locus-tag	class	description
A8C77_RS00165	COG1774	PSP1 C-terminal conserved region
A8C77_RS00275	COG3956	TIGRFAM MazG family protein
A8C77_RS00350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A8C77_RS00455	COG1045	serine acetyltransferase
A8C77_RS00690	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A8C77_RS00760	COG2610	gluconate transmembrane transporter activity
A8C77_RS00765	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8C77_RS00825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8C77_RS01340	COG0592	DNA-directed DNA polymerase activity
A8C77_RS01345	COG2501	S4 domain
A8C77_RS01355	COG0187	DNA topoisomerase II activity
A8C77_RS01360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8C77_RS01395	COG0516	GMP reductase activity
A8C77_RS01395	COG0517	IMP dehydrogenase activity
A8C77_RS01400	COG1686	Belongs to the peptidase S11 family
A8C77_RS01430	COG1428	Deoxynucleoside kinase
A8C77_RS01435	COG1428	Deoxynucleoside kinase
A8C77_RS01440	COG1335	isochorismatase
A8C77_RS01450	COG0590	tRNA wobble adenosine to inosine editing
A8C77_RS01460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A8C77_RS01515	COG1982	Orn Lys Arg decarboxylase major
A8C77_RS01525	COG0470	DNA polymerase III
A8C77_RS01530	COG1774	PSP1 C-terminal conserved region
A8C77_RS01540	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A8C77_RS01550	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A8C77_RS01555	COG2002	toxin-antitoxin pair type II binding
A8C77_RS01560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8C77_RS01560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8C77_RS01565	COG0084	hydrolase, TatD family'
A8C77_RS01570	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A8C77_RS01585	COG4466	Protein conserved in bacteria
A8C77_RS01600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8C77_RS01605	COG0251	oxidation-reduction process
A8C77_RS01635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A8C77_RS01640	COG2002	toxin-antitoxin pair type II binding
A8C77_RS01645	COG2244	polysaccharide biosynthetic process
A8C77_RS01650	COG3956	TIGRFAM MazG family protein
A8C77_RS01655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A8C77_RS01675	COG1098	S1 RNA binding domain
A8C77_RS01690	COG2208	phosphoserine phosphatase activity
A8C77_RS01695	COG0037	tRNA processing
A8C77_RS01700	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A8C77_RS01705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8C77_RS01720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8C77_RS01725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A8C77_RS01730	COG0512	Glutamine amidotransferase of anthranilate synthase
A8C77_RS01735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8C77_RS01740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A8C77_RS01745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A8C77_RS01750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A8C77_RS01755	COG1396	sequence-specific DNA binding
A8C77_RS01760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8C77_RS01790	COG3880	PFAM UvrB UvrC protein
A8C77_RS01800	COG0542	response to heat
A8C77_RS01805	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A8C77_RS01815	COG4956	integral membrane protein (PIN domain superfamily)
A8C77_RS01835	COG1045	serine acetyltransferase
A8C77_RS01850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8C77_RS01855	COG3688	RNA-binding protein containing a PIN domain
A8C77_RS01870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8C77_RS01875	COG0250	Participates in transcription elongation, termination and antitermination
A8C77_RS01880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A8C77_RS01900	COG2813	Specifically methylates the guanine in position
A8C77_RS01910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A8C77_RS01915	COG1358	cellular component organization or biogenesis
A8C77_RS01985	COG0255	Belongs to the universal ribosomal protein uL29 family
A8C77_RS02045	COG0201	protein transport
A8C77_RS02055	COG0024	Methionine aminopeptidase
A8C77_RS02065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A8C77_RS02100	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8C77_RS02125	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8C77_RS02130	COG0489	protein tyrosine kinase activity
A8C77_RS02140	COG2194	sulfuric ester hydrolase activity
A8C77_RS02145	COG0726	polysaccharide deacetylase
A8C77_RS02230	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A8C77_RS02235	COG4856	YbbR-like protein
A8C77_RS02250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8C77_RS02255	COG0596	Alpha beta hydrolase
A8C77_RS02275	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8C77_RS02280	COG0823	Involved in the tonB-independent uptake of proteins
A8C77_RS02280	COG1506	peptidase
A8C77_RS02280	COG4946	Tricorn protease homolog
A8C77_RS02315	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS02320	COG2011	ABC-type metal ion transport system permease component
A8C77_RS02325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8C77_RS02330	COG1464	Belongs to the NlpA lipoprotein family
A8C77_RS02335	COG0604	alcohol dehydrogenase
A8C77_RS02345	COG0277	FAD linked oxidase domain protein
A8C77_RS02350	COG2271	Major facilitator Superfamily
A8C77_RS02360	COG2814	Major facilitator Superfamily
A8C77_RS02375	COG0601	transmembrane transport
A8C77_RS02380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C77_RS02385	COG0444	Belongs to the ABC transporter superfamily
A8C77_RS02390	COG4608	Belongs to the ABC transporter superfamily
A8C77_RS02395	COG4166	transmembrane transport
A8C77_RS02405	COG2207	Transcriptional regulator
A8C77_RS02420	COG4166	transmembrane transport
A8C77_RS02425	COG4166	transmembrane transport
A8C77_RS02430	COG0656	L-ascorbic acid biosynthetic process
A8C77_RS02435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8C77_RS02455	COG4149	molybdate abc transporter
A8C77_RS02460	COG0725	ABC transporter, periplasmic molybdate-binding protein
A8C77_RS02465	COG0725	ABC transporter, periplasmic molybdate-binding protein
A8C77_RS02470	COG1910	domain protein
A8C77_RS02485	COG0583	DNA-binding transcription factor activity
A8C77_RS02490	COG0697	spore germination
A8C77_RS02505	COG0204	Acyl-transferase
A8C77_RS02520	COG1609	Transcriptional regulator
A8C77_RS02530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8C77_RS02545	COG0084	hydrolase, TatD family'
A8C77_RS02550	COG5298	Protein conserved in bacteria
A8C77_RS02575	COG0488	(ABC) transporter
A8C77_RS02585	COG0747	negative chemotaxis
A8C77_RS02590	COG0601	transmembrane transport
A8C77_RS02595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C77_RS02600	COG0444	Belongs to the ABC transporter superfamily
A8C77_RS02605	COG4608	Belongs to the ABC transporter superfamily
A8C77_RS02630	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A8C77_RS02635	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8C77_RS02645	COG2814	Major facilitator Superfamily
A8C77_RS02660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A8C77_RS02670	COG4294	response to UV
A8C77_RS02675	COG0457	Tetratricopeptide repeat
A8C77_RS02675	COG0705	Rhomboid family
A8C77_RS02685	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A8C77_RS02690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8C77_RS02695	COG0864	Transcriptional regulator
A8C77_RS02700	COG2337	Toxic component of a toxin-antitoxin (TA) module
A8C77_RS02705	COG2183	response to ionizing radiation
A8C77_RS02800	COG0802	atpase or kinase
A8C77_RS02805	COG1214	PFAM Peptidase M22, glycoprotease
A8C77_RS02810	COG0456	acetyltransferase
A8C77_RS02820	COG0488	(ABC) transporter
A8C77_RS02835	COG1266	CAAX protease self-immunity
A8C77_RS02855	COG2252	PERMEase
A8C77_RS02865	COG5002	protein histidine kinase activity
A8C77_RS02895	COG2226	methyltransferase
A8C77_RS02935	COG1968	undecaprenyl-diphosphatase activity
A8C77_RS02950	COG2205	protein histidine kinase activity
A8C77_RS02955	COG0745	RESPONSE REGULATOR receiver
A8C77_RS02975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A8C77_RS02980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A8C77_RS02985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8C77_RS02995	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8C77_RS03010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A8C77_RS03020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A8C77_RS03030	COG0151	Belongs to the GarS family
A8C77_RS03055	COG0210	DNA helicase
A8C77_RS03065	COG4851	CamS sex pheromone cAM373 precursor
A8C77_RS03085	COG1335	isochorismatase
A8C77_RS03090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8C77_RS03095	COG2011	ABC-type metal ion transport system permease component
A8C77_RS03100	COG1464	Belongs to the NlpA lipoprotein family
A8C77_RS03120	COG1846	Transcriptional regulator
A8C77_RS03145	COG1597	lipid kinase activity
A8C77_RS03150	COG0546	phosphoglycolate phosphatase activity
A8C77_RS03155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8C77_RS03165	COG1012	belongs to the aldehyde dehydrogenase family
A8C77_RS03170	COG2076	Multidrug Resistance protein
A8C77_RS03175	COG2309	aminopeptidase activity
A8C77_RS03190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8C77_RS03195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8C77_RS03200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8C77_RS03210	COG4807	Protein conserved in bacteria
A8C77_RS03235	COG1757	Na H antiporter
A8C77_RS03240	COG1473	amidohydrolase
A8C77_RS03255	COG0450	alkyl hydroperoxide reductase
A8C77_RS03275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C77_RS03280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C77_RS03285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8C77_RS03305	COG0166	Belongs to the GPI family
A8C77_RS03340	COG5002	protein histidine kinase activity
A8C77_RS03360	COG3541	Predicted nucleotidyltransferase
A8C77_RS03365	COG2814	Major facilitator Superfamily
A8C77_RS03370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C77_RS03370	COG0723	plastoquinol--plastocyanin reductase activity
A8C77_RS03380	COG0765	amino acid transport
A8C77_RS03385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8C77_RS03400	COG0840	transmembrane signaling receptor activity
A8C77_RS03405	COG0840	transmembrane signaling receptor activity
A8C77_RS03410	COG0366	Alpha amylase catalytic
A8C77_RS03415	COG2190	(PTS) system
A8C77_RS03415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8C77_RS03415	COG1263	PTS System
A8C77_RS03445	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A8C77_RS03460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8C77_RS03470	COG1116	anion transmembrane transporter activity
A8C77_RS03475	COG0488	(ABC) transporter
A8C77_RS03520	COG2270	Major facilitator Superfamily
A8C77_RS03535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8C77_RS03550	COG2310	stress, protein
A8C77_RS03555	COG2310	stress, protein
A8C77_RS03560	COG2310	stress, protein
A8C77_RS03565	COG0861	Integral membrane protein TerC family
A8C77_RS03575	COG3853	Toxic anion resistance protein (TelA)
A8C77_RS03590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8C77_RS03600	COG1295	ribonuclease BN
A8C77_RS03605	COG2217	Heavy metal translocating P-type atpase
A8C77_RS03610	COG0697	spore germination
A8C77_RS03630	COG0586	Pfam SNARE associated Golgi protein
A8C77_RS03645	COG3871	stress protein (general stress protein 26)
A8C77_RS03650	COG0387	Pfam Sodium calcium exchanger
A8C77_RS03660	COG0535	radical SAM domain protein
A8C77_RS03685	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A8C77_RS03690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8C77_RS03695	COG0582	viral genome integration into host DNA
A8C77_RS03700	COG1396	sequence-specific DNA binding
A8C77_RS03715	COG1396	sequence-specific DNA binding
A8C77_RS03750	COG1484	DNA-dependent DNA replication
A8C77_RS03845	COG0582	viral genome integration into host DNA
A8C77_RS03850	COG0582	viral genome integration into host DNA
A8C77_RS03975	COG0101	tRNA pseudouridine synthase activity
A8C77_RS03985	COG3829	transcription factor binding
A8C77_RS03995	COG0833	amino acid
A8C77_RS04000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8C77_RS04035	COG1263	PTS System
A8C77_RS04035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8C77_RS04040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8C77_RS04055	COG0463	Glycosyl transferase, family 2
A8C77_RS04070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8C77_RS04070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8C77_RS04090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A8C77_RS04110	COG1228	amidohydrolase
A8C77_RS04115	COG1090	epimerase
A8C77_RS04145	COG1988	membrane-bound metal-dependent
A8C77_RS04150	COG1194	a g-specific adenine glycosylase
A8C77_RS04175	COG1132	(ABC) transporter
A8C77_RS04180	COG4129	membrane
A8C77_RS04185	COG0070	glutamate synthase
A8C77_RS04185	COG0069	glutamate synthase activity
A8C77_RS04185	COG0067	glutamate synthase
A8C77_RS04195	COG4555	ABC transporter
A8C77_RS04215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A8C77_RS04220	COG0735	belongs to the Fur family
A8C77_RS04335	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A8C77_RS04340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8C77_RS04350	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A8C77_RS04360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A8C77_RS04375	COG2766	serine protein kinase
A8C77_RS04400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8C77_RS04410	COG1585	Membrane protein implicated in regulation of membrane protease activity
A8C77_RS04415	COG2268	Band 7 protein
A8C77_RS04425	COG3290	protein histidine kinase activity
A8C77_RS04435	COG2851	Citrate transporter
A8C77_RS04455	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A8C77_RS04460	COG3842	ATPase activity
A8C77_RS04465	COG1175	transmembrane transport
A8C77_RS04470	COG0395	ABC-type sugar transport system, permease component
A8C77_RS04480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8C77_RS04485	COG0745	RESPONSE REGULATOR receiver
A8C77_RS04490	COG5002	protein histidine kinase activity
A8C77_RS04500	COG4990	cell redox homeostasis
A8C77_RS04510	COG3290	protein histidine kinase activity
A8C77_RS04515	COG4565	transcriptional regulatory protein
A8C77_RS04520	COG3493	citrate carrier protein
A8C77_RS04525	COG0281	malic enzyme
A8C77_RS04540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C77_RS04550	COG5002	protein histidine kinase activity
A8C77_RS04555	COG0745	RESPONSE REGULATOR receiver
A8C77_RS04565	COG0454	-acetyltransferase
A8C77_RS04565	COG0456	acetyltransferase
A8C77_RS04570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A8C77_RS04575	COG3383	formate dehydrogenase (NAD+) activity
A8C77_RS04580	COG2427	Protein of unknown function (DUF1641)
A8C77_RS04595	COG0531	amino acid
A8C77_RS04600	COG0640	Transcriptional regulator
A8C77_RS04605	COG2217	Heavy metal translocating P-type atpase
A8C77_RS04610	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A8C77_RS04620	COG3227	Zinc metalloprotease (Elastase)
A8C77_RS04640	COG2720	vancomycin resistance protein
A8C77_RS04645	COG1316	TRANSCRIPTIONal
A8C77_RS04650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8C77_RS04655	COG0346	lactoylglutathione lyase activity
A8C77_RS04660	COG1253	flavin adenine dinucleotide binding
A8C77_RS04665	COG1027	Aspartate ammonia-lyase
A8C77_RS04670	COG1620	l-lactate permease
A8C77_RS04685	COG3104	oligopeptide transport
A8C77_RS04690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8C77_RS04695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C77_RS04700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C77_RS04710	COG2226	methyltransferase
A8C77_RS04715	COG0156	8-amino-7-oxononanoate synthase activity
A8C77_RS04720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8C77_RS04730	COG4548	von Willebrand factor, type A
A8C77_RS04735	COG0714	Associated with various cellular activities
A8C77_RS04740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8C77_RS04760	COG0531	amino acid
A8C77_RS04765	COG2188	Transcriptional regulator
A8C77_RS04770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8C77_RS04770	COG1263	PTS System
A8C77_RS04775	COG0366	Alpha amylase catalytic
A8C77_RS04790	COG0697	spore germination
