locus-tag	class	description
KM388_RS00010	COG0592	DNA-directed DNA polymerase activity
KM388_RS00015	COG2501	S4 domain
KM388_RS00025	COG0187	DNA topoisomerase II activity
KM388_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM388_RS00065	COG0516	GMP reductase activity
KM388_RS00065	COG0517	IMP dehydrogenase activity
KM388_RS00070	COG1686	Belongs to the peptidase S11 family
KM388_RS00100	COG1428	Deoxynucleoside kinase
KM388_RS00105	COG1428	Deoxynucleoside kinase
KM388_RS00110	COG1335	isochorismatase
KM388_RS00115	COG0590	tRNA wobble adenosine to inosine editing
KM388_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KM388_RS00180	COG1982	Orn Lys Arg decarboxylase major
KM388_RS00190	COG0470	DNA polymerase III
KM388_RS00195	COG1774	PSP1 C-terminal conserved region
KM388_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KM388_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KM388_RS00220	COG2002	toxin-antitoxin pair type II binding
KM388_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM388_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM388_RS00230	COG0084	hydrolase, TatD family'
KM388_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM388_RS00250	COG4466	Protein conserved in bacteria
KM388_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KM388_RS00270	COG0251	oxidation-reduction process
KM388_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KM388_RS00305	COG2002	toxin-antitoxin pair type II binding
KM388_RS00310	COG2244	polysaccharide biosynthetic process
KM388_RS00315	COG3956	TIGRFAM MazG family protein
KM388_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KM388_RS00340	COG1098	S1 RNA binding domain
KM388_RS00355	COG2208	phosphoserine phosphatase activity
KM388_RS00360	COG0037	tRNA processing
KM388_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM388_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM388_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM388_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KM388_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
KM388_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM388_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KM388_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KM388_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KM388_RS00420	COG1396	sequence-specific DNA binding
KM388_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM388_RS00455	COG3880	PFAM UvrB UvrC protein
KM388_RS00465	COG0542	response to heat
KM388_RS00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KM388_RS00480	COG4956	integral membrane protein (PIN domain superfamily)
KM388_RS00500	COG1045	serine acetyltransferase
KM388_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM388_RS00520	COG3688	RNA-binding protein containing a PIN domain
KM388_RS00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM388_RS00540	COG0250	Participates in transcription elongation, termination and antitermination
KM388_RS00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KM388_RS00565	COG2813	Specifically methylates the guanine in position
KM388_RS00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KM388_RS00580	COG1358	cellular component organization or biogenesis
KM388_RS00650	COG0255	Belongs to the universal ribosomal protein uL29 family
KM388_RS00710	COG0201	protein transport
KM388_RS00720	COG0024	Methionine aminopeptidase
KM388_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KM388_RS00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM388_RS00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM388_RS00795	COG0489	protein tyrosine kinase activity
KM388_RS00805	COG2194	sulfuric ester hydrolase activity
KM388_RS00810	COG0726	polysaccharide deacetylase
KM388_RS00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KM388_RS00895	COG4856	YbbR-like protein
KM388_RS00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM388_RS00915	COG0596	Alpha beta hydrolase
KM388_RS00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KM388_RS00940	COG0823	Involved in the tonB-independent uptake of proteins
KM388_RS00940	COG4946	Tricorn protease homolog
KM388_RS00940	COG1506	peptidase
KM388_RS00975	COG2011	ABC-type metal ion transport system permease component
KM388_RS00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM388_RS00985	COG1464	Belongs to the NlpA lipoprotein family
KM388_RS00990	COG0604	alcohol dehydrogenase
KM388_RS01005	COG2271	Major facilitator Superfamily
KM388_RS01015	COG2814	Major facilitator Superfamily
KM388_RS01030	COG0601	transmembrane transport
KM388_RS01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM388_RS01040	COG0444	Belongs to the ABC transporter superfamily
KM388_RS01045	COG4608	Belongs to the ABC transporter superfamily
KM388_RS01050	COG4166	transmembrane transport
KM388_RS01060	COG2207	Transcriptional regulator
KM388_RS01075	COG4166	transmembrane transport
KM388_RS01080	COG4166	transmembrane transport
KM388_RS01085	COG0656	L-ascorbic acid biosynthetic process
KM388_RS01105	COG4149	molybdate abc transporter
KM388_RS01110	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM388_RS01115	COG1910	domain protein
KM388_RS01125	COG0583	DNA-binding transcription factor activity
KM388_RS01130	COG0697	spore germination
KM388_RS01145	COG0204	Acyl-transferase
KM388_RS01155	COG1609	Transcriptional regulator
KM388_RS01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM388_RS01175	COG0084	hydrolase, TatD family'
KM388_RS01180	COG5298	Protein conserved in bacteria
KM388_RS01205	COG0488	(ABC) transporter
KM388_RS01220	COG0747	negative chemotaxis
KM388_RS01225	COG0601	transmembrane transport
KM388_RS01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM388_RS01235	COG0444	Belongs to the ABC transporter superfamily
KM388_RS01240	COG4608	Belongs to the ABC transporter superfamily
KM388_RS01265	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KM388_RS01270	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM388_RS01280	COG2814	Major facilitator Superfamily
KM388_RS01290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KM388_RS01300	COG4294	response to UV
KM388_RS01305	COG0705	Rhomboid family
KM388_RS01305	COG0457	Tetratricopeptide repeat
KM388_RS01315	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KM388_RS01320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM388_RS01325	COG0864	Transcriptional regulator
KM388_RS01330	COG2337	Toxic component of a toxin-antitoxin (TA) module
KM388_RS01335	COG2183	response to ionizing radiation
KM388_RS01430	COG0802	atpase or kinase
KM388_RS01435	COG1214	PFAM Peptidase M22, glycoprotease
KM388_RS01440	COG0456	acetyltransferase
KM388_RS01450	COG0488	(ABC) transporter
KM388_RS01465	COG1266	CAAX protease self-immunity
KM388_RS01485	COG2252	PERMEase
KM388_RS01495	COG5002	protein histidine kinase activity
KM388_RS01520	COG1968	undecaprenyl-diphosphatase activity
KM388_RS01535	COG2205	protein histidine kinase activity
KM388_RS01540	COG0745	RESPONSE REGULATOR receiver
KM388_RS01565	COG1968	undecaprenyl-diphosphatase activity
KM388_RS01580	COG2205	protein histidine kinase activity
KM388_RS01585	COG0745	RESPONSE REGULATOR receiver
KM388_RS01610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KM388_RS01615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KM388_RS01620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KM388_RS01630	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KM388_RS01645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KM388_RS01655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KM388_RS01665	COG0151	Belongs to the GarS family
KM388_RS01690	COG0210	DNA helicase
KM388_RS01700	COG4851	CamS sex pheromone cAM373 precursor
KM388_RS01720	COG1335	isochorismatase
KM388_RS01725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM388_RS01730	COG2011	ABC-type metal ion transport system permease component
KM388_RS01735	COG1464	Belongs to the NlpA lipoprotein family
KM388_RS01760	COG1846	Transcriptional regulator
KM388_RS01785	COG1597	lipid kinase activity
KM388_RS01790	COG0546	phosphoglycolate phosphatase activity
KM388_RS01795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM388_RS01805	COG1012	belongs to the aldehyde dehydrogenase family
KM388_RS01810	COG2076	Multidrug Resistance protein
KM388_RS01815	COG2309	aminopeptidase activity
KM388_RS01830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM388_RS01835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM388_RS01840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM388_RS01850	COG4807	Protein conserved in bacteria
KM388_RS01875	COG1757	Na H antiporter
KM388_RS01880	COG1473	amidohydrolase
KM388_RS01895	COG0450	alkyl hydroperoxide reductase
KM388_RS01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM388_RS01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM388_RS01925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM388_RS01940	COG0166	Belongs to the GPI family
KM388_RS01975	COG5002	protein histidine kinase activity
KM388_RS01995	COG3541	Predicted nucleotidyltransferase
KM388_RS02000	COG2814	Major facilitator Superfamily
KM388_RS02005	COG0723	plastoquinol--plastocyanin reductase activity
KM388_RS02005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM388_RS02015	COG0765	amino acid transport
KM388_RS02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM388_RS02030	COG0840	transmembrane signaling receptor activity
KM388_RS02035	COG0840	transmembrane signaling receptor activity
KM388_RS02040	COG0366	Alpha amylase catalytic
KM388_RS02045	COG1263	PTS System
KM388_RS02045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM388_RS02045	COG2190	(PTS) system
KM388_RS02075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KM388_RS02090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM388_RS02100	COG1116	anion transmembrane transporter activity
KM388_RS02105	COG0488	(ABC) transporter
KM388_RS02150	COG2270	Major facilitator Superfamily
KM388_RS02165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM388_RS02180	COG2310	stress, protein
KM388_RS02185	COG2310	stress, protein
KM388_RS02190	COG2310	stress, protein
KM388_RS02195	COG0861	Integral membrane protein TerC family
KM388_RS02205	COG3853	Toxic anion resistance protein (TelA)
KM388_RS02220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KM388_RS02230	COG1295	ribonuclease BN
KM388_RS02235	COG2217	Heavy metal translocating P-type atpase
KM388_RS02240	COG0697	spore germination
KM388_RS02260	COG0586	Pfam SNARE associated Golgi protein
KM388_RS02275	COG3871	stress protein (general stress protein 26)
KM388_RS02280	COG0387	Pfam Sodium calcium exchanger
KM388_RS02290	COG0535	radical SAM domain protein
KM388_RS02315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM388_RS02320	COG0582	viral genome integration into host DNA
KM388_RS02330	COG1396	sequence-specific DNA binding
KM388_RS02345	COG1396	sequence-specific DNA binding
KM388_RS02380	COG1484	DNA-dependent DNA replication
KM388_RS02610	COG0101	tRNA pseudouridine synthase activity
KM388_RS02620	COG3829	transcription factor binding
KM388_RS02630	COG0833	amino acid
KM388_RS02635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM388_RS02665	COG1263	PTS System
KM388_RS02665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM388_RS02670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM388_RS02685	COG0463	Glycosyl transferase, family 2
KM388_RS02695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KM388_RS02695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM388_RS02710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KM388_RS02730	COG1228	amidohydrolase
KM388_RS02735	COG1090	epimerase
KM388_RS02765	COG1988	membrane-bound metal-dependent
KM388_RS02770	COG1194	a g-specific adenine glycosylase
KM388_RS02795	COG1132	(ABC) transporter
KM388_RS02800	COG4129	membrane
KM388_RS02805	COG0067	glutamate synthase
KM388_RS02805	COG0069	glutamate synthase activity
KM388_RS02805	COG0070	glutamate synthase
KM388_RS02815	COG4555	ABC transporter
KM388_RS02835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KM388_RS02840	COG0735	belongs to the Fur family
KM388_RS02955	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KM388_RS02960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM388_RS02970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM388_RS02980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KM388_RS02990	COG2766	serine protein kinase
KM388_RS03010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM388_RS03020	COG1585	Membrane protein implicated in regulation of membrane protease activity
KM388_RS03025	COG2268	Band 7 protein
KM388_RS03035	COG3290	protein histidine kinase activity
KM388_RS03040	COG4565	transcriptional regulatory protein
KM388_RS03045	COG2851	Citrate transporter
KM388_RS03065	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM388_RS03070	COG3842	ATPase activity
KM388_RS03075	COG1175	transmembrane transport
KM388_RS03080	COG0395	ABC-type sugar transport system, permease component
KM388_RS03090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KM388_RS03095	COG0745	RESPONSE REGULATOR receiver
KM388_RS03100	COG5002	protein histidine kinase activity
KM388_RS03110	COG4990	cell redox homeostasis
KM388_RS03120	COG3290	protein histidine kinase activity
KM388_RS03125	COG4565	transcriptional regulatory protein
KM388_RS03130	COG3493	citrate carrier protein
KM388_RS03135	COG0281	malic enzyme
KM388_RS03150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM388_RS03160	COG5002	protein histidine kinase activity
KM388_RS03165	COG0745	RESPONSE REGULATOR receiver
KM388_RS03170	COG0454	-acetyltransferase
KM388_RS03170	COG0456	acetyltransferase
KM388_RS03175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM388_RS03180	COG3383	formate dehydrogenase (NAD+) activity
KM388_RS03200	COG0531	amino acid
KM388_RS03205	COG0640	Transcriptional regulator
KM388_RS03210	COG2217	Heavy metal translocating P-type atpase
KM388_RS03215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KM388_RS03230	COG3227	Zinc metalloprotease (Elastase)
KM388_RS03250	COG2720	vancomycin resistance protein
KM388_RS03255	COG1316	TRANSCRIPTIONal
KM388_RS03260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM388_RS03265	COG0346	lactoylglutathione lyase activity
KM388_RS03275	COG1027	Aspartate ammonia-lyase
KM388_RS03280	COG1620	l-lactate permease
KM388_RS03295	COG3104	oligopeptide transport
KM388_RS03300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM388_RS03305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM388_RS03310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM388_RS03320	COG2226	methyltransferase
KM388_RS03325	COG0156	8-amino-7-oxononanoate synthase activity
KM388_RS03330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM388_RS03340	COG4548	von Willebrand factor, type A
KM388_RS03345	COG0714	Associated with various cellular activities
KM388_RS03350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM388_RS03370	COG0531	amino acid
KM388_RS03375	COG2188	Transcriptional regulator
KM388_RS03380	COG1263	PTS System
KM388_RS03380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM388_RS03385	COG0366	Alpha amylase catalytic
KM388_RS03400	COG0697	spore germination
KM388_RS03410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM388_RS03415	COG1115	amino acid carrier protein
KM388_RS03420	COG1126	abc transporter atp-binding protein
KM388_RS03425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM388_RS03430	COG0765	amino acid transport
KM388_RS03435	COG0765	amino acid transport
KM388_RS03440	COG0833	amino acid
KM388_RS03465	COG2378	regulation of single-species biofilm formation
KM388_RS03470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KM388_RS03475	COG5002	protein histidine kinase activity
KM388_RS03490	COG0659	secondary active sulfate transmembrane transporter activity
