locus-tag	class	description
KM400_RS00010	COG0592	DNA-directed DNA polymerase activity
KM400_RS00015	COG2501	S4 domain
KM400_RS00025	COG0187	DNA topoisomerase II activity
KM400_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM400_RS00065	COG0516	GMP reductase activity
KM400_RS00065	COG0517	IMP dehydrogenase activity
KM400_RS00070	COG1686	Belongs to the peptidase S11 family
KM400_RS00100	COG1428	Deoxynucleoside kinase
KM400_RS00105	COG1428	Deoxynucleoside kinase
KM400_RS00110	COG1335	isochorismatase
KM400_RS00115	COG0590	tRNA wobble adenosine to inosine editing
KM400_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KM400_RS00180	COG1982	Orn Lys Arg decarboxylase major
KM400_RS00190	COG0470	DNA polymerase III
KM400_RS00195	COG1774	PSP1 C-terminal conserved region
KM400_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KM400_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KM400_RS00220	COG2002	toxin-antitoxin pair type II binding
KM400_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM400_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM400_RS00230	COG0084	hydrolase, TatD family'
KM400_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM400_RS00250	COG4466	Protein conserved in bacteria
KM400_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KM400_RS00270	COG0251	oxidation-reduction process
KM400_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KM400_RS00305	COG2002	toxin-antitoxin pair type II binding
KM400_RS00310	COG2244	polysaccharide biosynthetic process
KM400_RS00315	COG3956	TIGRFAM MazG family protein
KM400_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KM400_RS00340	COG1098	S1 RNA binding domain
KM400_RS00355	COG2208	phosphoserine phosphatase activity
KM400_RS00360	COG0037	tRNA processing
KM400_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM400_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM400_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM400_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KM400_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
KM400_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM400_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KM400_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KM400_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KM400_RS00420	COG1396	sequence-specific DNA binding
KM400_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM400_RS00455	COG3880	PFAM UvrB UvrC protein
KM400_RS00465	COG0542	response to heat
KM400_RS00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KM400_RS00480	COG4956	integral membrane protein (PIN domain superfamily)
KM400_RS00500	COG1045	serine acetyltransferase
KM400_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM400_RS00520	COG3688	RNA-binding protein containing a PIN domain
KM400_RS00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM400_RS00540	COG0250	Participates in transcription elongation, termination and antitermination
KM400_RS00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KM400_RS00565	COG2813	Specifically methylates the guanine in position
KM400_RS00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KM400_RS00580	COG1358	cellular component organization or biogenesis
KM400_RS00650	COG0255	Belongs to the universal ribosomal protein uL29 family
KM400_RS00710	COG0201	protein transport
KM400_RS00720	COG0024	Methionine aminopeptidase
KM400_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KM400_RS00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM400_RS00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM400_RS00795	COG0489	protein tyrosine kinase activity
KM400_RS00805	COG2194	sulfuric ester hydrolase activity
KM400_RS00810	COG0726	polysaccharide deacetylase
KM400_RS00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KM400_RS00895	COG4856	YbbR-like protein
KM400_RS00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM400_RS00915	COG0596	Alpha beta hydrolase
KM400_RS00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KM400_RS00940	COG4946	Tricorn protease homolog
KM400_RS00940	COG1506	peptidase
KM400_RS00940	COG0823	Involved in the tonB-independent uptake of proteins
KM400_RS00975	COG2011	ABC-type metal ion transport system permease component
KM400_RS00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM400_RS00985	COG1464	Belongs to the NlpA lipoprotein family
KM400_RS00990	COG0604	alcohol dehydrogenase
KM400_RS01005	COG2271	Major facilitator Superfamily
KM400_RS01015	COG2814	Major facilitator Superfamily
KM400_RS01030	COG0601	transmembrane transport
KM400_RS01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM400_RS01040	COG0444	Belongs to the ABC transporter superfamily
KM400_RS01045	COG4608	Belongs to the ABC transporter superfamily
KM400_RS01050	COG4166	transmembrane transport
KM400_RS01060	COG2207	Transcriptional regulator
KM400_RS01075	COG4166	transmembrane transport
KM400_RS01080	COG4166	transmembrane transport
KM400_RS01085	COG0656	L-ascorbic acid biosynthetic process
KM400_RS01105	COG4149	molybdate abc transporter
KM400_RS01110	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM400_RS01115	COG1910	domain protein
KM400_RS01125	COG0583	DNA-binding transcription factor activity
KM400_RS01130	COG0697	spore germination
KM400_RS01145	COG0204	Acyl-transferase
KM400_RS01155	COG1609	Transcriptional regulator
KM400_RS01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM400_RS01175	COG0084	hydrolase, TatD family'
KM400_RS01180	COG5298	Protein conserved in bacteria
KM400_RS01205	COG0488	(ABC) transporter
KM400_RS01220	COG0747	negative chemotaxis
KM400_RS01225	COG0601	transmembrane transport
KM400_RS01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM400_RS01235	COG0444	Belongs to the ABC transporter superfamily
KM400_RS01240	COG4608	Belongs to the ABC transporter superfamily
KM400_RS01270	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KM400_RS01275	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM400_RS01285	COG2814	Major facilitator Superfamily
KM400_RS01295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KM400_RS01305	COG4294	response to UV
KM400_RS01310	COG0457	Tetratricopeptide repeat
KM400_RS01310	COG0705	Rhomboid family
KM400_RS01320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KM400_RS01325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM400_RS01330	COG0864	Transcriptional regulator
KM400_RS01335	COG2337	Toxic component of a toxin-antitoxin (TA) module
KM400_RS01340	COG2183	response to ionizing radiation
KM400_RS01435	COG0802	atpase or kinase
KM400_RS01440	COG1214	PFAM Peptidase M22, glycoprotease
KM400_RS01445	COG0456	acetyltransferase
KM400_RS01455	COG0488	(ABC) transporter
KM400_RS01470	COG1266	CAAX protease self-immunity
KM400_RS01490	COG2252	PERMEase
KM400_RS01500	COG5002	protein histidine kinase activity
KM400_RS01525	COG1968	undecaprenyl-diphosphatase activity
KM400_RS01540	COG2205	protein histidine kinase activity
KM400_RS01545	COG0745	RESPONSE REGULATOR receiver
KM400_RS01570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KM400_RS01575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KM400_RS01580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KM400_RS01590	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KM400_RS01605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KM400_RS01615	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KM400_RS01625	COG0151	Belongs to the GarS family
KM400_RS01650	COG0210	DNA helicase
KM400_RS01660	COG4851	CamS sex pheromone cAM373 precursor
KM400_RS01680	COG1335	isochorismatase
KM400_RS01685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM400_RS01690	COG2011	ABC-type metal ion transport system permease component
KM400_RS01695	COG1464	Belongs to the NlpA lipoprotein family
KM400_RS01720	COG1846	Transcriptional regulator
KM400_RS01745	COG1597	lipid kinase activity
KM400_RS01750	COG0546	phosphoglycolate phosphatase activity
KM400_RS01755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM400_RS01765	COG1012	belongs to the aldehyde dehydrogenase family
KM400_RS01770	COG2076	Multidrug Resistance protein
KM400_RS01775	COG2309	aminopeptidase activity
KM400_RS01790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM400_RS01795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM400_RS01800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM400_RS01810	COG4807	Protein conserved in bacteria
KM400_RS01835	COG1757	Na H antiporter
KM400_RS01840	COG1473	amidohydrolase
KM400_RS01855	COG0450	alkyl hydroperoxide reductase
KM400_RS01875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM400_RS01880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM400_RS01885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM400_RS01900	COG0166	Belongs to the GPI family
KM400_RS01935	COG5002	protein histidine kinase activity
KM400_RS01955	COG3541	Predicted nucleotidyltransferase
KM400_RS01960	COG2814	Major facilitator Superfamily
KM400_RS01965	COG0723	plastoquinol--plastocyanin reductase activity
KM400_RS01965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM400_RS01975	COG0765	amino acid transport
KM400_RS01980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM400_RS01990	COG0840	transmembrane signaling receptor activity
KM400_RS01995	COG0840	transmembrane signaling receptor activity
KM400_RS02000	COG0366	Alpha amylase catalytic
KM400_RS02005	COG2190	(PTS) system
KM400_RS02005	COG1263	PTS System
KM400_RS02005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM400_RS02035	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KM400_RS02050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM400_RS02060	COG1116	anion transmembrane transporter activity
KM400_RS02065	COG0488	(ABC) transporter
KM400_RS02110	COG2270	Major facilitator Superfamily
KM400_RS02125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM400_RS02140	COG2310	stress, protein
KM400_RS02145	COG2310	stress, protein
KM400_RS02150	COG2310	stress, protein
KM400_RS02155	COG0861	Integral membrane protein TerC family
KM400_RS02165	COG3853	Toxic anion resistance protein (TelA)
KM400_RS02180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KM400_RS02190	COG1295	ribonuclease BN
KM400_RS02195	COG2217	Heavy metal translocating P-type atpase
KM400_RS02200	COG0697	spore germination
KM400_RS02220	COG0586	Pfam SNARE associated Golgi protein
KM400_RS02235	COG3871	stress protein (general stress protein 26)
KM400_RS02240	COG0387	Pfam Sodium calcium exchanger
KM400_RS02250	COG0535	radical SAM domain protein
KM400_RS02275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM400_RS02280	COG0582	viral genome integration into host DNA
KM400_RS02290	COG1396	sequence-specific DNA binding
KM400_RS02305	COG1396	sequence-specific DNA binding
KM400_RS02340	COG1484	DNA-dependent DNA replication
KM400_RS02570	COG0101	tRNA pseudouridine synthase activity
KM400_RS02580	COG3829	transcription factor binding
KM400_RS02590	COG0833	amino acid
KM400_RS02595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM400_RS02625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM400_RS02625	COG1263	PTS System
KM400_RS02630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM400_RS02645	COG0463	Glycosyl transferase, family 2
KM400_RS02655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KM400_RS02655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM400_RS02670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KM400_RS02690	COG1228	amidohydrolase
KM400_RS02695	COG1090	epimerase
KM400_RS02725	COG1988	membrane-bound metal-dependent
KM400_RS02730	COG1194	a g-specific adenine glycosylase
KM400_RS02755	COG1132	(ABC) transporter
KM400_RS02760	COG4129	membrane
KM400_RS02765	COG0067	glutamate synthase
KM400_RS02765	COG0069	glutamate synthase activity
KM400_RS02765	COG0070	glutamate synthase
KM400_RS02775	COG4555	ABC transporter
KM400_RS02795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KM400_RS02800	COG0735	belongs to the Fur family
KM400_RS02915	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KM400_RS02920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM400_RS02930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM400_RS02940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KM400_RS02950	COG2766	serine protein kinase
KM400_RS02970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM400_RS02980	COG1585	Membrane protein implicated in regulation of membrane protease activity
KM400_RS02985	COG2268	Band 7 protein
KM400_RS02995	COG3290	protein histidine kinase activity
KM400_RS03000	COG4565	transcriptional regulatory protein
KM400_RS03005	COG2851	Citrate transporter
KM400_RS03025	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM400_RS03030	COG3842	ATPase activity
KM400_RS03035	COG1175	transmembrane transport
KM400_RS03040	COG0395	ABC-type sugar transport system, permease component
KM400_RS03050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KM400_RS03055	COG0745	RESPONSE REGULATOR receiver
KM400_RS03060	COG5002	protein histidine kinase activity
KM400_RS03070	COG4990	cell redox homeostasis
KM400_RS03080	COG3290	protein histidine kinase activity
KM400_RS03085	COG4565	transcriptional regulatory protein
KM400_RS03090	COG3493	citrate carrier protein
KM400_RS03095	COG0281	malic enzyme
KM400_RS03110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM400_RS03120	COG5002	protein histidine kinase activity
KM400_RS03125	COG0745	RESPONSE REGULATOR receiver
KM400_RS03130	COG0456	acetyltransferase
KM400_RS03130	COG0454	-acetyltransferase
KM400_RS03135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM400_RS03140	COG3383	formate dehydrogenase (NAD+) activity
KM400_RS03160	COG0531	amino acid
KM400_RS03165	COG0640	Transcriptional regulator
KM400_RS03170	COG2217	Heavy metal translocating P-type atpase
KM400_RS03175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KM400_RS03190	COG3227	Zinc metalloprotease (Elastase)
KM400_RS03210	COG2720	vancomycin resistance protein
KM400_RS03215	COG1316	TRANSCRIPTIONal
KM400_RS03220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM400_RS03225	COG0346	lactoylglutathione lyase activity
KM400_RS03235	COG1027	Aspartate ammonia-lyase
KM400_RS03240	COG1620	l-lactate permease
KM400_RS03255	COG3104	oligopeptide transport
KM400_RS03260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM400_RS03265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM400_RS03270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM400_RS03280	COG2226	methyltransferase
KM400_RS03285	COG0156	8-amino-7-oxononanoate synthase activity
KM400_RS03290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM400_RS03300	COG4548	von Willebrand factor, type A
KM400_RS03305	COG0714	Associated with various cellular activities
KM400_RS03310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM400_RS03330	COG0531	amino acid
KM400_RS03335	COG2188	Transcriptional regulator
KM400_RS03340	COG1263	PTS System
KM400_RS03340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM400_RS03345	COG0366	Alpha amylase catalytic
KM400_RS03360	COG0697	spore germination
KM400_RS03370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM400_RS03375	COG1115	amino acid carrier protein
KM400_RS03380	COG1126	abc transporter atp-binding protein
KM400_RS03385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM400_RS03390	COG0765	amino acid transport
KM400_RS03395	COG0765	amino acid transport
KM400_RS03400	COG0833	amino acid
KM400_RS03425	COG2378	regulation of single-species biofilm formation
KM400_RS03430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KM400_RS03435	COG5002	protein histidine kinase activity
KM400_RS03450	COG0659	secondary active sulfate transmembrane transporter activity
KM400_RS03465	COG0747	negative chemotaxis
KM400_RS03475	COG0601	transmembrane transport
KM400_RS03480	COG4608	Belongs to the ABC transporter superfamily
KM400_RS03490	COG2271	Major facilitator Superfamily
