locus-tag	class	description
HYU01_RS00010	COG0592	DNA-directed DNA polymerase activity
HYU01_RS00015	COG2501	S4 domain
HYU01_RS00025	COG0187	DNA topoisomerase II activity
HYU01_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYU01_RS00065	COG0517	IMP dehydrogenase activity
HYU01_RS00065	COG0516	GMP reductase activity
HYU01_RS00070	COG1686	Belongs to the peptidase S11 family
HYU01_RS00100	COG1428	Deoxynucleoside kinase
HYU01_RS00105	COG1428	Deoxynucleoside kinase
HYU01_RS00110	COG1335	isochorismatase
HYU01_RS00120	COG0590	tRNA wobble adenosine to inosine editing
HYU01_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYU01_RS00180	COG1982	Orn Lys Arg decarboxylase major
HYU01_RS00190	COG0470	DNA polymerase III
HYU01_RS00195	COG1774	PSP1 C-terminal conserved region
HYU01_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HYU01_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYU01_RS00220	COG2002	toxin-antitoxin pair type II binding
HYU01_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYU01_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYU01_RS00230	COG0084	hydrolase, TatD family'
HYU01_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HYU01_RS00250	COG4466	Protein conserved in bacteria
HYU01_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYU01_RS00270	COG0251	oxidation-reduction process
HYU01_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYU01_RS00305	COG2002	toxin-antitoxin pair type II binding
HYU01_RS00310	COG2244	polysaccharide biosynthetic process
HYU01_RS00315	COG3956	TIGRFAM MazG family protein
HYU01_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HYU01_RS00340	COG1098	S1 RNA binding domain
HYU01_RS00355	COG2208	phosphoserine phosphatase activity
HYU01_RS00360	COG0037	tRNA processing
HYU01_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYU01_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYU01_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYU01_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HYU01_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
HYU01_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYU01_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HYU01_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HYU01_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HYU01_RS00420	COG1396	sequence-specific DNA binding
HYU01_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYU01_RS00455	COG3880	PFAM UvrB UvrC protein
HYU01_RS00465	COG0542	response to heat
HYU01_RS00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYU01_RS00480	COG4956	integral membrane protein (PIN domain superfamily)
HYU01_RS00500	COG1045	serine acetyltransferase
HYU01_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYU01_RS00520	COG3688	RNA-binding protein containing a PIN domain
HYU01_RS00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYU01_RS00540	COG0250	Participates in transcription elongation, termination and antitermination
HYU01_RS00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYU01_RS00565	COG2813	Specifically methylates the guanine in position
HYU01_RS00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYU01_RS00580	COG1358	cellular component organization or biogenesis
HYU01_RS00650	COG0255	Belongs to the universal ribosomal protein uL29 family
HYU01_RS00710	COG0201	protein transport
HYU01_RS00720	COG0024	Methionine aminopeptidase
HYU01_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYU01_RS00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HYU01_RS00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYU01_RS00795	COG0489	protein tyrosine kinase activity
HYU01_RS00805	COG2194	sulfuric ester hydrolase activity
HYU01_RS00810	COG0726	polysaccharide deacetylase
HYU01_RS00895	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HYU01_RS00900	COG4856	YbbR-like protein
HYU01_RS00915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYU01_RS00920	COG0596	Alpha beta hydrolase
HYU01_RS00940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HYU01_RS00945	COG0823	Involved in the tonB-independent uptake of proteins
HYU01_RS00945	COG1506	peptidase
HYU01_RS00945	COG4946	Tricorn protease homolog
HYU01_RS00975	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS00980	COG2011	ABC-type metal ion transport system permease component
HYU01_RS00985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYU01_RS00990	COG1464	Belongs to the NlpA lipoprotein family
HYU01_RS00995	COG0604	alcohol dehydrogenase
HYU01_RS01010	COG2271	Major facilitator Superfamily
HYU01_RS01020	COG2814	Major facilitator Superfamily
HYU01_RS01035	COG0601	transmembrane transport
HYU01_RS01040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYU01_RS01045	COG0444	Belongs to the ABC transporter superfamily
HYU01_RS01050	COG4608	Belongs to the ABC transporter superfamily
HYU01_RS01055	COG4166	transmembrane transport
HYU01_RS01065	COG2207	Transcriptional regulator
HYU01_RS01080	COG4166	transmembrane transport
HYU01_RS01085	COG4166	transmembrane transport
HYU01_RS01090	COG0656	L-ascorbic acid biosynthetic process
HYU01_RS01095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYU01_RS01115	COG4149	molybdate abc transporter
HYU01_RS01120	COG0725	ABC transporter, periplasmic molybdate-binding protein
HYU01_RS01125	COG1910	domain protein
HYU01_RS01140	COG0583	DNA-binding transcription factor activity
HYU01_RS01145	COG0697	spore germination
HYU01_RS01155	COG0204	Acyl-transferase
HYU01_RS01165	COG1609	Transcriptional regulator
HYU01_RS01175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYU01_RS01190	COG0084	hydrolase, TatD family'
HYU01_RS01195	COG5298	Protein conserved in bacteria
HYU01_RS01220	COG0488	(ABC) transporter
HYU01_RS01235	COG0747	negative chemotaxis
HYU01_RS01240	COG0601	transmembrane transport
HYU01_RS01245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYU01_RS01250	COG0444	Belongs to the ABC transporter superfamily
HYU01_RS01255	COG4608	Belongs to the ABC transporter superfamily
HYU01_RS01280	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HYU01_RS01285	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYU01_RS01295	COG2814	Major facilitator Superfamily
HYU01_RS01310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYU01_RS01320	COG4294	response to UV
HYU01_RS01325	COG0705	Rhomboid family
HYU01_RS01325	COG0457	Tetratricopeptide repeat
HYU01_RS01335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HYU01_RS01340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYU01_RS01345	COG0864	Transcriptional regulator
HYU01_RS01350	COG2337	Toxic component of a toxin-antitoxin (TA) module
HYU01_RS01355	COG2183	response to ionizing radiation
HYU01_RS01450	COG0802	atpase or kinase
HYU01_RS01455	COG1214	PFAM Peptidase M22, glycoprotease
HYU01_RS01460	COG0456	acetyltransferase
HYU01_RS01470	COG0488	(ABC) transporter
HYU01_RS01485	COG1266	CAAX protease self-immunity
HYU01_RS01505	COG2252	PERMEase
HYU01_RS01515	COG5002	protein histidine kinase activity
HYU01_RS01535	COG1968	undecaprenyl-diphosphatase activity
HYU01_RS01550	COG2205	protein histidine kinase activity
HYU01_RS01555	COG0745	RESPONSE REGULATOR receiver
HYU01_RS01575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYU01_RS01580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYU01_RS01585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYU01_RS01595	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYU01_RS01610	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HYU01_RS01620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYU01_RS01630	COG0151	Belongs to the GarS family
HYU01_RS01655	COG0210	DNA helicase
HYU01_RS01665	COG4851	CamS sex pheromone cAM373 precursor
HYU01_RS01685	COG1335	isochorismatase
HYU01_RS01690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYU01_RS01695	COG2011	ABC-type metal ion transport system permease component
HYU01_RS01700	COG1464	Belongs to the NlpA lipoprotein family
HYU01_RS01720	COG1846	Transcriptional regulator
HYU01_RS01745	COG1597	lipid kinase activity
HYU01_RS01750	COG0546	phosphoglycolate phosphatase activity
HYU01_RS01755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HYU01_RS01765	COG1012	belongs to the aldehyde dehydrogenase family
HYU01_RS01770	COG2076	Multidrug Resistance protein
HYU01_RS01775	COG2309	aminopeptidase activity
HYU01_RS01790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HYU01_RS01795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYU01_RS01800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYU01_RS01810	COG4807	Protein conserved in bacteria
HYU01_RS01835	COG1757	Na H antiporter
HYU01_RS01840	COG1473	amidohydrolase
HYU01_RS01855	COG0450	alkyl hydroperoxide reductase
HYU01_RS01875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYU01_RS01880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYU01_RS01885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYU01_RS01905	COG0166	Belongs to the GPI family
HYU01_RS01940	COG5002	protein histidine kinase activity
HYU01_RS01960	COG3541	Predicted nucleotidyltransferase
HYU01_RS01965	COG2814	Major facilitator Superfamily
HYU01_RS01970	COG0723	plastoquinol--plastocyanin reductase activity
HYU01_RS01970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYU01_RS01980	COG0765	amino acid transport
HYU01_RS01985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYU01_RS02005	COG0840	transmembrane signaling receptor activity
HYU01_RS02010	COG0366	Alpha amylase catalytic
HYU01_RS02015	COG1263	PTS System
HYU01_RS02015	COG2190	(PTS) system
HYU01_RS02015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYU01_RS02045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HYU01_RS02060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYU01_RS02070	COG1116	anion transmembrane transporter activity
HYU01_RS02075	COG0488	(ABC) transporter
HYU01_RS02120	COG2270	Major facilitator Superfamily
HYU01_RS02135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYU01_RS02150	COG2310	stress, protein
HYU01_RS02155	COG2310	stress, protein
HYU01_RS02160	COG2310	stress, protein
HYU01_RS02165	COG0861	Integral membrane protein TerC family
HYU01_RS02175	COG3853	Toxic anion resistance protein (TelA)
HYU01_RS02190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYU01_RS02200	COG1295	ribonuclease BN
HYU01_RS02205	COG2217	Heavy metal translocating P-type atpase
HYU01_RS02210	COG0697	spore germination
HYU01_RS02230	COG0586	Pfam SNARE associated Golgi protein
HYU01_RS02245	COG3871	stress protein (general stress protein 26)
HYU01_RS02250	COG0387	Pfam Sodium calcium exchanger
HYU01_RS02260	COG0535	radical SAM domain protein
HYU01_RS02285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HYU01_RS02290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYU01_RS02295	COG0582	viral genome integration into host DNA
HYU01_RS02300	COG1396	sequence-specific DNA binding
HYU01_RS02315	COG1396	sequence-specific DNA binding
HYU01_RS02350	COG1484	DNA-dependent DNA replication
HYU01_RS02445	COG0582	viral genome integration into host DNA
HYU01_RS02450	COG0582	viral genome integration into host DNA
HYU01_RS02570	COG0101	tRNA pseudouridine synthase activity
HYU01_RS02580	COG3829	transcription factor binding
HYU01_RS02590	COG0833	amino acid
HYU01_RS02595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYU01_RS02630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYU01_RS02630	COG1263	PTS System
HYU01_RS02635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYU01_RS02650	COG0463	Glycosyl transferase, family 2
HYU01_RS02665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYU01_RS02665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYU01_RS02685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYU01_RS02705	COG1228	amidohydrolase
HYU01_RS02710	COG1090	epimerase
HYU01_RS02740	COG1988	membrane-bound metal-dependent
HYU01_RS02745	COG1194	a g-specific adenine glycosylase
HYU01_RS02770	COG1132	(ABC) transporter
HYU01_RS02775	COG4129	membrane
HYU01_RS02780	COG0067	glutamate synthase
HYU01_RS02780	COG0069	glutamate synthase activity
HYU01_RS02780	COG0070	glutamate synthase
HYU01_RS02790	COG4555	ABC transporter
HYU01_RS02810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYU01_RS02815	COG0735	belongs to the Fur family
HYU01_RS02930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HYU01_RS02935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HYU01_RS02945	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYU01_RS02955	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HYU01_RS02970	COG2766	serine protein kinase
HYU01_RS02995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYU01_RS03005	COG1585	Membrane protein implicated in regulation of membrane protease activity
HYU01_RS03010	COG2268	Band 7 protein
HYU01_RS03020	COG3290	protein histidine kinase activity
HYU01_RS03025	COG4565	transcriptional regulatory protein
HYU01_RS03030	COG2851	Citrate transporter
HYU01_RS03050	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HYU01_RS03055	COG3842	ATPase activity
HYU01_RS03060	COG1175	transmembrane transport
HYU01_RS03065	COG0395	ABC-type sugar transport system, permease component
HYU01_RS03075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HYU01_RS03080	COG0745	RESPONSE REGULATOR receiver
HYU01_RS03085	COG5002	protein histidine kinase activity
HYU01_RS03095	COG4990	cell redox homeostasis
HYU01_RS03105	COG3290	protein histidine kinase activity
HYU01_RS03110	COG4565	transcriptional regulatory protein
HYU01_RS03115	COG3493	citrate carrier protein
HYU01_RS03120	COG0281	malic enzyme
HYU01_RS03135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYU01_RS03145	COG5002	protein histidine kinase activity
HYU01_RS03150	COG0745	RESPONSE REGULATOR receiver
HYU01_RS03160	COG0454	-acetyltransferase
HYU01_RS03160	COG0456	acetyltransferase
HYU01_RS03165	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HYU01_RS03170	COG3383	formate dehydrogenase (NAD+) activity
HYU01_RS03175	COG2427	Protein of unknown function (DUF1641)
HYU01_RS03190	COG0531	amino acid
HYU01_RS03195	COG0640	Transcriptional regulator
HYU01_RS03200	COG2217	Heavy metal translocating P-type atpase
HYU01_RS03205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HYU01_RS03215	COG3227	Zinc metalloprotease (Elastase)
HYU01_RS03235	COG2720	vancomycin resistance protein
HYU01_RS03240	COG1316	TRANSCRIPTIONal
HYU01_RS03245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HYU01_RS03250	COG0346	lactoylglutathione lyase activity
HYU01_RS03255	COG1253	flavin adenine dinucleotide binding
HYU01_RS03260	COG1027	Aspartate ammonia-lyase
HYU01_RS03265	COG1620	l-lactate permease
HYU01_RS03280	COG3104	oligopeptide transport
HYU01_RS03285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYU01_RS03290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYU01_RS03295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYU01_RS03305	COG2226	methyltransferase
HYU01_RS03310	COG0156	8-amino-7-oxononanoate synthase activity
HYU01_RS03315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYU01_RS03325	COG4548	von Willebrand factor, type A
HYU01_RS03330	COG0714	Associated with various cellular activities
HYU01_RS03335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYU01_RS03355	COG0531	amino acid
HYU01_RS03360	COG2188	Transcriptional regulator
HYU01_RS03365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYU01_RS03365	COG1263	PTS System
HYU01_RS03370	COG0366	Alpha amylase catalytic
HYU01_RS03385	COG0697	spore germination
HYU01_RS03395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HYU01_RS03400	COG1115	amino acid carrier protein
HYU01_RS03405	COG1126	abc transporter atp-binding protein
HYU01_RS03410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYU01_RS03415	COG0765	amino acid transport
HYU01_RS03420	COG0765	amino acid transport
HYU01_RS03425	COG0833	amino acid
HYU01_RS03450	COG2378	regulation of single-species biofilm formation
HYU01_RS03455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYU01_RS03460	COG5002	protein histidine kinase activity
HYU01_RS03475	COG0659	secondary active sulfate transmembrane transporter activity
HYU01_RS03490	COG0747	negative chemotaxis
HYU01_RS03500	COG0601	transmembrane transport
