locus-tag class description AS53_RS00070 ENOG4105K4H Nlp p60 protein AS53_RS00215 ENOG4107QJE Chromosome Partitioning Protein AS53_RS00260 ENOG4105EWC Purine nucleoside phosphorylase AS53_RS00335 ENOG4105C3F Signal peptidase i AS53_RS00360 ENOG4105N14 lysine exporter protein LysE YggA AS53_RS00395 ENOG4108J59 Extracellular solute-binding protein, family 5 AS53_RS00410 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AS53_RS00485 ENOG4107QIV Cytochrome c biogenesis protein AS53_RS00495 ENOG4107RSM transcriptional regulator AS53_RS00500 ENOG4105VAW lrga family AS53_RS00505 ENOG41067MG lrgb family AS53_RS00530 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS53_RS00545 ENOG4105BZ1 (ABC) transporter AS53_RS00550 ENOG4105BZ1 (ABC) transporter AS53_RS00570 ENOG4105D7V transposase AS53_RS00590 ENOG4105D5T phosphonate abc transporter AS53_RS00615 ENOG4108SVB resolvase AS53_RS00635 ENOG4105K7K Transcriptional regulator AS53_RS00670 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AS53_RS00675 ENOG4105XSJ toxin secretion phage lysis holin AS53_RS00880 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AS53_RS00985 ENOG4105C5F glutamine synthetase AS53_RS00990 ENOG4105KV4 Transcriptional regulator AS53_RS00995 ENOG4105CXI aluminum resistance protein AS53_RS01005 ENOG4105EN6 Membrane AS53_RS01010 ENOG4106F1P AAA ATPase, central domain protein AS53_RS01040 ENOG41069ER domain protein AS53_RS01045 ENOG4105DM4 PTS System AS53_RS01050 ENOG4105DE4 1-phosphofructokinase AS53_RS01055 ENOG4105E98 transcriptional regulator DeoR family AS53_RS01065 ENOG4108SJC Membrane AS53_RS01080 ENOG4105C85 amino acid AS53_RS01095 ENOG4105TMB Formate nitrite transporter AS53_RS01100 ENOG4105K70 DNA-binding protein AS53_RS01105 ENOG4105C59 p-type ATPase AS53_RS01110 ENOG410681U heavy metal transport detoxification protein AS53_RS01115 ENOG4105VPX protein, conserved in bacteria AS53_RS01125 ENOG4105NIV Esterase AS53_RS01130 ENOG4105E0A ABC, transporter AS53_RS01155 ENOG4105CGK Exodeoxyribonuclease III AS53_RS01165 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AS53_RS01170 ENOG4105D03 DNA-3-methyladenine glycosylase II AS53_RS01200 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_RS01205 ENOG4105BZU Histidine kinase AS53_RS01225 ENOG41067MG lrgb family AS53_RS01240 ENOG4107TTQ Alpha beta hydrolase fold AS53_RS01245 ENOG4107YEI lmbE family AS53_RS01265 ENOG4105F0V Cell wall hydrolase AS53_RS01270 ENOG4107R6R udp-galactopyranose mutase AS53_RS01275 ENOG4105E0M Sulfatase AS53_RS01290 ENOG4107QHE Choloylglycine hydrolase AS53_RS01315 ENOG4105DA5 (ABC) transporter AS53_RS01340 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AS53_RS01345 ENOG4105DQU oxidoreductase, subunit beta AS53_RS01350 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AS53_RS01355 ENOG4108IGT Dipeptidase AS53_RS01360 ENOG4105MCT stage V sporulation protein S AS53_RS01365 ENOG4105D48 metallophosphoesterase AS53_RS01390 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AS53_RS01405 ENOG4105XZV Protein of unknown function (DUF3243) AS53_RS01410 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AS53_RS01440 ENOG4108JQ9 ABC transporter AS53_RS01445 ENOG4105DIH basic membrane AS53_RS01450 ENOG4105FDP GntR family transcriptional regulator AS53_RS01455 ENOG4107QZI cell division protein FtsK AS53_RS01465 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AS53_RS01480 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AS53_RS01490 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AS53_RS01495 ENOG4108S0H Dipicolinic acid synthetase, b subunit AS53_RS01500 ENOG4105E35 Dipicolinate synthase subunit A AS53_RS01510 ENOG4105C1V Peptidase, M16 AS53_RS01530 ENOG4105DTN riboflavin biosynthesis protein ribF AS53_RS01535 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AS53_RS01545 ENOG4105W7A Protein of unknown function (DUF503) AS53_RS01555 ENOG4105VHM ribosomal protein AS53_RS01560 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AS53_RS01565 ENOG4105CHV Transcription elongation factor NusA AS53_RS01575 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AS53_RS01585 ENOG4105DZP Membrane-associated zinc metalloprotease AS53_RS01595 ENOG4105KNE Phosphatidate cytidylyltransferase AS53_RS01600 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AS53_RS01640 ENOG4108HE4 integrase family AS53_RS01650 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AS53_RS01660 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AS53_RS01675 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AS53_RS01700 ENOG4105VB6 UPF0109 protein AS53_RS01720 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AS53_RS01725 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AS53_RS01740 ENOG4105CHR reductase AS53_RS01745 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AS53_RS01760 ENOG4105CB5 ATP-dependent DNA helicase recG AS53_RS01765 ENOG4105DP4 dak2 domain fusion protein ylov AS53_RS01770 ENOG4108ZAA Alkaline-shock protein AS53_RS01785 ENOG4105FJ0 thiamine AS53_RS01790 ENOG4105DJV ribulose-phosphate 3-epimerase AS53_RS01795 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AS53_RS01800 ENOG4105D9P serine threonine protein kinase AS53_RS01805 ENOG4108ZF3 Phosphatase AS53_RS01815 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AS53_RS01825 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AS53_RS01830 ENOG4105C25 Primosomal protein n' AS53_RS01835 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AS53_RS01855 ENOG4105DSJ YicC domain protein AS53_RS01870 ENOG4105DC7 peptidase M24 AS53_RS01950 ENOG4105C34 Pseudouridine synthase AS53_RS01975 ENOG4105DBK s4 domain protein AS53_RS01980 ENOG41067XK integral membrane protein AS53_RS01990 ENOG4105DFA alanine racemase domain protein AS53_RS01995 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AS53_RS02000 ENOG4105WR5 sporulation protein, YlmC YmxH family AS53_RS02010 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_RS02020 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AS53_RS02025 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AS53_RS02030 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AS53_RS02035 ENOG4105D4A Cell wall formation (By similarity) AS53_RS02045 ENOG4105CNI cell division protein FtsW AS53_RS02060 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AS53_RS02065 ENOG4105CJN penicillin-binding protein AS53_RS02070 ENOG4105CJN penicillin-binding protein AS53_RS02075 ENOG41068DC Essential cell division protein (By similarity) AS53_RS02110 ENOG4105KNH Nucleic acid-binding protein AS53_RS02160 ENOG4105XSJ toxin secretion phage lysis holin AS53_RS02255 ENOG4105CAR Terminase, large subunit AS53_RS02360 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_RS02415 ENOG4108IMY Transcriptional regulator AS53_RS02440 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AS53_RS02450 ENOG41063PX domain protein AS53_RS02455 ENOG4105D78 K07001 NTE family protein AS53_RS02460 ENOG4105H20 Sporulation integral membrane protein YlbJ AS53_RS02470 ENOG4106H78 methyltransferase AS53_RS02490 ENOG4107TB6 phosphoglycerate mutase AS53_RS02505 ENOG4106UY4 Inherit from COG: Scp-like extracellular AS53_RS02555 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AS53_RS02560 ENOG4105CNI cell division protein FtsW AS53_RS02575 ENOG4108IAB Phoh family AS53_RS02595 ENOG4105QA2 AS53_RS02600 ENOG4105CI3 gtp-binding protein typa AS53_RS02610 ENOG4105ECY inositol monophosphatase AS53_RS02630 ENOG4105CXN decarboxylase AS53_RS02675 ENOG4105C7S Dehydrogenase AS53_RS02680 ENOG4105CPP Dehydrogenase, E1 component AS53_RS02695 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AS53_RS02700 ENOG4108X4Q Hydrolase AS53_RS02710 ENOG4105CN5 Metallo-Beta-Lactamase AS53_RS02715 ENOG4107ZYR domain protein AS53_RS02750 ENOG4108XRC Protein of unknown function (DUF458) AS53_RS02760 ENOG4107IN1 Protein of unknown function (DUF1797) AS53_RS02775 ENOG4105EPM Diguanylate phosphodiesterase AS53_RS02780 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AS53_RS02795 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AS53_RS02805 ENOG4105UIN AS53_RS02870 ENOG4108HGU Histidine kinase AS53_RS02880 ENOG4105CHM Aminotransferase AS53_RS02885 ENOG4105FKQ transcriptional regulator AS53_RS02890 ENOG4105EG2 ABC transporter, permease AS53_RS02900 ENOG4107FKK extracellular solute-binding protein family 1 AS53_RS02910 ENOG4105CG3 alpha amylase, catalytic region AS53_RS02955 ENOG4105CHU acetyl-coa acetyltransferase AS53_RS02995 ENOG4105K7K Transcriptional regulator AS53_RS03000 ENOG4105DTD Dehydrogenase AS53_RS03020 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AS53_RS03045 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AS53_RS03065 ENOG4106TD9 Diguanylate cyclase AS53_RS03085 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AS53_RS03100 ENOG4105CID antiterminator AS53_RS03120 ENOG4105CE4 GlcNAc 6-P deacetylase AS53_RS03165 ENOG4107ZE5 PPIases accelerate the folding of proteins AS53_RS03170 ENOG4105PTM secreted protein AS53_RS03175 ENOG4105J7I hydrolase AS53_RS03185 ENOG4105G6R Stage v sporulation protein ae AS53_RS03195 ENOG4105CZ3 stage V sporulation protein ad AS53_RS03200 ENOG41090VF Stage v sporulation protein ac AS53_RS03220 ENOG4105C8J )-transporter AS53_RS03225 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_RS03235 ENOG41082AN stage II sporulation protein AS53_RS03240 ENOG4105DZ1 carboxypeptidase AS53_RS03245 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AS53_RS03250 ENOG4105DVE abc transporter atp-binding protein AS53_RS03285 ENOG4105D7N magnesium and cobalt transport protein CorA AS53_RS03310 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AS53_RS03320 ENOG4105I3K Ferric uptake regulator, Fur family AS53_RS03325 ENOG4105MZ9 stage II sporulation protein m AS53_RS03345 ENOG4105CPC Aldo Keto reductase AS53_RS03355 ENOG4105RHY Pfam:UPF0157 AS53_RS03375 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AS53_RS03390 ENOG4108YM7 Gcn5-related n-acetyltransferase AS53_RS03410 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AS53_RS03415 ENOG4108R6K riboflavin synthase, subunit alpha AS53_RS03440 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS53_RS03445 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS53_RS03460 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS53_RS03470 ENOG4105DFD Na H antiporter AS53_RS03475 ENOG4105CGH 5'-nucleotidase AS53_RS03515 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AS53_RS03530 ENOG4108IXY short-chain dehydrogenase reductase AS53_RS03545 ENOG4105II7 pyrroline-5-carboxylate reductase AS53_RS03550 ENOG4105EJQ L-serine dehydratase AS53_RS03575 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AS53_RS03585 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AS53_RS03590 ENOG4105D9U N-acetyltransferase AS53_RS03605 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AS53_RS03610 ENOG4108QEG Membrane AS53_RS03615 ENOG4105CDA abc transporter atp-binding protein AS53_RS03620 ENOG4105E5Q amino acid AbC transporter AS53_RS03625 ENOG4108HW3 (ABC) transporter AS53_RS03635 ENOG4105G7B Protein of unknown function (DUF2992) AS53_RS03655 ENOG4105C7S Dehydrogenase AS53_RS03660 ENOG4105CPP Dehydrogenase, E1 component AS53_RS03680 ENOG4107RDP Dehydrogenase AS53_RS03695 ENOG4108JUB Transcriptional regulator AS53_RS03705 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AS53_RS03720 ENOG4107QQR Sporulation AS53_RS03730 ENOG4105S1Z Stage IV sporulation protein B AS53_RS03735 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AS53_RS03745 ENOG4105DX0 Hemolysin A AS53_RS03755 ENOG4105CTB Polyprenyl synthetase AS53_RS03780 ENOG4108ZSR alkaline shock protein AS53_RS03785 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AS53_RS03810 ENOG410644B Stage III sporulation protein af AS53_RS03820 ENOG4105KQ4 Stage iii sporulation protein ad AS53_RS03825 ENOG4108CQH stage III sporulation protein AC AS53_RS03830 ENOG4105KR5 Stage iii sporulation protein AS53_RS03835 ENOG4105CD2 stage iii sporulation protein aa AS53_RS03860 ENOG4105DC7 peptidase M24 AS53_RS03875 ENOG4105CBJ Metal-dependent enzyme AS53_RS03885 ENOG4107YBY Hydrolase AS53_RS03905 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AS53_RS03910 ENOG4105WZW rhodanese family AS53_RS03930 ENOG41080TC multidrug resistance protein AS53_RS03970 