locus-tag	class	description
A16_RS00010	COG0592	DNA-directed DNA polymerase activity
A16_RS00015	COG2501	S4 domain
A16_RS00025	COG0187	DNA topoisomerase II activity
A16_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A16_RS00055	COG0516	GMP reductase activity
A16_RS00055	COG0517	IMP dehydrogenase activity
A16_RS00060	COG1686	Belongs to the peptidase S11 family
A16_RS00090	COG1428	Deoxynucleoside kinase
A16_RS00095	COG1428	Deoxynucleoside kinase
A16_RS00100	COG1335	isochorismatase
A16_RS00110	COG0590	tRNA wobble adenosine to inosine editing
A16_RS00115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A16_RS00170	COG1982	Orn Lys Arg decarboxylase major
A16_RS00180	COG0470	DNA polymerase III
A16_RS00185	COG1774	PSP1 C-terminal conserved region
A16_RS00195	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A16_RS00205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A16_RS00210	COG2002	toxin-antitoxin pair type II binding
A16_RS00215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16_RS00215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16_RS00220	COG0084	hydrolase, TatD family'
A16_RS00225	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A16_RS00240	COG4466	Protein conserved in bacteria
A16_RS00255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A16_RS00260	COG0251	oxidation-reduction process
A16_RS00290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A16_RS00295	COG2002	toxin-antitoxin pair type II binding
A16_RS00300	COG2244	polysaccharide biosynthetic process
A16_RS00305	COG3956	TIGRFAM MazG family protein
A16_RS00310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A16_RS00330	COG1098	S1 RNA binding domain
A16_RS00345	COG2208	phosphoserine phosphatase activity
A16_RS00350	COG0037	tRNA processing
A16_RS00355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A16_RS00360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A16_RS00375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A16_RS00380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A16_RS00385	COG0512	Glutamine amidotransferase of anthranilate synthase
A16_RS00390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16_RS00395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A16_RS00400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A16_RS00405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A16_RS00410	COG1396	sequence-specific DNA binding
A16_RS00415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A16_RS00445	COG3880	PFAM UvrB UvrC protein
A16_RS00460	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A16_RS00470	COG4956	integral membrane protein (PIN domain superfamily)
A16_RS00490	COG1045	serine acetyltransferase
A16_RS00505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A16_RS00510	COG3688	RNA-binding protein containing a PIN domain
A16_RS00525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A16_RS00530	COG0250	Participates in transcription elongation, termination and antitermination
A16_RS00535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A16_RS00555	COG2813	Specifically methylates the guanine in position
A16_RS00565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A16_RS00570	COG1358	cellular component organization or biogenesis
A16_RS00640	COG0255	Belongs to the universal ribosomal protein uL29 family
A16_RS00700	COG0201	protein transport
A16_RS00710	COG0024	Methionine aminopeptidase
A16_RS00720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A16_RS00755	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A16_RS00780	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16_RS00785	COG0489	protein tyrosine kinase activity
A16_RS00795	COG2194	sulfuric ester hydrolase activity
A16_RS00800	COG0726	polysaccharide deacetylase
A16_RS00885	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A16_RS00905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A16_RS00910	COG0596	Alpha beta hydrolase
A16_RS00930	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A16_RS00935	COG0823	Involved in the tonB-independent uptake of proteins
A16_RS00935	COG4946	Tricorn protease homolog
A16_RS00935	COG1506	peptidase
A16_RS00970	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS00975	COG2011	ABC-type metal ion transport system permease component
A16_RS00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A16_RS00985	COG1464	Belongs to the NlpA lipoprotein family
A16_RS00990	COG0604	alcohol dehydrogenase
A16_RS01000	COG0277	FAD linked oxidase domain protein
A16_RS01005	COG2271	Major facilitator Superfamily
A16_RS01015	COG2814	Major facilitator Superfamily
A16_RS01030	COG0601	transmembrane transport
A16_RS01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16_RS01040	COG0444	Belongs to the ABC transporter superfamily
A16_RS01045	COG4608	Belongs to the ABC transporter superfamily
A16_RS01050	COG4166	transmembrane transport
A16_RS01060	COG2207	Transcriptional regulator
A16_RS01075	COG4166	transmembrane transport
A16_RS01080	COG4166	transmembrane transport
A16_RS01085	COG0656	L-ascorbic acid biosynthetic process
A16_RS01090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16_RS01110	COG4149	molybdate abc transporter
A16_RS01115	COG0725	ABC transporter, periplasmic molybdate-binding protein
A16_RS01120	COG0725	ABC transporter, periplasmic molybdate-binding protein
A16_RS01125	COG1910	domain protein
A16_RS01140	COG0583	DNA-binding transcription factor activity
A16_RS01145	COG0697	spore germination
A16_RS01155	COG0204	Acyl-transferase
A16_RS01165	COG1609	Transcriptional regulator
A16_RS01175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_RS01190	COG0084	hydrolase, TatD family'
A16_RS01195	COG5298	Protein conserved in bacteria
A16_RS01220	COG0488	(ABC) transporter
A16_RS01235	COG0747	negative chemotaxis
A16_RS01240	COG0601	transmembrane transport
A16_RS01245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16_RS01250	COG0444	Belongs to the ABC transporter superfamily
A16_RS01255	COG4608	Belongs to the ABC transporter superfamily
A16_RS01280	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A16_RS01285	COG0179	Fumarylacetoacetate (FAA) hydrolase
A16_RS01295	COG2814	Major facilitator Superfamily
A16_RS01310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A16_RS01320	COG4294	response to UV
A16_RS01325	COG0705	Rhomboid family
A16_RS01325	COG0457	Tetratricopeptide repeat
A16_RS01335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A16_RS01340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A16_RS01345	COG0864	Transcriptional regulator
A16_RS01350	COG2337	Toxic component of a toxin-antitoxin (TA) module
A16_RS01355	COG2183	response to ionizing radiation
A16_RS01450	COG0802	atpase or kinase
A16_RS01455	COG1214	PFAM Peptidase M22, glycoprotease
A16_RS01460	COG0456	acetyltransferase
A16_RS01470	COG0488	(ABC) transporter
A16_RS01485	COG1266	CAAX protease self-immunity
A16_RS01505	COG2252	PERMEase
A16_RS01515	COG5002	protein histidine kinase activity
A16_RS01545	COG2226	methyltransferase
A16_RS01585	COG1968	undecaprenyl-diphosphatase activity
A16_RS01600	COG2205	protein histidine kinase activity
A16_RS01605	COG0745	RESPONSE REGULATOR receiver
A16_RS01625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A16_RS01630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A16_RS01635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A16_RS01645	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A16_RS01660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A16_RS01670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A16_RS01680	COG0151	Belongs to the GarS family
A16_RS01705	COG0210	DNA helicase
A16_RS01715	COG4851	CamS sex pheromone cAM373 precursor
A16_RS01735	COG1335	isochorismatase
A16_RS01740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A16_RS01745	COG2011	ABC-type metal ion transport system permease component
A16_RS01750	COG1464	Belongs to the NlpA lipoprotein family
A16_RS01770	COG1846	Transcriptional regulator
A16_RS01795	COG1597	lipid kinase activity
A16_RS01800	COG0546	phosphoglycolate phosphatase activity
A16_RS01805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A16_RS01815	COG1012	belongs to the aldehyde dehydrogenase family
A16_RS01820	COG2076	Multidrug Resistance protein
A16_RS01825	COG2309	aminopeptidase activity
A16_RS01840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_RS01845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A16_RS01850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A16_RS01860	COG4807	Protein conserved in bacteria
A16_RS01885	COG1757	Na H antiporter
A16_RS01890	COG1473	amidohydrolase
A16_RS01905	COG0450	alkyl hydroperoxide reductase
A16_RS01925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_RS01930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_RS01935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_RS01955	COG0166	Belongs to the GPI family
A16_RS01990	COG5002	protein histidine kinase activity
A16_RS02010	COG3541	Predicted nucleotidyltransferase
A16_RS02015	COG2814	Major facilitator Superfamily
A16_RS02020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16_RS02020	COG0723	plastoquinol--plastocyanin reductase activity
A16_RS02030	COG0765	amino acid transport
A16_RS02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16_RS02050	COG0840	transmembrane signaling receptor activity
A16_RS02055	COG0840	transmembrane signaling receptor activity
A16_RS02060	COG0366	Alpha amylase catalytic
A16_RS02065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_RS02065	COG1263	PTS System
A16_RS02065	COG2190	(PTS) system
A16_RS02095	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A16_RS02110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16_RS02120	COG1116	anion transmembrane transporter activity
A16_RS02125	COG0488	(ABC) transporter
A16_RS02170	COG2270	Major facilitator Superfamily
A16_RS02185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A16_RS02200	COG2310	stress, protein
A16_RS02205	COG2310	stress, protein
A16_RS02210	COG2310	stress, protein
A16_RS02215	COG0861	Integral membrane protein TerC family
A16_RS02225	COG3853	Toxic anion resistance protein (TelA)
A16_RS02240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A16_RS02250	COG1295	ribonuclease BN
A16_RS02255	COG2217	Heavy metal translocating P-type atpase
A16_RS02260	COG0697	spore germination
A16_RS02280	COG0586	Pfam SNARE associated Golgi protein
A16_RS02295	COG3871	stress protein (general stress protein 26)
A16_RS02300	COG0387	Pfam Sodium calcium exchanger
A16_RS02310	COG0535	radical SAM domain protein
A16_RS02335	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A16_RS02340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A16_RS02345	COG0582	viral genome integration into host DNA
A16_RS02350	COG1396	sequence-specific DNA binding
A16_RS02365	COG1396	sequence-specific DNA binding
A16_RS02400	COG1484	DNA-dependent DNA replication
A16_RS02495	COG0582	viral genome integration into host DNA
A16_RS02500	COG0582	viral genome integration into host DNA
A16_RS02625	COG0101	tRNA pseudouridine synthase activity
A16_RS02635	COG3829	transcription factor binding
A16_RS02645	COG0833	amino acid
A16_RS02650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A16_RS02685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_RS02685	COG1263	PTS System
A16_RS02690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16_RS02705	COG0463	Glycosyl transferase, family 2
A16_RS02720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A16_RS02720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A16_RS02740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A16_RS02760	COG1228	amidohydrolase
A16_RS02765	COG1090	epimerase
A16_RS02795	COG1988	membrane-bound metal-dependent
A16_RS02800	COG1194	a g-specific adenine glycosylase
A16_RS02825	COG1132	(ABC) transporter
A16_RS02830	COG4129	membrane
A16_RS02835	COG0070	glutamate synthase
A16_RS02835	COG0069	glutamate synthase activity
A16_RS02835	COG0067	glutamate synthase
A16_RS02845	COG4555	ABC transporter
A16_RS02865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A16_RS02870	COG0735	belongs to the Fur family
A16_RS02985	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A16_RS02990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A16_RS03000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A16_RS03010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A16_RS03015	COG5001	Diguanylate cyclase
A16_RS03015	COG1716	ATPase activity
A16_RS03025	COG2766	serine protein kinase
A16_RS03050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A16_RS03060	COG1585	Membrane protein implicated in regulation of membrane protease activity
A16_RS03065	COG2268	Band 7 protein
A16_RS03075	COG3290	protein histidine kinase activity
A16_RS03085	COG2851	Citrate transporter
A16_RS03105	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A16_RS03110	COG3842	ATPase activity
A16_RS03115	COG1175	transmembrane transport
A16_RS03120	COG0395	ABC-type sugar transport system, permease component
A16_RS03130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A16_RS03135	COG0745	RESPONSE REGULATOR receiver
A16_RS03140	COG5002	protein histidine kinase activity
A16_RS03150	COG4990	cell redox homeostasis
A16_RS03160	COG3290	protein histidine kinase activity
A16_RS03165	COG4565	transcriptional regulatory protein
A16_RS03170	COG3493	citrate carrier protein
A16_RS03175	COG0281	malic enzyme
A16_RS03190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_RS03200	COG5002	protein histidine kinase activity
A16_RS03205	COG0745	RESPONSE REGULATOR receiver
A16_RS03215	COG0454	-acetyltransferase
A16_RS03215	COG0456	acetyltransferase
A16_RS03220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A16_RS03225	COG3383	formate dehydrogenase (NAD+) activity
A16_RS03230	COG2427	Protein of unknown function (DUF1641)
A16_RS03245	COG0531	amino acid
A16_RS03250	COG0640	Transcriptional regulator
A16_RS03255	COG2217	Heavy metal translocating P-type atpase
A16_RS03260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A16_RS03270	COG3227	Zinc metalloprotease (Elastase)
A16_RS03290	COG2720	vancomycin resistance protein
A16_RS03295	COG1316	TRANSCRIPTIONal
A16_RS03300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_RS03305	COG0346	lactoylglutathione lyase activity
A16_RS03310	COG1253	flavin adenine dinucleotide binding
A16_RS03315	COG1027	Aspartate ammonia-lyase
A16_RS03320	COG1620	l-lactate permease
A16_RS03335	COG3104	oligopeptide transport
A16_RS03340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_RS03345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_RS03350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_RS03365	COG0156	8-amino-7-oxononanoate synthase activity
A16_RS03370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A16_RS03385	COG0714	Associated with various cellular activities
A16_RS03390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16_RS03410	COG0531	amino acid
A16_RS03420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_RS03420	COG1263	PTS System
A16_RS03440	COG0697	spore germination
A16_RS03450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A16_RS03455	COG1115	amino acid carrier protein
A16_RS03460	COG1126	abc transporter atp-binding protein
A16_RS03465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16_RS03470	COG0765	amino acid transport
A16_RS03475	COG0765	amino acid transport
A16_RS03480	COG0833	amino acid
A16_RS03505	COG2378	regulation of single-species biofilm formation
