC14_RS00645 ENOG4107Z3H Transcriptional regulator, TetR family FOC14_RS00660 ENOG4105C1G acyl-Coa dehydrogenase FOC14_RS00665 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC14_RS00670 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC14_RS00675 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC14_RS00680 ENOG4105E39 Enoyl-CoA hydratase FOC14_RS00685 ENOG4107QX3 carboxylase FOC14_RS00690 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC14_RS00700 ENOG4105WCN acetyltransferase FOC14_RS00705 ENOG4105DBI uridine monophosphokinase FOC14_RS00720 ENOG4105DZ1 carboxypeptidase FOC14_RS00735 ENOG4105T9C HD domain FOC14_RS00745 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC14_RS00785 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC14_RS00785 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC14_RS00800 ENOG4105FQP Beta-lactamase FOC14_RS00810 ENOG4107Y80 Major Facilitator superfamily FOC14_RS00825 ENOG4105CUV Homoserine Kinase FOC14_RS00860 ENOG4105CPQ Dehydrogenase FOC14_RS00965 ENOG4105ETU transcriptional activator (TenA FOC14_RS01065 ENOG410667J hydrolase FOC14_RS01075 ENOG4105BZU Histidine kinase FOC14_RS01080 ENOG4107RF6 penicillin-binding protein FOC14_RS01100 ENOG4108JJB ABC transporter FOC14_RS01115 ENOG4108HGU Histidine kinase FOC14_RS01130 ENOG4105CB2 alcohol dehydrogenase FOC14_RS01135 ENOG4105CJN penicillin-binding protein FOC14_RS01145 ENOG4105FQP Beta-lactamase FOC14_RS01180 ENOG4108V4B ThiJ pfpI FOC14_RS01210 ENOG4107Y80 Major Facilitator superfamily FOC14_RS01225 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC14_RS01245 ENOG4107Y9U Membrane FOC14_RS01275 ENOG4105FCD Major Facilitator FOC14_RS01290 ENOG4105E09 nadh pyrophosphatase FOC14_RS01295 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC14_RS01300 ENOG4108Z4K mutator MutT protein FOC14_RS01335 ENOG4108XI2 Domain of unknown function (DUF1963) FOC14_RS01365 ENOG4105KWG Pfam:DUF1696 FOC14_RS01400 ENOG4105PKS Excinuclease abc c subunit domain protein FOC14_RS01440 ENOG4107VFR oxidoreductase FOC14_RS01465 ENOG4105PAD Hydrolase FOC14_RS01485 ENOG4105DY8 decarboxylase FOC14_RS01500 ENOG4108IUM Glycogen debranching enzyme FOC14_RS01525 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC14_RS01535 ENOG4105FDR Membrane FOC14_RS01570 ENOG4108V3A UPF0421 protein FOC14_RS01590 ENOG4105MSI germination protein ypeb FOC14_RS01610 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC14_RS01615 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC14_RS01620 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC14_RS01625 ENOG4107Z3H Transcriptional regulator, TetR family FOC14_RS01655 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC14_RS01670 ENOG4105E98 transcriptional regulator DeoR family FOC14_RS01690 ENOG41062ES Transcriptional regulator FOC14_RS01710 ENOG4107QKR Dehydrogenase FOC14_RS01720 ENOG4107RUY (E1 component), alpha subunit FOC14_RS01730 ENOG4105E1F short-chain dehydrogenase reductase FOC14_RS01735 ENOG4105RHY Pfam:UPF0157 FOC14_RS01765 ENOG4107SQ8 Glycine betaine FOC14_RS01770 ENOG4108IJ7 Glycine betaine FOC14_RS01795 ENOG4105E66 phosphoriboisomerase A FOC14_RS01800 ENOG41082BV acetyltransferase FOC14_RS01805 ENOG4108M1A Chitin-binding protein FOC14_RS01840 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC14_RS01890 ENOG4105EEM helicase FOC14_RS01910 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC14_RS01955 ENOG4108M1A Chitin-binding protein FOC14_RS01975 ENOG4105BZG amino acid carrier protein FOC14_RS01980 ENOG4105C26 Dehydrogenase FOC14_RS01985 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC14_RS01990 ENOG4105CTU Proline racemase FOC14_RS01995 ENOG4105CTU Proline racemase FOC14_RS02000 ENOG41080HI glycine oxidase FOC14_RS02040 ENOG4107T5V SNARE associated Golgi FOC14_RS02055 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC14_RS02060 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC14_RS02075 ENOG4105DTQ mandelate racemase muconate lactonizing FOC14_RS02120 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC14_RS02125 ENOG4105BZU Histidine kinase FOC14_RS02165 ENOG4105DPN Oligoendopeptidase f FOC14_RS02180 ENOG4105EPR degv family FOC14_RS02220 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC14_RS02225 ENOG4106K7D Major facilitator family transporter FOC14_RS02245 ENOG4107BMA Transglycosylase associated protein FOC14_RS02260 ENOG41089UC methyltransferase, type 11 FOC14_RS02295 ENOG4105CHM Aminotransferase FOC14_RS02365 ENOG4105C02 permease FOC14_RS02375 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC14_RS02380 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC14_RS02385 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC14_RS02410 ENOG4105E09 nadh pyrophosphatase FOC14_RS02430 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC14_RS02480 ENOG4107VC0 DNA alkylation repair enzyme FOC14_RS02490 ENOG4107VMI polysaccharide deacetylase FOC14_RS02500 ENOG4108ZCF integral membrane protein FOC14_RS02505 ENOG4105E0M Sulfatase FOC14_RS02510 ENOG4105C5H ABC transporter FOC14_RS02520 ENOG4105EYF MMPL domain protein FOC14_RS02525 ENOG4105EYF MMPL domain protein FOC14_RS02530 ENOG4105EYF MMPL domain protein FOC14_RS02535 ENOG41082JN Transcriptional regulator FOC14_RS02555 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC14_RS02560 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC14_RS02565 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC14_RS02600 ENOG41069ER domain protein FOC14_RS02610 ENOG4105EMN RNA polymerase sigma factor FOC14_RS02635 ENOG4105D4B ABC, transporter FOC14_RS02645 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC14_RS02655 ENOG4105DKT Transcriptional regulator FOC14_RS02670 ENOG41061GT Aldolase FOC14_RS02690 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC14_RS02720 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC14_RS02725 ENOG4105II7 pyrroline-5-carboxylate reductase FOC14_RS02735 ENOG4107258 Transcriptional regulator FOC14_RS02745 ENOG4105E0Y RtcB Protein FOC14_RS02750 ENOG4105ECK Fatty Acid Desaturase FOC14_RS02755 ENOG4105G6Z alkaline phosphatase FOC14_RS02765 ENOG4105VMP Transcriptional regulator FOC14_RS02780 ENOG41090T1 Membrane FOC14_RS02790 ENOG4108WCX response regulator FOC14_RS02800 ENOG41068WN FOC14_RS02825 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC14_RS02850 ENOG4105CKK Glycosyl transferase, family 2 FOC14_RS02875 ENOG4105CKK Glycosyl transferase, family 2 FOC14_RS02885 ENOG4105C8Y Acetylornithine aminotransferase FOC14_RS02925 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC14_RS02935 ENOG4108TVJ Nitroreductase FOC14_RS02940 ENOG4105FS7 Transcriptional regulator FOC14_RS02975 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC14_RS02985 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC14_RS03015 ENOG4108XET gCN5-related N-acetyltransferase FOC14_RS03095 ENOG410635A Membrane FOC14_RS03100 ENOG4105KNA -acetyltransferase FOC14_RS03105 ENOG4108IQI permease FOC14_RS03115 ENOG4105F1N DNA alkylation repair FOC14_RS03160 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC14_RS03195 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC14_RS03200 ENOG4107258 Transcriptional regulator FOC14_RS03210 ENOG4106N3A copper homeostasis protein cutc FOC14_RS03215 ENOG4108ZRV stage ii sporulation protein p FOC14_RS03220 ENOG4108ZHR arsR family transcriptional regulator FOC14_RS03230 ENOG4105FDT acyl-CoA dehydrogenase FOC14_RS03245 ENOG4105DWD nucleoside recognition domain protein FOC14_RS03275 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC14_RS03335 ENOG4105E2A Dehydrogenase FOC14_RS03350 ENOG4108IJ0 Aspartate ammonia-lyase FOC14_RS03355 ENOG4105HDK L-asparaginase FOC14_RS03360 ENOG4108IMY Transcriptional regulator FOC14_RS03370 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC14_RS03375 ENOG4105CUB amino acid FOC14_RS03385 ENOG4105II7 pyrroline-5-carboxylate reductase FOC14_RS03395 ENOG4105C6K Malic enzyme FOC14_RS03430 ENOG4105CSV Glutaminase FOC14_RS03465 ENOG4105CGH 5'-nucleotidase FOC14_RS03470 ENOG4105CH6 catalase FOC14_RS03480 ENOG4105CHJ isochorismatase hydrolase FOC14_RS03505 ENOG41090MY MarR family Transcriptional regulator FOC14_RS03540 ENOG4108606 TspO/MBR family FOC14_RS03545 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC14_RS03560 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC14_RS03565 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC14_RS03580 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC14_RS03585 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC14_RS03590 ENOG4105DSE periplasmic solute binding protein FOC14_RS03595 ENOG4105CC5 ABC transporter FOC14_RS03600 ENOG4105DIK (ABC) transporter FOC14_RS03630 ENOG4105D6J arsenicaL-resistance protein FOC14_RS03635 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_RS03640 ENOG41085FC arsR family transcriptional regulator FOC14_RS03655 ENOG4105F7F Chaperone FOC14_RS03665 ENOG4105CHR reductase FOC14_RS03670 ENOG4108YXU transcriptional regulator AsnC family FOC14_RS03745 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC14_RS03750 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC14_RS03760 ENOG4105IIP Membrane FOC14_RS03775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_RS03780 ENOG41062D9 Histidine kinase FOC14_RS03805 ENOG4105K6H D-cysteine desulfhydrase FOC14_RS03825 ENOG4105VZ8 Transcriptional regulator FOC14_RS03840 ENOG4108NNI Beta-lactamase domain-containing protein FOC14_RS03845 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC14_RS03855 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC14_RS03860 ENOG4105JQZ Methyltransferase FOC14_RS03875 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC14_RS03880 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC14_RS03895 ENOG4105BZU Histidine kinase FOC14_RS03910 ENOG4108U05 Transcriptional regulator FOC14_RS03925 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC14_RS03930 ENOG4105DJB Major Facilitator Superfamily FOC14_RS03935 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC14_RS03940 ENOG4107QR9 Iron-sulfur cluster binding protein FOC14_RS03950 ENOG4106P55 Transcriptional regulator FOC14_RS03960 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC14_RS03990 ENOG4105TRI Hydrolase FOC14_RS04020 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC14_RS04050 ENOG4107QJQ Mate efflux family protein FOC14_RS04070 ENOG4105EQ0 Major Facilitator superfamily FOC14_RS04075 ENOG4108JGH Tetr family transcriptional regulator FOC14_RS04090 ENOG4105C44 Serine transporter FOC14_RS04095 ENOG4105EJQ L-serine dehydratase FOC14_RS04110 ENOG4108JPW Aminotransferase FOC14_RS04125 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC14_RS04135 ENOG4105DVH amino acid FOC14_RS04150 ENOG4108JQ1 Dehydrogenase FOC14_RS04170 ENOG4108AEY RNA polymerase sigma factor FOC14_RS04185 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC14_RS04190 ENOG410874W AraC family transcriptional regulator FOC14_RS04240 ENOG4108ISG Major Facilitator FOC14_RS04250 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC14_RS04255 ENOG4105CZM Major Facilitator FOC14_RS04275 ENOG4105DA5 (ABC) transporter FOC14_RS04280 ENOG41069JR FOC14_RS04290 ENOG4105RXJ FOC14_RS04295 ENOG4105KPY Small multidrug resistance protein FOC14_RS04300 ENOG4105KBX Transcriptional regulator, TetR family FOC14_RS04310 ENOG4105CRW Short chain fatty acid transporter FOC14_RS04320 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC14_RS04350 ENOG4108JJB ABC transporter FOC14_RS04355 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC14_RS04380 ENOG4108K8S endonuclease I FOC14_RS04395 ENOG41067QW Transcriptional regulator FOC14_RS04405 ENOG4108Z66 YbaK ebsC protein FOC14_RS04410 ENOG4105CUT histidyl-tRNA synthetase FOC14_RS04425 ENOG4105KVH Transcriptional regulator FOC14_RS04430 ENOG4108RCM Nitroreductase FOC14_RS04450 ENOG4108PSK reductase FOC14_RS04460 ENOG4105CJ1 ABC, transporter FOC14_RS04520 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_RS04525 ENOG4105DKQ ROK family FOC14_RS04530 ENOG4106UW1 Major Facilitator superfamily FOC14_RS04535 ENOG4108UW5 maltose o-acetyltransferase FOC14_RS04545 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC14_RS04550 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC14_RS04555 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC14_RS04575 ENOG4105DMQ Methyltransferase FOC14_RS04585 ENOG4105EV4 Multidrug