ENOG4105CJ1 ABC, transporter AS53_RS03975 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AS53_RS04005 ENOG4105C0D helicase AS53_RS04125 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AS53_RS04130 ENOG4105C3R Methionine synthase AS53_RS04145 ENOG4105C28 cystathionine AS53_RS04150 ENOG4105C28 cystathionine AS53_RS04175 ENOG4105C5X domain protein AS53_RS04185 ENOG4105DKQ ROK family AS53_RS04195 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AS53_RS04210 ENOG4108UTW Plays a role in the regulation of phosphate uptake AS53_RS04220 ENOG4105E2Z phosphate ABC transporter (Permease AS53_RS04225 ENOG4105C8U phosphate abc transporter AS53_RS04230 ENOG4105PWN phosphate abc transporter AS53_RS04235 ENOG4107RF6 penicillin-binding protein AS53_RS04245 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS53_RS04270 ENOG4105N80 Ferric uptake regulator, Fur family AS53_RS04280 ENOG4105FDK ABC transporter AS53_RS04285 ENOG4108JYZ YitT family AS53_RS04290 ENOG41069ZM Protein of unknown function (DUF2624) AS53_RS04315 ENOG4105EGD dinuclear metal center protein, YbgI family AS53_RS04330 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_RS04335 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AS53_RS04370 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AS53_RS04375 ENOG4105KG3 cytidine deaminase AS53_RS04380 ENOG4107YR5 Diacylglycerol kinase AS53_RS04390 ENOG4105CTJ Metal Dependent Phosphohydrolase AS53_RS04395 ENOG4105C9A Phoh family AS53_RS04410 ENOG41068P3 sporulation protein YqfC AS53_RS04415 ENOG4105KTH gatB Yqey AS53_RS04425 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AS53_RS04430 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AS53_RS04460 ENOG4105CSA Coproporphyrinogen iii oxidase AS53_RS04465 ENOG4105KVH Transcriptional regulator AS53_RS04490 ENOG4105TQK DNA polymerase iii, delta' subunit AS53_RS04500 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AS53_RS04505 ENOG4108UK2 deaminase AS53_RS04510 ENOG4105KQC Competence protein AS53_RS04520 ENOG4105DXX methyltransferase AS53_RS04530 ENOG4108WF2 Metal Dependent Phosphohydrolase AS53_RS04540 ENOG410812S Rna-binding protein AS53_RS04550 ENOG4105CQW ribosome biogenesis GTPase YqeH AS53_RS04555 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AS53_RS04570 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_RS04590 ENOG4108TVJ Nitroreductase AS53_RS04605 ENOG4105G6Z alkaline phosphatase AS53_RS04615 ENOG4108MUZ hydrolase AS53_RS04650 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AS53_RS04655 ENOG4105MIR Phenylalanine 4-monooxygenase AS53_RS04710 ENOG4105S6R Iron-hydroxamate transporter permease subunit AS53_RS04715 ENOG4108V5C ABC transporter AS53_RS04725 ENOG4105C0A alcohol dehydrogenase AS53_RS04730 ENOG4105C28 cystathionine AS53_RS04760 ENOG4107XRG penicillin-binding protein AS53_RS04775 ENOG4105CFP Peptidase U32 AS53_RS04780 ENOG4105XYU peptidase (U32 family) AS53_RS04790 ENOG4105HHA aminodeoxychorismate lyase AS53_RS04810 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AS53_RS04820 ENOG4105C02 permease AS53_RS04835 ENOG41060CR AS53_RS04840 ENOG4105C7H Helicase, RecD TraA family AS53_RS04850 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AS53_RS04855 ENOG4105C3J Cysteine desulfurase AS53_RS04865 ENOG4105D1H recombination factor protein RarA AS53_RS04870 ENOG4108VCI transcription factor, rsfa family AS53_RS04875 ENOG4105CUZ uba thif-type nad fad binding protein AS53_RS04900 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AS53_RS04910 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AS53_RS04915 ENOG41076HS cation diffusion facilitator family transporter AS53_RS04920 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AS53_RS04930 ENOG4105CKP Polysaccharide Biosynthesis Protein AS53_RS04935 ENOG4108QG2 Membrane AS53_RS04945 ENOG4105VIE preprotein translocase, subunit YajC AS53_RS04960 ENOG41061AI Protein of unknown function (DUF2905) AS53_RS04975 ENOG4108HUF Transporter AS53_RS04985 ENOG4108IPJ Membrane AS53_RS04990 ENOG4108IPJ Membrane AS53_RS04995 ENOG41082BM Transcriptional regulator, arsr family AS53_RS05020 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AS53_RS05025 ENOG4108IYU L-aspartate oxidase AS53_RS05040 ENOG4108RPX mosc domain containing protein AS53_RS05045 ENOG4105CQC Prephenate dehydratase AS53_RS05080 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AS53_RS05095 ENOG4105X36 (ribosomal) protein AS53_RS05105 ENOG4105C03 ribonuclease AS53_RS05120 ENOG4107QMS site-determining protein AS53_RS05140 ENOG4105DFF Rod shape-determining protein mreb AS53_RS05160 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AS53_RS05165 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AS53_RS05175 ENOG41068KH stage VI sporulation protein D AS53_RS05185 ENOG4105D52 delta-aminolevulinic acid dehydratase AS53_RS05210 ENOG4105K56 Transcriptional regulator AS53_RS05230 ENOG4108IUQ atp-dependent protease AS53_RS05260 ENOG4108QCI YvbH-like oligomerisation region AS53_RS05280 ENOG4105M59 Phosphodiesterase, mj0936 family AS53_RS05295 ENOG4108XJQ germination protein AS53_RS05305 ENOG4108PCX Major Facilitator AS53_RS05315 ENOG4105KBX Transcriptional regulator, TetR family AS53_RS05330 ENOG4105PFC Transcriptional regulator AS53_RS05345 ENOG4105DZC cytosine deaminase AS53_RS05350 ENOG4105DZC cytosine deaminase AS53_RS05355 ENOG4105DEF Extracellular solute-binding protein, family 5 AS53_RS05360 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS53_RS05375 ENOG4108JQ7 (ABC) transporter AS53_RS05385 ENOG4105DY9 regulatoR AS53_RS05400 ENOG41067S9 phage shock protein C, PspC AS53_RS05405 ENOG4108JCI Transcriptional regulator AS53_RS05415 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AS53_RS05420 ENOG4108Z40 Transcriptional regulator AS53_RS05425 ENOG4105RHA ABC transporter, permease AS53_RS05430 ENOG4108IUX (ABC) transporter AS53_RS05435 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AS53_RS05445 ENOG4105E14 MotA TolQ exbB proton channel AS53_RS05450 ENOG4108VXD carboxy-peptidase AS53_RS05460 ENOG4105E33 succinate dehydrogenase AS53_RS05470 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AS53_RS05485 ENOG4105K63 Thioredoxin AS53_RS05490 ENOG4105C10 Electron transfer flavoprotein AS53_RS05495 ENOG4105BZJ Electron transfer flavoprotein AS53_RS05500 ENOG41060WC Enoyl-CoA hydratase AS53_RS05505 ENOG4107Z3H Transcriptional regulator, TetR family AS53_RS05510 ENOG4105CEY Amp-dependent synthetase and ligase AS53_RS05520 ENOG4105J76 Periplasmic binding protein AS53_RS05525 ENOG4105S6R Iron-hydroxamate transporter permease subunit AS53_RS05570 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_RS05585 ENOG4105DR4 Methyltransferase AS53_RS05600 ENOG4105KFN sortase, SrtB family AS53_RS05605 ENOG4105E0A ABC, transporter AS53_RS05620 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AS53_RS05630 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AS53_RS05640 ENOG4105FE9 pseudouridine synthase AS53_RS05655 ENOG4105DCG PHP domain protein AS53_RS05705 ENOG4108RWN rrna methyltransferase AS53_RS05740 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_RS05745 ENOG4105CW7 secretion protein, HlyD family AS53_RS05750 ENOG4108JGH Tetr family transcriptional regulator AS53_RS05755 ENOG4105CN9 Peptidase m42 family protein AS53_RS05780 ENOG4105C22 threonyL-tRNA synthetase AS53_RS05785 ENOG4108TDW sporulation protein YtxC AS53_RS05810 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AS53_RS05815 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AS53_RS05830 ENOG4105C2M dna polymerase I AS53_RS05835 ENOG4105BZU Histidine kinase AS53_RS05840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_RS05860 ENOG4108HMX isocitrate dehydrogenase (NADP) AS53_RS05865 ENOG4105BZN citrate synthase AS53_RS05880 ENOG4108REF Sporulation integral membrane protein ytvi AS53_RS05885 ENOG4105FS0 cytoplasmic membrane protein AS53_RS05910 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AS53_RS05915 ENOG4105C6K Malic enzyme AS53_RS05920 ENOG4105C0B DNA polymerase III (alpha subunit) AS53_RS05925 ENOG4105VV2 AS53_RS05935 ENOG4105SFS phosphoesterase RecJ domain protein AS53_RS05970 ENOG4105DC7 peptidase M24 AS53_RS06005 ENOG4105Z7P Acetyltransferase (GNAT) family AS53_RS06010 ENOG41082W1 Cupin 2, conserved barrel domain protein AS53_RS06020 ENOG4105VZ8 Transcriptional regulator AS53_RS06040 ENOG4107YZX Universal stress protein AS53_RS06080 ENOG4108JYZ YitT family AS53_RS06100 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AS53_RS06110 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AS53_RS06115 ENOG4105KBJ sporulation protein ytfj AS53_RS06130 ENOG4105EFZ amidohydrolase AS53_RS06140 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AS53_RS06165 ENOG4106KR7 LysR family Transcriptional regulator AS53_RS06185 ENOG4105C28 cystathionine AS53_RS06215 ENOG4105EMN RNA polymerase sigma factor AS53_RS06230 ENOG4105F1V Acetoin utilization protein AS53_RS06235 ENOG4105W87 Cbs domain AS53_RS06240 ENOG4105DGU Histone deacetylase AS53_RS06250 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_RS06260 ENOG4107SNB ankyrin repeat protein YahD AS53_RS06265 ENOG4105EP9 oxidoreductase AS53_RS06295 ENOG4105ETE Transcriptional regulator (LacI family AS53_RS06320 ENOG4105C88 aminopeptidase AS53_RS06365 ENOG4108VDD TRNA binding domain protein AS53_RS06395 ENOG4105C8F Beta-lactamase domain protein AS53_RS06410 ENOG4108V15 phosphotransferase enzyme family AS53_RS06415 ENOG4108IUM Glycogen debranching enzyme AS53_RS06440 ENOG4105YW5 deoR family transcriptional regulator AS53_RS06455 ENOG4105CBX hi0933 family AS53_RS06490 ENOG4108VJ1 Transcriptional regulator (CarD family AS53_RS06495 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AS53_RS06500 ENOG4105CSC Glucose uptake protein AS53_RS06515 ENOG4108ZAF Molybdopterin AS53_RS06520 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AS53_RS06525 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS53_RS06535 ENOG4105D06 uba thif-type nad fad binding protein AS53_RS06560 ENOG41085GJ domain protein AS53_RS06570 ENOG4105DWV Homoserine O-trans-acetylase AS53_RS06580 ENOG4108B31 Spore germination protein AS53_RS06615 ENOG410605W Major Facilitator AS53_RS06620 ENOG4107S91 Sodium hydrogen exchanger AS53_RS06625 ENOG4105NCW Trka-c domain protein AS53_RS06640 ENOG4105C19 ABC transporter AS53_RS06660 ENOG4105N5T Radical SAM Protein AS53_RS06670 ENOG4105DA5 (ABC) transporter AS53_RS06700 ENOG4105E8V Alpha Beta Hydrolase Fold protein AS53_RS06705 ENOG4108Z0R Transferase AS53_RS06710 ENOG4105YVM Phosphoesterase, PA-phosphatase related AS53_RS06715 ENOG4105BZF Glycosyl transferase (Group 1 AS53_RS06725 ENOG4108RIR Molybdenum cofactor biosynthesis protein AS53_RS06780 ENOG4105EGD dinuclear metal center protein, YbgI family AS53_RS06785 ENOG4105BZU Histidine kinase AS53_RS06790 ENOG4105BZU Histidine kinase AS53_RS06795 ENOG4107S9D Alpha beta hydrolase AS53_RS06815 ENOG4105D2X ABC transporter substrate-binding protein AS53_RS06825 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AS53_RS06880 ENOG4108V2W Carbonate dehydratase AS53_RS06885 ENOG4105C4M (Ubiquinol oxidase) subunit I AS53_RS06890 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AS53_RS06935 ENOG41087YS Phage shock protein A AS53_RS06970 ENOG4105BZU Histidine kinase AS53_RS06975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS07000 ENOG4108UGV hypoxanthine phosphoribosyltransferase AS53_RS07005 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AS53_RS07040 ENOG4107ZTW SNARE associated Golgi AS53_RS07055 ENOG4105C19 ABC transporter AS53_RS07060 ENOG41086D8 Transcriptional regulator AS53_RS07110 ENOG4105C6Z Gluconate AS53_RS07135 ENOG41069H0 dihydroorotase EC 3.5.2.3 AS53_RS07165 ENOG4105DTQ mandelate racemase muconate lactonizing AS53_RS07175 ENOG4108IPT Naphthoate synthase AS53_RS07180 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AS53_RS07185 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AS53_RS07190 ENOG4105E4F Isochorismate synthase AS53_RS07195 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AS53_RS07205 ENOG4105VEQ Cold shock protein AS53_RS07230 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AS53_RS07345 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AS53_RS07425 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AS53_RS07460 