A16_RS03510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A16_RS03515	COG5002	protein histidine kinase activity
A16_RS03530	COG0659	secondary active sulfate transmembrane transporter activity
A16_RS03545	COG0747	negative chemotaxis
A16_RS03555	COG0601	transmembrane transport
A16_RS03560	COG4608	Belongs to the ABC transporter superfamily
A16_RS03570	COG2271	Major facilitator Superfamily
A16_RS03575	COG1846	Transcriptional regulator
A16_RS03580	COG0477	Major facilitator Superfamily
A16_RS03585	COG0477	Major facilitator Superfamily
A16_RS03595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A16_RS03610	COG1172	Belongs to the binding-protein-dependent transport system permease family
A16_RS03615	COG1879	ABC-type sugar transport system periplasmic component
A16_RS03640	COG1063	alcohol dehydrogenase
A16_RS03655	COG3568	Endonuclease Exonuclease Phosphatase
A16_RS03680	COG1968	undecaprenyl-diphosphatase activity
A16_RS03685	COG0840	transmembrane signaling receptor activity
A16_RS03690	COG3584	3D domain protein
A16_RS03690	COG1388	LysM domain
A16_RS03695	COG1476	TRANSCRIPTIONal
A16_RS03710	COG3104	oligopeptide transport
A16_RS03715	COG1114	Component of the transport system for branched-chain amino acids
A16_RS03730	COG1113	amino acid transport
A16_RS03735	COG2252	PERMEase
A16_RS03760	COG0475	glutathione-regulated potassium exporter activity
A16_RS03760	COG0569	domain protein
A16_RS03775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A16_RS03780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A16_RS03785	COG0833	amino acid
A16_RS03790	COG4990	cell redox homeostasis
A16_RS03805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16_RS03810	COG0697	spore germination
A16_RS03815	COG0531	amino acid
A16_RS03830	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A16_RS03835	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A16_RS03840	COG1918	ferrous iron import across plasma membrane
A16_RS03840	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A16_RS03845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A16_RS03850	COG0573	inorganic phosphate transmembrane transporter activity
A16_RS03855	COG0581	inorganic phosphate transmembrane transporter activity
A16_RS03865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A16_RS03980	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A16_RS04005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A16_RS04010	COG1116	anion transmembrane transporter activity
A16_RS04015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16_RS04020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A16_RS04025	COG0352	thiamine-phosphate diphosphorylase activity
A16_RS04030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16_RS04035	COG2104	thiamine diphosphate biosynthetic process
A16_RS04045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16_RS04050	COG0351	phosphomethylpyrimidine kinase
A16_RS04095	COG2205	protein histidine kinase activity
A16_RS04100	COG2814	Major facilitator Superfamily
A16_RS04105	COG1846	Transcriptional regulator
A16_RS04120	COG2252	PERMEase
A16_RS04125	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS04140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A16_RS04145	COG1621	beta-fructofuranosidase activity
A16_RS04150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_RS04150	COG1263	PTS System
A16_RS04155	COG1609	Transcriptional regulator
A16_RS04165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16_RS04170	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A16_RS04210	COG0778	Nitroreductase
A16_RS04215	COG2719	SpoVR family
A16_RS04240	COG0446	pyridine nucleotide-disulphide oxidoreductase
A16_RS04245	COG1937	Protein conserved in bacteria
A16_RS04250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_RS04250	COG0425	Belongs to the sulfur carrier protein TusA family
A16_RS04255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_RS04255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_RS04260	COG0425	Belongs to the sulfur carrier protein TusA family
A16_RS04265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_RS04275	COG2210	Belongs to the sulfur carrier protein TusA family
A16_RS04280	COG0730	response to heat
A16_RS04290	COG1316	TRANSCRIPTIONal
A16_RS04295	COG0604	alcohol dehydrogenase
A16_RS04300	COG1283	sodium-dependent phosphate transmembrane transporter activity
A16_RS04315	COG3711	transcriptional antiterminator
A16_RS04315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A16_RS04320	COG1447	Phosphotransferase system cellobiose-specific component IIA
A16_RS04325	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A16_RS04345	COG3584	3D domain protein
A16_RS04345	COG1388	LysM domain
A16_RS04350	COG0577	efflux transmembrane transporter activity
A16_RS04355	COG1136	(ABC) transporter
A16_RS04365	COG5522	Integral membrane protein (intg_mem_TP0381)
A16_RS04380	COG1114	Component of the transport system for branched-chain amino acids
A16_RS04385	COG3546	catalase activity
A16_RS04420	COG0586	Pfam SNARE associated Golgi protein
A16_RS04455	COG0531	amino acid
A16_RS04460	COG0475	glutathione-regulated potassium exporter activity
A16_RS04470	COG1737	Transcriptional regulator
A16_RS04480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_RS04480	COG1263	PTS System
A16_RS04490	COG2259	Doxx family
A16_RS04505	COG0697	spore germination
A16_RS04510	COG1522	sequence-specific DNA binding
A16_RS04525	COG2076	Multidrug Resistance protein
A16_RS04530	COG1309	transcriptional regulator
A16_RS04535	COG2814	Major facilitator Superfamily
A16_RS04540	COG1733	regulation of RNA biosynthetic process
A16_RS04550	COG2249	NAD(P)H dehydrogenase (quinone) activity
A16_RS04555	COG4533	DNA binding
A16_RS04560	COG2211	Major facilitator Superfamily
A16_RS04570	COG0693	protein deglycase activity
A16_RS04575	COG0753	catalase activity
A16_RS04575	COG0693	protein deglycase activity
A16_RS04585	COG0531	amino acid
A16_RS04590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A16_RS04600	COG1012	belongs to the aldehyde dehydrogenase family
A16_RS04610	COG1132	(ABC) transporter
A16_RS04620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16_RS04625	COG0765	amino acid transport
A16_RS04630	COG1126	abc transporter atp-binding protein
A16_RS04645	COG0189	ligase activity
A16_RS04675	COG0028	Belongs to the TPP enzyme family
A16_RS04680	COG3527	Alpha-acetolactate decarboxylase
A16_RS04695	COG0561	phosphatase activity
A16_RS04710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A16_RS04725	COG0659	secondary active sulfate transmembrane transporter activity
A16_RS04750	COG2244	polysaccharide biosynthetic process
A16_RS04760	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16_RS04765	COG4196	transglutaminase domain protein
A16_RS04780	COG1696	Membrane protein involved in D-alanine export
A16_RS04795	COG1024	Enoyl-CoA hydratase
A16_RS04815	COG1363	Peptidase, m42
A16_RS04835	COG3938	Belongs to the proline racemase family
A16_RS04875	COG0601	transmembrane transport
A16_RS04880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16_RS04890	COG4608	Belongs to the ABC transporter superfamily
A16_RS04920	COG0477	Major facilitator Superfamily
A16_RS04925	COG3290	protein histidine kinase activity
A16_RS04930	COG4565	transcriptional regulatory protein
A16_RS04935	COG3181	Tripartite tricarboxylate transporter family receptor
A16_RS04965	COG4978	Transcriptional regulator
A16_RS04965	COG0789	Transcriptional regulator
A16_RS04980	COG0305	Participates in initiation and elongation during chromosome replication
A16_RS05020	COG0477	Major facilitator Superfamily
A16_RS05070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A16_RS05070	COG3320	Male sterility
A16_RS05075	COG1309	transcriptional regulator
A16_RS05095	COG1183	phosphatidylcholine synthase activity
A16_RS05115	COG2376	Dihydroxyacetone kinase
A16_RS05130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A16_RS05135	COG1959	2 iron, 2 sulfur cluster binding
A16_RS05160	COG2770	Histidine kinase
A16_RS05160	COG3437	response regulator, receiver
A16_RS05210	COG3237	CsbD-like
A16_RS05235	COG1191	sigma factor activity
A16_RS05245	COG2208	phosphoserine phosphatase activity
A16_RS05250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A16_RS05255	COG2198	Histidine kinase
A16_RS05255	COG0784	Response regulator, receiver
A16_RS05255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16_RS05255	COG2205	protein histidine kinase activity
A16_RS05315	COG0420	3'-5' exonuclease activity
A16_RS05320	COG4717	serine-type aminopeptidase activity
A16_RS05340	COG1309	transcriptional regulator
A16_RS05345	COG2814	Major facilitator Superfamily
A16_RS05350	COG0346	lactoylglutathione lyase activity
A16_RS05355	COG0346	lactoylglutathione lyase activity
A16_RS05360	COG0457	Tetratricopeptide repeat
A16_RS05365	COG2267	carboxylic ester hydrolase activity
A16_RS05385	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A16_RS05390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A16_RS05400	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A16_RS05440	COG0477	Major facilitator Superfamily
A16_RS05445	COG0477	Major facilitator Superfamily
A16_RS05455	COG3973	AAA domain
A16_RS05460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A16_RS05485	COG4980	gas vesicle protein
A16_RS05490	COG0537	adenosine 5'-monophosphoramidase activity
A16_RS05495	COG1131	(ABC) transporter
A16_RS05500	COG4473	ABC transporter
A16_RS05510	COG1309	transcriptional regulator
A16_RS05520	COG3402	PFAM membrane-flanked domain
A16_RS05530	COG3428	Bacterial PH domain
A16_RS05575	COG3402	PFAM membrane-flanked domain
A16_RS05580	COG3428	Bacterial PH domain
A16_RS05585	COG2329	Antibiotic biosynthesis monooxygenase
A16_RS05590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16_RS05595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A16_RS05600	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A16_RS05605	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A16_RS05640	COG1309	transcriptional regulator
A16_RS05645	COG1511	domain protein
A16_RS05670	COG1609	Transcriptional regulator
A16_RS05680	COG1234	tRNA 3'-trailer cleavage
A16_RS05685	COG0095	Lipoate-protein ligase
A16_RS05695	COG0318	PFAM AMP-dependent synthetase and ligase
A16_RS05725	COG3209	COG3209 Rhs family protein
A16_RS05770	COG1408	metallophosphoesterase
A16_RS05775	COG1078	dGTPase activity
A16_RS05785	COG1595	DNA-templated transcription, initiation
A16_RS05790	COG2207	Transcriptional regulator
A16_RS05790	COG3708	Transcriptional regulator
A16_RS05805	COG2205	protein histidine kinase activity
A16_RS05810	COG0745	RESPONSE REGULATOR receiver
A16_RS05835	COG0501	Belongs to the peptidase M48B family
A16_RS05840	COG0840	transmembrane signaling receptor activity
A16_RS05845	COG0697	spore germination
A16_RS05865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A16_RS05870	COG2224	Isocitrate lyase
A16_RS05895	COG4903	ComK protein
A16_RS05900	COG0398	Pfam SNARE associated Golgi protein
A16_RS05910	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A16_RS05915	COG1074	ATP-dependent DNA helicase activity
A16_RS05960	COG0179	Fumarylacetoacetate (FAA) hydrolase
A16_RS05985	COG0367	asparagine synthase
A16_RS05990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A16_RS05995	COG0753	catalase activity
A16_RS06000	COG0004	ammonium transporteR
A16_RS06025	COG2996	Protein conserved in bacteria
A16_RS06035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A16_RS06045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_RS06060	COG0561	phosphatase activity
A16_RS06075	COG0542	response to heat
A16_RS06085	COG2267	carboxylic ester hydrolase activity
A16_RS06100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16_RS06105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A16_RS06110	COG5504	Zn-dependent protease
A16_RS06120	COG0180	Tryptophanyl-tRNA synthetase
A16_RS06130	COG4166	transmembrane transport
A16_RS06135	COG0601	transmembrane transport
A16_RS06140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16_RS06145	COG0444	Belongs to the ABC transporter superfamily
A16_RS06155	COG0534	Mate efflux family protein
A16_RS06160	COG4166	transmembrane transport
A16_RS06180	COG0861	Integral membrane protein TerC family
A16_RS06185	COG4862	establishment of competence for transformation
A16_RS06190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16_RS06200	COG1164	Oligoendopeptidase f
A16_RS06210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A16_RS06215	COG2346	COG2346, Truncated hemoglobins
A16_RS06220	COG4116	CYTH
A16_RS06230	COG2357	RelA SpoT domain protein
A16_RS06240	COG0564	pseudouridine synthase activity
A16_RS06260	COG0463	Glycosyl transferase, family 2
A16_RS06260	COG1216	Glycosyl transferase, family 2
A16_RS06280	COG0463	Glycosyl transferase, family 2
A16_RS06280	COG0457	Tetratricopeptide repeat
A16_RS06300	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A16_RS06315	COG1091	dTDP-4-dehydrorhamnose reductase activity
A16_RS06360	COG2153	protein acetylation
A16_RS06370	COG2382	esterase
A16_RS06385	COG5492	domain, Protein
A16_RS06390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16_RS06405	COG0512	Glutamine amidotransferase of anthranilate synthase
A16_RS06405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A16_RS06440	COG1620	l-lactate permease
A16_RS06445	COG5634	Uncharacterized conserved protein (DUF2278)
A16_RS06495	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16_RS06505	COG1476	TRANSCRIPTIONal
A16_RS06565	COG2226	methyltransferase
A16_RS06575	COG1686	Belongs to the peptidase S11 family
A16_RS06580	COG0681	Belongs to the peptidase S26 family
A16_RS06615	COG1012	belongs to the aldehyde dehydrogenase family
A16_RS06620	COG3842	ATPase activity
A16_RS06625	COG1176	ABC-type spermidine putrescine transport system, permease component I
A16_RS06630	COG1177	transmembrane transport
A16_RS06635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A16_RS06645	COG2409	Drug exporters of the RND superfamily
A16_RS06655	COG0564	pseudouridine synthase activity
A16_RS06665	COG2340	Cysteine-rich secretory protein family
A16_RS06670	COG0247	lactate metabolic process
A16_RS06675	COG0277	FAD linked oxidase domain protein
A16_RS06680	COG3835	regulator
A16_RS06690	COG0745	RESPONSE REGULATOR receiver
A16_RS06695	COG5002	protein histidine kinase activity
A16_RS06700	COG2186	Transcriptional regulator
A16_RS06720	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A16_RS06730	COG2116	formate transmembrane transporter activity
A16_RS06735	COG0861	Integral membrane protein TerC family
A16_RS06750	COG2030	dehydratase
A16_RS06770	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS06780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16_RS06785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A16_RS06800	COG1840	ABC-type Fe3 transport system, periplasmic component
A16_RS06830	COG1349	DNA-binding transcription factor activity
A16_RS06855	COG2861	carbohydrate metabolic process
A16_RS06865	COG3852	Histidine kinase
A16_RS06870	COG1846	Transcriptional regulator
A16_RS06880	COG2318	DinB family
A16_RS06890	COG5002	protein histidine kinase activity
A16_RS06900	COG0720	synthase
A16_RS06915	COG4873	Protein conserved in bacteria
A16_RS06950	COG1780	Probably involved in ribonucleotide reductase function
A16_RS06965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A16_RS06970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A16_RS06975	COG1725	Transcriptional regulator
A16_RS06980	COG1131	(ABC) transporter
A16_RS06990	COG1131	(ABC) transporter