KM400_RS03495	COG1846	Transcriptional regulator
KM400_RS03505	COG1609	Transcriptional regulator
KM400_RS03510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM400_RS03525	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM400_RS03530	COG1879	ABC-type sugar transport system periplasmic component
KM400_RS03555	COG1063	alcohol dehydrogenase
KM400_RS03570	COG3568	Endonuclease Exonuclease Phosphatase
KM400_RS03595	COG1968	undecaprenyl-diphosphatase activity
KM400_RS03600	COG0840	transmembrane signaling receptor activity
KM400_RS03605	COG3584	3D domain protein
KM400_RS03605	COG1388	LysM domain
KM400_RS03610	COG1476	TRANSCRIPTIONal
KM400_RS03625	COG3104	oligopeptide transport
KM400_RS03630	COG1114	Component of the transport system for branched-chain amino acids
KM400_RS03645	COG1113	amino acid transport
KM400_RS03650	COG2252	PERMEase
KM400_RS03675	COG0475	glutathione-regulated potassium exporter activity
KM400_RS03675	COG0569	domain protein
KM400_RS03690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM400_RS03695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KM400_RS03700	COG4990	cell redox homeostasis
KM400_RS03715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM400_RS03720	COG0697	spore germination
KM400_RS03725	COG0531	amino acid
KM400_RS03735	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM400_RS03740	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM400_RS03745	COG1918	ferrous iron import across plasma membrane
KM400_RS03745	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM400_RS03750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM400_RS03755	COG0573	inorganic phosphate transmembrane transporter activity
KM400_RS03760	COG0581	inorganic phosphate transmembrane transporter activity
KM400_RS03770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM400_RS03890	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KM400_RS03910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM400_RS03915	COG1116	anion transmembrane transporter activity
KM400_RS03920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM400_RS03925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM400_RS03930	COG0352	thiamine-phosphate diphosphorylase activity
KM400_RS03935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM400_RS03940	COG2104	thiamine diphosphate biosynthetic process
KM400_RS03950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM400_RS03955	COG0351	phosphomethylpyrimidine kinase
KM400_RS03995	COG2205	protein histidine kinase activity
KM400_RS04000	COG2814	Major facilitator Superfamily
KM400_RS04005	COG1846	Transcriptional regulator
KM400_RS04020	COG2252	PERMEase
KM400_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS04030	COG1376	ErfK ybiS ycfS ynhG family protein
KM400_RS04040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM400_RS04045	COG1621	beta-fructofuranosidase activity
KM400_RS04050	COG1263	PTS System
KM400_RS04050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM400_RS04055	COG1609	Transcriptional regulator
KM400_RS04065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM400_RS04105	COG0778	Nitroreductase
KM400_RS04110	COG2719	SpoVR family
KM400_RS04135	COG0446	pyridine nucleotide-disulphide oxidoreductase
KM400_RS04140	COG1937	Protein conserved in bacteria
KM400_RS04145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM400_RS04145	COG0425	Belongs to the sulfur carrier protein TusA family
KM400_RS04150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM400_RS04150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM400_RS04155	COG0425	Belongs to the sulfur carrier protein TusA family
KM400_RS04170	COG2210	Belongs to the sulfur carrier protein TusA family
KM400_RS04175	COG0730	response to heat
KM400_RS04185	COG1316	TRANSCRIPTIONal
KM400_RS04190	COG0604	alcohol dehydrogenase
KM400_RS04195	COG1283	sodium-dependent phosphate transmembrane transporter activity
KM400_RS04210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM400_RS04210	COG3711	transcriptional antiterminator
KM400_RS04215	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM400_RS04220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM400_RS04240	COG3584	3D domain protein
KM400_RS04240	COG1388	LysM domain
KM400_RS04245	COG0577	efflux transmembrane transporter activity
KM400_RS04250	COG1136	(ABC) transporter
KM400_RS04260	COG5522	Integral membrane protein (intg_mem_TP0381)
KM400_RS04275	COG1114	Component of the transport system for branched-chain amino acids
KM400_RS04280	COG3546	catalase activity
KM400_RS04315	COG0586	Pfam SNARE associated Golgi protein
KM400_RS04355	COG0531	amino acid
KM400_RS04360	COG0475	glutathione-regulated potassium exporter activity
KM400_RS04370	COG1737	Transcriptional regulator
KM400_RS04380	COG1263	PTS System
KM400_RS04380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM400_RS04390	COG2259	Doxx family
KM400_RS04405	COG0697	spore germination
KM400_RS04410	COG1522	sequence-specific DNA binding
KM400_RS04425	COG2076	Multidrug Resistance protein
KM400_RS04430	COG1309	transcriptional regulator
KM400_RS04435	COG2814	Major facilitator Superfamily
KM400_RS04440	COG1733	regulation of RNA biosynthetic process
KM400_RS04450	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM400_RS04455	COG4533	DNA binding
KM400_RS04460	COG2211	Major facilitator Superfamily
KM400_RS04470	COG0693	protein deglycase activity
KM400_RS04475	COG0693	protein deglycase activity
KM400_RS04475	COG0753	catalase activity
KM400_RS04485	COG0531	amino acid
KM400_RS04490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KM400_RS04500	COG1012	belongs to the aldehyde dehydrogenase family
KM400_RS04505	COG1132	(ABC) transporter
KM400_RS04515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM400_RS04520	COG0765	amino acid transport
KM400_RS04525	COG1126	abc transporter atp-binding protein
KM400_RS04540	COG0189	ligase activity
KM400_RS04570	COG0028	Belongs to the TPP enzyme family
KM400_RS04575	COG3527	Alpha-acetolactate decarboxylase
KM400_RS04590	COG0561	phosphatase activity
KM400_RS04605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM400_RS04620	COG0659	secondary active sulfate transmembrane transporter activity
KM400_RS04640	COG0653	protein targeting
KM400_RS04645	COG2244	polysaccharide biosynthetic process
KM400_RS04655	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM400_RS04660	COG4196	transglutaminase domain protein
KM400_RS04675	COG1696	Membrane protein involved in D-alanine export
KM400_RS04690	COG1024	Enoyl-CoA hydratase
KM400_RS04705	COG1363	Peptidase, m42
KM400_RS04725	COG3938	Belongs to the proline racemase family
KM400_RS04765	COG0601	transmembrane transport
KM400_RS04770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM400_RS04780	COG4608	Belongs to the ABC transporter superfamily
KM400_RS04815	COG0477	Major facilitator Superfamily
KM400_RS04820	COG3290	protein histidine kinase activity
KM400_RS04825	COG4565	transcriptional regulatory protein
KM400_RS04830	COG3181	Tripartite tricarboxylate transporter family receptor
KM400_RS04860	COG0789	Transcriptional regulator
KM400_RS04860	COG4978	Transcriptional regulator
KM400_RS04875	COG0305	Participates in initiation and elongation during chromosome replication
KM400_RS04915	COG0477	Major facilitator Superfamily
KM400_RS04965	COG1309	transcriptional regulator
KM400_RS04985	COG1183	phosphatidylcholine synthase activity
KM400_RS05005	COG2376	Dihydroxyacetone kinase
KM400_RS05015	COG2376	Dihydroxyacetone kinase
KM400_RS05020	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM400_RS05025	COG1959	2 iron, 2 sulfur cluster binding
KM400_RS05055	COG2770	Histidine kinase
KM400_RS05055	COG3437	response regulator, receiver
KM400_RS05110	COG3237	CsbD-like
KM400_RS05135	COG1191	sigma factor activity
KM400_RS05145	COG2208	phosphoserine phosphatase activity
KM400_RS05150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM400_RS05155	COG0784	Response regulator, receiver
KM400_RS05155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM400_RS05155	COG2198	Histidine kinase
KM400_RS05155	COG2205	protein histidine kinase activity
KM400_RS05210	COG0420	3'-5' exonuclease activity
KM400_RS05235	COG1309	transcriptional regulator
KM400_RS05240	COG2814	Major facilitator Superfamily
KM400_RS05245	COG0346	lactoylglutathione lyase activity
KM400_RS05250	COG0346	lactoylglutathione lyase activity
KM400_RS05255	COG0457	Tetratricopeptide repeat
KM400_RS05260	COG2267	carboxylic ester hydrolase activity
KM400_RS05280	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM400_RS05285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KM400_RS05295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KM400_RS05335	COG0477	Major facilitator Superfamily
KM400_RS05340	COG0477	Major facilitator Superfamily
KM400_RS05350	COG3973	AAA domain
KM400_RS05355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM400_RS05375	COG4980	gas vesicle protein
KM400_RS05380	COG0537	adenosine 5'-monophosphoramidase activity
KM400_RS05385	COG1131	(ABC) transporter
KM400_RS05390	COG4473	ABC transporter
KM400_RS05405	COG1309	transcriptional regulator
KM400_RS05415	COG3402	PFAM membrane-flanked domain
KM400_RS05460	COG3402	PFAM membrane-flanked domain
KM400_RS05465	COG3428	Bacterial PH domain
KM400_RS05470	COG2329	Antibiotic biosynthesis monooxygenase
KM400_RS05475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM400_RS05480	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KM400_RS05485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM400_RS05490	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM400_RS05525	COG1309	transcriptional regulator
KM400_RS05530	COG1511	domain protein
KM400_RS05555	COG1609	Transcriptional regulator
KM400_RS05565	COG1234	tRNA 3'-trailer cleavage
KM400_RS05570	COG0095	Lipoate-protein ligase
KM400_RS05580	COG0318	PFAM AMP-dependent synthetase and ligase
KM400_RS05610	COG3209	COG3209 Rhs family protein
KM400_RS05650	COG1078	dGTPase activity
KM400_RS05660	COG1595	DNA-templated transcription, initiation
KM400_RS05665	COG2207	Transcriptional regulator
KM400_RS05665	COG3708	Transcriptional regulator
KM400_RS05680	COG2205	protein histidine kinase activity
KM400_RS05685	COG0745	RESPONSE REGULATOR receiver
KM400_RS05710	COG0501	Belongs to the peptidase M48B family
KM400_RS05715	COG0840	transmembrane signaling receptor activity
KM400_RS05720	COG0697	spore germination
KM400_RS05740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KM400_RS05745	COG2224	Isocitrate lyase
KM400_RS05770	COG4903	ComK protein
KM400_RS05775	COG0398	Pfam SNARE associated Golgi protein
KM400_RS05785	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KM400_RS05790	COG1074	ATP-dependent DNA helicase activity
KM400_RS05835	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM400_RS05860	COG0367	asparagine synthase
KM400_RS05865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM400_RS05870	COG0753	catalase activity
KM400_RS05875	COG0004	ammonium transporteR
KM400_RS05895	COG2996	Protein conserved in bacteria
KM400_RS05905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM400_RS05915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM400_RS05930	COG0561	phosphatase activity
KM400_RS05940	COG0542	response to heat
KM400_RS05950	COG2267	carboxylic ester hydrolase activity
KM400_RS05965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM400_RS05970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KM400_RS05975	COG5504	Zn-dependent protease
KM400_RS05985	COG0180	Tryptophanyl-tRNA synthetase
KM400_RS05995	COG4166	transmembrane transport
KM400_RS06000	COG0601	transmembrane transport
KM400_RS06005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM400_RS06010	COG0444	Belongs to the ABC transporter superfamily
KM400_RS06015	COG4608	Belongs to the ABC transporter superfamily
KM400_RS06020	COG0534	Mate efflux family protein
KM400_RS06025	COG4166	transmembrane transport
KM400_RS06040	COG0861	Integral membrane protein TerC family
KM400_RS06045	COG4862	establishment of competence for transformation
KM400_RS06050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM400_RS06060	COG1164	Oligoendopeptidase f
KM400_RS06070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM400_RS06075	COG2346	COG2346, Truncated hemoglobins
KM400_RS06080	COG4116	CYTH
KM400_RS06090	COG2357	RelA SpoT domain protein
KM400_RS06100	COG0564	pseudouridine synthase activity
KM400_RS06120	COG0463	Glycosyl transferase, family 2
KM400_RS06120	COG1216	Glycosyl transferase, family 2
KM400_RS06160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KM400_RS06175	COG1091	dTDP-4-dehydrorhamnose reductase activity
KM400_RS06220	COG2153	protein acetylation
KM400_RS06230	COG2382	esterase
KM400_RS06245	COG5492	domain, Protein
KM400_RS06250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM400_RS06260	COG0512	Glutamine amidotransferase of anthranilate synthase
KM400_RS06260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KM400_RS06295	COG1620	l-lactate permease
KM400_RS06300	COG5634	Uncharacterized conserved protein (DUF2278)
KM400_RS06355	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM400_RS06365	COG1476	TRANSCRIPTIONal
KM400_RS06425	COG2226	methyltransferase
KM400_RS06435	COG1686	Belongs to the peptidase S11 family
KM400_RS06440	COG0681	Belongs to the peptidase S26 family
KM400_RS06475	COG1012	belongs to the aldehyde dehydrogenase family
KM400_RS06480	COG3842	ATPase activity
KM400_RS06485	COG1176	ABC-type spermidine putrescine transport system, permease component I
KM400_RS06490	COG1177	transmembrane transport
KM400_RS06495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM400_RS06505	COG2409	Drug exporters of the RND superfamily
KM400_RS06515	COG0564	pseudouridine synthase activity
KM400_RS06525	COG2340	Cysteine-rich secretory protein family
KM400_RS06530	COG0247	lactate metabolic process
KM400_RS06535	COG0277	FAD linked oxidase domain protein
KM400_RS06540	COG3835	regulator
KM400_RS06550	COG0745	RESPONSE REGULATOR receiver
KM400_RS06555	COG5002	protein histidine kinase activity
KM400_RS06560	COG2186	Transcriptional regulator
KM400_RS06580	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KM400_RS06590	COG2116	formate transmembrane transporter activity
KM400_RS06595	COG0861	Integral membrane protein TerC family
KM400_RS06610	COG2030	dehydratase
KM400_RS06630	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS06635	COG3243	poly(R)-hydroxyalkanoic acid synthase
KM400_RS06640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM400_RS06645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM400_RS06660	COG1840	ABC-type Fe3 transport system, periplasmic component
KM400_RS06690	COG1349	DNA-binding transcription factor activity
KM400_RS06710	COG2861	carbohydrate metabolic process
KM400_RS06720	COG3852	Histidine kinase
KM400_RS06725	COG1846	Transcriptional regulator
KM400_RS06735	COG2318	DinB family
KM400_RS06745	COG5002	protein histidine kinase activity
KM400_RS06755	COG0720	synthase
KM400_RS06770	COG4873	Protein conserved in bacteria
KM400_RS06800	COG1780	Probably involved in ribonucleotide reductase function
KM400_RS06820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM400_RS06825	COG1725	Transcriptional regulator
KM400_RS06830	COG1131	(ABC) transporter
KM400_RS06840	COG1131	(ABC) transporter
KM400_RS06845	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM400_RS06860	COG1522	sequence-specific DNA binding
KM400_RS06870	COG1335	isochorismatase
KM400_RS06880	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM400_RS06885	COG2070	2-Nitropropane dioxygenase
KM400_RS06890	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM400_RS06900	COG1696	Membrane protein involved in D-alanine export
KM400_RS06925	COG0716	FMN binding
KM400_RS06940	COG3173	Aminoglycoside phosphotransferase
KM400_RS06960	COG0534	Mate efflux family protein
KM400_RS06965	COG1968	undecaprenyl-diphosphatase activity