ENOG4105KT7 mgtC SapB transporter AS53_RS07465 ENOG4107PBV potassium channel AS53_RS07475 ENOG4107QYV phosphohexose isomerase AS53_RS07485 ENOG4105WG9 Conserved Protein AS53_RS07495 ENOG4105CHM Aminotransferase AS53_RS07500 ENOG4108ZB6 transcriptional regulator AsnC family AS53_RS07505 ENOG4105C5I Dehydrogenase AS53_RS07510 ENOG4108MUZ hydrolase AS53_RS07520 ENOG4105C87 Aminotransferase class I and II AS53_RS07535 ENOG4105Y38 Kinase-associated protein B AS53_RS07545 ENOG4107R3E Citrate transporter AS53_RS07565 ENOG4105KA0 thioesterase Superfamily protein AS53_RS07585 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AS53_RS07605 ENOG41069ER domain protein AS53_RS07620 ENOG4105CEP NADH dehydrogenase AS53_RS07650 ENOG4105EWC Purine nucleoside phosphorylase AS53_RS07670 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AS53_RS07695 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AS53_RS07700 ENOG4105C4B ABC transporter, permease AS53_RS07705 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AS53_RS07750 ENOG41083MR nifu domain-containing protein AS53_RS07765 ENOG4108W5N phosphatidylglycerophosphatase a AS53_RS07780 ENOG4105DYS nad(p)h dehydrogenase (quinone) AS53_RS07785 ENOG4105D4U had-superfamily hydrolase, subfamily iia AS53_RS07800 ENOG4105CBT Fructose-1,6-bisphosphatase AS53_RS07820 ENOG4105MMD transcriptional regulator AS53_RS07825 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AS53_RS07830 ENOG4107TXC Transcriptional regulator AS53_RS07835 ENOG41090T1 Membrane AS53_RS07860 ENOG4105FAA peptidase M23 AS53_RS07870 ENOG4105KZD Domain of unknown function (DUF1805) AS53_RS07875 ENOG4107R8B 5'-nucleotidase AS53_RS07900 ENOG4105DIW FeS assembly protein SUFB AS53_RS07905 ENOG4108UNV SUF system FeS assembly protein, NifU family AS53_RS07910 ENOG4105C9B Cysteine desulfurase AS53_RS07915 ENOG4105JRK feS assembly protein SufD AS53_RS07920 ENOG4105C3K feS assembly ATPase SufC AS53_RS07930 ENOG4105D01 (LipO)protein AS53_RS07935 ENOG4108UMI ABC transporter, permease AS53_RS07970 ENOG41080E8 Transcriptional regulator, Spx MgsR family AS53_RS08020 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AS53_RS08045 ENOG4108W8B Beta-lactamase domain protein AS53_RS08050 ENOG4105C1G acyl-Coa dehydrogenase AS53_RS08060 ENOG4105CHU acetyl-coa acetyltransferase AS53_RS08075 ENOG4105DZ1 carboxypeptidase AS53_RS08095 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AS53_RS08115 ENOG4108SUT Major Facilitator Superfamily AS53_RS08120 ENOG4107R7I amino acid AS53_RS08130 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AS53_RS08140 ENOG4107AYK membrAne AS53_RS08175 ENOG4107ZTW SNARE associated Golgi AS53_RS08185 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AS53_RS08190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS08195 ENOG4105BZU Histidine kinase AS53_RS08220 ENOG4105VG1 fes assembly suf system protein AS53_RS08225 ENOG4105D4Y metalloprotease AS53_RS08245 ENOG4107S91 Sodium hydrogen exchanger AS53_RS08250 ENOG4105NCW Trka-c domain protein AS53_RS08265 ENOG4108RMU ferritin dps family protein AS53_RS08280 ENOG4108URH decarboxylase AS53_RS08305 ENOG4105D9N nucleoside AS53_RS08310 ENOG4105D9N nucleoside AS53_RS08325 ENOG4108RYK Nad-dependent epimerase dehydratase AS53_RS08340 ENOG4105CV8 reductase AS53_RS08345 ENOG4105F27 Major Facilitator AS53_RS08350 ENOG4105KVH Transcriptional regulator AS53_RS08365 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AS53_RS08370 ENOG4105D4A Cell wall formation (By similarity) AS53_RS08380 ENOG4105C8Q Methyl-accepting chemotaxis AS53_RS08390 ENOG4105WMR Protein CrcB homolog AS53_RS08395 ENOG4105WMR Protein CrcB homolog AS53_RS08410 ENOG4108MK9 spermidine N(1)-acetyltransferase AS53_RS08430 ENOG4108IPW abc transporter atp-binding protein AS53_RS08435 ENOG4105CM4 permease protein AS53_RS08450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS08460 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AS53_RS08470 ENOG4105XZU Preprotein translocase, subunit SecG AS53_RS08475 ENOG41067MG lrgb family AS53_RS08575 ENOG4105EFC phage portal protein HK97 family AS53_RS08600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AS53_RS08610 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AS53_RS08615 ENOG4105CP7 Triose-phosphate isomerase AS53_RS08640 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_RS08660 ENOG41090VF Stage v sporulation protein ac AS53_RS08665 ENOG4105CZ3 stage V sporulation protein ad AS53_RS08680 ENOG4105H67 Protein of unknown function (DUF421) AS53_RS08685 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AS53_RS08690 ENOG4105KRI phosphocarrier protein (HPr AS53_RS08700 ENOG4105CHW UPF0052 protein AS53_RS08710 ENOG4108Z4K mutator MutT protein AS53_RS08720 ENOG4105C3M thioredoxin reductase AS53_RS08730 ENOG4108S4C acetyltransferase AS53_RS08750 ENOG41086DT Membrane protein of unknown function AS53_RS08760 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AS53_RS08765 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AS53_RS08770 ENOG4105D7V transposase AS53_RS08785 ENOG4107TXC Transcriptional regulator AS53_RS08810 ENOG4105HMI Membrane AS53_RS08815 ENOG4105DUM transcriptional regulator, lysR family AS53_RS08825 ENOG4108WS4 fmn reductase AS53_RS08840 ENOG4105BZ1 (ABC) transporter AS53_RS08850 ENOG4105CN1 protease AS53_RS08855 ENOG4105CRP Part of the ABC transporter FtsEX involved in AS53_RS08860 ENOG4105CAK Cell division ATP-binding protein ftsE AS53_RS08880 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AS53_RS08885 ENOG4105MS2 ribosomal subunit Interface protein AS53_RS08890 ENOG4105VEQ Cold shock protein AS53_RS08895 ENOG41081UC Inherit from COG: Competence protein AS53_RS08910 ENOG4105KVH Transcriptional regulator AS53_RS08925 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AS53_RS08930 ENOG4108KGH TRANSCRIPTIONal AS53_RS08935 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AS53_RS08940 ENOG4105C6Y Udp-glucose 6-dehydrogenase AS53_RS08945 ENOG4105ESV Glycosyl transferase, family 4 AS53_RS08955 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AS53_RS08970 ENOG410901P UPF0249 protein AS53_RS08975 ENOG4105F8D glycoside hydrolase family 4 AS53_RS08980 ENOG4105VCP PTS System AS53_RS08985 ENOG4105CK1 PTS System AS53_RS08995 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AS53_RS09000 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AS53_RS09005 ENOG4105VCP PTS System AS53_RS09015 ENOG4105VZJ PTS System AS53_RS09030 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_RS09035 ENOG4105ECB domain protein AS53_RS09040 ENOG4107RSM transcriptional regulator AS53_RS09080 ENOG4105DAA L-lactate AS53_RS09090 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AS53_RS09100 ENOG4105E0M Sulfatase AS53_RS09125 ENOG4107R8N Glycosyl transferase, family 2 AS53_RS09135 ENOG4105C94 Transporter AS53_RS09140 ENOG41069ER domain protein AS53_RS09165 ENOG4105KBK Zinc finger, swim domain protein AS53_RS09170 ENOG4105C0D helicase AS53_RS09200 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_RS09210 ENOG4107RBB ABC transporter, permease AS53_RS09215 ENOG4105C19 ABC transporter AS53_RS09235 ENOG4105CXY transporter AS53_RS09250 ENOG4105BZU Histidine kinase AS53_RS09255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS09260 ENOG4105CMR udp-glucose 4-epimerase AS53_RS09275 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AS53_RS09335 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AS53_RS09350 ENOG4105FRN stage II sporulation protein AS53_RS09390 ENOG4106778 Protein of unknown function (DUF1146) AS53_RS09395 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AS53_RS09400 ENOG4105C8S subunit m AS53_RS09405 ENOG4105D65 subunit l AS53_RS09430 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AS53_RS09435 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AS53_RS09450 ENOG4105BZU Histidine kinase AS53_RS09500 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AS53_RS09505 ENOG41062M3 atp synthase AS53_RS09535 ENOG4108YZG isomerase AS53_RS09550 ENOG4108VGI doxx family AS53_RS09555 ENOG4107XC4 flavin reductase domain protein, FMN-binding AS53_RS09570 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AS53_RS09580 ENOG4108ZXQ stage ii sporulation protein r AS53_RS09585 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AS53_RS09605 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AS53_RS09610 ENOG4105CBT Fructose-1,6-bisphosphatase AS53_RS09650 ENOG4105C1G acyl-Coa dehydrogenase AS53_RS09655 ENOG4105C1G acyl-Coa dehydrogenase AS53_RS09660 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AS53_RS09670 ENOG4105DF6 Fe-S oxidoreductase AS53_RS09685 ENOG4105BZU Histidine kinase AS53_RS09705 ENOG4105BZU Histidine kinase AS53_RS09710 ENOG4105KCT ABC transporter AS53_RS09715 ENOG4108M15 ABC transporter AS53_RS09720 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AS53_RS09740 ENOG4105IIU Aminopeptidase AS53_RS09760 ENOG4105EMN RNA polymerase sigma factor AS53_RS09770 ENOG410684U Domain of unknown function (DUF1934) AS53_RS09795 ENOG4105CYW agmatinase AS53_RS09805 ENOG4105DXB Major Facilitator superfamily AS53_RS09810 ENOG4107SWG transcriptional regulator MERR family AS53_RS09815 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AS53_RS09820 ENOG4105BZ4 penicillin-binding protein AS53_RS09825 ENOG4108XFG YwhD family AS53_RS09830 ENOG4108Z4T Peptidase M50 AS53_RS09835 ENOG41069HH 4-oxalocrotonate tautomerase AS53_RS09840 ENOG4105DCI Phosphohydrolase AS53_RS09845 ENOG4108MES Periplasmic binding protein AS53_RS09850 ENOG4105E0A ABC, transporter AS53_RS09855 ENOG4105EHG Permease protein AS53_RS09875 ENOG4108VCI transcription factor, rsfa family AS53_RS09890 ENOG4108IJ2 phosphate acetyltransferase AS53_RS09905 ENOG4108VKI Cell wall hydrolase AS53_RS09925 ENOG4107SVH Potassium channel protein AS53_RS09935 ENOG410667J hydrolase AS53_RS09940 ENOG4105VCH membrane AS53_RS09950 ENOG4108TU7 Inherit from COG: (ABC) transporter AS53_RS09955 ENOG4105CJ1 ABC, transporter AS53_RS09960 ENOG41090WU lipolytic protein G-D-S-L family AS53_RS09975 ENOG4105D6E homoserine dehydrogenase AS53_RS10000 ENOG4108Y4K DNA-binding transcriptional activator AS53_RS10010 ENOG4105WH1 Two component transcriptional regulator luxr family AS53_RS10020 ENOG4105DWF phosphomethylpyrimidine kinase AS53_RS10025 ENOG4105BZU Histidine kinase AS53_RS10030 ENOG4105VCD cytoplasmic protein AS53_RS10035 ENOG4105D22 carbon starvation protein AS53_RS10040 ENOG4105DY9 regulatoR AS53_RS10045 ENOG41079KZ Major Facilitator Superfamily AS53_RS10065 ENOG4105EN6 Membrane AS53_RS10070 ENOG4106YBV Methyl-accepting chemotaxis AS53_RS10080 ENOG4108S4H thioesterase Superfamily protein AS53_RS10090 ENOG4105JEU Glycosyl transferase, family 2 AS53_RS10095 ENOG4105C5H ABC transporter AS53_RS10120 ENOG4105CKK Glycosyl transferase, family 2 AS53_RS10125 ENOG41067SE Tetr family transcriptional regulator AS53_RS10135 ENOG4105E0X reductase AS53_RS10140 ENOG4106F5Q Membrane AS53_RS10155 ENOG4105DY9 regulatoR AS53_RS10160 ENOG4108HRK Histidine kinase AS53_RS10165 ENOG4107RGD Major Facilitator superfamily AS53_RS10180 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS53_RS10190 ENOG4105IW1 AmiS UreI transporter AS53_RS10200 ENOG4105CMR udp-glucose 4-epimerase AS53_RS10205 ENOG4108UT2 hemolysin iii AS53_RS10215 ENOG4105C1J atp-dependent rna helicase AS53_RS10250 ENOG4105C0H protease AS53_RS10255 ENOG4105Q2H domain protein AS53_RS10270 ENOG4105BZU Histidine kinase AS53_RS10275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS10305 ENOG4105CDU Replicative dna helicase AS53_RS10315 ENOG4105BZR domain protein AS53_RS10320 ENOG4108XMW Membrane AS53_RS10330 ENOG4108UUM single-stranded DNA-binding protein AS53_RS10340 ENOG4105C3G gtp-binding protein AS53_RS10345 ENOG4105VDK protein, conserved in bacteria AS53_RS10350 ENOG4105D8X mechanosensitive ion channel AS53_RS10355 ENOG4108ZDA Sporulation protein YyaC AS53_RS10360 ENOG4105FA0 parb-like partition protein AS53_RS10365 ENOG4107QJE Chromosome Partitioning Protein AS53_RS10395 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AS53_RS10415 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AS53_RS10420 ENOG410848D S4 domain protein YaaA AS53_RS10435 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AS53_RS10460 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AS53_RS10495 