locus-tag	class	description
A16R_RS00010	COG0592	DNA-directed DNA polymerase activity
A16R_RS00015	COG2501	S4 domain
A16R_RS00025	COG0187	DNA topoisomerase II activity
A16R_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A16R_RS00065	COG0517	IMP dehydrogenase activity
A16R_RS00065	COG0516	GMP reductase activity
A16R_RS00070	COG1686	Belongs to the peptidase S11 family
A16R_RS00100	COG1428	Deoxynucleoside kinase
A16R_RS00105	COG1428	Deoxynucleoside kinase
A16R_RS00110	COG1335	isochorismatase
A16R_RS00120	COG0590	tRNA wobble adenosine to inosine editing
A16R_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A16R_RS00185	COG1982	Orn Lys Arg decarboxylase major
A16R_RS00195	COG0470	DNA polymerase III
A16R_RS00200	COG1774	PSP1 C-terminal conserved region
A16R_RS00210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A16R_RS00220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A16R_RS00225	COG2002	toxin-antitoxin pair type II binding
A16R_RS00230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16R_RS00230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16R_RS00235	COG0084	hydrolase, TatD family'
A16R_RS00240	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A16R_RS00255	COG4466	Protein conserved in bacteria
A16R_RS00270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A16R_RS00280	COG0251	oxidation-reduction process
A16R_RS00310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A16R_RS00315	COG2002	toxin-antitoxin pair type II binding
A16R_RS00320	COG2244	polysaccharide biosynthetic process
A16R_RS00325	COG3956	TIGRFAM MazG family protein
A16R_RS00330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A16R_RS00350	COG1098	S1 RNA binding domain
A16R_RS00365	COG2208	phosphoserine phosphatase activity
A16R_RS00370	COG0037	tRNA processing
A16R_RS00375	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A16R_RS00380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A16R_RS00395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A16R_RS00400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A16R_RS00405	COG0512	Glutamine amidotransferase of anthranilate synthase
A16R_RS00410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16R_RS00415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A16R_RS00420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A16R_RS00425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A16R_RS00430	COG1396	sequence-specific DNA binding
A16R_RS00435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A16R_RS00465	COG3880	PFAM UvrB UvrC protein
A16R_RS00475	COG0542	response to heat
A16R_RS00480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A16R_RS00490	COG4956	integral membrane protein (PIN domain superfamily)
A16R_RS00510	COG1045	serine acetyltransferase
A16R_RS00525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A16R_RS00530	COG3688	RNA-binding protein containing a PIN domain
A16R_RS00545	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A16R_RS00550	COG0250	Participates in transcription elongation, termination and antitermination
A16R_RS00555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A16R_RS00575	COG2813	Specifically methylates the guanine in position
A16R_RS00585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A16R_RS00590	COG1358	cellular component organization or biogenesis
A16R_RS00660	COG0255	Belongs to the universal ribosomal protein uL29 family
A16R_RS00720	COG0201	protein transport
A16R_RS00730	COG0024	Methionine aminopeptidase
A16R_RS00740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A16R_RS00775	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A16R_RS00800	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16R_RS00805	COG0489	protein tyrosine kinase activity
A16R_RS00815	COG2194	sulfuric ester hydrolase activity
A16R_RS00820	COG0726	polysaccharide deacetylase
A16R_RS00905	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A16R_RS00910	COG4856	YbbR-like protein
A16R_RS00925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A16R_RS00930	COG0596	Alpha beta hydrolase
A16R_RS00950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A16R_RS00960	COG4946	Tricorn protease homolog
A16R_RS00960	COG1506	peptidase
A16R_RS00960	COG0823	Involved in the tonB-independent uptake of proteins
A16R_RS00995	COG2011	ABC-type metal ion transport system permease component
A16R_RS01000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A16R_RS01005	COG1464	Belongs to the NlpA lipoprotein family
A16R_RS01010	COG0604	alcohol dehydrogenase
A16R_RS01020	COG0277	FAD linked oxidase domain protein
A16R_RS01025	COG2271	Major facilitator Superfamily
A16R_RS01035	COG2814	Major facilitator Superfamily
A16R_RS01050	COG0601	transmembrane transport
A16R_RS01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16R_RS01060	COG0444	Belongs to the ABC transporter superfamily
A16R_RS01065	COG4608	Belongs to the ABC transporter superfamily
A16R_RS01070	COG4166	transmembrane transport
A16R_RS01080	COG2207	Transcriptional regulator
A16R_RS01095	COG4166	transmembrane transport
A16R_RS01100	COG4166	transmembrane transport
A16R_RS01105	COG0656	L-ascorbic acid biosynthetic process
A16R_RS01110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16R_RS01130	COG4149	molybdate abc transporter
A16R_RS01140	COG1910	domain protein
A16R_RS01155	COG0583	DNA-binding transcription factor activity
A16R_RS01160	COG0697	spore germination
A16R_RS01175	COG0204	Acyl-transferase
A16R_RS01190	COG1609	Transcriptional regulator
A16R_RS01200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16R_RS01215	COG0084	hydrolase, TatD family'
A16R_RS01220	COG5298	Protein conserved in bacteria
A16R_RS01245	COG0488	(ABC) transporter
A16R_RS01260	COG0747	negative chemotaxis
A16R_RS01265	COG0601	transmembrane transport
A16R_RS01270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16R_RS01275	COG0444	Belongs to the ABC transporter superfamily
A16R_RS01280	COG4608	Belongs to the ABC transporter superfamily
A16R_RS01305	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A16R_RS01310	COG0179	Fumarylacetoacetate (FAA) hydrolase
A16R_RS01325	COG2814	Major facilitator Superfamily
A16R_RS01335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A16R_RS01345	COG4294	response to UV
A16R_RS01350	COG0705	Rhomboid family
A16R_RS01350	COG0457	Tetratricopeptide repeat
A16R_RS01360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A16R_RS01365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A16R_RS01370	COG0864	Transcriptional regulator
A16R_RS01375	COG2337	Toxic component of a toxin-antitoxin (TA) module
A16R_RS01380	COG2183	response to ionizing radiation
A16R_RS01475	COG0802	atpase or kinase
A16R_RS01480	COG1214	PFAM Peptidase M22, glycoprotease
A16R_RS01485	COG0456	acetyltransferase
A16R_RS01495	COG0488	(ABC) transporter
A16R_RS01510	COG1266	CAAX protease self-immunity
A16R_RS01530	COG2252	PERMEase
A16R_RS01540	COG5002	protein histidine kinase activity
A16R_RS01570	COG2226	methyltransferase
A16R_RS01615	COG1968	undecaprenyl-diphosphatase activity
A16R_RS01660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A16R_RS01665	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A16R_RS01670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A16R_RS01680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A16R_RS01695	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A16R_RS01705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A16R_RS01715	COG0151	Belongs to the GarS family
A16R_RS01745	COG0210	DNA helicase
A16R_RS01755	COG4851	CamS sex pheromone cAM373 precursor
A16R_RS01775	COG1335	isochorismatase
A16R_RS01785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A16R_RS01790	COG2011	ABC-type metal ion transport system permease component
A16R_RS01795	COG1464	Belongs to the NlpA lipoprotein family
A16R_RS01815	COG1846	Transcriptional regulator
A16R_RS01840	COG1597	lipid kinase activity
A16R_RS01845	COG0546	phosphoglycolate phosphatase activity
A16R_RS01850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A16R_RS01860	COG1012	belongs to the aldehyde dehydrogenase family
A16R_RS01865	COG2076	Multidrug Resistance protein
A16R_RS01870	COG2309	aminopeptidase activity
A16R_RS01885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16R_RS01890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A16R_RS01895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A16R_RS01905	COG4807	Protein conserved in bacteria
A16R_RS01930	COG1757	Na H antiporter
A16R_RS01935	COG1473	amidohydrolase
A16R_RS01950	COG0450	alkyl hydroperoxide reductase
A16R_RS01970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16R_RS01975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16R_RS01980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16R_RS02005	COG0166	Belongs to the GPI family
A16R_RS02050	COG5002	protein histidine kinase activity
A16R_RS02070	COG3541	Predicted nucleotidyltransferase
A16R_RS02075	COG2814	Major facilitator Superfamily
A16R_RS02080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16R_RS02080	COG0723	plastoquinol--plastocyanin reductase activity
A16R_RS02090	COG0765	amino acid transport
A16R_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16R_RS02110	COG0840	transmembrane signaling receptor activity
A16R_RS02115	COG0840	transmembrane signaling receptor activity
A16R_RS02120	COG0366	Alpha amylase catalytic
A16R_RS02125	COG2190	(PTS) system
A16R_RS02125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16R_RS02125	COG1263	PTS System
A16R_RS02155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A16R_RS02170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16R_RS02180	COG1116	anion transmembrane transporter activity
A16R_RS02185	COG0488	(ABC) transporter
A16R_RS02230	COG2270	Major facilitator Superfamily
A16R_RS02245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A16R_RS02260	COG2310	stress, protein
A16R_RS02265	COG2310	stress, protein
A16R_RS02270	COG2310	stress, protein
A16R_RS02275	COG0861	Integral membrane protein TerC family
A16R_RS02285	COG3853	Toxic anion resistance protein (TelA)
A16R_RS02300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A16R_RS02310	COG1295	ribonuclease BN
A16R_RS02320	COG2217	Heavy metal translocating P-type atpase
A16R_RS02325	COG0697	spore germination
A16R_RS02345	COG0586	Pfam SNARE associated Golgi protein
A16R_RS02360	COG3871	stress protein (general stress protein 26)
A16R_RS02365	COG0387	Pfam Sodium calcium exchanger
A16R_RS02375	COG0535	radical SAM domain protein
A16R_RS02400	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A16R_RS02405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A16R_RS02410	COG0582	viral genome integration into host DNA
A16R_RS02415	COG1396	sequence-specific DNA binding
A16R_RS02435	COG1396	sequence-specific DNA binding
A16R_RS02470	COG1484	DNA-dependent DNA replication
A16R_RS02575	COG0582	viral genome integration into host DNA
A16R_RS02580	COG0582	viral genome integration into host DNA
A16R_RS02725	COG0101	tRNA pseudouridine synthase activity
A16R_RS02735	COG3829	transcription factor binding
A16R_RS02745	COG0833	amino acid
A16R_RS02750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A16R_RS02790	COG1263	PTS System
A16R_RS02790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16R_RS02795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16R_RS02810	COG0463	Glycosyl transferase, family 2
A16R_RS02825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A16R_RS02825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A16R_RS02845	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A16R_RS02865	COG1228	amidohydrolase
A16R_RS02870	COG1090	epimerase
A16R_RS02900	COG1988	membrane-bound metal-dependent
A16R_RS02905	COG1194	a g-specific adenine glycosylase
A16R_RS02930	COG1132	(ABC) transporter
A16R_RS02935	COG4129	membrane
A16R_RS02940	COG0067	glutamate synthase
A16R_RS02940	COG0069	glutamate synthase activity
A16R_RS02940	COG0070	glutamate synthase
A16R_RS02950	COG4555	ABC transporter
A16R_RS02970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A16R_RS02975	COG0735	belongs to the Fur family
A16R_RS03095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A16R_RS03100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A16R_RS03110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A16R_RS03120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A16R_RS03135	COG2766	serine protein kinase
A16R_RS03160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16R_RS03165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A16R_RS03175	COG1585	Membrane protein implicated in regulation of membrane protease activity
A16R_RS03180	COG2268	Band 7 protein
A16R_RS03190	COG3290	protein histidine kinase activity
A16R_RS03200	COG2851	Citrate transporter
A16R_RS03225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A16R_RS03230	COG3842	ATPase activity
A16R_RS03235	COG1175	transmembrane transport
A16R_RS03240	COG0395	ABC-type sugar transport system, permease component
A16R_RS03250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A16R_RS03255	COG0745	RESPONSE REGULATOR receiver
A16R_RS03260	COG5002	protein histidine kinase activity
A16R_RS03270	COG4990	cell redox homeostasis
A16R_RS03280	COG3290	protein histidine kinase activity
A16R_RS03285	COG4565	transcriptional regulatory protein
A16R_RS03290	COG3493	citrate carrier protein
A16R_RS03295	COG0281	malic enzyme
A16R_RS03310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16R_RS03320	COG5002	protein histidine kinase activity
A16R_RS03325	COG0745	RESPONSE REGULATOR receiver
A16R_RS03335	COG0454	-acetyltransferase
A16R_RS03335	COG0456	acetyltransferase
A16R_RS03340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A16R_RS03345	COG3383	formate dehydrogenase (NAD+) activity
A16R_RS03350	COG2427	Protein of unknown function (DUF1641)
A16R_RS03365	COG0531	amino acid
A16R_RS03375	COG0640	Transcriptional regulator
A16R_RS03380	COG2217	Heavy metal translocating P-type atpase
A16R_RS03385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A16R_RS03400	COG3227	Zinc metalloprotease (Elastase)
A16R_RS03420	COG2720	vancomycin resistance protein
A16R_RS03425	COG1316	TRANSCRIPTIONal
A16R_RS03430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16R_RS03435	COG0346	lactoylglutathione lyase activity
A16R_RS03440	COG1253	flavin adenine dinucleotide binding
A16R_RS03445	COG1027	Aspartate ammonia-lyase
A16R_RS03450	COG1620	l-lactate permease
A16R_RS03465	COG3104	oligopeptide transport
A16R_RS03470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16R_RS03475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16R_RS03480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16R_RS03490	COG2226	methyltransferase
A16R_RS03495	COG0156	8-amino-7-oxononanoate synthase activity
A16R_RS03500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A16R_RS03510	COG4548	von Willebrand factor, type A
A16R_RS03515	COG0714	Associated with various cellular activities
A16R_RS03520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16R_RS03540	COG0531	amino acid
A16R_RS03545	COG2188	Transcriptional regulator
A16R_RS03550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16R_RS03550	COG1263	PTS System
A16R_RS03555	COG0366	Alpha amylase catalytic
A16R_RS03570	COG0697	spore germination
A16R_RS03580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A16R_RS03585	COG1115	amino acid carrier protein
A16R_RS03590	COG1126	abc transporter atp-binding protein
A16R_RS03595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16R_RS03600	COG0765	amino acid transport
A16R_RS03605	COG0765	amino acid transport
A16R_RS03610	COG0833	amino acid
A16R_RS03635	COG2378	regulation of single-species biofilm formation
A16R_RS03640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A16R_RS03645	COG5002	protein histidine kinase activity
A16R_RS03660	COG0659	secondary active sulfate transmembrane transporter activity
