locus-tag	class	description
AS53_RS00035	COG4846	Membrane protein involved in cytochrome C biogenesis
AS53_RS00480	COG4846	Membrane protein involved in cytochrome C biogenesis
AS53_RS00485	COG0785	Cytochrome C biogenesis protein
AS53_RS00495	COG0583	DNA-binding transcription factor activity
AS53_RS00500	COG1380	Effector of murein hydrolase LrgA
AS53_RS00505	COG1346	cytolysis
AS53_RS00520	COG0730	response to heat
AS53_RS00530	COG5632	N-Acetylmuramoyl-L-alanine amidase
AS53_RS00530	COG3409	Peptidoglycan-binding domain 1 protein
AS53_RS00545	COG1132	(ABC) transporter
AS53_RS00550	COG1132	(ABC) transporter
AS53_RS00585	COG3639	organic phosphonate transmembrane transporter activity
AS53_RS00590	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AS53_RS00605	COG0737	Belongs to the 5'-nucleotidase family
AS53_RS00615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AS53_RS00635	COG1695	Transcriptional regulator
AS53_RS00670	COG5632	N-Acetylmuramoyl-L-alanine amidase
AS53_RS00670	COG3409	Peptidoglycan-binding domain 1 protein
AS53_RS00670	COG1388	LysM domain
AS53_RS00675	COG4824	toxin secretion phage lysis holin
AS53_RS00880	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AS53_RS00960	COG1396	sequence-specific DNA binding
AS53_RS00985	COG0174	glutamine synthetase
AS53_RS00990	COG0789	Transcriptional regulator
AS53_RS00995	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AS53_RS01005	COG2860	membrane
AS53_RS01010	COG0464	growth
AS53_RS01040	COG1388	LysM domain
AS53_RS01040	COG3584	3D domain protein
AS53_RS01045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS53_RS01045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS53_RS01045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS53_RS01050	COG1105	Belongs to the carbohydrate kinase PfkB family
AS53_RS01055	COG1349	DNA-binding transcription factor activity
AS53_RS01065	COG2322	membrane
AS53_RS01080	COG1113	amino acid transport
AS53_RS01090	COG1408	metallophosphoesterase
AS53_RS01095	COG2116	formate transmembrane transporter activity
AS53_RS01105	COG2217	Heavy metal translocating P-type atpase
AS53_RS01110	COG2608	mercury ion transmembrane transporter activity
AS53_RS01115	COG1937	Protein conserved in bacteria
AS53_RS01125	COG2819	hydrolase of the alpha beta superfamily
AS53_RS01130	COG1120	ATPase activity
AS53_RS01135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_RS01140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_RS01145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_RS01155	COG0708	Exodeoxyribonuclease III
AS53_RS01160	COG2169	Transcriptional regulator
AS53_RS01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS53_RS01170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AS53_RS01180	COG2364	Membrane
AS53_RS01195	COG2267	carboxylic ester hydrolase activity
AS53_RS01200	COG0346	lactoylglutathione lyase activity
AS53_RS01205	COG3300	MHYT domain
AS53_RS01205	COG5001	Diguanylate cyclase
AS53_RS01225	COG1346	cytolysis
AS53_RS01230	COG1380	Effector of murein hydrolase LrgA
AS53_RS01235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_RS01240	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS53_RS01240	COG0596	Alpha beta hydrolase
AS53_RS01245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS53_RS01260	COG1404	Belongs to the peptidase S8 family
AS53_RS01265	COG3773	Cell wall hydrolase
AS53_RS01270	COG0562	UDP-galactopyranose mutase
AS53_RS01275	COG1368	sulfuric ester hydrolase activity
AS53_RS01290	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AS53_RS01315	COG1131	(ABC) transporter
AS53_RS01335	COG4550	Control of competence regulator ComK, YlbF/YmcA
AS53_RS01340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS53_RS01345	COG1013	pyruvate-flavodoxin oxidoreductase activity
AS53_RS01350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AS53_RS01350	COG0674	pyruvate-flavodoxin oxidoreductase activity
AS53_RS01360	COG2359	stage V sporulation protein S
AS53_RS01365	COG1692	metallophosphoesterase
AS53_RS01390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AS53_RS01395	COG1426	Protein conserved in bacteria
AS53_RS01410	COG0300	oxidoreductase activity
AS53_RS01415	COG0612	Peptidase, M16
AS53_RS01420	COG0612	Peptidase, M16
AS53_RS01425	COG1079	Belongs to the binding-protein-dependent transport system permease family
AS53_RS01430	COG4603	Belongs to the binding-protein-dependent transport system permease family
AS53_RS01435	COG4603	Belongs to the binding-protein-dependent transport system permease family
AS53_RS01440	COG3845	ABC transporter
AS53_RS01445	COG1744	ABC transporter substrate-binding protein PnrA-like
AS53_RS01450	COG2188	Transcriptional regulator
AS53_RS01455	COG1674	ftsk spoiiie
AS53_RS01465	COG0740	serine-type endopeptidase activity
AS53_RS01470	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS53_RS01485	COG0527	aspartate kinase activity
AS53_RS01490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AS53_RS01495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AS53_RS01500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS53_RS01505	COG1873	PFAM PRC-barrel domain
AS53_RS01510	COG0612	Peptidase, M16
AS53_RS01515	COG0726	polysaccharide deacetylase
AS53_RS01530	COG0196	riboflavin kinase activity
AS53_RS01535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AS53_RS01545	COG1550	Protein conserved in bacteria
AS53_RS01555	COG1358	cellular component organization or biogenesis
AS53_RS01560	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AS53_RS01565	COG0195	Participates in both transcription termination and antitermination
AS53_RS01585	COG0750	zinc metalloprotease
AS53_RS01595	COG4589	Belongs to the CDS family
AS53_RS01600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AS53_RS01610	COG0528	UMP kinase activity
AS53_RS01640	COG4974	Belongs to the 'phage' integrase family
AS53_RS01650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS53_RS01660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AS53_RS01700	COG1837	Belongs to the UPF0109 family
AS53_RS01710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AS53_RS01720	COG0552	protein localization to endoplasmic reticulum
AS53_RS01725	COG1196	nuclear chromosome segregation
AS53_RS01735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS53_RS01740	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS01745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AS53_RS01760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AS53_RS01765	COG1461	Dihydroxyacetone kinase
AS53_RS01770	COG1302	Protein conserved in bacteria
AS53_RS01785	COG1564	THIamine pyrophosphokinase
AS53_RS01790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AS53_RS01795	COG1162	GTPase activity
AS53_RS01800	COG0515	serine threonine protein kinase
AS53_RS01800	COG2815	serine threonine protein kinase
AS53_RS01805	COG0631	protein serine/threonine phosphatase activity
AS53_RS01815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS53_RS01815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AS53_RS01825	COG0242	peptide deformylase activity
AS53_RS01830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AS53_RS01835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AS53_RS01855	COG1561	YicC-like family, N-terminal region
AS53_RS01860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AS53_RS01870	COG0006	proline dipeptidase activity
AS53_RS01885	COG3069	C4-dicarboxylate transmembrane transporter activity
AS53_RS01950	COG0564	pseudouridine synthase activity
AS53_RS01970	COG3599	regulation of cell shape
AS53_RS01975	COG2302	S4 RNA-binding domain
AS53_RS01980	COG0762	integral membrane protein
AS53_RS01990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AS53_RS01995	COG1496	oxidoreductase activity
AS53_RS02000	COG1873	PFAM PRC-barrel domain
AS53_RS02005	COG1191	sigma factor activity
AS53_RS02010	COG1191	sigma factor activity
AS53_RS02020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AS53_RS02025	COG0849	cell division
AS53_RS02030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AS53_RS02035	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AS53_RS02045	COG0772	Belongs to the SEDS family
AS53_RS02060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS53_RS02065	COG0768	penicillin binding
AS53_RS02070	COG0768	penicillin binding
AS53_RS02075	COG4839	cell division protein FtsL
AS53_RS02090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AS53_RS02105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AS53_RS02110	COG1399	metal-binding, possibly nucleic acid-binding protein
AS53_RS02160	COG4824	toxin secretion phage lysis holin
AS53_RS02255	COG4626	Terminase
AS53_RS02255	COG1802	Transcriptional regulator
AS53_RS02280	COG0582	viral genome integration into host DNA
AS53_RS02350	COG0756	dUTP diphosphatase activity
AS53_RS02360	COG1191	sigma factor activity
AS53_RS02385	COG1484	DNA-dependent DNA replication
AS53_RS02415	COG1396	sequence-specific DNA binding
AS53_RS02425	COG1396	sequence-specific DNA binding
AS53_RS02440	COG0582	viral genome integration into host DNA
AS53_RS02450	COG3480	Lon protease (S16) C-terminal proteolytic domain
AS53_RS02455	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS53_RS02460	COG3314	Sporulation integral membrane protein YlbJ
AS53_RS02470	COG0742	ribosomal rna small subunit methyltransferase
AS53_RS02485	COG3679	Belongs to the UPF0342 family
AS53_RS02490	COG0406	alpha-ribazole phosphatase activity
AS53_RS02505	COG2340	Cysteine-rich secretory protein family
AS53_RS02520	COG3336	cytochrome c oxidase
AS53_RS02555	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AS53_RS02560	COG0772	Belongs to the SEDS family
AS53_RS02570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AS53_RS02575	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AS53_RS02585	COG4896	Protein conserved in bacteria
AS53_RS02600	COG1217	gtp-binding protein TYPA
AS53_RS02610	COG0483	inositol monophosphate 1-phosphatase activity
AS53_RS02630	COG1982	Orn Lys Arg decarboxylase major
AS53_RS02675	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS53_RS02680	COG0022	dehydrogenase e1 component
AS53_RS02685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS53_RS02695	COG0242	peptide deformylase activity
AS53_RS02700	COG0561	phosphatase activity
AS53_RS02710	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS53_RS02715	COG0569	domain protein
AS53_RS02735	COG0583	DNA-binding transcription factor activity
AS53_RS02740	COG0517	IMP dehydrogenase activity
AS53_RS02750	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AS53_RS02760	COG4703	Protein of unknown function (DUF1797)
AS53_RS02775	COG2200	EAL domain
AS53_RS02780	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS02785	COG1408	metallophosphoesterase
AS53_RS02795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AS53_RS02835	COG2814	Major facilitator Superfamily
AS53_RS02860	COG3209	COG3209 Rhs family protein
AS53_RS02870	COG2205	protein histidine kinase activity
AS53_RS02880	COG0436	Aminotransferase
AS53_RS02885	COG1609	Transcriptional regulator
AS53_RS02890	COG3833	ABC-type maltose transport systems, permease component
AS53_RS02895	COG1175	transmembrane transport
AS53_RS02900	COG2182	Extracellular solute-binding protein
AS53_RS02910	COG0366	Alpha amylase catalytic
AS53_RS02915	COG3842	ATPase activity
AS53_RS02955	COG0183	Belongs to the thiolase family
AS53_RS02995	COG1695	Transcriptional regulator
AS53_RS03000	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS03010	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AS53_RS03020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS53_RS03025	COG0436	Aminotransferase
AS53_RS03045	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AS53_RS03065	COG2199	diguanylate cyclase activity
AS53_RS03070	COG0778	Nitroreductase
AS53_RS03095	COG1263	PTS System
AS53_RS03095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_RS03095	COG2190	(PTS) system
AS53_RS03100	COG3711	transcriptional antiterminator
AS53_RS03110	COG2188	Transcriptional regulator
AS53_RS03120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AS53_RS03150	COG1547	Domain of unknown function (DUF309)
AS53_RS03155	COG0456	acetyltransferase
AS53_RS03165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AS53_RS03170	COG4086	secreted protein
AS53_RS03175	COG0561	phosphatase activity
AS53_RS03180	COG0697	spore germination
AS53_RS03195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_RS03220	COG0733	neurotransmitter:sodium symporter activity
AS53_RS03240	COG1686	Belongs to the peptidase S11 family
AS53_RS03245	COG1725	Transcriptional regulator
AS53_RS03250	COG1131	(ABC) transporter
AS53_RS03270	COG1846	Transcriptional regulator
AS53_RS03285	COG0598	Magnesium transport protein CorA
AS53_RS03310	COG4974	Belongs to the 'phage' integrase family
AS53_RS03320	COG0735	belongs to the Fur family
AS53_RS03325	COG1300	Membrane
AS53_RS03345	COG0667	Aldo Keto reductase
AS53_RS03350	COG0656	L-ascorbic acid biosynthetic process
AS53_RS03355	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS53_RS03355	COG0456	acetyltransferase
AS53_RS03365	COG1525	nuclease
AS53_RS03365	COG4085	toxin activity
AS53_RS03365	COG0737	Belongs to the 5'-nucleotidase family
AS53_RS03375	COG0596	Alpha beta hydrolase
AS53_RS03380	COG2056	Na+-H+ antiporter family
AS53_RS03390	COG0456	acetyltransferase
AS53_RS03395	COG1073	alpha beta
AS53_RS03410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS53_RS03410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS53_RS03415	COG0307	riboflavin synthase, alpha
AS53_RS03440	COG4106	trans-aconitate 2-methyltransferase activity
AS53_RS03445	COG2226	methyltransferase
AS53_RS03445	COG1073	alpha beta
AS53_RS03460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS53_RS03470	COG1757	Na H antiporter
AS53_RS03475	COG0737	Belongs to the 5'-nucleotidase family
AS53_RS03485	COG1522	sequence-specific DNA binding
AS53_RS03505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AS53_RS03515	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AS53_RS03530	COG0300	oxidoreductase activity
AS53_RS03535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_RS03545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS53_RS03550	COG1760	l-serine dehydratase
AS53_RS03555	COG1760	l-serine dehydratase
AS53_RS03575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS53_RS03585	COG2195	Cleaves the N-terminal amino acid of tripeptides
AS53_RS03590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_RS03605	COG1376	ErfK ybiS ycfS ynhG family protein
AS53_RS03610	COG4129	membrane
AS53_RS03615	COG1126	abc transporter atp-binding protein
AS53_RS03620	COG0765	amino acid transport
AS53_RS03625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS53_RS03645	COG0772	Belongs to the SEDS family
AS53_RS03655	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS53_RS03660	COG0022	dehydrogenase e1 component
AS53_RS03665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS53_RS03670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS53_RS03685	COG0280	phosphate acetyltransferase
AS53_RS03695	COG3829	transcription factor binding
AS53_RS03695	COG3290	protein histidine kinase activity
AS53_RS03705	COG0584	glycerophosphoryl diester phosphodiesterase
AS53_RS03710	COG3093	addiction module antidote protein HigA
AS53_RS03720	COG0745	RESPONSE REGULATOR receiver
AS53_RS03730	COG0750	zinc metalloprotease
AS53_RS03735	COG0497	DNA recombination
AS53_RS03745	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AS53_RS03755	COG0142	geranyltranstransferase activity
AS53_RS03780	COG1302	Protein conserved in bacteria
AS53_RS03785	COG0439	Biotin carboxylase
AS53_RS03790	COG0511	ligase activity, forming carbon-carbon bonds
AS53_RS03835	COG3854	ATPases associated with a variety of cellular activities
AS53_RS03860	COG0006	proline dipeptidase activity
AS53_RS03875	COG3872	metal-dependent enzyme
AS53_RS03885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS53_RS03905	COG0095	Lipoate-protein ligase
