locus-tag class description AW20_RS00055 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AW20_RS00065 ENOG4108MEK Metal-binding protein YodA AW20_RS00095 ENOG4108IBT Inherit from COG: transposase AW20_RS00125 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW20_RS00300 ENOG4105C6Y Udp-glucose 6-dehydrogenase AW20_RS00305 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW20_RS00310 ENOG4108NV9 Glycosyl Transferase AW20_RS00325 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AW20_RS00330 ENOG4106AKK s-layer domain-containing protein AW20_RS00355 ENOG4105DHF Membrane AW20_RS00580 ENOG4105CNU cell division protein FtsK AW20_RS00695 ENOG4105EKQ RNA-directed DNA polymerase AW20_RS00775 ENOG4105EKQ RNA-directed DNA polymerase AW20_RS00845 ENOG4105BZG amino acid carrier protein AW20_RS00860 ENOG4108M1A Chitin-binding protein AW20_RS00915 ENOG4105C9U ATP-dependent DNA helicase RecQ AW20_RS00935 ENOG4105EEM helicase AW20_RS00985 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AW20_RS01030 ENOG4108M1A Chitin-binding protein AW20_RS01035 ENOG41082BV acetyltransferase AW20_RS01040 ENOG4105E66 phosphoriboisomerase A AW20_RS01065 ENOG4108IJ7 Glycine betaine AW20_RS01070 ENOG4107SQ8 Glycine betaine AW20_RS01105 ENOG4105RHY Pfam:UPF0157 AW20_RS01110 ENOG4105E1F short-chain dehydrogenase reductase AW20_RS01120 ENOG4107RUY (E1 component), alpha subunit AW20_RS01130 ENOG4107QKR Dehydrogenase AW20_RS01150 ENOG41062ES Transcriptional regulator AW20_RS01170 ENOG4105E98 transcriptional regulator DeoR family AW20_RS01190 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AW20_RS01220 ENOG4107Z3H Transcriptional regulator, TetR family AW20_RS01225 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AW20_RS01230 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AW20_RS01235 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AW20_RS01255 ENOG4105MSI germination protein ypeb AW20_RS01275 ENOG4108V3A UPF0421 protein AW20_RS01310 ENOG4105FDR Membrane AW20_RS01320 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AW20_RS01345 ENOG4108IUM Glycogen debranching enzyme AW20_RS01360 ENOG4105DY8 decarboxylase AW20_RS01380 ENOG4105PAD Hydrolase AW20_RS01405 ENOG4107VFR oxidoreductase AW20_RS01445 ENOG4105PKS Excinuclease abc c subunit domain protein AW20_RS01480 ENOG4105KWG Pfam:DUF1696 AW20_RS01515 ENOG4108XI2 Domain of unknown function (DUF1963) AW20_RS01550 ENOG4108Z4K mutator MutT protein AW20_RS01555 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AW20_RS01560 ENOG4105E09 nadh pyrophosphatase AW20_RS01575 ENOG4105FCD Major Facilitator AW20_RS01610 ENOG4107Y9U Membrane AW20_RS01630 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AW20_RS01645 ENOG4107Y80 Major Facilitator superfamily AW20_RS01675 ENOG4108V4B ThiJ pfpI AW20_RS01710 ENOG4105FQP Beta-lactamase AW20_RS01720 ENOG4105CJN penicillin-binding protein AW20_RS01725 ENOG4105CB2 alcohol dehydrogenase AW20_RS01740 ENOG4108HGU Histidine kinase AW20_RS01750 ENOG4108JJB ABC transporter AW20_RS01770 ENOG4107RF6 penicillin-binding protein AW20_RS01775 ENOG4105BZU Histidine kinase AW20_RS01785 ENOG410667J hydrolase AW20_RS01895 ENOG4105ETU transcriptional activator (TenA AW20_RS02010 ENOG4105CPQ Dehydrogenase AW20_RS02045 ENOG4105CUV Homoserine Kinase AW20_RS02065 ENOG4107Y80 Major Facilitator superfamily AW20_RS02075 ENOG4105FQP Beta-lactamase AW20_RS02090 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW20_RS02090 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW20_RS02130 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AW20_RS02140 ENOG4105T9C HD domain AW20_RS02175 ENOG4105DBI uridine monophosphokinase AW20_RS02180 ENOG4105WCN acetyltransferase AW20_RS02190 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AW20_RS02195 ENOG4107QX3 carboxylase AW20_RS02200 ENOG4105E39 Enoyl-CoA hydratase AW20_RS02205 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AW20_RS02210 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AW20_RS02215 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AW20_RS02220 ENOG4105C1G acyl-Coa dehydrogenase AW20_RS02235 ENOG4107Z3H Transcriptional regulator, TetR family AW20_RS02245 ENOG4105CJ1 ABC, transporter AW20_RS02260 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AW20_RS02265 ENOG4105CEP NADH dehydrogenase AW20_RS02270 ENOG4106ANW SMI1_KNR4 AW20_RS02280 ENOG4105BZU Histidine kinase AW20_RS02290 ENOG4105C5H ABC transporter AW20_RS02295 ENOG41067SE Tetr family transcriptional regulator AW20_RS02315 ENOG4108VXD carboxy-peptidase AW20_RS02330 ENOG4105VZ8 Transcriptional regulator AW20_RS02370 ENOG4105DH8 myo-inositol catabolism AW20_RS02375 ENOG4105D2N Aldolase AW20_RS02400 ENOG4105CK5 oxidoreductase AW20_RS02405 ENOG4105IE8 Alpha-ketoglutarate permease AW20_RS02410 ENOG4105ETE Transcriptional regulator (LacI family AW20_RS02415 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AW20_RS02430 ENOG4107RF6 penicillin-binding protein AW20_RS02455 ENOG4105CIN aminoacyl-histidine dipeptidase AW20_RS02495 ENOG41090HR transcriptional regulator AW20_RS02500 ENOG4107RA9 decarboxylase AW20_RS02505 ENOG4108I0C methyltransferase AW20_RS02515 ENOG41088CC tellurite resistance protein tehB AW20_RS02535 ENOG4108RZE Tetr family transcriptional regulator AW20_RS02550 ENOG4105C1J atp-dependent rna helicase AW20_RS02565 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AW20_RS02585 ENOG4107STF Involved in phosphonate degradation (By similarity) AW20_RS02595 ENOG4105RD7 BadF BadG BcrA BcrD AW20_RS02620 ENOG4105F32 YngK protein AW20_RS02645 ENOG4108KPJ rna polymerase sigma factor AW20_RS02650 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B AW20_RS02675 ENOG4108JCI Transcriptional regulator AW20_RS02695 ENOG4105BZ1 (ABC) transporter AW20_RS02700 ENOG4105BZ1 (ABC) transporter AW20_RS02715 ENOG4108RPX mosc domain containing protein AW20_RS02720 ENOG4105DND Transcriptional regulator AW20_RS02735 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AW20_RS02740 ENOG4107V2S Transcriptional regulator AW20_RS02785 ENOG410667J hydrolase AW20_RS02805 ENOG4105VEQ Cold shock protein AW20_RS02815 ENOG41068WN AW20_RS02825 ENOG4105C1Q protoporphyrinogen oxidase AW20_RS02855 ENOG4105WCN acetyltransferase AW20_RS02880 ENOG4105EYF MMPL domain protein AW20_RS02890 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AW20_RS02905 ENOG41081I9 integral membrane protein AW20_RS02935 ENOG4108D32 Methyltransferase AW20_RS02960 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AW20_RS02975 ENOG4105C22 threonyL-tRNA synthetase AW20_RS02980 ENOG4105FE9 pseudouridine synthase AW20_RS03005 ENOG4105BZG amino acid carrier protein AW20_RS03025 ENOG4105K70 DNA-binding protein AW20_RS03040 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_RS03045 ENOG4105WQT MbtH domain protein AW20_RS03050 ENOG4105CEY Amp-dependent synthetase and ligase AW20_RS03055 ENOG4105WQI isochorismatase AW20_RS03060 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AW20_RS03065 ENOG4105E4F Isochorismate synthase AW20_RS03070 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AW20_RS03075 ENOG4105FCD Major Facilitator AW20_RS03105 ENOG4105EYH Exonuclease AW20_RS03110 ENOG4107RFY SbcCD D subunit AW20_RS03125 ENOG4105E39 Enoyl-CoA hydratase AW20_RS03130 ENOG4105N14 lysine exporter protein LysE YggA AW20_RS03140 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AW20_RS03145 ENOG4105C1G acyl-Coa dehydrogenase AW20_RS03150 ENOG4105CR4 methylisocitrate lyase AW20_RS03155 ENOG4105DXD 2-methylcitrate dehydratase AW20_RS03165 ENOG4105W8X HesB YadR YfhF-family protein AW20_RS03170 ENOG4105CZM Major Facilitator AW20_RS03175 ENOG4105BZ4 penicillin-binding protein AW20_RS03215 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW20_RS03320 ENOG4108IBT Inherit from COG: transposase AW20_RS03335 ENOG4105SZ6 Thioredoxin AW20_RS03345 ENOG410841Q phosphoesterase PA-phosphatase related protein AW20_RS03350 ENOG4108N23 SpoOM-related protein AW20_RS03390 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AW20_RS03395 ENOG4108JUB Transcriptional regulator AW20_RS03400 ENOG4108TSC N-acetyltransferase AW20_RS03405 ENOG4107S4Y M20 DapE family protein YgeY AW20_RS03420 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW20_RS03445 ENOG4105C37 (CBS) domain AW20_RS03480 ENOG4105E90 ABC transporter AW20_RS03485 ENOG4108IJ8 ABC transporter AW20_RS03515 ENOG4105CMG Carbohydrate kinase AW20_RS03520 ENOG4105CMG Carbohydrate kinase AW20_RS03565 ENOG4105WH1 Two component transcriptional regulator luxr family AW20_RS03570 ENOG4105BZU Histidine kinase AW20_RS03575 ENOG4105D8X mechanosensitive ion channel AW20_RS03610 ENOG4105F0I Aminotransferase AW20_RS03615 ENOG4108MES Periplasmic binding protein AW20_RS03635 ENOG4105CAQ asparagine synthetase AW20_RS03640 ENOG4107Y70 Heat shock protein AW20_RS03645 ENOG4108KF3 Electron transport protein SCO1 SenC AW20_RS03650 ENOG4105E8R UPF0173 metal-dependent hydrolase AW20_RS03655 ENOG4108RCR degv family AW20_RS03665 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AW20_RS03675 ENOG4108UT2 hemolysin iii AW20_RS03680 ENOG4105E9Q Acyl-transferase AW20_RS03685 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AW20_RS03690 ENOG4107RVG penicillin-binding protein AW20_RS03705 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AW20_RS03725 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AW20_RS03755 ENOG4105KD7 acetyltransferase AW20_RS03770 ENOG4105C0A alcohol dehydrogenase AW20_RS03775 ENOG4105CY2 Citrate transporter AW20_RS03780 ENOG4107XGZ Hydrolase AW20_RS03800 ENOG4105C8J )-transporter AW20_RS03815 ENOG41062D9 Histidine kinase AW20_RS03820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS03825 ENOG4107QPK )-transporter AW20_RS03830 ENOG4105BZW Glycerate kinase AW20_RS03925 ENOG4105EC2 ftsk spoIIIe AW20_RS03945 ENOG4105C5S asparaginyl-tRNA synthetase AW20_RS03965 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AW20_RS03990 ENOG4105C75 arginyL-tRNA synthetase AW20_RS03995 ENOG4107YX5 Pfam:DUF548 AW20_RS04030 ENOG4108UUM single-stranded DNA-binding protein AW20_RS04045 ENOG4105C5H ABC transporter AW20_RS04065 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW20_RS04080 ENOG4105MCT stage V sporulation protein S AW20_RS04115 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AW20_RS04120 ENOG4108IFG nitrite reductase, (NAD(P)H) AW20_RS04125 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AW20_RS04130 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW20_RS04135 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AW20_RS04140 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AW20_RS04165 ENOG4108ZAF Molybdopterin AW20_RS04170 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW20_RS04175 ENOG4105D06 uba thif-type nad fad binding protein AW20_RS04180 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AW20_RS04185 ENOG4107V6Q Cyclic nucleotide-binding domain AW20_RS04210 ENOG4105R3A Nitrate reductase AW20_RS04215 ENOG4108IUE nitrate reductase beta subunit AW20_RS04235 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW20_RS04250 ENOG4108V06 Glutathione peroxidase AW20_RS04275 ENOG4105EMN RNA polymerase sigma factor AW20_RS04280 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AW20_RS04290 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_RS04315 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AW20_RS04340 ENOG4105KBJ sporulation protein ytfj AW20_RS04390 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AW20_RS04415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW20_RS04420 ENOG4108JYZ YitT family AW20_RS04425 ENOG41087PP glycosyltransferase MGT family AW20_RS04445 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW20_RS04455 ENOG4108X4Q Hydrolase AW20_RS04480 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AW20_RS04490 ENOG4108VXD carboxy-peptidase AW20_RS04500 ENOG4108ZRV stage ii sporulation protein p AW20_RS04520 ENOG4108Z7R Chaperone CsaA AW20_RS04540 ENOG4105C37 (CBS) domain AW20_RS04545 ENOG4105SXS Protein of unknown function (DUF456) AW20_RS04565 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW20_RS04570 ENOG4108S4H thioesterase Superfamily protein AW20_RS04580 ENOG4108PJD permease