locus-tag	class	description
AK39_RS00405	COG0745	RESPONSE REGULATOR receiver
AK39_RS00520	COG1250	3-hydroxyacyl-CoA dehydrogenase
AK39_RS00520	COG1024	Enoyl-CoA hydratase
AK39_RS00615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AK39_RS00855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AK39_RS00865	COG0149	triose-phosphate isomerase activity
AK39_RS00870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AK39_RS00880	COG4974	Belongs to the 'phage' integrase family
AK39_RS00905	COG4695	Portal protein
AK39_RS01005	COG1346	cytolysis
AK39_RS01010	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AK39_RS01015	COG1647	Serine aminopeptidase, S33
AK39_RS01020	COG0557	exoribonuclease II activity
AK39_RS01070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_RS01085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AK39_RS01090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AK39_RS01100	COG3290	protein histidine kinase activity
AK39_RS01100	COG0840	transmembrane signaling receptor activity
AK39_RS01110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AK39_RS01115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AK39_RS01120	COG1252	NADH dehydrogenase
AK39_RS01130	COG1733	regulation of RNA biosynthetic process
AK39_RS01135	COG2814	Major facilitator Superfamily
AK39_RS01140	COG0656	L-ascorbic acid biosynthetic process
AK39_RS01155	COG2910	NAD(P)H-binding
AK39_RS01160	COG1115	amino acid carrier protein
AK39_RS01165	COG1115	amino acid carrier protein
AK39_RS01170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_RS01175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_RS01185	COG2311	Membrane
AK39_RS01200	COG1611	Belongs to the LOG family
AK39_RS01215	COG0783	Belongs to the Dps family
AK39_RS01220	COG1115	amino acid carrier protein
AK39_RS01230	COG0490	domain, Protein
AK39_RS01235	COG0475	glutathione-regulated potassium exporter activity
AK39_RS01250	COG1741	Belongs to the pirin family
AK39_RS01255	COG3227	Zinc metalloprotease (Elastase)
AK39_RS01260	COG2151	metal-sulfur cluster biosynthetic enzyme
AK39_RS01285	COG5002	protein histidine kinase activity
AK39_RS01290	COG0745	RESPONSE REGULATOR receiver
AK39_RS01295	COG1376	ErfK ybiS ycfS ynhG family protein
AK39_RS01305	COG0586	Pfam SNARE associated Golgi protein
AK39_RS01340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_RS01350	COG0706	membrane insertase activity
AK39_RS01360	COG0531	amino acid
AK39_RS01365	COG2814	Major facilitator Superfamily
AK39_RS01385	COG0840	transmembrane signaling receptor activity
AK39_RS01390	COG0011	TIGRFAM Protein of
AK39_RS01405	COG1686	Belongs to the peptidase S11 family
AK39_RS01415	COG1250	3-hydroxyacyl-CoA dehydrogenase
AK39_RS01415	COG1024	Enoyl-CoA hydratase
AK39_RS01420	COG0183	Belongs to the thiolase family
AK39_RS01430	COG1960	acyl-CoA dehydrogenase activity
AK39_RS01435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_RS01440	COG1309	transcriptional regulator
AK39_RS01465	COG0039	L-malate dehydrogenase activity
AK39_RS01515	COG1393	Belongs to the ArsC family
AK39_RS01525	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AK39_RS01530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK39_RS01545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AK39_RS01550	COG2011	ABC-type metal ion transport system permease component
AK39_RS01555	COG1464	Belongs to the NlpA lipoprotein family
AK39_RS01560	COG1464	Belongs to the NlpA lipoprotein family
AK39_RS01565	COG0396	ATPase activity
AK39_RS01570	COG0719	Fe-S assembly protein
AK39_RS01575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AK39_RS01580	COG0822	iron-sulfur transferase activity
AK39_RS01585	COG0719	Fe-S assembly protein
AK39_RS01600	COG1695	Transcriptional regulator
AK39_RS01610	COG0737	Belongs to the 5'-nucleotidase family
AK39_RS01615	COG3377	Domain of unknown function (DUF1805)
AK39_RS01625	COG0739	heme binding
AK39_RS01650	COG4377	Putative membrane peptidase family (DUF2324)
AK39_RS01655	COG0789	Transcriptional regulator
AK39_RS01665	COG4470	Protein conserved in bacteria
AK39_RS01685	COG1494	fructose-1,6-bisphosphatase
AK39_RS01690	COG2445	Protein of unknown function DUF86
AK39_RS01700	COG0647	UMP catabolic process
AK39_RS01705	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK39_RS01720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AK39_RS01725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK39_RS01735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AK39_RS01740	COG4837	Protein of unknown function (DUF1462)
AK39_RS01780	COG2824	Alkylphosphonate utilization operon protein PhnA
AK39_RS01785	COG0390	transport system, permease component
AK39_RS01800	COG1252	NADH dehydrogenase
AK39_RS01815	COG0316	Belongs to the HesB IscA family
AK39_RS01835	COG1683	Conserved Protein
AK39_RS01850	COG3708	Transcriptional regulator
AK39_RS01865	COG1252	NADH dehydrogenase
AK39_RS01880	COG3584	3D domain protein
AK39_RS01895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AK39_RS01900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AK39_RS01910	COG1268	BioY protein
AK39_RS01920	COG2050	protein possibly involved in aromatic compounds catabolism
AK39_RS01940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK39_RS01945	COG5018	Exonuclease
AK39_RS01965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AK39_RS01975	COG2267	carboxylic ester hydrolase activity
AK39_RS01980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AK39_RS01985	COG1522	sequence-specific DNA binding
AK39_RS01990	COG0436	Aminotransferase
AK39_RS01995	COG1098	S1 RNA binding domain
AK39_RS02000	COG2155	Conserved Protein
AK39_RS02010	COG0166	Belongs to the GPI family
AK39_RS02020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AK39_RS02025	COG1285	pathogenesis
AK39_RS02060	COG0544	peptidyl-prolyl cis-trans isomerase activity
AK39_RS02170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AK39_RS02175	COG0297	glycogen (starch) synthase activity
AK39_RS02180	COG0058	SHG alpha-glucan phosphorylase activity
AK39_RS02205	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AK39_RS02210	COG1575	Belongs to the MenA family. Type 1 subfamily
AK39_RS02215	COG1169	isochorismate synthase
AK39_RS02220	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AK39_RS02225	COG0596	Alpha beta hydrolase
AK39_RS02230	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AK39_RS02240	COG4948	Mandelate Racemase Muconate Lactonizing
AK39_RS02270	COG3964	amidohydrolase
AK39_RS02290	COG2188	Transcriptional regulator
AK39_RS02310	COG1136	(ABC) transporter
AK39_RS02315	COG0577	efflux transmembrane transporter activity
AK39_RS02320	COG0577	efflux transmembrane transporter activity
AK39_RS02330	COG0577	efflux transmembrane transporter activity
AK39_RS02335	COG2205	protein histidine kinase activity
AK39_RS02340	COG0745	RESPONSE REGULATOR receiver
AK39_RS02345	COG2207	Transcriptional regulator
AK39_RS02345	COG3708	Transcriptional regulator
AK39_RS02350	COG1136	(ABC) transporter
AK39_RS02355	COG0577	efflux transmembrane transporter activity
AK39_RS02365	COG0586	Pfam SNARE associated Golgi protein
AK39_RS02400	COG1597	lipid kinase activity
AK39_RS02430	COG0745	RESPONSE REGULATOR receiver
AK39_RS02435	COG5002	protein histidine kinase activity
AK39_RS02470	COG1842	Phage shock protein A
AK39_RS02495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_RS02515	COG1294	oxidase, subunit
AK39_RS02520	COG1271	oxidase subunit
AK39_RS02525	COG0288	reversible hydration of carbon dioxide
AK39_RS02555	COG0494	nUDIX hydrolase
AK39_RS02580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK39_RS02585	COG1116	anion transmembrane transporter activity
AK39_RS02590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK39_RS02610	COG2267	carboxylic ester hydrolase activity
AK39_RS02615	COG4191	Histidine kinase
AK39_RS02620	COG5002	protein histidine kinase activity
AK39_RS02625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AK39_RS02680	COG0521	Mo-molybdopterin cofactor biosynthetic process
AK39_RS02690	COG0438	transferase activity, transferring glycosyl groups
AK39_RS02695	COG0671	phosphoesterase, PA-phosphatase related
AK39_RS02700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AK39_RS02705	COG2267	carboxylic ester hydrolase activity
AK39_RS02725	COG1794	racemase activity, acting on amino acids and derivatives
AK39_RS02735	COG1131	(ABC) transporter
AK39_RS02740	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AK39_RS02745	COG1242	4 iron, 4 sulfur cluster binding
AK39_RS02765	COG1136	(ABC) transporter
AK39_RS02775	COG0582	viral genome integration into host DNA
AK39_RS02780	COG0490	domain, Protein
AK39_RS02785	COG0475	glutathione-regulated potassium exporter activity
AK39_RS02790	COG2814	Major facilitator Superfamily
AK39_RS02835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AK39_RS02845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_RS02870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK39_RS02880	COG0303	'Molybdopterin
AK39_RS02885	COG1763	Mo-molybdopterin cofactor biosynthetic process
AK39_RS02890	COG0314	molybdopterin synthase activity
AK39_RS02905	COG4975	Glucose uptake
AK39_RS02915	COG1329	Transcriptional regulator
AK39_RS02935	COG3832	glyoxalase III activity
AK39_RS02945	COG2814	Major facilitator Superfamily
AK39_RS02950	COG2081	HI0933 family
AK39_RS02955	COG2244	polysaccharide biosynthetic process
AK39_RS02960	COG1187	pseudouridine synthase activity
AK39_RS02965	COG1349	DNA-binding transcription factor activity
AK39_RS02970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK39_RS02975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK39_RS02990	COG1523	belongs to the glycosyl hydrolase 13 family
AK39_RS02995	COG0510	thiamine kinase activity
AK39_RS03010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_RS03020	COG1363	Peptidase, m42
AK39_RS03025	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AK39_RS03030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK39_RS03035	COG4848	Belongs to the UPF0354 family
AK39_RS03040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK39_RS03050	COG1674	ftsk spoiiie
AK39_RS03065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_RS03085	COG2309	aminopeptidase activity
AK39_RS03095	COG3118	belongs to the thioredoxin family
AK39_RS03100	COG4851	CamS sex pheromone cAM373 precursor
AK39_RS03110	COG1609	Transcriptional regulator
AK39_RS03145	COG0666	response to abiotic stimulus
AK39_RS03155	COG0745	RESPONSE REGULATOR receiver
AK39_RS03165	COG0123	including yeast histone deacetylase and acetoin utilization protein
AK39_RS03170	COG0517	IMP dehydrogenase activity
AK39_RS03175	COG0454	-acetyltransferase
AK39_RS03180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AK39_RS03190	COG1595	DNA-templated transcription, initiation
AK39_RS03220	COG0626	cystathionine gamma-synthase activity
AK39_RS03225	COG1956	GAF domain-containing protein
AK39_RS03235	COG0697	spore germination
AK39_RS03240	COG0583	DNA-binding transcription factor activity
AK39_RS03250	COG1104	cysteine desulfurase activity
AK39_RS03275	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AK39_RS03290	COG3874	Sporulation protein YtfJ
AK39_RS03295	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AK39_RS03300	COG0827	DNA restriction-modification system
AK39_RS03305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AK39_RS03325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_RS03365	COG0589	response to stress
AK39_RS03370	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS03385	COG1476	TRANSCRIPTIONal
AK39_RS03395	COG0662	Cupin 2, conserved barrel domain protein
AK39_RS03400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_RS03435	COG0006	proline dipeptidase activity
AK39_RS03450	COG4109	DRTGG domain
AK39_RS03470	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AK39_RS03485	COG0587	DNA-directed DNA polymerase activity
AK39_RS03490	COG0281	malic enzyme
AK39_RS03495	COG1725	Transcriptional regulator
AK39_RS03520	COG3030	protein affecting phage T7 exclusion by the F plasmid
AK39_RS03525	COG0628	permease
AK39_RS03540	COG0372	Belongs to the citrate synthase family
AK39_RS03545	COG0538	isocitrate dehydrogenase activity
AK39_RS03565	COG0745	RESPONSE REGULATOR receiver
AK39_RS03570	COG5002	protein histidine kinase activity
AK39_RS03575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK39_RS03575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK39_RS03585	COG1971	Probably functions as a manganese efflux pump
AK39_RS03590	COG0237	dephospho-CoA kinase activity
AK39_RS03595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AK39_RS03605	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AK39_RS03615	COG3611	Membrane attachment protein
AK39_RS03620	COG1484	DNA-dependent DNA replication
AK39_RS03630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AK39_RS03655	COG1363	Peptidase, m42
AK39_RS03660	COG1309	transcriptional regulator
AK39_RS03665	COG1566	PFAM secretion protein HlyD family protein
AK39_RS03670	COG2814	Major facilitator Superfamily
AK39_RS03695	COG1418	mRNA catabolic process
AK39_RS03705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AK39_RS03750	COG1286	toxin biosynthetic process
AK39_RS03755	COG1796	DNA polymerase
AK39_RS03755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AK39_RS03770	COG1187	pseudouridine synthase activity
AK39_RS03775	COG1114	Component of the transport system for branched-chain amino acids
AK39_RS03780	COG5386	Cell surface protein
AK39_RS03790	COG5386	Cell surface protein
AK39_RS03805	COG1120	ATPase activity
AK39_RS03810	COG4509	Sortase family
AK39_RS03825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AK39_RS03830	COG4895	conserved protein (DUF2196)
AK39_RS03840	COG0745	RESPONSE REGULATOR receiver
AK39_RS03845	COG2205	protein histidine kinase activity
AK39_RS03850	COG1131	(ABC) transporter
AK39_RS03880	COG2318	DinB family
AK39_RS03900	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_RS03905	COG1309	transcriptional regulator
AK39_RS03910	COG1024	Enoyl-CoA hydratase
AK39_RS03915	COG2086	electron transfer activity
AK39_RS03920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AK39_RS03925	COG3118	belongs to the thioredoxin family
AK39_RS03935	COG1719	4-vinyl reductase, 4VR
AK39_RS03940	COG2009	succinate dehydrogenase
AK39_RS03945	COG1053	succinate dehydrogenase
AK39_RS03950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AK39_RS03955	COG0824	Thioesterase
AK39_RS03960	COG1876	peptidase activity
AK39_RS03965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AK39_RS03975	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AK39_RS03980	COG4152	abc transporter atp-binding protein
AK39_RS03985	COG1668	transmembrane transport
AK39_RS03990	COG1959	2 iron, 2 sulfur cluster binding
AK39_RS04000	COG0697	spore germination
AK39_RS04005	COG1396	sequence-specific DNA binding
AK39_RS04010	COG1983	PspC domain protein
AK39_RS04025	COG3279	Response regulator of the LytR AlgR family
AK39_RS04030	COG3275	phosphorelay sensor kinase activity
AK39_RS04035	COG4608	Belongs to the ABC transporter superfamily
AK39_RS04040	COG0444	Belongs to the ABC transporter superfamily
AK39_RS04050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK39_RS04060	COG0402	S-adenosylhomocysteine deaminase activity
AK39_RS04065	COG0402	S-adenosylhomocysteine deaminase activity
AK39_RS04075	COG2233	PERMEase
AK39_RS04080	COG2197	response regulator
AK39_RS04095	COG1309	transcriptional regulator
AK39_RS04115	COG5401	PFAM Sporulation and spore germination
AK39_RS04130	COG0622	Phosphoesterase
AK39_RS04180	COG1067	ATP-dependent peptidase activity
AK39_RS04180	COG0470	DNA polymerase III
AK39_RS04195	COG1764	response to oxidative stress
AK39_RS04200	COG1846	Transcriptional regulator
AK39_RS04210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AK39_RS04220	COG1587	Uroporphyrinogen-III synthase
AK39_RS04225	COG0113	porphobilinogen synthase activity
AK39_RS04235	COG1388	LysM domain
AK39_RS04245	COG0525	valine-tRNA ligase activity
AK39_RS04250	COG0285	dihydrofolate synthase activity