AS53_RS03910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_RS03915	COG1609	Transcriptional regulator
AS53_RS03925	COG2076	Multidrug Resistance protein
AS53_RS03930	COG2076	Multidrug Resistance protein
AS53_RS03970	COG1131	(ABC) transporter
AS53_RS03975	COG1725	Transcriptional regulator
AS53_RS04005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS53_RS04060	COG4970	Tfp pilus assembly protein FimT
AS53_RS04070	COG1459	type II secretion system
AS53_RS04075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AS53_RS04125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS53_RS04130	COG1410	methionine synthase
AS53_RS04130	COG0646	methionine synthase
AS53_RS04135	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AS53_RS04135	COG0646	methionine synthase
AS53_RS04145	COG0626	cystathionine gamma-synthase activity
AS53_RS04150	COG0626	cystathionine gamma-synthase activity
AS53_RS04175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_RS04185	COG1940	carbohydrate kinase activity
AS53_RS04190	COG4483	Protein conserved in bacteria
AS53_RS04195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AS53_RS04200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AS53_RS04205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AS53_RS04210	COG0704	Plays a role in the regulation of phosphate uptake
AS53_RS04220	COG0581	inorganic phosphate transmembrane transporter activity
AS53_RS04225	COG0573	inorganic phosphate transmembrane transporter activity
AS53_RS04230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AS53_RS04235	COG0768	penicillin binding
AS53_RS04240	COG0477	Major facilitator Superfamily
AS53_RS04245	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AS53_RS04270	COG0735	belongs to the Fur family
AS53_RS04275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS53_RS04280	COG1121	(ABC) transporter
AS53_RS04285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_RS04315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS53_RS04320	COG2384	SAM-dependent methyltransferase
AS53_RS04325	COG2010	Cytochrome c
AS53_RS04330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AS53_RS04335	COG0358	DNA primase activity
AS53_RS04355	COG0517	IMP dehydrogenase activity
AS53_RS04370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AS53_RS04375	COG0295	cytidine deaminase activity
AS53_RS04380	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AS53_RS04390	COG1480	7TM receptor with intracellular HD hydrolase
AS53_RS04395	COG1702	phosphate starvation-inducible protein PhoH
AS53_RS04415	COG1610	YqeY-like protein
AS53_RS04420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AS53_RS04425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS53_RS04430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AS53_RS04460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS53_RS04465	COG1733	regulation of RNA biosynthetic process
AS53_RS04490	COG1466	dna polymerase III delta subunit
AS53_RS04500	COG2333	competence protein COMEC
AS53_RS04500	COG0658	competence protein
AS53_RS04505	COG2131	deaminase
AS53_RS04510	COG1555	photosystem II stabilization
AS53_RS04510	COG1596	polysaccharide export
AS53_RS04515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS53_RS04520	COG2226	methyltransferase
AS53_RS04525	COG0799	negative regulation of ribosome biogenesis
AS53_RS04530	COG1713	HD superfamily hydrolase involved in NAD metabolism
AS53_RS04540	COG1534	Rna-binding protein
AS53_RS04550	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AS53_RS04555	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AS53_RS04580	COG1595	DNA-templated transcription, initiation
AS53_RS04590	COG0778	Nitroreductase
AS53_RS04595	COG2357	RelA SpoT domain protein
AS53_RS04605	COG1785	Belongs to the alkaline phosphatase family
AS53_RS04615	COG2267	carboxylic ester hydrolase activity
AS53_RS04650	COG1404	Belongs to the peptidase S8 family
AS53_RS04655	COG3186	Phenylalanine-4-hydroxylase
AS53_RS04665	COG2514	catechol 2,3-dioxygenase activity
AS53_RS04670	COG2514	catechol 2,3-dioxygenase activity
AS53_RS04675	COG2259	Doxx family
AS53_RS04715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_RS04725	COG1454	alcohol dehydrogenase
AS53_RS04725	COG1012	belongs to the aldehyde dehydrogenase family
AS53_RS04730	COG0626	cystathionine gamma-synthase activity
AS53_RS04735	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS53_RS04760	COG0768	penicillin binding
AS53_RS04775	COG0826	peptidase U32
AS53_RS04780	COG0826	peptidase U32
AS53_RS04785	COG4122	O-methyltransferase activity
AS53_RS04790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AS53_RS04810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AS53_RS04820	COG0628	permease
AS53_RS04840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS53_RS04850	COG0482	sulfurtransferase activity
AS53_RS04855	COG1104	cysteine desulfurase activity
AS53_RS04860	COG1959	2 iron, 2 sulfur cluster binding
AS53_RS04865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AS53_RS04875	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AS53_RS04900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS53_RS04910	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AS53_RS04910	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AS53_RS04915	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AS53_RS04920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS53_RS04920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS53_RS04930	COG2244	polysaccharide biosynthetic process
AS53_RS04935	COG2323	membrane
AS53_RS04945	COG1862	Preprotein translocase
AS53_RS04975	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AS53_RS04985	COG0697	spore germination
AS53_RS04990	COG0697	spore germination
AS53_RS04995	COG0640	Transcriptional regulator
AS53_RS05020	COG0157	Belongs to the NadC ModD family
AS53_RS05025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AS53_RS05030	COG1104	cysteine desulfurase activity
AS53_RS05035	COG1827	regulation of RNA biosynthetic process
AS53_RS05040	COG2258	MOSC domain
AS53_RS05045	COG0077	Prephenate dehydratase
AS53_RS05050	COG0577	efflux transmembrane transporter activity
AS53_RS05055	COG0577	efflux transmembrane transporter activity
AS53_RS05060	COG1136	(ABC) transporter
AS53_RS05065	COG5002	protein histidine kinase activity
AS53_RS05075	COG0745	RESPONSE REGULATOR receiver
AS53_RS05080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AS53_RS05085	COG3290	protein histidine kinase activity
AS53_RS05095	COG2868	ribosomal protein
AS53_RS05105	COG1530	ribonuclease E activity
AS53_RS05110	COG1994	Peptidase M50
AS53_RS05115	COG0739	heme binding
AS53_RS05120	COG2894	cell division
AS53_RS05140	COG1077	Cell shape determining protein MreB Mrl
AS53_RS05160	COG0285	dihydrofolate synthase activity
AS53_RS05165	COG0525	valine-tRNA ligase activity
AS53_RS05175	COG1388	LysM domain
AS53_RS05185	COG0113	porphobilinogen synthase activity
AS53_RS05190	COG1587	Uroporphyrinogen-III synthase
AS53_RS05200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS53_RS05210	COG1846	Transcriptional regulator
AS53_RS05215	COG1764	response to oxidative stress
AS53_RS05230	COG0470	DNA polymerase III
AS53_RS05230	COG1067	ATP-dependent peptidase activity
AS53_RS05280	COG0622	Phosphoesterase
AS53_RS05295	COG5401	PFAM Sporulation and spore germination
AS53_RS05315	COG1309	transcriptional regulator
AS53_RS05330	COG2197	response regulator
AS53_RS05335	COG2233	PERMEase
AS53_RS05345	COG0402	S-adenosylhomocysteine deaminase activity
AS53_RS05350	COG0402	S-adenosylhomocysteine deaminase activity
AS53_RS05360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS53_RS05370	COG0444	Belongs to the ABC transporter superfamily
AS53_RS05375	COG4608	Belongs to the ABC transporter superfamily
AS53_RS05380	COG3275	phosphorelay sensor kinase activity
AS53_RS05385	COG3279	Response regulator of the LytR AlgR family
AS53_RS05400	COG1983	PspC domain protein
AS53_RS05405	COG1396	sequence-specific DNA binding
AS53_RS05410	COG0697	spore germination
AS53_RS05420	COG1959	2 iron, 2 sulfur cluster binding
AS53_RS05425	COG1668	transmembrane transport
AS53_RS05430	COG4152	abc transporter atp-binding protein
AS53_RS05435	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AS53_RS05445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AS53_RS05450	COG1876	peptidase activity
AS53_RS05455	COG0824	Thioesterase
AS53_RS05460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AS53_RS05465	COG1053	succinate dehydrogenase
AS53_RS05470	COG2009	succinate dehydrogenase
AS53_RS05475	COG1719	4-vinyl reductase, 4VR
AS53_RS05485	COG3118	belongs to the thioredoxin family
AS53_RS05490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AS53_RS05495	COG2086	electron transfer activity
AS53_RS05500	COG1024	Enoyl-CoA hydratase
AS53_RS05505	COG1309	transcriptional regulator
AS53_RS05510	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_RS05530	COG2318	DinB family
AS53_RS05560	COG1131	(ABC) transporter
AS53_RS05565	COG2205	protein histidine kinase activity
AS53_RS05570	COG0745	RESPONSE REGULATOR receiver
AS53_RS05580	COG4895	conserved protein (DUF2196)
AS53_RS05585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AS53_RS05600	COG4509	Sortase family
AS53_RS05605	COG1120	ATPase activity
AS53_RS05620	COG5386	Cell surface protein
AS53_RS05630	COG5386	Cell surface protein
AS53_RS05635	COG1114	Component of the transport system for branched-chain amino acids
AS53_RS05640	COG1187	pseudouridine synthase activity
AS53_RS05655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AS53_RS05655	COG1796	DNA polymerase
AS53_RS05660	COG1286	toxin biosynthetic process
AS53_RS05705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS53_RS05715	COG1418	mRNA catabolic process
AS53_RS05740	COG2814	Major facilitator Superfamily
AS53_RS05745	COG1566	PFAM secretion protein HlyD family protein
AS53_RS05750	COG1309	transcriptional regulator
AS53_RS05755	COG1363	Peptidase, m42
AS53_RS05780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS53_RS05790	COG1484	DNA-dependent DNA replication
AS53_RS05805	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AS53_RS05810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS53_RS05815	COG0237	dephospho-CoA kinase activity
AS53_RS05820	COG1971	Probably functions as a manganese efflux pump
AS53_RS05830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS53_RS05830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS53_RS05835	COG5002	protein histidine kinase activity
AS53_RS05840	COG0745	RESPONSE REGULATOR receiver
AS53_RS05860	COG0538	isocitrate dehydrogenase activity
AS53_RS05865	COG0372	Belongs to the citrate synthase family
AS53_RS05880	COG0628	permease
AS53_RS05885	COG3030	protein affecting phage T7 exclusion by the F plasmid
AS53_RS05910	COG1725	Transcriptional regulator
AS53_RS05915	COG0281	malic enzyme
AS53_RS05920	COG0587	DNA-directed DNA polymerase activity
AS53_RS05935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AS53_RS05955	COG4109	DRTGG domain
AS53_RS05970	COG0006	proline dipeptidase activity
AS53_RS06005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_RS06010	COG0662	Cupin 2, conserved barrel domain protein
AS53_RS06020	COG1476	TRANSCRIPTIONal
AS53_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS06040	COG0589	response to stress
AS53_RS06080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_RS06100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AS53_RS06105	COG0827	DNA restriction-modification system
AS53_RS06110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AS53_RS06115	COG3874	Sporulation protein YtfJ
AS53_RS06130	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AS53_RS06140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS53_RS06155	COG1104	cysteine desulfurase activity
AS53_RS06165	COG0583	DNA-binding transcription factor activity
AS53_RS06170	COG0697	spore germination
AS53_RS06180	COG1956	GAF domain-containing protein
AS53_RS06185	COG0626	cystathionine gamma-synthase activity
AS53_RS06215	COG1595	DNA-templated transcription, initiation
AS53_RS06225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS53_RS06230	COG0454	-acetyltransferase
AS53_RS06235	COG0517	IMP dehydrogenase activity
AS53_RS06240	COG0123	including yeast histone deacetylase and acetoin utilization protein
AS53_RS06250	COG0745	RESPONSE REGULATOR receiver
AS53_RS06260	COG0666	response to abiotic stimulus
AS53_RS06295	COG1609	Transcriptional regulator
AS53_RS06305	COG4851	CamS sex pheromone cAM373 precursor
AS53_RS06310	COG3118	belongs to the thioredoxin family
AS53_RS06320	COG2309	aminopeptidase activity
AS53_RS06340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_RS06355	COG1674	ftsk spoiiie
AS53_RS06365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS53_RS06370	COG4848	Belongs to the UPF0354 family
AS53_RS06375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS53_RS06380	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AS53_RS06385	COG1363	Peptidase, m42
AS53_RS06395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_RS06410	COG0510	thiamine kinase activity
AS53_RS06415	COG1523	belongs to the glycosyl hydrolase 13 family
AS53_RS06430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS53_RS06435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS53_RS06440	COG1349	DNA-binding transcription factor activity
AS53_RS06445	COG1187	pseudouridine synthase activity
AS53_RS06450	COG2244	polysaccharide biosynthetic process
AS53_RS06455	COG2081	HI0933 family
AS53_RS06460	COG2814	Major facilitator Superfamily
AS53_RS06470	COG3832	glyoxalase III activity
AS53_RS06490	COG1329	Transcriptional regulator
AS53_RS06500	COG4975	Glucose uptake
AS53_RS06515	COG0314	molybdopterin synthase activity
AS53_RS06520	COG1763	Mo-molybdopterin cofactor biosynthetic process
AS53_RS06525	COG0303	'Molybdopterin
AS53_RS06535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS53_RS06560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_RS06570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS53_RS06615	COG2814	Major facilitator Superfamily
AS53_RS06620	COG0475	glutathione-regulated potassium exporter activity
AS53_RS06625	COG0490	domain, Protein
AS53_RS06630	COG0582	viral genome integration into host DNA
AS53_RS06640	COG1136	(ABC) transporter
AS53_RS06660	COG1242	4 iron, 4 sulfur cluster binding
AS53_RS06665	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AS53_RS06670	COG1131	(ABC) transporter
AS53_RS06680	COG1794	racemase activity, acting on amino acids and derivatives
AS53_RS06700	COG2267	carboxylic ester hydrolase activity
AS53_RS06705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AS53_RS06710	COG0671	phosphoesterase, PA-phosphatase related
AS53_RS06715	COG0438	transferase activity, transferring glycosyl groups
AS53_RS06725	COG0521	Mo-molybdopterin cofactor biosynthetic process
AS53_RS06780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS53_RS06785	COG5002	protein histidine kinase activity
AS53_RS06790	COG4191	Histidine kinase
AS53_RS06795	COG2267	carboxylic ester hydrolase activity
AS53_RS06815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS53_RS06820	COG1116	anion transmembrane transporter activity
AS53_RS06825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS53_RS06850	COG0494	nUDIX hydrolase
AS53_RS06880	COG0288	reversible hydration of carbon dioxide
AS53_RS06885	COG1271	oxidase subunit
AS53_RS06890	COG1294	oxidase, subunit
AS53_RS06910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_RS06935	COG1842	Phage shock protein A
AS53_RS06970	COG5002	protein histidine kinase activity
AS53_RS06975	COG0745	RESPONSE REGULATOR receiver
AS53_RS07005	COG1597	lipid kinase activity
AS53_RS07040	COG0586	Pfam SNARE associated Golgi protein
AS53_RS07050	COG0577	efflux transmembrane transporter activity
AS53_RS07055	COG1136	(ABC) transporter
AS53_RS07060	COG2207	Transcriptional regulator
AS53_RS07060	COG3708	Transcriptional regulator
AS53_RS07065	COG0745	RESPONSE REGULATOR receiver
AS53_RS07070	COG2205	protein histidine kinase activity