A16_RS06995	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A16_RS07010	COG1522	sequence-specific DNA binding
A16_RS07020	COG1335	isochorismatase
A16_RS07030	COG1619	proteins homologs of microcin C7 resistance protein MccF
A16_RS07035	COG2070	2-Nitropropane dioxygenase
A16_RS07040	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A16_RS07050	COG1696	Membrane protein involved in D-alanine export
A16_RS07075	COG0716	FMN binding
A16_RS07090	COG3173	Aminoglycoside phosphotransferase
A16_RS07110	COG0534	Mate efflux family protein
A16_RS07115	COG1968	undecaprenyl-diphosphatase activity
A16_RS07130	COG1846	Transcriptional regulator
A16_RS07140	COG1301	dicarboxylic acid transport
A16_RS07145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A16_RS07150	COG4709	membrane
A16_RS07155	COG3874	Sporulation protein YtfJ
A16_RS07185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16_RS07190	COG0028	Belongs to the TPP enzyme family
A16_RS07195	COG0440	acetolactate synthase activity
A16_RS07200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A16_RS07210	COG0473	3-isopropylmalate dehydrogenase activity
A16_RS07235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A16_RS07270	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A16_RS07285	COG1183	phosphatidylcholine synthase activity
A16_RS07300	COG0019	diaminopimelate decarboxylase activity
A16_RS07320	COG0529	Catalyzes the synthesis of activated sulfate
A16_RS07325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A16_RS07345	COG1648	precorrin-2 dehydrogenase activity
A16_RS07355	COG0733	neurotransmitter:sodium symporter activity
A16_RS07375	COG1757	Na H antiporter
A16_RS07390	COG4758	membrane
A16_RS07395	COG4585	Histidine kinase
A16_RS07400	COG2197	response regulator
A16_RS07410	COG1114	Component of the transport system for branched-chain amino acids
A16_RS07420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A16_RS07445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A16_RS07445	COG1017	nitric oxide dioxygenase activity
A16_RS07465	COG0730	response to heat
A16_RS07470	COG0306	phosphate transporter
A16_RS07475	COG1392	Phosphate transport regulator
A16_RS07480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16_RS07495	COG3852	Histidine kinase
A16_RS07500	COG1801	Protein of unknown function DUF72
A16_RS07510	COG0582	viral genome integration into host DNA
A16_RS07515	COG5002	protein histidine kinase activity
A16_RS07535	COG0392	lysyltransferase activity
A16_RS07535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A16_RS07550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A16_RS07555	COG1686	Belongs to the peptidase S11 family
A16_RS07560	COG2715	membrane protein required for spore maturation
A16_RS07565	COG0700	Nucleoside recognition
A16_RS07570	COG1187	pseudouridine synthase activity
A16_RS07580	COG1333	cytochrome c biogenesis protein
A16_RS07585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A16_RS07590	COG0745	RESPONSE REGULATOR receiver
A16_RS07595	COG5002	protein histidine kinase activity
A16_RS07600	COG2096	Adenosyltransferase
A16_RS07615	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A16_RS07620	COG1141	Ferredoxin
A16_RS07625	COG4955	Helix-turn-helix domain
A16_RS07630	COG0514	ATP-dependent DNA helicase (RecQ)
A16_RS07635	COG1266	CAAX protease self-immunity
A16_RS07655	COG4862	establishment of competence for transformation
A16_RS07660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A16_RS07680	COG0492	ferredoxin-NADP+ reductase activity
A16_RS07685	COG0252	asparaginase activity
A16_RS07755	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A16_RS07770	COG0142	geranyltranstransferase activity
A16_RS07780	COG0142	geranyltranstransferase activity
A16_RS07800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A16_RS07805	COG0457	Tetratricopeptide repeat
A16_RS07825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A16_RS07835	COG4347	Protein of unknown function (DUF1405)
A16_RS07850	COG2738	Putative neutral zinc metallopeptidase
A16_RS07860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_RS07870	COG1694	Mazg nucleotide pyrophosphohydrolase
A16_RS07885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A16_RS07890	COG0438	transferase activity, transferring glycosyl groups
A16_RS07930	COG1199	ATP-dependent helicase activity
A16_RS07930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A16_RS07950	COG3935	DnaD domain protein
A16_RS07955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A16_RS07965	COG4499	WXG100 protein secretion system (Wss), protein YukC
A16_RS07965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16_RS08015	COG0116	Belongs to the methyltransferase superfamily
A16_RS08025	COG1199	ATP-dependent helicase activity
A16_RS08030	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A16_RS08040	COG3173	Aminoglycoside phosphotransferase
A16_RS08045	COG0024	Methionine aminopeptidase
A16_RS08055	COG2233	PERMEase
A16_RS08060	COG2311	Membrane
A16_RS08065	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A16_RS08075	COG0456	acetyltransferase
A16_RS08100	COG0754	glutathionylspermidine amidase activity
A16_RS08115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A16_RS08140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A16_RS08155	COG1215	transferase activity, transferring glycosyl groups
A16_RS08160	COG0438	transferase activity, transferring glycosyl groups
A16_RS08175	COG0454	-acetyltransferase
A16_RS08195	COG0328	RNA-DNA hybrid ribonuclease activity
A16_RS08235	COG1280	lysine exporter protein (LysE YggA)
A16_RS08250	COG3162	membrane
A16_RS08255	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16_RS08260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A16_RS08270	COG0475	glutathione-regulated potassium exporter activity
A16_RS08280	COG0789	Transcriptional regulator
A16_RS08280	COG4978	Transcriptional regulator
A16_RS08290	COG2323	membrane
A16_RS08295	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A16_RS08350	COG1923	regulation of RNA biosynthetic process
A16_RS08360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A16_RS08365	COG1360	Flagellar Motor Protein
A16_RS08370	COG2201	protein-glutamate methylesterase activity
A16_RS08380	COG1776	CheC inhibitor of MCP methylation
A16_RS08380	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A16_RS08395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A16_RS08415	COG1256	bacterial-type flagellum assembly
A16_RS08420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A16_RS08445	COG1815	bacterial-type flagellum-dependent cell motility
A16_RS08450	COG1558	bacterial-type flagellum-dependent cell motility
A16_RS08460	COG1766	The M ring may be actively involved in energy transduction
A16_RS08470	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A16_RS08480	COG1157	protein secretion by the type III secretion system
A16_RS08530	COG0463	Glycosyl transferase, family 2
A16_RS08560	COG0463	Glycosyl transferase, family 2
A16_RS08560	COG0457	Tetratricopeptide repeat
A16_RS08585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A16_RS08590	COG0741	lytic transglycosylase activity
A16_RS08605	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A16_RS08605	COG1776	CheC inhibitor of MCP methylation
A16_RS08615	COG1338	Plays a role in the flagellum-specific transport system
A16_RS08620	COG1987	bacterial-type flagellum assembly
A16_RS08630	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A16_RS08635	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A16_RS08645	COG4786	Flagellar basal body rod
A16_RS08650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A16_RS08675	COG1309	transcriptional regulator
A16_RS08695	COG2329	Antibiotic biosynthesis monooxygenase
A16_RS08720	COG0583	DNA-binding transcription factor activity
A16_RS08725	COG3842	ATPase activity
A16_RS08730	COG0725	ABC transporter, periplasmic molybdate-binding protein
A16_RS08740	COG1234	tRNA 3'-trailer cleavage
A16_RS08765	COG1686	Belongs to the peptidase S11 family
A16_RS08775	COG0406	alpha-ribazole phosphatase activity
A16_RS08805	COG0367	asparagine synthase
A16_RS08835	COG1802	Transcriptional regulator
A16_RS08840	COG0697	spore germination
A16_RS08845	COG0523	cobalamin synthesis protein
A16_RS08850	COG0701	Predicted permease
A16_RS08860	COG1216	Glycosyl transferase, family 2
A16_RS08860	COG0438	transferase activity, transferring glycosyl groups
A16_RS08865	COG1757	Na H antiporter
A16_RS08870	COG0114	fumarate hydratase activity
A16_RS08900	COG3340	Belongs to the peptidase S51 family
A16_RS08920	COG0785	Cytochrome C biogenesis protein
A16_RS08955	COG2733	membrane
A16_RS08990	COG1131	(ABC) transporter
A16_RS09010	COG0528	UMP kinase activity
A16_RS09020	COG1027	Aspartate ammonia-lyase
A16_RS09025	COG0281	malic enzyme
A16_RS09030	COG4191	Histidine kinase
A16_RS09035	COG0784	Response regulator, receiver
A16_RS09040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A16_RS09100	COG1051	belongs to the nudix hydrolase family
A16_RS09105	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16_RS09115	COG2814	Major facilitator Superfamily
A16_RS09130	COG1966	Carbon starvation protein
A16_RS09145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16_RS09155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A16_RS09165	COG4166	transmembrane transport
A16_RS09170	COG2223	nitrite transmembrane transporter activity
A16_RS09175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A16_RS09190	COG2244	polysaccharide biosynthetic process
A16_RS09195	COG0733	neurotransmitter:sodium symporter activity
A16_RS09205	COG5566	PFAM Mor transcription activator
A16_RS09210	COG2323	membrane
A16_RS09225	COG2084	Dehydrogenase
A16_RS09240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A16_RS09250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16_RS09255	COG0028	Belongs to the TPP enzyme family
A16_RS09260	COG0440	acetolactate synthase activity
A16_RS09265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A16_RS09275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A16_RS09300	COG2814	Major facilitator Superfamily
A16_RS09305	COG3384	dioxygenase
A16_RS09315	COG3279	Response regulator of the LytR AlgR family
A16_RS09320	COG0427	acetyl-CoA hydrolase
A16_RS09340	COG1073	alpha beta
A16_RS09345	COG4166	transmembrane transport
A16_RS09370	COG0535	radical SAM domain protein
A16_RS09375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_RS09395	COG1914	H( )-stimulated, divalent metal cation uptake system
A16_RS09410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A16_RS09445	COG2390	Transcriptional regulator
A16_RS09455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_RS09460	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A16_RS09475	COG4224	UPF0291 protein
A16_RS09495	COG0006	proline dipeptidase activity
A16_RS09500	COG2132	Multicopper oxidase
A16_RS09530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A16_RS09545	COG2372	response to copper ion
A16_RS09545	COG1276	copper resistance
A16_RS09550	COG4549	nuclear export factor GLE1
A16_RS09560	COG0697	spore germination
A16_RS09565	COG0583	DNA-binding transcription factor activity
A16_RS09570	COG1959	2 iron, 2 sulfur cluster binding
A16_RS09575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A16_RS09580	COG0778	Nitroreductase
A16_RS09595	COG0628	permease
A16_RS09605	COG1231	oxidoreductase activity
A16_RS09610	COG0523	cobalamin synthesis protein
A16_RS09625	COG0318	PFAM AMP-dependent synthetase and ligase
A16_RS09630	COG2030	dehydratase
A16_RS09645	COG0411	ABC transporter
A16_RS09665	COG0583	DNA-binding transcription factor activity
A16_RS09685	COG1846	Transcriptional regulator
A16_RS09695	COG1271	oxidase subunit
A16_RS09700	COG1294	oxidase, subunit
A16_RS09705	COG4988	ABC transporter
A16_RS09710	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A16_RS09730	COG1686	Belongs to the peptidase S11 family
A16_RS09745	COG1388	LysM domain
A16_RS09745	COG0791	NLP P60 protein
A16_RS09755	COG1132	(ABC) transporter
A16_RS09760	COG1132	(ABC) transporter
A16_RS09765	COG0745	RESPONSE REGULATOR receiver
A16_RS09770	COG5002	protein histidine kinase activity
A16_RS09780	COG0300	oxidoreductase activity
A16_RS09815	COG0460	homoserine dehydrogenase
A16_RS09840	COG1316	TRANSCRIPTIONal
A16_RS09850	COG0745	RESPONSE REGULATOR receiver
A16_RS09855	COG5002	protein histidine kinase activity
A16_RS09870	COG1285	pathogenesis
A16_RS09875	COG1247	-acetyltransferase
A16_RS09895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A16_RS09905	COG1082	Xylose isomerase domain protein TIM barrel
A16_RS09920	COG1279	arginine transmembrane transporter activity
A16_RS09930	COG1752	Esterase of the alpha-beta hydrolase superfamily
A16_RS09970	COG2002	toxin-antitoxin pair type II binding
A16_RS09975	COG1404	Belongs to the peptidase S8 family
A16_RS09980	COG0640	Transcriptional regulator
A16_RS09985	COG0667	Aldo Keto reductase
A16_RS09990	COG2814	Major facilitator Superfamily
A16_RS10015	COG0840	transmembrane signaling receptor activity
A16_RS10035	COG3949	Membrane
A16_RS10040	COG0783	Belongs to the Dps family
A16_RS10055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A16_RS10065	COG1231	oxidoreductase activity
A16_RS10075	COG4989	oxidoreductase activity
A16_RS10080	COG0523	cobalamin synthesis protein
A16_RS10085	COG0456	acetyltransferase
A16_RS10150	COG0803	Belongs to the bacterial solute-binding protein 9 family
A16_RS10150	COG3443	Belongs to the bacterial solute-binding protein 9 family
A16_RS10160	COG0702	epimerase
A16_RS10170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A16_RS10180	COG4166	transmembrane transport
A16_RS10195	COG0406	alpha-ribazole phosphatase activity
A16_RS10205	COG5337	Spore coat protein CotH
A16_RS10210	COG1051	belongs to the nudix hydrolase family
A16_RS10215	COG0586	Pfam SNARE associated Golgi protein
A16_RS10220	COG2244	polysaccharide biosynthetic process
A16_RS10230	COG0701	Predicted permease
A16_RS10235	COG3689	TIGRFAM TIGR03943 family protein
A16_RS10240	COG1607	acyl-coa hydrolase
A16_RS10245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16_RS10260	COG0702	epimerase
A16_RS10265	COG2839	Protein conserved in bacteria
A16_RS10270	COG1253	flavin adenine dinucleotide binding
A16_RS10285	COG1114	Component of the transport system for branched-chain amino acids
A16_RS10290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16_RS10310	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16_RS10320	COG1876	peptidase activity
A16_RS10330	COG0154	amidase activity
A16_RS10335	COG2211	Major facilitator Superfamily
A16_RS10355	COG0561	phosphatase activity
A16_RS10365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A16_RS10370	COG4106	trans-aconitate 2-methyltransferase activity
A16_RS10385	COG1819	glycosyl
A16_RS10390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_RS10395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_RS10420	COG0456	acetyltransferase
A16_RS10470	COG3874	Sporulation protein YtfJ
A16_RS10495	COG2226	methyltransferase
A16_RS10515	COG1082	Xylose isomerase domain protein TIM barrel
A16_RS10520	COG0346	lactoylglutathione lyase activity
A16_RS10530	COG0604	alcohol dehydrogenase
A16_RS10560	COG0386	Belongs to the glutathione peroxidase family
A16_RS10565	COG1305	Transglutaminase-like
A16_RS10570	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
A16_RS10575	COG0714	Associated with various cellular activities
A16_RS10590	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A16_RS10595	COG1140	nitrate reductase beta subunit