AK39_RS04270	COG1077	Cell shape determining protein MreB Mrl
AK39_RS04290	COG2894	cell division
AK39_RS04295	COG0739	heme binding
AK39_RS04300	COG1994	Peptidase M50
AK39_RS04305	COG1530	ribonuclease E activity
AK39_RS04315	COG2868	ribosomal protein
AK39_RS04325	COG3290	protein histidine kinase activity
AK39_RS04330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AK39_RS04335	COG0745	RESPONSE REGULATOR receiver
AK39_RS04345	COG5002	protein histidine kinase activity
AK39_RS04350	COG1136	(ABC) transporter
AK39_RS04355	COG0577	efflux transmembrane transporter activity
AK39_RS04360	COG0577	efflux transmembrane transporter activity
AK39_RS04365	COG0077	Prephenate dehydratase
AK39_RS04370	COG2258	MOSC domain
AK39_RS04375	COG1827	regulation of RNA biosynthetic process
AK39_RS04380	COG1104	cysteine desulfurase activity
AK39_RS04385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AK39_RS04390	COG0157	Belongs to the NadC ModD family
AK39_RS04415	COG0640	Transcriptional regulator
AK39_RS04420	COG0697	spore germination
AK39_RS04425	COG0697	spore germination
AK39_RS04435	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AK39_RS04465	COG1862	Preprotein translocase
AK39_RS04475	COG2323	membrane
AK39_RS04480	COG2244	polysaccharide biosynthetic process
AK39_RS04490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AK39_RS04490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AK39_RS04495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AK39_RS04500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AK39_RS04500	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AK39_RS04510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AK39_RS04535	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AK39_RS04545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AK39_RS04550	COG1959	2 iron, 2 sulfur cluster binding
AK39_RS04555	COG1104	cysteine desulfurase activity
AK39_RS04560	COG0482	sulfurtransferase activity
AK39_RS04570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AK39_RS04590	COG0628	permease
AK39_RS04600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AK39_RS04620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AK39_RS04625	COG4122	O-methyltransferase activity
AK39_RS04630	COG0826	peptidase U32
AK39_RS04635	COG0826	peptidase U32
AK39_RS04650	COG0768	penicillin binding
AK39_RS04675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK39_RS04680	COG0626	cystathionine gamma-synthase activity
AK39_RS04685	COG1012	belongs to the aldehyde dehydrogenase family
AK39_RS04685	COG1454	alcohol dehydrogenase
AK39_RS04695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_RS04735	COG2259	Doxx family
AK39_RS04740	COG2514	catechol 2,3-dioxygenase activity
AK39_RS04745	COG2514	catechol 2,3-dioxygenase activity
AK39_RS04755	COG3186	Phenylalanine-4-hydroxylase
AK39_RS04760	COG1404	Belongs to the peptidase S8 family
AK39_RS04795	COG2267	carboxylic ester hydrolase activity
AK39_RS04805	COG1785	Belongs to the alkaline phosphatase family
AK39_RS04815	COG2357	RelA SpoT domain protein
AK39_RS04820	COG0778	Nitroreductase
AK39_RS04830	COG1595	DNA-templated transcription, initiation
AK39_RS04855	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AK39_RS04860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AK39_RS04870	COG1534	Rna-binding protein
AK39_RS04880	COG1713	HD superfamily hydrolase involved in NAD metabolism
AK39_RS04885	COG0799	negative regulation of ribosome biogenesis
AK39_RS04890	COG2226	methyltransferase
AK39_RS04895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK39_RS04900	COG1555	photosystem II stabilization
AK39_RS04900	COG1596	polysaccharide export
AK39_RS04905	COG2131	deaminase
AK39_RS04920	COG1466	dna polymerase III delta subunit
AK39_RS04945	COG1733	regulation of RNA biosynthetic process
AK39_RS04950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AK39_RS04980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AK39_RS04985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AK39_RS04990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AK39_RS04995	COG1610	YqeY-like protein
AK39_RS05015	COG1702	phosphate starvation-inducible protein PhoH
AK39_RS05020	COG1480	7TM receptor with intracellular HD hydrolase
AK39_RS05030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AK39_RS05035	COG0295	cytidine deaminase activity
AK39_RS05040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AK39_RS05055	COG0517	IMP dehydrogenase activity
AK39_RS05075	COG0358	DNA primase activity
AK39_RS05080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AK39_RS05085	COG2010	Cytochrome c
AK39_RS05090	COG2384	SAM-dependent methyltransferase
AK39_RS05095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AK39_RS05125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_RS05130	COG1121	(ABC) transporter
AK39_RS05135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AK39_RS05140	COG0735	belongs to the Fur family
AK39_RS05165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK39_RS05170	COG0477	Major facilitator Superfamily
AK39_RS05175	COG0768	penicillin binding
AK39_RS05180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AK39_RS05185	COG0573	inorganic phosphate transmembrane transporter activity
AK39_RS05190	COG0581	inorganic phosphate transmembrane transporter activity
AK39_RS05200	COG0704	Plays a role in the regulation of phosphate uptake
AK39_RS05205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AK39_RS05210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AK39_RS05215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AK39_RS05220	COG4483	Protein conserved in bacteria
AK39_RS05225	COG1940	carbohydrate kinase activity
AK39_RS05235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_RS05260	COG0626	cystathionine gamma-synthase activity
AK39_RS05265	COG0626	cystathionine gamma-synthase activity
AK39_RS05275	COG0646	methionine synthase
AK39_RS05275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AK39_RS05280	COG1410	methionine synthase
AK39_RS05280	COG0646	methionine synthase
AK39_RS05285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AK39_RS05335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AK39_RS05340	COG1459	type II secretion system
AK39_RS05350	COG4970	Tfp pilus assembly protein FimT
AK39_RS05405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK39_RS05435	COG1725	Transcriptional regulator
AK39_RS05440	COG1131	(ABC) transporter
AK39_RS05480	COG2076	Multidrug Resistance protein
AK39_RS05485	COG2076	Multidrug Resistance protein
AK39_RS05495	COG1609	Transcriptional regulator
AK39_RS05500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_RS05505	COG0095	Lipoate-protein ligase
AK39_RS05525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AK39_RS05535	COG3872	metal-dependent enzyme
AK39_RS05550	COG0006	proline dipeptidase activity
AK39_RS05575	COG3854	ATPases associated with a variety of cellular activities
AK39_RS05620	COG0511	ligase activity, forming carbon-carbon bonds
AK39_RS05625	COG0439	Biotin carboxylase
AK39_RS05630	COG1302	Protein conserved in bacteria
AK39_RS05655	COG0142	geranyltranstransferase activity
AK39_RS05665	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AK39_RS05675	COG0497	DNA recombination
AK39_RS05680	COG0750	zinc metalloprotease
AK39_RS05685	COG0745	RESPONSE REGULATOR receiver
AK39_RS05695	COG3093	addiction module antidote protein HigA
AK39_RS05700	COG0584	glycerophosphoryl diester phosphodiesterase
AK39_RS05710	COG3829	transcription factor binding
AK39_RS05710	COG3290	protein histidine kinase activity
AK39_RS05720	COG0280	phosphate acetyltransferase
AK39_RS05735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AK39_RS05740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK39_RS05745	COG0022	dehydrogenase e1 component
AK39_RS05750	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK39_RS05760	COG0772	Belongs to the SEDS family
AK39_RS05785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK39_RS05790	COG0765	amino acid transport
AK39_RS05795	COG1126	abc transporter atp-binding protein
AK39_RS05800	COG4129	membrane
AK39_RS05805	COG1376	ErfK ybiS ycfS ynhG family protein
AK39_RS05820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_RS05825	COG2195	Cleaves the N-terminal amino acid of tripeptides
AK39_RS05835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK39_RS05855	COG1760	l-serine dehydratase
AK39_RS05860	COG1760	l-serine dehydratase
AK39_RS05865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK39_RS05875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_RS05880	COG0300	oxidoreductase activity
AK39_RS05895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AK39_RS05905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AK39_RS05925	COG1522	sequence-specific DNA binding
AK39_RS05935	COG0737	Belongs to the 5'-nucleotidase family
AK39_RS05940	COG1757	Na H antiporter
AK39_RS05950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK39_RS05965	COG2226	methyltransferase
AK39_RS05965	COG1073	alpha beta
AK39_RS05970	COG4106	trans-aconitate 2-methyltransferase activity
AK39_RS05995	COG0307	riboflavin synthase, alpha
AK39_RS06000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AK39_RS06000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AK39_RS06015	COG1073	alpha beta
AK39_RS06020	COG0456	acetyltransferase
AK39_RS06025	COG1609	Transcriptional regulator
AK39_RS06030	COG2056	Na+-H+ antiporter family
AK39_RS06035	COG0596	Alpha beta hydrolase
AK39_RS06045	COG1525	nuclease
AK39_RS06045	COG4085	toxin activity
AK39_RS06045	COG0737	Belongs to the 5'-nucleotidase family
AK39_RS06055	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK39_RS06055	COG0456	acetyltransferase
AK39_RS06060	COG0656	L-ascorbic acid biosynthetic process
AK39_RS06065	COG0667	Aldo Keto reductase
AK39_RS06085	COG1300	Membrane
AK39_RS06090	COG0735	belongs to the Fur family
AK39_RS06100	COG4974	Belongs to the 'phage' integrase family
AK39_RS06125	COG0598	Magnesium transport protein CorA
AK39_RS06140	COG1846	Transcriptional regulator
AK39_RS06160	COG1131	(ABC) transporter
AK39_RS06165	COG1725	Transcriptional regulator
AK39_RS06170	COG1686	Belongs to the peptidase S11 family
AK39_RS06190	COG0733	neurotransmitter:sodium symporter activity
AK39_RS06215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_RS06230	COG0697	spore germination
AK39_RS06235	COG0561	phosphatase activity
AK39_RS06240	COG4086	secreted protein
AK39_RS06245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AK39_RS06255	COG0456	acetyltransferase
AK39_RS06260	COG1547	Domain of unknown function (DUF309)
AK39_RS06290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AK39_RS06300	COG2188	Transcriptional regulator
AK39_RS06310	COG3711	transcriptional antiterminator
AK39_RS06315	COG1263	PTS System
AK39_RS06315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_RS06315	COG2190	(PTS) system
AK39_RS06340	COG0778	Nitroreductase
AK39_RS06345	COG2199	diguanylate cyclase activity
AK39_RS06365	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AK39_RS06385	COG0436	Aminotransferase
AK39_RS06390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AK39_RS06400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AK39_RS06410	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS06415	COG1695	Transcriptional regulator
AK39_RS06455	COG0183	Belongs to the thiolase family
AK39_RS06495	COG3842	ATPase activity
AK39_RS06500	COG0366	Alpha amylase catalytic
AK39_RS06510	COG2182	Extracellular solute-binding protein
AK39_RS06515	COG1175	transmembrane transport
AK39_RS06520	COG3833	ABC-type maltose transport systems, permease component
AK39_RS06525	COG1609	Transcriptional regulator
AK39_RS06530	COG0436	Aminotransferase
AK39_RS06540	COG2205	protein histidine kinase activity
AK39_RS06550	COG3209	COG3209 Rhs family protein
AK39_RS06575	COG2814	Major facilitator Superfamily
AK39_RS06615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AK39_RS06625	COG1408	metallophosphoesterase
AK39_RS06630	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS06635	COG2200	EAL domain
AK39_RS06650	COG4703	Protein of unknown function (DUF1797)
AK39_RS06660	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AK39_RS06670	COG0517	IMP dehydrogenase activity
AK39_RS06675	COG0583	DNA-binding transcription factor activity
AK39_RS06695	COG0569	domain protein
AK39_RS06700	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK39_RS06710	COG0561	phosphatase activity
AK39_RS06715	COG0242	peptide deformylase activity
AK39_RS06725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK39_RS06730	COG0022	dehydrogenase e1 component
AK39_RS06735	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK39_RS06780	COG1982	Orn Lys Arg decarboxylase major
AK39_RS06800	COG0483	inositol monophosphate 1-phosphatase activity
AK39_RS06810	COG1217	gtp-binding protein TYPA
AK39_RS06825	COG4896	Protein conserved in bacteria
AK39_RS06835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AK39_RS06840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AK39_RS06850	COG0772	Belongs to the SEDS family
AK39_RS06855	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AK39_RS06890	COG3336	cytochrome c oxidase
AK39_RS06905	COG2340	Cysteine-rich secretory protein family
AK39_RS06920	COG0406	alpha-ribazole phosphatase activity
AK39_RS06925	COG3679	Belongs to the UPF0342 family
AK39_RS06940	COG0742	ribosomal rna small subunit methyltransferase
AK39_RS06950	COG3314	Sporulation integral membrane protein YlbJ
AK39_RS06955	COG1752	Esterase of the alpha-beta hydrolase superfamily
AK39_RS06960	COG3480	Lon protease (S16) C-terminal proteolytic domain
AK39_RS06970	COG0582	viral genome integration into host DNA
AK39_RS06985	COG1396	sequence-specific DNA binding
AK39_RS06995	COG1396	sequence-specific DNA binding
AK39_RS07025	COG1484	DNA-dependent DNA replication
AK39_RS07050	COG1191	sigma factor activity
AK39_RS07060	COG0756	dUTP diphosphatase activity
AK39_RS07130	COG0582	viral genome integration into host DNA
AK39_RS07155	COG4626	Terminase
AK39_RS07155	COG1802	Transcriptional regulator
AK39_RS07250	COG4824	toxin secretion phage lysis holin
AK39_RS07300	COG1399	metal-binding, possibly nucleic acid-binding protein
AK39_RS07305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AK39_RS07320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AK39_RS07335	COG4839	cell division protein FtsL
AK39_RS07340	COG0768	penicillin binding
AK39_RS07345	COG0768	penicillin binding
AK39_RS07350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AK39_RS07365	COG0772	Belongs to the SEDS family
AK39_RS07375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AK39_RS07380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AK39_RS07385	COG0849	cell division
AK39_RS07390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AK39_RS07400	COG1191	sigma factor activity
AK39_RS07405	COG1191	sigma factor activity
AK39_RS07410	COG1873	PFAM PRC-barrel domain
AK39_RS07415	COG1496	oxidoreductase activity
AK39_RS07420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AK39_RS07430	COG0762	integral membrane protein
AK39_RS07435	COG2302	S4 RNA-binding domain
AK39_RS07440	COG3599	regulation of cell shape
AK39_RS07460	COG0564	pseudouridine synthase activity
AK39_RS07525	COG3069	C4-dicarboxylate transmembrane transporter activity
AK39_RS07540	COG0006	proline dipeptidase activity
AK39_RS07550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AK39_RS07555	COG1561	YicC-like family, N-terminal region
AK39_RS07575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AK39_RS07580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AK39_RS07585	COG0242	peptide deformylase activity
AK39_RS07595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AK39_RS07595	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AK39_RS07605	COG0631	protein serine/threonine phosphatase activity
AK39_RS07610	COG0515	serine threonine protein kinase
AK39_RS07610	COG2815	serine threonine protein kinase
AK39_RS07615	COG1162	GTPase activity