KM388_RS03505	COG0747	negative chemotaxis
KM388_RS03515	COG0601	transmembrane transport
KM388_RS03520	COG4608	Belongs to the ABC transporter superfamily
KM388_RS03530	COG2271	Major facilitator Superfamily
KM388_RS03535	COG1846	Transcriptional regulator
KM388_RS03545	COG1609	Transcriptional regulator
KM388_RS03550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM388_RS03565	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM388_RS03570	COG1879	ABC-type sugar transport system periplasmic component
KM388_RS03595	COG1063	alcohol dehydrogenase
KM388_RS03610	COG3568	Endonuclease Exonuclease Phosphatase
KM388_RS03635	COG1968	undecaprenyl-diphosphatase activity
KM388_RS03640	COG0840	transmembrane signaling receptor activity
KM388_RS03645	COG1388	LysM domain
KM388_RS03645	COG3584	3D domain protein
KM388_RS03650	COG1476	TRANSCRIPTIONal
KM388_RS03665	COG3104	oligopeptide transport
KM388_RS03670	COG1114	Component of the transport system for branched-chain amino acids
KM388_RS03685	COG1113	amino acid transport
KM388_RS03690	COG2252	PERMEase
KM388_RS03715	COG0475	glutathione-regulated potassium exporter activity
KM388_RS03715	COG0569	domain protein
KM388_RS03730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM388_RS03735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KM388_RS03740	COG4990	cell redox homeostasis
KM388_RS03755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM388_RS03760	COG0697	spore germination
KM388_RS03765	COG0531	amino acid
KM388_RS03775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM388_RS03780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM388_RS03785	COG1918	ferrous iron import across plasma membrane
KM388_RS03785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM388_RS03790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM388_RS03795	COG0573	inorganic phosphate transmembrane transporter activity
KM388_RS03800	COG0581	inorganic phosphate transmembrane transporter activity
KM388_RS03810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM388_RS03930	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KM388_RS03950	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM388_RS03955	COG1116	anion transmembrane transporter activity
KM388_RS03960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM388_RS03965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM388_RS03970	COG0352	thiamine-phosphate diphosphorylase activity
KM388_RS03975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM388_RS03980	COG2104	thiamine diphosphate biosynthetic process
KM388_RS03990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM388_RS03995	COG0351	phosphomethylpyrimidine kinase
KM388_RS04035	COG2205	protein histidine kinase activity
KM388_RS04040	COG2814	Major facilitator Superfamily
KM388_RS04045	COG1846	Transcriptional regulator
KM388_RS04060	COG2252	PERMEase
KM388_RS04065	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS04070	COG1376	ErfK ybiS ycfS ynhG family protein
KM388_RS04080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM388_RS04085	COG1621	beta-fructofuranosidase activity
KM388_RS04090	COG1263	PTS System
KM388_RS04090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM388_RS04095	COG1609	Transcriptional regulator
KM388_RS04105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM388_RS04145	COG0778	Nitroreductase
KM388_RS04150	COG2719	SpoVR family
KM388_RS04175	COG0446	pyridine nucleotide-disulphide oxidoreductase
KM388_RS04180	COG1937	Protein conserved in bacteria
KM388_RS04185	COG0425	Belongs to the sulfur carrier protein TusA family
KM388_RS04185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM388_RS04190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM388_RS04190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM388_RS04195	COG0425	Belongs to the sulfur carrier protein TusA family
KM388_RS04210	COG2210	Belongs to the sulfur carrier protein TusA family
KM388_RS04215	COG0730	response to heat
KM388_RS04225	COG1316	TRANSCRIPTIONal
KM388_RS04230	COG0604	alcohol dehydrogenase
KM388_RS04235	COG1283	sodium-dependent phosphate transmembrane transporter activity
KM388_RS04250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM388_RS04250	COG3711	transcriptional antiterminator
KM388_RS04255	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM388_RS04260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM388_RS04280	COG3584	3D domain protein
KM388_RS04280	COG1388	LysM domain
KM388_RS04285	COG0577	efflux transmembrane transporter activity
KM388_RS04290	COG1136	(ABC) transporter
KM388_RS04300	COG5522	Integral membrane protein (intg_mem_TP0381)
KM388_RS04315	COG1114	Component of the transport system for branched-chain amino acids
KM388_RS04320	COG3546	catalase activity
KM388_RS04355	COG0586	Pfam SNARE associated Golgi protein
KM388_RS04395	COG0531	amino acid
KM388_RS04400	COG0475	glutathione-regulated potassium exporter activity
KM388_RS04410	COG1737	Transcriptional regulator
KM388_RS04420	COG1263	PTS System
KM388_RS04420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM388_RS04430	COG2259	Doxx family
KM388_RS04445	COG0697	spore germination
KM388_RS04450	COG1522	sequence-specific DNA binding
KM388_RS04465	COG2076	Multidrug Resistance protein
KM388_RS04470	COG1309	transcriptional regulator
KM388_RS04475	COG2814	Major facilitator Superfamily
KM388_RS04480	COG1733	regulation of RNA biosynthetic process
KM388_RS04490	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM388_RS04495	COG4533	DNA binding
KM388_RS04500	COG2814	Major facilitator Superfamily
KM388_RS04510	COG0693	protein deglycase activity
KM388_RS04515	COG0693	protein deglycase activity
KM388_RS04515	COG0753	catalase activity
KM388_RS04525	COG0531	amino acid
KM388_RS04530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KM388_RS04540	COG1012	belongs to the aldehyde dehydrogenase family
KM388_RS04545	COG1132	(ABC) transporter
KM388_RS04555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM388_RS04560	COG0765	amino acid transport
KM388_RS04565	COG1126	abc transporter atp-binding protein
KM388_RS04580	COG0189	ligase activity
KM388_RS04610	COG0028	Belongs to the TPP enzyme family
KM388_RS04615	COG3527	Alpha-acetolactate decarboxylase
KM388_RS04630	COG0561	phosphatase activity
KM388_RS04645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM388_RS04660	COG0659	secondary active sulfate transmembrane transporter activity
KM388_RS04680	COG0653	protein targeting
KM388_RS04685	COG2244	polysaccharide biosynthetic process
KM388_RS04695	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM388_RS04700	COG4196	transglutaminase domain protein
KM388_RS04715	COG1696	Membrane protein involved in D-alanine export
KM388_RS04730	COG1024	Enoyl-CoA hydratase
KM388_RS04745	COG1363	Peptidase, m42
KM388_RS04765	COG3938	Belongs to the proline racemase family
KM388_RS04805	COG0601	transmembrane transport
KM388_RS04810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM388_RS04820	COG4608	Belongs to the ABC transporter superfamily
KM388_RS04855	COG0477	Major facilitator Superfamily
KM388_RS04860	COG3290	protein histidine kinase activity
KM388_RS04865	COG4565	transcriptional regulatory protein
KM388_RS04870	COG3181	Tripartite tricarboxylate transporter family receptor
KM388_RS04900	COG4978	Transcriptional regulator
KM388_RS04900	COG0789	Transcriptional regulator
KM388_RS04915	COG0305	Participates in initiation and elongation during chromosome replication
KM388_RS04955	COG0477	Major facilitator Superfamily
KM388_RS05005	COG1309	transcriptional regulator
KM388_RS05025	COG1183	phosphatidylcholine synthase activity
KM388_RS05045	COG2376	Dihydroxyacetone kinase
KM388_RS05055	COG2376	Dihydroxyacetone kinase
KM388_RS05060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM388_RS05065	COG1959	2 iron, 2 sulfur cluster binding
KM388_RS05095	COG3437	response regulator, receiver
KM388_RS05095	COG2770	Histidine kinase
KM388_RS05145	COG3237	CsbD-like
KM388_RS05170	COG1191	sigma factor activity
KM388_RS05180	COG2208	phosphoserine phosphatase activity
KM388_RS05185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM388_RS05190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM388_RS05190	COG0784	Response regulator, receiver
KM388_RS05190	COG2198	Histidine kinase
KM388_RS05190	COG2205	protein histidine kinase activity
KM388_RS05245	COG0420	3'-5' exonuclease activity
KM388_RS05270	COG1309	transcriptional regulator
KM388_RS05275	COG2814	Major facilitator Superfamily
KM388_RS05280	COG0346	lactoylglutathione lyase activity
KM388_RS05285	COG0346	lactoylglutathione lyase activity
KM388_RS05290	COG0457	Tetratricopeptide repeat
KM388_RS05295	COG2267	carboxylic ester hydrolase activity
KM388_RS05315	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM388_RS05320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KM388_RS05330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KM388_RS05370	COG0477	Major facilitator Superfamily
KM388_RS05375	COG0477	Major facilitator Superfamily
KM388_RS05385	COG3973	AAA domain
KM388_RS05390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM388_RS05410	COG4980	gas vesicle protein
KM388_RS05415	COG0537	adenosine 5'-monophosphoramidase activity
KM388_RS05420	COG1131	(ABC) transporter
KM388_RS05425	COG4473	ABC transporter
KM388_RS05440	COG1309	transcriptional regulator
KM388_RS05450	COG3402	PFAM membrane-flanked domain
KM388_RS05495	COG3402	PFAM membrane-flanked domain
KM388_RS05500	COG3428	Bacterial PH domain
KM388_RS05505	COG2329	Antibiotic biosynthesis monooxygenase
KM388_RS05510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM388_RS05515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KM388_RS05520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM388_RS05525	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM388_RS05560	COG1309	transcriptional regulator
KM388_RS05565	COG1511	domain protein
KM388_RS05590	COG1609	Transcriptional regulator
KM388_RS05600	COG1234	tRNA 3'-trailer cleavage
KM388_RS05605	COG0095	Lipoate-protein ligase
KM388_RS05615	COG0318	PFAM AMP-dependent synthetase and ligase
KM388_RS05645	COG3209	COG3209 Rhs family protein
KM388_RS05685	COG1078	dGTPase activity
KM388_RS05695	COG1595	DNA-templated transcription, initiation
KM388_RS05700	COG2207	Transcriptional regulator
KM388_RS05700	COG3708	Transcriptional regulator
KM388_RS05715	COG2205	protein histidine kinase activity
KM388_RS05720	COG0745	RESPONSE REGULATOR receiver
KM388_RS05745	COG0501	Belongs to the peptidase M48B family
KM388_RS05750	COG0840	transmembrane signaling receptor activity
KM388_RS05755	COG0697	spore germination
KM388_RS05775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KM388_RS05780	COG2224	Isocitrate lyase
KM388_RS05805	COG4903	ComK protein
KM388_RS05810	COG0398	Pfam SNARE associated Golgi protein
KM388_RS05820	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KM388_RS05825	COG1074	ATP-dependent DNA helicase activity
KM388_RS05870	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM388_RS05895	COG0367	asparagine synthase
KM388_RS05900	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM388_RS05905	COG0753	catalase activity
KM388_RS05910	COG0004	ammonium transporteR
KM388_RS05930	COG2996	Protein conserved in bacteria
KM388_RS05940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM388_RS05950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM388_RS05965	COG0561	phosphatase activity
KM388_RS05975	COG0542	response to heat
KM388_RS06000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM388_RS06005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KM388_RS06010	COG5504	Zn-dependent protease
KM388_RS06020	COG0180	Tryptophanyl-tRNA synthetase
KM388_RS06030	COG4166	transmembrane transport
KM388_RS06035	COG0601	transmembrane transport
KM388_RS06040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM388_RS06045	COG0444	Belongs to the ABC transporter superfamily
KM388_RS06050	COG4608	Belongs to the ABC transporter superfamily
KM388_RS06055	COG0534	Mate efflux family protein
KM388_RS06060	COG4166	transmembrane transport
KM388_RS06075	COG0861	Integral membrane protein TerC family
KM388_RS06080	COG4862	establishment of competence for transformation
KM388_RS06085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM388_RS06095	COG1164	Oligoendopeptidase f
KM388_RS06105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM388_RS06110	COG2346	COG2346, Truncated hemoglobins
KM388_RS06115	COG4116	CYTH
KM388_RS06125	COG2357	RelA SpoT domain protein
KM388_RS06135	COG0564	pseudouridine synthase activity
KM388_RS06155	COG1216	Glycosyl transferase, family 2
KM388_RS06155	COG0463	Glycosyl transferase, family 2
KM388_RS06175	COG0463	Glycosyl transferase, family 2
KM388_RS06175	COG0457	Tetratricopeptide repeat
KM388_RS06195	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KM388_RS06210	COG1091	dTDP-4-dehydrorhamnose reductase activity
KM388_RS06255	COG2153	protein acetylation
KM388_RS06265	COG2382	esterase
KM388_RS06280	COG5492	domain, Protein
KM388_RS06285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM388_RS06295	COG0512	Glutamine amidotransferase of anthranilate synthase
KM388_RS06295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KM388_RS06330	COG1620	l-lactate permease
KM388_RS06335	COG5634	Uncharacterized conserved protein (DUF2278)
KM388_RS06390	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM388_RS06400	COG1476	TRANSCRIPTIONal
KM388_RS06460	COG2226	methyltransferase
KM388_RS06470	COG1686	Belongs to the peptidase S11 family
KM388_RS06475	COG0681	Belongs to the peptidase S26 family
KM388_RS06510	COG1012	belongs to the aldehyde dehydrogenase family
KM388_RS06515	COG3842	ATPase activity
KM388_RS06520	COG1176	ABC-type spermidine putrescine transport system, permease component I
KM388_RS06525	COG1177	transmembrane transport
KM388_RS06530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM388_RS06540	COG2409	Drug exporters of the RND superfamily
KM388_RS06550	COG0564	pseudouridine synthase activity
KM388_RS06560	COG2340	Cysteine-rich secretory protein family
KM388_RS06565	COG0247	lactate metabolic process
KM388_RS06570	COG0277	FAD linked oxidase domain protein
KM388_RS06575	COG3835	regulator
KM388_RS06585	COG0745	RESPONSE REGULATOR receiver
KM388_RS06590	COG5002	protein histidine kinase activity
KM388_RS06595	COG2186	Transcriptional regulator
KM388_RS06615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KM388_RS06625	COG2116	formate transmembrane transporter activity
KM388_RS06630	COG0861	Integral membrane protein TerC family
KM388_RS06645	COG2030	dehydratase
KM388_RS06665	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS06670	COG3243	poly(R)-hydroxyalkanoic acid synthase
KM388_RS06675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM388_RS06680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM388_RS06695	COG1840	ABC-type Fe3 transport system, periplasmic component
KM388_RS06725	COG1349	DNA-binding transcription factor activity
KM388_RS06745	COG2861	carbohydrate metabolic process
KM388_RS06755	COG3852	Histidine kinase
KM388_RS06760	COG1846	Transcriptional regulator
KM388_RS06770	COG2318	DinB family
KM388_RS06780	COG5002	protein histidine kinase activity
KM388_RS06790	COG0720	synthase
KM388_RS06805	COG4873	Protein conserved in bacteria
KM388_RS06835	COG1780	Probably involved in ribonucleotide reductase function
KM388_RS06855	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM388_RS06860	COG1725	Transcriptional regulator
KM388_RS06865	COG1131	(ABC) transporter
KM388_RS06875	COG1131	(ABC) transporter
KM388_RS06880	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM388_RS06895	COG1522	sequence-specific DNA binding
KM388_RS06905	COG1335	isochorismatase
KM388_RS06915	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM388_RS06920	COG2070	2-Nitropropane dioxygenase
