locus-tag class description BABF1_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BABF1_RS00015 ENOG410848D S4 domain protein YaaA BABF1_RS00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BABF1_RS00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BABF1_RS00100 ENOG4105ZMH deoxynucleoside kinase BABF1_RS00110 ENOG4105GTG Isochorismatase BABF1_RS00115 ENOG4108Z6B deaminase BABF1_RS00125 ENOG4105C6E dna polymerase iii BABF1_RS00145 ENOG41067KS pro-sigma K processing BABF1_RS00180 ENOG4105CXN decarboxylase BABF1_RS00190 ENOG4105FA2 dna polymerase iii BABF1_RS00195 ENOG4105MA4 psp1 domain protein BABF1_RS00205 ENOG41060K3 Methyltransferase BABF1_RS00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BABF1_RS00220 ENOG4105KRN Transcriptional regulator, abrb family BABF1_RS00230 ENOG4105F8V Hydrolase, tatD family BABF1_RS00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BABF1_RS00245 ENOG4105XFA sporulation peptidase YabG BABF1_RS00250 ENOG4105W42 Veg protein BABF1_RS00265 ENOG4105DFT pur operon repressor BABF1_RS00270 ENOG4105KME endoribonuclease L-psp BABF1_RS00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BABF1_RS00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BABF1_RS00300 ENOG4108JA2 transcriptioN-repair coupling factor BABF1_RS00305 ENOG4108M14 stage v sporulation protein t BABF1_RS00315 ENOG4108IY2 MazG family BABF1_RS00320 ENOG41082I2 s4 domain protein BABF1_RS00325 ENOG4105VYY sporulation protein yabp BABF1_RS00340 ENOG41060GV RNA binding s1 domain protein BABF1_RS00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BABF1_RS00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase BABF1_RS00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BABF1_RS00385 ENOG4105C6T cysteine synthase BABF1_RS00390 ENOG4105CRQ synthase (Component I) BABF1_RS00395 ENOG4105DDQ anthranilate synthase BABF1_RS00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BABF1_RS00405 ENOG4105EEI dihydropteroate synthase BABF1_RS00410 ENOG4105KRF dihydroneopterin aldolase BABF1_RS00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BABF1_RS00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BABF1_RS00455 ENOG4108Z0C Uvrb UvrC protein BABF1_RS00470 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BABF1_RS00480 ENOG4105CTP PilT protein domain protein BABF1_RS00500 ENOG4105D7W serine acetyltransferase BABF1_RS00515 ENOG4105C2N RNA methyltransferase TrmH family group 3 BABF1_RS00520 ENOG4105M0M Tetracycline resistance protein BABF1_RS00525 ENOG4105QIV RNA polymerase BABF1_RS00540 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BABF1_RS00565 ENOG4107Y49 methyltransferase BABF1_RS00575 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BABF1_RS00580 ENOG4105XPM ribosomal protein BABF1_RS00685 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BABF1_RS00710 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BABF1_RS00720 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BABF1_RS00730 ENOG41067V7 50S ribosomal protein L36 BABF1_RS00760 ENOG4108JJB ABC transporter BABF1_RS00765 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BABF1_RS00770 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BABF1_RS00795 ENOG4105D1F ATP-binding protein BABF1_RS00810 ENOG4108NMV polysaccharide deacetylase BABF1_RS00890 ENOG4105C8B TIGR00159 family BABF1_RS00895 ENOG4107U5W ybbr family BABF1_RS00910 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BABF1_RS00915 ENOG4108VQT Alpha beta hydrolase fold protein BABF1_RS00925 ENOG4105CMG Carbohydrate kinase BABF1_RS00935 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BABF1_RS00940 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BABF1_RS00975 ENOG4108UMI ABC transporter, permease BABF1_RS00980 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BABF1_RS00985 ENOG4105D01 (LipO)protein BABF1_RS00990 ENOG4105EE1 crotonyl-CoA reductase BABF1_RS01015 ENOG4105C2C drug resistance transporter, Bcr CflA BABF1_RS01030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BABF1_RS01035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BABF1_RS01040 ENOG4105C3U ABC transporter BABF1_RS01045 ENOG4108JQ7 (ABC) transporter BABF1_RS01075 ENOG4108J59 Extracellular solute-binding protein, family 5 BABF1_RS01080 ENOG4108J59 Extracellular solute-binding protein, family 5 BABF1_RS01090 ENOG4105II7 pyrroline-5-carboxylate reductase BABF1_RS01095 ENOG4107XDY Nicotinamide Mononucleotide Transporter BABF1_RS01105 ENOG4105E0C molybdate abc transporter BABF1_RS01110 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BABF1_RS01115 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BABF1_RS01125 ENOG4105EGI Transcriptional regulator BABF1_RS01145 ENOG4105F6E Acyl-transferase BABF1_RS01165 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BABF1_RS01175 ENOG4108RE7 deoxyribonuclease BABF1_RS01180 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BABF1_RS01205 ENOG4105C5H ABC transporter BABF1_RS01220 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BABF1_RS01230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BABF1_RS01235 ENOG4105C3U ABC transporter BABF1_RS01240 ENOG4108JQ7 (ABC) transporter BABF1_RS01270 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BABF1_RS01275 ENOG4105ERH Fumarylacetoacetate hydrolase BABF1_RS01285 ENOG4108SC4 )-transporter BABF1_RS01295 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BABF1_RS01310 ENOG4107ZXI Rhomboid family BABF1_RS01320 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BABF1_RS01325 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BABF1_RS01335 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BABF1_RS01435 ENOG4105K8N protein family UPF0079, ATPase BABF1_RS01440 ENOG41072GX Peptidase M22 Glycoprotease BABF1_RS01445 ENOG410801F ribosomal-protein-alanine acetyltransferase BABF1_RS01450 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BABF1_RS01455 ENOG4105C5H ABC transporter BABF1_RS01470 ENOG4108TYN CAAX amino terminal protease family protein BABF1_RS01490 ENOG4105C7N Xanthine uracil vitamin C permease BABF1_RS01500 ENOG4105BZU Histidine kinase BABF1_RS01520 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BABF1_RS01540 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BABF1_RS01560 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BABF1_RS01565 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BABF1_RS01570 ENOG4105C83 adenylosuccinate lyase BABF1_RS01580 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BABF1_RS01605 ENOG4108V3E phosphoribosylglycinamide formyltransferase BABF1_RS01615 ENOG4105C12 Phosphoribosylglycinamide synthetase BABF1_RS01640 ENOG4105C4R Atp-dependent dna helicase BABF1_RS01665 ENOG4108W2Y isochorismatase BABF1_RS01670 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BABF1_RS01675 ENOG4108UMI ABC transporter, permease BABF1_RS01680 ENOG4105D01 (LipO)protein BABF1_RS01700 ENOG410834F Transcriptional regulator BABF1_RS01725 ENOG4105CBD Diacylglycerol kinase BABF1_RS01730 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BABF1_RS01735 ENOG4108JPW Aminotransferase BABF1_RS01745 ENOG4105C26 Dehydrogenase BABF1_RS01750 ENOG4105KPY Small multidrug resistance protein BABF1_RS01770 ENOG4105D9N nucleoside BABF1_RS01775 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BABF1_RS01790 ENOG4108W15 Protein of unknown function (DUF1456) BABF1_RS01805 ENOG4105DTQ mandelate racemase muconate lactonizing BABF1_RS01815 ENOG4105DFD Na H antiporter BABF1_RS01835 ENOG4105D3R alkyl hydroperoxide reductase BABF1_RS01840 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BABF1_RS01850 ENOG4107W7X Aldolase BABF1_RS01855 ENOG4105EHG Permease protein BABF1_RS01860 ENOG4105DQ5 transport system permease protein BABF1_RS01865 ENOG4108V5C ABC transporter BABF1_RS01885 ENOG4106UIA BABF1_RS01890 ENOG4106UIA BABF1_RS01915 ENOG4105BZU Histidine kinase BABF1_RS01935 ENOG410756H nucleotidyltransferase BABF1_RS01940 ENOG4105D2S major facilitator superfamily BABF1_RS01955 ENOG4105E5Q amino acid AbC transporter BABF1_RS01960 ENOG4105EAB amino acid AbC transporter BABF1_RS01970 ENOG4105C8Q Methyl-accepting chemotaxis BABF1_RS01975 ENOG4105C8Q Methyl-accepting chemotaxis BABF1_RS01985 ENOG4105CI1 PTS System BABF1_RS02015 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BABF1_RS02030 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BABF1_RS02045 ENOG4105C5H ABC transporter BABF1_RS02070 ENOG41062JF Transcriptional regulator BABF1_RS02090 ENOG4105DEU major facilitator superfamily BABF1_RS02105 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BABF1_RS02120 ENOG4108N0M stress protein BABF1_RS02125 ENOG4106FN3 tellurium resistance protein BABF1_RS02130 ENOG4106FN3 tellurium resistance protein BABF1_RS02135 ENOG4107TS3 membrane protein, TerC BABF1_RS02140 ENOG4108TTB tellurium resistance protein BABF1_RS02160 ENOG4105KJF protein tyrosine phosphatase BABF1_RS02170 ENOG4107U9T Pfam:Ribonuclease_BN BABF1_RS02175 ENOG4105C59 p-type ATPase BABF1_RS02180 ENOG4108IPJ Membrane BABF1_RS02200 ENOG4107ZTW SNARE associated Golgi BABF1_RS02215 ENOG410606W general stress protein BABF1_RS02220 ENOG4105UPD Calcium Proton BABF1_RS02260 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BABF1_RS02265 ENOG4105VTR Integrase BABF1_RS02270 ENOG4108IMY Transcriptional regulator BABF1_RS02530 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BABF1_RS02540 ENOG4108JUB Transcriptional regulator BABF1_RS02550 ENOG4108IQI permease BABF1_RS02575 ENOG4105CSV Glutaminase BABF1_RS02585 ENOG4108A04 Beta-lactamase BABF1_RS02600 ENOG4105CKK Glycosyl transferase, family 2 BABF1_RS02610 ENOG4107QQG Dehydrogenase BABF1_RS02615 ENOG4105C3I Nad-dependent epimerase dehydratase BABF1_RS02635 ENOG4105F1A Pyruvate formate-lyase BABF1_RS02655 ENOG4105CI2 imidazolone-5-propionate hydrolase BABF1_RS02660 ENOG4105ECP epimerase BABF1_RS02690 ENOG41067AE Membrane-bound metal-dependent hydrolase BABF1_RS02695 ENOG4105CEN a g-specific adenine glycosylase BABF1_RS02700 ENOG4106BXE BABF1_RS02720 ENOG4105BZ1 (ABC) transporter BABF1_RS02725 ENOG4107NBY Membrane BABF1_RS02730 ENOG4105CBC glutamate synthase BABF1_RS02740 ENOG4108IUW ABC transporter BABF1_RS02760 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BABF1_RS02765 ENOG4105G5W regulator Fur family BABF1_RS02880 ENOG4108JQC penicillin-binding protein 1A BABF1_RS02885 ENOG4107ZQN disulfide bond BABF1_RS02895 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BABF1_RS02905 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BABF1_RS02910 ENOG4105BZU Histidine kinase BABF1_RS02915 ENOG4105CYN Serine protein kinase BABF1_RS02935 ENOG4105C94 Transporter BABF1_RS02950 ENOG4105DZ6 Band 7 protein BABF1_RS02960 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BABF1_RS02965 ENOG4108MRH transcriptional regulatory protein BABF1_RS02970 ENOG4105D4T Citrate transporter BABF1_RS02990 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BABF1_RS02995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BABF1_RS03000 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BABF1_RS03005 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BABF1_RS03010 ENOG4105BZ7 extracellular solute-binding protein family 1 BABF1_RS03015 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BABF1_RS03020 ENOG4108STX response regulator BABF1_RS03025 ENOG4105US7 Histidine kinase BABF1_RS03050 ENOG4108MRH transcriptional regulatory protein BABF1_RS03060 ENOG4105C6K Malic enzyme BABF1_RS03070 ENOG4108UZ3 Transporter BABF1_RS03075 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BABF1_RS03085 ENOG4105BZU Histidine kinase BABF1_RS03090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BABF1_RS03095 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BABF1_RS03100 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BABF1_RS03105 ENOG4108JB9 formate dehydrogenase BABF1_RS03125 ENOG4105CUB amino acid BABF1_RS03135 ENOG4105C59 p-type ATPase BABF1_RS03140 ENOG4105DAP Nicotinate phosphoribosyltransferase BABF1_RS03175 ENOG41073R8 VanW family BABF1_RS03180 ENOG4108KGH TRANSCRIPTIONal BABF1_RS03185 ENOG4105D9N nucleoside BABF1_RS03190 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BABF1_RS03195 ENOG4105C37 (CBS) domain BABF1_RS03200 ENOG4108IJ0 Aspartate ammonia-lyase BABF1_RS03205 ENOG4105DAA L-lactate BABF1_RS03220 ENOG4105DUX Transporter BABF1_RS03225 ENOG4108MES Periplasmic binding protein BABF1_RS03230 ENOG4105DQ5 transport system permease protein BABF1_RS03235 ENOG4108IHU transport system permease protein BABF1_RS03240 ENOG4105E0A ABC, transporter BABF1_RS03245 ENOG4105DMQ Methyltransferase BABF1_RS03255 ENOG4105EXW epimerase dehydratase BABF1_RS03265 ENOG4107T89 von Willebrand factor, type A BABF1_RS03270 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BABF1_RS03275 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BABF1_RS03290 ENOG4105BZU Histidine kinase BABF1_RS03295 ENOG4105D5Q Arginine ornithine antiporter BABF1_RS03300 ENOG4107414 GntR