A8C77_RS04800	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8C77_RS04805	COG1115	amino acid carrier protein
A8C77_RS04810	COG1126	abc transporter atp-binding protein
A8C77_RS04815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8C77_RS04820	COG0765	amino acid transport
A8C77_RS04825	COG0765	amino acid transport
A8C77_RS04830	COG0833	amino acid
A8C77_RS04855	COG2378	regulation of single-species biofilm formation
A8C77_RS04860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8C77_RS04865	COG5002	protein histidine kinase activity
A8C77_RS04880	COG0659	secondary active sulfate transmembrane transporter activity
A8C77_RS04895	COG0747	negative chemotaxis
A8C77_RS04905	COG0601	transmembrane transport
A8C77_RS04910	COG4608	Belongs to the ABC transporter superfamily
A8C77_RS04920	COG2271	Major facilitator Superfamily
A8C77_RS04925	COG1846	Transcriptional regulator
A8C77_RS04930	COG0477	Major facilitator Superfamily
A8C77_RS04935	COG0477	Major facilitator Superfamily
A8C77_RS04940	COG1609	Transcriptional regulator
A8C77_RS04945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8C77_RS04960	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8C77_RS04965	COG1879	ABC-type sugar transport system periplasmic component
A8C77_RS04990	COG1063	alcohol dehydrogenase
A8C77_RS05005	COG3568	Endonuclease Exonuclease Phosphatase
A8C77_RS05030	COG1968	undecaprenyl-diphosphatase activity
A8C77_RS05035	COG0840	transmembrane signaling receptor activity
A8C77_RS05040	COG3584	3D domain protein
A8C77_RS05040	COG1388	LysM domain
A8C77_RS05045	COG1476	TRANSCRIPTIONal
A8C77_RS05060	COG3104	oligopeptide transport
A8C77_RS05065	COG1114	Component of the transport system for branched-chain amino acids
A8C77_RS05080	COG1113	amino acid transport
A8C77_RS05085	COG2252	PERMEase
A8C77_RS05110	COG0475	glutathione-regulated potassium exporter activity
A8C77_RS05110	COG0569	domain protein
A8C77_RS05125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8C77_RS05130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8C77_RS05135	COG0833	amino acid
A8C77_RS05140	COG4990	cell redox homeostasis
A8C77_RS05155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8C77_RS05160	COG0697	spore germination
A8C77_RS05165	COG0531	amino acid
A8C77_RS05180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A8C77_RS05185	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A8C77_RS05190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A8C77_RS05190	COG1918	ferrous iron import across plasma membrane
A8C77_RS05195	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A8C77_RS05200	COG0573	inorganic phosphate transmembrane transporter activity
A8C77_RS05205	COG0581	inorganic phosphate transmembrane transporter activity
A8C77_RS05215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8C77_RS05330	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A8C77_RS05355	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A8C77_RS05360	COG1116	anion transmembrane transporter activity
A8C77_RS05365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8C77_RS05370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8C77_RS05375	COG0352	thiamine-phosphate diphosphorylase activity
A8C77_RS05380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C77_RS05385	COG2104	thiamine diphosphate biosynthetic process
A8C77_RS05395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8C77_RS05400	COG0351	phosphomethylpyrimidine kinase
A8C77_RS05440	COG2205	protein histidine kinase activity
A8C77_RS05445	COG2814	Major facilitator Superfamily
A8C77_RS05450	COG1846	Transcriptional regulator
A8C77_RS05465	COG2252	PERMEase
A8C77_RS05470	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS05485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8C77_RS05490	COG1621	beta-fructofuranosidase activity
A8C77_RS05495	COG1263	PTS System
A8C77_RS05495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8C77_RS05500	COG1609	Transcriptional regulator
A8C77_RS05510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C77_RS05515	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A8C77_RS05555	COG0778	Nitroreductase
A8C77_RS05560	COG2719	SpoVR family
A8C77_RS05585	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8C77_RS05590	COG1937	Protein conserved in bacteria
A8C77_RS05595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8C77_RS05595	COG0425	Belongs to the sulfur carrier protein TusA family
A8C77_RS05600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8C77_RS05600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C77_RS05605	COG0425	Belongs to the sulfur carrier protein TusA family
A8C77_RS05610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8C77_RS05620	COG2210	Belongs to the sulfur carrier protein TusA family
A8C77_RS05625	COG0730	response to heat
A8C77_RS05635	COG1316	TRANSCRIPTIONal
A8C77_RS05640	COG0604	alcohol dehydrogenase
A8C77_RS05645	COG1283	sodium-dependent phosphate transmembrane transporter activity
A8C77_RS05660	COG3711	transcriptional antiterminator
A8C77_RS05660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8C77_RS05665	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8C77_RS05670	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8C77_RS05690	COG3584	3D domain protein
A8C77_RS05690	COG1388	LysM domain
A8C77_RS05695	COG0577	efflux transmembrane transporter activity
A8C77_RS05700	COG1136	(ABC) transporter
A8C77_RS05710	COG5522	Integral membrane protein (intg_mem_TP0381)
A8C77_RS05725	COG1114	Component of the transport system for branched-chain amino acids
A8C77_RS05730	COG3546	catalase activity
A8C77_RS05765	COG0586	Pfam SNARE associated Golgi protein
A8C77_RS05800	COG0531	amino acid
A8C77_RS05805	COG0475	glutathione-regulated potassium exporter activity
A8C77_RS05815	COG1737	Transcriptional regulator
A8C77_RS05825	COG1263	PTS System
A8C77_RS05825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8C77_RS05835	COG2259	Doxx family
A8C77_RS05850	COG0697	spore germination
A8C77_RS05855	COG1522	sequence-specific DNA binding
A8C77_RS05870	COG2076	Multidrug Resistance protein
A8C77_RS05875	COG1309	transcriptional regulator
A8C77_RS05880	COG2814	Major facilitator Superfamily
A8C77_RS05885	COG1733	regulation of RNA biosynthetic process
A8C77_RS05895	COG2249	NAD(P)H dehydrogenase (quinone) activity
A8C77_RS05900	COG4533	DNA binding
A8C77_RS05905	COG2211	Major facilitator Superfamily
A8C77_RS05915	COG0693	protein deglycase activity
A8C77_RS05920	COG0753	catalase activity
A8C77_RS05930	COG0531	amino acid
A8C77_RS05935	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A8C77_RS05945	COG1012	belongs to the aldehyde dehydrogenase family
A8C77_RS05955	COG1132	(ABC) transporter
A8C77_RS05965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8C77_RS05970	COG0765	amino acid transport
A8C77_RS05975	COG1126	abc transporter atp-binding protein
A8C77_RS05990	COG0189	ligase activity
A8C77_RS06020	COG0028	Belongs to the TPP enzyme family
A8C77_RS06025	COG3527	Alpha-acetolactate decarboxylase
A8C77_RS06040	COG0561	phosphatase activity
A8C77_RS06055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8C77_RS06070	COG0659	secondary active sulfate transmembrane transporter activity
A8C77_RS06090	COG0653	protein targeting
A8C77_RS06095	COG2244	polysaccharide biosynthetic process
A8C77_RS06105	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8C77_RS06110	COG4196	transglutaminase domain protein
A8C77_RS06125	COG1696	Membrane protein involved in D-alanine export
A8C77_RS06140	COG1024	Enoyl-CoA hydratase
A8C77_RS06160	COG1363	Peptidase, m42
A8C77_RS06180	COG3938	Belongs to the proline racemase family
A8C77_RS06220	COG0601	transmembrane transport
A8C77_RS06225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C77_RS06235	COG4608	Belongs to the ABC transporter superfamily
A8C77_RS06265	COG0477	Major facilitator Superfamily
A8C77_RS06270	COG3290	protein histidine kinase activity
A8C77_RS06275	COG4565	transcriptional regulatory protein
A8C77_RS06280	COG3181	Tripartite tricarboxylate transporter family receptor
A8C77_RS06310	COG0789	Transcriptional regulator
A8C77_RS06310	COG4978	Transcriptional regulator
A8C77_RS06325	COG0305	Participates in initiation and elongation during chromosome replication
A8C77_RS06365	COG0477	Major facilitator Superfamily
A8C77_RS06415	COG3320	Male sterility
A8C77_RS06415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8C77_RS06420	COG1309	transcriptional regulator
A8C77_RS06440	COG1183	phosphatidylcholine synthase activity
A8C77_RS06460	COG2376	Dihydroxyacetone kinase
A8C77_RS06470	COG2376	Dihydroxyacetone kinase
A8C77_RS06475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8C77_RS06480	COG1959	2 iron, 2 sulfur cluster binding
A8C77_RS06505	COG3437	response regulator, receiver
A8C77_RS06505	COG2770	Histidine kinase
A8C77_RS06555	COG3237	CsbD-like
A8C77_RS06580	COG1191	sigma factor activity
A8C77_RS06590	COG2208	phosphoserine phosphatase activity
A8C77_RS06595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A8C77_RS06600	COG0784	Response regulator, receiver
A8C77_RS06600	COG2198	Histidine kinase
A8C77_RS06600	COG2205	protein histidine kinase activity
A8C77_RS06600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8C77_RS06660	COG0420	3'-5' exonuclease activity
A8C77_RS06665	COG4717	serine-type aminopeptidase activity
A8C77_RS06685	COG1309	transcriptional regulator
A8C77_RS06690	COG2814	Major facilitator Superfamily
A8C77_RS06695	COG0346	lactoylglutathione lyase activity
A8C77_RS06700	COG0346	lactoylglutathione lyase activity
A8C77_RS06705	COG0457	Tetratricopeptide repeat
A8C77_RS06710	COG2267	carboxylic ester hydrolase activity
A8C77_RS06730	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A8C77_RS06735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8C77_RS06745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8C77_RS06785	COG0477	Major facilitator Superfamily
A8C77_RS06790	COG0477	Major facilitator Superfamily
A8C77_RS06800	COG3973	AAA domain
A8C77_RS06805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8C77_RS06830	COG4980	gas vesicle protein
A8C77_RS06835	COG0537	adenosine 5'-monophosphoramidase activity
A8C77_RS06840	COG1131	(ABC) transporter
A8C77_RS06845	COG4473	ABC transporter
A8C77_RS06855	COG1309	transcriptional regulator
A8C77_RS06865	COG3402	PFAM membrane-flanked domain
A8C77_RS06875	COG3428	Bacterial PH domain
A8C77_RS06915	COG3402	PFAM membrane-flanked domain
A8C77_RS06920	COG3428	Bacterial PH domain
A8C77_RS06925	COG2329	Antibiotic biosynthesis monooxygenase
A8C77_RS06930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8C77_RS06935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A8C77_RS06940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8C77_RS06945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A8C77_RS06980	COG1309	transcriptional regulator
A8C77_RS06985	COG1511	domain protein
A8C77_RS07010	COG1609	Transcriptional regulator
A8C77_RS07020	COG1234	tRNA 3'-trailer cleavage
A8C77_RS07025	COG0095	Lipoate-protein ligase
A8C77_RS07035	COG0318	PFAM AMP-dependent synthetase and ligase
A8C77_RS07065	COG3209	COG3209 Rhs family protein
A8C77_RS07110	COG1408	metallophosphoesterase
A8C77_RS07115	COG1078	dGTPase activity
A8C77_RS07125	COG1595	DNA-templated transcription, initiation
A8C77_RS07130	COG3708	Transcriptional regulator
A8C77_RS07130	COG2207	Transcriptional regulator
A8C77_RS07145	COG2205	protein histidine kinase activity
A8C77_RS07150	COG0745	RESPONSE REGULATOR receiver
A8C77_RS07175	COG0501	Belongs to the peptidase M48B family
A8C77_RS07180	COG0840	transmembrane signaling receptor activity
A8C77_RS07185	COG0697	spore germination
A8C77_RS07205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A8C77_RS07210	COG2224	Isocitrate lyase
A8C77_RS07235	COG4903	ComK protein
A8C77_RS07240	COG0398	Pfam SNARE associated Golgi protein
A8C77_RS07250	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A8C77_RS07255	COG1074	ATP-dependent DNA helicase activity
A8C77_RS07300	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8C77_RS07325	COG0367	asparagine synthase
A8C77_RS07330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8C77_RS07335	COG0753	catalase activity
A8C77_RS07340	COG0004	ammonium transporteR
A8C77_RS07365	COG2996	Protein conserved in bacteria
A8C77_RS07375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8C77_RS07385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8C77_RS07400	COG0561	phosphatase activity
A8C77_RS07415	COG0542	response to heat
A8C77_RS07425	COG2267	carboxylic ester hydrolase activity
A8C77_RS07440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8C77_RS07445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8C77_RS07450	COG5504	Zn-dependent protease
A8C77_RS07460	COG0180	Tryptophanyl-tRNA synthetase
A8C77_RS07470	COG4166	transmembrane transport
A8C77_RS07475	COG0601	transmembrane transport
A8C77_RS07480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C77_RS07485	COG0444	Belongs to the ABC transporter superfamily
A8C77_RS07490	COG4608	Belongs to the ABC transporter superfamily
A8C77_RS07495	COG0534	Mate efflux family protein
A8C77_RS07500	COG4166	transmembrane transport
A8C77_RS07520	COG0861	Integral membrane protein TerC family
A8C77_RS07525	COG4862	establishment of competence for transformation
A8C77_RS07530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8C77_RS07540	COG1164	Oligoendopeptidase f
A8C77_RS07550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A8C77_RS07555	COG2346	COG2346, Truncated hemoglobins
A8C77_RS07560	COG4116	CYTH
A8C77_RS07570	COG2357	RelA SpoT domain protein
A8C77_RS07580	COG0564	pseudouridine synthase activity
A8C77_RS07595	COG0772	Belongs to the SEDS family
A8C77_RS07600	COG0463	Glycosyl transferase, family 2
A8C77_RS07600	COG1216	Glycosyl transferase, family 2
A8C77_RS07620	COG0457	Tetratricopeptide repeat
A8C77_RS07620	COG0463	Glycosyl transferase, family 2
A8C77_RS07640	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A8C77_RS07655	COG1091	dTDP-4-dehydrorhamnose reductase activity
A8C77_RS07700	COG2153	protein acetylation
A8C77_RS07710	COG2382	esterase
A8C77_RS07725	COG5492	domain, Protein
A8C77_RS07730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8C77_RS07745	COG0512	Glutamine amidotransferase of anthranilate synthase
A8C77_RS07745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8C77_RS07780	COG1620	l-lactate permease
A8C77_RS07785	COG5634	Uncharacterized conserved protein (DUF2278)
A8C77_RS07835	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8C77_RS07845	COG1476	TRANSCRIPTIONal
A8C77_RS07905	COG2226	methyltransferase
A8C77_RS07915	COG1686	Belongs to the peptidase S11 family
A8C77_RS07920	COG0681	Belongs to the peptidase S26 family
A8C77_RS07955	COG1012	belongs to the aldehyde dehydrogenase family
A8C77_RS07960	COG3842	ATPase activity
A8C77_RS07965	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8C77_RS07970	COG1177	transmembrane transport
A8C77_RS07975	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A8C77_RS07985	COG2409	Drug exporters of the RND superfamily
A8C77_RS07995	COG0564	pseudouridine synthase activity
A8C77_RS08005	COG2340	Cysteine-rich secretory protein family
A8C77_RS08010	COG0247	lactate metabolic process
A8C77_RS08015	COG0277	FAD linked oxidase domain protein
A8C77_RS08020	COG3835	regulator
A8C77_RS08030	COG0745	RESPONSE REGULATOR receiver
A8C77_RS08035	COG5002	protein histidine kinase activity
A8C77_RS08040	COG2186	Transcriptional regulator
A8C77_RS08060	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A8C77_RS08070	COG2116	formate transmembrane transporter activity
A8C77_RS08075	COG0861	Integral membrane protein TerC family
A8C77_RS08080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A8C77_RS08090	COG2030	dehydratase
A8C77_RS08110	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS08115	COG3243	poly(R)-hydroxyalkanoic acid synthase
A8C77_RS08120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C77_RS08125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A8C77_RS08140	COG1840	ABC-type Fe3 transport system, periplasmic component
A8C77_RS08170	COG1349	DNA-binding transcription factor activity
A8C77_RS08195	COG2861	carbohydrate metabolic process
A8C77_RS08205	COG3852	Histidine kinase
A8C77_RS08210	COG1846	Transcriptional regulator
A8C77_RS08220	COG2318	DinB family