AW20_RS04595 ENOG4107T5V SNARE associated Golgi AW20_RS04615 ENOG4105CVJ phosphoglycerate mutase AW20_RS04640 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AW20_RS04650 ENOG4105K4T epimerase AW20_RS04660 ENOG4105DSE periplasmic solute binding protein AW20_RS04730 ENOG4105CKI cobalamin synthesis protein AW20_RS04735 ENOG4107QM2 Aldo Keto reductase AW20_RS04755 ENOG4105DEN Luciferase family AW20_RS04770 ENOG4108WPJ Ferritin-like domain AW20_RS04775 ENOG4108K88 Membrane AW20_RS04795 ENOG4105C8Q Methyl-accepting chemotaxis AW20_RS04820 ENOG4107XZQ multidrug resistance protein AW20_RS04825 ENOG4107SET aldo keto reductase AW20_RS04830 ENOG4105YVS arsR family transcriptional regulator AW20_RS04840 ENOG4105KRN Transcriptional regulator, abrb family AW20_RS04890 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AW20_RS04900 ENOG4105YWU small acid-soluble spore protein AW20_RS04905 ENOG4108WBH protein TIM barrel AW20_RS04920 ENOG4105CEY Amp-dependent synthetase and ligase AW20_RS04925 ENOG4105DUU IucA IucC family protein AW20_RS04935 ENOG4105VRR gCN5-related N-acetyltransferase AW20_RS04940 ENOG4105KT7 mgtC SapB transporter AW20_RS04955 ENOG4105BZU Histidine kinase AW20_RS04960 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_RS04970 ENOG4108KGH TRANSCRIPTIONal AW20_RS04995 ENOG4105D6E homoserine dehydrogenase AW20_RS05020 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AW20_RS05040 ENOG4105BZU Histidine kinase AW20_RS05045 ENOG4105EFI regulatoR AW20_RS05100 ENOG4108JJ8 (ABC) transporter AW20_RS05105 ENOG4108JJ9 ABC, transporter AW20_RS05110 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AW20_RS05115 ENOG4105C4M (Ubiquinol oxidase) subunit I AW20_RS05125 ENOG4105YGB Transcriptional regulator AW20_RS05135 ENOG4105MDS 4-oxalocrotonate tautomerase AW20_RS05145 ENOG4105SKE transcriptional Regulator LysR family AW20_RS05155 ENOG4105C32 Amino acid ABC transporter (Permease) AW20_RS05160 ENOG4108IV0 ABC, transporter AW20_RS05165 ENOG4105C0Z ABC transporter AW20_RS05175 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW20_RS05180 ENOG4108Z7G MaoC domain protein dehydratase AW20_RS05200 ENOG4105CKI cobalamin synthesis protein AW20_RS05215 ENOG4106F5Q Membrane AW20_RS05220 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AW20_RS05230 ENOG4108TVJ Nitroreductase AW20_RS05235 ENOG4107ZXU DSBA oxidoreductase AW20_RS05240 ENOG4108Z40 Transcriptional regulator AW20_RS05245 ENOG4105GZI Transcriptional regulator AW20_RS05250 ENOG4107RT3 EamA-like transporter family AW20_RS05260 ENOG4105KTB nuclear export factor GLE1 AW20_RS05265 ENOG4108T5E Copper resistance protein AW20_RS05310 ENOG4107STQ Multicopper oxidase AW20_RS05315 ENOG4107RAQ aminopeptidase AW20_RS05350 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AW20_RS05355 ENOG4105D9N nucleoside AW20_RS05365 ENOG4107RHR regulatoR AW20_RS05400 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AW20_RS05415 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AW20_RS05435 ENOG41068WN AW20_RS05470 ENOG4105F6J Alpha beta hydrolase fold AW20_RS05490 ENOG4105CYC Transferase AW20_RS05495 ENOG4105DY9 regulatoR AW20_RS05505 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AW20_RS05510 ENOG4105C6X Major Facilitator AW20_RS05535 ENOG4105C7B Threonine dehydratase AW20_RS05545 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AW20_RS05550 ENOG4108ZP8 Acetolactate synthase small subunit AW20_RS05555 ENOG4105C7K acetolactate synthase AW20_RS05560 ENOG4105CM2 brancheD-chain amino acid aminotransferase AW20_RS05565 ENOG4105CHR reductase AW20_RS05570 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AW20_RS05585 ENOG4106KE4 Dehydrogenase AW20_RS05600 ENOG4105H67 Protein of unknown function (DUF421) AW20_RS05605 ENOG4105X5K response regulator receiver protein AW20_RS05615 ENOG4105C8J )-transporter AW20_RS05635 ENOG4105C6T cysteine synthase AW20_RS05640 ENOG4105EU0 Major facilitator Superfamily AW20_RS05655 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AW20_RS05675 ENOG4105CSR polyphosphate kinase 2 AW20_RS05715 ENOG4105FVX AW20_RS05785 ENOG4105C6K Malic enzyme AW20_RS05790 ENOG4108IJ0 Aspartate ammonia-lyase AW20_RS05800 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AW20_RS05820 ENOG4105CJ1 ABC, transporter AW20_RS05855 ENOG4106BRA Membrane AW20_RS05890 ENOG4107QIV Cytochrome c biogenesis protein AW20_RS05910 ENOG4105EC3 peptidase S51, dipeptidase E AW20_RS05940 ENOG4105C9Q fumarate hydratase class II AW20_RS05945 ENOG4105DFD Na H antiporter AW20_RS05960 ENOG4108PJD permease AW20_RS05965 ENOG4105CKI cobalamin synthesis protein AW20_RS05970 ENOG4108UZ3 Transporter AW20_RS05975 ENOG4105DRR Transcriptional regulator, GntR family AW20_RS05985 ENOG4105PGM cation diffusion facilitator family transporter AW20_RS06005 ENOG4105CAQ asparagine synthetase AW20_RS06035 ENOG4105CVJ phosphoglycerate mutase AW20_RS06070 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AW20_RS06075 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AW20_RS06080 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AW20_RS06085 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW20_RS06115 ENOG4105KAC Antibiotic biosynthesis monooxygenase AW20_RS06135 ENOG4108RZE Tetr family transcriptional regulator AW20_RS06160 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW20_RS06165 ENOG4105KTQ flagellar basal-body rod protein AW20_RS06175 ENOG4105D7B Flagellar biosynthesis protein flha AW20_RS06180 ENOG4105D00 flagellar biosynthetic protein flhB AW20_RS06190 ENOG4105VS8 Flagellar biosynthetic protein fliq AW20_RS06195 ENOG4105CN7 Flagellar biosynthetic protein FliP AW20_RS06205 ENOG4105DD5 Flagellar motor switch protein AW20_RS06220 ENOG4105E4C Lytic transglycosylase catalytic AW20_RS06225 ENOG4105I03 Flagellin AW20_RS06280 ENOG4105K64 Glycosyl transferase, family 2 AW20_RS06305 ENOG4105BZE flagellar hook protein, FlgE AW20_RS06340 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AW20_RS06360 ENOG4108ZC9 flagellar basal-body rod protein flgc AW20_RS06365 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AW20_RS06395 ENOG4105E1Q flagellar hook-associated protein AW20_RS06415 ENOG4105BZU Histidine kinase AW20_RS06430 ENOG4105DD5 Flagellar motor switch protein AW20_RS06440 ENOG4107YTP response regulator receiver protein AW20_RS06445 ENOG4105ER2 Ompa motb domain protein AW20_RS06450 ENOG4107R0U MotA TolQ exbB proton channel AW20_RS06460 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AW20_RS06515 ENOG41080C8 DUF218 domain AW20_RS06520 ENOG4105H67 Protein of unknown function (DUF421) AW20_RS06530 ENOG4108Z5V transcriptional regulator, merr family AW20_RS06535 ENOG4105CN5 Metallo-Beta-Lactamase AW20_RS06540 ENOG4107RWR Sodium hydrogen exchanger AW20_RS06550 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW20_RS06615 ENOG41081VK Ribonuclease AW20_RS06635 ENOG4108SZE gCN5-related N-acetyltransferase AW20_RS06650 ENOG4105CPK Glycosyl transferase (Group 1 AW20_RS06725 ENOG4105KHC sulfurtransferase AW20_RS06735 ENOG4108W0I acetyltransferase AW20_RS06745 ENOG410890F Dynamin family AW20_RS06750 ENOG4105DHF Membrane AW20_RS06755 ENOG4105C2W permease AW20_RS06765 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AW20_RS06780 ENOG4105CTD carboxy-peptidase AW20_RS06785 ENOG4105DVT helicase AW20_RS06795 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AW20_RS06845 ENOG4105BZ4 penicillin-binding protein AW20_RS06855 ENOG4105CSM endonuclease III AW20_RS06875 ENOG4105YAC AW20_RS06880 ENOG4105DVT helicase AW20_RS06920 ENOG4105CPK Glycosyl transferase (Group 1 AW20_RS06925 ENOG4105FJR Lmbe family AW20_RS06940 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AW20_RS06945 ENOG4108JYZ YitT family AW20_RS06975 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AW20_RS06980 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AW20_RS06985 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AW20_RS07000 ENOG41068YB TPR repeat-containing protein AW20_RS07005 ENOG4105CIH Imidazole acetol-phosphate transaminase AW20_RS07025 ENOG4105EAH synthase AW20_RS07035 ENOG4105XXQ heptaprenyl diphosphate synthase component I AW20_RS07050 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AW20_RS07080 ENOG41065D1 AW20_RS07085 ENOG4105S2F AW20_RS07120 ENOG4105HDK L-asparaginase AW20_RS07125 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AW20_RS07150 ENOG4108S6Z Negative regulator of genetic competence AW20_RS07155 ENOG4107X2D transcriptional regulator, merr family AW20_RS07170 ENOG4105I7S Abortive infection protein AW20_RS07175 ENOG4105C9U ATP-dependent DNA helicase RecQ AW20_RS07180 ENOG4105T7X AW20_RS07190 ENOG4108SAX Membrane AW20_RS07205 ENOG4108WBT adenosyltransferase AW20_RS07210 ENOG4105BZU Histidine kinase AW20_RS07215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS07220 ENOG4105CRE cytochrome C AW20_RS07225 ENOG4107TWT Cytochrome c biogenesis protein AW20_RS07235 ENOG4105FE9 pseudouridine synthase AW20_RS07245 ENOG4108JIC nucleoside recognition domain protein AW20_RS07250 ENOG4105DZ1 carboxypeptidase AW20_RS07255 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW20_RS07290 ENOG4105BZU Histidine kinase AW20_RS07305 ENOG4105I3N Conserved Protein AW20_RS07325 ENOG4105BZ4 penicillin-binding protein AW20_RS07330 ENOG4107GRR phosphate transport regulator AW20_RS07335 ENOG4105CJ3 phosphate transporter AW20_RS07360 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AW20_RS07385 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AW20_RS07405 ENOG4105WH1 Two component transcriptional regulator luxr family AW20_RS07410 ENOG4105ENE Histidine kinase AW20_RS07430 ENOG4105DFD Na H antiporter AW20_RS07450 ENOG4105C8J )-transporter AW20_RS07460 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AW20_RS07465 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AW20_RS07470 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW20_RS07480 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AW20_RS07485 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AW20_RS07505 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AW20_RS07515 ENOG4105E0M Sulfatase AW20_RS07520 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AW20_RS07535 ENOG4107RVV histidinol phosphate phosphatase, hisj family AW20_RS07570 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AW20_RS07595 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AW20_RS07605 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AW20_RS07610 ENOG4108ZP8 Acetolactate synthase small subunit AW20_RS07615 ENOG4105C7K acetolactate synthase AW20_RS07620 ENOG4105CM2 brancheD-chain amino acid aminotransferase AW20_RS07650 ENOG4105KBJ sporulation protein ytfj AW20_RS07655 ENOG41063Y9 AW20_RS07660 ENOG4105CZN Potassium uptake protein AW20_RS07690 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW20_RS07695 ENOG4107QMU Mate efflux family protein AW20_RS07730 ENOG4105NQC Flavodoxin AW20_RS07755 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW20_RS07765 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AW20_RS07770 ENOG4105EA8 2-Nitropropane dioxygenase AW20_RS07775 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AW20_RS07815 ENOG4105CJ1 ABC, transporter AW20_RS07825 ENOG4105CZV ABC transporter AW20_RS07830 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AW20_RS07835 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW20_RS07855 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AW20_RS07900 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AW20_RS07905 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AW20_RS07915 ENOG4105BZU Histidine kinase AW20_RS07925 ENOG4106DF1 AW20_RS07935 ENOG41090MY MarR family Transcriptional regulator AW20_RS07940 ENOG4105BZU Histidine kinase AW20_RS07950 ENOG4105PXI polysaccharide deacetylase AW20_RS07975 ENOG4105E98 transcriptional regulator DeoR family AW20_RS08005 ENOG4105C4Y ABC transporter AW20_RS08025 ENOG4105MWK D-amino acid dehydrogenase, small subunit AW20_RS08035 ENOG4105CHR reductase AW20_RS08055 ENOG4108Z7G MaoC domain protein dehydratase AW20_RS08060 ENOG410681C small acid-soluble spore protein AW20_RS08065 ENOG4105CZN Potassium uptake protein AW20_RS08070 ENOG4107TS3 