HYU01_RS03505	COG4608	Belongs to the ABC transporter superfamily
HYU01_RS03515	COG2271	Major facilitator Superfamily
HYU01_RS03520	COG1846	Transcriptional regulator
HYU01_RS03525	COG0477	Major facilitator Superfamily
HYU01_RS03530	COG0477	Major facilitator Superfamily
HYU01_RS03535	COG1609	Transcriptional regulator
HYU01_RS03540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYU01_RS03555	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYU01_RS03560	COG1879	ABC-type sugar transport system periplasmic component
HYU01_RS03585	COG1063	alcohol dehydrogenase
HYU01_RS03600	COG3568	Endonuclease Exonuclease Phosphatase
HYU01_RS03625	COG1968	undecaprenyl-diphosphatase activity
HYU01_RS03630	COG0840	transmembrane signaling receptor activity
HYU01_RS03635	COG3584	3D domain protein
HYU01_RS03635	COG1388	LysM domain
HYU01_RS03640	COG1476	TRANSCRIPTIONal
HYU01_RS03655	COG3104	oligopeptide transport
HYU01_RS03660	COG1114	Component of the transport system for branched-chain amino acids
HYU01_RS03675	COG1113	amino acid transport
HYU01_RS03680	COG2252	PERMEase
HYU01_RS03705	COG0569	domain protein
HYU01_RS03705	COG0475	glutathione-regulated potassium exporter activity
HYU01_RS03720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HYU01_RS03725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HYU01_RS03730	COG0833	amino acid
HYU01_RS03735	COG4990	cell redox homeostasis
HYU01_RS03750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYU01_RS03755	COG0697	spore germination
HYU01_RS03760	COG0531	amino acid
HYU01_RS03775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYU01_RS03780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYU01_RS03785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYU01_RS03785	COG1918	ferrous iron import across plasma membrane
HYU01_RS03790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HYU01_RS03795	COG0573	inorganic phosphate transmembrane transporter activity
HYU01_RS03800	COG0581	inorganic phosphate transmembrane transporter activity
HYU01_RS03810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYU01_RS03850	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYU01_RS03930	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HYU01_RS03955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HYU01_RS03960	COG1116	anion transmembrane transporter activity
HYU01_RS03965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYU01_RS03970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYU01_RS03975	COG0352	thiamine-phosphate diphosphorylase activity
HYU01_RS03980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYU01_RS03985	COG2104	thiamine diphosphate biosynthetic process
HYU01_RS03995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HYU01_RS04000	COG0351	phosphomethylpyrimidine kinase
HYU01_RS04045	COG2205	protein histidine kinase activity
HYU01_RS04050	COG2814	Major facilitator Superfamily
HYU01_RS04055	COG1846	Transcriptional regulator
HYU01_RS04070	COG2252	PERMEase
HYU01_RS04075	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS04080	COG1376	ErfK ybiS ycfS ynhG family protein
HYU01_RS04090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYU01_RS04095	COG1621	beta-fructofuranosidase activity
HYU01_RS04100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYU01_RS04100	COG1263	PTS System
HYU01_RS04105	COG1609	Transcriptional regulator
HYU01_RS04115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYU01_RS04155	COG0778	Nitroreductase
HYU01_RS04160	COG2719	SpoVR family
HYU01_RS04185	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYU01_RS04190	COG1937	Protein conserved in bacteria
HYU01_RS04195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYU01_RS04195	COG0425	Belongs to the sulfur carrier protein TusA family
HYU01_RS04200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYU01_RS04200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYU01_RS04205	COG0425	Belongs to the sulfur carrier protein TusA family
HYU01_RS04210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYU01_RS04220	COG2210	Belongs to the sulfur carrier protein TusA family
HYU01_RS04225	COG0730	response to heat
HYU01_RS04235	COG1316	TRANSCRIPTIONal
HYU01_RS04240	COG0604	alcohol dehydrogenase
HYU01_RS04245	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYU01_RS04260	COG3711	transcriptional antiterminator
HYU01_RS04260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYU01_RS04265	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYU01_RS04270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYU01_RS04290	COG1388	LysM domain
HYU01_RS04290	COG3584	3D domain protein
HYU01_RS04295	COG0577	efflux transmembrane transporter activity
HYU01_RS04300	COG1136	(ABC) transporter
HYU01_RS04310	COG5522	Integral membrane protein (intg_mem_TP0381)
HYU01_RS04325	COG1114	Component of the transport system for branched-chain amino acids
HYU01_RS04330	COG3546	catalase activity
HYU01_RS04365	COG0586	Pfam SNARE associated Golgi protein
HYU01_RS04405	COG0531	amino acid
HYU01_RS04410	COG0475	glutathione-regulated potassium exporter activity
HYU01_RS04420	COG1737	Transcriptional regulator
HYU01_RS04430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYU01_RS04430	COG1263	PTS System
HYU01_RS04440	COG2259	Doxx family
HYU01_RS04455	COG0697	spore germination
HYU01_RS04460	COG1522	sequence-specific DNA binding
HYU01_RS04475	COG2076	Multidrug Resistance protein
HYU01_RS04480	COG1309	transcriptional regulator
HYU01_RS04485	COG2814	Major facilitator Superfamily
HYU01_RS04490	COG1733	regulation of RNA biosynthetic process
HYU01_RS04500	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYU01_RS04505	COG4533	DNA binding
HYU01_RS04510	COG2211	Major facilitator Superfamily
HYU01_RS04520	COG0693	protein deglycase activity
HYU01_RS04525	COG0693	protein deglycase activity
HYU01_RS04525	COG0753	catalase activity
HYU01_RS04535	COG0531	amino acid
HYU01_RS04540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYU01_RS04550	COG1012	belongs to the aldehyde dehydrogenase family
HYU01_RS04560	COG1132	(ABC) transporter
HYU01_RS04575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYU01_RS04580	COG0765	amino acid transport
HYU01_RS04585	COG1126	abc transporter atp-binding protein
HYU01_RS04600	COG0189	ligase activity
HYU01_RS04630	COG0028	Belongs to the TPP enzyme family
HYU01_RS04635	COG3527	Alpha-acetolactate decarboxylase
HYU01_RS04650	COG0561	phosphatase activity
HYU01_RS04665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYU01_RS04680	COG0659	secondary active sulfate transmembrane transporter activity
HYU01_RS04700	COG0653	protein targeting
HYU01_RS04705	COG2244	polysaccharide biosynthetic process
HYU01_RS04715	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYU01_RS04720	COG4196	transglutaminase domain protein
HYU01_RS04735	COG1696	Membrane protein involved in D-alanine export
HYU01_RS04750	COG1024	Enoyl-CoA hydratase
HYU01_RS04770	COG1363	Peptidase, m42
HYU01_RS04790	COG3938	Belongs to the proline racemase family
HYU01_RS04830	COG0601	transmembrane transport
HYU01_RS04835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYU01_RS04845	COG4608	Belongs to the ABC transporter superfamily
HYU01_RS04875	COG0477	Major facilitator Superfamily
HYU01_RS04880	COG3290	protein histidine kinase activity
HYU01_RS04885	COG4565	transcriptional regulatory protein
HYU01_RS04890	COG3181	Tripartite tricarboxylate transporter family receptor
HYU01_RS04920	COG0789	Transcriptional regulator
HYU01_RS04920	COG4978	Transcriptional regulator
HYU01_RS04935	COG0305	Participates in initiation and elongation during chromosome replication
HYU01_RS04975	COG0477	Major facilitator Superfamily
HYU01_RS05030	COG1309	transcriptional regulator
HYU01_RS05050	COG1183	phosphatidylcholine synthase activity
HYU01_RS05070	COG2376	Dihydroxyacetone kinase
HYU01_RS05085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HYU01_RS05090	COG1959	2 iron, 2 sulfur cluster binding
HYU01_RS05115	COG2770	Histidine kinase
HYU01_RS05115	COG3437	response regulator, receiver
HYU01_RS05165	COG3237	CsbD-like
HYU01_RS05190	COG1191	sigma factor activity
HYU01_RS05200	COG2208	phosphoserine phosphatase activity
HYU01_RS05205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYU01_RS05210	COG0784	Response regulator, receiver
HYU01_RS05210	COG2205	protein histidine kinase activity
HYU01_RS05210	COG2198	Histidine kinase
HYU01_RS05210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYU01_RS05270	COG0420	3'-5' exonuclease activity
HYU01_RS05275	COG4717	serine-type aminopeptidase activity
HYU01_RS05295	COG1309	transcriptional regulator
HYU01_RS05300	COG2814	Major facilitator Superfamily
HYU01_RS05305	COG0346	lactoylglutathione lyase activity
HYU01_RS05310	COG0346	lactoylglutathione lyase activity
HYU01_RS05315	COG0457	Tetratricopeptide repeat
HYU01_RS05320	COG2267	carboxylic ester hydrolase activity
HYU01_RS05340	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HYU01_RS05345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HYU01_RS05355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HYU01_RS05395	COG0477	Major facilitator Superfamily
HYU01_RS05400	COG0477	Major facilitator Superfamily
HYU01_RS05410	COG3973	AAA domain
HYU01_RS05415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYU01_RS05440	COG4980	gas vesicle protein
HYU01_RS05445	COG0537	adenosine 5'-monophosphoramidase activity
HYU01_RS05450	COG1131	(ABC) transporter
HYU01_RS05455	COG4473	ABC transporter
HYU01_RS05465	COG1309	transcriptional regulator
HYU01_RS05475	COG3402	PFAM membrane-flanked domain
HYU01_RS05485	COG3428	Bacterial PH domain
HYU01_RS05530	COG3402	PFAM membrane-flanked domain
HYU01_RS05535	COG3428	Bacterial PH domain
HYU01_RS05540	COG2329	Antibiotic biosynthesis monooxygenase
HYU01_RS05545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYU01_RS05550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYU01_RS05555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HYU01_RS05560	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HYU01_RS05595	COG1309	transcriptional regulator
HYU01_RS05600	COG1511	domain protein
HYU01_RS05625	COG1609	Transcriptional regulator
HYU01_RS05635	COG1234	tRNA 3'-trailer cleavage
HYU01_RS05640	COG0095	Lipoate-protein ligase
HYU01_RS05650	COG0318	PFAM AMP-dependent synthetase and ligase
HYU01_RS05680	COG3209	COG3209 Rhs family protein
HYU01_RS05725	COG1408	metallophosphoesterase
HYU01_RS05730	COG1078	dGTPase activity
HYU01_RS05740	COG1595	DNA-templated transcription, initiation
HYU01_RS05745	COG3708	Transcriptional regulator
HYU01_RS05745	COG2207	Transcriptional regulator
HYU01_RS05760	COG2205	protein histidine kinase activity
HYU01_RS05765	COG0745	RESPONSE REGULATOR receiver
HYU01_RS05790	COG0501	Belongs to the peptidase M48B family
HYU01_RS05795	COG0840	transmembrane signaling receptor activity
HYU01_RS05800	COG0697	spore germination
HYU01_RS05820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HYU01_RS05825	COG2224	Isocitrate lyase
HYU01_RS05850	COG4903	ComK protein
HYU01_RS05855	COG0398	Pfam SNARE associated Golgi protein
HYU01_RS05865	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HYU01_RS05870	COG1074	ATP-dependent DNA helicase activity
HYU01_RS05915	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYU01_RS05940	COG0367	asparagine synthase
HYU01_RS05945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HYU01_RS05950	COG0753	catalase activity
HYU01_RS05955	COG0004	ammonium transporteR
HYU01_RS05980	COG2996	Protein conserved in bacteria
HYU01_RS05990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYU01_RS06000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYU01_RS06015	COG0561	phosphatase activity
HYU01_RS06030	COG0542	response to heat
HYU01_RS06040	COG2267	carboxylic ester hydrolase activity
HYU01_RS06055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYU01_RS06060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYU01_RS06065	COG5504	Zn-dependent protease
HYU01_RS06075	COG0180	Tryptophanyl-tRNA synthetase
HYU01_RS06085	COG4166	transmembrane transport
HYU01_RS06090	COG0601	transmembrane transport
HYU01_RS06095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYU01_RS06100	COG0444	Belongs to the ABC transporter superfamily
HYU01_RS06105	COG4608	Belongs to the ABC transporter superfamily
HYU01_RS06110	COG0534	Mate efflux family protein
HYU01_RS06115	COG4166	transmembrane transport
HYU01_RS06135	COG0861	Integral membrane protein TerC family
HYU01_RS06140	COG4862	establishment of competence for transformation
HYU01_RS06145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYU01_RS06155	COG1164	Oligoendopeptidase f
HYU01_RS06165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYU01_RS06170	COG2346	COG2346, Truncated hemoglobins
HYU01_RS06175	COG4116	CYTH
HYU01_RS06185	COG2357	RelA SpoT domain protein
HYU01_RS06195	COG0564	pseudouridine synthase activity
HYU01_RS06210	COG0772	Belongs to the SEDS family
HYU01_RS06215	COG0463	Glycosyl transferase, family 2
HYU01_RS06215	COG1216	Glycosyl transferase, family 2
HYU01_RS06235	COG0457	Tetratricopeptide repeat
HYU01_RS06235	COG0463	Glycosyl transferase, family 2
HYU01_RS06255	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HYU01_RS06270	COG1091	dTDP-4-dehydrorhamnose reductase activity
HYU01_RS06315	COG2153	protein acetylation
HYU01_RS06325	COG2382	esterase
HYU01_RS06340	COG5492	domain, Protein
HYU01_RS06345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYU01_RS06360	COG0512	Glutamine amidotransferase of anthranilate synthase
HYU01_RS06360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYU01_RS06395	COG1620	l-lactate permease
HYU01_RS06400	COG5634	Uncharacterized conserved protein (DUF2278)
HYU01_RS06450	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYU01_RS06460	COG1476	TRANSCRIPTIONal
HYU01_RS06520	COG2226	methyltransferase
HYU01_RS06530	COG1686	Belongs to the peptidase S11 family
HYU01_RS06535	COG0681	Belongs to the peptidase S26 family
HYU01_RS06570	COG1012	belongs to the aldehyde dehydrogenase family
HYU01_RS06575	COG3842	ATPase activity
HYU01_RS06580	COG1176	ABC-type spermidine putrescine transport system, permease component I
HYU01_RS06585	COG1177	transmembrane transport
HYU01_RS06590	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HYU01_RS06600	COG2409	Drug exporters of the RND superfamily
HYU01_RS06610	COG0564	pseudouridine synthase activity
HYU01_RS06620	COG2340	Cysteine-rich secretory protein family
HYU01_RS06625	COG0247	lactate metabolic process
HYU01_RS06630	COG0277	FAD linked oxidase domain protein
HYU01_RS06635	COG3835	regulator
HYU01_RS06645	COG0745	RESPONSE REGULATOR receiver
HYU01_RS06650	COG5002	protein histidine kinase activity
HYU01_RS06655	COG2186	Transcriptional regulator
HYU01_RS06675	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HYU01_RS06685	COG2116	formate transmembrane transporter activity
HYU01_RS06690	COG0861	Integral membrane protein TerC family
HYU01_RS06705	COG2030	dehydratase
HYU01_RS06725	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS06730	COG3243	poly(R)-hydroxyalkanoic acid synthase
HYU01_RS06735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYU01_RS06740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYU01_RS06755	COG1840	ABC-type Fe3 transport system, periplasmic component
HYU01_RS06785	COG1349	DNA-binding transcription factor activity
HYU01_RS06810	COG2861	carbohydrate metabolic process
HYU01_RS06820	COG3852	Histidine kinase
HYU01_RS06825	COG1846	Transcriptional regulator
HYU01_RS06835	COG2318	DinB family
HYU01_RS06845	COG5002	protein histidine kinase activity
HYU01_RS06855	COG0720	synthase
HYU01_RS06870	COG4873	Protein conserved in bacteria
HYU01_RS06905	COG1780	Probably involved in ribonucleotide reductase function
HYU01_RS06920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYU01_RS06925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYU01_RS06930	COG1725	Transcriptional regulator
HYU01_RS06935	COG1131	(ABC) transporter
HYU01_RS06945	COG1131	(ABC) transporter
HYU01_RS06950	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HYU01_RS06965	COG1522	sequence-specific DNA binding
HYU01_RS06975	COG1335	isochorismatase