resistance protein mdtH FOC14_RS04615 ENOG4105C37 (CBS) domain FOC14_RS04630 ENOG4105DDN Pentapeptide repeat-containing protein FOC14_RS04635 ENOG4105XDF Protein of unknown function (DUF1272) FOC14_RS04640 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC14_RS04645 ENOG4105CMG Carbohydrate kinase FOC14_RS04650 ENOG4105C6Z Gluconate FOC14_RS04655 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC14_RS04670 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC14_RS04675 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC14_RS04680 ENOG4105CIS alcohol dehydrogenase FOC14_RS04685 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC14_RS04700 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC14_RS04705 ENOG4105D4Y metalloprotease FOC14_RS04725 ENOG4105CV8 reductase FOC14_RS04730 ENOG4105F27 Major Facilitator FOC14_RS04745 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC14_RS04750 ENOG4105C44 Serine transporter FOC14_RS04780 ENOG4105KVH Transcriptional regulator FOC14_RS04785 ENOG4108TZY GntR Family Transcriptional Regulator FOC14_RS04795 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC14_RS04800 ENOG4105KVH Transcriptional regulator FOC14_RS04805 ENOG4105KVH Transcriptional regulator FOC14_RS04840 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC14_RS04850 ENOG4105CHR reductase FOC14_RS04870 ENOG4105KVH Transcriptional regulator FOC14_RS04940 ENOG4105KAF membrAne FOC14_RS04965 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC14_RS04980 ENOG4107YXZ hydrolase, family 25 FOC14_RS05005 ENOG4105ED2 Beta-lactamase FOC14_RS05015 ENOG4105H3G oxidoreductase FOC14_RS05085 ENOG4108TN2 lmbE family FOC14_RS05095 ENOG4107R3E Citrate transporter FOC14_RS05115 ENOG4108MES Periplasmic binding protein FOC14_RS05120 ENOG4105EHG Permease protein FOC14_RS05125 ENOG4105DQ5 transport system permease protein FOC14_RS05130 ENOG4105NX3 Membrane FOC14_RS05135 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC14_RS05155 ENOG4107CUJ Protein of unknown function (DUF2690) FOC14_RS05165 ENOG4107V2S Transcriptional regulator FOC14_RS05185 ENOG4105C98 muts2 protein FOC14_RS05195 ENOG4105E5K Alpha-amylase FOC14_RS05205 ENOG4105DPN Oligoendopeptidase f FOC14_RS05210 ENOG4108A04 Beta-lactamase FOC14_RS05240 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC14_RS05265 ENOG41082BM Transcriptional regulator, arsr family FOC14_RS05270 ENOG4105CIS alcohol dehydrogenase FOC14_RS05295 ENOG4105RHY Pfam:UPF0157 FOC14_RS05305 ENOG4105C09 Bile acid FOC14_RS05310 ENOG4105CQB FAD linked oxidase domain protein FOC14_RS05330 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC14_RS05340 ENOG4105K64 Glycosyl transferase, family 2 FOC14_RS05345 ENOG4105E39 Enoyl-CoA hydratase FOC14_RS05355 ENOG4105KT7 mgtC SapB transporter FOC14_RS05370 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_RS05375 ENOG41073R8 VanW family FOC14_RS05385 ENOG4108R1P FOC14_RS05400 ENOG4105VEQ Cold shock protein FOC14_RS05420 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC14_RS05440 ENOG410904N short-chain dehydrogenase reductase FOC14_RS05450 ENOG4106IQC argininosuccinate lyase FOC14_RS05465 ENOG4108IA2 Sodium pantothenate symporter FOC14_RS05475 ENOG4105C26 Dehydrogenase FOC14_RS05480 ENOG4105CHR reductase FOC14_RS05490 ENOG4105EWU Squalene--hopene cyclase FOC14_RS05500 ENOG4105FR1 rard protein FOC14_RS05505 ENOG410696E Membrane FOC14_RS05520 ENOG4105D1F ATP-binding protein FOC14_RS05530 ENOG4108ZAF Molybdopterin FOC14_RS05535 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC14_RS05540 ENOG4105D06 uba thif-type nad fad binding protein FOC14_RS05545 ENOG4105TMB Formate nitrite transporter FOC14_RS05555 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC14_RS05560 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC14_RS05570 ENOG4108JB9 formate dehydrogenase FOC14_RS05575 ENOG4105E1K spore germination protein FOC14_RS05640 ENOG4108KGH TRANSCRIPTIONal FOC14_RS05650 ENOG4105EMN RNA polymerase sigma factor FOC14_RS05665 ENOG4105CIG ABC transporter FOC14_RS05675 ENOG4105D9R oxidoreductase FOC14_RS05685 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC14_RS05690 ENOG4105K4P CoA-binding domain protein FOC14_RS05695 ENOG4105C0H protease FOC14_RS05700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_RS05710 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC14_RS05715 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC14_RS05720 ENOG4105W8X HesB YadR YfhF-family protein FOC14_RS05750 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC14_RS05755 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC14_RS05765 ENOG4108JJA ABC, transporter FOC14_RS05770 ENOG4108I0Z Aconitate hydratase FOC14_RS05810 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC14_RS05830 ENOG4107F3J Amp-dependent synthetase and ligase FOC14_RS05835 ENOG4107ZYJ bioY protein FOC14_RS05840 ENOG4105CEY Amp-dependent synthetase and ligase FOC14_RS05890 ENOG4107AYK membrAne FOC14_RS05900 ENOG4105BZU Histidine kinase FOC14_RS05905 ENOG4105FBA Phospholipase Carboxylesterase FOC14_RS05910 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC14_RS05915 ENOG4105CK7 Sodium proline symporter FOC14_RS05920 ENOG4105CBC glutamate synthase FOC14_RS05925 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC14_RS05930 ENOG4108VJ1 Transcriptional regulator (CarD family FOC14_RS05935 ENOG4108903 Formimidoylglutamase FOC14_RS05960 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC14_RS06020 ENOG4107QIV Cytochrome c biogenesis protein FOC14_RS06030 ENOG4107RSM transcriptional regulator FOC14_RS06035 ENOG4105VAW lrga family FOC14_RS06040 ENOG41067MG lrgb family FOC14_RS06065 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC14_RS06080 ENOG4105BZ1 (ABC) transporter FOC14_RS06085 ENOG4105BZ1 (ABC) transporter FOC14_RS06105 ENOG4105D7V transposase FOC14_RS06120 ENOG4105D5T phosphonate abc transporter FOC14_RS06140 ENOG4108SVB resolvase FOC14_RS06160 ENOG4105K7K Transcriptional regulator FOC14_RS06190 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC14_RS06195 ENOG4105XSJ toxin secretion phage lysis holin FOC14_RS06380 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC14_RS06480 ENOG4105C5F glutamine synthetase FOC14_RS06485 ENOG4105KV4 Transcriptional regulator FOC14_RS06490 ENOG4105CXI aluminum resistance protein FOC14_RS06500 ENOG4105EN6 Membrane FOC14_RS06510 ENOG4106F1P AAA ATPase, central domain protein FOC14_RS06540 ENOG41069ER domain protein FOC14_RS06545 ENOG4105DM4 PTS System FOC14_RS06550 ENOG4105DE4 1-phosphofructokinase FOC14_RS06555 ENOG4105E98 transcriptional regulator DeoR family FOC14_RS06565 ENOG4108SJC Membrane FOC14_RS06575 ENOG4105C85 amino acid FOC14_RS06590 ENOG4105TMB Formate nitrite transporter FOC14_RS06595 ENOG4105K70 DNA-binding protein FOC14_RS06600 ENOG4105C59 p-type ATPase FOC14_RS06605 ENOG410681U heavy metal transport detoxification protein FOC14_RS06610 ENOG4105VPX protein, conserved in bacteria FOC14_RS06620 ENOG4105NIV Esterase FOC14_RS06625 ENOG4105E0A ABC, transporter FOC14_RS06645 ENOG4105CGK Exodeoxyribonuclease III FOC14_RS06655 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC14_RS06660 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC14_RS06690 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_RS06695 ENOG4105BZU Histidine kinase FOC14_RS06710 ENOG41067MG lrgb family FOC14_RS06725 ENOG4107TTQ Alpha beta hydrolase fold FOC14_RS06730 ENOG4107YEI lmbE family FOC14_RS06755 ENOG4105F0V Cell wall hydrolase FOC14_RS06760 ENOG4107R6R udp-galactopyranose mutase FOC14_RS06765 ENOG4105E0M Sulfatase FOC14_RS06770 ENOG410890F Dynamin family FOC14_RS06780 ENOG4107QHE Choloylglycine hydrolase FOC14_RS06805 ENOG4105DA5 (ABC) transporter FOC14_RS06830 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC14_RS06835 ENOG4105DQU oxidoreductase, subunit beta FOC14_RS06840 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC14_RS06845 ENOG4108IGT Dipeptidase FOC14_RS06850 ENOG4105MCT stage V sporulation protein S FOC14_RS06855 ENOG4105D48 metallophosphoesterase FOC14_RS06880 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC14_RS06895 ENOG4105XZV Protein of unknown function (DUF3243) FOC14_RS06900 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC14_RS06925 ENOG4108JQ9 ABC transporter FOC14_RS06930 ENOG4105DIH basic membrane FOC14_RS06935 ENOG4105FDP GntR family transcriptional regulator FOC14_RS06940 ENOG4107QZI cell division protein FtsK FOC14_RS06950 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC14_RS06960 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC14_RS06970 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC14_RS06975 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC14_RS06980 ENOG4105E35 Dipicolinate synthase subunit A FOC14_RS06990 ENOG4105C1V Peptidase, M16 FOC14_RS07010 ENOG4105DTN riboflavin biosynthesis protein ribF FOC14_RS07015 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC14_RS07025 ENOG4105W7A Protein of unknown function (DUF503) FOC14_RS07035 ENOG4105VHM ribosomal protein FOC14_RS07040 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC14_RS07045 ENOG4105CHV Transcription elongation factor NusA FOC14_RS07055 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC14_RS07065 ENOG4105DZP Membrane-associated zinc metalloprotease FOC14_RS07070 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC14_RS07075 ENOG4105KNE Phosphatidate cytidylyltransferase FOC14_RS07080 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC14_RS07120 ENOG4108HE4 integrase family FOC14_RS07130 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC14_RS07140 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC14_RS07155 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC14_RS07180 ENOG4105VB6 UPF0109 protein FOC14_RS07200 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC14_RS07205 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC14_RS07220 ENOG4105CHR reductase FOC14_RS07225 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC14_RS07240 ENOG4105CB5 ATP-dependent DNA helicase recG FOC14_RS07245 ENOG4105DP4 dak2 domain fusion protein ylov FOC14_RS07250 ENOG4108ZAA Alkaline-shock protein FOC14_RS07265 ENOG4105FJ0 thiamine FOC14_RS07270 ENOG4105DJV ribulose-phosphate 3-epimerase FOC14_RS07275 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC14_RS07280 ENOG4105D9P serine threonine protein kinase FOC14_RS07285 ENOG4108ZF3 Phosphatase FOC14_RS07295 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC14_RS07305 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC14_RS07310 ENOG4105C25 Primosomal protein n' FOC14_RS07315 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC14_RS07335 ENOG4105DSJ YicC domain protein FOC14_RS07345 ENOG4105F23 Fibronectin-binding protein FOC14_RS07350 ENOG4105DC7 peptidase M24 FOC14_RS07405 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC14_RS07430 ENOG4105C34 Pseudouridine synthase FOC14_RS07455 ENOG4105DBK s4 domain protein FOC14_RS07460 ENOG41067XK integral membrane protein FOC14_RS07470 ENOG4105DFA alanine racemase domain protein FOC14_RS07475 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC14_RS07480 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC14_RS07490 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_RS07500 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC14_RS07505 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC14_RS07510 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC14_RS07515 ENOG4105D4A Cell wall formation (By similarity) FOC14_RS07520 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC14_RS07525 ENOG4105CNI cell division protein FtsW FOC14_RS07540 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC14_RS07545 ENOG4105CJN penicillin-binding protein FOC14_RS07550 ENOG4105CJN penicillin-binding protein FOC14_RS07555 ENOG41068DC Essential cell division protein (By similarity) FOC14_RS07595 ENOG4105KNH Nucleic acid-binding protein FOC14_RS07645 ENOG4105XSJ toxin secretion phage lysis holin FOC14_RS07725 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC14_RS07735 ENOG4105CAR Terminase, large subunit FOC14_RS07820 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC14_RS07835 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_RS07880 ENOG4108IMY Transcriptional regulator FOC14_RS07900 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC14_RS07910 ENOG41063PX