AK39_RS07620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AK39_RS07625	COG1564	THIamine pyrophosphokinase
AK39_RS07640	COG1302	Protein conserved in bacteria
AK39_RS07645	COG1461	Dihydroxyacetone kinase
AK39_RS07650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AK39_RS07665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AK39_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS07675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AK39_RS07685	COG1196	nuclear chromosome segregation
AK39_RS07690	COG0552	protein localization to endoplasmic reticulum
AK39_RS07700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AK39_RS07710	COG1837	Belongs to the UPF0109 family
AK39_RS07750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AK39_RS07760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AK39_RS07770	COG4974	Belongs to the 'phage' integrase family
AK39_RS07800	COG0528	UMP kinase activity
AK39_RS07810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AK39_RS07815	COG4589	Belongs to the CDS family
AK39_RS07825	COG0750	zinc metalloprotease
AK39_RS07845	COG0195	Participates in both transcription termination and antitermination
AK39_RS07850	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AK39_RS07855	COG1358	cellular component organization or biogenesis
AK39_RS07865	COG1550	Protein conserved in bacteria
AK39_RS07875	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AK39_RS07880	COG0196	riboflavin kinase activity
AK39_RS07895	COG0726	polysaccharide deacetylase
AK39_RS07900	COG0612	Peptidase, M16
AK39_RS07905	COG1873	PFAM PRC-barrel domain
AK39_RS07910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AK39_RS07915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AK39_RS07920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AK39_RS07925	COG0527	aspartate kinase activity
AK39_RS07940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK39_RS07945	COG0740	serine-type endopeptidase activity
AK39_RS07955	COG1674	ftsk spoiiie
AK39_RS07960	COG2188	Transcriptional regulator
AK39_RS07965	COG1744	ABC transporter substrate-binding protein PnrA-like
AK39_RS07970	COG3845	ABC transporter
AK39_RS07975	COG4603	Belongs to the binding-protein-dependent transport system permease family
AK39_RS07980	COG4603	Belongs to the binding-protein-dependent transport system permease family
AK39_RS07990	COG0612	Peptidase, M16
AK39_RS07995	COG0612	Peptidase, M16
AK39_RS08000	COG0300	oxidoreductase activity
AK39_RS08015	COG1426	Protein conserved in bacteria
AK39_RS08020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AK39_RS08045	COG1692	metallophosphoesterase
AK39_RS08050	COG2359	stage V sporulation protein S
AK39_RS08060	COG0674	pyruvate-flavodoxin oxidoreductase activity
AK39_RS08060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AK39_RS08065	COG1013	pyruvate-flavodoxin oxidoreductase activity
AK39_RS08070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AK39_RS08075	COG4550	Control of competence regulator ComK, YlbF/YmcA
AK39_RS08095	COG1131	(ABC) transporter
AK39_RS08120	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AK39_RS08130	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK39_RS08135	COG1368	sulfuric ester hydrolase activity
AK39_RS08140	COG0562	UDP-galactopyranose mutase
AK39_RS08145	COG3773	Cell wall hydrolase
AK39_RS08150	COG1404	Belongs to the peptidase S8 family
AK39_RS08165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AK39_RS08170	COG0596	Alpha beta hydrolase
AK39_RS08170	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK39_RS08175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_RS08180	COG1380	Effector of murein hydrolase LrgA
AK39_RS08185	COG1346	cytolysis
AK39_RS08205	COG3300	MHYT domain
AK39_RS08205	COG5001	Diguanylate cyclase
AK39_RS08210	COG0346	lactoylglutathione lyase activity
AK39_RS08215	COG2267	carboxylic ester hydrolase activity
AK39_RS08230	COG2364	Membrane
AK39_RS08240	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AK39_RS08245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AK39_RS08250	COG2169	Transcriptional regulator
AK39_RS08255	COG0708	Exodeoxyribonuclease III
AK39_RS08265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_RS08270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_RS08275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_RS08280	COG1120	ATPase activity
AK39_RS08285	COG2819	hydrolase of the alpha beta superfamily
AK39_RS08295	COG1937	Protein conserved in bacteria
AK39_RS08300	COG2608	mercury ion transmembrane transporter activity
AK39_RS08305	COG2217	Heavy metal translocating P-type atpase
AK39_RS08315	COG2116	formate transmembrane transporter activity
AK39_RS08320	COG1408	metallophosphoesterase
AK39_RS08330	COG1113	amino acid transport
AK39_RS08345	COG2322	membrane
AK39_RS08355	COG1349	DNA-binding transcription factor activity
AK39_RS08360	COG1105	Belongs to the carbohydrate kinase PfkB family
AK39_RS08365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AK39_RS08365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK39_RS08365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AK39_RS08370	COG3584	3D domain protein
AK39_RS08370	COG1388	LysM domain
AK39_RS08400	COG0464	growth
AK39_RS08405	COG2860	membrane
AK39_RS08415	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AK39_RS08420	COG0789	Transcriptional regulator
AK39_RS08425	COG0174	glutamine synthetase
AK39_RS08450	COG1396	sequence-specific DNA binding
AK39_RS08530	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AK39_RS08575	COG1595	DNA-templated transcription, initiation
AK39_RS08735	COG4824	toxin secretion phage lysis holin
AK39_RS08740	COG1388	LysM domain
AK39_RS08740	COG3409	Peptidoglycan-binding domain 1 protein
AK39_RS08740	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK39_RS08775	COG1695	Transcriptional regulator
AK39_RS08795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AK39_RS08805	COG0737	Belongs to the 5'-nucleotidase family
AK39_RS08820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AK39_RS08825	COG3639	organic phosphonate transmembrane transporter activity
AK39_RS08860	COG1132	(ABC) transporter
AK39_RS08865	COG1132	(ABC) transporter
AK39_RS08880	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK39_RS08880	COG3409	Peptidoglycan-binding domain 1 protein
AK39_RS08890	COG0730	response to heat
AK39_RS08905	COG1346	cytolysis
AK39_RS08910	COG1380	Effector of murein hydrolase LrgA
AK39_RS08915	COG0583	DNA-binding transcription factor activity
AK39_RS08925	COG0785	Cytochrome C biogenesis protein
AK39_RS08930	COG4846	Membrane protein involved in cytochrome C biogenesis
AK39_RS08985	COG2226	methyltransferase
AK39_RS09010	COG0010	Belongs to the arginase family
AK39_RS09015	COG1329	Transcriptional regulator
AK39_RS09020	COG1902	pentaerythritol trinitrate reductase activity
AK39_RS09025	COG0069	glutamate synthase activity
AK39_RS09030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK39_RS09035	COG0346	lactoylglutathione lyase activity
AK39_RS09040	COG0400	carboxylic ester hydrolase activity
AK39_RS09045	COG5002	protein histidine kinase activity
AK39_RS09055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_RS09100	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_RS09105	COG1268	BioY protein
AK39_RS09110	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_RS09115	COG0183	Belongs to the thiolase family
AK39_RS09130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AK39_RS09140	COG2211	Major facilitator Superfamily
AK39_RS09170	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AK39_RS09175	COG2274	protein secretion by the type I secretion system
AK39_RS09185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK39_RS09215	COG0824	Thioesterase
AK39_RS09220	COG4841	protein insertion into membrane
AK39_RS09225	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AK39_RS09240	COG0745	RESPONSE REGULATOR receiver
AK39_RS09245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK39_RS09250	COG1832	CoA-binding protein
AK39_RS09260	COG0187	DNA topoisomerase II activity
AK39_RS09265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AK39_RS09270	COG0673	inositol 2-dehydrogenase activity
AK39_RS09280	COG1131	(ABC) transporter
AK39_RS09305	COG1595	DNA-templated transcription, initiation
AK39_RS09315	COG1316	TRANSCRIPTIONal
AK39_RS09320	COG1301	dicarboxylic acid transport
AK39_RS09325	COG4166	transmembrane transport
AK39_RS09330	COG4166	transmembrane transport
AK39_RS09335	COG4166	transmembrane transport
AK39_RS09340	COG2226	methyltransferase
AK39_RS09380	COG0697	spore germination
AK39_RS09390	COG3383	formate dehydrogenase (NAD+) activity
AK39_RS09395	COG2427	Protein of unknown function (DUF1641)
AK39_RS09400	COG5609	conserved protein (DUF2294)
AK39_RS09405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AK39_RS09415	COG2116	formate transmembrane transporter activity
AK39_RS09420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK39_RS09425	COG0303	'Molybdopterin
AK39_RS09430	COG0314	molybdopterin synthase activity
AK39_RS09440	COG0489	protein tyrosine kinase activity
AK39_RS09455	COG3326	Membrane
AK39_RS09460	COG2962	Rard protein
AK39_RS09465	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AK39_RS09470	COG1657	PFAM Prenyltransferase squalene oxidase
AK39_RS09480	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS09485	COG1012	belongs to the aldehyde dehydrogenase family
AK39_RS09495	COG4145	pantothenate transmembrane transporter activity
AK39_RS09510	COG0165	Argininosuccinate lyase
AK39_RS09520	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS09550	COG0716	FMN binding
AK39_RS09590	COG2720	vancomycin resistance protein
AK39_RS09595	COG2514	catechol 2,3-dioxygenase activity
AK39_RS09605	COG1285	pathogenesis
AK39_RS09615	COG1024	Enoyl-CoA hydratase
AK39_RS09620	COG1216	Glycosyl transferase, family 2
AK39_RS09650	COG0277	FAD linked oxidase domain protein
AK39_RS09655	COG0385	Bile acid
AK39_RS09665	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK39_RS09670	COG2808	Putative FMN-binding domain
AK39_RS09690	COG0604	alcohol dehydrogenase
AK39_RS09695	COG0640	Transcriptional regulator
AK39_RS09720	COG0584	glycerophosphoryl diester phosphodiesterase
AK39_RS09750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK39_RS09755	COG1164	Oligoendopeptidase f
AK39_RS09760	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AK39_RS09775	COG1193	negative regulation of DNA recombination
AK39_RS09795	COG0583	DNA-binding transcription factor activity
AK39_RS09825	COG0384	phenazine biosynthesis protein PhzF
AK39_RS09830	COG3739	integral membrane protein
AK39_RS09835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_RS09840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_RS09850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_RS09870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK39_RS09875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AK39_RS09910	COG2814	Major facilitator Superfamily
AK39_RS09915	COG1113	amino acid transport
AK39_RS09920	COG0604	alcohol dehydrogenase
AK39_RS09955	COG2072	flavoprotein involved in K transport
AK39_RS09990	COG3409	Peptidoglycan-binding domain 1 protein
AK39_RS09990	COG3757	hydrolase, family 25
AK39_RS09995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_RS10005	COG1151	hydroxylamine reductase activity
AK39_RS10030	COG3152	Membrane
AK39_RS10050	COG1309	transcriptional regulator
AK39_RS10065	COG1191	sigma factor activity
AK39_RS10100	COG1733	regulation of RNA biosynthetic process
AK39_RS10110	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_RS10120	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS10130	COG0384	phenazine biosynthesis protein PhzF
AK39_RS10150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_RS10165	COG1733	regulation of RNA biosynthetic process
AK39_RS10170	COG1733	regulation of RNA biosynthetic process
AK39_RS10175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AK39_RS10185	COG2188	Transcriptional regulator
AK39_RS10190	COG1733	regulation of RNA biosynthetic process
AK39_RS10200	COG1393	Belongs to the ArsC family
AK39_RS10225	COG0814	amino acid
AK39_RS10230	COG0346	lactoylglutathione lyase activity
AK39_RS10245	COG2814	Major facilitator Superfamily
AK39_RS10250	COG0656	L-ascorbic acid biosynthetic process
AK39_RS10275	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS10285	COG0604	alcohol dehydrogenase
AK39_RS10285	COG3321	synthase
AK39_RS10295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AK39_RS10300	COG0604	alcohol dehydrogenase
AK39_RS10305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AK39_RS10310	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AK39_RS10325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AK39_RS10335	COG1070	Carbohydrate kinase
AK39_RS10340	COG2706	6-phosphogluconolactonase activity
AK39_RS10345	COG3813	Protein conserved in bacteria
AK39_RS10350	COG1357	PFAM Pentapeptide repeats (8 copies)
AK39_RS10355	COG0697	spore germination
AK39_RS10360	COG0789	Transcriptional regulator
AK39_RS10365	COG1253	flavin adenine dinucleotide binding
AK39_RS10395	COG0477	Major facilitator Superfamily
AK39_RS10405	COG2226	methyltransferase
AK39_RS10425	COG0628	permease
AK39_RS10430	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AK39_RS10440	COG1136	(ABC) transporter
AK39_RS10440	COG0577	efflux transmembrane transporter activity
AK39_RS10455	COG0110	maltose O-acetyltransferase activity
AK39_RS10460	COG0738	Major facilitator superfamily
AK39_RS10465	COG1940	carbohydrate kinase activity
AK39_RS10470	COG0346	lactoylglutathione lyase activity
AK39_RS10495	COG2365	Tyrosine phosphatase family
AK39_RS10505	COG1011	Hydrolase
AK39_RS10530	COG1131	(ABC) transporter
AK39_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS10560	COG0778	Nitroreductase
AK39_RS10565	COG1733	regulation of RNA biosynthetic process
AK39_RS10580	COG0124	histidyl-tRNA synthetase
AK39_RS10585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AK39_RS10590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AK39_RS10595	COG3620	sequence-specific DNA binding
AK39_RS10610	COG2356	endonuclease I
AK39_RS10615	COG1288	antiporter activity
AK39_RS10620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AK39_RS10635	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AK39_RS10640	COG1122	ATPase activity
AK39_RS10670	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK39_RS10680	COG2031	fatty acid transporter
AK39_RS10695	COG1309	transcriptional regulator
AK39_RS10700	COG2076	Multidrug Resistance protein
AK39_RS10720	COG1131	(ABC) transporter
AK39_RS10725	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK39_RS10740	COG2814	Major facilitator Superfamily
AK39_RS10745	COG1846	Transcriptional regulator
AK39_RS10755	COG0477	Major facilitator Superfamily
AK39_RS10810	COG2207	Transcriptional regulator
AK39_RS10810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_RS10820	COG0662	Cupin 2, conserved barrel domain protein
AK39_RS10835	COG1595	DNA-templated transcription, initiation
AK39_RS10855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AK39_RS10870	COG0531	amino acid
AK39_RS10875	COG1522	sequence-specific DNA binding
AK39_RS10880	COG1335	isochorismatase
AK39_RS10890	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AK39_RS10895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AK39_RS10905	COG1760	l-serine dehydratase
AK39_RS10910	COG1760	l-serine dehydratase
AK39_RS10915	COG0814	amino acid
AK39_RS10930	COG1309	transcriptional regulator
AK39_RS10935	COG2814	Major facilitator Superfamily
AK39_RS10950	COG0534	Mate efflux family protein
AK39_RS10980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK39_RS11000	COG0457	Tetratricopeptide repeat
AK39_RS11005	COG1609	Transcriptional regulator
AK39_RS11015	COG0561	phosphatase activity
AK39_RS11020	COG0673	inositol 2-dehydrogenase activity
AK39_RS11025	COG0738	Major facilitator superfamily
AK39_RS11050	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK39_RS11060	COG0583	DNA-binding transcription factor activity
