locus-tag	class	description
I5S86_RS00020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_RS00025	COG5001	Diguanylate cyclase
I5S86_RS00025	COG3300	MHYT domain
I5S86_RS00035	COG1802	Transcriptional regulator
I5S86_RS00090	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS00095	COG0583	DNA-binding transcription factor activity
I5S86_RS00115	COG0427	acetyl-CoA hydrolase
I5S86_RS00150	COG2851	Citrate transporter
I5S86_RS00155	COG0861	Integral membrane protein TerC family
I5S86_RS00160	COG1283	sodium-dependent phosphate transmembrane transporter activity
I5S86_RS00175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5S86_RS00180	COG1127	ABC transporter
I5S86_RS00195	COG0700	Nucleoside recognition
I5S86_RS00200	COG1301	dicarboxylic acid transport
I5S86_RS00225	COG2204	response regulator
I5S86_RS00230	COG5002	protein histidine kinase activity
I5S86_RS00235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5S86_RS00240	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5S86_RS00255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5S86_RS00265	COG3245	cytochrome
I5S86_RS00270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I5S86_RS00290	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I5S86_RS00295	COG0735	belongs to the Fur family
I5S86_RS00300	COG1121	(ABC) transporter
I5S86_RS00305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5S86_RS00320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5S86_RS00325	COG2011	ABC-type metal ion transport system permease component
I5S86_RS00360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_RS00365	COG0765	amino acid transport
I5S86_RS00370	COG5016	pyruvate
I5S86_RS00370	COG0511	ligase activity, forming carbon-carbon bonds
I5S86_RS00375	COG0439	Biotin carboxylase
I5S86_RS00380	COG0583	DNA-binding transcription factor activity
I5S86_RS00390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5S86_RS00410	COG4651	solute:proton antiporter activity
I5S86_RS00410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5S86_RS00415	COG1607	acyl-coa hydrolase
I5S86_RS00420	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I5S86_RS00430	COG0523	cobalamin synthesis protein
I5S86_RS00450	COG1469	GTP cyclohydrolase I activity
I5S86_RS00460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5S86_RS00465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5S86_RS00470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5S86_RS00475	COG0640	Transcriptional regulator
I5S86_RS00480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5S86_RS00485	COG0798	PFAM Bile acid sodium symporter
I5S86_RS00490	COG0431	NADPH-dependent FMN reductase
I5S86_RS00495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5S86_RS00540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5S86_RS00565	COG0066	3-isopropylmalate dehydratase activity
I5S86_RS00570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I5S86_RS00575	COG1017	nitric oxide dioxygenase activity
I5S86_RS00575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5S86_RS00580	COG0840	transmembrane signaling receptor activity
I5S86_RS00610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5S86_RS00660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5S86_RS00665	COG1349	DNA-binding transcription factor activity
I5S86_RS00670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5S86_RS00675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I5S86_RS00680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I5S86_RS00685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I5S86_RS00690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I5S86_RS00695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5S86_RS00700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I5S86_RS00710	COG0356	it plays a direct role in the translocation of protons across the membrane
I5S86_RS00715	COG3312	ion transport
I5S86_RS00720	COG1475	DNA binding
I5S86_RS00725	COG1192	Involved in chromosome partitioning
I5S86_RS00730	COG0357	Ribosomal RNA small subunit methyltransferase G
I5S86_RS00735	COG0445	tRNA wobble uridine modification
I5S86_RS00740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I5S86_RS00745	COG0706	membrane insertase activity
I5S86_RS00750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5S86_RS00755	COG0594	ribonuclease P activity
I5S86_RS00760	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I5S86_RS00765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I5S86_RS00770	COG0592	DNA-directed DNA polymerase activity
I5S86_RS00775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5S86_RS00780	COG0187	DNA topoisomerase II activity
I5S86_RS00840	COG2194	sulfuric ester hydrolase activity
I5S86_RS00890	COG0463	Glycosyl transferase, family 2
I5S86_RS00980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I5S86_RS01055	COG1252	NADH dehydrogenase
I5S86_RS01075	COG0477	Major facilitator Superfamily
I5S86_RS01085	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I5S86_RS01090	COG0751	glycine-tRNA ligase activity
I5S86_RS01095	COG0752	glycyl-tRNA synthetase alpha subunit
I5S86_RS01100	COG2818	Glycosylase
I5S86_RS01115	COG0569	domain protein
I5S86_RS01120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5S86_RS01125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I5S86_RS01130	COG0242	peptide deformylase activity
I5S86_RS01135	COG3344	reverse transcriptase
I5S86_RS01140	COG0758	DNA mediated transformation
I5S86_RS01145	COG0009	L-threonylcarbamoyladenylate synthase
I5S86_RS01160	COG0408	coproporphyrinogen oxidase activity
I5S86_RS01165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5S86_RS01170	COG0659	secondary active sulfate transmembrane transporter activity
I5S86_RS01180	COG3119	arylsulfatase activity
I5S86_RS01200	COG0159	tryptophan synthase activity
I5S86_RS01205	COG0133	tryptophan synthase activity
I5S86_RS01220	COG3360	Dodecin
I5S86_RS01230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5S86_RS01235	COG1764	response to oxidative stress
I5S86_RS01265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5S86_RS01270	COG0339	signal peptide processing
I5S86_RS01275	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I5S86_RS01295	COG0659	secondary active sulfate transmembrane transporter activity
I5S86_RS01310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5S86_RS01315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5S86_RS01320	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I5S86_RS01345	COG1612	heme a metabolic process
I5S86_RS01350	COG0109	protoheme IX farnesyltransferase activity
I5S86_RS01380	COG1027	Aspartate ammonia-lyase
I5S86_RS01385	COG0583	DNA-binding transcription factor activity
I5S86_RS01420	COG1607	acyl-coa hydrolase
I5S86_RS01425	COG0477	Major facilitator Superfamily
I5S86_RS01440	COG0581	inorganic phosphate transmembrane transporter activity
I5S86_RS01445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5S86_RS01450	COG0704	Plays a role in the regulation of phosphate uptake
I5S86_RS01460	COG0739	heme binding
I5S86_RS01465	COG3657	addiction module killer protein
I5S86_RS01470	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5S86_RS01475	COG1253	flavin adenine dinucleotide binding
I5S86_RS01495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I5S86_RS01500	COG3161	chorismate lyase activity
I5S86_RS01530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5S86_RS01535	COG0583	DNA-binding transcription factor activity
I5S86_RS01545	COG0848	biopolymer transport protein
I5S86_RS01555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5S86_RS01570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5S86_RS01575	COG1758	RNA polymerase activity
I5S86_RS01585	COG0174	glutamine synthetase
I5S86_RS01590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5S86_RS01600	COG0194	GDP metabolic process
I5S86_RS01605	COG1561	YicC-like family, N-terminal region
I5S86_RS01610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I5S86_RS01615	COG0708	Exodeoxyribonuclease III
I5S86_RS01620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I5S86_RS01625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5S86_RS01630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5S86_RS01635	COG0756	dUTP diphosphatase activity
I5S86_RS01640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5S86_RS01645	COG2003	Belongs to the UPF0758 family
I5S86_RS01650	COG0747	negative chemotaxis
I5S86_RS01655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I5S86_RS01660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5S86_RS01675	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS01685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5S86_RS01690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_RS01700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS01715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS01735	COG0427	acetyl-CoA hydrolase
I5S86_RS01740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5S86_RS01755	COG0534	Mate efflux family protein
I5S86_RS01775	COG5383	Protein conserved in bacteria
I5S86_RS01780	COG0583	DNA-binding transcription factor activity
I5S86_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS01790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS01805	COG1335	isochorismatase
I5S86_RS01835	COG0583	DNA-binding transcription factor activity
I5S86_RS01855	COG0606	chelatase, subunit chli
I5S86_RS01900	COG1360	Flagellar Motor Protein
I5S86_RS01930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I5S86_RS01935	COG1677	Flagellar hook-basal body complex protein FliE
I5S86_RS01940	COG1766	The M ring may be actively involved in energy transduction
I5S86_RS01945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5S86_RS01960	COG2882	bacterial-type flagellum organization
I5S86_RS01975	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5S86_RS01995	COG1987	bacterial-type flagellum assembly
I5S86_RS02015	COG3951	Flagellar rod assembly protein muramidase FlgJ
I5S86_RS02015	COG1705	Flagellar rod assembly protein muramidase FlgJ
I5S86_RS02020	COG1706	bacterial-type flagellum-dependent cell motility
I5S86_RS02030	COG4786	Flagellar basal body rod
I5S86_RS02050	COG1558	bacterial-type flagellum-dependent cell motility
I5S86_RS02085	COG0347	Belongs to the P(II) protein family
I5S86_RS02090	COG0004	ammonium transporteR
I5S86_RS02100	COG0546	phosphoglycolate phosphatase activity
I5S86_RS02105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5S86_RS02115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I5S86_RS02120	COG0019	diaminopimelate decarboxylase activity
I5S86_RS02130	COG1965	Belongs to the frataxin family
I5S86_RS02140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5S86_RS02160	COG0625	glutathione transferase activity
I5S86_RS02165	COG0165	Argininosuccinate lyase
I5S86_RS02175	COG0181	hydroxymethylbilane synthase activity
I5S86_RS02195	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I5S86_RS02220	COG0488	(ABC) transporter
I5S86_RS02225	COG1280	lysine exporter protein (LysE YggA)
I5S86_RS02255	COG0517	IMP dehydrogenase activity
I5S86_RS02285	COG1522	sequence-specific DNA binding
I5S86_RS02300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5S86_RS02300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I5S86_RS02305	COG0174	glutamine synthetase
I5S86_RS02310	COG0174	glutamine synthetase
I5S86_RS02330	COG3842	ATPase activity
I5S86_RS02335	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5S86_RS02340	COG1177	transmembrane transport
I5S86_RS02355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_RS02365	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I5S86_RS02375	COG4208	sulfate ABC transporter
I5S86_RS02380	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I5S86_RS02435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_RS02445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5S86_RS02450	COG0277	FAD linked oxidase domain protein
I5S86_RS02455	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5S86_RS02460	COG3204	pilus organization
I5S86_RS02465	COG3204	pilus organization
I5S86_RS02470	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I5S86_RS02475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5S86_RS02490	COG0494	nUDIX hydrolase
I5S86_RS02495	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I5S86_RS02505	COG0730	response to heat
I5S86_RS02510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I5S86_RS02515	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I5S86_RS02520	COG0789	Transcriptional regulator
I5S86_RS02530	COG0583	DNA-binding transcription factor activity
I5S86_RS02535	COG3842	ATPase activity
I5S86_RS02540	COG1178	ABC-type Fe3 transport system permease component
I5S86_RS02545	COG1840	ABC-type Fe3 transport system, periplasmic component
I5S86_RS02550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I5S86_RS02565	COG1823	symporter activity
I5S86_RS02575	COG0129	dihydroxy-acid dehydratase activity
I5S86_RS02580	COG2239	Acts as a magnesium transporter
I5S86_RS02585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5S86_RS02595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I5S86_RS02600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5S86_RS02605	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I5S86_RS02610	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I5S86_RS02645	COG0612	Peptidase, M16
I5S86_RS02650	COG0742	ribosomal rna small subunit methyltransferase
I5S86_RS02655	COG0612	Peptidase, M16
I5S86_RS02660	COG0612	Peptidase, M16
I5S86_RS02665	COG0552	protein localization to endoplasmic reticulum
I5S86_RS02670	COG2884	Cell division ATP-binding protein ftsE
I5S86_RS02675	COG2177	Part of the ABC transporter FtsEX involved in
I5S86_RS02685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5S86_RS02690	COG2363	Small membrane protein
I5S86_RS02700	COG2022	thiamine diphosphate biosynthetic process
I5S86_RS02705	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5S86_RS02715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5S86_RS02720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I5S86_RS02730	COG2813	Specifically methylates the guanine in position
I5S86_RS02730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5S86_RS02735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5S86_RS02760	COG0791	NLP P60 protein
I5S86_RS02775	COG0018	arginyl-trna synthetase
I5S86_RS02780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5S86_RS02785	COG0254	rRNA binding