domain protein FOC14_RS07915 ENOG4105D78 K07001 NTE family protein FOC14_RS07920 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC14_RS07930 ENOG4106H78 methyltransferase FOC14_RS07950 ENOG4107TB6 phosphoglycerate mutase FOC14_RS07965 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC14_RS08015 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC14_RS08020 ENOG4105CNI cell division protein FtsW FOC14_RS08035 ENOG4108IAB Phoh family FOC14_RS08055 ENOG4105QA2 FOC14_RS08060 ENOG4105CI3 gtp-binding protein typa FOC14_RS08070 ENOG4105ECY inositol monophosphatase FOC14_RS08090 ENOG4105CXN decarboxylase FOC14_RS08135 ENOG4105C7S Dehydrogenase FOC14_RS08140 ENOG4105CPP Dehydrogenase, E1 component FOC14_RS08155 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC14_RS08170 ENOG4105CN5 Metallo-Beta-Lactamase FOC14_RS08175 ENOG4107ZYR domain protein FOC14_RS08210 ENOG4108XRC Protein of unknown function (DUF458) FOC14_RS08215 ENOG4107IN1 Protein of unknown function (DUF1797) FOC14_RS08230 ENOG4105EPM Diguanylate phosphodiesterase FOC14_RS08235 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC14_RS08250 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC14_RS08260 ENOG4105UIN FOC14_RS08315 ENOG4108HGU Histidine kinase FOC14_RS08325 ENOG4105CHM Aminotransferase FOC14_RS08330 ENOG4105FKQ transcriptional regulator FOC14_RS08335 ENOG4105EG2 ABC transporter, permease FOC14_RS08345 ENOG4107FKK extracellular solute-binding protein family 1 FOC14_RS08355 ENOG4105CG3 alpha amylase, catalytic region FOC14_RS08400 ENOG4105CHU acetyl-coa acetyltransferase FOC14_RS08440 ENOG4105K7K Transcriptional regulator FOC14_RS08445 ENOG4105DTD Dehydrogenase FOC14_RS08455 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOC14_RS08465 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC14_RS08490 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC14_RS08510 ENOG4106TD9 Diguanylate cyclase FOC14_RS08530 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC14_RS08545 ENOG4105CID antiterminator FOC14_RS08555 ENOG4105FDP GntR family transcriptional regulator FOC14_RS08565 ENOG4105CE4 GlcNAc 6-P deacetylase FOC14_RS08600 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC14_RS08605 ENOG4105PTM secreted protein FOC14_RS08610 ENOG4105J7I hydrolase FOC14_RS08620 ENOG4105G6R Stage v sporulation protein ae FOC14_RS08630 ENOG4105CZ3 stage V sporulation protein ad FOC14_RS08635 ENOG41090VF Stage v sporulation protein ac FOC14_RS08655 ENOG4105C8J )-transporter FOC14_RS08660 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_RS08670 ENOG41082AN stage II sporulation protein FOC14_RS08675 ENOG4105DZ1 carboxypeptidase FOC14_RS08680 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC14_RS08685 ENOG4105DVE abc transporter atp-binding protein FOC14_RS08715 ENOG4105D7N magnesium and cobalt transport protein CorA FOC14_RS08740 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC14_RS08750 ENOG4105I3K Ferric uptake regulator, Fur family FOC14_RS08755 ENOG4105MZ9 stage II sporulation protein m FOC14_RS08775 ENOG4105CPC Aldo Keto reductase FOC14_RS08785 ENOG4105RHY Pfam:UPF0157 FOC14_RS08805 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC14_RS08815 ENOG4105ETE Transcriptional regulator (LacI family FOC14_RS08820 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC14_RS08840 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC14_RS08845 ENOG4108R6K riboflavin synthase, subunit alpha FOC14_RS08865 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC14_RS08870 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC14_RS08875 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC14_RS08880 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC14_RS08890 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC14_RS08900 ENOG4105DFD Na H antiporter FOC14_RS08905 ENOG4105CGH 5'-nucleotidase FOC14_RS08945 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC14_RS08960 ENOG4108IXY short-chain dehydrogenase reductase FOC14_RS08970 ENOG4105II7 pyrroline-5-carboxylate reductase FOC14_RS08975 ENOG4105EJQ L-serine dehydratase FOC14_RS09000 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC14_RS09010 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC14_RS09015 ENOG4105D9U N-acetyltransferase FOC14_RS09030 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC14_RS09035 ENOG4108QEG Membrane FOC14_RS09040 ENOG4105CDA abc transporter atp-binding protein FOC14_RS09045 ENOG4105E5Q amino acid AbC transporter FOC14_RS09050 ENOG4108HW3 (ABC) transporter FOC14_RS09060 ENOG4105G7B Protein of unknown function (DUF2992) FOC14_RS09075 ENOG4105C7S Dehydrogenase FOC14_RS09080 ENOG4105CPP Dehydrogenase, E1 component FOC14_RS09100 ENOG4107RDP Dehydrogenase FOC14_RS09110 ENOG4108JUB Transcriptional regulator FOC14_RS09120 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC14_RS09135 ENOG4107QQR Sporulation FOC14_RS09140 ENOG4105S1Z Stage IV sporulation protein B FOC14_RS09145 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC14_RS09155 ENOG4105DX0 Hemolysin A FOC14_RS09165 ENOG4105CTB Polyprenyl synthetase FOC14_RS09190 ENOG4108ZSR alkaline shock protein FOC14_RS09195 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC14_RS09220 ENOG410644B Stage III sporulation protein af FOC14_RS09230 ENOG4105KQ4 Stage iii sporulation protein ad FOC14_RS09235 ENOG4108CQH stage III sporulation protein AC FOC14_RS09240 ENOG4105KR5 Stage iii sporulation protein FOC14_RS09245 ENOG4105CD2 stage iii sporulation protein aa FOC14_RS09270 ENOG4105DC7 peptidase M24 FOC14_RS09285 ENOG4105CBJ Metal-dependent enzyme FOC14_RS09295 ENOG4107YBY Hydrolase FOC14_RS09315 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC14_RS09320 ENOG4105WZW rhodanese family FOC14_RS09340 ENOG41080TC multidrug resistance protein FOC14_RS09375 ENOG4105CJ1 ABC, transporter FOC14_RS09380 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC14_RS09410 ENOG4105C0D helicase FOC14_RS09530 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC14_RS09535 ENOG4105C3R Methionine synthase FOC14_RS09545 ENOG4105C28 cystathionine FOC14_RS09550 ENOG4105C28 cystathionine FOC14_RS09570 ENOG4105C5X domain protein FOC14_RS09580 ENOG4105DKQ ROK family FOC14_RS09590 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC14_RS09605 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC14_RS09610 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC14_RS09615 ENOG4105E2Z phosphate ABC transporter (Permease FOC14_RS09620 ENOG4105C8U phosphate abc transporter FOC14_RS09625 ENOG4105PWN phosphate abc transporter FOC14_RS09630 ENOG4107RF6 penicillin-binding protein FOC14_RS09640 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC14_RS09665 ENOG4105N80 Ferric uptake regulator, Fur family FOC14_RS09675 ENOG4105FDK ABC transporter FOC14_RS09680 ENOG4108JYZ YitT family FOC14_RS09685 ENOG41069ZM Protein of unknown function (DUF2624) FOC14_RS09710 ENOG4105EGD dinuclear metal center protein, YbgI family FOC14_RS09725 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_RS09730 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC14_RS09755 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC14_RS09760 ENOG4105KG3 cytidine deaminase FOC14_RS09765 ENOG4107YR5 Diacylglycerol kinase FOC14_RS09775 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC14_RS09780 ENOG4105C9A Phoh family FOC14_RS09790 ENOG41068P3 sporulation protein YqfC FOC14_RS09795 ENOG4105KTH gatB Yqey FOC14_RS09805 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC14_RS09810 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC14_RS09830 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC14_RS09840 ENOG4105CSA Coproporphyrinogen iii oxidase FOC14_RS09845 ENOG4105KVH Transcriptional regulator FOC14_RS09870 ENOG4105TQK DNA polymerase iii, delta' subunit FOC14_RS09880 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC14_RS09885 ENOG4108UK2 deaminase FOC14_RS09890 ENOG4105KQC Competence protein FOC14_RS09900 ENOG4105DXX methyltransferase FOC14_RS09910 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC14_RS09920 ENOG410812S Rna-binding protein FOC14_RS09930 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC14_RS09935 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC14_RS09950 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_RS09970 ENOG4108TVJ Nitroreductase FOC14_RS09985 ENOG4105G6Z alkaline phosphatase FOC14_RS09995 ENOG4108MUZ hydrolase FOC14_RS10030 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC14_RS10035 ENOG4105MIR Phenylalanine 4-monooxygenase FOC14_RS10085 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC14_RS10090 ENOG4108V5C ABC transporter FOC14_RS10100 ENOG4108EKI Dehydrogenase FOC14_RS10105 ENOG4105C28 cystathionine FOC14_RS10135 ENOG4107XRG penicillin-binding protein FOC14_RS10150 ENOG4105CFP Peptidase U32 FOC14_RS10155 ENOG4105XYU peptidase (U32 family) FOC14_RS10160 ENOG4108VQJ O-methyltransferase FOC14_RS10165 ENOG4105HHA aminodeoxychorismate lyase FOC14_RS10185 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC14_RS10195 ENOG4105C02 permease FOC14_RS10210 ENOG41060CR FOC14_RS10215 ENOG4105C7H Helicase, RecD TraA family FOC14_RS10225 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC14_RS10230 ENOG4105C3J Cysteine desulfurase FOC14_RS10240 ENOG4105D1H recombination factor protein RarA FOC14_RS10245 ENOG4108VCI transcription factor, rsfa family FOC14_RS10250 ENOG4105CUZ uba thif-type nad fad binding protein FOC14_RS10260 ENOG4105CUT histidyl-tRNA synthetase FOC14_RS10270 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC14_RS10280 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC14_RS10285 ENOG41076HS cation diffusion facilitator family transporter FOC14_RS10290 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC14_RS10300 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC14_RS10305 ENOG4108QG2 Membrane FOC14_RS10315 ENOG4105VIE preprotein translocase, subunit YajC FOC14_RS10330 ENOG41061AI Protein of unknown function (DUF2905) FOC14_RS10345 ENOG4108HUF Transporter FOC14_RS10355 ENOG4108IPJ Membrane FOC14_RS10360 ENOG4108IPJ Membrane FOC14_RS10365 ENOG41082BM Transcriptional regulator, arsr family FOC14_RS10390 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC14_RS10395 ENOG4108IYU L-aspartate oxidase FOC14_RS10410 ENOG4108RPX mosc domain containing protein FOC14_RS10415 ENOG4105CQC Prephenate dehydratase FOC14_RS10445 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC14_RS10460 ENOG4105X36 (ribosomal) protein FOC14_RS10470 ENOG4105C03 ribonuclease FOC14_RS10485 ENOG4107QMS site-determining protein FOC14_RS10500 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC14_RS10505 ENOG4105DFF Rod shape-determining protein mreb FOC14_RS10525 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC14_RS10530 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC14_RS10540 ENOG41068KH stage VI sporulation protein D FOC14_RS10550 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC14_RS10575 ENOG4105K56 Transcriptional regulator FOC14_RS10595 ENOG4108IUQ atp-dependent protease FOC14_RS10620 ENOG4108QCI YvbH-like oligomerisation region FOC14_RS10640 ENOG4105M59 Phosphodiesterase, mj0936 family FOC14_RS10645 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC14_RS10655 ENOG4108XJQ germination protein FOC14_RS10665 ENOG4108PCX Major Facilitator FOC14_RS10675 ENOG4105KBX Transcriptional regulator, TetR family FOC14_RS10690 ENOG4105PFC Transcriptional regulator FOC14_RS10705 ENOG4105DZC cytosine deaminase FOC14_RS10710 ENOG4105DZC cytosine deaminase FOC14_RS10715 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC14_RS10720 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC14_RS10735 ENOG4108JQ7 (ABC) transporter FOC14_RS10745 ENOG4105DY9 regulatoR FOC14_RS10760 ENOG41067S9 phage shock protein C, PspC FOC14_RS10765 ENOG4108JCI Transcriptional regulator FOC14_RS10775 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC14_RS10780 ENOG4108Z40 Transcriptional regulator FOC14_RS10785 ENOG4105RHA ABC transporter, permease FOC14_RS10790 ENOG4108IUX (ABC) transporter FOC14_RS10795 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC14_RS10805 ENOG4105E14 MotA TolQ exbB proton channel FOC14_RS10810 ENOG4108VXD carboxy-peptidase FOC14_RS10820 ENOG4105E33 succinate dehydrogenase FOC14_RS10830 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC14_RS10845 ENOG4105K63 