ENOG4105ZMH deoxynucleoside kinase AS53_RS10505 ENOG4105GTG Isochorismatase AS53_RS10515 ENOG4108Z6B deaminase AS53_RS10520 ENOG4105C6E dna polymerase iii AS53_RS10540 ENOG41067KS pro-sigma K processing AS53_RS10575 ENOG4105CXN decarboxylase AS53_RS10585 ENOG4105FA2 dna polymerase iii AS53_RS10590 ENOG4105MA4 psp1 domain protein AS53_RS10600 ENOG41060K3 Methyltransferase AS53_RS10610 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AS53_RS10615 ENOG4105KRN Transcriptional regulator, abrb family AS53_RS10630 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AS53_RS10640 ENOG4105XFA sporulation peptidase YabG AS53_RS10645 ENOG4105W42 Veg protein AS53_RS10660 ENOG4105DFT pur operon repressor AS53_RS10665 ENOG4105KME endoribonuclease L-psp AS53_RS10695 ENOG4108JA2 transcriptioN-repair coupling factor AS53_RS10700 ENOG4108M14 stage v sporulation protein t AS53_RS10710 ENOG4108IY2 MazG family AS53_RS10715 ENOG41082I2 s4 domain protein AS53_RS10720 ENOG4105VYY sporulation protein yabp AS53_RS10735 ENOG41060GV RNA binding s1 domain protein AS53_RS10755 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AS53_RS10760 ENOG4108UGV hypoxanthine phosphoribosyltransferase AS53_RS10765 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AS53_RS10780 ENOG4105C6T cysteine synthase AS53_RS10785 ENOG4105CRQ synthase (Component I) AS53_RS10790 ENOG4105DDQ anthranilate synthase AS53_RS10795 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AS53_RS10800 ENOG4105EEI dihydropteroate synthase AS53_RS10805 ENOG4105KRF dihydroneopterin aldolase AS53_RS10810 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AS53_RS10820 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AS53_RS10850 ENOG4108Z0C Uvrb UvrC protein AS53_RS10865 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AS53_RS10875 ENOG4105CTP PilT protein domain protein AS53_RS10895 ENOG4105D7W serine acetyltransferase AS53_RS10910 ENOG4105C2N RNA methyltransferase TrmH family group 3 AS53_RS10915 ENOG4105M0M Tetracycline resistance protein AS53_RS10920 ENOG4105QIV RNA polymerase AS53_RS10935 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AS53_RS10960 ENOG4107Y49 methyltransferase AS53_RS10970 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AS53_RS10975 ENOG4105XPM ribosomal protein AS53_RS11105 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AS53_RS11115 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AS53_RS11160 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AS53_RS11190 ENOG4105D1F ATP-binding protein AS53_RS11205 ENOG4108NMV polysaccharide deacetylase AS53_RS11290 ENOG4105C8B TIGR00159 family AS53_RS11295 ENOG4107U5W ybbr family AS53_RS11310 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AS53_RS11315 ENOG4108VQT Alpha beta hydrolase fold protein AS53_RS11335 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AS53_RS11340 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AS53_RS11380 ENOG4108UMI ABC transporter, permease AS53_RS11385 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AS53_RS11390 ENOG4105D01 (LipO)protein AS53_RS11405 ENOG4105IQ5 FAD linked oxidase domain protein AS53_RS11420 ENOG4105C2C drug resistance transporter, Bcr CflA AS53_RS11435 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AS53_RS11440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS53_RS11445 ENOG4105C3U ABC transporter AS53_RS11450 ENOG4108JQ7 (ABC) transporter AS53_RS11480 ENOG4108J59 Extracellular solute-binding protein, family 5 AS53_RS11485 ENOG4108J59 Extracellular solute-binding protein, family 5 AS53_RS11495 ENOG4105II7 pyrroline-5-carboxylate reductase AS53_RS11505 ENOG4107XDY Nicotinamide Mononucleotide Transporter AS53_RS11515 ENOG4105E0C molybdate abc transporter AS53_RS11530 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AS53_RS11545 ENOG4105EGI Transcriptional regulator AS53_RS11560 ENOG4105F6E Acyl-transferase AS53_RS11580 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AS53_RS11595 ENOG4108RE7 deoxyribonuclease AS53_RS11600 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AS53_RS11625 ENOG4105C5H ABC transporter AS53_RS11640 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AS53_RS11650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS53_RS11655 ENOG4105C3U ABC transporter AS53_RS11660 ENOG4108JQ7 (ABC) transporter AS53_RS11695 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AS53_RS11700 ENOG4105ERH Fumarylacetoacetate hydrolase AS53_RS11710 ENOG4108SC4 )-transporter AS53_RS11725 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AS53_RS11740 ENOG4107ZXI Rhomboid family AS53_RS11750 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AS53_RS11755 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AS53_RS11765 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AS53_RS11865 ENOG4105K8N protein family UPF0079, ATPase AS53_RS11870 ENOG41072GX Peptidase M22 Glycoprotease AS53_RS11875 ENOG410801F ribosomal-protein-alanine acetyltransferase AS53_RS11885 ENOG4105C5H ABC transporter AS53_RS11900 ENOG4108TYN CAAX amino terminal protease family protein AS53_RS11920 ENOG4105C7N Xanthine uracil vitamin C permease AS53_RS11930 ENOG4105BZU Histidine kinase AS53_RS11960 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AS53_RS12020 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_RS12040 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AS53_RS12045 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AS53_RS12050 ENOG4105C83 adenylosuccinate lyase AS53_RS12060 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AS53_RS12085 ENOG4108V3E phosphoribosylglycinamide formyltransferase AS53_RS12095 ENOG4105C12 Phosphoribosylglycinamide synthetase AS53_RS12120 ENOG4105C4R Atp-dependent dna helicase AS53_RS12150 ENOG4108W2Y isochorismatase AS53_RS12155 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AS53_RS12160 ENOG4108UMI ABC transporter, permease AS53_RS12165 ENOG4105D01 (LipO)protein AS53_RS12185 ENOG410834F Transcriptional regulator AS53_RS12210 ENOG4105CBD Diacylglycerol kinase AS53_RS12215 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AS53_RS12220 ENOG4108JPW Aminotransferase AS53_RS12230 ENOG4105C26 Dehydrogenase AS53_RS12235 ENOG4105KPY Small multidrug resistance protein AS53_RS12255 ENOG4105D9N nucleoside AS53_RS12260 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AS53_RS12275 ENOG4108W15 Protein of unknown function (DUF1456) AS53_RS12290 ENOG4105DTQ mandelate racemase muconate lactonizing AS53_RS12300 ENOG4105DFD Na H antiporter AS53_RS12320 ENOG4105D3R alkyl hydroperoxide reductase AS53_RS12340 ENOG4105EHG Permease protein AS53_RS12345 ENOG4105DQ5 transport system permease protein AS53_RS12350 ENOG4108V5C ABC transporter AS53_RS12375 ENOG4106UIA AS53_RS12380 ENOG4106UIA AS53_RS12405 ENOG4105BZU Histidine kinase AS53_RS12425 ENOG410756H nucleotidyltransferase AS53_RS12430 ENOG4105D2S major facilitator superfamily AS53_RS12445 ENOG4105E5Q amino acid AbC transporter AS53_RS12450 ENOG4105EAB amino acid AbC transporter AS53_RS12465 ENOG4105C8Q Methyl-accepting chemotaxis AS53_RS12470 ENOG4105C8Q Methyl-accepting chemotaxis AS53_RS12480 ENOG4105CI1 PTS System AS53_RS12510 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AS53_RS12525 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AS53_RS12540 ENOG4105C5H ABC transporter AS53_RS12565 ENOG41062JF Transcriptional regulator AS53_RS12585 ENOG4105DEU major facilitator superfamily AS53_RS12600 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AS53_RS12615 ENOG4108N0M stress protein AS53_RS12620 ENOG4106FN3 tellurium resistance protein AS53_RS12625 ENOG4106FN3 tellurium resistance protein AS53_RS12630 ENOG4107TS3 membrane protein, TerC AS53_RS12635 ENOG4108TTB tellurium resistance protein AS53_RS12655 ENOG4105KJF protein tyrosine phosphatase AS53_RS12665 ENOG4107U9T Pfam:Ribonuclease_BN AS53_RS12670 ENOG4105C59 p-type ATPase AS53_RS12675 ENOG4108IPJ Membrane AS53_RS12695 ENOG4107ZTW SNARE associated Golgi AS53_RS12710 ENOG410606W general stress protein AS53_RS12715 ENOG4105UPD Calcium Proton AS53_RS12755 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AS53_RS12760 ENOG4105VTR Integrase AS53_RS12765 ENOG4108IMY Transcriptional regulator AS53_RS13040 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AS53_RS13050 ENOG4108JUB Transcriptional regulator AS53_RS13060 ENOG4108IQI permease AS53_RS13105 ENOG4108A04 Beta-lactamase AS53_RS13120 ENOG4105CKK Glycosyl transferase, family 2 AS53_RS13130 ENOG4107QQG Dehydrogenase AS53_RS13135 ENOG4105C3I Nad-dependent epimerase dehydratase AS53_RS13155 ENOG4105F1A Pyruvate formate-lyase AS53_RS13175 ENOG4105CI2 imidazolone-5-propionate hydrolase AS53_RS13180 ENOG4105ECP epimerase AS53_RS13210 ENOG41067AE Membrane-bound metal-dependent hydrolase AS53_RS13215 ENOG4105CEN a g-specific adenine glycosylase AS53_RS13220 ENOG4106BXE AS53_RS13240 ENOG4105BZ1 (ABC) transporter AS53_RS13245 ENOG4107NBY Membrane AS53_RS13250 ENOG4105CBC glutamate synthase AS53_RS13260 ENOG4108IUW ABC transporter AS53_RS13280 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AS53_RS13285 ENOG4105G5W regulator Fur family AS53_RS13365 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AS53_RS13400 ENOG4108JQC penicillin-binding protein 1A AS53_RS13405 ENOG4107ZQN disulfide bond AS53_RS13415 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AS53_RS13425 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AS53_RS13430 ENOG4105BZU Histidine kinase AS53_RS13440 ENOG4105CYN Serine protein kinase AS53_RS13465 ENOG4105C94 Transporter AS53_RS13480 ENOG4105DZ6 Band 7 protein AS53_RS13490 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AS53_RS13495 ENOG4108MRH transcriptional regulatory protein AS53_RS13500 ENOG4105D4T Citrate transporter AS53_RS13520 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AS53_RS13525 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS53_RS13530 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AS53_RS13535 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AS53_RS13540 ENOG4105BZ7 extracellular solute-binding protein family 1 AS53_RS13545 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AS53_RS13550 ENOG4108STX response regulator AS53_RS13555 ENOG4105US7 Histidine kinase AS53_RS13580 ENOG4108MRH transcriptional regulatory protein AS53_RS13590 ENOG4105C6K Malic enzyme AS53_RS13600 ENOG4108UZ3 Transporter AS53_RS13605 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AS53_RS13620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS13630 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AS53_RS13635 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AS53_RS13640 ENOG4108JB9 formate dehydrogenase AS53_RS13660 ENOG4105CUB amino acid AS53_RS13675 ENOG4105DAP Nicotinate phosphoribosyltransferase AS53_RS13705 ENOG41073R8 VanW family AS53_RS13710 ENOG4108KGH TRANSCRIPTIONal AS53_RS13715 ENOG4105D9N nucleoside AS53_RS13720 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AS53_RS13725 ENOG4105C37 (CBS) domain AS53_RS13730 ENOG4108IJ0 Aspartate ammonia-lyase AS53_RS13735 ENOG4105DAA L-lactate AS53_RS13750 ENOG4105DUX Transporter AS53_RS13755 ENOG4108MES Periplasmic binding protein AS53_RS13760 ENOG4105DQ5 transport system permease protein AS53_RS13765 ENOG4108IHU transport system permease protein AS53_RS13770 ENOG4105E0A ABC, transporter AS53_RS13775 ENOG4105DMQ Methyltransferase AS53_RS13785 ENOG4105EXW epimerase dehydratase AS53_RS13795 ENOG4107T89 von Willebrand factor, type A AS53_RS13800 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AS53_RS13805 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS53_RS13820 ENOG4105BZU Histidine kinase AS53_RS13825 ENOG4105D5Q Arginine ornithine antiporter AS53_RS13830 ENOG4107414 GntR family transcriptional regulator AS53_RS13835 ENOG4105C5Y PTS System AS53_RS13840 ENOG4105CG3 alpha amylase, catalytic region AS53_RS13855 ENOG4105E1K spore germination protein AS53_RS13865 ENOG4105CRN Aminoglycoside phosphotransferase AS53_RS13870 ENOG4105BZG amino acid carrier protein AS53_RS13875 ENOG4105CDA abc transporter atp-binding protein AS53_RS13880 ENOG4105CT1 (ABC) transporter AS53_RS13885 ENOG4105EAD ABC transporter AS53_RS13890 ENOG4105DRP amino acid AbC transporter AS53_RS13895 ENOG4108IQI permease AS53_RS13920 ENOG4105D29 