membrane protein, TerC AW20_RS08075 ENOG4108QTI )-transporter AW20_RS08085 ENOG4106A3R peptidase AW20_RS08105 ENOG4105JXH GntR family transcriptional regulator AW20_RS08110 ENOG4105BZU Histidine kinase AW20_RS08115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS08130 ENOG4105CQB FAD linked oxidase domain protein AW20_RS08135 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AW20_RS08140 ENOG4105K4I Scp-like extracellular AW20_RS08150 ENOG4108YBP pseudouridine synthase AW20_RS08160 ENOG4105EYF MMPL domain protein AW20_RS08170 ENOG4107RUE extracellular solute-binding protein family 1 AW20_RS08175 ENOG4105D38 putrescine abc transporter AW20_RS08180 ENOG4105F38 ABC transporter, permease AW20_RS08185 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW20_RS08190 ENOG4105C26 Dehydrogenase AW20_RS08225 ENOG4105VFR signal peptidase AW20_RS08230 ENOG4105DZ1 carboxypeptidase AW20_RS08240 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AW20_RS08300 ENOG4105VZ8 Transcriptional regulator AW20_RS08310 ENOG4105C7S Dehydrogenase AW20_RS08400 ENOG4105DDQ anthranilate synthase AW20_RS08415 ENOG4105CK7 Sodium proline symporter AW20_RS08490 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AW20_RS08500 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AW20_RS08505 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AW20_RS08525 ENOG4107TVC Glycosyl transferase, family 2 AW20_RS08545 ENOG4105K64 Glycosyl transferase, family 2 AW20_RS08565 ENOG4105EMS pseudouridine synthase AW20_RS08585 ENOG4105MIX Adenylate cyclase AW20_RS08590 ENOG4108Z18 K06886 hemoglobin AW20_RS08605 ENOG4105DPN Oligoendopeptidase f AW20_RS08615 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW20_RS08625 ENOG4108ZCF integral membrane protein AW20_RS08650 ENOG4105UQX Mate efflux family protein AW20_RS08655 ENOG4108JQ7 (ABC) transporter AW20_RS08665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW20_RS08670 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW20_RS08685 ENOG4105C31 Tryptophanyl-tRNA synthetase AW20_RS08700 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AW20_RS08705 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW20_RS08730 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AW20_RS08745 ENOG4108KP7 hydrolase AW20_RS08755 ENOG41073B9 AW20_RS08760 ENOG4107AYK membrAne AW20_RS08770 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW20_RS08780 ENOG4105QNR S1 RNA binding domain protein AW20_RS08805 ENOG4105BZU Histidine kinase AW20_RS08810 ENOG4105CH6 catalase AW20_RS08815 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AW20_RS08820 ENOG4105CAQ asparagine synthetase AW20_RS08845 ENOG4105ERH Fumarylacetoacetate hydrolase AW20_RS08890 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AW20_RS08895 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AW20_RS08910 ENOG4105XVF Competence transcription factor AW20_RS08940 ENOG4107QP3 malate synthase g AW20_RS08965 ENOG4105C8Q Methyl-accepting chemotaxis AW20_RS08970 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AW20_RS08995 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_RS09015 ENOG41086D8 Transcriptional regulator AW20_RS09020 ENOG4108AEY RNA polymerase sigma factor AW20_RS09030 ENOG4107TVP HD domain protein AW20_RS09080 ENOG4105CNA YD repeat protein AW20_RS09110 ENOG4105CEY Amp-dependent synthetase and ligase AW20_RS09120 ENOG4105DF9 Lipoate-protein, ligase AW20_RS09125 ENOG4108RQ5 Beta-lactamase domain-containing protein AW20_RS09130 ENOG4106AXD AW20_RS09160 ENOG4105ECB domain protein AW20_RS09175 ENOG4105NA0 Transcriptional regulator AW20_RS09200 ENOG4105C1Q protoporphyrinogen oxidase AW20_RS09210 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AW20_RS09215 ENOG4105BZ4 penicillin-binding protein AW20_RS09220 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AW20_RS09225 ENOG4105CKV Membrane AW20_RS09230 ENOG410905X membrane-flanked domain protein AW20_RS09285 ENOG410905X membrane-flanked domain protein AW20_RS09315 ENOG4105K59 histidine triad (HIT) protein AW20_RS09345 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW20_RS09350 ENOG4105EEM helicase AW20_RS09360 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_RS09365 ENOG4105C57 major facilitator superfamily AW20_RS09390 ENOG4105EMN RNA polymerase sigma factor AW20_RS09405 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AW20_RS09420 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AW20_RS09440 ENOG4108MUZ hydrolase AW20_RS09460 ENOG4105EQ0 Major Facilitator superfamily AW20_RS09465 ENOG4108IND Tetr family transcriptional regulator AW20_RS09480 ENOG4105D7V transposase AW20_RS09490 ENOG4107VRP DNA repair exonuclease AW20_RS09550 ENOG4105BZU Histidine kinase AW20_RS09555 ENOG4105BZU Histidine kinase AW20_RS09560 ENOG4108MJI response regulator AW20_RS09570 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_RS09580 ENOG4105WN5 stage II sporulation protein AW20_RS09645 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AW20_RS09670 ENOG410847I Transcriptional regulator, BadM Rrf2 family AW20_RS09675 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AW20_RS09690 ENOG4105CMT Dihydroxyacetone kinase AW20_RS09710 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AW20_RS09730 ENOG4108IG5 Transcriptional regulator AW20_RS09735 ENOG4107P5I polyketide synthase AW20_RS09785 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_RS09825 ENOG4105CDU Replicative dna helicase AW20_RS09875 ENOG4108MRH transcriptional regulatory protein AW20_RS09885 ENOG4105CSH Transporter AW20_RS09915 ENOG4108JQ7 (ABC) transporter AW20_RS09925 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW20_RS09970 ENOG4105CTU Proline racemase AW20_RS09990 ENOG4105DER m42 family AW20_RS10010 ENOG4105CGU Enoyl-CoA hydratase AW20_RS10025 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW20_RS10030 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW20_RS10040 ENOG4106AKK s-layer domain-containing protein AW20_RS10080 ENOG4105CHH sulfate transporter AW20_RS10095 ENOG4105D4P Coproporphyrinogen iii oxidase AW20_RS10125 ENOG4107FQX Alpha-acetolactate decarboxylase AW20_RS10160 ENOG410839P AW20_RS10175 ENOG4105CDA abc transporter atp-binding protein AW20_RS10180 ENOG4105DRP amino acid AbC transporter AW20_RS10195 ENOG4105BZ1 (ABC) transporter AW20_RS10205 ENOG4105C26 Dehydrogenase AW20_RS10215 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AW20_RS10220 ENOG4105D5Q Arginine ornithine antiporter AW20_RS10230 ENOG4105CH6 catalase AW20_RS10235 ENOG4107RKG DJ-1/PfpI family AW20_RS10245 ENOG4105E5W Transporter AW20_RS10250 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AW20_RS10255 ENOG4105NF4 modulator of drug activity AW20_RS10280 ENOG4105KPY Small multidrug resistance protein AW20_RS10295 ENOG4108YXU transcriptional regulator AsnC family AW20_RS10300 ENOG4108PCN EamA-like transporter family AW20_RS10335 ENOG4106KNT transcriptional regulator AW20_RS10345 ENOG4107RWR Sodium hydrogen exchanger AW20_RS10350 ENOG4105CUB amino acid AW20_RS10385 ENOG4107T5V SNARE associated Golgi AW20_RS10420 ENOG4105WEF catalase AW20_RS10450 ENOG4105C19 ABC transporter AW20_RS10455 ENOG4107RBB ABC transporter, permease AW20_RS10460 ENOG41069ER domain protein AW20_RS10480 ENOG4105VZJ PTS System AW20_RS10485 ENOG4105VCP PTS System AW20_RS10490 ENOG4105EMD TRANSCRIPTIONal AW20_RS10515 ENOG4108KGH TRANSCRIPTIONal AW20_RS10525 ENOG41087NI Sulfite exporter TauE/SafE AW20_RS10530 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AW20_RS10540 ENOG41085GJ domain protein AW20_RS10545 ENOG4105VFE sira family AW20_RS10550 ENOG4107TPS domain protein AW20_RS10555 ENOG4105VFE sira family AW20_RS10560 ENOG4105XTG Pfam:DUF156 AW20_RS10565 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AW20_RS10590 ENOG4105ED1 spovr family AW20_RS10595 ENOG4107Y03 Nitroreductase AW20_RS10655 ENOG4105C5Y PTS System AW20_RS10685 ENOG4105C7N Xanthine uracil vitamin C permease AW20_RS10700 ENOG4108INS Transcriptional regulator AW20_RS10755 ENOG4105DWF phosphomethylpyrimidine kinase AW20_RS10760 ENOG4105D06 uba thif-type nad fad binding protein AW20_RS10775 ENOG41080HI glycine oxidase AW20_RS10780 ENOG4108VEU Thiamine monophosphate synthase AW20_RS10790 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AW20_RS10800 ENOG4105ETU transcriptional activator (TenA AW20_RS10825 ENOG41080XQ Signal transduction protein with cbs domains AW20_RS10950 ENOG4105E2Z phosphate ABC transporter (Permease AW20_RS10955 ENOG4105C8U phosphate abc transporter AW20_RS10960 ENOG4105CVA phosphate AW20_RS10965 ENOG4105CE1 Ferrous iron transport protein b AW20_RS10970 ENOG4105CE1 Ferrous iron transport protein b AW20_RS10975 ENOG4105CE1 Ferrous iron transport protein b AW20_RS10985 ENOG4108NHD germination protein AW20_RS11000 ENOG4105E1V na solute symporter AW20_RS11005 ENOG4106CAD Protein of unknown function (DUF3311) AW20_RS11020 ENOG4108IQI permease AW20_RS11025 ENOG4105E2S oxidase) subunit II AW20_RS11030 ENOG4105BZ9 Cytochrome C oxidase, subunit I AW20_RS11070 ENOG4105C7N Xanthine uracil vitamin C permease AW20_RS11095 ENOG4105DUX Transporter AW20_RS11105 ENOG4107D63 AW20_RS11110 ENOG4105VZ8 Transcriptional regulator AW20_RS11115 ENOG41069ER domain protein AW20_RS11120 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AW20_RS11125 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW20_RS11190 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AW20_RS11195 ENOG4105CNN ABC, transporter AW20_RS11210 ENOG4108RVA ribokinase AW20_RS11215 ENOG4105ETE Transcriptional regulator (LacI family AW20_RS11230 ENOG41067TZ transcriptional regulator, MarR family AW20_RS11235 ENOG4105CXY transporter AW20_RS11245 ENOG4108JQ7 (ABC) transporter AW20_RS11250 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW20_RS11260 ENOG4105DEF Extracellular solute-binding protein, family 5 AW20_RS11270 ENOG41068KF Universal stress protein AW20_RS11275 ENOG4105CHH sulfate transporter AW20_RS11285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS11290 ENOG4105BZU Histidine kinase AW20_RS11295 ENOG4105NAE bifunctional deaminase-reductase domain protein AW20_RS11300 ENOG4105D29 Helix-turn-helix type 11 domain protein AW20_RS11325 ENOG4108IQI permease AW20_RS11330 ENOG4105DRP amino acid AbC transporter AW20_RS11335 ENOG4105EAD ABC transporter AW20_RS11340 ENOG4105CT1 (ABC) transporter AW20_RS11345 ENOG4105CDA abc transporter atp-binding protein AW20_RS11350 ENOG4105BZG amino acid carrier protein AW20_RS11355 ENOG4105CRN Aminoglycoside phosphotransferase AW20_RS11365 ENOG4105E1K spore germination protein AW20_RS11380 ENOG4105CG3 alpha amylase, catalytic region AW20_RS11385 ENOG4105C5Y PTS System AW20_RS11390 ENOG4107414 GntR family transcriptional regulator AW20_RS11395 ENOG4105D5Q Arginine ornithine antiporter AW20_RS11400 ENOG4105BZU Histidine kinase AW20_RS11415 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW20_RS11420 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AW20_RS11425 ENOG4107T89 von Willebrand factor, type A AW20_RS11445 ENOG4105DMQ Methyltransferase AW20_RS11450 ENOG4105E0A ABC, transporter AW20_RS11455 ENOG4108IHU transport system permease protein AW20_RS11460 ENOG4105DQ5 transport system permease protein AW20_RS11465 ENOG4108MES Periplasmic binding protein AW20_RS11470 ENOG4105DUX Transporter AW20_RS11485 ENOG4105DAA L-lactate AW20_RS11490 ENOG4108IJ0 Aspartate ammonia-lyase AW20_RS11495 ENOG4105C37 (CBS) domain AW20_RS11500 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AW20_RS11505 ENOG4105D9N nucleoside AW20_RS11510 ENOG4108KGH TRANSCRIPTIONal AW20_RS11515 ENOG41073R8 VanW family AW20_RS11545 ENOG4105DAP Nicotinate phosphoribosyltransferase AW20_RS11550 ENOG4105C59 p-type ATPase AW20_RS11560 ENOG4105CUB amino acid AW20_RS11580 ENOG4108JB9 formate dehydrogenase AW20_RS11585 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AW20_RS11590 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AW20_RS11600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS11605 ENOG4105BZU Histidine kinase AW20_RS11615 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW20_RS11620 ENOG4108UZ3 Transporter AW20_RS11630 ENOG4105C6K Malic enzyme AW20_RS11640 ENOG4108MRH