KM400_RS06980	COG1846	Transcriptional regulator
KM400_RS06990	COG1301	dicarboxylic acid transport
KM400_RS07000	COG4709	membrane
KM400_RS07005	COG3874	Sporulation protein YtfJ
KM400_RS07030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM400_RS07035	COG0028	Belongs to the TPP enzyme family
KM400_RS07040	COG0440	acetolactate synthase activity
KM400_RS07045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM400_RS07055	COG0473	3-isopropylmalate dehydrogenase activity
KM400_RS07080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KM400_RS07115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM400_RS07130	COG1183	phosphatidylcholine synthase activity
KM400_RS07135	COG1368	sulfuric ester hydrolase activity
KM400_RS07145	COG0019	diaminopimelate decarboxylase activity
KM400_RS07165	COG0529	Catalyzes the synthesis of activated sulfate
KM400_RS07170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM400_RS07195	COG0733	neurotransmitter:sodium symporter activity
KM400_RS07215	COG1757	Na H antiporter
KM400_RS07230	COG4758	membrane
KM400_RS07235	COG4585	Histidine kinase
KM400_RS07240	COG2197	response regulator
KM400_RS07250	COG1114	Component of the transport system for branched-chain amino acids
KM400_RS07260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KM400_RS07285	COG1017	nitric oxide dioxygenase activity
KM400_RS07285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KM400_RS07300	COG0730	response to heat
KM400_RS07305	COG0306	phosphate transporter
KM400_RS07310	COG1392	Phosphate transport regulator
KM400_RS07335	COG1801	Protein of unknown function DUF72
KM400_RS07345	COG0582	viral genome integration into host DNA
KM400_RS07350	COG5002	protein histidine kinase activity
KM400_RS07370	COG0392	lysyltransferase activity
KM400_RS07370	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KM400_RS07385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM400_RS07390	COG1686	Belongs to the peptidase S11 family
KM400_RS07395	COG2715	membrane protein required for spore maturation
KM400_RS07400	COG0700	Nucleoside recognition
KM400_RS07405	COG1187	pseudouridine synthase activity
KM400_RS07415	COG1333	cytochrome c biogenesis protein
KM400_RS07420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM400_RS07425	COG0745	RESPONSE REGULATOR receiver
KM400_RS07430	COG5002	protein histidine kinase activity
KM400_RS07435	COG2096	Adenosyltransferase
KM400_RS07450	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KM400_RS07455	COG1141	Ferredoxin
KM400_RS07460	COG4955	Helix-turn-helix domain
KM400_RS07465	COG0514	ATP-dependent DNA helicase (RecQ)
KM400_RS07470	COG1266	CAAX protease self-immunity
KM400_RS07490	COG4862	establishment of competence for transformation
KM400_RS07495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KM400_RS07515	COG0492	ferredoxin-NADP+ reductase activity
KM400_RS07520	COG0252	asparaginase activity
KM400_RS07590	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM400_RS07605	COG0142	geranyltranstransferase activity
KM400_RS07615	COG0142	geranyltranstransferase activity
KM400_RS07635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM400_RS07640	COG0457	Tetratricopeptide repeat
KM400_RS07660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KM400_RS07670	COG4347	Protein of unknown function (DUF1405)
KM400_RS07685	COG2738	Putative neutral zinc metallopeptidase
KM400_RS07695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM400_RS07700	COG1694	Mazg nucleotide pyrophosphohydrolase
KM400_RS07715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM400_RS07720	COG0438	transferase activity, transferring glycosyl groups
KM400_RS07775	COG3935	DnaD domain protein
KM400_RS07780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KM400_RS07790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM400_RS07790	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM400_RS07850	COG0116	Belongs to the methyltransferase superfamily
KM400_RS07860	COG1199	ATP-dependent helicase activity
KM400_RS07865	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KM400_RS07875	COG3173	Aminoglycoside phosphotransferase
KM400_RS07880	COG0024	Methionine aminopeptidase
KM400_RS07890	COG2233	PERMEase
KM400_RS07895	COG2311	Membrane
KM400_RS07900	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM400_RS07910	COG0456	acetyltransferase
KM400_RS07960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM400_RS07985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KM400_RS08000	COG1215	transferase activity, transferring glycosyl groups
KM400_RS08020	COG0454	-acetyltransferase
KM400_RS08040	COG0328	RNA-DNA hybrid ribonuclease activity
KM400_RS08080	COG1280	lysine exporter protein (LysE YggA)
KM400_RS08095	COG3162	membrane
KM400_RS08100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM400_RS08105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM400_RS08115	COG0475	glutathione-regulated potassium exporter activity
KM400_RS08120	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM400_RS08125	COG0789	Transcriptional regulator
KM400_RS08125	COG4978	Transcriptional regulator
KM400_RS08135	COG2323	membrane
KM400_RS08140	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KM400_RS08195	COG1923	regulation of RNA biosynthetic process
KM400_RS08205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM400_RS08210	COG1360	Flagellar Motor Protein
KM400_RS08215	COG2201	protein-glutamate methylesterase activity
KM400_RS08225	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM400_RS08225	COG1776	CheC inhibitor of MCP methylation
KM400_RS08240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM400_RS08260	COG1256	bacterial-type flagellum assembly
KM400_RS08285	COG1815	bacterial-type flagellum-dependent cell motility
KM400_RS08290	COG1558	bacterial-type flagellum-dependent cell motility
KM400_RS08305	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM400_RS08315	COG1157	protein secretion by the type III secretion system
KM400_RS08350	COG0835	chemotaxis
KM400_RS08350	COG0784	Response regulator, receiver
KM400_RS08360	COG0463	Glycosyl transferase, family 2
KM400_RS08390	COG0463	Glycosyl transferase, family 2
KM400_RS08390	COG0457	Tetratricopeptide repeat
KM400_RS08405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM400_RS08410	COG0741	lytic transglycosylase activity
KM400_RS08425	COG1776	CheC inhibitor of MCP methylation
KM400_RS08425	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM400_RS08435	COG1338	Plays a role in the flagellum-specific transport system
KM400_RS08440	COG1987	bacterial-type flagellum assembly
KM400_RS08450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM400_RS08455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM400_RS08460	COG1419	protein localization to endoplasmic reticulum
KM400_RS08465	COG4786	Flagellar basal body rod
KM400_RS08470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM400_RS08495	COG1309	transcriptional regulator
KM400_RS08515	COG2329	Antibiotic biosynthesis monooxygenase
KM400_RS08545	COG3842	ATPase activity
KM400_RS08550	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM400_RS08560	COG1234	tRNA 3'-trailer cleavage
KM400_RS08585	COG1686	Belongs to the peptidase S11 family
KM400_RS08595	COG0406	alpha-ribazole phosphatase activity
KM400_RS08625	COG0367	asparagine synthase
KM400_RS08655	COG1802	Transcriptional regulator
KM400_RS08660	COG0697	spore germination
KM400_RS08665	COG0523	cobalamin synthesis protein
KM400_RS08670	COG0701	Predicted permease
KM400_RS08680	COG0438	transferase activity, transferring glycosyl groups
KM400_RS08680	COG1216	Glycosyl transferase, family 2
KM400_RS08685	COG1757	Na H antiporter
KM400_RS08690	COG0114	fumarate hydratase activity
KM400_RS08715	COG3340	Belongs to the peptidase S51 family
KM400_RS08735	COG0785	Cytochrome C biogenesis protein
KM400_RS08765	COG2733	membrane
KM400_RS08800	COG1131	(ABC) transporter
KM400_RS08815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM400_RS08820	COG0528	UMP kinase activity
KM400_RS08830	COG1027	Aspartate ammonia-lyase
KM400_RS08835	COG0281	malic enzyme
KM400_RS08840	COG4191	Histidine kinase
KM400_RS08845	COG0784	Response regulator, receiver
KM400_RS08850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM400_RS08910	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM400_RS08920	COG2814	Major facilitator Superfamily
KM400_RS08935	COG1966	Carbon starvation protein
KM400_RS08945	COG0477	Major facilitator Superfamily
KM400_RS08950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM400_RS08960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM400_RS08975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM400_RS08990	COG2244	polysaccharide biosynthetic process
KM400_RS08995	COG0733	neurotransmitter:sodium symporter activity
KM400_RS09005	COG5566	PFAM Mor transcription activator
KM400_RS09010	COG2323	membrane
KM400_RS09030	COG2084	Dehydrogenase
KM400_RS09045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM400_RS09055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM400_RS09060	COG0028	Belongs to the TPP enzyme family
KM400_RS09065	COG0440	acetolactate synthase activity
KM400_RS09070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM400_RS09080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KM400_RS09110	COG3384	dioxygenase
KM400_RS09120	COG3279	Response regulator of the LytR AlgR family
KM400_RS09125	COG0427	acetyl-CoA hydrolase
KM400_RS09145	COG1073	alpha beta
KM400_RS09150	COG4166	transmembrane transport
KM400_RS09175	COG0535	radical SAM domain protein
KM400_RS09180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM400_RS09200	COG1914	H( )-stimulated, divalent metal cation uptake system
KM400_RS09215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM400_RS09245	COG2390	Transcriptional regulator
KM400_RS09255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM400_RS09260	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KM400_RS09275	COG4224	UPF0291 protein
KM400_RS09295	COG0006	proline dipeptidase activity
KM400_RS09300	COG2132	Multicopper oxidase
KM400_RS09315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM400_RS09330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM400_RS09345	COG1276	copper resistance
KM400_RS09345	COG2372	response to copper ion
KM400_RS09350	COG4549	nuclear export factor GLE1
KM400_RS09360	COG0697	spore germination
KM400_RS09365	COG0583	DNA-binding transcription factor activity
KM400_RS09370	COG1959	2 iron, 2 sulfur cluster binding
KM400_RS09375	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM400_RS09380	COG0778	Nitroreductase
KM400_RS09390	COG0628	permease
KM400_RS09400	COG1231	oxidoreductase activity
KM400_RS09405	COG0523	cobalamin synthesis protein
KM400_RS09420	COG0318	PFAM AMP-dependent synthetase and ligase
KM400_RS09425	COG2030	dehydratase
KM400_RS09430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM400_RS09440	COG0411	ABC transporter
KM400_RS09460	COG0583	DNA-binding transcription factor activity
KM400_RS09470	COG1942	4-Oxalocrotonate Tautomerase
KM400_RS09480	COG1846	Transcriptional regulator
KM400_RS09490	COG1271	oxidase subunit
KM400_RS09495	COG1294	oxidase, subunit
KM400_RS09500	COG4988	ABC transporter
KM400_RS09505	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KM400_RS09525	COG1686	Belongs to the peptidase S11 family
KM400_RS09540	COG1388	LysM domain
KM400_RS09540	COG0791	NLP P60 protein
KM400_RS09555	COG0745	RESPONSE REGULATOR receiver
KM400_RS09570	COG0300	oxidoreductase activity
KM400_RS09605	COG0460	homoserine dehydrogenase
KM400_RS09630	COG1316	TRANSCRIPTIONal
KM400_RS09640	COG0745	RESPONSE REGULATOR receiver
KM400_RS09645	COG5002	protein histidine kinase activity
KM400_RS09660	COG1285	pathogenesis
KM400_RS09665	COG1247	-acetyltransferase
KM400_RS09685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM400_RS09695	COG1082	Xylose isomerase domain protein TIM barrel
KM400_RS09705	COG2814	Major facilitator Superfamily
KM400_RS09710	COG1279	arginine transmembrane transporter activity
KM400_RS09720	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM400_RS09755	COG0577	efflux transmembrane transporter activity
KM400_RS09760	COG2002	toxin-antitoxin pair type II binding
KM400_RS09765	COG1404	Belongs to the peptidase S8 family
KM400_RS09770	COG0640	Transcriptional regulator
KM400_RS09775	COG0667	Aldo Keto reductase
KM400_RS09805	COG0840	transmembrane signaling receptor activity
KM400_RS09820	COG3949	Membrane
KM400_RS09825	COG0783	Belongs to the Dps family
KM400_RS09840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM400_RS09850	COG1231	oxidoreductase activity
KM400_RS09860	COG4989	oxidoreductase activity
KM400_RS09865	COG0523	cobalamin synthesis protein
KM400_RS09870	COG0456	acetyltransferase
KM400_RS09930	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM400_RS09930	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM400_RS09940	COG0702	epimerase
KM400_RS09950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM400_RS09960	COG4166	transmembrane transport
KM400_RS09975	COG0406	alpha-ribazole phosphatase activity
KM400_RS09985	COG5337	Spore coat protein CotH
KM400_RS09990	COG1051	belongs to the nudix hydrolase family
KM400_RS09995	COG0586	Pfam SNARE associated Golgi protein
KM400_RS10000	COG2244	polysaccharide biosynthetic process
KM400_RS10010	COG0701	Predicted permease
KM400_RS10015	COG3689	TIGRFAM TIGR03943 family protein
KM400_RS10020	COG1607	acyl-coa hydrolase
KM400_RS10030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM400_RS10045	COG0702	epimerase
KM400_RS10050	COG2839	Protein conserved in bacteria
KM400_RS10055	COG1253	flavin adenine dinucleotide binding
KM400_RS10070	COG1114	Component of the transport system for branched-chain amino acids
KM400_RS10075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM400_RS10095	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM400_RS10105	COG1876	peptidase activity
KM400_RS10115	COG0154	amidase activity
KM400_RS10120	COG2211	Major facilitator Superfamily
KM400_RS10140	COG0561	phosphatase activity
KM400_RS10150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM400_RS10155	COG4106	trans-aconitate 2-methyltransferase activity
KM400_RS10170	COG1819	glycosyl
KM400_RS10175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM400_RS10180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM400_RS10215	COG0456	acetyltransferase
KM400_RS10270	COG3874	Sporulation protein YtfJ
KM400_RS10295	COG2226	methyltransferase
KM400_RS10320	COG0346	lactoylglutathione lyase activity
KM400_RS10330	COG0604	alcohol dehydrogenase
KM400_RS10335	COG1595	DNA-templated transcription, initiation
KM400_RS10360	COG0386	Belongs to the glutathione peroxidase family
KM400_RS10365	COG1305	Transglutaminase-like
KM400_RS10370	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KM400_RS10375	COG0714	Associated with various cellular activities
KM400_RS10390	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KM400_RS10395	COG1140	nitrate reductase beta subunit
KM400_RS10400	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KM400_RS10405	COG2181	nitrate reductase activity
KM400_RS10425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM400_RS10430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM400_RS10435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM400_RS10440	COG0303	'Molybdopterin
KM400_RS10445	COG0314	molybdopterin synthase activity
KM400_RS10455	COG2223	nitrite transmembrane transporter activity
KM400_RS10470	COG1648	precorrin-2 dehydrogenase activity
KM400_RS10480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM400_RS10480	COG1587	Uroporphyrinogen-III synthase
KM400_RS10485	COG2146	nitrite reductase [NAD(P)H] activity
KM400_RS10490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM400_RS10495	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KM400_RS10530	COG2359	stage V sporulation protein S
KM400_RS10555	COG1418	mRNA catabolic process