I5S86_RS02795	COG0281	malic enzyme
I5S86_RS02825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5S86_RS02830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I5S86_RS02840	COG0069	glutamate synthase activity
I5S86_RS02840	COG0070	glutamate synthase
I5S86_RS02840	COG0067	glutamate synthase
I5S86_RS02845	COG0493	'glutamate synthase
I5S86_RS02850	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I5S86_RS02860	COG2814	Major facilitator Superfamily
I5S86_RS02865	COG0583	DNA-binding transcription factor activity
I5S86_RS02870	COG1192	Involved in chromosome partitioning
I5S86_RS02885	COG3118	belongs to the thioredoxin family
I5S86_RS02890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I5S86_RS02895	COG1196	nuclear chromosome segregation
I5S86_RS02895	COG3264	Mechanosensitive ion channel
I5S86_RS02900	COG3263	regulation of cellular component size
I5S86_RS02905	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I5S86_RS02910	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS02915	COG1309	transcriptional regulator
I5S86_RS02920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5S86_RS02930	COG2861	carbohydrate metabolic process
I5S86_RS02935	COG0793	Belongs to the peptidase S41A family
I5S86_RS02940	COG4942	peptidase
I5S86_RS02945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I5S86_RS02950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5S86_RS02960	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I5S86_RS02965	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5S86_RS02980	COG3852	Histidine kinase
I5S86_RS02990	COG0301	tRNA thio-modification
I5S86_RS02990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5S86_RS02995	COG1217	gtp-binding protein TYPA
I5S86_RS03005	COG0058	SHG alpha-glucan phosphorylase activity
I5S86_RS03010	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I5S86_RS03035	COG0402	S-adenosylhomocysteine deaminase activity
I5S86_RS03040	COG2188	Transcriptional regulator
I5S86_RS03050	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I5S86_RS03055	COG2986	histidine ammonia-lyase
I5S86_RS03065	COG1228	amidohydrolase
I5S86_RS03085	COG1490	D-aminoacyl-tRNA deacylase activity
I5S86_RS03090	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I5S86_RS03095	COG2943	transferase activity, transferring hexosyl groups
I5S86_RS03105	COG0765	amino acid transport
I5S86_RS03110	COG1126	abc transporter atp-binding protein
I5S86_RS03115	COG0840	transmembrane signaling receptor activity
I5S86_RS03120	COG0840	transmembrane signaling receptor activity
I5S86_RS03140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5S86_RS03145	COG0140	phosphoribosyl-ATP diphosphatase activity
I5S86_RS03150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I5S86_RS03155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I5S86_RS03165	COG2226	methyltransferase
I5S86_RS03210	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I5S86_RS03215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I5S86_RS03220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5S86_RS03225	COG0540	Belongs to the ATCase OTCase family
I5S86_RS03230	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I5S86_RS03235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I5S86_RS03240	COG1678	Uncharacterized ACR, COG1678
I5S86_RS03250	COG0189	ligase activity
I5S86_RS03275	COG0643	Histidine kinase
I5S86_RS03275	COG2198	Histidine kinase
I5S86_RS03275	COG0784	Response regulator, receiver
I5S86_RS03285	COG1272	protein, Hemolysin III
I5S86_RS03290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5S86_RS03310	COG3038	cytochrome b561
I5S86_RS03315	COG2353	YceI-like domain
I5S86_RS03320	COG0513	Belongs to the DEAD box helicase family
I5S86_RS03335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I5S86_RS03340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I5S86_RS03380	COG1422	Protein of unknown function (DUF1090)
I5S86_RS03385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I5S86_RS03390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I5S86_RS03395	COG0640	Transcriptional regulator
I5S86_RS03405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5S86_RS03410	COG0126	phosphoglycerate kinase activity
I5S86_RS03430	COG3300	MHYT domain
I5S86_RS03430	COG5001	Diguanylate cyclase
I5S86_RS03435	COG1451	nucleotide metabolic process
I5S86_RS03450	COG1289	transmembrane transporter activity
I5S86_RS03455	COG2081	HI0933 family
I5S86_RS03460	COG0513	Belongs to the DEAD box helicase family
I5S86_RS03465	COG0477	Major facilitator Superfamily
I5S86_RS03470	COG0312	modulator of DNA gyrase
I5S86_RS03480	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS03505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5S86_RS03510	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I5S86_RS03515	COG2192	nodulation
I5S86_RS03520	COG0438	transferase activity, transferring glycosyl groups
I5S86_RS03550	COG1132	(ABC) transporter
I5S86_RS03555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I5S86_RS03555	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I5S86_RS03565	COG0667	Aldo Keto reductase
I5S86_RS03585	COG1519	Transferase
I5S86_RS03590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_RS03600	COG0730	response to heat
I5S86_RS03605	COG4221	oxidoreductase activity
I5S86_RS03610	COG0243	molybdopterin cofactor binding
I5S86_RS03610	COG3383	formate dehydrogenase (NAD+) activity
I5S86_RS03615	COG0243	molybdopterin cofactor binding
I5S86_RS03615	COG3383	formate dehydrogenase (NAD+) activity
I5S86_RS03620	COG0437	4 iron, 4 sulfur cluster binding
I5S86_RS03625	COG2864	formate dehydrogenase
I5S86_RS03630	COG3058	Necessary for formate dehydrogenase activity
I5S86_RS03635	COG1921	L-seryl-tRNASec selenium transferase activity
I5S86_RS03640	COG3276	selenocysteine insertion sequence binding
I5S86_RS03650	COG0252	asparaginase activity
I5S86_RS03655	COG1115	amino acid carrier protein
I5S86_RS03670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5S86_RS03675	COG3047	cAMP biosynthetic process
I5S86_RS03690	COG0577	efflux transmembrane transporter activity
I5S86_RS03690	COG1136	(ABC) transporter
I5S86_RS03705	COG3118	belongs to the thioredoxin family
I5S86_RS03710	COG2264	protein methyltransferase activity
I5S86_RS03720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5S86_RS03725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5S86_RS03725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5S86_RS03740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I5S86_RS03745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5S86_RS03750	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I5S86_RS03755	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5S86_RS03765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5S86_RS03775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5S86_RS03780	COG4206	TonB-dependent receptor
I5S86_RS03785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I5S86_RS03790	COG0142	geranyltranstransferase activity
I5S86_RS03795	COG1722	exodeoxyribonuclease VII activity
I5S86_RS03800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5S86_RS03805	COG2819	hydrolase of the alpha beta superfamily
I5S86_RS03850	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I5S86_RS03855	COG3228	Belongs to the MtfA family
I5S86_RS03860	COG0586	Pfam SNARE associated Golgi protein
I5S86_RS03865	COG0456	acetyltransferase
I5S86_RS03870	COG4302	ethanolamine ammonia-lyase activity
I5S86_RS03875	COG4303	Ethanolamine ammonia lyase large subunit
I5S86_RS03880	COG0531	amino acid
I5S86_RS03890	COG3284	Transcriptional regulator
I5S86_RS03895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5S86_RS03910	COG0702	epimerase
I5S86_RS03930	COG1346	cytolysis
I5S86_RS03940	COG0586	Pfam SNARE associated Golgi protein
I5S86_RS03945	COG2094	Belongs to the DNA glycosylase MPG family
I5S86_RS03950	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I5S86_RS03955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I5S86_RS03965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I5S86_RS03970	COG0768	penicillin binding
I5S86_RS03975	COG0772	Belongs to the SEDS family
I5S86_RS03980	COG2951	lytic endotransglycosylase activity
I5S86_RS03990	COG1686	Belongs to the peptidase S11 family
I5S86_RS03995	COG2921	Belongs to the UPF0250 family
I5S86_RS04000	COG0321	lipoyl(octanoyl) transferase activity
I5S86_RS04005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I5S86_RS04010	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5S86_RS04015	COG2951	lytic endotransglycosylase activity
I5S86_RS04035	COG0495	leucyl-tRNA aminoacylation
I5S86_RS04050	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I5S86_RS04055	COG4535	Mg2 and Co2 transporter CorC
I5S86_RS04060	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I5S86_RS04065	COG1702	phosphate starvation-inducible protein PhoH
I5S86_RS04080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5S86_RS04085	COG0352	thiamine-phosphate diphosphorylase activity
I5S86_RS04090	COG0351	phosphomethylpyrimidine kinase
I5S86_RS04095	COG4999	Histidine kinase
I5S86_RS04095	COG3437	response regulator, receiver
I5S86_RS04095	COG2205	protein histidine kinase activity
I5S86_RS04095	COG3850	Histidine kinase
I5S86_RS04100	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS04105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5S86_RS04120	COG1522	sequence-specific DNA binding
I5S86_RS04165	COG0515	serine threonine protein kinase
I5S86_RS04165	COG2815	serine threonine protein kinase
I5S86_RS04170	COG1643	Atp-dependent helicase
I5S86_RS04180	COG3416	Protein conserved in bacteria
I5S86_RS04190	COG0697	spore germination
I5S86_RS04195	COG0513	Belongs to the DEAD box helicase family
I5S86_RS04205	COG0123	including yeast histone deacetylase and acetoin utilization protein
I5S86_RS04215	COG1946	Acyl-CoA thioesterase
I5S86_RS04220	COG0546	phosphoglycolate phosphatase activity
I5S86_RS04225	COG1064	alcohol dehydrogenase
I5S86_RS04230	COG1609	Transcriptional regulator
I5S86_RS04245	COG0583	DNA-binding transcription factor activity
I5S86_RS04250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5S86_RS04255	COG2271	Major facilitator Superfamily
I5S86_RS04310	COG0529	Catalyzes the synthesis of activated sulfate
I5S86_RS04355	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I5S86_RS04370	COG0582	viral genome integration into host DNA
I5S86_RS04410	COG1304	FMN binding
I5S86_RS04415	COG1620	l-lactate permease
I5S86_RS04425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I5S86_RS04440	COG0735	belongs to the Fur family
I5S86_RS04445	COG0497	DNA recombination
I5S86_RS04450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I5S86_RS04455	COG0443	Heat shock 70 kDa protein
I5S86_RS04460	COG0484	heat shock protein binding
I5S86_RS04465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I5S86_RS04470	COG0505	Belongs to the CarA family
I5S86_RS04475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I5S86_RS04480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5S86_RS04495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I5S86_RS04505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5S86_RS04510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5S86_RS04515	COG0149	triose-phosphate isomerase activity
I5S86_RS04520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5S86_RS04535	COG0779	Required for maturation of 30S ribosomal subunits
I5S86_RS04540	COG0195	Participates in both transcription termination and antitermination
I5S86_RS04545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I5S86_RS04550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I5S86_RS04555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I5S86_RS04560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I5S86_RS04565	COG1185	polyribonucleotide nucleotidyltransferase activity
I5S86_RS04570	COG2823	Periplasmic or secreted lipoprotein
I5S86_RS04595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5S86_RS04600	COG0166	Belongs to the GPI family
I5S86_RS04605	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I5S86_RS04610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I5S86_RS04620	COG0617	tRNA 3'-terminal CCA addition
I5S86_RS04625	COG2204	response regulator
I5S86_RS04630	COG4191	Histidine kinase
I5S86_RS04640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5S86_RS04650	COG0436	Aminotransferase
I5S86_RS04655	COG1489	DNA binding
I5S86_RS04665	COG4558	Periplasmic binding protein
I5S86_RS04670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5S86_RS04675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I5S86_RS04695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5S86_RS04705	COG3098	single-species biofilm formation
I5S86_RS04710	COG0028	Belongs to the TPP enzyme family
I5S86_RS04720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I5S86_RS04725	COG1183	phosphatidylcholine synthase activity
I5S86_RS04730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I5S86_RS04735	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I5S86_RS04765	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I5S86_RS04770	COG1074	ATP-dependent DNA helicase activity
I5S86_RS04775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5S86_RS04815	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5S86_RS04820	COG0583	DNA-binding transcription factor activity
I5S86_RS04830	COG0840	transmembrane signaling receptor activity
I5S86_RS04835	COG2321	neutral zinc metallopeptidase
I5S86_RS04840	COG3485	protocatechuate 3,4-dioxygenase
I5S86_RS04845	COG3485	protocatechuate 3,4-dioxygenase
I5S86_RS04850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5S86_RS04855	COG2252	PERMEase
I5S86_RS04865	COG1271	oxidase subunit
I5S86_RS04870	COG1294	oxidase, subunit
I5S86_RS04880	COG2813	Specifically methylates the guanine in position
I5S86_RS04885	COG2197	response regulator
I5S86_RS04895	COG1970	mechanosensitive ion channel activity
I5S86_RS04905	COG2233	PERMEase
I5S86_RS04915	COG3397	chitin binding
I5S86_RS04920	COG1966	Carbon starvation protein
I5S86_RS04925	COG2879	small protein
I5S86_RS04930	COG0523	cobalamin synthesis protein
I5S86_RS04940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5S86_RS04950	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I5S86_RS04980	COG0789	Transcriptional regulator
I5S86_RS04990	COG1366	Belongs to the anti-sigma-factor antagonist family