AK39_RS11070	COG1139	Iron-sulfur cluster binding protein
AK39_RS11075	COG1556	Lactate utilization protein
AK39_RS11080	COG2271	Major facilitator Superfamily
AK39_RS11085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_RS11090	COG2808	Putative FMN-binding domain
AK39_RS11100	COG1846	Transcriptional regulator
AK39_RS11105	COG2364	Membrane
AK39_RS11115	COG5002	protein histidine kinase activity
AK39_RS11115	COG3850	Histidine kinase
AK39_RS11135	COG0577	efflux transmembrane transporter activity
AK39_RS11140	COG1136	(ABC) transporter
AK39_RS11155	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AK39_RS11160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_RS11170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK39_RS11175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_RS11190	COG1476	TRANSCRIPTIONal
AK39_RS11215	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AK39_RS11245	COG3850	Histidine kinase
AK39_RS11245	COG5002	protein histidine kinase activity
AK39_RS11250	COG0745	RESPONSE REGULATOR receiver
AK39_RS11275	COG2814	Major facilitator Superfamily
AK39_RS11320	COG2169	Transcriptional regulator
AK39_RS11345	COG0346	lactoylglutathione lyase activity
AK39_RS11360	COG1522	sequence-specific DNA binding
AK39_RS11375	COG0443	Heat shock 70 kDa protein
AK39_RS11390	COG0640	Transcriptional regulator
AK39_RS11395	COG0346	lactoylglutathione lyase activity
AK39_RS11400	COG0798	PFAM Bile acid sodium symporter
AK39_RS11430	COG1121	(ABC) transporter
AK39_RS11435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AK39_RS11440	COG0803	Belongs to the bacterial solute-binding protein 9 family
AK39_RS11445	COG2267	carboxylic ester hydrolase activity
AK39_RS11450	COG1575	Belongs to the MenA family. Type 1 subfamily
AK39_RS11460	COG5609	conserved protein (DUF2294)
AK39_RS11465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AK39_RS11475	COG0288	reversible hydration of carbon dioxide
AK39_RS11480	COG0415	Belongs to the DNA photolyase family
AK39_RS11525	COG0583	DNA-binding transcription factor activity
AK39_RS11550	COG1335	isochorismatase
AK39_RS11555	COG2267	carboxylic ester hydrolase activity
AK39_RS11560	COG0753	catalase activity
AK39_RS11565	COG0737	Belongs to the 5'-nucleotidase family
AK39_RS11590	COG1115	amino acid carrier protein
AK39_RS11595	COG2066	Belongs to the glutaminase family
AK39_RS11605	COG0784	Response regulator, receiver
AK39_RS11610	COG0697	spore germination
AK39_RS11615	COG0531	amino acid
AK39_RS11635	COG0281	malic enzyme
AK39_RS11645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK39_RS11650	COG1114	Component of the transport system for branched-chain amino acids
AK39_RS11655	COG0531	amino acid
AK39_RS11660	COG0322	excinuclease ABC activity
AK39_RS11670	COG1396	sequence-specific DNA binding
AK39_RS11675	COG0252	asparaginase activity
AK39_RS11680	COG1027	Aspartate ammonia-lyase
AK39_RS11695	COG1063	alcohol dehydrogenase
AK39_RS11730	COG1280	lysine exporter protein (LysE YggA)
AK39_RS11735	COG3403	YqcI/YcgG family
AK39_RS11740	COG5577	PFAM Coat F domain
AK39_RS11755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_RS11760	COG3848	Pyruvate phosphate dikinase
AK39_RS11760	COG0574	Belongs to the PEP-utilizing enzyme family
AK39_RS11775	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AK39_RS11790	COG3314	Sporulation integral membrane protein YlbJ
AK39_RS11810	COG1960	acyl-CoA dehydrogenase activity
AK39_RS11820	COG0640	Transcriptional regulator
AK39_RS11825	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK39_RS11840	COG1414	Transcriptional regulator
AK39_RS11845	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AK39_RS11880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AK39_RS11890	COG0768	penicillin binding
AK39_RS11930	COG4335	DNA alkylation repair
AK39_RS11940	COG0833	amino acid
AK39_RS11950	COG0730	response to heat
AK39_RS11980	COG0596	Alpha beta hydrolase
AK39_RS11985	COG0745	RESPONSE REGULATOR receiver
AK39_RS11990	COG0642	Histidine kinase
AK39_RS12010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_RS12030	COG0456	acetyltransferase
AK39_RS12035	COG2207	Transcriptional regulator
AK39_RS12060	COG1136	(ABC) transporter
AK39_RS12060	COG0577	efflux transmembrane transporter activity
AK39_RS12070	COG1725	Transcriptional regulator
AK39_RS12105	COG1846	Transcriptional regulator
AK39_RS12110	COG0778	Nitroreductase
AK39_RS12120	COG0714	Associated with various cellular activities
AK39_RS12145	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AK39_RS12155	COG0753	catalase activity
AK39_RS12160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AK39_RS12170	COG0463	Glycosyl transferase, family 2
AK39_RS12195	COG0463	Glycosyl transferase, family 2
AK39_RS12220	COG0714	Associated with various cellular activities
AK39_RS12240	COG0346	lactoylglutathione lyase activity
AK39_RS12245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_RS12255	COG3279	Response regulator of the LytR AlgR family
AK39_RS12265	COG4377	Putative membrane peptidase family (DUF2324)
AK39_RS12280	COG3655	Transcriptional regulator
AK39_RS12290	COG1785	Belongs to the alkaline phosphatase family
AK39_RS12295	COG3239	Fatty acid desaturase
AK39_RS12300	COG1690	Belongs to the RtcB family
AK39_RS12305	COG0833	amino acid
AK39_RS12310	COG1414	Transcriptional regulator
AK39_RS12315	COG4187	Peptidase family M20/M25/M40
AK39_RS12320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK39_RS12325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AK39_RS12335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_RS12355	COG2329	Antibiotic biosynthesis monooxygenase
AK39_RS12390	COG2390	Transcriptional regulator
AK39_RS12400	COG1172	Belongs to the binding-protein-dependent transport system permease family
AK39_RS12410	COG1879	ABC-type sugar transport system periplasmic component
AK39_RS12435	COG1595	DNA-templated transcription, initiation
AK39_RS12445	COG3584	3D domain protein
AK39_RS12445	COG1388	LysM domain
AK39_RS12480	COG1605	Chorismate mutase
AK39_RS12480	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AK39_RS12485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AK39_RS12490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AK39_RS12495	COG0287	Prephenate dehydrogenase
AK39_RS12510	COG1309	transcriptional regulator
AK39_RS12515	COG2409	Drug exporters of the RND superfamily
AK39_RS12515	COG1033	growth of symbiont in host cell
AK39_RS12520	COG1033	growth of symbiont in host cell
AK39_RS12520	COG2409	Drug exporters of the RND superfamily
AK39_RS12525	COG1033	growth of symbiont in host cell
AK39_RS12525	COG2409	Drug exporters of the RND superfamily
AK39_RS12535	COG0488	(ABC) transporter
AK39_RS12540	COG1368	sulfuric ester hydrolase activity
AK39_RS12545	COG0861	Integral membrane protein TerC family
AK39_RS12565	COG4912	Dna alkylation repair
AK39_RS12585	COG2318	DinB family
AK39_RS12590	COG0697	spore germination
AK39_RS12615	COG2746	aminoglycoside 3-N-acetyltransferase activity
AK39_RS12635	COG2816	NAD+ diphosphatase activity
AK39_RS12655	COG1116	anion transmembrane transporter activity
AK39_RS12660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK39_RS12665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK39_RS12670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AK39_RS12685	COG0628	permease
AK39_RS12735	COG1131	(ABC) transporter
AK39_RS12760	COG5146	pantothenate kinase activity
AK39_RS12765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AK39_RS12770	COG0436	Aminotransferase
AK39_RS12805	COG2226	methyltransferase
AK39_RS12820	COG2261	transglycosylase associated protein
AK39_RS12840	COG0477	Major facilitator Superfamily
AK39_RS12840	COG2814	Major facilitator Superfamily
AK39_RS12845	COG4533	DNA binding
AK39_RS12850	COG0789	Transcriptional regulator
AK39_RS12855	COG1664	Polymer-forming cytoskeletal
AK39_RS12865	COG2814	Major facilitator Superfamily
AK39_RS12885	COG1307	EDD domain protein, DegV family
AK39_RS12925	COG0745	RESPONSE REGULATOR receiver
AK39_RS12930	COG5002	protein histidine kinase activity
AK39_RS12935	COG2936	dipeptidyl-peptidase activity
AK39_RS12975	COG4948	Mandelate Racemase Muconate Lactonizing
AK39_RS12985	COG4166	transmembrane transport
AK39_RS12990	COG0519	Catalyzes the synthesis of GMP from XMP
AK39_RS12995	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AK39_RS13010	COG0586	Pfam SNARE associated Golgi protein
AK39_RS13050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK39_RS13055	COG3938	Belongs to the proline racemase family
AK39_RS13065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AK39_RS13070	COG1012	belongs to the aldehyde dehydrogenase family
AK39_RS13075	COG1115	amino acid carrier protein
AK39_RS13080	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AK39_RS13090	COG3397	chitin binding
AK39_RS13115	COG4637	Psort location Cytoplasmic, score
AK39_RS13145	COG0514	ATP-dependent DNA helicase (RecQ)
AK39_RS13150	COG2105	PFAM AIG2 family protein
AK39_RS13165	COG3973	AAA domain
AK39_RS13215	COG0658	competence protein
AK39_RS13215	COG2333	competence protein COMEC
AK39_RS13245	COG2205	protein histidine kinase activity
AK39_RS13260	COG3397	chitin binding
AK39_RS13265	COG2153	protein acetylation
AK39_RS13270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AK39_RS13295	COG0517	IMP dehydrogenase activity
AK39_RS13295	COG4175	Glycine betaine
AK39_RS13300	COG4176	ABC-type proline glycine betaine transport system permease component
AK39_RS13335	COG0456	acetyltransferase
AK39_RS13335	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK39_RS13340	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS13350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK39_RS13355	COG0022	dehydrogenase e1 component
AK39_RS13360	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK39_RS13365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AK39_RS13380	COG1959	2 iron, 2 sulfur cluster binding
AK39_RS13400	COG1349	DNA-binding transcription factor activity
AK39_RS13420	COG3284	Transcriptional regulator
AK39_RS13450	COG1309	transcriptional regulator
AK39_RS13455	COG3844	kynureninase activity
AK39_RS13460	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AK39_RS13465	COG3483	tryptophan 2,3-dioxygenase activity
AK39_RS13485	COG2959	enzyme of heme biosynthesis
AK39_RS13500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_RS13505	COG4129	membrane
AK39_RS13535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_RS13540	COG0697	spore germination
AK39_RS13550	COG0201	protein transport
AK39_RS13570	COG3227	Zinc metalloprotease (Elastase)
AK39_RS13590	COG0076	glutamate decarboxylase activity
AK39_RS13610	COG1011	Hydrolase
AK39_RS13635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK39_RS13675	COG0322	excinuclease ABC activity
AK39_RS13690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AK39_RS13715	COG4667	esterase of the alpha-beta hydrolase superfamily
AK39_RS13745	COG3878	Protein conserved in bacteria
AK39_RS13780	COG1051	belongs to the nudix hydrolase family
AK39_RS13785	COG0592	DNA-directed DNA polymerase activity
AK39_RS13790	COG2816	NAD+ diphosphatase activity
AK39_RS13805	COG2223	nitrite transmembrane transporter activity
AK39_RS13815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK39_RS13840	COG0697	spore germination
AK39_RS13860	COG0584	glycerophosphoryl diester phosphodiesterase
AK39_RS13875	COG2814	Major facilitator Superfamily
AK39_RS13905	COG0693	protein deglycase activity
AK39_RS13940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK39_RS13950	COG0768	penicillin binding
AK39_RS13955	COG0604	alcohol dehydrogenase
AK39_RS13960	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK39_RS13970	COG2205	protein histidine kinase activity
AK39_RS13980	COG1122	ATPase activity
AK39_RS13990	COG1794	racemase activity, acting on amino acids and derivatives
AK39_RS13995	COG1819	glycosyl
AK39_RS14000	COG0768	penicillin binding
AK39_RS14005	COG5002	protein histidine kinase activity
AK39_RS14015	COG0561	phosphatase activity
AK39_RS14050	COG2124	cytochrome p450
AK39_RS14125	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AK39_RS14135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_RS14140	COG0460	homoserine dehydrogenase
AK39_RS14165	COG1136	(ABC) transporter
AK39_RS14195	COG0745	RESPONSE REGULATOR receiver
AK39_RS14205	COG3773	Cell wall hydrolase
AK39_RS14220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AK39_RS14225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AK39_RS14240	COG1063	alcohol dehydrogenase
AK39_RS14255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_RS14275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK39_RS14295	COG2814	Major facilitator Superfamily
AK39_RS14320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK39_RS14320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK39_RS14360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AK39_RS14385	COG1686	Belongs to the peptidase S11 family
AK39_RS14390	COG2318	DinB family
AK39_RS14400	COG0572	uridine kinase
AK39_RS14405	COG1247	-acetyltransferase
AK39_RS14415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AK39_RS14420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AK39_RS14425	COG1024	Enoyl-CoA hydratase
AK39_RS14430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AK39_RS14435	COG0511	ligase activity, forming carbon-carbon bonds
AK39_RS14440	COG0439	Biotin carboxylase
AK39_RS14445	COG1960	acyl-CoA dehydrogenase activity
AK39_RS14460	COG1309	transcriptional regulator
AK39_RS14470	COG1131	(ABC) transporter
AK39_RS14485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_RS14490	COG1252	NADH dehydrogenase
AK39_RS14500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_RS14515	COG0488	(ABC) transporter
AK39_RS14520	COG1309	transcriptional regulator
AK39_RS14540	COG1876	peptidase activity
AK39_RS14555	COG1476	TRANSCRIPTIONal
AK39_RS14560	COG0457	Tetratricopeptide repeat
AK39_RS14570	COG0737	Belongs to the 5'-nucleotidase family
AK39_RS14580	COG0737	Belongs to the 5'-nucleotidase family
AK39_RS14595	COG3718	enzyme involved in inositol metabolism
AK39_RS14615	COG1012	belongs to the aldehyde dehydrogenase family
AK39_RS14625	COG0673	inositol 2-dehydrogenase activity
AK39_RS14630	COG2814	Major facilitator Superfamily
AK39_RS14635	COG1609	Transcriptional regulator
AK39_RS14640	COG0671	phosphoesterase, PA-phosphatase related
AK39_RS14645	COG2367	Beta-lactamase
AK39_RS14655	COG0768	penicillin binding
AK39_RS14665	COG1595	DNA-templated transcription, initiation
AK39_RS14680	COG2195	Cleaves the N-terminal amino acid of tripeptides
AK39_RS14720	COG1846	Transcriptional regulator
AK39_RS14725	COG3961	Belongs to the TPP enzyme family
AK39_RS14730	COG2226	methyltransferase
AK39_RS14740	COG0500	methyltransferase
AK39_RS14740	COG3615	Tellurite resistance protein tehB
AK39_RS14745	COG1136	(ABC) transporter
AK39_RS14745	COG0577	efflux transmembrane transporter activity
AK39_RS14760	COG1309	transcriptional regulator
AK39_RS14790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_RS14810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AK39_RS14815	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AK39_RS14820	COG2971	BadF BadG BcrA BcrD
AK39_RS14845	COG1649	PFAM Uncharacterised BCR, COG1649
AK39_RS14870	COG1595	DNA-templated transcription, initiation
AK39_RS14900	COG1396	sequence-specific DNA binding
AK39_RS14920	COG1132	(ABC) transporter
AK39_RS14925	COG1132	(ABC) transporter
AK39_RS14940	COG2258	MOSC domain
AK39_RS14945	COG0583	DNA-binding transcription factor activity
AK39_RS14960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AK39_RS14965	COG0583	DNA-binding transcription factor activity
AK39_RS15010	COG0561	phosphatase activity
AK39_RS15015	COG0010	Belongs to the arginase family
AK39_RS15030	COG1278	Cold shock
AK39_RS15040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_RS15050	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AK39_RS15080	COG1247	-acetyltransferase
AK39_RS15115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_RS15160	COG2226	methyltransferase