KM400_RS10560	COG0488	(ABC) transporter
KM400_RS10575	COG0629	single-stranded DNA binding
KM400_RS10590	COG1413	lyase activity
KM400_RS10605	COG2136	Putative SAM-dependent methyltransferase
KM400_RS10605	COG2521	methyltransferase
KM400_RS10610	COG0018	arginyl-trna synthetase
KM400_RS10635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KM400_RS10655	COG0017	Asparaginyl-tRNA synthetase
KM400_RS10675	COG1674	ftsk spoiiie
KM400_RS10745	COG1929	Belongs to the glycerate kinase type-1 family
KM400_RS10750	COG0471	metal ion transport
KM400_RS10755	COG0745	RESPONSE REGULATOR receiver
KM400_RS10760	COG3850	Histidine kinase
KM400_RS10760	COG5002	protein histidine kinase activity
KM400_RS10775	COG0733	neurotransmitter:sodium symporter activity
KM400_RS10800	COG2610	gluconate transmembrane transporter activity
KM400_RS10805	COG1454	alcohol dehydrogenase
KM400_RS10810	COG1794	racemase activity, acting on amino acids and derivatives
KM400_RS10820	COG0456	acetyltransferase
KM400_RS10835	COG1131	(ABC) transporter
KM400_RS10850	COG0546	phosphoglycolate phosphatase activity
KM400_RS10870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM400_RS10885	COG0768	penicillin binding
KM400_RS10890	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM400_RS10895	COG0204	Acyl-transferase
KM400_RS10900	COG1272	protein, Hemolysin III
KM400_RS10910	COG0805	protein transport
KM400_RS10920	COG1307	EDD domain protein, DegV family
KM400_RS10925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KM400_RS10930	COG1999	signal sequence binding
KM400_RS10935	COG0071	Belongs to the small heat shock protein (HSP20) family
KM400_RS10940	COG0367	asparagine synthase
KM400_RS10955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM400_RS10960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM400_RS10995	COG0668	transmembrane transport
KM400_RS11000	COG2203	Gaf domain
KM400_RS11000	COG4585	Histidine kinase
KM400_RS11005	COG2197	response regulator
KM400_RS11015	COG1064	alcohol dehydrogenase
KM400_RS11070	COG0517	IMP dehydrogenase activity
KM400_RS11070	COG1125	glycine betaine transport
KM400_RS11075	COG1174	glycine betaine transport
KM400_RS11110	COG1253	flavin adenine dinucleotide binding
KM400_RS11115	COG1012	belongs to the aldehyde dehydrogenase family
KM400_RS11120	COG5506	Protein of unknown function (DUF1694)
KM400_RS11135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM400_RS11140	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KM400_RS11145	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KM400_RS11150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM400_RS11155	COG0456	acetyltransferase
KM400_RS11160	COG3829	transcription factor binding
KM400_RS11165	COG1509	lysine 2,3-aminomutase activity
KM400_RS11205	COG4326	sporulation control protein
KM400_RS11210	COG0671	phosphoesterase, PA-phosphatase related
KM400_RS11215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM400_RS11220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM400_RS11250	COG1715	Restriction endonuclease
KM400_RS11250	COG1787	Restriction endonuclease
KM400_RS11340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM400_RS11380	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM400_RS11380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM400_RS11390	COG2814	Major facilitator Superfamily
KM400_RS11395	COG4841	protein insertion into membrane
KM400_RS11400	COG0372	Belongs to the citrate synthase family
KM400_RS11405	COG2079	MmgE PrpD family protein
KM400_RS11410	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KM400_RS11415	COG1960	acyl-CoA dehydrogenase activity
KM400_RS11420	COG2084	Dehydrogenase
KM400_RS11430	COG1280	lysine exporter protein (LysE YggA)
KM400_RS11435	COG1024	Enoyl-CoA hydratase
KM400_RS11450	COG0420	3'-5' exonuclease activity
KM400_RS11455	COG0419	ATPase involved in DNA repair
KM400_RS11480	COG2223	nitrite transmembrane transporter activity
KM400_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS11490	COG1169	isochorismate synthase
KM400_RS11495	COG1021	2,3-dihydroxybenzoate-AMP ligase
KM400_RS11500	COG3433	isochorismatase activity
KM400_RS11500	COG1535	isochorismatase
KM400_RS11510	COG3251	PFAM MbtH domain protein
KM400_RS11515	COG2814	Major facilitator Superfamily
KM400_RS11530	COG0776	regulation of translation
KM400_RS11540	COG2318	DinB family
KM400_RS11565	COG2329	Antibiotic biosynthesis monooxygenase
KM400_RS11570	COG1187	pseudouridine synthase activity
KM400_RS11575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM400_RS11590	COG0596	Alpha beta hydrolase
KM400_RS11595	COG2814	Major facilitator Superfamily
KM400_RS11615	COG2226	methyltransferase
KM400_RS11660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM400_RS11695	COG1247	-acetyltransferase
KM400_RS11725	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM400_RS11735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM400_RS11745	COG1278	Cold shock
KM400_RS11760	COG0010	Belongs to the arginase family
KM400_RS11765	COG0561	phosphatase activity
KM400_RS11810	COG0583	DNA-binding transcription factor activity
KM400_RS11815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM400_RS11830	COG0583	DNA-binding transcription factor activity
KM400_RS11835	COG2258	MOSC domain
KM400_RS11850	COG1132	(ABC) transporter
KM400_RS11855	COG1132	(ABC) transporter
KM400_RS11875	COG1396	sequence-specific DNA binding
KM400_RS11900	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KM400_RS11905	COG1595	DNA-templated transcription, initiation
KM400_RS11930	COG1649	PFAM Uncharacterised BCR, COG1649
KM400_RS11955	COG2971	BadF BadG BcrA BcrD
KM400_RS11960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM400_RS11965	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM400_RS11985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM400_RS12015	COG1309	transcriptional regulator
KM400_RS12030	COG1136	(ABC) transporter
KM400_RS12030	COG0577	efflux transmembrane transporter activity
KM400_RS12035	COG0500	methyltransferase
KM400_RS12035	COG3615	Tellurite resistance protein tehB
KM400_RS12045	COG2226	methyltransferase
KM400_RS12050	COG3961	Belongs to the TPP enzyme family
KM400_RS12055	COG1846	Transcriptional regulator
KM400_RS12095	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM400_RS12110	COG1595	DNA-templated transcription, initiation
KM400_RS12120	COG0768	penicillin binding
KM400_RS12125	COG0768	penicillin binding
KM400_RS12130	COG2367	Beta-lactamase
KM400_RS12135	COG0671	phosphoesterase, PA-phosphatase related
KM400_RS12140	COG1609	Transcriptional regulator
KM400_RS12150	COG0673	inositol 2-dehydrogenase activity
KM400_RS12160	COG1012	belongs to the aldehyde dehydrogenase family
KM400_RS12175	COG0191	fructose-bisphosphate aldolase activity
KM400_RS12195	COG0737	Belongs to the 5'-nucleotidase family
KM400_RS12205	COG0457	Tetratricopeptide repeat
KM400_RS12210	COG1476	TRANSCRIPTIONal
KM400_RS12225	COG1876	peptidase activity
KM400_RS12245	COG1309	transcriptional regulator
KM400_RS12250	COG0488	(ABC) transporter
KM400_RS12265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM400_RS12300	COG1131	(ABC) transporter
KM400_RS12310	COG1309	transcriptional regulator
KM400_RS12325	COG1960	acyl-CoA dehydrogenase activity
KM400_RS12330	COG0439	Biotin carboxylase
KM400_RS12335	COG0511	ligase activity, forming carbon-carbon bonds
KM400_RS12340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KM400_RS12345	COG1024	Enoyl-CoA hydratase
KM400_RS12350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KM400_RS12355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM400_RS12365	COG1247	-acetyltransferase
KM400_RS12370	COG0572	uridine kinase
KM400_RS12380	COG2318	DinB family
KM400_RS12385	COG1686	Belongs to the peptidase S11 family
KM400_RS12410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KM400_RS12450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM400_RS12450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM400_RS12475	COG2814	Major facilitator Superfamily
KM400_RS12495	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM400_RS12515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM400_RS12530	COG1063	alcohol dehydrogenase
KM400_RS12545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM400_RS12550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM400_RS12565	COG3773	Cell wall hydrolase
KM400_RS12575	COG0745	RESPONSE REGULATOR receiver
KM400_RS12590	COG0488	(ABC) transporter
KM400_RS12605	COG1136	(ABC) transporter
KM400_RS12630	COG0460	homoserine dehydrogenase
KM400_RS12635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM400_RS12645	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM400_RS12710	COG2124	cytochrome p450
KM400_RS12745	COG0561	phosphatase activity
KM400_RS12755	COG0768	penicillin binding
KM400_RS12760	COG1819	glycosyl
KM400_RS12765	COG1794	racemase activity, acting on amino acids and derivatives
KM400_RS12775	COG1122	ATPase activity
KM400_RS12790	COG2205	protein histidine kinase activity
KM400_RS12800	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM400_RS12805	COG0604	alcohol dehydrogenase
KM400_RS12810	COG0768	penicillin binding
KM400_RS12820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM400_RS12855	COG0693	protein deglycase activity
KM400_RS12885	COG2814	Major facilitator Superfamily
KM400_RS12900	COG0584	glycerophosphoryl diester phosphodiesterase
KM400_RS12950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM400_RS12960	COG2223	nitrite transmembrane transporter activity
KM400_RS12975	COG2816	NAD+ diphosphatase activity
KM400_RS12980	COG0592	DNA-directed DNA polymerase activity
KM400_RS12985	COG1051	belongs to the nudix hydrolase family
KM400_RS13020	COG3878	Protein conserved in bacteria
KM400_RS13070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM400_RS13085	COG0322	excinuclease ABC activity
KM400_RS13125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM400_RS13150	COG1011	Hydrolase
KM400_RS13165	COG0657	acetylesterase activity
KM400_RS13170	COG0076	glutamate decarboxylase activity
KM400_RS13185	COG1523	belongs to the glycosyl hydrolase 13 family
KM400_RS13190	COG3227	Zinc metalloprotease (Elastase)
KM400_RS13210	COG0201	protein transport
KM400_RS13220	COG0697	spore germination
KM400_RS13225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM400_RS13255	COG4129	membrane
KM400_RS13260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM400_RS13275	COG2959	enzyme of heme biosynthesis
KM400_RS13295	COG3483	tryptophan 2,3-dioxygenase activity
KM400_RS13300	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KM400_RS13305	COG3844	kynureninase activity
KM400_RS13310	COG1309	transcriptional regulator
KM400_RS13340	COG3284	Transcriptional regulator
KM400_RS13360	COG1349	DNA-binding transcription factor activity
KM400_RS13380	COG1959	2 iron, 2 sulfur cluster binding
KM400_RS13395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM400_RS13400	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM400_RS13405	COG0022	dehydrogenase e1 component
KM400_RS13410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM400_RS13420	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS13425	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM400_RS13425	COG0456	acetyltransferase
KM400_RS13455	COG4176	ABC-type proline glycine betaine transport system permease component
KM400_RS13460	COG0517	IMP dehydrogenase activity
KM400_RS13460	COG4175	Glycine betaine
KM400_RS13485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KM400_RS13490	COG2153	protein acetylation
KM400_RS13495	COG3397	chitin binding
KM400_RS13510	COG2205	protein histidine kinase activity
KM400_RS13535	COG0658	competence protein
KM400_RS13535	COG2333	competence protein COMEC
KM400_RS13585	COG3973	AAA domain
KM400_RS13600	COG2105	PFAM AIG2 family protein
KM400_RS13605	COG0514	ATP-dependent DNA helicase (RecQ)
KM400_RS13625	COG4637	Psort location Cytoplasmic, score
KM400_RS13650	COG3397	chitin binding
KM400_RS13665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KM400_RS13670	COG1115	amino acid carrier protein
KM400_RS13675	COG1012	belongs to the aldehyde dehydrogenase family
KM400_RS13680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM400_RS13690	COG3938	Belongs to the proline racemase family
KM400_RS13695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM400_RS13735	COG0586	Pfam SNARE associated Golgi protein
KM400_RS13750	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM400_RS13755	COG0519	Catalyzes the synthesis of GMP from XMP
KM400_RS13760	COG4166	transmembrane transport
KM400_RS13770	COG4948	Mandelate Racemase Muconate Lactonizing
KM400_RS13815	COG2936	dipeptidyl-peptidase activity
KM400_RS13820	COG5002	protein histidine kinase activity
KM400_RS13825	COG0745	RESPONSE REGULATOR receiver
KM400_RS13870	COG1307	EDD domain protein, DegV family
KM400_RS13890	COG2814	Major facilitator Superfamily
KM400_RS13900	COG1664	Polymer-forming cytoskeletal
KM400_RS13905	COG0789	Transcriptional regulator
KM400_RS13910	COG4533	DNA binding
KM400_RS13915	COG2814	Major facilitator Superfamily
KM400_RS13915	COG0477	Major facilitator Superfamily
KM400_RS13935	COG2261	transglycosylase associated protein
KM400_RS13950	COG2226	methyltransferase
KM400_RS13985	COG0436	Aminotransferase
KM400_RS13990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KM400_RS13995	COG5146	pantothenate kinase activity
KM400_RS14015	COG1131	(ABC) transporter
KM400_RS14060	COG0628	permease
KM400_RS14075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM400_RS14080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM400_RS14085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM400_RS14090	COG1116	anion transmembrane transporter activity
KM400_RS14110	COG2816	NAD+ diphosphatase activity
KM400_RS14130	COG2746	aminoglycoside 3-N-acetyltransferase activity
KM400_RS14155	COG0697	spore germination
KM400_RS14160	COG2318	DinB family
KM400_RS14180	COG4912	Dna alkylation repair
KM400_RS14200	COG0861	Integral membrane protein TerC family
KM400_RS14205	COG1368	sulfuric ester hydrolase activity
KM400_RS14210	COG0488	(ABC) transporter
KM400_RS14225	COG1309	transcriptional regulator
KM400_RS14240	COG0287	Prephenate dehydrogenase
KM400_RS14245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM400_RS14250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KM400_RS14255	COG1605	Chorismate mutase
KM400_RS14255	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KM400_RS14290	COG3584	3D domain protein
KM400_RS14290	COG1388	LysM domain
KM400_RS14300	COG1595	DNA-templated transcription, initiation
KM400_RS14325	COG1879	ABC-type sugar transport system periplasmic component
KM400_RS14335	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM400_RS14345	COG2390	Transcriptional regulator
KM400_RS14350	COG1070	Carbohydrate kinase
KM400_RS14380	COG2329	Antibiotic biosynthesis monooxygenase
KM400_RS14400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM400_RS14410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KM400_RS14415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM400_RS14420	COG4187	Peptidase family M20/M25/M40
KM400_RS14425	COG1414	Transcriptional regulator
KM400_RS14430	COG0833	amino acid
KM400_RS14435	COG1690	Belongs to the RtcB family
KM400_RS14440	COG3239	Fatty acid desaturase
KM400_RS14445	COG1785	Belongs to the alkaline phosphatase family
KM400_RS14455	COG3655	Transcriptional regulator
KM400_RS14470	COG4377	Putative membrane peptidase family (DUF2324)
KM400_RS14480	COG3279	Response regulator of the LytR AlgR family
KM400_RS14490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM400_RS14495	COG0346	lactoylglutathione lyase activity
KM400_RS14515	COG0714	Associated with various cellular activities
KM400_RS14540	COG0463	Glycosyl transferase, family 2
KM400_RS14560	COG0463	Glycosyl transferase, family 2
KM400_RS14570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM400_RS14575	COG0753	catalase activity