A16_RS10600	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A16_RS10605	COG2181	nitrate reductase activity
A16_RS10625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A16_RS10630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A16_RS10635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16_RS10640	COG0303	'Molybdopterin
A16_RS10645	COG0314	molybdopterin synthase activity
A16_RS10655	COG2223	nitrite transmembrane transporter activity
A16_RS10670	COG1648	precorrin-2 dehydrogenase activity
A16_RS10680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A16_RS10680	COG1587	Uroporphyrinogen-III synthase
A16_RS10685	COG2146	nitrite reductase [NAD(P)H] activity
A16_RS10690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A16_RS10695	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A16_RS10730	COG2359	stage V sporulation protein S
A16_RS10745	COG5632	N-Acetylmuramoyl-L-alanine amidase
A16_RS10760	COG1418	mRNA catabolic process
A16_RS10765	COG0488	(ABC) transporter
A16_RS10780	COG0629	single-stranded DNA binding
A16_RS10795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A16_RS10800	COG1413	lyase activity
A16_RS10815	COG2136	Putative SAM-dependent methyltransferase
A16_RS10815	COG2521	methyltransferase
A16_RS10820	COG0018	arginyl-trna synthetase
A16_RS10845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A16_RS10860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A16_RS10865	COG0017	Asparaginyl-tRNA synthetase
A16_RS10980	COG1929	Belongs to the glycerate kinase type-1 family
A16_RS10985	COG0471	metal ion transport
A16_RS10990	COG0745	RESPONSE REGULATOR receiver
A16_RS10995	COG3850	Histidine kinase
A16_RS10995	COG5002	protein histidine kinase activity
A16_RS11010	COG0733	neurotransmitter:sodium symporter activity
A16_RS11035	COG2610	gluconate transmembrane transporter activity
A16_RS11040	COG1454	alcohol dehydrogenase
A16_RS11045	COG1794	racemase activity, acting on amino acids and derivatives
A16_RS11055	COG0456	acetyltransferase
A16_RS11070	COG1131	(ABC) transporter
A16_RS11075	COG4473	ABC transporter
A16_RS11105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16_RS11120	COG0768	penicillin binding
A16_RS11125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A16_RS11130	COG0204	Acyl-transferase
A16_RS11135	COG1272	protein, Hemolysin III
A16_RS11145	COG0805	protein transport
A16_RS11155	COG1307	EDD domain protein, DegV family
A16_RS11160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A16_RS11165	COG1999	signal sequence binding
A16_RS11170	COG0071	Belongs to the small heat shock protein (HSP20) family
A16_RS11175	COG0367	asparagine synthase
A16_RS11195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_RS11200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16_RS11235	COG0668	transmembrane transport
A16_RS11240	COG4585	Histidine kinase
A16_RS11240	COG2203	Gaf domain
A16_RS11245	COG2197	response regulator
A16_RS11255	COG1737	Transcriptional regulator
A16_RS11260	COG1064	alcohol dehydrogenase
A16_RS11290	COG1070	Carbohydrate kinase
A16_RS11295	COG1070	Carbohydrate kinase
A16_RS11325	COG1125	glycine betaine transport
A16_RS11325	COG0517	IMP dehydrogenase activity
A16_RS11330	COG1174	glycine betaine transport
A16_RS11365	COG1253	flavin adenine dinucleotide binding
A16_RS11370	COG1012	belongs to the aldehyde dehydrogenase family
A16_RS11375	COG5506	Protein of unknown function (DUF1694)
A16_RS11390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A16_RS11395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A16_RS11400	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A16_RS11405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A16_RS11410	COG0456	acetyltransferase
A16_RS11415	COG3829	transcription factor binding
A16_RS11420	COG1509	lysine 2,3-aminomutase activity
A16_RS11460	COG4326	sporulation control protein
A16_RS11465	COG0671	phosphoesterase, PA-phosphatase related
A16_RS11470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A16_RS11475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16_RS11505	COG1715	Restriction endonuclease
A16_RS11505	COG1787	Restriction endonuclease
A16_RS11600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A16_RS11640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16_RS11640	COG4499	WXG100 protein secretion system (Wss), protein YukC
A16_RS11650	COG4841	protein insertion into membrane
A16_RS11655	COG0372	Belongs to the citrate synthase family
A16_RS11660	COG2079	MmgE PrpD family protein
A16_RS11665	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A16_RS11670	COG1960	acyl-CoA dehydrogenase activity
A16_RS11675	COG2084	Dehydrogenase
A16_RS11685	COG1280	lysine exporter protein (LysE YggA)
A16_RS11690	COG1024	Enoyl-CoA hydratase
A16_RS11705	COG0420	3'-5' exonuclease activity
A16_RS11710	COG0419	ATPase involved in DNA repair
A16_RS11740	COG2223	nitrite transmembrane transporter activity
A16_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS11750	COG1169	isochorismate synthase
A16_RS11755	COG1021	2,3-dihydroxybenzoate-AMP ligase
A16_RS11760	COG1535	isochorismatase
A16_RS11760	COG3433	isochorismatase activity
A16_RS11765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A16_RS11770	COG3251	PFAM MbtH domain protein
A16_RS11775	COG2814	Major facilitator Superfamily
A16_RS11790	COG0776	regulation of translation
A16_RS11800	COG2318	DinB family
A16_RS11810	COG1115	amino acid carrier protein
A16_RS11830	COG2329	Antibiotic biosynthesis monooxygenase
A16_RS11835	COG1187	pseudouridine synthase activity
A16_RS11840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A16_RS11855	COG0596	Alpha beta hydrolase
A16_RS11860	COG2814	Major facilitator Superfamily
A16_RS11880	COG2226	methyltransferase
A16_RS11925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_RS11960	COG1247	-acetyltransferase
A16_RS11990	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A16_RS12000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_RS12010	COG1278	Cold shock
A16_RS12025	COG0010	Belongs to the arginase family
A16_RS12030	COG0561	phosphatase activity
A16_RS12075	COG0583	DNA-binding transcription factor activity
A16_RS12080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A16_RS12095	COG0583	DNA-binding transcription factor activity
A16_RS12100	COG2258	MOSC domain
A16_RS12115	COG1132	(ABC) transporter
A16_RS12120	COG1132	(ABC) transporter
A16_RS12140	COG1396	sequence-specific DNA binding
A16_RS12165	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A16_RS12170	COG1595	DNA-templated transcription, initiation
A16_RS12220	COG2971	BadF BadG BcrA BcrD
A16_RS12225	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A16_RS12230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A16_RS12250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_RS12280	COG1309	transcriptional regulator
A16_RS12295	COG1136	(ABC) transporter
A16_RS12295	COG0577	efflux transmembrane transporter activity
A16_RS12300	COG3615	Tellurite resistance protein tehB
A16_RS12300	COG0500	methyltransferase
A16_RS12310	COG2226	methyltransferase
A16_RS12315	COG3961	Belongs to the TPP enzyme family
A16_RS12320	COG1846	Transcriptional regulator
A16_RS12360	COG2195	Cleaves the N-terminal amino acid of tripeptides
A16_RS12375	COG1595	DNA-templated transcription, initiation
A16_RS12385	COG0768	penicillin binding
A16_RS12395	COG2367	Beta-lactamase
A16_RS12400	COG0671	phosphoesterase, PA-phosphatase related
A16_RS12405	COG1609	Transcriptional regulator
A16_RS12410	COG2814	Major facilitator Superfamily
A16_RS12415	COG0673	inositol 2-dehydrogenase activity
A16_RS12425	COG1012	belongs to the aldehyde dehydrogenase family
A16_RS12440	COG0191	fructose-bisphosphate aldolase activity
A16_RS12445	COG3718	enzyme involved in inositol metabolism
A16_RS12460	COG0737	Belongs to the 5'-nucleotidase family
A16_RS12470	COG0737	Belongs to the 5'-nucleotidase family
A16_RS12480	COG0457	Tetratricopeptide repeat
A16_RS12485	COG1476	TRANSCRIPTIONal
A16_RS12500	COG1876	peptidase activity
A16_RS12520	COG1309	transcriptional regulator
A16_RS12525	COG0488	(ABC) transporter
A16_RS12540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_RS12550	COG1252	NADH dehydrogenase
A16_RS12555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_RS12570	COG1131	(ABC) transporter
A16_RS12580	COG1309	transcriptional regulator
A16_RS12595	COG1960	acyl-CoA dehydrogenase activity
A16_RS12600	COG0439	Biotin carboxylase
A16_RS12605	COG0511	ligase activity, forming carbon-carbon bonds
A16_RS12610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A16_RS12615	COG1024	Enoyl-CoA hydratase
A16_RS12620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A16_RS12625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A16_RS12635	COG1247	-acetyltransferase
A16_RS12640	COG0572	uridine kinase
A16_RS12650	COG2318	DinB family
A16_RS12655	COG1686	Belongs to the peptidase S11 family
A16_RS12680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A16_RS12720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A16_RS12720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A16_RS12745	COG2814	Major facilitator Superfamily
A16_RS12765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A16_RS12785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_RS12800	COG1063	alcohol dehydrogenase
A16_RS12815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A16_RS12820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A16_RS12835	COG3773	Cell wall hydrolase
A16_RS12845	COG0745	RESPONSE REGULATOR receiver
A16_RS12875	COG1136	(ABC) transporter
A16_RS12900	COG0460	homoserine dehydrogenase
A16_RS12905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_RS12915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A16_RS12990	COG2124	cytochrome p450
A16_RS13025	COG0561	phosphatase activity
A16_RS13035	COG5002	protein histidine kinase activity
A16_RS13040	COG0768	penicillin binding
A16_RS13045	COG1819	glycosyl
A16_RS13050	COG1794	racemase activity, acting on amino acids and derivatives
A16_RS13060	COG1122	ATPase activity
A16_RS13070	COG2205	protein histidine kinase activity
A16_RS13080	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A16_RS13085	COG0604	alcohol dehydrogenase
A16_RS13090	COG0768	penicillin binding
A16_RS13100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16_RS13135	COG0693	protein deglycase activity
A16_RS13165	COG2814	Major facilitator Superfamily
A16_RS13180	COG0584	glycerophosphoryl diester phosphodiesterase
A16_RS13200	COG0697	spore germination
A16_RS13225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16_RS13235	COG2223	nitrite transmembrane transporter activity
A16_RS13250	COG2816	NAD+ diphosphatase activity
A16_RS13255	COG0592	DNA-directed DNA polymerase activity
A16_RS13260	COG1051	belongs to the nudix hydrolase family
A16_RS13295	COG3878	Protein conserved in bacteria
A16_RS13325	COG4667	esterase of the alpha-beta hydrolase superfamily
A16_RS13350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A16_RS13365	COG0322	excinuclease ABC activity
A16_RS13430	COG1011	Hydrolase
A16_RS13450	COG0076	glutamate decarboxylase activity
A16_RS13465	COG1523	belongs to the glycosyl hydrolase 13 family
A16_RS13470	COG3227	Zinc metalloprotease (Elastase)
A16_RS13490	COG0201	protein transport
A16_RS13500	COG0697	spore germination
A16_RS13505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_RS13535	COG4129	membrane
A16_RS13540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_RS13555	COG2959	enzyme of heme biosynthesis
A16_RS13575	COG3483	tryptophan 2,3-dioxygenase activity
A16_RS13580	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A16_RS13585	COG3844	kynureninase activity
A16_RS13590	COG1309	transcriptional regulator
A16_RS13620	COG3284	Transcriptional regulator
A16_RS13640	COG1349	DNA-binding transcription factor activity
A16_RS13660	COG1959	2 iron, 2 sulfur cluster binding
A16_RS13675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A16_RS13680	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16_RS13685	COG0022	dehydrogenase e1 component
A16_RS13690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A16_RS13700	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS13705	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A16_RS13705	COG0456	acetyltransferase
A16_RS13740	COG4176	ABC-type proline glycine betaine transport system permease component
A16_RS13745	COG0517	IMP dehydrogenase activity
A16_RS13745	COG4175	Glycine betaine
A16_RS13770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A16_RS13775	COG2153	protein acetylation
A16_RS13780	COG3397	chitin binding
A16_RS13795	COG2205	protein histidine kinase activity
A16_RS13825	COG2333	competence protein COMEC
A16_RS13825	COG0658	competence protein
A16_RS13875	COG3973	AAA domain
A16_RS13890	COG2105	PFAM AIG2 family protein
A16_RS13895	COG0514	ATP-dependent DNA helicase (RecQ)
A16_RS13925	COG4637	Psort location Cytoplasmic, score
A16_RS13950	COG3397	chitin binding
A16_RS13960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A16_RS13965	COG1115	amino acid carrier protein
A16_RS13970	COG1012	belongs to the aldehyde dehydrogenase family
A16_RS13975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A16_RS13985	COG3938	Belongs to the proline racemase family
A16_RS13990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16_RS14030	COG0586	Pfam SNARE associated Golgi protein
A16_RS14045	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A16_RS14050	COG0519	Catalyzes the synthesis of GMP from XMP
A16_RS14055	COG4166	transmembrane transport
A16_RS14065	COG4948	Mandelate Racemase Muconate Lactonizing
A16_RS14105	COG2936	dipeptidyl-peptidase activity
A16_RS14110	COG5002	protein histidine kinase activity
A16_RS14115	COG0745	RESPONSE REGULATOR receiver
A16_RS14155	COG1307	EDD domain protein, DegV family
A16_RS14175	COG2814	Major facilitator Superfamily
A16_RS14185	COG1664	Polymer-forming cytoskeletal
A16_RS14190	COG0789	Transcriptional regulator
A16_RS14195	COG4533	DNA binding
A16_RS14200	COG2814	Major facilitator Superfamily
A16_RS14200	COG0477	Major facilitator Superfamily
A16_RS14220	COG2261	transglycosylase associated protein
A16_RS14235	COG2226	methyltransferase
A16_RS14270	COG0436	Aminotransferase
A16_RS14275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A16_RS14280	COG5146	pantothenate kinase activity
A16_RS14305	COG1131	(ABC) transporter
A16_RS14355	COG0628	permease
A16_RS14370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A16_RS14375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16_RS14380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A16_RS14385	COG1116	anion transmembrane transporter activity
A16_RS14405	COG2816	NAD+ diphosphatase activity
A16_RS14425	COG2746	aminoglycoside 3-N-acetyltransferase activity
A16_RS14450	COG0697	spore germination
A16_RS14455	COG2318	DinB family
A16_RS14475	COG4912	Dna alkylation repair
A16_RS14495	COG0861	Integral membrane protein TerC family
A16_RS14500	COG1368	sulfuric ester hydrolase activity
A16_RS14515	COG1033	growth of symbiont in host cell
A16_RS14515	COG2409	Drug exporters of the RND superfamily
A16_RS14520	COG1033	growth of symbiont in host cell
A16_RS14520	COG2409	Drug exporters of the RND superfamily
A16_RS14525	COG1033	growth of symbiont in host cell
A16_RS14525	COG2409	Drug exporters of the RND superfamily
A16_RS14530	COG1309	transcriptional regulator
A16_RS14545	COG0287	Prephenate dehydrogenase
A16_RS14550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A16_RS14555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A16_RS14560	COG1605	Chorismate mutase