KM388_RS06925	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM388_RS06935	COG1696	Membrane protein involved in D-alanine export
KM388_RS06960	COG0716	FMN binding
KM388_RS06975	COG3173	Aminoglycoside phosphotransferase
KM388_RS06995	COG0534	Mate efflux family protein
KM388_RS07000	COG1968	undecaprenyl-diphosphatase activity
KM388_RS07015	COG1846	Transcriptional regulator
KM388_RS07025	COG1301	dicarboxylic acid transport
KM388_RS07030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM388_RS07035	COG4709	membrane
KM388_RS07040	COG3874	Sporulation protein YtfJ
KM388_RS07060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM388_RS07065	COG0028	Belongs to the TPP enzyme family
KM388_RS07070	COG0440	acetolactate synthase activity
KM388_RS07075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM388_RS07085	COG0473	3-isopropylmalate dehydrogenase activity
KM388_RS07110	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KM388_RS07145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM388_RS07160	COG1183	phosphatidylcholine synthase activity
KM388_RS07165	COG1368	sulfuric ester hydrolase activity
KM388_RS07175	COG0019	diaminopimelate decarboxylase activity
KM388_RS07195	COG0529	Catalyzes the synthesis of activated sulfate
KM388_RS07200	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM388_RS07220	COG1648	precorrin-2 dehydrogenase activity
KM388_RS07225	COG0733	neurotransmitter:sodium symporter activity
KM388_RS07245	COG1757	Na H antiporter
KM388_RS07260	COG4758	membrane
KM388_RS07265	COG4585	Histidine kinase
KM388_RS07270	COG2197	response regulator
KM388_RS07280	COG1114	Component of the transport system for branched-chain amino acids
KM388_RS07290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KM388_RS07315	COG1017	nitric oxide dioxygenase activity
KM388_RS07315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KM388_RS07330	COG0730	response to heat
KM388_RS07335	COG0306	phosphate transporter
KM388_RS07340	COG1392	Phosphate transport regulator
KM388_RS07365	COG1801	Protein of unknown function DUF72
KM388_RS07375	COG0582	viral genome integration into host DNA
KM388_RS07380	COG5002	protein histidine kinase activity
KM388_RS07400	COG0392	lysyltransferase activity
KM388_RS07400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KM388_RS07415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM388_RS07420	COG1686	Belongs to the peptidase S11 family
KM388_RS07425	COG2715	membrane protein required for spore maturation
KM388_RS07430	COG0700	Nucleoside recognition
KM388_RS07435	COG1187	pseudouridine synthase activity
KM388_RS07445	COG1333	cytochrome c biogenesis protein
KM388_RS07450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM388_RS07455	COG0745	RESPONSE REGULATOR receiver
KM388_RS07460	COG5002	protein histidine kinase activity
KM388_RS07465	COG2096	Adenosyltransferase
KM388_RS07480	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KM388_RS07485	COG1141	Ferredoxin
KM388_RS07490	COG4955	Helix-turn-helix domain
KM388_RS07495	COG0514	ATP-dependent DNA helicase (RecQ)
KM388_RS07500	COG1266	CAAX protease self-immunity
KM388_RS07520	COG4862	establishment of competence for transformation
KM388_RS07525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KM388_RS07545	COG0492	ferredoxin-NADP+ reductase activity
KM388_RS07550	COG0252	asparaginase activity
KM388_RS07620	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM388_RS07635	COG0142	geranyltranstransferase activity
KM388_RS07645	COG0142	geranyltranstransferase activity
KM388_RS07665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM388_RS07670	COG0457	Tetratricopeptide repeat
KM388_RS07690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KM388_RS07700	COG4347	Protein of unknown function (DUF1405)
KM388_RS07715	COG2738	Putative neutral zinc metallopeptidase
KM388_RS07725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM388_RS07730	COG1694	Mazg nucleotide pyrophosphohydrolase
KM388_RS07745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM388_RS07750	COG0438	transferase activity, transferring glycosyl groups
KM388_RS07805	COG3935	DnaD domain protein
KM388_RS07810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KM388_RS07820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM388_RS07820	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM388_RS07880	COG0116	Belongs to the methyltransferase superfamily
KM388_RS07890	COG1199	ATP-dependent helicase activity
KM388_RS07895	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KM388_RS07905	COG3173	Aminoglycoside phosphotransferase
KM388_RS07910	COG0024	Methionine aminopeptidase
KM388_RS07920	COG2233	PERMEase
KM388_RS07925	COG2311	Membrane
KM388_RS07930	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM388_RS07940	COG0456	acetyltransferase
KM388_RS07990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM388_RS08015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KM388_RS08030	COG1215	transferase activity, transferring glycosyl groups
KM388_RS08050	COG0454	-acetyltransferase
KM388_RS08070	COG0328	RNA-DNA hybrid ribonuclease activity
KM388_RS08110	COG1280	lysine exporter protein (LysE YggA)
KM388_RS08125	COG3162	membrane
KM388_RS08130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM388_RS08135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM388_RS08145	COG0475	glutathione-regulated potassium exporter activity
KM388_RS08150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM388_RS08155	COG4978	Transcriptional regulator
KM388_RS08155	COG0789	Transcriptional regulator
KM388_RS08165	COG2323	membrane
KM388_RS08170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KM388_RS08225	COG1923	regulation of RNA biosynthetic process
KM388_RS08235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM388_RS08240	COG1360	Flagellar Motor Protein
KM388_RS08245	COG2201	protein-glutamate methylesterase activity
KM388_RS08255	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM388_RS08255	COG1776	CheC inhibitor of MCP methylation
KM388_RS08270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM388_RS08290	COG1256	bacterial-type flagellum assembly
KM388_RS08315	COG1815	bacterial-type flagellum-dependent cell motility
KM388_RS08320	COG1558	bacterial-type flagellum-dependent cell motility
KM388_RS08335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM388_RS08345	COG1157	protein secretion by the type III secretion system
KM388_RS08380	COG0784	Response regulator, receiver
KM388_RS08380	COG0835	chemotaxis
KM388_RS08390	COG0463	Glycosyl transferase, family 2
KM388_RS08415	COG0463	Glycosyl transferase, family 2
KM388_RS08415	COG0457	Tetratricopeptide repeat
KM388_RS08430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM388_RS08435	COG0741	lytic transglycosylase activity
KM388_RS08450	COG1776	CheC inhibitor of MCP methylation
KM388_RS08450	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM388_RS08460	COG1338	Plays a role in the flagellum-specific transport system
KM388_RS08465	COG1987	bacterial-type flagellum assembly
KM388_RS08475	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM388_RS08480	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM388_RS08485	COG1419	protein localization to endoplasmic reticulum
KM388_RS08490	COG4786	Flagellar basal body rod
KM388_RS08495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM388_RS08520	COG1309	transcriptional regulator
KM388_RS08540	COG2329	Antibiotic biosynthesis monooxygenase
KM388_RS08570	COG3842	ATPase activity
KM388_RS08575	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM388_RS08585	COG1234	tRNA 3'-trailer cleavage
KM388_RS08610	COG1686	Belongs to the peptidase S11 family
KM388_RS08650	COG0367	asparagine synthase
KM388_RS08680	COG1802	Transcriptional regulator
KM388_RS08685	COG0697	spore germination
KM388_RS08690	COG0523	cobalamin synthesis protein
KM388_RS08695	COG0701	Predicted permease
KM388_RS08705	COG1216	Glycosyl transferase, family 2
KM388_RS08705	COG0438	transferase activity, transferring glycosyl groups
KM388_RS08710	COG1757	Na H antiporter
KM388_RS08715	COG0114	fumarate hydratase activity
KM388_RS08740	COG3340	Belongs to the peptidase S51 family
KM388_RS08760	COG0785	Cytochrome C biogenesis protein
KM388_RS08790	COG2733	membrane
KM388_RS08825	COG1131	(ABC) transporter
KM388_RS08840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM388_RS08845	COG0528	UMP kinase activity
KM388_RS08855	COG1027	Aspartate ammonia-lyase
KM388_RS08860	COG0281	malic enzyme
KM388_RS08865	COG4191	Histidine kinase
KM388_RS08870	COG0784	Response regulator, receiver
KM388_RS08875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM388_RS08935	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM388_RS08945	COG2814	Major facilitator Superfamily
KM388_RS08960	COG1966	Carbon starvation protein
KM388_RS08970	COG0477	Major facilitator Superfamily
KM388_RS08975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM388_RS08985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM388_RS09015	COG2244	polysaccharide biosynthetic process
KM388_RS09020	COG0733	neurotransmitter:sodium symporter activity
KM388_RS09030	COG5566	PFAM Mor transcription activator
KM388_RS09035	COG2323	membrane
KM388_RS09055	COG2084	Dehydrogenase
KM388_RS09070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM388_RS09080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM388_RS09085	COG0028	Belongs to the TPP enzyme family
KM388_RS09090	COG0440	acetolactate synthase activity
KM388_RS09095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM388_RS09105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KM388_RS09135	COG3384	dioxygenase
KM388_RS09145	COG3279	Response regulator of the LytR AlgR family
KM388_RS09150	COG0427	acetyl-CoA hydrolase
KM388_RS09170	COG1073	alpha beta
KM388_RS09175	COG4166	transmembrane transport
KM388_RS09200	COG0535	radical SAM domain protein
KM388_RS09205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM388_RS09225	COG1914	H( )-stimulated, divalent metal cation uptake system
KM388_RS09240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM388_RS09270	COG2390	Transcriptional regulator
KM388_RS09280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM388_RS09285	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KM388_RS09300	COG4224	UPF0291 protein
KM388_RS09320	COG0006	proline dipeptidase activity
KM388_RS09325	COG2132	Multicopper oxidase
KM388_RS09340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM388_RS09355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM388_RS09370	COG2372	response to copper ion
KM388_RS09370	COG1276	copper resistance
KM388_RS09375	COG4549	nuclear export factor GLE1
KM388_RS09385	COG0697	spore germination
KM388_RS09390	COG0583	DNA-binding transcription factor activity
KM388_RS09395	COG1959	2 iron, 2 sulfur cluster binding
KM388_RS09400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM388_RS09405	COG0778	Nitroreductase
KM388_RS09415	COG0628	permease
KM388_RS09425	COG1231	oxidoreductase activity
KM388_RS09430	COG0523	cobalamin synthesis protein
KM388_RS09445	COG0318	PFAM AMP-dependent synthetase and ligase
KM388_RS09450	COG2030	dehydratase
KM388_RS09455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM388_RS09465	COG0411	ABC transporter
KM388_RS09485	COG0583	DNA-binding transcription factor activity
KM388_RS09495	COG1942	4-Oxalocrotonate Tautomerase
KM388_RS09505	COG1846	Transcriptional regulator
KM388_RS09515	COG1271	oxidase subunit
KM388_RS09520	COG1294	oxidase, subunit
KM388_RS09525	COG4988	ABC transporter
KM388_RS09530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KM388_RS09550	COG1686	Belongs to the peptidase S11 family
KM388_RS09565	COG0791	NLP P60 protein
KM388_RS09565	COG1388	LysM domain
KM388_RS09580	COG0745	RESPONSE REGULATOR receiver
KM388_RS09595	COG0300	oxidoreductase activity
KM388_RS09630	COG0460	homoserine dehydrogenase
KM388_RS09655	COG1316	TRANSCRIPTIONal
KM388_RS09665	COG0745	RESPONSE REGULATOR receiver
KM388_RS09670	COG5002	protein histidine kinase activity
KM388_RS09685	COG1285	pathogenesis
KM388_RS09690	COG1247	-acetyltransferase
KM388_RS09710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM388_RS09720	COG1082	Xylose isomerase domain protein TIM barrel
KM388_RS09730	COG2814	Major facilitator Superfamily
KM388_RS09735	COG1279	arginine transmembrane transporter activity
KM388_RS09745	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM388_RS09780	COG0577	efflux transmembrane transporter activity
KM388_RS09785	COG2002	toxin-antitoxin pair type II binding
KM388_RS09790	COG1404	Belongs to the peptidase S8 family
KM388_RS09795	COG0640	Transcriptional regulator
KM388_RS09800	COG0667	Aldo Keto reductase
KM388_RS09805	COG2814	Major facilitator Superfamily
KM388_RS09830	COG0840	transmembrane signaling receptor activity
KM388_RS09845	COG3949	Membrane
KM388_RS09850	COG0783	Belongs to the Dps family
KM388_RS09865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM388_RS09875	COG1231	oxidoreductase activity
KM388_RS09885	COG4989	oxidoreductase activity
KM388_RS09890	COG0523	cobalamin synthesis protein
KM388_RS09895	COG0456	acetyltransferase
KM388_RS09950	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM388_RS09950	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM388_RS09960	COG0702	epimerase
KM388_RS09970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM388_RS09980	COG4166	transmembrane transport
KM388_RS09995	COG0406	alpha-ribazole phosphatase activity
KM388_RS10005	COG5337	Spore coat protein CotH
KM388_RS10010	COG1051	belongs to the nudix hydrolase family
KM388_RS10015	COG0586	Pfam SNARE associated Golgi protein
KM388_RS10020	COG2244	polysaccharide biosynthetic process
KM388_RS10030	COG0701	Predicted permease
KM388_RS10035	COG3689	TIGRFAM TIGR03943 family protein
KM388_RS10040	COG1607	acyl-coa hydrolase
KM388_RS10050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM388_RS10065	COG0702	epimerase
KM388_RS10070	COG2839	Protein conserved in bacteria
KM388_RS10075	COG1253	flavin adenine dinucleotide binding
KM388_RS10090	COG1114	Component of the transport system for branched-chain amino acids
KM388_RS10095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM388_RS10115	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM388_RS10125	COG1876	peptidase activity
KM388_RS10135	COG0154	amidase activity
KM388_RS10140	COG2211	Major facilitator Superfamily
KM388_RS10160	COG0561	phosphatase activity
KM388_RS10170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM388_RS10175	COG4106	trans-aconitate 2-methyltransferase activity
KM388_RS10190	COG1819	glycosyl
KM388_RS10195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM388_RS10200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM388_RS10235	COG0456	acetyltransferase
KM388_RS10290	COG3874	Sporulation protein YtfJ
KM388_RS10340	COG0346	lactoylglutathione lyase activity
KM388_RS10350	COG0604	alcohol dehydrogenase
KM388_RS10355	COG1595	DNA-templated transcription, initiation
KM388_RS10380	COG0386	Belongs to the glutathione peroxidase family
KM388_RS10385	COG1305	Transglutaminase-like
KM388_RS10390	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KM388_RS10395	COG0714	Associated with various cellular activities
KM388_RS10410	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KM388_RS10415	COG1140	nitrate reductase beta subunit
KM388_RS10420	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KM388_RS10425	COG2181	nitrate reductase activity
KM388_RS10445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM388_RS10450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM388_RS10455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM388_RS10460	COG0303	'Molybdopterin
KM388_RS10465	COG0314	molybdopterin synthase activity
KM388_RS10475	COG2223	nitrite transmembrane transporter activity
KM388_RS10490	COG1648	precorrin-2 dehydrogenase activity
KM388_RS10500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM388_RS10500	COG1587	Uroporphyrinogen-III synthase