KM400_RS14585	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KM400_RS14610	COG0714	Associated with various cellular activities
KM400_RS14620	COG0778	Nitroreductase
KM400_RS14625	COG1846	Transcriptional regulator
KM400_RS14660	COG1725	Transcriptional regulator
KM400_RS14670	COG0577	efflux transmembrane transporter activity
KM400_RS14670	COG1136	(ABC) transporter
KM400_RS14695	COG2207	Transcriptional regulator
KM400_RS14700	COG0456	acetyltransferase
KM400_RS14720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM400_RS14740	COG0642	Histidine kinase
KM400_RS14745	COG0745	RESPONSE REGULATOR receiver
KM400_RS14750	COG0596	Alpha beta hydrolase
KM400_RS14780	COG0730	response to heat
KM400_RS14790	COG0833	amino acid
KM400_RS14800	COG4335	DNA alkylation repair
KM400_RS14840	COG0768	penicillin binding
KM400_RS14850	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KM400_RS14885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KM400_RS14890	COG1414	Transcriptional regulator
KM400_RS14905	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM400_RS14910	COG0640	Transcriptional regulator
KM400_RS14920	COG1960	acyl-CoA dehydrogenase activity
KM400_RS14935	COG3314	Sporulation integral membrane protein YlbJ
KM400_RS14950	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KM400_RS14965	COG0574	Belongs to the PEP-utilizing enzyme family
KM400_RS14965	COG3848	Pyruvate phosphate dikinase
KM400_RS14970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM400_RS14985	COG5577	PFAM Coat F domain
KM400_RS14990	COG3403	YqcI/YcgG family
KM400_RS14995	COG1280	lysine exporter protein (LysE YggA)
KM400_RS15030	COG1063	alcohol dehydrogenase
KM400_RS15045	COG1027	Aspartate ammonia-lyase
KM400_RS15050	COG0252	asparaginase activity
KM400_RS15055	COG1396	sequence-specific DNA binding
KM400_RS15065	COG0322	excinuclease ABC activity
KM400_RS15070	COG0531	amino acid
KM400_RS15075	COG1114	Component of the transport system for branched-chain amino acids
KM400_RS15080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM400_RS15090	COG0281	malic enzyme
KM400_RS15105	COG0531	amino acid
KM400_RS15115	COG0784	Response regulator, receiver
KM400_RS15125	COG2066	Belongs to the glutaminase family
KM400_RS15130	COG1115	amino acid carrier protein
KM400_RS15160	COG0737	Belongs to the 5'-nucleotidase family
KM400_RS15165	COG0753	catalase activity
KM400_RS15170	COG2267	carboxylic ester hydrolase activity
KM400_RS15175	COG1335	isochorismatase
KM400_RS15195	COG0583	DNA-binding transcription factor activity
KM400_RS15205	COG0598	Magnesium transport protein CorA
KM400_RS15245	COG0415	Belongs to the DNA photolyase family
KM400_RS15250	COG0288	reversible hydration of carbon dioxide
KM400_RS15260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM400_RS15265	COG5609	conserved protein (DUF2294)
KM400_RS15280	COG1575	Belongs to the MenA family. Type 1 subfamily
KM400_RS15285	COG2267	carboxylic ester hydrolase activity
KM400_RS15290	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM400_RS15295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM400_RS15300	COG1121	(ABC) transporter
KM400_RS15330	COG0798	PFAM Bile acid sodium symporter
KM400_RS15335	COG0346	lactoylglutathione lyase activity
KM400_RS15340	COG0640	Transcriptional regulator
KM400_RS15355	COG0443	Heat shock 70 kDa protein
KM400_RS15370	COG1522	sequence-specific DNA binding
KM400_RS15385	COG0346	lactoylglutathione lyase activity
KM400_RS15405	COG2169	Transcriptional regulator
KM400_RS15450	COG2814	Major facilitator Superfamily
KM400_RS15475	COG0745	RESPONSE REGULATOR receiver
KM400_RS15480	COG3850	Histidine kinase
KM400_RS15480	COG5002	protein histidine kinase activity
KM400_RS15505	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KM400_RS15525	COG1476	TRANSCRIPTIONal
KM400_RS15540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM400_RS15545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM400_RS15555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM400_RS15560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KM400_RS15575	COG1136	(ABC) transporter
KM400_RS15580	COG0577	efflux transmembrane transporter activity
KM400_RS15595	COG5002	protein histidine kinase activity
KM400_RS15595	COG3850	Histidine kinase
KM400_RS15605	COG2364	Membrane
KM400_RS15610	COG1846	Transcriptional regulator
KM400_RS15620	COG2808	Putative FMN-binding domain
KM400_RS15625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM400_RS15630	COG2271	Major facilitator Superfamily
KM400_RS15635	COG1556	Lactate utilization protein
KM400_RS15640	COG1139	Iron-sulfur cluster binding protein
KM400_RS15650	COG0583	DNA-binding transcription factor activity
KM400_RS15660	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM400_RS15690	COG0673	inositol 2-dehydrogenase activity
KM400_RS15695	COG0561	phosphatase activity
KM400_RS15705	COG1609	Transcriptional regulator
KM400_RS15710	COG0457	Tetratricopeptide repeat
KM400_RS15730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM400_RS15760	COG0534	Mate efflux family protein
KM400_RS15780	COG2814	Major facilitator Superfamily
KM400_RS15785	COG1309	transcriptional regulator
KM400_RS15800	COG0814	amino acid
KM400_RS15805	COG1760	l-serine dehydratase
KM400_RS15820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM400_RS15825	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KM400_RS15840	COG1522	sequence-specific DNA binding
KM400_RS15845	COG0531	amino acid
KM400_RS15865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KM400_RS15885	COG1595	DNA-templated transcription, initiation
KM400_RS15900	COG0662	Cupin 2, conserved barrel domain protein
KM400_RS15905	COG2207	Transcriptional regulator
KM400_RS15905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM400_RS15955	COG0477	Major facilitator Superfamily
KM400_RS15965	COG1846	Transcriptional regulator
KM400_RS15970	COG2814	Major facilitator Superfamily
KM400_RS15980	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM400_RS15985	COG1131	(ABC) transporter
KM400_RS16005	COG2076	Multidrug Resistance protein
KM400_RS16010	COG1309	transcriptional regulator
KM400_RS16020	COG2031	fatty acid transporter
KM400_RS16030	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM400_RS16060	COG1122	ATPase activity
KM400_RS16065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM400_RS16080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KM400_RS16085	COG1288	antiporter activity
KM400_RS16090	COG2356	endonuclease I
KM400_RS16105	COG3620	sequence-specific DNA binding
KM400_RS16110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM400_RS16115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KM400_RS16120	COG0124	histidyl-tRNA synthetase
KM400_RS16135	COG1733	regulation of RNA biosynthetic process
KM400_RS16140	COG0778	Nitroreductase
KM400_RS16160	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS16170	COG1131	(ABC) transporter
KM400_RS16195	COG1011	Hydrolase
KM400_RS16205	COG2365	Tyrosine phosphatase family
KM400_RS16230	COG0346	lactoylglutathione lyase activity
KM400_RS16235	COG1940	carbohydrate kinase activity
KM400_RS16240	COG0738	Major facilitator superfamily
KM400_RS16245	COG0110	maltose O-acetyltransferase activity
KM400_RS16255	COG0577	efflux transmembrane transporter activity
KM400_RS16255	COG1136	(ABC) transporter
KM400_RS16270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KM400_RS16275	COG0628	permease
KM400_RS16295	COG2226	methyltransferase
KM400_RS16305	COG0477	Major facilitator Superfamily
KM400_RS16335	COG1253	flavin adenine dinucleotide binding
KM400_RS16340	COG0789	Transcriptional regulator
KM400_RS16345	COG0697	spore germination
KM400_RS16350	COG1357	PFAM Pentapeptide repeats (8 copies)
KM400_RS16355	COG3813	Protein conserved in bacteria
KM400_RS16360	COG2706	6-phosphogluconolactonase activity
KM400_RS16365	COG1070	Carbohydrate kinase
KM400_RS16375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KM400_RS16380	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KM400_RS16390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM400_RS16395	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM400_RS16400	COG0604	alcohol dehydrogenase
KM400_RS16405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM400_RS16415	COG3321	synthase
KM400_RS16415	COG0604	alcohol dehydrogenase
KM400_RS16420	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS16445	COG0656	L-ascorbic acid biosynthetic process
KM400_RS16450	COG2814	Major facilitator Superfamily
KM400_RS16465	COG0346	lactoylglutathione lyase activity
KM400_RS16470	COG0814	amino acid
KM400_RS16495	COG1393	Belongs to the ArsC family
KM400_RS16500	COG1733	regulation of RNA biosynthetic process
KM400_RS16505	COG2188	Transcriptional regulator
KM400_RS16510	COG0673	inositol 2-dehydrogenase activity
KM400_RS16515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KM400_RS16520	COG1733	regulation of RNA biosynthetic process
KM400_RS16525	COG1733	regulation of RNA biosynthetic process
KM400_RS16540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM400_RS16560	COG0384	phenazine biosynthesis protein PhzF
KM400_RS16570	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS16580	COG0318	PFAM AMP-dependent synthetase and ligase
KM400_RS16590	COG1733	regulation of RNA biosynthetic process
KM400_RS16620	COG1191	sigma factor activity
KM400_RS16635	COG1309	transcriptional regulator
KM400_RS16655	COG3152	Membrane
KM400_RS16680	COG1151	hydroxylamine reductase activity
KM400_RS16690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM400_RS16695	COG3409	Peptidoglycan-binding domain 1 protein
KM400_RS16695	COG3757	hydrolase, family 25
KM400_RS16730	COG2072	flavoprotein involved in K transport
KM400_RS16765	COG0604	alcohol dehydrogenase
KM400_RS16770	COG1113	amino acid transport
KM400_RS16775	COG2814	Major facilitator Superfamily
KM400_RS16805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM400_RS16810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM400_RS16835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM400_RS16840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM400_RS16845	COG3739	integral membrane protein
KM400_RS16850	COG0384	phenazine biosynthesis protein PhzF
KM400_RS16880	COG0583	DNA-binding transcription factor activity
KM400_RS16900	COG1193	negative regulation of DNA recombination
KM400_RS16915	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KM400_RS16920	COG1164	Oligoendopeptidase f
KM400_RS16925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM400_RS16955	COG0584	glycerophosphoryl diester phosphodiesterase
KM400_RS16980	COG0640	Transcriptional regulator
KM400_RS16985	COG0604	alcohol dehydrogenase
KM400_RS17005	COG2808	Putative FMN-binding domain
KM400_RS17020	COG0385	Bile acid
KM400_RS17025	COG0277	FAD linked oxidase domain protein
KM400_RS17055	COG1216	Glycosyl transferase, family 2
KM400_RS17060	COG1024	Enoyl-CoA hydratase
KM400_RS17070	COG1285	pathogenesis
KM400_RS17085	COG2514	catechol 2,3-dioxygenase activity
KM400_RS17090	COG2720	vancomycin resistance protein
KM400_RS17130	COG0716	FMN binding
KM400_RS17160	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS17185	COG4145	pantothenate transmembrane transporter activity
KM400_RS17195	COG1012	belongs to the aldehyde dehydrogenase family
KM400_RS17200	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS17210	COG1657	PFAM Prenyltransferase squalene oxidase
KM400_RS17215	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KM400_RS17220	COG2962	Rard protein
KM400_RS17225	COG3326	Membrane
KM400_RS17240	COG0489	protein tyrosine kinase activity
KM400_RS17250	COG0314	molybdopterin synthase activity
KM400_RS17255	COG0303	'Molybdopterin
KM400_RS17260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM400_RS17265	COG2116	formate transmembrane transporter activity
KM400_RS17275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM400_RS17280	COG5609	conserved protein (DUF2294)
KM400_RS17285	COG2427	Protein of unknown function (DUF1641)
KM400_RS17290	COG3383	formate dehydrogenase (NAD+) activity
KM400_RS17300	COG0697	spore germination
KM400_RS17340	COG2226	methyltransferase
KM400_RS17345	COG4166	transmembrane transport
KM400_RS17350	COG4166	transmembrane transport
KM400_RS17355	COG1301	dicarboxylic acid transport
KM400_RS17360	COG1316	TRANSCRIPTIONal
KM400_RS17370	COG1595	DNA-templated transcription, initiation
KM400_RS17390	COG1131	(ABC) transporter
KM400_RS17400	COG0673	inositol 2-dehydrogenase activity
KM400_RS17405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM400_RS17410	COG0187	DNA topoisomerase II activity
KM400_RS17415	COG1832	CoA-binding protein
KM400_RS17420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM400_RS17425	COG0745	RESPONSE REGULATOR receiver
KM400_RS17440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM400_RS17445	COG4841	protein insertion into membrane
KM400_RS17450	COG0824	Thioesterase
KM400_RS17480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM400_RS17490	COG2274	protein secretion by the type I secretion system
KM400_RS17495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KM400_RS17535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM400_RS17550	COG0183	Belongs to the thiolase family
KM400_RS17555	COG0318	PFAM AMP-dependent synthetase and ligase
KM400_RS17560	COG1268	BioY protein
KM400_RS17565	COG0318	PFAM AMP-dependent synthetase and ligase
KM400_RS17615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM400_RS17625	COG5002	protein histidine kinase activity
KM400_RS17630	COG0400	carboxylic ester hydrolase activity
KM400_RS17635	COG0346	lactoylglutathione lyase activity
KM400_RS17640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM400_RS17645	COG0069	glutamate synthase activity
KM400_RS17650	COG1902	pentaerythritol trinitrate reductase activity
KM400_RS17655	COG1329	Transcriptional regulator
KM400_RS17660	COG0010	Belongs to the arginase family
KM400_RS17685	COG2226	methyltransferase
KM400_RS17720	COG4846	Membrane protein involved in cytochrome C biogenesis
KM400_RS17725	COG0785	Cytochrome C biogenesis protein
KM400_RS17735	COG0583	DNA-binding transcription factor activity
KM400_RS17740	COG1380	Effector of murein hydrolase LrgA
KM400_RS17745	COG1346	cytolysis
KM400_RS17770	COG3409	Peptidoglycan-binding domain 1 protein
KM400_RS17770	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM400_RS17785	COG1132	(ABC) transporter
KM400_RS17790	COG1132	(ABC) transporter
KM400_RS17820	COG3639	organic phosphonate transmembrane transporter activity
KM400_RS17825	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KM400_RS17845	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KM400_RS17865	COG1695	Transcriptional regulator
KM400_RS17905	COG1388	LysM domain
KM400_RS17905	COG3409	Peptidoglycan-binding domain 1 protein
KM400_RS17905	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM400_RS17910	COG4824	toxin secretion phage lysis holin
KM400_RS18055	COG1595	DNA-templated transcription, initiation
KM400_RS18100	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KM400_RS18185	COG1396	sequence-specific DNA binding
KM400_RS18210	COG0174	glutamine synthetase
KM400_RS18215	COG0789	Transcriptional regulator
KM400_RS18220	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KM400_RS18225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM400_RS18230	COG2860	membrane
KM400_RS18235	COG0464	growth
KM400_RS18265	COG3584	3D domain protein
KM400_RS18265	COG1388	LysM domain
KM400_RS18270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM400_RS18270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM400_RS18270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM400_RS18275	COG1105	Belongs to the carbohydrate kinase PfkB family
KM400_RS18280	COG1349	DNA-binding transcription factor activity
KM400_RS18290	COG2322	membrane
KM400_RS18300	COG1113	amino acid transport