HYU01_RS06985	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYU01_RS06990	COG2070	2-Nitropropane dioxygenase
HYU01_RS06995	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HYU01_RS07005	COG1696	Membrane protein involved in D-alanine export
HYU01_RS07030	COG0716	FMN binding
HYU01_RS07045	COG3173	Aminoglycoside phosphotransferase
HYU01_RS07065	COG0534	Mate efflux family protein
HYU01_RS07070	COG1968	undecaprenyl-diphosphatase activity
HYU01_RS07085	COG1846	Transcriptional regulator
HYU01_RS07095	COG1301	dicarboxylic acid transport
HYU01_RS07100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYU01_RS07105	COG4709	membrane
HYU01_RS07110	COG3874	Sporulation protein YtfJ
HYU01_RS07140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYU01_RS07145	COG0028	Belongs to the TPP enzyme family
HYU01_RS07150	COG0440	acetolactate synthase activity
HYU01_RS07155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HYU01_RS07165	COG0473	3-isopropylmalate dehydrogenase activity
HYU01_RS07190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HYU01_RS07225	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYU01_RS07240	COG1183	phosphatidylcholine synthase activity
HYU01_RS07245	COG1368	sulfuric ester hydrolase activity
HYU01_RS07255	COG0019	diaminopimelate decarboxylase activity
HYU01_RS07275	COG0529	Catalyzes the synthesis of activated sulfate
HYU01_RS07280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYU01_RS07300	COG1648	precorrin-2 dehydrogenase activity
HYU01_RS07310	COG0733	neurotransmitter:sodium symporter activity
HYU01_RS07330	COG1757	Na H antiporter
HYU01_RS07345	COG4758	membrane
HYU01_RS07350	COG4585	Histidine kinase
HYU01_RS07355	COG2197	response regulator
HYU01_RS07365	COG1114	Component of the transport system for branched-chain amino acids
HYU01_RS07375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYU01_RS07400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYU01_RS07400	COG1017	nitric oxide dioxygenase activity
HYU01_RS07420	COG0730	response to heat
HYU01_RS07425	COG0306	phosphate transporter
HYU01_RS07430	COG1392	Phosphate transport regulator
HYU01_RS07435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYU01_RS07450	COG3852	Histidine kinase
HYU01_RS07455	COG1801	Protein of unknown function DUF72
HYU01_RS07465	COG0582	viral genome integration into host DNA
HYU01_RS07470	COG5002	protein histidine kinase activity
HYU01_RS07490	COG0392	lysyltransferase activity
HYU01_RS07490	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HYU01_RS07505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYU01_RS07510	COG1686	Belongs to the peptidase S11 family
HYU01_RS07515	COG2715	membrane protein required for spore maturation
HYU01_RS07520	COG0700	Nucleoside recognition
HYU01_RS07525	COG1187	pseudouridine synthase activity
HYU01_RS07535	COG1333	cytochrome c biogenesis protein
HYU01_RS07540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYU01_RS07545	COG0745	RESPONSE REGULATOR receiver
HYU01_RS07550	COG5002	protein histidine kinase activity
HYU01_RS07555	COG2096	Adenosyltransferase
HYU01_RS07570	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HYU01_RS07575	COG1141	Ferredoxin
HYU01_RS07580	COG4955	Helix-turn-helix domain
HYU01_RS07585	COG0514	ATP-dependent DNA helicase (RecQ)
HYU01_RS07590	COG1266	CAAX protease self-immunity
HYU01_RS07610	COG4862	establishment of competence for transformation
HYU01_RS07615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYU01_RS07635	COG0492	ferredoxin-NADP+ reductase activity
HYU01_RS07640	COG0252	asparaginase activity
HYU01_RS07710	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HYU01_RS07725	COG0142	geranyltranstransferase activity
HYU01_RS07735	COG0142	geranyltranstransferase activity
HYU01_RS07755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYU01_RS07760	COG0457	Tetratricopeptide repeat
HYU01_RS07780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HYU01_RS07790	COG4347	Protein of unknown function (DUF1405)
HYU01_RS07805	COG2738	Putative neutral zinc metallopeptidase
HYU01_RS07815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYU01_RS07820	COG1694	Mazg nucleotide pyrophosphohydrolase
HYU01_RS07835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYU01_RS07840	COG0438	transferase activity, transferring glycosyl groups
HYU01_RS07900	COG3935	DnaD domain protein
HYU01_RS07905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYU01_RS07915	COG4499	WXG100 protein secretion system (Wss), protein YukC
HYU01_RS07915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYU01_RS07965	COG0116	Belongs to the methyltransferase superfamily
HYU01_RS07975	COG1199	ATP-dependent helicase activity
HYU01_RS07980	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HYU01_RS07990	COG3173	Aminoglycoside phosphotransferase
HYU01_RS07995	COG0024	Methionine aminopeptidase
HYU01_RS08005	COG2233	PERMEase
HYU01_RS08010	COG2311	Membrane
HYU01_RS08015	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HYU01_RS08025	COG0456	acetyltransferase
HYU01_RS08050	COG0754	glutathionylspermidine amidase activity
HYU01_RS08065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYU01_RS08090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYU01_RS08105	COG1215	transferase activity, transferring glycosyl groups
HYU01_RS08125	COG0454	-acetyltransferase
HYU01_RS08150	COG0328	RNA-DNA hybrid ribonuclease activity
HYU01_RS08190	COG1280	lysine exporter protein (LysE YggA)
HYU01_RS08205	COG3162	membrane
HYU01_RS08210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYU01_RS08215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYU01_RS08225	COG0475	glutathione-regulated potassium exporter activity
HYU01_RS08230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYU01_RS08235	COG0789	Transcriptional regulator
HYU01_RS08235	COG4978	Transcriptional regulator
HYU01_RS08245	COG2323	membrane
HYU01_RS08250	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HYU01_RS08305	COG1923	regulation of RNA biosynthetic process
HYU01_RS08315	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HYU01_RS08320	COG1360	Flagellar Motor Protein
HYU01_RS08325	COG2201	protein-glutamate methylesterase activity
HYU01_RS08335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYU01_RS08335	COG1776	CheC inhibitor of MCP methylation
HYU01_RS08350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYU01_RS08370	COG1256	bacterial-type flagellum assembly
HYU01_RS08375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYU01_RS08400	COG1815	bacterial-type flagellum-dependent cell motility
HYU01_RS08405	COG1558	bacterial-type flagellum-dependent cell motility
HYU01_RS08415	COG1766	The M ring may be actively involved in energy transduction
HYU01_RS08425	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYU01_RS08435	COG1157	protein secretion by the type III secretion system
HYU01_RS08475	COG0835	chemotaxis
HYU01_RS08475	COG0784	Response regulator, receiver
HYU01_RS08485	COG0463	Glycosyl transferase, family 2
HYU01_RS08515	COG0463	Glycosyl transferase, family 2
HYU01_RS08515	COG0457	Tetratricopeptide repeat
HYU01_RS08540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYU01_RS08545	COG0741	lytic transglycosylase activity
HYU01_RS08560	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYU01_RS08560	COG1776	CheC inhibitor of MCP methylation
HYU01_RS08570	COG1338	Plays a role in the flagellum-specific transport system
HYU01_RS08575	COG1987	bacterial-type flagellum assembly
HYU01_RS08585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYU01_RS08590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYU01_RS08595	COG1419	protein localization to endoplasmic reticulum
HYU01_RS08600	COG4786	Flagellar basal body rod
HYU01_RS08605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYU01_RS08630	COG1309	transcriptional regulator
HYU01_RS08650	COG2329	Antibiotic biosynthesis monooxygenase
HYU01_RS08680	COG3842	ATPase activity
HYU01_RS08685	COG0725	ABC transporter, periplasmic molybdate-binding protein
HYU01_RS08695	COG1234	tRNA 3'-trailer cleavage
HYU01_RS08720	COG1686	Belongs to the peptidase S11 family
HYU01_RS08730	COG0406	alpha-ribazole phosphatase activity
HYU01_RS08760	COG0367	asparagine synthase
HYU01_RS08790	COG1802	Transcriptional regulator
HYU01_RS08795	COG0697	spore germination
HYU01_RS08800	COG0523	cobalamin synthesis protein
HYU01_RS08805	COG0701	Predicted permease
HYU01_RS08815	COG0438	transferase activity, transferring glycosyl groups
HYU01_RS08815	COG1216	Glycosyl transferase, family 2
HYU01_RS08820	COG1757	Na H antiporter
HYU01_RS08825	COG0114	fumarate hydratase activity
HYU01_RS08855	COG3340	Belongs to the peptidase S51 family
HYU01_RS08875	COG0785	Cytochrome C biogenesis protein
HYU01_RS08910	COG2733	membrane
HYU01_RS08945	COG1131	(ABC) transporter
HYU01_RS08960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYU01_RS08965	COG0528	UMP kinase activity
HYU01_RS08975	COG1027	Aspartate ammonia-lyase
HYU01_RS08980	COG0281	malic enzyme
HYU01_RS08985	COG4191	Histidine kinase
HYU01_RS08990	COG0784	Response regulator, receiver
HYU01_RS08995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYU01_RS09060	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYU01_RS09070	COG2814	Major facilitator Superfamily
HYU01_RS09085	COG1966	Carbon starvation protein
HYU01_RS09095	COG0477	Major facilitator Superfamily
HYU01_RS09100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYU01_RS09110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYU01_RS09120	COG4166	transmembrane transport
HYU01_RS09145	COG2244	polysaccharide biosynthetic process
HYU01_RS09150	COG0733	neurotransmitter:sodium symporter activity
HYU01_RS09160	COG5566	PFAM Mor transcription activator
HYU01_RS09165	COG2323	membrane
HYU01_RS09180	COG2084	Dehydrogenase
HYU01_RS09195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYU01_RS09205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYU01_RS09210	COG0028	Belongs to the TPP enzyme family
HYU01_RS09215	COG0440	acetolactate synthase activity
HYU01_RS09220	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HYU01_RS09230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HYU01_RS09260	COG3384	dioxygenase
HYU01_RS09270	COG3279	Response regulator of the LytR AlgR family
HYU01_RS09275	COG0427	acetyl-CoA hydrolase
HYU01_RS09295	COG1073	alpha beta
HYU01_RS09300	COG4166	transmembrane transport
HYU01_RS09325	COG0535	radical SAM domain protein
HYU01_RS09330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYU01_RS09350	COG1914	H( )-stimulated, divalent metal cation uptake system
HYU01_RS09365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HYU01_RS09400	COG2390	Transcriptional regulator
HYU01_RS09410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HYU01_RS09415	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HYU01_RS09430	COG4224	UPF0291 protein
HYU01_RS09450	COG0006	proline dipeptidase activity
HYU01_RS09455	COG2132	Multicopper oxidase
HYU01_RS09470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYU01_RS09485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HYU01_RS09500	COG2372	response to copper ion
HYU01_RS09500	COG1276	copper resistance
HYU01_RS09505	COG4549	nuclear export factor GLE1
HYU01_RS09515	COG0697	spore germination
HYU01_RS09520	COG0583	DNA-binding transcription factor activity
HYU01_RS09525	COG1959	2 iron, 2 sulfur cluster binding
HYU01_RS09530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYU01_RS09535	COG0778	Nitroreductase
HYU01_RS09550	COG0628	permease
HYU01_RS09560	COG1231	oxidoreductase activity
HYU01_RS09565	COG0523	cobalamin synthesis protein
HYU01_RS09580	COG0318	PFAM AMP-dependent synthetase and ligase
HYU01_RS09585	COG2030	dehydratase
HYU01_RS09590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYU01_RS09600	COG0411	ABC transporter
HYU01_RS09620	COG0583	DNA-binding transcription factor activity
HYU01_RS09630	COG1942	4-Oxalocrotonate Tautomerase
HYU01_RS09640	COG1846	Transcriptional regulator
HYU01_RS09650	COG1271	oxidase subunit
HYU01_RS09655	COG1294	oxidase, subunit
HYU01_RS09660	COG4988	ABC transporter
HYU01_RS09665	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HYU01_RS09685	COG1686	Belongs to the peptidase S11 family
HYU01_RS09695	COG0791	NLP P60 protein
HYU01_RS09695	COG1388	LysM domain
HYU01_RS09705	COG1132	(ABC) transporter
HYU01_RS09710	COG1132	(ABC) transporter
HYU01_RS09715	COG0745	RESPONSE REGULATOR receiver
HYU01_RS09730	COG0300	oxidoreductase activity
HYU01_RS09765	COG0460	homoserine dehydrogenase
HYU01_RS09790	COG1316	TRANSCRIPTIONal
HYU01_RS09800	COG0745	RESPONSE REGULATOR receiver
HYU01_RS09805	COG5002	protein histidine kinase activity
HYU01_RS09820	COG1285	pathogenesis
HYU01_RS09825	COG1247	-acetyltransferase
HYU01_RS09845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYU01_RS09855	COG1082	Xylose isomerase domain protein TIM barrel
HYU01_RS09865	COG2814	Major facilitator Superfamily
HYU01_RS09870	COG1279	arginine transmembrane transporter activity
HYU01_RS09880	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYU01_RS09915	COG0577	efflux transmembrane transporter activity
HYU01_RS09920	COG2002	toxin-antitoxin pair type II binding
HYU01_RS09925	COG1404	Belongs to the peptidase S8 family
HYU01_RS09930	COG0640	Transcriptional regulator
HYU01_RS09935	COG0667	Aldo Keto reductase
HYU01_RS09965	COG0840	transmembrane signaling receptor activity
HYU01_RS09985	COG3949	Membrane
HYU01_RS09990	COG0783	Belongs to the Dps family
HYU01_RS10005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYU01_RS10015	COG1231	oxidoreductase activity
HYU01_RS10025	COG4989	oxidoreductase activity
HYU01_RS10030	COG0523	cobalamin synthesis protein
HYU01_RS10035	COG0456	acetyltransferase
HYU01_RS10100	COG0803	Belongs to the bacterial solute-binding protein 9 family
HYU01_RS10100	COG3443	Belongs to the bacterial solute-binding protein 9 family
HYU01_RS10110	COG0702	epimerase
HYU01_RS10120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYU01_RS10130	COG4166	transmembrane transport
HYU01_RS10145	COG0406	alpha-ribazole phosphatase activity
HYU01_RS10155	COG5337	Spore coat protein CotH
HYU01_RS10160	COG1051	belongs to the nudix hydrolase family
HYU01_RS10165	COG0586	Pfam SNARE associated Golgi protein
HYU01_RS10170	COG2244	polysaccharide biosynthetic process
HYU01_RS10180	COG0701	Predicted permease
HYU01_RS10185	COG3689	TIGRFAM TIGR03943 family protein
HYU01_RS10190	COG1607	acyl-coa hydrolase
HYU01_RS10195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYU01_RS10210	COG0702	epimerase
HYU01_RS10215	COG2839	Protein conserved in bacteria
HYU01_RS10220	COG1253	flavin adenine dinucleotide binding
HYU01_RS10235	COG1114	Component of the transport system for branched-chain amino acids
HYU01_RS10240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYU01_RS10260	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYU01_RS10270	COG1876	peptidase activity
HYU01_RS10280	COG0154	amidase activity
HYU01_RS10285	COG2211	Major facilitator Superfamily
HYU01_RS10305	COG0561	phosphatase activity
HYU01_RS10315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYU01_RS10320	COG4106	trans-aconitate 2-methyltransferase activity
HYU01_RS10335	COG1819	glycosyl
HYU01_RS10340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYU01_RS10345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYU01_RS10370	COG0456	acetyltransferase
HYU01_RS10420	COG3874	Sporulation protein YtfJ
HYU01_RS10465	COG1082	Xylose isomerase domain protein TIM barrel
HYU01_RS10470	COG0346	lactoylglutathione lyase activity
HYU01_RS10480	COG0604	alcohol dehydrogenase
HYU01_RS10485	COG1595	DNA-templated transcription, initiation
HYU01_RS10510	COG0386	Belongs to the glutathione peroxidase family
HYU01_RS10515	COG1305	Transglutaminase-like
HYU01_RS10520	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HYU01_RS10525	COG0714	Associated with various cellular activities
HYU01_RS10540	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HYU01_RS10545	COG1140	nitrate reductase beta subunit
HYU01_RS10550	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HYU01_RS10555	COG2181	nitrate reductase activity