KM388_RS10505	COG2146	nitrite reductase [NAD(P)H] activity
KM388_RS10510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM388_RS10515	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KM388_RS10550	COG2359	stage V sporulation protein S
KM388_RS10575	COG1418	mRNA catabolic process
KM388_RS10580	COG0488	(ABC) transporter
KM388_RS10595	COG0629	single-stranded DNA binding
KM388_RS10610	COG1413	lyase activity
KM388_RS10625	COG2521	methyltransferase
KM388_RS10625	COG2136	Putative SAM-dependent methyltransferase
KM388_RS10630	COG0018	arginyl-trna synthetase
KM388_RS10655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KM388_RS10675	COG0017	Asparaginyl-tRNA synthetase
KM388_RS10695	COG1674	ftsk spoiiie
KM388_RS10765	COG1929	Belongs to the glycerate kinase type-1 family
KM388_RS10770	COG0471	metal ion transport
KM388_RS10775	COG0745	RESPONSE REGULATOR receiver
KM388_RS10780	COG3850	Histidine kinase
KM388_RS10780	COG5002	protein histidine kinase activity
KM388_RS10795	COG0733	neurotransmitter:sodium symporter activity
KM388_RS10820	COG2610	gluconate transmembrane transporter activity
KM388_RS10825	COG1454	alcohol dehydrogenase
KM388_RS10830	COG1794	racemase activity, acting on amino acids and derivatives
KM388_RS10840	COG0456	acetyltransferase
KM388_RS10855	COG1131	(ABC) transporter
KM388_RS10870	COG0546	phosphoglycolate phosphatase activity
KM388_RS10890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM388_RS10905	COG0768	penicillin binding
KM388_RS10910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM388_RS10915	COG0204	Acyl-transferase
KM388_RS10920	COG1272	protein, Hemolysin III
KM388_RS10930	COG0805	protein transport
KM388_RS10940	COG1307	EDD domain protein, DegV family
KM388_RS10945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KM388_RS10950	COG1999	signal sequence binding
KM388_RS10955	COG0071	Belongs to the small heat shock protein (HSP20) family
KM388_RS10960	COG0367	asparagine synthase
KM388_RS10980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM388_RS10985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM388_RS11020	COG0668	transmembrane transport
KM388_RS11025	COG4585	Histidine kinase
KM388_RS11025	COG2203	Gaf domain
KM388_RS11030	COG2197	response regulator
KM388_RS11040	COG1064	alcohol dehydrogenase
KM388_RS11095	COG0517	IMP dehydrogenase activity
KM388_RS11095	COG1125	glycine betaine transport
KM388_RS11100	COG1174	glycine betaine transport
KM388_RS11135	COG1253	flavin adenine dinucleotide binding
KM388_RS11140	COG1012	belongs to the aldehyde dehydrogenase family
KM388_RS11145	COG5506	Protein of unknown function (DUF1694)
KM388_RS11160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM388_RS11165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KM388_RS11170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KM388_RS11175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM388_RS11180	COG0456	acetyltransferase
KM388_RS11185	COG3829	transcription factor binding
KM388_RS11190	COG1509	lysine 2,3-aminomutase activity
KM388_RS11230	COG4326	sporulation control protein
KM388_RS11235	COG0671	phosphoesterase, PA-phosphatase related
KM388_RS11240	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM388_RS11245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM388_RS11275	COG1787	Restriction endonuclease
KM388_RS11275	COG1715	Restriction endonuclease
KM388_RS11365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM388_RS11405	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM388_RS11405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM388_RS11415	COG2814	Major facilitator Superfamily
KM388_RS11420	COG4841	protein insertion into membrane
KM388_RS11425	COG0372	Belongs to the citrate synthase family
KM388_RS11430	COG2079	MmgE PrpD family protein
KM388_RS11435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KM388_RS11440	COG1960	acyl-CoA dehydrogenase activity
KM388_RS11445	COG2084	Dehydrogenase
KM388_RS11455	COG1280	lysine exporter protein (LysE YggA)
KM388_RS11460	COG1024	Enoyl-CoA hydratase
KM388_RS11475	COG0420	3'-5' exonuclease activity
KM388_RS11480	COG0419	ATPase involved in DNA repair
KM388_RS11500	COG2223	nitrite transmembrane transporter activity
KM388_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS11510	COG1169	isochorismate synthase
KM388_RS11515	COG1021	2,3-dihydroxybenzoate-AMP ligase
KM388_RS11520	COG1535	isochorismatase
KM388_RS11520	COG3433	isochorismatase activity
KM388_RS11530	COG3251	PFAM MbtH domain protein
KM388_RS11535	COG2814	Major facilitator Superfamily
KM388_RS11550	COG0776	regulation of translation
KM388_RS11560	COG2318	DinB family
KM388_RS11585	COG2329	Antibiotic biosynthesis monooxygenase
KM388_RS11590	COG1187	pseudouridine synthase activity
KM388_RS11595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM388_RS11610	COG0596	Alpha beta hydrolase
KM388_RS11615	COG2814	Major facilitator Superfamily
KM388_RS11635	COG2226	methyltransferase
KM388_RS11680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM388_RS11715	COG1247	-acetyltransferase
KM388_RS11745	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM388_RS11755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM388_RS11765	COG1278	Cold shock
KM388_RS11780	COG0010	Belongs to the arginase family
KM388_RS11785	COG0561	phosphatase activity
KM388_RS11825	COG0583	DNA-binding transcription factor activity
KM388_RS11830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM388_RS11845	COG0583	DNA-binding transcription factor activity
KM388_RS11850	COG2258	MOSC domain
KM388_RS11865	COG1132	(ABC) transporter
KM388_RS11870	COG1132	(ABC) transporter
KM388_RS11890	COG1396	sequence-specific DNA binding
KM388_RS11915	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KM388_RS11920	COG1595	DNA-templated transcription, initiation
KM388_RS11945	COG1649	PFAM Uncharacterised BCR, COG1649
KM388_RS11970	COG2971	BadF BadG BcrA BcrD
KM388_RS11975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM388_RS11980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM388_RS12000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM388_RS12030	COG1309	transcriptional regulator
KM388_RS12045	COG1136	(ABC) transporter
KM388_RS12045	COG0577	efflux transmembrane transporter activity
KM388_RS12050	COG3615	Tellurite resistance protein tehB
KM388_RS12050	COG0500	methyltransferase
KM388_RS12060	COG2226	methyltransferase
KM388_RS12065	COG3961	Belongs to the TPP enzyme family
KM388_RS12070	COG1846	Transcriptional regulator
KM388_RS12110	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM388_RS12125	COG1595	DNA-templated transcription, initiation
KM388_RS12135	COG0768	penicillin binding
KM388_RS12140	COG0768	penicillin binding
KM388_RS12145	COG2367	Beta-lactamase
KM388_RS12150	COG0671	phosphoesterase, PA-phosphatase related
KM388_RS12155	COG1609	Transcriptional regulator
KM388_RS12160	COG2814	Major facilitator Superfamily
KM388_RS12165	COG0673	inositol 2-dehydrogenase activity
KM388_RS12175	COG1012	belongs to the aldehyde dehydrogenase family
KM388_RS12190	COG0191	fructose-bisphosphate aldolase activity
KM388_RS12210	COG0737	Belongs to the 5'-nucleotidase family
KM388_RS12225	COG1476	TRANSCRIPTIONal
KM388_RS12240	COG1876	peptidase activity
KM388_RS12260	COG1309	transcriptional regulator
KM388_RS12265	COG0488	(ABC) transporter
KM388_RS12280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM388_RS12300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM388_RS12315	COG1131	(ABC) transporter
KM388_RS12325	COG1309	transcriptional regulator
KM388_RS12340	COG1960	acyl-CoA dehydrogenase activity
KM388_RS12345	COG0439	Biotin carboxylase
KM388_RS12350	COG0511	ligase activity, forming carbon-carbon bonds
KM388_RS12355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KM388_RS12360	COG1024	Enoyl-CoA hydratase
KM388_RS12365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KM388_RS12370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM388_RS12380	COG1247	-acetyltransferase
KM388_RS12385	COG0572	uridine kinase
KM388_RS12395	COG2318	DinB family
KM388_RS12400	COG1686	Belongs to the peptidase S11 family
KM388_RS12425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KM388_RS12465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM388_RS12465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM388_RS12490	COG2814	Major facilitator Superfamily
KM388_RS12505	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM388_RS12525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM388_RS12540	COG1063	alcohol dehydrogenase
KM388_RS12555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM388_RS12560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM388_RS12575	COG3773	Cell wall hydrolase
KM388_RS12585	COG0745	RESPONSE REGULATOR receiver
KM388_RS12600	COG0488	(ABC) transporter
KM388_RS12615	COG1136	(ABC) transporter
KM388_RS12640	COG0460	homoserine dehydrogenase
KM388_RS12645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM388_RS12655	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM388_RS12725	COG2124	cytochrome p450
KM388_RS12760	COG0561	phosphatase activity
KM388_RS12770	COG0768	penicillin binding
KM388_RS12775	COG1819	glycosyl
KM388_RS12780	COG1794	racemase activity, acting on amino acids and derivatives
KM388_RS12790	COG1122	ATPase activity
KM388_RS12805	COG2205	protein histidine kinase activity
KM388_RS12815	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM388_RS12820	COG0604	alcohol dehydrogenase
KM388_RS12825	COG0768	penicillin binding
KM388_RS12835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM388_RS12870	COG0693	protein deglycase activity
KM388_RS12900	COG2814	Major facilitator Superfamily
KM388_RS12915	COG0584	glycerophosphoryl diester phosphodiesterase
KM388_RS12935	COG0697	spore germination
KM388_RS12965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM388_RS12975	COG2223	nitrite transmembrane transporter activity
KM388_RS12990	COG2816	NAD+ diphosphatase activity
KM388_RS12995	COG0592	DNA-directed DNA polymerase activity
KM388_RS13000	COG1051	belongs to the nudix hydrolase family
KM388_RS13035	COG3878	Protein conserved in bacteria
KM388_RS13085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM388_RS13100	COG0322	excinuclease ABC activity
KM388_RS13140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM388_RS13165	COG1011	Hydrolase
KM388_RS13180	COG0657	acetylesterase activity
KM388_RS13185	COG0076	glutamate decarboxylase activity
KM388_RS13200	COG1523	belongs to the glycosyl hydrolase 13 family
KM388_RS13205	COG3227	Zinc metalloprotease (Elastase)
KM388_RS13225	COG0201	protein transport
KM388_RS13235	COG0697	spore germination
KM388_RS13240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM388_RS13270	COG4129	membrane
KM388_RS13275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM388_RS13290	COG2959	enzyme of heme biosynthesis
KM388_RS13310	COG3483	tryptophan 2,3-dioxygenase activity
KM388_RS13315	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KM388_RS13320	COG3844	kynureninase activity
KM388_RS13325	COG1309	transcriptional regulator
KM388_RS13355	COG3284	Transcriptional regulator
KM388_RS13375	COG1349	DNA-binding transcription factor activity
KM388_RS13395	COG1959	2 iron, 2 sulfur cluster binding
KM388_RS13410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM388_RS13415	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM388_RS13420	COG0022	dehydrogenase e1 component
KM388_RS13425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM388_RS13435	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS13440	COG0456	acetyltransferase
KM388_RS13440	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM388_RS13470	COG4176	ABC-type proline glycine betaine transport system permease component
KM388_RS13475	COG4175	Glycine betaine
KM388_RS13475	COG0517	IMP dehydrogenase activity
KM388_RS13500	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KM388_RS13505	COG2153	protein acetylation
KM388_RS13510	COG3397	chitin binding
KM388_RS13525	COG2205	protein histidine kinase activity
KM388_RS13550	COG2333	competence protein COMEC
KM388_RS13550	COG0658	competence protein
KM388_RS13600	COG3973	AAA domain
KM388_RS13615	COG2105	PFAM AIG2 family protein
KM388_RS13620	COG0514	ATP-dependent DNA helicase (RecQ)
KM388_RS13640	COG4637	Psort location Cytoplasmic, score
KM388_RS13665	COG3397	chitin binding
KM388_RS13680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KM388_RS13685	COG1115	amino acid carrier protein
KM388_RS13690	COG1012	belongs to the aldehyde dehydrogenase family
KM388_RS13695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM388_RS13705	COG3938	Belongs to the proline racemase family
KM388_RS13710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM388_RS13750	COG0586	Pfam SNARE associated Golgi protein
KM388_RS13765	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM388_RS13770	COG0519	Catalyzes the synthesis of GMP from XMP
KM388_RS13775	COG4166	transmembrane transport
KM388_RS13785	COG4948	Mandelate Racemase Muconate Lactonizing
KM388_RS13830	COG2936	dipeptidyl-peptidase activity
KM388_RS13835	COG5002	protein histidine kinase activity
KM388_RS13840	COG0745	RESPONSE REGULATOR receiver
KM388_RS13885	COG1307	EDD domain protein, DegV family
KM388_RS13905	COG2814	Major facilitator Superfamily
KM388_RS13915	COG1664	Polymer-forming cytoskeletal
KM388_RS13920	COG0789	Transcriptional regulator
KM388_RS13925	COG4533	DNA binding
KM388_RS13930	COG2814	Major facilitator Superfamily
KM388_RS13930	COG0477	Major facilitator Superfamily
KM388_RS13950	COG2261	transglycosylase associated protein
KM388_RS13965	COG2226	methyltransferase
KM388_RS14000	COG0436	Aminotransferase
KM388_RS14005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KM388_RS14010	COG5146	pantothenate kinase activity
KM388_RS14030	COG1131	(ABC) transporter
KM388_RS14075	COG0628	permease
KM388_RS14090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM388_RS14095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM388_RS14100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM388_RS14105	COG1116	anion transmembrane transporter activity
KM388_RS14125	COG2816	NAD+ diphosphatase activity
KM388_RS14145	COG2746	aminoglycoside 3-N-acetyltransferase activity
KM388_RS14170	COG0697	spore germination
KM388_RS14175	COG2318	DinB family
KM388_RS14215	COG0861	Integral membrane protein TerC family
KM388_RS14220	COG1368	sulfuric ester hydrolase activity
KM388_RS14225	COG0488	(ABC) transporter
KM388_RS14240	COG1309	transcriptional regulator
KM388_RS14255	COG0287	Prephenate dehydrogenase
KM388_RS14260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM388_RS14265	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KM388_RS14270	COG1605	Chorismate mutase
KM388_RS14270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KM388_RS14305	COG3584	3D domain protein
KM388_RS14305	COG1388	LysM domain
KM388_RS14315	COG1595	DNA-templated transcription, initiation
KM388_RS14340	COG1879	ABC-type sugar transport system periplasmic component
KM388_RS14350	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM388_RS14360	COG2390	Transcriptional regulator
KM388_RS14365	COG1070	Carbohydrate kinase
KM388_RS14395	COG2329	Antibiotic biosynthesis monooxygenase
KM388_RS14415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM388_RS14425	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KM388_RS14430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM388_RS14435	COG4187	Peptidase family M20/M25/M40
KM388_RS14440	COG1414	Transcriptional regulator
KM388_RS14445	COG0833	amino acid
KM388_RS14450	COG1690	Belongs to the RtcB family
KM388_RS14455	COG3239	Fatty acid desaturase
KM388_RS14460	COG1785	Belongs to the alkaline phosphatase family
KM388_RS14470	COG3655	Transcriptional regulator
KM388_RS14485	COG4377	Putative membrane peptidase family (DUF2324)