AK39_RS15180	COG2814	Major facilitator Superfamily
AK39_RS15185	COG0596	Alpha beta hydrolase
AK39_RS15200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AK39_RS15205	COG1187	pseudouridine synthase activity
AK39_RS15210	COG2329	Antibiotic biosynthesis monooxygenase
AK39_RS15230	COG1115	amino acid carrier protein
AK39_RS15240	COG2318	DinB family
AK39_RS15250	COG0776	regulation of translation
AK39_RS15265	COG2814	Major facilitator Superfamily
AK39_RS15270	COG3251	PFAM MbtH domain protein
AK39_RS15275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AK39_RS15280	COG1535	isochorismatase
AK39_RS15280	COG3433	isochorismatase activity
AK39_RS15285	COG1021	2,3-dihydroxybenzoate-AMP ligase
AK39_RS15290	COG1169	isochorismate synthase
AK39_RS15295	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS15300	COG2223	nitrite transmembrane transporter activity
AK39_RS15330	COG0419	ATPase involved in DNA repair
AK39_RS15335	COG0420	3'-5' exonuclease activity
AK39_RS15350	COG1024	Enoyl-CoA hydratase
AK39_RS15355	COG1280	lysine exporter protein (LysE YggA)
AK39_RS15365	COG2084	Dehydrogenase
AK39_RS15370	COG1960	acyl-CoA dehydrogenase activity
AK39_RS15375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AK39_RS15380	COG2079	MmgE PrpD family protein
AK39_RS15385	COG0372	Belongs to the citrate synthase family
AK39_RS15390	COG4841	protein insertion into membrane
AK39_RS15395	COG2814	Major facilitator Superfamily
AK39_RS15400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK39_RS15400	COG4499	WXG100 protein secretion system (Wss), protein YukC
AK39_RS15440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK39_RS15530	COG1787	Restriction endonuclease
AK39_RS15530	COG1715	Restriction endonuclease
AK39_RS15560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK39_RS15565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AK39_RS15570	COG0671	phosphoesterase, PA-phosphatase related
AK39_RS15575	COG4326	sporulation control protein
AK39_RS15615	COG1509	lysine 2,3-aminomutase activity
AK39_RS15620	COG3829	transcription factor binding
AK39_RS15625	COG0456	acetyltransferase
AK39_RS15630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK39_RS15635	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AK39_RS15640	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AK39_RS15645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK39_RS15660	COG5506	Protein of unknown function (DUF1694)
AK39_RS15665	COG1012	belongs to the aldehyde dehydrogenase family
AK39_RS15670	COG1253	flavin adenine dinucleotide binding
AK39_RS15705	COG1174	glycine betaine transport
AK39_RS15710	COG0517	IMP dehydrogenase activity
AK39_RS15710	COG1125	glycine betaine transport
AK39_RS15740	COG1070	Carbohydrate kinase
AK39_RS15745	COG1070	Carbohydrate kinase
AK39_RS15775	COG1064	alcohol dehydrogenase
AK39_RS15780	COG1737	Transcriptional regulator
AK39_RS15790	COG2197	response regulator
AK39_RS15795	COG2203	Gaf domain
AK39_RS15795	COG4585	Histidine kinase
AK39_RS15800	COG0668	transmembrane transport
AK39_RS15835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK39_RS15840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_RS15860	COG0367	asparagine synthase
AK39_RS15865	COG0071	Belongs to the small heat shock protein (HSP20) family
AK39_RS15870	COG1999	signal sequence binding
AK39_RS15875	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AK39_RS15880	COG1307	EDD domain protein, DegV family
AK39_RS15890	COG0805	protein transport
AK39_RS15900	COG1272	protein, Hemolysin III
AK39_RS15905	COG0204	Acyl-transferase
AK39_RS15910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AK39_RS15915	COG0768	penicillin binding
AK39_RS15930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK39_RS15950	COG0546	phosphoglycolate phosphatase activity
AK39_RS15960	COG4473	ABC transporter
AK39_RS15965	COG1131	(ABC) transporter
AK39_RS15980	COG0456	acetyltransferase
AK39_RS15990	COG1794	racemase activity, acting on amino acids and derivatives
AK39_RS15995	COG1454	alcohol dehydrogenase
AK39_RS16000	COG2610	gluconate transmembrane transporter activity
AK39_RS16025	COG0733	neurotransmitter:sodium symporter activity
AK39_RS16040	COG5002	protein histidine kinase activity
AK39_RS16040	COG3850	Histidine kinase
AK39_RS16045	COG0745	RESPONSE REGULATOR receiver
AK39_RS16050	COG0471	metal ion transport
AK39_RS16055	COG1929	Belongs to the glycerate kinase type-1 family
AK39_RS16150	COG1674	ftsk spoiiie
AK39_RS16170	COG0017	Asparaginyl-tRNA synthetase
AK39_RS16175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AK39_RS16190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AK39_RS16215	COG0018	arginyl-trna synthetase
AK39_RS16220	COG2136	Putative SAM-dependent methyltransferase
AK39_RS16220	COG2521	methyltransferase
AK39_RS16235	COG1413	lyase activity
AK39_RS16240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AK39_RS16255	COG0629	single-stranded DNA binding
AK39_RS16270	COG0488	(ABC) transporter
AK39_RS16275	COG1418	mRNA catabolic process
AK39_RS16290	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK39_RS16305	COG2359	stage V sporulation protein S
AK39_RS16340	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AK39_RS16345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AK39_RS16350	COG2146	nitrite reductase [NAD(P)H] activity
AK39_RS16355	COG1587	Uroporphyrinogen-III synthase
AK39_RS16355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AK39_RS16365	COG1648	precorrin-2 dehydrogenase activity
AK39_RS16380	COG2223	nitrite transmembrane transporter activity
AK39_RS16390	COG0314	molybdopterin synthase activity
AK39_RS16395	COG0303	'Molybdopterin
AK39_RS16400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK39_RS16405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AK39_RS16410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AK39_RS16430	COG2181	nitrate reductase activity
AK39_RS16435	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AK39_RS16440	COG1140	nitrate reductase beta subunit
AK39_RS16445	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AK39_RS16460	COG0714	Associated with various cellular activities
AK39_RS16465	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AK39_RS16470	COG1305	Transglutaminase-like
AK39_RS16475	COG0386	Belongs to the glutathione peroxidase family
AK39_RS16500	COG1595	DNA-templated transcription, initiation
AK39_RS16505	COG0604	alcohol dehydrogenase
AK39_RS16515	COG0346	lactoylglutathione lyase activity
AK39_RS16520	COG1082	Xylose isomerase domain protein TIM barrel
AK39_RS16540	COG2226	methyltransferase
AK39_RS16565	COG3874	Sporulation protein YtfJ
AK39_RS16615	COG0456	acetyltransferase
AK39_RS16640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_RS16645	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_RS16650	COG1819	glycosyl
AK39_RS16665	COG4106	trans-aconitate 2-methyltransferase activity
AK39_RS16670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AK39_RS16680	COG0561	phosphatase activity
AK39_RS16700	COG2211	Major facilitator Superfamily
AK39_RS16705	COG0154	amidase activity
AK39_RS16715	COG1876	peptidase activity
AK39_RS16725	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK39_RS16745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK39_RS16750	COG1114	Component of the transport system for branched-chain amino acids
AK39_RS16765	COG1253	flavin adenine dinucleotide binding
AK39_RS16770	COG2839	Protein conserved in bacteria
AK39_RS16775	COG0702	epimerase
AK39_RS16790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK39_RS16795	COG1607	acyl-coa hydrolase
AK39_RS16800	COG3689	TIGRFAM TIGR03943 family protein
AK39_RS16805	COG0701	Predicted permease
AK39_RS16815	COG2244	polysaccharide biosynthetic process
AK39_RS16820	COG0586	Pfam SNARE associated Golgi protein
AK39_RS16825	COG1051	belongs to the nudix hydrolase family
AK39_RS16830	COG5337	Spore coat protein CotH
AK39_RS16840	COG0406	alpha-ribazole phosphatase activity
AK39_RS16855	COG4166	transmembrane transport
AK39_RS16865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AK39_RS16875	COG0702	epimerase
AK39_RS16885	COG0803	Belongs to the bacterial solute-binding protein 9 family
AK39_RS16885	COG3443	Belongs to the bacterial solute-binding protein 9 family
AK39_RS16950	COG0456	acetyltransferase
AK39_RS16955	COG0523	cobalamin synthesis protein
AK39_RS16960	COG4989	oxidoreductase activity
AK39_RS16970	COG1231	oxidoreductase activity
AK39_RS16980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AK39_RS16995	COG0783	Belongs to the Dps family
AK39_RS17000	COG3949	Membrane
AK39_RS17020	COG0840	transmembrane signaling receptor activity
AK39_RS17045	COG2814	Major facilitator Superfamily
AK39_RS17050	COG0667	Aldo Keto reductase
AK39_RS17055	COG0640	Transcriptional regulator
AK39_RS17060	COG1404	Belongs to the peptidase S8 family
AK39_RS17065	COG2002	toxin-antitoxin pair type II binding
AK39_RS17105	COG1752	Esterase of the alpha-beta hydrolase superfamily
AK39_RS17115	COG1279	arginine transmembrane transporter activity
AK39_RS17130	COG1082	Xylose isomerase domain protein TIM barrel
AK39_RS17140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AK39_RS17160	COG1247	-acetyltransferase
AK39_RS17165	COG1285	pathogenesis
AK39_RS17180	COG5002	protein histidine kinase activity
AK39_RS17185	COG0745	RESPONSE REGULATOR receiver
AK39_RS17195	COG1316	TRANSCRIPTIONal
AK39_RS17220	COG0460	homoserine dehydrogenase
AK39_RS17255	COG0300	oxidoreductase activity
AK39_RS17265	COG5002	protein histidine kinase activity
AK39_RS17270	COG0745	RESPONSE REGULATOR receiver
AK39_RS17275	COG1132	(ABC) transporter
AK39_RS17280	COG1132	(ABC) transporter
AK39_RS17290	COG0791	NLP P60 protein
AK39_RS17290	COG1388	LysM domain
AK39_RS17305	COG1686	Belongs to the peptidase S11 family
AK39_RS17325	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AK39_RS17330	COG4988	ABC transporter
AK39_RS17335	COG1294	oxidase, subunit
AK39_RS17340	COG1271	oxidase subunit
AK39_RS17370	COG0583	DNA-binding transcription factor activity
AK39_RS17390	COG0411	ABC transporter
AK39_RS17400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_RS17405	COG2030	dehydratase
AK39_RS17410	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_RS17425	COG0523	cobalamin synthesis protein
AK39_RS17430	COG1231	oxidoreductase activity
AK39_RS17440	COG0628	permease
AK39_RS17455	COG0778	Nitroreductase
AK39_RS17460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AK39_RS17465	COG1959	2 iron, 2 sulfur cluster binding
AK39_RS17470	COG0583	DNA-binding transcription factor activity
AK39_RS17475	COG0697	spore germination
AK39_RS17485	COG4549	nuclear export factor GLE1
AK39_RS17490	COG1276	copper resistance
AK39_RS17490	COG2372	response to copper ion
AK39_RS17505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AK39_RS17520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AK39_RS17535	COG2132	Multicopper oxidase
AK39_RS17540	COG0006	proline dipeptidase activity
AK39_RS17560	COG4224	UPF0291 protein
AK39_RS17575	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AK39_RS17580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_RS17590	COG2390	Transcriptional regulator
AK39_RS17625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AK39_RS17640	COG1914	H( )-stimulated, divalent metal cation uptake system
AK39_RS17655	COG0745	RESPONSE REGULATOR receiver
AK39_RS17660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK39_RS17665	COG0535	radical SAM domain protein
AK39_RS17690	COG4166	transmembrane transport
AK39_RS17695	COG1073	alpha beta
AK39_RS17715	COG0427	acetyl-CoA hydrolase
AK39_RS17720	COG3279	Response regulator of the LytR AlgR family
AK39_RS17730	COG3384	dioxygenase
AK39_RS17735	COG2814	Major facilitator Superfamily
AK39_RS17760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AK39_RS17770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AK39_RS17775	COG0440	acetolactate synthase activity
AK39_RS17780	COG0028	Belongs to the TPP enzyme family
AK39_RS17785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK39_RS17795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK39_RS17810	COG2084	Dehydrogenase
AK39_RS17825	COG2323	membrane
AK39_RS17830	COG5566	PFAM Mor transcription activator
AK39_RS17840	COG0733	neurotransmitter:sodium symporter activity
AK39_RS17845	COG2244	polysaccharide biosynthetic process
AK39_RS17860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK39_RS17865	COG2223	nitrite transmembrane transporter activity
AK39_RS17870	COG4166	transmembrane transport
AK39_RS17880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AK39_RS17890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_RS17905	COG1966	Carbon starvation protein
AK39_RS17920	COG2814	Major facilitator Superfamily
AK39_RS17930	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK39_RS17935	COG1051	belongs to the nudix hydrolase family
AK39_RS17995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK39_RS18000	COG0784	Response regulator, receiver
AK39_RS18005	COG4191	Histidine kinase
AK39_RS18010	COG0281	malic enzyme
AK39_RS18015	COG1027	Aspartate ammonia-lyase
AK39_RS18025	COG0528	UMP kinase activity
AK39_RS18030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK39_RS18045	COG1131	(ABC) transporter
AK39_RS18080	COG2733	membrane
AK39_RS18115	COG0785	Cytochrome C biogenesis protein
AK39_RS18135	COG3340	Belongs to the peptidase S51 family
AK39_RS18165	COG0114	fumarate hydratase activity
AK39_RS18170	COG1757	Na H antiporter
AK39_RS18175	COG1216	Glycosyl transferase, family 2
AK39_RS18175	COG0438	transferase activity, transferring glycosyl groups
AK39_RS18185	COG0701	Predicted permease
AK39_RS18190	COG0523	cobalamin synthesis protein
AK39_RS18195	COG0697	spore germination
AK39_RS18200	COG1802	Transcriptional regulator
AK39_RS18230	COG0367	asparagine synthase
AK39_RS18260	COG0406	alpha-ribazole phosphatase activity
AK39_RS18270	COG1686	Belongs to the peptidase S11 family
AK39_RS18295	COG1234	tRNA 3'-trailer cleavage
AK39_RS18305	COG0725	ABC transporter, periplasmic molybdate-binding protein
AK39_RS18310	COG3842	ATPase activity
AK39_RS18315	COG0583	DNA-binding transcription factor activity
AK39_RS18340	COG2329	Antibiotic biosynthesis monooxygenase
AK39_RS18360	COG1309	transcriptional regulator
AK39_RS18385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AK39_RS18390	COG4786	Flagellar basal body rod
AK39_RS18400	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AK39_RS18405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AK39_RS18415	COG1987	bacterial-type flagellum assembly
AK39_RS18420	COG1338	Plays a role in the flagellum-specific transport system
AK39_RS18430	COG1776	CheC inhibitor of MCP methylation
AK39_RS18430	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK39_RS18445	COG0741	lytic transglycosylase activity
AK39_RS18450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AK39_RS18475	COG0457	Tetratricopeptide repeat
AK39_RS18475	COG0463	Glycosyl transferase, family 2
AK39_RS18505	COG0463	Glycosyl transferase, family 2
AK39_RS18515	COG0835	chemotaxis
AK39_RS18515	COG0784	Response regulator, receiver
AK39_RS18555	COG1157	protein secretion by the type III secretion system
AK39_RS18565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK39_RS18575	COG1766	The M ring may be actively involved in energy transduction
AK39_RS18585	COG1558	bacterial-type flagellum-dependent cell motility
AK39_RS18590	COG1815	bacterial-type flagellum-dependent cell motility
AK39_RS18615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AK39_RS18620	COG1256	bacterial-type flagellum assembly
AK39_RS18640	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AK39_RS18655	COG1776	CheC inhibitor of MCP methylation
AK39_RS18655	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK39_RS18665	COG2201	protein-glutamate methylesterase activity
AK39_RS18670	COG1360	Flagellar Motor Protein
AK39_RS18675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AK39_RS18685	COG1923	regulation of RNA biosynthetic process
AK39_RS18740	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AK39_RS18745	COG2323	membrane