AS53_RS07075	COG0577	efflux transmembrane transporter activity
AS53_RS07085	COG0577	efflux transmembrane transporter activity
AS53_RS07090	COG0577	efflux transmembrane transporter activity
AS53_RS07095	COG1136	(ABC) transporter
AS53_RS07115	COG2188	Transcriptional regulator
AS53_RS07135	COG3964	amidohydrolase
AS53_RS07165	COG4948	Mandelate Racemase Muconate Lactonizing
AS53_RS07175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AS53_RS07180	COG0596	Alpha beta hydrolase
AS53_RS07185	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AS53_RS07190	COG1169	isochorismate synthase
AS53_RS07195	COG1575	Belongs to the MenA family. Type 1 subfamily
AS53_RS07200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AS53_RS07225	COG0058	SHG alpha-glucan phosphorylase activity
AS53_RS07230	COG0297	glycogen (starch) synthase activity
AS53_RS07235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AS53_RS07345	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS53_RS07425	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS53_RS07460	COG1285	pathogenesis
AS53_RS07465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS53_RS07475	COG0166	Belongs to the GPI family
AS53_RS07485	COG2155	Conserved Protein
AS53_RS07490	COG1098	S1 RNA binding domain
AS53_RS07495	COG0436	Aminotransferase
AS53_RS07500	COG1522	sequence-specific DNA binding
AS53_RS07505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS53_RS07510	COG2267	carboxylic ester hydrolase activity
AS53_RS07520	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AS53_RS07540	COG5018	Exonuclease
AS53_RS07545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS53_RS07565	COG2050	protein possibly involved in aromatic compounds catabolism
AS53_RS07575	COG1268	BioY protein
AS53_RS07585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS53_RS07590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS53_RS07605	COG3584	3D domain protein
AS53_RS07620	COG1252	NADH dehydrogenase
AS53_RS07635	COG3708	Transcriptional regulator
AS53_RS07650	COG1683	Conserved Protein
AS53_RS07670	COG0316	Belongs to the HesB IscA family
AS53_RS07685	COG1252	NADH dehydrogenase
AS53_RS07700	COG0390	transport system, permease component
AS53_RS07705	COG2824	Alkylphosphonate utilization operon protein PhnA
AS53_RS07745	COG4837	Protein of unknown function (DUF1462)
AS53_RS07750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AS53_RS07760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS53_RS07765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AS53_RS07780	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS53_RS07785	COG0647	UMP catabolic process
AS53_RS07795	COG2445	Protein of unknown function DUF86
AS53_RS07800	COG1494	fructose-1,6-bisphosphatase
AS53_RS07820	COG4470	Protein conserved in bacteria
AS53_RS07830	COG0789	Transcriptional regulator
AS53_RS07835	COG4377	Putative membrane peptidase family (DUF2324)
AS53_RS07860	COG0739	heme binding
AS53_RS07870	COG3377	Domain of unknown function (DUF1805)
AS53_RS07875	COG0737	Belongs to the 5'-nucleotidase family
AS53_RS07885	COG1695	Transcriptional regulator
AS53_RS07900	COG0719	Fe-S assembly protein
AS53_RS07905	COG0822	iron-sulfur transferase activity
AS53_RS07910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AS53_RS07915	COG0719	Fe-S assembly protein
AS53_RS07920	COG0396	ATPase activity
AS53_RS07930	COG1464	Belongs to the NlpA lipoprotein family
AS53_RS07935	COG2011	ABC-type metal ion transport system permease component
AS53_RS07940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS53_RS07955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS53_RS07960	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AS53_RS07970	COG1393	Belongs to the ArsC family
AS53_RS08020	COG0039	L-malate dehydrogenase activity
AS53_RS08040	COG1309	transcriptional regulator
AS53_RS08045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_RS08050	COG1960	acyl-CoA dehydrogenase activity
AS53_RS08060	COG0183	Belongs to the thiolase family
AS53_RS08065	COG1024	Enoyl-CoA hydratase
AS53_RS08065	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS53_RS08075	COG1686	Belongs to the peptidase S11 family
AS53_RS08090	COG0011	TIGRFAM Protein of
AS53_RS08095	COG0840	transmembrane signaling receptor activity
AS53_RS08115	COG2814	Major facilitator Superfamily
AS53_RS08120	COG0531	amino acid
AS53_RS08130	COG0706	membrane insertase activity
AS53_RS08140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_RS08175	COG0586	Pfam SNARE associated Golgi protein
AS53_RS08185	COG1376	ErfK ybiS ycfS ynhG family protein
AS53_RS08190	COG0745	RESPONSE REGULATOR receiver
AS53_RS08195	COG5002	protein histidine kinase activity
AS53_RS08220	COG2151	metal-sulfur cluster biosynthetic enzyme
AS53_RS08225	COG3227	Zinc metalloprotease (Elastase)
AS53_RS08230	COG1741	Belongs to the pirin family
AS53_RS08245	COG0475	glutathione-regulated potassium exporter activity
AS53_RS08250	COG0490	domain, Protein
AS53_RS08260	COG1115	amino acid carrier protein
AS53_RS08265	COG0783	Belongs to the Dps family
AS53_RS08280	COG1611	Belongs to the LOG family
AS53_RS08295	COG2311	Membrane
AS53_RS08305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_RS08310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_RS08315	COG1115	amino acid carrier protein
AS53_RS08320	COG1115	amino acid carrier protein
AS53_RS08325	COG2910	NAD(P)H-binding
AS53_RS08340	COG0656	L-ascorbic acid biosynthetic process
AS53_RS08345	COG2814	Major facilitator Superfamily
AS53_RS08350	COG1733	regulation of RNA biosynthetic process
AS53_RS08360	COG1252	NADH dehydrogenase
AS53_RS08365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AS53_RS08370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AS53_RS08380	COG0840	transmembrane signaling receptor activity
AS53_RS08380	COG3290	protein histidine kinase activity
AS53_RS08390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS53_RS08395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS53_RS08410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_RS08460	COG0557	exoribonuclease II activity
AS53_RS08465	COG1647	Serine aminopeptidase, S33
AS53_RS08470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS53_RS08475	COG1346	cytolysis
AS53_RS08575	COG4695	Portal protein
AS53_RS08600	COG4974	Belongs to the 'phage' integrase family
AS53_RS08610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AS53_RS08615	COG0149	triose-phosphate isomerase activity
AS53_RS08625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS53_RS08640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AS53_RS08665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_RS08680	COG2323	membrane
AS53_RS08685	COG0740	serine-type endopeptidase activity
AS53_RS08690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS53_RS08700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AS53_RS08710	COG1051	belongs to the nudix hydrolase family
AS53_RS08720	COG0492	ferredoxin-NADP+ reductase activity
AS53_RS08725	COG0457	Tetratricopeptide repeat
AS53_RS08730	COG0110	maltose O-acetyltransferase activity
AS53_RS08750	COG1950	PFAM Membrane protein of
AS53_RS08760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AS53_RS08765	COG0556	nucleotide-excision repair
AS53_RS08785	COG0789	Transcriptional regulator
AS53_RS08810	COG2855	membrane
AS53_RS08815	COG0583	DNA-binding transcription factor activity
AS53_RS08825	COG0655	NAD(P)H dehydrogenase (quinone) activity
AS53_RS08830	COG0488	(ABC) transporter
AS53_RS08840	COG1132	(ABC) transporter
AS53_RS08845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS53_RS08850	COG0793	Belongs to the peptidase S41A family
AS53_RS08850	COG3409	Peptidoglycan-binding domain 1 protein
AS53_RS08855	COG2177	Part of the ABC transporter FtsEX involved in
AS53_RS08860	COG2884	Cell division ATP-binding protein ftsE
AS53_RS08875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AS53_RS08880	COG0653	protein targeting
AS53_RS08885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AS53_RS08890	COG1278	Cold shock
AS53_RS08895	COG1040	competence protein
AS53_RS08900	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AS53_RS08905	COG1388	LysM domain
AS53_RS08905	COG0791	NLP P60 protein
AS53_RS08910	COG1733	regulation of RNA biosynthetic process
AS53_RS08920	COG1307	EDD domain protein, DegV family
AS53_RS08925	COG1739	Uncharacterized protein family UPF0029
AS53_RS08930	COG1316	TRANSCRIPTIONal
AS53_RS08935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AS53_RS08940	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AS53_RS08945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS53_RS08955	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AS53_RS08955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AS53_RS08970	COG3394	polysaccharide catabolic process
AS53_RS08975	COG1486	melibiose metabolic process
AS53_RS08980	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS53_RS08985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS53_RS08995	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AS53_RS09000	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AS53_RS09005	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS53_RS09015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS53_RS09020	COG1301	dicarboxylic acid transport
AS53_RS09030	COG0346	lactoylglutathione lyase activity
AS53_RS09035	COG1511	domain protein
AS53_RS09040	COG0583	DNA-binding transcription factor activity
AS53_RS09045	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AS53_RS09060	COG1271	oxidase subunit
AS53_RS09065	COG1294	oxidase, subunit
AS53_RS09070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS53_RS09090	COG2389	metal-binding protein
AS53_RS09100	COG1368	sulfuric ester hydrolase activity
AS53_RS09115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_RS09125	COG1215	transferase activity, transferring glycosyl groups
AS53_RS09135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS53_RS09140	COG1388	LysM domain
AS53_RS09140	COG3584	3D domain protein
AS53_RS09165	COG4715	Zinc finger, swim domain protein
AS53_RS09170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS53_RS09210	COG0577	efflux transmembrane transporter activity
AS53_RS09215	COG1136	(ABC) transporter
AS53_RS09250	COG5002	protein histidine kinase activity
AS53_RS09255	COG0745	RESPONSE REGULATOR receiver
AS53_RS09260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS53_RS09275	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AS53_RS09285	COG1682	transport, permease protein
AS53_RS09290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AS53_RS09335	COG1609	Transcriptional regulator
AS53_RS09350	COG0739	heme binding
AS53_RS09365	COG3279	Response regulator of the LytR AlgR family
AS53_RS09370	COG4555	ABC transporter
AS53_RS09375	COG2385	sporulation resulting in formation of a cellular spore
AS53_RS09390	COG4836	Membrane
AS53_RS09395	COG1007	ATP synthesis coupled electron transport
AS53_RS09400	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS53_RS09405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS53_RS09415	COG0839	Belongs to the complex I subunit 6 family
AS53_RS09430	COG0649	NAD binding
AS53_RS09435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS53_RS09450	COG5001	Diguanylate cyclase
AS53_RS09450	COG3300	MHYT domain
AS53_RS09500	COG0356	it plays a direct role in the translocation of protons across the membrane
AS53_RS09535	COG0698	ribose 5-phosphate isomerase
AS53_RS09545	COG2190	(PTS) system
AS53_RS09550	COG2259	Doxx family
AS53_RS09555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS53_RS09570	COG0009	L-threonylcarbamoyladenylate synthase
AS53_RS09585	COG2890	protein-(glutamine-N5) methyltransferase activity
AS53_RS09605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AS53_RS09610	COG1494	fructose-1,6-bisphosphatase
AS53_RS09630	COG4821	SIS domain
AS53_RS09640	COG3343	RNA polymerase activity
AS53_RS09650	COG1960	acyl-CoA dehydrogenase activity
AS53_RS09655	COG1960	acyl-CoA dehydrogenase activity
AS53_RS09660	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS53_RS09665	COG0183	Belongs to the thiolase family
AS53_RS09670	COG0247	lactate metabolic process
AS53_RS09670	COG2181	nitrate reductase activity
AS53_RS09675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS53_RS09685	COG3300	MHYT domain
AS53_RS09685	COG5001	Diguanylate cyclase
AS53_RS09700	COG2197	response regulator
AS53_RS09705	COG4585	Histidine kinase
AS53_RS09710	COG0842	Transport permease protein
AS53_RS09715	COG1131	(ABC) transporter
AS53_RS09720	COG0024	Methionine aminopeptidase
AS53_RS09740	COG2234	aminopeptidase activity
AS53_RS09760	COG1595	DNA-templated transcription, initiation
AS53_RS09765	COG0018	arginyl-trna synthetase
AS53_RS09770	COG4506	Protein conserved in bacteria
AS53_RS09775	COG1619	proteins homologs of microcin C7 resistance protein MccF
AS53_RS09795	COG0010	Belongs to the arginase family
AS53_RS09805	COG2814	Major facilitator Superfamily
AS53_RS09810	COG0789	Transcriptional regulator
AS53_RS09815	COG0584	glycerophosphoryl diester phosphodiesterase
AS53_RS09820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS53_RS09830	COG1994	Peptidase M50
AS53_RS09840	COG1078	dGTPase activity
AS53_RS09845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_RS09850	COG1120	ATPase activity
AS53_RS09855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_RS09860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_RS09865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_RS09885	COG0095	Lipoate-protein ligase
AS53_RS09890	COG0280	phosphate acetyltransferase
AS53_RS09905	COG3773	Cell wall hydrolase
AS53_RS09915	COG2363	Small membrane protein
AS53_RS09925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS53_RS09930	COG2233	PERMEase
AS53_RS09935	COG0561	phosphatase activity
AS53_RS09940	COG2814	Major facilitator Superfamily
AS53_RS09950	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS53_RS09955	COG1131	(ABC) transporter
AS53_RS09960	COG2755	lipolytic protein G-D-S-L family
AS53_RS09965	COG1609	Transcriptional regulator
AS53_RS09975	COG0460	homoserine dehydrogenase
AS53_RS09985	COG2873	o-acetylhomoserine
AS53_RS09995	COG1011	Hydrolase
AS53_RS10000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS53_RS10010	COG2197	response regulator
AS53_RS10020	COG0351	phosphomethylpyrimidine kinase
AS53_RS10025	COG3706	GGDEF domain
AS53_RS10030	COG2879	small protein
AS53_RS10035	COG1966	Carbon starvation protein
AS53_RS10040	COG3279	Response regulator of the LytR AlgR family
AS53_RS10045	COG0477	Major facilitator Superfamily
AS53_RS10070	COG0840	transmembrane signaling receptor activity
AS53_RS10080	COG1607	acyl-coa hydrolase
AS53_RS10095	COG0488	(ABC) transporter
AS53_RS10120	COG0463	Glycosyl transferase, family 2
AS53_RS10125	COG1309	transcriptional regulator
AS53_RS10130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS53_RS10135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS53_RS10135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS53_RS10140	COG0628	permease
AS53_RS10155	COG3279	Response regulator of the LytR AlgR family
AS53_RS10160	COG3275	phosphorelay sensor kinase activity
AS53_RS10165	COG2814	Major facilitator Superfamily
AS53_RS10175	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AS53_RS10180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AS53_RS10200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS53_RS10205	COG1272	protein, Hemolysin III
AS53_RS10225	COG0516	GMP reductase activity
AS53_RS10250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS53_RS10255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AS53_RS10260	COG4853	Protein conserved in bacteria
AS53_RS10265	COG4863	YycH protein
AS53_RS10270	COG5002	protein histidine kinase activity
AS53_RS10275	COG0745	RESPONSE REGULATOR receiver
AS53_RS10305	COG0305	Participates in initiation and elongation during chromosome replication
AS53_RS10315	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AS53_RS10320	COG4241	membrane