KM400_RS18315	COG1408	metallophosphoesterase
KM400_RS18320	COG2116	formate transmembrane transporter activity
KM400_RS18330	COG2217	Heavy metal translocating P-type atpase
KM400_RS18335	COG2608	mercury ion transmembrane transporter activity
KM400_RS18340	COG1937	Protein conserved in bacteria
KM400_RS18350	COG2819	hydrolase of the alpha beta superfamily
KM400_RS18355	COG1120	ATPase activity
KM400_RS18360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM400_RS18365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM400_RS18380	COG2169	Transcriptional regulator
KM400_RS18385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM400_RS18390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM400_RS18400	COG2364	Membrane
KM400_RS18420	COG0346	lactoylglutathione lyase activity
KM400_RS18445	COG1346	cytolysis
KM400_RS18450	COG1380	Effector of murein hydrolase LrgA
KM400_RS18455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM400_RS18460	COG0596	Alpha beta hydrolase
KM400_RS18460	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM400_RS18465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM400_RS18485	COG1404	Belongs to the peptidase S8 family
KM400_RS18490	COG3773	Cell wall hydrolase
KM400_RS18495	COG0562	UDP-galactopyranose mutase
KM400_RS18500	COG1368	sulfuric ester hydrolase activity
KM400_RS18505	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM400_RS18515	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KM400_RS18540	COG1131	(ABC) transporter
KM400_RS18560	COG4550	Control of competence regulator ComK, YlbF/YmcA
KM400_RS18565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM400_RS18570	COG1013	pyruvate-flavodoxin oxidoreductase activity
KM400_RS18575	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KM400_RS18575	COG0674	pyruvate-flavodoxin oxidoreductase activity
KM400_RS18585	COG2359	stage V sporulation protein S
KM400_RS18590	COG1692	metallophosphoesterase
KM400_RS18615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM400_RS18620	COG1426	Protein conserved in bacteria
KM400_RS18635	COG0300	oxidoreductase activity
KM400_RS18640	COG0612	Peptidase, M16
KM400_RS18645	COG0612	Peptidase, M16
KM400_RS18650	COG1079	Belongs to the binding-protein-dependent transport system permease family
KM400_RS18660	COG3845	ABC transporter
KM400_RS18665	COG1744	ABC transporter substrate-binding protein PnrA-like
KM400_RS18670	COG2188	Transcriptional regulator
KM400_RS18675	COG1674	ftsk spoiiie
KM400_RS18685	COG0740	serine-type endopeptidase activity
KM400_RS18690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM400_RS18700	COG0527	aspartate kinase activity
KM400_RS18705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM400_RS18710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM400_RS18715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM400_RS18720	COG1873	PFAM PRC-barrel domain
KM400_RS18725	COG0612	Peptidase, M16
KM400_RS18730	COG0726	polysaccharide deacetylase
KM400_RS18745	COG0196	riboflavin kinase activity
KM400_RS18750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KM400_RS18760	COG1550	Protein conserved in bacteria
KM400_RS18770	COG1358	cellular component organization or biogenesis
KM400_RS18775	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KM400_RS18780	COG0195	Participates in both transcription termination and antitermination
KM400_RS18800	COG0750	zinc metalloprotease
KM400_RS18810	COG4589	Belongs to the CDS family
KM400_RS18825	COG0528	UMP kinase activity
KM400_RS18855	COG4974	Belongs to the 'phage' integrase family
KM400_RS18865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM400_RS18875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KM400_RS18915	COG1837	Belongs to the UPF0109 family
KM400_RS18925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KM400_RS18935	COG0552	protein localization to endoplasmic reticulum
KM400_RS18940	COG1196	nuclear chromosome segregation
KM400_RS18950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM400_RS18955	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS18960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KM400_RS18975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KM400_RS18980	COG1461	Dihydroxyacetone kinase
KM400_RS18985	COG1302	Protein conserved in bacteria
KM400_RS19000	COG1564	THIamine pyrophosphokinase
KM400_RS19005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KM400_RS19010	COG1162	GTPase activity
KM400_RS19015	COG2815	serine threonine protein kinase
KM400_RS19015	COG0515	serine threonine protein kinase
KM400_RS19020	COG0631	protein serine/threonine phosphatase activity
KM400_RS19030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KM400_RS19030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM400_RS19040	COG0242	peptide deformylase activity
KM400_RS19045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KM400_RS19050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM400_RS19070	COG1561	YicC-like family, N-terminal region
KM400_RS19075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KM400_RS19085	COG0006	proline dipeptidase activity
KM400_RS19100	COG3069	C4-dicarboxylate transmembrane transporter activity
KM400_RS19165	COG0564	pseudouridine synthase activity
KM400_RS19185	COG3599	regulation of cell shape
KM400_RS19190	COG2302	S4 RNA-binding domain
KM400_RS19195	COG0762	integral membrane protein
KM400_RS19205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KM400_RS19210	COG1496	oxidoreductase activity
KM400_RS19215	COG1873	PFAM PRC-barrel domain
KM400_RS19220	COG1191	sigma factor activity
KM400_RS19225	COG1191	sigma factor activity
KM400_RS19235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KM400_RS19240	COG0849	cell division
KM400_RS19245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KM400_RS19250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM400_RS19260	COG0772	Belongs to the SEDS family
KM400_RS19275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM400_RS19280	COG0768	penicillin binding
KM400_RS19285	COG0768	penicillin binding
KM400_RS19290	COG4839	cell division protein FtsL
KM400_RS19305	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM400_RS19320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KM400_RS19325	COG1399	metal-binding, possibly nucleic acid-binding protein
KM400_RS19375	COG4824	toxin secretion phage lysis holin
KM400_RS19465	COG1802	Transcriptional regulator
KM400_RS19465	COG4626	Terminase
KM400_RS19490	COG0582	viral genome integration into host DNA
KM400_RS19555	COG0756	dUTP diphosphatase activity
KM400_RS19570	COG1191	sigma factor activity
KM400_RS19595	COG1484	DNA-dependent DNA replication
KM400_RS19620	COG1396	sequence-specific DNA binding
KM400_RS19635	COG1396	sequence-specific DNA binding
KM400_RS19650	COG0582	viral genome integration into host DNA
KM400_RS19660	COG3480	Lon protease (S16) C-terminal proteolytic domain
KM400_RS19665	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM400_RS19670	COG3314	Sporulation integral membrane protein YlbJ
KM400_RS19680	COG0742	ribosomal rna small subunit methyltransferase
KM400_RS19695	COG3679	Belongs to the UPF0342 family
KM400_RS19700	COG0406	alpha-ribazole phosphatase activity
KM400_RS19715	COG2340	Cysteine-rich secretory protein family
KM400_RS19730	COG3336	cytochrome c oxidase
KM400_RS19765	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KM400_RS19770	COG0772	Belongs to the SEDS family
KM400_RS19780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KM400_RS19785	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KM400_RS19795	COG4896	Protein conserved in bacteria
KM400_RS19810	COG1217	gtp-binding protein TYPA
KM400_RS19820	COG0483	inositol monophosphate 1-phosphatase activity
KM400_RS19840	COG1982	Orn Lys Arg decarboxylase major
KM400_RS19890	COG0022	dehydrogenase e1 component
KM400_RS19895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM400_RS19905	COG0242	peptide deformylase activity
KM400_RS19920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM400_RS19925	COG0569	domain protein
KM400_RS19945	COG0583	DNA-binding transcription factor activity
KM400_RS19950	COG0517	IMP dehydrogenase activity
KM400_RS19960	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KM400_RS19970	COG4703	Protein of unknown function (DUF1797)
KM400_RS19985	COG2200	EAL domain
KM400_RS19990	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS19995	COG1408	metallophosphoesterase
KM400_RS20040	COG2814	Major facilitator Superfamily
KM400_RS20060	COG3209	COG3209 Rhs family protein
KM400_RS20070	COG2205	protein histidine kinase activity
KM400_RS20080	COG0436	Aminotransferase
KM400_RS20085	COG1609	Transcriptional regulator
KM400_RS20090	COG3833	ABC-type maltose transport systems, permease component
KM400_RS20095	COG1175	transmembrane transport
KM400_RS20100	COG2182	Extracellular solute-binding protein
KM400_RS20110	COG0366	Alpha amylase catalytic
KM400_RS20115	COG3842	ATPase activity
KM400_RS20155	COG0183	Belongs to the thiolase family
KM400_RS20190	COG1695	Transcriptional regulator
KM400_RS20195	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS20205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KM400_RS20215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM400_RS20220	COG0436	Aminotransferase
KM400_RS20240	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KM400_RS20260	COG2199	diguanylate cyclase activity
KM400_RS20265	COG0778	Nitroreductase
KM400_RS20290	COG1263	PTS System
KM400_RS20290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM400_RS20290	COG2190	(PTS) system
KM400_RS20295	COG3711	transcriptional antiterminator
KM400_RS20305	COG2188	Transcriptional regulator
KM400_RS20315	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KM400_RS20340	COG1547	Domain of unknown function (DUF309)
KM400_RS20345	COG0456	acetyltransferase
KM400_RS20355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KM400_RS20360	COG4086	secreted protein
KM400_RS20365	COG0561	phosphatase activity
KM400_RS20370	COG0697	spore germination
KM400_RS20385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM400_RS20410	COG0733	neurotransmitter:sodium symporter activity
KM400_RS20430	COG1686	Belongs to the peptidase S11 family
KM400_RS20435	COG1725	Transcriptional regulator
KM400_RS20440	COG1131	(ABC) transporter
KM400_RS20455	COG1846	Transcriptional regulator
KM400_RS20470	COG0598	Magnesium transport protein CorA
KM400_RS20495	COG4974	Belongs to the 'phage' integrase family
KM400_RS20505	COG0735	belongs to the Fur family
KM400_RS20510	COG1300	Membrane
KM400_RS20530	COG0667	Aldo Keto reductase
KM400_RS20535	COG0656	L-ascorbic acid biosynthetic process
KM400_RS20540	COG0456	acetyltransferase
KM400_RS20540	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM400_RS20550	COG4085	toxin activity
KM400_RS20550	COG1525	nuclease
KM400_RS20550	COG0737	Belongs to the 5'-nucleotidase family
KM400_RS20560	COG0596	Alpha beta hydrolase
KM400_RS20565	COG2056	Na+-H+ antiporter family
KM400_RS20570	COG1609	Transcriptional regulator
KM400_RS20575	COG0456	acetyltransferase
KM400_RS20580	COG1073	alpha beta
KM400_RS20595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM400_RS20595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM400_RS20600	COG0307	riboflavin synthase, alpha
KM400_RS20625	COG4106	trans-aconitate 2-methyltransferase activity
KM400_RS20630	COG1073	alpha beta
KM400_RS20630	COG2226	methyltransferase
KM400_RS20645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM400_RS20655	COG1757	Na H antiporter
KM400_RS20660	COG0737	Belongs to the 5'-nucleotidase family
KM400_RS20670	COG1522	sequence-specific DNA binding
KM400_RS20690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM400_RS20700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KM400_RS20715	COG0300	oxidoreductase activity
KM400_RS20720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM400_RS20725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM400_RS20730	COG1760	l-serine dehydratase
KM400_RS20735	COG1760	l-serine dehydratase
KM400_RS20755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM400_RS20765	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM400_RS20770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM400_RS20785	COG1376	ErfK ybiS ycfS ynhG family protein
KM400_RS20790	COG4129	membrane
KM400_RS20795	COG1126	abc transporter atp-binding protein
KM400_RS20800	COG0765	amino acid transport
KM400_RS20805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM400_RS20820	COG2816	NAD+ diphosphatase activity
KM400_RS20825	COG0772	Belongs to the SEDS family
KM400_RS20830	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM400_RS20835	COG0022	dehydrogenase e1 component
KM400_RS20840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM400_RS20845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM400_RS20860	COG0280	phosphate acetyltransferase
KM400_RS20865	COG3290	protein histidine kinase activity
KM400_RS20865	COG3829	transcription factor binding
KM400_RS20875	COG0584	glycerophosphoryl diester phosphodiesterase
KM400_RS20880	COG3093	addiction module antidote protein HigA
KM400_RS20890	COG0745	RESPONSE REGULATOR receiver
KM400_RS20895	COG0750	zinc metalloprotease
KM400_RS20900	COG0497	DNA recombination
KM400_RS20910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KM400_RS20920	COG0142	geranyltranstransferase activity
KM400_RS20945	COG1302	Protein conserved in bacteria
KM400_RS20950	COG0439	Biotin carboxylase
KM400_RS20955	COG0511	ligase activity, forming carbon-carbon bonds
KM400_RS21000	COG3854	ATPases associated with a variety of cellular activities
KM400_RS21025	COG0006	proline dipeptidase activity
KM400_RS21040	COG3872	metal-dependent enzyme
KM400_RS21050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM400_RS21070	COG0095	Lipoate-protein ligase
KM400_RS21075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM400_RS21080	COG1609	Transcriptional regulator
KM400_RS21090	COG2076	Multidrug Resistance protein
KM400_RS21095	COG2076	Multidrug Resistance protein
KM400_RS21130	COG1131	(ABC) transporter
KM400_RS21135	COG1725	Transcriptional regulator
KM400_RS21165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM400_RS21220	COG4970	Tfp pilus assembly protein FimT
KM400_RS21230	COG1459	type II secretion system
KM400_RS21235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM400_RS21285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KM400_RS21295	COG0646	methionine synthase
KM400_RS21295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KM400_RS21300	COG0626	cystathionine gamma-synthase activity
KM400_RS21305	COG0626	cystathionine gamma-synthase activity
KM400_RS21325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM400_RS21335	COG1940	carbohydrate kinase activity
KM400_RS21340	COG4483	Protein conserved in bacteria
KM400_RS21345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KM400_RS21350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KM400_RS21355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KM400_RS21360	COG0704	Plays a role in the regulation of phosphate uptake
KM400_RS21370	COG0581	inorganic phosphate transmembrane transporter activity
KM400_RS21375	COG0573	inorganic phosphate transmembrane transporter activity
KM400_RS21380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM400_RS21385	COG0768	penicillin binding
KM400_RS21390	COG0477	Major facilitator Superfamily
KM400_RS21395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM400_RS21420	COG0735	belongs to the Fur family
KM400_RS21425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM400_RS21430	COG1121	(ABC) transporter
KM400_RS21435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM400_RS21465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM400_RS21470	COG2384	SAM-dependent methyltransferase
KM400_RS21475	COG2010	Cytochrome c
KM400_RS21480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM400_RS21485	COG0358	DNA primase activity