HYU01_RS10575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYU01_RS10580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYU01_RS10585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HYU01_RS10590	COG0303	'Molybdopterin
HYU01_RS10595	COG0314	molybdopterin synthase activity
HYU01_RS10605	COG2223	nitrite transmembrane transporter activity
HYU01_RS10620	COG1648	precorrin-2 dehydrogenase activity
HYU01_RS10630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HYU01_RS10630	COG1587	Uroporphyrinogen-III synthase
HYU01_RS10635	COG2146	nitrite reductase [NAD(P)H] activity
HYU01_RS10645	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HYU01_RS10680	COG2359	stage V sporulation protein S
HYU01_RS10695	COG5632	N-Acetylmuramoyl-L-alanine amidase
HYU01_RS10710	COG1418	mRNA catabolic process
HYU01_RS10715	COG0488	(ABC) transporter
HYU01_RS10730	COG0629	single-stranded DNA binding
HYU01_RS10745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYU01_RS10750	COG1413	lyase activity
HYU01_RS10765	COG2521	methyltransferase
HYU01_RS10765	COG2136	Putative SAM-dependent methyltransferase
HYU01_RS10770	COG0018	arginyl-trna synthetase
HYU01_RS10795	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYU01_RS10810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYU01_RS10815	COG0017	Asparaginyl-tRNA synthetase
HYU01_RS10835	COG1674	ftsk spoiiie
HYU01_RS10930	COG1929	Belongs to the glycerate kinase type-1 family
HYU01_RS10935	COG0471	metal ion transport
HYU01_RS10940	COG0745	RESPONSE REGULATOR receiver
HYU01_RS10945	COG3850	Histidine kinase
HYU01_RS10945	COG5002	protein histidine kinase activity
HYU01_RS10960	COG0733	neurotransmitter:sodium symporter activity
HYU01_RS10985	COG2610	gluconate transmembrane transporter activity
HYU01_RS10990	COG1454	alcohol dehydrogenase
HYU01_RS10995	COG1794	racemase activity, acting on amino acids and derivatives
HYU01_RS11005	COG0456	acetyltransferase
HYU01_RS11020	COG1131	(ABC) transporter
HYU01_RS11025	COG4473	ABC transporter
HYU01_RS11035	COG0546	phosphoglycolate phosphatase activity
HYU01_RS11055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYU01_RS11070	COG0768	penicillin binding
HYU01_RS11075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HYU01_RS11080	COG0204	Acyl-transferase
HYU01_RS11085	COG1272	protein, Hemolysin III
HYU01_RS11095	COG0805	protein transport
HYU01_RS11105	COG1307	EDD domain protein, DegV family
HYU01_RS11110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HYU01_RS11115	COG1999	signal sequence binding
HYU01_RS11120	COG0071	Belongs to the small heat shock protein (HSP20) family
HYU01_RS11125	COG0367	asparagine synthase
HYU01_RS11145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYU01_RS11150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYU01_RS11185	COG0668	transmembrane transport
HYU01_RS11190	COG4585	Histidine kinase
HYU01_RS11190	COG2203	Gaf domain
HYU01_RS11195	COG2197	response regulator
HYU01_RS11205	COG1737	Transcriptional regulator
HYU01_RS11210	COG1064	alcohol dehydrogenase
HYU01_RS11240	COG1070	Carbohydrate kinase
HYU01_RS11245	COG1070	Carbohydrate kinase
HYU01_RS11275	COG0517	IMP dehydrogenase activity
HYU01_RS11275	COG1125	glycine betaine transport
HYU01_RS11280	COG1174	glycine betaine transport
HYU01_RS11315	COG1253	flavin adenine dinucleotide binding
HYU01_RS11320	COG1012	belongs to the aldehyde dehydrogenase family
HYU01_RS11325	COG5506	Protein of unknown function (DUF1694)
HYU01_RS11340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYU01_RS11345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYU01_RS11350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HYU01_RS11355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYU01_RS11360	COG0456	acetyltransferase
HYU01_RS11365	COG3829	transcription factor binding
HYU01_RS11370	COG1509	lysine 2,3-aminomutase activity
HYU01_RS11410	COG4326	sporulation control protein
HYU01_RS11415	COG0671	phosphoesterase, PA-phosphatase related
HYU01_RS11420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HYU01_RS11425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYU01_RS11455	COG1787	Restriction endonuclease
HYU01_RS11455	COG1715	Restriction endonuclease
HYU01_RS11545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYU01_RS11585	COG4499	WXG100 protein secretion system (Wss), protein YukC
HYU01_RS11585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYU01_RS11590	COG2814	Major facilitator Superfamily
HYU01_RS11595	COG4841	protein insertion into membrane
HYU01_RS11600	COG0372	Belongs to the citrate synthase family
HYU01_RS11605	COG2079	MmgE PrpD family protein
HYU01_RS11610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HYU01_RS11615	COG1960	acyl-CoA dehydrogenase activity
HYU01_RS11620	COG2084	Dehydrogenase
HYU01_RS11630	COG1280	lysine exporter protein (LysE YggA)
HYU01_RS11635	COG1024	Enoyl-CoA hydratase
HYU01_RS11650	COG0420	3'-5' exonuclease activity
HYU01_RS11655	COG0419	ATPase involved in DNA repair
HYU01_RS11685	COG2223	nitrite transmembrane transporter activity
HYU01_RS11690	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS11695	COG1169	isochorismate synthase
HYU01_RS11700	COG1021	2,3-dihydroxybenzoate-AMP ligase
HYU01_RS11705	COG3433	isochorismatase activity
HYU01_RS11705	COG1535	isochorismatase
HYU01_RS11715	COG3251	PFAM MbtH domain protein
HYU01_RS11720	COG2814	Major facilitator Superfamily
HYU01_RS11735	COG0776	regulation of translation
HYU01_RS11745	COG2318	DinB family
HYU01_RS11775	COG2329	Antibiotic biosynthesis monooxygenase
HYU01_RS11780	COG1187	pseudouridine synthase activity
HYU01_RS11785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYU01_RS11800	COG0596	Alpha beta hydrolase
HYU01_RS11805	COG2814	Major facilitator Superfamily
HYU01_RS11825	COG2226	methyltransferase
HYU01_RS11870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYU01_RS11905	COG1247	-acetyltransferase
HYU01_RS11935	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HYU01_RS11945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYU01_RS11955	COG1278	Cold shock
HYU01_RS11970	COG0010	Belongs to the arginase family
HYU01_RS11975	COG0561	phosphatase activity
HYU01_RS12025	COG0583	DNA-binding transcription factor activity
HYU01_RS12030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYU01_RS12045	COG0583	DNA-binding transcription factor activity
HYU01_RS12050	COG2258	MOSC domain
HYU01_RS12065	COG1132	(ABC) transporter
HYU01_RS12070	COG1132	(ABC) transporter
HYU01_RS12090	COG1396	sequence-specific DNA binding
HYU01_RS12115	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HYU01_RS12120	COG1595	DNA-templated transcription, initiation
HYU01_RS12145	COG1649	PFAM Uncharacterised BCR, COG1649
HYU01_RS12170	COG2971	BadF BadG BcrA BcrD
HYU01_RS12175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYU01_RS12180	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HYU01_RS12200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYU01_RS12230	COG1309	transcriptional regulator
HYU01_RS12245	COG0577	efflux transmembrane transporter activity
HYU01_RS12245	COG1136	(ABC) transporter
HYU01_RS12250	COG3615	Tellurite resistance protein tehB
HYU01_RS12250	COG0500	methyltransferase
HYU01_RS12260	COG2226	methyltransferase
HYU01_RS12265	COG3961	Belongs to the TPP enzyme family
HYU01_RS12270	COG1846	Transcriptional regulator
HYU01_RS12310	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYU01_RS12325	COG1595	DNA-templated transcription, initiation
HYU01_RS12335	COG0768	penicillin binding
HYU01_RS12340	COG0768	penicillin binding
HYU01_RS12345	COG2367	Beta-lactamase
HYU01_RS12350	COG0671	phosphoesterase, PA-phosphatase related
HYU01_RS12355	COG1609	Transcriptional regulator
HYU01_RS12365	COG0673	inositol 2-dehydrogenase activity
HYU01_RS12375	COG1012	belongs to the aldehyde dehydrogenase family
HYU01_RS12390	COG0191	fructose-bisphosphate aldolase activity
HYU01_RS12410	COG0737	Belongs to the 5'-nucleotidase family
HYU01_RS12420	COG0457	Tetratricopeptide repeat
HYU01_RS12425	COG1476	TRANSCRIPTIONal
HYU01_RS12440	COG1876	peptidase activity
HYU01_RS12460	COG1309	transcriptional regulator
HYU01_RS12465	COG0488	(ABC) transporter
HYU01_RS12480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYU01_RS12495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYU01_RS12510	COG1131	(ABC) transporter
HYU01_RS12520	COG1309	transcriptional regulator
HYU01_RS12535	COG1960	acyl-CoA dehydrogenase activity
HYU01_RS12540	COG0439	Biotin carboxylase
HYU01_RS12545	COG0511	ligase activity, forming carbon-carbon bonds
HYU01_RS12550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYU01_RS12555	COG1024	Enoyl-CoA hydratase
HYU01_RS12560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYU01_RS12565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYU01_RS12575	COG1247	-acetyltransferase
HYU01_RS12580	COG0572	uridine kinase
HYU01_RS12590	COG2318	DinB family
HYU01_RS12595	COG1686	Belongs to the peptidase S11 family
HYU01_RS12620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYU01_RS12685	COG2814	Major facilitator Superfamily
HYU01_RS12705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HYU01_RS12725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYU01_RS12740	COG1063	alcohol dehydrogenase
HYU01_RS12755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYU01_RS12760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYU01_RS12775	COG3773	Cell wall hydrolase
HYU01_RS12785	COG0745	RESPONSE REGULATOR receiver
HYU01_RS12800	COG0488	(ABC) transporter
HYU01_RS12815	COG1136	(ABC) transporter
HYU01_RS12840	COG0460	homoserine dehydrogenase
HYU01_RS12845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYU01_RS12855	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HYU01_RS12935	COG2124	cytochrome p450
HYU01_RS12970	COG0561	phosphatase activity
HYU01_RS12980	COG5002	protein histidine kinase activity
HYU01_RS12985	COG0768	penicillin binding
HYU01_RS12990	COG1819	glycosyl
HYU01_RS12995	COG1794	racemase activity, acting on amino acids and derivatives
HYU01_RS13005	COG1122	ATPase activity
HYU01_RS13015	COG2205	protein histidine kinase activity
HYU01_RS13025	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HYU01_RS13030	COG0604	alcohol dehydrogenase
HYU01_RS13035	COG0768	penicillin binding
HYU01_RS13045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYU01_RS13080	COG0693	protein deglycase activity
HYU01_RS13110	COG2814	Major facilitator Superfamily
HYU01_RS13125	COG0584	glycerophosphoryl diester phosphodiesterase
HYU01_RS13145	COG0697	spore germination
HYU01_RS13170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYU01_RS13180	COG2223	nitrite transmembrane transporter activity
HYU01_RS13195	COG2816	NAD+ diphosphatase activity
HYU01_RS13200	COG0592	DNA-directed DNA polymerase activity
HYU01_RS13205	COG1051	belongs to the nudix hydrolase family
HYU01_RS13240	COG3878	Protein conserved in bacteria
HYU01_RS13270	COG4667	esterase of the alpha-beta hydrolase superfamily
HYU01_RS13295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYU01_RS13310	COG0322	excinuclease ABC activity
HYU01_RS13350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYU01_RS13375	COG1011	Hydrolase
HYU01_RS13390	COG0657	acetylesterase activity
HYU01_RS13395	COG0076	glutamate decarboxylase activity
HYU01_RS13410	COG1523	belongs to the glycosyl hydrolase 13 family
HYU01_RS13415	COG3227	Zinc metalloprotease (Elastase)
HYU01_RS13435	COG0201	protein transport
HYU01_RS13445	COG0697	spore germination
HYU01_RS13450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYU01_RS13480	COG4129	membrane
HYU01_RS13485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYU01_RS13500	COG2959	enzyme of heme biosynthesis
HYU01_RS13520	COG3483	tryptophan 2,3-dioxygenase activity
HYU01_RS13525	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HYU01_RS13530	COG3844	kynureninase activity
HYU01_RS13535	COG1309	transcriptional regulator
HYU01_RS13565	COG3284	Transcriptional regulator
HYU01_RS13585	COG1349	DNA-binding transcription factor activity
HYU01_RS13605	COG1959	2 iron, 2 sulfur cluster binding
HYU01_RS13620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYU01_RS13625	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYU01_RS13630	COG0022	dehydrogenase e1 component
HYU01_RS13635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYU01_RS13645	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS13650	COG0456	acetyltransferase
HYU01_RS13650	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HYU01_RS13685	COG4176	ABC-type proline glycine betaine transport system permease component
HYU01_RS13690	COG4175	Glycine betaine
HYU01_RS13690	COG0517	IMP dehydrogenase activity
HYU01_RS13715	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HYU01_RS13720	COG2153	protein acetylation
HYU01_RS13725	COG3397	chitin binding
HYU01_RS13740	COG2205	protein histidine kinase activity
HYU01_RS13770	COG0658	competence protein
HYU01_RS13770	COG2333	competence protein COMEC
HYU01_RS13820	COG3973	AAA domain
HYU01_RS13835	COG2105	PFAM AIG2 family protein
HYU01_RS13840	COG0514	ATP-dependent DNA helicase (RecQ)
HYU01_RS13870	COG4637	Psort location Cytoplasmic, score
HYU01_RS13895	COG3397	chitin binding
HYU01_RS13905	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYU01_RS13910	COG1115	amino acid carrier protein
HYU01_RS13915	COG1012	belongs to the aldehyde dehydrogenase family
HYU01_RS13920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYU01_RS13930	COG3938	Belongs to the proline racemase family
HYU01_RS13935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYU01_RS13975	COG0586	Pfam SNARE associated Golgi protein
HYU01_RS13990	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HYU01_RS13995	COG0519	Catalyzes the synthesis of GMP from XMP
HYU01_RS14000	COG4166	transmembrane transport
HYU01_RS14010	COG4948	Mandelate Racemase Muconate Lactonizing
HYU01_RS14050	COG2936	dipeptidyl-peptidase activity
HYU01_RS14055	COG5002	protein histidine kinase activity
HYU01_RS14060	COG0745	RESPONSE REGULATOR receiver
HYU01_RS14100	COG1307	EDD domain protein, DegV family
HYU01_RS14120	COG2814	Major facilitator Superfamily
HYU01_RS14130	COG1664	Polymer-forming cytoskeletal
HYU01_RS14135	COG0789	Transcriptional regulator
HYU01_RS14140	COG4533	DNA binding
HYU01_RS14145	COG0477	Major facilitator Superfamily
HYU01_RS14145	COG2814	Major facilitator Superfamily
HYU01_RS14165	COG2261	transglycosylase associated protein
HYU01_RS14180	COG2226	methyltransferase
HYU01_RS14215	COG0436	Aminotransferase
HYU01_RS14220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYU01_RS14225	COG5146	pantothenate kinase activity
HYU01_RS14245	COG1131	(ABC) transporter
HYU01_RS14300	COG0628	permease
HYU01_RS14315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYU01_RS14320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYU01_RS14325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYU01_RS14330	COG1116	anion transmembrane transporter activity
HYU01_RS14350	COG2816	NAD+ diphosphatase activity
HYU01_RS14370	COG2746	aminoglycoside 3-N-acetyltransferase activity
HYU01_RS14395	COG0697	spore germination
HYU01_RS14400	COG2318	DinB family
HYU01_RS14420	COG4912	Dna alkylation repair
HYU01_RS14440	COG0861	Integral membrane protein TerC family
HYU01_RS14445	COG1368	sulfuric ester hydrolase activity
HYU01_RS14450	COG0488	(ABC) transporter
HYU01_RS14460	COG1033	growth of symbiont in host cell
HYU01_RS14460	COG2409	Drug exporters of the RND superfamily
HYU01_RS14465	COG1033	growth of symbiont in host cell
HYU01_RS14465	COG2409	Drug exporters of the RND superfamily
HYU01_RS14470	COG1309	transcriptional regulator
HYU01_RS14485	COG0287	Prephenate dehydrogenase
HYU01_RS14490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYU01_RS14495	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYU01_RS14500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HYU01_RS14500	COG1605	Chorismate mutase
HYU01_RS14535	COG1388	LysM domain
HYU01_RS14535	COG3584	3D domain protein
HYU01_RS14545	COG1595	DNA-templated transcription, initiation
HYU01_RS14570	COG1879	ABC-type sugar transport system periplasmic component
HYU01_RS14580	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYU01_RS14590	COG2390	Transcriptional regulator