AS53_RS10330	COG0629	single-stranded DNA binding
AS53_RS10340	COG0012	GTP binding
AS53_RS10345	COG4481	Protein conserved in bacteria
AS53_RS10350	COG0668	transmembrane transport
AS53_RS10360	COG1475	DNA binding
AS53_RS10365	COG1192	Involved in chromosome partitioning
AS53_RS10390	COG1847	R3H domain protein
AS53_RS10395	COG0706	membrane insertase activity
AS53_RS10405	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AS53_RS10415	COG0592	DNA-directed DNA polymerase activity
AS53_RS10420	COG2501	S4 domain
AS53_RS10430	COG0187	DNA topoisomerase II activity
AS53_RS10435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AS53_RS10460	COG0516	GMP reductase activity
AS53_RS10460	COG0517	IMP dehydrogenase activity
AS53_RS10465	COG1686	Belongs to the peptidase S11 family
AS53_RS10495	COG1428	Deoxynucleoside kinase
AS53_RS10500	COG1428	Deoxynucleoside kinase
AS53_RS10505	COG1335	isochorismatase
AS53_RS10515	COG0590	tRNA wobble adenosine to inosine editing
AS53_RS10520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AS53_RS10575	COG1982	Orn Lys Arg decarboxylase major
AS53_RS10585	COG0470	DNA polymerase III
AS53_RS10590	COG1774	PSP1 C-terminal conserved region
AS53_RS10600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AS53_RS10610	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AS53_RS10615	COG2002	toxin-antitoxin pair type II binding
AS53_RS10620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS53_RS10620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS53_RS10630	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AS53_RS10645	COG4466	Protein conserved in bacteria
AS53_RS10660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS53_RS10665	COG0251	oxidation-reduction process
AS53_RS10695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AS53_RS10700	COG2002	toxin-antitoxin pair type II binding
AS53_RS10705	COG2244	polysaccharide biosynthetic process
AS53_RS10710	COG3956	TIGRFAM MazG family protein
AS53_RS10715	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AS53_RS10735	COG1098	S1 RNA binding domain
AS53_RS10755	COG0037	tRNA processing
AS53_RS10760	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AS53_RS10765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS53_RS10780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS53_RS10785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AS53_RS10790	COG0512	Glutamine amidotransferase of anthranilate synthase
AS53_RS10795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS53_RS10800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AS53_RS10805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AS53_RS10810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AS53_RS10815	COG1396	sequence-specific DNA binding
AS53_RS10820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS53_RS10850	COG3880	PFAM UvrB UvrC protein
AS53_RS10860	COG0542	response to heat
AS53_RS10865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AS53_RS10875	COG4956	integral membrane protein (PIN domain superfamily)
AS53_RS10895	COG1045	serine acetyltransferase
AS53_RS10910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS53_RS10915	COG3688	RNA-binding protein containing a PIN domain
AS53_RS10930	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS53_RS10935	COG0250	Participates in transcription elongation, termination and antitermination
AS53_RS10940	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AS53_RS10960	COG2813	Specifically methylates the guanine in position
AS53_RS10970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AS53_RS10975	COG1358	cellular component organization or biogenesis
AS53_RS11045	COG0255	Belongs to the universal ribosomal protein uL29 family
AS53_RS11105	COG0201	protein transport
AS53_RS11115	COG0024	Methionine aminopeptidase
AS53_RS11125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AS53_RS11160	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AS53_RS11185	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS53_RS11190	COG0489	protein tyrosine kinase activity
AS53_RS11200	COG2194	sulfuric ester hydrolase activity
AS53_RS11205	COG0726	polysaccharide deacetylase
AS53_RS11290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AS53_RS11295	COG4856	YbbR-like protein
AS53_RS11310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AS53_RS11315	COG0596	Alpha beta hydrolase
AS53_RS11335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AS53_RS11340	COG4946	Tricorn protease homolog
AS53_RS11340	COG0823	Involved in the tonB-independent uptake of proteins
AS53_RS11340	COG1506	peptidase
AS53_RS11375	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS11380	COG2011	ABC-type metal ion transport system permease component
AS53_RS11385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS53_RS11390	COG1464	Belongs to the NlpA lipoprotein family
AS53_RS11395	COG0604	alcohol dehydrogenase
AS53_RS11405	COG0277	FAD linked oxidase domain protein
AS53_RS11410	COG2271	Major facilitator Superfamily
AS53_RS11420	COG2814	Major facilitator Superfamily
AS53_RS11435	COG0601	transmembrane transport
AS53_RS11440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS53_RS11445	COG0444	Belongs to the ABC transporter superfamily
AS53_RS11450	COG4608	Belongs to the ABC transporter superfamily
AS53_RS11455	COG4166	transmembrane transport
AS53_RS11465	COG2207	Transcriptional regulator
AS53_RS11480	COG4166	transmembrane transport
AS53_RS11485	COG4166	transmembrane transport
AS53_RS11490	COG0656	L-ascorbic acid biosynthetic process
AS53_RS11495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS53_RS11515	COG4149	molybdate abc transporter
AS53_RS11520	COG0725	ABC transporter, periplasmic molybdate-binding protein
AS53_RS11525	COG0725	ABC transporter, periplasmic molybdate-binding protein
AS53_RS11530	COG1910	domain protein
AS53_RS11545	COG0583	DNA-binding transcription factor activity
AS53_RS11550	COG0697	spore germination
AS53_RS11560	COG0204	Acyl-transferase
AS53_RS11570	COG1609	Transcriptional regulator
AS53_RS11580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_RS11595	COG0084	hydrolase, TatD family'
AS53_RS11600	COG5298	Protein conserved in bacteria
AS53_RS11625	COG0488	(ABC) transporter
AS53_RS11640	COG0747	negative chemotaxis
AS53_RS11645	COG0601	transmembrane transport
AS53_RS11650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS53_RS11655	COG0444	Belongs to the ABC transporter superfamily
AS53_RS11660	COG4608	Belongs to the ABC transporter superfamily
AS53_RS11695	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AS53_RS11700	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS53_RS11710	COG2814	Major facilitator Superfamily
AS53_RS11725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AS53_RS11735	COG4294	response to UV
AS53_RS11740	COG0705	Rhomboid family
AS53_RS11740	COG0457	Tetratricopeptide repeat
AS53_RS11750	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AS53_RS11755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS53_RS11760	COG0864	Transcriptional regulator
AS53_RS11765	COG2337	Toxic component of a toxin-antitoxin (TA) module
AS53_RS11770	COG2183	response to ionizing radiation
AS53_RS11865	COG0802	atpase or kinase
AS53_RS11870	COG1214	PFAM Peptidase M22, glycoprotease
AS53_RS11875	COG0456	acetyltransferase
AS53_RS11885	COG0488	(ABC) transporter
AS53_RS11900	COG1266	CAAX protease self-immunity
AS53_RS11920	COG2252	PERMEase
AS53_RS11930	COG5002	protein histidine kinase activity
AS53_RS11960	COG2226	methyltransferase
AS53_RS12015	COG2205	protein histidine kinase activity
AS53_RS12020	COG0745	RESPONSE REGULATOR receiver
AS53_RS12040	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AS53_RS12045	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AS53_RS12050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AS53_RS12060	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS53_RS12075	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AS53_RS12085	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AS53_RS12095	COG0151	Belongs to the GarS family
AS53_RS12120	COG0210	DNA helicase
AS53_RS12130	COG4851	CamS sex pheromone cAM373 precursor
AS53_RS12150	COG1335	isochorismatase
AS53_RS12155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS53_RS12160	COG2011	ABC-type metal ion transport system permease component
AS53_RS12165	COG1464	Belongs to the NlpA lipoprotein family
AS53_RS12185	COG1846	Transcriptional regulator
AS53_RS12210	COG1597	lipid kinase activity
AS53_RS12215	COG0546	phosphoglycolate phosphatase activity
AS53_RS12220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS53_RS12230	COG1012	belongs to the aldehyde dehydrogenase family
AS53_RS12235	COG2076	Multidrug Resistance protein
AS53_RS12240	COG2309	aminopeptidase activity
AS53_RS12255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_RS12260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS53_RS12265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS53_RS12275	COG4807	Protein conserved in bacteria
AS53_RS12300	COG1757	Na H antiporter
AS53_RS12305	COG1473	amidohydrolase
AS53_RS12320	COG0450	alkyl hydroperoxide reductase
AS53_RS12340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_RS12345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_RS12350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_RS12370	COG0166	Belongs to the GPI family
AS53_RS12405	COG5002	protein histidine kinase activity
AS53_RS12425	COG3541	Predicted nucleotidyltransferase
AS53_RS12430	COG2814	Major facilitator Superfamily
AS53_RS12435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS53_RS12435	COG0723	plastoquinol--plastocyanin reductase activity
AS53_RS12445	COG0765	amino acid transport
AS53_RS12450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS53_RS12465	COG0840	transmembrane signaling receptor activity
AS53_RS12470	COG0840	transmembrane signaling receptor activity
AS53_RS12475	COG0366	Alpha amylase catalytic
AS53_RS12480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_RS12480	COG1263	PTS System
AS53_RS12480	COG2190	(PTS) system
AS53_RS12510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AS53_RS12525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS53_RS12535	COG1116	anion transmembrane transporter activity
AS53_RS12540	COG0488	(ABC) transporter
AS53_RS12585	COG2270	Major facilitator Superfamily
AS53_RS12600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS53_RS12615	COG2310	stress, protein
AS53_RS12620	COG2310	stress, protein
AS53_RS12625	COG2310	stress, protein
AS53_RS12630	COG0861	Integral membrane protein TerC family
AS53_RS12640	COG3853	Toxic anion resistance protein (TelA)
AS53_RS12655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AS53_RS12665	COG1295	ribonuclease BN
AS53_RS12670	COG2217	Heavy metal translocating P-type atpase
AS53_RS12675	COG0697	spore germination
AS53_RS12695	COG0586	Pfam SNARE associated Golgi protein
AS53_RS12710	COG3871	stress protein (general stress protein 26)
AS53_RS12715	COG0387	Pfam Sodium calcium exchanger
AS53_RS12725	COG0535	radical SAM domain protein
AS53_RS12750	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AS53_RS12755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS53_RS12760	COG0582	viral genome integration into host DNA
AS53_RS12765	COG1396	sequence-specific DNA binding
AS53_RS12780	COG1396	sequence-specific DNA binding
AS53_RS12815	COG1484	DNA-dependent DNA replication
AS53_RS12910	COG0582	viral genome integration into host DNA
AS53_RS12915	COG0582	viral genome integration into host DNA
AS53_RS13040	COG0101	tRNA pseudouridine synthase activity
AS53_RS13050	COG3829	transcription factor binding
AS53_RS13060	COG0833	amino acid
AS53_RS13065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS53_RS13100	COG1263	PTS System
AS53_RS13100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_RS13105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS53_RS13120	COG0463	Glycosyl transferase, family 2
AS53_RS13135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AS53_RS13135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS53_RS13155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AS53_RS13175	COG1228	amidohydrolase
AS53_RS13180	COG1090	epimerase
AS53_RS13210	COG1988	membrane-bound metal-dependent
AS53_RS13215	COG1194	a g-specific adenine glycosylase
AS53_RS13240	COG1132	(ABC) transporter
AS53_RS13245	COG4129	membrane
AS53_RS13250	COG0070	glutamate synthase
AS53_RS13250	COG0069	glutamate synthase activity
AS53_RS13250	COG0067	glutamate synthase
AS53_RS13260	COG4555	ABC transporter
AS53_RS13280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AS53_RS13285	COG0735	belongs to the Fur family
AS53_RS13365	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS53_RS13400	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AS53_RS13405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AS53_RS13415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AS53_RS13425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AS53_RS13440	COG2766	serine protein kinase
AS53_RS13465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS53_RS13475	COG1585	Membrane protein implicated in regulation of membrane protease activity
AS53_RS13480	COG2268	Band 7 protein
AS53_RS13490	COG3290	protein histidine kinase activity
AS53_RS13495	COG4565	transcriptional regulatory protein
AS53_RS13500	COG2851	Citrate transporter
AS53_RS13520	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AS53_RS13525	COG3842	ATPase activity
AS53_RS13530	COG1175	transmembrane transport
AS53_RS13535	COG0395	ABC-type sugar transport system, permease component
AS53_RS13545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AS53_RS13550	COG0745	RESPONSE REGULATOR receiver
AS53_RS13555	COG5002	protein histidine kinase activity
AS53_RS13565	COG4990	cell redox homeostasis
AS53_RS13580	COG4565	transcriptional regulatory protein
AS53_RS13585	COG3493	citrate carrier protein
AS53_RS13590	COG0281	malic enzyme
AS53_RS13605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_RS13620	COG0745	RESPONSE REGULATOR receiver
AS53_RS13630	COG0456	acetyltransferase
AS53_RS13630	COG0454	-acetyltransferase
AS53_RS13635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS53_RS13640	COG3383	formate dehydrogenase (NAD+) activity
AS53_RS13645	COG2427	Protein of unknown function (DUF1641)
AS53_RS13660	COG0531	amino acid
AS53_RS13665	COG0640	Transcriptional regulator
AS53_RS13675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AS53_RS13685	COG3227	Zinc metalloprotease (Elastase)
AS53_RS13705	COG2720	vancomycin resistance protein
AS53_RS13710	COG1316	TRANSCRIPTIONal
AS53_RS13715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_RS13720	COG0346	lactoylglutathione lyase activity
AS53_RS13725	COG1253	flavin adenine dinucleotide binding
AS53_RS13730	COG1027	Aspartate ammonia-lyase
AS53_RS13735	COG1620	l-lactate permease
AS53_RS13750	COG3104	oligopeptide transport
AS53_RS13755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_RS13760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_RS13765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_RS13775	COG2226	methyltransferase
AS53_RS13780	COG0156	8-amino-7-oxononanoate synthase activity
AS53_RS13785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS53_RS13795	COG4548	von Willebrand factor, type A
AS53_RS13800	COG0714	Associated with various cellular activities
AS53_RS13805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS53_RS13825	COG0531	amino acid
AS53_RS13830	COG2188	Transcriptional regulator
AS53_RS13835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_RS13835	COG1263	PTS System
AS53_RS13840	COG0366	Alpha amylase catalytic
AS53_RS13855	COG0697	spore germination
AS53_RS13865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS53_RS13870	COG1115	amino acid carrier protein
AS53_RS13875	COG1126	abc transporter atp-binding protein
AS53_RS13880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS53_RS13885	COG0765	amino acid transport