Thioredoxin FOC14_RS10850 ENOG4105C10 Electron transfer flavoprotein FOC14_RS10855 ENOG4105BZJ Electron transfer flavoprotein FOC14_RS10860 ENOG41060WC Enoyl-CoA hydratase FOC14_RS10865 ENOG4107Z3H Transcriptional regulator, TetR family FOC14_RS10870 ENOG4105CEY Amp-dependent synthetase and ligase FOC14_RS10880 ENOG4105J76 Periplasmic binding protein FOC14_RS10885 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC14_RS10925 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_RS10935 ENOG4105DR4 Methyltransferase FOC14_RS10950 ENOG4105KFN sortase, SrtB family FOC14_RS10955 ENOG4105E0A ABC, transporter FOC14_RS10970 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC14_RS10980 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC14_RS10990 ENOG4105FE9 pseudouridine synthase FOC14_RS11000 ENOG4105DCG PHP domain protein FOC14_RS11035 ENOG4105C5S asparaginyl-tRNA synthetase FOC14_RS11040 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC14_RS11050 ENOG4108RWN rrna methyltransferase FOC14_RS11085 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC14_RS11090 ENOG4105CW7 secretion protein, HlyD family FOC14_RS11095 ENOG4108JGH Tetr family transcriptional regulator FOC14_RS11100 ENOG4105CN9 Peptidase m42 family protein FOC14_RS11120 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC14_RS11125 ENOG4105C22 threonyL-tRNA synthetase FOC14_RS11130 ENOG4108TDW sporulation protein YtxC FOC14_RS11150 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC14_RS11160 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC14_RS11165 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC14_RS11175 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC14_RS11180 ENOG4105C2M dna polymerase I FOC14_RS11185 ENOG4105BZU Histidine kinase FOC14_RS11190 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_RS11205 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC14_RS11210 ENOG4105BZN citrate synthase FOC14_RS11220 ENOG4108REF Sporulation integral membrane protein ytvi FOC14_RS11225 ENOG4105FS0 cytoplasmic membrane protein FOC14_RS11250 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC14_RS11255 ENOG4105C6K Malic enzyme FOC14_RS11260 ENOG4105C0B DNA polymerase III (alpha subunit) FOC14_RS11265 ENOG4105VV2 FOC14_RS11275 ENOG4105SFS phosphoesterase RecJ domain protein FOC14_RS11310 ENOG4105DC7 peptidase M24 FOC14_RS11345 ENOG4105Z7P Acetyltransferase (GNAT) family FOC14_RS11350 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC14_RS11360 ENOG4105VZ8 Transcriptional regulator FOC14_RS11380 ENOG4107YZX Universal stress protein FOC14_RS11420 ENOG4108JYZ YitT family FOC14_RS11440 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC14_RS11450 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC14_RS11455 ENOG4105KBJ sporulation protein ytfj FOC14_RS11470 ENOG4105EFZ amidohydrolase FOC14_RS11480 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC14_RS11505 ENOG4106KR7 LysR family Transcriptional regulator FOC14_RS11525 ENOG4105C28 cystathionine FOC14_RS11545 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC14_RS11555 ENOG4105EMN RNA polymerase sigma factor FOC14_RS11575 ENOG4105F1V Acetoin utilization protein FOC14_RS11580 ENOG4105W87 Cbs domain FOC14_RS11585 ENOG4105DGU Histone deacetylase FOC14_RS11595 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_RS11605 ENOG4107SNB ankyrin repeat protein YahD FOC14_RS11610 ENOG4105EP9 oxidoreductase FOC14_RS11640 ENOG4105ETE Transcriptional regulator (LacI family FOC14_RS11660 ENOG4105C88 aminopeptidase FOC14_RS11705 ENOG4108VDD TRNA binding domain protein FOC14_RS11735 ENOG4105C8F Beta-lactamase domain protein FOC14_RS11750 ENOG4108V15 phosphotransferase enzyme family FOC14_RS11755 ENOG4108IUM Glycogen debranching enzyme FOC14_RS11770 ENOG4105YW5 deoR family transcriptional regulator FOC14_RS11785 ENOG4105CBX hi0933 family FOC14_RS11820 ENOG4108VJ1 Transcriptional regulator (CarD family FOC14_RS11825 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC14_RS11830 ENOG4105CSC Glucose uptake protein FOC14_RS11845 ENOG4108ZAF Molybdopterin FOC14_RS11850 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC14_RS11855 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC14_RS11865 ENOG4105D06 uba thif-type nad fad binding protein FOC14_RS11890 ENOG41085GJ domain protein FOC14_RS11900 ENOG4105DWV Homoserine O-trans-acetylase FOC14_RS11910 ENOG4108B31 Spore germination protein FOC14_RS11940 ENOG410605W Major Facilitator FOC14_RS11945 ENOG4107S91 Sodium hydrogen exchanger FOC14_RS11950 ENOG4105NCW Trka-c domain protein FOC14_RS11965 ENOG4105C19 ABC transporter FOC14_RS11985 ENOG4105N5T Radical SAM Protein FOC14_RS11995 ENOG4105DA5 (ABC) transporter FOC14_RS12025 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC14_RS12030 ENOG4108Z0R Transferase FOC14_RS12035 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC14_RS12040 ENOG4105BZF Glycosyl transferase (Group 1 FOC14_RS12050 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC14_RS12100 ENOG4105EGD dinuclear metal center protein, YbgI family FOC14_RS12105 ENOG4105BZU Histidine kinase FOC14_RS12110 ENOG4105BZU Histidine kinase FOC14_RS12115 ENOG4107S9D Alpha beta hydrolase FOC14_RS12135 ENOG4105D2X ABC transporter substrate-binding protein FOC14_RS12145 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC14_RS12200 ENOG4108V2W Carbonate dehydratase FOC14_RS12205 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC14_RS12210 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC14_RS12255 ENOG41087YS Phage shock protein A FOC14_RS12290 ENOG4105BZU Histidine kinase FOC14_RS12295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_RS12320 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC14_RS12325 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC14_RS12360 ENOG4107ZTW SNARE associated Golgi FOC14_RS12375 ENOG4105C19 ABC transporter FOC14_RS12380 ENOG41086D8 Transcriptional regulator FOC14_RS12420 ENOG4105C6Z Gluconate FOC14_RS12425 ENOG4105FDP GntR family transcriptional regulator FOC14_RS12445 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC14_RS12475 ENOG4105DTQ mandelate racemase muconate lactonizing FOC14_RS12485 ENOG4108IPT Naphthoate synthase FOC14_RS12490 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC14_RS12495 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC14_RS12500 ENOG4105E4F Isochorismate synthase FOC14_RS12505 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC14_RS12515 ENOG4105VEQ Cold shock protein FOC14_RS12535 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC14_RS12545 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC14_RS12565 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC14_RS12660 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC14_RS12695 ENOG4105KT7 mgtC SapB transporter FOC14_RS12700 ENOG4107PBV potassium channel FOC14_RS12710 ENOG4107QYV phosphohexose isomerase FOC14_RS12715 ENOG4105WG9 Conserved Protein FOC14_RS12725 ENOG4105CHM Aminotransferase FOC14_RS12730 ENOG4108ZB6 transcriptional regulator AsnC family FOC14_RS12735 ENOG4105C5I Dehydrogenase FOC14_RS12740 ENOG4108MUZ hydrolase FOC14_RS12750 ENOG4105C87 Aminotransferase class I and II FOC14_RS12760 ENOG4105Y38 Kinase-associated protein B FOC14_RS12770 ENOG4107R3E Citrate transporter FOC14_RS12785 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOC14_RS12790 ENOG4105KA0 thioesterase Superfamily protein FOC14_RS12810 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC14_RS12830 ENOG41069ER domain protein FOC14_RS12845 ENOG4105CEP NADH dehydrogenase FOC14_RS12875 ENOG4105EWC Purine nucleoside phosphorylase FOC14_RS12895 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC14_RS12920 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC14_RS12925 ENOG4105C4B ABC transporter, permease FOC14_RS12930 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC14_RS12975 ENOG41083MR nifu domain-containing protein FOC14_RS12990 ENOG4108W5N phosphatidylglycerophosphatase a FOC14_RS13000 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC14_RS13005 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC14_RS13020 ENOG4105CBT Fructose-1,6-bisphosphatase FOC14_RS13035 ENOG4105MMD transcriptional regulator FOC14_RS13040 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC14_RS13045 ENOG4107TXC Transcriptional regulator FOC14_RS13050 ENOG41090T1 Membrane FOC14_RS13075 ENOG4105FAA peptidase M23 FOC14_RS13085 ENOG4105KZD Domain of unknown function (DUF1805) FOC14_RS13090 ENOG4107R8B 5'-nucleotidase FOC14_RS13105 ENOG4105DIW FeS assembly protein SUFB FOC14_RS13110 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC14_RS13115 ENOG4105C9B Cysteine desulfurase FOC14_RS13120 ENOG4105JRK feS assembly protein SufD FOC14_RS13125 ENOG4105C3K feS assembly ATPase SufC FOC14_RS13130 ENOG4105D01 (LipO)protein FOC14_RS13135 ENOG4105D01 (LipO)protein FOC14_RS13140 ENOG4108UMI ABC transporter, permease FOC14_RS13175 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC14_RS13220 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC14_RS13245 ENOG4108W8B Beta-lactamase domain protein FOC14_RS13250 ENOG4105C1G acyl-Coa dehydrogenase FOC14_RS13255 ENOG4105CHU acetyl-coa acetyltransferase FOC14_RS13270 ENOG4105DZ1 carboxypeptidase FOC14_RS13290 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC14_RS13305 ENOG4108SUT Major Facilitator Superfamily FOC14_RS13310 ENOG4107R7I amino acid FOC14_RS13320 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC14_RS13330 ENOG4107AYK membrAne FOC14_RS13365 ENOG4107ZTW SNARE associated Golgi FOC14_RS13375 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC14_RS13380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_RS13385 ENOG4105BZU Histidine kinase FOC14_RS13395 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC14_RS13410 ENOG4105VG1 fes assembly suf system protein FOC14_RS13415 ENOG4105D4Y metalloprotease FOC14_RS13435 ENOG4107S91 Sodium hydrogen exchanger FOC14_RS13440 ENOG4105NCW Trka-c domain protein FOC14_RS13450 ENOG4108RMU ferritin dps family protein FOC14_RS13465 ENOG4108URH decarboxylase FOC14_RS13485 ENOG4105D9N nucleoside FOC14_RS13490 ENOG4105D9N nucleoside FOC14_RS13505 ENOG4108RYK Nad-dependent epimerase dehydratase FOC14_RS13520 ENOG4105CV8 reductase FOC14_RS13525 ENOG4105F27 Major Facilitator FOC14_RS13530 ENOG4105KVH Transcriptional regulator FOC14_RS13545 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC14_RS13550 ENOG4105D4A Cell wall formation (By similarity) FOC14_RS13560 ENOG4105C8Q Methyl-accepting chemotaxis FOC14_RS13570 ENOG4105WMR Protein CrcB homolog FOC14_RS13575 ENOG4105WMR Protein CrcB homolog FOC14_RS13590 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC14_RS13595 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOC14_RS13610 ENOG4108IPW abc transporter atp-binding protein FOC14_RS13615 ENOG4105CM4 permease protein FOC14_RS13645 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC14_RS13655 ENOG4105XZU Preprotein translocase, subunit SecG FOC14_RS13660 ENOG41067MG lrgb family FOC14_RS13755 ENOG4105EFC phage portal protein HK97 family FOC14_RS13780 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC14_RS13790 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC14_RS13795 ENOG4105CP7 Triose-phosphate isomerase FOC14_RS13820 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_RS13840 ENOG41090VF Stage v sporulation protein ac FOC14_RS13845 ENOG4105CZ3 stage V sporulation protein ad FOC14_RS13860 ENOG4105H67 Protein of unknown function (DUF421) FOC14_RS13865 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC14_RS13870 ENOG4105KRI phosphocarrier protein (HPr FOC14_RS13880 ENOG4105CHW UPF0052 protein FOC14_RS13890 ENOG4108Z4K mutator MutT protein FOC14_RS13900 ENOG4105C3M thioredoxin reductase FOC14_RS13910 ENOG4108S4C acetyltransferase FOC14_RS13930 ENOG41086DT Membrane protein of unknown function FOC14_RS13940 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC14_RS13945 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC14_RS13950 ENOG4105D7V transposase FOC14_RS13965 ENOG4107TXC Transcriptional regulator FOC14_RS13990 ENOG4105HMI Membrane FOC14_RS13995 ENOG4105DUM transcriptional regulator, lysR family FOC14_RS14005 ENOG4108WS4 fmn reductase FOC14_RS14020 ENOG4105BZ1 (ABC) transporter FOC14_RS14030 ENOG4105CN1 protease FOC14_RS14035 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC14_RS14040 