I5S86_RS05005	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS05015	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I5S86_RS05035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5S86_RS05090	COG4977	sequence-specific DNA binding
I5S86_RS05125	COG2233	PERMEase
I5S86_RS05210	COG3039	Transposase
I5S86_RS05285	COG4964	Belongs to the GSP D family
I5S86_RS05340	COG3708	Transcriptional regulator
I5S86_RS05340	COG2207	Transcriptional regulator
I5S86_RS05355	COG2246	polysaccharide biosynthetic process
I5S86_RS05365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5S86_RS05370	COG0583	DNA-binding transcription factor activity
I5S86_RS05390	COG1566	PFAM secretion protein HlyD family protein
I5S86_RS05425	COG0300	oxidoreductase activity
I5S86_RS05435	COG0662	Cupin 2, conserved barrel domain protein
I5S86_RS05435	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I5S86_RS05450	COG1696	Membrane protein involved in D-alanine export
I5S86_RS05465	COG3420	alginic acid biosynthetic process
I5S86_RS05475	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I5S86_RS05480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_RS05485	COG1215	transferase activity, transferring glycosyl groups
I5S86_RS05490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I5S86_RS05510	COG1136	(ABC) transporter
I5S86_RS05515	COG0577	efflux transmembrane transporter activity
I5S86_RS05515	COG1136	(ABC) transporter
I5S86_RS05530	COG3022	response to hydroperoxide
I5S86_RS05540	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I5S86_RS05545	COG0315	cyclic pyranopterin monophosphate synthase activity
I5S86_RS05550	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I5S86_RS05560	COG0513	Belongs to the DEAD box helicase family
I5S86_RS05565	COG0400	carboxylic ester hydrolase activity
I5S86_RS05570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_RS05575	COG4597	amino acid ABC transporter
I5S86_RS05580	COG0765	amino acid transport
I5S86_RS05585	COG1126	abc transporter atp-binding protein
I5S86_RS05590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5S86_RS05600	COG0175	sulfate reduction
I5S86_RS05625	COG1522	sequence-specific DNA binding
I5S86_RS05645	COG0180	Tryptophanyl-tRNA synthetase
I5S86_RS05650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5S86_RS05660	COG0667	Aldo Keto reductase
I5S86_RS05665	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I5S86_RS05670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I5S86_RS05675	COG0723	plastoquinol--plastocyanin reductase activity
I5S86_RS05680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I5S86_RS05685	COG2857	Cytochrome c1
I5S86_RS05690	COG0625	glutathione transferase activity
I5S86_RS05695	COG2969	positive regulation of protein catabolic process
I5S86_RS05705	COG2823	Periplasmic or secreted lipoprotein
I5S86_RS05710	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I5S86_RS05715	COG0792	nuclease activity
I5S86_RS05720	COG3107	peptidoglycan biosynthetic process
I5S86_RS05735	COG2001	Belongs to the MraZ family
I5S86_RS05740	COG0275	rRNA processing
I5S86_RS05755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5S86_RS05760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5S86_RS05765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5S86_RS05770	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I5S86_RS05775	COG0772	Belongs to the SEDS family
I5S86_RS05780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5S86_RS05785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5S86_RS05790	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5S86_RS05805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5S86_RS05810	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I5S86_RS05820	COG0653	protein targeting
I5S86_RS05825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I5S86_RS05835	COG0494	nUDIX hydrolase
I5S86_RS05840	COG2096	Adenosyltransferase
I5S86_RS05845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_RS05845	COG4191	Histidine kinase
I5S86_RS05855	COG1666	GTP binding
I5S86_RS05860	COG0668	transmembrane transport
I5S86_RS05870	COG2211	Major facilitator Superfamily
I5S86_RS05890	COG3030	protein affecting phage T7 exclusion by the F plasmid
I5S86_RS05895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I5S86_RS05900	COG0459	protein refolding
I5S86_RS05910	COG0642	Histidine kinase
I5S86_RS05920	COG3642	lipopolysaccharide core region biosynthetic process
I5S86_RS05930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_RS05935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_RS05965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5S86_RS05975	COG0583	DNA-binding transcription factor activity
I5S86_RS05980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5S86_RS05990	COG1902	pentaerythritol trinitrate reductase activity
I5S86_RS06035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5S86_RS06040	COG0693	protein deglycase activity
I5S86_RS06075	COG2925	Exonuclease
I5S86_RS06085	COG0788	formyltetrahydrofolate deformylase activity
I5S86_RS06100	COG0438	transferase activity, transferring glycosyl groups
I5S86_RS06100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5S86_RS06105	COG0840	transmembrane signaling receptor activity
I5S86_RS06110	COG0433	COG0433 Predicted ATPase
I5S86_RS06115	COG0306	phosphate transporter
I5S86_RS06125	COG1414	Transcriptional regulator
I5S86_RS06130	COG2814	Major facilitator Superfamily
I5S86_RS06135	COG0183	Belongs to the thiolase family
I5S86_RS06140	COG0477	Major facilitator Superfamily
I5S86_RS06145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5S86_RS06150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5S86_RS06155	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5S86_RS06175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_RS06180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_RS06185	COG1309	transcriptional regulator
I5S86_RS06190	COG0477	Major facilitator Superfamily
I5S86_RS06195	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5S86_RS06205	COG0583	DNA-binding transcription factor activity
I5S86_RS06215	COG2910	NAD(P)H-binding
I5S86_RS06220	COG0583	DNA-binding transcription factor activity
I5S86_RS06230	COG2207	Transcriptional regulator
I5S86_RS06255	COG0477	Major facilitator Superfamily
I5S86_RS06265	COG4191	Histidine kinase
I5S86_RS06290	COG0584	glycerophosphoryl diester phosphodiesterase
I5S86_RS06300	COG2267	carboxylic ester hydrolase activity
I5S86_RS06325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I5S86_RS06370	COG0354	folic acid binding
I5S86_RS06375	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I5S86_RS06405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5S86_RS06410	COG0481	GTPase activity
I5S86_RS06415	COG0681	Belongs to the peptidase S26 family
I5S86_RS06420	COG0571	ribonuclease III activity
I5S86_RS06425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I5S86_RS06430	COG1381	Involved in DNA repair and RecF pathway recombination
I5S86_RS06435	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I5S86_RS06440	COG0500	methyltransferase
I5S86_RS06445	COG2226	methyltransferase
I5S86_RS06455	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5S86_RS06470	COG4206	TonB-dependent receptor
I5S86_RS06475	COG4628	conserved protein (DUF2132)
I5S86_RS06485	COG2375	cellular response to nickel ion
I5S86_RS06490	COG1695	Transcriptional regulator
I5S86_RS06500	COG1113	amino acid transport
I5S86_RS06505	COG0069	glutamate synthase activity
I5S86_RS06510	COG1201	RNA secondary structure unwinding
I5S86_RS06515	COG0494	nUDIX hydrolase
I5S86_RS06520	COG0583	DNA-binding transcription factor activity
I5S86_RS06525	COG2267	carboxylic ester hydrolase activity
I5S86_RS06540	COG1126	abc transporter atp-binding protein
I5S86_RS06545	COG0765	amino acid transport
I5S86_RS06550	COG0765	amino acid transport
I5S86_RS06575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5S86_RS06585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5S86_RS06590	COG3842	ATPase activity
I5S86_RS06595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I5S86_RS06600	COG0243	molybdopterin cofactor binding
I5S86_RS06605	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I5S86_RS06620	COG0450	alkyl hydroperoxide reductase
I5S86_RS06625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5S86_RS06630	COG0418	dihydroorotase activity
I5S86_RS06640	COG0137	argininosuccinate synthase activity
I5S86_RS06650	COG2197	response regulator
I5S86_RS06660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5S86_RS06665	COG4660	Part of a membrane complex involved in electron transport
I5S86_RS06670	COG4659	FMN binding
I5S86_RS06685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5S86_RS06685	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5S86_RS06690	COG0489	protein tyrosine kinase activity
I5S86_RS06695	COG1278	Cold shock
I5S86_RS06700	COG0717	Belongs to the dCTP deaminase family
I5S86_RS06715	COG1201	RNA secondary structure unwinding
I5S86_RS06725	COG1793	dna ligase
I5S86_RS06730	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5S86_RS06730	COG1793	dna ligase
I5S86_RS06740	COG2366	antibiotic biosynthetic process
I5S86_RS06745	COG0653	protein targeting
I5S86_RS06755	COG3012	SEC-C Motif Domain Protein
I5S86_RS06785	COG1199	ATP-dependent helicase activity
I5S86_RS06800	COG2885	chlorophyll binding
I5S86_RS06805	COG0259	pyridoxamine-phosphate oxidase activity
I5S86_RS06815	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I5S86_RS06855	COG2084	Dehydrogenase
I5S86_RS06865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5S86_RS06885	COG1289	transmembrane transporter activity
I5S86_RS06895	COG1566	PFAM secretion protein HlyD family protein
I5S86_RS06910	COG3706	GGDEF domain
I5S86_RS06915	COG2116	formate transmembrane transporter activity
I5S86_RS06940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5S86_RS06950	COG0252	asparaginase activity
I5S86_RS06960	COG0625	glutathione transferase activity
I5S86_RS06995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I5S86_RS07005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5S86_RS07035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5S86_RS07040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5S86_RS07040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5S86_RS07045	COG0745	RESPONSE REGULATOR receiver
I5S86_RS07050	COG2205	protein histidine kinase activity
I5S86_RS07080	COG1301	dicarboxylic acid transport
I5S86_RS07085	COG3091	SprT-like family
I5S86_RS07095	COG0037	tRNA processing
I5S86_RS07135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5S86_RS07140	COG5002	protein histidine kinase activity
I5S86_RS07140	COG2205	protein histidine kinase activity
I5S86_RS07140	COG0784	Response regulator, receiver
I5S86_RS07160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5S86_RS07165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5S86_RS07170	COG3956	TIGRFAM MazG family protein
I5S86_RS07175	COG3122	Protein conserved in bacteria
I5S86_RS07190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5S86_RS07195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I5S86_RS07205	COG0628	permease
I5S86_RS07215	COG0791	NLP P60 protein
I5S86_RS07220	COG0791	NLP P60 protein
I5S86_RS07230	COG1797	cobyrinic acid a,c-diamide synthase activity
I5S86_RS07235	COG0778	Nitroreductase
I5S86_RS07240	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I5S86_RS07250	COG1492	cobalamin metabolic process
I5S86_RS07260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I5S86_RS07265	COG0406	alpha-ribazole phosphatase activity
I5S86_RS07270	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I5S86_RS07275	COG1846	Transcriptional regulator
I5S86_RS07315	COG2205	protein histidine kinase activity
I5S86_RS07320	COG2188	Transcriptional regulator
I5S86_RS07335	COG0840	transmembrane signaling receptor activity
I5S86_RS07345	COG2076	Multidrug Resistance protein
I5S86_RS07350	COG2974	May be involved in recombination
I5S86_RS07375	COG0024	Methionine aminopeptidase
I5S86_RS07380	COG0243	molybdopterin cofactor binding
I5S86_RS07385	COG2146	nitrite reductase [NAD(P)H] activity
I5S86_RS07385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5S86_RS07390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5S86_RS07390	COG2146	nitrite reductase [NAD(P)H] activity
I5S86_RS07395	COG0583	DNA-binding transcription factor activity
I5S86_RS07405	COG0545	Peptidyl-prolyl cis-trans isomerase
I5S86_RS07410	COG3339	Conserved Protein
I5S86_RS07450	COG0395	ABC-type sugar transport system, permease component
I5S86_RS07470	COG0668	transmembrane transport
I5S86_RS07490	COG1362	aminopeptidase activity
I5S86_RS07495	COG0564	pseudouridine synthase activity
I5S86_RS07500	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I5S86_RS07505	COG2894	cell division
I5S86_RS07510	COG0850	regulation of cytokinetic process
I5S86_RS07515	COG1560	Kdo2-lipid A biosynthetic process
I5S86_RS07525	COG2853	Lipoprotein
I5S86_RS07545	COG2113	Glycine betaine
I5S86_RS07550	COG3162	membrane
I5S86_RS07555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5S86_RS07580	COG2197	response regulator
I5S86_RS07585	COG2205	protein histidine kinase activity
I5S86_RS07585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_RS07590	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS07595	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5S86_RS07600	COG3089	Belongs to the UPF0270 family
I5S86_RS07605	COG1363	Peptidase, m42
I5S86_RS07610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5S86_RS07610	COG0189	ligase activity
I5S86_RS07615	COG0367	asparagine synthase
I5S86_RS07620	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I5S86_RS07620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS07625	COG2326	polyphosphate kinase activity
I5S86_RS07630	COG0697	spore germination
I5S86_RS07635	COG0114	fumarate hydratase activity
I5S86_RS07645	COG0271	Belongs to the BolA IbaG family
I5S86_RS07650	COG1054	Belongs to the UPF0176 family
I5S86_RS07665	COG5001	Diguanylate cyclase
I5S86_RS07665	COG5002	protein histidine kinase activity
I5S86_RS07675	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS07685	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS07690	COG0546	phosphoglycolate phosphatase activity
I5S86_RS07695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5S86_RS07700	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I5S86_RS07710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I5S86_RS07720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I5S86_RS07725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I5S86_RS07735	COG0776	regulation of translation