A16R_RS03675	COG0747	negative chemotaxis
A16R_RS03685	COG0601	transmembrane transport
A16R_RS03690	COG4608	Belongs to the ABC transporter superfamily
A16R_RS03700	COG2271	Major facilitator Superfamily
A16R_RS03705	COG1846	Transcriptional regulator
A16R_RS03715	COG1609	Transcriptional regulator
A16R_RS03720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A16R_RS03735	COG1172	Belongs to the binding-protein-dependent transport system permease family
A16R_RS03740	COG1879	ABC-type sugar transport system periplasmic component
A16R_RS03765	COG1063	alcohol dehydrogenase
A16R_RS03780	COG3568	Endonuclease Exonuclease Phosphatase
A16R_RS03805	COG1968	undecaprenyl-diphosphatase activity
A16R_RS03810	COG0840	transmembrane signaling receptor activity
A16R_RS03815	COG1388	LysM domain
A16R_RS03815	COG3584	3D domain protein
A16R_RS03820	COG1476	TRANSCRIPTIONal
A16R_RS03835	COG3104	oligopeptide transport
A16R_RS03840	COG1114	Component of the transport system for branched-chain amino acids
A16R_RS03855	COG1113	amino acid transport
A16R_RS03860	COG2252	PERMEase
A16R_RS03885	COG0475	glutathione-regulated potassium exporter activity
A16R_RS03885	COG0569	domain protein
A16R_RS03900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A16R_RS03905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A16R_RS03910	COG0833	amino acid
A16R_RS03915	COG4990	cell redox homeostasis
A16R_RS03930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16R_RS03935	COG0697	spore germination
A16R_RS03940	COG0531	amino acid
A16R_RS03955	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A16R_RS03960	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A16R_RS03965	COG1918	ferrous iron import across plasma membrane
A16R_RS03965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A16R_RS03970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A16R_RS03975	COG0573	inorganic phosphate transmembrane transporter activity
A16R_RS03980	COG0581	inorganic phosphate transmembrane transporter activity
A16R_RS03990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A16R_RS04105	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A16R_RS04130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A16R_RS04135	COG1116	anion transmembrane transporter activity
A16R_RS04140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16R_RS04145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A16R_RS04150	COG0352	thiamine-phosphate diphosphorylase activity
A16R_RS04155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16R_RS04160	COG2104	thiamine diphosphate biosynthetic process
A16R_RS04170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16R_RS04175	COG0351	phosphomethylpyrimidine kinase
A16R_RS04220	COG2205	protein histidine kinase activity
A16R_RS04225	COG2814	Major facilitator Superfamily
A16R_RS04230	COG1846	Transcriptional regulator
A16R_RS04245	COG2252	PERMEase
A16R_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS04265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A16R_RS04270	COG1621	beta-fructofuranosidase activity
A16R_RS04275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16R_RS04275	COG1263	PTS System
A16R_RS04280	COG1609	Transcriptional regulator
A16R_RS04290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16R_RS04295	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A16R_RS04335	COG0778	Nitroreductase
A16R_RS04340	COG2719	SpoVR family
A16R_RS04370	COG0446	pyridine nucleotide-disulphide oxidoreductase
A16R_RS04375	COG1937	Protein conserved in bacteria
A16R_RS04380	COG0425	Belongs to the sulfur carrier protein TusA family
A16R_RS04380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16R_RS04385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16R_RS04385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16R_RS04390	COG0425	Belongs to the sulfur carrier protein TusA family
A16R_RS04395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16R_RS04405	COG2210	Belongs to the sulfur carrier protein TusA family
A16R_RS04410	COG0730	response to heat
A16R_RS04420	COG1316	TRANSCRIPTIONal
A16R_RS04425	COG0604	alcohol dehydrogenase
A16R_RS04430	COG1283	sodium-dependent phosphate transmembrane transporter activity
A16R_RS04445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A16R_RS04445	COG3711	transcriptional antiterminator
A16R_RS04450	COG1447	Phosphotransferase system cellobiose-specific component IIA
A16R_RS04455	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A16R_RS04475	COG3584	3D domain protein
A16R_RS04475	COG1388	LysM domain
A16R_RS04480	COG0577	efflux transmembrane transporter activity
A16R_RS04485	COG1136	(ABC) transporter
A16R_RS04495	COG5522	Integral membrane protein (intg_mem_TP0381)
A16R_RS04510	COG1114	Component of the transport system for branched-chain amino acids
A16R_RS04515	COG3546	catalase activity
A16R_RS04550	COG0586	Pfam SNARE associated Golgi protein
A16R_RS04590	COG0531	amino acid
A16R_RS04595	COG0475	glutathione-regulated potassium exporter activity
A16R_RS04605	COG1737	Transcriptional regulator
A16R_RS04615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16R_RS04615	COG1263	PTS System
A16R_RS04625	COG2259	Doxx family
A16R_RS04640	COG0697	spore germination
A16R_RS04645	COG1522	sequence-specific DNA binding
A16R_RS04660	COG2076	Multidrug Resistance protein
A16R_RS04665	COG1309	transcriptional regulator
A16R_RS04670	COG2814	Major facilitator Superfamily
A16R_RS04675	COG1733	regulation of RNA biosynthetic process
A16R_RS04685	COG2249	NAD(P)H dehydrogenase (quinone) activity
A16R_RS04690	COG4533	DNA binding
A16R_RS04695	COG2211	Major facilitator Superfamily
A16R_RS04705	COG0693	protein deglycase activity
A16R_RS04710	COG0693	protein deglycase activity
A16R_RS04710	COG0753	catalase activity
A16R_RS04720	COG0531	amino acid
A16R_RS04725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A16R_RS04735	COG1012	belongs to the aldehyde dehydrogenase family
A16R_RS04755	COG1132	(ABC) transporter
A16R_RS04770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16R_RS04775	COG0765	amino acid transport
A16R_RS04780	COG1126	abc transporter atp-binding protein
A16R_RS04795	COG0189	ligase activity
A16R_RS04825	COG0028	Belongs to the TPP enzyme family
A16R_RS04830	COG3527	Alpha-acetolactate decarboxylase
A16R_RS04845	COG0561	phosphatase activity
A16R_RS04865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A16R_RS04880	COG0659	secondary active sulfate transmembrane transporter activity
A16R_RS04900	COG0653	protein targeting
A16R_RS04905	COG2244	polysaccharide biosynthetic process
A16R_RS04915	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16R_RS04920	COG4196	transglutaminase domain protein
A16R_RS04935	COG1696	Membrane protein involved in D-alanine export
A16R_RS04955	COG1024	Enoyl-CoA hydratase
A16R_RS04975	COG1363	Peptidase, m42
A16R_RS04995	COG3938	Belongs to the proline racemase family
A16R_RS05030	COG0601	transmembrane transport
A16R_RS05035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16R_RS05045	COG4608	Belongs to the ABC transporter superfamily
A16R_RS05055	COG0322	excinuclease ABC activity
A16R_RS05090	COG0477	Major facilitator Superfamily
A16R_RS05095	COG3290	protein histidine kinase activity
A16R_RS05100	COG4565	transcriptional regulatory protein
A16R_RS05105	COG3181	Tripartite tricarboxylate transporter family receptor
A16R_RS05135	COG4978	Transcriptional regulator
A16R_RS05135	COG0789	Transcriptional regulator
A16R_RS05150	COG0305	Participates in initiation and elongation during chromosome replication
A16R_RS05200	COG0477	Major facilitator Superfamily
A16R_RS05250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A16R_RS05250	COG3320	Male sterility
A16R_RS05255	COG1309	transcriptional regulator
A16R_RS05275	COG1183	phosphatidylcholine synthase activity
A16R_RS05300	COG2376	Dihydroxyacetone kinase
A16R_RS05315	COG2376	Dihydroxyacetone kinase
A16R_RS05320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A16R_RS05325	COG1959	2 iron, 2 sulfur cluster binding
A16R_RS05360	COG3437	response regulator, receiver
A16R_RS05360	COG2770	Histidine kinase
A16R_RS05425	COG3237	CsbD-like
A16R_RS05450	COG1191	sigma factor activity
A16R_RS05460	COG2208	phosphoserine phosphatase activity
A16R_RS05465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A16R_RS05470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16R_RS05470	COG0784	Response regulator, receiver
A16R_RS05470	COG2198	Histidine kinase
A16R_RS05470	COG2205	protein histidine kinase activity
A16R_RS05530	COG0420	3'-5' exonuclease activity
A16R_RS05535	COG4717	serine-type aminopeptidase activity
A16R_RS05555	COG1309	transcriptional regulator
A16R_RS05560	COG2814	Major facilitator Superfamily
A16R_RS05565	COG0346	lactoylglutathione lyase activity
A16R_RS05570	COG0346	lactoylglutathione lyase activity
A16R_RS05575	COG0457	Tetratricopeptide repeat
A16R_RS05585	COG2267	carboxylic ester hydrolase activity
A16R_RS05605	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A16R_RS05610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A16R_RS05620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A16R_RS05665	COG0477	Major facilitator Superfamily
A16R_RS05670	COG0477	Major facilitator Superfamily
A16R_RS05680	COG3973	AAA domain
A16R_RS05685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A16R_RS05710	COG4980	gas vesicle protein
A16R_RS05715	COG0537	adenosine 5'-monophosphoramidase activity
A16R_RS05725	COG1131	(ABC) transporter
A16R_RS05730	COG4473	ABC transporter
A16R_RS05745	COG1309	transcriptional regulator
A16R_RS05755	COG3402	PFAM membrane-flanked domain
A16R_RS05805	COG3402	PFAM membrane-flanked domain
A16R_RS05810	COG3428	Bacterial PH domain
A16R_RS05815	COG2329	Antibiotic biosynthesis monooxygenase
A16R_RS05820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16R_RS05825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A16R_RS05830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A16R_RS05835	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A16R_RS05870	COG1309	transcriptional regulator
A16R_RS05875	COG1511	domain protein
A16R_RS05900	COG1609	Transcriptional regulator
A16R_RS05910	COG1234	tRNA 3'-trailer cleavage
A16R_RS05915	COG0095	Lipoate-protein ligase
A16R_RS05925	COG0318	PFAM AMP-dependent synthetase and ligase
A16R_RS05955	COG3209	COG3209 Rhs family protein
A16R_RS06000	COG1408	metallophosphoesterase
A16R_RS06005	COG1078	dGTPase activity
A16R_RS06015	COG1595	DNA-templated transcription, initiation
A16R_RS06020	COG3708	Transcriptional regulator
A16R_RS06020	COG2207	Transcriptional regulator
A16R_RS06035	COG2205	protein histidine kinase activity
A16R_RS06040	COG0745	RESPONSE REGULATOR receiver
A16R_RS06065	COG0501	Belongs to the peptidase M48B family
A16R_RS06070	COG0840	transmembrane signaling receptor activity
A16R_RS06075	COG0697	spore germination
A16R_RS06095	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A16R_RS06100	COG2224	Isocitrate lyase
A16R_RS06125	COG4903	ComK protein
A16R_RS06130	COG0398	Pfam SNARE associated Golgi protein
A16R_RS06140	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A16R_RS06145	COG1074	ATP-dependent DNA helicase activity
A16R_RS06190	COG0179	Fumarylacetoacetate (FAA) hydrolase
A16R_RS06215	COG0367	asparagine synthase
A16R_RS06220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A16R_RS06225	COG0753	catalase activity
A16R_RS06230	COG0004	ammonium transporteR
A16R_RS06255	COG2996	Protein conserved in bacteria
A16R_RS06265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A16R_RS06275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16R_RS06290	COG0561	phosphatase activity
A16R_RS06305	COG0542	response to heat
A16R_RS06315	COG2267	carboxylic ester hydrolase activity
A16R_RS06335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16R_RS06340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A16R_RS06345	COG5504	Zn-dependent protease
A16R_RS06360	COG0180	Tryptophanyl-tRNA synthetase
A16R_RS06375	COG4166	transmembrane transport
A16R_RS06380	COG0601	transmembrane transport
A16R_RS06385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16R_RS06390	COG0444	Belongs to the ABC transporter superfamily
A16R_RS06395	COG4608	Belongs to the ABC transporter superfamily
A16R_RS06400	COG0534	Mate efflux family protein
A16R_RS06405	COG4166	transmembrane transport
A16R_RS06425	COG0861	Integral membrane protein TerC family
A16R_RS06430	COG4862	establishment of competence for transformation
A16R_RS06435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16R_RS06445	COG1164	Oligoendopeptidase f
A16R_RS06455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A16R_RS06460	COG2346	COG2346, Truncated hemoglobins
A16R_RS06465	COG4116	CYTH
A16R_RS06475	COG2357	RelA SpoT domain protein
A16R_RS06485	COG0564	pseudouridine synthase activity
A16R_RS06515	COG1216	Glycosyl transferase, family 2
A16R_RS06515	COG0463	Glycosyl transferase, family 2
A16R_RS06535	COG0457	Tetratricopeptide repeat
A16R_RS06535	COG0463	Glycosyl transferase, family 2
A16R_RS06555	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A16R_RS06570	COG1091	dTDP-4-dehydrorhamnose reductase activity
A16R_RS06615	COG2153	protein acetylation
A16R_RS06625	COG2382	esterase
A16R_RS06640	COG5492	domain, Protein
A16R_RS06645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16R_RS06660	COG0512	Glutamine amidotransferase of anthranilate synthase
A16R_RS06660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A16R_RS06695	COG1620	l-lactate permease
A16R_RS06700	COG5634	Uncharacterized conserved protein (DUF2278)
A16R_RS06760	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16R_RS06770	COG1476	TRANSCRIPTIONal
A16R_RS06830	COG2226	methyltransferase
A16R_RS06845	COG1686	Belongs to the peptidase S11 family
A16R_RS06850	COG0681	Belongs to the peptidase S26 family
A16R_RS06885	COG1012	belongs to the aldehyde dehydrogenase family
A16R_RS06890	COG3842	ATPase activity
A16R_RS06895	COG1176	ABC-type spermidine putrescine transport system, permease component I
A16R_RS06900	COG1177	transmembrane transport
A16R_RS06905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A16R_RS06915	COG2409	Drug exporters of the RND superfamily
A16R_RS06925	COG0564	pseudouridine synthase activity
A16R_RS06935	COG2340	Cysteine-rich secretory protein family
A16R_RS06940	COG0247	lactate metabolic process
A16R_RS06945	COG0277	FAD linked oxidase domain protein
A16R_RS06950	COG3835	regulator
A16R_RS06960	COG0745	RESPONSE REGULATOR receiver
A16R_RS06965	COG5002	protein histidine kinase activity
A16R_RS06970	COG2186	Transcriptional regulator
A16R_RS06990	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A16R_RS07000	COG2116	formate transmembrane transporter activity
A16R_RS07005	COG0861	Integral membrane protein TerC family
A16R_RS07010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A16R_RS07020	COG2030	dehydratase
A16R_RS07040	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS07045	COG3243	poly(R)-hydroxyalkanoic acid synthase
A16R_RS07050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16R_RS07055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A16R_RS07075	COG1840	ABC-type Fe3 transport system, periplasmic component
A16R_RS07105	COG1349	DNA-binding transcription factor activity
A16R_RS07130	COG2861	carbohydrate metabolic process
A16R_RS07140	COG3852	Histidine kinase
A16R_RS07145	COG1846	Transcriptional regulator
A16R_RS07155	COG2318	DinB family
A16R_RS07165	COG5002	protein histidine kinase activity
A16R_RS07175	COG0720	synthase
A16R_RS07190	COG4873	Protein conserved in bacteria
A16R_RS07225	COG1780	Probably involved in ribonucleotide reductase function
A16R_RS07245	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A16R_RS07250	COG1725	Transcriptional regulator
A16R_RS07255	COG1131	(ABC) transporter
A16R_RS07265	COG1131	(ABC) transporter