transcriptional regulatory protein AW20_RS11665 ENOG4105US7 Histidine kinase AW20_RS11670 ENOG4108STX response regulator AW20_RS11675 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AW20_RS11680 ENOG4105BZ7 extracellular solute-binding protein family 1 AW20_RS11685 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AW20_RS11690 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AW20_RS11695 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW20_RS11700 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AW20_RS11720 ENOG4105D4T Citrate transporter AW20_RS11730 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AW20_RS11740 ENOG4105DZ6 Band 7 protein AW20_RS11755 ENOG4105C94 Transporter AW20_RS11780 ENOG4105CYN Serine protein kinase AW20_RS11790 ENOG4105BZU Histidine kinase AW20_RS11795 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AW20_RS11805 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AW20_RS11820 ENOG4108JQC penicillin-binding protein 1A AW20_RS11935 ENOG4105G5W regulator Fur family AW20_RS11940 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW20_RS11960 ENOG4108IUW ABC transporter AW20_RS11970 ENOG4105CBC glutamate synthase AW20_RS11975 ENOG4107NBY Membrane AW20_RS11980 ENOG4105BZ1 (ABC) transporter AW20_RS12000 ENOG4106BXE AW20_RS12005 ENOG4105CEN a g-specific adenine glycosylase AW20_RS12010 ENOG41067AE Membrane-bound metal-dependent hydrolase AW20_RS12040 ENOG4105ECP epimerase AW20_RS12045 ENOG4105CI2 imidazolone-5-propionate hydrolase AW20_RS12065 ENOG4105F1A Pyruvate formate-lyase AW20_RS12085 ENOG4105C3I Nad-dependent epimerase dehydratase AW20_RS12090 ENOG4107QQG Dehydrogenase AW20_RS12100 ENOG4105CKK Glycosyl transferase, family 2 AW20_RS12115 ENOG4108A04 Beta-lactamase AW20_RS12160 ENOG4108IQI permease AW20_RS12170 ENOG4108JUB Transcriptional regulator AW20_RS12180 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AW20_RS12455 ENOG4108IMY Transcriptional regulator AW20_RS12460 ENOG4105VTR Integrase AW20_RS12465 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AW20_RS12505 ENOG4105UPD Calcium Proton AW20_RS12510 ENOG410606W general stress protein AW20_RS12525 ENOG4107ZTW SNARE associated Golgi AW20_RS12545 ENOG4108IPJ Membrane AW20_RS12550 ENOG4105C59 p-type ATPase AW20_RS12555 ENOG4107U9T Pfam:Ribonuclease_BN AW20_RS12565 ENOG4105KJF protein tyrosine phosphatase AW20_RS12585 ENOG4108TTB tellurium resistance protein AW20_RS12590 ENOG4107TS3 membrane protein, TerC AW20_RS12595 ENOG4106FN3 tellurium resistance protein AW20_RS12600 ENOG4106FN3 tellurium resistance protein AW20_RS12605 ENOG4108N0M stress protein AW20_RS12620 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AW20_RS12635 ENOG4105DEU major facilitator superfamily AW20_RS12655 ENOG41062JF Transcriptional regulator AW20_RS12680 ENOG4105C5H ABC transporter AW20_RS12695 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AW20_RS12710 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AW20_RS12740 ENOG4105CI1 PTS System AW20_RS12750 ENOG4105C8Q Methyl-accepting chemotaxis AW20_RS12755 ENOG4105C8Q Methyl-accepting chemotaxis AW20_RS12765 ENOG4105EAB amino acid AbC transporter AW20_RS12770 ENOG4105E5Q amino acid AbC transporter AW20_RS12785 ENOG4105D2S major facilitator superfamily AW20_RS12790 ENOG410756H nucleotidyltransferase AW20_RS12810 ENOG4105BZU Histidine kinase AW20_RS12835 ENOG4106UIA AW20_RS12840 ENOG4106UIA AW20_RS12865 ENOG4108V5C ABC transporter AW20_RS12870 ENOG4105DQ5 transport system permease protein AW20_RS12875 ENOG4105EHG Permease protein AW20_RS12895 ENOG4105D3R alkyl hydroperoxide reductase AW20_RS12915 ENOG4105DFD Na H antiporter AW20_RS12925 ENOG4105DTQ mandelate racemase muconate lactonizing AW20_RS12940 ENOG4108W15 Protein of unknown function (DUF1456) AW20_RS12955 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AW20_RS12960 ENOG4105D9N nucleoside AW20_RS12980 ENOG4105KPY Small multidrug resistance protein AW20_RS12985 ENOG4105C26 Dehydrogenase AW20_RS12995 ENOG4108JPW Aminotransferase AW20_RS13000 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AW20_RS13005 ENOG4105CBD Diacylglycerol kinase AW20_RS13030 ENOG410834F Transcriptional regulator AW20_RS13050 ENOG4105D01 (LipO)protein AW20_RS13055 ENOG4108UMI ABC transporter, permease AW20_RS13060 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW20_RS13065 ENOG4108W2Y isochorismatase AW20_RS13095 ENOG4105C4R Atp-dependent dna helicase AW20_RS13120 ENOG4105C12 Phosphoribosylglycinamide synthetase AW20_RS13130 ENOG4108V3E phosphoribosylglycinamide formyltransferase AW20_RS13155 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AW20_RS13165 ENOG4105C83 adenylosuccinate lyase AW20_RS13170 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AW20_RS13175 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AW20_RS13200 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_RS13220 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW20_RS13260 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW20_RS13290 ENOG4105BZU Histidine kinase AW20_RS13300 ENOG4105C7N Xanthine uracil vitamin C permease AW20_RS13320 ENOG4108TYN CAAX amino terminal protease family protein AW20_RS13335 ENOG4105C5H ABC transporter AW20_RS13345 ENOG410801F ribosomal-protein-alanine acetyltransferase AW20_RS13350 ENOG41072GX Peptidase M22 Glycoprotease AW20_RS13355 ENOG4105K8N protein family UPF0079, ATPase AW20_RS13455 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AW20_RS13465 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW20_RS13470 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AW20_RS13480 ENOG4107ZXI Rhomboid family AW20_RS13495 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AW20_RS13510 ENOG4108SC4 )-transporter AW20_RS13520 ENOG4105ERH Fumarylacetoacetate hydrolase AW20_RS13525 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AW20_RS13550 ENOG4108JQ7 (ABC) transporter AW20_RS13555 ENOG4105C3U ABC transporter AW20_RS13560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW20_RS13570 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AW20_RS13585 ENOG4105C5H ABC transporter AW20_RS13610 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AW20_RS13615 ENOG4108RE7 deoxyribonuclease AW20_RS13630 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AW20_RS13650 ENOG4105F6E Acyl-transferase AW20_RS13665 ENOG4105EGI Transcriptional regulator AW20_RS13680 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AW20_RS13695 ENOG4105E0C molybdate abc transporter AW20_RS13705 ENOG4107XDY Nicotinamide Mononucleotide Transporter AW20_RS13715 ENOG4105II7 pyrroline-5-carboxylate reductase AW20_RS13725 ENOG4108J59 Extracellular solute-binding protein, family 5 AW20_RS13730 ENOG4108J59 Extracellular solute-binding protein, family 5 AW20_RS13760 ENOG4108JQ7 (ABC) transporter AW20_RS13765 ENOG4105C3U ABC transporter AW20_RS13770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW20_RS13775 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW20_RS13805 ENOG4105IQ5 FAD linked oxidase domain protein AW20_RS13820 ENOG4105D01 (LipO)protein AW20_RS13825 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW20_RS13830 ENOG4108UMI ABC transporter, permease AW20_RS13870 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AW20_RS13875 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AW20_RS13895 ENOG4108VQT Alpha beta hydrolase fold protein AW20_RS13900 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AW20_RS13915 ENOG4107U5W ybbr family AW20_RS13920 ENOG4105C8B TIGR00159 family AW20_RS14005 ENOG4108NMV polysaccharide deacetylase AW20_RS14020 ENOG4105D1F ATP-binding protein AW20_RS14050 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AW20_RS14095 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AW20_RS14105 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AW20_RS14235 ENOG4105XPM ribosomal protein AW20_RS14240 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AW20_RS14250 ENOG4107Y49 methyltransferase AW20_RS14275 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AW20_RS14290 ENOG4105QIV RNA polymerase AW20_RS14295 ENOG4105M0M Tetracycline resistance protein AW20_RS14300 ENOG4105C2N RNA methyltransferase TrmH family group 3 AW20_RS14315 ENOG4105D7W serine acetyltransferase AW20_RS14335 ENOG4105CTP PilT protein domain protein AW20_RS14345 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AW20_RS14360 ENOG4108Z0C Uvrb UvrC protein AW20_RS14390 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AW20_RS14400 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AW20_RS14405 ENOG4105KRF dihydroneopterin aldolase AW20_RS14410 ENOG4105EEI dihydropteroate synthase AW20_RS14415 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AW20_RS14420 ENOG4105DDQ anthranilate synthase AW20_RS14425 ENOG4105CRQ synthase (Component I) AW20_RS14430 ENOG4105C6T cysteine synthase AW20_RS14445 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AW20_RS14450 ENOG4108UGV hypoxanthine phosphoribosyltransferase AW20_RS14455 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AW20_RS14475 ENOG41060GV RNA binding s1 domain protein AW20_RS14490 ENOG4105VYY sporulation protein yabp AW20_RS14495 ENOG41082I2 s4 domain protein AW20_RS14500 ENOG4108IY2 MazG family AW20_RS14510 ENOG4108M14 stage v sporulation protein t AW20_RS14515 ENOG4108JA2 transcriptioN-repair coupling factor AW20_RS14545 ENOG4105KME endoribonuclease L-psp AW20_RS14550 ENOG4105DFT pur operon repressor AW20_RS14565 ENOG4105W42 Veg protein AW20_RS14570 ENOG4105XFA sporulation peptidase YabG AW20_RS14580 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AW20_RS14585 ENOG4105F8V Hydrolase, tatD family AW20_RS14595 ENOG4105KRN Transcriptional regulator, abrb family AW20_RS14600 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AW20_RS14610 ENOG41060K3 Methyltransferase AW20_RS14620 ENOG4105MA4 psp1 domain protein AW20_RS14625 ENOG4105FA2 dna polymerase iii AW20_RS14635 ENOG4105CXN decarboxylase AW20_RS14670 ENOG41067KS pro-sigma K processing AW20_RS14690 ENOG4105C6E dna polymerase iii AW20_RS14695 ENOG4108Z6B deaminase AW20_RS14705 ENOG4105GTG Isochorismatase AW20_RS14715 ENOG4105ZMH deoxynucleoside kinase AW20_RS14750 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AW20_RS14785 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW20_RS14800 ENOG410848D S4 domain protein YaaA AW20_RS14805 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AW20_RS14825 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AW20_RS14855 ENOG4107QJE Chromosome Partitioning Protein AW20_RS14860 ENOG4105FA0 parb-like partition protein AW20_RS14865 ENOG4108ZDA Sporulation protein YyaC AW20_RS14870 ENOG4105D8X mechanosensitive ion channel AW20_RS14875 ENOG4105VDK protein, conserved in bacteria AW20_RS14880 ENOG4105C3G gtp-binding protein AW20_RS14890 ENOG4108UUM single-stranded DNA-binding protein AW20_RS14900 ENOG4108XMW Membrane AW20_RS14905 ENOG4105BZR domain protein AW20_RS14915 ENOG4105CDU Replicative dna helicase AW20_RS14945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS14950 ENOG4105BZU Histidine kinase AW20_RS14965 ENOG4105Q2H domain protein AW20_RS14970 ENOG4105C0H protease AW20_RS14990 ENOG4105DPN Oligoendopeptidase f AW20_RS15005 ENOG4105C1J atp-dependent rna helicase AW20_RS15015 ENOG4108UT2 hemolysin iii AW20_RS15020 ENOG4105CMR udp-glucose 4-epimerase AW20_RS15030 ENOG4105IW1 AmiS UreI transporter AW20_RS15040 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW20_RS15055 ENOG4107RGD Major Facilitator superfamily AW20_RS15060 ENOG4108HRK Histidine kinase AW20_RS15065 ENOG4105DY9 regulatoR AW20_RS15080 ENOG4106F5Q Membrane AW20_RS15085 ENOG4105E0X reductase AW20_RS15095 ENOG41067SE Tetr family transcriptional regulator AW20_RS15100 ENOG4105CKK Glycosyl transferase, family 2 AW20_RS15130 ENOG4105C5H ABC transporter AW20_RS15135 ENOG4105JEU Glycosyl transferase, family 2 AW20_RS15145 ENOG4108S4H thioesterase Superfamily protein AW20_RS15155 ENOG4106YBV Methyl-accepting chemotaxis AW20_RS15160 ENOG4105EN6 Membrane AW20_RS15180 ENOG41079KZ Major Facilitator Superfamily AW20_RS15185 ENOG4105DY9 regulatoR AW20_RS15190 ENOG4105D22 carbon starvation protein AW20_RS15195 