AK39_RS18760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK39_RS18765	COG0475	glutathione-regulated potassium exporter activity
AK39_RS18775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK39_RS18780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK39_RS18785	COG3162	membrane
AK39_RS18800	COG1280	lysine exporter protein (LysE YggA)
AK39_RS18840	COG0328	RNA-DNA hybrid ribonuclease activity
AK39_RS18860	COG0454	-acetyltransferase
AK39_RS18880	COG1215	transferase activity, transferring glycosyl groups
AK39_RS18895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AK39_RS18920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK39_RS18935	COG0754	glutathionylspermidine amidase activity
AK39_RS18960	COG0456	acetyltransferase
AK39_RS18970	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK39_RS18975	COG2311	Membrane
AK39_RS18980	COG2233	PERMEase
AK39_RS18990	COG0024	Methionine aminopeptidase
AK39_RS18995	COG3173	Aminoglycoside phosphotransferase
AK39_RS19005	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AK39_RS19010	COG1199	ATP-dependent helicase activity
AK39_RS19020	COG0116	Belongs to the methyltransferase superfamily
AK39_RS19070	COG4499	WXG100 protein secretion system (Wss), protein YukC
AK39_RS19070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK39_RS19080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AK39_RS19085	COG3935	DnaD domain protein
AK39_RS19105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AK39_RS19105	COG1199	ATP-dependent helicase activity
AK39_RS19145	COG0438	transferase activity, transferring glycosyl groups
AK39_RS19150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AK39_RS19165	COG1694	Mazg nucleotide pyrophosphohydrolase
AK39_RS19170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_RS19180	COG2738	Putative neutral zinc metallopeptidase
AK39_RS19195	COG4347	Protein of unknown function (DUF1405)
AK39_RS19205	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AK39_RS19225	COG0457	Tetratricopeptide repeat
AK39_RS19230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AK39_RS19250	COG0142	geranyltranstransferase activity
AK39_RS19260	COG0142	geranyltranstransferase activity
AK39_RS19275	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK39_RS19345	COG0252	asparaginase activity
AK39_RS19350	COG0492	ferredoxin-NADP+ reductase activity
AK39_RS19370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AK39_RS19375	COG4862	establishment of competence for transformation
AK39_RS19395	COG1266	CAAX protease self-immunity
AK39_RS19400	COG0514	ATP-dependent DNA helicase (RecQ)
AK39_RS19405	COG4955	Helix-turn-helix domain
AK39_RS19410	COG1141	Ferredoxin
AK39_RS19415	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AK39_RS19430	COG2096	Adenosyltransferase
AK39_RS19435	COG5002	protein histidine kinase activity
AK39_RS19440	COG0745	RESPONSE REGULATOR receiver
AK39_RS19445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AK39_RS19450	COG1333	cytochrome c biogenesis protein
AK39_RS19460	COG1187	pseudouridine synthase activity
AK39_RS19465	COG0700	Nucleoside recognition
AK39_RS19470	COG2715	membrane protein required for spore maturation
AK39_RS19475	COG1686	Belongs to the peptidase S11 family
AK39_RS19480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK39_RS19495	COG0392	lysyltransferase activity
AK39_RS19495	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AK39_RS19515	COG5002	protein histidine kinase activity
AK39_RS19520	COG0582	viral genome integration into host DNA
AK39_RS19530	COG1801	Protein of unknown function DUF72
AK39_RS19535	COG3852	Histidine kinase
AK39_RS19550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK39_RS19555	COG1392	Phosphate transport regulator
AK39_RS19560	COG0306	phosphate transporter
AK39_RS19565	COG0730	response to heat
AK39_RS19585	COG1017	nitric oxide dioxygenase activity
AK39_RS19585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AK39_RS19610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AK39_RS19620	COG1114	Component of the transport system for branched-chain amino acids
AK39_RS19630	COG2197	response regulator
AK39_RS19635	COG4585	Histidine kinase
AK39_RS19640	COG4758	membrane
AK39_RS19655	COG1757	Na H antiporter
AK39_RS19675	COG0733	neurotransmitter:sodium symporter activity
AK39_RS19685	COG1648	precorrin-2 dehydrogenase activity
AK39_RS19705	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AK39_RS19710	COG0529	Catalyzes the synthesis of activated sulfate
AK39_RS19730	COG0019	diaminopimelate decarboxylase activity
AK39_RS19740	COG1368	sulfuric ester hydrolase activity
AK39_RS19745	COG1183	phosphatidylcholine synthase activity
AK39_RS19760	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AK39_RS19795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AK39_RS19820	COG0473	3-isopropylmalate dehydrogenase activity
AK39_RS19830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AK39_RS19835	COG0440	acetolactate synthase activity
AK39_RS19840	COG0028	Belongs to the TPP enzyme family
AK39_RS19845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK39_RS19875	COG3874	Sporulation protein YtfJ
AK39_RS19880	COG4709	membrane
AK39_RS19885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK39_RS19890	COG1301	dicarboxylic acid transport
AK39_RS19900	COG1846	Transcriptional regulator
AK39_RS19915	COG1968	undecaprenyl-diphosphatase activity
AK39_RS19920	COG0534	Mate efflux family protein
AK39_RS19940	COG3173	Aminoglycoside phosphotransferase
AK39_RS19955	COG0716	FMN binding
AK39_RS19980	COG1696	Membrane protein involved in D-alanine export
AK39_RS19990	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AK39_RS19995	COG2070	2-Nitropropane dioxygenase
AK39_RS20000	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK39_RS20010	COG1335	isochorismatase
AK39_RS20020	COG1522	sequence-specific DNA binding
AK39_RS20035	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK39_RS20040	COG1131	(ABC) transporter
AK39_RS20050	COG1131	(ABC) transporter
AK39_RS20055	COG1725	Transcriptional regulator
AK39_RS20060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK39_RS20065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK39_RS20080	COG1780	Probably involved in ribonucleotide reductase function
AK39_RS20115	COG4873	Protein conserved in bacteria
AK39_RS20130	COG0720	synthase
AK39_RS20140	COG5002	protein histidine kinase activity
AK39_RS20150	COG2318	DinB family
AK39_RS20160	COG1846	Transcriptional regulator
AK39_RS20165	COG3852	Histidine kinase
AK39_RS20175	COG2861	carbohydrate metabolic process
AK39_RS20200	COG1349	DNA-binding transcription factor activity
AK39_RS20230	COG1840	ABC-type Fe3 transport system, periplasmic component
AK39_RS20245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK39_RS20250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK39_RS20255	COG3243	poly(R)-hydroxyalkanoic acid synthase
AK39_RS20260	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS20280	COG2030	dehydratase
AK39_RS20290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK39_RS20295	COG0861	Integral membrane protein TerC family
AK39_RS20300	COG2116	formate transmembrane transporter activity
AK39_RS20310	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AK39_RS20330	COG2186	Transcriptional regulator
AK39_RS20335	COG5002	protein histidine kinase activity
AK39_RS20340	COG0745	RESPONSE REGULATOR receiver
AK39_RS20350	COG3835	regulator
AK39_RS20355	COG0277	FAD linked oxidase domain protein
AK39_RS20360	COG0247	lactate metabolic process
AK39_RS20365	COG2340	Cysteine-rich secretory protein family
AK39_RS20375	COG0564	pseudouridine synthase activity
AK39_RS20385	COG2409	Drug exporters of the RND superfamily
AK39_RS20395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AK39_RS20400	COG1177	transmembrane transport
AK39_RS20405	COG1176	ABC-type spermidine putrescine transport system, permease component I
AK39_RS20410	COG3842	ATPase activity
AK39_RS20415	COG1012	belongs to the aldehyde dehydrogenase family
AK39_RS20450	COG0681	Belongs to the peptidase S26 family
AK39_RS20455	COG1686	Belongs to the peptidase S11 family
AK39_RS20465	COG2226	methyltransferase
AK39_RS20525	COG1476	TRANSCRIPTIONal
AK39_RS20535	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK39_RS20585	COG5634	Uncharacterized conserved protein (DUF2278)
AK39_RS20590	COG1620	l-lactate permease
AK39_RS20625	COG0512	Glutamine amidotransferase of anthranilate synthase
AK39_RS20625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AK39_RS20640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK39_RS20645	COG5492	domain, Protein
AK39_RS20660	COG2382	esterase
AK39_RS20670	COG2153	protein acetylation
AK39_RS20715	COG1091	dTDP-4-dehydrorhamnose reductase activity
AK39_RS20730	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AK39_RS20750	COG0463	Glycosyl transferase, family 2
AK39_RS20750	COG0457	Tetratricopeptide repeat
AK39_RS20770	COG1216	Glycosyl transferase, family 2
AK39_RS20770	COG0463	Glycosyl transferase, family 2
AK39_RS20775	COG0772	Belongs to the SEDS family
AK39_RS20790	COG0564	pseudouridine synthase activity
AK39_RS20800	COG2357	RelA SpoT domain protein
AK39_RS20810	COG4116	CYTH
AK39_RS20815	COG2346	COG2346, Truncated hemoglobins
AK39_RS20820	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AK39_RS20830	COG1164	Oligoendopeptidase f
AK39_RS20840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK39_RS20845	COG4862	establishment of competence for transformation
AK39_RS20850	COG0861	Integral membrane protein TerC family
AK39_RS20870	COG4166	transmembrane transport
AK39_RS20875	COG0534	Mate efflux family protein
AK39_RS20880	COG4608	Belongs to the ABC transporter superfamily
AK39_RS20885	COG0444	Belongs to the ABC transporter superfamily
AK39_RS20890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK39_RS20895	COG0601	transmembrane transport
AK39_RS20900	COG4166	transmembrane transport
AK39_RS20910	COG0180	Tryptophanyl-tRNA synthetase
AK39_RS20920	COG5504	Zn-dependent protease
AK39_RS20925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AK39_RS20930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_RS20945	COG2267	carboxylic ester hydrolase activity
AK39_RS20955	COG0542	response to heat
AK39_RS20970	COG0561	phosphatase activity
AK39_RS20985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_RS20995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK39_RS21005	COG2996	Protein conserved in bacteria
AK39_RS21030	COG0004	ammonium transporteR
AK39_RS21035	COG0753	catalase activity
AK39_RS21040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AK39_RS21045	COG0367	asparagine synthase
AK39_RS21070	COG0179	Fumarylacetoacetate (FAA) hydrolase
AK39_RS21115	COG1074	ATP-dependent DNA helicase activity
AK39_RS21120	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AK39_RS21130	COG0398	Pfam SNARE associated Golgi protein
AK39_RS21135	COG4903	ComK protein
AK39_RS21160	COG2224	Isocitrate lyase
AK39_RS21165	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AK39_RS21185	COG0697	spore germination
AK39_RS21190	COG0840	transmembrane signaling receptor activity
AK39_RS21195	COG0501	Belongs to the peptidase M48B family
AK39_RS21220	COG0745	RESPONSE REGULATOR receiver
AK39_RS21225	COG2205	protein histidine kinase activity
AK39_RS21240	COG3708	Transcriptional regulator
AK39_RS21240	COG2207	Transcriptional regulator
AK39_RS21245	COG1595	DNA-templated transcription, initiation
AK39_RS21255	COG1078	dGTPase activity
AK39_RS21260	COG1408	metallophosphoesterase
AK39_RS21305	COG3209	COG3209 Rhs family protein
AK39_RS21335	COG0318	PFAM AMP-dependent synthetase and ligase
AK39_RS21345	COG0095	Lipoate-protein ligase
AK39_RS21350	COG1234	tRNA 3'-trailer cleavage
AK39_RS21360	COG1609	Transcriptional regulator
AK39_RS21385	COG1511	domain protein
AK39_RS21390	COG1309	transcriptional regulator
AK39_RS21425	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AK39_RS21430	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AK39_RS21435	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AK39_RS21440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK39_RS21445	COG2329	Antibiotic biosynthesis monooxygenase
AK39_RS21450	COG3428	Bacterial PH domain
AK39_RS21455	COG3402	PFAM membrane-flanked domain
AK39_RS21500	COG3428	Bacterial PH domain
AK39_RS21510	COG3402	PFAM membrane-flanked domain
AK39_RS21520	COG1309	transcriptional regulator
AK39_RS21530	COG4473	ABC transporter
AK39_RS21535	COG1131	(ABC) transporter
AK39_RS21540	COG0537	adenosine 5'-monophosphoramidase activity
AK39_RS21545	COG4980	gas vesicle protein
AK39_RS21570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK39_RS21575	COG3973	AAA domain
AK39_RS21585	COG0477	Major facilitator Superfamily
AK39_RS21590	COG0477	Major facilitator Superfamily
AK39_RS21630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AK39_RS21640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AK39_RS21645	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AK39_RS21665	COG2267	carboxylic ester hydrolase activity
AK39_RS21670	COG0457	Tetratricopeptide repeat
AK39_RS21675	COG0346	lactoylglutathione lyase activity
AK39_RS21680	COG0346	lactoylglutathione lyase activity
AK39_RS21685	COG2814	Major facilitator Superfamily
AK39_RS21690	COG1309	transcriptional regulator
AK39_RS21710	COG4717	serine-type aminopeptidase activity
AK39_RS21715	COG0420	3'-5' exonuclease activity
AK39_RS21775	COG0784	Response regulator, receiver
AK39_RS21775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK39_RS21775	COG2198	Histidine kinase
AK39_RS21775	COG2205	protein histidine kinase activity
AK39_RS21780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AK39_RS21785	COG2208	phosphoserine phosphatase activity
AK39_RS21795	COG1191	sigma factor activity
AK39_RS21820	COG3237	CsbD-like
AK39_RS21870	COG3437	response regulator, receiver
AK39_RS21870	COG2770	Histidine kinase
AK39_RS21895	COG1959	2 iron, 2 sulfur cluster binding
AK39_RS21900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AK39_RS21915	COG2376	Dihydroxyacetone kinase
AK39_RS21935	COG1183	phosphatidylcholine synthase activity
AK39_RS21955	COG1309	transcriptional regulator
AK39_RS21960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AK39_RS21960	COG3320	Male sterility
AK39_RS22010	COG0477	Major facilitator Superfamily
AK39_RS22050	COG0305	Participates in initiation and elongation during chromosome replication
AK39_RS22065	COG4978	Transcriptional regulator
AK39_RS22065	COG0789	Transcriptional regulator
AK39_RS22095	COG3181	Tripartite tricarboxylate transporter family receptor
AK39_RS22100	COG4565	transcriptional regulatory protein
AK39_RS22105	COG3290	protein histidine kinase activity
AK39_RS22110	COG0477	Major facilitator Superfamily
AK39_RS22140	COG4608	Belongs to the ABC transporter superfamily
AK39_RS22150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK39_RS22155	COG0601	transmembrane transport
AK39_RS22195	COG3938	Belongs to the proline racemase family
AK39_RS22215	COG1363	Peptidase, m42
AK39_RS22235	COG1024	Enoyl-CoA hydratase
AK39_RS22250	COG1696	Membrane protein involved in D-alanine export
AK39_RS22265	COG4196	transglutaminase domain protein
AK39_RS22270	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK39_RS22280	COG2244	polysaccharide biosynthetic process
AK39_RS22285	COG0653	protein targeting
AK39_RS22305	COG0659	secondary active sulfate transmembrane transporter activity
AK39_RS22320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AK39_RS22335	COG0561	phosphatase activity
AK39_RS22350	COG3527	Alpha-acetolactate decarboxylase
AK39_RS22355	COG0028	Belongs to the TPP enzyme family
AK39_RS22385	COG0189	ligase activity
AK39_RS22400	COG1126	abc transporter atp-binding protein
AK39_RS22405	COG0765	amino acid transport
AK39_RS22410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK39_RS22420	COG1132	(ABC) transporter
AK39_RS22430	COG1012	belongs to the aldehyde dehydrogenase family
AK39_RS22440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AK39_RS22445	COG0531	amino acid