A16R_RS07270	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A16R_RS07285	COG1522	sequence-specific DNA binding
A16R_RS07295	COG1335	isochorismatase
A16R_RS07305	COG1619	proteins homologs of microcin C7 resistance protein MccF
A16R_RS07310	COG2070	2-Nitropropane dioxygenase
A16R_RS07315	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A16R_RS07325	COG1696	Membrane protein involved in D-alanine export
A16R_RS07350	COG0716	FMN binding
A16R_RS07365	COG3173	Aminoglycoside phosphotransferase
A16R_RS07390	COG0534	Mate efflux family protein
A16R_RS07395	COG1968	undecaprenyl-diphosphatase activity
A16R_RS07410	COG1846	Transcriptional regulator
A16R_RS07420	COG1301	dicarboxylic acid transport
A16R_RS07425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A16R_RS07430	COG4709	membrane
A16R_RS07435	COG3874	Sporulation protein YtfJ
A16R_RS07465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16R_RS07470	COG0028	Belongs to the TPP enzyme family
A16R_RS07475	COG0440	acetolactate synthase activity
A16R_RS07480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A16R_RS07490	COG0473	3-isopropylmalate dehydrogenase activity
A16R_RS07515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A16R_RS07550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A16R_RS07565	COG1183	phosphatidylcholine synthase activity
A16R_RS07570	COG1368	sulfuric ester hydrolase activity
A16R_RS07580	COG0019	diaminopimelate decarboxylase activity
A16R_RS07600	COG0529	Catalyzes the synthesis of activated sulfate
A16R_RS07605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A16R_RS07625	COG1648	precorrin-2 dehydrogenase activity
A16R_RS07635	COG0733	neurotransmitter:sodium symporter activity
A16R_RS07655	COG1757	Na H antiporter
A16R_RS07670	COG4758	membrane
A16R_RS07675	COG4585	Histidine kinase
A16R_RS07680	COG2197	response regulator
A16R_RS07690	COG1114	Component of the transport system for branched-chain amino acids
A16R_RS07700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A16R_RS07725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A16R_RS07725	COG1017	nitric oxide dioxygenase activity
A16R_RS07745	COG0730	response to heat
A16R_RS07750	COG0306	phosphate transporter
A16R_RS07755	COG1392	Phosphate transport regulator
A16R_RS07760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16R_RS07785	COG1801	Protein of unknown function DUF72
A16R_RS07795	COG0582	viral genome integration into host DNA
A16R_RS07800	COG5002	protein histidine kinase activity
A16R_RS07830	COG0392	lysyltransferase activity
A16R_RS07830	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A16R_RS07845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A16R_RS07850	COG1686	Belongs to the peptidase S11 family
A16R_RS07855	COG2715	membrane protein required for spore maturation
A16R_RS07860	COG0700	Nucleoside recognition
A16R_RS07865	COG1187	pseudouridine synthase activity
A16R_RS07875	COG1333	cytochrome c biogenesis protein
A16R_RS07880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A16R_RS07885	COG0745	RESPONSE REGULATOR receiver
A16R_RS07890	COG5002	protein histidine kinase activity
A16R_RS07895	COG2096	Adenosyltransferase
A16R_RS07910	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A16R_RS07915	COG1141	Ferredoxin
A16R_RS07920	COG4955	Helix-turn-helix domain
A16R_RS07925	COG0514	ATP-dependent DNA helicase (RecQ)
A16R_RS07930	COG1266	CAAX protease self-immunity
A16R_RS07950	COG4862	establishment of competence for transformation
A16R_RS07955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A16R_RS07975	COG0492	ferredoxin-NADP+ reductase activity
A16R_RS08050	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A16R_RS08065	COG0142	geranyltranstransferase activity
A16R_RS08075	COG0142	geranyltranstransferase activity
A16R_RS08095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A16R_RS08100	COG0457	Tetratricopeptide repeat
A16R_RS08120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A16R_RS08135	COG4347	Protein of unknown function (DUF1405)
A16R_RS08150	COG2738	Putative neutral zinc metallopeptidase
A16R_RS08160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16R_RS08170	COG1694	Mazg nucleotide pyrophosphohydrolase
A16R_RS08185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A16R_RS08190	COG0438	transferase activity, transferring glycosyl groups
A16R_RS08230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A16R_RS08230	COG1199	ATP-dependent helicase activity
A16R_RS08250	COG3935	DnaD domain protein
A16R_RS08255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A16R_RS08265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16R_RS08265	COG4499	WXG100 protein secretion system (Wss), protein YukC
A16R_RS08325	COG0116	Belongs to the methyltransferase superfamily
A16R_RS08335	COG1199	ATP-dependent helicase activity
A16R_RS08340	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A16R_RS08350	COG3173	Aminoglycoside phosphotransferase
A16R_RS08355	COG0024	Methionine aminopeptidase
A16R_RS08365	COG2233	PERMEase
A16R_RS08370	COG2311	Membrane
A16R_RS08380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A16R_RS08390	COG0456	acetyltransferase
A16R_RS08425	COG0754	glutathionylspermidine amidase activity
A16R_RS08440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A16R_RS08470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A16R_RS08485	COG1215	transferase activity, transferring glycosyl groups
A16R_RS08490	COG0438	transferase activity, transferring glycosyl groups
A16R_RS08505	COG0454	-acetyltransferase
A16R_RS08525	COG0328	RNA-DNA hybrid ribonuclease activity
A16R_RS08565	COG1280	lysine exporter protein (LysE YggA)
A16R_RS08580	COG3162	membrane
A16R_RS08585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16R_RS08590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A16R_RS08605	COG0475	glutathione-regulated potassium exporter activity
A16R_RS08610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A16R_RS08615	COG4978	Transcriptional regulator
A16R_RS08615	COG0789	Transcriptional regulator
A16R_RS08625	COG2323	membrane
A16R_RS08630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A16R_RS08685	COG1923	regulation of RNA biosynthetic process
A16R_RS08695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A16R_RS08700	COG1360	Flagellar Motor Protein
A16R_RS08705	COG2201	protein-glutamate methylesterase activity
A16R_RS08710	COG2198	Histidine kinase
A16R_RS08710	COG0643	Histidine kinase
A16R_RS08715	COG0643	Histidine kinase
A16R_RS08715	COG2198	Histidine kinase
A16R_RS08720	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A16R_RS08720	COG1776	CheC inhibitor of MCP methylation
A16R_RS08735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A16R_RS08755	COG1256	bacterial-type flagellum assembly
A16R_RS08780	COG1815	bacterial-type flagellum-dependent cell motility
A16R_RS08785	COG1558	bacterial-type flagellum-dependent cell motility
A16R_RS08800	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A16R_RS08810	COG1157	protein secretion by the type III secretion system
A16R_RS08865	COG0463	Glycosyl transferase, family 2
A16R_RS08915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A16R_RS08920	COG0741	lytic transglycosylase activity
A16R_RS08935	COG1776	CheC inhibitor of MCP methylation
A16R_RS08935	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A16R_RS08945	COG1338	Plays a role in the flagellum-specific transport system
A16R_RS08950	COG1987	bacterial-type flagellum assembly
A16R_RS08960	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A16R_RS08965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A16R_RS08975	COG4786	Flagellar basal body rod
A16R_RS08980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A16R_RS09005	COG1309	transcriptional regulator
A16R_RS09025	COG2329	Antibiotic biosynthesis monooxygenase
A16R_RS09050	COG0583	DNA-binding transcription factor activity
A16R_RS09055	COG3842	ATPase activity
A16R_RS09060	COG0725	ABC transporter, periplasmic molybdate-binding protein
A16R_RS09070	COG1234	tRNA 3'-trailer cleavage
A16R_RS09100	COG1686	Belongs to the peptidase S11 family
A16R_RS09110	COG0406	alpha-ribazole phosphatase activity
A16R_RS09140	COG0367	asparagine synthase
A16R_RS09170	COG1802	Transcriptional regulator
A16R_RS09175	COG0697	spore germination
A16R_RS09180	COG0523	cobalamin synthesis protein
A16R_RS09190	COG0701	Predicted permease
A16R_RS09200	COG1216	Glycosyl transferase, family 2
A16R_RS09200	COG0438	transferase activity, transferring glycosyl groups
A16R_RS09205	COG1757	Na H antiporter
A16R_RS09210	COG0114	fumarate hydratase activity
A16R_RS09240	COG3340	Belongs to the peptidase S51 family
A16R_RS09260	COG0785	Cytochrome C biogenesis protein
A16R_RS09295	COG2733	membrane
A16R_RS09335	COG1131	(ABC) transporter
A16R_RS09350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16R_RS09355	COG0528	UMP kinase activity
A16R_RS09365	COG1027	Aspartate ammonia-lyase
A16R_RS09370	COG0281	malic enzyme
A16R_RS09375	COG4191	Histidine kinase
A16R_RS09380	COG0784	Response regulator, receiver
A16R_RS09385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A16R_RS09450	COG1051	belongs to the nudix hydrolase family
A16R_RS09455	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16R_RS09465	COG2814	Major facilitator Superfamily
A16R_RS09480	COG1966	Carbon starvation protein
A16R_RS09500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16R_RS09510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A16R_RS09520	COG2223	nitrite transmembrane transporter activity
A16R_RS09525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A16R_RS09540	COG2244	polysaccharide biosynthetic process
A16R_RS09545	COG0733	neurotransmitter:sodium symporter activity
A16R_RS09555	COG5566	PFAM Mor transcription activator
A16R_RS09560	COG2323	membrane
A16R_RS09580	COG2084	Dehydrogenase
A16R_RS09600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A16R_RS09610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16R_RS09615	COG0028	Belongs to the TPP enzyme family
A16R_RS09620	COG0440	acetolactate synthase activity
A16R_RS09625	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A16R_RS09635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A16R_RS09660	COG2814	Major facilitator Superfamily
A16R_RS09665	COG3384	dioxygenase
A16R_RS09675	COG3279	Response regulator of the LytR AlgR family
A16R_RS09680	COG0427	acetyl-CoA hydrolase
A16R_RS09700	COG1073	alpha beta
A16R_RS09705	COG1131	(ABC) transporter
A16R_RS09710	COG4166	transmembrane transport
A16R_RS09745	COG0535	radical SAM domain protein
A16R_RS09750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16R_RS09770	COG1914	H( )-stimulated, divalent metal cation uptake system
A16R_RS09785	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A16R_RS09820	COG2390	Transcriptional regulator
A16R_RS09830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16R_RS09835	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A16R_RS09850	COG4224	UPF0291 protein
A16R_RS09870	COG0006	proline dipeptidase activity
A16R_RS09875	COG2132	Multicopper oxidase
A16R_RS09905	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A16R_RS09920	COG1276	copper resistance
A16R_RS09920	COG2372	response to copper ion
A16R_RS09925	COG4549	nuclear export factor GLE1
A16R_RS09935	COG0697	spore germination
A16R_RS09940	COG0583	DNA-binding transcription factor activity
A16R_RS09945	COG1959	2 iron, 2 sulfur cluster binding
A16R_RS09950	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A16R_RS09955	COG0778	Nitroreductase
A16R_RS09970	COG0628	permease
A16R_RS09980	COG1231	oxidoreductase activity
A16R_RS09985	COG0523	cobalamin synthesis protein
A16R_RS10000	COG0318	PFAM AMP-dependent synthetase and ligase
A16R_RS10005	COG2030	dehydratase
A16R_RS10010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16R_RS10025	COG0411	ABC transporter
A16R_RS10045	COG0583	DNA-binding transcription factor activity
A16R_RS10065	COG1846	Transcriptional regulator
A16R_RS10075	COG1271	oxidase subunit
A16R_RS10080	COG1294	oxidase, subunit
A16R_RS10085	COG4988	ABC transporter
A16R_RS10090	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A16R_RS10110	COG1686	Belongs to the peptidase S11 family
A16R_RS10125	COG1388	LysM domain
A16R_RS10125	COG0791	NLP P60 protein
A16R_RS10140	COG0745	RESPONSE REGULATOR receiver
A16R_RS10145	COG5002	protein histidine kinase activity
A16R_RS10155	COG0300	oxidoreductase activity
A16R_RS10195	COG0460	homoserine dehydrogenase
A16R_RS10220	COG1316	TRANSCRIPTIONal
A16R_RS10230	COG0745	RESPONSE REGULATOR receiver
A16R_RS10235	COG5002	protein histidine kinase activity
A16R_RS10250	COG1285	pathogenesis
A16R_RS10255	COG1247	-acetyltransferase
A16R_RS10275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A16R_RS10285	COG1082	Xylose isomerase domain protein TIM barrel
A16R_RS10300	COG1279	arginine transmembrane transporter activity
A16R_RS10315	COG1752	Esterase of the alpha-beta hydrolase superfamily
A16R_RS10355	COG2002	toxin-antitoxin pair type II binding
A16R_RS10360	COG1404	Belongs to the peptidase S8 family
A16R_RS10365	COG0640	Transcriptional regulator
A16R_RS10370	COG0667	Aldo Keto reductase
A16R_RS10380	COG2814	Major facilitator Superfamily
A16R_RS10405	COG0840	transmembrane signaling receptor activity
A16R_RS10425	COG3949	Membrane
A16R_RS10430	COG0783	Belongs to the Dps family
A16R_RS10445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A16R_RS10455	COG1231	oxidoreductase activity
A16R_RS10465	COG4989	oxidoreductase activity
A16R_RS10470	COG0523	cobalamin synthesis protein
A16R_RS10475	COG0456	acetyltransferase
A16R_RS10555	COG0803	Belongs to the bacterial solute-binding protein 9 family
A16R_RS10555	COG3443	Belongs to the bacterial solute-binding protein 9 family
A16R_RS10565	COG0702	epimerase
A16R_RS10575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A16R_RS10585	COG4166	transmembrane transport
A16R_RS10600	COG0406	alpha-ribazole phosphatase activity
A16R_RS10610	COG5337	Spore coat protein CotH
A16R_RS10615	COG1051	belongs to the nudix hydrolase family
A16R_RS10620	COG0586	Pfam SNARE associated Golgi protein
A16R_RS10625	COG2244	polysaccharide biosynthetic process
A16R_RS10635	COG0701	Predicted permease
A16R_RS10640	COG3689	TIGRFAM TIGR03943 family protein
A16R_RS10645	COG1607	acyl-coa hydrolase
A16R_RS10655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16R_RS10670	COG0702	epimerase
A16R_RS10675	COG2839	Protein conserved in bacteria
A16R_RS10680	COG1253	flavin adenine dinucleotide binding
A16R_RS10695	COG1114	Component of the transport system for branched-chain amino acids
A16R_RS10700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16R_RS10720	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16R_RS10730	COG1876	peptidase activity
A16R_RS10740	COG0154	amidase activity
A16R_RS10745	COG2211	Major facilitator Superfamily
A16R_RS10765	COG0561	phosphatase activity
A16R_RS10775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A16R_RS10780	COG4106	trans-aconitate 2-methyltransferase activity
A16R_RS10795	COG1819	glycosyl
A16R_RS10800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16R_RS10805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16R_RS10835	COG0456	acetyltransferase
A16R_RS10895	COG3874	Sporulation protein YtfJ
A16R_RS10920	COG2226	methyltransferase
A16R_RS10940	COG1082	Xylose isomerase domain protein TIM barrel
A16R_RS10945	COG0346	lactoylglutathione lyase activity
A16R_RS10955	COG0604	alcohol dehydrogenase
A16R_RS10960	COG1595	DNA-templated transcription, initiation
A16R_RS10985	COG0386	Belongs to the glutathione peroxidase family
A16R_RS10990	COG1305	Transglutaminase-like
A16R_RS10995	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
A16R_RS11000	COG0714	Associated with various cellular activities
A16R_RS11015	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A16R_RS11020	COG1140	nitrate reductase beta subunit