I5S86_RS07745	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5S86_RS07755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5S86_RS07770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5S86_RS07790	COG1091	dTDP-4-dehydrorhamnose reductase activity
I5S86_RS07825	COG1216	Glycosyl transferase, family 2
I5S86_RS07825	COG0438	transferase activity, transferring glycosyl groups
I5S86_RS07850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_RS07855	COG1538	Outer membrane efflux protein
I5S86_RS07860	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I5S86_RS07870	COG0438	transferase activity, transferring glycosyl groups
I5S86_RS07885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5S86_RS07895	COG1555	photosystem II stabilization
I5S86_RS07905	COG0284	orotidine-5'-phosphate decarboxylase activity
I5S86_RS07915	COG1215	transferase activity, transferring glycosyl groups
I5S86_RS07930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I5S86_RS07940	COG2130	NADP-dependent
I5S86_RS07945	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS07955	COG0840	transmembrane signaling receptor activity
I5S86_RS07960	COG3135	benzoate transporter
I5S86_RS07965	COG0625	glutathione transferase activity
I5S86_RS07975	COG0302	gtp cyclohydrolase
I5S86_RS08010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I5S86_RS08015	COG2814	Major facilitator Superfamily
I5S86_RS08020	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I5S86_RS08050	COG1368	sulfuric ester hydrolase activity
I5S86_RS08070	COG0519	Catalyzes the synthesis of GMP from XMP
I5S86_RS08075	COG0598	Magnesium transport protein CorA
I5S86_RS08080	COG0204	Acyl-transferase
I5S86_RS08130	COG2814	Major facilitator Superfamily
I5S86_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS08140	COG0583	DNA-binding transcription factor activity
I5S86_RS08175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I5S86_RS08180	COG1764	response to oxidative stress
I5S86_RS08185	COG1846	Transcriptional regulator
I5S86_RS08190	COG0583	DNA-binding transcription factor activity
I5S86_RS08200	COG0583	DNA-binding transcription factor activity
I5S86_RS08210	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I5S86_RS08225	COG3384	dioxygenase
I5S86_RS08230	COG0500	methyltransferase
I5S86_RS08235	COG0501	Belongs to the peptidase M48B family
I5S86_RS08240	COG0436	Aminotransferase
I5S86_RS08245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5S86_RS08250	COG0386	Belongs to the glutathione peroxidase family
I5S86_RS08255	COG0784	Response regulator, receiver
I5S86_RS08255	COG2205	protein histidine kinase activity
I5S86_RS08255	COG5002	protein histidine kinase activity
I5S86_RS08265	COG1956	GAF domain-containing protein
I5S86_RS08385	COG0625	glutathione transferase activity
I5S86_RS08390	COG1131	(ABC) transporter
I5S86_RS08395	COG0842	Transport permease protein
I5S86_RS08405	COG2333	competence protein COMEC
I5S86_RS08405	COG0658	competence protein
I5S86_RS08410	COG0811	peptide transport
I5S86_RS08415	COG0848	biopolymer transport protein
I5S86_RS08420	COG1663	tetraacyldisaccharide 4'-kinase activity
I5S86_RS08425	COG2835	tetraacyldisaccharide 4'-kinase activity
I5S86_RS08430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I5S86_RS08435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5S86_RS08440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5S86_RS08445	COG1530	ribonuclease E activity
I5S86_RS08455	COG0546	phosphoglycolate phosphatase activity
I5S86_RS08460	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5S86_RS08460	COG0616	signal peptide processing
I5S86_RS08465	COG0424	maF-like protein
I5S86_RS08475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I5S86_RS08480	COG0416	fatty acid biosynthetic process
I5S86_RS08495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5S86_RS08500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5S86_RS08510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5S86_RS08515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I5S86_RS08525	COG0084	hydrolase, TatD family'
I5S86_RS08530	COG1104	cysteine desulfurase activity
I5S86_RS08565	COG0556	nucleotide-excision repair
I5S86_RS08570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5S86_RS08610	COG0596	Alpha beta hydrolase
I5S86_RS08620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5S86_RS08640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I5S86_RS08645	COG0066	3-isopropylmalate dehydratase activity
I5S86_RS08650	COG2226	methyltransferase
I5S86_RS08655	COG0473	3-isopropylmalate dehydrogenase activity
I5S86_RS08680	COG0135	phosphoribosylanthranilate isomerase activity
I5S86_RS08685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I5S86_RS08690	COG0285	dihydrofolate synthase activity
I5S86_RS08700	COG1286	toxin biosynthetic process
I5S86_RS08760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5S86_RS08775	COG2358	TRAP transporter, solute receptor (TAXI family
I5S86_RS08780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5S86_RS08785	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5S86_RS08785	COG1902	pentaerythritol trinitrate reductase activity
I5S86_RS08795	COG3038	cytochrome b561
I5S86_RS08805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I5S86_RS08810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5S86_RS08820	COG3139	Protein of unknown function (DUF1315)
I5S86_RS08830	COG0308	aminopeptidase N
I5S86_RS08850	COG2706	6-phosphogluconolactonase activity
I5S86_RS08865	COG0420	3'-5' exonuclease activity
I5S86_RS08900	COG0714	Associated with various cellular activities
I5S86_RS08920	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I5S86_RS08935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5S86_RS08950	COG0668	transmembrane transport
I5S86_RS08970	COG2815	serine threonine protein kinase
I5S86_RS08970	COG0515	serine threonine protein kinase
I5S86_RS08975	COG2223	nitrite transmembrane transporter activity
I5S86_RS08980	COG3707	response regulator
I5S86_RS08985	COG1116	anion transmembrane transporter activity
I5S86_RS08985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5S86_RS08990	COG0167	dihydroorotate dehydrogenase activity
I5S86_RS08995	COG3130	regulation of translation
I5S86_RS09000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5S86_RS09000	COG0116	Belongs to the methyltransferase superfamily
I5S86_RS09010	COG2027	D-alanyl-D-alanine carboxypeptidase
I5S86_RS09015	COG3171	Protein conserved in bacteria
I5S86_RS09020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_RS09020	COG2205	protein histidine kinase activity
I5S86_RS09025	COG2197	response regulator
I5S86_RS09050	COG0004	ammonium transporteR
I5S86_RS09075	COG0840	transmembrane signaling receptor activity
I5S86_RS09085	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I5S86_RS09090	COG0425	Belongs to the sulfur carrier protein TusA family
I5S86_RS09095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5S86_RS09125	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5S86_RS09140	COG1597	lipid kinase activity
I5S86_RS09145	COG2197	response regulator
I5S86_RS09150	COG3851	Histidine kinase
I5S86_RS09160	COG0784	Response regulator, receiver
I5S86_RS09160	COG0835	chemotaxis
I5S86_RS09170	COG0741	lytic transglycosylase activity
I5S86_RS09175	COG0488	(ABC) transporter
I5S86_RS09180	COG0589	response to stress
I5S86_RS09190	COG1024	Enoyl-CoA hydratase
I5S86_RS09190	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5S86_RS09195	COG0183	Belongs to the thiolase family
I5S86_RS09225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5S86_RS09245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5S86_RS09255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5S86_RS09265	COG1477	protein flavinylation
I5S86_RS09270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5S86_RS09275	COG0584	glycerophosphoryl diester phosphodiesterase
I5S86_RS09285	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5S86_RS09290	COG1136	(ABC) transporter
I5S86_RS09295	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5S86_RS09315	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I5S86_RS09315	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I5S86_RS09330	COG2853	Lipoprotein
I5S86_RS09340	COG4566	intracellular signal transduction
I5S86_RS09355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5S86_RS09360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5S86_RS09370	COG2271	Major facilitator Superfamily
I5S86_RS09385	COG3766	membrane
I5S86_RS09395	COG0754	glutathionylspermidine amidase activity
I5S86_RS09410	COG3383	formate dehydrogenase (NAD+) activity
I5S86_RS09420	COG4178	(ABC) transporter
I5S86_RS09425	COG2135	peptidase activity
I5S86_RS09445	COG2132	Multicopper oxidase
I5S86_RS09450	COG1230	cation diffusion facilitator family transporter
I5S86_RS09490	COG0730	response to heat
I5S86_RS09495	COG0840	transmembrane signaling receptor activity
I5S86_RS09500	COG0583	DNA-binding transcription factor activity
I5S86_RS09520	COG2186	Transcriptional regulator
I5S86_RS09535	COG2423	ornithine cyclodeaminase activity
I5S86_RS09540	COG3284	Transcriptional regulator
I5S86_RS09545	COG3842	ATPase activity
I5S86_RS09560	COG0395	ABC-type sugar transport system, permease component
I5S86_RS09575	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5S86_RS09605	COG0544	peptidyl-prolyl cis-trans isomerase activity
I5S86_RS09610	COG0740	serine-type endopeptidase activity
I5S86_RS09615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I5S86_RS09620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5S86_RS09670	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5S86_RS09675	COG2259	Doxx family
I5S86_RS09685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5S86_RS09705	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I5S86_RS09710	COG4181	ATPase activity
I5S86_RS09725	COG1388	LysM domain
I5S86_RS09725	COG1376	ErfK ybiS ycfS ynhG family protein
I5S86_RS09745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5S86_RS09750	COG0589	response to stress
I5S86_RS09780	COG4067	protein conserved in archaea
I5S86_RS09780	COG0189	ligase activity
I5S86_RS09785	COG1802	Transcriptional regulator
I5S86_RS09795	COG0372	Belongs to the citrate synthase family
I5S86_RS09810	COG2079	MmgE PrpD family protein
I5S86_RS09830	COG0720	synthase
I5S86_RS09860	COG0517	IMP dehydrogenase activity
I5S86_RS09875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5S86_RS09895	COG0745	RESPONSE REGULATOR receiver
I5S86_RS09900	COG4251	negative regulation of phosphorylation
I5S86_RS09940	COG2866	Carboxypeptidase
I5S86_RS09975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5S86_RS09980	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS09985	COG0318	PFAM AMP-dependent synthetase and ligase
I5S86_RS10000	COG0366	Alpha amylase catalytic
I5S86_RS10005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I5S86_RS10030	COG1640	4-alpha-glucanotransferase
I5S86_RS10035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I5S86_RS10040	COG0297	glycogen (starch) synthase activity
I5S86_RS10050	COG4774	siderophore transport
I5S86_RS10055	COG3712	iron ion homeostasis
I5S86_RS10060	COG1595	DNA-templated transcription, initiation
I5S86_RS10070	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I5S86_RS10075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5S86_RS10080	COG3387	PFAM Glycoside hydrolase 15-related
I5S86_RS10085	COG1309	transcriptional regulator
I5S86_RS10105	COG1953	Uracil, thiamine, allantoin
I5S86_RS10115	COG1234	tRNA 3'-trailer cleavage
I5S86_RS10120	COG3040	lipid binding
I5S86_RS10125	COG1024	Enoyl-CoA hydratase
I5S86_RS10130	COG2816	NAD+ diphosphatase activity
I5S86_RS10145	COG0174	glutamine synthetase
I5S86_RS10150	COG1396	sequence-specific DNA binding
I5S86_RS10155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS10160	COG0596	Alpha beta hydrolase
I5S86_RS10165	COG1238	metal cluster binding
I5S86_RS10175	COG0826	peptidase U32
I5S86_RS10210	COG1007	ATP synthesis coupled electron transport
I5S86_RS10225	COG0713	ATP synthesis coupled electron transport
I5S86_RS10235	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5S86_RS10240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I5S86_RS10245	COG1034	ATP synthesis coupled electron transport
I5S86_RS10260	COG0649	NAD binding
I5S86_RS10260	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5S86_RS10265	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5S86_RS10270	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5S86_RS10285	COG2814	Major facilitator Superfamily
I5S86_RS10310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5S86_RS10315	COG1879	ABC-type sugar transport system periplasmic component
I5S86_RS10335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I5S86_RS10340	COG0316	Belongs to the HesB IscA family
I5S86_RS10340	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I5S86_RS10345	COG1999	signal sequence binding
I5S86_RS10400	COG0583	DNA-binding transcription factor activity
I5S86_RS10405	COG0417	DNA replication proofreading
I5S86_RS10415	COG2259	Doxx family
I5S86_RS10445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5S86_RS10450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I5S86_RS10465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5S86_RS10470	COG0765	amino acid transport
I5S86_RS10475	COG0765	amino acid transport
I5S86_RS10480	COG1126	abc transporter atp-binding protein
I5S86_RS10485	COG1192	Involved in chromosome partitioning
I5S86_RS10515	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I5S86_RS10520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5S86_RS10535	COG3842	ATPase activity
I5S86_RS10540	COG1177	transmembrane transport
I5S86_RS10545	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5S86_RS10555	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5S86_RS10565	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS10570	COG4191	Histidine kinase
I5S86_RS10570	COG0784	Response regulator, receiver
I5S86_RS10575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_RS10585	COG1285	pathogenesis
I5S86_RS10595	COG0789	Transcriptional regulator
I5S86_RS10600	COG2207	Transcriptional regulator
I5S86_RS10620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS10640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5S86_RS10650	COG0252	asparaginase activity
I5S86_RS10660	COG1129	ABC transporter