HYU01_RS14595	COG1070	Carbohydrate kinase
HYU01_RS14625	COG2329	Antibiotic biosynthesis monooxygenase
HYU01_RS14645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HYU01_RS14655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HYU01_RS14660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYU01_RS14665	COG4187	Peptidase family M20/M25/M40
HYU01_RS14670	COG1414	Transcriptional regulator
HYU01_RS14675	COG0833	amino acid
HYU01_RS14680	COG1690	Belongs to the RtcB family
HYU01_RS14685	COG3239	Fatty acid desaturase
HYU01_RS14690	COG1785	Belongs to the alkaline phosphatase family
HYU01_RS14700	COG3655	Transcriptional regulator
HYU01_RS14715	COG4377	Putative membrane peptidase family (DUF2324)
HYU01_RS14725	COG3279	Response regulator of the LytR AlgR family
HYU01_RS14735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYU01_RS14740	COG0346	lactoylglutathione lyase activity
HYU01_RS14760	COG0714	Associated with various cellular activities
HYU01_RS14785	COG0463	Glycosyl transferase, family 2
HYU01_RS14810	COG0463	Glycosyl transferase, family 2
HYU01_RS14820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYU01_RS14825	COG0753	catalase activity
HYU01_RS14835	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYU01_RS14860	COG0714	Associated with various cellular activities
HYU01_RS14870	COG0778	Nitroreductase
HYU01_RS14875	COG1846	Transcriptional regulator
HYU01_RS14910	COG1725	Transcriptional regulator
HYU01_RS14920	COG1136	(ABC) transporter
HYU01_RS14920	COG0577	efflux transmembrane transporter activity
HYU01_RS14945	COG2207	Transcriptional regulator
HYU01_RS14950	COG0456	acetyltransferase
HYU01_RS14970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYU01_RS14990	COG0642	Histidine kinase
HYU01_RS14995	COG0745	RESPONSE REGULATOR receiver
HYU01_RS15000	COG0596	Alpha beta hydrolase
HYU01_RS15030	COG0730	response to heat
HYU01_RS15040	COG0833	amino acid
HYU01_RS15050	COG4335	DNA alkylation repair
HYU01_RS15090	COG0768	penicillin binding
HYU01_RS15100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HYU01_RS15135	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HYU01_RS15140	COG1414	Transcriptional regulator
HYU01_RS15155	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYU01_RS15160	COG0640	Transcriptional regulator
HYU01_RS15170	COG1960	acyl-CoA dehydrogenase activity
HYU01_RS15190	COG3314	Sporulation integral membrane protein YlbJ
HYU01_RS15205	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HYU01_RS15220	COG3848	Pyruvate phosphate dikinase
HYU01_RS15220	COG0574	Belongs to the PEP-utilizing enzyme family
HYU01_RS15225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYU01_RS15240	COG5577	PFAM Coat F domain
HYU01_RS15245	COG3403	YqcI/YcgG family
HYU01_RS15250	COG1280	lysine exporter protein (LysE YggA)
HYU01_RS15285	COG1063	alcohol dehydrogenase
HYU01_RS15300	COG1027	Aspartate ammonia-lyase
HYU01_RS15305	COG0252	asparaginase activity
HYU01_RS15310	COG1396	sequence-specific DNA binding
HYU01_RS15320	COG0322	excinuclease ABC activity
HYU01_RS15325	COG0531	amino acid
HYU01_RS15330	COG1114	Component of the transport system for branched-chain amino acids
HYU01_RS15335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYU01_RS15345	COG0281	malic enzyme
HYU01_RS15360	COG0531	amino acid
HYU01_RS15365	COG0697	spore germination
HYU01_RS15370	COG0784	Response regulator, receiver
HYU01_RS15380	COG2066	Belongs to the glutaminase family
HYU01_RS15385	COG1115	amino acid carrier protein
HYU01_RS15410	COG0737	Belongs to the 5'-nucleotidase family
HYU01_RS15415	COG0753	catalase activity
HYU01_RS15420	COG2267	carboxylic ester hydrolase activity
HYU01_RS15425	COG1335	isochorismatase
HYU01_RS15445	COG0583	DNA-binding transcription factor activity
HYU01_RS15455	COG0598	Magnesium transport protein CorA
HYU01_RS15490	COG0415	Belongs to the DNA photolyase family
HYU01_RS15495	COG0288	reversible hydration of carbon dioxide
HYU01_RS15505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYU01_RS15510	COG5609	conserved protein (DUF2294)
HYU01_RS15520	COG1575	Belongs to the MenA family. Type 1 subfamily
HYU01_RS15525	COG2267	carboxylic ester hydrolase activity
HYU01_RS15530	COG0803	Belongs to the bacterial solute-binding protein 9 family
HYU01_RS15535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYU01_RS15540	COG1121	(ABC) transporter
HYU01_RS15570	COG0798	PFAM Bile acid sodium symporter
HYU01_RS15575	COG0346	lactoylglutathione lyase activity
HYU01_RS15580	COG0640	Transcriptional regulator
HYU01_RS15595	COG0443	Heat shock 70 kDa protein
HYU01_RS15610	COG1522	sequence-specific DNA binding
HYU01_RS15625	COG0346	lactoylglutathione lyase activity
HYU01_RS15645	COG2169	Transcriptional regulator
HYU01_RS15690	COG2814	Major facilitator Superfamily
HYU01_RS15715	COG0745	RESPONSE REGULATOR receiver
HYU01_RS15720	COG3850	Histidine kinase
HYU01_RS15720	COG5002	protein histidine kinase activity
HYU01_RS15750	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYU01_RS15775	COG1476	TRANSCRIPTIONal
HYU01_RS15790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYU01_RS15795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYU01_RS15805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYU01_RS15810	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HYU01_RS15825	COG1136	(ABC) transporter
HYU01_RS15830	COG0577	efflux transmembrane transporter activity
HYU01_RS15850	COG5002	protein histidine kinase activity
HYU01_RS15850	COG3850	Histidine kinase
HYU01_RS15860	COG2364	Membrane
HYU01_RS15865	COG1846	Transcriptional regulator
HYU01_RS15875	COG2808	Putative FMN-binding domain
HYU01_RS15880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYU01_RS15885	COG2271	Major facilitator Superfamily
HYU01_RS15890	COG1556	Lactate utilization protein
HYU01_RS15895	COG1139	Iron-sulfur cluster binding protein
HYU01_RS15905	COG0583	DNA-binding transcription factor activity
HYU01_RS15915	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYU01_RS15945	COG0673	inositol 2-dehydrogenase activity
HYU01_RS15950	COG0561	phosphatase activity
HYU01_RS15960	COG1609	Transcriptional regulator
HYU01_RS15965	COG0457	Tetratricopeptide repeat
HYU01_RS15985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYU01_RS16015	COG0534	Mate efflux family protein
HYU01_RS16030	COG2814	Major facilitator Superfamily
HYU01_RS16035	COG1309	transcriptional regulator
HYU01_RS16050	COG0814	amino acid
HYU01_RS16055	COG1760	l-serine dehydratase
HYU01_RS16070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HYU01_RS16075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HYU01_RS16090	COG1522	sequence-specific DNA binding
HYU01_RS16095	COG0531	amino acid
HYU01_RS16110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYU01_RS16130	COG1595	DNA-templated transcription, initiation
HYU01_RS16145	COG0662	Cupin 2, conserved barrel domain protein
HYU01_RS16155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYU01_RS16155	COG2207	Transcriptional regulator
HYU01_RS16210	COG0477	Major facilitator Superfamily
HYU01_RS16220	COG1846	Transcriptional regulator
HYU01_RS16225	COG2814	Major facilitator Superfamily
HYU01_RS16240	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HYU01_RS16245	COG1131	(ABC) transporter
HYU01_RS16265	COG2076	Multidrug Resistance protein
HYU01_RS16270	COG1309	transcriptional regulator
HYU01_RS16285	COG2031	fatty acid transporter
HYU01_RS16295	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYU01_RS16325	COG1122	ATPase activity
HYU01_RS16330	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HYU01_RS16345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HYU01_RS16350	COG1288	antiporter activity
HYU01_RS16355	COG2356	endonuclease I
HYU01_RS16370	COG3620	sequence-specific DNA binding
HYU01_RS16375	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYU01_RS16380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HYU01_RS16385	COG0124	histidyl-tRNA synthetase
HYU01_RS16400	COG1733	regulation of RNA biosynthetic process
HYU01_RS16405	COG0778	Nitroreductase
HYU01_RS16425	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS16435	COG1131	(ABC) transporter
HYU01_RS16460	COG1011	Hydrolase
HYU01_RS16470	COG2365	Tyrosine phosphatase family
HYU01_RS16495	COG0346	lactoylglutathione lyase activity
HYU01_RS16500	COG1940	carbohydrate kinase activity
HYU01_RS16505	COG0738	Major facilitator superfamily
HYU01_RS16510	COG0110	maltose O-acetyltransferase activity
HYU01_RS16520	COG1136	(ABC) transporter
HYU01_RS16520	COG0577	efflux transmembrane transporter activity
HYU01_RS16530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HYU01_RS16535	COG0628	permease
HYU01_RS16555	COG2226	methyltransferase
HYU01_RS16565	COG0477	Major facilitator Superfamily
HYU01_RS16595	COG1253	flavin adenine dinucleotide binding
HYU01_RS16600	COG0789	Transcriptional regulator
HYU01_RS16605	COG0697	spore germination
HYU01_RS16610	COG1357	PFAM Pentapeptide repeats (8 copies)
HYU01_RS16615	COG3813	Protein conserved in bacteria
HYU01_RS16620	COG2706	6-phosphogluconolactonase activity
HYU01_RS16625	COG1070	Carbohydrate kinase
HYU01_RS16635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYU01_RS16640	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HYU01_RS16650	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HYU01_RS16655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HYU01_RS16660	COG0604	alcohol dehydrogenase
HYU01_RS16665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYU01_RS16675	COG0604	alcohol dehydrogenase
HYU01_RS16675	COG3321	synthase
HYU01_RS16685	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS16710	COG0656	L-ascorbic acid biosynthetic process
HYU01_RS16715	COG2814	Major facilitator Superfamily
HYU01_RS16730	COG0346	lactoylglutathione lyase activity
HYU01_RS16735	COG0814	amino acid
HYU01_RS16760	COG1393	Belongs to the ArsC family
HYU01_RS16770	COG1733	regulation of RNA biosynthetic process
HYU01_RS16775	COG2188	Transcriptional regulator
HYU01_RS16780	COG0673	inositol 2-dehydrogenase activity
HYU01_RS16785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYU01_RS16790	COG1733	regulation of RNA biosynthetic process
HYU01_RS16795	COG1733	regulation of RNA biosynthetic process
HYU01_RS16810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYU01_RS16830	COG0384	phenazine biosynthesis protein PhzF
HYU01_RS16840	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS16850	COG0318	PFAM AMP-dependent synthetase and ligase
HYU01_RS16860	COG1733	regulation of RNA biosynthetic process
HYU01_RS16895	COG1191	sigma factor activity
HYU01_RS16910	COG1309	transcriptional regulator
HYU01_RS16930	COG3152	Membrane
HYU01_RS16955	COG1151	hydroxylamine reductase activity
HYU01_RS16965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYU01_RS16970	COG3409	Peptidoglycan-binding domain 1 protein
HYU01_RS16970	COG3757	hydrolase, family 25
HYU01_RS17005	COG2072	flavoprotein involved in K transport
HYU01_RS17040	COG0604	alcohol dehydrogenase
HYU01_RS17045	COG1113	amino acid transport
HYU01_RS17050	COG2814	Major facilitator Superfamily
HYU01_RS17085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYU01_RS17090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HYU01_RS17110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYU01_RS17120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYU01_RS17125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYU01_RS17130	COG3739	integral membrane protein
HYU01_RS17135	COG0384	phenazine biosynthesis protein PhzF
HYU01_RS17165	COG0583	DNA-binding transcription factor activity
HYU01_RS17185	COG1193	negative regulation of DNA recombination
HYU01_RS17200	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HYU01_RS17205	COG1164	Oligoendopeptidase f
HYU01_RS17210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYU01_RS17240	COG0584	glycerophosphoryl diester phosphodiesterase
HYU01_RS17265	COG0640	Transcriptional regulator
HYU01_RS17270	COG0604	alcohol dehydrogenase
HYU01_RS17290	COG2808	Putative FMN-binding domain
HYU01_RS17305	COG0385	Bile acid
HYU01_RS17310	COG0277	FAD linked oxidase domain protein
HYU01_RS17345	COG1216	Glycosyl transferase, family 2
HYU01_RS17350	COG1024	Enoyl-CoA hydratase
HYU01_RS17360	COG1285	pathogenesis
HYU01_RS17370	COG2514	catechol 2,3-dioxygenase activity
HYU01_RS17375	COG2720	vancomycin resistance protein
HYU01_RS17415	COG0716	FMN binding
HYU01_RS17445	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS17470	COG4145	pantothenate transmembrane transporter activity
HYU01_RS17480	COG1012	belongs to the aldehyde dehydrogenase family
HYU01_RS17485	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS17495	COG1657	PFAM Prenyltransferase squalene oxidase
HYU01_RS17500	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HYU01_RS17505	COG2962	Rard protein
HYU01_RS17510	COG3326	Membrane
HYU01_RS17525	COG0489	protein tyrosine kinase activity
HYU01_RS17535	COG0314	molybdopterin synthase activity
HYU01_RS17540	COG0303	'Molybdopterin
HYU01_RS17545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HYU01_RS17550	COG2116	formate transmembrane transporter activity
HYU01_RS17560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HYU01_RS17565	COG5609	conserved protein (DUF2294)
HYU01_RS17570	COG2427	Protein of unknown function (DUF1641)
HYU01_RS17575	COG3383	formate dehydrogenase (NAD+) activity
HYU01_RS17585	COG0697	spore germination
HYU01_RS17625	COG2226	methyltransferase
HYU01_RS17630	COG4166	transmembrane transport
HYU01_RS17635	COG4166	transmembrane transport
HYU01_RS17640	COG1301	dicarboxylic acid transport
HYU01_RS17645	COG1316	TRANSCRIPTIONal
HYU01_RS17655	COG1595	DNA-templated transcription, initiation
HYU01_RS17680	COG1131	(ABC) transporter
HYU01_RS17690	COG0673	inositol 2-dehydrogenase activity
HYU01_RS17695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYU01_RS17700	COG0187	DNA topoisomerase II activity
HYU01_RS17710	COG1832	CoA-binding protein
HYU01_RS17715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYU01_RS17720	COG0745	RESPONSE REGULATOR receiver
HYU01_RS17735	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYU01_RS17740	COG4841	protein insertion into membrane
HYU01_RS17745	COG0824	Thioesterase
HYU01_RS17775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYU01_RS17785	COG2274	protein secretion by the type I secretion system
HYU01_RS17790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HYU01_RS17820	COG2211	Major facilitator Superfamily
HYU01_RS17830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYU01_RS17845	COG0183	Belongs to the thiolase family
HYU01_RS17850	COG0318	PFAM AMP-dependent synthetase and ligase
HYU01_RS17855	COG1268	BioY protein
HYU01_RS17860	COG0318	PFAM AMP-dependent synthetase and ligase
HYU01_RS17905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYU01_RS17915	COG5002	protein histidine kinase activity
HYU01_RS17920	COG0400	carboxylic ester hydrolase activity
HYU01_RS17925	COG0346	lactoylglutathione lyase activity
HYU01_RS17930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYU01_RS17935	COG0069	glutamate synthase activity
HYU01_RS17940	COG1902	pentaerythritol trinitrate reductase activity
HYU01_RS17945	COG1329	Transcriptional regulator
HYU01_RS17950	COG0010	Belongs to the arginase family
HYU01_RS17975	COG2226	methyltransferase
HYU01_RS18030	COG4846	Membrane protein involved in cytochrome C biogenesis
HYU01_RS18035	COG0785	Cytochrome C biogenesis protein
HYU01_RS18045	COG0583	DNA-binding transcription factor activity
HYU01_RS18050	COG1380	Effector of murein hydrolase LrgA
HYU01_RS18055	COG1346	cytolysis
HYU01_RS18070	COG0730	response to heat
HYU01_RS18080	COG5632	N-Acetylmuramoyl-L-alanine amidase
HYU01_RS18080	COG3409	Peptidoglycan-binding domain 1 protein
HYU01_RS18095	COG1132	(ABC) transporter
HYU01_RS18100	COG1132	(ABC) transporter
HYU01_RS18135	COG3639	organic phosphonate transmembrane transporter activity
HYU01_RS18140	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HYU01_RS18155	COG0737	Belongs to the 5'-nucleotidase family
HYU01_RS18165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYU01_RS18185	COG1695	Transcriptional regulator
HYU01_RS18220	COG1388	LysM domain