KM400_RS21500	COG0517	IMP dehydrogenase activity
KM400_RS21515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KM400_RS21520	COG0295	cytidine deaminase activity
KM400_RS21525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KM400_RS21535	COG1480	7TM receptor with intracellular HD hydrolase
KM400_RS21540	COG1702	phosphate starvation-inducible protein PhoH
KM400_RS21555	COG1610	YqeY-like protein
KM400_RS21560	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KM400_RS21565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM400_RS21570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KM400_RS21600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM400_RS21605	COG1733	regulation of RNA biosynthetic process
KM400_RS21630	COG1466	dna polymerase III delta subunit
KM400_RS21640	COG2333	competence protein COMEC
KM400_RS21640	COG0658	competence protein
KM400_RS21645	COG2131	deaminase
KM400_RS21650	COG1555	photosystem II stabilization
KM400_RS21650	COG1596	polysaccharide export
KM400_RS21655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM400_RS21660	COG2226	methyltransferase
KM400_RS21665	COG0799	negative regulation of ribosome biogenesis
KM400_RS21670	COG1713	HD superfamily hydrolase involved in NAD metabolism
KM400_RS21680	COG1534	Rna-binding protein
KM400_RS21690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KM400_RS21695	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KM400_RS21720	COG1595	DNA-templated transcription, initiation
KM400_RS21730	COG0778	Nitroreductase
KM400_RS21735	COG2357	RelA SpoT domain protein
KM400_RS21745	COG1785	Belongs to the alkaline phosphatase family
KM400_RS21755	COG2267	carboxylic ester hydrolase activity
KM400_RS21790	COG1404	Belongs to the peptidase S8 family
KM400_RS21795	COG3186	Phenylalanine-4-hydroxylase
KM400_RS21805	COG2514	catechol 2,3-dioxygenase activity
KM400_RS21810	COG2259	Doxx family
KM400_RS21850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM400_RS21860	COG1012	belongs to the aldehyde dehydrogenase family
KM400_RS21860	COG1454	alcohol dehydrogenase
KM400_RS21865	COG0626	cystathionine gamma-synthase activity
KM400_RS21870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM400_RS21895	COG0768	penicillin binding
KM400_RS21910	COG0826	peptidase U32
KM400_RS21915	COG0826	peptidase U32
KM400_RS21920	COG4122	O-methyltransferase activity
KM400_RS21925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KM400_RS21945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM400_RS21955	COG0628	permease
KM400_RS21975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM400_RS21985	COG0482	sulfurtransferase activity
KM400_RS21990	COG1104	cysteine desulfurase activity
KM400_RS21995	COG1959	2 iron, 2 sulfur cluster binding
KM400_RS22000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KM400_RS22010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KM400_RS22035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM400_RS22045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KM400_RS22045	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KM400_RS22050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM400_RS22055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM400_RS22055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM400_RS22065	COG2244	polysaccharide biosynthetic process
KM400_RS22070	COG2323	membrane
KM400_RS22080	COG1862	Preprotein translocase
KM400_RS22110	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KM400_RS22120	COG0697	spore germination
KM400_RS22125	COG0697	spore germination
KM400_RS22130	COG0640	Transcriptional regulator
KM400_RS22155	COG0157	Belongs to the NadC ModD family
KM400_RS22160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KM400_RS22165	COG1104	cysteine desulfurase activity
KM400_RS22170	COG1827	regulation of RNA biosynthetic process
KM400_RS22175	COG2258	MOSC domain
KM400_RS22180	COG0077	Prephenate dehydratase
KM400_RS22185	COG0577	efflux transmembrane transporter activity
KM400_RS22190	COG0577	efflux transmembrane transporter activity
KM400_RS22195	COG1136	(ABC) transporter
KM400_RS22205	COG0745	RESPONSE REGULATOR receiver
KM400_RS22210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KM400_RS22215	COG3290	protein histidine kinase activity
KM400_RS22225	COG2868	ribosomal protein
KM400_RS22235	COG1530	ribonuclease E activity
KM400_RS22240	COG1994	Peptidase M50
KM400_RS22245	COG0739	heme binding
KM400_RS22250	COG2894	cell division
KM400_RS22270	COG1077	Cell shape determining protein MreB Mrl
KM400_RS22290	COG0285	dihydrofolate synthase activity
KM400_RS22295	COG0525	valine-tRNA ligase activity
KM400_RS22305	COG1388	LysM domain
KM400_RS22315	COG0113	porphobilinogen synthase activity
KM400_RS22320	COG1587	Uroporphyrinogen-III synthase
KM400_RS22330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM400_RS22340	COG1846	Transcriptional regulator
KM400_RS22345	COG1764	response to oxidative stress
KM400_RS22360	COG0470	DNA polymerase III
KM400_RS22360	COG1067	ATP-dependent peptidase activity
KM400_RS22405	COG0622	Phosphoesterase
KM400_RS22420	COG5401	PFAM Sporulation and spore germination
KM400_RS22440	COG1309	transcriptional regulator
KM400_RS22455	COG2197	response regulator
KM400_RS22460	COG2233	PERMEase
KM400_RS22470	COG0402	S-adenosylhomocysteine deaminase activity
KM400_RS22475	COG0402	S-adenosylhomocysteine deaminase activity
KM400_RS22485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM400_RS22495	COG0444	Belongs to the ABC transporter superfamily
KM400_RS22500	COG4608	Belongs to the ABC transporter superfamily
KM400_RS22505	COG3275	phosphorelay sensor kinase activity
KM400_RS22510	COG3279	Response regulator of the LytR AlgR family
KM400_RS22525	COG1983	PspC domain protein
KM400_RS22530	COG1396	sequence-specific DNA binding
KM400_RS22535	COG0697	spore germination
KM400_RS22545	COG1959	2 iron, 2 sulfur cluster binding
KM400_RS22550	COG1668	transmembrane transport
KM400_RS22555	COG4152	abc transporter atp-binding protein
KM400_RS22560	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KM400_RS22570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM400_RS22575	COG1876	peptidase activity
KM400_RS22580	COG0824	Thioesterase
KM400_RS22585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KM400_RS22590	COG1053	succinate dehydrogenase
KM400_RS22595	COG2009	succinate dehydrogenase
KM400_RS22600	COG1719	4-vinyl reductase, 4VR
KM400_RS22610	COG3118	belongs to the thioredoxin family
KM400_RS22615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KM400_RS22620	COG2086	electron transfer activity
KM400_RS22625	COG1024	Enoyl-CoA hydratase
KM400_RS22630	COG1309	transcriptional regulator
KM400_RS22635	COG0318	PFAM AMP-dependent synthetase and ligase
KM400_RS22655	COG2318	DinB family
KM400_RS22685	COG1131	(ABC) transporter
KM400_RS22690	COG2205	protein histidine kinase activity
KM400_RS22695	COG0745	RESPONSE REGULATOR receiver
KM400_RS22705	COG4895	conserved protein (DUF2196)
KM400_RS22710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KM400_RS22725	COG4509	Sortase family
KM400_RS22730	COG1120	ATPase activity
KM400_RS22745	COG5386	Cell surface protein
KM400_RS22755	COG5386	Cell surface protein
KM400_RS22760	COG1114	Component of the transport system for branched-chain amino acids
KM400_RS22765	COG1187	pseudouridine synthase activity
KM400_RS22775	COG1796	DNA polymerase
KM400_RS22775	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM400_RS22780	COG1286	toxin biosynthetic process
KM400_RS22825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM400_RS22835	COG1418	mRNA catabolic process
KM400_RS22860	COG2814	Major facilitator Superfamily
KM400_RS22865	COG1566	PFAM secretion protein HlyD family protein
KM400_RS22870	COG1309	transcriptional regulator
KM400_RS22875	COG1363	Peptidase, m42
KM400_RS22900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM400_RS22910	COG1484	DNA-dependent DNA replication
KM400_RS22915	COG3611	Membrane attachment protein
KM400_RS22925	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM400_RS22930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM400_RS22935	COG0237	dephospho-CoA kinase activity
KM400_RS22940	COG1971	Probably functions as a manganese efflux pump
KM400_RS22950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM400_RS22950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM400_RS22955	COG5002	protein histidine kinase activity
KM400_RS22960	COG0745	RESPONSE REGULATOR receiver
KM400_RS22980	COG0538	isocitrate dehydrogenase activity
KM400_RS22985	COG0372	Belongs to the citrate synthase family
KM400_RS22995	COG0628	permease
KM400_RS23000	COG3030	protein affecting phage T7 exclusion by the F plasmid
KM400_RS23025	COG1725	Transcriptional regulator
KM400_RS23030	COG0281	malic enzyme
KM400_RS23035	COG0587	DNA-directed DNA polymerase activity
KM400_RS23050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KM400_RS23070	COG4109	DRTGG domain
KM400_RS23085	COG0006	proline dipeptidase activity
KM400_RS23125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM400_RS23130	COG0662	Cupin 2, conserved barrel domain protein
KM400_RS23140	COG1476	TRANSCRIPTIONal
KM400_RS23155	COG1028	Short-chain dehydrogenase reductase Sdr
KM400_RS23160	COG0589	response to stress
KM400_RS23200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM400_RS23220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KM400_RS23225	COG0827	DNA restriction-modification system
KM400_RS23230	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KM400_RS23235	COG3874	Sporulation protein YtfJ
KM400_RS23250	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KM400_RS23260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM400_RS23275	COG1104	cysteine desulfurase activity
KM400_RS23285	COG0583	DNA-binding transcription factor activity
KM400_RS23290	COG0697	spore germination
KM400_RS23300	COG1956	GAF domain-containing protein
KM400_RS23305	COG0626	cystathionine gamma-synthase activity
KM400_RS23335	COG1595	DNA-templated transcription, initiation
KM400_RS23345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM400_RS23350	COG0454	-acetyltransferase
KM400_RS23355	COG0517	IMP dehydrogenase activity
KM400_RS23360	COG0123	including yeast histone deacetylase and acetoin utilization protein
KM400_RS23370	COG0745	RESPONSE REGULATOR receiver
KM400_RS23380	COG0666	response to abiotic stimulus
KM400_RS23415	COG1609	Transcriptional regulator
KM400_RS23420	COG4851	CamS sex pheromone cAM373 precursor
KM400_RS23425	COG3118	belongs to the thioredoxin family
KM400_RS23435	COG2309	aminopeptidase activity
KM400_RS23455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM400_RS23470	COG1674	ftsk spoiiie
KM400_RS23480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM400_RS23485	COG4848	Belongs to the UPF0354 family
KM400_RS23490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM400_RS23495	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KM400_RS23500	COG1363	Peptidase, m42
KM400_RS23510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM400_RS23525	COG0510	thiamine kinase activity
KM400_RS23530	COG1523	belongs to the glycosyl hydrolase 13 family
KM400_RS23540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM400_RS23545	COG1349	DNA-binding transcription factor activity
KM400_RS23550	COG1187	pseudouridine synthase activity
KM400_RS23555	COG2244	polysaccharide biosynthetic process
KM400_RS23560	COG2081	HI0933 family
KM400_RS23565	COG2814	Major facilitator Superfamily
KM400_RS23575	COG3832	glyoxalase III activity
KM400_RS23605	COG4975	Glucose uptake
KM400_RS23620	COG0314	molybdopterin synthase activity
KM400_RS23625	COG1763	Mo-molybdopterin cofactor biosynthetic process
KM400_RS23630	COG0303	'Molybdopterin
KM400_RS23640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM400_RS23645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM400_RS23670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM400_RS23680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM400_RS23725	COG2814	Major facilitator Superfamily
KM400_RS23730	COG0475	glutathione-regulated potassium exporter activity
KM400_RS23735	COG0490	domain, Protein
KM400_RS23740	COG0582	viral genome integration into host DNA
KM400_RS23750	COG1136	(ABC) transporter
KM400_RS23770	COG1242	4 iron, 4 sulfur cluster binding
KM400_RS23775	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KM400_RS23780	COG1131	(ABC) transporter
KM400_RS23790	COG1794	racemase activity, acting on amino acids and derivatives
KM400_RS23810	COG2267	carboxylic ester hydrolase activity
KM400_RS23815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM400_RS23820	COG0671	phosphoesterase, PA-phosphatase related
KM400_RS23825	COG0438	transferase activity, transferring glycosyl groups
KM400_RS23835	COG0521	Mo-molybdopterin cofactor biosynthetic process
KM400_RS23890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM400_RS23895	COG5002	protein histidine kinase activity
KM400_RS23900	COG4191	Histidine kinase
KM400_RS23905	COG2267	carboxylic ester hydrolase activity
KM400_RS23925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM400_RS23930	COG1116	anion transmembrane transporter activity
KM400_RS23935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM400_RS23960	COG0494	nUDIX hydrolase
KM400_RS23995	COG0288	reversible hydration of carbon dioxide
KM400_RS24000	COG1271	oxidase subunit
KM400_RS24005	COG1294	oxidase, subunit
KM400_RS24025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM400_RS24050	COG1842	Phage shock protein A
KM400_RS24080	COG5002	protein histidine kinase activity
KM400_RS24085	COG0745	RESPONSE REGULATOR receiver
KM400_RS24110	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM400_RS24115	COG1597	lipid kinase activity
KM400_RS24150	COG0586	Pfam SNARE associated Golgi protein
KM400_RS24160	COG0577	efflux transmembrane transporter activity
KM400_RS24165	COG1136	(ABC) transporter
KM400_RS24170	COG2207	Transcriptional regulator
KM400_RS24170	COG3708	Transcriptional regulator
KM400_RS24175	COG0745	RESPONSE REGULATOR receiver
KM400_RS24180	COG2205	protein histidine kinase activity
KM400_RS24185	COG0577	efflux transmembrane transporter activity
KM400_RS24190	COG0577	efflux transmembrane transporter activity
KM400_RS24195	COG1136	(ABC) transporter
KM400_RS24215	COG2188	Transcriptional regulator
KM400_RS24235	COG3964	amidohydrolase
KM400_RS24265	COG4948	Mandelate Racemase Muconate Lactonizing
KM400_RS24275	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KM400_RS24280	COG0596	Alpha beta hydrolase
KM400_RS24285	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KM400_RS24290	COG1169	isochorismate synthase
KM400_RS24295	COG1575	Belongs to the MenA family. Type 1 subfamily
KM400_RS24300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KM400_RS24320	COG0058	SHG alpha-glucan phosphorylase activity
KM400_RS24325	COG0297	glycogen (starch) synthase activity
KM400_RS24330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KM400_RS24445	COG0544	peptidyl-prolyl cis-trans isomerase activity
KM400_RS24480	COG1285	pathogenesis
KM400_RS24485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM400_RS24495	COG0166	Belongs to the GPI family
KM400_RS24500	COG2155	Conserved Protein
KM400_RS24505	COG1098	S1 RNA binding domain
KM400_RS24510	COG0436	Aminotransferase
KM400_RS24515	COG1522	sequence-specific DNA binding
KM400_RS24520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM400_RS24525	COG2267	carboxylic ester hydrolase activity
KM400_RS24535	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KM400_RS24555	COG5018	Exonuclease
KM400_RS24560	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM400_RS24580	COG2050	protein possibly involved in aromatic compounds catabolism
KM400_RS24590	COG1268	BioY protein
KM400_RS24600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM400_RS24605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KM400_RS24620	COG3584	3D domain protein