A8C77_RS08230	COG5002	protein histidine kinase activity
A8C77_RS08240	COG0720	synthase
A8C77_RS08255	COG4873	Protein conserved in bacteria
A8C77_RS08290	COG1780	Probably involved in ribonucleotide reductase function
A8C77_RS08305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8C77_RS08310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8C77_RS08315	COG1725	Transcriptional regulator
A8C77_RS08320	COG1131	(ABC) transporter
A8C77_RS08330	COG1131	(ABC) transporter
A8C77_RS08335	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A8C77_RS08350	COG1522	sequence-specific DNA binding
A8C77_RS08360	COG1335	isochorismatase
A8C77_RS08370	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8C77_RS08375	COG2070	2-Nitropropane dioxygenase
A8C77_RS08380	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A8C77_RS08390	COG1696	Membrane protein involved in D-alanine export
A8C77_RS08415	COG0716	FMN binding
A8C77_RS08430	COG3173	Aminoglycoside phosphotransferase
A8C77_RS08450	COG0534	Mate efflux family protein
A8C77_RS08455	COG1968	undecaprenyl-diphosphatase activity
A8C77_RS08470	COG1846	Transcriptional regulator
A8C77_RS08480	COG1301	dicarboxylic acid transport
A8C77_RS08485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A8C77_RS08490	COG4709	membrane
A8C77_RS08495	COG3874	Sporulation protein YtfJ
A8C77_RS08525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8C77_RS08530	COG0028	Belongs to the TPP enzyme family
A8C77_RS08535	COG0440	acetolactate synthase activity
A8C77_RS08540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A8C77_RS08550	COG0473	3-isopropylmalate dehydrogenase activity
A8C77_RS08575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8C77_RS08610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A8C77_RS08625	COG1183	phosphatidylcholine synthase activity
A8C77_RS08630	COG1368	sulfuric ester hydrolase activity
A8C77_RS08640	COG0019	diaminopimelate decarboxylase activity
A8C77_RS08660	COG0529	Catalyzes the synthesis of activated sulfate
A8C77_RS08665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8C77_RS08685	COG1648	precorrin-2 dehydrogenase activity
A8C77_RS08695	COG0733	neurotransmitter:sodium symporter activity
A8C77_RS08715	COG1757	Na H antiporter
A8C77_RS08730	COG4758	membrane
A8C77_RS08735	COG4585	Histidine kinase
A8C77_RS08740	COG2197	response regulator
A8C77_RS08750	COG1114	Component of the transport system for branched-chain amino acids
A8C77_RS08760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8C77_RS08785	COG1017	nitric oxide dioxygenase activity
A8C77_RS08785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8C77_RS08805	COG0730	response to heat
A8C77_RS08810	COG0306	phosphate transporter
A8C77_RS08815	COG1392	Phosphate transport regulator
A8C77_RS08820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8C77_RS08835	COG3852	Histidine kinase
A8C77_RS08840	COG1801	Protein of unknown function DUF72
A8C77_RS08850	COG0582	viral genome integration into host DNA
A8C77_RS08855	COG5002	protein histidine kinase activity
A8C77_RS08875	COG0392	lysyltransferase activity
A8C77_RS08875	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A8C77_RS08890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8C77_RS08895	COG1686	Belongs to the peptidase S11 family
A8C77_RS08900	COG2715	membrane protein required for spore maturation
A8C77_RS08905	COG0700	Nucleoside recognition
A8C77_RS08910	COG1187	pseudouridine synthase activity
A8C77_RS08920	COG1333	cytochrome c biogenesis protein
A8C77_RS08925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8C77_RS08930	COG0745	RESPONSE REGULATOR receiver
A8C77_RS08935	COG5002	protein histidine kinase activity
A8C77_RS08940	COG2096	Adenosyltransferase
A8C77_RS08955	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A8C77_RS08960	COG1141	Ferredoxin
A8C77_RS08965	COG4955	Helix-turn-helix domain
A8C77_RS08970	COG0514	ATP-dependent DNA helicase (RecQ)
A8C77_RS08975	COG1266	CAAX protease self-immunity
A8C77_RS08995	COG4862	establishment of competence for transformation
A8C77_RS09000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8C77_RS09020	COG0492	ferredoxin-NADP+ reductase activity
A8C77_RS09025	COG0252	asparaginase activity
A8C77_RS09095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A8C77_RS09110	COG0142	geranyltranstransferase activity
A8C77_RS09120	COG0142	geranyltranstransferase activity
A8C77_RS09140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8C77_RS09145	COG0457	Tetratricopeptide repeat
A8C77_RS09165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8C77_RS09175	COG4347	Protein of unknown function (DUF1405)
A8C77_RS09190	COG2738	Putative neutral zinc metallopeptidase
A8C77_RS09200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8C77_RS09210	COG1694	Mazg nucleotide pyrophosphohydrolase
A8C77_RS09225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8C77_RS09230	COG0438	transferase activity, transferring glycosyl groups
A8C77_RS09270	COG1199	ATP-dependent helicase activity
A8C77_RS09270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8C77_RS09290	COG3935	DnaD domain protein
A8C77_RS09295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A8C77_RS09305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8C77_RS09305	COG4499	WXG100 protein secretion system (Wss), protein YukC
A8C77_RS09360	COG0116	Belongs to the methyltransferase superfamily
A8C77_RS09370	COG1199	ATP-dependent helicase activity
A8C77_RS09375	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A8C77_RS09385	COG3173	Aminoglycoside phosphotransferase
A8C77_RS09390	COG0024	Methionine aminopeptidase
A8C77_RS09400	COG2233	PERMEase
A8C77_RS09405	COG2311	Membrane
A8C77_RS09410	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A8C77_RS09420	COG0456	acetyltransferase
A8C77_RS09455	COG0754	glutathionylspermidine amidase activity
A8C77_RS09470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8C77_RS09495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8C77_RS09510	COG1215	transferase activity, transferring glycosyl groups
A8C77_RS09530	COG0454	-acetyltransferase
A8C77_RS09550	COG0328	RNA-DNA hybrid ribonuclease activity
A8C77_RS09590	COG1280	lysine exporter protein (LysE YggA)
A8C77_RS09605	COG3162	membrane
A8C77_RS09610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8C77_RS09615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8C77_RS09625	COG0475	glutathione-regulated potassium exporter activity
A8C77_RS09635	COG0789	Transcriptional regulator
A8C77_RS09635	COG4978	Transcriptional regulator
A8C77_RS09645	COG2323	membrane
A8C77_RS09650	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A8C77_RS09705	COG1923	regulation of RNA biosynthetic process
A8C77_RS09715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A8C77_RS09720	COG1360	Flagellar Motor Protein
A8C77_RS09725	COG2201	protein-glutamate methylesterase activity
A8C77_RS09735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8C77_RS09735	COG1776	CheC inhibitor of MCP methylation
A8C77_RS09750	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A8C77_RS09770	COG1256	bacterial-type flagellum assembly
A8C77_RS09775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8C77_RS09800	COG1815	bacterial-type flagellum-dependent cell motility
A8C77_RS09805	COG1558	bacterial-type flagellum-dependent cell motility
A8C77_RS09815	COG1766	The M ring may be actively involved in energy transduction
A8C77_RS09825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8C77_RS09835	COG1157	protein secretion by the type III secretion system
A8C77_RS09885	COG0463	Glycosyl transferase, family 2
A8C77_RS09915	COG0457	Tetratricopeptide repeat
A8C77_RS09915	COG0463	Glycosyl transferase, family 2
A8C77_RS09940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8C77_RS09945	COG0741	lytic transglycosylase activity
A8C77_RS09960	COG1776	CheC inhibitor of MCP methylation
A8C77_RS09960	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8C77_RS09970	COG1338	Plays a role in the flagellum-specific transport system
A8C77_RS09975	COG1987	bacterial-type flagellum assembly
A8C77_RS09985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8C77_RS09990	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8C77_RS10000	COG4786	Flagellar basal body rod
A8C77_RS10005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8C77_RS10030	COG1309	transcriptional regulator
A8C77_RS10050	COG2329	Antibiotic biosynthesis monooxygenase
A8C77_RS10075	COG0583	DNA-binding transcription factor activity
A8C77_RS10080	COG3842	ATPase activity
A8C77_RS10085	COG0725	ABC transporter, periplasmic molybdate-binding protein
A8C77_RS10095	COG1234	tRNA 3'-trailer cleavage
A8C77_RS10120	COG1686	Belongs to the peptidase S11 family
A8C77_RS10130	COG0406	alpha-ribazole phosphatase activity
A8C77_RS10160	COG0367	asparagine synthase
A8C77_RS10190	COG1802	Transcriptional regulator
A8C77_RS10195	COG0697	spore germination
A8C77_RS10200	COG0523	cobalamin synthesis protein
A8C77_RS10205	COG0701	Predicted permease
A8C77_RS10215	COG0438	transferase activity, transferring glycosyl groups
A8C77_RS10215	COG1216	Glycosyl transferase, family 2
A8C77_RS10220	COG1757	Na H antiporter
A8C77_RS10225	COG0114	fumarate hydratase activity
A8C77_RS10255	COG3340	Belongs to the peptidase S51 family
A8C77_RS10275	COG0785	Cytochrome C biogenesis protein
A8C77_RS10310	COG2733	membrane
A8C77_RS10345	COG1131	(ABC) transporter
A8C77_RS10360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8C77_RS10365	COG0528	UMP kinase activity
A8C77_RS10375	COG1027	Aspartate ammonia-lyase
A8C77_RS10380	COG0281	malic enzyme
A8C77_RS10385	COG4191	Histidine kinase
A8C77_RS10390	COG0784	Response regulator, receiver
A8C77_RS10395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8C77_RS10455	COG1051	belongs to the nudix hydrolase family
A8C77_RS10460	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8C77_RS10470	COG2814	Major facilitator Superfamily
A8C77_RS10485	COG1966	Carbon starvation protein
A8C77_RS10500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8C77_RS10510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8C77_RS10520	COG2223	nitrite transmembrane transporter activity
A8C77_RS10525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8C77_RS10540	COG2244	polysaccharide biosynthetic process
A8C77_RS10545	COG0733	neurotransmitter:sodium symporter activity
A8C77_RS10555	COG5566	PFAM Mor transcription activator
A8C77_RS10560	COG2323	membrane
A8C77_RS10575	COG2084	Dehydrogenase
A8C77_RS10590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8C77_RS10600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8C77_RS10605	COG0028	Belongs to the TPP enzyme family
A8C77_RS10610	COG0440	acetolactate synthase activity
A8C77_RS10615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A8C77_RS10625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8C77_RS10650	COG2814	Major facilitator Superfamily
A8C77_RS10655	COG3384	dioxygenase
A8C77_RS10665	COG3279	Response regulator of the LytR AlgR family
A8C77_RS10670	COG0427	acetyl-CoA hydrolase
A8C77_RS10690	COG1073	alpha beta
A8C77_RS10695	COG4166	transmembrane transport
A8C77_RS10720	COG0535	radical SAM domain protein
A8C77_RS10725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8C77_RS10745	COG1914	H( )-stimulated, divalent metal cation uptake system
A8C77_RS10760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8C77_RS10795	COG2390	Transcriptional regulator
A8C77_RS10805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8C77_RS10810	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A8C77_RS10825	COG4224	UPF0291 protein
A8C77_RS10845	COG0006	proline dipeptidase activity
A8C77_RS10850	COG2132	Multicopper oxidase
A8C77_RS10865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8C77_RS10880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8C77_RS10895	COG1276	copper resistance
A8C77_RS10895	COG2372	response to copper ion
A8C77_RS10900	COG4549	nuclear export factor GLE1
A8C77_RS10910	COG0697	spore germination
A8C77_RS10915	COG0583	DNA-binding transcription factor activity
A8C77_RS10920	COG1959	2 iron, 2 sulfur cluster binding
A8C77_RS10925	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A8C77_RS10930	COG0778	Nitroreductase
A8C77_RS10945	COG0628	permease
A8C77_RS10955	COG1231	oxidoreductase activity
A8C77_RS10960	COG0523	cobalamin synthesis protein
A8C77_RS10975	COG0318	PFAM AMP-dependent synthetase and ligase
A8C77_RS10980	COG2030	dehydratase
A8C77_RS10985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8C77_RS10995	COG0411	ABC transporter
A8C77_RS11015	COG0583	DNA-binding transcription factor activity
A8C77_RS11035	COG1846	Transcriptional regulator
A8C77_RS11045	COG1271	oxidase subunit
A8C77_RS11050	COG1294	oxidase, subunit
A8C77_RS11055	COG4988	ABC transporter
A8C77_RS11060	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A8C77_RS11080	COG1686	Belongs to the peptidase S11 family
A8C77_RS11095	COG0791	NLP P60 protein
A8C77_RS11095	COG1388	LysM domain
A8C77_RS11105	COG1132	(ABC) transporter
A8C77_RS11110	COG1132	(ABC) transporter
A8C77_RS11115	COG0745	RESPONSE REGULATOR receiver
A8C77_RS11120	COG5002	protein histidine kinase activity
A8C77_RS11130	COG0300	oxidoreductase activity
A8C77_RS11165	COG0460	homoserine dehydrogenase
A8C77_RS11190	COG1316	TRANSCRIPTIONal
A8C77_RS11200	COG0745	RESPONSE REGULATOR receiver
A8C77_RS11205	COG5002	protein histidine kinase activity
A8C77_RS11220	COG1285	pathogenesis
A8C77_RS11225	COG1247	-acetyltransferase
A8C77_RS11245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8C77_RS11255	COG1082	Xylose isomerase domain protein TIM barrel
A8C77_RS11270	COG1279	arginine transmembrane transporter activity
A8C77_RS11280	COG1752	Esterase of the alpha-beta hydrolase superfamily
A8C77_RS11320	COG2002	toxin-antitoxin pair type II binding
A8C77_RS11325	COG1404	Belongs to the peptidase S8 family
A8C77_RS11330	COG0640	Transcriptional regulator
A8C77_RS11335	COG0667	Aldo Keto reductase
A8C77_RS11340	COG2814	Major facilitator Superfamily
A8C77_RS11365	COG0840	transmembrane signaling receptor activity
A8C77_RS11385	COG3949	Membrane
A8C77_RS11390	COG0783	Belongs to the Dps family
A8C77_RS11405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8C77_RS11415	COG1231	oxidoreductase activity
A8C77_RS11425	COG4989	oxidoreductase activity
A8C77_RS11430	COG0523	cobalamin synthesis protein
A8C77_RS11435	COG0456	acetyltransferase
A8C77_RS11495	COG3443	Belongs to the bacterial solute-binding protein 9 family
A8C77_RS11495	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8C77_RS11505	COG0702	epimerase
A8C77_RS11515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8C77_RS11525	COG4166	transmembrane transport
A8C77_RS11540	COG0406	alpha-ribazole phosphatase activity
A8C77_RS11550	COG5337	Spore coat protein CotH
A8C77_RS11555	COG1051	belongs to the nudix hydrolase family
A8C77_RS11560	COG0586	Pfam SNARE associated Golgi protein
A8C77_RS11565	COG2244	polysaccharide biosynthetic process
A8C77_RS11575	COG0701	Predicted permease
A8C77_RS11580	COG3689	TIGRFAM TIGR03943 family protein
A8C77_RS11585	COG1607	acyl-coa hydrolase
A8C77_RS11590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8C77_RS11605	COG0702	epimerase
A8C77_RS11610	COG2839	Protein conserved in bacteria
A8C77_RS11615	COG1253	flavin adenine dinucleotide binding
A8C77_RS11630	COG1114	Component of the transport system for branched-chain amino acids
A8C77_RS11635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8C77_RS11655	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8C77_RS11665	COG1876	peptidase activity
A8C77_RS11675	COG0154	amidase activity
A8C77_RS11680	COG2211	Major facilitator Superfamily
A8C77_RS11700	COG0561	phosphatase activity
A8C77_RS11710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8C77_RS11715	COG4106	trans-aconitate 2-methyltransferase activity
A8C77_RS11730	COG1819	glycosyl
A8C77_RS11735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8C77_RS11740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C77_RS11765	COG0456	acetyltransferase
A8C77_RS11815	COG3874	Sporulation protein YtfJ
A8C77_RS11840	COG2226	methyltransferase
A8C77_RS11860	COG1082	Xylose isomerase domain protein TIM barrel
A8C77_RS11865	COG0346	lactoylglutathione lyase activity
A8C77_RS11875	COG0604	alcohol dehydrogenase
A8C77_RS11880	COG1595	DNA-templated transcription, initiation