Helix-turn-helix type 11 domain protein AS53_RS13925 ENOG4105NAE bifunctional deaminase-reductase domain protein AS53_RS13930 ENOG4105BZU Histidine kinase AS53_RS13935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS13945 ENOG4105CHH sulfate transporter AS53_RS13950 ENOG41068KF Universal stress protein AS53_RS13960 ENOG4105DEF Extracellular solute-binding protein, family 5 AS53_RS13970 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AS53_RS13975 ENOG4108JQ7 (ABC) transporter AS53_RS13985 ENOG4105CXY transporter AS53_RS13990 ENOG41067TZ transcriptional regulator, MarR family AS53_RS14005 ENOG4105ETE Transcriptional regulator (LacI family AS53_RS14010 ENOG4108RVA ribokinase AS53_RS14025 ENOG4105CNN ABC, transporter AS53_RS14030 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AS53_RS14095 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AS53_RS14100 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AS53_RS14105 ENOG41069ER domain protein AS53_RS14110 ENOG4105VZ8 Transcriptional regulator AS53_RS14115 ENOG4107D63 AS53_RS14125 ENOG4105DUX Transporter AS53_RS14145 ENOG4105C85 amino acid AS53_RS14150 ENOG4105C7N Xanthine uracil vitamin C permease AS53_RS14190 ENOG4105BZ9 Cytochrome C oxidase, subunit I AS53_RS14195 ENOG4105E2S oxidase) subunit II AS53_RS14200 ENOG4108IQI permease AS53_RS14215 ENOG4106CAD Protein of unknown function (DUF3311) AS53_RS14220 ENOG4105E1V na solute symporter AS53_RS14235 ENOG4108NHD germination protein AS53_RS14245 ENOG4105CE1 Ferrous iron transport protein b AS53_RS14250 ENOG4105CE1 Ferrous iron transport protein b AS53_RS14255 ENOG4105CE1 Ferrous iron transport protein b AS53_RS14260 ENOG4105CVA phosphate AS53_RS14265 ENOG4105C8U phosphate abc transporter AS53_RS14270 ENOG4105E2Z phosphate ABC transporter (Permease AS53_RS14345 ENOG41080XQ Signal transduction protein with cbs domains AS53_RS14370 ENOG4105ETU transcriptional activator (TenA AS53_RS14380 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AS53_RS14390 ENOG4108VEU Thiamine monophosphate synthase AS53_RS14395 ENOG41080HI glycine oxidase AS53_RS14410 ENOG4105D06 uba thif-type nad fad binding protein AS53_RS14415 ENOG4105DWF phosphomethylpyrimidine kinase AS53_RS14465 ENOG4108INS Transcriptional regulator AS53_RS14480 ENOG4105C7N Xanthine uracil vitamin C permease AS53_RS14510 ENOG4105C5Y PTS System AS53_RS14570 ENOG4107Y03 Nitroreductase AS53_RS14575 ENOG4105ED1 spovr family AS53_RS14600 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AS53_RS14605 ENOG4105XTG Pfam:DUF156 AS53_RS14610 ENOG4105VFE sira family AS53_RS14615 ENOG4107TPS domain protein AS53_RS14620 ENOG4105VFE sira family AS53_RS14625 ENOG41085GJ domain protein AS53_RS14635 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AS53_RS14640 ENOG41087NI Sulfite exporter TauE/SafE AS53_RS14650 ENOG4108KGH TRANSCRIPTIONal AS53_RS14675 ENOG4105EMD TRANSCRIPTIONal AS53_RS14680 ENOG4105VCP PTS System AS53_RS14685 ENOG4105VZJ PTS System AS53_RS14705 ENOG41069ER domain protein AS53_RS14710 ENOG4107RBB ABC transporter, permease AS53_RS14715 ENOG4105C19 ABC transporter AS53_RS14745 ENOG4105WEF catalase AS53_RS14780 ENOG4107T5V SNARE associated Golgi AS53_RS14815 ENOG4105CUB amino acid AS53_RS14820 ENOG4107RWR Sodium hydrogen exchanger AS53_RS14830 ENOG4106KNT transcriptional regulator AS53_RS14865 ENOG4108PCN EamA-like transporter family AS53_RS14870 ENOG4108YXU transcriptional regulator AsnC family AS53_RS14885 ENOG4105KPY Small multidrug resistance protein AS53_RS14910 ENOG4105NF4 modulator of drug activity AS53_RS14915 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AS53_RS14920 ENOG4105E5W Transporter AS53_RS14930 ENOG4107RKG DJ-1/PfpI family AS53_RS14935 ENOG4105CH6 catalase AS53_RS14945 ENOG4105D5Q Arginine ornithine antiporter AS53_RS14950 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AS53_RS14960 ENOG4105C26 Dehydrogenase AS53_RS14970 ENOG4105BZ1 (ABC) transporter AS53_RS14985 ENOG4105DRP amino acid AbC transporter AS53_RS14990 ENOG4105CDA abc transporter atp-binding protein AS53_RS15005 ENOG410839P AS53_RS15040 ENOG4107FQX Alpha-acetolactate decarboxylase AS53_RS15070 ENOG4105D4P Coproporphyrinogen iii oxidase AS53_RS15085 ENOG4105CHH sulfate transporter AS53_RS15125 ENOG4106AKK s-layer domain-containing protein AS53_RS15135 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AS53_RS15140 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AS53_RS15155 ENOG4105CGU Enoyl-CoA hydratase AS53_RS15175 ENOG4105DER m42 family AS53_RS15195 ENOG4105CTU Proline racemase AS53_RS15240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS53_RS15250 ENOG4108JQ7 (ABC) transporter AS53_RS15255 ENOG4105PKS Excinuclease abc c subunit domain protein AS53_RS15285 ENOG4105CSH Transporter AS53_RS15295 ENOG4108MRH transcriptional regulatory protein AS53_RS15345 ENOG4105CDU Replicative dna helicase AS53_RS15385 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_RS15435 ENOG4107P5I polyketide synthase AS53_RS15440 ENOG4108IG5 Transcriptional regulator AS53_RS15460 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AS53_RS15480 ENOG4105CMT Dihydroxyacetone kinase AS53_RS15495 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AS53_RS15500 ENOG410847I Transcriptional regulator, BadM Rrf2 family AS53_RS15525 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AS53_RS15590 ENOG4105WN5 stage II sporulation protein AS53_RS15600 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AS53_RS15610 ENOG4108MJI response regulator AS53_RS15615 ENOG4105BZU Histidine kinase AS53_RS15620 ENOG4105BZU Histidine kinase AS53_RS15680 ENOG4107VRP DNA repair exonuclease AS53_RS15690 ENOG4105D7V transposase AS53_RS15705 ENOG4108IND Tetr family transcriptional regulator AS53_RS15710 ENOG4105EQ0 Major Facilitator superfamily AS53_RS15720 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AS53_RS15730 ENOG4108MUZ hydrolase AS53_RS15750 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AS53_RS15765 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AS53_RS15780 ENOG4105EMN RNA polymerase sigma factor AS53_RS15805 ENOG4105C57 major facilitator superfamily AS53_RS15810 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_RS15820 ENOG4105EEM helicase AS53_RS15855 ENOG4105K59 histidine triad (HIT) protein AS53_RS15885 ENOG410905X membrane-flanked domain protein AS53_RS15935 ENOG410905X membrane-flanked domain protein AS53_RS15940 ENOG4105CKV Membrane AS53_RS15945 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AS53_RS15950 ENOG4105BZ4 penicillin-binding protein AS53_RS15955 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AS53_RS15965 ENOG4105C1Q protoporphyrinogen oxidase AS53_RS15990 ENOG4105NA0 Transcriptional regulator AS53_RS16005 ENOG4105ECB domain protein AS53_RS16035 ENOG4106AXD AS53_RS16040 ENOG4108RQ5 Beta-lactamase domain-containing protein AS53_RS16045 ENOG4105DF9 Lipoate-protein, ligase AS53_RS16055 ENOG4105CEY Amp-dependent synthetase and ligase AS53_RS16085 ENOG4105CNA YD repeat protein AS53_RS16135 ENOG4107TVP HD domain protein AS53_RS16145 ENOG4108AEY RNA polymerase sigma factor AS53_RS16150 ENOG41086D8 Transcriptional regulator AS53_RS16170 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_RS16195 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AS53_RS16200 ENOG4105C8Q Methyl-accepting chemotaxis AS53_RS16225 ENOG4107QP3 malate synthase g AS53_RS16255 ENOG4105XVF Competence transcription factor AS53_RS16270 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AS53_RS16275 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AS53_RS16320 ENOG4105ERH Fumarylacetoacetate hydrolase AS53_RS16345 ENOG4105CAQ asparagine synthetase AS53_RS16350 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AS53_RS16355 ENOG4105CH6 catalase AS53_RS16360 ENOG4105BZU Histidine kinase AS53_RS16385 ENOG4105QNR S1 RNA binding domain protein AS53_RS16395 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AS53_RS16405 ENOG4107AYK membrAne AS53_RS16410 ENOG41073B9 AS53_RS16420 ENOG4108KP7 hydrolase AS53_RS16435 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AS53_RS16460 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AS53_RS16465 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AS53_RS16480 ENOG4105C31 Tryptophanyl-tRNA synthetase AS53_RS16495 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AS53_RS16500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AS53_RS16510 ENOG4108JQ7 (ABC) transporter AS53_RS16515 ENOG4105UQX Mate efflux family protein AS53_RS16540 ENOG4108ZCF integral membrane protein AS53_RS16550 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS53_RS16560 ENOG4105DPN Oligoendopeptidase f AS53_RS16575 ENOG4108Z18 K06886 hemoglobin AS53_RS16580 ENOG4105MIX Adenylate cyclase AS53_RS16600 ENOG4105EMS pseudouridine synthase AS53_RS16620 ENOG4105K64 Glycosyl transferase, family 2 AS53_RS16640 ENOG4107TVC Glycosyl transferase, family 2 AS53_RS16660 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AS53_RS16665 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AS53_RS16675 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AS53_RS16750 ENOG4105CK7 Sodium proline symporter AS53_RS16765 ENOG4105DDQ anthranilate synthase AS53_RS16855 ENOG4105C7S Dehydrogenase AS53_RS16865 ENOG4105VZ8 Transcriptional regulator AS53_RS16925 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AS53_RS16935 ENOG4105DZ1 carboxypeptidase AS53_RS16940 ENOG4105VFR signal peptidase AS53_RS16975 ENOG4105C26 Dehydrogenase AS53_RS16980 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS53_RS16985 ENOG4105F38 ABC transporter, permease AS53_RS16990 ENOG4105D38 putrescine abc transporter AS53_RS16995 ENOG4107RUE extracellular solute-binding protein family 1 AS53_RS17005 ENOG4105EYF MMPL domain protein AS53_RS17015 ENOG4108YBP pseudouridine synthase AS53_RS17025 ENOG4105K4I Scp-like extracellular AS53_RS17030 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AS53_RS17035 ENOG4105CQB FAD linked oxidase domain protein AS53_RS17050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS17055 ENOG4105BZU Histidine kinase AS53_RS17060 ENOG4105JXH GntR family transcriptional regulator AS53_RS17080 ENOG4106A3R peptidase AS53_RS17090 ENOG4108QTI )-transporter AS53_RS17095 ENOG4107TS3 membrane protein, TerC AS53_RS17100 ENOG4105CZN Potassium uptake protein AS53_RS17105 ENOG410681C small acid-soluble spore protein AS53_RS17110 ENOG4108Z7G MaoC domain protein dehydratase AS53_RS17130 ENOG4105CHR reductase AS53_RS17140 ENOG4105MWK D-amino acid dehydrogenase, small subunit AS53_RS17160 ENOG4105C4Y ABC transporter AS53_RS17190 ENOG4105E98 transcriptional regulator DeoR family AS53_RS17215 ENOG4105PXI polysaccharide deacetylase AS53_RS17225 ENOG4105BZU Histidine kinase AS53_RS17230 ENOG41090MY MarR family Transcriptional regulator AS53_RS17240 ENOG4106DF1 AS53_RS17250 ENOG4105BZU Histidine kinase AS53_RS17260 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AS53_RS17265 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AS53_RS17310 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AS53_RS17330 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AS53_RS17335 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AS53_RS17340 ENOG4105CZV ABC transporter AS53_RS17350 ENOG4105CJ1 ABC, transporter AS53_RS17390 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AS53_RS17395 ENOG4105EA8 2-Nitropropane dioxygenase AS53_RS17400 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AS53_RS17410 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AS53_RS17435 ENOG4105NQC Flavodoxin AS53_RS17470 ENOG4107QMU Mate efflux family protein AS53_RS17475 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AS53_RS17505 ENOG4105CZN Potassium uptake protein AS53_RS17510 ENOG41063Y9 AS53_RS17515 ENOG4105KBJ sporulation protein ytfj AS53_RS17545 ENOG4105CM2 brancheD-chain amino acid aminotransferase AS53_RS17550 ENOG4105C7K acetolactate synthase AS53_RS17555 ENOG4108ZP8 Acetolactate synthase small subunit AS53_RS17560 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AS53_RS17570 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AS53_RS17595 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AS53_RS17630 ENOG4107RVV histidinol phosphate phosphatase, hisj family AS53_RS17645 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AS53_RS17650 