HYU01_RS18220	COG3409	Peptidoglycan-binding domain 1 protein
HYU01_RS18220	COG5632	N-Acetylmuramoyl-L-alanine amidase
HYU01_RS18225	COG4824	toxin secretion phage lysis holin
HYU01_RS18385	COG1595	DNA-templated transcription, initiation
HYU01_RS18430	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HYU01_RS18510	COG1396	sequence-specific DNA binding
HYU01_RS18535	COG0174	glutamine synthetase
HYU01_RS18540	COG0789	Transcriptional regulator
HYU01_RS18545	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HYU01_RS18550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYU01_RS18555	COG2860	membrane
HYU01_RS18560	COG0464	growth
HYU01_RS18590	COG1388	LysM domain
HYU01_RS18590	COG3584	3D domain protein
HYU01_RS18595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYU01_RS18595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HYU01_RS18595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HYU01_RS18600	COG1105	Belongs to the carbohydrate kinase PfkB family
HYU01_RS18605	COG1349	DNA-binding transcription factor activity
HYU01_RS18615	COG2322	membrane
HYU01_RS18630	COG1113	amino acid transport
HYU01_RS18640	COG1408	metallophosphoesterase
HYU01_RS18645	COG2116	formate transmembrane transporter activity
HYU01_RS18655	COG2217	Heavy metal translocating P-type atpase
HYU01_RS18660	COG2608	mercury ion transmembrane transporter activity
HYU01_RS18665	COG1937	Protein conserved in bacteria
HYU01_RS18675	COG2819	hydrolase of the alpha beta superfamily
HYU01_RS18680	COG1120	ATPase activity
HYU01_RS18685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYU01_RS18690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYU01_RS18695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYU01_RS18710	COG2169	Transcriptional regulator
HYU01_RS18715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYU01_RS18720	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HYU01_RS18730	COG2364	Membrane
HYU01_RS18745	COG2267	carboxylic ester hydrolase activity
HYU01_RS18750	COG0346	lactoylglutathione lyase activity
HYU01_RS18755	COG5001	Diguanylate cyclase
HYU01_RS18755	COG3300	MHYT domain
HYU01_RS18775	COG1346	cytolysis
HYU01_RS18780	COG1380	Effector of murein hydrolase LrgA
HYU01_RS18785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYU01_RS18790	COG0596	Alpha beta hydrolase
HYU01_RS18790	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYU01_RS18795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYU01_RS18810	COG1404	Belongs to the peptidase S8 family
HYU01_RS18815	COG3773	Cell wall hydrolase
HYU01_RS18820	COG0562	UDP-galactopyranose mutase
HYU01_RS18830	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HYU01_RS18840	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HYU01_RS18865	COG1131	(ABC) transporter
HYU01_RS18885	COG4550	Control of competence regulator ComK, YlbF/YmcA
HYU01_RS18890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYU01_RS18895	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYU01_RS18900	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYU01_RS18900	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYU01_RS18910	COG2359	stage V sporulation protein S
HYU01_RS18915	COG1692	metallophosphoesterase
HYU01_RS18940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYU01_RS18945	COG1426	Protein conserved in bacteria
HYU01_RS18960	COG0300	oxidoreductase activity
HYU01_RS18965	COG0612	Peptidase, M16
HYU01_RS18970	COG0612	Peptidase, M16
HYU01_RS18975	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYU01_RS18980	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYU01_RS18985	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYU01_RS18990	COG3845	ABC transporter
HYU01_RS18995	COG1744	ABC transporter substrate-binding protein PnrA-like
HYU01_RS19000	COG2188	Transcriptional regulator
HYU01_RS19005	COG1674	ftsk spoiiie
HYU01_RS19015	COG0740	serine-type endopeptidase activity
HYU01_RS19020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYU01_RS19035	COG0527	aspartate kinase activity
HYU01_RS19040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYU01_RS19045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYU01_RS19050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYU01_RS19055	COG1873	PFAM PRC-barrel domain
HYU01_RS19060	COG0612	Peptidase, M16
HYU01_RS19065	COG0726	polysaccharide deacetylase
HYU01_RS19080	COG0196	riboflavin kinase activity
HYU01_RS19085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYU01_RS19095	COG1550	Protein conserved in bacteria
HYU01_RS19105	COG1358	cellular component organization or biogenesis
HYU01_RS19110	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HYU01_RS19115	COG0195	Participates in both transcription termination and antitermination
HYU01_RS19135	COG0750	zinc metalloprotease
HYU01_RS19145	COG4589	Belongs to the CDS family
HYU01_RS19160	COG0528	UMP kinase activity
HYU01_RS19190	COG4974	Belongs to the 'phage' integrase family
HYU01_RS19200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYU01_RS19210	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYU01_RS19250	COG1837	Belongs to the UPF0109 family
HYU01_RS19260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYU01_RS19270	COG0552	protein localization to endoplasmic reticulum
HYU01_RS19275	COG1196	nuclear chromosome segregation
HYU01_RS19285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYU01_RS19290	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS19295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYU01_RS19310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYU01_RS19315	COG1461	Dihydroxyacetone kinase
HYU01_RS19320	COG1302	Protein conserved in bacteria
HYU01_RS19335	COG1564	THIamine pyrophosphokinase
HYU01_RS19340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYU01_RS19345	COG1162	GTPase activity
HYU01_RS19350	COG0515	serine threonine protein kinase
HYU01_RS19350	COG2815	serine threonine protein kinase
HYU01_RS19355	COG0631	protein serine/threonine phosphatase activity
HYU01_RS19365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYU01_RS19365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYU01_RS19375	COG0242	peptide deformylase activity
HYU01_RS19380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYU01_RS19385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYU01_RS19405	COG1561	YicC-like family, N-terminal region
HYU01_RS19410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HYU01_RS19420	COG0006	proline dipeptidase activity
HYU01_RS19435	COG3069	C4-dicarboxylate transmembrane transporter activity
HYU01_RS19500	COG0564	pseudouridine synthase activity
HYU01_RS19520	COG3599	regulation of cell shape
HYU01_RS19525	COG2302	S4 RNA-binding domain
HYU01_RS19530	COG0762	integral membrane protein
HYU01_RS19540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYU01_RS19545	COG1496	oxidoreductase activity
HYU01_RS19550	COG1873	PFAM PRC-barrel domain
HYU01_RS19555	COG1191	sigma factor activity
HYU01_RS19560	COG1191	sigma factor activity
HYU01_RS19570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYU01_RS19575	COG0849	cell division
HYU01_RS19580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HYU01_RS19585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYU01_RS19595	COG0772	Belongs to the SEDS family
HYU01_RS19610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYU01_RS19615	COG0768	penicillin binding
HYU01_RS19620	COG0768	penicillin binding
HYU01_RS19625	COG4839	cell division protein FtsL
HYU01_RS19640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HYU01_RS19655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYU01_RS19660	COG1399	metal-binding, possibly nucleic acid-binding protein
HYU01_RS19710	COG4824	toxin secretion phage lysis holin
HYU01_RS19805	COG1802	Transcriptional regulator
HYU01_RS19805	COG4626	Terminase
HYU01_RS19830	COG0582	viral genome integration into host DNA
HYU01_RS19900	COG0756	dUTP diphosphatase activity
HYU01_RS19910	COG1191	sigma factor activity
HYU01_RS19935	COG1484	DNA-dependent DNA replication
HYU01_RS19965	COG1396	sequence-specific DNA binding
HYU01_RS19975	COG1396	sequence-specific DNA binding
HYU01_RS19990	COG0582	viral genome integration into host DNA
HYU01_RS20000	COG3480	Lon protease (S16) C-terminal proteolytic domain
HYU01_RS20005	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYU01_RS20010	COG3314	Sporulation integral membrane protein YlbJ
HYU01_RS20020	COG0742	ribosomal rna small subunit methyltransferase
HYU01_RS20035	COG3679	Belongs to the UPF0342 family
HYU01_RS20040	COG0406	alpha-ribazole phosphatase activity
HYU01_RS20055	COG2340	Cysteine-rich secretory protein family
HYU01_RS20070	COG3336	cytochrome c oxidase
HYU01_RS20105	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HYU01_RS20110	COG0772	Belongs to the SEDS family
HYU01_RS20120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HYU01_RS20125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HYU01_RS20135	COG4896	Protein conserved in bacteria
HYU01_RS20150	COG1217	gtp-binding protein TYPA
HYU01_RS20160	COG0483	inositol monophosphate 1-phosphatase activity
HYU01_RS20180	COG1982	Orn Lys Arg decarboxylase major
HYU01_RS20230	COG0022	dehydrogenase e1 component
HYU01_RS20235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYU01_RS20245	COG0242	peptide deformylase activity
HYU01_RS20250	COG0561	phosphatase activity
HYU01_RS20260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYU01_RS20265	COG0569	domain protein
HYU01_RS20285	COG0583	DNA-binding transcription factor activity
HYU01_RS20290	COG0517	IMP dehydrogenase activity
HYU01_RS20300	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HYU01_RS20310	COG4703	Protein of unknown function (DUF1797)
HYU01_RS20325	COG2200	EAL domain
HYU01_RS20330	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS20335	COG1408	metallophosphoesterase
HYU01_RS20385	COG2814	Major facilitator Superfamily
HYU01_RS20410	COG3209	COG3209 Rhs family protein
HYU01_RS20420	COG2205	protein histidine kinase activity
HYU01_RS20430	COG0436	Aminotransferase
HYU01_RS20435	COG1609	Transcriptional regulator
HYU01_RS20440	COG3833	ABC-type maltose transport systems, permease component
HYU01_RS20445	COG1175	transmembrane transport
HYU01_RS20450	COG2182	Extracellular solute-binding protein
HYU01_RS20460	COG0366	Alpha amylase catalytic
HYU01_RS20465	COG3842	ATPase activity
HYU01_RS20505	COG0183	Belongs to the thiolase family
HYU01_RS20545	COG1695	Transcriptional regulator
HYU01_RS20550	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS20560	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HYU01_RS20570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYU01_RS20575	COG0436	Aminotransferase
HYU01_RS20595	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HYU01_RS20615	COG2199	diguanylate cyclase activity
HYU01_RS20620	COG0778	Nitroreductase
HYU01_RS20645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYU01_RS20645	COG1263	PTS System
HYU01_RS20645	COG2190	(PTS) system
HYU01_RS20650	COG3711	transcriptional antiterminator
HYU01_RS20660	COG2188	Transcriptional regulator
HYU01_RS20670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HYU01_RS20700	COG1547	Domain of unknown function (DUF309)
HYU01_RS20705	COG0456	acetyltransferase
HYU01_RS20715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYU01_RS20720	COG4086	secreted protein
HYU01_RS20725	COG0561	phosphatase activity
HYU01_RS20730	COG0697	spore germination
HYU01_RS20745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYU01_RS20770	COG0733	neurotransmitter:sodium symporter activity
HYU01_RS20790	COG1686	Belongs to the peptidase S11 family
HYU01_RS20795	COG1725	Transcriptional regulator
HYU01_RS20800	COG1131	(ABC) transporter
HYU01_RS20820	COG1846	Transcriptional regulator
HYU01_RS20835	COG0598	Magnesium transport protein CorA
HYU01_RS20860	COG4974	Belongs to the 'phage' integrase family
HYU01_RS20870	COG0735	belongs to the Fur family
HYU01_RS20875	COG1300	Membrane
HYU01_RS20895	COG0667	Aldo Keto reductase
HYU01_RS20900	COG0656	L-ascorbic acid biosynthetic process
HYU01_RS20905	COG0456	acetyltransferase
HYU01_RS20905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HYU01_RS20915	COG4085	toxin activity
HYU01_RS20915	COG1525	nuclease
HYU01_RS20915	COG0737	Belongs to the 5'-nucleotidase family
HYU01_RS20925	COG0596	Alpha beta hydrolase
HYU01_RS20930	COG2056	Na+-H+ antiporter family
HYU01_RS20935	COG1609	Transcriptional regulator
HYU01_RS20940	COG0456	acetyltransferase
HYU01_RS20945	COG1073	alpha beta
HYU01_RS20960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYU01_RS20960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYU01_RS20965	COG0307	riboflavin synthase, alpha
HYU01_RS20990	COG4106	trans-aconitate 2-methyltransferase activity
HYU01_RS20995	COG1073	alpha beta
HYU01_RS20995	COG2226	methyltransferase
HYU01_RS21010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYU01_RS21020	COG1757	Na H antiporter
HYU01_RS21025	COG0737	Belongs to the 5'-nucleotidase family
HYU01_RS21035	COG1522	sequence-specific DNA binding
HYU01_RS21055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYU01_RS21065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HYU01_RS21080	COG0300	oxidoreductase activity
HYU01_RS21085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYU01_RS21090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYU01_RS21095	COG1760	l-serine dehydratase
HYU01_RS21100	COG1760	l-serine dehydratase
HYU01_RS21120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYU01_RS21130	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYU01_RS21135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYU01_RS21150	COG1376	ErfK ybiS ycfS ynhG family protein
HYU01_RS21155	COG4129	membrane
HYU01_RS21160	COG1126	abc transporter atp-binding protein
HYU01_RS21165	COG0765	amino acid transport
HYU01_RS21170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYU01_RS21190	COG2816	NAD+ diphosphatase activity
HYU01_RS21195	COG0772	Belongs to the SEDS family
HYU01_RS21205	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYU01_RS21210	COG0022	dehydrogenase e1 component
HYU01_RS21215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYU01_RS21220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYU01_RS21235	COG0280	phosphate acetyltransferase
HYU01_RS21245	COG3829	transcription factor binding
HYU01_RS21245	COG3290	protein histidine kinase activity
HYU01_RS21255	COG0584	glycerophosphoryl diester phosphodiesterase
HYU01_RS21260	COG3093	addiction module antidote protein HigA
HYU01_RS21270	COG0745	RESPONSE REGULATOR receiver
HYU01_RS21275	COG0750	zinc metalloprotease
HYU01_RS21280	COG0497	DNA recombination
HYU01_RS21290	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HYU01_RS21300	COG0142	geranyltranstransferase activity
HYU01_RS21325	COG1302	Protein conserved in bacteria
HYU01_RS21330	COG0439	Biotin carboxylase
HYU01_RS21335	COG0511	ligase activity, forming carbon-carbon bonds
HYU01_RS21380	COG3854	ATPases associated with a variety of cellular activities
HYU01_RS21405	COG0006	proline dipeptidase activity
HYU01_RS21420	COG3872	metal-dependent enzyme
HYU01_RS21430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYU01_RS21450	COG0095	Lipoate-protein ligase
HYU01_RS21455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYU01_RS21460	COG1609	Transcriptional regulator
HYU01_RS21470	COG2076	Multidrug Resistance protein
HYU01_RS21475	COG2076	Multidrug Resistance protein
HYU01_RS21515	COG1131	(ABC) transporter
HYU01_RS21520	COG1725	Transcriptional regulator
HYU01_RS21550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYU01_RS21605	COG4970	Tfp pilus assembly protein FimT
HYU01_RS21615	COG1459	type II secretion system
HYU01_RS21620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYU01_RS21670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYU01_RS21680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HYU01_RS21680	COG0646	methionine synthase
HYU01_RS21690	COG0626	cystathionine gamma-synthase activity
HYU01_RS21695	COG0626	cystathionine gamma-synthase activity
HYU01_RS21720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYU01_RS21730	COG1940	carbohydrate kinase activity