A16_RS14560	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A16_RS14595	COG1388	LysM domain
A16_RS14595	COG3584	3D domain protein
A16_RS14605	COG1595	DNA-templated transcription, initiation
A16_RS14630	COG1879	ABC-type sugar transport system periplasmic component
A16_RS14640	COG1172	Belongs to the binding-protein-dependent transport system permease family
A16_RS14650	COG2390	Transcriptional regulator
A16_RS14685	COG2329	Antibiotic biosynthesis monooxygenase
A16_RS14705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_RS14715	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A16_RS14720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16_RS14725	COG4187	Peptidase family M20/M25/M40
A16_RS14730	COG1414	Transcriptional regulator
A16_RS14735	COG0833	amino acid
A16_RS14740	COG1690	Belongs to the RtcB family
A16_RS14745	COG3239	Fatty acid desaturase
A16_RS14750	COG1785	Belongs to the alkaline phosphatase family
A16_RS14760	COG3655	Transcriptional regulator
A16_RS14775	COG4377	Putative membrane peptidase family (DUF2324)
A16_RS14795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_RS14800	COG0346	lactoylglutathione lyase activity
A16_RS14820	COG0714	Associated with various cellular activities
A16_RS14870	COG0463	Glycosyl transferase, family 2
A16_RS14880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A16_RS14885	COG0753	catalase activity
A16_RS14895	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A16_RS14930	COG0778	Nitroreductase
A16_RS14935	COG1846	Transcriptional regulator
A16_RS14970	COG1725	Transcriptional regulator
A16_RS14980	COG0577	efflux transmembrane transporter activity
A16_RS14980	COG1136	(ABC) transporter
A16_RS15005	COG2207	Transcriptional regulator
A16_RS15010	COG0456	acetyltransferase
A16_RS15050	COG0642	Histidine kinase
A16_RS15055	COG0745	RESPONSE REGULATOR receiver
A16_RS15060	COG0596	Alpha beta hydrolase
A16_RS15090	COG0730	response to heat
A16_RS15110	COG4335	DNA alkylation repair
A16_RS15150	COG0768	penicillin binding
A16_RS15160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A16_RS15200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A16_RS15205	COG1414	Transcriptional regulator
A16_RS15220	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16_RS15225	COG0640	Transcriptional regulator
A16_RS15235	COG1960	acyl-CoA dehydrogenase activity
A16_RS15255	COG3314	Sporulation integral membrane protein YlbJ
A16_RS15270	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A16_RS15285	COG3848	Pyruvate phosphate dikinase
A16_RS15285	COG0574	Belongs to the PEP-utilizing enzyme family
A16_RS15290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_RS15305	COG5577	PFAM Coat F domain
A16_RS15310	COG3403	YqcI/YcgG family
A16_RS15315	COG1280	lysine exporter protein (LysE YggA)
A16_RS15350	COG1063	alcohol dehydrogenase
A16_RS15365	COG1027	Aspartate ammonia-lyase
A16_RS15370	COG0252	asparaginase activity
A16_RS15375	COG1396	sequence-specific DNA binding
A16_RS15385	COG0322	excinuclease ABC activity
A16_RS15390	COG0531	amino acid
A16_RS15395	COG1114	Component of the transport system for branched-chain amino acids
A16_RS15400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16_RS15410	COG0281	malic enzyme
A16_RS15430	COG0531	amino acid
A16_RS15435	COG0697	spore germination
A16_RS15450	COG2066	Belongs to the glutaminase family
A16_RS15480	COG0737	Belongs to the 5'-nucleotidase family
A16_RS15485	COG0753	catalase activity
A16_RS15490	COG2267	carboxylic ester hydrolase activity
A16_RS15495	COG1335	isochorismatase
A16_RS15520	COG0583	DNA-binding transcription factor activity
A16_RS15565	COG0415	Belongs to the DNA photolyase family
A16_RS15570	COG0288	reversible hydration of carbon dioxide
A16_RS15580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A16_RS15585	COG5609	conserved protein (DUF2294)
A16_RS15595	COG1575	Belongs to the MenA family. Type 1 subfamily
A16_RS15600	COG2267	carboxylic ester hydrolase activity
A16_RS15605	COG0803	Belongs to the bacterial solute-binding protein 9 family
A16_RS15610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A16_RS15615	COG1121	(ABC) transporter
A16_RS15645	COG0798	PFAM Bile acid sodium symporter
A16_RS15650	COG0346	lactoylglutathione lyase activity
A16_RS15655	COG0640	Transcriptional regulator
A16_RS15670	COG0443	Heat shock 70 kDa protein
A16_RS15685	COG1522	sequence-specific DNA binding
A16_RS15700	COG0346	lactoylglutathione lyase activity
A16_RS15725	COG2169	Transcriptional regulator
A16_RS15770	COG2814	Major facilitator Superfamily
A16_RS15795	COG0745	RESPONSE REGULATOR receiver
A16_RS15800	COG3850	Histidine kinase
A16_RS15800	COG5002	protein histidine kinase activity
A16_RS15830	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A16_RS15855	COG1476	TRANSCRIPTIONal
A16_RS15870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_RS15875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A16_RS15885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16_RS15890	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A16_RS15905	COG1136	(ABC) transporter
A16_RS15910	COG0577	efflux transmembrane transporter activity
A16_RS15930	COG5002	protein histidine kinase activity
A16_RS15930	COG3850	Histidine kinase
A16_RS15940	COG2364	Membrane
A16_RS15945	COG1846	Transcriptional regulator
A16_RS15955	COG2808	Putative FMN-binding domain
A16_RS15960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_RS15965	COG2271	Major facilitator Superfamily
A16_RS15970	COG1556	Lactate utilization protein
A16_RS15975	COG1139	Iron-sulfur cluster binding protein
A16_RS15985	COG0583	DNA-binding transcription factor activity
A16_RS15995	COG1619	proteins homologs of microcin C7 resistance protein MccF
A16_RS16025	COG0673	inositol 2-dehydrogenase activity
A16_RS16030	COG0561	phosphatase activity
A16_RS16040	COG1609	Transcriptional regulator
A16_RS16045	COG0457	Tetratricopeptide repeat
A16_RS16065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A16_RS16095	COG0534	Mate efflux family protein
A16_RS16110	COG2814	Major facilitator Superfamily
A16_RS16115	COG1309	transcriptional regulator
A16_RS16130	COG0814	amino acid
A16_RS16135	COG1760	l-serine dehydratase
A16_RS16140	COG1760	l-serine dehydratase
A16_RS16150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A16_RS16155	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A16_RS16165	COG1335	isochorismatase
A16_RS16170	COG1522	sequence-specific DNA binding
A16_RS16175	COG0531	amino acid
A16_RS16190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A16_RS16210	COG1595	DNA-templated transcription, initiation
A16_RS16225	COG0662	Cupin 2, conserved barrel domain protein
A16_RS16235	COG2207	Transcriptional regulator
A16_RS16235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_RS16290	COG0477	Major facilitator Superfamily
A16_RS16300	COG1846	Transcriptional regulator
A16_RS16305	COG2814	Major facilitator Superfamily
A16_RS16320	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A16_RS16325	COG1131	(ABC) transporter
A16_RS16345	COG2076	Multidrug Resistance protein
A16_RS16350	COG1309	transcriptional regulator
A16_RS16365	COG2031	fatty acid transporter
A16_RS16375	COG2249	NAD(P)H dehydrogenase (quinone) activity
A16_RS16405	COG1122	ATPase activity
A16_RS16410	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A16_RS16425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A16_RS16430	COG1288	antiporter activity
A16_RS16435	COG2356	endonuclease I
A16_RS16450	COG3620	sequence-specific DNA binding
A16_RS16455	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A16_RS16460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A16_RS16465	COG0124	histidyl-tRNA synthetase
A16_RS16480	COG1733	regulation of RNA biosynthetic process
A16_RS16485	COG0778	Nitroreductase
A16_RS16505	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS16515	COG1131	(ABC) transporter
A16_RS16540	COG1011	Hydrolase
A16_RS16550	COG2365	Tyrosine phosphatase family
A16_RS16575	COG0346	lactoylglutathione lyase activity
A16_RS16580	COG1940	carbohydrate kinase activity
A16_RS16585	COG0738	Major facilitator superfamily
A16_RS16590	COG0110	maltose O-acetyltransferase activity
A16_RS16605	COG0577	efflux transmembrane transporter activity
A16_RS16605	COG1136	(ABC) transporter
A16_RS16615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A16_RS16620	COG0628	permease
A16_RS16650	COG0477	Major facilitator Superfamily
A16_RS16680	COG1253	flavin adenine dinucleotide binding
A16_RS16685	COG0789	Transcriptional regulator
A16_RS16690	COG0697	spore germination
A16_RS16695	COG1357	PFAM Pentapeptide repeats (8 copies)
A16_RS16700	COG3813	Protein conserved in bacteria
A16_RS16705	COG2706	6-phosphogluconolactonase activity
A16_RS16710	COG1070	Carbohydrate kinase
A16_RS16720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A16_RS16725	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A16_RS16735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A16_RS16740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A16_RS16745	COG0604	alcohol dehydrogenase
A16_RS16750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A16_RS16760	COG0604	alcohol dehydrogenase
A16_RS16760	COG3321	synthase
A16_RS16770	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS16795	COG0656	L-ascorbic acid biosynthetic process
A16_RS16800	COG2814	Major facilitator Superfamily
A16_RS16815	COG0346	lactoylglutathione lyase activity
A16_RS16820	COG0814	amino acid
A16_RS16845	COG1393	Belongs to the ArsC family
A16_RS16855	COG1733	regulation of RNA biosynthetic process
A16_RS16860	COG2188	Transcriptional regulator
A16_RS16870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A16_RS16875	COG1733	regulation of RNA biosynthetic process
A16_RS16880	COG1733	regulation of RNA biosynthetic process
A16_RS16895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_RS16915	COG0384	phenazine biosynthesis protein PhzF
A16_RS16925	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS16935	COG0318	PFAM AMP-dependent synthetase and ligase
A16_RS16945	COG1733	regulation of RNA biosynthetic process
A16_RS16980	COG1191	sigma factor activity
A16_RS16995	COG1309	transcriptional regulator
A16_RS17015	COG3152	Membrane
A16_RS17040	COG1151	hydroxylamine reductase activity
A16_RS17050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_RS17055	COG3757	hydrolase, family 25
A16_RS17055	COG3409	Peptidoglycan-binding domain 1 protein
A16_RS17090	COG2072	flavoprotein involved in K transport
A16_RS17130	COG1113	amino acid transport
A16_RS17135	COG2814	Major facilitator Superfamily
A16_RS17170	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A16_RS17175	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A16_RS17195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_RS17205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_RS17210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_RS17215	COG3739	integral membrane protein
A16_RS17220	COG0384	phenazine biosynthesis protein PhzF
A16_RS17250	COG0583	DNA-binding transcription factor activity
A16_RS17270	COG1193	negative regulation of DNA recombination
A16_RS17285	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A16_RS17295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16_RS17325	COG0584	glycerophosphoryl diester phosphodiesterase
A16_RS17350	COG0640	Transcriptional regulator
A16_RS17355	COG0604	alcohol dehydrogenase
A16_RS17375	COG2808	Putative FMN-binding domain
A16_RS17380	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A16_RS17390	COG0385	Bile acid
A16_RS17395	COG0277	FAD linked oxidase domain protein
A16_RS17430	COG1216	Glycosyl transferase, family 2
A16_RS17435	COG1024	Enoyl-CoA hydratase
A16_RS17445	COG1285	pathogenesis
A16_RS17455	COG2514	catechol 2,3-dioxygenase activity
A16_RS17460	COG2720	vancomycin resistance protein
A16_RS17500	COG0716	FMN binding
A16_RS17530	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS17540	COG0165	Argininosuccinate lyase
A16_RS17555	COG4145	pantothenate transmembrane transporter activity
A16_RS17565	COG1012	belongs to the aldehyde dehydrogenase family
A16_RS17570	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS17580	COG1657	PFAM Prenyltransferase squalene oxidase
A16_RS17585	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A16_RS17590	COG2962	Rard protein
A16_RS17595	COG3326	Membrane
A16_RS17610	COG0489	protein tyrosine kinase activity
A16_RS17620	COG0314	molybdopterin synthase activity
A16_RS17625	COG0303	'Molybdopterin
A16_RS17630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16_RS17635	COG2116	formate transmembrane transporter activity
A16_RS17645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A16_RS17650	COG5609	conserved protein (DUF2294)
A16_RS17655	COG2427	Protein of unknown function (DUF1641)
A16_RS17670	COG0697	spore germination
A16_RS17710	COG2226	methyltransferase
A16_RS17715	COG4166	transmembrane transport
A16_RS17720	COG4166	transmembrane transport
A16_RS17725	COG4166	transmembrane transport
A16_RS17730	COG1301	dicarboxylic acid transport
A16_RS17735	COG1316	TRANSCRIPTIONal
A16_RS17745	COG1595	DNA-templated transcription, initiation
A16_RS17770	COG1131	(ABC) transporter
A16_RS17780	COG0673	inositol 2-dehydrogenase activity
A16_RS17785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A16_RS17790	COG0187	DNA topoisomerase II activity
A16_RS17800	COG1832	CoA-binding protein
A16_RS17805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A16_RS17810	COG0745	RESPONSE REGULATOR receiver
A16_RS17825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A16_RS17830	COG4841	protein insertion into membrane
A16_RS17835	COG0824	Thioesterase
A16_RS17865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16_RS17875	COG2274	protein secretion by the type I secretion system
A16_RS17910	COG2211	Major facilitator Superfamily
A16_RS17920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A16_RS17935	COG0183	Belongs to the thiolase family
A16_RS17940	COG0318	PFAM AMP-dependent synthetase and ligase
A16_RS17945	COG1268	BioY protein
A16_RS17950	COG0318	PFAM AMP-dependent synthetase and ligase
A16_RS17995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_RS18005	COG5002	protein histidine kinase activity
A16_RS18010	COG0400	carboxylic ester hydrolase activity
A16_RS18015	COG0346	lactoylglutathione lyase activity
A16_RS18020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16_RS18025	COG0069	glutamate synthase activity
A16_RS18030	COG1902	pentaerythritol trinitrate reductase activity
A16_RS18035	COG1329	Transcriptional regulator
A16_RS18040	COG0010	Belongs to the arginase family
A16_RS18065	COG2226	methyltransferase
A16_RS18120	COG4846	Membrane protein involved in cytochrome C biogenesis
A16_RS18125	COG0785	Cytochrome C biogenesis protein
A16_RS18135	COG0583	DNA-binding transcription factor activity
A16_RS18140	COG1380	Effector of murein hydrolase LrgA
A16_RS18145	COG1346	cytolysis
A16_RS18160	COG0730	response to heat
A16_RS18170	COG5632	N-Acetylmuramoyl-L-alanine amidase
A16_RS18170	COG3409	Peptidoglycan-binding domain 1 protein
A16_RS18185	COG1132	(ABC) transporter
A16_RS18190	COG1132	(ABC) transporter
A16_RS18225	COG3639	organic phosphonate transmembrane transporter activity
A16_RS18230	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A16_RS18245	COG0737	Belongs to the 5'-nucleotidase family
A16_RS18255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A16_RS18275	COG1695	Transcriptional regulator
A16_RS18310	COG5632	N-Acetylmuramoyl-L-alanine amidase
A16_RS18310	COG1388	LysM domain