ENOG4105VCD cytoplasmic protein AW20_RS15200 ENOG4105BZU Histidine kinase AW20_RS15205 ENOG4105DWF phosphomethylpyrimidine kinase AW20_RS15215 ENOG4105WH1 Two component transcriptional regulator luxr family AW20_RS15225 ENOG4108Y4K DNA-binding transcriptional activator AW20_RS15250 ENOG4105D6E homoserine dehydrogenase AW20_RS15265 ENOG41090WU lipolytic protein G-D-S-L family AW20_RS15270 ENOG4105CJ1 ABC, transporter AW20_RS15275 ENOG4108TU7 Inherit from COG: (ABC) transporter AW20_RS15285 ENOG4105VCH membrane AW20_RS15290 ENOG410667J hydrolase AW20_RS15320 ENOG4108VKI Cell wall hydrolase AW20_RS15335 ENOG4108IJ2 phosphate acetyltransferase AW20_RS15350 ENOG4108VCI transcription factor, rsfa family AW20_RS15370 ENOG4105EHG Permease protein AW20_RS15375 ENOG4105E0A ABC, transporter AW20_RS15380 ENOG4108MES Periplasmic binding protein AW20_RS15385 ENOG4105DCI Phosphohydrolase AW20_RS15390 ENOG41069HH 4-oxalocrotonate tautomerase AW20_RS15395 ENOG4108Z4T Peptidase M50 AW20_RS15400 ENOG4108XFG YwhD family AW20_RS15405 ENOG4105BZ4 penicillin-binding protein AW20_RS15410 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AW20_RS15415 ENOG4107SWG transcriptional regulator MERR family AW20_RS15420 ENOG4105DXB Major Facilitator superfamily AW20_RS15430 ENOG4105CYW agmatinase AW20_RS15455 ENOG410684U Domain of unknown function (DUF1934) AW20_RS15465 ENOG4105EMN RNA polymerase sigma factor AW20_RS15485 ENOG4105IIU Aminopeptidase AW20_RS15505 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AW20_RS15510 ENOG4108M15 ABC transporter AW20_RS15515 ENOG4105KCT ABC transporter AW20_RS15520 ENOG4105BZU Histidine kinase AW20_RS15540 ENOG4105BZU Histidine kinase AW20_RS15555 ENOG4105DF6 Fe-S oxidoreductase AW20_RS15565 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AW20_RS15570 ENOG4105C1G acyl-Coa dehydrogenase AW20_RS15615 ENOG4105CBT Fructose-1,6-bisphosphatase AW20_RS15620 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AW20_RS15640 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AW20_RS15645 ENOG4108ZXQ stage ii sporulation protein r AW20_RS15655 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AW20_RS15670 ENOG4107XC4 flavin reductase domain protein, FMN-binding AW20_RS15675 ENOG4108VGI doxx family AW20_RS15690 ENOG4108YZG isomerase AW20_RS15720 ENOG41062M3 atp synthase AW20_RS15725 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AW20_RS15775 ENOG4105BZU Histidine kinase AW20_RS15790 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AW20_RS15795 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW20_RS15820 ENOG4105D65 subunit l AW20_RS15825 ENOG4105C8S subunit m AW20_RS15830 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW20_RS15835 ENOG4106778 Protein of unknown function (DUF1146) AW20_RS15855 ENOG4108IUW ABC transporter AW20_RS15860 ENOG4105DY9 regulatoR AW20_RS15875 ENOG4105FRN stage II sporulation protein AW20_RS15890 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AW20_RS15945 ENOG4105EY8 ABC transporter AW20_RS15950 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AW20_RS15965 ENOG4105CMR udp-glucose 4-epimerase AW20_RS15970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS15975 ENOG4105BZU Histidine kinase AW20_RS15990 ENOG4105CXY transporter AW20_RS16010 ENOG4105C19 ABC transporter AW20_RS16015 ENOG4107RBB ABC transporter, permease AW20_RS16025 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_RS16055 ENOG4105C0D helicase AW20_RS16060 ENOG4105KBK Zinc finger, swim domain protein AW20_RS16085 ENOG41069ER domain protein AW20_RS16090 ENOG4105C94 Transporter AW20_RS16125 ENOG4105E0M Sulfatase AW20_RS16135 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AW20_RS16145 ENOG4105DAA L-lactate AW20_RS16190 ENOG4107RSM transcriptional regulator AW20_RS16195 ENOG4105ECB domain protein AW20_RS16200 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_RS16215 ENOG4105VZJ PTS System AW20_RS16225 ENOG4105VCP PTS System AW20_RS16230 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AW20_RS16235 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AW20_RS16245 ENOG4105CK1 PTS System AW20_RS16250 ENOG4105VCP PTS System AW20_RS16255 ENOG4105F8D glycoside hydrolase family 4 AW20_RS16275 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AW20_RS16285 ENOG4105ESV Glycosyl transferase, family 4 AW20_RS16290 ENOG4105C6Y Udp-glucose 6-dehydrogenase AW20_RS16295 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AW20_RS16300 ENOG4108KGH TRANSCRIPTIONal AW20_RS16305 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AW20_RS16320 ENOG4105KVH Transcriptional regulator AW20_RS16335 ENOG41081UC Inherit from COG: Competence protein AW20_RS16340 ENOG4105VEQ Cold shock protein AW20_RS16345 ENOG4105MS2 ribosomal subunit Interface protein AW20_RS16350 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AW20_RS16370 ENOG4105CAK Cell division ATP-binding protein ftsE AW20_RS16375 ENOG4105CRP Part of the ABC transporter FtsEX involved in AW20_RS16380 ENOG4105CN1 protease AW20_RS16390 ENOG4105BZ1 (ABC) transporter AW20_RS16405 ENOG4108WS4 fmn reductase AW20_RS16415 ENOG4105DUM transcriptional regulator, lysR family AW20_RS16420 ENOG4105HMI Membrane AW20_RS16445 ENOG4107TXC Transcriptional regulator AW20_RS16460 ENOG4105D7V transposase AW20_RS16465 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AW20_RS16470 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW20_RS16480 ENOG41086DT Membrane protein of unknown function AW20_RS16500 ENOG4108S4C acetyltransferase AW20_RS16510 ENOG4105C3M thioredoxin reductase AW20_RS16520 ENOG4108Z4K mutator MutT protein AW20_RS16530 ENOG4105CHW UPF0052 protein AW20_RS16540 ENOG4105KRI phosphocarrier protein (HPr AW20_RS16545 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AW20_RS16550 ENOG4105H67 Protein of unknown function (DUF421) AW20_RS16565 ENOG4105CZ3 stage V sporulation protein ad AW20_RS16570 ENOG41090VF Stage v sporulation protein ac AW20_RS16590 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_RS16615 ENOG4105CP7 Triose-phosphate isomerase AW20_RS16620 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AW20_RS16630 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW20_RS16655 ENOG4105EFC phage portal protein HK97 family AW20_RS16755 ENOG41067MG lrgb family AW20_RS16760 ENOG4105XZU Preprotein translocase, subunit SecG AW20_RS16770 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AW20_RS16780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS16795 ENOG4105CM4 permease protein AW20_RS16800 ENOG4108IPW abc transporter atp-binding protein AW20_RS16820 ENOG4108MK9 spermidine N(1)-acetyltransferase AW20_RS16835 ENOG4105WMR Protein CrcB homolog AW20_RS16840 ENOG4105WMR Protein CrcB homolog AW20_RS16850 ENOG4105C8Q Methyl-accepting chemotaxis AW20_RS16860 ENOG4105D4A Cell wall formation (By similarity) AW20_RS16865 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AW20_RS16880 ENOG4105KVH Transcriptional regulator AW20_RS16885 ENOG4105F27 Major Facilitator AW20_RS16890 ENOG4105CV8 reductase AW20_RS16905 ENOG4108RYK Nad-dependent epimerase dehydratase AW20_RS16920 ENOG4105D9N nucleoside AW20_RS16925 ENOG4105D9N nucleoside AW20_RS16950 ENOG4108URH decarboxylase AW20_RS16965 ENOG4108RMU ferritin dps family protein AW20_RS16980 ENOG4105NCW Trka-c domain protein AW20_RS16985 ENOG4107S91 Sodium hydrogen exchanger AW20_RS17005 ENOG4105D4Y metalloprotease AW20_RS17010 ENOG4105VG1 fes assembly suf system protein AW20_RS17035 ENOG4105BZU Histidine kinase AW20_RS17040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS17045 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AW20_RS17055 ENOG4107ZTW SNARE associated Golgi AW20_RS17090 ENOG4107AYK membrAne AW20_RS17100 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AW20_RS17110 ENOG4107R7I amino acid AW20_RS17115 ENOG4108SUT Major Facilitator Superfamily AW20_RS17135 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AW20_RS17155 ENOG4105DZ1 carboxypeptidase AW20_RS17170 ENOG4105CHU acetyl-coa acetyltransferase AW20_RS17180 ENOG4105C1G acyl-Coa dehydrogenase AW20_RS17185 ENOG4108W8B Beta-lactamase domain protein AW20_RS17215 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AW20_RS17265 ENOG41080E8 Transcriptional regulator, Spx MgsR family AW20_RS17300 ENOG4108UMI ABC transporter, permease AW20_RS17305 ENOG4105D01 (LipO)protein AW20_RS17310 ENOG4105D01 (LipO)protein AW20_RS17315 ENOG4105C3K feS assembly ATPase SufC AW20_RS17320 ENOG4105JRK feS assembly protein SufD AW20_RS17325 ENOG4105C9B Cysteine desulfurase AW20_RS17330 ENOG4108UNV SUF system FeS assembly protein, NifU family AW20_RS17335 ENOG4105DIW FeS assembly protein SUFB AW20_RS17360 ENOG4107R8B 5'-nucleotidase AW20_RS17365 ENOG4105KZD Domain of unknown function (DUF1805) AW20_RS17375 ENOG4105FAA peptidase M23 AW20_RS17400 ENOG41090T1 Membrane AW20_RS17405 ENOG4107TXC Transcriptional regulator AW20_RS17410 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AW20_RS17415 ENOG4105MMD transcriptional regulator AW20_RS17435 ENOG4105CBT Fructose-1,6-bisphosphatase AW20_RS17450 ENOG4105D4U had-superfamily hydrolase, subfamily iia AW20_RS17455 ENOG4105DYS nad(p)h dehydrogenase (quinone) AW20_RS17470 ENOG4108W5N phosphatidylglycerophosphatase a AW20_RS17485 ENOG41083MR nifu domain-containing protein AW20_RS17530 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AW20_RS17535 ENOG4105C4B ABC transporter, permease AW20_RS17540 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW20_RS17565 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AW20_RS17585 ENOG4105EWC Purine nucleoside phosphorylase AW20_RS17615 ENOG4105CEP NADH dehydrogenase AW20_RS17630 ENOG41069ER domain protein AW20_RS17650 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW20_RS17670 ENOG4105KA0 thioesterase Superfamily protein AW20_RS17690 ENOG4107R3E Citrate transporter AW20_RS17700 ENOG4105Y38 Kinase-associated protein B AW20_RS17715 ENOG4105C87 Aminotransferase class I and II AW20_RS17725 ENOG4108MUZ hydrolase AW20_RS17730 ENOG4105C5I Dehydrogenase AW20_RS17735 ENOG4108ZB6 transcriptional regulator AsnC family AW20_RS17740 ENOG4105CHM Aminotransferase AW20_RS17750 ENOG4105WG9 Conserved Protein AW20_RS17760 ENOG4107QYV phosphohexose isomerase AW20_RS17770 ENOG4107PBV potassium channel AW20_RS17775 ENOG4105KT7 mgtC SapB transporter AW20_RS17810 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AW20_RS17925 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AW20_RS17950 ENOG4105VEQ Cold shock protein AW20_RS17960 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AW20_RS17965 ENOG4105E4F Isochorismate synthase AW20_RS17970 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AW20_RS17975 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AW20_RS17980 ENOG4108IPT Naphthoate synthase AW20_RS17990 ENOG4105DTQ mandelate racemase muconate lactonizing AW20_RS18020 ENOG41069H0 dihydroorotase EC 3.5.2.3 AW20_RS18045 ENOG4105C6Z Gluconate AW20_RS18095 ENOG41086D8 Transcriptional regulator AW20_RS18100 ENOG4105C19 ABC transporter AW20_RS18115 ENOG4107ZTW SNARE associated Golgi AW20_RS18150 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AW20_RS18155 ENOG4108UGV hypoxanthine phosphoribosyltransferase AW20_RS18180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS18185 ENOG4105BZU Histidine kinase AW20_RS18220 ENOG41087YS Phage shock protein A AW20_RS18265 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AW20_RS18270 ENOG4105C4M (Ubiquinol oxidase) subunit I AW20_RS18275 ENOG4108V2W Carbonate dehydratase AW20_RS18330 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AW20_RS18340 ENOG4105D2X ABC transporter substrate-binding protein AW20_RS18360 ENOG4107S9D Alpha beta hydrolase AW20_RS18365 ENOG4105BZU Histidine kinase AW20_RS18370 ENOG4105BZU Histidine kinase AW20_RS18375 ENOG4105EGD dinuclear metal center protein, YbgI family AW20_RS18430 ENOG4108RIR Molybdenum cofactor biosynthesis protein AW20_RS18440 ENOG4105BZF Glycosyl transferase (Group 1 AW20_RS18445 ENOG4105YVM Phosphoesterase, PA-phosphatase related AW20_RS18450 ENOG4108Z0R Transferase AW20_RS18455 ENOG4105E8V Alpha Beta Hydrolase Fold protein AW20_RS18485 ENOG4105DA5 (ABC) transporter AW20_RS18495 ENOG4105N5T Radical SAM Protein AW20_RS18515 ENOG4105C19 ABC transporter AW20_RS18530 ENOG4105NCW Trka-c domain protein AW20_RS18535 ENOG4107S91 Sodium hydrogen exchanger AW20_RS18540 ENOG410605W Major Facilitator AW20_RS18575 ENOG4108B31 Spore germination protein AW20_RS18585 ENOG4105DWV Homoserine O-trans-acetylase AW20_RS18595 ENOG41085GJ domain protein AW20_RS18620 ENOG4105D06 uba thif-type nad fad binding protein AW20_RS18630 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW20_RS18635 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AW20_RS18640 ENOG4108ZAF Molybdopterin AW20_RS18655 ENOG4105CSC Glucose uptake protein AW20_RS18660 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AW20_RS18665 ENOG4108VJ1 Transcriptional regulator (CarD family AW20_RS18700 ENOG4105CBX hi0933 family AW20_RS18715 ENOG4105YW5 deoR family transcriptional regulator AW20_RS18740 ENOG4108IUM Glycogen debranching enzyme AW20_RS18745 ENOG4108V15 phosphotransferase enzyme family AW20_RS18760 ENOG4105C8F Beta-lactamase domain protein AW20_RS18790 ENOG4108VDD TRNA binding domain protein AW20_RS18835 ENOG4105C88 aminopeptidase AW20_RS18860 ENOG4105ETE Transcriptional regulator (LacI family AW20_RS18890 ENOG4105EP9 oxidoreductase AW20_RS18895 ENOG4107SNB ankyrin repeat protein YahD AW20_RS18905 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_RS18915 ENOG4105DGU Histone deacetylase AW20_RS18920 ENOG4105W87 Cbs domain AW20_RS18925 ENOG4105F1V Acetoin utilization protein AW20_RS18940 ENOG4105EMN RNA polymerase sigma factor AW20_RS18970 ENOG4105C28 cystathionine AW20_RS18990 ENOG4106KR7 LysR family Transcriptional regulator AW20_RS19015 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AW20_RS19025 ENOG4105EFZ amidohydrolase AW20_RS19040 ENOG4105KBJ sporulation protein ytfj AW20_RS19045 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AW20_RS19055 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AW20_RS19075 ENOG4108JYZ YitT family AW20_RS19115 ENOG4107YZX Universal stress protein AW20_RS19135 ENOG4105VZ8 Transcriptional regulator AW20_RS19145 ENOG41082W1 Cupin 2, conserved barrel domain protein AW20_RS19150 ENOG4105Z7P Acetyltransferase (GNAT) family AW20_RS19185 ENOG4105DC7 peptidase M24 AW20_RS19220 ENOG4105SFS phosphoesterase RecJ domain protein AW20_RS19230 ENOG4105VV2 AW20_RS19235 ENOG4105C0B DNA polymerase III (alpha subunit) AW20_RS19240 ENOG4105C6K Malic enzyme AW20_RS19245 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AW20_RS19270 ENOG4105FS0 cytoplasmic membrane protein AW20_RS19275 ENOG4108REF Sporulation integral membrane protein ytvi AW20_RS19290 ENOG4105BZN citrate synthase AW20_RS19295 ENOG4108HMX isocitrate dehydrogenase (NADP) AW20_RS19315 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_RS19320 ENOG4105BZU Histidine kinase AW20_RS19325 ENOG4105C2M dna polymerase I AW20_RS19340 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AW20_RS19345 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AW20_RS19370 ENOG4108TDW sporulation protein YtxC AW20_RS19375 ENOG4105C22 threonyL-tRNA synthetase AW20_RS19400 ENOG4105CN9 Peptidase m42 family protein AW20_RS19405 ENOG4108JGH Tetr family transcriptional regulator AW20_RS19410 ENOG4105CW7 secretion protein, HlyD family AW20_RS19415 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_RS19450 ENOG4108RWN rrna methyltransferase AW20_RS19515 ENOG4105FE9 pseudouridine synthase AW20_RS19525 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AW20_RS19535 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AW20_RS19550 ENOG4105E0A ABC, transporter AW20_RS19555 ENOG4105KFN sortase, SrtB family AW20_RS19570 ENOG4105DR4 Methyltransferase AW20_RS19585 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW20_RS19630 ENOG4105S6R Iron-hydroxamate transporter permease subunit AW20_RS19635 ENOG4105J76 Periplasmic binding protein AW20_RS19645 ENOG4105CEY Amp-dependent synthetase and ligase AW20_RS19650 ENOG4107Z3H Transcriptional regulator, TetR family AW20_RS19655 ENOG41060WC Enoyl-CoA hydratase AW20_RS19660 ENOG4105BZJ Electron transfer flavoprotein AW20_RS19665 ENOG4105C10 Electron transfer flavoprotein AW20_RS19670 ENOG4105K63 Thioredoxin AW20_RS19685 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AW20_RS19695 ENOG4105E33 succinate dehydrogenase AW20_RS19705 ENOG4108VXD carboxy-peptidase AW20_RS19710 ENOG4105E14 MotA TolQ exbB proton channel AW20_RS19720 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AW20_RS19730 ENOG4105RHA ABC transporter, permease AW20_RS19735 ENOG4108Z40 Transcriptional regulator AW20_RS19740 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AW20_RS19750 ENOG4108JCI Transcriptional regulator AW20_RS19755 ENOG41067S9 phage shock protein C, PspC AW20_RS19770 ENOG4105DY9 regulatoR AW20_RS19780 ENOG4108JQ7 (ABC) transporter AW20_RS19795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW20_RS19800 ENOG4105DEF Extracellular solute-binding protein, family 5 AW20_RS19805 ENOG4105DZC cytosine deaminase AW20_RS19810 ENOG4105DZC cytosine deaminase AW20_RS19825 ENOG4105PFC Transcriptional regulator AW20_RS19840 ENOG4105KBX Transcriptional regulator, TetR family AW20_RS19850 ENOG4108PCX Major Facilitator AW20_RS19860 ENOG4108XJQ germination protein AW20_RS19875 ENOG4105M59 Phosphodiesterase, mj0936 family AW20_RS19895 ENOG4108QCI YvbH-like oligomerisation region AW20_RS19925 ENOG4108IUQ atp-dependent protease AW20_RS19945 ENOG4105K56 Transcriptional regulator AW20_RS19970 ENOG4105D52 delta-aminolevulinic acid dehydratase AW20_RS19980 ENOG41068KH stage VI sporulation protein D AW20_RS19990 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AW20_RS19995 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AW20_RS20015 ENOG4105DFF Rod shape-determining protein mreb AW20_RS20035 ENOG4107QMS site-determining protein AW20_RS20050 ENOG4105C03 ribonuclease AW20_RS20060 ENOG4105X36 (ribosomal) protein AW20_RS20075 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AW20_RS20110 ENOG4105CQC Prephenate dehydratase AW20_RS20115 ENOG4108RPX mosc domain containing protein AW20_RS20130 ENOG4108IYU L-aspartate oxidase AW20_RS20135 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AW20_RS20160 ENOG41082BM Transcriptional regulator, arsr family AW20_RS20165 ENOG4108IPJ Membrane AW20_RS20170 ENOG4108IPJ Membrane AW20_RS20180 ENOG4108HUF Transporter AW20_RS20195 ENOG41061AI Protein of unknown function (DUF2905) AW20_RS20210 ENOG4105VIE preprotein translocase, subunit YajC AW20_RS20220 ENOG4108QG2 Membrane AW20_RS20225 ENOG4105CKP Polysaccharide Biosynthesis Protein AW20_RS20235 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AW20_RS20240 ENOG41076HS cation diffusion facilitator family transporter AW20_RS20245 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AW20_RS20255 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AW20_RS20280 ENOG4105CUZ uba thif-type nad fad binding protein AW20_RS20300 ENOG4105C3J Cysteine desulfurase AW20_RS20305 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AW20_RS20315 ENOG4105C7H Helicase, RecD TraA family AW20_RS20320 ENOG41060CR AW20_RS20335 ENOG4105C02 permease AW20_RS20345 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW20_RS20365 ENOG4105HHA aminodeoxychorismate lyase AW20_RS20375 ENOG4105XYU peptidase (U32 family) AW20_RS20380 ENOG4105CFP Peptidase U32 AW20_RS20395 ENOG4107XRG penicillin-binding protein AW20_RS20425 ENOG4105C28 cystathionine AW20_RS20430 ENOG4105C0A alcohol dehydrogenase AW20_RS20440 ENOG4108V5C ABC transporter AW20_RS20445 ENOG4105S6R Iron-hydroxamate transporter permease subunit AW20_RS20500 ENOG4105MIR Phenylalanine 4-monooxygenase AW20_RS20505 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AW20_RS20540 ENOG4108MUZ hydrolase AW20_RS20550 ENOG4105G6Z alkaline phosphatase AW20_RS20565 ENOG4108TVJ Nitroreductase AW20_RS20585 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_RS20600 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AW20_RS20605 ENOG4105CQW ribosome biogenesis GTPase YqeH AW20_RS20615 ENOG410812S Rna-binding protein AW20_RS20625 ENOG4108WF2 Metal Dependent Phosphohydrolase AW20_RS20635 ENOG4105DXX methyltransferase AW20_RS20645 ENOG4105KQC Competence protein AW20_RS20650 ENOG4108UK2 deaminase AW20_RS20655 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AW20_RS20665 ENOG4105TQK DNA polymerase iii, delta' subunit AW20_RS20690 ENOG4105KVH Transcriptional regulator AW20_RS20695 ENOG4105CSA Coproporphyrinogen iii oxidase AW20_RS20725 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AW20_RS20730 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AW20_RS20740 ENOG4105KTH gatB Yqey AW20_RS20745 ENOG41068P3 sporulation protein YqfC AW20_RS20760 ENOG4105C9A Phoh family AW20_RS20765 ENOG4105CTJ Metal Dependent Phosphohydrolase AW20_RS20775 ENOG4107YR5 Diacylglycerol kinase AW20_RS20780 ENOG4105KG3 cytidine deaminase AW20_RS20785 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AW20_RS20820 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AW20_RS20840 ENOG4105EGD dinuclear metal center protein, YbgI family AW20_RS20865 ENOG41069ZM Protein of unknown function (DUF2624) AW20_RS20870 ENOG4108JYZ YitT family AW20_RS20875 ENOG4105FDK ABC transporter AW20_RS20885 ENOG4105N80 Ferric uptake regulator, Fur family AW20_RS20910 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW20_RS20920 ENOG4107RF6 penicillin-binding protein AW20_RS20925 ENOG4105PWN phosphate abc transporter AW20_RS20930 ENOG4105C8U phosphate abc transporter AW20_RS20935 ENOG4105E2Z phosphate ABC transporter (Permease AW20_RS20945 ENOG4108UTW Plays a role in the regulation of phosphate uptake AW20_RS20960 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AW20_RS20970 ENOG4105DKQ ROK family AW20_RS20980 ENOG4105C5X domain protein AW20_RS21005 ENOG4105C28 cystathionine AW20_RS21010 ENOG4105C28 cystathionine AW20_RS21025 ENOG4105C3R Methionine synthase AW20_RS21030 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AW20_RS21150 ENOG4105C0D helicase AW20_RS21180 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW20_RS21185 ENOG4105CJ1 ABC, transporter AW20_RS21225 ENOG41080TC multidrug resistance protein AW20_RS21245 ENOG4105WZW rhodanese family AW20_RS21250 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AW20_RS21270 ENOG4107YBY Hydrolase AW20_RS21280 ENOG4105CBJ Metal-dependent enzyme AW20_RS21295 ENOG4105DC7 peptidase M24 AW20_RS21320 ENOG4105CD2 stage iii sporulation protein aa AW20_RS21325 ENOG4105KR5 Stage iii sporulation protein AW20_RS21330 ENOG4108CQH stage III sporulation protein AC AW20_RS21335 ENOG4105KQ4 Stage iii sporulation protein ad AW20_RS21345 ENOG410644B Stage III sporulation protein af AW20_RS21370 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AW20_RS21375 ENOG4108ZSR alkaline shock protein AW20_RS21400 ENOG4105CTB Polyprenyl synthetase AW20_RS21410 ENOG4105DX0 Hemolysin A AW20_RS21420 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AW20_RS21425 ENOG4105S1Z Stage IV sporulation protein B AW20_RS21430 ENOG4107QQR Sporulation AW20_RS21445 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AW20_RS21455 ENOG4108JUB Transcriptional regulator AW20_RS21470 ENOG4107RDP Dehydrogenase AW20_RS21490 ENOG4105CPP Dehydrogenase, E1 component AW20_RS21495 ENOG4105C7S Dehydrogenase AW20_RS21515 ENOG4105G7B Protein of unknown function (DUF2992) AW20_RS21530 ENOG4108HW3 (ABC) transporter AW20_RS21535 ENOG4105E5Q amino acid AbC transporter AW20_RS21540 ENOG4105CDA abc transporter atp-binding protein AW20_RS21545 ENOG4108QEG Membrane AW20_RS21550 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AW20_RS21565 ENOG4105D9U N-acetyltransferase AW20_RS21570 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AW20_RS21580 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW20_RS21605 ENOG4105EJQ L-serine dehydratase AW20_RS21625 ENOG4108IXY short-chain dehydrogenase reductase AW20_RS21640 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AW20_RS21680 ENOG4105CGH 5'-nucleotidase AW20_RS21685 ENOG4105DFD Na H antiporter AW20_RS21695 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW20_RS21710 