I5S86_RS10665	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5S86_RS10670	COG1609	Transcriptional regulator
I5S86_RS10675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5S86_RS10680	COG1869	D-ribose catabolic process
I5S86_RS10700	COG1278	Cold shock
I5S86_RS10710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5S86_RS10715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I5S86_RS10720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I5S86_RS10725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I5S86_RS10730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I5S86_RS10735	COG0072	phenylalanine-tRNA ligase activity
I5S86_RS10740	COG0776	regulation of translation
I5S86_RS10925	COG3646	Phage regulatory protein
I5S86_RS10970	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I5S86_RS10985	COG1598	PFAM Uncharacterised protein family UPF0150
I5S86_RS10990	COG1724	mRNA binding
I5S86_RS11240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5S86_RS11240	COG2890	protein-(glutamine-N5) methyltransferase activity
I5S86_RS11255	COG0583	DNA-binding transcription factor activity
I5S86_RS11270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5S86_RS11270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5S86_RS11275	COG0019	diaminopimelate decarboxylase activity
I5S86_RS11295	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I5S86_RS11305	COG2186	Transcriptional regulator
I5S86_RS11325	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS11350	COG0028	Belongs to the TPP enzyme family
I5S86_RS11360	COG3618	amidohydrolase
I5S86_RS11365	COG2159	amidohydrolase
I5S86_RS11415	COG0583	DNA-binding transcription factor activity
I5S86_RS11445	COG0604	alcohol dehydrogenase
I5S86_RS11445	COG3321	synthase
I5S86_RS11455	COG0302	gtp cyclohydrolase
I5S86_RS11485	COG2828	Protein conserved in bacteria
I5S86_RS11490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5S86_RS11495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5S86_RS11500	COG0583	DNA-binding transcription factor activity
I5S86_RS11510	COG3384	dioxygenase
I5S86_RS11535	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS11540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5S86_RS11545	COG2271	Major facilitator Superfamily
I5S86_RS11555	COG2113	Glycine betaine
I5S86_RS11560	COG4175	Glycine betaine
I5S86_RS11560	COG3448	diguanylate cyclase activity
I5S86_RS11565	COG4176	ABC-type proline glycine betaine transport system permease component
I5S86_RS11570	COG4176	ABC-type proline glycine betaine transport system permease component
I5S86_RS11580	COG0667	Aldo Keto reductase
I5S86_RS11590	COG1070	Carbohydrate kinase
I5S86_RS11595	COG0246	Mannitol dehydrogenase
I5S86_RS11610	COG1175	transmembrane transport
I5S86_RS11645	COG1024	Enoyl-CoA hydratase
I5S86_RS11650	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS11660	COG0183	Belongs to the thiolase family
I5S86_RS11665	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS11670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I5S86_RS11685	COG2814	Major facilitator Superfamily
I5S86_RS11695	COG2233	PERMEase
I5S86_RS11700	COG0583	DNA-binding transcription factor activity
I5S86_RS11745	COG1064	alcohol dehydrogenase
I5S86_RS11775	COG0840	transmembrane signaling receptor activity
I5S86_RS11780	COG2056	Na+-H+ antiporter family
I5S86_RS11795	COG1566	PFAM secretion protein HlyD family protein
I5S86_RS11800	COG2814	Major facilitator Superfamily
I5S86_RS11835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5S86_RS11840	COG1121	(ABC) transporter
I5S86_RS11880	COG1686	Belongs to the peptidase S11 family
I5S86_RS11890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5S86_RS11930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5S86_RS11940	COG2205	protein histidine kinase activity
I5S86_RS11945	COG2198	Histidine kinase
I5S86_RS11945	COG2205	protein histidine kinase activity
I5S86_RS11945	COG0784	Response regulator, receiver
I5S86_RS11945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_RS11950	COG0113	porphobilinogen synthase activity
I5S86_RS11960	COG0307	riboflavin synthase, alpha
I5S86_RS11975	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I5S86_RS11985	COG1984	allophanate hydrolase subunit 2
I5S86_RS12005	COG4106	trans-aconitate 2-methyltransferase activity
I5S86_RS12015	COG0019	diaminopimelate decarboxylase activity
I5S86_RS12035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5S86_RS12040	COG0583	DNA-binding transcription factor activity
I5S86_RS12065	COG1309	transcriptional regulator
I5S86_RS12070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I5S86_RS12070	COG2010	Cytochrome c
I5S86_RS12075	COG2080	2 iron, 2 sulfur cluster binding
I5S86_RS12080	COG1846	Transcriptional regulator
I5S86_RS12085	COG2309	aminopeptidase activity
I5S86_RS12090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5S86_RS12095	COG0596	Alpha beta hydrolase
I5S86_RS12100	COG3473	Maleate cis-trans isomerase
I5S86_RS12105	COG1335	isochorismatase
I5S86_RS12110	COG2271	Major facilitator Superfamily
I5S86_RS12120	COG1053	succinate dehydrogenase
I5S86_RS12130	COG0673	inositol 2-dehydrogenase activity
I5S86_RS12140	COG1053	succinate dehydrogenase
I5S86_RS12150	COG1053	succinate dehydrogenase
I5S86_RS12155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5S86_RS12160	COG1414	Transcriptional regulator
I5S86_RS12170	COG3237	CsbD-like
I5S86_RS12185	COG1228	amidohydrolase
I5S86_RS12220	COG1228	amidohydrolase
I5S86_RS12250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5S86_RS12290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5S86_RS12295	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I5S86_RS12310	COG1132	(ABC) transporter
I5S86_RS12325	COG0668	transmembrane transport
I5S86_RS12335	COG1450	Type ii and iii secretion system protein
I5S86_RS12350	COG3166	PFAM Fimbrial assembly family protein
I5S86_RS12355	COG3156	type II secretion system protein K
I5S86_RS12365	COG2165	general secretion pathway protein
I5S86_RS12370	COG4970	Tfp pilus assembly protein FimT
I5S86_RS12375	COG2165	general secretion pathway protein
I5S86_RS12380	COG1459	type II secretion system
I5S86_RS12385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5S86_RS12395	COG1472	Belongs to the glycosyl hydrolase 3 family
I5S86_RS12420	COG3220	belongs to the UPF0276 family
I5S86_RS12430	COG1595	DNA-templated transcription, initiation
I5S86_RS12435	COG4944	Protein of unknown function (DUF1109)
I5S86_RS12445	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5S86_RS12450	COG0183	Belongs to the thiolase family
I5S86_RS12465	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I5S86_RS12470	COG0247	lactate metabolic process
I5S86_RS12475	COG0277	FAD linked oxidase domain protein
I5S86_RS12480	COG0277	FAD linked oxidase domain protein
I5S86_RS12485	COG2186	Transcriptional regulator
I5S86_RS12510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5S86_RS12520	COG0402	S-adenosylhomocysteine deaminase activity
I5S86_RS12545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_RS12555	COG4106	trans-aconitate 2-methyltransferase activity
I5S86_RS12565	COG0583	DNA-binding transcription factor activity
I5S86_RS12575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS12580	COG0217	transcriptional regulatory protein
I5S86_RS12590	COG0076	glutamate decarboxylase activity
I5S86_RS12595	COG0477	Major facilitator Superfamily
I5S86_RS12600	COG1082	Xylose isomerase domain protein TIM barrel
I5S86_RS12600	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I5S86_RS12605	COG1309	transcriptional regulator
I5S86_RS12630	COG5001	Diguanylate cyclase
I5S86_RS12635	COG0656	L-ascorbic acid biosynthetic process
I5S86_RS12645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I5S86_RS12655	COG0477	Major facilitator Superfamily
I5S86_RS12665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5S86_RS12670	COG3300	MHYT domain
I5S86_RS12670	COG5001	Diguanylate cyclase
I5S86_RS12675	COG1611	Belongs to the LOG family
I5S86_RS12680	COG2855	membrane
I5S86_RS12725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5S86_RS12745	COG4191	Histidine kinase
I5S86_RS12745	COG0784	Response regulator, receiver
I5S86_RS12750	COG2816	NAD+ diphosphatase activity
I5S86_RS12755	COG2186	Transcriptional regulator
I5S86_RS12760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5S86_RS12770	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS12775	COG2267	carboxylic ester hydrolase activity
I5S86_RS12785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5S86_RS12795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5S86_RS12810	COG1959	2 iron, 2 sulfur cluster binding
I5S86_RS12820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5S86_RS12830	COG4991	sh3 domain protein
I5S86_RS12845	COG3180	Ammonia monooxygenase
I5S86_RS12850	COG0583	DNA-binding transcription factor activity
I5S86_RS12855	COG1252	NADH dehydrogenase
I5S86_RS12870	COG0393	Putative heavy-metal-binding
I5S86_RS12910	COG4221	oxidoreductase activity
I5S86_RS12920	COG1917	Cupin 2, conserved barrel domain protein
I5S86_RS12920	COG1396	sequence-specific DNA binding
I5S86_RS12925	COG0477	Major facilitator Superfamily
I5S86_RS12930	COG3038	cytochrome b561
I5S86_RS12935	COG0753	catalase activity
I5S86_RS12940	COG1595	DNA-templated transcription, initiation
I5S86_RS12950	COG0708	Exodeoxyribonuclease III
I5S86_RS12960	COG0729	surface antigen
I5S86_RS12965	COG2911	Protein conserved in bacteria
I5S86_RS13000	COG2366	antibiotic biosynthetic process
I5S86_RS13005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5S86_RS13015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5S86_RS13020	COG0215	cysteine-tRNA ligase activity
I5S86_RS13030	COG0745	RESPONSE REGULATOR receiver
I5S86_RS13035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5S86_RS13050	COG0829	nickel cation binding
I5S86_RS13055	COG0831	urea catabolic process
I5S86_RS13060	COG0832	Belongs to the urease beta subunit family
I5S86_RS13065	COG0804	urea catabolic process
I5S86_RS13070	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I5S86_RS13080	COG0830	nickel cation binding
I5S86_RS13085	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I5S86_RS13100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5S86_RS13105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5S86_RS13120	COG0587	DNA-directed DNA polymerase activity
I5S86_RS13125	COG0656	L-ascorbic acid biosynthetic process
I5S86_RS13135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5S86_RS13145	COG2031	fatty acid transporter
I5S86_RS13160	COG1253	flavin adenine dinucleotide binding
I5S86_RS13170	COG2200	EAL domain
I5S86_RS13215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_RS13280	COG2204	response regulator
I5S86_RS13285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5S86_RS13310	COG1450	Type ii and iii secretion system protein
I5S86_RS13350	COG3145	DNA-N1-methyladenine dioxygenase activity
I5S86_RS13360	COG1280	lysine exporter protein (LysE YggA)
I5S86_RS13375	COG3773	Cell wall hydrolase
I5S86_RS13395	COG3257	ureidoglycine aminohydrolase activity
I5S86_RS13400	COG2226	methyltransferase
I5S86_RS13555	COG3209	COG3209 Rhs family protein
I5S86_RS13575	COG3209	COG3209 Rhs family protein
I5S86_RS13605	COG3209	COG3209 Rhs family protein
I5S86_RS13615	COG3209	COG3209 Rhs family protein
I5S86_RS13635	COG3209	COG3209 Rhs family protein
I5S86_RS13645	COG3436	PFAM IS66 Orf2 family protein
I5S86_RS13715	COG1473	amidohydrolase
I5S86_RS13725	COG0154	amidase activity
I5S86_RS13730	COG1414	Transcriptional regulator
I5S86_RS13735	COG4181	ATPase activity
I5S86_RS13740	COG0577	efflux transmembrane transporter activity
I5S86_RS13750	COG0667	Aldo Keto reductase
I5S86_RS13765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5S86_RS13770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5S86_RS13780	COG2271	Major facilitator Superfamily
I5S86_RS13805	COG1609	Transcriptional regulator
I5S86_RS13815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5S86_RS13820	COG2271	Major facilitator Superfamily
I5S86_RS13830	COG0644	oxidoreductase
I5S86_RS13845	COG2814	Major facilitator Superfamily
I5S86_RS13850	COG0531	amino acid
I5S86_RS13870	COG3781	membrane
I5S86_RS13875	COG4191	Histidine kinase
I5S86_RS13875	COG0784	Response regulator, receiver
I5S86_RS13885	COG0714	Associated with various cellular activities
I5S86_RS13920	COG3119	arylsulfatase activity
I5S86_RS13935	COG3008	intermembrane lipid transfer
I5S86_RS13940	COG2995	paraquat-inducible protein a
I5S86_RS13955	COG2985	domain, Protein
I5S86_RS13960	COG0668	transmembrane transport
I5S86_RS13980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5S86_RS14025	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5S86_RS14035	COG2207	Transcriptional regulator
I5S86_RS14050	COG0693	protein deglycase activity
I5S86_RS14055	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS14060	COG2323	membrane
I5S86_RS14065	COG0494	nUDIX hydrolase
I5S86_RS14090	COG3546	catalase activity
I5S86_RS14220	COG2217	Heavy metal translocating P-type atpase
I5S86_RS14225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5S86_RS14230	COG1074	ATP-dependent DNA helicase activity
I5S86_RS14265	COG2132	Multicopper oxidase
I5S86_RS14300	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_RS14305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_RS14335	COG0789	Transcriptional regulator
I5S86_RS14360	COG1741	Belongs to the pirin family
I5S86_RS14365	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5S86_RS14370	COG2814	Major facilitator Superfamily
I5S86_RS14380	COG3038	cytochrome b561
I5S86_RS14395	COG0583	DNA-binding transcription factor activity
I5S86_RS14400	COG3038	cytochrome b561
I5S86_RS14405	COG2353	YceI-like domain
I5S86_RS14410	COG2353	YceI-like domain
I5S86_RS14450	COG0523	cobalamin synthesis protein
I5S86_RS14455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5S86_RS14465	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS14485	COG1024	Enoyl-CoA hydratase
I5S86_RS14530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I5S86_RS14530	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5S86_RS14545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5S86_RS14565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5S86_RS14570	COG2218	PFAM glutamate synthase alpha subunit domain protein
I5S86_RS14575	COG0069	glutamate synthase activity
I5S86_RS14580	COG0004	ammonium transporteR
I5S86_RS14655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5S86_RS14710	COG1063	alcohol dehydrogenase