AK39_RS22455	COG0753	catalase activity
AK39_RS22455	COG0693	protein deglycase activity
AK39_RS22460	COG0693	protein deglycase activity
AK39_RS22470	COG2211	Major facilitator Superfamily
AK39_RS22475	COG4533	DNA binding
AK39_RS22480	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK39_RS22490	COG1733	regulation of RNA biosynthetic process
AK39_RS22495	COG2814	Major facilitator Superfamily
AK39_RS22500	COG1309	transcriptional regulator
AK39_RS22505	COG2076	Multidrug Resistance protein
AK39_RS22520	COG1522	sequence-specific DNA binding
AK39_RS22525	COG0697	spore germination
AK39_RS22540	COG2259	Doxx family
AK39_RS22550	COG1263	PTS System
AK39_RS22550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_RS22560	COG1737	Transcriptional regulator
AK39_RS22570	COG0475	glutathione-regulated potassium exporter activity
AK39_RS22575	COG0531	amino acid
AK39_RS22610	COG0586	Pfam SNARE associated Golgi protein
AK39_RS22645	COG3546	catalase activity
AK39_RS22650	COG1114	Component of the transport system for branched-chain amino acids
AK39_RS22665	COG5522	Integral membrane protein (intg_mem_TP0381)
AK39_RS22675	COG1136	(ABC) transporter
AK39_RS22680	COG0577	efflux transmembrane transporter activity
AK39_RS22685	COG3584	3D domain protein
AK39_RS22685	COG1388	LysM domain
AK39_RS22705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK39_RS22710	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK39_RS22715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK39_RS22715	COG3711	transcriptional antiterminator
AK39_RS22730	COG1283	sodium-dependent phosphate transmembrane transporter activity
AK39_RS22735	COG0604	alcohol dehydrogenase
AK39_RS22740	COG1316	TRANSCRIPTIONal
AK39_RS22750	COG0730	response to heat
AK39_RS22755	COG2210	Belongs to the sulfur carrier protein TusA family
AK39_RS22765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_RS22770	COG0425	Belongs to the sulfur carrier protein TusA family
AK39_RS22775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_RS22775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK39_RS22780	COG0425	Belongs to the sulfur carrier protein TusA family
AK39_RS22780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK39_RS22785	COG1937	Protein conserved in bacteria
AK39_RS22790	COG0446	pyridine nucleotide-disulphide oxidoreductase
AK39_RS22815	COG2719	SpoVR family
AK39_RS22820	COG0778	Nitroreductase
AK39_RS22860	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AK39_RS22865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK39_RS22875	COG1609	Transcriptional regulator
AK39_RS22880	COG1263	PTS System
AK39_RS22880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_RS22885	COG1621	beta-fructofuranosidase activity
AK39_RS22890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AK39_RS22905	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS22910	COG2252	PERMEase
AK39_RS22925	COG1846	Transcriptional regulator
AK39_RS22930	COG2814	Major facilitator Superfamily
AK39_RS22935	COG2205	protein histidine kinase activity
AK39_RS22980	COG0351	phosphomethylpyrimidine kinase
AK39_RS22985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK39_RS22995	COG2104	thiamine diphosphate biosynthetic process
AK39_RS23000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK39_RS23005	COG0352	thiamine-phosphate diphosphorylase activity
AK39_RS23010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK39_RS23015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK39_RS23020	COG1116	anion transmembrane transporter activity
AK39_RS23025	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AK39_RS23050	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AK39_RS23170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AK39_RS23180	COG0581	inorganic phosphate transmembrane transporter activity
AK39_RS23185	COG0573	inorganic phosphate transmembrane transporter activity
AK39_RS23190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AK39_RS23195	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK39_RS23195	COG1918	ferrous iron import across plasma membrane
AK39_RS23200	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK39_RS23205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK39_RS23220	COG0531	amino acid
AK39_RS23225	COG0697	spore germination
AK39_RS23230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK39_RS23245	COG4990	cell redox homeostasis
AK39_RS23250	COG0833	amino acid
AK39_RS23255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AK39_RS23260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AK39_RS23275	COG0475	glutathione-regulated potassium exporter activity
AK39_RS23275	COG0569	domain protein
AK39_RS23300	COG2252	PERMEase
AK39_RS23305	COG1113	amino acid transport
AK39_RS23320	COG1114	Component of the transport system for branched-chain amino acids
AK39_RS23325	COG3104	oligopeptide transport
AK39_RS23340	COG1476	TRANSCRIPTIONal
AK39_RS23345	COG1388	LysM domain
AK39_RS23345	COG3584	3D domain protein
AK39_RS23350	COG0840	transmembrane signaling receptor activity
AK39_RS23355	COG1968	undecaprenyl-diphosphatase activity
AK39_RS23380	COG3568	Endonuclease Exonuclease Phosphatase
AK39_RS23395	COG1063	alcohol dehydrogenase
AK39_RS23420	COG1879	ABC-type sugar transport system periplasmic component
AK39_RS23425	COG1172	Belongs to the binding-protein-dependent transport system permease family
AK39_RS23440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AK39_RS23445	COG1609	Transcriptional regulator
AK39_RS23450	COG0477	Major facilitator Superfamily
AK39_RS23455	COG0477	Major facilitator Superfamily
AK39_RS23460	COG1846	Transcriptional regulator
AK39_RS23465	COG2271	Major facilitator Superfamily
AK39_RS23475	COG4608	Belongs to the ABC transporter superfamily
AK39_RS23480	COG0601	transmembrane transport
AK39_RS23490	COG0747	negative chemotaxis
AK39_RS23505	COG0659	secondary active sulfate transmembrane transporter activity
AK39_RS23520	COG5002	protein histidine kinase activity
AK39_RS23525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AK39_RS23530	COG2378	regulation of single-species biofilm formation
AK39_RS23555	COG0833	amino acid
AK39_RS23560	COG0765	amino acid transport
AK39_RS23565	COG0765	amino acid transport
AK39_RS23570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK39_RS23575	COG1126	abc transporter atp-binding protein
AK39_RS23580	COG1115	amino acid carrier protein
AK39_RS23585	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK39_RS23595	COG0697	spore germination
AK39_RS23610	COG0366	Alpha amylase catalytic
AK39_RS23615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_RS23615	COG1263	PTS System
AK39_RS23620	COG2188	Transcriptional regulator
AK39_RS23625	COG0531	amino acid
AK39_RS23645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK39_RS23650	COG0714	Associated with various cellular activities
AK39_RS23655	COG4548	von Willebrand factor, type A
AK39_RS23665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK39_RS23670	COG0156	8-amino-7-oxononanoate synthase activity
AK39_RS23675	COG2226	methyltransferase
AK39_RS23685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_RS23690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_RS23695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_RS23700	COG3104	oligopeptide transport
AK39_RS23715	COG1620	l-lactate permease
AK39_RS23720	COG1027	Aspartate ammonia-lyase
AK39_RS23725	COG1253	flavin adenine dinucleotide binding
AK39_RS23730	COG0346	lactoylglutathione lyase activity
AK39_RS23735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_RS23740	COG1316	TRANSCRIPTIONal
AK39_RS23745	COG2720	vancomycin resistance protein
AK39_RS23765	COG3227	Zinc metalloprotease (Elastase)
AK39_RS23775	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AK39_RS23780	COG2217	Heavy metal translocating P-type atpase
AK39_RS23785	COG0640	Transcriptional regulator
AK39_RS23790	COG0531	amino acid
AK39_RS23805	COG2427	Protein of unknown function (DUF1641)
AK39_RS23810	COG3383	formate dehydrogenase (NAD+) activity
AK39_RS23815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AK39_RS23820	COG0454	-acetyltransferase
AK39_RS23820	COG0456	acetyltransferase
AK39_RS23830	COG0745	RESPONSE REGULATOR receiver
AK39_RS23835	COG5002	protein histidine kinase activity
AK39_RS23845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK39_RS23860	COG0281	malic enzyme
AK39_RS23865	COG3493	citrate carrier protein
AK39_RS23870	COG4565	transcriptional regulatory protein
AK39_RS23875	COG3290	protein histidine kinase activity
AK39_RS23885	COG4990	cell redox homeostasis
AK39_RS23895	COG5002	protein histidine kinase activity
AK39_RS23900	COG0745	RESPONSE REGULATOR receiver
AK39_RS23905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AK39_RS23915	COG0395	ABC-type sugar transport system, permease component
AK39_RS23920	COG1175	transmembrane transport
AK39_RS23925	COG3842	ATPase activity
AK39_RS23930	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AK39_RS23950	COG2851	Citrate transporter
AK39_RS23960	COG3290	protein histidine kinase activity
AK39_RS23970	COG2268	Band 7 protein
AK39_RS23975	COG1585	Membrane protein implicated in regulation of membrane protease activity
AK39_RS23985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK39_RS24010	COG2766	serine protein kinase
AK39_RS24025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AK39_RS24035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AK39_RS24045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AK39_RS24050	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AK39_RS24165	COG0735	belongs to the Fur family
AK39_RS24170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AK39_RS24190	COG4555	ABC transporter
AK39_RS24200	COG0069	glutamate synthase activity
AK39_RS24200	COG0070	glutamate synthase
AK39_RS24200	COG0067	glutamate synthase
AK39_RS24205	COG4129	membrane
AK39_RS24210	COG1132	(ABC) transporter
AK39_RS24235	COG1194	a g-specific adenine glycosylase
AK39_RS24240	COG1988	membrane-bound metal-dependent
AK39_RS24270	COG1090	epimerase
AK39_RS24275	COG1228	amidohydrolase
AK39_RS24295	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AK39_RS24315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AK39_RS24315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK39_RS24330	COG0463	Glycosyl transferase, family 2
AK39_RS24345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK39_RS24350	COG1263	PTS System
AK39_RS24350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_RS24385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK39_RS24390	COG0833	amino acid
AK39_RS24400	COG3829	transcription factor binding
AK39_RS24410	COG0101	tRNA pseudouridine synthase activity
AK39_RS24535	COG0582	viral genome integration into host DNA
AK39_RS24540	COG0582	viral genome integration into host DNA
AK39_RS24635	COG1484	DNA-dependent DNA replication
AK39_RS24670	COG1396	sequence-specific DNA binding
AK39_RS24685	COG1396	sequence-specific DNA binding
AK39_RS24690	COG0582	viral genome integration into host DNA
AK39_RS24695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AK39_RS24700	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AK39_RS24725	COG0535	radical SAM domain protein
AK39_RS24735	COG0387	Pfam Sodium calcium exchanger
AK39_RS24740	COG3871	stress protein (general stress protein 26)
AK39_RS24755	COG0586	Pfam SNARE associated Golgi protein
AK39_RS24775	COG0697	spore germination
AK39_RS24780	COG2217	Heavy metal translocating P-type atpase
AK39_RS24785	COG1295	ribonuclease BN
AK39_RS24795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AK39_RS24810	COG3853	Toxic anion resistance protein (TelA)
AK39_RS24820	COG0861	Integral membrane protein TerC family
AK39_RS24825	COG2310	stress, protein
AK39_RS24830	COG2310	stress, protein
AK39_RS24835	COG2310	stress, protein
AK39_RS24850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AK39_RS24865	COG2270	Major facilitator Superfamily
AK39_RS24910	COG0488	(ABC) transporter
AK39_RS24915	COG1116	anion transmembrane transporter activity
AK39_RS24925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK39_RS24940	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AK39_RS24970	COG2190	(PTS) system
AK39_RS24970	COG1263	PTS System
AK39_RS24970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK39_RS24975	COG0366	Alpha amylase catalytic
AK39_RS24980	COG0840	transmembrane signaling receptor activity
AK39_RS24985	COG0840	transmembrane signaling receptor activity
AK39_RS24995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK39_RS25000	COG0765	amino acid transport
AK39_RS25010	COG0723	plastoquinol--plastocyanin reductase activity
AK39_RS25010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK39_RS25015	COG2814	Major facilitator Superfamily
AK39_RS25020	COG3541	Predicted nucleotidyltransferase
AK39_RS25040	COG5002	protein histidine kinase activity
AK39_RS25075	COG0166	Belongs to the GPI family
AK39_RS25095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_RS25100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_RS25105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_RS25125	COG0450	alkyl hydroperoxide reductase
AK39_RS25140	COG1473	amidohydrolase
AK39_RS25145	COG1757	Na H antiporter
AK39_RS25170	COG4807	Protein conserved in bacteria
AK39_RS25180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AK39_RS25185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AK39_RS25190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_RS25205	COG2309	aminopeptidase activity
AK39_RS25210	COG2076	Multidrug Resistance protein
AK39_RS25215	COG1012	belongs to the aldehyde dehydrogenase family
AK39_RS25225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AK39_RS25230	COG0546	phosphoglycolate phosphatase activity
AK39_RS25235	COG1597	lipid kinase activity
AK39_RS25260	COG1846	Transcriptional regulator
AK39_RS25280	COG1464	Belongs to the NlpA lipoprotein family
AK39_RS25285	COG2011	ABC-type metal ion transport system permease component
AK39_RS25290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AK39_RS25295	COG1335	isochorismatase
AK39_RS25315	COG4851	CamS sex pheromone cAM373 precursor
AK39_RS25325	COG0210	DNA helicase
AK39_RS25350	COG0151	Belongs to the GarS family
AK39_RS25360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AK39_RS25370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AK39_RS25385	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AK39_RS25395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AK39_RS25400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AK39_RS25405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AK39_RS25430	COG0745	RESPONSE REGULATOR receiver
AK39_RS25435	COG2205	protein histidine kinase activity
AK39_RS25450	COG1968	undecaprenyl-diphosphatase activity
AK39_RS25490	COG2226	methyltransferase
AK39_RS25520	COG5002	protein histidine kinase activity
AK39_RS25530	COG2252	PERMEase
AK39_RS25550	COG1266	CAAX protease self-immunity
AK39_RS25565	COG0488	(ABC) transporter
AK39_RS25575	COG0456	acetyltransferase
AK39_RS25580	COG1214	PFAM Peptidase M22, glycoprotease
AK39_RS25585	COG0802	atpase or kinase
AK39_RS25680	COG2183	response to ionizing radiation
AK39_RS25685	COG2337	Toxic component of a toxin-antitoxin (TA) module
AK39_RS25690	COG0864	Transcriptional regulator
AK39_RS25695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AK39_RS25700	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AK39_RS25710	COG0705	Rhomboid family
AK39_RS25710	COG0457	Tetratricopeptide repeat
AK39_RS25715	COG4294	response to UV
AK39_RS25725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AK39_RS25740	COG2814	Major facilitator Superfamily
AK39_RS25750	COG0179	Fumarylacetoacetate (FAA) hydrolase
AK39_RS25755	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AK39_RS25780	COG4608	Belongs to the ABC transporter superfamily
AK39_RS25785	COG0444	Belongs to the ABC transporter superfamily
AK39_RS25790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK39_RS25795	COG0601	transmembrane transport