AS53_RS13890	COG0765	amino acid transport
AS53_RS13895	COG0833	amino acid
AS53_RS13920	COG2378	regulation of single-species biofilm formation
AS53_RS13925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AS53_RS13930	COG5002	protein histidine kinase activity
AS53_RS13945	COG0659	secondary active sulfate transmembrane transporter activity
AS53_RS13960	COG0747	negative chemotaxis
AS53_RS13970	COG0601	transmembrane transport
AS53_RS13975	COG4608	Belongs to the ABC transporter superfamily
AS53_RS13985	COG2271	Major facilitator Superfamily
AS53_RS13990	COG1846	Transcriptional regulator
AS53_RS13995	COG0477	Major facilitator Superfamily
AS53_RS14000	COG0477	Major facilitator Superfamily
AS53_RS14005	COG1609	Transcriptional regulator
AS53_RS14010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS53_RS14025	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS53_RS14030	COG1879	ABC-type sugar transport system periplasmic component
AS53_RS14055	COG1063	alcohol dehydrogenase
AS53_RS14070	COG3568	Endonuclease Exonuclease Phosphatase
AS53_RS14095	COG1968	undecaprenyl-diphosphatase activity
AS53_RS14100	COG0840	transmembrane signaling receptor activity
AS53_RS14105	COG3584	3D domain protein
AS53_RS14105	COG1388	LysM domain
AS53_RS14110	COG1476	TRANSCRIPTIONal
AS53_RS14125	COG3104	oligopeptide transport
AS53_RS14130	COG1114	Component of the transport system for branched-chain amino acids
AS53_RS14145	COG1113	amino acid transport
AS53_RS14150	COG2252	PERMEase
AS53_RS14175	COG0569	domain protein
AS53_RS14175	COG0475	glutathione-regulated potassium exporter activity
AS53_RS14190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AS53_RS14195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AS53_RS14200	COG0833	amino acid
AS53_RS14205	COG4990	cell redox homeostasis
AS53_RS14220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS53_RS14225	COG0697	spore germination
AS53_RS14230	COG0531	amino acid
AS53_RS14245	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS53_RS14250	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS53_RS14255	COG1918	ferrous iron import across plasma membrane
AS53_RS14255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS53_RS14260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AS53_RS14265	COG0573	inorganic phosphate transmembrane transporter activity
AS53_RS14270	COG0581	inorganic phosphate transmembrane transporter activity
AS53_RS14280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS53_RS14345	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AS53_RS14370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS53_RS14375	COG1116	anion transmembrane transporter activity
AS53_RS14380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS53_RS14385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS53_RS14390	COG0352	thiamine-phosphate diphosphorylase activity
AS53_RS14395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS53_RS14400	COG2104	thiamine diphosphate biosynthetic process
AS53_RS14410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS53_RS14415	COG0351	phosphomethylpyrimidine kinase
AS53_RS14455	COG2205	protein histidine kinase activity
AS53_RS14460	COG2814	Major facilitator Superfamily
AS53_RS14465	COG1846	Transcriptional regulator
AS53_RS14480	COG2252	PERMEase
AS53_RS14485	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS14500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS53_RS14505	COG1621	beta-fructofuranosidase activity
AS53_RS14510	COG1263	PTS System
AS53_RS14510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_RS14515	COG1609	Transcriptional regulator
AS53_RS14525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS53_RS14530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AS53_RS14570	COG0778	Nitroreductase
AS53_RS14575	COG2719	SpoVR family
AS53_RS14600	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS53_RS14605	COG1937	Protein conserved in bacteria
AS53_RS14610	COG0425	Belongs to the sulfur carrier protein TusA family
AS53_RS14610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_RS14615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_RS14615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_RS14620	COG0425	Belongs to the sulfur carrier protein TusA family
AS53_RS14625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_RS14635	COG2210	Belongs to the sulfur carrier protein TusA family
AS53_RS14640	COG0730	response to heat
AS53_RS14650	COG1316	TRANSCRIPTIONal
AS53_RS14655	COG0604	alcohol dehydrogenase
AS53_RS14660	COG1283	sodium-dependent phosphate transmembrane transporter activity
AS53_RS14675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS53_RS14675	COG3711	transcriptional antiterminator
AS53_RS14680	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS53_RS14685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS53_RS14705	COG1388	LysM domain
AS53_RS14705	COG3584	3D domain protein
AS53_RS14710	COG0577	efflux transmembrane transporter activity
AS53_RS14715	COG1136	(ABC) transporter
AS53_RS14725	COG5522	Integral membrane protein (intg_mem_TP0381)
AS53_RS14740	COG1114	Component of the transport system for branched-chain amino acids
AS53_RS14745	COG3546	catalase activity
AS53_RS14780	COG0586	Pfam SNARE associated Golgi protein
AS53_RS14815	COG0531	amino acid
AS53_RS14820	COG0475	glutathione-regulated potassium exporter activity
AS53_RS14830	COG1737	Transcriptional regulator
AS53_RS14840	COG1263	PTS System
AS53_RS14840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS53_RS14850	COG2259	Doxx family
AS53_RS14865	COG0697	spore germination
AS53_RS14870	COG1522	sequence-specific DNA binding
AS53_RS14885	COG2076	Multidrug Resistance protein
AS53_RS14890	COG1309	transcriptional regulator
AS53_RS14895	COG2814	Major facilitator Superfamily
AS53_RS14900	COG1733	regulation of RNA biosynthetic process
AS53_RS14910	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS53_RS14915	COG4533	DNA binding
AS53_RS14920	COG2211	Major facilitator Superfamily
AS53_RS14930	COG0693	protein deglycase activity
AS53_RS14935	COG0753	catalase activity
AS53_RS14935	COG0693	protein deglycase activity
AS53_RS14945	COG0531	amino acid
AS53_RS14950	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AS53_RS14960	COG1012	belongs to the aldehyde dehydrogenase family
AS53_RS14970	COG1132	(ABC) transporter
AS53_RS14980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS53_RS14985	COG0765	amino acid transport
AS53_RS14990	COG1126	abc transporter atp-binding protein
AS53_RS15005	COG0189	ligase activity
AS53_RS15035	COG0028	Belongs to the TPP enzyme family
AS53_RS15040	COG3527	Alpha-acetolactate decarboxylase
AS53_RS15055	COG0561	phosphatase activity
AS53_RS15070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS53_RS15085	COG0659	secondary active sulfate transmembrane transporter activity
AS53_RS15105	COG0653	protein targeting
AS53_RS15110	COG2244	polysaccharide biosynthetic process
AS53_RS15120	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS53_RS15125	COG4196	transglutaminase domain protein
AS53_RS15140	COG1696	Membrane protein involved in D-alanine export
AS53_RS15155	COG1024	Enoyl-CoA hydratase
AS53_RS15175	COG1363	Peptidase, m42
AS53_RS15195	COG3938	Belongs to the proline racemase family
AS53_RS15235	COG0601	transmembrane transport
AS53_RS15240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS53_RS15250	COG4608	Belongs to the ABC transporter superfamily
AS53_RS15255	COG0322	excinuclease ABC activity
AS53_RS15285	COG0477	Major facilitator Superfamily
AS53_RS15290	COG3290	protein histidine kinase activity
AS53_RS15295	COG4565	transcriptional regulatory protein
AS53_RS15300	COG3181	Tripartite tricarboxylate transporter family receptor
AS53_RS15330	COG4978	Transcriptional regulator
AS53_RS15330	COG0789	Transcriptional regulator
AS53_RS15345	COG0305	Participates in initiation and elongation during chromosome replication
AS53_RS15385	COG0477	Major facilitator Superfamily
AS53_RS15435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS53_RS15435	COG3320	Male sterility
AS53_RS15440	COG1309	transcriptional regulator
AS53_RS15460	COG1183	phosphatidylcholine synthase activity
AS53_RS15480	COG2376	Dihydroxyacetone kinase
AS53_RS15495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS53_RS15500	COG1959	2 iron, 2 sulfur cluster binding
AS53_RS15525	COG3437	response regulator, receiver
AS53_RS15525	COG2770	Histidine kinase
AS53_RS15575	COG3237	CsbD-like
AS53_RS15600	COG1191	sigma factor activity
AS53_RS15610	COG2208	phosphoserine phosphatase activity
AS53_RS15615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AS53_RS15620	COG2205	protein histidine kinase activity
AS53_RS15620	COG0784	Response regulator, receiver
AS53_RS15620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS53_RS15620	COG2198	Histidine kinase
AS53_RS15680	COG0420	3'-5' exonuclease activity
AS53_RS15685	COG4717	serine-type aminopeptidase activity
AS53_RS15705	COG1309	transcriptional regulator
AS53_RS15710	COG2814	Major facilitator Superfamily
AS53_RS15715	COG0346	lactoylglutathione lyase activity
AS53_RS15720	COG0346	lactoylglutathione lyase activity
AS53_RS15725	COG0457	Tetratricopeptide repeat
AS53_RS15730	COG2267	carboxylic ester hydrolase activity
AS53_RS15750	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AS53_RS15755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS53_RS15765	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AS53_RS15805	COG0477	Major facilitator Superfamily
AS53_RS15810	COG0477	Major facilitator Superfamily
AS53_RS15820	COG3973	AAA domain
AS53_RS15850	COG4980	gas vesicle protein
AS53_RS15855	COG0537	adenosine 5'-monophosphoramidase activity
AS53_RS15860	COG1131	(ABC) transporter
AS53_RS15865	COG4473	ABC transporter
AS53_RS15875	COG1309	transcriptional regulator
AS53_RS15885	COG3402	PFAM membrane-flanked domain
AS53_RS15895	COG3428	Bacterial PH domain
AS53_RS15935	COG3402	PFAM membrane-flanked domain
AS53_RS15940	COG3428	Bacterial PH domain
AS53_RS15945	COG2329	Antibiotic biosynthesis monooxygenase
AS53_RS15950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS53_RS15955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AS53_RS15960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AS53_RS15965	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AS53_RS16000	COG1309	transcriptional regulator
AS53_RS16005	COG1511	domain protein
AS53_RS16030	COG1609	Transcriptional regulator
AS53_RS16040	COG1234	tRNA 3'-trailer cleavage
AS53_RS16045	COG0095	Lipoate-protein ligase
AS53_RS16055	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_RS16085	COG3209	COG3209 Rhs family protein
AS53_RS16130	COG1408	metallophosphoesterase
AS53_RS16135	COG1078	dGTPase activity
AS53_RS16145	COG1595	DNA-templated transcription, initiation
AS53_RS16150	COG2207	Transcriptional regulator
AS53_RS16150	COG3708	Transcriptional regulator
AS53_RS16165	COG2205	protein histidine kinase activity
AS53_RS16170	COG0745	RESPONSE REGULATOR receiver
AS53_RS16195	COG0501	Belongs to the peptidase M48B family
AS53_RS16200	COG0840	transmembrane signaling receptor activity
AS53_RS16205	COG0697	spore germination
AS53_RS16225	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AS53_RS16230	COG2224	Isocitrate lyase
AS53_RS16255	COG4903	ComK protein
AS53_RS16260	COG0398	Pfam SNARE associated Golgi protein
AS53_RS16270	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AS53_RS16275	COG1074	ATP-dependent DNA helicase activity
AS53_RS16320	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS53_RS16345	COG0367	asparagine synthase
AS53_RS16350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AS53_RS16355	COG0753	catalase activity
AS53_RS16360	COG0004	ammonium transporteR
AS53_RS16385	COG2996	Protein conserved in bacteria
AS53_RS16395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS53_RS16405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_RS16420	COG0561	phosphatase activity
AS53_RS16435	COG0542	response to heat
AS53_RS16445	COG2267	carboxylic ester hydrolase activity
AS53_RS16460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_RS16465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AS53_RS16470	COG5504	Zn-dependent protease
AS53_RS16480	COG0180	Tryptophanyl-tRNA synthetase
AS53_RS16490	COG4166	transmembrane transport
AS53_RS16495	COG0601	transmembrane transport
AS53_RS16500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS53_RS16505	COG0444	Belongs to the ABC transporter superfamily
AS53_RS16510	COG4608	Belongs to the ABC transporter superfamily
AS53_RS16515	COG0534	Mate efflux family protein
AS53_RS16520	COG4166	transmembrane transport
AS53_RS16540	COG0861	Integral membrane protein TerC family
AS53_RS16545	COG4862	establishment of competence for transformation
AS53_RS16550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS53_RS16560	COG1164	Oligoendopeptidase f
AS53_RS16570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AS53_RS16575	COG2346	COG2346, Truncated hemoglobins
AS53_RS16580	COG4116	CYTH
AS53_RS16590	COG2357	RelA SpoT domain protein
AS53_RS16600	COG0564	pseudouridine synthase activity
AS53_RS16615	COG0772	Belongs to the SEDS family
AS53_RS16620	COG1216	Glycosyl transferase, family 2
AS53_RS16620	COG0463	Glycosyl transferase, family 2
AS53_RS16640	COG0463	Glycosyl transferase, family 2
AS53_RS16640	COG0457	Tetratricopeptide repeat
AS53_RS16660	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AS53_RS16675	COG1091	dTDP-4-dehydrorhamnose reductase activity
AS53_RS16720	COG2153	protein acetylation
AS53_RS16730	COG2382	esterase
AS53_RS16745	COG5492	domain, Protein
AS53_RS16750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS53_RS16765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS53_RS16765	COG0512	Glutamine amidotransferase of anthranilate synthase
AS53_RS16800	COG1620	l-lactate permease
AS53_RS16805	COG5634	Uncharacterized conserved protein (DUF2278)
AS53_RS16855	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS53_RS16865	COG1476	TRANSCRIPTIONal
AS53_RS16925	COG2226	methyltransferase
AS53_RS16935	COG1686	Belongs to the peptidase S11 family
AS53_RS16940	COG0681	Belongs to the peptidase S26 family
AS53_RS16975	COG1012	belongs to the aldehyde dehydrogenase family
AS53_RS16980	COG3842	ATPase activity
AS53_RS16985	COG1176	ABC-type spermidine putrescine transport system, permease component I
AS53_RS16990	COG1177	transmembrane transport
AS53_RS16995	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AS53_RS17005	COG2409	Drug exporters of the RND superfamily
AS53_RS17015	COG0564	pseudouridine synthase activity
AS53_RS17025	COG2340	Cysteine-rich secretory protein family
AS53_RS17030	COG0247	lactate metabolic process
AS53_RS17035	COG0277	FAD linked oxidase domain protein
AS53_RS17040	COG3835	regulator
AS53_RS17050	COG0745	RESPONSE REGULATOR receiver
AS53_RS17055	COG5002	protein histidine kinase activity
AS53_RS17060	COG2186	Transcriptional regulator
AS53_RS17080	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AS53_RS17090	COG2116	formate transmembrane transporter activity
AS53_RS17095	COG0861	Integral membrane protein TerC family
AS53_RS17100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS53_RS17110	COG2030	dehydratase
AS53_RS17130	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS17135	COG3243	poly(R)-hydroxyalkanoic acid synthase
AS53_RS17140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS53_RS17145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS53_RS17160	COG1840	ABC-type Fe3 transport system, periplasmic component
AS53_RS17190	COG1349	DNA-binding transcription factor activity
AS53_RS17215	COG2861	carbohydrate metabolic process
AS53_RS17225	COG3852	Histidine kinase
AS53_RS17230	COG1846	Transcriptional regulator
AS53_RS17240	COG2318	DinB family
AS53_RS17250	COG5002	protein histidine kinase activity
AS53_RS17260	COG0720	synthase
AS53_RS17275	COG4873	Protein conserved in bacteria
AS53_RS17310	COG1780	Probably involved in ribonucleotide reductase function