family transcriptional regulator BABF1_RS03305 ENOG4105C5Y PTS System BABF1_RS03310 ENOG4105CG3 alpha amylase, catalytic region BABF1_RS03325 ENOG4105E1K spore germination protein BABF1_RS03335 ENOG4105CRN Aminoglycoside phosphotransferase BABF1_RS03340 ENOG4105BZG amino acid carrier protein BABF1_RS03345 ENOG4105CDA abc transporter atp-binding protein BABF1_RS03350 ENOG4105CT1 (ABC) transporter BABF1_RS03355 ENOG4105EAD ABC transporter BABF1_RS03360 ENOG4105DRP amino acid AbC transporter BABF1_RS03365 ENOG4108IQI permease BABF1_RS03390 ENOG4105D29 Helix-turn-helix type 11 domain protein BABF1_RS03395 ENOG4105NAE bifunctional deaminase-reductase domain protein BABF1_RS03400 ENOG4105BZU Histidine kinase BABF1_RS03415 ENOG4105CHH sulfate transporter BABF1_RS03420 ENOG41068KF Universal stress protein BABF1_RS03430 ENOG4105DEF Extracellular solute-binding protein, family 5 BABF1_RS03440 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BABF1_RS03445 ENOG4108JQ7 (ABC) transporter BABF1_RS03455 ENOG4105CXY transporter BABF1_RS03460 ENOG41067TZ transcriptional regulator, MarR family BABF1_RS03470 ENOG4105ETE Transcriptional regulator (LacI family BABF1_RS03475 ENOG4108RVA ribokinase BABF1_RS03485 ENOG4105C2J ABC transporter BABF1_RS03490 ENOG4105CNN ABC, transporter BABF1_RS03495 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BABF1_RS03500 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BABF1_RS03560 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BABF1_RS03565 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BABF1_RS03570 ENOG41069ER domain protein BABF1_RS03575 ENOG4105VZ8 Transcriptional regulator BABF1_RS03580 ENOG4107D63 BABF1_RS03590 ENOG4105DUX Transporter BABF1_RS03610 ENOG4105C85 amino acid BABF1_RS03615 ENOG4105C7N Xanthine uracil vitamin C permease BABF1_RS03655 ENOG4105BZ9 Cytochrome C oxidase, subunit I BABF1_RS03660 ENOG4105E2S oxidase) subunit II BABF1_RS03665 ENOG4108IQI permease BABF1_RS03680 ENOG4106CAD Protein of unknown function (DUF3311) BABF1_RS03685 ENOG4105E1V na solute symporter BABF1_RS03700 ENOG4108NHD germination protein BABF1_RS03705 ENOG4105CE1 Ferrous iron transport protein b BABF1_RS03710 ENOG4105CE1 Ferrous iron transport protein b BABF1_RS03715 ENOG4105CE1 Ferrous iron transport protein b BABF1_RS03720 ENOG4105CVA phosphate BABF1_RS03725 ENOG4105C8U phosphate abc transporter BABF1_RS03730 ENOG4105E2Z phosphate ABC transporter (Permease BABF1_RS03860 ENOG41080XQ Signal transduction protein with cbs domains BABF1_RS03880 ENOG4105ETU transcriptional activator (TenA BABF1_RS03890 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BABF1_RS03900 ENOG4108VEU Thiamine monophosphate synthase BABF1_RS03905 ENOG41080HI glycine oxidase BABF1_RS03920 ENOG4105D06 uba thif-type nad fad binding protein BABF1_RS03925 ENOG4105DWF phosphomethylpyrimidine kinase BABF1_RS03975 ENOG4108INS Transcriptional regulator BABF1_RS03990 ENOG4105C7N Xanthine uracil vitamin C permease BABF1_RS04000 ENOG4108PXI ErfK YbiS YcfS YnhG BABF1_RS04020 ENOG4105C5Y PTS System BABF1_RS04075 ENOG4107Y03 Nitroreductase BABF1_RS04080 ENOG4105ED1 spovr family BABF1_RS04105 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BABF1_RS04110 ENOG4105XTG Pfam:DUF156 BABF1_RS04115 ENOG4105VFE sira family BABF1_RS04120 ENOG4107TPS domain protein BABF1_RS04125 ENOG4105VFE sira family BABF1_RS04130 ENOG41085GJ domain protein BABF1_RS04140 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BABF1_RS04145 ENOG41087NI Sulfite exporter TauE/SafE BABF1_RS04155 ENOG4108KGH TRANSCRIPTIONal BABF1_RS04180 ENOG4105EMD TRANSCRIPTIONal BABF1_RS04185 ENOG4105VCP PTS System BABF1_RS04190 ENOG4105VZJ PTS System BABF1_RS04210 ENOG41069ER domain protein BABF1_RS04215 ENOG4107RBB ABC transporter, permease BABF1_RS04220 ENOG4105C19 ABC transporter BABF1_RS04250 ENOG4105WEF catalase BABF1_RS04285 ENOG4107T5V SNARE associated Golgi BABF1_RS04315 ENOG4105CUB amino acid BABF1_RS04320 ENOG4107RWR Sodium hydrogen exchanger BABF1_RS04330 ENOG4106KNT transcriptional regulator BABF1_RS04365 ENOG4108PCN EamA-like transporter family BABF1_RS04370 ENOG4108YXU transcriptional regulator AsnC family BABF1_RS04380 ENOG4105KPY Small multidrug resistance protein BABF1_RS04385 ENOG4105KPY Small multidrug resistance protein BABF1_RS04410 ENOG4105NF4 modulator of drug activity BABF1_RS04415 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BABF1_RS04420 ENOG4105E5W Transporter BABF1_RS04430 ENOG4107RKG DJ-1/PfpI family BABF1_RS04435 ENOG4105CH6 catalase BABF1_RS04445 ENOG4105D5Q Arginine ornithine antiporter BABF1_RS04450 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BABF1_RS04460 ENOG4105C26 Dehydrogenase BABF1_RS04465 ENOG4105BZ1 (ABC) transporter BABF1_RS04480 ENOG4105DRP amino acid AbC transporter BABF1_RS04485 ENOG4105CDA abc transporter atp-binding protein BABF1_RS04500 ENOG410839P BABF1_RS04535 ENOG4107FQX Alpha-acetolactate decarboxylase BABF1_RS04565 ENOG4105D4P Coproporphyrinogen iii oxidase BABF1_RS04580 ENOG4105CHH sulfate transporter BABF1_RS04620 ENOG4106AKK s-layer domain-containing protein BABF1_RS04630 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BABF1_RS04635 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BABF1_RS04650 ENOG4105CGU Enoyl-CoA hydratase BABF1_RS04665 ENOG4105DER m42 family BABF1_RS04685 ENOG4105CTU Proline racemase BABF1_RS04725 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BABF1_RS04735 ENOG4108JQ7 (ABC) transporter BABF1_RS04740 ENOG4105PKS Excinuclease abc c subunit domain protein BABF1_RS04770 ENOG4105CSH Transporter BABF1_RS04780 ENOG4108MRH transcriptional regulatory protein BABF1_RS04830 ENOG4105CDU Replicative dna helicase BABF1_RS04860 ENOG4105C0R drug resistance transporter emrb qaca subfamily BABF1_RS04910 ENOG4108IG5 Transcriptional regulator BABF1_RS04930 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BABF1_RS04950 ENOG4105CMT Dihydroxyacetone kinase BABF1_RS04960 ENOG4105CMT Dihydroxyacetone kinase BABF1_RS04965 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BABF1_RS04970 ENOG410847I Transcriptional regulator, BadM Rrf2 family BABF1_RS05000 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BABF1_RS05065 ENOG4105WN5 stage II sporulation protein BABF1_RS05075 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BABF1_RS05085 ENOG4108MJI response regulator BABF1_RS05090 ENOG4105BZU Histidine kinase BABF1_RS05095 ENOG4105BZU Histidine kinase BABF1_RS05115 ENOG4105K8R UPF0145 protein BABF1_RS05145 ENOG4107VRP DNA repair exonuclease BABF1_RS05155 ENOG4105D7V transposase BABF1_RS05170 ENOG4108IND Tetr family transcriptional regulator BABF1_RS05175 ENOG4105EQ0 Major Facilitator superfamily BABF1_RS05195 ENOG4108MUZ hydrolase BABF1_RS05215 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BABF1_RS05230 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BABF1_RS05240 ENOG4105EMN RNA polymerase sigma factor BABF1_RS05265 ENOG4105C57 major facilitator superfamily BABF1_RS05270 ENOG4105C0R drug resistance transporter emrb qaca subfamily BABF1_RS05280 ENOG4105EEM helicase BABF1_RS05285 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BABF1_RS05310 ENOG4105K59 histidine triad (HIT) protein BABF1_RS05340 ENOG410905X membrane-flanked domain protein BABF1_RS05385 ENOG410905X membrane-flanked domain protein BABF1_RS05390 ENOG4105CKV Membrane BABF1_RS05395 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BABF1_RS05400 ENOG4105BZ4 penicillin-binding protein BABF1_RS05405 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BABF1_RS05415 ENOG4105C1Q protoporphyrinogen oxidase BABF1_RS05440 ENOG4105NA0 Transcriptional regulator BABF1_RS05455 ENOG4105ECB domain protein BABF1_RS05485 ENOG4106AXD BABF1_RS05490 ENOG4108RQ5 Beta-lactamase domain-containing protein BABF1_RS05495 ENOG4105DF9 Lipoate-protein, ligase BABF1_RS05505 ENOG4105CEY Amp-dependent synthetase and ligase BABF1_RS05535 ENOG4105CNA YD repeat protein BABF1_RS05570 ENOG4107TVP HD domain protein BABF1_RS05580 ENOG4108AEY RNA polymerase sigma factor BABF1_RS05585 ENOG41086D8 Transcriptional regulator BABF1_RS05600 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BABF1_RS05625 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BABF1_RS05630 ENOG4105C8Q Methyl-accepting chemotaxis BABF1_RS05650 ENOG4105ZU5 s-layer protein BABF1_RS05655 ENOG4107QP3 malate synthase g BABF1_RS05670 ENOG4105VEQ Cold shock protein BABF1_RS05685 ENOG4105XVF Competence transcription factor BABF1_RS05700 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BABF1_RS05705 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BABF1_RS05750 ENOG4105ERH Fumarylacetoacetate hydrolase BABF1_RS05775 ENOG4105CAQ asparagine synthetase BABF1_RS05780 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BABF1_RS05785 ENOG4105CH6 catalase BABF1_RS05790 ENOG4105BZU Histidine kinase BABF1_RS05810 ENOG4105QNR S1 RNA binding domain protein BABF1_RS05820 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BABF1_RS05830 ENOG4107AYK membrAne BABF1_RS05835 ENOG41073B9 BABF1_RS05845 ENOG4108KP7 hydrolase BABF1_RS05855 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BABF1_RS05880 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BABF1_RS05885 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BABF1_RS05900 ENOG4105C31 Tryptophanyl-tRNA synthetase BABF1_RS05915 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BABF1_RS05920 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BABF1_RS05930 ENOG4108JQ7 (ABC) transporter BABF1_RS05935 ENOG4105UQX Mate efflux family protein BABF1_RS05955 ENOG4108ZCF integral membrane protein BABF1_RS05965 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BABF1_RS05975 ENOG4105DPN Oligoendopeptidase f BABF1_RS05985 ENOG4108Z18 K06886 hemoglobin BABF1_RS05990 ENOG4105MIX Adenylate cyclase BABF1_RS06005 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BABF1_RS06010 ENOG4105EMS pseudouridine synthase BABF1_RS06030 ENOG4105K64 Glycosyl transferase, family 2 BABF1_RS06070 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BABF1_RS06075 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BABF1_RS06085 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BABF1_RS06135 ENOG4108WVJ 2'-5' rna ligase BABF1_RS06160 ENOG4105CK7 Sodium proline symporter BABF1_RS06165 ENOG4105CRQ synthase (Component I) BABF1_RS06170 ENOG4105DDQ anthranilate synthase BABF1_RS06265 ENOG4105C7S Dehydrogenase BABF1_RS06275 ENOG4105VZ8 Transcriptional regulator BABF1_RS06335 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BABF1_RS06345 ENOG4105DZ1 carboxypeptidase BABF1_RS06350 ENOG4105VFR signal peptidase BABF1_RS06385 ENOG4105C26 Dehydrogenase BABF1_RS06390 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BABF1_RS06395 ENOG4105F38 ABC transporter, permease BABF1_RS06400 ENOG4105D38 putrescine abc transporter BABF1_RS06405 ENOG4107RUE extracellular solute-binding protein family 1 BABF1_RS06415 ENOG4105EYF MMPL domain protein BABF1_RS06425 ENOG4108YBP pseudouridine synthase BABF1_RS06435 ENOG4105K4I Scp-like extracellular BABF1_RS06440 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BABF1_RS06445 ENOG4105CQB FAD linked oxidase domain protein BABF1_RS06460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BABF1_RS06465 ENOG4105BZU Histidine kinase BABF1_RS06470 ENOG4105JXH GntR family transcriptional regulator BABF1_RS06490 ENOG4106A3R peptidase BABF1_RS06500 ENOG4108QTI )-transporter BABF1_RS06505 ENOG4107TS3 membrane protein, TerC BABF1_RS06515 ENOG410681C small acid-soluble spore protein BABF1_RS06520 ENOG4108Z7G MaoC domain protein dehydratase BABF1_RS06540 ENOG4105CHR reductase BABF1_RS06550 ENOG4105MWK D-amino acid dehydrogenase, small subunit BABF1_RS06565 ENOG4105C4Y ABC transporter BABF1_RS06580 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BABF1_RS06595 ENOG4105E98 transcriptional regulator DeoR family BABF1_RS06615 ENOG4105PXI polysaccharide deacetylase BABF1_RS06625 ENOG4105BZU Histidine kinase BABF1_RS06630 ENOG41090MY MarR family Transcriptional regulator BABF1_RS06640 ENOG4106DF1 BABF1_RS06645 ENOG4105BZU Histidine kinase BABF1_RS06655 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BABF1_RS06660 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BABF1_RS06695 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BABF1_RS06715 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BABF1_RS06720 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BABF1_RS06725 ENOG4105CZV ABC transporter BABF1_RS06735 ENOG4105CJ1 ABC, transporter BABF1_RS06775 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BABF1_RS06780 ENOG4105EA8 2-Nitropropane dioxygenase BABF1_RS06785 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BABF1_RS06795 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BABF1_RS06815 ENOG4105NQC Flavodoxin BABF1_RS06840 ENOG4107QMU Mate efflux family protein BABF1_RS06845 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BABF1_RS06880 ENOG41063Y9 