I5S86_RS14730	COG3568	Endonuclease Exonuclease Phosphatase
I5S86_RS14735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5S86_RS14740	COG0392	lysyltransferase activity
I5S86_RS14795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5S86_RS14800	COG2890	protein-(glutamine-N5) methyltransferase activity
I5S86_RS14830	COG2837	iron assimilation
I5S86_RS14845	COG1285	pathogenesis
I5S86_RS14850	COG5001	Diguanylate cyclase
I5S86_RS14850	COG4251	negative regulation of phosphorylation
I5S86_RS14850	COG3706	GGDEF domain
I5S86_RS14850	COG2203	Gaf domain
I5S86_RS14890	COG2423	ornithine cyclodeaminase activity
I5S86_RS14895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5S86_RS14900	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5S86_RS14925	COG3386	PFAM SMP-30 Gluconolaconase
I5S86_RS14930	COG0583	DNA-binding transcription factor activity
I5S86_RS14935	COG0367	asparagine synthase
I5S86_RS14940	COG0154	amidase activity
I5S86_RS14970	COG1929	Belongs to the glycerate kinase type-1 family
I5S86_RS14975	COG3835	regulator
I5S86_RS14980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5S86_RS14985	COG3284	Transcriptional regulator
I5S86_RS14990	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS15000	COG1902	pentaerythritol trinitrate reductase activity
I5S86_RS15005	COG0583	DNA-binding transcription factor activity
I5S86_RS15025	COG3135	benzoate transporter
I5S86_RS15030	COG3485	protocatechuate 3,4-dioxygenase
I5S86_RS15035	COG4829	muconolactone delta-isomerase
I5S86_RS15040	COG4948	Mandelate Racemase Muconate Lactonizing
I5S86_RS15045	COG2814	Major facilitator Superfamily
I5S86_RS15070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5S86_RS15075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5S86_RS15080	COG4166	transmembrane transport
I5S86_RS15085	COG4174	ABC transporter (Permease)
I5S86_RS15090	COG4239	(ABC) transporter, permease
I5S86_RS15095	COG3290	protein histidine kinase activity
I5S86_RS15095	COG3829	transcription factor binding
I5S86_RS15100	COG2610	gluconate transmembrane transporter activity
I5S86_RS15105	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS15110	COG4574	serine-type endopeptidase inhibitor activity
I5S86_RS15115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5S86_RS15120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5S86_RS15140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5S86_RS15155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5S86_RS15185	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5S86_RS15195	COG1301	dicarboxylic acid transport
I5S86_RS15205	COG0583	DNA-binding transcription factor activity
I5S86_RS15245	COG0488	(ABC) transporter
I5S86_RS15255	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I5S86_RS15260	COG0583	DNA-binding transcription factor activity
I5S86_RS15275	COG1968	undecaprenyl-diphosphatase activity
I5S86_RS15280	COG0840	transmembrane signaling receptor activity
I5S86_RS15330	COG2204	response regulator
I5S86_RS15360	COG0456	acetyltransferase
I5S86_RS15365	COG2433	Pfam Transposase IS66
I5S86_RS15375	COG2963	transposase activity
I5S86_RS15400	COG3813	Protein conserved in bacteria
I5S86_RS15405	COG2197	response regulator
I5S86_RS15410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_RS15410	COG2205	protein histidine kinase activity
I5S86_RS15420	COG1609	Transcriptional regulator
I5S86_RS15425	COG3265	gluconokinase activity
I5S86_RS15440	COG2204	response regulator
I5S86_RS15445	COG4191	Histidine kinase
I5S86_RS15450	COG5002	protein histidine kinase activity
I5S86_RS15455	COG0741	lytic transglycosylase activity
I5S86_RS15465	COG1459	type II secretion system
I5S86_RS15470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5S86_RS15515	COG0814	amino acid
I5S86_RS15520	COG1448	Aminotransferase
I5S86_RS15540	COG4215	(ABC) transporter
I5S86_RS15550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS15555	COG1126	abc transporter atp-binding protein
I5S86_RS15560	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5S86_RS15565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5S86_RS15570	COG2271	Major facilitator Superfamily
I5S86_RS15575	COG2721	sulfolactate sulfo-lyase activity
I5S86_RS15580	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS15585	COG2186	Transcriptional regulator
I5S86_RS15600	COG0583	DNA-binding transcription factor activity
I5S86_RS15610	COG2391	methyltransferase activity
I5S86_RS15650	COG1944	ATP diphosphatase activity
I5S86_RS15670	COG3608	succinylglutamate desuccinylase aspartoacylase
I5S86_RS15670	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I5S86_RS15695	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS15700	COG2271	Major facilitator Superfamily
I5S86_RS15720	COG2205	protein histidine kinase activity
I5S86_RS15725	COG0745	RESPONSE REGULATOR receiver
I5S86_RS15730	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5S86_RS15755	COG3220	belongs to the UPF0276 family
I5S86_RS15765	COG2116	formate transmembrane transporter activity
I5S86_RS15770	COG2080	2 iron, 2 sulfur cluster binding
I5S86_RS15775	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I5S86_RS15780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I5S86_RS15795	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS15810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I5S86_RS15825	COG0840	transmembrane signaling receptor activity
I5S86_RS15830	COG0745	RESPONSE REGULATOR receiver
I5S86_RS15835	COG2205	protein histidine kinase activity
I5S86_RS15840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_RS15845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_RS15865	COG2384	SAM-dependent methyltransferase
I5S86_RS15885	COG2184	nucleotidyltransferase activity
I5S86_RS15915	COG0826	peptidase U32
I5S86_RS15925	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS15950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5S86_RS15970	COG3052	prosthetic group binding
I5S86_RS15990	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS16035	COG0583	DNA-binding transcription factor activity
I5S86_RS16040	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS16045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5S86_RS16055	COG0174	glutamine synthetase
I5S86_RS16065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS16070	COG1760	l-serine dehydratase
I5S86_RS16075	COG0583	DNA-binding transcription factor activity
I5S86_RS16080	COG2194	sulfuric ester hydrolase activity
I5S86_RS16095	COG1215	transferase activity, transferring glycosyl groups
I5S86_RS16105	COG2990	Protein conserved in bacteria
I5S86_RS16115	COG1045	serine acetyltransferase
I5S86_RS16125	COG0110	maltose O-acetyltransferase activity
I5S86_RS16155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5S86_RS16220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5S86_RS16230	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5S86_RS16235	COG1215	transferase activity, transferring glycosyl groups
I5S86_RS16250	COG2205	protein histidine kinase activity
I5S86_RS16260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_RS16345	COG0346	lactoylglutathione lyase activity
I5S86_RS16360	COG0596	Alpha beta hydrolase
I5S86_RS16370	COG0210	DNA helicase
I5S86_RS16385	COG1199	ATP-dependent helicase activity
I5S86_RS16385	COG1199	ATP-dependent helicase activity
I5S86_RS16410	COG0604	alcohol dehydrogenase
I5S86_RS16410	COG3321	synthase
I5S86_RS16410	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS16420	COG0156	8-amino-7-oxononanoate synthase activity
I5S86_RS16425	COG2301	Belongs to the HpcH HpaI aldolase family
I5S86_RS16445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5S86_RS16480	COG0495	leucyl-tRNA aminoacylation
I5S86_RS16485	COG0028	Belongs to the TPP enzyme family
I5S86_RS16495	COG0406	alpha-ribazole phosphatase activity
I5S86_RS16515	COG2194	sulfuric ester hydrolase activity
I5S86_RS16535	COG0531	amino acid
I5S86_RS16540	COG3845	ABC transporter
I5S86_RS16545	COG4603	Belongs to the binding-protein-dependent transport system permease family
I5S86_RS16550	COG1079	Belongs to the binding-protein-dependent transport system permease family
I5S86_RS16565	COG3046	protein related to deoxyribodipyrimidine photolyase
I5S86_RS16590	COG0864	Transcriptional regulator
I5S86_RS16595	COG0747	negative chemotaxis
I5S86_RS16600	COG0601	transmembrane transport
I5S86_RS16605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5S86_RS16610	COG0444	Belongs to the ABC transporter superfamily
I5S86_RS16615	COG1124	(ABC) transporter
I5S86_RS16625	COG2308	Evidence 4 Homologs of previously reported genes of
I5S86_RS16635	COG1305	Transglutaminase-like
I5S86_RS16675	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS16685	COG0318	PFAM AMP-dependent synthetase and ligase
I5S86_RS16710	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5S86_RS16735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5S86_RS16755	COG0583	DNA-binding transcription factor activity
I5S86_RS16775	COG2080	2 iron, 2 sulfur cluster binding
I5S86_RS16785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I5S86_RS16800	COG0702	epimerase
I5S86_RS16810	COG0667	Aldo Keto reductase
I5S86_RS16820	COG0667	Aldo Keto reductase
I5S86_RS16840	COG1073	alpha beta
I5S86_RS16860	COG3064	Membrane
I5S86_RS16875	COG0583	DNA-binding transcription factor activity
I5S86_RS16880	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I5S86_RS16885	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS16890	COG2079	MmgE PrpD family protein
I5S86_RS16920	COG0583	DNA-binding transcription factor activity
I5S86_RS16925	COG0405	Gamma-glutamyltransferase
I5S86_RS16950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5S86_RS16955	COG0768	penicillin binding
I5S86_RS16965	COG0861	Integral membrane protein TerC family
I5S86_RS16990	COG1104	cysteine desulfurase activity
I5S86_RS17000	COG0583	DNA-binding transcription factor activity
I5S86_RS17015	COG2814	Major facilitator Superfamily
I5S86_RS17020	COG1064	alcohol dehydrogenase
I5S86_RS17025	COG2207	Transcriptional regulator
I5S86_RS17045	COG0625	glutathione transferase activity
I5S86_RS17090	COG0477	Major facilitator Superfamily
I5S86_RS17095	COG0506	proline dehydrogenase activity
I5S86_RS17095	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I5S86_RS17095	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I5S86_RS17105	COG0583	DNA-binding transcription factor activity
I5S86_RS17110	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I5S86_RS17130	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
I5S86_RS17145	COG3706	GGDEF domain
I5S86_RS17165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5S86_RS17170	COG0581	inorganic phosphate transmembrane transporter activity
I5S86_RS17180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5S86_RS17195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_RS17200	COG0697	spore germination
I5S86_RS17220	COG2067	long-chain fatty acid transport protein
I5S86_RS17225	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I5S86_RS17310	COG4974	Belongs to the 'phage' integrase family
I5S86_RS17350	COG0726	polysaccharide deacetylase
I5S86_RS17365	COG0174	glutamine synthetase
I5S86_RS17370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS17380	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS17425	COG1454	alcohol dehydrogenase
I5S86_RS17430	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS17435	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5S86_RS17435	COG1024	Enoyl-CoA hydratase
I5S86_RS17440	COG0583	DNA-binding transcription factor activity
I5S86_RS17445	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I5S86_RS17465	COG0583	DNA-binding transcription factor activity
I5S86_RS17475	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS17480	COG0318	PFAM AMP-dependent synthetase and ligase
I5S86_RS17490	COG2851	Citrate transporter
I5S86_RS17495	COG1301	dicarboxylic acid transport
I5S86_RS17500	COG2828	Protein conserved in bacteria
I5S86_RS17505	COG0583	DNA-binding transcription factor activity
I5S86_RS17520	COG1090	epimerase
I5S86_RS17530	COG2814	Major facilitator Superfamily
I5S86_RS17535	COG0583	DNA-binding transcription factor activity
I5S86_RS17540	COG0789	Transcriptional regulator
I5S86_RS17545	COG2202	Pas domain
I5S86_RS17545	COG1366	Belongs to the anti-sigma-factor antagonist family
I5S86_RS17555	COG4221	oxidoreductase activity
I5S86_RS17570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5S86_RS17590	COG2271	Major facilitator Superfamily
I5S86_RS17595	COG1253	flavin adenine dinucleotide binding
I5S86_RS17605	COG0583	DNA-binding transcription factor activity
I5S86_RS17610	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I5S86_RS17615	COG3132	Protein of unknown function, DUF480
I5S86_RS17625	COG3634	alkyl hydroperoxide reductase activity
I5S86_RS17650	COG3258	Cytochrome c
I5S86_RS17655	COG2863	cytochrome
I5S86_RS17690	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I5S86_RS17700	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5S86_RS17705	COG0745	RESPONSE REGULATOR receiver
I5S86_RS17710	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I5S86_RS17715	COG0784	Response regulator, receiver
I5S86_RS17715	COG4191	Histidine kinase
I5S86_RS17725	COG2259	Doxx family
I5S86_RS17750	COG0583	DNA-binding transcription factor activity
I5S86_RS17755	COG3321	synthase
I5S86_RS17755	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS17755	COG0604	alcohol dehydrogenase
I5S86_RS17765	COG0616	signal peptide processing
I5S86_RS17785	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS17790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5S86_RS17820	COG0471	metal ion transport
I5S86_RS17820	COG0490	domain, Protein
I5S86_RS17825	COG2199	diguanylate cyclase activity
I5S86_RS17885	COG2885	chlorophyll binding
I5S86_RS17935	COG3179	chitinase
I5S86_RS17955	COG2885	chlorophyll binding
I5S86_RS18030	COG0629	single-stranded DNA binding
I5S86_RS18035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5S86_RS18205	COG1569	PIN domain
I5S86_RS18210	COG3311	Transcriptional regulator
I5S86_RS18265	COG2003	Belongs to the UPF0758 family
I5S86_RS18320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5S86_RS18320	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5S86_RS18325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5S86_RS18330	COG1252	NADH dehydrogenase
I5S86_RS18335	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I5S86_RS18390	COG0583	DNA-binding transcription factor activity