KM388_RS14495	COG3279	Response regulator of the LytR AlgR family
KM388_RS14505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM388_RS14510	COG0346	lactoylglutathione lyase activity
KM388_RS14530	COG0714	Associated with various cellular activities
KM388_RS14575	COG0463	Glycosyl transferase, family 2
KM388_RS14585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM388_RS14590	COG0753	catalase activity
KM388_RS14600	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KM388_RS14625	COG0714	Associated with various cellular activities
KM388_RS14635	COG0778	Nitroreductase
KM388_RS14640	COG1846	Transcriptional regulator
KM388_RS14675	COG1725	Transcriptional regulator
KM388_RS14685	COG1136	(ABC) transporter
KM388_RS14685	COG0577	efflux transmembrane transporter activity
KM388_RS14710	COG2207	Transcriptional regulator
KM388_RS14715	COG0456	acetyltransferase
KM388_RS14735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM388_RS14755	COG0642	Histidine kinase
KM388_RS14760	COG0745	RESPONSE REGULATOR receiver
KM388_RS14765	COG0596	Alpha beta hydrolase
KM388_RS14795	COG0730	response to heat
KM388_RS14805	COG0833	amino acid
KM388_RS14815	COG4335	DNA alkylation repair
KM388_RS14855	COG0768	penicillin binding
KM388_RS14865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KM388_RS14900	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KM388_RS14905	COG1414	Transcriptional regulator
KM388_RS14920	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM388_RS14925	COG0640	Transcriptional regulator
KM388_RS14935	COG1960	acyl-CoA dehydrogenase activity
KM388_RS14950	COG3314	Sporulation integral membrane protein YlbJ
KM388_RS14965	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KM388_RS14980	COG3848	Pyruvate phosphate dikinase
KM388_RS14980	COG0574	Belongs to the PEP-utilizing enzyme family
KM388_RS14985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM388_RS15000	COG5577	PFAM Coat F domain
KM388_RS15005	COG3403	YqcI/YcgG family
KM388_RS15010	COG1280	lysine exporter protein (LysE YggA)
KM388_RS15045	COG1063	alcohol dehydrogenase
KM388_RS15060	COG1027	Aspartate ammonia-lyase
KM388_RS15065	COG0252	asparaginase activity
KM388_RS15070	COG1396	sequence-specific DNA binding
KM388_RS15080	COG0322	excinuclease ABC activity
KM388_RS15085	COG0531	amino acid
KM388_RS15090	COG1114	Component of the transport system for branched-chain amino acids
KM388_RS15095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM388_RS15105	COG0281	malic enzyme
KM388_RS15120	COG0531	amino acid
KM388_RS15130	COG0784	Response regulator, receiver
KM388_RS15140	COG2066	Belongs to the glutaminase family
KM388_RS15145	COG1115	amino acid carrier protein
KM388_RS15175	COG0737	Belongs to the 5'-nucleotidase family
KM388_RS15180	COG0753	catalase activity
KM388_RS15185	COG2267	carboxylic ester hydrolase activity
KM388_RS15190	COG1335	isochorismatase
KM388_RS15210	COG0583	DNA-binding transcription factor activity
KM388_RS15220	COG0598	Magnesium transport protein CorA
KM388_RS15260	COG0415	Belongs to the DNA photolyase family
KM388_RS15265	COG0288	reversible hydration of carbon dioxide
KM388_RS15275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM388_RS15280	COG5609	conserved protein (DUF2294)
KM388_RS15295	COG1575	Belongs to the MenA family. Type 1 subfamily
KM388_RS15300	COG2267	carboxylic ester hydrolase activity
KM388_RS15305	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM388_RS15310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM388_RS15315	COG1121	(ABC) transporter
KM388_RS15345	COG0798	PFAM Bile acid sodium symporter
KM388_RS15350	COG0346	lactoylglutathione lyase activity
KM388_RS15355	COG0640	Transcriptional regulator
KM388_RS15370	COG0443	Heat shock 70 kDa protein
KM388_RS15385	COG1522	sequence-specific DNA binding
KM388_RS15400	COG0346	lactoylglutathione lyase activity
KM388_RS15420	COG2169	Transcriptional regulator
KM388_RS15465	COG2814	Major facilitator Superfamily
KM388_RS15490	COG0745	RESPONSE REGULATOR receiver
KM388_RS15495	COG5002	protein histidine kinase activity
KM388_RS15495	COG3850	Histidine kinase
KM388_RS15520	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KM388_RS15540	COG1476	TRANSCRIPTIONal
KM388_RS15555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM388_RS15560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM388_RS15570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM388_RS15575	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KM388_RS15590	COG1136	(ABC) transporter
KM388_RS15595	COG0577	efflux transmembrane transporter activity
KM388_RS15610	COG3850	Histidine kinase
KM388_RS15610	COG5002	protein histidine kinase activity
KM388_RS15620	COG2364	Membrane
KM388_RS15625	COG1846	Transcriptional regulator
KM388_RS15635	COG2808	Putative FMN-binding domain
KM388_RS15640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM388_RS15645	COG2271	Major facilitator Superfamily
KM388_RS15650	COG1556	Lactate utilization protein
KM388_RS15655	COG1139	Iron-sulfur cluster binding protein
KM388_RS15665	COG0583	DNA-binding transcription factor activity
KM388_RS15680	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM388_RS15705	COG0673	inositol 2-dehydrogenase activity
KM388_RS15710	COG0561	phosphatase activity
KM388_RS15720	COG1609	Transcriptional regulator
KM388_RS15725	COG0457	Tetratricopeptide repeat
KM388_RS15775	COG0534	Mate efflux family protein
KM388_RS15795	COG2814	Major facilitator Superfamily
KM388_RS15800	COG1309	transcriptional regulator
KM388_RS15815	COG0814	amino acid
KM388_RS15820	COG1760	l-serine dehydratase
KM388_RS15825	COG1760	l-serine dehydratase
KM388_RS15835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM388_RS15840	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KM388_RS15855	COG1522	sequence-specific DNA binding
KM388_RS15860	COG0531	amino acid
KM388_RS15880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KM388_RS15900	COG1595	DNA-templated transcription, initiation
KM388_RS15915	COG0662	Cupin 2, conserved barrel domain protein
KM388_RS15920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM388_RS15920	COG2207	Transcriptional regulator
KM388_RS15970	COG0477	Major facilitator Superfamily
KM388_RS15980	COG1846	Transcriptional regulator
KM388_RS15985	COG2814	Major facilitator Superfamily
KM388_RS15995	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM388_RS16000	COG1131	(ABC) transporter
KM388_RS16020	COG2076	Multidrug Resistance protein
KM388_RS16025	COG1309	transcriptional regulator
KM388_RS16035	COG2031	fatty acid transporter
KM388_RS16045	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM388_RS16075	COG1122	ATPase activity
KM388_RS16080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM388_RS16095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KM388_RS16100	COG1288	antiporter activity
KM388_RS16105	COG2356	endonuclease I
KM388_RS16120	COG3620	sequence-specific DNA binding
KM388_RS16125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM388_RS16130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KM388_RS16135	COG0124	histidyl-tRNA synthetase
KM388_RS16150	COG1733	regulation of RNA biosynthetic process
KM388_RS16155	COG0778	Nitroreductase
KM388_RS16175	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS16185	COG1131	(ABC) transporter
KM388_RS16210	COG1011	Hydrolase
KM388_RS16220	COG2365	Tyrosine phosphatase family
KM388_RS16245	COG0346	lactoylglutathione lyase activity
KM388_RS16250	COG1940	carbohydrate kinase activity
KM388_RS16255	COG0738	Major facilitator superfamily
KM388_RS16260	COG0110	maltose O-acetyltransferase activity
KM388_RS16270	COG0577	efflux transmembrane transporter activity
KM388_RS16270	COG1136	(ABC) transporter
KM388_RS16285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KM388_RS16290	COG0628	permease
KM388_RS16310	COG2226	methyltransferase
KM388_RS16320	COG0477	Major facilitator Superfamily
KM388_RS16350	COG1253	flavin adenine dinucleotide binding
KM388_RS16355	COG0789	Transcriptional regulator
KM388_RS16360	COG0697	spore germination
KM388_RS16365	COG1357	PFAM Pentapeptide repeats (8 copies)
KM388_RS16370	COG3813	Protein conserved in bacteria
KM388_RS16375	COG2706	6-phosphogluconolactonase activity
KM388_RS16380	COG1070	Carbohydrate kinase
KM388_RS16390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KM388_RS16395	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KM388_RS16410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM388_RS16415	COG0604	alcohol dehydrogenase
KM388_RS16420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM388_RS16430	COG0604	alcohol dehydrogenase
KM388_RS16430	COG3321	synthase
KM388_RS16435	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS16460	COG0656	L-ascorbic acid biosynthetic process
KM388_RS16465	COG2814	Major facilitator Superfamily
KM388_RS16480	COG0346	lactoylglutathione lyase activity
KM388_RS16485	COG0814	amino acid
KM388_RS16510	COG1393	Belongs to the ArsC family
KM388_RS16515	COG1733	regulation of RNA biosynthetic process
KM388_RS16520	COG2188	Transcriptional regulator
KM388_RS16525	COG0673	inositol 2-dehydrogenase activity
KM388_RS16530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KM388_RS16535	COG1733	regulation of RNA biosynthetic process
KM388_RS16540	COG1733	regulation of RNA biosynthetic process
KM388_RS16555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM388_RS16575	COG0384	phenazine biosynthesis protein PhzF
KM388_RS16585	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS16595	COG0318	PFAM AMP-dependent synthetase and ligase
KM388_RS16605	COG1733	regulation of RNA biosynthetic process
KM388_RS16635	COG1191	sigma factor activity
KM388_RS16650	COG1309	transcriptional regulator
KM388_RS16670	COG3152	Membrane
KM388_RS16695	COG1151	hydroxylamine reductase activity
KM388_RS16705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM388_RS16710	COG3757	hydrolase, family 25
KM388_RS16710	COG3409	Peptidoglycan-binding domain 1 protein
KM388_RS16745	COG2072	flavoprotein involved in K transport
KM388_RS16780	COG0604	alcohol dehydrogenase
KM388_RS16785	COG1113	amino acid transport
KM388_RS16790	COG2814	Major facilitator Superfamily
KM388_RS16820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM388_RS16825	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM388_RS16850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM388_RS16855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM388_RS16860	COG3739	integral membrane protein
KM388_RS16865	COG0384	phenazine biosynthesis protein PhzF
KM388_RS16895	COG0583	DNA-binding transcription factor activity
KM388_RS16915	COG1193	negative regulation of DNA recombination
KM388_RS16930	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KM388_RS16935	COG1164	Oligoendopeptidase f
KM388_RS16940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM388_RS16970	COG0584	glycerophosphoryl diester phosphodiesterase
KM388_RS16995	COG0640	Transcriptional regulator
KM388_RS17000	COG0604	alcohol dehydrogenase
KM388_RS17020	COG2808	Putative FMN-binding domain
KM388_RS17035	COG0385	Bile acid
KM388_RS17040	COG0277	FAD linked oxidase domain protein
KM388_RS17070	COG1216	Glycosyl transferase, family 2
KM388_RS17075	COG1024	Enoyl-CoA hydratase
KM388_RS17085	COG1285	pathogenesis
KM388_RS17100	COG2514	catechol 2,3-dioxygenase activity
KM388_RS17105	COG2720	vancomycin resistance protein
KM388_RS17145	COG0716	FMN binding
KM388_RS17175	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS17200	COG4145	pantothenate transmembrane transporter activity
KM388_RS17210	COG1012	belongs to the aldehyde dehydrogenase family
KM388_RS17215	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS17225	COG1657	PFAM Prenyltransferase squalene oxidase
KM388_RS17230	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KM388_RS17235	COG2962	Rard protein
KM388_RS17240	COG3326	Membrane
KM388_RS17255	COG0489	protein tyrosine kinase activity
KM388_RS17265	COG0314	molybdopterin synthase activity
KM388_RS17270	COG0303	'Molybdopterin
KM388_RS17275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM388_RS17280	COG2116	formate transmembrane transporter activity
KM388_RS17290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM388_RS17295	COG5609	conserved protein (DUF2294)
KM388_RS17300	COG2427	Protein of unknown function (DUF1641)
KM388_RS17315	COG0697	spore germination
KM388_RS17355	COG2226	methyltransferase
KM388_RS17360	COG4166	transmembrane transport
KM388_RS17365	COG4166	transmembrane transport
KM388_RS17370	COG1301	dicarboxylic acid transport
KM388_RS17375	COG1316	TRANSCRIPTIONal
KM388_RS17385	COG1595	DNA-templated transcription, initiation
KM388_RS17405	COG1131	(ABC) transporter
KM388_RS17415	COG0673	inositol 2-dehydrogenase activity
KM388_RS17420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM388_RS17425	COG0187	DNA topoisomerase II activity
KM388_RS17430	COG1832	CoA-binding protein
KM388_RS17435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM388_RS17440	COG0745	RESPONSE REGULATOR receiver
KM388_RS17455	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM388_RS17460	COG4841	protein insertion into membrane
KM388_RS17465	COG0824	Thioesterase
KM388_RS17495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM388_RS17505	COG2274	protein secretion by the type I secretion system
KM388_RS17510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KM388_RS17550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM388_RS17565	COG0183	Belongs to the thiolase family
KM388_RS17570	COG0318	PFAM AMP-dependent synthetase and ligase
KM388_RS17575	COG1268	BioY protein
KM388_RS17580	COG0318	PFAM AMP-dependent synthetase and ligase
KM388_RS17630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM388_RS17645	COG0400	carboxylic ester hydrolase activity
KM388_RS17650	COG0346	lactoylglutathione lyase activity
KM388_RS17655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM388_RS17660	COG0069	glutamate synthase activity
KM388_RS17665	COG1902	pentaerythritol trinitrate reductase activity
KM388_RS17670	COG1329	Transcriptional regulator
KM388_RS17675	COG0010	Belongs to the arginase family
KM388_RS17700	COG2226	methyltransferase
KM388_RS17735	COG4846	Membrane protein involved in cytochrome C biogenesis
KM388_RS17740	COG0785	Cytochrome C biogenesis protein
KM388_RS17750	COG0583	DNA-binding transcription factor activity
KM388_RS17755	COG1380	Effector of murein hydrolase LrgA
KM388_RS17760	COG1346	cytolysis
KM388_RS17785	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM388_RS17785	COG3409	Peptidoglycan-binding domain 1 protein
KM388_RS17800	COG1132	(ABC) transporter
KM388_RS17805	COG1132	(ABC) transporter
KM388_RS17835	COG3639	organic phosphonate transmembrane transporter activity
KM388_RS17840	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KM388_RS17860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KM388_RS17880	COG1695	Transcriptional regulator
KM388_RS17920	COG1388	LysM domain
KM388_RS17920	COG3409	Peptidoglycan-binding domain 1 protein
KM388_RS17920	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM388_RS17925	COG4824	toxin secretion phage lysis holin
KM388_RS18070	COG1595	DNA-templated transcription, initiation
KM388_RS18115	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KM388_RS18195	COG1396	sequence-specific DNA binding
KM388_RS18220	COG0174	glutamine synthetase
KM388_RS18225	COG0789	Transcriptional regulator
KM388_RS18230	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KM388_RS18235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM388_RS18240	COG2860	membrane
KM388_RS18245	COG0464	growth
KM388_RS18275	COG3584	3D domain protein
KM388_RS18275	COG1388	LysM domain
KM388_RS18280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM388_RS18280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM388_RS18280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM388_RS18285	COG1105	Belongs to the carbohydrate kinase PfkB family