BABF1_RS06885 ENOG4105KBJ sporulation protein ytfj BABF1_RS06910 ENOG4105CM2 brancheD-chain amino acid aminotransferase BABF1_RS06915 ENOG4105C7K acetolactate synthase BABF1_RS06920 ENOG4108ZP8 Acetolactate synthase small subunit BABF1_RS06925 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BABF1_RS06935 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BABF1_RS06960 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BABF1_RS06995 ENOG4107RVV histidinol phosphate phosphatase, hisj family BABF1_RS07010 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BABF1_RS07015 ENOG4105E0M Sulfatase BABF1_RS07025 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BABF1_RS07045 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BABF1_RS07050 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BABF1_RS07060 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BABF1_RS07065 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BABF1_RS07075 ENOG4105C8J )-transporter BABF1_RS07095 ENOG4105DFD Na H antiporter BABF1_RS07115 ENOG4105ENE Histidine kinase BABF1_RS07120 ENOG4105WH1 Two component transcriptional regulator luxr family BABF1_RS07140 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BABF1_RS07165 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BABF1_RS07185 ENOG4105CJ3 phosphate transporter BABF1_RS07190 ENOG4107GRR phosphate transport regulator BABF1_RS07195 ENOG4105BZ4 penicillin-binding protein BABF1_RS07215 ENOG4105I3N Conserved Protein BABF1_RS07230 ENOG4105BZU Histidine kinase BABF1_RS07265 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BABF1_RS07270 ENOG4105DZ1 carboxypeptidase BABF1_RS07275 ENOG4108JIC nucleoside recognition domain protein BABF1_RS07285 ENOG4105FE9 pseudouridine synthase BABF1_RS07295 ENOG4107TWT Cytochrome c biogenesis protein BABF1_RS07300 ENOG4105CRE cytochrome C BABF1_RS07305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BABF1_RS07310 ENOG4105BZU Histidine kinase BABF1_RS07315 ENOG4108WBT adenosyltransferase BABF1_RS07330 ENOG4108SAX Membrane BABF1_RS07340 ENOG4105T7X BABF1_RS07345 ENOG4105C9U ATP-dependent DNA helicase RecQ BABF1_RS07350 ENOG4105I7S Abortive infection protein BABF1_RS07365 ENOG4107X2D transcriptional regulator, merr family BABF1_RS07370 ENOG4108S6Z Negative regulator of genetic competence BABF1_RS07395 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BABF1_RS07400 ENOG4105HDK L-asparaginase BABF1_RS07435 ENOG4105S2F BABF1_RS07440 ENOG41065D1 BABF1_RS07470 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BABF1_RS07485 ENOG4105XXQ heptaprenyl diphosphate synthase component I BABF1_RS07495 ENOG4105EAH synthase BABF1_RS07515 ENOG4105CIH Imidazole acetol-phosphate transaminase BABF1_RS07520 ENOG41068YB TPR repeat-containing protein BABF1_RS07535 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BABF1_RS07540 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BABF1_RS07545 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BABF1_RS07575 ENOG4108JYZ YitT family BABF1_RS07580 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BABF1_RS07595 ENOG4105FJR Lmbe family BABF1_RS07600 ENOG4105CPK Glycosyl transferase (Group 1 BABF1_RS07640 ENOG4105YAC BABF1_RS07660 ENOG4105CSM endonuclease III BABF1_RS07670 ENOG4105BZ4 penicillin-binding protein BABF1_RS07725 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BABF1_RS07735 ENOG4105DVT helicase BABF1_RS07740 ENOG4105CTD carboxy-peptidase BABF1_RS07755 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BABF1_RS07770 ENOG4105C2W permease BABF1_RS07775 ENOG4105DHF Membrane BABF1_RS07785 ENOG410890F Dynamin family BABF1_RS07795 ENOG4108W0I acetyltransferase BABF1_RS07805 ENOG4105KHC sulfurtransferase BABF1_RS07905 ENOG4108SZE gCN5-related N-acetyltransferase BABF1_RS07925 ENOG41081VK Ribonuclease BABF1_RS07990 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BABF1_RS08000 ENOG4107RWR Sodium hydrogen exchanger BABF1_RS08005 ENOG4105CN5 Metallo-Beta-Lactamase BABF1_RS08010 ENOG4108Z5V transcriptional regulator, merr family BABF1_RS08020 ENOG4105H67 Protein of unknown function (DUF421) BABF1_RS08025 ENOG41080C8 DUF218 domain BABF1_RS08080 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BABF1_RS08090 ENOG4107R0U MotA TolQ exbB proton channel BABF1_RS08095 ENOG4105ER2 Ompa motb domain protein BABF1_RS08100 ENOG4107YTP response regulator receiver protein BABF1_RS08110 ENOG4105DD5 Flagellar motor switch protein BABF1_RS08125 ENOG4105BZU Histidine kinase BABF1_RS08145 ENOG4105E1Q flagellar hook-associated protein BABF1_RS08170 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BABF1_RS08175 ENOG4108ZC9 flagellar basal-body rod protein flgc BABF1_RS08180 ENOG41075Z6 flagellar hook-basal body complex protein fliE BABF1_RS08190 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BABF1_RS08225 ENOG4105BZE flagellar hook protein, FlgE BABF1_RS08240 ENOG4107R88 Chemotaxis protein (CheV) BABF1_RS08250 ENOG4105K64 Glycosyl transferase, family 2 BABF1_RS08290 ENOG4105I03 Flagellin BABF1_RS08295 ENOG4105E4C Lytic transglycosylase catalytic BABF1_RS08310 ENOG4105DD5 Flagellar motor switch protein BABF1_RS08320 ENOG4105CN7 Flagellar biosynthetic protein FliP BABF1_RS08325 ENOG4105VS8 Flagellar biosynthetic protein fliq BABF1_RS08335 ENOG4105D00 flagellar biosynthetic protein flhB BABF1_RS08340 ENOG4105D7B Flagellar biosynthesis protein flha BABF1_RS08345 ENOG4105FZW flagellar biosynthesis regulator FlhF BABF1_RS08350 ENOG4105KTQ flagellar basal-body rod protein BABF1_RS08355 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BABF1_RS08380 ENOG4108RZE Tetr family transcriptional regulator BABF1_RS08400 ENOG4105KAC Antibiotic biosynthesis monooxygenase BABF1_RS08430 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BABF1_RS08435 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BABF1_RS08440 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BABF1_RS08445 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BABF1_RS08485 ENOG4105CVJ phosphoglycerate mutase BABF1_RS08515 ENOG4105CAQ asparagine synthetase BABF1_RS08535 ENOG4105PGM cation diffusion facilitator family transporter BABF1_RS08545 ENOG4105DRR Transcriptional regulator, GntR family BABF1_RS08550 ENOG4108UZ3 Transporter BABF1_RS08555 ENOG4105CKI cobalamin synthesis protein BABF1_RS08560 ENOG4108PJD permease BABF1_RS08575 ENOG4105DFD Na H antiporter BABF1_RS08580 ENOG4105C9Q fumarate hydratase class II BABF1_RS08605 ENOG4105EC3 peptidase S51, dipeptidase E BABF1_RS08625 ENOG4107QIV Cytochrome c biogenesis protein BABF1_RS08655 ENOG4106BRA Membrane BABF1_RS08690 ENOG4105CJ1 ABC, transporter BABF1_RS08710 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BABF1_RS08720 ENOG4108IJ0 Aspartate ammonia-lyase BABF1_RS08725 ENOG4105C6K Malic enzyme BABF1_RS08785 ENOG4105FVX BABF1_RS08825 ENOG4105CSR polyphosphate kinase 2 BABF1_RS08830 ENOG4105DXI Major Facilitator superfamily BABF1_RS08845 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BABF1_RS08860 ENOG4105C6T cysteine synthase BABF1_RS08880 ENOG4105C8J )-transporter BABF1_RS08890 ENOG4105X5K response regulator receiver protein BABF1_RS08895 ENOG4105H67 Protein of unknown function (DUF421) BABF1_RS08910 ENOG4106KE4 Dehydrogenase BABF1_RS08925 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BABF1_RS08930 ENOG4105CHR reductase BABF1_RS08935 ENOG4105CM2 brancheD-chain amino acid aminotransferase BABF1_RS08940 ENOG4105C7K acetolactate synthase BABF1_RS08945 ENOG4108ZP8 Acetolactate synthase small subunit BABF1_RS08950 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BABF1_RS08960 ENOG4105C7B Threonine dehydratase BABF1_RS08990 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BABF1_RS09000 ENOG4105DY9 regulatoR BABF1_RS09005 ENOG4105CYC Transferase BABF1_RS09025 ENOG4105F6J Alpha beta hydrolase fold BABF1_RS09030 ENOG4108J59 Extracellular solute-binding protein, family 5 BABF1_RS09060 ENOG41068WN BABF1_RS09080 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BABF1_RS09085 ENOG4105C72 UPF0176 protein BABF1_RS09095 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BABF1_RS09125 ENOG4107RHR regulatoR BABF1_RS09135 ENOG4105D9N nucleoside BABF1_RS09140 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BABF1_RS09175 ENOG4107RAQ aminopeptidase BABF1_RS09180 ENOG4107STQ Multicopper oxidase BABF1_RS09225 ENOG4108T5E Copper resistance protein BABF1_RS09230 ENOG4105KTB nuclear export factor GLE1 BABF1_RS09240 ENOG4107RT3 EamA-like transporter family BABF1_RS09245 ENOG4105GZI Transcriptional regulator BABF1_RS09250 ENOG4108Z40 Transcriptional regulator BABF1_RS09255 ENOG4107ZXU DSBA oxidoreductase BABF1_RS09260 ENOG4108TVJ Nitroreductase BABF1_RS09265 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BABF1_RS09270 ENOG4106F5Q Membrane BABF1_RS09275 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BABF1_RS09285 ENOG4105CKI cobalamin synthesis protein BABF1_RS09305 ENOG4108Z7G MaoC domain protein dehydratase BABF1_RS09310 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BABF1_RS09320 ENOG4105C0Z ABC transporter BABF1_RS09325 ENOG4108IV0 ABC, transporter BABF1_RS09330 ENOG4105C32 Amino acid ABC transporter (Permease) BABF1_RS09340 ENOG4105SKE transcriptional Regulator LysR family BABF1_RS09360 ENOG4105YGB Transcriptional regulator BABF1_RS09370 ENOG4105C4M (Ubiquinol oxidase) subunit I BABF1_RS09375 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BABF1_RS09380 ENOG4108JJ9 ABC, transporter BABF1_RS09385 ENOG4108JJ8 (ABC) transporter BABF1_RS09435 ENOG4105EFI regulatoR BABF1_RS09460 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BABF1_RS09465 ENOG4108ZJ4 polysaccharide deacetylase BABF1_RS09485 ENOG4105D6E homoserine dehydrogenase BABF1_RS09510 ENOG4108KGH TRANSCRIPTIONal BABF1_RS09520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BABF1_RS09525 ENOG4105BZU Histidine kinase BABF1_RS09530 ENOG4107VMI polysaccharide deacetylase BABF1_RS09540 ENOG4105KT7 mgtC SapB transporter BABF1_RS09545 ENOG4105VRR gCN5-related N-acetyltransferase BABF1_RS09555 ENOG4105DUU IucA IucC family protein BABF1_RS09560 ENOG4105CEY Amp-dependent synthetase and ligase BABF1_RS09575 ENOG4108WBH protein TIM barrel BABF1_RS09580 ENOG4105YWU small acid-soluble spore protein BABF1_RS09590 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BABF1_RS09640 ENOG4105KRN Transcriptional regulator, abrb family BABF1_RS09650 ENOG4105YVS arsR family transcriptional regulator BABF1_RS09655 ENOG4107SET aldo keto reductase BABF1_RS09685 ENOG4105C8Q Methyl-accepting chemotaxis BABF1_RS09700 ENOG4108K88 Membrane BABF1_RS09705 ENOG4108WPJ Ferritin-like domain BABF1_RS09720 ENOG4105DEN Luciferase family BABF1_RS09740 ENOG4107QM2 Aldo Keto reductase BABF1_RS09745 ENOG4105CKI cobalamin synthesis protein BABF1_RS09800 ENOG4105DSE periplasmic solute binding protein BABF1_RS09805 ENOG4105K4T epimerase BABF1_RS09815 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BABF1_RS09840 ENOG4105CVJ phosphoglycerate mutase BABF1_RS09860 ENOG4107T5V SNARE associated Golgi BABF1_RS09875 ENOG4108PJD permease BABF1_RS09885 ENOG4108S4H thioesterase Superfamily protein BABF1_RS09895 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BABF1_RS09915 ENOG4105SXS Protein of unknown function (DUF456) BABF1_RS09920 ENOG4105C37 (CBS) domain BABF1_RS09940 ENOG4108Z7R Chaperone CsaA BABF1_RS09960 ENOG4108ZRV stage ii sporulation protein p BABF1_RS09970 ENOG4108VXD carboxy-peptidase BABF1_RS09980 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BABF1_RS10005 ENOG4108X4Q Hydrolase BABF1_RS10015 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BABF1_RS10020 ENOG4107RBS Methyltransferase BABF1_RS10035 ENOG41087PP glycosyltransferase MGT family BABF1_RS10040 ENOG4108JYZ YitT family BABF1_RS10045 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BABF1_RS10070 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BABF1_RS10120 ENOG4105KBJ sporulation protein ytfj BABF1_RS10145 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BABF1_RS10170 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BABF1_RS10180 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BABF1_RS10185 ENOG4105EMN RNA polymerase sigma factor BABF1_RS10210 ENOG4108V06 Glutathione peroxidase BABF1_RS10225 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BABF1_RS10245 ENOG4108IUE nitrate reductase beta subunit BABF1_RS10250 ENOG4105R3A Nitrate reductase BABF1_RS10275 ENOG4107V6Q Cyclic nucleotide-binding domain BABF1_RS10280 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BABF1_RS10285 ENOG4105D06 uba thif-type nad fad binding protein BABF1_RS10290 ENOG4105CVM Molybdenum cofactor synthesis domain protein BABF1_RS10295 ENOG4108ZAF Molybdopterin BABF1_RS10320 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BABF1_RS10325 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BABF1_RS10330 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BABF1_RS10335 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BABF1_RS10340 