ENOG4105E0M Sulfatase AS53_RS17660 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AS53_RS17680 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AS53_RS17685 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AS53_RS17695 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AS53_RS17700 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AS53_RS17705 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AS53_RS17715 ENOG4105C8J )-transporter AS53_RS17735 ENOG4105DFD Na H antiporter AS53_RS17755 ENOG4105ENE Histidine kinase AS53_RS17760 ENOG4105WH1 Two component transcriptional regulator luxr family AS53_RS17780 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AS53_RS17805 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AS53_RS17830 ENOG4105CJ3 phosphate transporter AS53_RS17835 ENOG4107GRR phosphate transport regulator AS53_RS17840 ENOG4105BZ4 penicillin-binding protein AS53_RS17855 ENOG4105BZU Histidine kinase AS53_RS17860 ENOG4105I3N Conserved Protein AS53_RS17875 ENOG4105BZU Histidine kinase AS53_RS17910 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AS53_RS17915 ENOG4105DZ1 carboxypeptidase AS53_RS17920 ENOG4108JIC nucleoside recognition domain protein AS53_RS17930 ENOG4105FE9 pseudouridine synthase AS53_RS17940 ENOG4107TWT Cytochrome c biogenesis protein AS53_RS17945 ENOG4105CRE cytochrome C AS53_RS17950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS17955 ENOG4105BZU Histidine kinase AS53_RS17960 ENOG4108WBT adenosyltransferase AS53_RS17975 ENOG4108SAX Membrane AS53_RS17985 ENOG4105T7X AS53_RS17990 ENOG4105C9U ATP-dependent DNA helicase RecQ AS53_RS17995 ENOG4105I7S Abortive infection protein AS53_RS18010 ENOG4107X2D transcriptional regulator, merr family AS53_RS18015 ENOG4108S6Z Negative regulator of genetic competence AS53_RS18040 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AS53_RS18045 ENOG4105HDK L-asparaginase AS53_RS18080 ENOG4105S2F AS53_RS18085 ENOG41065D1 AS53_RS18115 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AS53_RS18130 ENOG4105XXQ heptaprenyl diphosphate synthase component I AS53_RS18140 ENOG4105EAH synthase AS53_RS18160 ENOG4105CIH Imidazole acetol-phosphate transaminase AS53_RS18165 ENOG41068YB TPR repeat-containing protein AS53_RS18180 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AS53_RS18185 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AS53_RS18190 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AS53_RS18220 ENOG4108JYZ YitT family AS53_RS18225 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AS53_RS18240 ENOG4105FJR Lmbe family AS53_RS18245 ENOG4105CPK Glycosyl transferase (Group 1 AS53_RS18285 ENOG4105DVT helicase AS53_RS18290 ENOG4105YAC AS53_RS18310 ENOG4105CSM endonuclease III AS53_RS18320 ENOG4105BZ4 penicillin-binding protein AS53_RS18370 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AS53_RS18380 ENOG4105DVT helicase AS53_RS18385 ENOG4105CTD carboxy-peptidase AS53_RS18400 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AS53_RS18410 ENOG4105C2W permease AS53_RS18415 ENOG4105DHF Membrane AS53_RS18420 ENOG410890F Dynamin family AS53_RS18430 ENOG4108W0I acetyltransferase AS53_RS18440 ENOG4105KHC sulfurtransferase AS53_RS18515 ENOG4105CPK Glycosyl transferase (Group 1 AS53_RS18530 ENOG4108SZE gCN5-related N-acetyltransferase AS53_RS18550 ENOG41081VK Ribonuclease AS53_RS18615 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS53_RS18625 ENOG4107RWR Sodium hydrogen exchanger AS53_RS18630 ENOG4105CN5 Metallo-Beta-Lactamase AS53_RS18635 ENOG4108Z5V transcriptional regulator, merr family AS53_RS18645 ENOG4105H67 Protein of unknown function (DUF421) AS53_RS18650 ENOG41080C8 DUF218 domain AS53_RS18705 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AS53_RS18715 ENOG4107R0U MotA TolQ exbB proton channel AS53_RS18720 ENOG4105ER2 Ompa motb domain protein AS53_RS18725 ENOG4107YTP response regulator receiver protein AS53_RS18735 ENOG4105DD5 Flagellar motor switch protein AS53_RS18750 ENOG4105BZU Histidine kinase AS53_RS18770 ENOG4105E1Q flagellar hook-associated protein AS53_RS18800 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AS53_RS18805 ENOG4108ZC9 flagellar basal-body rod protein flgc AS53_RS18825 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AS53_RS18860 ENOG4105BZE flagellar hook protein, FlgE AS53_RS18875 ENOG4107R88 Chemotaxis protein (CheV) AS53_RS18885 ENOG4105K64 Glycosyl transferase, family 2 AS53_RS18940 ENOG4105I03 Flagellin AS53_RS18945 ENOG4105E4C Lytic transglycosylase catalytic AS53_RS18960 ENOG4105DD5 Flagellar motor switch protein AS53_RS18970 ENOG4105CN7 Flagellar biosynthetic protein FliP AS53_RS18975 ENOG4105VS8 Flagellar biosynthetic protein fliq AS53_RS18985 ENOG4105D00 flagellar biosynthetic protein flhB AS53_RS18990 ENOG4105D7B Flagellar biosynthesis protein flha AS53_RS18995 ENOG4105FZW flagellar biosynthesis regulator FlhF AS53_RS19000 ENOG4105KTQ flagellar basal-body rod protein AS53_RS19005 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AS53_RS19030 ENOG4108RZE Tetr family transcriptional regulator AS53_RS19050 ENOG4105KAC Antibiotic biosynthesis monooxygenase AS53_RS19080 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AS53_RS19085 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AS53_RS19090 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AS53_RS19095 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AS53_RS19130 ENOG4105CVJ phosphoglycerate mutase AS53_RS19160 ENOG4105CAQ asparagine synthetase AS53_RS19180 ENOG4105PGM cation diffusion facilitator family transporter AS53_RS19190 ENOG4105DRR Transcriptional regulator, GntR family AS53_RS19195 ENOG4108UZ3 Transporter AS53_RS19200 ENOG4105CKI cobalamin synthesis protein AS53_RS19205 ENOG4108PJD permease AS53_RS19220 ENOG4105DFD Na H antiporter AS53_RS19225 ENOG4105C9Q fumarate hydratase class II AS53_RS19275 ENOG4107QIV Cytochrome c biogenesis protein AS53_RS19310 ENOG4106BRA Membrane AS53_RS19345 ENOG4105CJ1 ABC, transporter AS53_RS19365 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AS53_RS19375 ENOG4108IJ0 Aspartate ammonia-lyase AS53_RS19380 ENOG4105C6K Malic enzyme AS53_RS19450 ENOG4105FVX AS53_RS19490 ENOG4105CSR polyphosphate kinase 2 AS53_RS19510 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AS53_RS19525 ENOG4105EU0 Major facilitator Superfamily AS53_RS19530 ENOG4105C6T cysteine synthase AS53_RS19550 ENOG4105C8J )-transporter AS53_RS19560 ENOG4105X5K response regulator receiver protein AS53_RS19565 ENOG4105H67 Protein of unknown function (DUF421) AS53_RS19580 ENOG4106KE4 Dehydrogenase AS53_RS19595 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AS53_RS19600 ENOG4105CHR reductase AS53_RS19605 ENOG4105CM2 brancheD-chain amino acid aminotransferase AS53_RS19610 ENOG4105C7K acetolactate synthase AS53_RS19615 ENOG4108ZP8 Acetolactate synthase small subunit AS53_RS19620 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AS53_RS19630 ENOG4105C7B Threonine dehydratase AS53_RS19655 ENOG4105C6X Major Facilitator AS53_RS19660 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AS53_RS19670 ENOG4105DY9 regulatoR AS53_RS19675 ENOG4105CYC Transferase AS53_RS19695 ENOG4105F6J Alpha beta hydrolase fold AS53_RS19730 ENOG41068WN AS53_RS19750 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AS53_RS19765 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AS53_RS19800 ENOG4107RHR regulatoR AS53_RS19810 ENOG4105D9N nucleoside AS53_RS19815 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AS53_RS19850 ENOG4107RAQ aminopeptidase AS53_RS19855 ENOG4107STQ Multicopper oxidase AS53_RS19900 ENOG4108T5E Copper resistance protein AS53_RS19905 ENOG4105KTB nuclear export factor GLE1 AS53_RS19915 ENOG4107RT3 EamA-like transporter family AS53_RS19920 ENOG4105GZI Transcriptional regulator AS53_RS19925 ENOG4108Z40 Transcriptional regulator AS53_RS19930 ENOG4107ZXU DSBA oxidoreductase AS53_RS19935 ENOG4108TVJ Nitroreductase AS53_RS19945 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AS53_RS19950 ENOG4106F5Q Membrane AS53_RS19965 ENOG4105CKI cobalamin synthesis protein AS53_RS19985 ENOG4108Z7G MaoC domain protein dehydratase AS53_RS19990 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AS53_RS20000 ENOG4105C0Z ABC transporter AS53_RS20005 ENOG4108IV0 ABC, transporter AS53_RS20010 ENOG4105C32 Amino acid ABC transporter (Permease) AS53_RS20020 ENOG4105SKE transcriptional Regulator LysR family AS53_RS20030 ENOG4105MDS 4-oxalocrotonate tautomerase AS53_RS20040 ENOG4105YGB Transcriptional regulator AS53_RS20050 ENOG4105C4M (Ubiquinol oxidase) subunit I AS53_RS20055 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AS53_RS20060 ENOG4108JJ9 ABC, transporter AS53_RS20065 ENOG4108JJ8 (ABC) transporter AS53_RS20120 ENOG4105EFI regulatoR AS53_RS20125 ENOG4105BZU Histidine kinase AS53_RS20145 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AS53_RS20170 ENOG4105D6E homoserine dehydrogenase AS53_RS20195 ENOG4108KGH TRANSCRIPTIONal AS53_RS20205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AS53_RS20210 ENOG4105BZU Histidine kinase AS53_RS20225 ENOG4105KT7 mgtC SapB transporter AS53_RS20230 ENOG4105VRR gCN5-related N-acetyltransferase AS53_RS20240 ENOG4105DUU IucA IucC family protein AS53_RS20245 ENOG4105CEY Amp-dependent synthetase and ligase AS53_RS20260 ENOG4108WBH protein TIM barrel AS53_RS20265 ENOG4105YWU small acid-soluble spore protein AS53_RS20275 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AS53_RS20325 ENOG4105KRN Transcriptional regulator, abrb family AS53_RS20335 ENOG4105YVS arsR family transcriptional regulator AS53_RS20340 ENOG4107SET aldo keto reductase AS53_RS20345 ENOG4107XZQ multidrug resistance protein AS53_RS20370 ENOG4105C8Q Methyl-accepting chemotaxis AS53_RS20390 ENOG4108K88 Membrane AS53_RS20395 ENOG4108WPJ Ferritin-like domain AS53_RS20410 ENOG4105DEN Luciferase family AS53_RS20430 ENOG4107QM2 Aldo Keto reductase AS53_RS20435 ENOG4105CKI cobalamin synthesis protein AS53_RS20500 ENOG4105DSE periplasmic solute binding protein AS53_RS20510 ENOG4105K4T epimerase AS53_RS20520 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AS53_RS20545 ENOG4105CVJ phosphoglycerate mutase AS53_RS20565 ENOG4107T5V SNARE associated Golgi AS53_RS20580 ENOG4108PJD permease AS53_RS20590 ENOG4108S4H thioesterase Superfamily protein AS53_RS20595 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AS53_RS20615 ENOG4105SXS Protein of unknown function (DUF456) AS53_RS20620 ENOG4105C37 (CBS) domain AS53_RS20640 ENOG4108Z7R Chaperone CsaA AS53_RS20660 ENOG4108ZRV stage ii sporulation protein p AS53_RS20670 ENOG4108VXD carboxy-peptidase AS53_RS20680 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AS53_RS20705 ENOG4108X4Q Hydrolase AS53_RS20715 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AS53_RS20735 ENOG41087PP glycosyltransferase MGT family AS53_RS20740 ENOG4108JYZ YitT family AS53_RS20745 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AS53_RS20770 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AS53_RS20820 ENOG4105KBJ sporulation protein ytfj AS53_RS20845 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AS53_RS20870 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_RS20880 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AS53_RS20885 ENOG4105EMN RNA polymerase sigma factor AS53_RS20910 ENOG4108V06 Glutathione peroxidase AS53_RS20925 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AS53_RS20945 ENOG4108IUE nitrate reductase beta subunit AS53_RS20950 ENOG4105R3A Nitrate reductase AS53_RS20975 ENOG4107V6Q Cyclic nucleotide-binding domain AS53_RS20980 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AS53_RS20985 ENOG4105D06 uba thif-type nad fad binding protein AS53_RS20990 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS53_RS20995 ENOG4108ZAF Molybdopterin AS53_RS21020 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AS53_RS21025 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AS53_RS21030 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AS53_RS21035 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AS53_RS21040 ENOG4108IFG nitrite reductase, (NAD(P)H) AS53_RS21045 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AS53_RS21080 ENOG4105MCT stage V sporulation protein S AS53_RS21095 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AS53_RS21115 