A16R_RS11025	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A16R_RS11030	COG2181	nitrate reductase activity
A16R_RS11050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A16R_RS11055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A16R_RS11060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16R_RS11065	COG0303	'Molybdopterin
A16R_RS11070	COG0314	molybdopterin synthase activity
A16R_RS11080	COG2223	nitrite transmembrane transporter activity
A16R_RS11100	COG1648	precorrin-2 dehydrogenase activity
A16R_RS11110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A16R_RS11110	COG1587	Uroporphyrinogen-III synthase
A16R_RS11115	COG2146	nitrite reductase [NAD(P)H] activity
A16R_RS11120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A16R_RS11125	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A16R_RS11160	COG2359	stage V sporulation protein S
A16R_RS11180	COG5632	N-Acetylmuramoyl-L-alanine amidase
A16R_RS11195	COG1418	mRNA catabolic process
A16R_RS11200	COG0488	(ABC) transporter
A16R_RS11215	COG0629	single-stranded DNA binding
A16R_RS11230	COG1413	lyase activity
A16R_RS11245	COG2521	methyltransferase
A16R_RS11245	COG2136	Putative SAM-dependent methyltransferase
A16R_RS11250	COG0018	arginyl-trna synthetase
A16R_RS11280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A16R_RS11300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A16R_RS11305	COG0017	Asparaginyl-tRNA synthetase
A16R_RS11325	COG1674	ftsk spoiiie
A16R_RS11420	COG1929	Belongs to the glycerate kinase type-1 family
A16R_RS11425	COG0471	metal ion transport
A16R_RS11430	COG0745	RESPONSE REGULATOR receiver
A16R_RS11435	COG3850	Histidine kinase
A16R_RS11435	COG5002	protein histidine kinase activity
A16R_RS11450	COG0733	neurotransmitter:sodium symporter activity
A16R_RS11475	COG2610	gluconate transmembrane transporter activity
A16R_RS11480	COG1454	alcohol dehydrogenase
A16R_RS11485	COG1794	racemase activity, acting on amino acids and derivatives
A16R_RS11495	COG0456	acetyltransferase
A16R_RS11510	COG1131	(ABC) transporter
A16R_RS11525	COG0546	phosphoglycolate phosphatase activity
A16R_RS11545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16R_RS11560	COG0768	penicillin binding
A16R_RS11565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A16R_RS11570	COG0204	Acyl-transferase
A16R_RS11575	COG1272	protein, Hemolysin III
A16R_RS11585	COG0805	protein transport
A16R_RS11600	COG1307	EDD domain protein, DegV family
A16R_RS11605	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A16R_RS11610	COG1999	signal sequence binding
A16R_RS11615	COG0071	Belongs to the small heat shock protein (HSP20) family
A16R_RS11620	COG0367	asparagine synthase
A16R_RS11640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16R_RS11645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A16R_RS11670	COG1051	belongs to the nudix hydrolase family
A16R_RS11680	COG0668	transmembrane transport
A16R_RS11685	COG4585	Histidine kinase
A16R_RS11685	COG2203	Gaf domain
A16R_RS11690	COG2197	response regulator
A16R_RS11700	COG1064	alcohol dehydrogenase
A16R_RS11725	COG1070	Carbohydrate kinase
A16R_RS11730	COG1070	Carbohydrate kinase
A16R_RS11760	COG0517	IMP dehydrogenase activity
A16R_RS11760	COG1125	glycine betaine transport
A16R_RS11765	COG1174	glycine betaine transport
A16R_RS11800	COG1253	flavin adenine dinucleotide binding
A16R_RS11805	COG1012	belongs to the aldehyde dehydrogenase family
A16R_RS11810	COG5506	Protein of unknown function (DUF1694)
A16R_RS11830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A16R_RS11835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A16R_RS11840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A16R_RS11845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A16R_RS11850	COG0456	acetyltransferase
A16R_RS11855	COG3829	transcription factor binding
A16R_RS11865	COG1509	lysine 2,3-aminomutase activity
A16R_RS11905	COG4326	sporulation control protein
A16R_RS11910	COG0671	phosphoesterase, PA-phosphatase related
A16R_RS11915	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A16R_RS11920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16R_RS11950	COG1715	Restriction endonuclease
A16R_RS11950	COG1787	Restriction endonuclease
A16R_RS12065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A16R_RS12105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16R_RS12105	COG4499	WXG100 protein secretion system (Wss), protein YukC
A16R_RS12110	COG2814	Major facilitator Superfamily
A16R_RS12115	COG4841	protein insertion into membrane
A16R_RS12120	COG0372	Belongs to the citrate synthase family
A16R_RS12125	COG2079	MmgE PrpD family protein
A16R_RS12130	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A16R_RS12135	COG1960	acyl-CoA dehydrogenase activity
A16R_RS12140	COG2084	Dehydrogenase
A16R_RS12150	COG1280	lysine exporter protein (LysE YggA)
A16R_RS12155	COG1024	Enoyl-CoA hydratase
A16R_RS12170	COG0420	3'-5' exonuclease activity
A16R_RS12175	COG0419	ATPase involved in DNA repair
A16R_RS12210	COG2223	nitrite transmembrane transporter activity
A16R_RS12220	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS12225	COG1169	isochorismate synthase
A16R_RS12230	COG1021	2,3-dihydroxybenzoate-AMP ligase
A16R_RS12235	COG1535	isochorismatase
A16R_RS12235	COG3433	isochorismatase activity
A16R_RS12240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A16R_RS12245	COG3251	PFAM MbtH domain protein
A16R_RS12250	COG2814	Major facilitator Superfamily
A16R_RS12265	COG0776	regulation of translation
A16R_RS12275	COG2318	DinB family
A16R_RS12285	COG1115	amino acid carrier protein
A16R_RS12300	COG2329	Antibiotic biosynthesis monooxygenase
A16R_RS12305	COG1187	pseudouridine synthase activity
A16R_RS12310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A16R_RS12330	COG0596	Alpha beta hydrolase
A16R_RS12335	COG2814	Major facilitator Superfamily
A16R_RS12355	COG2226	methyltransferase
A16R_RS12400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16R_RS12435	COG1247	-acetyltransferase
A16R_RS12465	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A16R_RS12475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16R_RS12485	COG1278	Cold shock
A16R_RS12500	COG0010	Belongs to the arginase family
A16R_RS12505	COG0561	phosphatase activity
A16R_RS12555	COG0583	DNA-binding transcription factor activity
A16R_RS12560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A16R_RS12575	COG0583	DNA-binding transcription factor activity
A16R_RS12580	COG2258	MOSC domain
A16R_RS12595	COG1132	(ABC) transporter
A16R_RS12600	COG1132	(ABC) transporter
A16R_RS12620	COG1396	sequence-specific DNA binding
A16R_RS12645	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A16R_RS12650	COG1595	DNA-templated transcription, initiation
A16R_RS12680	COG1649	PFAM Uncharacterised BCR, COG1649
A16R_RS12710	COG2971	BadF BadG BcrA BcrD
A16R_RS12715	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A16R_RS12720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A16R_RS12750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16R_RS12780	COG1309	transcriptional regulator
A16R_RS12795	COG1136	(ABC) transporter
A16R_RS12795	COG0577	efflux transmembrane transporter activity
A16R_RS12800	COG3615	Tellurite resistance protein tehB
A16R_RS12800	COG0500	methyltransferase
A16R_RS12810	COG2226	methyltransferase
A16R_RS12815	COG3961	Belongs to the TPP enzyme family
A16R_RS12820	COG1846	Transcriptional regulator
A16R_RS12870	COG2195	Cleaves the N-terminal amino acid of tripeptides
A16R_RS12890	COG1595	DNA-templated transcription, initiation
A16R_RS12900	COG0768	penicillin binding
A16R_RS12910	COG2367	Beta-lactamase
A16R_RS12915	COG0671	phosphoesterase, PA-phosphatase related
A16R_RS12920	COG1609	Transcriptional regulator
A16R_RS12925	COG2814	Major facilitator Superfamily
A16R_RS12930	COG0673	inositol 2-dehydrogenase activity
A16R_RS12940	COG1012	belongs to the aldehyde dehydrogenase family
A16R_RS12955	COG0191	fructose-bisphosphate aldolase activity
A16R_RS12960	COG3718	enzyme involved in inositol metabolism
A16R_RS12985	COG0457	Tetratricopeptide repeat
A16R_RS12990	COG1476	TRANSCRIPTIONal
A16R_RS13005	COG1876	peptidase activity
A16R_RS13025	COG1309	transcriptional regulator
A16R_RS13030	COG0488	(ABC) transporter
A16R_RS13045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16R_RS13060	COG1252	NADH dehydrogenase
A16R_RS13065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16R_RS13080	COG1131	(ABC) transporter
A16R_RS13090	COG1309	transcriptional regulator
A16R_RS13110	COG1960	acyl-CoA dehydrogenase activity
A16R_RS13115	COG0439	Biotin carboxylase
A16R_RS13120	COG0511	ligase activity, forming carbon-carbon bonds
A16R_RS13125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A16R_RS13130	COG1024	Enoyl-CoA hydratase
A16R_RS13135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A16R_RS13140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A16R_RS13150	COG1247	-acetyltransferase
A16R_RS13155	COG0572	uridine kinase
A16R_RS13165	COG2318	DinB family
A16R_RS13170	COG1686	Belongs to the peptidase S11 family
A16R_RS13195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A16R_RS13235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A16R_RS13235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A16R_RS13260	COG2814	Major facilitator Superfamily
A16R_RS13280	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A16R_RS13300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16R_RS13315	COG1063	alcohol dehydrogenase
A16R_RS13345	COG3773	Cell wall hydrolase
A16R_RS13360	COG0745	RESPONSE REGULATOR receiver
A16R_RS13390	COG1136	(ABC) transporter
A16R_RS13415	COG0460	homoserine dehydrogenase
A16R_RS13420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16R_RS13430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A16R_RS13525	COG2124	cytochrome p450
A16R_RS13560	COG0561	phosphatase activity
A16R_RS13570	COG5002	protein histidine kinase activity
A16R_RS13575	COG0768	penicillin binding
A16R_RS13580	COG1819	glycosyl
A16R_RS13585	COG1794	racemase activity, acting on amino acids and derivatives
A16R_RS13595	COG1122	ATPase activity
A16R_RS13610	COG2205	protein histidine kinase activity
A16R_RS13620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A16R_RS13625	COG0604	alcohol dehydrogenase
A16R_RS13630	COG0768	penicillin binding
A16R_RS13640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16R_RS13675	COG0693	protein deglycase activity
A16R_RS13715	COG2814	Major facilitator Superfamily
A16R_RS13735	COG0584	glycerophosphoryl diester phosphodiesterase
A16R_RS13755	COG0697	spore germination
A16R_RS13785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16R_RS13795	COG2223	nitrite transmembrane transporter activity
A16R_RS13810	COG2816	NAD+ diphosphatase activity
A16R_RS13815	COG0592	DNA-directed DNA polymerase activity
A16R_RS13820	COG1051	belongs to the nudix hydrolase family
A16R_RS13855	COG3878	Protein conserved in bacteria
A16R_RS13910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A16R_RS13925	COG0322	excinuclease ABC activity
A16R_RS13970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16R_RS13995	COG1011	Hydrolase
A16R_RS14015	COG0076	glutamate decarboxylase activity
A16R_RS14030	COG1523	belongs to the glycosyl hydrolase 13 family
A16R_RS14035	COG3227	Zinc metalloprotease (Elastase)
A16R_RS14055	COG0201	protein transport
A16R_RS14065	COG0697	spore germination
A16R_RS14070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16R_RS14100	COG4129	membrane
A16R_RS14120	COG2959	enzyme of heme biosynthesis
A16R_RS14140	COG3483	tryptophan 2,3-dioxygenase activity
A16R_RS14145	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A16R_RS14150	COG3844	kynureninase activity
A16R_RS14155	COG1309	transcriptional regulator
A16R_RS14190	COG3284	Transcriptional regulator
A16R_RS14210	COG1349	DNA-binding transcription factor activity
A16R_RS14230	COG1959	2 iron, 2 sulfur cluster binding
A16R_RS14250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A16R_RS14255	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16R_RS14260	COG0022	dehydrogenase e1 component
A16R_RS14265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A16R_RS14275	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS14280	COG0456	acetyltransferase
A16R_RS14280	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A16R_RS14315	COG4176	ABC-type proline glycine betaine transport system permease component
A16R_RS14320	COG0517	IMP dehydrogenase activity
A16R_RS14320	COG4175	Glycine betaine
A16R_RS14345	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A16R_RS14350	COG2153	protein acetylation
A16R_RS14355	COG3397	chitin binding
A16R_RS14370	COG2205	protein histidine kinase activity
A16R_RS14400	COG0658	competence protein
A16R_RS14400	COG2333	competence protein COMEC
A16R_RS14450	COG3973	AAA domain
A16R_RS14465	COG2105	PFAM AIG2 family protein
A16R_RS14470	COG0514	ATP-dependent DNA helicase (RecQ)
A16R_RS14500	COG4637	Psort location Cytoplasmic, score
A16R_RS14525	COG3397	chitin binding
A16R_RS14540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A16R_RS14545	COG1115	amino acid carrier protein
A16R_RS14550	COG1012	belongs to the aldehyde dehydrogenase family
A16R_RS14555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A16R_RS14565	COG3938	Belongs to the proline racemase family
A16R_RS14570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A16R_RS14610	COG0586	Pfam SNARE associated Golgi protein
A16R_RS14625	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A16R_RS14630	COG0519	Catalyzes the synthesis of GMP from XMP
A16R_RS14635	COG4166	transmembrane transport
A16R_RS14645	COG4948	Mandelate Racemase Muconate Lactonizing
A16R_RS14695	COG2936	dipeptidyl-peptidase activity
A16R_RS14700	COG5002	protein histidine kinase activity
A16R_RS14740	COG1164	Oligoendopeptidase f
A16R_RS14755	COG1307	EDD domain protein, DegV family
A16R_RS14780	COG2814	Major facilitator Superfamily
A16R_RS14790	COG1664	Polymer-forming cytoskeletal
A16R_RS14795	COG0789	Transcriptional regulator
A16R_RS14800	COG4533	DNA binding
A16R_RS14805	COG2814	Major facilitator Superfamily
A16R_RS14805	COG0477	Major facilitator Superfamily
A16R_RS14825	COG2261	transglycosylase associated protein
A16R_RS14840	COG2226	methyltransferase
A16R_RS14880	COG0436	Aminotransferase
A16R_RS14885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A16R_RS14890	COG5146	pantothenate kinase activity
A16R_RS14960	COG0628	permease
A16R_RS14975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A16R_RS14980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16R_RS14985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A16R_RS14990	COG1116	anion transmembrane transporter activity
A16R_RS15010	COG2816	NAD+ diphosphatase activity
A16R_RS15030	COG2746	aminoglycoside 3-N-acetyltransferase activity
A16R_RS15060	COG0697	spore germination
A16R_RS15065	COG2318	DinB family
A16R_RS15085	COG4912	Dna alkylation repair
A16R_RS15110	COG0861	Integral membrane protein TerC family
A16R_RS15115	COG1368	sulfuric ester hydrolase activity
A16R_RS15125	COG0488	(ABC) transporter
A16R_RS15135	COG1033	growth of symbiont in host cell
A16R_RS15135	COG2409	Drug exporters of the RND superfamily
A16R_RS15140	COG1033	growth of symbiont in host cell
A16R_RS15140	COG2409	Drug exporters of the RND superfamily
A16R_RS15145	COG2409	Drug exporters of the RND superfamily
A16R_RS15145	COG1033	growth of symbiont in host cell
A16R_RS15150	COG1309	transcriptional regulator
A16R_RS15165	COG0287	Prephenate dehydrogenase
A16R_RS15170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A16R_RS15175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A16R_RS15185	COG1605	Chorismate mutase
A16R_RS15185	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A16R_RS15230	COG1388	LysM domain
A16R_RS15230	COG3584	3D domain protein
A16R_RS15245	COG1595	DNA-templated transcription, initiation
A16R_RS15270	COG1879	ABC-type sugar transport system periplasmic component