ENOG4108IFG nitrite reductase, (NAD(P)H) BABF1_RS10345 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BABF1_RS10380 ENOG4105MCT stage V sporulation protein S BABF1_RS10395 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BABF1_RS10415 ENOG4105C5H ABC transporter BABF1_RS10430 ENOG4108UUM single-stranded DNA-binding protein BABF1_RS10460 ENOG4107YX5 Pfam:DUF548 BABF1_RS10465 ENOG4105C75 arginyL-tRNA synthetase BABF1_RS10490 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BABF1_RS10510 ENOG4105C5S asparaginyl-tRNA synthetase BABF1_RS10530 ENOG4105EC2 ftsk spoIIIe BABF1_RS10600 ENOG4105BZW Glycerate kinase BABF1_RS10605 ENOG4107QPK )-transporter BABF1_RS10610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BABF1_RS10615 ENOG41062D9 Histidine kinase BABF1_RS10630 ENOG4105C8J )-transporter BABF1_RS10650 ENOG4107XGZ Hydrolase BABF1_RS10655 ENOG4105CY2 Citrate transporter BABF1_RS10660 ENOG4105C0A alcohol dehydrogenase BABF1_RS10675 ENOG4105KD7 acetyltransferase BABF1_RS10705 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BABF1_RS10725 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BABF1_RS10740 ENOG4107RVG penicillin-binding protein BABF1_RS10745 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BABF1_RS10750 ENOG4105E9Q Acyl-transferase BABF1_RS10755 ENOG4108UT2 hemolysin iii BABF1_RS10765 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BABF1_RS10775 ENOG4108RCR degv family BABF1_RS10780 ENOG4105E8R UPF0173 metal-dependent hydrolase BABF1_RS10785 ENOG4108KF3 Electron transport protein SCO1 SenC BABF1_RS10790 ENOG4107Y70 Heat shock protein BABF1_RS10795 ENOG4105CAQ asparagine synthetase BABF1_RS10810 ENOG4108MES Periplasmic binding protein BABF1_RS10815 ENOG4105F0I Aminotransferase BABF1_RS10850 ENOG4105D8X mechanosensitive ion channel BABF1_RS10855 ENOG4105BZU Histidine kinase BABF1_RS10860 ENOG4105WH1 Two component transcriptional regulator luxr family BABF1_RS10895 ENOG4105CMG Carbohydrate kinase BABF1_RS10900 ENOG4105CMG Carbohydrate kinase BABF1_RS10930 ENOG4108IJ8 ABC transporter BABF1_RS10935 ENOG4105E90 ABC transporter BABF1_RS10970 ENOG4105C37 (CBS) domain BABF1_RS10995 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BABF1_RS11010 ENOG4107S4Y M20 DapE family protein YgeY BABF1_RS11015 ENOG4108TSC N-acetyltransferase BABF1_RS11020 ENOG4108JUB Transcriptional regulator BABF1_RS11025 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BABF1_RS11065 ENOG4108N23 SpoOM-related protein BABF1_RS11070 ENOG410841Q phosphoesterase PA-phosphatase related protein BABF1_RS11080 ENOG4105SZ6 Thioredoxin BABF1_RS11095 ENOG4108IBT Inherit from COG: transposase BABF1_RS11200 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BABF1_RS11240 ENOG4105BZ4 penicillin-binding protein BABF1_RS11245 ENOG4105CZM Major Facilitator BABF1_RS11250 ENOG4105W8X HesB YadR YfhF-family protein BABF1_RS11260 ENOG4105DXD 2-methylcitrate dehydratase BABF1_RS11265 ENOG4105CR4 methylisocitrate lyase BABF1_RS11270 ENOG4105C1G acyl-Coa dehydrogenase BABF1_RS11275 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BABF1_RS11285 ENOG4105N14 lysine exporter protein LysE YggA BABF1_RS11290 ENOG4105E39 Enoyl-CoA hydratase BABF1_RS11305 ENOG4107RFY SbcCD D subunit BABF1_RS11310 ENOG4105EYH Exonuclease BABF1_RS11330 ENOG4105FCD Major Facilitator BABF1_RS11335 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BABF1_RS11340 ENOG4105E4F Isochorismate synthase BABF1_RS11345 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BABF1_RS11350 ENOG4105WQI isochorismatase BABF1_RS11360 ENOG4105WQT MbtH domain protein BABF1_RS11365 ENOG4105C0R drug resistance transporter emrb qaca subfamily BABF1_RS11380 ENOG4105K70 DNA-binding protein BABF1_RS11420 ENOG4105FE9 pseudouridine synthase BABF1_RS11425 ENOG4105C22 threonyL-tRNA synthetase BABF1_RS11440 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BABF1_RS11465 ENOG4108D32 Methyltransferase BABF1_RS11495 ENOG41081I9 integral membrane protein BABF1_RS11510 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BABF1_RS11520 ENOG4105EYF MMPL domain protein BABF1_RS11545 ENOG4105WCN acetyltransferase BABF1_RS11575 ENOG4105C1Q protoporphyrinogen oxidase BABF1_RS11585 ENOG41068WN BABF1_RS11595 ENOG4105VEQ Cold shock protein BABF1_RS11615 ENOG410667J hydrolase BABF1_RS11655 ENOG4107V2S Transcriptional regulator BABF1_RS11660 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BABF1_RS11675 ENOG4105DND Transcriptional regulator BABF1_RS11680 ENOG4108RPX mosc domain containing protein BABF1_RS11695 ENOG4105BZ1 (ABC) transporter BABF1_RS11700 ENOG4105BZ1 (ABC) transporter BABF1_RS11720 ENOG4108JCI Transcriptional regulator BABF1_RS11750 ENOG4108KPJ rna polymerase sigma factor BABF1_RS11770 ENOG4105F32 YngK protein BABF1_RS11795 ENOG4105RD7 BadF BadG BcrA BcrD BABF1_RS11805 ENOG4107STF Involved in phosphonate degradation (By similarity) BABF1_RS11825 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BABF1_RS11840 ENOG4105C1J atp-dependent rna helicase BABF1_RS11855 ENOG4108RZE Tetr family transcriptional regulator BABF1_RS11875 ENOG41088CC tellurite resistance protein tehB BABF1_RS11885 ENOG4108I0C methyltransferase BABF1_RS11890 ENOG4107RA9 decarboxylase BABF1_RS11895 ENOG41090HR transcriptional regulator BABF1_RS11925 ENOG4105CIN aminoacyl-histidine dipeptidase BABF1_RS11950 ENOG4107RF6 penicillin-binding protein BABF1_RS11955 ENOG4107RF6 penicillin-binding protein BABF1_RS11970 ENOG4105ETE Transcriptional regulator (LacI family BABF1_RS11980 ENOG4105CK5 oxidoreductase BABF1_RS12005 ENOG4105D2N Aldolase BABF1_RS12025 ENOG4105CGH 5'-nucleotidase BABF1_RS12040 ENOG4105VZ8 Transcriptional regulator BABF1_RS12055 ENOG4108VXD carboxy-peptidase BABF1_RS12075 ENOG41067SE Tetr family transcriptional regulator BABF1_RS12080 ENOG4105C5H ABC transporter BABF1_RS12090 ENOG4105BZU Histidine kinase BABF1_RS12105 ENOG4106ANW SMI1_KNR4 BABF1_RS12130 ENOG4105CJ1 ABC, transporter BABF1_RS12140 ENOG4107Z3H Transcriptional regulator, TetR family BABF1_RS12155 ENOG4105C1G acyl-Coa dehydrogenase BABF1_RS12160 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BABF1_RS12165 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BABF1_RS12170 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BABF1_RS12175 ENOG4105E39 Enoyl-CoA hydratase BABF1_RS12180 ENOG4107QX3 carboxylase BABF1_RS12185 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BABF1_RS12195 ENOG4105WCN acetyltransferase BABF1_RS12200 ENOG4105DBI uridine monophosphokinase BABF1_RS12215 ENOG4105DZ1 carboxypeptidase BABF1_RS12230 ENOG4105T9C HD domain BABF1_RS12240 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BABF1_RS12280 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BABF1_RS12280 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BABF1_RS12295 ENOG4105FQP Beta-lactamase BABF1_RS12305 ENOG4107Y80 Major Facilitator superfamily BABF1_RS12320 ENOG4105CUV Homoserine Kinase BABF1_RS12355 ENOG4105CPQ Dehydrogenase BABF1_RS12460 ENOG4105ETU transcriptional activator (TenA BABF1_RS12555 ENOG410667J hydrolase BABF1_RS12565 ENOG4105BZU Histidine kinase BABF1_RS12570 ENOG4107RF6 penicillin-binding protein BABF1_RS12590 ENOG4108JJB ABC transporter BABF1_RS12605 ENOG4108HGU Histidine kinase BABF1_RS12620 ENOG4105CB2 alcohol dehydrogenase BABF1_RS12625 ENOG4105CJN penicillin-binding protein BABF1_RS12635 ENOG4105FQP Beta-lactamase BABF1_RS12670 ENOG4108V4B ThiJ pfpI BABF1_RS12700 ENOG4107Y80 Major Facilitator superfamily BABF1_RS12715 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BABF1_RS12765 ENOG4105FCD Major Facilitator BABF1_RS12780 ENOG4105E09 nadh pyrophosphatase BABF1_RS12785 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BABF1_RS12790 ENOG4108Z4K mutator MutT protein BABF1_RS12825 ENOG4108XI2 Domain of unknown function (DUF1963) BABF1_RS12855 ENOG4105KWG Pfam:DUF1696 BABF1_RS12890 ENOG4105PKS Excinuclease abc c subunit domain protein BABF1_RS12930 ENOG4107VFR oxidoreductase BABF1_RS12955 ENOG4105PAD Hydrolase BABF1_RS12975 ENOG4105DY8 decarboxylase BABF1_RS12990 ENOG4108IUM Glycogen debranching enzyme BABF1_RS13015 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BABF1_RS13025 ENOG4105FDR Membrane BABF1_RS13060 ENOG4108V3A UPF0421 protein BABF1_RS13080 ENOG4105MSI germination protein ypeb BABF1_RS13100 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BABF1_RS13105 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BABF1_RS13110 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BABF1_RS13115 ENOG4107Z3H Transcriptional regulator, TetR family BABF1_RS13145 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BABF1_RS13160 ENOG4105E98 transcriptional regulator DeoR family BABF1_RS13180 ENOG41062ES Transcriptional regulator BABF1_RS13200 ENOG4107QKR Dehydrogenase BABF1_RS13210 ENOG4107RUY (E1 component), alpha subunit BABF1_RS13220 ENOG4105E1F short-chain dehydrogenase reductase BABF1_RS13225 ENOG4105RHY Pfam:UPF0157 BABF1_RS13255 ENOG4107SQ8 Glycine betaine BABF1_RS13260 ENOG4108IJ7 Glycine betaine BABF1_RS13285 ENOG4105E66 phosphoriboisomerase A BABF1_RS13290 ENOG41082BV acetyltransferase BABF1_RS13295 ENOG4108M1A Chitin-binding protein BABF1_RS13330 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BABF1_RS13360 ENOG4108Z7F N-acetyltransferase BABF1_RS13380 ENOG4105EEM helicase BABF1_RS13400 ENOG4105C9U ATP-dependent DNA helicase RecQ BABF1_RS13445 ENOG4108M1A Chitin-binding protein BABF1_RS13465 ENOG4105BZG amino acid carrier protein BABF1_RS13470 ENOG4105C26 Dehydrogenase BABF1_RS13475 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BABF1_RS13480 ENOG4105CTU Proline racemase BABF1_RS13485 ENOG4105CTU Proline racemase BABF1_RS13490 ENOG41080HI glycine oxidase BABF1_RS13530 ENOG4107T5V SNARE associated Golgi BABF1_RS13545 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BABF1_RS13550 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BABF1_RS13565 ENOG4105DTQ mandelate racemase muconate lactonizing BABF1_RS13610 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BABF1_RS13615 ENOG4105BZU Histidine kinase BABF1_RS13620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BABF1_RS13655 ENOG4105DPN Oligoendopeptidase f BABF1_RS13670 ENOG4105EPR degv family BABF1_RS13710 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BABF1_RS13715 ENOG4106K7D Major facilitator family transporter BABF1_RS13735 ENOG4107BMA Transglycosylase associated protein BABF1_RS13750 ENOG41089UC methyltransferase, type 11 BABF1_RS13785 ENOG4105CHM Aminotransferase BABF1_RS13815 ENOG4105DVE abc transporter atp-binding protein BABF1_RS13855 ENOG4105C02 permease BABF1_RS13865 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BABF1_RS13870 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BABF1_RS13875 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BABF1_RS13900 ENOG4105E09 nadh pyrophosphatase BABF1_RS13920 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BABF1_RS13970 ENOG4107VC0 DNA alkylation repair enzyme BABF1_RS13980 ENOG4107VMI polysaccharide deacetylase BABF1_RS13990 ENOG4108ZCF integral membrane protein BABF1_RS13995 ENOG4105E0M Sulfatase BABF1_RS14000 ENOG4105C5H ABC transporter BABF1_RS14015 ENOG41082JN Transcriptional regulator BABF1_RS14035 ENOG4105CIH Imidazole acetol-phosphate transaminase BABF1_RS14040 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BABF1_RS14045 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BABF1_RS14080 ENOG41069ER domain protein BABF1_RS14090 ENOG4105EMN RNA polymerase sigma factor BABF1_RS14115 ENOG4105D4B ABC, transporter BABF1_RS14125 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BABF1_RS14135 ENOG4105DKT Transcriptional regulator BABF1_RS14140 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BABF1_RS14150 ENOG41061GT Aldolase BABF1_RS14170 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BABF1_RS14200 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BABF1_RS14205 ENOG4105II7 pyrroline-5-carboxylate reductase BABF1_RS14215 ENOG4107258 Transcriptional regulator BABF1_RS14225 ENOG4105E0Y RtcB Protein BABF1_RS14230 ENOG4105ECK Fatty Acid Desaturase BABF1_RS14235 ENOG4105G6Z alkaline phosphatase BABF1_RS14245 ENOG4105VMP Transcriptional regulator BABF1_RS14260 ENOG41090T1 Membrane BABF1_RS14270 ENOG4108WCX response regulator BABF1_RS14280 ENOG41068WN BABF1_RS14305 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BABF1_RS14330 ENOG4105CKK Glycosyl transferase, family 2 BABF1_RS14355 ENOG4105CKK Glycosyl transferase, family 2 BABF1_RS14365 ENOG4105C8Y Acetylornithine aminotransferase BABF1_RS14405 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BABF1_RS14415 ENOG4108TVJ Nitroreductase BABF1_RS14420 ENOG4105FS7 Transcriptional regulator BABF1_RS14455 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BABF1_RS14465 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BABF1_RS14495 ENOG4108XET gCN5-related N-acetyltransferase BABF1_RS14575 ENOG410635A Membrane BABF1_RS14580 ENOG4105KNA -acetyltransferase BABF1_RS14585 ENOG4108IQI permease BABF1_RS14595 ENOG4105F1N DNA alkylation repair BABF1_RS14630 ENOG4107RF6 penicillin-binding protein BABF1_RS14640 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BABF1_RS14675 ENOG4105P4J Allophanate hydrolase, subunit 1 BABF1_RS14680 ENOG4107258 Transcriptional regulator BABF1_RS14690 ENOG4106N3A copper homeostasis protein cutc BABF1_RS14695 ENOG4108ZRV stage ii sporulation protein p BABF1_RS14700 ENOG4108ZHR arsR family transcriptional regulator BABF1_RS14710 ENOG4105FDT acyl-CoA dehydrogenase BABF1_RS14725 ENOG4105DWD nucleoside recognition domain protein BABF1_RS14755 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BABF1_RS14815 ENOG4105E2A Dehydrogenase BABF1_RS14830 ENOG4108IJ0 Aspartate ammonia-lyase BABF1_RS14835 ENOG4105HDK L-asparaginase BABF1_RS14840 ENOG4108IMY Transcriptional regulator BABF1_RS14850 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BABF1_RS14855 ENOG4105CUB amino acid BABF1_RS14865 ENOG4105II7 pyrroline-5-carboxylate reductase BABF1_RS14875 ENOG4105C6K Malic enzyme BABF1_RS14890 ENOG4108Q8B Spore germination protein BABF1_RS14910 ENOG4105CSV Glutaminase BABF1_RS14945 ENOG4105CGH 5'-nucleotidase BABF1_RS14950 ENOG4105CH6 catalase BABF1_RS14960 ENOG4105CHJ isochorismatase hydrolase BABF1_RS14985 ENOG41090MY MarR family Transcriptional regulator BABF1_RS15020 ENOG4108606 TspO/MBR family BABF1_RS15025 ENOG4105CVP deoxyribo-dipyrimidine photolyase BABF1_RS15040 ENOG4108TWJ NADH dehydrogenase subunit 5 BABF1_RS15045 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BABF1_RS15060 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BABF1_RS15065 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BABF1_RS15070 ENOG4105DSE periplasmic solute binding protein BABF1_RS15075 ENOG4105CC5 ABC transporter BABF1_RS15080 ENOG4105DIK (ABC) transporter BABF1_RS15110 ENOG4105D6J arsenicaL-resistance protein BABF1_RS15115 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BABF1_RS15120 ENOG41085FC arsR family transcriptional regulator BABF1_RS15135 ENOG4105F7F Chaperone BABF1_RS15145 ENOG4105CHR reductase BABF1_RS15150 ENOG4108YXU transcriptional regulator AsnC family BABF1_RS15225 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BABF1_RS15230 ENOG4105C0R drug resistance transporter emrb qaca subfamily BABF1_RS15240 ENOG4105IIP Membrane BABF1_RS15255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BABF1_RS15260 ENOG41062D9 Histidine kinase BABF1_RS15285 ENOG4105K6H D-cysteine desulfhydrase BABF1_RS15305 ENOG4105VZ8 Transcriptional regulator BABF1_RS15320 ENOG4108NNI Beta-lactamase domain-containing protein BABF1_RS15325 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BABF1_RS15335 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BABF1_RS15340 ENOG4105JQZ Methyltransferase BABF1_RS15355 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BABF1_RS15360 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BABF1_RS15375 ENOG4105BZU Histidine kinase BABF1_RS15390 ENOG4108U05 Transcriptional regulator BABF1_RS15405 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BABF1_RS15410 ENOG4105DJB Major Facilitator Superfamily BABF1_RS15415 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BABF1_RS15420 ENOG4107QR9 Iron-sulfur cluster binding protein BABF1_RS15430 ENOG4106P55 Transcriptional regulator BABF1_RS15440 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BABF1_RS15475 ENOG4105TRI Hydrolase BABF1_RS15505 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BABF1_RS15535 ENOG4107QJQ Mate efflux family protein BABF1_RS15555 ENOG4105EQ0 Major Facilitator superfamily BABF1_RS15560 ENOG4108JGH Tetr family transcriptional regulator BABF1_RS15575 ENOG4105C44 Serine transporter BABF1_RS15580 ENOG4105EJQ L-serine dehydratase BABF1_RS15595 ENOG4108JPW Aminotransferase BABF1_RS15620 ENOG4105DVH amino acid BABF1_RS15635 ENOG4108JQ1 Dehydrogenase BABF1_RS15655 ENOG4108AEY RNA polymerase sigma factor BABF1_RS15670 ENOG41082W1 Cupin 2, conserved barrel domain protein BABF1_RS15675 ENOG410874W AraC family transcriptional regulator BABF1_RS15725 ENOG4108ISG Major Facilitator BABF1_RS15735 ENOG4107MII Sugar-specific transcriptional regulator TrmB BABF1_RS15740 ENOG4105CZM Major Facilitator BABF1_RS15760 ENOG4105DA5 (ABC) transporter BABF1_RS15765 ENOG41069JR BABF1_RS15775 ENOG4105RXJ BABF1_RS15780 ENOG4105KPY Small multidrug resistance protein BABF1_RS15785 ENOG4105KBX Transcriptional regulator, TetR family BABF1_RS15795 ENOG4105CRW Short chain fatty acid transporter BABF1_RS15805 ENOG4105DYS nad(p)h dehydrogenase (quinone) BABF1_RS15835 ENOG4108JJB ABC transporter BABF1_RS15840 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BABF1_RS15865 ENOG4108K8S endonuclease I BABF1_RS15880 ENOG41067QW Transcriptional regulator BABF1_RS15890 ENOG4108Z66 YbaK ebsC protein BABF1_RS15895 ENOG4105CUT histidyl-tRNA synthetase BABF1_RS15910 ENOG4105KVH Transcriptional regulator BABF1_RS15915 ENOG4108RCM Nitroreductase BABF1_RS15935 ENOG4108PSK reductase BABF1_RS15945 ENOG4105CJ1 ABC, transporter BABF1_RS16005 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BABF1_RS16010 ENOG4105DKQ ROK family BABF1_RS16015 ENOG4106UW1 Major Facilitator superfamily BABF1_RS16020 ENOG4108UW5 maltose o-acetyltransferase BABF1_RS16030 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BABF1_RS16035 ENOG4105C31 Tryptophanyl-tRNA synthetase BABF1_RS16040 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BABF1_RS16060 ENOG4105DMQ Methyltransferase BABF1_RS16070 ENOG4105EV4 Multidrug resistance protein mdtH BABF1_RS16100 ENOG4105C37 (CBS) domain BABF1_RS16115 ENOG4105DDN Pentapeptide repeat-containing protein BABF1_RS16120 ENOG4105XDF Protein of unknown function (DUF1272) BABF1_RS16125 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BABF1_RS16130 ENOG4105CMG Carbohydrate kinase BABF1_RS16135 ENOG4105C6Z Gluconate BABF1_RS16140 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BABF1_RS16155 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BABF1_RS16160 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BABF1_RS16165 ENOG4105CIS alcohol dehydrogenase BABF1_RS16170 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BABF1_RS16185 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BABF1_RS16190 ENOG4105D4Y metalloprotease BABF1_RS16210 ENOG4105CV8 reductase BABF1_RS16215 ENOG4105F27 Major Facilitator BABF1_RS16230 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BABF1_RS16235 ENOG4105C44 Serine transporter BABF1_RS16265 ENOG4105KVH Transcriptional regulator BABF1_RS16270 ENOG4108TZY GntR Family Transcriptional Regulator BABF1_RS16275 ENOG4105D9R oxidoreductase BABF1_RS16280 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BABF1_RS16285 ENOG4105KVH Transcriptional regulator BABF1_RS16290 ENOG4105KVH Transcriptional regulator BABF1_RS16325 ENOG4105JAB phenazine biosynthesis protein, phzf family BABF1_RS16335 ENOG4105CHR reductase BABF1_RS16355 ENOG4105KVH Transcriptional regulator BABF1_RS16425 ENOG4105KAF membrAne BABF1_RS16450 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BABF1_RS16465 ENOG4107YXZ hydrolase, family 25 BABF1_RS16490 ENOG4105ED2 Beta-lactamase BABF1_RS16500 ENOG4105H3G oxidoreductase BABF1_RS16535 ENOG4105CIS alcohol dehydrogenase BABF1_RS16570 ENOG4108TN2 lmbE family BABF1_RS16580 ENOG4107R3E Citrate transporter BABF1_RS16600 ENOG4108MES Periplasmic binding protein BABF1_RS16605 ENOG4105EHG Permease protein BABF1_RS16610 ENOG4105DQ5 transport system permease protein BABF1_RS16615 ENOG4105NX3 Membrane BABF1_RS16620 ENOG4107ZY0 Phenazine biosynthesis-like protein BABF1_RS16640 ENOG4107CUJ Protein of unknown function (DUF2690) BABF1_RS16650 ENOG4107V2S Transcriptional regulator BABF1_RS16670 ENOG4105C98 muts2 protein BABF1_RS16685 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BABF1_RS16690 ENOG4105DPN Oligoendopeptidase f BABF1_RS16695 ENOG4108A04 Beta-lactamase BABF1_RS16725 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BABF1_RS16750 ENOG41082BM Transcriptional regulator, arsr family BABF1_RS16755 ENOG4105CIS alcohol dehydrogenase BABF1_RS16790 ENOG4105C09 Bile acid BABF1_RS16795 ENOG4105CQB FAD linked oxidase domain protein BABF1_RS16815 ENOG4108UT6 Transferase hexapeptide repeat containing protein BABF1_RS16825 ENOG4105K64 Glycosyl transferase, family 2 BABF1_RS16830 ENOG4105E39 Enoyl-CoA hydratase BABF1_RS16840 ENOG4105KT7 mgtC SapB transporter BABF1_RS16855 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BABF1_RS16860 ENOG41073R8 VanW family BABF1_RS16870 ENOG4108R1P BABF1_RS16890 ENOG4105VEQ Cold shock protein BABF1_RS16910 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BABF1_RS16930 ENOG410904N short-chain dehydrogenase reductase BABF1_RS16955 ENOG4108IA2 Sodium pantothenate symporter BABF1_RS16965 ENOG4105C26 Dehydrogenase BABF1_RS16970 ENOG4105CHR reductase BABF1_RS16980 ENOG4105EWU Squalene--hopene cyclase BABF1_RS16990 ENOG4105FR1 rard protein BABF1_RS16995 ENOG410696E Membrane BABF1_RS17010 ENOG4105D1F ATP-binding protein BABF1_RS17020 ENOG4108ZAF Molybdopterin BABF1_RS17025 ENOG4105CVM Molybdenum cofactor synthesis domain protein BABF1_RS17030 ENOG4105D06 uba thif-type nad fad binding protein BABF1_RS17035 ENOG4105TMB Formate nitrite transporter BABF1_RS17045 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BABF1_RS17050 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BABF1_RS17060 ENOG4108JB9 formate dehydrogenase BABF1_RS17065 ENOG4105E1K spore germination protein BABF1_RS17120 ENOG4107QJT sodium dicarboxylate symporter BABF1_RS17125 ENOG4108KGH TRANSCRIPTIONal BABF1_RS17135 ENOG4105EMN RNA polymerase sigma factor BABF1_RS17150 ENOG4105CIG ABC transporter BABF1_RS17160 ENOG4105D9R oxidoreductase BABF1_RS17170 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BABF1_RS17175 ENOG4105K4P CoA-binding domain protein BABF1_RS17180 ENOG4105C0H protease BABF1_RS17185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BABF1_RS17195 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BABF1_RS17200 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BABF1_RS17205 ENOG4105W8X HesB YadR YfhF-family protein BABF1_RS17235 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BABF1_RS17240 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BABF1_RS17250 ENOG4108JJA ABC, transporter BABF1_RS17255 ENOG4108I0Z Aconitate hydratase BABF1_RS17295 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BABF1_RS17315 ENOG4107F3J Amp-dependent synthetase and ligase BABF1_RS17320 ENOG4107ZYJ bioY protein BABF1_RS17325 ENOG4105CEY Amp-dependent synthetase and ligase BABF1_RS17375 ENOG4107AYK membrAne BABF1_RS17385 ENOG4105BZU Histidine kinase BABF1_RS17390 ENOG4105FBA Phospholipase Carboxylesterase BABF1_RS17395 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BABF1_RS17400 ENOG4105CK7 Sodium proline symporter BABF1_RS17405 ENOG4105CBC glutamate synthase BABF1_RS17410 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BABF1_RS17415 ENOG4108VJ1 Transcriptional regulator (CarD family BABF1_RS17420 ENOG4108903 Formimidoylglutamase BABF1_RS17445 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BABF1_RS17505 ENOG4107QIV Cytochrome c biogenesis protein BABF1_RS17515 ENOG4107RSM transcriptional regulator BABF1_RS17520 ENOG4105VAW lrga family BABF1_RS17525 ENOG41067MG lrgb family BABF1_RS17550 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BABF1_RS17565 ENOG4105BZ1 (ABC) transporter BABF1_RS17570 ENOG4105BZ1 (ABC) transporter BABF1_RS17590 ENOG4105D7V transposase BABF1_RS17605 ENOG4105D5T phosphonate abc transporter BABF1_RS17625 ENOG4108SVB resolvase BABF1_RS17645 ENOG4105K7K Transcriptional regulator BABF1_RS17675 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BABF1_RS17680 ENOG4105XSJ toxin secretion phage lysis holin BABF1_RS17860 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BABF1_RS17960 ENOG4105C5F glutamine synthetase BABF1_RS17965 ENOG4105KV4 Transcriptional regulator BABF1_RS17970 ENOG4105CXI aluminum resistance protein BABF1_RS17975 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BABF1_RS17980 ENOG4105EN6 Membrane BABF1_RS17985 ENOG4106F1P AAA ATPase, central domain protein BABF1_RS18015 ENOG41069ER domain protein BABF1_RS18020 ENOG4105DM4 PTS System BABF1_RS18025 ENOG4105DE4 1-phosphofructokinase BABF1_RS18030 ENOG4105E98 transcriptional regulator DeoR family BABF1_RS18040 ENOG4108SJC Membrane BABF1_RS18050 ENOG4105C85 amino acid BABF1_RS18065 ENOG4105TMB Formate nitrite transporter BABF1_RS18070 ENOG4105K70 DNA-binding protein BABF1_RS18075 ENOG4105C59 p-type ATPase BABF1_RS18080 ENOG410681U heavy metal transport detoxification protein BABF1_RS18085 ENOG4105VPX protein, conserved in bacteria BABF1_RS18095 ENOG4105NIV Esterase BABF1_RS18100 ENOG4105E0A ABC, transporter BABF1_RS18130 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BABF1_RS18135 ENOG4105D03 DNA-3-methyladenine glycosylase II BABF1_RS18165 