A8C77_RS11905	COG0386	Belongs to the glutathione peroxidase family
A8C77_RS11910	COG1305	Transglutaminase-like
A8C77_RS11915	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
A8C77_RS11920	COG0714	Associated with various cellular activities
A8C77_RS11935	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A8C77_RS11940	COG1140	nitrate reductase beta subunit
A8C77_RS11945	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A8C77_RS11950	COG2181	nitrate reductase activity
A8C77_RS11970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8C77_RS11975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A8C77_RS11980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8C77_RS11985	COG0303	'Molybdopterin
A8C77_RS11990	COG0314	molybdopterin synthase activity
A8C77_RS12000	COG2223	nitrite transmembrane transporter activity
A8C77_RS12015	COG1648	precorrin-2 dehydrogenase activity
A8C77_RS12025	COG1587	Uroporphyrinogen-III synthase
A8C77_RS12025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8C77_RS12030	COG2146	nitrite reductase [NAD(P)H] activity
A8C77_RS12035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8C77_RS12040	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A8C77_RS12075	COG2359	stage V sporulation protein S
A8C77_RS12090	COG5632	N-Acetylmuramoyl-L-alanine amidase
A8C77_RS12105	COG1418	mRNA catabolic process
A8C77_RS12110	COG0488	(ABC) transporter
A8C77_RS12125	COG0629	single-stranded DNA binding
A8C77_RS12140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8C77_RS12145	COG1413	lyase activity
A8C77_RS12160	COG2136	Putative SAM-dependent methyltransferase
A8C77_RS12160	COG2521	methyltransferase
A8C77_RS12165	COG0018	arginyl-trna synthetase
A8C77_RS12190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A8C77_RS12205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A8C77_RS12210	COG0017	Asparaginyl-tRNA synthetase
A8C77_RS12230	COG1674	ftsk spoiiie
A8C77_RS12330	COG1929	Belongs to the glycerate kinase type-1 family
A8C77_RS12335	COG0471	metal ion transport
A8C77_RS12340	COG0745	RESPONSE REGULATOR receiver
A8C77_RS12345	COG3850	Histidine kinase
A8C77_RS12345	COG5002	protein histidine kinase activity
A8C77_RS12360	COG0733	neurotransmitter:sodium symporter activity
A8C77_RS12385	COG2610	gluconate transmembrane transporter activity
A8C77_RS12390	COG1454	alcohol dehydrogenase
A8C77_RS12395	COG1794	racemase activity, acting on amino acids and derivatives
A8C77_RS12405	COG0456	acetyltransferase
A8C77_RS12420	COG1131	(ABC) transporter
A8C77_RS12425	COG4473	ABC transporter
A8C77_RS12435	COG0546	phosphoglycolate phosphatase activity
A8C77_RS12455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8C77_RS12470	COG0768	penicillin binding
A8C77_RS12475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8C77_RS12480	COG0204	Acyl-transferase
A8C77_RS12485	COG1272	protein, Hemolysin III
A8C77_RS12495	COG0805	protein transport
A8C77_RS12505	COG1307	EDD domain protein, DegV family
A8C77_RS12510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A8C77_RS12515	COG1999	signal sequence binding
A8C77_RS12520	COG0071	Belongs to the small heat shock protein (HSP20) family
A8C77_RS12525	COG0367	asparagine synthase
A8C77_RS12545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8C77_RS12550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8C77_RS12585	COG0668	transmembrane transport
A8C77_RS12590	COG4585	Histidine kinase
A8C77_RS12590	COG2203	Gaf domain
A8C77_RS12595	COG2197	response regulator
A8C77_RS12605	COG1737	Transcriptional regulator
A8C77_RS12610	COG1064	alcohol dehydrogenase
A8C77_RS12640	COG1070	Carbohydrate kinase
A8C77_RS12645	COG1070	Carbohydrate kinase
A8C77_RS12675	COG1125	glycine betaine transport
A8C77_RS12675	COG0517	IMP dehydrogenase activity
A8C77_RS12680	COG1174	glycine betaine transport
A8C77_RS12715	COG1253	flavin adenine dinucleotide binding
A8C77_RS12720	COG1012	belongs to the aldehyde dehydrogenase family
A8C77_RS12725	COG5506	Protein of unknown function (DUF1694)
A8C77_RS12740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8C77_RS12745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A8C77_RS12750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8C77_RS12755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8C77_RS12760	COG0456	acetyltransferase
A8C77_RS12765	COG3829	transcription factor binding
A8C77_RS12770	COG1509	lysine 2,3-aminomutase activity
A8C77_RS12810	COG4326	sporulation control protein
A8C77_RS12815	COG0671	phosphoesterase, PA-phosphatase related
A8C77_RS12820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8C77_RS12825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C77_RS12855	COG1787	Restriction endonuclease
A8C77_RS12855	COG1715	Restriction endonuclease
A8C77_RS12940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8C77_RS12980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8C77_RS12980	COG4499	WXG100 protein secretion system (Wss), protein YukC
A8C77_RS12990	COG2814	Major facilitator Superfamily
A8C77_RS12995	COG4841	protein insertion into membrane
A8C77_RS13000	COG0372	Belongs to the citrate synthase family
A8C77_RS13005	COG2079	MmgE PrpD family protein
A8C77_RS13010	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A8C77_RS13015	COG1960	acyl-CoA dehydrogenase activity
A8C77_RS13020	COG2084	Dehydrogenase
A8C77_RS13030	COG1280	lysine exporter protein (LysE YggA)
A8C77_RS13035	COG1024	Enoyl-CoA hydratase
A8C77_RS13050	COG0420	3'-5' exonuclease activity
A8C77_RS13055	COG0419	ATPase involved in DNA repair
A8C77_RS13085	COG2223	nitrite transmembrane transporter activity
A8C77_RS13090	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS13095	COG1169	isochorismate synthase
A8C77_RS13100	COG1021	2,3-dihydroxybenzoate-AMP ligase
A8C77_RS13105	COG3433	isochorismatase activity
A8C77_RS13105	COG1535	isochorismatase
A8C77_RS13110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8C77_RS13115	COG3251	PFAM MbtH domain protein
A8C77_RS13120	COG2814	Major facilitator Superfamily
A8C77_RS13135	COG0776	regulation of translation
A8C77_RS13145	COG2318	DinB family
A8C77_RS13155	COG1115	amino acid carrier protein
A8C77_RS13170	COG2329	Antibiotic biosynthesis monooxygenase
A8C77_RS13175	COG1187	pseudouridine synthase activity
A8C77_RS13180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8C77_RS13195	COG0596	Alpha beta hydrolase
A8C77_RS13200	COG2814	Major facilitator Superfamily
A8C77_RS13220	COG2226	methyltransferase
A8C77_RS13265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C77_RS13300	COG1247	-acetyltransferase
A8C77_RS13330	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A8C77_RS13340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8C77_RS13350	COG1278	Cold shock
A8C77_RS13365	COG0010	Belongs to the arginase family
A8C77_RS13370	COG0561	phosphatase activity
A8C77_RS13415	COG0583	DNA-binding transcription factor activity
A8C77_RS13420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8C77_RS13435	COG0583	DNA-binding transcription factor activity
A8C77_RS13440	COG2258	MOSC domain
A8C77_RS13455	COG1132	(ABC) transporter
A8C77_RS13460	COG1132	(ABC) transporter
A8C77_RS13480	COG1396	sequence-specific DNA binding
A8C77_RS13505	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A8C77_RS13510	COG1595	DNA-templated transcription, initiation
A8C77_RS13560	COG2971	BadF BadG BcrA BcrD
A8C77_RS13565	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A8C77_RS13570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A8C77_RS13590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C77_RS13620	COG1309	transcriptional regulator
A8C77_RS13635	COG0577	efflux transmembrane transporter activity
A8C77_RS13635	COG1136	(ABC) transporter
A8C77_RS13640	COG3615	Tellurite resistance protein tehB
A8C77_RS13640	COG0500	methyltransferase
A8C77_RS13650	COG2226	methyltransferase
A8C77_RS13655	COG3961	Belongs to the TPP enzyme family
A8C77_RS13660	COG1846	Transcriptional regulator
A8C77_RS13700	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8C77_RS13715	COG1595	DNA-templated transcription, initiation
A8C77_RS13725	COG0768	penicillin binding
A8C77_RS13735	COG2367	Beta-lactamase
A8C77_RS13740	COG0671	phosphoesterase, PA-phosphatase related
A8C77_RS13745	COG1609	Transcriptional regulator
A8C77_RS13750	COG2814	Major facilitator Superfamily
A8C77_RS13755	COG0673	inositol 2-dehydrogenase activity
A8C77_RS13765	COG1012	belongs to the aldehyde dehydrogenase family
A8C77_RS13780	COG0191	fructose-bisphosphate aldolase activity
A8C77_RS13785	COG3718	enzyme involved in inositol metabolism
A8C77_RS13810	COG0457	Tetratricopeptide repeat
A8C77_RS13815	COG1476	TRANSCRIPTIONal
A8C77_RS13830	COG1876	peptidase activity
A8C77_RS13850	COG1309	transcriptional regulator
A8C77_RS13855	COG0488	(ABC) transporter
A8C77_RS13870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8C77_RS13880	COG1252	NADH dehydrogenase
A8C77_RS13885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8C77_RS13900	COG1131	(ABC) transporter
A8C77_RS13910	COG1309	transcriptional regulator
A8C77_RS13925	COG1960	acyl-CoA dehydrogenase activity
A8C77_RS13930	COG0439	Biotin carboxylase
A8C77_RS13935	COG0511	ligase activity, forming carbon-carbon bonds
A8C77_RS13940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8C77_RS13945	COG1024	Enoyl-CoA hydratase
A8C77_RS13950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8C77_RS13955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8C77_RS13965	COG1247	-acetyltransferase
A8C77_RS13970	COG0572	uridine kinase
A8C77_RS13980	COG2318	DinB family
A8C77_RS13985	COG1686	Belongs to the peptidase S11 family
A8C77_RS14010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8C77_RS14050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8C77_RS14050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8C77_RS14075	COG2814	Major facilitator Superfamily
A8C77_RS14095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8C77_RS14115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C77_RS14130	COG1063	alcohol dehydrogenase
A8C77_RS14145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8C77_RS14150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8C77_RS14165	COG3773	Cell wall hydrolase
A8C77_RS14175	COG0745	RESPONSE REGULATOR receiver
A8C77_RS14205	COG1136	(ABC) transporter
A8C77_RS14230	COG0460	homoserine dehydrogenase
A8C77_RS14235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C77_RS14245	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A8C77_RS14320	COG2124	cytochrome p450
A8C77_RS14355	COG0561	phosphatase activity
A8C77_RS14365	COG5002	protein histidine kinase activity
A8C77_RS14370	COG0768	penicillin binding
A8C77_RS14375	COG1819	glycosyl
A8C77_RS14380	COG1794	racemase activity, acting on amino acids and derivatives
A8C77_RS14390	COG1122	ATPase activity
A8C77_RS14400	COG2205	protein histidine kinase activity
A8C77_RS14410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A8C77_RS14415	COG0604	alcohol dehydrogenase
A8C77_RS14420	COG0768	penicillin binding
A8C77_RS14430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8C77_RS14465	COG0693	protein deglycase activity
A8C77_RS14495	COG2814	Major facilitator Superfamily
A8C77_RS14510	COG0584	glycerophosphoryl diester phosphodiesterase
A8C77_RS14530	COG0697	spore germination
A8C77_RS14555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8C77_RS14565	COG2223	nitrite transmembrane transporter activity
A8C77_RS14580	COG2816	NAD+ diphosphatase activity
A8C77_RS14585	COG0592	DNA-directed DNA polymerase activity
A8C77_RS14590	COG1051	belongs to the nudix hydrolase family
A8C77_RS14625	COG3878	Protein conserved in bacteria
A8C77_RS14655	COG4667	esterase of the alpha-beta hydrolase superfamily
A8C77_RS14680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8C77_RS14695	COG0322	excinuclease ABC activity
A8C77_RS14735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C77_RS14760	COG1011	Hydrolase
A8C77_RS14780	COG0076	glutamate decarboxylase activity
A8C77_RS14795	COG1523	belongs to the glycosyl hydrolase 13 family
A8C77_RS14800	COG3227	Zinc metalloprotease (Elastase)
A8C77_RS14820	COG0201	protein transport
A8C77_RS14830	COG0697	spore germination
A8C77_RS14835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C77_RS14865	COG4129	membrane
A8C77_RS14870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8C77_RS14885	COG2959	enzyme of heme biosynthesis
A8C77_RS14905	COG3483	tryptophan 2,3-dioxygenase activity
A8C77_RS14910	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A8C77_RS14915	COG3844	kynureninase activity
A8C77_RS14920	COG1309	transcriptional regulator
A8C77_RS14950	COG3284	Transcriptional regulator
A8C77_RS14970	COG1349	DNA-binding transcription factor activity
A8C77_RS14990	COG1959	2 iron, 2 sulfur cluster binding
A8C77_RS15005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8C77_RS15010	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8C77_RS15015	COG0022	dehydrogenase e1 component
A8C77_RS15020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8C77_RS15030	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS15035	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A8C77_RS15035	COG0456	acetyltransferase
A8C77_RS15070	COG4176	ABC-type proline glycine betaine transport system permease component
A8C77_RS15075	COG4175	Glycine betaine
A8C77_RS15075	COG0517	IMP dehydrogenase activity
A8C77_RS15100	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A8C77_RS15105	COG2153	protein acetylation
A8C77_RS15110	COG3397	chitin binding
A8C77_RS15125	COG2205	protein histidine kinase activity
A8C77_RS15155	COG2333	competence protein COMEC
A8C77_RS15155	COG0658	competence protein
A8C77_RS15205	COG3973	AAA domain
A8C77_RS15220	COG2105	PFAM AIG2 family protein
A8C77_RS15225	COG0514	ATP-dependent DNA helicase (RecQ)
A8C77_RS15255	COG4637	Psort location Cytoplasmic, score
A8C77_RS15280	COG3397	chitin binding
A8C77_RS15290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8C77_RS15295	COG1115	amino acid carrier protein
A8C77_RS15300	COG1012	belongs to the aldehyde dehydrogenase family
A8C77_RS15305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8C77_RS15315	COG3938	Belongs to the proline racemase family
A8C77_RS15320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C77_RS15360	COG0586	Pfam SNARE associated Golgi protein
A8C77_RS15375	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A8C77_RS15380	COG0519	Catalyzes the synthesis of GMP from XMP
A8C77_RS15385	COG4166	transmembrane transport
A8C77_RS15395	COG4948	Mandelate Racemase Muconate Lactonizing
A8C77_RS15435	COG2936	dipeptidyl-peptidase activity
A8C77_RS15440	COG5002	protein histidine kinase activity
A8C77_RS15445	COG0745	RESPONSE REGULATOR receiver
A8C77_RS15485	COG1307	EDD domain protein, DegV family
A8C77_RS15505	COG2814	Major facilitator Superfamily
A8C77_RS15515	COG1664	Polymer-forming cytoskeletal
A8C77_RS15520	COG0789	Transcriptional regulator
A8C77_RS15525	COG4533	DNA binding
A8C77_RS15530	COG2814	Major facilitator Superfamily
A8C77_RS15530	COG0477	Major facilitator Superfamily
A8C77_RS15550	COG2261	transglycosylase associated protein
A8C77_RS15565	COG2226	methyltransferase
A8C77_RS15600	COG0436	Aminotransferase
A8C77_RS15605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8C77_RS15610	COG5146	pantothenate kinase activity
A8C77_RS15635	COG1131	(ABC) transporter
A8C77_RS15685	COG0628	permease
A8C77_RS15700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8C77_RS15705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8C77_RS15710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8C77_RS15715	COG1116	anion transmembrane transporter activity
A8C77_RS15735	COG2816	NAD+ diphosphatase activity
A8C77_RS15755	COG2746	aminoglycoside 3-N-acetyltransferase activity
A8C77_RS15780	COG0697	spore germination
A8C77_RS15785	COG2318	DinB family
A8C77_RS15805	COG4912	Dna alkylation repair
A8C77_RS15825	COG0861	Integral membrane protein TerC family
A8C77_RS15830	COG1368	sulfuric ester hydrolase activity
A8C77_RS15835	COG0488	(ABC) transporter
A8C77_RS15845	COG2409	Drug exporters of the RND superfamily
A8C77_RS15845	COG1033	growth of symbiont in host cell
A8C77_RS15850	COG2409	Drug exporters of the RND superfamily
A8C77_RS15850	COG1033	growth of symbiont in host cell
A8C77_RS15855	COG2409	Drug exporters of the RND superfamily