AS53_RS17325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS53_RS17330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS53_RS17335	COG1725	Transcriptional regulator
AS53_RS17340	COG1131	(ABC) transporter
AS53_RS17350	COG1131	(ABC) transporter
AS53_RS17355	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS53_RS17370	COG1522	sequence-specific DNA binding
AS53_RS17380	COG1335	isochorismatase
AS53_RS17390	COG1619	proteins homologs of microcin C7 resistance protein MccF
AS53_RS17395	COG2070	2-Nitropropane dioxygenase
AS53_RS17400	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AS53_RS17410	COG1696	Membrane protein involved in D-alanine export
AS53_RS17435	COG0716	FMN binding
AS53_RS17450	COG3173	Aminoglycoside phosphotransferase
AS53_RS17470	COG0534	Mate efflux family protein
AS53_RS17475	COG1968	undecaprenyl-diphosphatase activity
AS53_RS17490	COG1846	Transcriptional regulator
AS53_RS17500	COG1301	dicarboxylic acid transport
AS53_RS17505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS53_RS17510	COG4709	membrane
AS53_RS17515	COG3874	Sporulation protein YtfJ
AS53_RS17545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS53_RS17550	COG0028	Belongs to the TPP enzyme family
AS53_RS17555	COG0440	acetolactate synthase activity
AS53_RS17560	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AS53_RS17570	COG0473	3-isopropylmalate dehydrogenase activity
AS53_RS17595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AS53_RS17630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AS53_RS17645	COG1183	phosphatidylcholine synthase activity
AS53_RS17650	COG1368	sulfuric ester hydrolase activity
AS53_RS17660	COG0019	diaminopimelate decarboxylase activity
AS53_RS17680	COG0529	Catalyzes the synthesis of activated sulfate
AS53_RS17685	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS53_RS17705	COG1648	precorrin-2 dehydrogenase activity
AS53_RS17715	COG0733	neurotransmitter:sodium symporter activity
AS53_RS17735	COG1757	Na H antiporter
AS53_RS17750	COG4758	membrane
AS53_RS17755	COG4585	Histidine kinase
AS53_RS17760	COG2197	response regulator
AS53_RS17770	COG1114	Component of the transport system for branched-chain amino acids
AS53_RS17780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AS53_RS17805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS53_RS17805	COG1017	nitric oxide dioxygenase activity
AS53_RS17825	COG0730	response to heat
AS53_RS17830	COG0306	phosphate transporter
AS53_RS17835	COG1392	Phosphate transport regulator
AS53_RS17840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS53_RS17855	COG3852	Histidine kinase
AS53_RS17860	COG1801	Protein of unknown function DUF72
AS53_RS17870	COG0582	viral genome integration into host DNA
AS53_RS17875	COG5002	protein histidine kinase activity
AS53_RS17895	COG0392	lysyltransferase activity
AS53_RS17895	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AS53_RS17910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AS53_RS17915	COG1686	Belongs to the peptidase S11 family
AS53_RS17920	COG2715	membrane protein required for spore maturation
AS53_RS17925	COG0700	Nucleoside recognition
AS53_RS17930	COG1187	pseudouridine synthase activity
AS53_RS17940	COG1333	cytochrome c biogenesis protein
AS53_RS17945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS53_RS17950	COG0745	RESPONSE REGULATOR receiver
AS53_RS17955	COG5002	protein histidine kinase activity
AS53_RS17960	COG2096	Adenosyltransferase
AS53_RS17975	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AS53_RS17980	COG1141	Ferredoxin
AS53_RS17985	COG4955	Helix-turn-helix domain
AS53_RS17990	COG0514	ATP-dependent DNA helicase (RecQ)
AS53_RS17995	COG1266	CAAX protease self-immunity
AS53_RS18015	COG4862	establishment of competence for transformation
AS53_RS18020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS53_RS18040	COG0492	ferredoxin-NADP+ reductase activity
AS53_RS18045	COG0252	asparaginase activity
AS53_RS18115	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AS53_RS18130	COG0142	geranyltranstransferase activity
AS53_RS18140	COG0142	geranyltranstransferase activity
AS53_RS18160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS53_RS18165	COG0457	Tetratricopeptide repeat
AS53_RS18185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AS53_RS18195	COG4347	Protein of unknown function (DUF1405)
AS53_RS18210	COG2738	Putative neutral zinc metallopeptidase
AS53_RS18220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_RS18225	COG1694	Mazg nucleotide pyrophosphohydrolase
AS53_RS18240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS53_RS18245	COG0438	transferase activity, transferring glycosyl groups
AS53_RS18285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AS53_RS18285	COG1199	ATP-dependent helicase activity
AS53_RS18305	COG3935	DnaD domain protein
AS53_RS18310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AS53_RS18320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS53_RS18320	COG4499	WXG100 protein secretion system (Wss), protein YukC
AS53_RS18370	COG0116	Belongs to the methyltransferase superfamily
AS53_RS18380	COG1199	ATP-dependent helicase activity
AS53_RS18385	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AS53_RS18395	COG3173	Aminoglycoside phosphotransferase
AS53_RS18400	COG0024	Methionine aminopeptidase
AS53_RS18410	COG2233	PERMEase
AS53_RS18415	COG2311	Membrane
AS53_RS18420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AS53_RS18430	COG0456	acetyltransferase
AS53_RS18455	COG0754	glutathionylspermidine amidase activity
AS53_RS18470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS53_RS18495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AS53_RS18510	COG1215	transferase activity, transferring glycosyl groups
AS53_RS18515	COG0438	transferase activity, transferring glycosyl groups
AS53_RS18530	COG0454	-acetyltransferase
AS53_RS18550	COG0328	RNA-DNA hybrid ribonuclease activity
AS53_RS18590	COG1280	lysine exporter protein (LysE YggA)
AS53_RS18605	COG3162	membrane
AS53_RS18610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS53_RS18615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS53_RS18625	COG0475	glutathione-regulated potassium exporter activity
AS53_RS18630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS53_RS18635	COG0789	Transcriptional regulator
AS53_RS18635	COG4978	Transcriptional regulator
AS53_RS18645	COG2323	membrane
AS53_RS18650	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AS53_RS18705	COG1923	regulation of RNA biosynthetic process
AS53_RS18715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AS53_RS18720	COG1360	Flagellar Motor Protein
AS53_RS18725	COG2201	protein-glutamate methylesterase activity
AS53_RS18735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS53_RS18735	COG1776	CheC inhibitor of MCP methylation
AS53_RS18750	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AS53_RS18770	COG1256	bacterial-type flagellum assembly
AS53_RS18775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AS53_RS18800	COG1815	bacterial-type flagellum-dependent cell motility
AS53_RS18805	COG1558	bacterial-type flagellum-dependent cell motility
AS53_RS18815	COG1766	The M ring may be actively involved in energy transduction
AS53_RS18825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS53_RS18835	COG1157	protein secretion by the type III secretion system
AS53_RS18875	COG0835	chemotaxis
AS53_RS18875	COG0784	Response regulator, receiver
AS53_RS18885	COG0463	Glycosyl transferase, family 2
AS53_RS18915	COG0463	Glycosyl transferase, family 2
AS53_RS18915	COG0457	Tetratricopeptide repeat
AS53_RS18940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AS53_RS18945	COG0741	lytic transglycosylase activity
AS53_RS18960	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS53_RS18960	COG1776	CheC inhibitor of MCP methylation
AS53_RS18970	COG1338	Plays a role in the flagellum-specific transport system
AS53_RS18975	COG1987	bacterial-type flagellum assembly
AS53_RS18985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AS53_RS18990	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AS53_RS18995	COG1419	protein localization to endoplasmic reticulum
AS53_RS19000	COG4786	Flagellar basal body rod
AS53_RS19005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AS53_RS19030	COG1309	transcriptional regulator
AS53_RS19050	COG2329	Antibiotic biosynthesis monooxygenase
AS53_RS19075	COG0583	DNA-binding transcription factor activity
AS53_RS19080	COG3842	ATPase activity
AS53_RS19085	COG0725	ABC transporter, periplasmic molybdate-binding protein
AS53_RS19095	COG1234	tRNA 3'-trailer cleavage
AS53_RS19120	COG1686	Belongs to the peptidase S11 family
AS53_RS19130	COG0406	alpha-ribazole phosphatase activity
AS53_RS19160	COG0367	asparagine synthase
AS53_RS19190	COG1802	Transcriptional regulator
AS53_RS19195	COG0697	spore germination
AS53_RS19200	COG0523	cobalamin synthesis protein
AS53_RS19205	COG0701	Predicted permease
AS53_RS19215	COG0438	transferase activity, transferring glycosyl groups
AS53_RS19215	COG1216	Glycosyl transferase, family 2
AS53_RS19220	COG1757	Na H antiporter
AS53_RS19225	COG0114	fumarate hydratase activity
AS53_RS19275	COG0785	Cytochrome C biogenesis protein
AS53_RS19310	COG2733	membrane
AS53_RS19345	COG1131	(ABC) transporter
AS53_RS19360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS53_RS19365	COG0528	UMP kinase activity
AS53_RS19375	COG1027	Aspartate ammonia-lyase
AS53_RS19380	COG0281	malic enzyme
AS53_RS19385	COG4191	Histidine kinase
AS53_RS19390	COG0784	Response regulator, receiver
AS53_RS19395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS53_RS19455	COG1051	belongs to the nudix hydrolase family
AS53_RS19460	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS53_RS19470	COG2814	Major facilitator Superfamily
AS53_RS19485	COG1966	Carbon starvation protein
AS53_RS19500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_RS19510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AS53_RS19520	COG4166	transmembrane transport
AS53_RS19525	COG2223	nitrite transmembrane transporter activity
AS53_RS19530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS53_RS19545	COG2244	polysaccharide biosynthetic process
AS53_RS19550	COG0733	neurotransmitter:sodium symporter activity
AS53_RS19560	COG5566	PFAM Mor transcription activator
AS53_RS19565	COG2323	membrane
AS53_RS19580	COG2084	Dehydrogenase
AS53_RS19595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS53_RS19605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS53_RS19610	COG0028	Belongs to the TPP enzyme family
AS53_RS19615	COG0440	acetolactate synthase activity
AS53_RS19620	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AS53_RS19630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AS53_RS19655	COG2814	Major facilitator Superfamily
AS53_RS19660	COG3384	dioxygenase
AS53_RS19670	COG3279	Response regulator of the LytR AlgR family
AS53_RS19675	COG0427	acetyl-CoA hydrolase
AS53_RS19695	COG1073	alpha beta
AS53_RS19700	COG4166	transmembrane transport
AS53_RS19725	COG0535	radical SAM domain protein
AS53_RS19730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_RS19750	COG1914	H( )-stimulated, divalent metal cation uptake system
AS53_RS19765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AS53_RS19800	COG2390	Transcriptional regulator
AS53_RS19810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_RS19815	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AS53_RS19830	COG4224	UPF0291 protein
AS53_RS19850	COG0006	proline dipeptidase activity
AS53_RS19855	COG2132	Multicopper oxidase
AS53_RS19870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS53_RS19885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS53_RS19900	COG2372	response to copper ion
AS53_RS19900	COG1276	copper resistance
AS53_RS19905	COG4549	nuclear export factor GLE1
AS53_RS19915	COG0697	spore germination
AS53_RS19920	COG0583	DNA-binding transcription factor activity
AS53_RS19925	COG1959	2 iron, 2 sulfur cluster binding
AS53_RS19930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AS53_RS19935	COG0778	Nitroreductase
AS53_RS19950	COG0628	permease
AS53_RS19960	COG1231	oxidoreductase activity
AS53_RS19965	COG0523	cobalamin synthesis protein
AS53_RS19980	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_RS19985	COG2030	dehydratase
AS53_RS19990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_RS20000	COG0411	ABC transporter
AS53_RS20020	COG0583	DNA-binding transcription factor activity
AS53_RS20030	COG1942	4-Oxalocrotonate Tautomerase
AS53_RS20040	COG1846	Transcriptional regulator
AS53_RS20050	COG1271	oxidase subunit
AS53_RS20055	COG1294	oxidase, subunit
AS53_RS20060	COG4988	ABC transporter
AS53_RS20065	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AS53_RS20085	COG1686	Belongs to the peptidase S11 family
AS53_RS20100	COG1388	LysM domain
AS53_RS20100	COG0791	NLP P60 protein
AS53_RS20110	COG1132	(ABC) transporter
AS53_RS20115	COG1132	(ABC) transporter
AS53_RS20120	COG0745	RESPONSE REGULATOR receiver
AS53_RS20125	COG5002	protein histidine kinase activity
AS53_RS20170	COG0460	homoserine dehydrogenase
AS53_RS20195	COG1316	TRANSCRIPTIONal
AS53_RS20205	COG0745	RESPONSE REGULATOR receiver
AS53_RS20210	COG5002	protein histidine kinase activity
AS53_RS20225	COG1285	pathogenesis
AS53_RS20230	COG1247	-acetyltransferase
AS53_RS20250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS53_RS20260	COG1082	Xylose isomerase domain protein TIM barrel
AS53_RS20275	COG1279	arginine transmembrane transporter activity
AS53_RS20285	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS53_RS20325	COG2002	toxin-antitoxin pair type II binding
AS53_RS20330	COG1404	Belongs to the peptidase S8 family
AS53_RS20335	COG0640	Transcriptional regulator
AS53_RS20340	COG0667	Aldo Keto reductase
AS53_RS20345	COG2814	Major facilitator Superfamily
AS53_RS20370	COG0840	transmembrane signaling receptor activity
AS53_RS20390	COG3949	Membrane
AS53_RS20395	COG0783	Belongs to the Dps family
AS53_RS20410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS53_RS20420	COG1231	oxidoreductase activity
AS53_RS20430	COG4989	oxidoreductase activity
AS53_RS20435	COG0523	cobalamin synthesis protein
AS53_RS20440	COG0456	acetyltransferase
AS53_RS20500	COG3443	Belongs to the bacterial solute-binding protein 9 family
AS53_RS20500	COG0803	Belongs to the bacterial solute-binding protein 9 family
AS53_RS20510	COG0702	epimerase
AS53_RS20520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS53_RS20530	COG4166	transmembrane transport
AS53_RS20545	COG0406	alpha-ribazole phosphatase activity
AS53_RS20555	COG5337	Spore coat protein CotH
AS53_RS20560	COG1051	belongs to the nudix hydrolase family
AS53_RS20565	COG0586	Pfam SNARE associated Golgi protein
AS53_RS20570	COG2244	polysaccharide biosynthetic process
AS53_RS20580	COG0701	Predicted permease
AS53_RS20585	COG3689	TIGRFAM TIGR03943 family protein
AS53_RS20590	COG1607	acyl-coa hydrolase
AS53_RS20595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS53_RS20610	COG0702	epimerase
AS53_RS20615	COG2839	Protein conserved in bacteria
AS53_RS20620	COG1253	flavin adenine dinucleotide binding
AS53_RS20635	COG1114	Component of the transport system for branched-chain amino acids
AS53_RS20640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS53_RS20660	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS53_RS20670	COG1876	peptidase activity
AS53_RS20680	COG0154	amidase activity
AS53_RS20685	COG2211	Major facilitator Superfamily
AS53_RS20705	COG0561	phosphatase activity
AS53_RS20715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS53_RS20720	COG4106	trans-aconitate 2-methyltransferase activity
AS53_RS20735	COG1819	glycosyl
AS53_RS20740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_RS20745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_RS20770	COG0456	acetyltransferase
AS53_RS20820	COG3874	Sporulation protein YtfJ
AS53_RS20845	COG2226	methyltransferase
AS53_RS20865	COG1082	Xylose isomerase domain protein TIM barrel
AS53_RS20870	COG0346	lactoylglutathione lyase activity
AS53_RS20880	COG0604	alcohol dehydrogenase