ENOG4105CAK Cell division ATP-binding protein ftsE FOC14_RS14060 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC14_RS14065 ENOG4105MS2 ribosomal subunit Interface protein FOC14_RS14070 ENOG4105VEQ Cold shock protein FOC14_RS14075 ENOG41081UC Inherit from COG: Competence protein FOC14_RS14090 ENOG4105KVH Transcriptional regulator FOC14_RS14100 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC14_RS14105 ENOG4108KGH TRANSCRIPTIONal FOC14_RS14110 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC14_RS14115 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC14_RS14120 ENOG4105ESV Glycosyl transferase, family 4 FOC14_RS14130 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC14_RS14145 ENOG410901P UPF0249 protein FOC14_RS14150 ENOG4105F8D glycoside hydrolase family 4 FOC14_RS14155 ENOG4105VCP PTS System FOC14_RS14160 ENOG4105CK1 PTS System FOC14_RS14170 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC14_RS14175 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC14_RS14180 ENOG4105VCP PTS System FOC14_RS14190 ENOG4105VZJ PTS System FOC14_RS14205 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_RS14210 ENOG4105ECB domain protein FOC14_RS14215 ENOG4107RSM transcriptional regulator FOC14_RS14255 ENOG4105DAA L-lactate FOC14_RS14265 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC14_RS14275 ENOG4105E0M Sulfatase FOC14_RS14305 ENOG4105C94 Transporter FOC14_RS14310 ENOG41069ER domain protein FOC14_RS14335 ENOG4105KBK Zinc finger, swim domain protein FOC14_RS14340 ENOG4105C0D helicase FOC14_RS14370 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_RS14380 ENOG4107RBB ABC transporter, permease FOC14_RS14385 ENOG4105C19 ABC transporter FOC14_RS14405 ENOG4105CXY transporter FOC14_RS14420 ENOG4105BZU Histidine kinase FOC14_RS14425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_RS14430 ENOG4105CMR udp-glucose 4-epimerase FOC14_RS14445 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC14_RS14450 ENOG4105EY8 ABC transporter FOC14_RS14505 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC14_RS14520 ENOG4105FRN stage II sporulation protein FOC14_RS14555 ENOG4106778 Protein of unknown function (DUF1146) FOC14_RS14560 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC14_RS14565 ENOG4105C8S subunit m FOC14_RS14570 ENOG4105D65 subunit l FOC14_RS14595 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC14_RS14600 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC14_RS14610 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC14_RS14615 ENOG4105BZU Histidine kinase FOC14_RS14665 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC14_RS14670 ENOG41062M3 atp synthase FOC14_RS14700 ENOG4108YZG isomerase FOC14_RS14715 ENOG4108VGI doxx family FOC14_RS14720 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC14_RS14735 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC14_RS14745 ENOG4108ZXQ stage ii sporulation protein r FOC14_RS14750 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC14_RS14755 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC14_RS14770 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC14_RS14775 ENOG4105CBT Fructose-1,6-bisphosphatase FOC14_RS14780 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC14_RS14815 ENOG4105C1G acyl-Coa dehydrogenase FOC14_RS14820 ENOG4105C1G acyl-Coa dehydrogenase FOC14_RS14825 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC14_RS14835 ENOG4105DF6 Fe-S oxidoreductase FOC14_RS14850 ENOG4105BZU Histidine kinase FOC14_RS14875 ENOG4105BZU Histidine kinase FOC14_RS14880 ENOG4105KCT ABC transporter FOC14_RS14885 ENOG4108M15 ABC transporter FOC14_RS14890 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC14_RS14900 ENOG4105IIU Aminopeptidase FOC14_RS14920 ENOG4105EMN RNA polymerase sigma factor FOC14_RS14930 ENOG410684U Domain of unknown function (DUF1934) FOC14_RS14950 ENOG4105CYW agmatinase FOC14_RS14960 ENOG4105DXB Major Facilitator superfamily FOC14_RS14965 ENOG4107SWG transcriptional regulator MERR family FOC14_RS14970 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC14_RS14975 ENOG4105BZ4 penicillin-binding protein FOC14_RS14980 ENOG4108XFG YwhD family FOC14_RS14985 ENOG4108Z4T Peptidase M50 FOC14_RS14990 ENOG41069HH 4-oxalocrotonate tautomerase FOC14_RS14995 ENOG4105DCI Phosphohydrolase FOC14_RS15000 ENOG4108MES Periplasmic binding protein FOC14_RS15005 ENOG4105E0A ABC, transporter FOC14_RS15010 ENOG4105EHG Permease protein FOC14_RS15025 ENOG4108VCI transcription factor, rsfa family FOC14_RS15040 ENOG4108IJ2 phosphate acetyltransferase FOC14_RS15055 ENOG4108VKI Cell wall hydrolase FOC14_RS15085 ENOG410667J hydrolase FOC14_RS15090 ENOG4105VCH membrane FOC14_RS15100 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC14_RS15105 ENOG4105CJ1 ABC, transporter FOC14_RS15110 ENOG41090WU lipolytic protein G-D-S-L family FOC14_RS15125 ENOG4105D6E homoserine dehydrogenase FOC14_RS15150 ENOG4108Y4K DNA-binding transcriptional activator FOC14_RS15160 ENOG4105WH1 Two component transcriptional regulator luxr family FOC14_RS15170 ENOG4105DWF phosphomethylpyrimidine kinase FOC14_RS15175 ENOG4105BZU Histidine kinase FOC14_RS15180 ENOG4105VCD cytoplasmic protein FOC14_RS15185 ENOG4105D22 carbon starvation protein FOC14_RS15190 ENOG4105DY9 regulatoR FOC14_RS15195 ENOG41079KZ Major Facilitator Superfamily FOC14_RS15215 ENOG4105EN6 Membrane FOC14_RS15220 ENOG4106YBV Methyl-accepting chemotaxis FOC14_RS15230 ENOG4108S4H thioesterase Superfamily protein FOC14_RS15240 ENOG4105JEU Glycosyl transferase, family 2 FOC14_RS15245 ENOG4105C5H ABC transporter FOC14_RS15265 ENOG4105CKK Glycosyl transferase, family 2 FOC14_RS15270 ENOG41067SE Tetr family transcriptional regulator FOC14_RS15280 ENOG4105E0X reductase FOC14_RS15285 ENOG4106F5Q Membrane FOC14_RS15300 ENOG4105DY9 regulatoR FOC14_RS15305 ENOG4108HRK Histidine kinase FOC14_RS15310 ENOG4107RGD Major Facilitator superfamily FOC14_RS15325 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC14_RS15335 ENOG4105IW1 AmiS UreI transporter FOC14_RS15345 ENOG4105CMR udp-glucose 4-epimerase FOC14_RS15350 ENOG4108UT2 hemolysin iii FOC14_RS15360 ENOG4105C1J atp-dependent rna helicase FOC14_RS15375 ENOG4105DPN Oligoendopeptidase f FOC14_RS15395 ENOG4105C0H protease FOC14_RS15400 ENOG4105Q2H domain protein FOC14_RS15415 ENOG4105BZU Histidine kinase FOC14_RS15420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_RS15450 ENOG4105CDU Replicative dna helicase FOC14_RS15460 ENOG4105BZR domain protein FOC14_RS15465 ENOG4108XMW Membrane FOC14_RS15475 ENOG4108UUM single-stranded DNA-binding protein FOC14_RS15485 ENOG4105C3G gtp-binding protein FOC14_RS15490 ENOG4105VDK protein, conserved in bacteria FOC14_RS15495 ENOG4105D8X mechanosensitive ion channel FOC14_RS15500 ENOG4108ZDA Sporulation protein YyaC FOC14_RS15505 ENOG4105FA0 parb-like partition protein FOC14_RS15510 ENOG4107QJE Chromosome Partitioning Protein FOC14_RS15530 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC14_RS15540 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC14_RS15560 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC14_RS15565 ENOG410848D S4 domain protein YaaA FOC14_RS15580 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC14_RS15615 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC14_RS15650 ENOG4105ZMH deoxynucleoside kinase FOC14_RS15660 ENOG4105GTG Isochorismatase FOC14_RS15665 ENOG4108Z6B deaminase FOC14_RS15675 ENOG4105C6E dna polymerase iii FOC14_RS15695 ENOG41067KS pro-sigma K processing FOC14_RS15730 ENOG4105CXN decarboxylase FOC14_RS15740 ENOG4105FA2 dna polymerase iii FOC14_RS15745 ENOG4105MA4 psp1 domain protein FOC14_RS15755 ENOG41060K3 Methyltransferase FOC14_RS15765 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC14_RS15770 ENOG4105KRN Transcriptional regulator, abrb family FOC14_RS15780 ENOG4105F8V Hydrolase, tatD family FOC14_RS15785 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC14_RS15795 ENOG4105XFA sporulation peptidase YabG FOC14_RS15800 ENOG4105W42 Veg protein FOC14_RS15815 ENOG4105DFT pur operon repressor FOC14_RS15820 ENOG4105KME endoribonuclease L-psp FOC14_RS15835 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC14_RS15840 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC14_RS15850 ENOG4108JA2 transcriptioN-repair coupling factor FOC14_RS15855 ENOG4108M14 stage v sporulation protein t FOC14_RS15865 ENOG4108IY2 MazG family FOC14_RS15870 ENOG41082I2 s4 domain protein FOC14_RS15875 ENOG4105VYY sporulation protein yabp FOC14_RS15890 ENOG41060GV RNA binding s1 domain protein FOC14_RS15910 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC14_RS15915 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC14_RS15920 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC14_RS15935 ENOG4105C6T cysteine synthase FOC14_RS15940 ENOG4105CRQ synthase (Component I) FOC14_RS15945 ENOG4105DDQ anthranilate synthase FOC14_RS15950 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC14_RS15955 ENOG4105EEI dihydropteroate synthase FOC14_RS15960 ENOG4105KRF dihydroneopterin aldolase FOC14_RS15965 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC14_RS15975 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC14_RS16005 ENOG4108Z0C Uvrb UvrC protein FOC14_RS16020 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC14_RS16030 ENOG4105CTP PilT protein domain protein FOC14_RS16050 ENOG4105D7W serine acetyltransferase FOC14_RS16065 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC14_RS16070 ENOG4105M0M Tetracycline resistance protein FOC14_RS16075 ENOG4105QIV RNA polymerase FOC14_RS16090 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC14_RS16115 ENOG4107Y49 methyltransferase FOC14_RS16125 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC14_RS16130 ENOG4105XPM ribosomal protein FOC14_RS16235 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC14_RS16260 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC14_RS16270 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC14_RS16280 ENOG41067V7 50S ribosomal protein L36 FOC14_RS16310 ENOG4108JJB ABC transporter FOC14_RS16315 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC14_RS16320 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC14_RS16345 ENOG4105D1F ATP-binding protein FOC14_RS16360 ENOG4108NMV polysaccharide deacetylase FOC14_RS16440 ENOG4105C8B TIGR00159 family FOC14_RS16445 ENOG4107U5W ybbr family FOC14_RS16460 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC14_RS16465 ENOG4108VQT Alpha beta hydrolase fold protein FOC14_RS16485 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC14_RS16490 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC14_RS16525 ENOG4108UMI ABC transporter, permease FOC14_RS16530 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC14_RS16535 ENOG4105D01 (LipO)protein FOC14_RS16540 ENOG4105EE1 crotonyl-CoA reductase FOC14_RS16550 ENOG4105IQ5 FAD linked oxidase domain protein FOC14_RS16565 ENOG4105C2C drug resistance transporter, Bcr CflA FOC14_RS16580 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC14_RS16585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC14_RS16590 ENOG4105C3U ABC transporter FOC14_RS16595 ENOG4108JQ7 (ABC) transporter FOC14_RS16625 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC14_RS16630 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC14_RS16640 ENOG4105II7 pyrroline-5-carboxylate reductase FOC14_RS16645 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC14_RS16655 ENOG4105E0C molybdate abc transporter FOC14_RS16665 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC14_RS16675 ENOG4105EGI Transcriptional regulator FOC14_RS16695 ENOG4105F6E Acyl-transferase FOC14_RS16715 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC14_RS16725 ENOG4108RE7 deoxyribonuclease FOC14_RS16730 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC14_RS16750 ENOG4105C5H ABC transporter FOC14_RS16765 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC14_RS16775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC14_RS16780 ENOG4105C3U ABC transporter FOC14_RS16785 ENOG4108JQ7 (ABC) transporter FOC14_RS16805 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC14_RS16810 ENOG4105ERH Fumarylacetoacetate hydrolase FOC14_RS16820 ENOG4108SC4 )-transporter FOC14_RS16830 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC14_RS16845 ENOG4107ZXI Rhomboid family FOC14_RS16855 