A16R_RS15280	COG1172	Belongs to the binding-protein-dependent transport system permease family
A16R_RS15290	COG2390	Transcriptional regulator
A16R_RS15325	COG2329	Antibiotic biosynthesis monooxygenase
A16R_RS15345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16R_RS15355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A16R_RS15365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16R_RS15370	COG4187	Peptidase family M20/M25/M40
A16R_RS15375	COG1414	Transcriptional regulator
A16R_RS15385	COG0833	amino acid
A16R_RS15390	COG1690	Belongs to the RtcB family
A16R_RS15395	COG3239	Fatty acid desaturase
A16R_RS15400	COG1785	Belongs to the alkaline phosphatase family
A16R_RS15410	COG3655	Transcriptional regulator
A16R_RS15425	COG4377	Putative membrane peptidase family (DUF2324)
A16R_RS15435	COG3279	Response regulator of the LytR AlgR family
A16R_RS15445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16R_RS15450	COG0346	lactoylglutathione lyase activity
A16R_RS15470	COG0714	Associated with various cellular activities
A16R_RS15520	COG0463	Glycosyl transferase, family 2
A16R_RS15535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A16R_RS15540	COG0753	catalase activity
A16R_RS15550	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A16R_RS15575	COG0714	Associated with various cellular activities
A16R_RS15585	COG0778	Nitroreductase
A16R_RS15590	COG1846	Transcriptional regulator
A16R_RS15630	COG1725	Transcriptional regulator
A16R_RS15645	COG1136	(ABC) transporter
A16R_RS15645	COG0577	efflux transmembrane transporter activity
A16R_RS15670	COG2207	Transcriptional regulator
A16R_RS15675	COG0456	acetyltransferase
A16R_RS15695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16R_RS15715	COG0642	Histidine kinase
A16R_RS15720	COG0745	RESPONSE REGULATOR receiver
A16R_RS15725	COG0596	Alpha beta hydrolase
A16R_RS15755	COG0730	response to heat
A16R_RS15765	COG0833	amino acid
A16R_RS15775	COG4335	DNA alkylation repair
A16R_RS15815	COG0768	penicillin binding
A16R_RS15825	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A16R_RS15860	COG1984	allophanate hydrolase subunit 2
A16R_RS15865	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A16R_RS15870	COG1414	Transcriptional regulator
A16R_RS15885	COG0860	N-Acetylmuramoyl-L-alanine amidase
A16R_RS15890	COG0640	Transcriptional regulator
A16R_RS15900	COG1960	acyl-CoA dehydrogenase activity
A16R_RS15920	COG3314	Sporulation integral membrane protein YlbJ
A16R_RS15935	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A16R_RS15950	COG0574	Belongs to the PEP-utilizing enzyme family
A16R_RS15950	COG3848	Pyruvate phosphate dikinase
A16R_RS15960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16R_RS15975	COG5577	PFAM Coat F domain
A16R_RS15985	COG3403	YqcI/YcgG family
A16R_RS15990	COG1280	lysine exporter protein (LysE YggA)
A16R_RS16025	COG1063	alcohol dehydrogenase
A16R_RS16040	COG1027	Aspartate ammonia-lyase
A16R_RS16045	COG0252	asparaginase activity
A16R_RS16050	COG1396	sequence-specific DNA binding
A16R_RS16060	COG0322	excinuclease ABC activity
A16R_RS16065	COG0531	amino acid
A16R_RS16070	COG1114	Component of the transport system for branched-chain amino acids
A16R_RS16075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16R_RS16085	COG0281	malic enzyme
A16R_RS16100	COG0531	amino acid
A16R_RS16105	COG0697	spore germination
A16R_RS16115	COG0784	Response regulator, receiver
A16R_RS16125	COG2066	Belongs to the glutaminase family
A16R_RS16160	COG0737	Belongs to the 5'-nucleotidase family
A16R_RS16165	COG0753	catalase activity
A16R_RS16170	COG2267	carboxylic ester hydrolase activity
A16R_RS16175	COG1335	isochorismatase
A16R_RS16195	COG0583	DNA-binding transcription factor activity
A16R_RS16205	COG1846	Transcriptional regulator
A16R_RS16250	COG0415	Belongs to the DNA photolyase family
A16R_RS16255	COG0288	reversible hydration of carbon dioxide
A16R_RS16265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A16R_RS16270	COG5609	conserved protein (DUF2294)
A16R_RS16285	COG1575	Belongs to the MenA family. Type 1 subfamily
A16R_RS16290	COG2267	carboxylic ester hydrolase activity
A16R_RS16300	COG0803	Belongs to the bacterial solute-binding protein 9 family
A16R_RS16305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A16R_RS16310	COG1121	(ABC) transporter
A16R_RS16340	COG0798	PFAM Bile acid sodium symporter
A16R_RS16345	COG0346	lactoylglutathione lyase activity
A16R_RS16350	COG0640	Transcriptional regulator
A16R_RS16365	COG0443	Heat shock 70 kDa protein
A16R_RS16385	COG1522	sequence-specific DNA binding
A16R_RS16400	COG0346	lactoylglutathione lyase activity
A16R_RS16425	COG2169	Transcriptional regulator
A16R_RS16475	COG2814	Major facilitator Superfamily
A16R_RS16505	COG0745	RESPONSE REGULATOR receiver
A16R_RS16510	COG5002	protein histidine kinase activity
A16R_RS16510	COG3850	Histidine kinase
A16R_RS16545	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A16R_RS16575	COG1476	TRANSCRIPTIONal
A16R_RS16590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16R_RS16595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A16R_RS16605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16R_RS16610	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A16R_RS16625	COG1136	(ABC) transporter
A16R_RS16630	COG0577	efflux transmembrane transporter activity
A16R_RS16645	COG5002	protein histidine kinase activity
A16R_RS16645	COG3850	Histidine kinase
A16R_RS16655	COG2364	Membrane
A16R_RS16660	COG1846	Transcriptional regulator
A16R_RS16670	COG2808	Putative FMN-binding domain
A16R_RS16675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16R_RS16680	COG2271	Major facilitator Superfamily
A16R_RS16685	COG1556	Lactate utilization protein
A16R_RS16690	COG1139	Iron-sulfur cluster binding protein
A16R_RS16700	COG0583	DNA-binding transcription factor activity
A16R_RS16710	COG1619	proteins homologs of microcin C7 resistance protein MccF
A16R_RS16740	COG0738	Major facilitator superfamily
A16R_RS16745	COG0673	inositol 2-dehydrogenase activity
A16R_RS16750	COG0561	phosphatase activity
A16R_RS16760	COG1609	Transcriptional regulator
A16R_RS16765	COG0457	Tetratricopeptide repeat
A16R_RS16785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A16R_RS16815	COG0534	Mate efflux family protein
A16R_RS16835	COG2184	nucleotidyltransferase activity
A16R_RS16840	COG2814	Major facilitator Superfamily
A16R_RS16845	COG1309	transcriptional regulator
A16R_RS16860	COG0814	amino acid
A16R_RS16865	COG1760	l-serine dehydratase
A16R_RS16870	COG1760	l-serine dehydratase
A16R_RS16885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A16R_RS16890	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A16R_RS16900	COG1335	isochorismatase
A16R_RS16905	COG1522	sequence-specific DNA binding
A16R_RS16910	COG0531	amino acid
A16R_RS16930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A16R_RS16950	COG1595	DNA-templated transcription, initiation
A16R_RS16965	COG0662	Cupin 2, conserved barrel domain protein
A16R_RS16975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16R_RS16975	COG2207	Transcriptional regulator
A16R_RS17030	COG0477	Major facilitator Superfamily
A16R_RS17040	COG1846	Transcriptional regulator
A16R_RS17045	COG2814	Major facilitator Superfamily
A16R_RS17060	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A16R_RS17065	COG1131	(ABC) transporter
A16R_RS17085	COG2076	Multidrug Resistance protein
A16R_RS17090	COG1309	transcriptional regulator
A16R_RS17100	COG2031	fatty acid transporter
A16R_RS17110	COG2249	NAD(P)H dehydrogenase (quinone) activity
A16R_RS17140	COG1122	ATPase activity
A16R_RS17145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A16R_RS17160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A16R_RS17165	COG1288	antiporter activity
A16R_RS17170	COG2356	endonuclease I
A16R_RS17185	COG3620	sequence-specific DNA binding
A16R_RS17190	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A16R_RS17195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A16R_RS17200	COG0124	histidyl-tRNA synthetase
A16R_RS17215	COG1733	regulation of RNA biosynthetic process
A16R_RS17220	COG0778	Nitroreductase
A16R_RS17245	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS17255	COG1131	(ABC) transporter
A16R_RS17280	COG1011	Hydrolase
A16R_RS17290	COG2365	Tyrosine phosphatase family
A16R_RS17315	COG0346	lactoylglutathione lyase activity
A16R_RS17320	COG1940	carbohydrate kinase activity
A16R_RS17325	COG0738	Major facilitator superfamily
A16R_RS17330	COG0110	maltose O-acetyltransferase activity
A16R_RS17345	COG1136	(ABC) transporter
A16R_RS17345	COG0577	efflux transmembrane transporter activity
A16R_RS17360	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A16R_RS17365	COG0628	permease
A16R_RS17385	COG2226	methyltransferase
A16R_RS17395	COG0477	Major facilitator Superfamily
A16R_RS17425	COG1253	flavin adenine dinucleotide binding
A16R_RS17430	COG0789	Transcriptional regulator
A16R_RS17435	COG0697	spore germination
A16R_RS17440	COG1357	PFAM Pentapeptide repeats (8 copies)
A16R_RS17445	COG3813	Protein conserved in bacteria
A16R_RS17455	COG2706	6-phosphogluconolactonase activity
A16R_RS17460	COG1070	Carbohydrate kinase
A16R_RS17470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A16R_RS17475	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A16R_RS17485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A16R_RS17490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A16R_RS17495	COG0604	alcohol dehydrogenase
A16R_RS17500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A16R_RS17510	COG0604	alcohol dehydrogenase
A16R_RS17510	COG3321	synthase
A16R_RS17520	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS17545	COG0656	L-ascorbic acid biosynthetic process
A16R_RS17550	COG2814	Major facilitator Superfamily
A16R_RS17570	COG0346	lactoylglutathione lyase activity
A16R_RS17575	COG0814	amino acid
A16R_RS17600	COG1393	Belongs to the ArsC family
A16R_RS17610	COG1733	regulation of RNA biosynthetic process
A16R_RS17615	COG2188	Transcriptional regulator
A16R_RS17625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A16R_RS17630	COG1733	regulation of RNA biosynthetic process
A16R_RS17635	COG1733	regulation of RNA biosynthetic process
A16R_RS17650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16R_RS17670	COG0384	phenazine biosynthesis protein PhzF
A16R_RS17680	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS17690	COG0318	PFAM AMP-dependent synthetase and ligase
A16R_RS17700	COG1733	regulation of RNA biosynthetic process
A16R_RS17735	COG1191	sigma factor activity
A16R_RS17750	COG1309	transcriptional regulator
A16R_RS17770	COG3152	Membrane
A16R_RS17800	COG1151	hydroxylamine reductase activity
A16R_RS17815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16R_RS17820	COG3409	Peptidoglycan-binding domain 1 protein
A16R_RS17820	COG3757	hydrolase, family 25
A16R_RS17855	COG2072	flavoprotein involved in K transport
A16R_RS17895	COG1113	amino acid transport
A16R_RS17900	COG2814	Major facilitator Superfamily
A16R_RS17935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A16R_RS17940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A16R_RS17970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16R_RS17975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16R_RS17980	COG3739	integral membrane protein
A16R_RS17985	COG0384	phenazine biosynthesis protein PhzF
A16R_RS18015	COG0583	DNA-binding transcription factor activity
A16R_RS18035	COG1193	negative regulation of DNA recombination
A16R_RS18055	COG1164	Oligoendopeptidase f
A16R_RS18060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A16R_RS18090	COG0584	glycerophosphoryl diester phosphodiesterase
A16R_RS18115	COG0640	Transcriptional regulator
A16R_RS18120	COG0604	alcohol dehydrogenase
A16R_RS18140	COG2808	Putative FMN-binding domain
A16R_RS18145	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A16R_RS18155	COG0385	Bile acid
A16R_RS18160	COG0277	FAD linked oxidase domain protein
A16R_RS18200	COG1216	Glycosyl transferase, family 2
A16R_RS18205	COG1024	Enoyl-CoA hydratase
A16R_RS18215	COG1285	pathogenesis
A16R_RS18230	COG2514	catechol 2,3-dioxygenase activity
A16R_RS18235	COG2720	vancomycin resistance protein
A16R_RS18275	COG0716	FMN binding
A16R_RS18305	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS18315	COG0165	Argininosuccinate lyase
A16R_RS18330	COG4145	pantothenate transmembrane transporter activity
A16R_RS18340	COG1012	belongs to the aldehyde dehydrogenase family
A16R_RS18345	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS18355	COG1657	PFAM Prenyltransferase squalene oxidase
A16R_RS18360	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A16R_RS18365	COG2962	Rard protein
A16R_RS18370	COG3326	Membrane
A16R_RS18385	COG0489	protein tyrosine kinase activity
A16R_RS18395	COG0314	molybdopterin synthase activity
A16R_RS18400	COG0303	'Molybdopterin
A16R_RS18405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16R_RS18410	COG2116	formate transmembrane transporter activity
A16R_RS18425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A16R_RS18430	COG5609	conserved protein (DUF2294)
A16R_RS18435	COG2427	Protein of unknown function (DUF1641)
A16R_RS18440	COG3383	formate dehydrogenase (NAD+) activity
A16R_RS18450	COG0697	spore germination
A16R_RS18490	COG2226	methyltransferase
A16R_RS18495	COG4166	transmembrane transport
A16R_RS18500	COG4166	transmembrane transport
A16R_RS18505	COG4166	transmembrane transport
A16R_RS18510	COG1301	dicarboxylic acid transport
A16R_RS18515	COG1316	TRANSCRIPTIONal
A16R_RS18525	COG1595	DNA-templated transcription, initiation
A16R_RS18545	COG1131	(ABC) transporter
A16R_RS18555	COG0673	inositol 2-dehydrogenase activity
A16R_RS18560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A16R_RS18565	COG0187	DNA topoisomerase II activity
A16R_RS18575	COG1832	CoA-binding protein
A16R_RS18580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A16R_RS18585	COG0745	RESPONSE REGULATOR receiver
A16R_RS18600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A16R_RS18605	COG4841	protein insertion into membrane
A16R_RS18610	COG0824	Thioesterase
A16R_RS18645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16R_RS18655	COG2274	protein secretion by the type I secretion system
A16R_RS18660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A16R_RS18700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A16R_RS18715	COG0183	Belongs to the thiolase family
A16R_RS18720	COG0318	PFAM AMP-dependent synthetase and ligase
A16R_RS18725	COG1268	BioY protein
A16R_RS18730	COG0318	PFAM AMP-dependent synthetase and ligase
A16R_RS18785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16R_RS18800	COG5002	protein histidine kinase activity
A16R_RS18805	COG0400	carboxylic ester hydrolase activity
A16R_RS18810	COG0346	lactoylglutathione lyase activity
A16R_RS18815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A16R_RS18820	COG0069	glutamate synthase activity
A16R_RS18825	COG1902	pentaerythritol trinitrate reductase activity
A16R_RS18830	COG1329	Transcriptional regulator
A16R_RS18835	COG0010	Belongs to the arginase family
A16R_RS18860	COG2226	methyltransferase
A16R_RS18920	COG4846	Membrane protein involved in cytochrome C biogenesis
A16R_RS18925	COG0785	Cytochrome C biogenesis protein
A16R_RS18940	COG0583	DNA-binding transcription factor activity
A16R_RS18945	COG1380	Effector of murein hydrolase LrgA
A16R_RS18950	COG1346	cytolysis
A16R_RS18975	COG5632	N-Acetylmuramoyl-L-alanine amidase
A16R_RS18975	COG3409	Peptidoglycan-binding domain 1 protein
A16R_RS18990	COG1132	(ABC) transporter
A16R_RS18995	COG1132	(ABC) transporter
A16R_RS19035	COG3639	organic phosphonate transmembrane transporter activity
A16R_RS19040	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A16R_RS19060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A16R_RS19080	COG1695	Transcriptional regulator