AK39_RS25800	COG0747	negative chemotaxis
AK39_RS25815	COG0488	(ABC) transporter
AK39_RS25840	COG5298	Protein conserved in bacteria
AK39_RS25845	COG0084	hydrolase, TatD family'
AK39_RS25860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK39_RS25870	COG1609	Transcriptional regulator
AK39_RS25880	COG0204	Acyl-transferase
AK39_RS25890	COG0697	spore germination
AK39_RS25895	COG0583	DNA-binding transcription factor activity
AK39_RS25910	COG1910	domain protein
AK39_RS25915	COG0725	ABC transporter, periplasmic molybdate-binding protein
AK39_RS25920	COG0725	ABC transporter, periplasmic molybdate-binding protein
AK39_RS25925	COG4149	molybdate abc transporter
AK39_RS25945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK39_RS25950	COG0656	L-ascorbic acid biosynthetic process
AK39_RS25955	COG4166	transmembrane transport
AK39_RS25960	COG4166	transmembrane transport
AK39_RS25975	COG2207	Transcriptional regulator
AK39_RS25985	COG4166	transmembrane transport
AK39_RS25990	COG4608	Belongs to the ABC transporter superfamily
AK39_RS25995	COG0444	Belongs to the ABC transporter superfamily
AK39_RS26000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK39_RS26005	COG0601	transmembrane transport
AK39_RS26020	COG2814	Major facilitator Superfamily
AK39_RS26030	COG2271	Major facilitator Superfamily
AK39_RS26035	COG0277	FAD linked oxidase domain protein
AK39_RS26045	COG0604	alcohol dehydrogenase
AK39_RS26050	COG1464	Belongs to the NlpA lipoprotein family
AK39_RS26055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AK39_RS26060	COG2011	ABC-type metal ion transport system permease component
AK39_RS26065	COG1028	Short-chain dehydrogenase reductase Sdr
AK39_RS26100	COG0823	Involved in the tonB-independent uptake of proteins
AK39_RS26100	COG1506	peptidase
AK39_RS26100	COG4946	Tricorn protease homolog
AK39_RS26105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AK39_RS26125	COG0596	Alpha beta hydrolase
AK39_RS26130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AK39_RS26145	COG4856	YbbR-like protein
AK39_RS26150	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AK39_RS26235	COG0726	polysaccharide deacetylase
AK39_RS26240	COG2194	sulfuric ester hydrolase activity
AK39_RS26250	COG0489	protein tyrosine kinase activity
AK39_RS26255	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK39_RS26280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AK39_RS26315	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AK39_RS26325	COG0024	Methionine aminopeptidase
AK39_RS26335	COG0201	protein transport
AK39_RS26395	COG0255	Belongs to the universal ribosomal protein uL29 family
AK39_RS26465	COG1358	cellular component organization or biogenesis
AK39_RS26470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AK39_RS26480	COG2813	Specifically methylates the guanine in position
AK39_RS26500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AK39_RS26505	COG0250	Participates in transcription elongation, termination and antitermination
AK39_RS26510	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AK39_RS26525	COG3688	RNA-binding protein containing a PIN domain
AK39_RS26530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AK39_RS26545	COG1045	serine acetyltransferase
AK39_RS26565	COG4956	integral membrane protein (PIN domain superfamily)
AK39_RS26575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AK39_RS26580	COG0542	response to heat
AK39_RS26590	COG3880	PFAM UvrB UvrC protein
AK39_RS26620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AK39_RS26625	COG1396	sequence-specific DNA binding
AK39_RS26630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AK39_RS26635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AK39_RS26640	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AK39_RS26645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK39_RS26650	COG0512	Glutamine amidotransferase of anthranilate synthase
AK39_RS26655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AK39_RS26660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK39_RS26675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AK39_RS26680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AK39_RS26685	COG0037	tRNA processing
AK39_RS26690	COG2208	phosphoserine phosphatase activity
AK39_RS26705	COG1098	S1 RNA binding domain
AK39_RS26725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AK39_RS26730	COG3956	TIGRFAM MazG family protein
AK39_RS26735	COG2244	polysaccharide biosynthetic process
AK39_RS26740	COG2002	toxin-antitoxin pair type II binding
AK39_RS26745	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AK39_RS26775	COG0251	oxidation-reduction process
AK39_RS26780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AK39_RS26795	COG4466	Protein conserved in bacteria
AK39_RS26810	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AK39_RS26815	COG0084	hydrolase, TatD family'
AK39_RS26820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK39_RS26820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK39_RS26825	COG2002	toxin-antitoxin pair type II binding
AK39_RS26830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AK39_RS26840	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AK39_RS26850	COG1774	PSP1 C-terminal conserved region
AK39_RS26855	COG0470	DNA polymerase III
AK39_RS26865	COG1982	Orn Lys Arg decarboxylase major
AK39_RS26920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AK39_RS26925	COG0590	tRNA wobble adenosine to inosine editing
AK39_RS26935	COG1335	isochorismatase
AK39_RS26940	COG1428	Deoxynucleoside kinase
AK39_RS26945	COG1428	Deoxynucleoside kinase
AK39_RS26975	COG1686	Belongs to the peptidase S11 family
AK39_RS26980	COG0517	IMP dehydrogenase activity
AK39_RS26980	COG0516	GMP reductase activity
AK39_RS27015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AK39_RS27020	COG0187	DNA topoisomerase II activity
AK39_RS27030	COG2501	S4 domain
AK39_RS27035	COG0592	DNA-directed DNA polymerase activity
AK39_RS27045	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AK39_RS27055	COG0706	membrane insertase activity
AK39_RS27060	COG1847	R3H domain protein
AK39_RS27085	COG1192	Involved in chromosome partitioning
AK39_RS27090	COG1475	DNA binding
AK39_RS27100	COG0668	transmembrane transport
AK39_RS27105	COG4481	Protein conserved in bacteria
AK39_RS27110	COG0012	GTP binding
AK39_RS27120	COG0629	single-stranded DNA binding
AK39_RS27130	COG4241	membrane
AK39_RS27135	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AK39_RS27145	COG0305	Participates in initiation and elongation during chromosome replication
AK39_RS27175	COG0745	RESPONSE REGULATOR receiver
AK39_RS27180	COG5002	protein histidine kinase activity
AK39_RS27185	COG4863	YycH protein
AK39_RS27190	COG4853	Protein conserved in bacteria
AK39_RS27195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AK39_RS27200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK39_RS27220	COG1164	Oligoendopeptidase f
AK39_RS27225	COG0516	GMP reductase activity
AK39_RS27245	COG1272	protein, Hemolysin III
AK39_RS27250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AK39_RS27270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK39_RS27275	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AK39_RS27280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK39_RS27285	COG2814	Major facilitator Superfamily
AK39_RS27290	COG3275	phosphorelay sensor kinase activity
AK39_RS27295	COG3279	Response regulator of the LytR AlgR family
AK39_RS27310	COG0628	permease
AK39_RS27315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK39_RS27315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK39_RS27320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AK39_RS27325	COG1309	transcriptional regulator
AK39_RS27330	COG0463	Glycosyl transferase, family 2
AK39_RS27355	COG0488	(ABC) transporter
AK39_RS27370	COG1607	acyl-coa hydrolase
AK39_RS27380	COG0840	transmembrane signaling receptor activity
AK39_RS27405	COG0477	Major facilitator Superfamily
AK39_RS27410	COG3279	Response regulator of the LytR AlgR family
AK39_RS27415	COG1966	Carbon starvation protein
AK39_RS27420	COG2879	small protein
AK39_RS27425	COG3706	GGDEF domain
AK39_RS27430	COG0351	phosphomethylpyrimidine kinase
AK39_RS27440	COG2197	response regulator
AK39_RS27450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AK39_RS27455	COG1011	Hydrolase
AK39_RS27465	COG2873	o-acetylhomoserine
AK39_RS27475	COG0460	homoserine dehydrogenase
AK39_RS27485	COG1609	Transcriptional regulator
AK39_RS27490	COG2755	lipolytic protein G-D-S-L family
AK39_RS27495	COG1131	(ABC) transporter
AK39_RS27500	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK39_RS27510	COG2814	Major facilitator Superfamily
AK39_RS27515	COG0561	phosphatase activity
AK39_RS27520	COG2233	PERMEase
AK39_RS27525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AK39_RS27535	COG2363	Small membrane protein
AK39_RS27545	COG3773	Cell wall hydrolase
AK39_RS27560	COG0280	phosphate acetyltransferase
AK39_RS27565	COG0095	Lipoate-protein ligase
AK39_RS27585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_RS27590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_RS27595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK39_RS27600	COG1120	ATPase activity
AK39_RS27605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK39_RS27610	COG1078	dGTPase activity
AK39_RS27620	COG1994	Peptidase M50
AK39_RS27630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK39_RS27635	COG0584	glycerophosphoryl diester phosphodiesterase
AK39_RS27640	COG0789	Transcriptional regulator
AK39_RS27645	COG2814	Major facilitator Superfamily
AK39_RS27655	COG0010	Belongs to the arginase family
AK39_RS27675	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK39_RS27680	COG4506	Protein conserved in bacteria
AK39_RS27685	COG0018	arginyl-trna synthetase
AK39_RS27690	COG1595	DNA-templated transcription, initiation
AK39_RS27710	COG2234	aminopeptidase activity
AK39_RS27730	COG0024	Methionine aminopeptidase
AK39_RS27735	COG1131	(ABC) transporter
AK39_RS27740	COG0842	Transport permease protein
AK39_RS27745	COG4585	Histidine kinase
AK39_RS27750	COG2197	response regulator
AK39_RS27765	COG5001	Diguanylate cyclase
AK39_RS27765	COG3300	MHYT domain
AK39_RS27775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK39_RS27780	COG2181	nitrate reductase activity
AK39_RS27780	COG0247	lactate metabolic process
AK39_RS27785	COG0183	Belongs to the thiolase family
AK39_RS27790	COG1250	3-hydroxyacyl-CoA dehydrogenase
AK39_RS27795	COG1960	acyl-CoA dehydrogenase activity
AK39_RS27800	COG1960	acyl-CoA dehydrogenase activity
AK39_RS27810	COG3343	RNA polymerase activity
AK39_RS27820	COG4821	SIS domain
AK39_RS27840	COG1494	fructose-1,6-bisphosphatase
AK39_RS27845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AK39_RS27865	COG2890	protein-(glutamine-N5) methyltransferase activity
AK39_RS27880	COG0009	L-threonylcarbamoyladenylate synthase
AK39_RS27895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AK39_RS27900	COG2259	Doxx family
AK39_RS27905	COG2190	(PTS) system
AK39_RS27915	COG0698	ribose 5-phosphate isomerase
AK39_RS27950	COG0356	it plays a direct role in the translocation of protons across the membrane
AK39_RS28000	COG3300	MHYT domain
AK39_RS28000	COG5001	Diguanylate cyclase
AK39_RS28015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AK39_RS28020	COG0649	NAD binding
AK39_RS28035	COG0839	Belongs to the complex I subunit 6 family
AK39_RS28045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AK39_RS28050	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AK39_RS28055	COG1007	ATP synthesis coupled electron transport
AK39_RS28060	COG4836	Membrane
AK39_RS28075	COG2385	sporulation resulting in formation of a cellular spore
AK39_RS28080	COG4555	ABC transporter
AK39_RS28085	COG3279	Response regulator of the LytR AlgR family
AK39_RS28100	COG0739	heme binding
AK39_RS28115	COG1609	Transcriptional regulator
AK39_RS28160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AK39_RS28165	COG1682	transport, permease protein
AK39_RS28170	COG1134	teichoic acid transport
AK39_RS28175	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AK39_RS28195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AK39_RS28200	COG0745	RESPONSE REGULATOR receiver
AK39_RS28205	COG5002	protein histidine kinase activity
AK39_RS28240	COG1136	(ABC) transporter
AK39_RS28245	COG0577	efflux transmembrane transporter activity
AK39_RS28285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK39_RS28290	COG4715	Zinc finger, swim domain protein
AK39_RS28315	COG3584	3D domain protein
AK39_RS28315	COG1388	LysM domain
AK39_RS28320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK39_RS28340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK39_RS28355	COG1368	sulfuric ester hydrolase activity
AK39_RS28365	COG2389	metal-binding protein
AK39_RS28375	COG1620	l-lactate permease
AK39_RS28385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK39_RS28390	COG1294	oxidase, subunit
AK39_RS28395	COG1271	oxidase subunit
AK39_RS28410	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AK39_RS28415	COG0583	DNA-binding transcription factor activity
AK39_RS28420	COG1511	domain protein
AK39_RS28425	COG0346	lactoylglutathione lyase activity
AK39_RS28435	COG1301	dicarboxylic acid transport
AK39_RS28440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK39_RS28450	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK39_RS28455	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AK39_RS28460	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AK39_RS28470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK39_RS28475	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK39_RS28480	COG1486	melibiose metabolic process
AK39_RS28485	COG3394	polysaccharide catabolic process
AK39_RS28500	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AK39_RS28500	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AK39_RS28510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AK39_RS28515	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AK39_RS28520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AK39_RS28525	COG1316	TRANSCRIPTIONal
AK39_RS28530	COG1739	Uncharacterized protein family UPF0029
AK39_RS28535	COG1307	EDD domain protein, DegV family
AK39_RS28545	COG1733	regulation of RNA biosynthetic process
AK39_RS28550	COG1388	LysM domain
AK39_RS28550	COG0791	NLP P60 protein
AK39_RS28555	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AK39_RS28560	COG1040	competence protein
AK39_RS28565	COG1278	Cold shock
AK39_RS28570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AK39_RS28575	COG0653	protein targeting
AK39_RS28580	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AK39_RS28595	COG2884	Cell division ATP-binding protein ftsE
AK39_RS28600	COG2177	Part of the ABC transporter FtsEX involved in
AK39_RS28605	COG0793	Belongs to the peptidase S41A family
AK39_RS28605	COG3409	Peptidoglycan-binding domain 1 protein
AK39_RS28610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK39_RS28615	COG1132	(ABC) transporter
AK39_RS28625	COG0488	(ABC) transporter
AK39_RS28630	COG0655	NAD(P)H dehydrogenase (quinone) activity
AK39_RS28640	COG0583	DNA-binding transcription factor activity
AK39_RS28645	COG2855	membrane
AK39_RS28670	COG0789	Transcriptional regulator
AK39_RS28690	COG0556	nucleotide-excision repair
AK39_RS28695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK39_RS28705	COG1950	PFAM Membrane protein of
AK39_RS28725	COG0110	maltose O-acetyltransferase activity
AK39_RS28730	COG0457	Tetratricopeptide repeat
AK39_RS28735	COG0492	ferredoxin-NADP+ reductase activity
AK39_RS28745	COG1051	belongs to the nudix hydrolase family
AK39_RS28755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AK39_RS28765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK39_RS28770	COG0740	serine-type endopeptidase activity
AK39_RS28775	COG2323	membrane
AK39_RS28790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK39_RS28815	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AK39_RS28865	COG2376	Dihydroxyacetone kinase