AS53_RS20885	COG1595	DNA-templated transcription, initiation
AS53_RS20910	COG0386	Belongs to the glutathione peroxidase family
AS53_RS20915	COG1305	Transglutaminase-like
AS53_RS20920	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AS53_RS20925	COG0714	Associated with various cellular activities
AS53_RS20940	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AS53_RS20945	COG1140	nitrate reductase beta subunit
AS53_RS20950	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AS53_RS20955	COG2181	nitrate reductase activity
AS53_RS20975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS53_RS20980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AS53_RS20985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS53_RS20990	COG0303	'Molybdopterin
AS53_RS20995	COG0314	molybdopterin synthase activity
AS53_RS21005	COG2223	nitrite transmembrane transporter activity
AS53_RS21020	COG1648	precorrin-2 dehydrogenase activity
AS53_RS21030	COG1587	Uroporphyrinogen-III synthase
AS53_RS21030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AS53_RS21035	COG2146	nitrite reductase [NAD(P)H] activity
AS53_RS21040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS53_RS21045	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AS53_RS21080	COG2359	stage V sporulation protein S
AS53_RS21095	COG5632	N-Acetylmuramoyl-L-alanine amidase
AS53_RS21110	COG1418	mRNA catabolic process
AS53_RS21115	COG0488	(ABC) transporter
AS53_RS21130	COG0629	single-stranded DNA binding
AS53_RS21145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS53_RS21150	COG1413	lyase activity
AS53_RS21165	COG2521	methyltransferase
AS53_RS21165	COG2136	Putative SAM-dependent methyltransferase
AS53_RS21170	COG0018	arginyl-trna synthetase
AS53_RS21195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AS53_RS21210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AS53_RS21215	COG0017	Asparaginyl-tRNA synthetase
AS53_RS21235	COG1674	ftsk spoiiie
AS53_RS21330	COG1929	Belongs to the glycerate kinase type-1 family
AS53_RS21335	COG0471	metal ion transport
AS53_RS21340	COG0745	RESPONSE REGULATOR receiver
AS53_RS21345	COG5002	protein histidine kinase activity
AS53_RS21345	COG3850	Histidine kinase
AS53_RS21360	COG0733	neurotransmitter:sodium symporter activity
AS53_RS21385	COG2610	gluconate transmembrane transporter activity
AS53_RS21390	COG1454	alcohol dehydrogenase
AS53_RS21395	COG1794	racemase activity, acting on amino acids and derivatives
AS53_RS21405	COG0456	acetyltransferase
AS53_RS21420	COG1131	(ABC) transporter
AS53_RS21425	COG4473	ABC transporter
AS53_RS21435	COG0546	phosphoglycolate phosphatase activity
AS53_RS21455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS53_RS21470	COG0768	penicillin binding
AS53_RS21475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS53_RS21480	COG0204	Acyl-transferase
AS53_RS21485	COG1272	protein, Hemolysin III
AS53_RS21495	COG0805	protein transport
AS53_RS21505	COG1307	EDD domain protein, DegV family
AS53_RS21510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AS53_RS21515	COG1999	signal sequence binding
AS53_RS21520	COG0071	Belongs to the small heat shock protein (HSP20) family
AS53_RS21525	COG0367	asparagine synthase
AS53_RS21545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_RS21550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS53_RS21585	COG0668	transmembrane transport
AS53_RS21590	COG4585	Histidine kinase
AS53_RS21590	COG2203	Gaf domain
AS53_RS21595	COG2197	response regulator
AS53_RS21605	COG1737	Transcriptional regulator
AS53_RS21610	COG1064	alcohol dehydrogenase
AS53_RS21640	COG1070	Carbohydrate kinase
AS53_RS21645	COG1070	Carbohydrate kinase
AS53_RS21675	COG1125	glycine betaine transport
AS53_RS21675	COG0517	IMP dehydrogenase activity
AS53_RS21680	COG1174	glycine betaine transport
AS53_RS21715	COG1253	flavin adenine dinucleotide binding
AS53_RS21720	COG1012	belongs to the aldehyde dehydrogenase family
AS53_RS21725	COG5506	Protein of unknown function (DUF1694)
AS53_RS21740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS53_RS21745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS53_RS21750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS53_RS21755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS53_RS21760	COG0456	acetyltransferase
AS53_RS21765	COG3829	transcription factor binding
AS53_RS21770	COG1509	lysine 2,3-aminomutase activity
AS53_RS21810	COG4326	sporulation control protein
AS53_RS21815	COG0671	phosphoesterase, PA-phosphatase related
AS53_RS21820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AS53_RS21825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS53_RS21855	COG1787	Restriction endonuclease
AS53_RS21855	COG1715	Restriction endonuclease
AS53_RS21945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS53_RS21985	COG4499	WXG100 protein secretion system (Wss), protein YukC
AS53_RS21985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS53_RS21990	COG2814	Major facilitator Superfamily
AS53_RS21995	COG4841	protein insertion into membrane
AS53_RS22000	COG0372	Belongs to the citrate synthase family
AS53_RS22005	COG2079	MmgE PrpD family protein
AS53_RS22010	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AS53_RS22015	COG1960	acyl-CoA dehydrogenase activity
AS53_RS22020	COG2084	Dehydrogenase
AS53_RS22030	COG1280	lysine exporter protein (LysE YggA)
AS53_RS22035	COG1024	Enoyl-CoA hydratase
AS53_RS22050	COG0420	3'-5' exonuclease activity
AS53_RS22055	COG0419	ATPase involved in DNA repair
AS53_RS22085	COG2223	nitrite transmembrane transporter activity
AS53_RS22090	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS22095	COG1169	isochorismate synthase
AS53_RS22100	COG1021	2,3-dihydroxybenzoate-AMP ligase
AS53_RS22105	COG1535	isochorismatase
AS53_RS22105	COG3433	isochorismatase activity
AS53_RS22110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AS53_RS22115	COG3251	PFAM MbtH domain protein
AS53_RS22120	COG2814	Major facilitator Superfamily
AS53_RS22135	COG0776	regulation of translation
AS53_RS22145	COG2318	DinB family
AS53_RS22155	COG1115	amino acid carrier protein
AS53_RS22175	COG2329	Antibiotic biosynthesis monooxygenase
AS53_RS22180	COG1187	pseudouridine synthase activity
AS53_RS22185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS53_RS22200	COG0596	Alpha beta hydrolase
AS53_RS22205	COG2814	Major facilitator Superfamily
AS53_RS22225	COG2226	methyltransferase
AS53_RS22270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_RS22305	COG1247	-acetyltransferase
AS53_RS22335	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AS53_RS22345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_RS22355	COG1278	Cold shock
AS53_RS22370	COG0010	Belongs to the arginase family
AS53_RS22375	COG0561	phosphatase activity
AS53_RS22420	COG0583	DNA-binding transcription factor activity
AS53_RS22425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AS53_RS22440	COG0583	DNA-binding transcription factor activity
AS53_RS22445	COG2258	MOSC domain
AS53_RS22460	COG1132	(ABC) transporter
AS53_RS22465	COG1132	(ABC) transporter
AS53_RS22485	COG1396	sequence-specific DNA binding
AS53_RS22510	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AS53_RS22515	COG1595	DNA-templated transcription, initiation
AS53_RS22540	COG1649	PFAM Uncharacterised BCR, COG1649
AS53_RS22565	COG2971	BadF BadG BcrA BcrD
AS53_RS22570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AS53_RS22575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AS53_RS22595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_RS22625	COG1309	transcriptional regulator
AS53_RS22640	COG0577	efflux transmembrane transporter activity
AS53_RS22640	COG1136	(ABC) transporter
AS53_RS22645	COG3615	Tellurite resistance protein tehB
AS53_RS22645	COG0500	methyltransferase
AS53_RS22655	COG2226	methyltransferase
AS53_RS22660	COG3961	Belongs to the TPP enzyme family
AS53_RS22665	COG1846	Transcriptional regulator
AS53_RS22705	COG2195	Cleaves the N-terminal amino acid of tripeptides
AS53_RS22720	COG1595	DNA-templated transcription, initiation
AS53_RS22730	COG0768	penicillin binding
AS53_RS22740	COG2367	Beta-lactamase
AS53_RS22745	COG0671	phosphoesterase, PA-phosphatase related
AS53_RS22750	COG1609	Transcriptional regulator
AS53_RS22755	COG2814	Major facilitator Superfamily
AS53_RS22760	COG0673	inositol 2-dehydrogenase activity
AS53_RS22770	COG1012	belongs to the aldehyde dehydrogenase family
AS53_RS22785	COG0191	fructose-bisphosphate aldolase activity
AS53_RS22790	COG3718	enzyme involved in inositol metabolism
AS53_RS22820	COG0457	Tetratricopeptide repeat
AS53_RS22825	COG1476	TRANSCRIPTIONal
AS53_RS22840	COG1876	peptidase activity
AS53_RS22860	COG1309	transcriptional regulator
AS53_RS22865	COG0488	(ABC) transporter
AS53_RS22880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_RS22890	COG1252	NADH dehydrogenase
AS53_RS22895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS53_RS22910	COG1131	(ABC) transporter
AS53_RS22920	COG1309	transcriptional regulator
AS53_RS22935	COG1960	acyl-CoA dehydrogenase activity
AS53_RS22940	COG0439	Biotin carboxylase
AS53_RS22945	COG0511	ligase activity, forming carbon-carbon bonds
AS53_RS22950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS53_RS22955	COG1024	Enoyl-CoA hydratase
AS53_RS22960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS53_RS22965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS53_RS22975	COG1247	-acetyltransferase
AS53_RS22980	COG0572	uridine kinase
AS53_RS22990	COG2318	DinB family
AS53_RS22995	COG1686	Belongs to the peptidase S11 family
AS53_RS23020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AS53_RS23060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AS53_RS23060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AS53_RS23085	COG2814	Major facilitator Superfamily
AS53_RS23105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS53_RS23125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_RS23140	COG1063	alcohol dehydrogenase
AS53_RS23155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS53_RS23160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS53_RS23175	COG3773	Cell wall hydrolase
AS53_RS23185	COG0745	RESPONSE REGULATOR receiver
AS53_RS23200	COG0488	(ABC) transporter
AS53_RS23215	COG1136	(ABC) transporter
AS53_RS23240	COG0460	homoserine dehydrogenase
AS53_RS23245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_RS23255	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS53_RS23330	COG2124	cytochrome p450
AS53_RS23365	COG0561	phosphatase activity
AS53_RS23375	COG5002	protein histidine kinase activity
AS53_RS23380	COG0768	penicillin binding
AS53_RS23385	COG1819	glycosyl
AS53_RS23390	COG1794	racemase activity, acting on amino acids and derivatives
AS53_RS23400	COG1122	ATPase activity
AS53_RS23410	COG2205	protein histidine kinase activity
AS53_RS23420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS53_RS23425	COG0604	alcohol dehydrogenase
AS53_RS23430	COG0768	penicillin binding
AS53_RS23440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS53_RS23475	COG0693	protein deglycase activity
AS53_RS23505	COG2814	Major facilitator Superfamily
AS53_RS23520	COG0584	glycerophosphoryl diester phosphodiesterase
AS53_RS23540	COG0697	spore germination
AS53_RS23565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS53_RS23575	COG2223	nitrite transmembrane transporter activity
AS53_RS23590	COG2816	NAD+ diphosphatase activity
AS53_RS23595	COG0592	DNA-directed DNA polymerase activity
AS53_RS23600	COG1051	belongs to the nudix hydrolase family
AS53_RS23635	COG3878	Protein conserved in bacteria
AS53_RS23665	COG4667	esterase of the alpha-beta hydrolase superfamily
AS53_RS23690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS53_RS23705	COG0322	excinuclease ABC activity
AS53_RS23745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS53_RS23770	COG1011	Hydrolase
AS53_RS23790	COG0076	glutamate decarboxylase activity
AS53_RS23805	COG1523	belongs to the glycosyl hydrolase 13 family
AS53_RS23810	COG3227	Zinc metalloprotease (Elastase)
AS53_RS23830	COG0201	protein transport
AS53_RS23840	COG0697	spore germination
AS53_RS23845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_RS23875	COG4129	membrane
AS53_RS23880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_RS23895	COG2959	enzyme of heme biosynthesis
AS53_RS23915	COG3483	tryptophan 2,3-dioxygenase activity
AS53_RS23920	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AS53_RS23925	COG3844	kynureninase activity
AS53_RS23930	COG1309	transcriptional regulator
AS53_RS23960	COG3284	Transcriptional regulator
AS53_RS23980	COG1349	DNA-binding transcription factor activity
AS53_RS24000	COG1959	2 iron, 2 sulfur cluster binding
AS53_RS24015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS53_RS24020	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS53_RS24025	COG0022	dehydrogenase e1 component
AS53_RS24030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS53_RS24040	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS24045	COG0456	acetyltransferase
AS53_RS24045	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS53_RS24080	COG4176	ABC-type proline glycine betaine transport system permease component
AS53_RS24085	COG4175	Glycine betaine
AS53_RS24085	COG0517	IMP dehydrogenase activity
AS53_RS24110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AS53_RS24115	COG2153	protein acetylation
AS53_RS24120	COG3397	chitin binding
AS53_RS24135	COG2205	protein histidine kinase activity
AS53_RS24165	COG0658	competence protein
AS53_RS24165	COG2333	competence protein COMEC
AS53_RS24215	COG3973	AAA domain
AS53_RS24230	COG2105	PFAM AIG2 family protein
AS53_RS24235	COG0514	ATP-dependent DNA helicase (RecQ)
AS53_RS24265	COG4637	Psort location Cytoplasmic, score
AS53_RS24290	COG3397	chitin binding
AS53_RS24300	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS53_RS24305	COG1115	amino acid carrier protein
AS53_RS24310	COG1012	belongs to the aldehyde dehydrogenase family
AS53_RS24315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS53_RS24325	COG3938	Belongs to the proline racemase family
AS53_RS24330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS53_RS24370	COG0586	Pfam SNARE associated Golgi protein
AS53_RS24385	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AS53_RS24390	COG0519	Catalyzes the synthesis of GMP from XMP
AS53_RS24395	COG4166	transmembrane transport
AS53_RS24405	COG4948	Mandelate Racemase Muconate Lactonizing
AS53_RS24445	COG2936	dipeptidyl-peptidase activity
AS53_RS24450	COG5002	protein histidine kinase activity
AS53_RS24455	COG0745	RESPONSE REGULATOR receiver
AS53_RS24495	COG1307	EDD domain protein, DegV family
AS53_RS24515	COG2814	Major facilitator Superfamily
AS53_RS24525	COG1664	Polymer-forming cytoskeletal
AS53_RS24530	COG0789	Transcriptional regulator
AS53_RS24535	COG4533	DNA binding
AS53_RS24540	COG0477	Major facilitator Superfamily
AS53_RS24540	COG2814	Major facilitator Superfamily
AS53_RS24560	COG2261	transglycosylase associated protein
AS53_RS24575	COG2226	methyltransferase
AS53_RS24610	COG0436	Aminotransferase
AS53_RS24615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AS53_RS24620	COG5146	pantothenate kinase activity
AS53_RS24640	COG1131	(ABC) transporter
AS53_RS24690	COG0628	permease
AS53_RS24705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS53_RS24710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS53_RS24715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS53_RS24720	COG1116	anion transmembrane transporter activity
AS53_RS24740	COG2816	NAD+ diphosphatase activity
AS53_RS24760	COG2746	aminoglycoside 3-N-acetyltransferase activity
AS53_RS24785	COG0697	spore germination
AS53_RS24790	COG2318	DinB family
AS53_RS24810	COG4912	Dna alkylation repair
AS53_RS24830	COG0861	Integral membrane protein TerC family
AS53_RS24835	COG1368	sulfuric ester hydrolase activity
AS53_RS24840	COG0488	(ABC) transporter
AS53_RS24850	COG2409	Drug exporters of the RND superfamily
AS53_RS24850	COG1033	growth of symbiont in host cell