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW20_RS21715 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW20_RS21740 ENOG4108R6K riboflavin synthase, subunit alpha AW20_RS21745 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AW20_RS21765 ENOG4108YM7 Gcn5-related n-acetyltransferase AW20_RS21770 ENOG4105ETE Transcriptional regulator (LacI family AW20_RS21780 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AW20_RS21800 ENOG4105RHY Pfam:UPF0157 AW20_RS21810 ENOG4105CPC Aldo Keto reductase AW20_RS21830 ENOG4105MZ9 stage II sporulation protein m AW20_RS21835 ENOG4105I3K Ferric uptake regulator, Fur family AW20_RS21845 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW20_RS21870 ENOG4105D7N magnesium and cobalt transport protein CorA AW20_RS21905 ENOG4105DVE abc transporter atp-binding protein AW20_RS21910 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW20_RS21915 ENOG4105DZ1 carboxypeptidase AW20_RS21920 ENOG41082AN stage II sporulation protein AW20_RS21930 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_RS21935 ENOG4105C8J )-transporter AW20_RS21955 ENOG41090VF Stage v sporulation protein ac AW20_RS21960 ENOG4105CZ3 stage V sporulation protein ad AW20_RS21970 ENOG4105G6R Stage v sporulation protein ae AW20_RS21980 ENOG4105J7I hydrolase AW20_RS21985 ENOG4105PTM secreted protein AW20_RS21990 ENOG4107ZE5 PPIases accelerate the folding of proteins AW20_RS22035 ENOG4105CE4 GlcNAc 6-P deacetylase AW20_RS22055 ENOG4105CID antiterminator AW20_RS22090 ENOG4106TD9 Diguanylate cyclase AW20_RS22110 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AW20_RS22135 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AW20_RS22155 ENOG4105DTD Dehydrogenase AW20_RS22160 ENOG4105K7K Transcriptional regulator AW20_RS22200 ENOG4105CHU acetyl-coa acetyltransferase AW20_RS22245 ENOG4105CG3 alpha amylase, catalytic region AW20_RS22255 ENOG4107FKK extracellular solute-binding protein family 1 AW20_RS22265 ENOG4105EG2 ABC transporter, permease AW20_RS22270 ENOG4105FKQ transcriptional regulator AW20_RS22275 ENOG4105CHM Aminotransferase AW20_RS22285 ENOG4108HGU Histidine kinase AW20_RS22350 ENOG4105UIN AW20_RS22360 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AW20_RS22375 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AW20_RS22380 ENOG4105EPM Diguanylate phosphodiesterase AW20_RS22395 ENOG4107IN1 Protein of unknown function (DUF1797) AW20_RS22405 ENOG4108XRC Protein of unknown function (DUF458) AW20_RS22440 ENOG4107ZYR domain protein AW20_RS22445 ENOG4105CN5 Metallo-Beta-Lactamase AW20_RS22455 ENOG4108X4Q Hydrolase AW20_RS22460 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AW20_RS22475 ENOG4105CPP Dehydrogenase, E1 component AW20_RS22480 ENOG4105C7S Dehydrogenase AW20_RS22525 ENOG4105CXN decarboxylase AW20_RS22545 ENOG4105ECY inositol monophosphatase AW20_RS22555 ENOG4105CI3 gtp-binding protein typa AW20_RS22560 ENOG4105QA2 AW20_RS22580 ENOG4108IAB Phoh family AW20_RS22595 ENOG4105CNI cell division protein FtsW AW20_RS22600 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AW20_RS22650 ENOG4106UY4 Inherit from COG: Scp-like extracellular AW20_RS22665 ENOG4107TB6 phosphoglycerate mutase AW20_RS22685 ENOG4106H78 methyltransferase AW20_RS22695 ENOG4105H20 Sporulation integral membrane protein YlbJ AW20_RS22700 ENOG4105D78 K07001 NTE family protein AW20_RS22705 ENOG41063PX domain protein AW20_RS22715 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AW20_RS22740 ENOG4108IMY Transcriptional regulator AW20_RS22795 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_RS22900 ENOG4105CAR Terminase, large subunit AW20_RS22995 ENOG4105XSJ toxin secretion phage lysis holin AW20_RS23045 ENOG4105KNH Nucleic acid-binding protein AW20_RS23080 ENOG41068DC Essential cell division protein (By similarity) AW20_RS23085 ENOG4105CJN penicillin-binding protein AW20_RS23090 ENOG4105CJN penicillin-binding protein AW20_RS23095 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AW20_RS23110 ENOG4105CNI cell division protein FtsW AW20_RS23120 ENOG4105D4A Cell wall formation (By similarity) AW20_RS23125 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AW20_RS23130 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AW20_RS23135 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AW20_RS23145 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW20_RS23155 ENOG4105WR5 sporulation protein, YlmC YmxH family AW20_RS23160 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AW20_RS23165 ENOG4105DFA alanine racemase domain protein AW20_RS23175 ENOG41067XK integral membrane protein AW20_RS23180 ENOG4105DBK s4 domain protein AW20_RS23205 ENOG4105C34 Pseudouridine synthase AW20_RS23285 ENOG4105DC7 peptidase M24 AW20_RS23300 ENOG4105DSJ YicC domain protein AW20_RS23320 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AW20_RS23325 ENOG4105C25 Primosomal protein n' AW20_RS23330 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AW20_RS23340 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AW20_RS23350 ENOG4108ZF3 Phosphatase AW20_RS23355 ENOG4105D9P serine threonine protein kinase AW20_RS23360 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AW20_RS23365 ENOG4105DJV ribulose-phosphate 3-epimerase AW20_RS23370 ENOG4105FJ0 thiamine AW20_RS23385 ENOG4108ZAA Alkaline-shock protein AW20_RS23390 ENOG4105DP4 dak2 domain fusion protein ylov AW20_RS23395 ENOG4105CB5 ATP-dependent DNA helicase recG AW20_RS23410 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AW20_RS23415 ENOG4105CHR reductase AW20_RS23430 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AW20_RS23435 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AW20_RS23455 ENOG4105VB6 UPF0109 protein AW20_RS23480 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AW20_RS23495 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AW20_RS23505 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AW20_RS23515 ENOG4108HE4 integrase family AW20_RS23555 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AW20_RS23560 ENOG4105KNE Phosphatidate cytidylyltransferase AW20_RS23570 ENOG4105DZP Membrane-associated zinc metalloprotease AW20_RS23580 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AW20_RS23590 ENOG4105CHV Transcription elongation factor NusA AW20_RS23595 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AW20_RS23600 ENOG4105VHM ribosomal protein AW20_RS23610 ENOG4105W7A Protein of unknown function (DUF503) AW20_RS23620 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AW20_RS23625 ENOG4105DTN riboflavin biosynthesis protein ribF AW20_RS23645 ENOG4105C1V Peptidase, M16 AW20_RS23655 ENOG4105E35 Dipicolinate synthase subunit A AW20_RS23660 ENOG4108S0H Dipicolinic acid synthetase, b subunit AW20_RS23665 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AW20_RS23675 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AW20_RS23690 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AW20_RS23700 ENOG4107QZI cell division protein FtsK AW20_RS23705 ENOG4105FDP GntR family transcriptional regulator AW20_RS23710 ENOG4105DIH basic membrane AW20_RS23715 ENOG4108JQ9 ABC transporter AW20_RS23745 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AW20_RS23750 ENOG4105XZV Protein of unknown function (DUF3243) AW20_RS23765 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AW20_RS23790 ENOG4105D48 metallophosphoesterase AW20_RS23795 ENOG4105MCT stage V sporulation protein S AW20_RS23800 ENOG4108IGT Dipeptidase AW20_RS23805 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AW20_RS23810 ENOG4105DQU oxidoreductase, subunit beta AW20_RS23815 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AW20_RS23840 ENOG4105DA5 (ABC) transporter AW20_RS23865 ENOG4107QHE Choloylglycine hydrolase AW20_RS23875 ENOG410890F Dynamin family AW20_RS23880 ENOG4105E0M Sulfatase AW20_RS23885 ENOG4107R6R udp-galactopyranose mutase AW20_RS23890 ENOG4105F0V Cell wall hydrolase AW20_RS23910 ENOG4107YEI lmbE family AW20_RS23915 ENOG4107TTQ Alpha beta hydrolase fold AW20_RS23930 ENOG41067MG lrgb family AW20_RS23950 ENOG4105BZU Histidine kinase AW20_RS23955 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_RS23985 ENOG4105D03 DNA-3-methyladenine glycosylase II AW20_RS23990 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AW20_RS24000 ENOG4105CGK Exodeoxyribonuclease III AW20_RS24025 ENOG4105E0A ABC, transporter AW20_RS24030 ENOG4105NIV Esterase AW20_RS24040 ENOG4105VPX protein, conserved in bacteria AW20_RS24045 ENOG410681U heavy metal transport detoxification protein AW20_RS24050 ENOG4105C59 p-type ATPase AW20_RS24055 ENOG4105K70 DNA-binding protein AW20_RS24060 ENOG4105TMB Formate nitrite transporter AW20_RS24075 ENOG4105C85 amino acid AW20_RS24090 ENOG4108SJC Membrane AW20_RS24100 ENOG4105E98 transcriptional regulator DeoR family AW20_RS24105 ENOG4105DE4 1-phosphofructokinase AW20_RS24110 ENOG4105DM4 PTS System AW20_RS24115 ENOG41069ER domain protein AW20_RS24145 ENOG4106F1P AAA ATPase, central domain protein AW20_RS24150 ENOG4105EN6 Membrane AW20_RS24160 ENOG4105CXI aluminum resistance protein AW20_RS24165 ENOG4105KV4 Transcriptional regulator AW20_RS24170 ENOG4105C5F glutamine synthetase AW20_RS24275 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AW20_RS24480 ENOG4105XSJ toxin secretion phage lysis holin AW20_RS24485 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AW20_RS24520 ENOG4105K7K Transcriptional regulator AW20_RS24540 ENOG4108SVB resolvase AW20_RS24565 ENOG4105D5T phosphonate abc transporter AW20_RS24585 ENOG4105D7V transposase AW20_RS24605 ENOG4105BZ1 (ABC) transporter AW20_RS24610 ENOG4105BZ1 (ABC) transporter AW20_RS24625 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW20_RS24650 ENOG41067MG lrgb family AW20_RS24655 ENOG4105VAW lrga family AW20_RS24660 ENOG4107RSM transcriptional regulator AW20_RS24670 ENOG4107QIV Cytochrome c biogenesis protein AW20_RS24730 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AW20_RS24755 ENOG4108903 Formimidoylglutamase AW20_RS24760 ENOG4108VJ1 Transcriptional regulator (CarD family AW20_RS24765 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AW20_RS24770 ENOG4105CBC glutamate synthase AW20_RS24775 ENOG4105CK7 Sodium proline symporter AW20_RS24780 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AW20_RS24785 ENOG4105FBA Phospholipase Carboxylesterase AW20_RS24790 ENOG4105BZU Histidine kinase AW20_RS24800 ENOG4107AYK membrAne AW20_RS24845 ENOG4105CEY Amp-dependent synthetase and ligase AW20_RS24850 ENOG4107ZYJ bioY protein AW20_RS24855 ENOG4107F3J Amp-dependent synthetase and ligase AW20_RS24875 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW20_RS24915 ENOG4108I0Z Aconitate hydratase AW20_RS24920 ENOG4108JJA ABC, transporter AW20_RS24930 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW20_RS24935 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AW20_RS24965 ENOG4105W8X HesB YadR YfhF-family protein AW20_RS24970 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AW20_RS24975 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AW20_RS24985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS24990 ENOG4105C0H protease AW20_RS24995 ENOG4105K4P CoA-binding domain protein AW20_RS25005 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW20_RS25015 ENOG4105D9R oxidoreductase AW20_RS25025 ENOG4105CIG ABC transporter AW20_RS25050 ENOG4105EMN RNA polymerase sigma factor AW20_RS25060 ENOG4108KGH TRANSCRIPTIONal AW20_RS25065 ENOG4107QJT sodium dicarboxylate symporter AW20_RS25125 ENOG4105E1K spore germination protein AW20_RS25135 ENOG4108JB9 formate dehydrogenase AW20_RS25145 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AW20_RS25150 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AW20_RS25160 ENOG4105TMB Formate nitrite transporter AW20_RS25165 ENOG4105D06 uba thif-type nad fad binding protein AW20_RS25170 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW20_RS25175 ENOG4108ZAF Molybdopterin AW20_RS25185 ENOG4105D1F ATP-binding protein AW20_RS25200 ENOG410696E Membrane AW20_RS25205 ENOG4105FR1 rard protein AW20_RS25215 ENOG4105EWU Squalene--hopene cyclase AW20_RS25225 ENOG4105CHR reductase AW20_RS25230 ENOG4105C26 Dehydrogenase AW20_RS25240 ENOG4108IA2 Sodium pantothenate symporter