A8C77_RS15855	COG1033	growth of symbiont in host cell
A8C77_RS15860	COG1309	transcriptional regulator
A8C77_RS15875	COG0287	Prephenate dehydrogenase
A8C77_RS15880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8C77_RS15885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A8C77_RS15890	COG1605	Chorismate mutase
A8C77_RS15890	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A8C77_RS15935	COG1595	DNA-templated transcription, initiation
A8C77_RS15960	COG1879	ABC-type sugar transport system periplasmic component
A8C77_RS15970	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8C77_RS15980	COG2390	Transcriptional regulator
A8C77_RS16015	COG2329	Antibiotic biosynthesis monooxygenase
A8C77_RS16035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8C77_RS16045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8C77_RS16050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8C77_RS16055	COG4187	Peptidase family M20/M25/M40
A8C77_RS16060	COG1414	Transcriptional regulator
A8C77_RS16065	COG0833	amino acid
A8C77_RS16070	COG1690	Belongs to the RtcB family
A8C77_RS16075	COG3239	Fatty acid desaturase
A8C77_RS16080	COG1785	Belongs to the alkaline phosphatase family
A8C77_RS16090	COG3655	Transcriptional regulator
A8C77_RS16105	COG4377	Putative membrane peptidase family (DUF2324)
A8C77_RS16115	COG3279	Response regulator of the LytR AlgR family
A8C77_RS16125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8C77_RS16130	COG0346	lactoylglutathione lyase activity
A8C77_RS16150	COG0714	Associated with various cellular activities
A8C77_RS16175	COG0463	Glycosyl transferase, family 2
A8C77_RS16200	COG0463	Glycosyl transferase, family 2
A8C77_RS16210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8C77_RS16215	COG0753	catalase activity
A8C77_RS16225	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A8C77_RS16250	COG0714	Associated with various cellular activities
A8C77_RS16260	COG0778	Nitroreductase
A8C77_RS16265	COG1846	Transcriptional regulator
A8C77_RS16300	COG1725	Transcriptional regulator
A8C77_RS16310	COG1136	(ABC) transporter
A8C77_RS16310	COG0577	efflux transmembrane transporter activity
A8C77_RS16335	COG2207	Transcriptional regulator
A8C77_RS16340	COG0456	acetyltransferase
A8C77_RS16360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C77_RS16380	COG0642	Histidine kinase
A8C77_RS16385	COG0745	RESPONSE REGULATOR receiver
A8C77_RS16390	COG0596	Alpha beta hydrolase
A8C77_RS16420	COG0730	response to heat
A8C77_RS16430	COG0833	amino acid
A8C77_RS16440	COG4335	DNA alkylation repair
A8C77_RS16490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A8C77_RS16530	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A8C77_RS16535	COG1414	Transcriptional regulator
A8C77_RS16550	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8C77_RS16555	COG0640	Transcriptional regulator
A8C77_RS16565	COG1960	acyl-CoA dehydrogenase activity
A8C77_RS16585	COG3314	Sporulation integral membrane protein YlbJ
A8C77_RS16600	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A8C77_RS16615	COG0574	Belongs to the PEP-utilizing enzyme family
A8C77_RS16615	COG3848	Pyruvate phosphate dikinase
A8C77_RS16620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C77_RS16635	COG5577	PFAM Coat F domain
A8C77_RS16640	COG3403	YqcI/YcgG family
A8C77_RS16645	COG1280	lysine exporter protein (LysE YggA)
A8C77_RS16680	COG1063	alcohol dehydrogenase
A8C77_RS16695	COG1027	Aspartate ammonia-lyase
A8C77_RS16700	COG0252	asparaginase activity
A8C77_RS16705	COG1396	sequence-specific DNA binding
A8C77_RS16715	COG0322	excinuclease ABC activity
A8C77_RS16720	COG0531	amino acid
A8C77_RS16725	COG1114	Component of the transport system for branched-chain amino acids
A8C77_RS16730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8C77_RS16740	COG0281	malic enzyme
A8C77_RS16765	COG0697	spore germination
A8C77_RS16770	COG0784	Response regulator, receiver
A8C77_RS16780	COG2066	Belongs to the glutaminase family
A8C77_RS16810	COG0737	Belongs to the 5'-nucleotidase family
A8C77_RS16815	COG0753	catalase activity
A8C77_RS16820	COG2267	carboxylic ester hydrolase activity
A8C77_RS16825	COG1335	isochorismatase
A8C77_RS16845	COG0583	DNA-binding transcription factor activity
A8C77_RS16890	COG0415	Belongs to the DNA photolyase family
A8C77_RS16895	COG0288	reversible hydration of carbon dioxide
A8C77_RS16905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8C77_RS16910	COG5609	conserved protein (DUF2294)
A8C77_RS16920	COG1575	Belongs to the MenA family. Type 1 subfamily
A8C77_RS16925	COG2267	carboxylic ester hydrolase activity
A8C77_RS16930	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8C77_RS16935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8C77_RS16940	COG1121	(ABC) transporter
A8C77_RS16970	COG0798	PFAM Bile acid sodium symporter
A8C77_RS16975	COG0346	lactoylglutathione lyase activity
A8C77_RS16980	COG0640	Transcriptional regulator
A8C77_RS16995	COG0443	Heat shock 70 kDa protein
A8C77_RS17010	COG1522	sequence-specific DNA binding
A8C77_RS17025	COG0346	lactoylglutathione lyase activity
A8C77_RS17050	COG2169	Transcriptional regulator
A8C77_RS17095	COG2814	Major facilitator Superfamily
A8C77_RS17120	COG0745	RESPONSE REGULATOR receiver
A8C77_RS17125	COG5002	protein histidine kinase activity
A8C77_RS17125	COG3850	Histidine kinase
A8C77_RS17155	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A8C77_RS17180	COG1476	TRANSCRIPTIONal
A8C77_RS17195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C77_RS17200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8C77_RS17210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8C77_RS17215	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A8C77_RS17230	COG1136	(ABC) transporter
A8C77_RS17235	COG0577	efflux transmembrane transporter activity
A8C77_RS17255	COG3850	Histidine kinase
A8C77_RS17255	COG5002	protein histidine kinase activity
A8C77_RS17265	COG2364	Membrane
A8C77_RS17270	COG1846	Transcriptional regulator
A8C77_RS17280	COG2808	Putative FMN-binding domain
A8C77_RS17285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8C77_RS17290	COG2271	Major facilitator Superfamily
A8C77_RS17295	COG1556	Lactate utilization protein
A8C77_RS17300	COG1139	Iron-sulfur cluster binding protein
A8C77_RS17310	COG0583	DNA-binding transcription factor activity
A8C77_RS17320	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8C77_RS17345	COG0738	Major facilitator superfamily
A8C77_RS17350	COG0673	inositol 2-dehydrogenase activity
A8C77_RS17355	COG0561	phosphatase activity
A8C77_RS17365	COG1609	Transcriptional regulator
A8C77_RS17370	COG0457	Tetratricopeptide repeat
A8C77_RS17390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8C77_RS17420	COG0534	Mate efflux family protein
A8C77_RS17435	COG2814	Major facilitator Superfamily
A8C77_RS17440	COG1309	transcriptional regulator
A8C77_RS17455	COG0814	amino acid
A8C77_RS17460	COG1760	l-serine dehydratase
A8C77_RS17465	COG1760	l-serine dehydratase
A8C77_RS17475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A8C77_RS17480	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A8C77_RS17490	COG1335	isochorismatase
A8C77_RS17495	COG1522	sequence-specific DNA binding
A8C77_RS17500	COG0531	amino acid
A8C77_RS17515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8C77_RS17535	COG1595	DNA-templated transcription, initiation
A8C77_RS17550	COG0662	Cupin 2, conserved barrel domain protein
A8C77_RS17560	COG2207	Transcriptional regulator
A8C77_RS17560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8C77_RS17615	COG0477	Major facilitator Superfamily
A8C77_RS17625	COG1846	Transcriptional regulator
A8C77_RS17630	COG2814	Major facilitator Superfamily
A8C77_RS17640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A8C77_RS17645	COG1131	(ABC) transporter
A8C77_RS17665	COG2076	Multidrug Resistance protein
A8C77_RS17670	COG1309	transcriptional regulator
A8C77_RS17685	COG2031	fatty acid transporter
A8C77_RS17695	COG2249	NAD(P)H dehydrogenase (quinone) activity
A8C77_RS17725	COG1122	ATPase activity
A8C77_RS17730	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8C77_RS17745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A8C77_RS17750	COG1288	antiporter activity
A8C77_RS17755	COG2356	endonuclease I
A8C77_RS17770	COG3620	sequence-specific DNA binding
A8C77_RS17775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A8C77_RS17780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8C77_RS17785	COG0124	histidyl-tRNA synthetase
A8C77_RS17800	COG1733	regulation of RNA biosynthetic process
A8C77_RS17805	COG0778	Nitroreductase
A8C77_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS17835	COG1131	(ABC) transporter
A8C77_RS17860	COG1011	Hydrolase
A8C77_RS17870	COG2365	Tyrosine phosphatase family
A8C77_RS17895	COG0346	lactoylglutathione lyase activity
A8C77_RS17900	COG1940	carbohydrate kinase activity
A8C77_RS17905	COG0738	Major facilitator superfamily
A8C77_RS17910	COG0110	maltose O-acetyltransferase activity
A8C77_RS17925	COG1136	(ABC) transporter
A8C77_RS17925	COG0577	efflux transmembrane transporter activity
A8C77_RS17935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A8C77_RS17940	COG0628	permease
A8C77_RS17960	COG2226	methyltransferase
A8C77_RS17970	COG0477	Major facilitator Superfamily
A8C77_RS18000	COG1253	flavin adenine dinucleotide binding
A8C77_RS18005	COG0789	Transcriptional regulator
A8C77_RS18010	COG0697	spore germination
A8C77_RS18015	COG1357	PFAM Pentapeptide repeats (8 copies)
A8C77_RS18020	COG3813	Protein conserved in bacteria
A8C77_RS18025	COG2706	6-phosphogluconolactonase activity
A8C77_RS18030	COG1070	Carbohydrate kinase
A8C77_RS18040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8C77_RS18045	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A8C77_RS18055	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A8C77_RS18060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A8C77_RS18065	COG0604	alcohol dehydrogenase
A8C77_RS18070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8C77_RS18080	COG3321	synthase
A8C77_RS18080	COG0604	alcohol dehydrogenase
A8C77_RS18090	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS18115	COG0656	L-ascorbic acid biosynthetic process
A8C77_RS18120	COG2814	Major facilitator Superfamily
A8C77_RS18135	COG0346	lactoylglutathione lyase activity
A8C77_RS18140	COG0814	amino acid
A8C77_RS18165	COG1393	Belongs to the ArsC family
A8C77_RS18175	COG1733	regulation of RNA biosynthetic process
A8C77_RS18180	COG2188	Transcriptional regulator
A8C77_RS18190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8C77_RS18195	COG1733	regulation of RNA biosynthetic process
A8C77_RS18200	COG1733	regulation of RNA biosynthetic process
A8C77_RS18215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C77_RS18235	COG0384	phenazine biosynthesis protein PhzF
A8C77_RS18245	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS18255	COG0318	PFAM AMP-dependent synthetase and ligase
A8C77_RS18265	COG1733	regulation of RNA biosynthetic process
A8C77_RS18300	COG1191	sigma factor activity
A8C77_RS18315	COG1309	transcriptional regulator
A8C77_RS18335	COG3152	Membrane
A8C77_RS18360	COG1151	hydroxylamine reductase activity
A8C77_RS18370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C77_RS18375	COG3409	Peptidoglycan-binding domain 1 protein
A8C77_RS18375	COG3757	hydrolase, family 25
A8C77_RS18410	COG2072	flavoprotein involved in K transport
A8C77_RS18450	COG1113	amino acid transport
A8C77_RS18455	COG2814	Major facilitator Superfamily
A8C77_RS18490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8C77_RS18495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A8C77_RS18515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8C77_RS18525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C77_RS18530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C77_RS18535	COG3739	integral membrane protein
A8C77_RS18540	COG0384	phenazine biosynthesis protein PhzF
A8C77_RS18570	COG0583	DNA-binding transcription factor activity
A8C77_RS18590	COG1193	negative regulation of DNA recombination
A8C77_RS18605	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A8C77_RS18610	COG1164	Oligoendopeptidase f
A8C77_RS18615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8C77_RS18645	COG0584	glycerophosphoryl diester phosphodiesterase
A8C77_RS18670	COG0640	Transcriptional regulator
A8C77_RS18675	COG0604	alcohol dehydrogenase
A8C77_RS18695	COG2808	Putative FMN-binding domain
A8C77_RS18700	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A8C77_RS18710	COG0385	Bile acid
A8C77_RS18715	COG0277	FAD linked oxidase domain protein
A8C77_RS18750	COG1216	Glycosyl transferase, family 2
A8C77_RS18755	COG1024	Enoyl-CoA hydratase
A8C77_RS18765	COG1285	pathogenesis
A8C77_RS18775	COG2514	catechol 2,3-dioxygenase activity
A8C77_RS18780	COG2720	vancomycin resistance protein
A8C77_RS18820	COG0716	FMN binding
A8C77_RS18850	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS18860	COG0165	Argininosuccinate lyase
A8C77_RS18875	COG4145	pantothenate transmembrane transporter activity
A8C77_RS18885	COG1012	belongs to the aldehyde dehydrogenase family
A8C77_RS18890	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS18900	COG1657	PFAM Prenyltransferase squalene oxidase
A8C77_RS18905	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A8C77_RS18910	COG2962	Rard protein
A8C77_RS18915	COG3326	Membrane
A8C77_RS18930	COG0489	protein tyrosine kinase activity
A8C77_RS18940	COG0314	molybdopterin synthase activity
A8C77_RS18945	COG0303	'Molybdopterin
A8C77_RS18950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8C77_RS18955	COG2116	formate transmembrane transporter activity
A8C77_RS18965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A8C77_RS18970	COG5609	conserved protein (DUF2294)
A8C77_RS18975	COG2427	Protein of unknown function (DUF1641)
A8C77_RS18980	COG3383	formate dehydrogenase (NAD+) activity
A8C77_RS18990	COG0697	spore germination
A8C77_RS19030	COG2226	methyltransferase
A8C77_RS19035	COG4166	transmembrane transport
A8C77_RS19040	COG4166	transmembrane transport
A8C77_RS19045	COG4166	transmembrane transport
A8C77_RS19055	COG1316	TRANSCRIPTIONal
A8C77_RS19065	COG1595	DNA-templated transcription, initiation
A8C77_RS19090	COG1131	(ABC) transporter
A8C77_RS19100	COG0673	inositol 2-dehydrogenase activity
A8C77_RS19105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8C77_RS19110	COG0187	DNA topoisomerase II activity
A8C77_RS19120	COG1832	CoA-binding protein
A8C77_RS19125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C77_RS19130	COG0745	RESPONSE REGULATOR receiver
A8C77_RS19145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A8C77_RS19150	COG4841	protein insertion into membrane
A8C77_RS19155	COG0824	Thioesterase
A8C77_RS19185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C77_RS19195	COG2274	protein secretion by the type I secretion system
A8C77_RS19200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8C77_RS19230	COG2211	Major facilitator Superfamily
A8C77_RS19240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8C77_RS19255	COG0183	Belongs to the thiolase family
A8C77_RS19260	COG0318	PFAM AMP-dependent synthetase and ligase
A8C77_RS19265	COG1268	BioY protein
A8C77_RS19270	COG0318	PFAM AMP-dependent synthetase and ligase
A8C77_RS19315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8C77_RS19325	COG5002	protein histidine kinase activity
A8C77_RS19330	COG0400	carboxylic ester hydrolase activity
A8C77_RS19335	COG0346	lactoylglutathione lyase activity
A8C77_RS19340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8C77_RS19345	COG0069	glutamate synthase activity
A8C77_RS19350	COG1902	pentaerythritol trinitrate reductase activity
A8C77_RS19355	COG1329	Transcriptional regulator
A8C77_RS19360	COG0010	Belongs to the arginase family
A8C77_RS19385	COG2226	methyltransferase
A8C77_RS19440	COG4846	Membrane protein involved in cytochrome C biogenesis
A8C77_RS19445	COG0785	Cytochrome C biogenesis protein
A8C77_RS19455	COG0583	DNA-binding transcription factor activity
A8C77_RS19460	COG1380	Effector of murein hydrolase LrgA
A8C77_RS19465	COG1346	cytolysis
A8C77_RS19480	COG0730	response to heat
A8C77_RS19490	COG5632	N-Acetylmuramoyl-L-alanine amidase
A8C77_RS19490	COG3409	Peptidoglycan-binding domain 1 protein
A8C77_RS19505	COG1132	(ABC) transporter
A8C77_RS19510	COG1132	(ABC) transporter