KM388_RS18290	COG1349	DNA-binding transcription factor activity
KM388_RS18300	COG2322	membrane
KM388_RS18310	COG1113	amino acid transport
KM388_RS18325	COG1408	metallophosphoesterase
KM388_RS18330	COG2116	formate transmembrane transporter activity
KM388_RS18340	COG2217	Heavy metal translocating P-type atpase
KM388_RS18345	COG2608	mercury ion transmembrane transporter activity
KM388_RS18350	COG1937	Protein conserved in bacteria
KM388_RS18360	COG2819	hydrolase of the alpha beta superfamily
KM388_RS18365	COG1120	ATPase activity
KM388_RS18370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM388_RS18375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM388_RS18390	COG2169	Transcriptional regulator
KM388_RS18395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM388_RS18400	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM388_RS18410	COG2364	Membrane
KM388_RS18425	COG2267	carboxylic ester hydrolase activity
KM388_RS18430	COG0346	lactoylglutathione lyase activity
KM388_RS18455	COG1346	cytolysis
KM388_RS18460	COG1380	Effector of murein hydrolase LrgA
KM388_RS18465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM388_RS18470	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM388_RS18470	COG0596	Alpha beta hydrolase
KM388_RS18475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM388_RS18495	COG1404	Belongs to the peptidase S8 family
KM388_RS18500	COG3773	Cell wall hydrolase
KM388_RS18505	COG0562	UDP-galactopyranose mutase
KM388_RS18510	COG1368	sulfuric ester hydrolase activity
KM388_RS18515	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM388_RS18525	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KM388_RS18550	COG1131	(ABC) transporter
KM388_RS18570	COG4550	Control of competence regulator ComK, YlbF/YmcA
KM388_RS18575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM388_RS18580	COG1013	pyruvate-flavodoxin oxidoreductase activity
KM388_RS18585	COG0674	pyruvate-flavodoxin oxidoreductase activity
KM388_RS18585	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KM388_RS18595	COG2359	stage V sporulation protein S
KM388_RS18600	COG1692	metallophosphoesterase
KM388_RS18625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM388_RS18630	COG1426	Protein conserved in bacteria
KM388_RS18645	COG0300	oxidoreductase activity
KM388_RS18650	COG0612	Peptidase, M16
KM388_RS18655	COG0612	Peptidase, M16
KM388_RS18660	COG1079	Belongs to the binding-protein-dependent transport system permease family
KM388_RS18670	COG3845	ABC transporter
KM388_RS18675	COG1744	ABC transporter substrate-binding protein PnrA-like
KM388_RS18680	COG2188	Transcriptional regulator
KM388_RS18685	COG1674	ftsk spoiiie
KM388_RS18695	COG0740	serine-type endopeptidase activity
KM388_RS18700	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM388_RS18710	COG0527	aspartate kinase activity
KM388_RS18715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM388_RS18720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM388_RS18725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM388_RS18730	COG1873	PFAM PRC-barrel domain
KM388_RS18735	COG0612	Peptidase, M16
KM388_RS18740	COG0726	polysaccharide deacetylase
KM388_RS18755	COG0196	riboflavin kinase activity
KM388_RS18760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KM388_RS18770	COG1550	Protein conserved in bacteria
KM388_RS18780	COG1358	cellular component organization or biogenesis
KM388_RS18785	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KM388_RS18790	COG0195	Participates in both transcription termination and antitermination
KM388_RS18810	COG0750	zinc metalloprotease
KM388_RS18820	COG4589	Belongs to the CDS family
KM388_RS18835	COG0528	UMP kinase activity
KM388_RS18865	COG4974	Belongs to the 'phage' integrase family
KM388_RS18875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM388_RS18885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KM388_RS18925	COG1837	Belongs to the UPF0109 family
KM388_RS18935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KM388_RS18945	COG0552	protein localization to endoplasmic reticulum
KM388_RS18950	COG1196	nuclear chromosome segregation
KM388_RS18960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM388_RS18965	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS18970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KM388_RS18985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KM388_RS18990	COG1461	Dihydroxyacetone kinase
KM388_RS18995	COG1302	Protein conserved in bacteria
KM388_RS19010	COG1564	THIamine pyrophosphokinase
KM388_RS19015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KM388_RS19020	COG1162	GTPase activity
KM388_RS19025	COG0515	serine threonine protein kinase
KM388_RS19025	COG2815	serine threonine protein kinase
KM388_RS19030	COG0631	protein serine/threonine phosphatase activity
KM388_RS19040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KM388_RS19040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM388_RS19050	COG0242	peptide deformylase activity
KM388_RS19055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KM388_RS19060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM388_RS19080	COG1561	YicC-like family, N-terminal region
KM388_RS19085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KM388_RS19095	COG0006	proline dipeptidase activity
KM388_RS19110	COG3069	C4-dicarboxylate transmembrane transporter activity
KM388_RS19175	COG0564	pseudouridine synthase activity
KM388_RS19195	COG3599	regulation of cell shape
KM388_RS19200	COG2302	S4 RNA-binding domain
KM388_RS19205	COG0762	integral membrane protein
KM388_RS19215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KM388_RS19220	COG1496	oxidoreductase activity
KM388_RS19225	COG1873	PFAM PRC-barrel domain
KM388_RS19230	COG1191	sigma factor activity
KM388_RS19235	COG1191	sigma factor activity
KM388_RS19245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KM388_RS19250	COG0849	cell division
KM388_RS19255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KM388_RS19260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM388_RS19270	COG0772	Belongs to the SEDS family
KM388_RS19285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM388_RS19290	COG0768	penicillin binding
KM388_RS19295	COG0768	penicillin binding
KM388_RS19300	COG4839	cell division protein FtsL
KM388_RS19315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM388_RS19330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KM388_RS19335	COG1399	metal-binding, possibly nucleic acid-binding protein
KM388_RS19385	COG4824	toxin secretion phage lysis holin
KM388_RS19475	COG1802	Transcriptional regulator
KM388_RS19475	COG4626	Terminase
KM388_RS19500	COG0582	viral genome integration into host DNA
KM388_RS19565	COG0756	dUTP diphosphatase activity
KM388_RS19585	COG1191	sigma factor activity
KM388_RS19610	COG1484	DNA-dependent DNA replication
KM388_RS19635	COG1396	sequence-specific DNA binding
KM388_RS19650	COG1396	sequence-specific DNA binding
KM388_RS19665	COG0582	viral genome integration into host DNA
KM388_RS19675	COG3480	Lon protease (S16) C-terminal proteolytic domain
KM388_RS19680	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM388_RS19685	COG3314	Sporulation integral membrane protein YlbJ
KM388_RS19695	COG0742	ribosomal rna small subunit methyltransferase
KM388_RS19710	COG3679	Belongs to the UPF0342 family
KM388_RS19715	COG0406	alpha-ribazole phosphatase activity
KM388_RS19730	COG2340	Cysteine-rich secretory protein family
KM388_RS19745	COG3336	cytochrome c oxidase
KM388_RS19780	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KM388_RS19785	COG0772	Belongs to the SEDS family
KM388_RS19795	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KM388_RS19800	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KM388_RS19810	COG4896	Protein conserved in bacteria
KM388_RS19825	COG1217	gtp-binding protein TYPA
KM388_RS19835	COG0483	inositol monophosphate 1-phosphatase activity
KM388_RS19855	COG1982	Orn Lys Arg decarboxylase major
KM388_RS19905	COG0022	dehydrogenase e1 component
KM388_RS19910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM388_RS19920	COG0242	peptide deformylase activity
KM388_RS19935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM388_RS19940	COG0569	domain protein
KM388_RS19960	COG0583	DNA-binding transcription factor activity
KM388_RS19965	COG0517	IMP dehydrogenase activity
KM388_RS19975	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KM388_RS19985	COG4703	Protein of unknown function (DUF1797)
KM388_RS20000	COG2200	EAL domain
KM388_RS20005	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS20010	COG1408	metallophosphoesterase
KM388_RS20055	COG2814	Major facilitator Superfamily
KM388_RS20075	COG3209	COG3209 Rhs family protein
KM388_RS20085	COG2205	protein histidine kinase activity
KM388_RS20095	COG0436	Aminotransferase
KM388_RS20100	COG1609	Transcriptional regulator
KM388_RS20105	COG3833	ABC-type maltose transport systems, permease component
KM388_RS20110	COG1175	transmembrane transport
KM388_RS20115	COG2182	Extracellular solute-binding protein
KM388_RS20125	COG0366	Alpha amylase catalytic
KM388_RS20130	COG3842	ATPase activity
KM388_RS20170	COG0183	Belongs to the thiolase family
KM388_RS20205	COG1695	Transcriptional regulator
KM388_RS20210	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS20220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KM388_RS20230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM388_RS20235	COG0436	Aminotransferase
KM388_RS20255	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KM388_RS20275	COG2199	diguanylate cyclase activity
KM388_RS20280	COG0778	Nitroreductase
KM388_RS20305	COG1263	PTS System
KM388_RS20305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM388_RS20305	COG2190	(PTS) system
KM388_RS20310	COG3711	transcriptional antiterminator
KM388_RS20320	COG2188	Transcriptional regulator
KM388_RS20330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KM388_RS20355	COG1547	Domain of unknown function (DUF309)
KM388_RS20360	COG0456	acetyltransferase
KM388_RS20370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KM388_RS20375	COG4086	secreted protein
KM388_RS20380	COG0561	phosphatase activity
KM388_RS20385	COG0697	spore germination
KM388_RS20400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM388_RS20425	COG0733	neurotransmitter:sodium symporter activity
KM388_RS20445	COG1686	Belongs to the peptidase S11 family
KM388_RS20450	COG1725	Transcriptional regulator
KM388_RS20455	COG1131	(ABC) transporter
KM388_RS20470	COG1846	Transcriptional regulator
KM388_RS20485	COG0598	Magnesium transport protein CorA
KM388_RS20510	COG4974	Belongs to the 'phage' integrase family
KM388_RS20520	COG0735	belongs to the Fur family
KM388_RS20525	COG1300	Membrane
KM388_RS20545	COG0667	Aldo Keto reductase
KM388_RS20550	COG0656	L-ascorbic acid biosynthetic process
KM388_RS20555	COG0456	acetyltransferase
KM388_RS20555	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM388_RS20565	COG0737	Belongs to the 5'-nucleotidase family
KM388_RS20565	COG4085	toxin activity
KM388_RS20565	COG1525	nuclease
KM388_RS20575	COG0596	Alpha beta hydrolase
KM388_RS20580	COG2056	Na+-H+ antiporter family
KM388_RS20585	COG1609	Transcriptional regulator
KM388_RS20590	COG0456	acetyltransferase
KM388_RS20595	COG1073	alpha beta
KM388_RS20610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM388_RS20610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM388_RS20615	COG0307	riboflavin synthase, alpha
KM388_RS20640	COG4106	trans-aconitate 2-methyltransferase activity
KM388_RS20645	COG1073	alpha beta
KM388_RS20645	COG2226	methyltransferase
KM388_RS20660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM388_RS20670	COG1757	Na H antiporter
KM388_RS20675	COG0737	Belongs to the 5'-nucleotidase family
KM388_RS20685	COG1522	sequence-specific DNA binding
KM388_RS20705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM388_RS20715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KM388_RS20730	COG0300	oxidoreductase activity
KM388_RS20735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM388_RS20740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM388_RS20745	COG1760	l-serine dehydratase
KM388_RS20750	COG1760	l-serine dehydratase
KM388_RS20770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM388_RS20780	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM388_RS20785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM388_RS20800	COG1376	ErfK ybiS ycfS ynhG family protein
KM388_RS20805	COG4129	membrane
KM388_RS20810	COG1126	abc transporter atp-binding protein
KM388_RS20815	COG0765	amino acid transport
KM388_RS20820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM388_RS20835	COG2816	NAD+ diphosphatase activity
KM388_RS20840	COG0772	Belongs to the SEDS family
KM388_RS20845	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM388_RS20850	COG0022	dehydrogenase e1 component
KM388_RS20855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM388_RS20860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM388_RS20875	COG0280	phosphate acetyltransferase
KM388_RS20880	COG3290	protein histidine kinase activity
KM388_RS20880	COG3829	transcription factor binding
KM388_RS20890	COG0584	glycerophosphoryl diester phosphodiesterase
KM388_RS20895	COG3093	addiction module antidote protein HigA
KM388_RS20905	COG0745	RESPONSE REGULATOR receiver
KM388_RS20910	COG0750	zinc metalloprotease
KM388_RS20915	COG0497	DNA recombination
KM388_RS20925	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KM388_RS20935	COG0142	geranyltranstransferase activity
KM388_RS20960	COG1302	Protein conserved in bacteria
KM388_RS20965	COG0439	Biotin carboxylase
KM388_RS20970	COG0511	ligase activity, forming carbon-carbon bonds
KM388_RS21015	COG3854	ATPases associated with a variety of cellular activities
KM388_RS21040	COG0006	proline dipeptidase activity
KM388_RS21055	COG3872	metal-dependent enzyme
KM388_RS21065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM388_RS21085	COG0095	Lipoate-protein ligase
KM388_RS21090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM388_RS21095	COG1609	Transcriptional regulator
KM388_RS21105	COG2076	Multidrug Resistance protein
KM388_RS21110	COG2076	Multidrug Resistance protein
KM388_RS21145	COG1131	(ABC) transporter
KM388_RS21150	COG1725	Transcriptional regulator
KM388_RS21180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM388_RS21235	COG4970	Tfp pilus assembly protein FimT
KM388_RS21240	COG4537	Required for transformation and DNA binding
KM388_RS21245	COG1459	type II secretion system
KM388_RS21250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM388_RS21300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KM388_RS21310	COG0646	methionine synthase
KM388_RS21310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KM388_RS21315	COG0626	cystathionine gamma-synthase activity
KM388_RS21320	COG0626	cystathionine gamma-synthase activity
KM388_RS21340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM388_RS21350	COG1940	carbohydrate kinase activity
KM388_RS21355	COG4483	Protein conserved in bacteria
KM388_RS21360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KM388_RS21365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KM388_RS21370	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KM388_RS21375	COG0704	Plays a role in the regulation of phosphate uptake
KM388_RS21385	COG0581	inorganic phosphate transmembrane transporter activity
KM388_RS21390	COG0573	inorganic phosphate transmembrane transporter activity
KM388_RS21395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM388_RS21400	COG0768	penicillin binding
KM388_RS21405	COG0477	Major facilitator Superfamily
KM388_RS21410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM388_RS21435	COG0735	belongs to the Fur family