HYU01_RS21735	COG4483	Protein conserved in bacteria
HYU01_RS21740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYU01_RS21745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYU01_RS21750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYU01_RS21755	COG0704	Plays a role in the regulation of phosphate uptake
HYU01_RS21765	COG0581	inorganic phosphate transmembrane transporter activity
HYU01_RS21770	COG0573	inorganic phosphate transmembrane transporter activity
HYU01_RS21775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HYU01_RS21780	COG0768	penicillin binding
HYU01_RS21785	COG0477	Major facilitator Superfamily
HYU01_RS21790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYU01_RS21815	COG0735	belongs to the Fur family
HYU01_RS21820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYU01_RS21825	COG1121	(ABC) transporter
HYU01_RS21830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYU01_RS21860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYU01_RS21865	COG2384	SAM-dependent methyltransferase
HYU01_RS21870	COG2010	Cytochrome c
HYU01_RS21875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYU01_RS21880	COG0358	DNA primase activity
HYU01_RS21900	COG0517	IMP dehydrogenase activity
HYU01_RS21915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYU01_RS21920	COG0295	cytidine deaminase activity
HYU01_RS21925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HYU01_RS21935	COG1480	7TM receptor with intracellular HD hydrolase
HYU01_RS21940	COG1702	phosphate starvation-inducible protein PhoH
HYU01_RS21960	COG1610	YqeY-like protein
HYU01_RS21965	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HYU01_RS21970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYU01_RS21975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYU01_RS22005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYU01_RS22010	COG1733	regulation of RNA biosynthetic process
HYU01_RS22035	COG1466	dna polymerase III delta subunit
HYU01_RS22050	COG2131	deaminase
HYU01_RS22055	COG1596	polysaccharide export
HYU01_RS22055	COG1555	photosystem II stabilization
HYU01_RS22060	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYU01_RS22065	COG2226	methyltransferase
HYU01_RS22070	COG0799	negative regulation of ribosome biogenesis
HYU01_RS22075	COG1713	HD superfamily hydrolase involved in NAD metabolism
HYU01_RS22085	COG1534	Rna-binding protein
HYU01_RS22095	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HYU01_RS22100	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HYU01_RS22125	COG1595	DNA-templated transcription, initiation
HYU01_RS22135	COG0778	Nitroreductase
HYU01_RS22140	COG2357	RelA SpoT domain protein
HYU01_RS22150	COG1785	Belongs to the alkaline phosphatase family
HYU01_RS22160	COG2267	carboxylic ester hydrolase activity
HYU01_RS22195	COG1404	Belongs to the peptidase S8 family
HYU01_RS22200	COG3186	Phenylalanine-4-hydroxylase
HYU01_RS22210	COG2514	catechol 2,3-dioxygenase activity
HYU01_RS22215	COG2259	Doxx family
HYU01_RS22255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYU01_RS22265	COG1012	belongs to the aldehyde dehydrogenase family
HYU01_RS22265	COG1454	alcohol dehydrogenase
HYU01_RS22270	COG0626	cystathionine gamma-synthase activity
HYU01_RS22275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYU01_RS22300	COG0768	penicillin binding
HYU01_RS22315	COG0826	peptidase U32
HYU01_RS22320	COG0826	peptidase U32
HYU01_RS22325	COG4122	O-methyltransferase activity
HYU01_RS22330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYU01_RS22350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYU01_RS22360	COG0628	permease
HYU01_RS22380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYU01_RS22390	COG0482	sulfurtransferase activity
HYU01_RS22395	COG1104	cysteine desulfurase activity
HYU01_RS22400	COG1959	2 iron, 2 sulfur cluster binding
HYU01_RS22405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYU01_RS22415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYU01_RS22440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYU01_RS22450	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYU01_RS22450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYU01_RS22455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HYU01_RS22460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYU01_RS22460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYU01_RS22470	COG2244	polysaccharide biosynthetic process
HYU01_RS22475	COG2323	membrane
HYU01_RS22485	COG1862	Preprotein translocase
HYU01_RS22515	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HYU01_RS22525	COG0697	spore germination
HYU01_RS22530	COG0697	spore germination
HYU01_RS22535	COG0640	Transcriptional regulator
HYU01_RS22560	COG0157	Belongs to the NadC ModD family
HYU01_RS22565	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HYU01_RS22570	COG1104	cysteine desulfurase activity
HYU01_RS22575	COG1827	regulation of RNA biosynthetic process
HYU01_RS22580	COG2258	MOSC domain
HYU01_RS22585	COG0077	Prephenate dehydratase
HYU01_RS22590	COG0577	efflux transmembrane transporter activity
HYU01_RS22595	COG0577	efflux transmembrane transporter activity
HYU01_RS22600	COG1136	(ABC) transporter
HYU01_RS22605	COG5002	protein histidine kinase activity
HYU01_RS22615	COG0745	RESPONSE REGULATOR receiver
HYU01_RS22620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYU01_RS22625	COG3290	protein histidine kinase activity
HYU01_RS22635	COG2868	ribosomal protein
HYU01_RS22645	COG1530	ribonuclease E activity
HYU01_RS22650	COG1994	Peptidase M50
HYU01_RS22655	COG0739	heme binding
HYU01_RS22660	COG2894	cell division
HYU01_RS22680	COG1077	Cell shape determining protein MreB Mrl
HYU01_RS22700	COG0285	dihydrofolate synthase activity
HYU01_RS22705	COG0525	valine-tRNA ligase activity
HYU01_RS22715	COG1388	LysM domain
HYU01_RS22725	COG0113	porphobilinogen synthase activity
HYU01_RS22730	COG1587	Uroporphyrinogen-III synthase
HYU01_RS22740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYU01_RS22750	COG1846	Transcriptional regulator
HYU01_RS22755	COG1764	response to oxidative stress
HYU01_RS22770	COG1067	ATP-dependent peptidase activity
HYU01_RS22770	COG0470	DNA polymerase III
HYU01_RS22820	COG0622	Phosphoesterase
HYU01_RS22835	COG5401	PFAM Sporulation and spore germination
HYU01_RS22855	COG1309	transcriptional regulator
HYU01_RS22870	COG2197	response regulator
HYU01_RS22875	COG2233	PERMEase
HYU01_RS22885	COG0402	S-adenosylhomocysteine deaminase activity
HYU01_RS22890	COG0402	S-adenosylhomocysteine deaminase activity
HYU01_RS22900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYU01_RS22910	COG0444	Belongs to the ABC transporter superfamily
HYU01_RS22915	COG4608	Belongs to the ABC transporter superfamily
HYU01_RS22920	COG3275	phosphorelay sensor kinase activity
HYU01_RS22925	COG3279	Response regulator of the LytR AlgR family
HYU01_RS22940	COG1983	PspC domain protein
HYU01_RS22945	COG1396	sequence-specific DNA binding
HYU01_RS22950	COG0697	spore germination
HYU01_RS22960	COG1959	2 iron, 2 sulfur cluster binding
HYU01_RS22965	COG1668	transmembrane transport
HYU01_RS22975	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HYU01_RS22985	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HYU01_RS22990	COG1876	peptidase activity
HYU01_RS22995	COG0824	Thioesterase
HYU01_RS23000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYU01_RS23005	COG1053	succinate dehydrogenase
HYU01_RS23010	COG2009	succinate dehydrogenase
HYU01_RS23015	COG1719	4-vinyl reductase, 4VR
HYU01_RS23025	COG3118	belongs to the thioredoxin family
HYU01_RS23030	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYU01_RS23035	COG2086	electron transfer activity
HYU01_RS23040	COG1024	Enoyl-CoA hydratase
HYU01_RS23045	COG1309	transcriptional regulator
HYU01_RS23050	COG0318	PFAM AMP-dependent synthetase and ligase
HYU01_RS23070	COG2318	DinB family
HYU01_RS23100	COG1131	(ABC) transporter
HYU01_RS23105	COG2205	protein histidine kinase activity
HYU01_RS23110	COG0745	RESPONSE REGULATOR receiver
HYU01_RS23120	COG4895	conserved protein (DUF2196)
HYU01_RS23125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HYU01_RS23140	COG4509	Sortase family
HYU01_RS23145	COG1120	ATPase activity
HYU01_RS23160	COG5386	Cell surface protein
HYU01_RS23170	COG5386	Cell surface protein
HYU01_RS23175	COG1114	Component of the transport system for branched-chain amino acids
HYU01_RS23180	COG1187	pseudouridine synthase activity
HYU01_RS23195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYU01_RS23195	COG1796	DNA polymerase
HYU01_RS23200	COG1286	toxin biosynthetic process
HYU01_RS23245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYU01_RS23255	COG1418	mRNA catabolic process
HYU01_RS23280	COG2814	Major facilitator Superfamily
HYU01_RS23285	COG1566	PFAM secretion protein HlyD family protein
HYU01_RS23290	COG1309	transcriptional regulator
HYU01_RS23295	COG1363	Peptidase, m42
HYU01_RS23320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYU01_RS23330	COG1484	DNA-dependent DNA replication
HYU01_RS23335	COG3611	Membrane attachment protein
HYU01_RS23345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYU01_RS23350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYU01_RS23355	COG0237	dephospho-CoA kinase activity
HYU01_RS23360	COG1971	Probably functions as a manganese efflux pump
HYU01_RS23370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYU01_RS23370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYU01_RS23375	COG5002	protein histidine kinase activity
HYU01_RS23380	COG0745	RESPONSE REGULATOR receiver
HYU01_RS23400	COG0538	isocitrate dehydrogenase activity
HYU01_RS23405	COG0372	Belongs to the citrate synthase family
HYU01_RS23420	COG0628	permease
HYU01_RS23425	COG3030	protein affecting phage T7 exclusion by the F plasmid
HYU01_RS23450	COG1725	Transcriptional regulator
HYU01_RS23455	COG0281	malic enzyme
HYU01_RS23460	COG0587	DNA-directed DNA polymerase activity
HYU01_RS23475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYU01_RS23495	COG4109	DRTGG domain
HYU01_RS23510	COG0006	proline dipeptidase activity
HYU01_RS23545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYU01_RS23550	COG0662	Cupin 2, conserved barrel domain protein
HYU01_RS23560	COG1476	TRANSCRIPTIONal
HYU01_RS23575	COG1028	Short-chain dehydrogenase reductase Sdr
HYU01_RS23580	COG0589	response to stress
HYU01_RS23620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYU01_RS23640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYU01_RS23645	COG0827	DNA restriction-modification system
HYU01_RS23650	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HYU01_RS23655	COG3874	Sporulation protein YtfJ
HYU01_RS23670	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HYU01_RS23680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYU01_RS23695	COG1104	cysteine desulfurase activity
HYU01_RS23705	COG0583	DNA-binding transcription factor activity
HYU01_RS23710	COG0697	spore germination
HYU01_RS23720	COG1956	GAF domain-containing protein
HYU01_RS23725	COG0626	cystathionine gamma-synthase activity
HYU01_RS23755	COG1595	DNA-templated transcription, initiation
HYU01_RS23765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYU01_RS23770	COG0454	-acetyltransferase
HYU01_RS23775	COG0517	IMP dehydrogenase activity
HYU01_RS23780	COG0123	including yeast histone deacetylase and acetoin utilization protein
HYU01_RS23790	COG0745	RESPONSE REGULATOR receiver
HYU01_RS23800	COG0666	response to abiotic stimulus
HYU01_RS23835	COG1609	Transcriptional regulator
HYU01_RS23845	COG4851	CamS sex pheromone cAM373 precursor
HYU01_RS23850	COG3118	belongs to the thioredoxin family
HYU01_RS23860	COG2309	aminopeptidase activity
HYU01_RS23880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYU01_RS23895	COG1674	ftsk spoiiie
HYU01_RS23905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYU01_RS23910	COG4848	Belongs to the UPF0354 family
HYU01_RS23915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYU01_RS23920	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HYU01_RS23925	COG1363	Peptidase, m42
HYU01_RS23935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYU01_RS23950	COG0510	thiamine kinase activity
HYU01_RS23955	COG1523	belongs to the glycosyl hydrolase 13 family
HYU01_RS23970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYU01_RS23975	COG1349	DNA-binding transcription factor activity
HYU01_RS23980	COG1187	pseudouridine synthase activity
HYU01_RS23985	COG2244	polysaccharide biosynthetic process
HYU01_RS23990	COG2081	HI0933 family
HYU01_RS23995	COG2814	Major facilitator Superfamily
HYU01_RS24005	COG3832	glyoxalase III activity
HYU01_RS24025	COG1329	Transcriptional regulator
HYU01_RS24035	COG4975	Glucose uptake
HYU01_RS24050	COG0314	molybdopterin synthase activity
HYU01_RS24055	COG1763	Mo-molybdopterin cofactor biosynthetic process
HYU01_RS24060	COG0303	'Molybdopterin
HYU01_RS24070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HYU01_RS24075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYU01_RS24095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYU01_RS24105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYU01_RS24150	COG2814	Major facilitator Superfamily
HYU01_RS24155	COG0475	glutathione-regulated potassium exporter activity
HYU01_RS24160	COG0490	domain, Protein
HYU01_RS24165	COG0582	viral genome integration into host DNA
HYU01_RS24175	COG1136	(ABC) transporter
HYU01_RS24195	COG1242	4 iron, 4 sulfur cluster binding
HYU01_RS24200	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HYU01_RS24205	COG1131	(ABC) transporter
HYU01_RS24215	COG1794	racemase activity, acting on amino acids and derivatives
HYU01_RS24235	COG2267	carboxylic ester hydrolase activity
HYU01_RS24240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HYU01_RS24245	COG0671	phosphoesterase, PA-phosphatase related
HYU01_RS24250	COG0438	transferase activity, transferring glycosyl groups
HYU01_RS24260	COG0521	Mo-molybdopterin cofactor biosynthetic process
HYU01_RS24315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYU01_RS24320	COG5002	protein histidine kinase activity
HYU01_RS24325	COG4191	Histidine kinase
HYU01_RS24330	COG2267	carboxylic ester hydrolase activity
HYU01_RS24350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYU01_RS24355	COG1116	anion transmembrane transporter activity
HYU01_RS24360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYU01_RS24385	COG0494	nUDIX hydrolase
HYU01_RS24415	COG0288	reversible hydration of carbon dioxide
HYU01_RS24420	COG1271	oxidase subunit
HYU01_RS24425	COG1294	oxidase, subunit
HYU01_RS24445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYU01_RS24470	COG1842	Phage shock protein A
HYU01_RS24505	COG5002	protein histidine kinase activity
HYU01_RS24510	COG0745	RESPONSE REGULATOR receiver
HYU01_RS24535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYU01_RS24540	COG1597	lipid kinase activity
HYU01_RS24575	COG0586	Pfam SNARE associated Golgi protein
HYU01_RS24585	COG0577	efflux transmembrane transporter activity
HYU01_RS24590	COG1136	(ABC) transporter
HYU01_RS24595	COG3708	Transcriptional regulator
HYU01_RS24595	COG2207	Transcriptional regulator
HYU01_RS24600	COG0745	RESPONSE REGULATOR receiver
HYU01_RS24605	COG2205	protein histidine kinase activity
HYU01_RS24610	COG0577	efflux transmembrane transporter activity
HYU01_RS24615	COG0577	efflux transmembrane transporter activity
HYU01_RS24620	COG1136	(ABC) transporter
HYU01_RS24640	COG2188	Transcriptional regulator
HYU01_RS24660	COG3964	amidohydrolase
HYU01_RS24690	COG4948	Mandelate Racemase Muconate Lactonizing
HYU01_RS24700	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HYU01_RS24705	COG0596	Alpha beta hydrolase
HYU01_RS24710	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HYU01_RS24715	COG1169	isochorismate synthase
HYU01_RS24720	COG1575	Belongs to the MenA family. Type 1 subfamily
HYU01_RS24725	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HYU01_RS24750	COG0058	SHG alpha-glucan phosphorylase activity
HYU01_RS24755	COG0297	glycogen (starch) synthase activity
HYU01_RS24760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYU01_RS24870	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYU01_RS24905	COG1285	pathogenesis