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BABF1_RS18170 ENOG4105BZU Histidine kinase BABF1_RS18185 ENOG41067MG lrgb family BABF1_RS18200 ENOG4107TTQ Alpha beta hydrolase fold BABF1_RS18205 ENOG4107YEI lmbE family BABF1_RS18230 ENOG4105F0V Cell wall hydrolase BABF1_RS18235 ENOG4107R6R udp-galactopyranose mutase BABF1_RS18240 ENOG4105E0M Sulfatase BABF1_RS18245 ENOG410890F Dynamin family BABF1_RS18255 ENOG4107QHE Choloylglycine hydrolase BABF1_RS18280 ENOG4105DA5 (ABC) transporter BABF1_RS18305 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BABF1_RS18310 ENOG4105DQU oxidoreductase, subunit beta BABF1_RS18315 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BABF1_RS18320 ENOG4108IGT Dipeptidase BABF1_RS18325 ENOG4105MCT stage V sporulation protein S BABF1_RS18330 ENOG4105D48 metallophosphoesterase BABF1_RS18355 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BABF1_RS18370 ENOG4105XZV Protein of unknown function (DUF3243) BABF1_RS18375 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BABF1_RS18400 ENOG4108JQ9 ABC transporter BABF1_RS18405 ENOG4105DIH basic membrane BABF1_RS18410 ENOG4105FDP GntR family transcriptional regulator BABF1_RS18415 ENOG4107QZI cell division protein FtsK BABF1_RS18425 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BABF1_RS18435 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BABF1_RS18445 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BABF1_RS18450 ENOG4108S0H Dipicolinic acid synthetase, b subunit BABF1_RS18455 ENOG4105E35 Dipicolinate synthase subunit A BABF1_RS18465 ENOG4105C1V Peptidase, M16 BABF1_RS18485 ENOG4105DTN riboflavin biosynthesis protein ribF BABF1_RS18490 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BABF1_RS18500 ENOG4105W7A Protein of unknown function (DUF503) BABF1_RS18510 ENOG4105VHM ribosomal protein BABF1_RS18515 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BABF1_RS18520 ENOG4105CHV Transcription elongation factor NusA BABF1_RS18530 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BABF1_RS18540 ENOG4105DZP Membrane-associated zinc metalloprotease BABF1_RS18545 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BABF1_RS18550 ENOG4105KNE Phosphatidate cytidylyltransferase BABF1_RS18595 ENOG4108HE4 integrase family BABF1_RS18605 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BABF1_RS18615 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BABF1_RS18630 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BABF1_RS18655 ENOG4105VB6 UPF0109 protein BABF1_RS18675 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BABF1_RS18680 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BABF1_RS18695 ENOG4105CHR reductase BABF1_RS18700 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BABF1_RS18715 ENOG4105CB5 ATP-dependent DNA helicase recG BABF1_RS18720 ENOG4105DP4 dak2 domain fusion protein ylov BABF1_RS18725 ENOG4108ZAA Alkaline-shock protein BABF1_RS18740 ENOG4105FJ0 thiamine BABF1_RS18745 ENOG4105DJV ribulose-phosphate 3-epimerase BABF1_RS18750 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BABF1_RS18755 ENOG4105D9P serine threonine protein kinase BABF1_RS18760 ENOG4108ZF3 Phosphatase BABF1_RS18770 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BABF1_RS18780 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BABF1_RS18785 ENOG4105C25 Primosomal protein n' BABF1_RS18790 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BABF1_RS18810 ENOG4105DSJ YicC domain protein BABF1_RS18820 ENOG4105F23 Fibronectin-binding protein BABF1_RS18825 ENOG4105DC7 peptidase M24 BABF1_RS18880 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BABF1_RS18905 ENOG4105C34 Pseudouridine synthase BABF1_RS18920 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BABF1_RS18930 ENOG4105DBK s4 domain protein BABF1_RS18935 ENOG41067XK integral membrane protein BABF1_RS18945 ENOG4105DFA alanine racemase domain protein BABF1_RS18950 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BABF1_RS18955 ENOG4105WR5 sporulation protein, YlmC YmxH family BABF1_RS18965 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BABF1_RS18975 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BABF1_RS18980 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BABF1_RS18985 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BABF1_RS18990 ENOG4105D4A Cell wall formation (By similarity) BABF1_RS18995 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BABF1_RS19000 ENOG4105CNI cell division protein FtsW BABF1_RS19015 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BABF1_RS19020 ENOG4105CJN penicillin-binding protein BABF1_RS19025 ENOG4105CJN penicillin-binding protein BABF1_RS19030 ENOG41068DC Essential cell division protein (By similarity) BABF1_RS19065 ENOG4105KNH Nucleic acid-binding protein BABF1_RS19115 ENOG4105XSJ toxin secretion phage lysis holin BABF1_RS19195 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BABF1_RS19205 ENOG4105CAR Terminase, large subunit BABF1_RS19290 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BABF1_RS19305 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BABF1_RS19350 ENOG4108IMY Transcriptional regulator BABF1_RS19370 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BABF1_RS19380 ENOG41063PX domain protein BABF1_RS19385 ENOG4105D78 K07001 NTE family protein BABF1_RS19390 ENOG4105H20 Sporulation integral membrane protein YlbJ BABF1_RS19400 ENOG4106H78 methyltransferase BABF1_RS19425 ENOG4107TB6 phosphoglycerate mutase BABF1_RS19440 ENOG4106UY4 Inherit from COG: Scp-like extracellular BABF1_RS19490 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BABF1_RS19495 ENOG4105CNI cell division protein FtsW BABF1_RS19510 ENOG4108IAB Phoh family BABF1_RS19530 ENOG4105QA2 BABF1_RS19535 ENOG4105CI3 gtp-binding protein typa BABF1_RS19545 ENOG4105ECY inositol monophosphatase BABF1_RS19565 ENOG4105CXN decarboxylase BABF1_RS19615 ENOG4105CPP Dehydrogenase, E1 component BABF1_RS19630 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BABF1_RS19645 ENOG4105CN5 Metallo-Beta-Lactamase BABF1_RS19650 ENOG4107ZYR domain protein BABF1_RS19685 ENOG4108XRC Protein of unknown function (DUF458) BABF1_RS19690 ENOG4107IN1 Protein of unknown function (DUF1797) BABF1_RS19705 ENOG4105EPM Diguanylate phosphodiesterase BABF1_RS19710 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BABF1_RS19735 ENOG4105UIN BABF1_RS19790 ENOG4108HGU Histidine kinase BABF1_RS19800 ENOG4105CHM Aminotransferase BABF1_RS19805 ENOG4105FKQ transcriptional regulator BABF1_RS19810 ENOG4105EG2 ABC transporter, permease BABF1_RS19820 ENOG4107FKK extracellular solute-binding protein family 1 BABF1_RS19830 ENOG4105CG3 alpha amylase, catalytic region BABF1_RS19875 ENOG4105CHU acetyl-coa acetyltransferase BABF1_RS19915 ENOG4105K7K Transcriptional regulator BABF1_RS19920 ENOG4105DTD Dehydrogenase BABF1_RS19930 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BABF1_RS19940 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BABF1_RS19965 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BABF1_RS19985 ENOG4106TD9 Diguanylate cyclase BABF1_RS20005 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BABF1_RS20020 ENOG4105CID antiterminator BABF1_RS20030 ENOG4105FDP GntR family transcriptional regulator BABF1_RS20040 ENOG4105CE4 GlcNAc 6-P deacetylase BABF1_RS20075 ENOG4107ZE5 PPIases accelerate the folding of proteins BABF1_RS20080 ENOG4105PTM secreted protein BABF1_RS20085 ENOG4105J7I hydrolase BABF1_RS20095 ENOG4105G6R Stage v sporulation protein ae BABF1_RS20105 ENOG4105CZ3 stage V sporulation protein ad BABF1_RS20110 ENOG41090VF Stage v sporulation protein ac BABF1_RS20130 ENOG4105C8J )-transporter BABF1_RS20135 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BABF1_RS20145 ENOG41082AN stage II sporulation protein BABF1_RS20150 ENOG4105DZ1 carboxypeptidase BABF1_RS20155 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BABF1_RS20160 ENOG4105DVE abc transporter atp-binding protein BABF1_RS20190 ENOG4105D7N magnesium and cobalt transport protein CorA BABF1_RS20215 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BABF1_RS20225 ENOG4105I3K Ferric uptake regulator, Fur family BABF1_RS20230 ENOG4105MZ9 stage II sporulation protein m BABF1_RS20250 ENOG4105CPC Aldo Keto reductase BABF1_RS20260 ENOG4105RHY Pfam:UPF0157 BABF1_RS20280 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BABF1_RS20290 ENOG4105ETE Transcriptional regulator (LacI family BABF1_RS20295 ENOG4108YM7 Gcn5-related n-acetyltransferase BABF1_RS20315 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BABF1_RS20320 ENOG4108R6K riboflavin synthase, subunit alpha BABF1_RS20340 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BABF1_RS20345 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BABF1_RS20350 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BABF1_RS20355 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BABF1_RS20365 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BABF1_RS20375 ENOG4105DFD Na H antiporter BABF1_RS20380 ENOG4105CGH 5'-nucleotidase BABF1_RS20420 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BABF1_RS20435 ENOG4108IXY short-chain dehydrogenase reductase BABF1_RS20440 ENOG41069FQ Metallo-beta-lactamase superfamily BABF1_RS20445 ENOG4105II7 pyrroline-5-carboxylate reductase BABF1_RS20450 ENOG4105EJQ L-serine dehydratase BABF1_RS20470 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BABF1_RS20480 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BABF1_RS20485 ENOG4105D9U N-acetyltransferase BABF1_RS20500 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BABF1_RS20505 ENOG4108QEG Membrane BABF1_RS20510 ENOG4105CDA abc transporter atp-binding protein BABF1_RS20515 ENOG4105E5Q amino acid AbC transporter BABF1_RS20520 ENOG4108HW3 (ABC) transporter BABF1_RS20530 ENOG4105G7B Protein of unknown function (DUF2992) BABF1_RS20535 ENOG4105E09 nadh pyrophosphatase BABF1_RS20545 ENOG4105C7S Dehydrogenase BABF1_RS20550 ENOG4105CPP Dehydrogenase, E1 component BABF1_RS20570 ENOG4107RDP Dehydrogenase BABF1_RS20580 ENOG4108JUB Transcriptional regulator BABF1_RS20590 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BABF1_RS20605 ENOG4107QQR Sporulation BABF1_RS20610 ENOG4105S1Z Stage IV sporulation protein B BABF1_RS20615 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BABF1_RS20625 ENOG4105DX0 Hemolysin A BABF1_RS20635 ENOG4105CTB Polyprenyl synthetase BABF1_RS20660 ENOG4108ZSR alkaline shock protein BABF1_RS20665 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BABF1_RS20690 ENOG410644B Stage III sporulation protein af BABF1_RS20700 ENOG4105KQ4 Stage iii sporulation protein ad BABF1_RS20705 ENOG4108CQH stage III sporulation protein AC BABF1_RS20710 ENOG4105KR5 Stage iii sporulation protein BABF1_RS20715 ENOG4105CD2 stage iii sporulation protein aa BABF1_RS20740 ENOG4105DC7 peptidase M24 BABF1_RS20755 ENOG4105CBJ Metal-dependent enzyme BABF1_RS20765 ENOG4107YBY Hydrolase BABF1_RS20785 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BABF1_RS20790 ENOG4105WZW rhodanese family BABF1_RS20810 ENOG41080TC multidrug resistance protein BABF1_RS20845 ENOG4105CJ1 ABC, transporter BABF1_RS20850 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BABF1_RS20880 ENOG4105C0D helicase BABF1_RS21000 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BABF1_RS21015 ENOG4105C28 cystathionine BABF1_RS21020 ENOG4105C28 cystathionine BABF1_RS21040 ENOG4105C5X domain protein BABF1_RS21050 ENOG4105DKQ ROK family BABF1_RS21060 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BABF1_RS21075 ENOG4108UTW Plays a role in the regulation of phosphate uptake BABF1_RS21080 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BABF1_RS21085 ENOG4105E2Z phosphate ABC transporter (Permease BABF1_RS21090 ENOG4105C8U phosphate abc transporter BABF1_RS21095 ENOG4105PWN phosphate abc transporter BABF1_RS21100 ENOG4107RF6 penicillin-binding protein BABF1_RS21110 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BABF1_RS21135 ENOG4105N80 Ferric uptake regulator, Fur family BABF1_RS21145 ENOG4105FDK ABC transporter BABF1_RS21150 ENOG4108JYZ YitT family BABF1_RS21155 ENOG41069ZM Protein of unknown function (DUF2624) BABF1_RS21180 ENOG4105EGD dinuclear metal center protein, YbgI family BABF1_RS21195 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BABF1_RS21200 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BABF1_RS21230 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BABF1_RS21235 ENOG4105KG3 cytidine deaminase BABF1_RS21240 ENOG4107YR5 Diacylglycerol kinase BABF1_RS21250 ENOG4105CTJ Metal Dependent Phosphohydrolase BABF1_RS21255 ENOG4105C9A Phoh family BABF1_RS21265 ENOG41068P3 sporulation protein YqfC BABF1_RS21270 ENOG4105KTH gatB Yqey BABF1_RS21280 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BABF1_RS21285 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BABF1_RS21305 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BABF1_RS21315 ENOG4105CSA Coproporphyrinogen iii