KM388_RS21440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM388_RS21445	COG1121	(ABC) transporter
KM388_RS21450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM388_RS21480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM388_RS21485	COG2384	SAM-dependent methyltransferase
KM388_RS21490	COG2010	Cytochrome c
KM388_RS21495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM388_RS21500	COG0358	DNA primase activity
KM388_RS21510	COG0517	IMP dehydrogenase activity
KM388_RS21525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KM388_RS21530	COG0295	cytidine deaminase activity
KM388_RS21535	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KM388_RS21545	COG1480	7TM receptor with intracellular HD hydrolase
KM388_RS21550	COG1702	phosphate starvation-inducible protein PhoH
KM388_RS21565	COG1610	YqeY-like protein
KM388_RS21570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KM388_RS21575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM388_RS21580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KM388_RS21610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM388_RS21615	COG1733	regulation of RNA biosynthetic process
KM388_RS21640	COG1466	dna polymerase III delta subunit
KM388_RS21655	COG2131	deaminase
KM388_RS21660	COG1596	polysaccharide export
KM388_RS21660	COG1555	photosystem II stabilization
KM388_RS21665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM388_RS21670	COG2226	methyltransferase
KM388_RS21675	COG0799	negative regulation of ribosome biogenesis
KM388_RS21680	COG1713	HD superfamily hydrolase involved in NAD metabolism
KM388_RS21690	COG1534	Rna-binding protein
KM388_RS21700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KM388_RS21705	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KM388_RS21730	COG1595	DNA-templated transcription, initiation
KM388_RS21740	COG0778	Nitroreductase
KM388_RS21745	COG2357	RelA SpoT domain protein
KM388_RS21755	COG1785	Belongs to the alkaline phosphatase family
KM388_RS21765	COG2267	carboxylic ester hydrolase activity
KM388_RS21800	COG1404	Belongs to the peptidase S8 family
KM388_RS21805	COG3186	Phenylalanine-4-hydroxylase
KM388_RS21815	COG2514	catechol 2,3-dioxygenase activity
KM388_RS21820	COG2259	Doxx family
KM388_RS21860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM388_RS21870	COG1012	belongs to the aldehyde dehydrogenase family
KM388_RS21870	COG1454	alcohol dehydrogenase
KM388_RS21875	COG0626	cystathionine gamma-synthase activity
KM388_RS21880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM388_RS21905	COG0768	penicillin binding
KM388_RS21920	COG0826	peptidase U32
KM388_RS21925	COG0826	peptidase U32
KM388_RS21930	COG4122	O-methyltransferase activity
KM388_RS21935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KM388_RS21955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM388_RS21965	COG0628	permease
KM388_RS21985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM388_RS21995	COG0482	sulfurtransferase activity
KM388_RS22000	COG1104	cysteine desulfurase activity
KM388_RS22005	COG1959	2 iron, 2 sulfur cluster binding
KM388_RS22010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KM388_RS22020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KM388_RS22045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM388_RS22055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KM388_RS22055	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KM388_RS22060	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM388_RS22065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM388_RS22065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM388_RS22075	COG2244	polysaccharide biosynthetic process
KM388_RS22080	COG2323	membrane
KM388_RS22090	COG1862	Preprotein translocase
KM388_RS22120	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KM388_RS22130	COG0697	spore germination
KM388_RS22135	COG0697	spore germination
KM388_RS22140	COG0640	Transcriptional regulator
KM388_RS22165	COG0157	Belongs to the NadC ModD family
KM388_RS22170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KM388_RS22175	COG1104	cysteine desulfurase activity
KM388_RS22180	COG1827	regulation of RNA biosynthetic process
KM388_RS22185	COG2258	MOSC domain
KM388_RS22190	COG0077	Prephenate dehydratase
KM388_RS22195	COG0577	efflux transmembrane transporter activity
KM388_RS22200	COG0577	efflux transmembrane transporter activity
KM388_RS22205	COG1136	(ABC) transporter
KM388_RS22220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KM388_RS22225	COG3290	protein histidine kinase activity
KM388_RS22235	COG2868	ribosomal protein
KM388_RS22245	COG1530	ribonuclease E activity
KM388_RS22250	COG1994	Peptidase M50
KM388_RS22255	COG0739	heme binding
KM388_RS22260	COG2894	cell division
KM388_RS22280	COG1077	Cell shape determining protein MreB Mrl
KM388_RS22300	COG0285	dihydrofolate synthase activity
KM388_RS22305	COG0525	valine-tRNA ligase activity
KM388_RS22315	COG1388	LysM domain
KM388_RS22325	COG0113	porphobilinogen synthase activity
KM388_RS22330	COG1587	Uroporphyrinogen-III synthase
KM388_RS22340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM388_RS22350	COG1846	Transcriptional regulator
KM388_RS22355	COG1764	response to oxidative stress
KM388_RS22370	COG0470	DNA polymerase III
KM388_RS22370	COG1067	ATP-dependent peptidase activity
KM388_RS22415	COG0622	Phosphoesterase
KM388_RS22430	COG5401	PFAM Sporulation and spore germination
KM388_RS22450	COG1309	transcriptional regulator
KM388_RS22465	COG2197	response regulator
KM388_RS22470	COG2233	PERMEase
KM388_RS22480	COG0402	S-adenosylhomocysteine deaminase activity
KM388_RS22485	COG0402	S-adenosylhomocysteine deaminase activity
KM388_RS22495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM388_RS22505	COG0444	Belongs to the ABC transporter superfamily
KM388_RS22510	COG4608	Belongs to the ABC transporter superfamily
KM388_RS22515	COG3275	phosphorelay sensor kinase activity
KM388_RS22520	COG3279	Response regulator of the LytR AlgR family
KM388_RS22535	COG1983	PspC domain protein
KM388_RS22540	COG1396	sequence-specific DNA binding
KM388_RS22545	COG0697	spore germination
KM388_RS22555	COG1959	2 iron, 2 sulfur cluster binding
KM388_RS22560	COG1668	transmembrane transport
KM388_RS22570	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KM388_RS22580	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM388_RS22585	COG1876	peptidase activity
KM388_RS22590	COG0824	Thioesterase
KM388_RS22595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KM388_RS22600	COG1053	succinate dehydrogenase
KM388_RS22605	COG2009	succinate dehydrogenase
KM388_RS22610	COG1719	4-vinyl reductase, 4VR
KM388_RS22620	COG3118	belongs to the thioredoxin family
KM388_RS22625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KM388_RS22630	COG2086	electron transfer activity
KM388_RS22635	COG1024	Enoyl-CoA hydratase
KM388_RS22640	COG1309	transcriptional regulator
KM388_RS22645	COG0318	PFAM AMP-dependent synthetase and ligase
KM388_RS22665	COG2318	DinB family
KM388_RS22695	COG1131	(ABC) transporter
KM388_RS22700	COG2205	protein histidine kinase activity
KM388_RS22705	COG0745	RESPONSE REGULATOR receiver
KM388_RS22715	COG4895	conserved protein (DUF2196)
KM388_RS22720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KM388_RS22735	COG4509	Sortase family
KM388_RS22740	COG1120	ATPase activity
KM388_RS22755	COG5386	Cell surface protein
KM388_RS22765	COG5386	Cell surface protein
KM388_RS22770	COG1114	Component of the transport system for branched-chain amino acids
KM388_RS22775	COG1187	pseudouridine synthase activity
KM388_RS22785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM388_RS22785	COG1796	DNA polymerase
KM388_RS22790	COG1286	toxin biosynthetic process
KM388_RS22835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM388_RS22845	COG1418	mRNA catabolic process
KM388_RS22870	COG2814	Major facilitator Superfamily
KM388_RS22875	COG1566	PFAM secretion protein HlyD family protein
KM388_RS22880	COG1309	transcriptional regulator
KM388_RS22885	COG1363	Peptidase, m42
KM388_RS22910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM388_RS22920	COG1484	DNA-dependent DNA replication
KM388_RS22925	COG3611	Membrane attachment protein
KM388_RS22935	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM388_RS22940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM388_RS22945	COG0237	dephospho-CoA kinase activity
KM388_RS22950	COG1971	Probably functions as a manganese efflux pump
KM388_RS22960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM388_RS22960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM388_RS22965	COG5002	protein histidine kinase activity
KM388_RS22970	COG0745	RESPONSE REGULATOR receiver
KM388_RS22990	COG0538	isocitrate dehydrogenase activity
KM388_RS22995	COG0372	Belongs to the citrate synthase family
KM388_RS23005	COG0628	permease
KM388_RS23010	COG3030	protein affecting phage T7 exclusion by the F plasmid
KM388_RS23035	COG1725	Transcriptional regulator
KM388_RS23040	COG0281	malic enzyme
KM388_RS23045	COG0587	DNA-directed DNA polymerase activity
KM388_RS23060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KM388_RS23080	COG4109	DRTGG domain
KM388_RS23095	COG0006	proline dipeptidase activity
KM388_RS23135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM388_RS23140	COG0662	Cupin 2, conserved barrel domain protein
KM388_RS23150	COG1476	TRANSCRIPTIONal
KM388_RS23165	COG1028	Short-chain dehydrogenase reductase Sdr
KM388_RS23170	COG0589	response to stress
KM388_RS23210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM388_RS23230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KM388_RS23235	COG0827	DNA restriction-modification system
KM388_RS23240	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KM388_RS23245	COG3874	Sporulation protein YtfJ
KM388_RS23260	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KM388_RS23270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM388_RS23285	COG1104	cysteine desulfurase activity
KM388_RS23295	COG0583	DNA-binding transcription factor activity
KM388_RS23300	COG0697	spore germination
KM388_RS23310	COG1956	GAF domain-containing protein
KM388_RS23315	COG0626	cystathionine gamma-synthase activity
KM388_RS23345	COG1595	DNA-templated transcription, initiation
KM388_RS23355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM388_RS23360	COG0454	-acetyltransferase
KM388_RS23365	COG0517	IMP dehydrogenase activity
KM388_RS23370	COG0123	including yeast histone deacetylase and acetoin utilization protein
KM388_RS23380	COG0745	RESPONSE REGULATOR receiver
KM388_RS23390	COG0666	response to abiotic stimulus
KM388_RS23425	COG1609	Transcriptional regulator
KM388_RS23430	COG4851	CamS sex pheromone cAM373 precursor
KM388_RS23435	COG3118	belongs to the thioredoxin family
KM388_RS23445	COG2309	aminopeptidase activity
KM388_RS23465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM388_RS23480	COG1674	ftsk spoiiie
KM388_RS23490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM388_RS23495	COG4848	Belongs to the UPF0354 family
KM388_RS23500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM388_RS23505	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KM388_RS23510	COG1363	Peptidase, m42
KM388_RS23520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM388_RS23535	COG0510	thiamine kinase activity
KM388_RS23540	COG1523	belongs to the glycosyl hydrolase 13 family
KM388_RS23550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM388_RS23555	COG1349	DNA-binding transcription factor activity
KM388_RS23560	COG1187	pseudouridine synthase activity
KM388_RS23565	COG2244	polysaccharide biosynthetic process
KM388_RS23570	COG2081	HI0933 family
KM388_RS23575	COG2814	Major facilitator Superfamily
KM388_RS23585	COG3832	glyoxalase III activity
KM388_RS23615	COG4975	Glucose uptake
KM388_RS23630	COG0314	molybdopterin synthase activity
KM388_RS23635	COG1763	Mo-molybdopterin cofactor biosynthetic process
KM388_RS23640	COG0303	'Molybdopterin
KM388_RS23650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM388_RS23655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM388_RS23680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM388_RS23690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM388_RS23730	COG2814	Major facilitator Superfamily
KM388_RS23735	COG0475	glutathione-regulated potassium exporter activity
KM388_RS23740	COG0490	domain, Protein
KM388_RS23745	COG0582	viral genome integration into host DNA
KM388_RS23755	COG1136	(ABC) transporter
KM388_RS23775	COG1242	4 iron, 4 sulfur cluster binding
KM388_RS23780	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KM388_RS23785	COG1131	(ABC) transporter
KM388_RS23795	COG1794	racemase activity, acting on amino acids and derivatives
KM388_RS23815	COG2267	carboxylic ester hydrolase activity
KM388_RS23820	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM388_RS23825	COG0671	phosphoesterase, PA-phosphatase related
KM388_RS23830	COG0438	transferase activity, transferring glycosyl groups
KM388_RS23840	COG0521	Mo-molybdopterin cofactor biosynthetic process
KM388_RS23895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM388_RS23900	COG5002	protein histidine kinase activity
KM388_RS23905	COG4191	Histidine kinase
KM388_RS23910	COG2267	carboxylic ester hydrolase activity
KM388_RS23930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM388_RS23935	COG1116	anion transmembrane transporter activity
KM388_RS23940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM388_RS23965	COG0494	nUDIX hydrolase
KM388_RS24000	COG0288	reversible hydration of carbon dioxide
KM388_RS24005	COG1271	oxidase subunit
KM388_RS24010	COG1294	oxidase, subunit
KM388_RS24030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM388_RS24055	COG1842	Phage shock protein A
KM388_RS24085	COG5002	protein histidine kinase activity
KM388_RS24090	COG0745	RESPONSE REGULATOR receiver
KM388_RS24115	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM388_RS24120	COG1597	lipid kinase activity
KM388_RS24155	COG0586	Pfam SNARE associated Golgi protein
KM388_RS24165	COG0577	efflux transmembrane transporter activity
KM388_RS24170	COG1136	(ABC) transporter
KM388_RS24180	COG0745	RESPONSE REGULATOR receiver
KM388_RS24185	COG2205	protein histidine kinase activity
KM388_RS24190	COG0577	efflux transmembrane transporter activity
KM388_RS24195	COG0577	efflux transmembrane transporter activity
KM388_RS24200	COG1136	(ABC) transporter
KM388_RS24220	COG2188	Transcriptional regulator
KM388_RS24240	COG3964	amidohydrolase
KM388_RS24270	COG4948	Mandelate Racemase Muconate Lactonizing
KM388_RS24280	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KM388_RS24285	COG0596	Alpha beta hydrolase
KM388_RS24290	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KM388_RS24295	COG1169	isochorismate synthase
KM388_RS24300	COG1575	Belongs to the MenA family. Type 1 subfamily
KM388_RS24305	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KM388_RS24325	COG0058	SHG alpha-glucan phosphorylase activity
KM388_RS24330	COG0297	glycogen (starch) synthase activity
KM388_RS24335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KM388_RS24450	COG0544	peptidyl-prolyl cis-trans isomerase activity
KM388_RS24485	COG1285	pathogenesis
KM388_RS24490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM388_RS24500	COG0166	Belongs to the GPI family
KM388_RS24505	COG2155	Conserved Protein
KM388_RS24510	COG1098	S1 RNA binding domain
KM388_RS24515	COG0436	Aminotransferase
KM388_RS24520	COG1522	sequence-specific DNA binding
KM388_RS24525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM388_RS24530	COG2267	carboxylic ester hydrolase activity
KM388_RS24540	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KM388_RS24560	COG5018	Exonuclease
KM388_RS24565	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM388_RS24585	COG2050	protein possibly involved in aromatic compounds catabolism