ENOG4105C5H ABC transporter AS53_RS21130 ENOG4108UUM single-stranded DNA-binding protein AS53_RS21165 ENOG4107YX5 Pfam:DUF548 AS53_RS21170 ENOG4105C75 arginyL-tRNA synthetase AS53_RS21195 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AS53_RS21215 ENOG4105C5S asparaginyl-tRNA synthetase AS53_RS21235 ENOG4105EC2 ftsk spoIIIe AS53_RS21330 ENOG4105BZW Glycerate kinase AS53_RS21335 ENOG4107QPK )-transporter AS53_RS21340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS21345 ENOG41062D9 Histidine kinase AS53_RS21360 ENOG4105C8J )-transporter AS53_RS21380 ENOG4107XGZ Hydrolase AS53_RS21385 ENOG4105CY2 Citrate transporter AS53_RS21390 ENOG4105C0A alcohol dehydrogenase AS53_RS21405 ENOG4105KD7 acetyltransferase AS53_RS21435 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AS53_RS21455 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AS53_RS21470 ENOG4107RVG penicillin-binding protein AS53_RS21475 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AS53_RS21480 ENOG4105E9Q Acyl-transferase AS53_RS21485 ENOG4108UT2 hemolysin iii AS53_RS21495 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AS53_RS21505 ENOG4108RCR degv family AS53_RS21510 ENOG4105E8R UPF0173 metal-dependent hydrolase AS53_RS21515 ENOG4108KF3 Electron transport protein SCO1 SenC AS53_RS21520 ENOG4107Y70 Heat shock protein AS53_RS21525 ENOG4105CAQ asparagine synthetase AS53_RS21545 ENOG4108MES Periplasmic binding protein AS53_RS21550 ENOG4105F0I Aminotransferase AS53_RS21585 ENOG4105D8X mechanosensitive ion channel AS53_RS21590 ENOG4105BZU Histidine kinase AS53_RS21595 ENOG4105WH1 Two component transcriptional regulator luxr family AS53_RS21640 ENOG4105CMG Carbohydrate kinase AS53_RS21645 ENOG4105CMG Carbohydrate kinase AS53_RS21675 ENOG4108IJ8 ABC transporter AS53_RS21680 ENOG4105E90 ABC transporter AS53_RS21715 ENOG4105C37 (CBS) domain AS53_RS21740 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AS53_RS21755 ENOG4107S4Y M20 DapE family protein YgeY AS53_RS21760 ENOG4108TSC N-acetyltransferase AS53_RS21765 ENOG4108JUB Transcriptional regulator AS53_RS21770 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AS53_RS21810 ENOG4108N23 SpoOM-related protein AS53_RS21815 ENOG410841Q phosphoesterase PA-phosphatase related protein AS53_RS21825 ENOG4105SZ6 Thioredoxin AS53_RS21840 ENOG4108IBT Inherit from COG: transposase AS53_RS21945 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AS53_RS21985 ENOG4105BZ4 penicillin-binding protein AS53_RS21990 ENOG4105CZM Major Facilitator AS53_RS21995 ENOG4105W8X HesB YadR YfhF-family protein AS53_RS22005 ENOG4105DXD 2-methylcitrate dehydratase AS53_RS22010 ENOG4105CR4 methylisocitrate lyase AS53_RS22015 ENOG4105C1G acyl-Coa dehydrogenase AS53_RS22020 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AS53_RS22030 ENOG4105N14 lysine exporter protein LysE YggA AS53_RS22035 ENOG4105E39 Enoyl-CoA hydratase AS53_RS22050 ENOG4107RFY SbcCD D subunit AS53_RS22055 ENOG4105EYH Exonuclease AS53_RS22085 ENOG4105FCD Major Facilitator AS53_RS22090 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AS53_RS22095 ENOG4105E4F Isochorismate synthase AS53_RS22100 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AS53_RS22105 ENOG4105WQI isochorismatase AS53_RS22110 ENOG4105CEY Amp-dependent synthetase and ligase AS53_RS22115 ENOG4105WQT MbtH domain protein AS53_RS22120 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_RS22135 ENOG4105K70 DNA-binding protein AS53_RS22155 ENOG4105BZG amino acid carrier protein AS53_RS22180 ENOG4105FE9 pseudouridine synthase AS53_RS22185 ENOG4105C22 threonyL-tRNA synthetase AS53_RS22200 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AS53_RS22225 ENOG4108D32 Methyltransferase AS53_RS22255 ENOG41081I9 integral membrane protein AS53_RS22270 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AS53_RS22280 ENOG4105EYF MMPL domain protein AS53_RS22305 ENOG4105WCN acetyltransferase AS53_RS22335 ENOG4105C1Q protoporphyrinogen oxidase AS53_RS22345 ENOG41068WN AS53_RS22355 ENOG4105VEQ Cold shock protein AS53_RS22375 ENOG410667J hydrolase AS53_RS22420 ENOG4107V2S Transcriptional regulator AS53_RS22425 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AS53_RS22440 ENOG4105DND Transcriptional regulator AS53_RS22445 ENOG4108RPX mosc domain containing protein AS53_RS22460 ENOG4105BZ1 (ABC) transporter AS53_RS22465 ENOG4105BZ1 (ABC) transporter AS53_RS22485 ENOG4108JCI Transcriptional regulator AS53_RS22510 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B AS53_RS22515 ENOG4108KPJ rna polymerase sigma factor AS53_RS22540 ENOG4105F32 YngK protein AS53_RS22565 ENOG4105RD7 BadF BadG BcrA BcrD AS53_RS22575 ENOG4107STF Involved in phosphonate degradation (By similarity) AS53_RS22595 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AS53_RS22610 ENOG4105C1J atp-dependent rna helicase AS53_RS22625 ENOG4108RZE Tetr family transcriptional regulator AS53_RS22645 ENOG41088CC tellurite resistance protein tehB AS53_RS22655 ENOG4108I0C methyltransferase AS53_RS22660 ENOG4107RA9 decarboxylase AS53_RS22665 ENOG41090HR transcriptional regulator AS53_RS22705 ENOG4105CIN aminoacyl-histidine dipeptidase AS53_RS22730 ENOG4107RF6 penicillin-binding protein AS53_RS22745 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AS53_RS22750 ENOG4105ETE Transcriptional regulator (LacI family AS53_RS22755 ENOG4105IE8 Alpha-ketoglutarate permease AS53_RS22760 ENOG4105CK5 oxidoreductase AS53_RS22785 ENOG4105D2N Aldolase AS53_RS22790 ENOG4105DH8 myo-inositol catabolism AS53_RS22825 ENOG4105VZ8 Transcriptional regulator AS53_RS22840 ENOG4108VXD carboxy-peptidase AS53_RS22860 ENOG41067SE Tetr family transcriptional regulator AS53_RS22865 ENOG4105C5H ABC transporter AS53_RS22875 ENOG4105BZU Histidine kinase AS53_RS22885 ENOG4106ANW SMI1_KNR4 AS53_RS22890 ENOG4105CEP NADH dehydrogenase AS53_RS22895 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AS53_RS22910 ENOG4105CJ1 ABC, transporter AS53_RS22920 ENOG4107Z3H Transcriptional regulator, TetR family AS53_RS22935 ENOG4105C1G acyl-Coa dehydrogenase AS53_RS22940 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AS53_RS22945 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AS53_RS22950 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AS53_RS22955 ENOG4105E39 Enoyl-CoA hydratase AS53_RS22960 ENOG4107QX3 carboxylase AS53_RS22965 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AS53_RS22975 ENOG4105WCN acetyltransferase AS53_RS22980 ENOG4105DBI uridine monophosphokinase AS53_RS22995 ENOG4105DZ1 carboxypeptidase AS53_RS23010 ENOG4105T9C HD domain AS53_RS23020 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AS53_RS23060 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AS53_RS23060 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AS53_RS23075 ENOG4105FQP Beta-lactamase AS53_RS23085 ENOG4107Y80 Major Facilitator superfamily AS53_RS23105 ENOG4105CUV Homoserine Kinase AS53_RS23140 ENOG4105CPQ Dehydrogenase AS53_RS23255 ENOG4105ETU transcriptional activator (TenA AS53_RS23365 ENOG410667J hydrolase AS53_RS23375 ENOG4105BZU Histidine kinase AS53_RS23380 ENOG4107RF6 penicillin-binding protein AS53_RS23400 ENOG4108JJB ABC transporter AS53_RS23410 ENOG4108HGU Histidine kinase AS53_RS23425 ENOG4105CB2 alcohol dehydrogenase AS53_RS23430 ENOG4105CJN penicillin-binding protein AS53_RS23440 ENOG4105FQP Beta-lactamase AS53_RS23475 ENOG4108V4B ThiJ pfpI AS53_RS23505 ENOG4107Y80 Major Facilitator superfamily AS53_RS23520 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AS53_RS23540 ENOG4107Y9U Membrane AS53_RS23575 ENOG4105FCD Major Facilitator AS53_RS23590 ENOG4105E09 nadh pyrophosphatase AS53_RS23595 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AS53_RS23600 ENOG4108Z4K mutator MutT protein AS53_RS23635 ENOG4108XI2 Domain of unknown function (DUF1963) AS53_RS23670 ENOG4105KWG Pfam:DUF1696 AS53_RS23705 ENOG4105PKS Excinuclease abc c subunit domain protein AS53_RS23745 ENOG4107VFR oxidoreductase AS53_RS23770 ENOG4105PAD Hydrolase AS53_RS23790 ENOG4105DY8 decarboxylase AS53_RS23805 ENOG4108IUM Glycogen debranching enzyme AS53_RS23830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AS53_RS23840 ENOG4105FDR Membrane AS53_RS23875 ENOG4108V3A UPF0421 protein AS53_RS23895 ENOG4105MSI germination protein ypeb AS53_RS23915 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AS53_RS23920 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AS53_RS23925 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AS53_RS23930 ENOG4107Z3H Transcriptional regulator, TetR family AS53_RS23960 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AS53_RS23980 ENOG4105E98 transcriptional regulator DeoR family AS53_RS24000 ENOG41062ES Transcriptional regulator AS53_RS24020 ENOG4107QKR Dehydrogenase AS53_RS24030 ENOG4107RUY (E1 component), alpha subunit AS53_RS24040 ENOG4105E1F short-chain dehydrogenase reductase AS53_RS24045 ENOG4105RHY Pfam:UPF0157 AS53_RS24080 ENOG4107SQ8 Glycine betaine AS53_RS24085 ENOG4108IJ7 Glycine betaine AS53_RS24110 ENOG4105E66 phosphoriboisomerase A AS53_RS24115 ENOG41082BV acetyltransferase AS53_RS24120 ENOG4108M1A Chitin-binding protein AS53_RS24165 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AS53_RS24215 ENOG4105EEM helicase AS53_RS24235 ENOG4105C9U ATP-dependent DNA helicase RecQ AS53_RS24290 ENOG4108M1A Chitin-binding protein AS53_RS24305 ENOG4105BZG amino acid carrier protein AS53_RS24310 ENOG4105C26 Dehydrogenase AS53_RS24315 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AS53_RS24320 ENOG4105CTU Proline racemase AS53_RS24325 ENOG4105CTU Proline racemase AS53_RS24330 ENOG41080HI glycine oxidase AS53_RS24370 ENOG4107T5V SNARE associated Golgi AS53_RS24385 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AS53_RS24390 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AS53_RS24405 ENOG4105DTQ mandelate racemase muconate lactonizing AS53_RS24445 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AS53_RS24450 ENOG4105BZU Histidine kinase AS53_RS24490 ENOG4105DPN Oligoendopeptidase f AS53_RS24495 ENOG4105EPR degv family AS53_RS24535 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AS53_RS24540 ENOG4106K7D Major facilitator family transporter AS53_RS24560 ENOG4107BMA Transglycosylase associated protein AS53_RS24575 ENOG41089UC methyltransferase, type 11 AS53_RS24610 ENOG4105CHM Aminotransferase AS53_RS24640 ENOG4105DVE abc transporter atp-binding protein AS53_RS24690 ENOG4105C02 permease AS53_RS24705 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AS53_RS24710 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AS53_RS24715 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AS53_RS24740 ENOG4105E09 nadh pyrophosphatase AS53_RS24760 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AS53_RS24810 ENOG4107VC0 DNA alkylation repair enzyme AS53_RS24830 ENOG4108ZCF integral membrane protein AS53_RS24835 ENOG4105E0M Sulfatase AS53_RS24840 ENOG4105C5H ABC transporter AS53_RS24850 ENOG4105EYF MMPL domain protein AS53_RS24860 ENOG4105EYF MMPL domain protein AS53_RS24865 ENOG41082JN Transcriptional regulator AS53_RS24885 ENOG4105CIH Imidazole acetol-phosphate transaminase AS53_RS24890 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AS53_RS24895 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AS53_RS24915 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) AS53_RS24930 ENOG41069ER domain protein AS53_RS24940 ENOG4105EMN RNA polymerase sigma factor AS53_RS24965 ENOG4105D4B ABC, transporter AS53_RS24975 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AS53_RS24985 ENOG4105DKT Transcriptional regulator AS53_RS25000 ENOG41061GT Aldolase AS53_RS25020 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AS53_RS25050 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AS53_RS25055 ENOG4105II7 pyrroline-5-carboxylate reductase AS53_RS25065 ENOG4107258 Transcriptional regulator AS53_RS25075 ENOG4105E0Y RtcB Protein AS53_RS25080 ENOG4105ECK Fatty Acid Desaturase AS53_RS25085 ENOG4105G6Z alkaline phosphatase AS53_RS25095 ENOG4105VMP Transcriptional regulator AS53_RS25110 ENOG41090T1 Membrane AS53_RS25120 ENOG4108WCX response regulator AS53_RS25130 ENOG41068WN AS53_RS25155 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AS53_RS25170 ENOG4105CSH Transporter AS53_RS25180 ENOG4105CKK Glycosyl transferase, family 