HYU01_RS24910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYU01_RS24920	COG0166	Belongs to the GPI family
HYU01_RS24930	COG2155	Conserved Protein
HYU01_RS24935	COG1098	S1 RNA binding domain
HYU01_RS24940	COG0436	Aminotransferase
HYU01_RS24945	COG1522	sequence-specific DNA binding
HYU01_RS24950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYU01_RS24955	COG2267	carboxylic ester hydrolase activity
HYU01_RS24965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYU01_RS24985	COG5018	Exonuclease
HYU01_RS24990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HYU01_RS25010	COG2050	protein possibly involved in aromatic compounds catabolism
HYU01_RS25020	COG1268	BioY protein
HYU01_RS25030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYU01_RS25035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYU01_RS25050	COG3584	3D domain protein
HYU01_RS25065	COG1252	NADH dehydrogenase
HYU01_RS25080	COG3708	Transcriptional regulator
HYU01_RS25095	COG1683	Conserved Protein
HYU01_RS25115	COG0316	Belongs to the HesB IscA family
HYU01_RS25130	COG1252	NADH dehydrogenase
HYU01_RS25140	COG2274	protein secretion by the type I secretion system
HYU01_RS25145	COG0390	transport system, permease component
HYU01_RS25150	COG2824	Alkylphosphonate utilization operon protein PhnA
HYU01_RS25190	COG4837	Protein of unknown function (DUF1462)
HYU01_RS25195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HYU01_RS25205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HYU01_RS25210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HYU01_RS25225	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYU01_RS25230	COG0647	UMP catabolic process
HYU01_RS25240	COG2445	Protein of unknown function DUF86
HYU01_RS25245	COG1494	fructose-1,6-bisphosphatase
HYU01_RS25265	COG4470	Protein conserved in bacteria
HYU01_RS25275	COG0789	Transcriptional regulator
HYU01_RS25280	COG4377	Putative membrane peptidase family (DUF2324)
HYU01_RS25305	COG0739	heme binding
HYU01_RS25315	COG3377	Domain of unknown function (DUF1805)
HYU01_RS25320	COG0737	Belongs to the 5'-nucleotidase family
HYU01_RS25330	COG1695	Transcriptional regulator
HYU01_RS25345	COG0719	Fe-S assembly protein
HYU01_RS25350	COG0822	iron-sulfur transferase activity
HYU01_RS25355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYU01_RS25360	COG0719	Fe-S assembly protein
HYU01_RS25365	COG0396	ATPase activity
HYU01_RS25370	COG1464	Belongs to the NlpA lipoprotein family
HYU01_RS25375	COG1464	Belongs to the NlpA lipoprotein family
HYU01_RS25380	COG2011	ABC-type metal ion transport system permease component
HYU01_RS25385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYU01_RS25400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYU01_RS25405	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HYU01_RS25415	COG1393	Belongs to the ArsC family
HYU01_RS25465	COG0039	L-malate dehydrogenase activity
HYU01_RS25490	COG1309	transcriptional regulator
HYU01_RS25495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYU01_RS25500	COG1960	acyl-CoA dehydrogenase activity
HYU01_RS25510	COG0183	Belongs to the thiolase family
HYU01_RS25515	COG1024	Enoyl-CoA hydratase
HYU01_RS25515	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYU01_RS25525	COG1686	Belongs to the peptidase S11 family
HYU01_RS25540	COG0011	TIGRFAM Protein of
HYU01_RS25545	COG0840	transmembrane signaling receptor activity
HYU01_RS25565	COG2814	Major facilitator Superfamily
HYU01_RS25570	COG0531	amino acid
HYU01_RS25580	COG0706	membrane insertase activity
HYU01_RS25590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYU01_RS25625	COG0586	Pfam SNARE associated Golgi protein
HYU01_RS25635	COG1376	ErfK ybiS ycfS ynhG family protein
HYU01_RS25640	COG0745	RESPONSE REGULATOR receiver
HYU01_RS25645	COG5002	protein histidine kinase activity
HYU01_RS25670	COG2151	metal-sulfur cluster biosynthetic enzyme
HYU01_RS25675	COG3227	Zinc metalloprotease (Elastase)
HYU01_RS25680	COG1741	Belongs to the pirin family
HYU01_RS25695	COG0475	glutathione-regulated potassium exporter activity
HYU01_RS25700	COG0490	domain, Protein
HYU01_RS25710	COG1115	amino acid carrier protein
HYU01_RS25715	COG0783	Belongs to the Dps family
HYU01_RS25730	COG1611	Belongs to the LOG family
HYU01_RS25745	COG2311	Membrane
HYU01_RS25755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HYU01_RS25760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HYU01_RS25765	COG1115	amino acid carrier protein
HYU01_RS25770	COG1115	amino acid carrier protein
HYU01_RS25775	COG2910	NAD(P)H-binding
HYU01_RS25790	COG0656	L-ascorbic acid biosynthetic process
HYU01_RS25795	COG2814	Major facilitator Superfamily
HYU01_RS25800	COG1733	regulation of RNA biosynthetic process
HYU01_RS25810	COG1252	NADH dehydrogenase
HYU01_RS25815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYU01_RS25820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYU01_RS25830	COG3290	protein histidine kinase activity
HYU01_RS25830	COG0840	transmembrane signaling receptor activity
HYU01_RS25840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HYU01_RS25845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HYU01_RS25860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYU01_RS25910	COG0557	exoribonuclease II activity
HYU01_RS25915	COG1647	Serine aminopeptidase, S33
HYU01_RS25920	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYU01_RS25925	COG1346	cytolysis
HYU01_RS26025	COG4695	Portal protein
HYU01_RS26050	COG4974	Belongs to the 'phage' integrase family
HYU01_RS26065	COG0149	triose-phosphate isomerase activity
HYU01_RS26075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYU01_RS26090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HYU01_RS26115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYU01_RS26130	COG2323	membrane
HYU01_RS26135	COG0740	serine-type endopeptidase activity
HYU01_RS26140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYU01_RS26150	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HYU01_RS26160	COG1051	belongs to the nudix hydrolase family
HYU01_RS26170	COG0492	ferredoxin-NADP+ reductase activity
HYU01_RS26175	COG0457	Tetratricopeptide repeat
HYU01_RS26180	COG0110	maltose O-acetyltransferase activity
HYU01_RS26200	COG1950	PFAM Membrane protein of
HYU01_RS26210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYU01_RS26215	COG0556	nucleotide-excision repair
HYU01_RS26235	COG0789	Transcriptional regulator
HYU01_RS26260	COG2855	membrane
HYU01_RS26265	COG0583	DNA-binding transcription factor activity
HYU01_RS26275	COG0655	NAD(P)H dehydrogenase (quinone) activity
HYU01_RS26280	COG0488	(ABC) transporter
HYU01_RS26290	COG1132	(ABC) transporter
HYU01_RS26295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYU01_RS26300	COG3409	Peptidoglycan-binding domain 1 protein
HYU01_RS26300	COG0793	Belongs to the peptidase S41A family
HYU01_RS26305	COG2177	Part of the ABC transporter FtsEX involved in
HYU01_RS26310	COG2884	Cell division ATP-binding protein ftsE
HYU01_RS26325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HYU01_RS26330	COG0653	protein targeting
HYU01_RS26335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HYU01_RS26340	COG1278	Cold shock
HYU01_RS26345	COG1040	competence protein
HYU01_RS26350	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HYU01_RS26355	COG0791	NLP P60 protein
HYU01_RS26355	COG1388	LysM domain
HYU01_RS26360	COG1733	regulation of RNA biosynthetic process
HYU01_RS26370	COG1307	EDD domain protein, DegV family
HYU01_RS26375	COG1739	Uncharacterized protein family UPF0029
HYU01_RS26380	COG1316	TRANSCRIPTIONal
HYU01_RS26385	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HYU01_RS26390	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HYU01_RS26395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYU01_RS26405	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYU01_RS26405	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HYU01_RS26420	COG3394	polysaccharide catabolic process
HYU01_RS26425	COG1486	melibiose metabolic process
HYU01_RS26430	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYU01_RS26435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYU01_RS26445	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYU01_RS26450	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYU01_RS26455	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYU01_RS26465	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYU01_RS26470	COG1301	dicarboxylic acid transport
HYU01_RS26480	COG0346	lactoylglutathione lyase activity
HYU01_RS26485	COG1511	domain protein
HYU01_RS26490	COG0583	DNA-binding transcription factor activity
HYU01_RS26495	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HYU01_RS26515	COG1271	oxidase subunit
HYU01_RS26520	COG1294	oxidase, subunit
HYU01_RS26525	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HYU01_RS26535	COG1620	l-lactate permease
HYU01_RS26545	COG2389	metal-binding protein
HYU01_RS26555	COG1368	sulfuric ester hydrolase activity
HYU01_RS26570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HYU01_RS26580	COG1215	transferase activity, transferring glycosyl groups
HYU01_RS26590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYU01_RS26595	COG1388	LysM domain
HYU01_RS26595	COG3584	3D domain protein
HYU01_RS26620	COG4715	Zinc finger, swim domain protein
HYU01_RS26625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYU01_RS26665	COG0577	efflux transmembrane transporter activity
HYU01_RS26670	COG1136	(ABC) transporter
HYU01_RS26705	COG5002	protein histidine kinase activity
HYU01_RS26710	COG0745	RESPONSE REGULATOR receiver
HYU01_RS26715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYU01_RS26735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HYU01_RS26740	COG1134	teichoic acid transport
HYU01_RS26745	COG1682	transport, permease protein
HYU01_RS26750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HYU01_RS26795	COG1609	Transcriptional regulator
HYU01_RS26810	COG0739	heme binding
HYU01_RS26825	COG3279	Response regulator of the LytR AlgR family
HYU01_RS26830	COG4555	ABC transporter
HYU01_RS26835	COG2385	sporulation resulting in formation of a cellular spore
HYU01_RS26850	COG4836	Membrane
HYU01_RS26855	COG1007	ATP synthesis coupled electron transport
HYU01_RS26860	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYU01_RS26865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYU01_RS26875	COG0839	Belongs to the complex I subunit 6 family
HYU01_RS26890	COG0649	NAD binding
HYU01_RS26895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYU01_RS26910	COG3300	MHYT domain
HYU01_RS26910	COG5001	Diguanylate cyclase
HYU01_RS26960	COG0356	it plays a direct role in the translocation of protons across the membrane
HYU01_RS26995	COG0698	ribose 5-phosphate isomerase
HYU01_RS27005	COG2190	(PTS) system
HYU01_RS27010	COG2259	Doxx family
HYU01_RS27015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYU01_RS27030	COG0009	L-threonylcarbamoyladenylate synthase
HYU01_RS27045	COG2890	protein-(glutamine-N5) methyltransferase activity
HYU01_RS27065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HYU01_RS27070	COG1494	fructose-1,6-bisphosphatase
HYU01_RS27090	COG4821	SIS domain
HYU01_RS27100	COG3343	RNA polymerase activity
HYU01_RS27110	COG1960	acyl-CoA dehydrogenase activity
HYU01_RS27115	COG1960	acyl-CoA dehydrogenase activity
HYU01_RS27120	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYU01_RS27125	COG0183	Belongs to the thiolase family
HYU01_RS27130	COG0247	lactate metabolic process
HYU01_RS27130	COG2181	nitrate reductase activity
HYU01_RS27135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYU01_RS27145	COG3300	MHYT domain
HYU01_RS27145	COG5001	Diguanylate cyclase
HYU01_RS27160	COG2197	response regulator
HYU01_RS27165	COG4585	Histidine kinase
HYU01_RS27170	COG0842	Transport permease protein
HYU01_RS27175	COG1131	(ABC) transporter
HYU01_RS27180	COG0024	Methionine aminopeptidase
HYU01_RS27195	COG2234	aminopeptidase activity
HYU01_RS27215	COG1595	DNA-templated transcription, initiation
HYU01_RS27220	COG0018	arginyl-trna synthetase
HYU01_RS27225	COG4506	Protein conserved in bacteria
HYU01_RS27230	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYU01_RS27250	COG0010	Belongs to the arginase family
HYU01_RS27260	COG2814	Major facilitator Superfamily
HYU01_RS27265	COG0789	Transcriptional regulator
HYU01_RS27270	COG0584	glycerophosphoryl diester phosphodiesterase
HYU01_RS27275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYU01_RS27285	COG1994	Peptidase M50
HYU01_RS27295	COG1078	dGTPase activity
HYU01_RS27300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYU01_RS27305	COG1120	ATPase activity
HYU01_RS27310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYU01_RS27315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYU01_RS27335	COG0095	Lipoate-protein ligase
HYU01_RS27340	COG0280	phosphate acetyltransferase
HYU01_RS27355	COG3773	Cell wall hydrolase
HYU01_RS27365	COG2363	Small membrane protein
HYU01_RS27375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYU01_RS27380	COG2233	PERMEase
HYU01_RS27385	COG0561	phosphatase activity
HYU01_RS27390	COG2814	Major facilitator Superfamily
HYU01_RS27400	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HYU01_RS27405	COG1131	(ABC) transporter
HYU01_RS27410	COG2755	lipolytic protein G-D-S-L family
HYU01_RS27415	COG1609	Transcriptional regulator
HYU01_RS27425	COG0460	homoserine dehydrogenase
HYU01_RS27435	COG2873	o-acetylhomoserine
HYU01_RS27445	COG1011	Hydrolase
HYU01_RS27450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYU01_RS27460	COG2197	response regulator
HYU01_RS27470	COG0351	phosphomethylpyrimidine kinase
HYU01_RS27475	COG3706	GGDEF domain
HYU01_RS27480	COG2879	small protein
HYU01_RS27485	COG1966	Carbon starvation protein
HYU01_RS27490	COG3279	Response regulator of the LytR AlgR family
HYU01_RS27495	COG0477	Major facilitator Superfamily
HYU01_RS27520	COG0840	transmembrane signaling receptor activity
HYU01_RS27530	COG1607	acyl-coa hydrolase
HYU01_RS27545	COG0488	(ABC) transporter
HYU01_RS27570	COG0463	Glycosyl transferase, family 2
HYU01_RS27575	COG1309	transcriptional regulator
HYU01_RS27580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYU01_RS27585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYU01_RS27585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYU01_RS27590	COG0628	permease
HYU01_RS27605	COG3279	Response regulator of the LytR AlgR family
HYU01_RS27610	COG3275	phosphorelay sensor kinase activity
HYU01_RS27615	COG2814	Major facilitator Superfamily
HYU01_RS27620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYU01_RS27625	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HYU01_RS27630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYU01_RS27650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYU01_RS27655	COG1272	protein, Hemolysin III
HYU01_RS27680	COG1164	Oligoendopeptidase f
HYU01_RS27700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYU01_RS27705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HYU01_RS27710	COG4853	Protein conserved in bacteria
HYU01_RS27715	COG4863	YycH protein
HYU01_RS27720	COG5002	protein histidine kinase activity
HYU01_RS27725	COG0745	RESPONSE REGULATOR receiver
HYU01_RS27755	COG0305	Participates in initiation and elongation during chromosome replication
HYU01_RS27765	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HYU01_RS27770	COG4241	membrane
HYU01_RS27780	COG0629	single-stranded DNA binding
HYU01_RS27790	COG0012	GTP binding
HYU01_RS27795	COG4481	Protein conserved in bacteria
HYU01_RS27800	COG0668	transmembrane transport
HYU01_RS27810	COG1475	DNA binding
HYU01_RS27815	COG1192	Involved in chromosome partitioning
HYU01_RS27840	COG1847	R3H domain protein
HYU01_RS27845	COG0706	membrane insertase activity
HYU01_RS27855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HYU01_RS28025	COG1774	PSP1 C-terminal conserved region
HYU01_RS28145	COG2208	phosphoserine phosphatase activity
HYU01_RS28285	COG0542	response to heat
HYU01_RS28375	COG0085	RNA polymerase activity
HYU01_RS28385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYU01_RS29195	COG2376	Dihydroxyacetone kinase