A16R_RS19125	COG3409	Peptidoglycan-binding domain 1 protein
A16R_RS19125	COG1388	LysM domain
A16R_RS19125	COG5632	N-Acetylmuramoyl-L-alanine amidase
A16R_RS19130	COG4824	toxin secretion phage lysis holin
A16R_RS19290	COG1595	DNA-templated transcription, initiation
A16R_RS19335	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A16R_RS19425	COG1396	sequence-specific DNA binding
A16R_RS19450	COG0174	glutamine synthetase
A16R_RS19455	COG0789	Transcriptional regulator
A16R_RS19460	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A16R_RS19470	COG2860	membrane
A16R_RS19480	COG0464	growth
A16R_RS19510	COG3584	3D domain protein
A16R_RS19510	COG1388	LysM domain
A16R_RS19520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A16R_RS19520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A16R_RS19520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A16R_RS19525	COG1105	Belongs to the carbohydrate kinase PfkB family
A16R_RS19530	COG1349	DNA-binding transcription factor activity
A16R_RS19540	COG2322	membrane
A16R_RS19555	COG1113	amino acid transport
A16R_RS19575	COG1408	metallophosphoesterase
A16R_RS19580	COG2116	formate transmembrane transporter activity
A16R_RS19595	COG2217	Heavy metal translocating P-type atpase
A16R_RS19600	COG2608	mercury ion transmembrane transporter activity
A16R_RS19605	COG1937	Protein conserved in bacteria
A16R_RS19615	COG2819	hydrolase of the alpha beta superfamily
A16R_RS19620	COG1120	ATPase activity
A16R_RS19625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16R_RS19630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16R_RS19640	COG0708	Exodeoxyribonuclease III
A16R_RS19645	COG2169	Transcriptional regulator
A16R_RS19650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A16R_RS19655	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A16R_RS19665	COG2364	Membrane
A16R_RS19680	COG2267	carboxylic ester hydrolase activity
A16R_RS19685	COG0346	lactoylglutathione lyase activity
A16R_RS19690	COG3300	MHYT domain
A16R_RS19690	COG5001	Diguanylate cyclase
A16R_RS19710	COG1346	cytolysis
A16R_RS19715	COG1380	Effector of murein hydrolase LrgA
A16R_RS19720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A16R_RS19725	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16R_RS19725	COG0596	Alpha beta hydrolase
A16R_RS19730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A16R_RS19750	COG1404	Belongs to the peptidase S8 family
A16R_RS19755	COG3773	Cell wall hydrolase
A16R_RS19760	COG0562	UDP-galactopyranose mutase
A16R_RS19765	COG1368	sulfuric ester hydrolase activity
A16R_RS19770	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A16R_RS19780	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A16R_RS19805	COG1131	(ABC) transporter
A16R_RS19825	COG4550	Control of competence regulator ComK, YlbF/YmcA
A16R_RS19830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A16R_RS19835	COG1013	pyruvate-flavodoxin oxidoreductase activity
A16R_RS19840	COG0674	pyruvate-flavodoxin oxidoreductase activity
A16R_RS19840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A16R_RS19850	COG2359	stage V sporulation protein S
A16R_RS19855	COG1692	metallophosphoesterase
A16R_RS19880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A16R_RS19885	COG1426	Protein conserved in bacteria
A16R_RS19900	COG0300	oxidoreductase activity
A16R_RS19905	COG0612	Peptidase, M16
A16R_RS19910	COG0612	Peptidase, M16
A16R_RS19915	COG1079	Belongs to the binding-protein-dependent transport system permease family
A16R_RS19925	COG3845	ABC transporter
A16R_RS19930	COG1744	ABC transporter substrate-binding protein PnrA-like
A16R_RS19935	COG2188	Transcriptional regulator
A16R_RS19940	COG1674	ftsk spoiiie
A16R_RS19950	COG0740	serine-type endopeptidase activity
A16R_RS19955	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A16R_RS19970	COG0527	aspartate kinase activity
A16R_RS19975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A16R_RS19980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A16R_RS19985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A16R_RS19995	COG1873	PFAM PRC-barrel domain
A16R_RS20000	COG0612	Peptidase, M16
A16R_RS20005	COG0726	polysaccharide deacetylase
A16R_RS20020	COG0196	riboflavin kinase activity
A16R_RS20025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A16R_RS20035	COG1550	Protein conserved in bacteria
A16R_RS20045	COG1358	cellular component organization or biogenesis
A16R_RS20050	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A16R_RS20055	COG0195	Participates in both transcription termination and antitermination
A16R_RS20080	COG0750	zinc metalloprotease
A16R_RS20090	COG4589	Belongs to the CDS family
A16R_RS20095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A16R_RS20105	COG0528	UMP kinase activity
A16R_RS20135	COG4974	Belongs to the 'phage' integrase family
A16R_RS20145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A16R_RS20155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A16R_RS20195	COG1837	Belongs to the UPF0109 family
A16R_RS20205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A16R_RS20215	COG0552	protein localization to endoplasmic reticulum
A16R_RS20220	COG1196	nuclear chromosome segregation
A16R_RS20230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A16R_RS20235	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS20240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A16R_RS20255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A16R_RS20260	COG1461	Dihydroxyacetone kinase
A16R_RS20265	COG1302	Protein conserved in bacteria
A16R_RS20280	COG1564	THIamine pyrophosphokinase
A16R_RS20285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A16R_RS20290	COG1162	GTPase activity
A16R_RS20295	COG0515	serine threonine protein kinase
A16R_RS20295	COG2815	serine threonine protein kinase
A16R_RS20300	COG0631	protein serine/threonine phosphatase activity
A16R_RS20310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A16R_RS20310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A16R_RS20320	COG0242	peptide deformylase activity
A16R_RS20325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A16R_RS20330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A16R_RS20350	COG1561	YicC-like family, N-terminal region
A16R_RS20355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A16R_RS20365	COG0006	proline dipeptidase activity
A16R_RS20385	COG3069	C4-dicarboxylate transmembrane transporter activity
A16R_RS20450	COG0564	pseudouridine synthase activity
A16R_RS20470	COG3599	regulation of cell shape
A16R_RS20475	COG2302	S4 RNA-binding domain
A16R_RS20480	COG0762	integral membrane protein
A16R_RS20490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A16R_RS20495	COG1496	oxidoreductase activity
A16R_RS20500	COG1873	PFAM PRC-barrel domain
A16R_RS20505	COG1191	sigma factor activity
A16R_RS20510	COG1191	sigma factor activity
A16R_RS20520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A16R_RS20525	COG0849	cell division
A16R_RS20530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A16R_RS20535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A16R_RS20545	COG0772	Belongs to the SEDS family
A16R_RS20560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A16R_RS20565	COG0768	penicillin binding
A16R_RS20570	COG0768	penicillin binding
A16R_RS20575	COG4839	cell division protein FtsL
A16R_RS20590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A16R_RS20605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A16R_RS20610	COG1399	metal-binding, possibly nucleic acid-binding protein
A16R_RS20660	COG4824	toxin secretion phage lysis holin
A16R_RS20750	COG1802	Transcriptional regulator
A16R_RS20750	COG4626	Terminase
A16R_RS20775	COG0582	viral genome integration into host DNA
A16R_RS20850	COG0756	dUTP diphosphatase activity
A16R_RS20865	COG1191	sigma factor activity
A16R_RS20890	COG1484	DNA-dependent DNA replication
A16R_RS20920	COG1396	sequence-specific DNA binding
A16R_RS20940	COG1396	sequence-specific DNA binding
A16R_RS20960	COG0582	viral genome integration into host DNA
A16R_RS20970	COG3480	Lon protease (S16) C-terminal proteolytic domain
A16R_RS20975	COG1752	Esterase of the alpha-beta hydrolase superfamily
A16R_RS20980	COG3314	Sporulation integral membrane protein YlbJ
A16R_RS20990	COG0742	ribosomal rna small subunit methyltransferase
A16R_RS21005	COG3679	Belongs to the UPF0342 family
A16R_RS21010	COG0406	alpha-ribazole phosphatase activity
A16R_RS21025	COG2340	Cysteine-rich secretory protein family
A16R_RS21040	COG3336	cytochrome c oxidase
A16R_RS21075	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A16R_RS21085	COG0772	Belongs to the SEDS family
A16R_RS21095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A16R_RS21100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A16R_RS21110	COG4896	Protein conserved in bacteria
A16R_RS21125	COG1217	gtp-binding protein TYPA
A16R_RS21135	COG0483	inositol monophosphate 1-phosphatase activity
A16R_RS21155	COG1982	Orn Lys Arg decarboxylase major
A16R_RS21200	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16R_RS21205	COG0022	dehydrogenase e1 component
A16R_RS21210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A16R_RS21220	COG0242	peptide deformylase activity
A16R_RS21225	COG0561	phosphatase activity
A16R_RS21240	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A16R_RS21245	COG0569	domain protein
A16R_RS21265	COG0583	DNA-binding transcription factor activity
A16R_RS21270	COG0517	IMP dehydrogenase activity
A16R_RS21280	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A16R_RS21290	COG4703	Protein of unknown function (DUF1797)
A16R_RS21305	COG2200	EAL domain
A16R_RS21310	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS21315	COG1408	metallophosphoesterase
A16R_RS21330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A16R_RS21370	COG2814	Major facilitator Superfamily
A16R_RS21390	COG3209	COG3209 Rhs family protein
A16R_RS21405	COG2205	protein histidine kinase activity
A16R_RS21415	COG0436	Aminotransferase
A16R_RS21420	COG1609	Transcriptional regulator
A16R_RS21425	COG3833	ABC-type maltose transport systems, permease component
A16R_RS21430	COG1175	transmembrane transport
A16R_RS21435	COG2182	Extracellular solute-binding protein
A16R_RS21445	COG0366	Alpha amylase catalytic
A16R_RS21450	COG3842	ATPase activity
A16R_RS21490	COG0183	Belongs to the thiolase family
A16R_RS21530	COG1695	Transcriptional regulator
A16R_RS21535	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS21545	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A16R_RS21555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A16R_RS21560	COG0436	Aminotransferase
A16R_RS21580	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A16R_RS21605	COG2199	diguanylate cyclase activity
A16R_RS21610	COG0778	Nitroreductase
A16R_RS21635	COG1263	PTS System
A16R_RS21635	COG2190	(PTS) system
A16R_RS21635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A16R_RS21640	COG3711	transcriptional antiterminator
A16R_RS21650	COG2188	Transcriptional regulator
A16R_RS21660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A16R_RS21690	COG1547	Domain of unknown function (DUF309)
A16R_RS21695	COG0456	acetyltransferase
A16R_RS21705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A16R_RS21710	COG4086	secreted protein
A16R_RS21715	COG0561	phosphatase activity
A16R_RS21720	COG0697	spore germination
A16R_RS21735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16R_RS21760	COG0733	neurotransmitter:sodium symporter activity
A16R_RS21780	COG1686	Belongs to the peptidase S11 family
A16R_RS21790	COG1725	Transcriptional regulator
A16R_RS21795	COG1131	(ABC) transporter
A16R_RS21815	COG1846	Transcriptional regulator
A16R_RS21830	COG0598	Magnesium transport protein CorA
A16R_RS21855	COG4974	Belongs to the 'phage' integrase family
A16R_RS21865	COG0735	belongs to the Fur family
A16R_RS21870	COG1300	Membrane
A16R_RS21890	COG0667	Aldo Keto reductase
A16R_RS21895	COG0656	L-ascorbic acid biosynthetic process
A16R_RS21900	COG0456	acetyltransferase
A16R_RS21900	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A16R_RS21910	COG0737	Belongs to the 5'-nucleotidase family
A16R_RS21910	COG4085	toxin activity
A16R_RS21910	COG1525	nuclease
A16R_RS21920	COG0596	Alpha beta hydrolase
A16R_RS21925	COG2056	Na+-H+ antiporter family
A16R_RS21930	COG1609	Transcriptional regulator
A16R_RS21935	COG0456	acetyltransferase
A16R_RS21940	COG1073	alpha beta
A16R_RS21955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A16R_RS21955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A16R_RS21960	COG0307	riboflavin synthase, alpha
A16R_RS21985	COG4106	trans-aconitate 2-methyltransferase activity
A16R_RS21990	COG2226	methyltransferase
A16R_RS21990	COG1073	alpha beta
A16R_RS22005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A16R_RS22020	COG1757	Na H antiporter
A16R_RS22025	COG0737	Belongs to the 5'-nucleotidase family
A16R_RS22035	COG1522	sequence-specific DNA binding
A16R_RS22055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A16R_RS22065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A16R_RS22080	COG0300	oxidoreductase activity
A16R_RS22090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16R_RS22095	COG1760	l-serine dehydratase
A16R_RS22100	COG1760	l-serine dehydratase
A16R_RS22125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A16R_RS22135	COG2195	Cleaves the N-terminal amino acid of tripeptides
A16R_RS22140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16R_RS22155	COG1376	ErfK ybiS ycfS ynhG family protein
A16R_RS22160	COG4129	membrane
A16R_RS22165	COG1126	abc transporter atp-binding protein
A16R_RS22170	COG0765	amino acid transport
A16R_RS22175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A16R_RS22195	COG2816	NAD+ diphosphatase activity
A16R_RS22200	COG0772	Belongs to the SEDS family
A16R_RS22210	COG0508	dehydrogenase complex catalyzes the overall conversion of
A16R_RS22215	COG0022	dehydrogenase e1 component
A16R_RS22220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A16R_RS22225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A16R_RS22240	COG0280	phosphate acetyltransferase
A16R_RS22260	COG0584	glycerophosphoryl diester phosphodiesterase
A16R_RS22265	COG3093	addiction module antidote protein HigA
A16R_RS22275	COG0745	RESPONSE REGULATOR receiver
A16R_RS22285	COG0750	zinc metalloprotease
A16R_RS22290	COG0497	DNA recombination
A16R_RS22300	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A16R_RS22310	COG0142	geranyltranstransferase activity
A16R_RS22335	COG1302	Protein conserved in bacteria
A16R_RS22340	COG0439	Biotin carboxylase
A16R_RS22345	COG0511	ligase activity, forming carbon-carbon bonds
A16R_RS22390	COG3854	ATPases associated with a variety of cellular activities
A16R_RS22415	COG0006	proline dipeptidase activity
A16R_RS22430	COG3872	metal-dependent enzyme
A16R_RS22440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A16R_RS22460	COG0095	Lipoate-protein ligase
A16R_RS22465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16R_RS22470	COG1609	Transcriptional regulator
A16R_RS22480	COG2076	Multidrug Resistance protein
A16R_RS22485	COG2076	Multidrug Resistance protein
A16R_RS22530	COG1131	(ABC) transporter
A16R_RS22535	COG1725	Transcriptional regulator
A16R_RS22570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A16R_RS22630	COG4970	Tfp pilus assembly protein FimT
A16R_RS22640	COG1459	type II secretion system
A16R_RS22645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A16R_RS22695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A16R_RS22700	COG1410	methionine synthase
A16R_RS22700	COG0646	methionine synthase
A16R_RS22705	COG0646	methionine synthase
A16R_RS22705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A16R_RS22710	COG0626	cystathionine gamma-synthase activity
A16R_RS22715	COG0626	cystathionine gamma-synthase activity