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC14_RS16860 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC14_RS16870 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC14_RS16970 ENOG4105K8N protein family UPF0079, ATPase FOC14_RS16975 ENOG41072GX Peptidase M22 Glycoprotease FOC14_RS16980 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC14_RS16985 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC14_RS16990 ENOG4105C5H ABC transporter FOC14_RS17005 ENOG4108TYN CAAX amino terminal protease family protein FOC14_RS17025 ENOG4105C7N Xanthine uracil vitamin C permease FOC14_RS17035 ENOG4105BZU Histidine kinase FOC14_RS17065 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC14_RS17105 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC14_RS17125 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_RS17145 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC14_RS17150 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC14_RS17155 ENOG4105C83 adenylosuccinate lyase FOC14_RS17165 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC14_RS17190 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC14_RS17200 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC14_RS17225 ENOG4105C4R Atp-dependent dna helicase FOC14_RS17250 ENOG4108W2Y isochorismatase FOC14_RS17255 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC14_RS17260 ENOG4108UMI ABC transporter, permease FOC14_RS17265 ENOG4105D01 (LipO)protein FOC14_RS17285 ENOG410834F Transcriptional regulator FOC14_RS17310 ENOG4105CBD Diacylglycerol kinase FOC14_RS17315 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC14_RS17320 ENOG4108JPW Aminotransferase FOC14_RS17330 ENOG4105C26 Dehydrogenase FOC14_RS17335 ENOG4105KPY Small multidrug resistance protein FOC14_RS17355 ENOG4105D9N nucleoside FOC14_RS17360 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC14_RS17375 ENOG4108W15 Protein of unknown function (DUF1456) FOC14_RS17390 ENOG4105DTQ mandelate racemase muconate lactonizing FOC14_RS17400 ENOG4105DFD Na H antiporter FOC14_RS17420 ENOG4105D3R alkyl hydroperoxide reductase FOC14_RS17425 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOC14_RS17435 ENOG4107W7X Aldolase FOC14_RS17440 ENOG4105EHG Permease protein FOC14_RS17445 ENOG4105DQ5 transport system permease protein FOC14_RS17450 ENOG4108V5C ABC transporter FOC14_RS17470 ENOG4106UIA FOC14_RS17475 ENOG4106UIA FOC14_RS17500 ENOG4105BZU Histidine kinase FOC14_RS17520 ENOG410756H nucleotidyltransferase FOC14_RS17525 ENOG4105D2S major facilitator superfamily FOC14_RS17540 ENOG4105E5Q amino acid AbC transporter FOC14_RS17545 ENOG4105EAB amino acid AbC transporter FOC14_RS17555 ENOG4105C8Q Methyl-accepting chemotaxis FOC14_RS17560 ENOG4105C8Q Methyl-accepting chemotaxis FOC14_RS17570 ENOG4105CI1 PTS System FOC14_RS17600 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC14_RS17615 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC14_RS17630 ENOG4105C5H ABC transporter FOC14_RS17655 ENOG41062JF Transcriptional regulator FOC14_RS17675 ENOG4105DEU major facilitator superfamily FOC14_RS17690 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FOC14_RS17705 ENOG4108N0M stress protein FOC14_RS17710 ENOG4106FN3 tellurium resistance protein FOC14_RS17715 ENOG4106FN3 tellurium resistance protein FOC14_RS17720 ENOG4107TS3 membrane protein, TerC FOC14_RS17725 ENOG4108TTB tellurium resistance protein FOC14_RS17745 ENOG4105KJF protein tyrosine phosphatase FOC14_RS17755 ENOG4107U9T Pfam:Ribonuclease_BN FOC14_RS17760 ENOG4105C59 p-type ATPase FOC14_RS17765 ENOG4108IPJ Membrane FOC14_RS17785 ENOG4107ZTW SNARE associated Golgi FOC14_RS17800 ENOG410606W general stress protein FOC14_RS17805 ENOG4105UPD Calcium Proton FOC14_RS17845 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC14_RS17850 ENOG4105VTR Integrase FOC14_RS17855 ENOG4108IMY Transcriptional regulator FOC14_RS18115 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC14_RS18125 ENOG4108JUB Transcriptional regulator FOC14_RS18135 ENOG4108IQI permease FOC14_RS18160 ENOG4105CSV Glutaminase FOC14_RS18170 ENOG4108A04 Beta-lactamase FOC14_RS18185 ENOG4105CKK Glycosyl transferase, family 2 FOC14_RS18195 ENOG4107QQG Dehydrogenase FOC14_RS18200 ENOG4105C3I Nad-dependent epimerase dehydratase FOC14_RS18220 ENOG4105F1A Pyruvate formate-lyase FOC14_RS18240 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC14_RS18245 ENOG4105ECP epimerase FOC14_RS18275 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC14_RS18280 ENOG4105CEN a g-specific adenine glycosylase FOC14_RS18285 ENOG4106BXE FOC14_RS18305 ENOG4105BZ1 (ABC) transporter FOC14_RS18310 ENOG4107NBY Membrane FOC14_RS18315 ENOG4105CBC glutamate synthase FOC14_RS18325 ENOG4108IUW ABC transporter FOC14_RS18345 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC14_RS18350 ENOG4105G5W regulator Fur family FOC14_RS18465 ENOG4108JQC penicillin-binding protein 1A FOC14_RS18470 ENOG4107ZQN disulfide bond FOC14_RS18480 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC14_RS18490 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC14_RS18495 ENOG4105BZU Histidine kinase FOC14_RS18500 ENOG4105CYN Serine protein kinase FOC14_RS18520 ENOG4105C94 Transporter FOC14_RS18535 ENOG4105DZ6 Band 7 protein FOC14_RS18545 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC14_RS18555 ENOG4105D4T Citrate transporter FOC14_RS18575 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC14_RS18580 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC14_RS18585 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC14_RS18590 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC14_RS18595 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC14_RS18600 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC14_RS18605 ENOG4108STX response regulator FOC14_RS18610 ENOG4105US7 Histidine kinase FOC14_RS18635 ENOG4108MRH transcriptional regulatory protein FOC14_RS18645 ENOG4105C6K Malic enzyme FOC14_RS18655 ENOG4108UZ3 Transporter FOC14_RS18660 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC14_RS18670 ENOG4105BZU Histidine kinase FOC14_RS18675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_RS18680 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC14_RS18685 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC14_RS18690 ENOG4108JB9 formate dehydrogenase FOC14_RS18710 ENOG4105CUB amino acid FOC14_RS18720 ENOG4105C59 p-type ATPase FOC14_RS18725 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC14_RS18760 ENOG41073R8 VanW family FOC14_RS18765 ENOG4108KGH TRANSCRIPTIONal FOC14_RS18770 ENOG4105D9N nucleoside FOC14_RS18775 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC14_RS18780 ENOG4105C37 (CBS) domain FOC14_RS18785 ENOG4108IJ0 Aspartate ammonia-lyase FOC14_RS18790 ENOG4105DAA L-lactate FOC14_RS18805 ENOG4105DUX Transporter FOC14_RS18810 ENOG4108MES Periplasmic binding protein FOC14_RS18815 ENOG4105DQ5 transport system permease protein FOC14_RS18820 ENOG4108IHU transport system permease protein FOC14_RS18825 ENOG4105E0A ABC, transporter FOC14_RS18830 ENOG4105DMQ Methyltransferase FOC14_RS18840 ENOG4105EXW epimerase dehydratase FOC14_RS18850 ENOG4107T89 von Willebrand factor, type A FOC14_RS18855 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC14_RS18860 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC14_RS18875 ENOG4105BZU Histidine kinase FOC14_RS18880 ENOG4105D5Q Arginine ornithine antiporter FOC14_RS18885 ENOG4107414 GntR family transcriptional regulator FOC14_RS18890 ENOG4105C5Y PTS System FOC14_RS18895 ENOG4105CG3 alpha amylase, catalytic region FOC14_RS18910 ENOG4105E1K spore germination protein FOC14_RS18920 ENOG4105CRN Aminoglycoside phosphotransferase FOC14_RS18925 ENOG4105BZG amino acid carrier protein FOC14_RS18930 ENOG4105CDA abc transporter atp-binding protein FOC14_RS18935 ENOG4105CT1 (ABC) transporter FOC14_RS18940 ENOG4105EAD ABC transporter FOC14_RS18945 ENOG4105DRP amino acid AbC transporter FOC14_RS18950 ENOG4108IQI permease FOC14_RS18975 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC14_RS18980 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC14_RS18985 ENOG4105BZU Histidine kinase FOC14_RS19000 ENOG4105CHH sulfate transporter FOC14_RS19005 ENOG41068KF Universal stress protein FOC14_RS19015 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC14_RS19025 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC14_RS19030 ENOG4108JQ7 (ABC) transporter FOC14_RS19040 ENOG4105CXY transporter FOC14_RS19045 ENOG41067TZ transcriptional regulator, MarR family FOC14_RS19055 ENOG4105ETE Transcriptional regulator (LacI family FOC14_RS19060 ENOG4108RVA ribokinase FOC14_RS19075 ENOG4105CNN ABC, transporter FOC14_RS19080 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC14_RS19085 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC14_RS19145 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC14_RS19150 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC14_RS19155 ENOG41069ER domain protein FOC14_RS19160 ENOG4105VZ8 Transcriptional regulator FOC14_RS19165 ENOG4107D63 FOC14_RS19175 ENOG4105DUX Transporter FOC14_RS19195 ENOG4105C85 amino acid FOC14_RS19200 ENOG4105C7N Xanthine uracil vitamin C permease FOC14_RS19240 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC14_RS19245 ENOG4105E2S oxidase) subunit II FOC14_RS19250 ENOG4108IQI permease FOC14_RS19265 ENOG4106CAD Protein of unknown function (DUF3311) FOC14_RS19270 ENOG4105E1V na solute symporter FOC14_RS19285 ENOG4108NHD germination protein FOC14_RS19290 ENOG4105CE1 Ferrous iron transport protein b FOC14_RS19295 ENOG4105CE1 Ferrous iron transport protein b FOC14_RS19300 ENOG4105CE1 Ferrous iron transport protein b FOC14_RS19305 ENOG4105CVA phosphate FOC14_RS19310 ENOG4105C8U phosphate abc transporter FOC14_RS19315 ENOG4105E2Z phosphate ABC transporter (Permease FOC14_RS19440 ENOG41080XQ Signal transduction protein with cbs domains FOC14_RS19460 ENOG4105ETU transcriptional activator (TenA FOC14_RS19470 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC14_RS19480 ENOG4108VEU Thiamine monophosphate synthase FOC14_RS19485 ENOG41080HI glycine oxidase FOC14_RS19500 ENOG4105D06 uba thif-type nad fad binding protein FOC14_RS19505 ENOG4105DWF phosphomethylpyrimidine kinase FOC14_RS19555 ENOG4108INS Transcriptional regulator FOC14_RS19570 ENOG4105C7N Xanthine uracil vitamin C permease FOC14_RS19600 ENOG4105C5Y PTS System FOC14_RS19655 ENOG4107Y03 Nitroreductase FOC14_RS19660 ENOG4105ED1 spovr family FOC14_RS19685 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC14_RS19690 ENOG4105XTG Pfam:DUF156 FOC14_RS19695 ENOG4105VFE sira family FOC14_RS19700 ENOG4107TPS domain protein FOC14_RS19705 ENOG4105VFE sira family FOC14_RS19710 ENOG41085GJ domain protein FOC14_RS19720 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC14_RS19725 ENOG41087NI Sulfite exporter TauE/SafE FOC14_RS19735 ENOG4108KGH TRANSCRIPTIONal FOC14_RS19760 ENOG4105EMD TRANSCRIPTIONal FOC14_RS19765 ENOG4105VCP PTS System FOC14_RS19770 ENOG4105VZJ PTS System FOC14_RS19790 ENOG41069ER domain protein FOC14_RS19795 ENOG4107RBB ABC transporter, permease FOC14_RS19800 ENOG4105C19 ABC transporter FOC14_RS19830 ENOG4105WEF catalase FOC14_RS19865 ENOG4107T5V SNARE associated Golgi FOC14_RS19895 ENOG4105CUB amino acid FOC14_RS19900 ENOG4107RWR Sodium hydrogen exchanger FOC14_RS19910 ENOG4106KNT transcriptional regulator FOC14_RS19945 ENOG4108PCN EamA-like transporter family FOC14_RS19950 ENOG4108YXU transcriptional regulator AsnC family FOC14_RS19960 ENOG4105KPY Small multidrug resistance protein FOC14_RS19965 ENOG4105KPY Small multidrug resistance protein FOC14_RS19990 ENOG4105NF4 modulator of drug activity FOC14_RS19995 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC14_RS20000 ENOG4105E5W Transporter FOC14_RS20010 ENOG4107RKG DJ-1/PfpI family FOC14_RS20015 ENOG4105CH6 catalase FOC14_RS20025 ENOG4105D5Q Arginine ornithine antiporter FOC14_RS20030 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC14_RS20040 ENOG4105C26 Dehydrogenase FOC14_RS20045 ENOG4105BZ1 (ABC) transporter FOC14_RS20060 ENOG4105DRP amino acid AbC transporter FOC14_RS20065 ENOG4105CDA abc transporter atp-binding protein FOC14_RS20080 ENOG410839P FOC14_RS20115 ENOG4107FQX Alpha-acetolactate decarboxylase FOC14_RS20145 ENOG4105D4P Coproporphyrinogen iii oxidase FOC14_RS20160 ENOG4105CHH sulfate transporter FOC14_RS20200 ENOG4106AKK s-layer domain-containing