AW20_RS25255 ENOG4106IQC argininosuccinate lyase AW20_RS25265 ENOG410904N short-chain dehydrogenase reductase AW20_RS25285 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AW20_RS25305 ENOG4105VEQ Cold shock protein AW20_RS25325 ENOG4108R1P AW20_RS25335 ENOG41073R8 VanW family AW20_RS25340 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_RS25350 ENOG4105KT7 mgtC SapB transporter AW20_RS25360 ENOG4105E39 Enoyl-CoA hydratase AW20_RS25365 ENOG4105K64 Glycosyl transferase, family 2 AW20_RS25375 ENOG4108UT6 Transferase hexapeptide repeat containing protein AW20_RS25395 ENOG4105CQB FAD linked oxidase domain protein AW20_RS25400 ENOG4105C09 Bile acid AW20_RS25410 ENOG4105RHY Pfam:UPF0157 AW20_RS25435 ENOG4105CIS alcohol dehydrogenase AW20_RS25440 ENOG41082BM Transcriptional regulator, arsr family AW20_RS25465 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AW20_RS25495 ENOG4108A04 Beta-lactamase AW20_RS25500 ENOG4105DPN Oligoendopeptidase f AW20_RS25510 ENOG4105E5K Alpha-amylase AW20_RS25520 ENOG4105C98 muts2 protein AW20_RS25540 ENOG4107V2S Transcriptional regulator AW20_RS25550 ENOG4107CUJ Protein of unknown function (DUF2690) AW20_RS25570 ENOG4107ZY0 Phenazine biosynthesis-like protein AW20_RS25575 ENOG4105NX3 Membrane AW20_RS25580 ENOG4105DQ5 transport system permease protein AW20_RS25585 ENOG4105EHG Permease protein AW20_RS25595 ENOG4108MES Periplasmic binding protein AW20_RS25615 ENOG4107R3E Citrate transporter AW20_RS25625 ENOG4108TN2 lmbE family AW20_RS25700 ENOG4105H3G oxidoreductase AW20_RS25735 ENOG4107YXZ hydrolase, family 25 AW20_RS25750 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AW20_RS25775 ENOG4105KAF membrAne AW20_RS25845 ENOG4105KVH Transcriptional regulator AW20_RS25865 ENOG4105CHR reductase AW20_RS25875 ENOG4105JAB phenazine biosynthesis protein, phzf family AW20_RS25910 ENOG4105KVH Transcriptional regulator AW20_RS25915 ENOG4105KVH Transcriptional regulator AW20_RS25920 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AW20_RS25930 ENOG4108TZY GntR Family Transcriptional Regulator AW20_RS25935 ENOG4105KVH Transcriptional regulator AW20_RS25970 ENOG4105C44 Serine transporter AW20_RS25975 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AW20_RS25990 ENOG4105F27 Major Facilitator AW20_RS25995 ENOG4105CV8 reductase AW20_RS26015 ENOG4105D4Y metalloprotease AW20_RS26020 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AW20_RS26040 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AW20_RS26045 ENOG4105CIS alcohol dehydrogenase AW20_RS26050 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AW20_RS26055 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AW20_RS26070 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AW20_RS26075 ENOG4105C6Z Gluconate AW20_RS26080 ENOG4105CMG Carbohydrate kinase AW20_RS26085 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AW20_RS26090 ENOG4105XDF Protein of unknown function (DUF1272) AW20_RS26095 ENOG4105DDN Pentapeptide repeat-containing protein AW20_RS26110 ENOG4105C37 (CBS) domain AW20_RS26140 ENOG4105EV4 Multidrug resistance protein mdtH AW20_RS26150 ENOG4105DMQ Methyltransferase AW20_RS26175 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AW20_RS26185 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW20_RS26200 ENOG4108UW5 maltose o-acetyltransferase AW20_RS26205 ENOG4106UW1 Major Facilitator superfamily AW20_RS26210 ENOG4105DKQ ROK family AW20_RS26215 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_RS26275 ENOG4105CJ1 ABC, transporter AW20_RS26285 ENOG4108PSK reductase AW20_RS26305 ENOG4108RCM Nitroreductase AW20_RS26310 ENOG4105KVH Transcriptional regulator AW20_RS26325 ENOG4105CUT histidyl-tRNA synthetase AW20_RS26330 ENOG4108Z66 YbaK ebsC protein AW20_RS26340 ENOG41067QW Transcriptional regulator AW20_RS26355 ENOG4108K8S endonuclease I AW20_RS26380 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AW20_RS26385 ENOG4108JJB ABC transporter AW20_RS26415 ENOG4105DYS nad(p)h dehydrogenase (quinone) AW20_RS26425 ENOG4105CRW Short chain fatty acid transporter AW20_RS26440 ENOG4105KBX Transcriptional regulator, TetR family AW20_RS26445 ENOG4105KPY Small multidrug resistance protein AW20_RS26450 ENOG4105RXJ AW20_RS26460 ENOG41069JR AW20_RS26465 ENOG4105DA5 (ABC) transporter AW20_RS26485 ENOG4105CZM Major Facilitator AW20_RS26490 ENOG4107MII Sugar-specific transcriptional regulator TrmB AW20_RS26500 ENOG4108ISG Major Facilitator AW20_RS26555 ENOG410874W AraC family transcriptional regulator AW20_RS26565 ENOG41082W1 Cupin 2, conserved barrel domain protein AW20_RS26580 ENOG4108AEY RNA polymerase sigma factor AW20_RS26600 ENOG4108JQ1 Dehydrogenase AW20_RS26615 ENOG4105DVH amino acid AW20_RS26625 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AW20_RS26640 ENOG4108JPW Aminotransferase AW20_RS26655 ENOG4105EJQ L-serine dehydratase AW20_RS26660 ENOG4105C44 Serine transporter AW20_RS26675 ENOG4108JGH Tetr family transcriptional regulator AW20_RS26680 ENOG4105EQ0 Major Facilitator superfamily AW20_RS26695 ENOG4107QJQ Mate efflux family protein AW20_RS26725 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW20_RS26760 ENOG4105TRI Hydrolase AW20_RS26795 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AW20_RS26805 ENOG4106P55 Transcriptional regulator AW20_RS26815 ENOG4107QR9 Iron-sulfur cluster binding protein AW20_RS26820 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AW20_RS26825 ENOG4105DJB Major Facilitator Superfamily AW20_RS26830 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AW20_RS26845 ENOG4108U05 Transcriptional regulator AW20_RS26860 ENOG4105BZU Histidine kinase AW20_RS26880 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AW20_RS26885 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AW20_RS26900 ENOG4105JQZ Methyltransferase AW20_RS26905 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW20_RS26915 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AW20_RS26920 ENOG4108NNI Beta-lactamase domain-containing protein AW20_RS26935 ENOG4105VZ8 Transcriptional regulator AW20_RS26960 ENOG4105K6H D-cysteine desulfhydrase AW20_RS26990 ENOG41062D9 Histidine kinase AW20_RS26995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW20_RS27010 ENOG4105IIP Membrane AW20_RS27020 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW20_RS27030 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AW20_RS27105 ENOG4108YXU transcriptional regulator AsnC family AW20_RS27110 ENOG4105CHR reductase AW20_RS27120 ENOG4105F7F Chaperone AW20_RS27135 ENOG41085FC arsR family transcriptional regulator AW20_RS27140 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AW20_RS27145 ENOG4105D6J arsenicaL-resistance protein AW20_RS27175 ENOG4105DIK (ABC) transporter AW20_RS27180 ENOG4105CC5 ABC transporter AW20_RS27185 ENOG4105DSE periplasmic solute binding protein AW20_RS27190 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AW20_RS27195 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AW20_RS27205 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AW20_RS27210 ENOG4108TWJ NADH dehydrogenase subunit 5 AW20_RS27225 ENOG4105CVP deoxyribo-dipyrimidine photolyase AW20_RS27230 ENOG4108606 TspO/MBR family AW20_RS27295 ENOG4105CHJ isochorismatase hydrolase AW20_RS27305 ENOG4105CH6 catalase AW20_RS27310 ENOG4105CGH 5'-nucleotidase AW20_RS27340 ENOG4105CSV Glutaminase AW20_RS27360 ENOG4108Q8B Spore germination protein AW20_RS27380 ENOG4105C6K Malic enzyme AW20_RS27390 ENOG4105II7 pyrroline-5-carboxylate reductase AW20_RS27400 ENOG4105CUB amino acid AW20_RS27405 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AW20_RS27415 ENOG4108IMY Transcriptional regulator AW20_RS27420 ENOG4105HDK L-asparaginase AW20_RS27425 ENOG4108IJ0 Aspartate ammonia-lyase AW20_RS27440 ENOG4105E2A Dehydrogenase AW20_RS27505 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AW20_RS27535 ENOG4105DWD nucleoside recognition domain protein AW20_RS27555 ENOG4105FDT acyl-CoA dehydrogenase AW20_RS27565 ENOG4108ZHR arsR family transcriptional regulator AW20_RS27570 ENOG4108ZRV stage ii sporulation protein p AW20_RS27575 ENOG4106N3A copper homeostasis protein cutc AW20_RS27585 ENOG4107258 Transcriptional regulator AW20_RS27590 ENOG4105P4J Allophanate hydrolase, subunit 1 AW20_RS27630 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AW20_RS27640 ENOG4107RF6 penicillin-binding protein AW20_RS27680 ENOG4105F1N DNA alkylation repair AW20_RS27690 ENOG4108IQI permease AW20_RS27695 ENOG4105KNA -acetyltransferase AW20_RS27700 ENOG410635A Membrane AW20_RS27780 ENOG4108XET gCN5-related N-acetyltransferase AW20_RS27810 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW20_RS27820 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW20_RS27855 ENOG4105FS7 Transcriptional regulator AW20_RS27860 ENOG4108TVJ Nitroreductase AW20_RS27870 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW20_RS27910 ENOG4105C8Y Acetylornithine aminotransferase AW20_RS27920 ENOG4105CKK Glycosyl transferase, family 2 AW20_RS27945 ENOG4105CKK Glycosyl transferase, family 2 AW20_RS27955 ENOG4105CSH Transporter AW20_RS27970 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW20_RS27995 ENOG41068WN AW20_RS28005 ENOG4108WCX response regulator AW20_RS28015 ENOG41090T1 Membrane AW20_RS28030 ENOG4105VMP Transcriptional regulator AW20_RS28040 ENOG4105G6Z alkaline phosphatase AW20_RS28045 ENOG4105ECK Fatty Acid Desaturase AW20_RS28050 ENOG4105E0Y RtcB Protein AW20_RS28060 ENOG4107258 Transcriptional regulator AW20_RS28070 ENOG4105II7 pyrroline-5-carboxylate reductase AW20_RS28075 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AW20_RS28105 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AW20_RS28125 ENOG41061GT Aldolase AW20_RS28140 ENOG4105DKT Transcriptional regulator AW20_RS28150 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AW20_RS28160 ENOG4105D4B ABC, transporter AW20_RS28185 ENOG4105EMN RNA polymerase sigma factor AW20_RS28195 ENOG41069ER domain protein AW20_RS28210 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) AW20_RS28230 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AW20_RS28235 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AW20_RS28240 ENOG4105CIH Imidazole acetol-phosphate transaminase AW20_RS28260 ENOG41082JN Transcriptional regulator AW20_RS28265 ENOG4105EYF MMPL domain protein AW20_RS28275 ENOG4105EYF MMPL domain protein AW20_RS28285 ENOG4105C5H ABC transporter AW20_RS28290 ENOG4105E0M Sulfatase AW20_RS28295 ENOG4108ZCF integral membrane protein AW20_RS28315 ENOG4107VC0 DNA alkylation repair enzyme AW20_RS28365 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AW20_RS28385 ENOG4105E09 nadh pyrophosphatase AW20_RS28410 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AW20_RS28415 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AW20_RS28420 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AW20_RS28435 ENOG4105C02 permease AW20_RS28520 ENOG4105CHM Aminotransferase AW20_RS28555 ENOG41089UC methyltransferase, type 11 AW20_RS28570 ENOG4107BMA Transglycosylase associated protein AW20_RS28590 ENOG4106K7D Major facilitator family transporter AW20_RS28595 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AW20_RS28635 ENOG4105EPR degv family AW20_RS28640 ENOG4105DPN Oligoendopeptidase f AW20_RS28680 ENOG4105BZU Histidine kinase AW20_RS28685 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AW20_RS28725 ENOG4105DTQ mandelate racemase muconate lactonizing AW20_RS28740 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AW20_RS28745 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AW20_RS28760 ENOG4107T5V SNARE associated Golgi AW20_RS28800 ENOG41080HI glycine oxidase AW20_RS28805 ENOG4105CTU Proline racemase AW20_RS28810 ENOG4105CTU Proline racemase AW20_RS28815 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AW20_RS28820 ENOG4105C26 Dehydrogenase AW20_RS28905 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AW20_RS29655 ENOG4105CMT Dihydroxyacetone kinase AW20_RS29675 ENOG4105PKS Excinuclease abc c subunit domain protein AW20_RS30625 ENOG41090MY MarR family Transcriptional regulator AW20_RS31215 ENOG4105EYF MMPL domain protein AW20_RS31225 ENOG4105KRN Transcriptional regulator, abrb family