2 AS53_RS25205 ENOG4105CKK Glycosyl transferase, family 2 AS53_RS25215 ENOG4105C8Y Acetylornithine aminotransferase AS53_RS25255 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AS53_RS25265 ENOG4108TVJ Nitroreductase AS53_RS25270 ENOG4105FS7 Transcriptional regulator AS53_RS25305 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AS53_RS25315 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AS53_RS25345 ENOG4108XET gCN5-related N-acetyltransferase AS53_RS25425 ENOG410635A Membrane AS53_RS25430 ENOG4105KNA -acetyltransferase AS53_RS25435 ENOG4108IQI permease AS53_RS25445 ENOG4105F1N DNA alkylation repair AS53_RS25485 ENOG4107RF6 penicillin-binding protein AS53_RS25495 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AS53_RS25530 ENOG4105P4J Allophanate hydrolase, subunit 1 AS53_RS25535 ENOG4107258 Transcriptional regulator AS53_RS25545 ENOG4106N3A copper homeostasis protein cutc AS53_RS25550 ENOG4108ZRV stage ii sporulation protein p AS53_RS25555 ENOG4108ZHR arsR family transcriptional regulator AS53_RS25565 ENOG4105FDT acyl-CoA dehydrogenase AS53_RS25585 ENOG4105DWD nucleoside recognition domain protein AS53_RS25615 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AS53_RS25680 ENOG4105E2A Dehydrogenase AS53_RS25695 ENOG4108IJ0 Aspartate ammonia-lyase AS53_RS25700 ENOG4105HDK L-asparaginase AS53_RS25705 ENOG4108IMY Transcriptional regulator AS53_RS25715 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AS53_RS25720 ENOG4105CUB amino acid AS53_RS25730 ENOG4105II7 pyrroline-5-carboxylate reductase AS53_RS25740 ENOG4105C6K Malic enzyme AS53_RS25760 ENOG4108Q8B Spore germination protein AS53_RS25780 ENOG4105CSV Glutaminase AS53_RS25810 ENOG4105CGH 5'-nucleotidase AS53_RS25815 ENOG4105CH6 catalase AS53_RS25825 ENOG4105CHJ isochorismatase hydrolase AS53_RS25890 ENOG4108606 TspO/MBR family AS53_RS25895 ENOG4105CVP deoxyribo-dipyrimidine photolyase AS53_RS25910 ENOG4108TWJ NADH dehydrogenase subunit 5 AS53_RS25915 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AS53_RS25925 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AS53_RS25930 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AS53_RS25935 ENOG4105DSE periplasmic solute binding protein AS53_RS25940 ENOG4105CC5 ABC transporter AS53_RS25945 ENOG4105DIK (ABC) transporter AS53_RS25975 ENOG4105D6J arsenicaL-resistance protein AS53_RS25980 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_RS25985 ENOG41085FC arsR family transcriptional regulator AS53_RS26000 ENOG4105F7F Chaperone AS53_RS26010 ENOG4105CHR reductase AS53_RS26015 ENOG4108YXU transcriptional regulator AsnC family AS53_RS26090 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AS53_RS26100 ENOG4105C0R drug resistance transporter emrb qaca subfamily AS53_RS26110 ENOG4105IIP Membrane AS53_RS26125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS26130 ENOG41062D9 Histidine kinase AS53_RS26160 ENOG4105K6H D-cysteine desulfhydrase AS53_RS26185 ENOG4105VZ8 Transcriptional regulator AS53_RS26200 ENOG4108NNI Beta-lactamase domain-containing protein AS53_RS26205 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AS53_RS26215 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AS53_RS26220 ENOG4105JQZ Methyltransferase AS53_RS26235 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AS53_RS26240 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AS53_RS26260 ENOG4105BZU Histidine kinase AS53_RS26275 ENOG4108U05 Transcriptional regulator AS53_RS26290 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AS53_RS26295 ENOG4105DJB Major Facilitator Superfamily AS53_RS26300 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AS53_RS26305 ENOG4107QR9 Iron-sulfur cluster binding protein AS53_RS26315 ENOG4106P55 Transcriptional regulator AS53_RS26325 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AS53_RS26360 ENOG4105TRI Hydrolase AS53_RS26395 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AS53_RS26425 ENOG4107QJQ Mate efflux family protein AS53_RS26440 ENOG4105EQ0 Major Facilitator superfamily AS53_RS26445 ENOG4108JGH Tetr family transcriptional regulator AS53_RS26460 ENOG4105C44 Serine transporter AS53_RS26465 ENOG4105EJQ L-serine dehydratase AS53_RS26480 ENOG4108JPW Aminotransferase AS53_RS26495 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AS53_RS26505 ENOG4105DVH amino acid AS53_RS26520 ENOG4108JQ1 Dehydrogenase AS53_RS26540 ENOG4108AEY RNA polymerase sigma factor AS53_RS26555 ENOG41082W1 Cupin 2, conserved barrel domain protein AS53_RS26565 ENOG410874W AraC family transcriptional regulator AS53_RS26620 ENOG4108ISG Major Facilitator AS53_RS26630 ENOG4107MII Sugar-specific transcriptional regulator TrmB AS53_RS26635 ENOG4105CZM Major Facilitator AS53_RS26655 ENOG4105DA5 (ABC) transporter AS53_RS26660 ENOG41069JR AS53_RS26670 ENOG4105RXJ AS53_RS26675 ENOG4105KPY Small multidrug resistance protein AS53_RS26680 ENOG4105KBX Transcriptional regulator, TetR family AS53_RS26695 ENOG4105CRW Short chain fatty acid transporter AS53_RS26705 ENOG4105DYS nad(p)h dehydrogenase (quinone) AS53_RS26735 ENOG4108JJB ABC transporter AS53_RS26740 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AS53_RS26765 ENOG4108K8S endonuclease I AS53_RS26780 ENOG41067QW Transcriptional regulator AS53_RS26790 ENOG4108Z66 YbaK ebsC protein AS53_RS26795 ENOG4105CUT histidyl-tRNA synthetase AS53_RS26810 ENOG4105KVH Transcriptional regulator AS53_RS26815 ENOG4108RCM Nitroreductase AS53_RS26835 ENOG4108PSK reductase AS53_RS26845 ENOG4105CJ1 ABC, transporter AS53_RS26905 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_RS26910 ENOG4105DKQ ROK family AS53_RS26915 ENOG4106UW1 Major Facilitator superfamily AS53_RS26920 ENOG4108UW5 maltose o-acetyltransferase AS53_RS26930 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AS53_RS26940 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AS53_RS26965 ENOG4105DMQ Methyltransferase AS53_RS26975 ENOG4105EV4 Multidrug resistance protein mdtH AS53_RS27005 ENOG4105C37 (CBS) domain AS53_RS27020 ENOG4105DDN Pentapeptide repeat-containing protein AS53_RS27025 ENOG4105XDF Protein of unknown function (DUF1272) AS53_RS27030 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AS53_RS27035 ENOG4105CMG Carbohydrate kinase AS53_RS27040 ENOG4105C6Z Gluconate AS53_RS27045 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AS53_RS27060 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AS53_RS27065 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AS53_RS27070 ENOG4105CIS alcohol dehydrogenase AS53_RS27075 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AS53_RS27095 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AS53_RS27100 ENOG4105D4Y metalloprotease AS53_RS27120 ENOG4105CV8 reductase AS53_RS27125 ENOG4105F27 Major Facilitator AS53_RS27140 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AS53_RS27145 ENOG4105C44 Serine transporter AS53_RS27180 ENOG4105KVH Transcriptional regulator AS53_RS27185 ENOG4108TZY GntR Family Transcriptional Regulator AS53_RS27195 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AS53_RS27200 ENOG4105KVH Transcriptional regulator AS53_RS27205 ENOG4105KVH Transcriptional regulator AS53_RS27240 ENOG4105JAB phenazine biosynthesis protein, phzf family AS53_RS27250 ENOG4105CHR reductase AS53_RS27270 ENOG4105KVH Transcriptional regulator AS53_RS27340 ENOG4105KAF membrAne AS53_RS27365 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AS53_RS27380 ENOG4107YXZ hydrolase, family 25 AS53_RS27415 ENOG4105H3G oxidoreductase AS53_RS27450 ENOG4105CIS alcohol dehydrogenase AS53_RS27490 ENOG4108TN2 lmbE family AS53_RS27500 ENOG4107R3E Citrate transporter AS53_RS27520 ENOG4108MES Periplasmic binding protein AS53_RS27530 ENOG4105EHG Permease protein AS53_RS27535 ENOG4105DQ5 transport system permease protein AS53_RS27540 ENOG4105NX3 Membrane AS53_RS27545 ENOG4107ZY0 Phenazine biosynthesis-like protein AS53_RS27565 ENOG4107CUJ Protein of unknown function (DUF2690) AS53_RS27575 ENOG4107V2S Transcriptional regulator AS53_RS27595 ENOG4105C98 muts2 protein AS53_RS27605 ENOG4105E5K Alpha-amylase AS53_RS27620 ENOG4108A04 Beta-lactamase AS53_RS27650 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AS53_RS27675 ENOG41082BM Transcriptional regulator, arsr family AS53_RS27680 ENOG4105CIS alcohol dehydrogenase AS53_RS27705 ENOG4105RHY Pfam:UPF0157 AS53_RS27715 ENOG4105C09 Bile acid AS53_RS27720 ENOG4105CQB FAD linked oxidase domain protein AS53_RS27745 ENOG4108UT6 Transferase hexapeptide repeat containing protein AS53_RS27765 ENOG4105E39 Enoyl-CoA hydratase AS53_RS27775 ENOG4105KT7 mgtC SapB transporter AS53_RS27785 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AS53_RS27790 ENOG41073R8 VanW family AS53_RS27800 ENOG4108R1P AS53_RS27820 ENOG4105VEQ Cold shock protein AS53_RS27840 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AS53_RS27860 ENOG410904N short-chain dehydrogenase reductase AS53_RS27870 ENOG4106IQC argininosuccinate lyase AS53_RS27885 ENOG4108IA2 Sodium pantothenate symporter AS53_RS27895 ENOG4105C26 Dehydrogenase AS53_RS27900 ENOG4105CHR reductase AS53_RS27910 ENOG4105EWU Squalene--hopene cyclase AS53_RS27920 ENOG4105FR1 rard protein AS53_RS27925 ENOG410696E Membrane AS53_RS27940 ENOG4105D1F ATP-binding protein AS53_RS27950 ENOG4108ZAF Molybdopterin AS53_RS27955 ENOG4105CVM Molybdenum cofactor synthesis domain protein AS53_RS27960 ENOG4105D06 uba thif-type nad fad binding protein AS53_RS27965 ENOG4105TMB Formate nitrite transporter AS53_RS27975 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AS53_RS27980 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AS53_RS28000 ENOG4105E1K spore germination protein AS53_RS28060 ENOG4107QJT sodium dicarboxylate symporter AS53_RS28065 ENOG4108KGH TRANSCRIPTIONal AS53_RS28075 ENOG4105EMN RNA polymerase sigma factor AS53_RS28100 ENOG4105CIG ABC transporter AS53_RS28110 ENOG4105D9R oxidoreductase AS53_RS28120 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AS53_RS28130 ENOG4105K4P CoA-binding domain protein AS53_RS28135 ENOG4105C0H protease AS53_RS28140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AS53_RS28150 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AS53_RS28155 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AS53_RS28160 ENOG4105W8X HesB YadR YfhF-family protein AS53_RS28190 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AS53_RS28195 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AS53_RS28205 ENOG4108JJA ABC, transporter AS53_RS28210 ENOG4108I0Z Aconitate hydratase AS53_RS28250 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AS53_RS28270 ENOG4107F3J Amp-dependent synthetase and ligase AS53_RS28275 ENOG4107ZYJ bioY protein AS53_RS28280 ENOG4105CEY Amp-dependent synthetase and ligase AS53_RS28325 ENOG4107AYK membrAne AS53_RS28335 ENOG4105BZU Histidine kinase AS53_RS28340 ENOG4105FBA Phospholipase Carboxylesterase AS53_RS28345 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AS53_RS28350 ENOG4105CK7 Sodium proline symporter AS53_RS28355 ENOG4105CBC glutamate synthase AS53_RS28360 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AS53_RS28365 ENOG4108VJ1 Transcriptional regulator (CarD family AS53_RS28370 ENOG4108903 Formimidoylglutamase AS53_RS28395 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AS53_RS28515 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AS53_RS28525 ENOG4108MEK Metal-binding protein YodA AS53_RS28555 ENOG4108IBT Inherit from COG: transposase AS53_RS28585 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AS53_RS28760 ENOG4105C6Y Udp-glucose 6-dehydrogenase AS53_RS28765 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AS53_RS28770 ENOG4108NV9 Glycosyl Transferase AS53_RS28790 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AS53_RS28795 ENOG4106AKK s-layer domain-containing protein AS53_RS28820 ENOG4105DHF Membrane AS53_RS29045 ENOG4105CNU cell division protein FtsK AS53_RS29110 ENOG4106JUT Streptomycin 3''-adenylyltransferase AS53_RS29160 ENOG4105EKQ RNA-directed DNA polymerase AS53_RS29240 ENOG4105EKQ RNA-directed DNA polymerase AS53_RS30190 ENOG4105CMT Dihydroxyacetone kinase AS53_RS30990 ENOG41090MY MarR family Transcriptional regulator AS53_RS31215 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AS53_RS31665 ENOG4105EYF MMPL domain protein AS53_RS31870 ENOG4105KRN Transcriptional regulator, abrb family