A8C77_RS19545	COG3639	organic phosphonate transmembrane transporter activity
A8C77_RS19550	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A8C77_RS19565	COG0737	Belongs to the 5'-nucleotidase family
A8C77_RS19575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A8C77_RS19595	COG1695	Transcriptional regulator
A8C77_RS19630	COG5632	N-Acetylmuramoyl-L-alanine amidase
A8C77_RS19630	COG1388	LysM domain
A8C77_RS19630	COG3409	Peptidoglycan-binding domain 1 protein
A8C77_RS19635	COG4824	toxin secretion phage lysis holin
A8C77_RS19800	COG1595	DNA-templated transcription, initiation
A8C77_RS19845	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A8C77_RS19925	COG1396	sequence-specific DNA binding
A8C77_RS19950	COG0174	glutamine synthetase
A8C77_RS19955	COG0789	Transcriptional regulator
A8C77_RS19960	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A8C77_RS19970	COG2860	membrane
A8C77_RS19975	COG0464	growth
A8C77_RS20005	COG3584	3D domain protein
A8C77_RS20005	COG1388	LysM domain
A8C77_RS20010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8C77_RS20010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8C77_RS20010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8C77_RS20015	COG1105	Belongs to the carbohydrate kinase PfkB family
A8C77_RS20020	COG1349	DNA-binding transcription factor activity
A8C77_RS20030	COG2322	membrane
A8C77_RS20045	COG1113	amino acid transport
A8C77_RS20055	COG1408	metallophosphoesterase
A8C77_RS20060	COG2116	formate transmembrane transporter activity
A8C77_RS20070	COG2217	Heavy metal translocating P-type atpase
A8C77_RS20075	COG2608	mercury ion transmembrane transporter activity
A8C77_RS20080	COG1937	Protein conserved in bacteria
A8C77_RS20090	COG2819	hydrolase of the alpha beta superfamily
A8C77_RS20095	COG1120	ATPase activity
A8C77_RS20100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C77_RS20105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C77_RS20110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8C77_RS20120	COG0708	Exodeoxyribonuclease III
A8C77_RS20125	COG2169	Transcriptional regulator
A8C77_RS20130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8C77_RS20135	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A8C77_RS20145	COG2364	Membrane
A8C77_RS20160	COG2267	carboxylic ester hydrolase activity
A8C77_RS20165	COG0346	lactoylglutathione lyase activity
A8C77_RS20170	COG5001	Diguanylate cyclase
A8C77_RS20170	COG3300	MHYT domain
A8C77_RS20190	COG1346	cytolysis
A8C77_RS20195	COG1380	Effector of murein hydrolase LrgA
A8C77_RS20200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C77_RS20205	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8C77_RS20205	COG0596	Alpha beta hydrolase
A8C77_RS20210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8C77_RS20225	COG1404	Belongs to the peptidase S8 family
A8C77_RS20230	COG3773	Cell wall hydrolase
A8C77_RS20235	COG0562	UDP-galactopyranose mutase
A8C77_RS20240	COG1368	sulfuric ester hydrolase activity
A8C77_RS20245	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A8C77_RS20255	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A8C77_RS20280	COG1131	(ABC) transporter
A8C77_RS20300	COG4550	Control of competence regulator ComK, YlbF/YmcA
A8C77_RS20305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8C77_RS20310	COG1013	pyruvate-flavodoxin oxidoreductase activity
A8C77_RS20315	COG0674	pyruvate-flavodoxin oxidoreductase activity
A8C77_RS20315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A8C77_RS20325	COG2359	stage V sporulation protein S
A8C77_RS20330	COG1692	metallophosphoesterase
A8C77_RS20355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A8C77_RS20360	COG1426	Protein conserved in bacteria
A8C77_RS20375	COG0300	oxidoreductase activity
A8C77_RS20380	COG0612	Peptidase, M16
A8C77_RS20385	COG0612	Peptidase, M16
A8C77_RS20395	COG4603	Belongs to the binding-protein-dependent transport system permease family
A8C77_RS20400	COG4603	Belongs to the binding-protein-dependent transport system permease family
A8C77_RS20405	COG3845	ABC transporter
A8C77_RS20410	COG1744	ABC transporter substrate-binding protein PnrA-like
A8C77_RS20415	COG2188	Transcriptional regulator
A8C77_RS20420	COG1674	ftsk spoiiie
A8C77_RS20430	COG0740	serine-type endopeptidase activity
A8C77_RS20435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A8C77_RS20450	COG0527	aspartate kinase activity
A8C77_RS20455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8C77_RS20460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A8C77_RS20465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8C77_RS20470	COG1873	PFAM PRC-barrel domain
A8C77_RS20475	COG0612	Peptidase, M16
A8C77_RS20480	COG0726	polysaccharide deacetylase
A8C77_RS20495	COG0196	riboflavin kinase activity
A8C77_RS20500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A8C77_RS20510	COG1550	Protein conserved in bacteria
A8C77_RS20520	COG1358	cellular component organization or biogenesis
A8C77_RS20525	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A8C77_RS20530	COG0195	Participates in both transcription termination and antitermination
A8C77_RS20550	COG0750	zinc metalloprotease
A8C77_RS20560	COG4589	Belongs to the CDS family
A8C77_RS20565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8C77_RS20575	COG0528	UMP kinase activity
A8C77_RS20605	COG4974	Belongs to the 'phage' integrase family
A8C77_RS20615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8C77_RS20625	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A8C77_RS20665	COG1837	Belongs to the UPF0109 family
A8C77_RS20675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A8C77_RS20685	COG0552	protein localization to endoplasmic reticulum
A8C77_RS20690	COG1196	nuclear chromosome segregation
A8C77_RS20700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8C77_RS20705	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS20710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A8C77_RS20725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A8C77_RS20730	COG1461	Dihydroxyacetone kinase
A8C77_RS20735	COG1302	Protein conserved in bacteria
A8C77_RS20750	COG1564	THIamine pyrophosphokinase
A8C77_RS20755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8C77_RS20760	COG1162	GTPase activity
A8C77_RS20765	COG0515	serine threonine protein kinase
A8C77_RS20765	COG2815	serine threonine protein kinase
A8C77_RS20770	COG0631	protein serine/threonine phosphatase activity
A8C77_RS20780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8C77_RS20780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8C77_RS20790	COG0242	peptide deformylase activity
A8C77_RS20795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A8C77_RS20800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A8C77_RS20820	COG1561	YicC-like family, N-terminal region
A8C77_RS20825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A8C77_RS20835	COG0006	proline dipeptidase activity
A8C77_RS20850	COG3069	C4-dicarboxylate transmembrane transporter activity
A8C77_RS20915	COG0564	pseudouridine synthase activity
A8C77_RS20935	COG3599	regulation of cell shape
A8C77_RS20940	COG2302	S4 RNA-binding domain
A8C77_RS20945	COG0762	integral membrane protein
A8C77_RS20955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A8C77_RS20960	COG1496	oxidoreductase activity
A8C77_RS20965	COG1873	PFAM PRC-barrel domain
A8C77_RS20970	COG1191	sigma factor activity
A8C77_RS20975	COG1191	sigma factor activity
A8C77_RS20985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A8C77_RS20990	COG0849	cell division
A8C77_RS20995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A8C77_RS21000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A8C77_RS21010	COG0772	Belongs to the SEDS family
A8C77_RS21025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8C77_RS21030	COG0768	penicillin binding
A8C77_RS21035	COG0768	penicillin binding
A8C77_RS21040	COG4839	cell division protein FtsL
A8C77_RS21055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8C77_RS21070	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A8C77_RS21075	COG1399	metal-binding, possibly nucleic acid-binding protein
A8C77_RS21125	COG4824	toxin secretion phage lysis holin
A8C77_RS21220	COG4626	Terminase
A8C77_RS21220	COG1802	Transcriptional regulator
A8C77_RS21245	COG0582	viral genome integration into host DNA
A8C77_RS21310	COG0756	dUTP diphosphatase activity
A8C77_RS21320	COG1191	sigma factor activity
A8C77_RS21345	COG1484	DNA-dependent DNA replication
A8C77_RS21375	COG1396	sequence-specific DNA binding
A8C77_RS21385	COG1396	sequence-specific DNA binding
A8C77_RS21400	COG0582	viral genome integration into host DNA
A8C77_RS21410	COG3480	Lon protease (S16) C-terminal proteolytic domain
A8C77_RS21415	COG1752	Esterase of the alpha-beta hydrolase superfamily
A8C77_RS21420	COG3314	Sporulation integral membrane protein YlbJ
A8C77_RS21430	COG0742	ribosomal rna small subunit methyltransferase
A8C77_RS21445	COG3679	Belongs to the UPF0342 family
A8C77_RS21450	COG0406	alpha-ribazole phosphatase activity
A8C77_RS21465	COG2340	Cysteine-rich secretory protein family
A8C77_RS21480	COG3336	cytochrome c oxidase
A8C77_RS21515	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A8C77_RS21520	COG0772	Belongs to the SEDS family
A8C77_RS21530	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A8C77_RS21535	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A8C77_RS21545	COG4896	Protein conserved in bacteria
A8C77_RS21560	COG1217	gtp-binding protein TYPA
A8C77_RS21570	COG0483	inositol monophosphate 1-phosphatase activity
A8C77_RS21590	COG1982	Orn Lys Arg decarboxylase major
A8C77_RS21635	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8C77_RS21640	COG0022	dehydrogenase e1 component
A8C77_RS21645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8C77_RS21655	COG0242	peptide deformylase activity
A8C77_RS21660	COG0561	phosphatase activity
A8C77_RS21670	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A8C77_RS21675	COG0569	domain protein
A8C77_RS21695	COG0583	DNA-binding transcription factor activity
A8C77_RS21700	COG0517	IMP dehydrogenase activity
A8C77_RS21710	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A8C77_RS21720	COG4703	Protein of unknown function (DUF1797)
A8C77_RS21735	COG2200	EAL domain
A8C77_RS21740	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS21745	COG1408	metallophosphoesterase
A8C77_RS21755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A8C77_RS21795	COG2814	Major facilitator Superfamily
A8C77_RS21815	COG3209	COG3209 Rhs family protein
A8C77_RS21825	COG2205	protein histidine kinase activity
A8C77_RS21835	COG0436	Aminotransferase
A8C77_RS21840	COG1609	Transcriptional regulator
A8C77_RS21845	COG3833	ABC-type maltose transport systems, permease component
A8C77_RS21850	COG1175	transmembrane transport
A8C77_RS21855	COG2182	Extracellular solute-binding protein
A8C77_RS21865	COG0366	Alpha amylase catalytic
A8C77_RS21870	COG3842	ATPase activity
A8C77_RS21910	COG0183	Belongs to the thiolase family
A8C77_RS21950	COG1695	Transcriptional regulator
A8C77_RS21955	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS21965	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A8C77_RS21975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8C77_RS21980	COG0436	Aminotransferase
A8C77_RS22000	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A8C77_RS22020	COG2199	diguanylate cyclase activity
A8C77_RS22025	COG0778	Nitroreductase
A8C77_RS22050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8C77_RS22050	COG2190	(PTS) system
A8C77_RS22050	COG1263	PTS System
A8C77_RS22055	COG3711	transcriptional antiterminator
A8C77_RS22065	COG2188	Transcriptional regulator
A8C77_RS22075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A8C77_RS22105	COG1547	Domain of unknown function (DUF309)
A8C77_RS22110	COG0456	acetyltransferase
A8C77_RS22120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A8C77_RS22125	COG4086	secreted protein
A8C77_RS22130	COG0561	phosphatase activity
A8C77_RS22135	COG0697	spore germination
A8C77_RS22150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8C77_RS22175	COG0733	neurotransmitter:sodium symporter activity
A8C77_RS22195	COG1686	Belongs to the peptidase S11 family
A8C77_RS22200	COG1725	Transcriptional regulator
A8C77_RS22205	COG1131	(ABC) transporter
A8C77_RS22225	COG1846	Transcriptional regulator
A8C77_RS22240	COG0598	Magnesium transport protein CorA
A8C77_RS22265	COG4974	Belongs to the 'phage' integrase family
A8C77_RS22275	COG0735	belongs to the Fur family
A8C77_RS22280	COG1300	Membrane
A8C77_RS22300	COG0667	Aldo Keto reductase
A8C77_RS22305	COG0656	L-ascorbic acid biosynthetic process
A8C77_RS22310	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A8C77_RS22310	COG0456	acetyltransferase
A8C77_RS22320	COG4085	toxin activity
A8C77_RS22320	COG0737	Belongs to the 5'-nucleotidase family
A8C77_RS22320	COG1525	nuclease
A8C77_RS22330	COG0596	Alpha beta hydrolase
A8C77_RS22335	COG2056	Na+-H+ antiporter family
A8C77_RS22340	COG1609	Transcriptional regulator
A8C77_RS22345	COG0456	acetyltransferase
A8C77_RS22350	COG1073	alpha beta
A8C77_RS22365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8C77_RS22365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8C77_RS22370	COG0307	riboflavin synthase, alpha
A8C77_RS22395	COG4106	trans-aconitate 2-methyltransferase activity
A8C77_RS22400	COG2226	methyltransferase
A8C77_RS22400	COG1073	alpha beta
A8C77_RS22415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8C77_RS22425	COG1757	Na H antiporter
A8C77_RS22430	COG0737	Belongs to the 5'-nucleotidase family
A8C77_RS22440	COG1522	sequence-specific DNA binding
A8C77_RS22460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8C77_RS22470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A8C77_RS22485	COG0300	oxidoreductase activity
A8C77_RS22490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C77_RS22500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8C77_RS22505	COG1760	l-serine dehydratase
A8C77_RS22510	COG1760	l-serine dehydratase
A8C77_RS22530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8C77_RS22540	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8C77_RS22545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8C77_RS22560	COG1376	ErfK ybiS ycfS ynhG family protein
A8C77_RS22565	COG4129	membrane
A8C77_RS22570	COG1126	abc transporter atp-binding protein
A8C77_RS22575	COG0765	amino acid transport
A8C77_RS22580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8C77_RS22595	COG2816	NAD+ diphosphatase activity
A8C77_RS22600	COG0772	Belongs to the SEDS family
A8C77_RS22610	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8C77_RS22615	COG0022	dehydrogenase e1 component
A8C77_RS22620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8C77_RS22625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8C77_RS22640	COG0280	phosphate acetyltransferase
A8C77_RS22650	COG3290	protein histidine kinase activity
A8C77_RS22650	COG3829	transcription factor binding
A8C77_RS22660	COG0584	glycerophosphoryl diester phosphodiesterase
A8C77_RS22665	COG3093	addiction module antidote protein HigA
A8C77_RS22675	COG0745	RESPONSE REGULATOR receiver
A8C77_RS22685	COG0750	zinc metalloprotease
A8C77_RS22690	COG0497	DNA recombination
A8C77_RS22700	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A8C77_RS22710	COG0142	geranyltranstransferase activity
A8C77_RS22735	COG1302	Protein conserved in bacteria
A8C77_RS22740	COG0439	Biotin carboxylase
A8C77_RS22745	COG0511	ligase activity, forming carbon-carbon bonds
A8C77_RS22790	COG3854	ATPases associated with a variety of cellular activities
A8C77_RS22815	COG0006	proline dipeptidase activity
A8C77_RS22830	COG3872	metal-dependent enzyme
A8C77_RS22840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8C77_RS22860	COG0095	Lipoate-protein ligase
A8C77_RS22865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8C77_RS22870	COG1609	Transcriptional regulator
A8C77_RS22880	COG2076	Multidrug Resistance protein
A8C77_RS22885	COG2076	Multidrug Resistance protein
A8C77_RS22925	COG1131	(ABC) transporter
A8C77_RS22930	COG1725	Transcriptional regulator
A8C77_RS22960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8C77_RS23015	COG4970	Tfp pilus assembly protein FimT
A8C77_RS23025	COG1459	type II secretion system