A16_RS18310	COG3409	Peptidoglycan-binding domain 1 protein
A16_RS18315	COG4824	toxin secretion phage lysis holin
A16_RS18475	COG1595	DNA-templated transcription, initiation
A16_RS18520	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A16_RS18600	COG1396	sequence-specific DNA binding
A16_RS18625	COG0174	glutamine synthetase
A16_RS18630	COG0789	Transcriptional regulator
A16_RS18635	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A16_RS18645	COG2860	membrane
A16_RS18650	COG0464	growth
A16_RS18680	COG1388	LysM domain
A16_RS18680	COG3584	3D domain protein
A16_RS18685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A16_RS18685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A16_RS18685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A16_RS18690	COG1105	Belongs to the carbohydrate kinase PfkB family
A16_RS18695	COG1349	DNA-binding transcription factor activity
A16_RS18705	COG2322	membrane
A16_RS18720	COG1113	amino acid transport
A16_RS18730	COG1408	metallophosphoesterase
A16_RS18735	COG2116	formate transmembrane transporter activity
A16_RS18745	COG2217	Heavy metal translocating P-type atpase
A16_RS18750	COG2608	mercury ion transmembrane transporter activity
A16_RS18755	COG1937	Protein conserved in bacteria
A16_RS18765	COG2819	hydrolase of the alpha beta superfamily
A16_RS18770	COG1120	ATPase activity
A16_RS18775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_RS18780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_RS18795	COG0708	Exodeoxyribonuclease III
A16_RS18800	COG2169	Transcriptional regulator
A16_RS18805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A16_RS18810	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A16_RS18820	COG2364	Membrane
A16_RS18835	COG2267	carboxylic ester hydrolase activity
A16_RS18840	COG0346	lactoylglutathione lyase activity
A16_RS18845	COG3300	MHYT domain
A16_RS18845	COG5001	Diguanylate cyclase
A16_RS18865	COG1346	cytolysis
A16_RS18870	COG1380	Effector of murein hydrolase LrgA
A16_RS18875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16_RS18880	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16_RS18880	COG0596	Alpha beta hydrolase
A16_RS18885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A16_RS18900	COG1404	Belongs to the peptidase S8 family
A16_RS18905	COG3773	Cell wall hydrolase
A16_RS18910	COG0562	UDP-galactopyranose mutase
A16_RS18915	COG1368	sulfuric ester hydrolase activity
A16_RS18920	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A16_RS18930	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A16_RS18975	COG4550	Control of competence regulator ComK, YlbF/YmcA
A16_RS18980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A16_RS18985	COG1013	pyruvate-flavodoxin oxidoreductase activity
A16_RS18990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A16_RS18990	COG0674	pyruvate-flavodoxin oxidoreductase activity
A16_RS19000	COG2359	stage V sporulation protein S
A16_RS19005	COG1692	metallophosphoesterase
A16_RS19030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A16_RS19035	COG1426	Protein conserved in bacteria
A16_RS19050	COG0300	oxidoreductase activity
A16_RS19055	COG0612	Peptidase, M16
A16_RS19060	COG0612	Peptidase, M16
A16_RS19070	COG4603	Belongs to the binding-protein-dependent transport system permease family
A16_RS19075	COG4603	Belongs to the binding-protein-dependent transport system permease family
A16_RS19080	COG3845	ABC transporter
A16_RS19085	COG1744	ABC transporter substrate-binding protein PnrA-like
A16_RS19090	COG2188	Transcriptional regulator
A16_RS19095	COG1674	ftsk spoiiie
A16_RS19105	COG0740	serine-type endopeptidase activity
A16_RS19110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A16_RS19125	COG0527	aspartate kinase activity
A16_RS19130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A16_RS19135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A16_RS19140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A16_RS19145	COG1873	PFAM PRC-barrel domain
A16_RS19150	COG0612	Peptidase, M16
A16_RS19155	COG0726	polysaccharide deacetylase
A16_RS19170	COG0196	riboflavin kinase activity
A16_RS19175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A16_RS19185	COG1550	Protein conserved in bacteria
A16_RS19195	COG1358	cellular component organization or biogenesis
A16_RS19200	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A16_RS19205	COG0195	Participates in both transcription termination and antitermination
A16_RS19225	COG0750	zinc metalloprotease
A16_RS19235	COG4589	Belongs to the CDS family
A16_RS19240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A16_RS19250	COG0528	UMP kinase activity
A16_RS19280	COG4974	Belongs to the 'phage' integrase family
A16_RS19290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A16_RS19300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A16_RS19340	COG1837	Belongs to the UPF0109 family
A16_RS19350	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A16_RS19360	COG0552	protein localization to endoplasmic reticulum
A16_RS19375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A16_RS19380	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS19385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A16_RS19400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A16_RS19405	COG1461	Dihydroxyacetone kinase
A16_RS19410	COG1302	Protein conserved in bacteria
A16_RS19425	COG1564	THIamine pyrophosphokinase
A16_RS19430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A16_RS19435	COG1162	GTPase activity
A16_RS19440	COG0515	serine threonine protein kinase
A16_RS19440	COG2815	serine threonine protein kinase
A16_RS19445	COG0631	protein serine/threonine phosphatase activity
A16_RS19455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A16_RS19455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A16_RS19465	COG0242	peptide deformylase activity
A16_RS19470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A16_RS19475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A16_RS19495	COG1561	YicC-like family, N-terminal region
A16_RS19500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A16_RS19510	COG0006	proline dipeptidase activity
A16_RS19525	COG3069	C4-dicarboxylate transmembrane transporter activity
A16_RS19590	COG0564	pseudouridine synthase activity
A16_RS19610	COG3599	regulation of cell shape
A16_RS19615	COG2302	S4 RNA-binding domain
A16_RS19620	COG0762	integral membrane protein
A16_RS19630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A16_RS19635	COG1496	oxidoreductase activity
A16_RS19640	COG1873	PFAM PRC-barrel domain
A16_RS19645	COG1191	sigma factor activity
A16_RS19650	COG1191	sigma factor activity
A16_RS19660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A16_RS19665	COG0849	cell division
A16_RS19670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A16_RS19675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A16_RS19685	COG0772	Belongs to the SEDS family
A16_RS19700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A16_RS19705	COG0768	penicillin binding
A16_RS19710	COG0768	penicillin binding
A16_RS19715	COG4839	cell division protein FtsL
A16_RS19730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A16_RS19745	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A16_RS19750	COG1399	metal-binding, possibly nucleic acid-binding protein
A16_RS19800	COG4824	toxin secretion phage lysis holin
A16_RS19895	COG1802	Transcriptional regulator
A16_RS19895	COG4626	Terminase
A16_RS19920	COG0582	viral genome integration into host DNA
A16_RS19990	COG0756	dUTP diphosphatase activity
A16_RS20000	COG1191	sigma factor activity
A16_RS20025	COG1484	DNA-dependent DNA replication
A16_RS20055	COG1396	sequence-specific DNA binding
A16_RS20065	COG1396	sequence-specific DNA binding
A16_RS20080	COG0582	viral genome integration into host DNA
A16_RS20090	COG3480	Lon protease (S16) C-terminal proteolytic domain
A16_RS20095	COG1752	Esterase of the alpha-beta hydrolase superfamily
A16_RS20100	COG3314	Sporulation integral membrane protein YlbJ
A16_RS20110	COG0742	ribosomal rna small subunit methyltransferase
A16_RS20125	COG3679	Belongs to the UPF0342 family
A16_RS20130	COG0406	alpha-ribazole phosphatase activity
A16_RS20145	COG2340	Cysteine-rich secretory protein family
A16_RS20160	COG3336	cytochrome c oxidase
A16_RS20195	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A16_RS20200	COG0772	Belongs to the SEDS family
A16_RS20210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A16_RS20215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A16_RS20225	COG4896	Protein conserved in bacteria
A16_RS20240	COG1217	gtp-binding protein TYPA
A16_RS20250	COG0483	inositol monophosphate 1-phosphatase activity
A16_RS20270	COG1982	Orn Lys Arg decarboxylase major
A16_RS20315	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16_RS20320	COG0022	dehydrogenase e1 component
A16_RS20325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A16_RS20340	COG0561	phosphatase activity
A16_RS20350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A16_RS20355	COG0569	domain protein
A16_RS20375	COG0583	DNA-binding transcription factor activity
A16_RS20380	COG0517	IMP dehydrogenase activity
A16_RS20390	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A16_RS20400	COG4703	Protein of unknown function (DUF1797)
A16_RS20415	COG2200	EAL domain
A16_RS20420	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS20425	COG1408	metallophosphoesterase
A16_RS20435	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A16_RS20475	COG2814	Major facilitator Superfamily
A16_RS20500	COG3209	COG3209 Rhs family protein
A16_RS20510	COG2205	protein histidine kinase activity
A16_RS20520	COG0436	Aminotransferase
A16_RS20525	COG1609	Transcriptional regulator
A16_RS20530	COG3833	ABC-type maltose transport systems, permease component
A16_RS20535	COG1175	transmembrane transport
A16_RS20540	COG2182	Extracellular solute-binding protein
A16_RS20550	COG0366	Alpha amylase catalytic
A16_RS20555	COG3842	ATPase activity
A16_RS20595	COG0183	Belongs to the thiolase family
A16_RS20635	COG1695	Transcriptional regulator
A16_RS20640	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS20650	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A16_RS20660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A16_RS20665	COG0436	Aminotransferase
A16_RS20685	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A16_RS20705	COG2199	diguanylate cyclase activity
A16_RS20710	COG0778	Nitroreductase
A16_RS20735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16_RS20735	COG2190	(PTS) system
A16_RS20735	COG1263	PTS System
A16_RS20740	COG3711	transcriptional antiterminator
A16_RS20750	COG2188	Transcriptional regulator
A16_RS20760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A16_RS20790	COG1547	Domain of unknown function (DUF309)
A16_RS20795	COG0456	acetyltransferase
A16_RS20805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A16_RS20810	COG4086	secreted protein
A16_RS20815	COG0561	phosphatase activity
A16_RS20820	COG0697	spore germination
A16_RS20835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16_RS20860	COG0733	neurotransmitter:sodium symporter activity
A16_RS20880	COG1686	Belongs to the peptidase S11 family
A16_RS20885	COG1725	Transcriptional regulator
A16_RS20890	COG1131	(ABC) transporter
A16_RS20910	COG1846	Transcriptional regulator
A16_RS20925	COG0598	Magnesium transport protein CorA
A16_RS20950	COG4974	Belongs to the 'phage' integrase family
A16_RS20960	COG0735	belongs to the Fur family
A16_RS20965	COG1300	Membrane
A16_RS20985	COG0667	Aldo Keto reductase
A16_RS20990	COG0656	L-ascorbic acid biosynthetic process
A16_RS20995	COG0456	acetyltransferase
A16_RS20995	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A16_RS21005	COG0737	Belongs to the 5'-nucleotidase family
A16_RS21005	COG1525	nuclease
A16_RS21005	COG4085	toxin activity
A16_RS21015	COG0596	Alpha beta hydrolase
A16_RS21020	COG2056	Na+-H+ antiporter family
A16_RS21025	COG1609	Transcriptional regulator
A16_RS21030	COG0456	acetyltransferase
A16_RS21035	COG1073	alpha beta
A16_RS21050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A16_RS21050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A16_RS21055	COG0307	riboflavin synthase, alpha
A16_RS21080	COG4106	trans-aconitate 2-methyltransferase activity
A16_RS21085	COG1073	alpha beta
A16_RS21085	COG2226	methyltransferase
A16_RS21100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A16_RS21110	COG1757	Na H antiporter
A16_RS21115	COG0737	Belongs to the 5'-nucleotidase family
A16_RS21125	COG1522	sequence-specific DNA binding
A16_RS21145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A16_RS21155	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A16_RS21170	COG0300	oxidoreductase activity
A16_RS21175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_RS21185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16_RS21190	COG1760	l-serine dehydratase
A16_RS21195	COG1760	l-serine dehydratase
A16_RS21215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A16_RS21225	COG2195	Cleaves the N-terminal amino acid of tripeptides
A16_RS21230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_RS21245	COG1376	ErfK ybiS ycfS ynhG family protein
A16_RS21250	COG4129	membrane
A16_RS21255	COG1126	abc transporter atp-binding protein
A16_RS21260	COG0765	amino acid transport
A16_RS21265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16_RS21290	COG0772	Belongs to the SEDS family
A16_RS21300	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16_RS21310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A16_RS21315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A16_RS21330	COG0280	phosphate acetyltransferase
A16_RS21340	COG3290	protein histidine kinase activity
A16_RS21340	COG3829	transcription factor binding
A16_RS21350	COG0584	glycerophosphoryl diester phosphodiesterase
A16_RS21355	COG3093	addiction module antidote protein HigA
A16_RS21365	COG0745	RESPONSE REGULATOR receiver
A16_RS21370	COG0750	zinc metalloprotease
A16_RS21375	COG0497	DNA recombination
A16_RS21385	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A16_RS21395	COG0142	geranyltranstransferase activity
A16_RS21420	COG1302	Protein conserved in bacteria
A16_RS21425	COG0439	Biotin carboxylase
A16_RS21430	COG0511	ligase activity, forming carbon-carbon bonds
A16_RS21475	COG3854	ATPases associated with a variety of cellular activities
A16_RS21500	COG0006	proline dipeptidase activity
A16_RS21515	COG3872	metal-dependent enzyme
A16_RS21525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A16_RS21545	COG0095	Lipoate-protein ligase
A16_RS21550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_RS21555	COG1609	Transcriptional regulator
A16_RS21565	COG2076	Multidrug Resistance protein
A16_RS21570	COG2076	Multidrug Resistance protein
A16_RS21610	COG1131	(ABC) transporter
A16_RS21615	COG1725	Transcriptional regulator
A16_RS21645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A16_RS21700	COG4970	Tfp pilus assembly protein FimT
A16_RS21710	COG1459	type II secretion system
A16_RS21715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A16_RS21765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A16_RS21770	COG0646	methionine synthase
A16_RS21770	COG1410	methionine synthase
A16_RS21775	COG0646	methionine synthase
A16_RS21775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A16_RS21785	COG0626	cystathionine gamma-synthase activity
A16_RS21790	COG0626	cystathionine gamma-synthase activity
A16_RS21815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_RS21825	COG1940	carbohydrate kinase activity