protein FOC14_RS20210 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC14_RS20215 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC14_RS20230 ENOG4105CGU Enoyl-CoA hydratase FOC14_RS20250 ENOG4105DER m42 family FOC14_RS20270 ENOG4105CTU Proline racemase FOC14_RS20310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC14_RS20320 ENOG4108JQ7 (ABC) transporter FOC14_RS20325 ENOG4105PKS Excinuclease abc c subunit domain protein FOC14_RS20355 ENOG4105CSH Transporter FOC14_RS20365 ENOG4108MRH transcriptional regulatory protein FOC14_RS20415 ENOG4105CDU Replicative dna helicase FOC14_RS20445 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC14_RS20490 ENOG4107P5I polyketide synthase FOC14_RS20495 ENOG4108IG5 Transcriptional regulator FOC14_RS20515 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC14_RS20535 ENOG4105CMT Dihydroxyacetone kinase FOC14_RS20545 ENOG4105CMT Dihydroxyacetone kinase FOC14_RS20550 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC14_RS20555 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC14_RS20585 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC14_RS20650 ENOG4105WN5 stage II sporulation protein FOC14_RS20660 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_RS20670 ENOG4108MJI response regulator FOC14_RS20675 ENOG4105BZU Histidine kinase FOC14_RS20680 ENOG4105BZU Histidine kinase FOC14_RS20700 ENOG4105K8R UPF0145 protein FOC14_RS20730 ENOG4107VRP DNA repair exonuclease FOC14_RS20740 ENOG4105D7V transposase FOC14_RS20755 ENOG4108IND Tetr family transcriptional regulator FOC14_RS20760 ENOG4105EQ0 Major Facilitator superfamily FOC14_RS20780 ENOG4108MUZ hydrolase FOC14_RS20800 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC14_RS20815 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC14_RS20825 ENOG4105EMN RNA polymerase sigma factor FOC14_RS20850 ENOG4105C57 major facilitator superfamily FOC14_RS20855 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC14_RS20865 ENOG4105EEM helicase FOC14_RS20870 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC14_RS20895 ENOG4105K59 histidine triad (HIT) protein FOC14_RS20925 ENOG410905X membrane-flanked domain protein FOC14_RS20970 ENOG410905X membrane-flanked domain protein FOC14_RS20975 ENOG4105CKV Membrane FOC14_RS20980 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC14_RS20985 ENOG4105BZ4 penicillin-binding protein FOC14_RS20990 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC14_RS21000 ENOG4105C1Q protoporphyrinogen oxidase FOC14_RS21025 ENOG4105NA0 Transcriptional regulator FOC14_RS21040 ENOG4105ECB domain protein FOC14_RS21070 ENOG4106AXD FOC14_RS21075 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC14_RS21080 ENOG4105DF9 Lipoate-protein, ligase FOC14_RS21090 ENOG4105CEY Amp-dependent synthetase and ligase FOC14_RS21120 ENOG4105CNA YD repeat protein FOC14_RS21155 ENOG4107TVP HD domain protein FOC14_RS21165 ENOG4108AEY RNA polymerase sigma factor FOC14_RS21170 ENOG41086D8 Transcriptional regulator FOC14_RS21185 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_RS21210 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC14_RS21215 ENOG4105C8Q Methyl-accepting chemotaxis FOC14_RS21235 ENOG4105ZU5 s-layer protein FOC14_RS21240 ENOG4107QP3 malate synthase g FOC14_RS21255 ENOG4105VEQ Cold shock protein FOC14_RS21270 ENOG4105XVF Competence transcription factor FOC14_RS21285 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC14_RS21290 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC14_RS21335 ENOG4105ERH Fumarylacetoacetate hydrolase FOC14_RS21360 ENOG4105CAQ asparagine synthetase FOC14_RS21365 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC14_RS21370 ENOG4105CH6 catalase FOC14_RS21395 ENOG4105QNR S1 RNA binding domain protein FOC14_RS21405 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC14_RS21415 ENOG4107AYK membrAne FOC14_RS21420 ENOG41073B9 FOC14_RS21430 ENOG4108KP7 hydrolase FOC14_RS21440 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC14_RS21465 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC14_RS21470 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC14_RS21485 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC14_RS21500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC14_RS21505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC14_RS21515 ENOG4108JQ7 (ABC) transporter FOC14_RS21520 ENOG4105UQX Mate efflux family protein FOC14_RS21540 ENOG4108ZCF integral membrane protein FOC14_RS21550 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC14_RS21560 ENOG4105DPN Oligoendopeptidase f FOC14_RS21570 ENOG4108Z18 K06886 hemoglobin FOC14_RS21575 ENOG4105MIX Adenylate cyclase FOC14_RS21590 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC14_RS21595 ENOG4105EMS pseudouridine synthase FOC14_RS21615 ENOG4105K64 Glycosyl transferase, family 2 FOC14_RS21635 ENOG4107TVC Glycosyl transferase, family 2 FOC14_RS21655 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC14_RS21660 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC14_RS21670 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC14_RS21720 ENOG4108WVJ 2'-5' rna ligase FOC14_RS21745 ENOG4105CK7 Sodium proline symporter FOC14_RS21755 ENOG4105DDQ anthranilate synthase FOC14_RS21850 ENOG4105C7S Dehydrogenase FOC14_RS21860 ENOG4105VZ8 Transcriptional regulator FOC14_RS21920 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC14_RS21930 ENOG4105DZ1 carboxypeptidase FOC14_RS21935 ENOG4105VFR signal peptidase FOC14_RS21970 ENOG4105C26 Dehydrogenase FOC14_RS21975 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC14_RS21980 ENOG4105F38 ABC transporter, permease FOC14_RS21985 ENOG4105D38 putrescine abc transporter FOC14_RS21990 ENOG4107RUE extracellular solute-binding protein family 1 FOC14_RS22000 ENOG4105EYF MMPL domain protein FOC14_RS22010 ENOG4108YBP pseudouridine synthase FOC14_RS22020 ENOG4105K4I Scp-like extracellular FOC14_RS22025 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC14_RS22030 ENOG4105CQB FAD linked oxidase domain protein FOC14_RS22045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_RS22050 ENOG4105BZU Histidine kinase FOC14_RS22055 ENOG4105JXH GntR family transcriptional regulator FOC14_RS22075 ENOG4106A3R peptidase FOC14_RS22085 ENOG4108QTI )-transporter FOC14_RS22090 ENOG4107TS3 membrane protein, TerC FOC14_RS22095 ENOG4105CZN Potassium uptake protein FOC14_RS22100 ENOG410681C small acid-soluble spore protein FOC14_RS22105 ENOG4108Z7G MaoC domain protein dehydratase FOC14_RS22125 ENOG4105CHR reductase FOC14_RS22135 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC14_RS22150 ENOG4105C4Y ABC transporter FOC14_RS22165 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC14_RS22180 ENOG4105E98 transcriptional regulator DeoR family FOC14_RS22200 ENOG4105PXI polysaccharide deacetylase FOC14_RS22210 ENOG4105BZU Histidine kinase FOC14_RS22215 ENOG41090MY MarR family Transcriptional regulator FOC14_RS22225 ENOG4106DF1 FOC14_RS22230 ENOG4105BZU Histidine kinase FOC14_RS22240 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC14_RS22245 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC14_RS22280 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC14_RS22300 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC14_RS22305 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC14_RS22310 ENOG4105CZV ABC transporter FOC14_RS22320 ENOG4105CJ1 ABC, transporter FOC14_RS22360 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC14_RS22365 ENOG4105EA8 2-Nitropropane dioxygenase FOC14_RS22370 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC14_RS22380 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC14_RS22400 ENOG4105NQC Flavodoxin FOC14_RS22425 ENOG4107QMU Mate efflux family protein FOC14_RS22430 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC14_RS22460 ENOG4105CZN Potassium uptake protein FOC14_RS22465 ENOG41063Y9 FOC14_RS22470 ENOG4105KBJ sporulation protein ytfj FOC14_RS22495 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC14_RS22500 ENOG4105C7K acetolactate synthase FOC14_RS22505 ENOG4108ZP8 Acetolactate synthase small subunit FOC14_RS22510 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC14_RS22520 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC14_RS22545 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC14_RS22580 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC14_RS22595 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC14_RS22600 ENOG4105E0M Sulfatase FOC14_RS22610 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC14_RS22630 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC14_RS22635 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC14_RS22645 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC14_RS22650 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC14_RS22655 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC14_RS22660 ENOG4105C8J )-transporter FOC14_RS22680 ENOG4105DFD Na H antiporter FOC14_RS22700 ENOG4105ENE Histidine kinase FOC14_RS22705 ENOG4105WH1 Two component transcriptional regulator luxr family FOC14_RS22725 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC14_RS22750 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC14_RS22770 ENOG4105CJ3 phosphate transporter FOC14_RS22775 ENOG4107GRR phosphate transport regulator FOC14_RS22780 ENOG4105BZ4 penicillin-binding protein FOC14_RS22800 ENOG4105I3N Conserved Protein FOC14_RS22815 ENOG4105BZU Histidine kinase FOC14_RS22850 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC14_RS22855 ENOG4105DZ1 carboxypeptidase FOC14_RS22860 ENOG4108JIC nucleoside recognition domain protein FOC14_RS22870 ENOG4105FE9 pseudouridine synthase FOC14_RS22880 ENOG4107TWT Cytochrome c biogenesis protein FOC14_RS22885 ENOG4105CRE cytochrome C FOC14_RS22890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_RS22895 ENOG4105BZU Histidine kinase FOC14_RS22900 ENOG4108WBT adenosyltransferase FOC14_RS22915 ENOG4108SAX Membrane FOC14_RS22925 ENOG4105T7X FOC14_RS22930 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC14_RS22935 ENOG4105I7S Abortive infection protein FOC14_RS22950 ENOG4107X2D transcriptional regulator, merr family FOC14_RS22955 ENOG4108S6Z Negative regulator of genetic competence FOC14_RS22980 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC14_RS22985 ENOG4105HDK L-asparaginase FOC14_RS23020 ENOG4105S2F FOC14_RS23025 ENOG41065D1 FOC14_RS23055 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC14_RS23070 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC14_RS23080 ENOG4105EAH synthase FOC14_RS23100 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC14_RS23105 ENOG41068YB TPR repeat-containing protein FOC14_RS23120 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC14_RS23125 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC14_RS23130 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC14_RS23160 ENOG4108JYZ YitT family FOC14_RS23165 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC14_RS23180 ENOG4105FJR Lmbe family FOC14_RS23185 ENOG4105CPK Glycosyl transferase (Group 1 FOC14_RS23220 ENOG4105DVT helicase FOC14_RS23225 ENOG4105YAC FOC14_RS23245 ENOG4105CSM endonuclease III FOC14_RS23255 ENOG4105BZ4 penicillin-binding protein FOC14_RS23310 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC14_RS23320 ENOG4105DVT helicase FOC14_RS23325 ENOG4105CTD carboxy-peptidase FOC14_RS23340 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC14_RS23355 ENOG4105C2W permease FOC14_RS23360 ENOG4105DHF Membrane FOC14_RS23365 ENOG410890F Dynamin family FOC14_RS23375 ENOG4108W0I acetyltransferase FOC14_RS23385 ENOG4105KHC sulfurtransferase FOC14_RS23485 ENOG4108SZE gCN5-related N-acetyltransferase FOC14_RS23505 ENOG41081VK Ribonuclease FOC14_RS23570 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC14_RS23580 ENOG4107RWR Sodium hydrogen exchanger FOC14_RS23590 ENOG4108Z5V transcriptional regulator, merr family FOC14_RS23600 ENOG4105H67 Protein of unknown function (DUF421) FOC14_RS23605 ENOG41080C8 DUF218 domain FOC14_RS23660 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC14_RS23670 ENOG4107R0U MotA TolQ exbB proton channel FOC14_RS23675 ENOG4105ER2 Ompa motb domain protein FOC14_RS23680 ENOG4107YTP response regulator receiver protein FOC14_RS23690 ENOG4105DD5 Flagellar motor switch protein FOC14_RS23705 ENOG4105BZU Histidine kinase FOC14_RS23725 ENOG4105E1Q flagellar