I5S86_RS18400	COG0583	DNA-binding transcription factor activity
I5S86_RS18415	COG2837	iron assimilation
I5S86_RS18420	COG0582	viral genome integration into host DNA
I5S86_RS18435	COG0322	excinuclease ABC activity
I5S86_RS18455	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I5S86_RS18455	COG2050	protein possibly involved in aromatic compounds catabolism
I5S86_RS18460	COG1113	amino acid transport
I5S86_RS18465	COG0583	DNA-binding transcription factor activity
I5S86_RS18470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5S86_RS18485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5S86_RS18490	COG0659	secondary active sulfate transmembrane transporter activity
I5S86_RS18545	COG0840	transmembrane signaling receptor activity
I5S86_RS18550	COG1113	amino acid transport
I5S86_RS18580	COG2807	transmembrane transport
I5S86_RS18595	COG3842	ATPase activity
I5S86_RS18600	COG1177	transmembrane transport
I5S86_RS18605	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5S86_RS18610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5S86_RS18630	COG2508	Transcriptional regulator
I5S86_RS18635	COG0583	DNA-binding transcription factor activity
I5S86_RS18665	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5S86_RS18680	COG2271	Major facilitator Superfamily
I5S86_RS18705	COG1192	Involved in chromosome partitioning
I5S86_RS18750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5S86_RS18865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I5S86_RS18870	COG0386	Belongs to the glutathione peroxidase family
I5S86_RS18890	COG1024	Enoyl-CoA hydratase
I5S86_RS18895	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS18900	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS18910	COG2124	cytochrome p450
I5S86_RS18920	COG0183	Belongs to the thiolase family
I5S86_RS18925	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5S86_RS18930	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5S86_RS18960	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I5S86_RS18970	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5S86_RS18975	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS19020	COG2223	nitrite transmembrane transporter activity
I5S86_RS19025	COG0633	Ferredoxin
I5S86_RS19035	COG4221	oxidoreductase activity
I5S86_RS19050	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS19060	COG2124	cytochrome p450
I5S86_RS19065	COG1309	transcriptional regulator
I5S86_RS19075	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS19080	COG1024	Enoyl-CoA hydratase
I5S86_RS19095	COG4447	cellulose binding
I5S86_RS19110	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS19130	COG0583	DNA-binding transcription factor activity
I5S86_RS19135	COG1063	alcohol dehydrogenase
I5S86_RS19150	COG0840	transmembrane signaling receptor activity
I5S86_RS19170	COG1546	Belongs to the CinA family
I5S86_RS19170	COG1058	Belongs to the CinA family
I5S86_RS19180	COG2323	membrane
I5S86_RS19350	COG1238	metal cluster binding
I5S86_RS19375	COG1230	cation diffusion facilitator family transporter
I5S86_RS19385	COG2814	Major facilitator Superfamily
I5S86_RS19435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5S86_RS19495	COG2323	membrane
I5S86_RS19535	COG3920	Histidine kinase
I5S86_RS19610	COG1063	alcohol dehydrogenase
I5S86_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS19625	COG3328	transposase activity
I5S86_RS19690	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS19700	COG1058	Belongs to the CinA family
I5S86_RS19700	COG1546	Belongs to the CinA family
I5S86_RS19710	COG2323	membrane
I5S86_RS19725	COG3387	PFAM Glycoside hydrolase 15-related
I5S86_RS19745	COG2205	protein histidine kinase activity
I5S86_RS19810	COG4974	Belongs to the 'phage' integrase family
I5S86_RS19830	COG2233	PERMEase
I5S86_RS19855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5S86_RS19860	COG0435	Glutathione S-transferase
I5S86_RS19865	COG1648	precorrin-2 dehydrogenase activity
I5S86_RS19865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I5S86_RS19870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I5S86_RS19875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I5S86_RS19880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5S86_RS19885	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I5S86_RS19890	COG1674	ftsk spoiiie
I5S86_RS19895	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I5S86_RS19900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I5S86_RS19905	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I5S86_RS19910	COG0542	response to heat
I5S86_RS19915	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I5S86_RS19920	COG1278	Cold shock
I5S86_RS19940	COG0482	sulfurtransferase activity
I5S86_RS19945	COG2915	High frequency lysogenization protein hflD homolog
I5S86_RS19955	COG2850	peptidyl-arginine hydroxylation
I5S86_RS19960	COG2153	protein acetylation
I5S86_RS19975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5S86_RS19980	COG2133	pyrroloquinoline quinone binding
I5S86_RS20010	COG0589	response to stress
I5S86_RS20075	COG1335	isochorismatase
I5S86_RS20090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5S86_RS20090	COG2111	Na H antiporter
I5S86_RS20095	COG1006	Multisubunit Na H antiporter MnhC subunit
I5S86_RS20100	COG0651	ATP synthesis coupled electron transport
I5S86_RS20110	COG2212	antiporter activity
I5S86_RS20115	COG1320	monovalent cation:proton antiporter activity
I5S86_RS20150	COG1024	Enoyl-CoA hydratase
I5S86_RS20155	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS20160	COG0183	Belongs to the thiolase family
I5S86_RS20170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5S86_RS20175	COG2207	Transcriptional regulator
I5S86_RS20180	COG0583	DNA-binding transcription factor activity
I5S86_RS20185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5S86_RS20190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5S86_RS20195	COG0431	NADPH-dependent FMN reductase
I5S86_RS20210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5S86_RS20215	COG0328	RNA-DNA hybrid ribonuclease activity
I5S86_RS20225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5S86_RS20230	COG1388	LysM domain
I5S86_RS20230	COG0741	lytic transglycosylase activity
I5S86_RS20240	COG4166	transmembrane transport
I5S86_RS20245	COG4174	ABC transporter (Permease)
I5S86_RS20250	COG4239	(ABC) transporter, permease
I5S86_RS20255	COG4172	Belongs to the ABC transporter superfamily
I5S86_RS20260	COG1595	DNA-templated transcription, initiation
I5S86_RS20265	COG3712	iron ion homeostasis
I5S86_RS20275	COG2271	Major facilitator Superfamily
I5S86_RS20285	COG4251	negative regulation of phosphorylation
I5S86_RS20285	COG2203	Gaf domain
I5S86_RS20285	COG3706	GGDEF domain
I5S86_RS20285	COG5001	Diguanylate cyclase
I5S86_RS20290	COG0745	RESPONSE REGULATOR receiver
I5S86_RS20295	COG2205	protein histidine kinase activity
I5S86_RS20300	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I5S86_RS20310	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I5S86_RS20320	COG0628	permease
I5S86_RS20330	COG0596	Alpha beta hydrolase
I5S86_RS20350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I5S86_RS20365	COG4999	Histidine kinase
I5S86_RS20365	COG3850	Histidine kinase
I5S86_RS20365	COG3437	response regulator, receiver
I5S86_RS20365	COG2205	protein histidine kinase activity
I5S86_RS20370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5S86_RS20385	COG1741	Belongs to the pirin family
I5S86_RS20395	COG0326	Molecular chaperone. Has ATPase activity
I5S86_RS20430	COG0045	succinate-CoA ligase (ADP-forming) activity
I5S86_RS20435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5S86_RS20455	COG1053	succinate dehydrogenase
I5S86_RS20460	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I5S86_RS20465	COG2009	succinate dehydrogenase
I5S86_RS20490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_RS20495	COG3047	cAMP biosynthetic process
I5S86_RS20495	COG2885	chlorophyll binding
I5S86_RS20525	COG2944	sequence-specific DNA binding
I5S86_RS20535	COG0477	Major facilitator Superfamily
I5S86_RS20540	COG2198	Histidine kinase
I5S86_RS20540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_RS20540	COG0784	Response regulator, receiver
I5S86_RS20540	COG2205	protein histidine kinase activity
I5S86_RS20550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_RS20555	COG1136	(ABC) transporter
I5S86_RS20555	COG0577	efflux transmembrane transporter activity
I5S86_RS20560	COG1538	Outer membrane efflux protein
I5S86_RS20580	COG0515	serine threonine protein kinase
I5S86_RS20580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I5S86_RS20590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5S86_RS20600	COG0657	acetylesterase activity
I5S86_RS20610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5S86_RS20630	COG0642	Histidine kinase
I5S86_RS20645	COG3608	succinylglutamate desuccinylase aspartoacylase
I5S86_RS20645	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I5S86_RS20670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5S86_RS20705	COG3123	guanosine phosphorylase activity
I5S86_RS20715	COG3278	Belongs to the heme-copper respiratory oxidase family
I5S86_RS20730	COG2010	Cytochrome c
I5S86_RS20735	COG3278	Belongs to the heme-copper respiratory oxidase family
I5S86_RS20750	COG2010	Cytochrome c
I5S86_RS20755	COG0348	domain, Protein
I5S86_RS20765	COG2217	Heavy metal translocating P-type atpase
I5S86_RS20785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5S86_RS20790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5S86_RS20795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I5S86_RS20800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I5S86_RS20805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I5S86_RS20815	COG0789	Transcriptional regulator
I5S86_RS20825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I5S86_RS20830	COG3115	cell septum assembly
I5S86_RS20840	COG2186	Transcriptional regulator
I5S86_RS20860	COG0402	S-adenosylhomocysteine deaminase activity
I5S86_RS20865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5S86_RS20875	COG2252	PERMEase
I5S86_RS20895	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I5S86_RS20905	COG2233	PERMEase
I5S86_RS20920	COG2354	Protein conserved in bacteria
I5S86_RS20935	COG3960	tartronate-semialdehyde synthase activity
I5S86_RS20940	COG3622	Belongs to the hyi family
I5S86_RS20945	COG2084	Dehydrogenase
I5S86_RS20955	COG0469	pyruvate kinase activity
I5S86_RS20965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5S86_RS20975	COG0116	Belongs to the methyltransferase superfamily
I5S86_RS20975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5S86_RS20985	COG1522	sequence-specific DNA binding
I5S86_RS20990	COG1953	Uracil, thiamine, allantoin
I5S86_RS21020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5S86_RS21045	COG1138	Cytochrome C-type biogenesis protein
I5S86_RS21050	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I5S86_RS21070	COG4133	protoheme IX ABC transporter activity
I5S86_RS21080	COG2257	FlhB HrpN YscU SpaS Family
I5S86_RS21095	COG0835	chemotaxis
I5S86_RS21105	COG1192	Involved in chromosome partitioning
I5S86_RS21110	COG1360	Flagellar Motor Protein
I5S86_RS21115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I5S86_RS21120	COG2201	protein-glutamate methylesterase activity
I5S86_RS21125	COG2198	Histidine kinase
I5S86_RS21125	COG0784	Response regulator, receiver
I5S86_RS21125	COG0643	Histidine kinase
I5S86_RS21130	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I5S86_RS21170	COG1987	bacterial-type flagellum assembly
I5S86_RS21210	COG0745	RESPONSE REGULATOR receiver
I5S86_RS21220	COG2882	bacterial-type flagellum organization
I5S86_RS21245	COG1677	Flagellar hook-basal body complex protein FliE
I5S86_RS21275	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I5S86_RS21285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5S86_RS21300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5S86_RS21305	COG2089	acid synthase
I5S86_RS21315	COG1083	cytidylyl-transferase
I5S86_RS21320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I5S86_RS21325	COG1086	Polysaccharide biosynthesis protein
I5S86_RS21365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I5S86_RS21370	COG0438	transferase activity, transferring glycosyl groups
I5S86_RS21370	COG1216	Glycosyl transferase, family 2
I5S86_RS21380	COG1256	bacterial-type flagellum assembly
I5S86_RS21390	COG1706	bacterial-type flagellum-dependent cell motility
I5S86_RS21395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I5S86_RS21405	COG4787	bacterial-type flagellum-dependent cell motility
I5S86_RS21415	COG1749	Flagellar hook protein flgE
I5S86_RS21430	COG1815	bacterial-type flagellum-dependent cell motility
I5S86_RS21435	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5S86_RS21440	COG0835	chemotaxis
I5S86_RS21440	COG0784	Response regulator, receiver
I5S86_RS21460	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I5S86_RS21465	COG0477	Major facilitator Superfamily
I5S86_RS21475	COG1522	sequence-specific DNA binding
I5S86_RS21480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5S86_RS21485	COG0022	dehydrogenase e1 component
I5S86_RS21495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5S86_RS21550	COG1215	transferase activity, transferring glycosyl groups
I5S86_RS21555	COG2356	endonuclease I
I5S86_RS21565	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I5S86_RS21575	COG2239	Acts as a magnesium transporter
I5S86_RS21600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5S86_RS21605	COG0527	aspartate kinase activity
I5S86_RS21610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I5S86_RS21615	COG2988	succinylglutamate desuccinylase activity
I5S86_RS21625	COG3724	N-succinylarginine dihydrolase activity
I5S86_RS21630	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS21645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5S86_RS21665	COG4215	(ABC) transporter
I5S86_RS21670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_RS21675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5S86_RS21695	COG2154	pterin-4-alpha-carbinolamine dehydratase
I5S86_RS21705	COG0277	FAD linked oxidase domain protein
I5S86_RS21705	COG0247	lactate metabolic process
I5S86_RS21710	COG0583	DNA-binding transcription factor activity
I5S86_RS21725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I5S86_RS21735	COG0009	L-threonylcarbamoyladenylate synthase
I5S86_RS21745	COG2917	probably involved in intracellular septation
I5S86_RS21750	COG2350	Protein conserved in bacteria