AS53_RS24855	COG1033	growth of symbiont in host cell
AS53_RS24855	COG2409	Drug exporters of the RND superfamily
AS53_RS24860	COG2409	Drug exporters of the RND superfamily
AS53_RS24860	COG1033	growth of symbiont in host cell
AS53_RS24865	COG1309	transcriptional regulator
AS53_RS24880	COG0287	Prephenate dehydrogenase
AS53_RS24885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS53_RS24890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AS53_RS24895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AS53_RS24895	COG1605	Chorismate mutase
AS53_RS24930	COG3584	3D domain protein
AS53_RS24930	COG1388	LysM domain
AS53_RS24940	COG1595	DNA-templated transcription, initiation
AS53_RS24965	COG1879	ABC-type sugar transport system periplasmic component
AS53_RS24975	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS53_RS24985	COG2390	Transcriptional regulator
AS53_RS25020	COG2329	Antibiotic biosynthesis monooxygenase
AS53_RS25040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS53_RS25050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AS53_RS25055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS53_RS25060	COG4187	Peptidase family M20/M25/M40
AS53_RS25065	COG1414	Transcriptional regulator
AS53_RS25070	COG0833	amino acid
AS53_RS25075	COG1690	Belongs to the RtcB family
AS53_RS25080	COG3239	Fatty acid desaturase
AS53_RS25085	COG1785	Belongs to the alkaline phosphatase family
AS53_RS25095	COG3655	Transcriptional regulator
AS53_RS25110	COG4377	Putative membrane peptidase family (DUF2324)
AS53_RS25120	COG3279	Response regulator of the LytR AlgR family
AS53_RS25130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS53_RS25135	COG0346	lactoylglutathione lyase activity
AS53_RS25155	COG0714	Associated with various cellular activities
AS53_RS25180	COG0463	Glycosyl transferase, family 2
AS53_RS25205	COG0463	Glycosyl transferase, family 2
AS53_RS25215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AS53_RS25220	COG0753	catalase activity
AS53_RS25230	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AS53_RS25255	COG0714	Associated with various cellular activities
AS53_RS25265	COG0778	Nitroreductase
AS53_RS25270	COG1846	Transcriptional regulator
AS53_RS25305	COG1725	Transcriptional regulator
AS53_RS25315	COG1136	(ABC) transporter
AS53_RS25315	COG0577	efflux transmembrane transporter activity
AS53_RS25340	COG2207	Transcriptional regulator
AS53_RS25345	COG0456	acetyltransferase
AS53_RS25365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS53_RS25385	COG0642	Histidine kinase
AS53_RS25390	COG0745	RESPONSE REGULATOR receiver
AS53_RS25395	COG0596	Alpha beta hydrolase
AS53_RS25425	COG0730	response to heat
AS53_RS25435	COG0833	amino acid
AS53_RS25445	COG4335	DNA alkylation repair
AS53_RS25485	COG0768	penicillin binding
AS53_RS25495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AS53_RS25530	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AS53_RS25535	COG1414	Transcriptional regulator
AS53_RS25550	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS53_RS25555	COG0640	Transcriptional regulator
AS53_RS25565	COG1960	acyl-CoA dehydrogenase activity
AS53_RS25585	COG3314	Sporulation integral membrane protein YlbJ
AS53_RS25600	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AS53_RS25615	COG3848	Pyruvate phosphate dikinase
AS53_RS25615	COG0574	Belongs to the PEP-utilizing enzyme family
AS53_RS25620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_RS25635	COG5577	PFAM Coat F domain
AS53_RS25640	COG3403	YqcI/YcgG family
AS53_RS25645	COG1280	lysine exporter protein (LysE YggA)
AS53_RS25680	COG1063	alcohol dehydrogenase
AS53_RS25695	COG1027	Aspartate ammonia-lyase
AS53_RS25700	COG0252	asparaginase activity
AS53_RS25705	COG1396	sequence-specific DNA binding
AS53_RS25715	COG0322	excinuclease ABC activity
AS53_RS25720	COG0531	amino acid
AS53_RS25725	COG1114	Component of the transport system for branched-chain amino acids
AS53_RS25730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS53_RS25740	COG0281	malic enzyme
AS53_RS25760	COG0531	amino acid
AS53_RS25765	COG0697	spore germination
AS53_RS25770	COG0784	Response regulator, receiver
AS53_RS25780	COG2066	Belongs to the glutaminase family
AS53_RS25785	COG1115	amino acid carrier protein
AS53_RS25810	COG0737	Belongs to the 5'-nucleotidase family
AS53_RS25815	COG0753	catalase activity
AS53_RS25820	COG2267	carboxylic ester hydrolase activity
AS53_RS25825	COG1335	isochorismatase
AS53_RS25850	COG0583	DNA-binding transcription factor activity
AS53_RS25895	COG0415	Belongs to the DNA photolyase family
AS53_RS25900	COG0288	reversible hydration of carbon dioxide
AS53_RS25910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS53_RS25915	COG5609	conserved protein (DUF2294)
AS53_RS25925	COG1575	Belongs to the MenA family. Type 1 subfamily
AS53_RS25930	COG2267	carboxylic ester hydrolase activity
AS53_RS25935	COG0803	Belongs to the bacterial solute-binding protein 9 family
AS53_RS25940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS53_RS25945	COG1121	(ABC) transporter
AS53_RS25975	COG0798	PFAM Bile acid sodium symporter
AS53_RS25980	COG0346	lactoylglutathione lyase activity
AS53_RS25985	COG0640	Transcriptional regulator
AS53_RS26000	COG0443	Heat shock 70 kDa protein
AS53_RS26015	COG1522	sequence-specific DNA binding
AS53_RS26030	COG0346	lactoylglutathione lyase activity
AS53_RS26055	COG2169	Transcriptional regulator
AS53_RS26100	COG2814	Major facilitator Superfamily
AS53_RS26125	COG0745	RESPONSE REGULATOR receiver
AS53_RS26130	COG5002	protein histidine kinase activity
AS53_RS26130	COG3850	Histidine kinase
AS53_RS26160	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AS53_RS26185	COG1476	TRANSCRIPTIONal
AS53_RS26200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_RS26205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS53_RS26215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS53_RS26220	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AS53_RS26235	COG1136	(ABC) transporter
AS53_RS26240	COG0577	efflux transmembrane transporter activity
AS53_RS26260	COG3850	Histidine kinase
AS53_RS26260	COG5002	protein histidine kinase activity
AS53_RS26270	COG2364	Membrane
AS53_RS26275	COG1846	Transcriptional regulator
AS53_RS26285	COG2808	Putative FMN-binding domain
AS53_RS26290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_RS26295	COG2271	Major facilitator Superfamily
AS53_RS26300	COG1556	Lactate utilization protein
AS53_RS26305	COG1139	Iron-sulfur cluster binding protein
AS53_RS26315	COG0583	DNA-binding transcription factor activity
AS53_RS26325	COG1619	proteins homologs of microcin C7 resistance protein MccF
AS53_RS26350	COG0738	Major facilitator superfamily
AS53_RS26355	COG0673	inositol 2-dehydrogenase activity
AS53_RS26360	COG0561	phosphatase activity
AS53_RS26370	COG1609	Transcriptional regulator
AS53_RS26375	COG0457	Tetratricopeptide repeat
AS53_RS26395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS53_RS26425	COG0534	Mate efflux family protein
AS53_RS26440	COG2814	Major facilitator Superfamily
AS53_RS26445	COG1309	transcriptional regulator
AS53_RS26460	COG0814	amino acid
AS53_RS26465	COG1760	l-serine dehydratase
AS53_RS26470	COG1760	l-serine dehydratase
AS53_RS26480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS53_RS26485	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AS53_RS26495	COG1335	isochorismatase
AS53_RS26500	COG1522	sequence-specific DNA binding
AS53_RS26505	COG0531	amino acid
AS53_RS26520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS53_RS26540	COG1595	DNA-templated transcription, initiation
AS53_RS26555	COG0662	Cupin 2, conserved barrel domain protein
AS53_RS26565	COG2207	Transcriptional regulator
AS53_RS26565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_RS26620	COG0477	Major facilitator Superfamily
AS53_RS26630	COG1846	Transcriptional regulator
AS53_RS26635	COG2814	Major facilitator Superfamily
AS53_RS26650	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS53_RS26655	COG1131	(ABC) transporter
AS53_RS26675	COG2076	Multidrug Resistance protein
AS53_RS26680	COG1309	transcriptional regulator
AS53_RS26695	COG2031	fatty acid transporter
AS53_RS26705	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS53_RS26735	COG1122	ATPase activity
AS53_RS26740	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AS53_RS26755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS53_RS26760	COG1288	antiporter activity
AS53_RS26765	COG2356	endonuclease I
AS53_RS26780	COG3620	sequence-specific DNA binding
AS53_RS26785	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AS53_RS26790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AS53_RS26795	COG0124	histidyl-tRNA synthetase
AS53_RS26810	COG1733	regulation of RNA biosynthetic process
AS53_RS26815	COG0778	Nitroreductase
AS53_RS26835	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS26845	COG1131	(ABC) transporter
AS53_RS26870	COG1011	Hydrolase
AS53_RS26880	COG2365	Tyrosine phosphatase family
AS53_RS26905	COG0346	lactoylglutathione lyase activity
AS53_RS26910	COG1940	carbohydrate kinase activity
AS53_RS26915	COG0738	Major facilitator superfamily
AS53_RS26920	COG0110	maltose O-acetyltransferase activity
AS53_RS26930	COG0577	efflux transmembrane transporter activity
AS53_RS26930	COG1136	(ABC) transporter
AS53_RS26940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AS53_RS26945	COG0628	permease
AS53_RS26965	COG2226	methyltransferase
AS53_RS26975	COG0477	Major facilitator Superfamily
AS53_RS27005	COG1253	flavin adenine dinucleotide binding
AS53_RS27010	COG0789	Transcriptional regulator
AS53_RS27015	COG0697	spore germination
AS53_RS27020	COG1357	PFAM Pentapeptide repeats (8 copies)
AS53_RS27025	COG3813	Protein conserved in bacteria
AS53_RS27030	COG2706	6-phosphogluconolactonase activity
AS53_RS27035	COG1070	Carbohydrate kinase
AS53_RS27045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS53_RS27050	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AS53_RS27060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS53_RS27065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS53_RS27070	COG0604	alcohol dehydrogenase
AS53_RS27075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS53_RS27085	COG3321	synthase
AS53_RS27085	COG0604	alcohol dehydrogenase
AS53_RS27095	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS27120	COG0656	L-ascorbic acid biosynthetic process
AS53_RS27125	COG2814	Major facilitator Superfamily
AS53_RS27140	COG0346	lactoylglutathione lyase activity
AS53_RS27145	COG0814	amino acid
AS53_RS27170	COG1393	Belongs to the ArsC family
AS53_RS27180	COG1733	regulation of RNA biosynthetic process
AS53_RS27185	COG2188	Transcriptional regulator
AS53_RS27195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AS53_RS27200	COG1733	regulation of RNA biosynthetic process
AS53_RS27205	COG1733	regulation of RNA biosynthetic process
AS53_RS27220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_RS27240	COG0384	phenazine biosynthesis protein PhzF
AS53_RS27250	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS27260	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_RS27270	COG1733	regulation of RNA biosynthetic process
AS53_RS27305	COG1191	sigma factor activity
AS53_RS27320	COG1309	transcriptional regulator
AS53_RS27340	COG3152	Membrane
AS53_RS27365	COG1151	hydroxylamine reductase activity
AS53_RS27375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS53_RS27380	COG3757	hydrolase, family 25
AS53_RS27380	COG3409	Peptidoglycan-binding domain 1 protein
AS53_RS27415	COG2072	flavoprotein involved in K transport
AS53_RS27450	COG0604	alcohol dehydrogenase
AS53_RS27455	COG1113	amino acid transport
AS53_RS27460	COG2814	Major facilitator Superfamily
AS53_RS27495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS53_RS27500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS53_RS27520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS53_RS27530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_RS27535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS53_RS27540	COG3739	integral membrane protein
AS53_RS27545	COG0384	phenazine biosynthesis protein PhzF
AS53_RS27575	COG0583	DNA-binding transcription factor activity
AS53_RS27595	COG1193	negative regulation of DNA recombination
AS53_RS27610	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AS53_RS27620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS53_RS27650	COG0584	glycerophosphoryl diester phosphodiesterase
AS53_RS27675	COG0640	Transcriptional regulator
AS53_RS27680	COG0604	alcohol dehydrogenase
AS53_RS27700	COG2808	Putative FMN-binding domain
AS53_RS27705	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS53_RS27715	COG0385	Bile acid
AS53_RS27720	COG0277	FAD linked oxidase domain protein
AS53_RS27765	COG1024	Enoyl-CoA hydratase
AS53_RS27775	COG1285	pathogenesis
AS53_RS27785	COG2514	catechol 2,3-dioxygenase activity
AS53_RS27790	COG2720	vancomycin resistance protein
AS53_RS27830	COG0716	FMN binding
AS53_RS27860	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS27870	COG0165	Argininosuccinate lyase
AS53_RS27885	COG4145	pantothenate transmembrane transporter activity
AS53_RS27895	COG1012	belongs to the aldehyde dehydrogenase family
AS53_RS27900	COG1028	Short-chain dehydrogenase reductase Sdr
AS53_RS27910	COG1657	PFAM Prenyltransferase squalene oxidase
AS53_RS27915	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AS53_RS27920	COG2962	Rard protein
AS53_RS27925	COG3326	Membrane
AS53_RS27940	COG0489	protein tyrosine kinase activity
AS53_RS27950	COG0314	molybdopterin synthase activity
AS53_RS27955	COG0303	'Molybdopterin
AS53_RS27960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS53_RS27965	COG2116	formate transmembrane transporter activity
AS53_RS27975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS53_RS27980	COG5609	conserved protein (DUF2294)
AS53_RS27985	COG2427	Protein of unknown function (DUF1641)
AS53_RS28000	COG0697	spore germination
AS53_RS28040	COG2226	methyltransferase
AS53_RS28045	COG4166	transmembrane transport
AS53_RS28050	COG4166	transmembrane transport
AS53_RS28055	COG4166	transmembrane transport
AS53_RS28060	COG1301	dicarboxylic acid transport
AS53_RS28065	COG1316	TRANSCRIPTIONal
AS53_RS28075	COG1595	DNA-templated transcription, initiation
AS53_RS28100	COG1131	(ABC) transporter
AS53_RS28110	COG0673	inositol 2-dehydrogenase activity
AS53_RS28115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AS53_RS28120	COG0187	DNA topoisomerase II activity
AS53_RS28130	COG1832	CoA-binding protein
AS53_RS28135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS53_RS28140	COG0745	RESPONSE REGULATOR receiver
AS53_RS28155	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AS53_RS28160	COG4841	protein insertion into membrane
AS53_RS28165	COG0824	Thioesterase
AS53_RS28195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS53_RS28205	COG2274	protein secretion by the type I secretion system
AS53_RS28210	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AS53_RS28240	COG2211	Major facilitator Superfamily
AS53_RS28250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AS53_RS28265	COG0183	Belongs to the thiolase family
AS53_RS28270	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_RS28275	COG1268	BioY protein
AS53_RS28280	COG0318	PFAM AMP-dependent synthetase and ligase
AS53_RS28325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS53_RS28335	COG5002	protein histidine kinase activity
AS53_RS28340	COG0400	carboxylic ester hydrolase activity
AS53_RS28345	COG0346	lactoylglutathione lyase activity
AS53_RS28350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS53_RS28355	COG0069	glutamate synthase activity
AS53_RS28360	COG1902	pentaerythritol trinitrate reductase activity
AS53_RS28365	COG1329	Transcriptional regulator
AS53_RS28370	COG0010	Belongs to the arginase family
AS53_RS28395	COG2226	methyltransferase
AS53_RS28600	COG3639	organic phosphonate transmembrane transporter activity
AS53_RS28950	COG1113	amino acid transport
AS53_RS29310	COG2376	Dihydroxyacetone kinase