A16R_RS22735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16R_RS22745	COG1940	carbohydrate kinase activity
A16R_RS22750	COG4483	Protein conserved in bacteria
A16R_RS22755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A16R_RS22760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A16R_RS22765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A16R_RS22770	COG0704	Plays a role in the regulation of phosphate uptake
A16R_RS22780	COG0581	inorganic phosphate transmembrane transporter activity
A16R_RS22785	COG0573	inorganic phosphate transmembrane transporter activity
A16R_RS22790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A16R_RS22795	COG0768	penicillin binding
A16R_RS22800	COG0477	Major facilitator Superfamily
A16R_RS22805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A16R_RS22830	COG0735	belongs to the Fur family
A16R_RS22835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A16R_RS22840	COG1121	(ABC) transporter
A16R_RS22845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16R_RS22875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A16R_RS22880	COG2384	SAM-dependent methyltransferase
A16R_RS22885	COG2010	Cytochrome c
A16R_RS22890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A16R_RS22895	COG0358	DNA primase activity
A16R_RS22915	COG0517	IMP dehydrogenase activity
A16R_RS22930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A16R_RS22935	COG0295	cytidine deaminase activity
A16R_RS22940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A16R_RS22950	COG1480	7TM receptor with intracellular HD hydrolase
A16R_RS22955	COG1702	phosphate starvation-inducible protein PhoH
A16R_RS22975	COG1610	YqeY-like protein
A16R_RS22980	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A16R_RS22990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A16R_RS22995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A16R_RS23025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A16R_RS23030	COG1733	regulation of RNA biosynthetic process
A16R_RS23055	COG1466	dna polymerase III delta subunit
A16R_RS23065	COG2333	competence protein COMEC
A16R_RS23065	COG0658	competence protein
A16R_RS23070	COG2131	deaminase
A16R_RS23075	COG1555	photosystem II stabilization
A16R_RS23075	COG1596	polysaccharide export
A16R_RS23080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A16R_RS23085	COG2226	methyltransferase
A16R_RS23090	COG0799	negative regulation of ribosome biogenesis
A16R_RS23095	COG1713	HD superfamily hydrolase involved in NAD metabolism
A16R_RS23105	COG1534	Rna-binding protein
A16R_RS23115	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A16R_RS23120	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A16R_RS23150	COG1595	DNA-templated transcription, initiation
A16R_RS23160	COG0778	Nitroreductase
A16R_RS23165	COG2357	RelA SpoT domain protein
A16R_RS23175	COG1785	Belongs to the alkaline phosphatase family
A16R_RS23185	COG2267	carboxylic ester hydrolase activity
A16R_RS23220	COG1404	Belongs to the peptidase S8 family
A16R_RS23225	COG3186	Phenylalanine-4-hydroxylase
A16R_RS23240	COG2259	Doxx family
A16R_RS23280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16R_RS23290	COG1012	belongs to the aldehyde dehydrogenase family
A16R_RS23290	COG1454	alcohol dehydrogenase
A16R_RS23295	COG0626	cystathionine gamma-synthase activity
A16R_RS23300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A16R_RS23325	COG0768	penicillin binding
A16R_RS23340	COG0826	peptidase U32
A16R_RS23345	COG0826	peptidase U32
A16R_RS23350	COG4122	O-methyltransferase activity
A16R_RS23355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A16R_RS23375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A16R_RS23385	COG0628	permease
A16R_RS23405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A16R_RS23415	COG0482	sulfurtransferase activity
A16R_RS23420	COG1104	cysteine desulfurase activity
A16R_RS23425	COG1959	2 iron, 2 sulfur cluster binding
A16R_RS23430	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A16R_RS23440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A16R_RS23470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A16R_RS23480	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A16R_RS23480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A16R_RS23485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A16R_RS23490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A16R_RS23490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A16R_RS23500	COG2244	polysaccharide biosynthetic process
A16R_RS23505	COG2323	membrane
A16R_RS23515	COG1862	Preprotein translocase
A16R_RS23545	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A16R_RS23555	COG0697	spore germination
A16R_RS23560	COG0697	spore germination
A16R_RS23565	COG0640	Transcriptional regulator
A16R_RS23590	COG0157	Belongs to the NadC ModD family
A16R_RS23595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A16R_RS23600	COG1104	cysteine desulfurase activity
A16R_RS23605	COG1827	regulation of RNA biosynthetic process
A16R_RS23610	COG2258	MOSC domain
A16R_RS23615	COG0077	Prephenate dehydratase
A16R_RS23620	COG0577	efflux transmembrane transporter activity
A16R_RS23625	COG0577	efflux transmembrane transporter activity
A16R_RS23630	COG1136	(ABC) transporter
A16R_RS23640	COG0745	RESPONSE REGULATOR receiver
A16R_RS23645	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A16R_RS23650	COG3290	protein histidine kinase activity
A16R_RS23660	COG2868	ribosomal protein
A16R_RS23670	COG1530	ribonuclease E activity
A16R_RS23675	COG1994	Peptidase M50
A16R_RS23680	COG0739	heme binding
A16R_RS23685	COG2894	cell division
A16R_RS23705	COG1077	Cell shape determining protein MreB Mrl
A16R_RS23730	COG0285	dihydrofolate synthase activity
A16R_RS23735	COG0525	valine-tRNA ligase activity
A16R_RS23745	COG1388	LysM domain
A16R_RS23755	COG0113	porphobilinogen synthase activity
A16R_RS23760	COG1587	Uroporphyrinogen-III synthase
A16R_RS23770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A16R_RS23780	COG1846	Transcriptional regulator
A16R_RS23785	COG1764	response to oxidative stress
A16R_RS23800	COG1067	ATP-dependent peptidase activity
A16R_RS23800	COG0470	DNA polymerase III
A16R_RS23855	COG0622	Phosphoesterase
A16R_RS23870	COG5401	PFAM Sporulation and spore germination
A16R_RS23890	COG1309	transcriptional regulator
A16R_RS23905	COG2197	response regulator
A16R_RS23910	COG2233	PERMEase
A16R_RS23920	COG0402	S-adenosylhomocysteine deaminase activity
A16R_RS23925	COG0402	S-adenosylhomocysteine deaminase activity
A16R_RS23935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A16R_RS23945	COG0444	Belongs to the ABC transporter superfamily
A16R_RS23950	COG4608	Belongs to the ABC transporter superfamily
A16R_RS23960	COG3279	Response regulator of the LytR AlgR family
A16R_RS23975	COG1983	PspC domain protein
A16R_RS23980	COG1396	sequence-specific DNA binding
A16R_RS23985	COG0697	spore germination
A16R_RS23995	COG1959	2 iron, 2 sulfur cluster binding
A16R_RS24000	COG1668	transmembrane transport
A16R_RS24005	COG4152	abc transporter atp-binding protein
A16R_RS24010	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A16R_RS24020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A16R_RS24025	COG1876	peptidase activity
A16R_RS24030	COG0824	Thioesterase
A16R_RS24035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A16R_RS24040	COG1053	succinate dehydrogenase
A16R_RS24045	COG2009	succinate dehydrogenase
A16R_RS24050	COG1719	4-vinyl reductase, 4VR
A16R_RS24060	COG3118	belongs to the thioredoxin family
A16R_RS24065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A16R_RS24070	COG2086	electron transfer activity
A16R_RS24075	COG1024	Enoyl-CoA hydratase
A16R_RS24080	COG1309	transcriptional regulator
A16R_RS24085	COG0318	PFAM AMP-dependent synthetase and ligase
A16R_RS24110	COG2318	DinB family
A16R_RS24140	COG1131	(ABC) transporter
A16R_RS24145	COG2205	protein histidine kinase activity
A16R_RS24150	COG0745	RESPONSE REGULATOR receiver
A16R_RS24160	COG4895	conserved protein (DUF2196)
A16R_RS24165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A16R_RS24180	COG4509	Sortase family
A16R_RS24185	COG1120	ATPase activity
A16R_RS24200	COG5386	Cell surface protein
A16R_RS24210	COG5386	Cell surface protein
A16R_RS24215	COG1114	Component of the transport system for branched-chain amino acids
A16R_RS24220	COG1187	pseudouridine synthase activity
A16R_RS24235	COG1796	DNA polymerase
A16R_RS24235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A16R_RS24240	COG1286	toxin biosynthetic process
A16R_RS24285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A16R_RS24295	COG1418	mRNA catabolic process
A16R_RS24320	COG2814	Major facilitator Superfamily
A16R_RS24325	COG1566	PFAM secretion protein HlyD family protein
A16R_RS24330	COG1309	transcriptional regulator
A16R_RS24335	COG1363	Peptidase, m42
A16R_RS24360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A16R_RS24370	COG1484	DNA-dependent DNA replication
A16R_RS24375	COG3611	Membrane attachment protein
A16R_RS24385	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A16R_RS24395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A16R_RS24400	COG0237	dephospho-CoA kinase activity
A16R_RS24405	COG1971	Probably functions as a manganese efflux pump
A16R_RS24415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A16R_RS24415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A16R_RS24420	COG5002	protein histidine kinase activity
A16R_RS24425	COG0745	RESPONSE REGULATOR receiver
A16R_RS24450	COG0538	isocitrate dehydrogenase activity
A16R_RS24455	COG0372	Belongs to the citrate synthase family
A16R_RS24470	COG0628	permease
A16R_RS24475	COG3030	protein affecting phage T7 exclusion by the F plasmid
A16R_RS24500	COG1725	Transcriptional regulator
A16R_RS24505	COG0281	malic enzyme
A16R_RS24510	COG0587	DNA-directed DNA polymerase activity
A16R_RS24525	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A16R_RS24550	COG4109	DRTGG domain
A16R_RS24565	COG0006	proline dipeptidase activity
A16R_RS24605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16R_RS24610	COG0662	Cupin 2, conserved barrel domain protein
A16R_RS24620	COG1476	TRANSCRIPTIONal
A16R_RS24635	COG1028	Short-chain dehydrogenase reductase Sdr
A16R_RS24640	COG0589	response to stress
A16R_RS24690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16R_RS24710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A16R_RS24715	COG0827	DNA restriction-modification system
A16R_RS24720	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A16R_RS24725	COG3874	Sporulation protein YtfJ
A16R_RS24740	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A16R_RS24750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A16R_RS24765	COG1104	cysteine desulfurase activity
A16R_RS24775	COG0583	DNA-binding transcription factor activity
A16R_RS24780	COG0697	spore germination
A16R_RS24790	COG1956	GAF domain-containing protein
A16R_RS24795	COG0626	cystathionine gamma-synthase activity
A16R_RS24830	COG1595	DNA-templated transcription, initiation
A16R_RS24845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A16R_RS24850	COG0454	-acetyltransferase
A16R_RS24855	COG0517	IMP dehydrogenase activity
A16R_RS24860	COG0123	including yeast histone deacetylase and acetoin utilization protein
A16R_RS24870	COG0745	RESPONSE REGULATOR receiver
A16R_RS24880	COG0666	response to abiotic stimulus
A16R_RS24915	COG1609	Transcriptional regulator
A16R_RS24925	COG4851	CamS sex pheromone cAM373 precursor
A16R_RS24930	COG3118	belongs to the thioredoxin family
A16R_RS24940	COG2309	aminopeptidase activity
A16R_RS24960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16R_RS24975	COG1674	ftsk spoiiie
A16R_RS24985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A16R_RS24990	COG4848	Belongs to the UPF0354 family
A16R_RS24995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16R_RS25000	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A16R_RS25005	COG1363	Peptidase, m42
A16R_RS25015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16R_RS25030	COG0510	thiamine kinase activity
A16R_RS25035	COG1523	belongs to the glycosyl hydrolase 13 family
A16R_RS25055	COG1349	DNA-binding transcription factor activity
A16R_RS25060	COG1187	pseudouridine synthase activity
A16R_RS25065	COG2244	polysaccharide biosynthetic process
A16R_RS25070	COG2081	HI0933 family
A16R_RS25075	COG2814	Major facilitator Superfamily
A16R_RS25085	COG3832	glyoxalase III activity
A16R_RS25110	COG1329	Transcriptional regulator
A16R_RS25120	COG4975	Glucose uptake
A16R_RS25135	COG0314	molybdopterin synthase activity
A16R_RS25140	COG1763	Mo-molybdopterin cofactor biosynthetic process
A16R_RS25145	COG0303	'Molybdopterin
A16R_RS25155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A16R_RS25180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A16R_RS25190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A16R_RS25235	COG2814	Major facilitator Superfamily
A16R_RS25240	COG0475	glutathione-regulated potassium exporter activity
A16R_RS25245	COG0490	domain, Protein
A16R_RS25250	COG0582	viral genome integration into host DNA
A16R_RS25260	COG1136	(ABC) transporter
A16R_RS25280	COG1242	4 iron, 4 sulfur cluster binding
A16R_RS25285	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A16R_RS25295	COG1131	(ABC) transporter
A16R_RS25305	COG1794	racemase activity, acting on amino acids and derivatives
A16R_RS25330	COG2267	carboxylic ester hydrolase activity
A16R_RS25335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A16R_RS25340	COG0671	phosphoesterase, PA-phosphatase related
A16R_RS25345	COG0438	transferase activity, transferring glycosyl groups
A16R_RS25355	COG0521	Mo-molybdopterin cofactor biosynthetic process
A16R_RS25415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A16R_RS25420	COG5002	protein histidine kinase activity
A16R_RS25425	COG4191	Histidine kinase
A16R_RS25430	COG2267	carboxylic ester hydrolase activity
A16R_RS25435	COG1368	sulfuric ester hydrolase activity
A16R_RS25455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A16R_RS25460	COG1116	anion transmembrane transporter activity
A16R_RS25465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A16R_RS25490	COG0494	nUDIX hydrolase
A16R_RS25525	COG0288	reversible hydration of carbon dioxide
A16R_RS25530	COG1271	oxidase subunit
A16R_RS25535	COG1294	oxidase, subunit
A16R_RS25560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16R_RS25585	COG1842	Phage shock protein A
A16R_RS25620	COG5002	protein histidine kinase activity
A16R_RS25625	COG0745	RESPONSE REGULATOR receiver
A16R_RS25655	COG1597	lipid kinase activity
A16R_RS25695	COG0586	Pfam SNARE associated Golgi protein
A16R_RS25705	COG0577	efflux transmembrane transporter activity
A16R_RS25710	COG1136	(ABC) transporter
A16R_RS25715	COG3708	Transcriptional regulator
A16R_RS25715	COG2207	Transcriptional regulator
A16R_RS25720	COG0745	RESPONSE REGULATOR receiver
A16R_RS25725	COG2205	protein histidine kinase activity
A16R_RS25735	COG0577	efflux transmembrane transporter activity
A16R_RS25740	COG1136	(ABC) transporter
A16R_RS25760	COG2188	Transcriptional regulator
A16R_RS25780	COG3964	amidohydrolase
A16R_RS25810	COG4948	Mandelate Racemase Muconate Lactonizing
A16R_RS25820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A16R_RS25825	COG0596	Alpha beta hydrolase
A16R_RS25830	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A16R_RS25835	COG1169	isochorismate synthase
A16R_RS25840	COG1575	Belongs to the MenA family. Type 1 subfamily
A16R_RS25845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A16R_RS25870	COG0058	SHG alpha-glucan phosphorylase activity
A16R_RS25875	COG0297	glycogen (starch) synthase activity
A16R_RS25880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A16R_RS26010	COG0544	peptidyl-prolyl cis-trans isomerase activity
A16R_RS26055	COG1285	pathogenesis
A16R_RS26060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A16R_RS26070	COG0166	Belongs to the GPI family