hook-associated protein FOC14_RS23750 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC14_RS23755 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC14_RS23760 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOC14_RS23770 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC14_RS23805 ENOG4105BZE flagellar hook protein, FlgE FOC14_RS23830 ENOG4105K64 Glycosyl transferase, family 2 FOC14_RS23865 ENOG4105I03 Flagellin FOC14_RS23870 ENOG4105E4C Lytic transglycosylase catalytic FOC14_RS23885 ENOG4105DD5 Flagellar motor switch protein FOC14_RS23895 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC14_RS23900 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC14_RS23910 ENOG4105D00 flagellar biosynthetic protein flhB FOC14_RS23915 ENOG4105D7B Flagellar biosynthesis protein flha FOC14_RS23925 ENOG4105KTQ flagellar basal-body rod protein FOC14_RS23930 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC14_RS23955 ENOG4108RZE Tetr family transcriptional regulator FOC14_RS23975 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC14_RS24000 ENOG4105DUM transcriptional regulator, lysR family FOC14_RS24005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC14_RS24010 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC14_RS24015 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC14_RS24020 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC14_RS24060 ENOG4105CVJ phosphoglycerate mutase FOC14_RS24090 ENOG4105CAQ asparagine synthetase FOC14_RS24110 ENOG4105PGM cation diffusion facilitator family transporter FOC14_RS24120 ENOG4105DRR Transcriptional regulator, GntR family FOC14_RS24125 ENOG4108UZ3 Transporter FOC14_RS24130 ENOG4105CKI cobalamin synthesis protein FOC14_RS24135 ENOG4108PJD permease FOC14_RS24150 ENOG4105DFD Na H antiporter FOC14_RS24155 ENOG4105C9Q fumarate hydratase class II FOC14_RS24180 ENOG4105EC3 peptidase S51, dipeptidase E FOC14_RS24200 ENOG4107QIV Cytochrome c biogenesis protein FOC14_RS24230 ENOG4106BRA Membrane FOC14_RS24265 ENOG4105CJ1 ABC, transporter FOC14_RS24285 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC14_RS24295 ENOG4108IJ0 Aspartate ammonia-lyase FOC14_RS24300 ENOG4105C6K Malic enzyme FOC14_RS24360 ENOG4105FVX FOC14_RS24400 ENOG4105CSR polyphosphate kinase 2 FOC14_RS24430 ENOG4105EU0 Major facilitator Superfamily FOC14_RS24435 ENOG4105C6T cysteine synthase FOC14_RS24455 ENOG4105C8J )-transporter FOC14_RS24465 ENOG4105X5K response regulator receiver protein FOC14_RS24470 ENOG4105H67 Protein of unknown function (DUF421) FOC14_RS24485 ENOG4106KE4 Dehydrogenase FOC14_RS24500 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC14_RS24505 ENOG4105CHR reductase FOC14_RS24510 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC14_RS24515 ENOG4105C7K acetolactate synthase FOC14_RS24520 ENOG4108ZP8 Acetolactate synthase small subunit FOC14_RS24525 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC14_RS24535 ENOG4105C7B Threonine dehydratase FOC14_RS24560 ENOG4105C6X Major Facilitator FOC14_RS24565 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC14_RS24575 ENOG4105DY9 regulatoR FOC14_RS24580 ENOG4105CYC Transferase FOC14_RS24600 ENOG4105F6J Alpha beta hydrolase fold FOC14_RS24635 ENOG41068WN FOC14_RS24655 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC14_RS24660 ENOG4105C72 UPF0176 protein FOC14_RS24670 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC14_RS24700 ENOG4107RHR regulatoR FOC14_RS24710 ENOG4105D9N nucleoside FOC14_RS24715 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC14_RS24750 ENOG4107RAQ aminopeptidase FOC14_RS24755 ENOG4107STQ Multicopper oxidase FOC14_RS24800 ENOG4108T5E Copper resistance protein FOC14_RS24805 ENOG4105KTB nuclear export factor GLE1 FOC14_RS24815 ENOG4107RT3 EamA-like transporter family FOC14_RS24820 ENOG4105GZI Transcriptional regulator FOC14_RS24825 ENOG4108Z40 Transcriptional regulator FOC14_RS24830 ENOG4107ZXU DSBA oxidoreductase FOC14_RS24835 ENOG4108TVJ Nitroreductase FOC14_RS24840 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC14_RS24845 ENOG4106F5Q Membrane FOC14_RS24850 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC14_RS24860 ENOG4105CKI cobalamin synthesis protein FOC14_RS24880 ENOG4108Z7G MaoC domain protein dehydratase FOC14_RS24885 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC14_RS24895 ENOG4105C0Z ABC transporter FOC14_RS24900 ENOG4108IV0 ABC, transporter FOC14_RS24905 ENOG4105C32 Amino acid ABC transporter (Permease) FOC14_RS24915 ENOG4105SKE transcriptional Regulator LysR family FOC14_RS24935 ENOG4105YGB Transcriptional regulator FOC14_RS24945 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC14_RS24950 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC14_RS24955 ENOG4108JJ9 ABC, transporter FOC14_RS24960 ENOG4108JJ8 (ABC) transporter FOC14_RS25010 ENOG4105EFI regulatoR FOC14_RS25015 ENOG4105BZU Histidine kinase FOC14_RS25035 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC14_RS25040 ENOG4108ZJ4 polysaccharide deacetylase FOC14_RS25060 ENOG4105D6E homoserine dehydrogenase FOC14_RS25085 ENOG4108KGH TRANSCRIPTIONal FOC14_RS25095 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_RS25100 ENOG4105BZU Histidine kinase FOC14_RS25105 ENOG4107VMI polysaccharide deacetylase FOC14_RS25115 ENOG4105KT7 mgtC SapB transporter FOC14_RS25120 ENOG4105VRR gCN5-related N-acetyltransferase FOC14_RS25130 ENOG4105DUU IucA IucC family protein FOC14_RS25135 ENOG4105CEY Amp-dependent synthetase and ligase FOC14_RS25150 ENOG4108WBH protein TIM barrel FOC14_RS25155 ENOG4105YWU small acid-soluble spore protein FOC14_RS25165 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC14_RS25215 ENOG4105KRN Transcriptional regulator, abrb family FOC14_RS25225 ENOG4105YVS arsR family transcriptional regulator FOC14_RS25230 ENOG4107SET aldo keto reductase FOC14_RS25235 ENOG4107XZQ multidrug resistance protein FOC14_RS25260 ENOG4105C8Q Methyl-accepting chemotaxis FOC14_RS25275 ENOG4108K88 Membrane FOC14_RS25280 ENOG4108WPJ Ferritin-like domain FOC14_RS25295 ENOG4105DEN Luciferase family FOC14_RS25315 ENOG4107QM2 Aldo Keto reductase FOC14_RS25320 ENOG4105CKI cobalamin synthesis protein FOC14_RS25375 ENOG4105DSE periplasmic solute binding protein FOC14_RS25380 ENOG4105K4T epimerase FOC14_RS25390 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC14_RS25415 ENOG4105CVJ phosphoglycerate mutase FOC14_RS25435 ENOG4107T5V SNARE associated Golgi FOC14_RS25450 ENOG4108PJD permease FOC14_RS25460 ENOG4108S4H thioesterase Superfamily protein FOC14_RS25470 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC14_RS25490 ENOG4105SXS Protein of unknown function (DUF456) FOC14_RS25495 ENOG4105C37 (CBS) domain FOC14_RS25515 ENOG4108Z7R Chaperone CsaA FOC14_RS25535 ENOG4108ZRV stage ii sporulation protein p FOC14_RS25545 ENOG4108VXD carboxy-peptidase FOC14_RS25555 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC14_RS25580 ENOG4108X4Q Hydrolase FOC14_RS25590 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC14_RS25595 ENOG4107RBS Methyltransferase FOC14_RS25610 ENOG41087PP glycosyltransferase MGT family FOC14_RS25615 ENOG4108JYZ YitT family FOC14_RS25620 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC14_RS25645 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC14_RS25695 ENOG4105KBJ sporulation protein ytfj FOC14_RS25720 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC14_RS25745 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_RS25755 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC14_RS25760 ENOG4105EMN RNA polymerase sigma factor FOC14_RS25785 ENOG4108V06 Glutathione peroxidase FOC14_RS25800 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC14_RS25820 ENOG4108IUE nitrate reductase beta subunit FOC14_RS25825 ENOG4105R3A Nitrate reductase FOC14_RS25850 ENOG4107V6Q Cyclic nucleotide-binding domain FOC14_RS25855 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC14_RS25860 ENOG4105D06 uba thif-type nad fad binding protein FOC14_RS25865 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC14_RS25870 ENOG4108ZAF Molybdopterin FOC14_RS25895 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC14_RS25900 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC14_RS25905 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC14_RS25910 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC14_RS25915 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC14_RS25920 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC14_RS25955 ENOG4105MCT stage V sporulation protein S FOC14_RS25970 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC14_RS25990 ENOG4105C5H ABC transporter FOC14_RS26005 ENOG4108UUM single-stranded DNA-binding protein FOC14_RS26035 ENOG4107YX5 Pfam:DUF548 FOC14_RS26040 ENOG4105C75 arginyL-tRNA synthetase FOC14_RS26065 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC14_RS26085 ENOG4105C5S asparaginyl-tRNA synthetase FOC14_RS26105 ENOG4105EC2 ftsk spoIIIe FOC14_RS26175 ENOG4105BZW Glycerate kinase FOC14_RS26180 ENOG4107QPK )-transporter FOC14_RS26185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_RS26190 ENOG41062D9 Histidine kinase FOC14_RS26205 ENOG4105C8J )-transporter FOC14_RS26225 ENOG4107XGZ Hydrolase FOC14_RS26230 ENOG4105CY2 Citrate transporter FOC14_RS26235 ENOG4105C0A alcohol dehydrogenase FOC14_RS26250 ENOG4105KD7 acetyltransferase FOC14_RS26280 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC14_RS26300 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC14_RS26315 ENOG4107RVG penicillin-binding protein FOC14_RS26320 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC14_RS26325 ENOG4105E9Q Acyl-transferase FOC14_RS26330 ENOG4108UT2 hemolysin iii FOC14_RS26340 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC14_RS26350 ENOG4108RCR degv family FOC14_RS26355 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC14_RS26360 ENOG4108KF3 Electron transport protein SCO1 SenC FOC14_RS26365 ENOG4107Y70 Heat shock protein FOC14_RS26370 ENOG4105CAQ asparagine synthetase FOC14_RS26385 ENOG4108MES Periplasmic binding protein FOC14_RS26390 ENOG4105F0I Aminotransferase FOC14_RS26425 ENOG4105D8X mechanosensitive ion channel FOC14_RS26430 ENOG4105BZU Histidine kinase FOC14_RS26435 ENOG4105WH1 Two component transcriptional regulator luxr family FOC14_RS26470 ENOG4105CMG Carbohydrate kinase FOC14_RS26475 ENOG4105CMG Carbohydrate kinase FOC14_RS26505 ENOG4108IJ8 ABC transporter FOC14_RS26510 ENOG4105E90 ABC transporter FOC14_RS26545 ENOG4105C37 (CBS) domain FOC14_RS26570 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC14_RS26585 ENOG4107S4Y M20 DapE family protein YgeY FOC14_RS26590 ENOG4108TSC N-acetyltransferase FOC14_RS26595 ENOG4108JUB Transcriptional regulator FOC14_RS26600 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC14_RS26640 ENOG4108N23 SpoOM-related protein FOC14_RS26645 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC14_RS26655 ENOG4105SZ6 Thioredoxin FOC14_RS26670 ENOG4108IBT Inherit from COG: transposase FOC14_RS26775 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC14_RS26815 ENOG4105BZ4 penicillin-binding protein FOC14_RS26820 ENOG4105CZM Major Facilitator FOC14_RS26825 ENOG4105W8X HesB YadR YfhF-family protein FOC14_RS26835 ENOG4105DXD 2-methylcitrate dehydratase FOC14_RS26840 ENOG4105CR4 methylisocitrate lyase FOC14_RS26845 ENOG4105C1G acyl-Coa dehydrogenase FOC14_RS26850 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC14_RS26860 ENOG4105N14 lysine exporter protein LysE YggA FOC14_RS26865 ENOG4105E39 Enoyl-CoA hydratase FOC14_RS26880 ENOG4107RFY SbcCD D subunit FOC14_RS26885 ENOG4105EYH Exonuclease FOC14_RS26905 ENOG4105FCD Major Facilitator FOC14_RS26910 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC14_RS26915 ENOG4105E4F Isochorismate synthase FOC14_RS26920 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC14_RS26925 ENOG4105WQI isochorismatase FOC14_RS26930 ENOG4105CEY Amp-dependent synthetase and ligase FOC14_RS26935 ENOG4105WQT MbtH domain protein FOC14_RS26940 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC14_RS26955 ENOG4105K70 DNA-binding protein FOC14_RS26975 ENOG4105BZG amino acid carrier protein FOC14_RS26995 ENOG4105FE9 pseudouridine synthase FOC14_RS27000 ENOG4105C22 threonyL-tRNA synthetase FOC14_RS27015 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC14_RS27040 ENOG4108D32 Methyltransferase FOC14_RS27070 ENOG41081I9 integral membrane protein