A16_RS21830	COG4483	Protein conserved in bacteria
A16_RS21835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A16_RS21840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A16_RS21845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A16_RS21850	COG0704	Plays a role in the regulation of phosphate uptake
A16_RS21860	COG0581	inorganic phosphate transmembrane transporter activity
A16_RS21865	COG0573	inorganic phosphate transmembrane transporter activity
A16_RS21870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A16_RS21875	COG0768	penicillin binding
A16_RS21880	COG0477	Major facilitator Superfamily
A16_RS21885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A16_RS21910	COG0735	belongs to the Fur family
A16_RS21915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A16_RS21920	COG1121	(ABC) transporter
A16_RS21925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_RS21955	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A16_RS21960	COG2384	SAM-dependent methyltransferase
A16_RS21965	COG2010	Cytochrome c
A16_RS21970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A16_RS21975	COG0358	DNA primase activity
A16_RS21995	COG0517	IMP dehydrogenase activity
A16_RS22010	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A16_RS22015	COG0295	cytidine deaminase activity
A16_RS22020	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A16_RS22030	COG1480	7TM receptor with intracellular HD hydrolase
A16_RS22035	COG1702	phosphate starvation-inducible protein PhoH
A16_RS22055	COG1610	YqeY-like protein
A16_RS22060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A16_RS22065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A16_RS22070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A16_RS22100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A16_RS22105	COG1733	regulation of RNA biosynthetic process
A16_RS22130	COG1466	dna polymerase III delta subunit
A16_RS22140	COG2333	competence protein COMEC
A16_RS22140	COG0658	competence protein
A16_RS22145	COG2131	deaminase
A16_RS22150	COG1596	polysaccharide export
A16_RS22150	COG1555	photosystem II stabilization
A16_RS22155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16_RS22160	COG2226	methyltransferase
A16_RS22165	COG0799	negative regulation of ribosome biogenesis
A16_RS22170	COG1713	HD superfamily hydrolase involved in NAD metabolism
A16_RS22180	COG1534	Rna-binding protein
A16_RS22190	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A16_RS22195	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A16_RS22220	COG1595	DNA-templated transcription, initiation
A16_RS22230	COG0778	Nitroreductase
A16_RS22235	COG2357	RelA SpoT domain protein
A16_RS22245	COG1785	Belongs to the alkaline phosphatase family
A16_RS22255	COG2267	carboxylic ester hydrolase activity
A16_RS22295	COG3186	Phenylalanine-4-hydroxylase
A16_RS22305	COG2514	catechol 2,3-dioxygenase activity
A16_RS22310	COG2514	catechol 2,3-dioxygenase activity
A16_RS22315	COG2259	Doxx family
A16_RS22355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_RS22365	COG1012	belongs to the aldehyde dehydrogenase family
A16_RS22365	COG1454	alcohol dehydrogenase
A16_RS22370	COG0626	cystathionine gamma-synthase activity
A16_RS22375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A16_RS22400	COG0768	penicillin binding
A16_RS22415	COG0826	peptidase U32
A16_RS22420	COG0826	peptidase U32
A16_RS22425	COG4122	O-methyltransferase activity
A16_RS22430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A16_RS22450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A16_RS22460	COG0628	permease
A16_RS22480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A16_RS22490	COG0482	sulfurtransferase activity
A16_RS22495	COG1104	cysteine desulfurase activity
A16_RS22500	COG1959	2 iron, 2 sulfur cluster binding
A16_RS22505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A16_RS22515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A16_RS22540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A16_RS22550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A16_RS22550	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A16_RS22555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A16_RS22560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A16_RS22560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A16_RS22570	COG2244	polysaccharide biosynthetic process
A16_RS22575	COG2323	membrane
A16_RS22585	COG1862	Preprotein translocase
A16_RS22615	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A16_RS22625	COG0697	spore germination
A16_RS22630	COG0697	spore germination
A16_RS22635	COG0640	Transcriptional regulator
A16_RS22660	COG0157	Belongs to the NadC ModD family
A16_RS22665	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A16_RS22670	COG1104	cysteine desulfurase activity
A16_RS22675	COG1827	regulation of RNA biosynthetic process
A16_RS22680	COG2258	MOSC domain
A16_RS22685	COG0077	Prephenate dehydratase
A16_RS22690	COG0577	efflux transmembrane transporter activity
A16_RS22695	COG0577	efflux transmembrane transporter activity
A16_RS22700	COG1136	(ABC) transporter
A16_RS22705	COG5002	protein histidine kinase activity
A16_RS22715	COG0745	RESPONSE REGULATOR receiver
A16_RS22720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A16_RS22725	COG3290	protein histidine kinase activity
A16_RS22735	COG2868	ribosomal protein
A16_RS22745	COG1530	ribonuclease E activity
A16_RS22750	COG1994	Peptidase M50
A16_RS22755	COG0739	heme binding
A16_RS22760	COG2894	cell division
A16_RS22780	COG1077	Cell shape determining protein MreB Mrl
A16_RS22800	COG0285	dihydrofolate synthase activity
A16_RS22805	COG0525	valine-tRNA ligase activity
A16_RS22815	COG1388	LysM domain
A16_RS22825	COG0113	porphobilinogen synthase activity
A16_RS22830	COG1587	Uroporphyrinogen-III synthase
A16_RS22840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A16_RS22850	COG1846	Transcriptional regulator
A16_RS22855	COG1764	response to oxidative stress
A16_RS22870	COG1067	ATP-dependent peptidase activity
A16_RS22870	COG0470	DNA polymerase III
A16_RS22920	COG0622	Phosphoesterase
A16_RS22935	COG5401	PFAM Sporulation and spore germination
A16_RS22955	COG1309	transcriptional regulator
A16_RS22970	COG2197	response regulator
A16_RS22975	COG2233	PERMEase
A16_RS22985	COG0402	S-adenosylhomocysteine deaminase activity
A16_RS22990	COG0402	S-adenosylhomocysteine deaminase activity
A16_RS23000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16_RS23010	COG0444	Belongs to the ABC transporter superfamily
A16_RS23015	COG4608	Belongs to the ABC transporter superfamily
A16_RS23020	COG3275	phosphorelay sensor kinase activity
A16_RS23025	COG3279	Response regulator of the LytR AlgR family
A16_RS23040	COG1983	PspC domain protein
A16_RS23045	COG1396	sequence-specific DNA binding
A16_RS23050	COG0697	spore germination
A16_RS23060	COG1959	2 iron, 2 sulfur cluster binding
A16_RS23065	COG1668	transmembrane transport
A16_RS23070	COG4152	abc transporter atp-binding protein
A16_RS23075	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A16_RS23085	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A16_RS23090	COG1876	peptidase activity
A16_RS23095	COG0824	Thioesterase
A16_RS23100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A16_RS23105	COG1053	succinate dehydrogenase
A16_RS23110	COG2009	succinate dehydrogenase
A16_RS23115	COG1719	4-vinyl reductase, 4VR
A16_RS23125	COG3118	belongs to the thioredoxin family
A16_RS23130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A16_RS23135	COG2086	electron transfer activity
A16_RS23140	COG1024	Enoyl-CoA hydratase
A16_RS23145	COG1309	transcriptional regulator
A16_RS23150	COG0318	PFAM AMP-dependent synthetase and ligase
A16_RS23170	COG2318	DinB family
A16_RS23200	COG1131	(ABC) transporter
A16_RS23205	COG2205	protein histidine kinase activity
A16_RS23210	COG0745	RESPONSE REGULATOR receiver
A16_RS23220	COG4895	conserved protein (DUF2196)
A16_RS23225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A16_RS23240	COG4509	Sortase family
A16_RS23245	COG1120	ATPase activity
A16_RS23260	COG5386	Cell surface protein
A16_RS23270	COG5386	Cell surface protein
A16_RS23275	COG1114	Component of the transport system for branched-chain amino acids
A16_RS23280	COG1187	pseudouridine synthase activity
A16_RS23295	COG1796	DNA polymerase
A16_RS23295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A16_RS23300	COG1286	toxin biosynthetic process
A16_RS23345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A16_RS23355	COG1418	mRNA catabolic process
A16_RS23380	COG2814	Major facilitator Superfamily
A16_RS23385	COG1566	PFAM secretion protein HlyD family protein
A16_RS23390	COG1309	transcriptional regulator
A16_RS23395	COG1363	Peptidase, m42
A16_RS23420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A16_RS23430	COG1484	DNA-dependent DNA replication
A16_RS23435	COG3611	Membrane attachment protein
A16_RS23445	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A16_RS23450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A16_RS23455	COG0237	dephospho-CoA kinase activity
A16_RS23460	COG1971	Probably functions as a manganese efflux pump
A16_RS23470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A16_RS23470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A16_RS23475	COG5002	protein histidine kinase activity
A16_RS23480	COG0745	RESPONSE REGULATOR receiver
A16_RS23500	COG0538	isocitrate dehydrogenase activity
A16_RS23505	COG0372	Belongs to the citrate synthase family
A16_RS23520	COG0628	permease
A16_RS23525	COG3030	protein affecting phage T7 exclusion by the F plasmid
A16_RS23550	COG1725	Transcriptional regulator
A16_RS23555	COG0281	malic enzyme
A16_RS23560	COG0587	DNA-directed DNA polymerase activity
A16_RS23575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A16_RS23595	COG4109	DRTGG domain
A16_RS23610	COG0006	proline dipeptidase activity
A16_RS23645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_RS23650	COG0662	Cupin 2, conserved barrel domain protein
A16_RS23660	COG1476	TRANSCRIPTIONal
A16_RS23675	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS23680	COG0589	response to stress
A16_RS23720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_RS23740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A16_RS23745	COG0827	DNA restriction-modification system
A16_RS23750	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A16_RS23755	COG3874	Sporulation protein YtfJ
A16_RS23770	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A16_RS23780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A16_RS23795	COG1104	cysteine desulfurase activity
A16_RS23805	COG0583	DNA-binding transcription factor activity
A16_RS23810	COG0697	spore germination
A16_RS23820	COG1956	GAF domain-containing protein
A16_RS23825	COG0626	cystathionine gamma-synthase activity
A16_RS23855	COG1595	DNA-templated transcription, initiation
A16_RS23865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A16_RS23870	COG0454	-acetyltransferase
A16_RS23875	COG0517	IMP dehydrogenase activity
A16_RS23880	COG0123	including yeast histone deacetylase and acetoin utilization protein
A16_RS23890	COG0745	RESPONSE REGULATOR receiver
A16_RS23900	COG0666	response to abiotic stimulus
A16_RS23935	COG1609	Transcriptional regulator
A16_RS23945	COG4851	CamS sex pheromone cAM373 precursor
A16_RS23950	COG3118	belongs to the thioredoxin family
A16_RS23960	COG2309	aminopeptidase activity
A16_RS23980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_RS24005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16_RS24010	COG4848	Belongs to the UPF0354 family
A16_RS24015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16_RS24020	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A16_RS24025	COG1363	Peptidase, m42
A16_RS24035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_RS24050	COG0510	thiamine kinase activity
A16_RS24055	COG1523	belongs to the glycosyl hydrolase 13 family
A16_RS24070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A16_RS24075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A16_RS24080	COG1349	DNA-binding transcription factor activity
A16_RS24085	COG1187	pseudouridine synthase activity
A16_RS24090	COG2244	polysaccharide biosynthetic process
A16_RS24095	COG2081	HI0933 family
A16_RS24100	COG2814	Major facilitator Superfamily
A16_RS24110	COG3832	glyoxalase III activity
A16_RS24130	COG1329	Transcriptional regulator
A16_RS24140	COG4975	Glucose uptake
A16_RS24155	COG0314	molybdopterin synthase activity
A16_RS24160	COG1763	Mo-molybdopterin cofactor biosynthetic process
A16_RS24165	COG0303	'Molybdopterin
A16_RS24175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16_RS24200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16_RS24210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A16_RS24255	COG2814	Major facilitator Superfamily
A16_RS24260	COG0475	glutathione-regulated potassium exporter activity
A16_RS24265	COG0490	domain, Protein
A16_RS24270	COG0582	viral genome integration into host DNA
A16_RS24280	COG1136	(ABC) transporter
A16_RS24300	COG1242	4 iron, 4 sulfur cluster binding
A16_RS24305	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A16_RS24310	COG1131	(ABC) transporter
A16_RS24320	COG1794	racemase activity, acting on amino acids and derivatives
A16_RS24340	COG2267	carboxylic ester hydrolase activity
A16_RS24345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A16_RS24350	COG0671	phosphoesterase, PA-phosphatase related
A16_RS24355	COG0438	transferase activity, transferring glycosyl groups
A16_RS24365	COG0521	Mo-molybdopterin cofactor biosynthetic process
A16_RS24420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A16_RS24425	COG5002	protein histidine kinase activity
A16_RS24430	COG4191	Histidine kinase
A16_RS24435	COG2267	carboxylic ester hydrolase activity
A16_RS24455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A16_RS24460	COG1116	anion transmembrane transporter activity
A16_RS24465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16_RS24490	COG0494	nUDIX hydrolase
A16_RS24520	COG0288	reversible hydration of carbon dioxide
A16_RS24525	COG1271	oxidase subunit
A16_RS24530	COG1294	oxidase, subunit
A16_RS24550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_RS24575	COG1842	Phage shock protein A
A16_RS24610	COG5002	protein histidine kinase activity
A16_RS24615	COG0745	RESPONSE REGULATOR receiver
A16_RS24645	COG1597	lipid kinase activity
A16_RS24680	COG0586	Pfam SNARE associated Golgi protein
A16_RS24690	COG0577	efflux transmembrane transporter activity
A16_RS24695	COG1136	(ABC) transporter
A16_RS24700	COG2207	Transcriptional regulator
A16_RS24700	COG3708	Transcriptional regulator
A16_RS24705	COG0745	RESPONSE REGULATOR receiver
A16_RS24710	COG2205	protein histidine kinase activity
A16_RS24715	COG0577	efflux transmembrane transporter activity
A16_RS24725	COG0577	efflux transmembrane transporter activity
A16_RS24730	COG0577	efflux transmembrane transporter activity
A16_RS24735	COG1136	(ABC) transporter
A16_RS24755	COG2188	Transcriptional regulator
A16_RS24775	COG3964	amidohydrolase
A16_RS24805	COG4948	Mandelate Racemase Muconate Lactonizing
A16_RS24815	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A16_RS24825	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A16_RS24830	COG1169	isochorismate synthase
A16_RS24835	COG1575	Belongs to the MenA family. Type 1 subfamily
A16_RS24840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A16_RS24865	COG0058	SHG alpha-glucan phosphorylase activity
A16_RS24870	COG0297	glycogen (starch) synthase activity