A16R_RS26080	COG2155	Conserved Protein
A16R_RS26085	COG1098	S1 RNA binding domain
A16R_RS26090	COG0436	Aminotransferase
A16R_RS26095	COG1522	sequence-specific DNA binding
A16R_RS26100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A16R_RS26105	COG2267	carboxylic ester hydrolase activity
A16R_RS26115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A16R_RS26130	COG5018	Exonuclease
A16R_RS26135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A16R_RS26160	COG2050	protein possibly involved in aromatic compounds catabolism
A16R_RS26170	COG1268	BioY protein
A16R_RS26180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A16R_RS26185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A16R_RS26200	COG3584	3D domain protein
A16R_RS26215	COG1252	NADH dehydrogenase
A16R_RS26230	COG3708	Transcriptional regulator
A16R_RS26245	COG1683	Conserved Protein
A16R_RS26265	COG0316	Belongs to the HesB IscA family
A16R_RS26280	COG1252	NADH dehydrogenase
A16R_RS26295	COG0390	transport system, permease component
A16R_RS26300	COG2824	Alkylphosphonate utilization operon protein PhnA
A16R_RS26340	COG4837	Protein of unknown function (DUF1462)
A16R_RS26345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A16R_RS26360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A16R_RS26365	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A16R_RS26375	COG2249	NAD(P)H dehydrogenase (quinone) activity
A16R_RS26380	COG0647	UMP catabolic process
A16R_RS26390	COG2445	Protein of unknown function DUF86
A16R_RS26395	COG1494	fructose-1,6-bisphosphatase
A16R_RS26415	COG4470	Protein conserved in bacteria
A16R_RS26425	COG0789	Transcriptional regulator
A16R_RS26430	COG4377	Putative membrane peptidase family (DUF2324)
A16R_RS26455	COG0739	heme binding
A16R_RS26465	COG3377	Domain of unknown function (DUF1805)
A16R_RS26470	COG0737	Belongs to the 5'-nucleotidase family
A16R_RS26485	COG1695	Transcriptional regulator
A16R_RS26500	COG0719	Fe-S assembly protein
A16R_RS26505	COG0822	iron-sulfur transferase activity
A16R_RS26510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A16R_RS26515	COG0719	Fe-S assembly protein
A16R_RS26520	COG0396	ATPase activity
A16R_RS26525	COG1464	Belongs to the NlpA lipoprotein family
A16R_RS26530	COG1464	Belongs to the NlpA lipoprotein family
A16R_RS26535	COG2011	ABC-type metal ion transport system permease component
A16R_RS26540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A16R_RS26550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A16R_RS26555	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A16R_RS26575	COG1393	Belongs to the ArsC family
A16R_RS26630	COG0039	L-malate dehydrogenase activity
A16R_RS26655	COG1309	transcriptional regulator
A16R_RS26660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A16R_RS26665	COG1960	acyl-CoA dehydrogenase activity
A16R_RS26675	COG0183	Belongs to the thiolase family
A16R_RS26680	COG1024	Enoyl-CoA hydratase
A16R_RS26680	COG1250	3-hydroxyacyl-CoA dehydrogenase
A16R_RS26695	COG1686	Belongs to the peptidase S11 family
A16R_RS26710	COG0011	TIGRFAM Protein of
A16R_RS26715	COG0840	transmembrane signaling receptor activity
A16R_RS26735	COG2814	Major facilitator Superfamily
A16R_RS26740	COG0531	amino acid
A16R_RS26750	COG0706	membrane insertase activity
A16R_RS26760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A16R_RS26800	COG0586	Pfam SNARE associated Golgi protein
A16R_RS26810	COG1376	ErfK ybiS ycfS ynhG family protein
A16R_RS26815	COG0745	RESPONSE REGULATOR receiver
A16R_RS26820	COG5002	protein histidine kinase activity
A16R_RS26845	COG2151	metal-sulfur cluster biosynthetic enzyme
A16R_RS26850	COG3227	Zinc metalloprotease (Elastase)
A16R_RS26855	COG1741	Belongs to the pirin family
A16R_RS26870	COG0475	glutathione-regulated potassium exporter activity
A16R_RS26875	COG0490	domain, Protein
A16R_RS26885	COG1115	amino acid carrier protein
A16R_RS26890	COG0783	Belongs to the Dps family
A16R_RS26905	COG1611	Belongs to the LOG family
A16R_RS26925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16R_RS26930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16R_RS26935	COG1115	amino acid carrier protein
A16R_RS26940	COG1115	amino acid carrier protein
A16R_RS26945	COG2910	NAD(P)H-binding
A16R_RS26975	COG0656	L-ascorbic acid biosynthetic process
A16R_RS26980	COG2814	Major facilitator Superfamily
A16R_RS26985	COG1733	regulation of RNA biosynthetic process
A16R_RS26995	COG1252	NADH dehydrogenase
A16R_RS27000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A16R_RS27005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A16R_RS27015	COG3290	protein histidine kinase activity
A16R_RS27015	COG0840	transmembrane signaling receptor activity
A16R_RS27025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A16R_RS27030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A16R_RS27045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A16R_RS27110	COG0557	exoribonuclease II activity
A16R_RS27115	COG1647	Serine aminopeptidase, S33
A16R_RS27120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A16R_RS27125	COG1346	cytolysis
A16R_RS27235	COG4695	Portal protein
A16R_RS27260	COG4974	Belongs to the 'phage' integrase family
A16R_RS27270	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A16R_RS27275	COG0149	triose-phosphate isomerase activity
A16R_RS27285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A16R_RS27300	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A16R_RS27325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A16R_RS27340	COG2323	membrane
A16R_RS27345	COG0740	serine-type endopeptidase activity
A16R_RS27355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A16R_RS27365	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A16R_RS27375	COG1051	belongs to the nudix hydrolase family
A16R_RS27385	COG0492	ferredoxin-NADP+ reductase activity
A16R_RS27390	COG0457	Tetratricopeptide repeat
A16R_RS27395	COG0110	maltose O-acetyltransferase activity
A16R_RS27415	COG1950	PFAM Membrane protein of
A16R_RS27425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A16R_RS27430	COG0556	nucleotide-excision repair
A16R_RS27450	COG0789	Transcriptional regulator
A16R_RS27485	COG0583	DNA-binding transcription factor activity
A16R_RS27495	COG0655	NAD(P)H dehydrogenase (quinone) activity
A16R_RS27500	COG0488	(ABC) transporter
A16R_RS27510	COG1132	(ABC) transporter
A16R_RS27515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A16R_RS27520	COG0793	Belongs to the peptidase S41A family
A16R_RS27520	COG3409	Peptidoglycan-binding domain 1 protein
A16R_RS27525	COG2177	Part of the ABC transporter FtsEX involved in
A16R_RS27530	COG2884	Cell division ATP-binding protein ftsE
A16R_RS27550	COG0653	protein targeting
A16R_RS27555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A16R_RS27560	COG1278	Cold shock
A16R_RS27565	COG1040	competence protein
A16R_RS27570	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A16R_RS27575	COG1388	LysM domain
A16R_RS27575	COG0791	NLP P60 protein
A16R_RS27580	COG1733	regulation of RNA biosynthetic process
A16R_RS27590	COG1307	EDD domain protein, DegV family
A16R_RS27595	COG1739	Uncharacterized protein family UPF0029
A16R_RS27600	COG1316	TRANSCRIPTIONal
A16R_RS27605	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A16R_RS27610	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A16R_RS27615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A16R_RS27625	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A16R_RS27625	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A16R_RS27640	COG3394	polysaccharide catabolic process
A16R_RS27645	COG1486	melibiose metabolic process
A16R_RS27650	COG1447	Phosphotransferase system cellobiose-specific component IIA
A16R_RS27655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A16R_RS27665	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A16R_RS27670	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A16R_RS27675	COG1447	Phosphotransferase system cellobiose-specific component IIA
A16R_RS27685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A16R_RS27690	COG1301	dicarboxylic acid transport
A16R_RS27700	COG0346	lactoylglutathione lyase activity
A16R_RS27705	COG1511	domain protein
A16R_RS27710	COG0583	DNA-binding transcription factor activity
A16R_RS27715	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A16R_RS27735	COG1271	oxidase subunit
A16R_RS27740	COG1294	oxidase, subunit
A16R_RS27745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A16R_RS27755	COG1620	l-lactate permease
A16R_RS27765	COG2389	metal-binding protein
A16R_RS27780	COG1368	sulfuric ester hydrolase activity
A16R_RS27800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A16R_RS27820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A16R_RS27830	COG1388	LysM domain
A16R_RS27830	COG3584	3D domain protein
A16R_RS27855	COG4715	Zinc finger, swim domain protein
A16R_RS27860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A16R_RS27900	COG0577	efflux transmembrane transporter activity
A16R_RS27905	COG1136	(ABC) transporter
A16R_RS27940	COG5002	protein histidine kinase activity
A16R_RS27945	COG0745	RESPONSE REGULATOR receiver
A16R_RS27950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A16R_RS27970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A16R_RS27975	COG1134	teichoic acid transport
A16R_RS27980	COG1682	transport, permease protein
A16R_RS27985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A16R_RS28030	COG1609	Transcriptional regulator
A16R_RS28045	COG0739	heme binding
A16R_RS28065	COG2385	sporulation resulting in formation of a cellular spore
A16R_RS28080	COG4836	Membrane
A16R_RS28090	COG1007	ATP synthesis coupled electron transport
A16R_RS28095	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A16R_RS28100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A16R_RS28110	COG0839	Belongs to the complex I subunit 6 family
A16R_RS28125	COG0649	NAD binding
A16R_RS28130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A16R_RS28145	COG3300	MHYT domain
A16R_RS28145	COG5001	Diguanylate cyclase
A16R_RS28195	COG0356	it plays a direct role in the translocation of protons across the membrane
A16R_RS28230	COG0698	ribose 5-phosphate isomerase
A16R_RS28245	COG2190	(PTS) system
A16R_RS28250	COG2259	Doxx family
A16R_RS28255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A16R_RS28275	COG0009	L-threonylcarbamoyladenylate synthase
A16R_RS28290	COG2890	protein-(glutamine-N5) methyltransferase activity
A16R_RS28310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A16R_RS28315	COG1494	fructose-1,6-bisphosphatase
A16R_RS28340	COG4821	SIS domain
A16R_RS28350	COG3343	RNA polymerase activity
A16R_RS28360	COG1960	acyl-CoA dehydrogenase activity
A16R_RS28365	COG1960	acyl-CoA dehydrogenase activity
A16R_RS28370	COG1250	3-hydroxyacyl-CoA dehydrogenase
A16R_RS28375	COG0183	Belongs to the thiolase family
A16R_RS28380	COG2181	nitrate reductase activity
A16R_RS28380	COG0247	lactate metabolic process
A16R_RS28385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A16R_RS28395	COG5001	Diguanylate cyclase
A16R_RS28395	COG3300	MHYT domain
A16R_RS28415	COG2197	response regulator
A16R_RS28420	COG4585	Histidine kinase
A16R_RS28425	COG0842	Transport permease protein
A16R_RS28430	COG1131	(ABC) transporter
A16R_RS28435	COG0024	Methionine aminopeptidase
A16R_RS28455	COG2234	aminopeptidase activity
A16R_RS28475	COG1595	DNA-templated transcription, initiation
A16R_RS28480	COG0018	arginyl-trna synthetase
A16R_RS28485	COG4506	Protein conserved in bacteria
A16R_RS28490	COG1619	proteins homologs of microcin C7 resistance protein MccF
A16R_RS28510	COG0010	Belongs to the arginase family
A16R_RS28520	COG2814	Major facilitator Superfamily
A16R_RS28525	COG0789	Transcriptional regulator
A16R_RS28530	COG0584	glycerophosphoryl diester phosphodiesterase
A16R_RS28535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A16R_RS28550	COG1994	Peptidase M50
A16R_RS28560	COG1078	dGTPase activity
A16R_RS28565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A16R_RS28570	COG1120	ATPase activity
A16R_RS28575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A16R_RS28600	COG0095	Lipoate-protein ligase
A16R_RS28605	COG0280	phosphate acetyltransferase
A16R_RS28620	COG3773	Cell wall hydrolase
A16R_RS28630	COG2363	Small membrane protein
A16R_RS28645	COG2233	PERMEase
A16R_RS28650	COG0561	phosphatase activity
A16R_RS28655	COG2814	Major facilitator Superfamily
A16R_RS28665	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A16R_RS28670	COG1131	(ABC) transporter
A16R_RS28675	COG2755	lipolytic protein G-D-S-L family
A16R_RS28680	COG1609	Transcriptional regulator
A16R_RS28690	COG0460	homoserine dehydrogenase
A16R_RS28700	COG2873	o-acetylhomoserine
A16R_RS28710	COG1011	Hydrolase
A16R_RS28715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A16R_RS28725	COG2197	response regulator
A16R_RS28735	COG0351	phosphomethylpyrimidine kinase
A16R_RS28740	COG3706	GGDEF domain
A16R_RS28745	COG2879	small protein
A16R_RS28750	COG1966	Carbon starvation protein
A16R_RS28755	COG3279	Response regulator of the LytR AlgR family
A16R_RS28760	COG0477	Major facilitator Superfamily
A16R_RS28785	COG0840	transmembrane signaling receptor activity
A16R_RS28795	COG1607	acyl-coa hydrolase
A16R_RS28810	COG0488	(ABC) transporter
A16R_RS28840	COG0463	Glycosyl transferase, family 2
A16R_RS28845	COG1309	transcriptional regulator
A16R_RS28850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A16R_RS28855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A16R_RS28855	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A16R_RS28860	COG0628	permease
A16R_RS28875	COG3279	Response regulator of the LytR AlgR family
A16R_RS28880	COG3275	phosphorelay sensor kinase activity
A16R_RS28885	COG2814	Major facilitator Superfamily
A16R_RS28890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A16R_RS28895	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A16R_RS28905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A16R_RS28925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A16R_RS28930	COG1272	protein, Hemolysin III
A16R_RS28950	COG0516	GMP reductase activity
A16R_RS28955	COG1164	Oligoendopeptidase f
A16R_RS28975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A16R_RS28980	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A16R_RS28985	COG4853	Protein conserved in bacteria
A16R_RS28990	COG4863	YycH protein
A16R_RS28995	COG5002	protein histidine kinase activity
A16R_RS29000	COG0745	RESPONSE REGULATOR receiver
A16R_RS29030	COG0305	Participates in initiation and elongation during chromosome replication
A16R_RS29040	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A16R_RS29045	COG4241	membrane
A16R_RS29055	COG0629	single-stranded DNA binding
A16R_RS29065	COG0012	GTP binding
A16R_RS29070	COG4481	Protein conserved in bacteria
A16R_RS29075	COG0668	transmembrane transport
A16R_RS29085	COG1475	DNA binding
A16R_RS29090	COG1192	Involved in chromosome partitioning
A16R_RS29115	COG1847	R3H domain protein
A16R_RS29120	COG0706	membrane insertase activity
A16R_RS29130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A16R_RS29185	COG3344	reverse transcriptase
A16R_RS29280	COG3344	reverse transcriptase
A16R_RS29505	COG4962	Type ii secretion system protein e
A16R_RS29645	COG2311	Membrane
A16R_RS29665	COG4196	transglutaminase domain protein
A16R_RS29670	COG0671	phosphoesterase, PA-phosphatase related
A16R_RS29695	COG1215	transferase activity, transferring glycosyl groups
A16R_RS29700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A16R_RS29705	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A16R_RS29895	COG4974	Belongs to the 'phage' integrase family
A16R_RS29950	COG3443	Belongs to the bacterial solute-binding protein 9 family
A16R_RS29965	COG4974	Belongs to the 'phage' integrase family
A16R_RS29990	COG0457	Tetratricopeptide repeat