KM400_RS24635	COG1252	NADH dehydrogenase
KM400_RS24650	COG3708	Transcriptional regulator
KM400_RS24665	COG1683	Conserved Protein
KM400_RS24685	COG0316	Belongs to the HesB IscA family
KM400_RS24700	COG1252	NADH dehydrogenase
KM400_RS24710	COG2274	protein secretion by the type I secretion system
KM400_RS24715	COG0390	transport system, permease component
KM400_RS24720	COG2824	Alkylphosphonate utilization operon protein PhnA
KM400_RS24760	COG4837	Protein of unknown function (DUF1462)
KM400_RS24765	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KM400_RS24775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM400_RS24780	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KM400_RS24790	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM400_RS24795	COG0647	UMP catabolic process
KM400_RS24805	COG2445	Protein of unknown function DUF86
KM400_RS24810	COG1494	fructose-1,6-bisphosphatase
KM400_RS24825	COG4470	Protein conserved in bacteria
KM400_RS24835	COG0789	Transcriptional regulator
KM400_RS24840	COG4377	Putative membrane peptidase family (DUF2324)
KM400_RS24865	COG0739	heme binding
KM400_RS24875	COG3377	Domain of unknown function (DUF1805)
KM400_RS24880	COG0737	Belongs to the 5'-nucleotidase family
KM400_RS24885	COG1695	Transcriptional regulator
KM400_RS24895	COG0719	Fe-S assembly protein
KM400_RS24900	COG0822	iron-sulfur transferase activity
KM400_RS24905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KM400_RS24910	COG0719	Fe-S assembly protein
KM400_RS24915	COG0396	ATPase activity
KM400_RS24920	COG1464	Belongs to the NlpA lipoprotein family
KM400_RS24925	COG1464	Belongs to the NlpA lipoprotein family
KM400_RS24930	COG2011	ABC-type metal ion transport system permease component
KM400_RS24935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM400_RS24945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM400_RS24950	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM400_RS24960	COG1393	Belongs to the ArsC family
KM400_RS25005	COG0039	L-malate dehydrogenase activity
KM400_RS25030	COG1309	transcriptional regulator
KM400_RS25035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM400_RS25040	COG1960	acyl-CoA dehydrogenase activity
KM400_RS25045	COG0183	Belongs to the thiolase family
KM400_RS25050	COG1024	Enoyl-CoA hydratase
KM400_RS25050	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM400_RS25060	COG1686	Belongs to the peptidase S11 family
KM400_RS25075	COG0011	TIGRFAM Protein of
KM400_RS25080	COG0840	transmembrane signaling receptor activity
KM400_RS25100	COG2814	Major facilitator Superfamily
KM400_RS25105	COG0531	amino acid
KM400_RS25115	COG0706	membrane insertase activity
KM400_RS25125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM400_RS25160	COG0586	Pfam SNARE associated Golgi protein
KM400_RS25170	COG1376	ErfK ybiS ycfS ynhG family protein
KM400_RS25175	COG0745	RESPONSE REGULATOR receiver
KM400_RS25180	COG5002	protein histidine kinase activity
KM400_RS25205	COG2151	metal-sulfur cluster biosynthetic enzyme
KM400_RS25210	COG3227	Zinc metalloprotease (Elastase)
KM400_RS25215	COG1741	Belongs to the pirin family
KM400_RS25230	COG0475	glutathione-regulated potassium exporter activity
KM400_RS25235	COG0490	domain, Protein
KM400_RS25240	COG1115	amino acid carrier protein
KM400_RS25245	COG0783	Belongs to the Dps family
KM400_RS25260	COG1611	Belongs to the LOG family
KM400_RS25280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM400_RS25285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM400_RS25290	COG1115	amino acid carrier protein
KM400_RS25295	COG1115	amino acid carrier protein
KM400_RS25300	COG2910	NAD(P)H-binding
KM400_RS25315	COG0656	L-ascorbic acid biosynthetic process
KM400_RS25320	COG2814	Major facilitator Superfamily
KM400_RS25325	COG1733	regulation of RNA biosynthetic process
KM400_RS25335	COG1252	NADH dehydrogenase
KM400_RS25340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KM400_RS25345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM400_RS25355	COG3290	protein histidine kinase activity
KM400_RS25355	COG0840	transmembrane signaling receptor activity
KM400_RS25365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM400_RS25370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM400_RS25385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM400_RS25440	COG0557	exoribonuclease II activity
KM400_RS25445	COG1647	Serine aminopeptidase, S33
KM400_RS25450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM400_RS25455	COG1346	cytolysis
KM400_RS25555	COG4695	Portal protein
KM400_RS25575	COG4974	Belongs to the 'phage' integrase family
KM400_RS25590	COG0149	triose-phosphate isomerase activity
KM400_RS25600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM400_RS25615	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KM400_RS25640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM400_RS25655	COG2323	membrane
KM400_RS25660	COG0740	serine-type endopeptidase activity
KM400_RS25665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM400_RS25675	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KM400_RS25685	COG1051	belongs to the nudix hydrolase family
KM400_RS25695	COG0492	ferredoxin-NADP+ reductase activity
KM400_RS25700	COG0457	Tetratricopeptide repeat
KM400_RS25705	COG0110	maltose O-acetyltransferase activity
KM400_RS25725	COG1950	PFAM Membrane protein of
KM400_RS25735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM400_RS25740	COG0556	nucleotide-excision repair
KM400_RS25760	COG0789	Transcriptional regulator
KM400_RS25785	COG2855	membrane
KM400_RS25790	COG0583	DNA-binding transcription factor activity
KM400_RS25800	COG0655	NAD(P)H dehydrogenase (quinone) activity
KM400_RS25805	COG0488	(ABC) transporter
KM400_RS25815	COG1132	(ABC) transporter
KM400_RS25820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM400_RS25825	COG3409	Peptidoglycan-binding domain 1 protein
KM400_RS25825	COG0793	Belongs to the peptidase S41A family
KM400_RS25830	COG2177	Part of the ABC transporter FtsEX involved in
KM400_RS25835	COG2884	Cell division ATP-binding protein ftsE
KM400_RS25850	COG0653	protein targeting
KM400_RS25855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KM400_RS25860	COG1278	Cold shock
KM400_RS25865	COG1040	competence protein
KM400_RS25870	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KM400_RS25875	COG1388	LysM domain
KM400_RS25875	COG0791	NLP P60 protein
KM400_RS25880	COG1733	regulation of RNA biosynthetic process
KM400_RS25885	COG1307	EDD domain protein, DegV family
KM400_RS25890	COG1739	Uncharacterized protein family UPF0029
KM400_RS25895	COG1316	TRANSCRIPTIONal
KM400_RS25900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM400_RS25905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM400_RS25910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KM400_RS25920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KM400_RS25920	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KM400_RS25935	COG3394	polysaccharide catabolic process
KM400_RS25940	COG1486	melibiose metabolic process
KM400_RS25945	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM400_RS25950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM400_RS25960	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KM400_RS25965	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM400_RS25970	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM400_RS25980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM400_RS25985	COG1301	dicarboxylic acid transport
KM400_RS25995	COG0346	lactoylglutathione lyase activity
KM400_RS26000	COG1511	domain protein
KM400_RS26005	COG0583	DNA-binding transcription factor activity
KM400_RS26010	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KM400_RS26025	COG1271	oxidase subunit
KM400_RS26030	COG1294	oxidase, subunit
KM400_RS26035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM400_RS26045	COG1620	l-lactate permease
KM400_RS26055	COG2389	metal-binding protein
KM400_RS26065	COG1368	sulfuric ester hydrolase activity
KM400_RS26080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM400_RS26090	COG1215	transferase activity, transferring glycosyl groups
KM400_RS26095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM400_RS26100	COG3584	3D domain protein
KM400_RS26100	COG1388	LysM domain
KM400_RS26125	COG4715	Zinc finger, swim domain protein
KM400_RS26130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM400_RS26170	COG0577	efflux transmembrane transporter activity
KM400_RS26175	COG1136	(ABC) transporter
KM400_RS26210	COG5002	protein histidine kinase activity
KM400_RS26215	COG0745	RESPONSE REGULATOR receiver
KM400_RS26220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM400_RS26240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM400_RS26245	COG1134	teichoic acid transport
KM400_RS26250	COG1682	transport, permease protein
KM400_RS26255	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KM400_RS26295	COG1609	Transcriptional regulator
KM400_RS26310	COG0739	heme binding
KM400_RS26330	COG2385	sporulation resulting in formation of a cellular spore
KM400_RS26345	COG4836	Membrane
KM400_RS26350	COG1007	ATP synthesis coupled electron transport
KM400_RS26355	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM400_RS26360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM400_RS26370	COG0839	Belongs to the complex I subunit 6 family
KM400_RS26385	COG0649	NAD binding
KM400_RS26390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM400_RS26405	COG3300	MHYT domain
KM400_RS26405	COG5001	Diguanylate cyclase
KM400_RS26455	COG0356	it plays a direct role in the translocation of protons across the membrane
KM400_RS26490	COG0698	ribose 5-phosphate isomerase
KM400_RS26500	COG2190	(PTS) system
KM400_RS26505	COG2259	Doxx family
KM400_RS26510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KM400_RS26525	COG0009	L-threonylcarbamoyladenylate synthase
KM400_RS26540	COG2890	protein-(glutamine-N5) methyltransferase activity
KM400_RS26560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KM400_RS26565	COG1494	fructose-1,6-bisphosphatase
KM400_RS26585	COG4821	SIS domain
KM400_RS26595	COG3343	RNA polymerase activity
KM400_RS26605	COG1960	acyl-CoA dehydrogenase activity
KM400_RS26610	COG1960	acyl-CoA dehydrogenase activity
KM400_RS26615	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM400_RS26620	COG0183	Belongs to the thiolase family
KM400_RS26625	COG0247	lactate metabolic process
KM400_RS26625	COG2181	nitrate reductase activity
KM400_RS26630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM400_RS26640	COG5001	Diguanylate cyclase
KM400_RS26640	COG3300	MHYT domain
KM400_RS26660	COG2197	response regulator
KM400_RS26665	COG4585	Histidine kinase
KM400_RS26670	COG0842	Transport permease protein
KM400_RS26675	COG1131	(ABC) transporter
KM400_RS26680	COG0024	Methionine aminopeptidase
KM400_RS26690	COG2234	aminopeptidase activity
KM400_RS26710	COG1595	DNA-templated transcription, initiation
KM400_RS26715	COG0018	arginyl-trna synthetase
KM400_RS26720	COG4506	Protein conserved in bacteria
KM400_RS26725	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM400_RS26740	COG0010	Belongs to the arginase family
KM400_RS26750	COG2814	Major facilitator Superfamily
KM400_RS26755	COG0789	Transcriptional regulator
KM400_RS26760	COG0584	glycerophosphoryl diester phosphodiesterase
KM400_RS26765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM400_RS26775	COG1994	Peptidase M50
KM400_RS26785	COG1078	dGTPase activity
KM400_RS26790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM400_RS26795	COG1120	ATPase activity
KM400_RS26800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM400_RS26805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM400_RS26825	COG0095	Lipoate-protein ligase
KM400_RS26830	COG0280	phosphate acetyltransferase
KM400_RS26845	COG3773	Cell wall hydrolase
KM400_RS26855	COG2363	Small membrane protein
KM400_RS26865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM400_RS26870	COG2233	PERMEase
KM400_RS26875	COG0561	phosphatase activity
KM400_RS26880	COG2814	Major facilitator Superfamily
KM400_RS26890	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM400_RS26895	COG1131	(ABC) transporter
KM400_RS26900	COG2755	lipolytic protein G-D-S-L family
KM400_RS26905	COG1609	Transcriptional regulator
KM400_RS26915	COG0460	homoserine dehydrogenase
KM400_RS26925	COG2873	o-acetylhomoserine
KM400_RS26935	COG1011	Hydrolase
KM400_RS26940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM400_RS26950	COG2197	response regulator
KM400_RS26960	COG0351	phosphomethylpyrimidine kinase
KM400_RS26965	COG3706	GGDEF domain
KM400_RS26970	COG2879	small protein
KM400_RS26975	COG1966	Carbon starvation protein
KM400_RS26980	COG3279	Response regulator of the LytR AlgR family
KM400_RS26985	COG0477	Major facilitator Superfamily
KM400_RS27010	COG0840	transmembrane signaling receptor activity
KM400_RS27020	COG1607	acyl-coa hydrolase
KM400_RS27035	COG0488	(ABC) transporter
KM400_RS27055	COG0463	Glycosyl transferase, family 2
KM400_RS27060	COG1309	transcriptional regulator
KM400_RS27065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM400_RS27070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM400_RS27070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM400_RS27075	COG0628	permease
KM400_RS27090	COG3279	Response regulator of the LytR AlgR family
KM400_RS27095	COG3275	phosphorelay sensor kinase activity
KM400_RS27100	COG2814	Major facilitator Superfamily
KM400_RS27105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM400_RS27110	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KM400_RS27115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM400_RS27135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM400_RS27140	COG1272	protein, Hemolysin III
KM400_RS27165	COG1164	Oligoendopeptidase f
KM400_RS27185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM400_RS27190	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KM400_RS27195	COG4853	Protein conserved in bacteria
KM400_RS27200	COG4863	YycH protein
KM400_RS27205	COG5002	protein histidine kinase activity
KM400_RS27210	COG0745	RESPONSE REGULATOR receiver
KM400_RS27240	COG0305	Participates in initiation and elongation during chromosome replication
KM400_RS27250	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KM400_RS27255	COG4241	membrane
KM400_RS27265	COG0629	single-stranded DNA binding
KM400_RS27275	COG0012	GTP binding
KM400_RS27280	COG4481	Protein conserved in bacteria
KM400_RS27285	COG0668	transmembrane transport
KM400_RS27295	COG1475	DNA binding
KM400_RS27300	COG1192	Involved in chromosome partitioning
KM400_RS27325	COG1847	R3H domain protein
KM400_RS27330	COG0706	membrane insertase activity
KM400_RS27340	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KM400_RS27395	COG3344	reverse transcriptase
KM400_RS27475	COG3344	reverse transcriptase
KM400_RS27670	COG4962	Type ii secretion system protein e
KM400_RS27810	COG2311	Membrane
KM400_RS27835	COG4196	transglutaminase domain protein
KM400_RS27840	COG0671	phosphoesterase, PA-phosphatase related
KM400_RS27860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM400_RS27865	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM400_RS28040	COG2002	toxin-antitoxin pair type II binding
KM400_RS28050	COG4974	Belongs to the 'phage' integrase family
KM400_RS28110	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM400_RS28120	COG4974	Belongs to the 'phage' integrase family
KM400_RS28145	COG0457	Tetratricopeptide repeat
KM400_RS28470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM400_RS28480	COG4166	transmembrane transport
KM400_RS28525	COG1280	lysine exporter protein (LysE YggA)
KM400_RS28555	COG0681	Belongs to the peptidase S26 family
KM400_RS28630	COG1309	transcriptional regulator
KM400_RS28635	COG1683	Conserved Protein
KM400_RS28685	COG1192	Involved in chromosome partitioning