KM388_RS24595	COG1268	BioY protein
KM388_RS24605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM388_RS24610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KM388_RS24625	COG3584	3D domain protein
KM388_RS24640	COG1252	NADH dehydrogenase
KM388_RS24655	COG3708	Transcriptional regulator
KM388_RS24670	COG1683	Conserved Protein
KM388_RS24690	COG0316	Belongs to the HesB IscA family
KM388_RS24705	COG1252	NADH dehydrogenase
KM388_RS24715	COG2274	protein secretion by the type I secretion system
KM388_RS24720	COG0390	transport system, permease component
KM388_RS24725	COG2824	Alkylphosphonate utilization operon protein PhnA
KM388_RS24765	COG4837	Protein of unknown function (DUF1462)
KM388_RS24770	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KM388_RS24780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM388_RS24785	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KM388_RS24795	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM388_RS24800	COG0647	UMP catabolic process
KM388_RS24810	COG2445	Protein of unknown function DUF86
KM388_RS24815	COG1494	fructose-1,6-bisphosphatase
KM388_RS24830	COG4470	Protein conserved in bacteria
KM388_RS24840	COG0789	Transcriptional regulator
KM388_RS24845	COG4377	Putative membrane peptidase family (DUF2324)
KM388_RS24870	COG0739	heme binding
KM388_RS24880	COG3377	Domain of unknown function (DUF1805)
KM388_RS24885	COG0737	Belongs to the 5'-nucleotidase family
KM388_RS24890	COG1695	Transcriptional regulator
KM388_RS24900	COG0719	Fe-S assembly protein
KM388_RS24905	COG0822	iron-sulfur transferase activity
KM388_RS24910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KM388_RS24915	COG0719	Fe-S assembly protein
KM388_RS24920	COG0396	ATPase activity
KM388_RS24925	COG1464	Belongs to the NlpA lipoprotein family
KM388_RS24930	COG1464	Belongs to the NlpA lipoprotein family
KM388_RS24935	COG2011	ABC-type metal ion transport system permease component
KM388_RS24940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM388_RS24950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM388_RS24955	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM388_RS24965	COG1393	Belongs to the ArsC family
KM388_RS25010	COG0039	L-malate dehydrogenase activity
KM388_RS25035	COG1309	transcriptional regulator
KM388_RS25040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM388_RS25045	COG1960	acyl-CoA dehydrogenase activity
KM388_RS25050	COG0183	Belongs to the thiolase family
KM388_RS25055	COG1024	Enoyl-CoA hydratase
KM388_RS25055	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM388_RS25065	COG1686	Belongs to the peptidase S11 family
KM388_RS25080	COG0011	TIGRFAM Protein of
KM388_RS25085	COG0840	transmembrane signaling receptor activity
KM388_RS25105	COG2814	Major facilitator Superfamily
KM388_RS25110	COG0531	amino acid
KM388_RS25120	COG0706	membrane insertase activity
KM388_RS25130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM388_RS25165	COG0586	Pfam SNARE associated Golgi protein
KM388_RS25175	COG1376	ErfK ybiS ycfS ynhG family protein
KM388_RS25180	COG0745	RESPONSE REGULATOR receiver
KM388_RS25185	COG5002	protein histidine kinase activity
KM388_RS25210	COG2151	metal-sulfur cluster biosynthetic enzyme
KM388_RS25215	COG3227	Zinc metalloprotease (Elastase)
KM388_RS25220	COG1741	Belongs to the pirin family
KM388_RS25235	COG0475	glutathione-regulated potassium exporter activity
KM388_RS25240	COG0490	domain, Protein
KM388_RS25245	COG1115	amino acid carrier protein
KM388_RS25250	COG0783	Belongs to the Dps family
KM388_RS25265	COG1611	Belongs to the LOG family
KM388_RS25285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM388_RS25290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM388_RS25295	COG1115	amino acid carrier protein
KM388_RS25300	COG1115	amino acid carrier protein
KM388_RS25305	COG2910	NAD(P)H-binding
KM388_RS25320	COG0656	L-ascorbic acid biosynthetic process
KM388_RS25325	COG2814	Major facilitator Superfamily
KM388_RS25330	COG1733	regulation of RNA biosynthetic process
KM388_RS25340	COG1252	NADH dehydrogenase
KM388_RS25345	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KM388_RS25350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM388_RS25360	COG3290	protein histidine kinase activity
KM388_RS25360	COG0840	transmembrane signaling receptor activity
KM388_RS25370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM388_RS25375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM388_RS25390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM388_RS25445	COG0557	exoribonuclease II activity
KM388_RS25450	COG1647	Serine aminopeptidase, S33
KM388_RS25455	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM388_RS25460	COG1346	cytolysis
KM388_RS25560	COG4695	Portal protein
KM388_RS25580	COG4974	Belongs to the 'phage' integrase family
KM388_RS25595	COG0149	triose-phosphate isomerase activity
KM388_RS25605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM388_RS25620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KM388_RS25645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM388_RS25660	COG2323	membrane
KM388_RS25665	COG0740	serine-type endopeptidase activity
KM388_RS25670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM388_RS25680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KM388_RS25690	COG1051	belongs to the nudix hydrolase family
KM388_RS25700	COG0492	ferredoxin-NADP+ reductase activity
KM388_RS25705	COG0457	Tetratricopeptide repeat
KM388_RS25710	COG0110	maltose O-acetyltransferase activity
KM388_RS25730	COG1950	PFAM Membrane protein of
KM388_RS25740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM388_RS25745	COG0556	nucleotide-excision repair
KM388_RS25765	COG0789	Transcriptional regulator
KM388_RS25790	COG2855	membrane
KM388_RS25795	COG0583	DNA-binding transcription factor activity
KM388_RS25805	COG0655	NAD(P)H dehydrogenase (quinone) activity
KM388_RS25810	COG0488	(ABC) transporter
KM388_RS25820	COG1132	(ABC) transporter
KM388_RS25825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM388_RS25830	COG3409	Peptidoglycan-binding domain 1 protein
KM388_RS25830	COG0793	Belongs to the peptidase S41A family
KM388_RS25835	COG2177	Part of the ABC transporter FtsEX involved in
KM388_RS25840	COG2884	Cell division ATP-binding protein ftsE
KM388_RS25855	COG0653	protein targeting
KM388_RS25860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KM388_RS25865	COG1278	Cold shock
KM388_RS25870	COG1040	competence protein
KM388_RS25880	COG1388	LysM domain
KM388_RS25880	COG0791	NLP P60 protein
KM388_RS25885	COG1733	regulation of RNA biosynthetic process
KM388_RS25890	COG1307	EDD domain protein, DegV family
KM388_RS25895	COG1739	Uncharacterized protein family UPF0029
KM388_RS25900	COG1316	TRANSCRIPTIONal
KM388_RS25905	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM388_RS25910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM388_RS25915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KM388_RS25925	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KM388_RS25925	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KM388_RS25940	COG3394	polysaccharide catabolic process
KM388_RS25945	COG1486	melibiose metabolic process
KM388_RS25950	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM388_RS25955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM388_RS25965	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KM388_RS25970	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM388_RS25975	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM388_RS25985	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM388_RS25990	COG1301	dicarboxylic acid transport
KM388_RS26000	COG0346	lactoylglutathione lyase activity
KM388_RS26005	COG1511	domain protein
KM388_RS26010	COG0583	DNA-binding transcription factor activity
KM388_RS26015	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KM388_RS26030	COG1271	oxidase subunit
KM388_RS26035	COG1294	oxidase, subunit
KM388_RS26040	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM388_RS26050	COG1620	l-lactate permease
KM388_RS26060	COG2389	metal-binding protein
KM388_RS26070	COG1368	sulfuric ester hydrolase activity
KM388_RS26085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM388_RS26095	COG1215	transferase activity, transferring glycosyl groups
KM388_RS26100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM388_RS26105	COG3584	3D domain protein
KM388_RS26105	COG1388	LysM domain
KM388_RS26130	COG4715	Zinc finger, swim domain protein
KM388_RS26135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM388_RS26175	COG0577	efflux transmembrane transporter activity
KM388_RS26180	COG1136	(ABC) transporter
KM388_RS26215	COG5002	protein histidine kinase activity
KM388_RS26220	COG0745	RESPONSE REGULATOR receiver
KM388_RS26225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM388_RS26245	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM388_RS26250	COG1134	teichoic acid transport
KM388_RS26255	COG1682	transport, permease protein
KM388_RS26260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KM388_RS26305	COG1609	Transcriptional regulator
KM388_RS26320	COG0739	heme binding
KM388_RS26340	COG2385	sporulation resulting in formation of a cellular spore
KM388_RS26355	COG4836	Membrane
KM388_RS26360	COG1007	ATP synthesis coupled electron transport
KM388_RS26365	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM388_RS26370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM388_RS26380	COG0839	Belongs to the complex I subunit 6 family
KM388_RS26395	COG0649	NAD binding
KM388_RS26400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM388_RS26415	COG3300	MHYT domain
KM388_RS26415	COG5001	Diguanylate cyclase
KM388_RS26465	COG0356	it plays a direct role in the translocation of protons across the membrane
KM388_RS26500	COG0698	ribose 5-phosphate isomerase
KM388_RS26510	COG2190	(PTS) system
KM388_RS26515	COG2259	Doxx family
KM388_RS26520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KM388_RS26535	COG0009	L-threonylcarbamoyladenylate synthase
KM388_RS26550	COG2890	protein-(glutamine-N5) methyltransferase activity
KM388_RS26570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KM388_RS26575	COG1494	fructose-1,6-bisphosphatase
KM388_RS26595	COG4821	SIS domain
KM388_RS26605	COG3343	RNA polymerase activity
KM388_RS26615	COG1960	acyl-CoA dehydrogenase activity
KM388_RS26620	COG1960	acyl-CoA dehydrogenase activity
KM388_RS26625	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM388_RS26630	COG0183	Belongs to the thiolase family
KM388_RS26635	COG2181	nitrate reductase activity
KM388_RS26635	COG0247	lactate metabolic process
KM388_RS26640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM388_RS26650	COG5001	Diguanylate cyclase
KM388_RS26650	COG3300	MHYT domain
KM388_RS26670	COG2197	response regulator
KM388_RS26675	COG4585	Histidine kinase
KM388_RS26680	COG0842	Transport permease protein
KM388_RS26685	COG1131	(ABC) transporter
KM388_RS26690	COG0024	Methionine aminopeptidase
KM388_RS26700	COG2234	aminopeptidase activity
KM388_RS26720	COG1595	DNA-templated transcription, initiation
KM388_RS26725	COG0018	arginyl-trna synthetase
KM388_RS26730	COG4506	Protein conserved in bacteria
KM388_RS26735	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM388_RS26750	COG0010	Belongs to the arginase family
KM388_RS26760	COG2814	Major facilitator Superfamily
KM388_RS26765	COG0789	Transcriptional regulator
KM388_RS26770	COG0584	glycerophosphoryl diester phosphodiesterase
KM388_RS26775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM388_RS26785	COG1994	Peptidase M50
KM388_RS26795	COG1078	dGTPase activity
KM388_RS26800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM388_RS26805	COG1120	ATPase activity
KM388_RS26810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM388_RS26815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM388_RS26835	COG0095	Lipoate-protein ligase
KM388_RS26840	COG0280	phosphate acetyltransferase
KM388_RS26855	COG3773	Cell wall hydrolase
KM388_RS26865	COG2363	Small membrane protein
KM388_RS26875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM388_RS26880	COG2233	PERMEase
KM388_RS26885	COG0561	phosphatase activity
KM388_RS26890	COG2814	Major facilitator Superfamily
KM388_RS26900	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM388_RS26905	COG1131	(ABC) transporter
KM388_RS26910	COG2755	lipolytic protein G-D-S-L family
KM388_RS26915	COG1609	Transcriptional regulator
KM388_RS26925	COG0460	homoserine dehydrogenase
KM388_RS26935	COG2873	o-acetylhomoserine
KM388_RS26945	COG1011	Hydrolase
KM388_RS26950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM388_RS26960	COG2197	response regulator
KM388_RS26970	COG0351	phosphomethylpyrimidine kinase
KM388_RS26975	COG3706	GGDEF domain
KM388_RS26980	COG2879	small protein
KM388_RS26985	COG1966	Carbon starvation protein
KM388_RS26990	COG3279	Response regulator of the LytR AlgR family
KM388_RS26995	COG0477	Major facilitator Superfamily
KM388_RS27030	COG1607	acyl-coa hydrolase
KM388_RS27045	COG0488	(ABC) transporter
KM388_RS27065	COG0463	Glycosyl transferase, family 2
KM388_RS27070	COG1309	transcriptional regulator
KM388_RS27075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM388_RS27080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM388_RS27080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM388_RS27085	COG0628	permease
KM388_RS27100	COG3279	Response regulator of the LytR AlgR family
KM388_RS27105	COG3275	phosphorelay sensor kinase activity
KM388_RS27110	COG2814	Major facilitator Superfamily
KM388_RS27115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM388_RS27120	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KM388_RS27125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM388_RS27145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM388_RS27150	COG1272	protein, Hemolysin III
KM388_RS27175	COG1164	Oligoendopeptidase f
KM388_RS27195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM388_RS27200	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KM388_RS27205	COG4853	Protein conserved in bacteria
KM388_RS27210	COG4863	YycH protein
KM388_RS27215	COG5002	protein histidine kinase activity
KM388_RS27220	COG0745	RESPONSE REGULATOR receiver
KM388_RS27250	COG0305	Participates in initiation and elongation during chromosome replication
KM388_RS27260	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KM388_RS27265	COG4241	membrane
KM388_RS27275	COG0629	single-stranded DNA binding
KM388_RS27285	COG0012	GTP binding
KM388_RS27290	COG4481	Protein conserved in bacteria
KM388_RS27295	COG0668	transmembrane transport
KM388_RS27305	COG1475	DNA binding
KM388_RS27310	COG1192	Involved in chromosome partitioning
KM388_RS27335	COG1847	R3H domain protein
KM388_RS27340	COG0706	membrane insertase activity
KM388_RS27350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KM388_RS27405	COG3344	reverse transcriptase
KM388_RS27490	COG3344	reverse transcriptase
KM388_RS27825	COG2311	Membrane
KM388_RS27845	COG4196	transglutaminase domain protein
KM388_RS27850	COG0671	phosphoesterase, PA-phosphatase related
KM388_RS27870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM388_RS27875	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM388_RS28040	COG2002	toxin-antitoxin pair type II binding
KM388_RS28050	COG4974	Belongs to the 'phage' integrase family
KM388_RS28110	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM388_RS28115	COG4974	Belongs to the 'phage' integrase family
KM388_RS28140	COG0457	Tetratricopeptide repeat
KM388_RS28465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM388_RS28475	COG4166	transmembrane transport
KM388_RS28520	COG1280	lysine exporter protein (LysE YggA)
KM388_RS28555	COG0681	Belongs to the peptidase S26 family
KM388_RS28630	COG1309	transcriptional regulator
KM388_RS28635	COG1683	Conserved Protein
KM388_RS28680	COG1192	Involved in chromosome partitioning