A8C77_RS23030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A8C77_RS23080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8C77_RS23085	COG1410	methionine synthase
A8C77_RS23085	COG0646	methionine synthase
A8C77_RS23090	COG0646	methionine synthase
A8C77_RS23090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A8C77_RS23095	COG0626	cystathionine gamma-synthase activity
A8C77_RS23100	COG0626	cystathionine gamma-synthase activity
A8C77_RS23125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C77_RS23135	COG1940	carbohydrate kinase activity
A8C77_RS23140	COG4483	Protein conserved in bacteria
A8C77_RS23145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A8C77_RS23150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8C77_RS23155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A8C77_RS23160	COG0704	Plays a role in the regulation of phosphate uptake
A8C77_RS23170	COG0581	inorganic phosphate transmembrane transporter activity
A8C77_RS23175	COG0573	inorganic phosphate transmembrane transporter activity
A8C77_RS23180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A8C77_RS23185	COG0768	penicillin binding
A8C77_RS23190	COG0477	Major facilitator Superfamily
A8C77_RS23195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8C77_RS23220	COG0735	belongs to the Fur family
A8C77_RS23225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8C77_RS23230	COG1121	(ABC) transporter
A8C77_RS23235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8C77_RS23265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A8C77_RS23270	COG2384	SAM-dependent methyltransferase
A8C77_RS23275	COG2010	Cytochrome c
A8C77_RS23280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8C77_RS23285	COG0358	DNA primase activity
A8C77_RS23305	COG0517	IMP dehydrogenase activity
A8C77_RS23320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8C77_RS23325	COG0295	cytidine deaminase activity
A8C77_RS23330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A8C77_RS23340	COG1480	7TM receptor with intracellular HD hydrolase
A8C77_RS23345	COG1702	phosphate starvation-inducible protein PhoH
A8C77_RS23365	COG1610	YqeY-like protein
A8C77_RS23370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A8C77_RS23375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8C77_RS23380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A8C77_RS23410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8C77_RS23415	COG1733	regulation of RNA biosynthetic process
A8C77_RS23440	COG1466	dna polymerase III delta subunit
A8C77_RS23450	COG2333	competence protein COMEC
A8C77_RS23450	COG0658	competence protein
A8C77_RS23455	COG2131	deaminase
A8C77_RS23460	COG1555	photosystem II stabilization
A8C77_RS23460	COG1596	polysaccharide export
A8C77_RS23465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8C77_RS23470	COG2226	methyltransferase
A8C77_RS23475	COG0799	negative regulation of ribosome biogenesis
A8C77_RS23480	COG1713	HD superfamily hydrolase involved in NAD metabolism
A8C77_RS23490	COG1534	Rna-binding protein
A8C77_RS23500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A8C77_RS23505	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A8C77_RS23530	COG1595	DNA-templated transcription, initiation
A8C77_RS23540	COG0778	Nitroreductase
A8C77_RS23545	COG2357	RelA SpoT domain protein
A8C77_RS23555	COG1785	Belongs to the alkaline phosphatase family
A8C77_RS23565	COG2267	carboxylic ester hydrolase activity
A8C77_RS23600	COG1404	Belongs to the peptidase S8 family
A8C77_RS23605	COG3186	Phenylalanine-4-hydroxylase
A8C77_RS23615	COG2514	catechol 2,3-dioxygenase activity
A8C77_RS23620	COG2514	catechol 2,3-dioxygenase activity
A8C77_RS23625	COG2259	Doxx family
A8C77_RS23665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8C77_RS23675	COG1454	alcohol dehydrogenase
A8C77_RS23675	COG1012	belongs to the aldehyde dehydrogenase family
A8C77_RS23680	COG0626	cystathionine gamma-synthase activity
A8C77_RS23685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8C77_RS23710	COG0768	penicillin binding
A8C77_RS23725	COG0826	peptidase U32
A8C77_RS23730	COG0826	peptidase U32
A8C77_RS23735	COG4122	O-methyltransferase activity
A8C77_RS23740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8C77_RS23760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8C77_RS23770	COG0628	permease
A8C77_RS23790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8C77_RS23800	COG0482	sulfurtransferase activity
A8C77_RS23805	COG1104	cysteine desulfurase activity
A8C77_RS23810	COG1959	2 iron, 2 sulfur cluster binding
A8C77_RS23815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8C77_RS23825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A8C77_RS23850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8C77_RS23860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A8C77_RS23860	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A8C77_RS23865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8C77_RS23870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8C77_RS23870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8C77_RS23880	COG2244	polysaccharide biosynthetic process
A8C77_RS23885	COG2323	membrane
A8C77_RS23895	COG1862	Preprotein translocase
A8C77_RS23925	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A8C77_RS23935	COG0697	spore germination
A8C77_RS23940	COG0697	spore germination
A8C77_RS23945	COG0640	Transcriptional regulator
A8C77_RS23970	COG0157	Belongs to the NadC ModD family
A8C77_RS23975	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A8C77_RS23980	COG1104	cysteine desulfurase activity
A8C77_RS23985	COG1827	regulation of RNA biosynthetic process
A8C77_RS23990	COG2258	MOSC domain
A8C77_RS23995	COG0077	Prephenate dehydratase
A8C77_RS24000	COG0577	efflux transmembrane transporter activity
A8C77_RS24005	COG0577	efflux transmembrane transporter activity
A8C77_RS24010	COG1136	(ABC) transporter
A8C77_RS24015	COG5002	protein histidine kinase activity
A8C77_RS24025	COG0745	RESPONSE REGULATOR receiver
A8C77_RS24030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A8C77_RS24035	COG3290	protein histidine kinase activity
A8C77_RS24045	COG2868	ribosomal protein
A8C77_RS24055	COG1530	ribonuclease E activity
A8C77_RS24060	COG1994	Peptidase M50
A8C77_RS24065	COG0739	heme binding
A8C77_RS24070	COG2894	cell division
A8C77_RS24090	COG1077	Cell shape determining protein MreB Mrl
A8C77_RS24110	COG0285	dihydrofolate synthase activity
A8C77_RS24115	COG0525	valine-tRNA ligase activity
A8C77_RS24125	COG1388	LysM domain
A8C77_RS24135	COG0113	porphobilinogen synthase activity
A8C77_RS24140	COG1587	Uroporphyrinogen-III synthase
A8C77_RS24150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8C77_RS24160	COG1846	Transcriptional regulator
A8C77_RS24165	COG1764	response to oxidative stress
A8C77_RS24180	COG0470	DNA polymerase III
A8C77_RS24180	COG1067	ATP-dependent peptidase activity
A8C77_RS24235	COG0622	Phosphoesterase
A8C77_RS24250	COG5401	PFAM Sporulation and spore germination
A8C77_RS24270	COG1309	transcriptional regulator
A8C77_RS24285	COG2197	response regulator
A8C77_RS24290	COG2233	PERMEase
A8C77_RS24300	COG0402	S-adenosylhomocysteine deaminase activity
A8C77_RS24305	COG0402	S-adenosylhomocysteine deaminase activity
A8C77_RS24315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C77_RS24325	COG0444	Belongs to the ABC transporter superfamily
A8C77_RS24330	COG4608	Belongs to the ABC transporter superfamily
A8C77_RS24335	COG3275	phosphorelay sensor kinase activity
A8C77_RS24340	COG3279	Response regulator of the LytR AlgR family
A8C77_RS24355	COG1983	PspC domain protein
A8C77_RS24360	COG1396	sequence-specific DNA binding
A8C77_RS24365	COG0697	spore germination
A8C77_RS24375	COG1959	2 iron, 2 sulfur cluster binding
A8C77_RS24380	COG1668	transmembrane transport
A8C77_RS24385	COG4152	abc transporter atp-binding protein
A8C77_RS24390	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A8C77_RS24400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A8C77_RS24405	COG1876	peptidase activity
A8C77_RS24410	COG0824	Thioesterase
A8C77_RS24415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A8C77_RS24420	COG1053	succinate dehydrogenase
A8C77_RS24425	COG2009	succinate dehydrogenase
A8C77_RS24430	COG1719	4-vinyl reductase, 4VR
A8C77_RS24440	COG3118	belongs to the thioredoxin family
A8C77_RS24445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A8C77_RS24450	COG2086	electron transfer activity
A8C77_RS24455	COG1024	Enoyl-CoA hydratase
A8C77_RS24460	COG1309	transcriptional regulator
A8C77_RS24465	COG0318	PFAM AMP-dependent synthetase and ligase
A8C77_RS24485	COG2318	DinB family
A8C77_RS24515	COG1131	(ABC) transporter
A8C77_RS24520	COG2205	protein histidine kinase activity
A8C77_RS24525	COG0745	RESPONSE REGULATOR receiver
A8C77_RS24535	COG4895	conserved protein (DUF2196)
A8C77_RS24540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A8C77_RS24555	COG4509	Sortase family
A8C77_RS24560	COG1120	ATPase activity
A8C77_RS24575	COG5386	Cell surface protein
A8C77_RS24585	COG5386	Cell surface protein
A8C77_RS24590	COG1114	Component of the transport system for branched-chain amino acids
A8C77_RS24595	COG1187	pseudouridine synthase activity
A8C77_RS24610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A8C77_RS24610	COG1796	DNA polymerase
A8C77_RS24615	COG1286	toxin biosynthetic process
A8C77_RS24660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8C77_RS24670	COG1418	mRNA catabolic process
A8C77_RS24695	COG2814	Major facilitator Superfamily
A8C77_RS24700	COG1566	PFAM secretion protein HlyD family protein
A8C77_RS24705	COG1309	transcriptional regulator
A8C77_RS24710	COG1363	Peptidase, m42
A8C77_RS24735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8C77_RS24745	COG1484	DNA-dependent DNA replication
A8C77_RS24750	COG3611	Membrane attachment protein
A8C77_RS24760	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A8C77_RS24765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8C77_RS24770	COG0237	dephospho-CoA kinase activity
A8C77_RS24775	COG1971	Probably functions as a manganese efflux pump
A8C77_RS24785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8C77_RS24785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8C77_RS24790	COG5002	protein histidine kinase activity
A8C77_RS24795	COG0745	RESPONSE REGULATOR receiver
A8C77_RS24815	COG0538	isocitrate dehydrogenase activity
A8C77_RS24820	COG0372	Belongs to the citrate synthase family
A8C77_RS24835	COG0628	permease
A8C77_RS24840	COG3030	protein affecting phage T7 exclusion by the F plasmid
A8C77_RS24865	COG1725	Transcriptional regulator
A8C77_RS24870	COG0281	malic enzyme
A8C77_RS24875	COG0587	DNA-directed DNA polymerase activity
A8C77_RS24890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A8C77_RS24910	COG4109	DRTGG domain
A8C77_RS24925	COG0006	proline dipeptidase activity
A8C77_RS24960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8C77_RS24965	COG0662	Cupin 2, conserved barrel domain protein
A8C77_RS24975	COG1476	TRANSCRIPTIONal
A8C77_RS24990	COG1028	Short-chain dehydrogenase reductase Sdr
A8C77_RS24995	COG0589	response to stress
A8C77_RS25035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8C77_RS25055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A8C77_RS25060	COG0827	DNA restriction-modification system
A8C77_RS25065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A8C77_RS25070	COG3874	Sporulation protein YtfJ
A8C77_RS25085	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A8C77_RS25095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8C77_RS25110	COG1104	cysteine desulfurase activity
A8C77_RS25120	COG0583	DNA-binding transcription factor activity
A8C77_RS25125	COG0697	spore germination
A8C77_RS25135	COG1956	GAF domain-containing protein
A8C77_RS25140	COG0626	cystathionine gamma-synthase activity
A8C77_RS25170	COG1595	DNA-templated transcription, initiation
A8C77_RS25180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8C77_RS25185	COG0454	-acetyltransferase
A8C77_RS25190	COG0517	IMP dehydrogenase activity
A8C77_RS25195	COG0123	including yeast histone deacetylase and acetoin utilization protein
A8C77_RS25205	COG0745	RESPONSE REGULATOR receiver
A8C77_RS25215	COG0666	response to abiotic stimulus
A8C77_RS25250	COG1609	Transcriptional regulator
A8C77_RS25260	COG4851	CamS sex pheromone cAM373 precursor
A8C77_RS25265	COG3118	belongs to the thioredoxin family
A8C77_RS25275	COG2309	aminopeptidase activity
A8C77_RS25295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8C77_RS25310	COG1674	ftsk spoiiie
A8C77_RS25320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8C77_RS25325	COG4848	Belongs to the UPF0354 family
A8C77_RS25330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C77_RS25335	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A8C77_RS25340	COG1363	Peptidase, m42
A8C77_RS25350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C77_RS25365	COG0510	thiamine kinase activity
A8C77_RS25370	COG1523	belongs to the glycosyl hydrolase 13 family
A8C77_RS25385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8C77_RS25390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8C77_RS25395	COG1349	DNA-binding transcription factor activity
A8C77_RS25400	COG1187	pseudouridine synthase activity
A8C77_RS25405	COG2244	polysaccharide biosynthetic process
A8C77_RS25410	COG2081	HI0933 family
A8C77_RS25415	COG2814	Major facilitator Superfamily
A8C77_RS25425	COG3832	glyoxalase III activity
A8C77_RS25445	COG1329	Transcriptional regulator
A8C77_RS25455	COG4975	Glucose uptake
A8C77_RS25470	COG0314	molybdopterin synthase activity
A8C77_RS25475	COG1763	Mo-molybdopterin cofactor biosynthetic process
A8C77_RS25480	COG0303	'Molybdopterin
A8C77_RS25490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8C77_RS25515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8C77_RS25525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8C77_RS25570	COG2814	Major facilitator Superfamily
A8C77_RS25575	COG0475	glutathione-regulated potassium exporter activity
A8C77_RS25580	COG0490	domain, Protein
A8C77_RS25585	COG0582	viral genome integration into host DNA
A8C77_RS25595	COG1136	(ABC) transporter
A8C77_RS25615	COG1242	4 iron, 4 sulfur cluster binding
A8C77_RS25620	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A8C77_RS25625	COG1131	(ABC) transporter
A8C77_RS25635	COG1794	racemase activity, acting on amino acids and derivatives
A8C77_RS25655	COG2267	carboxylic ester hydrolase activity
A8C77_RS25660	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A8C77_RS25665	COG0671	phosphoesterase, PA-phosphatase related
A8C77_RS25670	COG0438	transferase activity, transferring glycosyl groups
A8C77_RS25680	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8C77_RS25735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A8C77_RS25740	COG5002	protein histidine kinase activity
A8C77_RS25745	COG4191	Histidine kinase
A8C77_RS25750	COG2267	carboxylic ester hydrolase activity
A8C77_RS25770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8C77_RS25775	COG1116	anion transmembrane transporter activity
A8C77_RS25780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8C77_RS25805	COG0494	nUDIX hydrolase
A8C77_RS25835	COG0288	reversible hydration of carbon dioxide
A8C77_RS25840	COG1271	oxidase subunit
A8C77_RS25845	COG1294	oxidase, subunit
A8C77_RS25865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8C77_RS25890	COG1842	Phage shock protein A
A8C77_RS25925	COG5002	protein histidine kinase activity
A8C77_RS25930	COG0745	RESPONSE REGULATOR receiver
A8C77_RS25960	COG1597	lipid kinase activity
A8C77_RS25995	COG0586	Pfam SNARE associated Golgi protein
A8C77_RS26005	COG0577	efflux transmembrane transporter activity
A8C77_RS26010	COG1136	(ABC) transporter
A8C77_RS26015	COG2207	Transcriptional regulator
A8C77_RS26015	COG3708	Transcriptional regulator
A8C77_RS26020	COG0745	RESPONSE REGULATOR receiver
A8C77_RS26025	COG2205	protein histidine kinase activity
A8C77_RS26030	COG0577	efflux transmembrane transporter activity
A8C77_RS26040	COG0577	efflux transmembrane transporter activity
A8C77_RS26045	COG1136	(ABC) transporter
A8C77_RS26065	COG2188	Transcriptional regulator
A8C77_RS26085	COG3964	amidohydrolase
A8C77_RS26115	COG4948	Mandelate Racemase Muconate Lactonizing
A8C77_RS26125	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A8C77_RS26130	COG0596	Alpha beta hydrolase