oxidase BABF1_RS21320 ENOG4105KVH Transcriptional regulator BABF1_RS21345 ENOG4105TQK DNA polymerase iii, delta' subunit BABF1_RS21355 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BABF1_RS21360 ENOG4108UK2 deaminase BABF1_RS21365 ENOG4105KQC Competence protein BABF1_RS21375 ENOG4105DXX methyltransferase BABF1_RS21385 ENOG4108WF2 Metal Dependent Phosphohydrolase BABF1_RS21395 ENOG410812S Rna-binding protein BABF1_RS21405 ENOG4105CQW ribosome biogenesis GTPase YqeH BABF1_RS21410 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BABF1_RS21425 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BABF1_RS21445 ENOG4108TVJ Nitroreductase BABF1_RS21460 ENOG4105G6Z alkaline phosphatase BABF1_RS21470 ENOG4108MUZ hydrolase BABF1_RS21505 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BABF1_RS21510 ENOG4105MIR Phenylalanine 4-monooxygenase BABF1_RS21520 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BABF1_RS21560 ENOG4105S6R Iron-hydroxamate transporter permease subunit BABF1_RS21565 ENOG4108V5C ABC transporter BABF1_RS21575 ENOG4108EKI Dehydrogenase BABF1_RS21580 ENOG4105C28 cystathionine BABF1_RS21610 ENOG4107XRG penicillin-binding protein BABF1_RS21625 ENOG4105CFP Peptidase U32 BABF1_RS21630 ENOG4105XYU peptidase (U32 family) BABF1_RS21635 ENOG4108VQJ O-methyltransferase BABF1_RS21640 ENOG4105HHA aminodeoxychorismate lyase BABF1_RS21660 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BABF1_RS21670 ENOG4105C02 permease BABF1_RS21685 ENOG41060CR BABF1_RS21690 ENOG4105C7H Helicase, RecD TraA family BABF1_RS21700 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BABF1_RS21705 ENOG4105C3J Cysteine desulfurase BABF1_RS21715 ENOG4105D1H recombination factor protein RarA BABF1_RS21720 ENOG4108VCI transcription factor, rsfa family BABF1_RS21725 ENOG4105CUZ uba thif-type nad fad binding protein BABF1_RS21735 ENOG4105CUT histidyl-tRNA synthetase BABF1_RS21745 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BABF1_RS21755 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BABF1_RS21760 ENOG41076HS cation diffusion facilitator family transporter BABF1_RS21765 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BABF1_RS21775 ENOG4105CKP Polysaccharide Biosynthesis Protein BABF1_RS21780 ENOG4108QG2 Membrane BABF1_RS21790 ENOG4105VIE preprotein translocase, subunit YajC BABF1_RS21805 ENOG41061AI Protein of unknown function (DUF2905) BABF1_RS21820 ENOG4108HUF Transporter BABF1_RS21830 ENOG4108IPJ Membrane BABF1_RS21835 ENOG4108IPJ Membrane BABF1_RS21840 ENOG41082BM Transcriptional regulator, arsr family BABF1_RS21865 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BABF1_RS21870 ENOG4108IYU L-aspartate oxidase BABF1_RS21885 ENOG4108RPX mosc domain containing protein BABF1_RS21890 ENOG4105CQC Prephenate dehydratase BABF1_RS21920 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BABF1_RS21935 ENOG4105X36 (ribosomal) protein BABF1_RS21945 ENOG4105C03 ribonuclease BABF1_RS21960 ENOG4107QMS site-determining protein BABF1_RS21975 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BABF1_RS21980 ENOG4105DFF Rod shape-determining protein mreb BABF1_RS22000 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BABF1_RS22005 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BABF1_RS22015 ENOG41068KH stage VI sporulation protein D BABF1_RS22025 ENOG4105D52 delta-aminolevulinic acid dehydratase BABF1_RS22050 ENOG4105K56 Transcriptional regulator BABF1_RS22070 ENOG4108IUQ atp-dependent protease BABF1_RS22095 ENOG4108QCI YvbH-like oligomerisation region BABF1_RS22115 ENOG4105M59 Phosphodiesterase, mj0936 family BABF1_RS22120 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BABF1_RS22130 ENOG4108XJQ germination protein BABF1_RS22140 ENOG4108PCX Major Facilitator BABF1_RS22150 ENOG4105KBX Transcriptional regulator, TetR family BABF1_RS22165 ENOG4105PFC Transcriptional regulator BABF1_RS22180 ENOG4105DZC cytosine deaminase BABF1_RS22185 ENOG4105DZC cytosine deaminase BABF1_RS22190 ENOG4105DEF Extracellular solute-binding protein, family 5 BABF1_RS22195 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BABF1_RS22210 ENOG4108JQ7 (ABC) transporter BABF1_RS22220 ENOG4105DY9 regulatoR BABF1_RS22235 ENOG41067S9 phage shock protein C, PspC BABF1_RS22240 ENOG4108JCI Transcriptional regulator BABF1_RS22250 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BABF1_RS22255 ENOG4108Z40 Transcriptional regulator BABF1_RS22260 ENOG4105RHA ABC transporter, permease BABF1_RS22265 ENOG4108IUX (ABC) transporter BABF1_RS22270 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BABF1_RS22280 ENOG4105E14 MotA TolQ exbB proton channel BABF1_RS22285 ENOG4108VXD carboxy-peptidase BABF1_RS22295 ENOG4105E33 succinate dehydrogenase BABF1_RS22305 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BABF1_RS22320 ENOG4105K63 Thioredoxin BABF1_RS22325 ENOG4105C10 Electron transfer flavoprotein BABF1_RS22330 ENOG4105BZJ Electron transfer flavoprotein BABF1_RS22335 ENOG41060WC Enoyl-CoA hydratase BABF1_RS22340 ENOG4107Z3H Transcriptional regulator, TetR family BABF1_RS22345 ENOG4105CEY Amp-dependent synthetase and ligase BABF1_RS22355 ENOG4105J76 Periplasmic binding protein BABF1_RS22360 ENOG4105S6R Iron-hydroxamate transporter permease subunit BABF1_RS22400 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BABF1_RS22410 ENOG4105DR4 Methyltransferase BABF1_RS22425 ENOG4105KFN sortase, SrtB family BABF1_RS22430 ENOG4105E0A ABC, transporter BABF1_RS22445 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BABF1_RS22455 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BABF1_RS22465 ENOG4105FE9 pseudouridine synthase BABF1_RS22475 ENOG4105DCG PHP domain protein BABF1_RS22510 ENOG4105C5S asparaginyl-tRNA synthetase BABF1_RS22515 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BABF1_RS22525 ENOG4108RWN rrna methyltransferase BABF1_RS22560 ENOG4105C0R drug resistance transporter emrb qaca subfamily BABF1_RS22565 ENOG4105CW7 secretion protein, HlyD family BABF1_RS22570 ENOG4108JGH Tetr family transcriptional regulator BABF1_RS22575 ENOG4105CN9 Peptidase m42 family protein BABF1_RS22595 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BABF1_RS22600 ENOG4105C22 threonyL-tRNA synthetase BABF1_RS22605 ENOG4108TDW sporulation protein YtxC BABF1_RS22625 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BABF1_RS22635 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BABF1_RS22640 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BABF1_RS22650 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BABF1_RS22655 ENOG4105C2M dna polymerase I BABF1_RS22660 ENOG4105BZU Histidine kinase BABF1_RS22665 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BABF1_RS22680 ENOG4108HMX isocitrate dehydrogenase (NADP) BABF1_RS22685 ENOG4105BZN citrate synthase BABF1_RS22695 ENOG4108REF Sporulation integral membrane protein ytvi BABF1_RS22700 ENOG4105FS0 cytoplasmic membrane protein BABF1_RS22725 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BABF1_RS22730 ENOG4105C6K Malic enzyme BABF1_RS22735 ENOG4105C0B DNA polymerase III (alpha subunit) BABF1_RS22740 ENOG4105VV2 BABF1_RS22750 ENOG4105SFS phosphoesterase RecJ domain protein BABF1_RS22780 ENOG4105DC7 peptidase M24 BABF1_RS22815 ENOG4105Z7P Acetyltransferase (GNAT) family BABF1_RS22820 ENOG41082W1 Cupin 2, conserved barrel domain protein BABF1_RS22830 ENOG4105VZ8 Transcriptional regulator BABF1_RS22850 ENOG4107YZX Universal stress protein BABF1_RS22890 ENOG4108JYZ YitT family BABF1_RS22910 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BABF1_RS22920 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BABF1_RS22925 ENOG4105KBJ sporulation protein ytfj BABF1_RS22940 ENOG4105EFZ amidohydrolase BABF1_RS22950 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BABF1_RS22975 ENOG4106KR7 LysR family Transcriptional regulator BABF1_RS22995 ENOG4105C28 cystathionine BABF1_RS23015 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BABF1_RS23025 ENOG4105EMN RNA polymerase sigma factor BABF1_RS23045 ENOG4105F1V Acetoin utilization protein BABF1_RS23050 ENOG4105W87 Cbs domain BABF1_RS23055 ENOG4105DGU Histone deacetylase BABF1_RS23065 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BABF1_RS23075 ENOG4107SNB ankyrin repeat protein YahD BABF1_RS23080 ENOG4105EP9 oxidoreductase BABF1_RS23110 ENOG4105ETE Transcriptional regulator (LacI family BABF1_RS23130 ENOG4105C88 aminopeptidase BABF1_RS23175 ENOG4108VDD TRNA binding domain protein BABF1_RS23205 ENOG4105C8F Beta-lactamase domain protein BABF1_RS23220 ENOG4108V15 phosphotransferase enzyme family BABF1_RS23225 ENOG4108IUM Glycogen debranching enzyme BABF1_RS23235 ENOG4107QSE Dipeptidase BABF1_RS23240 ENOG4105YW5 deoR family transcriptional regulator BABF1_RS23255 ENOG4105CBX hi0933 family BABF1_RS23290 ENOG4108VJ1 Transcriptional regulator (CarD family BABF1_RS23295 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BABF1_RS23300 ENOG4105CSC Glucose uptake protein BABF1_RS23315 ENOG4108ZAF Molybdopterin BABF1_RS23320 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BABF1_RS23325 ENOG4105CVM Molybdenum cofactor synthesis domain protein BABF1_RS23335 ENOG4105D06 uba thif-type nad fad binding protein BABF1_RS23340 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BABF1_RS23360 ENOG41085GJ domain protein BABF1_RS23370 ENOG4105DWV Homoserine O-trans-acetylase BABF1_RS23380 ENOG4108B31 Spore germination protein BABF1_RS23410 ENOG410605W Major Facilitator BABF1_RS23415 ENOG4107S91 Sodium hydrogen exchanger BABF1_RS23420 ENOG4105NCW Trka-c domain protein BABF1_RS23435 ENOG4105C19 ABC transporter BABF1_RS23455 ENOG4105N5T Radical SAM Protein BABF1_RS23465 ENOG4105DA5 (ABC) transporter BABF1_RS23495 ENOG4105E8V Alpha Beta Hydrolase Fold protein BABF1_RS23500 ENOG4108Z0R Transferase BABF1_RS23505 ENOG4105YVM Phosphoesterase, PA-phosphatase related BABF1_RS23510 ENOG4105BZF Glycosyl transferase (Group 1 BABF1_RS23520 ENOG4108RIR Molybdenum cofactor biosynthesis protein BABF1_RS23570 ENOG4105EGD dinuclear metal center protein, YbgI family BABF1_RS23575 ENOG4105BZU Histidine kinase BABF1_RS23580 ENOG4105BZU Histidine kinase BABF1_RS23585 ENOG4107S9D Alpha beta hydrolase BABF1_RS23605 ENOG4105D2X ABC transporter substrate-binding protein BABF1_RS23615 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BABF1_RS23670 ENOG4108V2W Carbonate dehydratase BABF1_RS23675 ENOG4105C4M (Ubiquinol oxidase) subunit I BABF1_RS23680 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BABF1_RS23725 ENOG41087YS Phage shock protein A BABF1_RS23760 ENOG4105BZU Histidine kinase BABF1_RS23765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BABF1_RS23790 ENOG4108UGV hypoxanthine phosphoribosyltransferase BABF1_RS23795 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BABF1_RS23830 ENOG4107ZTW SNARE associated Golgi BABF1_RS23845 ENOG4105C19 ABC transporter BABF1_RS23850 ENOG41086D8 Transcriptional regulator BABF1_RS23890 ENOG4105C6Z Gluconate BABF1_RS23895 ENOG4105FDP GntR family transcriptional regulator BABF1_RS23915 ENOG41069H0 dihydroorotase EC 3.5.2.3 BABF1_RS23945 ENOG4105DTQ mandelate racemase muconate lactonizing BABF1_RS23955 ENOG4108IPT Naphthoate synthase BABF1_RS23960 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BABF1_RS23965 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BABF1_RS23970 ENOG4105E4F Isochorismate synthase BABF1_RS23975 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BABF1_RS23985 ENOG4105VEQ Cold shock protein BABF1_RS24005 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BABF1_RS24015 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BABF1_RS24035 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BABF1_RS24130 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BABF1_RS24165 ENOG4105KT7 mgtC SapB transporter BABF1_RS24170 ENOG4107PBV potassium channel BABF1_RS24180 ENOG4107QYV phosphohexose isomerase BABF1_RS24185 ENOG4105WG9 Conserved Protein BABF1_RS24195 ENOG4105CHM Aminotransferase BABF1_RS24200 ENOG4108ZB6 transcriptional regulator AsnC family BABF1_RS24205 ENOG4105C5I Dehydrogenase BABF1_RS24210 ENOG4108MUZ hydrolase BABF1_RS24220 ENOG4105C87 Aminotransferase class I and II BABF1_RS24230 ENOG4105Y38 Kinase-associated protein B BABF1_RS24240 ENOG4107R3E Citrate transporter BABF1_RS24255 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BABF1_RS24260 ENOG4105KA0 thioesterase Superfamily protein BABF1_RS24280 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BABF1_RS24300 ENOG41069ER domain protein BABF1_RS24315 ENOG4105CEP NADH dehydrogenase BABF1_RS24345 ENOG4105EWC Purine nucleoside phosphorylase BABF1_RS24365 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BABF1_RS24390 ENOG4108JJA ABC, transporter BABF1_RS24395 ENOG4105C4B ABC transporter, permease BABF1_RS24400 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BABF1_RS24445 ENOG41083MR nifu domain-containing protein BABF1_RS24460 ENOG4108W5N phosphatidylglycerophosphatase a BABF1_RS24470 