A16_RS24875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A16_RS24985	COG0544	peptidyl-prolyl cis-trans isomerase activity
A16_RS25020	COG1285	pathogenesis
A16_RS25025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A16_RS25035	COG0166	Belongs to the GPI family
A16_RS25045	COG2155	Conserved Protein
A16_RS25050	COG1098	S1 RNA binding domain
A16_RS25055	COG0436	Aminotransferase
A16_RS25060	COG1522	sequence-specific DNA binding
A16_RS25065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A16_RS25070	COG2267	carboxylic ester hydrolase activity
A16_RS25080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A16_RS25100	COG5018	Exonuclease
A16_RS25105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A16_RS25125	COG2050	protein possibly involved in aromatic compounds catabolism
A16_RS25135	COG1268	BioY protein
A16_RS25145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A16_RS25150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A16_RS25165	COG3584	3D domain protein
A16_RS25180	COG1252	NADH dehydrogenase
A16_RS25195	COG3708	Transcriptional regulator
A16_RS25210	COG1683	Conserved Protein
A16_RS25230	COG0316	Belongs to the HesB IscA family
A16_RS25245	COG1252	NADH dehydrogenase
A16_RS25260	COG0390	transport system, permease component
A16_RS25265	COG2824	Alkylphosphonate utilization operon protein PhnA
A16_RS25305	COG4837	Protein of unknown function (DUF1462)
A16_RS25310	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A16_RS25320	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A16_RS25325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A16_RS25340	COG2249	NAD(P)H dehydrogenase (quinone) activity
A16_RS25345	COG0647	UMP catabolic process
A16_RS25355	COG2445	Protein of unknown function DUF86
A16_RS25360	COG1494	fructose-1,6-bisphosphatase
A16_RS25380	COG4470	Protein conserved in bacteria
A16_RS25390	COG0789	Transcriptional regulator
A16_RS25395	COG4377	Putative membrane peptidase family (DUF2324)
A16_RS25420	COG0739	heme binding
A16_RS25430	COG3377	Domain of unknown function (DUF1805)
A16_RS25445	COG1695	Transcriptional regulator
A16_RS25460	COG0719	Fe-S assembly protein
A16_RS25465	COG0822	iron-sulfur transferase activity
A16_RS25470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A16_RS25480	COG0396	ATPase activity
A16_RS25485	COG1464	Belongs to the NlpA lipoprotein family
A16_RS25490	COG1464	Belongs to the NlpA lipoprotein family
A16_RS25495	COG2011	ABC-type metal ion transport system permease component
A16_RS25500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A16_RS25515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16_RS25520	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A16_RS25530	COG1393	Belongs to the ArsC family
A16_RS25580	COG0039	L-malate dehydrogenase activity
A16_RS25605	COG1309	transcriptional regulator
A16_RS25610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16_RS25615	COG1960	acyl-CoA dehydrogenase activity
A16_RS25625	COG0183	Belongs to the thiolase family
A16_RS25630	COG1250	3-hydroxyacyl-CoA dehydrogenase
A16_RS25630	COG1024	Enoyl-CoA hydratase
A16_RS25640	COG1686	Belongs to the peptidase S11 family
A16_RS25655	COG0011	TIGRFAM Protein of
A16_RS25660	COG0840	transmembrane signaling receptor activity
A16_RS25680	COG2814	Major facilitator Superfamily
A16_RS25685	COG0531	amino acid
A16_RS25695	COG0706	membrane insertase activity
A16_RS25705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16_RS25740	COG0586	Pfam SNARE associated Golgi protein
A16_RS25750	COG1376	ErfK ybiS ycfS ynhG family protein
A16_RS25755	COG0745	RESPONSE REGULATOR receiver
A16_RS25760	COG5002	protein histidine kinase activity
A16_RS25785	COG2151	metal-sulfur cluster biosynthetic enzyme
A16_RS25790	COG3227	Zinc metalloprotease (Elastase)
A16_RS25795	COG1741	Belongs to the pirin family
A16_RS25810	COG0475	glutathione-regulated potassium exporter activity
A16_RS25815	COG0490	domain, Protein
A16_RS25825	COG1115	amino acid carrier protein
A16_RS25830	COG0783	Belongs to the Dps family
A16_RS25845	COG1611	Belongs to the LOG family
A16_RS25860	COG2311	Membrane
A16_RS25870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_RS25875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_RS25880	COG1115	amino acid carrier protein
A16_RS25885	COG1115	amino acid carrier protein
A16_RS25890	COG2910	NAD(P)H-binding
A16_RS25905	COG0656	L-ascorbic acid biosynthetic process
A16_RS25910	COG2814	Major facilitator Superfamily
A16_RS25915	COG1733	regulation of RNA biosynthetic process
A16_RS25925	COG1252	NADH dehydrogenase
A16_RS25930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A16_RS25935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A16_RS25945	COG3290	protein histidine kinase activity
A16_RS25945	COG0840	transmembrane signaling receptor activity
A16_RS25955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A16_RS25960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A16_RS25975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16_RS26025	COG0557	exoribonuclease II activity
A16_RS26030	COG1647	Serine aminopeptidase, S33
A16_RS26035	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A16_RS26040	COG1346	cytolysis
A16_RS26140	COG4695	Portal protein
A16_RS26165	COG4974	Belongs to the 'phage' integrase family
A16_RS26175	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A16_RS26180	COG0149	triose-phosphate isomerase activity
A16_RS26190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A16_RS26205	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A16_RS26230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16_RS26245	COG2323	membrane
A16_RS26250	COG0740	serine-type endopeptidase activity
A16_RS26255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A16_RS26265	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A16_RS26275	COG1051	belongs to the nudix hydrolase family
A16_RS26285	COG0492	ferredoxin-NADP+ reductase activity
A16_RS26290	COG0457	Tetratricopeptide repeat
A16_RS26295	COG0110	maltose O-acetyltransferase activity
A16_RS26315	COG1950	PFAM Membrane protein of
A16_RS26325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A16_RS26330	COG0556	nucleotide-excision repair
A16_RS26350	COG0789	Transcriptional regulator
A16_RS26375	COG2855	membrane
A16_RS26380	COG0583	DNA-binding transcription factor activity
A16_RS26390	COG0655	NAD(P)H dehydrogenase (quinone) activity
A16_RS26395	COG0488	(ABC) transporter
A16_RS26405	COG1132	(ABC) transporter
A16_RS26410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A16_RS26415	COG3409	Peptidoglycan-binding domain 1 protein
A16_RS26415	COG0793	Belongs to the peptidase S41A family
A16_RS26420	COG2177	Part of the ABC transporter FtsEX involved in
A16_RS26425	COG2884	Cell division ATP-binding protein ftsE
A16_RS26440	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A16_RS26450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A16_RS26455	COG1278	Cold shock
A16_RS26460	COG1040	competence protein
A16_RS26470	COG0791	NLP P60 protein
A16_RS26470	COG1388	LysM domain
A16_RS26475	COG1733	regulation of RNA biosynthetic process
A16_RS26485	COG1307	EDD domain protein, DegV family
A16_RS26490	COG1739	Uncharacterized protein family UPF0029
A16_RS26495	COG1316	TRANSCRIPTIONal
A16_RS26500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A16_RS26505	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A16_RS26510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A16_RS26520	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A16_RS26520	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A16_RS26535	COG3394	polysaccharide catabolic process
A16_RS26540	COG1486	melibiose metabolic process
A16_RS26545	COG1447	Phosphotransferase system cellobiose-specific component IIA
A16_RS26550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A16_RS26560	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A16_RS26565	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A16_RS26570	COG1447	Phosphotransferase system cellobiose-specific component IIA
A16_RS26580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A16_RS26585	COG1301	dicarboxylic acid transport
A16_RS26595	COG0346	lactoylglutathione lyase activity
A16_RS26600	COG1511	domain protein
A16_RS26605	COG0583	DNA-binding transcription factor activity
A16_RS26610	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A16_RS26630	COG1271	oxidase subunit
A16_RS26635	COG1294	oxidase, subunit
A16_RS26640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A16_RS26650	COG1620	l-lactate permease
A16_RS26660	COG2389	metal-binding protein
A16_RS26670	COG1368	sulfuric ester hydrolase activity
A16_RS26685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16_RS26705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A16_RS26710	COG1388	LysM domain
A16_RS26710	COG3584	3D domain protein
A16_RS26735	COG4715	Zinc finger, swim domain protein
A16_RS26740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A16_RS26780	COG0577	efflux transmembrane transporter activity
A16_RS26785	COG1136	(ABC) transporter
A16_RS26820	COG5002	protein histidine kinase activity
A16_RS26825	COG0745	RESPONSE REGULATOR receiver
A16_RS26830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A16_RS26850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A16_RS26855	COG1134	teichoic acid transport
A16_RS26860	COG1682	transport, permease protein
A16_RS26865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A16_RS26910	COG1609	Transcriptional regulator
A16_RS26925	COG0739	heme binding
A16_RS26940	COG3279	Response regulator of the LytR AlgR family
A16_RS26945	COG4555	ABC transporter
A16_RS26950	COG2385	sporulation resulting in formation of a cellular spore
A16_RS26965	COG4836	Membrane
A16_RS26970	COG1007	ATP synthesis coupled electron transport
A16_RS26975	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A16_RS26980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A16_RS26990	COG0839	Belongs to the complex I subunit 6 family
A16_RS27005	COG0649	NAD binding
A16_RS27010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A16_RS27025	COG3300	MHYT domain
A16_RS27025	COG5001	Diguanylate cyclase
A16_RS27075	COG0356	it plays a direct role in the translocation of protons across the membrane
A16_RS27110	COG0698	ribose 5-phosphate isomerase
A16_RS27120	COG2190	(PTS) system
A16_RS27125	COG2259	Doxx family
A16_RS27130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A16_RS27145	COG0009	L-threonylcarbamoyladenylate synthase
A16_RS27160	COG2890	protein-(glutamine-N5) methyltransferase activity
A16_RS27180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A16_RS27185	COG1494	fructose-1,6-bisphosphatase
A16_RS27205	COG4821	SIS domain
A16_RS27215	COG3343	RNA polymerase activity
A16_RS27225	COG1960	acyl-CoA dehydrogenase activity
A16_RS27230	COG1960	acyl-CoA dehydrogenase activity
A16_RS27240	COG0183	Belongs to the thiolase family
A16_RS27245	COG0247	lactate metabolic process
A16_RS27245	COG2181	nitrate reductase activity
A16_RS27250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16_RS27260	COG3300	MHYT domain
A16_RS27260	COG5001	Diguanylate cyclase
A16_RS27275	COG2197	response regulator
A16_RS27280	COG4585	Histidine kinase
A16_RS27285	COG0842	Transport permease protein
A16_RS27290	COG1131	(ABC) transporter
A16_RS27295	COG0024	Methionine aminopeptidase
A16_RS27315	COG2234	aminopeptidase activity
A16_RS27335	COG1595	DNA-templated transcription, initiation
A16_RS27345	COG4506	Protein conserved in bacteria
A16_RS27350	COG1619	proteins homologs of microcin C7 resistance protein MccF
A16_RS27370	COG0010	Belongs to the arginase family
A16_RS27380	COG2814	Major facilitator Superfamily
A16_RS27385	COG0789	Transcriptional regulator
A16_RS27390	COG0584	glycerophosphoryl diester phosphodiesterase
A16_RS27395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16_RS27405	COG1994	Peptidase M50
A16_RS27415	COG1078	dGTPase activity
A16_RS27420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16_RS27425	COG1120	ATPase activity
A16_RS27430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_RS27435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_RS27440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16_RS27460	COG0095	Lipoate-protein ligase
A16_RS27465	COG0280	phosphate acetyltransferase
A16_RS27480	COG3773	Cell wall hydrolase
A16_RS27490	COG2363	Small membrane protein
A16_RS27505	COG2233	PERMEase
A16_RS27510	COG0561	phosphatase activity
A16_RS27515	COG2814	Major facilitator Superfamily
A16_RS27525	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A16_RS27530	COG1131	(ABC) transporter
A16_RS27535	COG2755	lipolytic protein G-D-S-L family
A16_RS27540	COG1609	Transcriptional regulator
A16_RS27550	COG0460	homoserine dehydrogenase
A16_RS27560	COG2873	o-acetylhomoserine
A16_RS27570	COG1011	Hydrolase
A16_RS27575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A16_RS27585	COG2197	response regulator
A16_RS27595	COG0351	phosphomethylpyrimidine kinase
A16_RS27600	COG3706	GGDEF domain
A16_RS27605	COG2879	small protein
A16_RS27610	COG1966	Carbon starvation protein
A16_RS27615	COG3279	Response regulator of the LytR AlgR family
A16_RS27620	COG0477	Major facilitator Superfamily
A16_RS27645	COG0840	transmembrane signaling receptor activity
A16_RS27655	COG1607	acyl-coa hydrolase
A16_RS27670	COG0488	(ABC) transporter
A16_RS27695	COG0463	Glycosyl transferase, family 2
A16_RS27700	COG1309	transcriptional regulator
A16_RS27705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A16_RS27710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A16_RS27710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A16_RS27715	COG0628	permease
A16_RS27730	COG3279	Response regulator of the LytR AlgR family
A16_RS27735	COG3275	phosphorelay sensor kinase activity
A16_RS27740	COG2814	Major facilitator Superfamily
A16_RS27745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A16_RS27750	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A16_RS27755	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A16_RS27775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A16_RS27780	COG1272	protein, Hemolysin III
A16_RS27800	COG0516	GMP reductase activity
A16_RS27805	COG1164	Oligoendopeptidase f
A16_RS27825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A16_RS27830	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A16_RS27835	COG4853	Protein conserved in bacteria
A16_RS27845	COG5002	protein histidine kinase activity
A16_RS27850	COG0745	RESPONSE REGULATOR receiver
A16_RS27880	COG0305	Participates in initiation and elongation during chromosome replication
A16_RS27890	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A16_RS27895	COG4241	membrane
A16_RS27905	COG0629	single-stranded DNA binding
A16_RS27915	COG0012	GTP binding
A16_RS27920	COG4481	Protein conserved in bacteria
A16_RS27925	COG0668	transmembrane transport
A16_RS27935	COG1475	DNA binding
A16_RS27940	COG1192	Involved in chromosome partitioning
A16_RS27965	COG1847	R3H domain protein
A16_RS27970	COG0706	membrane insertase activity
A16_RS27980	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A16_RS28315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A16_RS28420	COG4956	integral membrane protein (PIN domain superfamily)
A16_RS28445	COG1045	serine acetyltransferase
A16_RS28745	COG2610	gluconate transmembrane transporter activity
A16_RS28795	COG1028	Short-chain dehydrogenase reductase Sdr
A16_RS28810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A16_RS29325	COG2376	Dihydroxyacetone kinase