A8C77_RS26135	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A8C77_RS26140	COG1169	isochorismate synthase
A8C77_RS26145	COG1575	Belongs to the MenA family. Type 1 subfamily
A8C77_RS26150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A8C77_RS26175	COG0058	SHG alpha-glucan phosphorylase activity
A8C77_RS26180	COG0297	glycogen (starch) synthase activity
A8C77_RS26185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A8C77_RS26295	COG0544	peptidyl-prolyl cis-trans isomerase activity
A8C77_RS26330	COG1285	pathogenesis
A8C77_RS26335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8C77_RS26345	COG0166	Belongs to the GPI family
A8C77_RS26355	COG2155	Conserved Protein
A8C77_RS26360	COG1098	S1 RNA binding domain
A8C77_RS26365	COG0436	Aminotransferase
A8C77_RS26370	COG1522	sequence-specific DNA binding
A8C77_RS26375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8C77_RS26380	COG2267	carboxylic ester hydrolase activity
A8C77_RS26390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A8C77_RS26410	COG5018	Exonuclease
A8C77_RS26415	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A8C77_RS26435	COG2050	protein possibly involved in aromatic compounds catabolism
A8C77_RS26445	COG1268	BioY protein
A8C77_RS26455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8C77_RS26460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8C77_RS26475	COG3584	3D domain protein
A8C77_RS26490	COG1252	NADH dehydrogenase
A8C77_RS26505	COG3708	Transcriptional regulator
A8C77_RS26520	COG1683	Conserved Protein
A8C77_RS26540	COG0316	Belongs to the HesB IscA family
A8C77_RS26555	COG1252	NADH dehydrogenase
A8C77_RS26570	COG0390	transport system, permease component
A8C77_RS26575	COG2824	Alkylphosphonate utilization operon protein PhnA
A8C77_RS26615	COG4837	Protein of unknown function (DUF1462)
A8C77_RS26620	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A8C77_RS26630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8C77_RS26635	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A8C77_RS26650	COG2249	NAD(P)H dehydrogenase (quinone) activity
A8C77_RS26655	COG0647	UMP catabolic process
A8C77_RS26665	COG2445	Protein of unknown function DUF86
A8C77_RS26670	COG1494	fructose-1,6-bisphosphatase
A8C77_RS26690	COG4470	Protein conserved in bacteria
A8C77_RS26700	COG0789	Transcriptional regulator
A8C77_RS26705	COG4377	Putative membrane peptidase family (DUF2324)
A8C77_RS26730	COG0739	heme binding
A8C77_RS26740	COG3377	Domain of unknown function (DUF1805)
A8C77_RS26745	COG0737	Belongs to the 5'-nucleotidase family
A8C77_RS26755	COG1695	Transcriptional regulator
A8C77_RS26770	COG0719	Fe-S assembly protein
A8C77_RS26775	COG0822	iron-sulfur transferase activity
A8C77_RS26780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8C77_RS26785	COG0719	Fe-S assembly protein
A8C77_RS26790	COG0396	ATPase activity
A8C77_RS26795	COG1464	Belongs to the NlpA lipoprotein family
A8C77_RS26800	COG1464	Belongs to the NlpA lipoprotein family
A8C77_RS26805	COG2011	ABC-type metal ion transport system permease component
A8C77_RS26810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8C77_RS26825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C77_RS26830	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A8C77_RS26840	COG1393	Belongs to the ArsC family
A8C77_RS26890	COG0039	L-malate dehydrogenase activity
A8C77_RS26910	COG1309	transcriptional regulator
A8C77_RS26915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C77_RS26920	COG1960	acyl-CoA dehydrogenase activity
A8C77_RS26925	COG0183	Belongs to the thiolase family
A8C77_RS26930	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8C77_RS26930	COG1024	Enoyl-CoA hydratase
A8C77_RS26940	COG1686	Belongs to the peptidase S11 family
A8C77_RS26955	COG0011	TIGRFAM Protein of
A8C77_RS26960	COG0840	transmembrane signaling receptor activity
A8C77_RS26980	COG2814	Major facilitator Superfamily
A8C77_RS26985	COG0531	amino acid
A8C77_RS26995	COG0706	membrane insertase activity
A8C77_RS27005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8C77_RS27040	COG0586	Pfam SNARE associated Golgi protein
A8C77_RS27050	COG1376	ErfK ybiS ycfS ynhG family protein
A8C77_RS27055	COG0745	RESPONSE REGULATOR receiver
A8C77_RS27060	COG5002	protein histidine kinase activity
A8C77_RS27085	COG2151	metal-sulfur cluster biosynthetic enzyme
A8C77_RS27090	COG3227	Zinc metalloprotease (Elastase)
A8C77_RS27095	COG1741	Belongs to the pirin family
A8C77_RS27110	COG0475	glutathione-regulated potassium exporter activity
A8C77_RS27115	COG0490	domain, Protein
A8C77_RS27125	COG1115	amino acid carrier protein
A8C77_RS27130	COG0783	Belongs to the Dps family
A8C77_RS27145	COG1611	Belongs to the LOG family
A8C77_RS27160	COG2311	Membrane
A8C77_RS27170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8C77_RS27175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8C77_RS27180	COG1115	amino acid carrier protein
A8C77_RS27185	COG1115	amino acid carrier protein
A8C77_RS27190	COG2910	NAD(P)H-binding
A8C77_RS27205	COG0656	L-ascorbic acid biosynthetic process
A8C77_RS27210	COG2814	Major facilitator Superfamily
A8C77_RS27215	COG1733	regulation of RNA biosynthetic process
A8C77_RS27225	COG1252	NADH dehydrogenase
A8C77_RS27230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A8C77_RS27235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A8C77_RS27245	COG3290	protein histidine kinase activity
A8C77_RS27245	COG0840	transmembrane signaling receptor activity
A8C77_RS27255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8C77_RS27260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8C77_RS27275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8C77_RS27330	COG0557	exoribonuclease II activity
A8C77_RS27335	COG1647	Serine aminopeptidase, S33
A8C77_RS27340	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8C77_RS27345	COG1346	cytolysis
A8C77_RS27445	COG4695	Portal protein
A8C77_RS27470	COG4974	Belongs to the 'phage' integrase family
A8C77_RS27480	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A8C77_RS27485	COG0149	triose-phosphate isomerase activity
A8C77_RS27495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8C77_RS27510	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A8C77_RS27535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8C77_RS27550	COG2323	membrane
A8C77_RS27555	COG0740	serine-type endopeptidase activity
A8C77_RS27560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8C77_RS27570	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A8C77_RS27580	COG1051	belongs to the nudix hydrolase family
A8C77_RS27590	COG0492	ferredoxin-NADP+ reductase activity
A8C77_RS27595	COG0457	Tetratricopeptide repeat
A8C77_RS27600	COG0110	maltose O-acetyltransferase activity
A8C77_RS27620	COG1950	PFAM Membrane protein of
A8C77_RS27630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8C77_RS27635	COG0556	nucleotide-excision repair
A8C77_RS27655	COG0789	Transcriptional regulator
A8C77_RS27680	COG2855	membrane
A8C77_RS27685	COG0583	DNA-binding transcription factor activity
A8C77_RS27695	COG0655	NAD(P)H dehydrogenase (quinone) activity
A8C77_RS27700	COG0488	(ABC) transporter
A8C77_RS27710	COG1132	(ABC) transporter
A8C77_RS27715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C77_RS27720	COG0793	Belongs to the peptidase S41A family
A8C77_RS27720	COG3409	Peptidoglycan-binding domain 1 protein
A8C77_RS27725	COG2177	Part of the ABC transporter FtsEX involved in
A8C77_RS27730	COG2884	Cell division ATP-binding protein ftsE
A8C77_RS27745	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A8C77_RS27750	COG0653	protein targeting
A8C77_RS27755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A8C77_RS27760	COG1278	Cold shock
A8C77_RS27765	COG1040	competence protein
A8C77_RS27770	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A8C77_RS27775	COG1388	LysM domain
A8C77_RS27775	COG0791	NLP P60 protein
A8C77_RS27780	COG1733	regulation of RNA biosynthetic process
A8C77_RS27790	COG1307	EDD domain protein, DegV family
A8C77_RS27795	COG1739	Uncharacterized protein family UPF0029
A8C77_RS27800	COG1316	TRANSCRIPTIONal
A8C77_RS27805	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A8C77_RS27810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8C77_RS27815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8C77_RS27825	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A8C77_RS27825	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A8C77_RS27840	COG3394	polysaccharide catabolic process
A8C77_RS27845	COG1486	melibiose metabolic process
A8C77_RS27850	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8C77_RS27855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8C77_RS27865	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A8C77_RS27870	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A8C77_RS27875	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8C77_RS27885	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8C77_RS27890	COG1301	dicarboxylic acid transport
A8C77_RS27900	COG0346	lactoylglutathione lyase activity
A8C77_RS27905	COG1511	domain protein
A8C77_RS27910	COG0583	DNA-binding transcription factor activity
A8C77_RS27915	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A8C77_RS27935	COG1271	oxidase subunit
A8C77_RS27940	COG1294	oxidase, subunit
A8C77_RS27945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A8C77_RS27955	COG1620	l-lactate permease
A8C77_RS27965	COG2389	metal-binding protein
A8C77_RS27975	COG1368	sulfuric ester hydrolase activity
A8C77_RS27990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8C77_RS28010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8C77_RS28015	COG3584	3D domain protein
A8C77_RS28015	COG1388	LysM domain
A8C77_RS28040	COG4715	Zinc finger, swim domain protein
A8C77_RS28045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8C77_RS28085	COG0577	efflux transmembrane transporter activity
A8C77_RS28090	COG1136	(ABC) transporter
A8C77_RS28125	COG5002	protein histidine kinase activity
A8C77_RS28130	COG0745	RESPONSE REGULATOR receiver
A8C77_RS28135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8C77_RS28150	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A8C77_RS28155	COG1134	teichoic acid transport
A8C77_RS28160	COG1682	transport, permease protein
A8C77_RS28165	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8C77_RS28210	COG1609	Transcriptional regulator
A8C77_RS28225	COG0739	heme binding
A8C77_RS28240	COG3279	Response regulator of the LytR AlgR family
A8C77_RS28245	COG4555	ABC transporter
A8C77_RS28250	COG2385	sporulation resulting in formation of a cellular spore
A8C77_RS28265	COG4836	Membrane
A8C77_RS28270	COG1007	ATP synthesis coupled electron transport
A8C77_RS28275	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8C77_RS28280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8C77_RS28290	COG0839	Belongs to the complex I subunit 6 family
A8C77_RS28305	COG0649	NAD binding
A8C77_RS28310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8C77_RS28325	COG3300	MHYT domain
A8C77_RS28325	COG5001	Diguanylate cyclase
A8C77_RS28375	COG0356	it plays a direct role in the translocation of protons across the membrane
A8C77_RS28410	COG0698	ribose 5-phosphate isomerase
A8C77_RS28420	COG2190	(PTS) system
A8C77_RS28425	COG2259	Doxx family
A8C77_RS28430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8C77_RS28445	COG0009	L-threonylcarbamoyladenylate synthase
A8C77_RS28460	COG2890	protein-(glutamine-N5) methyltransferase activity
A8C77_RS28480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A8C77_RS28485	COG1494	fructose-1,6-bisphosphatase
A8C77_RS28505	COG4821	SIS domain
A8C77_RS28515	COG3343	RNA polymerase activity
A8C77_RS28525	COG1960	acyl-CoA dehydrogenase activity
A8C77_RS28530	COG1960	acyl-CoA dehydrogenase activity
A8C77_RS28535	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8C77_RS28540	COG0183	Belongs to the thiolase family
A8C77_RS28545	COG2181	nitrate reductase activity
A8C77_RS28545	COG0247	lactate metabolic process
A8C77_RS28550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8C77_RS28560	COG3300	MHYT domain
A8C77_RS28560	COG5001	Diguanylate cyclase
A8C77_RS28575	COG2197	response regulator
A8C77_RS28580	COG4585	Histidine kinase
A8C77_RS28585	COG0842	Transport permease protein
A8C77_RS28590	COG1131	(ABC) transporter
A8C77_RS28595	COG0024	Methionine aminopeptidase
A8C77_RS28615	COG2234	aminopeptidase activity
A8C77_RS28635	COG1595	DNA-templated transcription, initiation
A8C77_RS28640	COG0018	arginyl-trna synthetase
A8C77_RS28645	COG4506	Protein conserved in bacteria
A8C77_RS28650	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8C77_RS28665	COG0010	Belongs to the arginase family
A8C77_RS28675	COG2814	Major facilitator Superfamily
A8C77_RS28680	COG0789	Transcriptional regulator
A8C77_RS28685	COG0584	glycerophosphoryl diester phosphodiesterase
A8C77_RS28690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8C77_RS28700	COG1994	Peptidase M50
A8C77_RS28710	COG1078	dGTPase activity
A8C77_RS28715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8C77_RS28720	COG1120	ATPase activity
A8C77_RS28725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C77_RS28730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C77_RS28735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8C77_RS28755	COG0095	Lipoate-protein ligase
A8C77_RS28760	COG0280	phosphate acetyltransferase
A8C77_RS28775	COG3773	Cell wall hydrolase
A8C77_RS28785	COG2363	Small membrane protein
A8C77_RS28800	COG2233	PERMEase
A8C77_RS28805	COG0561	phosphatase activity
A8C77_RS28810	COG2814	Major facilitator Superfamily
A8C77_RS28820	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A8C77_RS28825	COG1131	(ABC) transporter
A8C77_RS28830	COG2755	lipolytic protein G-D-S-L family
A8C77_RS28835	COG1609	Transcriptional regulator
A8C77_RS28845	COG0460	homoserine dehydrogenase
A8C77_RS28855	COG2873	o-acetylhomoserine
A8C77_RS28865	COG1011	Hydrolase
A8C77_RS28870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8C77_RS28880	COG2197	response regulator
A8C77_RS28890	COG0351	phosphomethylpyrimidine kinase
A8C77_RS28895	COG3706	GGDEF domain
A8C77_RS28900	COG2879	small protein
A8C77_RS28905	COG1966	Carbon starvation protein
A8C77_RS28910	COG3279	Response regulator of the LytR AlgR family
A8C77_RS28915	COG0477	Major facilitator Superfamily
A8C77_RS28940	COG0840	transmembrane signaling receptor activity
A8C77_RS28950	COG1607	acyl-coa hydrolase
A8C77_RS28965	COG0488	(ABC) transporter
A8C77_RS28990	COG0463	Glycosyl transferase, family 2
A8C77_RS28995	COG1309	transcriptional regulator
A8C77_RS29000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8C77_RS29005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8C77_RS29005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8C77_RS29010	COG0628	permease
A8C77_RS29025	COG3279	Response regulator of the LytR AlgR family
A8C77_RS29030	COG3275	phosphorelay sensor kinase activity
A8C77_RS29035	COG2814	Major facilitator Superfamily
A8C77_RS29040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A8C77_RS29045	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A8C77_RS29050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8C77_RS29070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8C77_RS29075	COG1272	protein, Hemolysin III
A8C77_RS29095	COG0516	GMP reductase activity
A8C77_RS29100	COG1164	Oligoendopeptidase f
A8C77_RS29120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C77_RS29125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A8C77_RS29130	COG4853	Protein conserved in bacteria
A8C77_RS29135	COG4863	YycH protein
A8C77_RS29140	COG5002	protein histidine kinase activity
A8C77_RS29145	COG0745	RESPONSE REGULATOR receiver
A8C77_RS29175	COG0305	Participates in initiation and elongation during chromosome replication
A8C77_RS29185	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A8C77_RS29190	COG4241	membrane
A8C77_RS29200	COG0629	single-stranded DNA binding
A8C77_RS29210	COG0012	GTP binding
A8C77_RS29215	COG4481	Protein conserved in bacteria
A8C77_RS29220	COG0668	transmembrane transport
A8C77_RS29230	COG1475	DNA binding
A8C77_RS29235	COG1192	Involved in chromosome partitioning
A8C77_RS29260	COG1847	R3H domain protein
A8C77_RS29265	COG0706	membrane insertase activity
A8C77_RS29275	COG0230	Belongs to the bacterial ribosomal protein bL34 family