ENOG4105DYS nad(p)h dehydrogenase (quinone) BABF1_RS24475 ENOG4105D4U had-superfamily hydrolase, subfamily iia BABF1_RS24490 ENOG4105CBT Fructose-1,6-bisphosphatase BABF1_RS24505 ENOG4105MMD transcriptional regulator BABF1_RS24510 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BABF1_RS24515 ENOG4107TXC Transcriptional regulator BABF1_RS24520 ENOG41090T1 Membrane BABF1_RS24545 ENOG4105FAA peptidase M23 BABF1_RS24555 ENOG4105KZD Domain of unknown function (DUF1805) BABF1_RS24560 ENOG4107R8B 5'-nucleotidase BABF1_RS24580 ENOG4105DIW FeS assembly protein SUFB BABF1_RS24585 ENOG4108UNV SUF system FeS assembly protein, NifU family BABF1_RS24590 ENOG4105C9B Cysteine desulfurase BABF1_RS24595 ENOG4105JRK feS assembly protein SufD BABF1_RS24600 ENOG4105C3K feS assembly ATPase SufC BABF1_RS24605 ENOG4105D01 (LipO)protein BABF1_RS24610 ENOG4105D01 (LipO)protein BABF1_RS24615 ENOG4108UMI ABC transporter, permease BABF1_RS24650 ENOG41080E8 Transcriptional regulator, Spx MgsR family BABF1_RS24695 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BABF1_RS24720 ENOG4108W8B Beta-lactamase domain protein BABF1_RS24725 ENOG4105C1G acyl-Coa dehydrogenase BABF1_RS24730 ENOG4105CHU acetyl-coa acetyltransferase BABF1_RS24745 ENOG4105DZ1 carboxypeptidase BABF1_RS24765 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BABF1_RS24780 ENOG4108SUT Major Facilitator Superfamily BABF1_RS24785 ENOG4107R7I amino acid BABF1_RS24795 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BABF1_RS24805 ENOG4107AYK membrAne BABF1_RS24840 ENOG4107ZTW SNARE associated Golgi BABF1_RS24850 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BABF1_RS24855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BABF1_RS24860 ENOG4105BZU Histidine kinase BABF1_RS24870 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BABF1_RS24885 ENOG4105VG1 fes assembly suf system protein BABF1_RS24890 ENOG4105D4Y metalloprotease BABF1_RS24910 ENOG4107S91 Sodium hydrogen exchanger BABF1_RS24915 ENOG4105NCW Trka-c domain protein BABF1_RS24925 ENOG4108RMU ferritin dps family protein BABF1_RS24940 ENOG4108URH decarboxylase BABF1_RS24960 ENOG4105D9N nucleoside BABF1_RS24965 ENOG4105D9N nucleoside BABF1_RS24980 ENOG4108RYK Nad-dependent epimerase dehydratase BABF1_RS24995 ENOG4105CV8 reductase BABF1_RS25000 ENOG4105F27 Major Facilitator BABF1_RS25005 ENOG4105KVH Transcriptional regulator BABF1_RS25020 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BABF1_RS25025 ENOG4105D4A Cell wall formation (By similarity) BABF1_RS25035 ENOG4105C8Q Methyl-accepting chemotaxis BABF1_RS25045 ENOG4105WMR Protein CrcB homolog BABF1_RS25050 ENOG4105WMR Protein CrcB homolog BABF1_RS25065 ENOG4108MK9 spermidine N(1)-acetyltransferase BABF1_RS25070 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BABF1_RS25085 ENOG4108IPW abc transporter atp-binding protein BABF1_RS25090 ENOG4105CM4 permease protein BABF1_RS25120 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BABF1_RS25130 ENOG4105XZU Preprotein translocase, subunit SecG BABF1_RS25135 ENOG41067MG lrgb family BABF1_RS25235 ENOG4105EFC phage portal protein HK97 family BABF1_RS25255 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BABF1_RS25265 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BABF1_RS25270 ENOG4105CP7 Triose-phosphate isomerase BABF1_RS25295 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BABF1_RS25315 ENOG41090VF Stage v sporulation protein ac BABF1_RS25320 ENOG4105CZ3 stage V sporulation protein ad BABF1_RS25335 ENOG4105H67 Protein of unknown function (DUF421) BABF1_RS25340 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BABF1_RS25345 ENOG4105KRI phosphocarrier protein (HPr BABF1_RS25355 ENOG4105CHW UPF0052 protein BABF1_RS25365 ENOG4108Z4K mutator MutT protein BABF1_RS25375 ENOG4105C3M thioredoxin reductase BABF1_RS25385 ENOG4108S4C acetyltransferase BABF1_RS25405 ENOG41086DT Membrane protein of unknown function BABF1_RS25415 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BABF1_RS25420 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BABF1_RS25425 ENOG4105D7V transposase BABF1_RS25440 ENOG4107TXC Transcriptional regulator BABF1_RS25465 ENOG4105HMI Membrane BABF1_RS25470 ENOG4105DUM transcriptional regulator, lysR family BABF1_RS25480 ENOG4108WS4 fmn reductase BABF1_RS25495 ENOG4105BZ1 (ABC) transporter BABF1_RS25505 ENOG4105CN1 protease BABF1_RS25510 ENOG4105CRP Part of the ABC transporter FtsEX involved in BABF1_RS25515 ENOG4105CAK Cell division ATP-binding protein ftsE BABF1_RS25530 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BABF1_RS25535 ENOG4105MS2 ribosomal subunit Interface protein BABF1_RS25540 ENOG4105VEQ Cold shock protein BABF1_RS25545 ENOG41081UC Inherit from COG: Competence protein BABF1_RS25560 ENOG4105KVH Transcriptional regulator BABF1_RS25570 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BABF1_RS25575 ENOG4108KGH TRANSCRIPTIONal BABF1_RS25580 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BABF1_RS25585 ENOG4105C6Y Udp-glucose 6-dehydrogenase BABF1_RS25590 ENOG4105ESV Glycosyl transferase, family 4 BABF1_RS25600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BABF1_RS25615 ENOG410901P UPF0249 protein BABF1_RS25620 ENOG4105F8D glycoside hydrolase family 4 BABF1_RS25625 ENOG4105VCP PTS System BABF1_RS25630 ENOG4105CK1 PTS System BABF1_RS25640 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BABF1_RS25645 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BABF1_RS25650 ENOG4105VCP PTS System BABF1_RS25660 ENOG4105VZJ PTS System BABF1_RS25675 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BABF1_RS25680 ENOG4105ECB domain protein BABF1_RS25685 ENOG4107RSM transcriptional regulator BABF1_RS25720 ENOG4105DAA L-lactate BABF1_RS25730 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BABF1_RS25740 ENOG4105E0M Sulfatase BABF1_RS25765 ENOG4107R8N Glycosyl transferase, family 2 BABF1_RS25770 ENOG4105C94 Transporter BABF1_RS25775 ENOG41069ER domain protein BABF1_RS25800 ENOG4105KBK Zinc finger, swim domain protein BABF1_RS25805 ENOG4105C0D helicase BABF1_RS25835 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BABF1_RS25845 ENOG4107RBB ABC transporter, permease BABF1_RS25850 ENOG4105C19 ABC transporter BABF1_RS25870 ENOG4105CXY transporter BABF1_RS25885 ENOG4105BZU Histidine kinase BABF1_RS25890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BABF1_RS25895 ENOG4105CMR udp-glucose 4-epimerase BABF1_RS25910 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BABF1_RS25915 ENOG4105EY8 ABC transporter BABF1_RS25965 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BABF1_RS25980 ENOG4105FRN stage II sporulation protein BABF1_RS26015 ENOG4106778 Protein of unknown function (DUF1146) BABF1_RS26020 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BABF1_RS26025 ENOG4105C8S subunit m BABF1_RS26030 ENOG4105D65 subunit l BABF1_RS26055 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BABF1_RS26060 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BABF1_RS26070 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BABF1_RS26075 ENOG4105BZU Histidine kinase BABF1_RS26125 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BABF1_RS26130 ENOG41062M3 atp synthase BABF1_RS26160 ENOG4108YZG isomerase BABF1_RS26175 ENOG4108VGI doxx family BABF1_RS26180 ENOG4107XC4 flavin reductase domain protein, FMN-binding BABF1_RS26195 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BABF1_RS26205 ENOG4108ZXQ stage ii sporulation protein r BABF1_RS26210 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BABF1_RS26215 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BABF1_RS26230 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BABF1_RS26235 ENOG4105CBT Fructose-1,6-bisphosphatase BABF1_RS26240 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BABF1_RS26275 ENOG4105C1G acyl-Coa dehydrogenase BABF1_RS26280 ENOG4105C1G acyl-Coa dehydrogenase BABF1_RS26285 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BABF1_RS26295 ENOG4105DF6 Fe-S oxidoreductase BABF1_RS26310 ENOG4105BZU Histidine kinase BABF1_RS26335 ENOG4105BZU Histidine kinase BABF1_RS26340 ENOG4105KCT ABC transporter BABF1_RS26345 ENOG4108M15 ABC transporter BABF1_RS26350 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BABF1_RS26360 ENOG4105IIU Aminopeptidase BABF1_RS26380 ENOG4105EMN RNA polymerase sigma factor BABF1_RS26390 ENOG410684U Domain of unknown function (DUF1934) BABF1_RS26410 ENOG4105CYW agmatinase BABF1_RS26420 ENOG4105DXB Major Facilitator superfamily BABF1_RS26425 ENOG4107SWG transcriptional regulator MERR family BABF1_RS26430 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BABF1_RS26435 ENOG4105BZ4 penicillin-binding protein BABF1_RS26440 ENOG4108XFG YwhD family BABF1_RS26445 ENOG4108Z4T Peptidase M50 BABF1_RS26450 ENOG41069HH 4-oxalocrotonate tautomerase BABF1_RS26455 ENOG4105DCI Phosphohydrolase BABF1_RS26460 ENOG4108MES Periplasmic binding protein BABF1_RS26465 ENOG4105E0A ABC, transporter BABF1_RS26470 ENOG4105EHG Permease protein BABF1_RS26475 ENOG4105DQ5 transport system permease protein BABF1_RS26485 ENOG4108VCI transcription factor, rsfa family BABF1_RS26500 ENOG4108IJ2 phosphate acetyltransferase BABF1_RS26515 ENOG4108VKI Cell wall hydrolase BABF1_RS26535 ENOG4107SVH Potassium channel protein BABF1_RS26545 ENOG410667J hydrolase BABF1_RS26550 ENOG4105VCH membrane BABF1_RS26560 ENOG4108TU7 Inherit from COG: (ABC) transporter BABF1_RS26565 ENOG4105CJ1 ABC, transporter BABF1_RS26570 ENOG41090WU lipolytic protein G-D-S-L family BABF1_RS26585 ENOG4105D6E homoserine dehydrogenase BABF1_RS26610 ENOG4108Y4K DNA-binding transcriptional activator BABF1_RS26620 ENOG4105WH1 Two component transcriptional regulator luxr family BABF1_RS26630 ENOG4105DWF phosphomethylpyrimidine kinase BABF1_RS26635 ENOG4105BZU Histidine kinase BABF1_RS26640 ENOG4105VCD cytoplasmic protein BABF1_RS26645 ENOG4105D22 carbon starvation protein BABF1_RS26650 ENOG4105DY9 regulatoR BABF1_RS26655 ENOG41079KZ Major Facilitator Superfamily BABF1_RS26675 ENOG4105EN6 Membrane BABF1_RS26680 ENOG4106YBV Methyl-accepting chemotaxis BABF1_RS26690 ENOG4108S4H thioesterase Superfamily protein BABF1_RS26700 ENOG4105JEU Glycosyl transferase, family 2 BABF1_RS26705 ENOG4105C5H ABC transporter BABF1_RS26725 ENOG4105CKK Glycosyl transferase, family 2 BABF1_RS26730 ENOG41067SE Tetr family transcriptional regulator BABF1_RS26740 ENOG4105E0X reductase BABF1_RS26745 ENOG4106F5Q Membrane BABF1_RS26760 ENOG4105DY9 regulatoR BABF1_RS26765 ENOG4108HRK Histidine kinase BABF1_RS26770 ENOG4107RGD Major Facilitator superfamily BABF1_RS26785 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BABF1_RS26795 ENOG4105IW1 AmiS UreI transporter BABF1_RS26805 ENOG4105CMR udp-glucose 4-epimerase BABF1_RS26810 ENOG4108UT2 hemolysin iii BABF1_RS26820 ENOG4105C1J atp-dependent rna helicase BABF1_RS26835 ENOG4105DPN Oligoendopeptidase f BABF1_RS26855 ENOG4105C0H protease BABF1_RS26860 ENOG4105Q2H domain protein BABF1_RS26875 ENOG4105BZU Histidine kinase BABF1_RS26880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BABF1_RS26910 ENOG4105CDU Replicative dna helicase BABF1_RS26920 ENOG4105BZR domain protein BABF1_RS26925 ENOG4108XMW Membrane BABF1_RS26935 ENOG4108UUM single-stranded DNA-binding protein BABF1_RS26945 ENOG4105C3G gtp-binding protein BABF1_RS26950 ENOG4105VDK protein, conserved in bacteria BABF1_RS26955 ENOG4105D8X mechanosensitive ion channel BABF1_RS26960 ENOG4108ZDA Sporulation protein YyaC BABF1_RS26965 ENOG4105FA0 parb-like partition protein BABF1_RS26970 ENOG4107QJE Chromosome Partitioning Protein BABF1_RS26990 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BABF1_RS27000 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BABF1_RS27065 ENOG4105EKQ RNA-directed DNA polymerase BABF1_RS27140 ENOG4105EKQ RNA-directed DNA polymerase BABF1_RS27230 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BABF1_RS27260 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BABF1_RS27270 ENOG4108MEK Metal-binding protein YodA BABF1_RS27295 ENOG4108IBT Inherit from COG: transposase BABF1_RS27320 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BABF1_RS27330 ENOG4105KRN Transcriptional regulator, abrb family BABF1_RS27430 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BABF1_RS27485 ENOG4105C6Y Udp-glucose 6-dehydrogenase BABF1_RS27490 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BABF1_RS27510 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BABF1_RS27515 ENOG4106AKK s-layer domain-containing protein BABF1_RS27535 ENOG4105DHF Membrane BABF1_RS27765 ENOG4105CNU cell division protein FtsK BABF1_RS27995 ENOG4107QJE Chromosome Partitioning Protein BABF1_RS28040 ENOG4105EWC Purine nucleoside phosphorylase BABF1_RS28115 ENOG4105C3F Signal peptidase i BABF1_RS28145 ENOG4105N14 lysine exporter protein LysE YggA BABF1_RS28180 ENOG4108J59 Extracellular solute-binding protein, family 5 BABF1_RS28190 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)