I5S86_RS21755	COG0745	RESPONSE REGULATOR receiver
I5S86_RS21770	COG0778	Nitroreductase
I5S86_RS21775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5S86_RS21810	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5S86_RS21830	COG2832	Protein of unknown function (DUF454)
I5S86_RS21845	COG2274	protein secretion by the type I secretion system
I5S86_RS21850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5S86_RS21865	COG3148	PFAM DTW domain containing protein
I5S86_RS21870	COG0840	transmembrane signaling receptor activity
I5S86_RS21885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5S86_RS21890	COG0583	DNA-binding transcription factor activity
I5S86_RS21900	COG0697	spore germination
I5S86_RS21925	COG3192	ethanolamine utilization protein
I5S86_RS21940	COG0513	Belongs to the DEAD box helicase family
I5S86_RS21945	COG0668	transmembrane transport
I5S86_RS21950	COG0679	Auxin Efflux Carrier
I5S86_RS21960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I5S86_RS21975	COG2267	carboxylic ester hydrolase activity
I5S86_RS21985	COG1132	(ABC) transporter
I5S86_RS21995	COG2188	Transcriptional regulator
I5S86_RS22005	COG1643	Atp-dependent helicase
I5S86_RS22010	COG0174	glutamine synthetase
I5S86_RS22015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS22020	COG0318	PFAM AMP-dependent synthetase and ligase
I5S86_RS22030	COG2267	carboxylic ester hydrolase activity
I5S86_RS22035	COG2030	dehydratase
I5S86_RS22040	COG4941	Belongs to the sigma-70 factor family
I5S86_RS22050	COG3795	YCII-related domain
I5S86_RS22090	COG0242	peptide deformylase activity
I5S86_RS22095	COG1295	ribonuclease BN
I5S86_RS22105	COG3420	alginic acid biosynthetic process
I5S86_RS22125	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I5S86_RS22155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5S86_RS22175	COG1984	allophanate hydrolase subunit 2
I5S86_RS22180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5S86_RS22185	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I5S86_RS22190	COG2814	Major facilitator Superfamily
I5S86_RS22205	COG0121	glutamine amidotransferase
I5S86_RS22250	COG2983	Belongs to the UPF0260 family
I5S86_RS22255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5S86_RS22260	COG3100	YcgL domain-containing protein
I5S86_RS22280	COG0626	cystathionine gamma-synthase activity
I5S86_RS22285	COG1522	sequence-specific DNA binding
I5S86_RS22290	COG0243	molybdopterin cofactor binding
I5S86_RS22295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I5S86_RS22300	COG3781	membrane
I5S86_RS22305	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5S86_RS22320	COG0531	amino acid
I5S86_RS22325	COG3938	Belongs to the proline racemase family
I5S86_RS22345	COG1902	pentaerythritol trinitrate reductase activity
I5S86_RS22350	COG0640	Transcriptional regulator
I5S86_RS22355	COG0579	oxidoreductase
I5S86_RS22370	COG1609	Transcriptional regulator
I5S86_RS22390	COG3328	transposase activity
I5S86_RS22410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I5S86_RS22415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5S86_RS22420	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I5S86_RS22425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5S86_RS22435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5S86_RS22445	COG0425	Belongs to the sulfur carrier protein TusA family
I5S86_RS22450	COG4783	chaperone-mediated protein folding
I5S86_RS22455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I5S86_RS22460	COG5339	Protein conserved in bacteria
I5S86_RS22465	COG0531	amino acid
I5S86_RS22470	COG0840	transmembrane signaling receptor activity
I5S86_RS22485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I5S86_RS22490	COG0602	queuosine metabolic process
I5S86_RS22495	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I5S86_RS22500	COG2885	chlorophyll binding
I5S86_RS22505	COG0823	Involved in the tonB-independent uptake of proteins
I5S86_RS22525	COG0824	Thioesterase
I5S86_RS22530	COG2255	four-way junction helicase activity
I5S86_RS22535	COG0632	four-way junction helicase activity
I5S86_RS22540	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I5S86_RS22545	COG0217	transcriptional regulatory protein
I5S86_RS22550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I5S86_RS22565	COG0783	Belongs to the Dps family
I5S86_RS22575	COG2900	Belongs to the SlyX family
I5S86_RS22590	COG0442	prolyl-tRNA aminoacylation
I5S86_RS22600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5S86_RS22630	COG3158	transport of potassium into the cell
I5S86_RS22635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5S86_RS22650	COG4807	Protein conserved in bacteria
I5S86_RS22665	COG0583	DNA-binding transcription factor activity
I5S86_RS22680	COG3148	PFAM DTW domain containing protein
I5S86_RS22705	COG2137	regulation of response to DNA damage stimulus
I5S86_RS22710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I5S86_RS22775	COG1247	-acetyltransferase
I5S86_RS22780	COG1473	amidohydrolase
I5S86_RS22785	COG0251	oxidation-reduction process
I5S86_RS22790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS22795	COG0477	Major facilitator Superfamily
I5S86_RS22800	COG0006	proline dipeptidase activity
I5S86_RS22805	COG2423	ornithine cyclodeaminase activity
I5S86_RS22810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5S86_RS22815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5S86_RS22825	COG0765	amino acid transport
I5S86_RS22830	COG0765	amino acid transport
I5S86_RS22835	COG1126	abc transporter atp-binding protein
I5S86_RS22840	COG1522	sequence-specific DNA binding
I5S86_RS22845	COG3608	succinylglutamate desuccinylase aspartoacylase
I5S86_RS22855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5S86_RS22970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I5S86_RS22975	COG1546	Belongs to the CinA family
I5S86_RS22990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I5S86_RS22995	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I5S86_RS23010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I5S86_RS23015	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I5S86_RS23020	COG0585	pseudouridine synthase activity
I5S86_RS23025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I5S86_RS23035	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I5S86_RS23045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I5S86_RS23055	COG0148	phosphopyruvate hydratase activity
I5S86_RS23060	COG0504	CTP synthase activity
I5S86_RS23065	COG0037	tRNA processing
I5S86_RS23070	COG0825	malonyl-CoA metabolic process
I5S86_RS23080	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I5S86_RS23085	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5S86_RS23090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5S86_RS23095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5S86_RS23100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5S86_RS23120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I5S86_RS23130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I5S86_RS23135	COG0233	cytoplasmic translational termination
I5S86_RS23140	COG0528	UMP kinase activity
I5S86_RS23145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I5S86_RS23150	COG0052	Belongs to the universal ribosomal protein uS2 family
I5S86_RS23155	COG0024	Methionine aminopeptidase
I5S86_RS23160	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I5S86_RS23165	COG0436	Aminotransferase
I5S86_RS23170	COG0025	NhaP-type Na H and K H
I5S86_RS23175	COG1393	Belongs to the ArsC family
I5S86_RS23180	COG2171	N-acyltransferase activity
I5S86_RS23185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5S86_RS23190	COG2166	iron-sulfur cluster assembly
I5S86_RS23195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5S86_RS23200	COG1215	transferase activity, transferring glycosyl groups
I5S86_RS23205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5S86_RS23210	COG2226	methyltransferase
I5S86_RS23225	COG2937	Belongs to the GPAT DAPAT family
I5S86_RS23260	COG0742	ribosomal rna small subunit methyltransferase
I5S86_RS23280	COG1801	Protein of unknown function DUF72
I5S86_RS23295	COG0563	adenylate kinase activity
I5S86_RS23300	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I5S86_RS23315	COG2885	chlorophyll binding
I5S86_RS23325	COG1073	alpha beta
I5S86_RS23345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I5S86_RS23355	COG3706	GGDEF domain
I5S86_RS23355	COG5001	Diguanylate cyclase
I5S86_RS23355	COG4251	negative regulation of phosphorylation
I5S86_RS23355	COG2203	Gaf domain
I5S86_RS23360	COG2201	protein-glutamate methylesterase activity
I5S86_RS23375	COG0457	Tetratricopeptide repeat
I5S86_RS23375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5S86_RS23385	COG0840	transmembrane signaling receptor activity
I5S86_RS23390	COG2979	Protein of unknown function (DUF533)
I5S86_RS23395	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS23410	COG1902	pentaerythritol trinitrate reductase activity
I5S86_RS23435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5S86_RS23470	COG4974	Belongs to the 'phage' integrase family
I5S86_RS23480	COG1607	acyl-coa hydrolase
I5S86_RS23485	COG0335	large ribosomal subunit rRNA binding
I5S86_RS23490	COG0336	Belongs to the RNA methyltransferase TrmD family
I5S86_RS23495	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I5S86_RS23500	COG0228	four-way junction DNA binding
I5S86_RS23505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5S86_RS23515	COG4536	flavin adenine dinucleotide binding
I5S86_RS23520	COG0477	Major facilitator Superfamily
I5S86_RS23525	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I5S86_RS23545	COG0494	nUDIX hydrolase
I5S86_RS23595	COG4970	Tfp pilus assembly protein FimT
I5S86_RS23610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5S86_RS23645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5S86_RS23660	COG0047	phosphoribosylformylglycinamidine synthase activity
I5S86_RS23660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5S86_RS23665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5S86_RS23670	COG0590	tRNA wobble adenosine to inosine editing
I5S86_RS23685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5S86_RS23685	COG0519	Catalyzes the synthesis of GMP from XMP
I5S86_RS23700	COG1570	exodeoxyribonuclease VII activity
I5S86_RS23705	COG0739	heme binding
I5S86_RS23710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5S86_RS23740	COG2084	Dehydrogenase
I5S86_RS23755	COG0800	Aldolase
I5S86_RS23770	COG1737	Transcriptional regulator
I5S86_RS23775	COG0676	glucose-6-phosphate 1-epimerase activity
I5S86_RS23785	COG3842	ATPase activity
I5S86_RS23795	COG1175	transmembrane transport
I5S86_RS23800	COG1653	transport
I5S86_RS23835	COG1595	DNA-templated transcription, initiation
I5S86_RS23855	COG2832	Protein of unknown function (DUF454)
I5S86_RS23870	COG2235	arginine
I5S86_RS23875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I5S86_RS23895	COG0509	glycine decarboxylation via glycine cleavage system
I5S86_RS23900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5S86_RS23900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5S86_RS23905	COG1760	l-serine dehydratase
I5S86_RS23910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I5S86_RS23915	COG1278	Cold shock
I5S86_RS23925	COG0795	lipopolysaccharide-transporting ATPase activity
I5S86_RS23930	COG0795	lipopolysaccharide-transporting ATPase activity
I5S86_RS23935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I5S86_RS23950	COG0525	valine-tRNA ligase activity
I5S86_RS23955	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I5S86_RS23960	COG0776	regulation of translation
I5S86_RS23965	COG3081	Nucleoid-associated protein
I5S86_RS23970	COG2827	Endonuclease containing a URI domain
I5S86_RS23980	COG2807	transmembrane transport
I5S86_RS23985	COG2186	Transcriptional regulator
I5S86_RS23990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5S86_RS23995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I5S86_RS24000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I5S86_RS24005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5S86_RS24025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5S86_RS24030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5S86_RS24035	COG1127	ABC transporter
I5S86_RS24045	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5S86_RS24055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I5S86_RS24060	COG1137	ATPase activity
I5S86_RS24065	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I5S86_RS24070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5S86_RS24080	COG1660	Displays ATPase and GTPase activities
I5S86_RS24085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5S86_RS24115	COG0312	modulator of DNA gyrase
I5S86_RS24120	COG3028	Belongs to the UPF0307 family
I5S86_RS24125	COG0312	modulator of DNA gyrase
I5S86_RS24130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5S86_RS24145	COG0424	maF-like protein
I5S86_RS24155	COG1792	Involved in formation and maintenance of cell shape
I5S86_RS24160	COG1077	Cell shape determining protein MreB Mrl
I5S86_RS24165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5S86_RS24170	COG0154	amidase activity
I5S86_RS24175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5S86_RS24190	COG1113	amino acid transport
I5S86_RS24200	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I5S86_RS24215	COG0747	negative chemotaxis
I5S86_RS24220	COG0747	negative chemotaxis
I5S86_RS24230	COG0747	negative chemotaxis
I5S86_RS24235	COG0601	transmembrane transport
I5S86_RS24240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5S86_RS24245	COG0444	Belongs to the ABC transporter superfamily
I5S86_RS24250	COG4608	Belongs to the ABC transporter superfamily
I5S86_RS24265	COG0723	plastoquinol--plastocyanin reductase activity
I5S86_RS24265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS24280	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I5S86_RS24285	COG1396	sequence-specific DNA binding
I5S86_RS24290	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I5S86_RS24315	COG4772	TonB-dependent receptor
I5S86_RS24320	COG3712	iron ion homeostasis
I5S86_RS24330	COG0019	diaminopimelate decarboxylase activity
I5S86_RS24340	COG3128	pkhd-type hydroxylase
I5S86_RS24345	COG4774	siderophore transport
I5S86_RS24350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I5S86_RS24355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5S86_RS24360	COG0436	Aminotransferase
I5S86_RS24365	COG1160	GTP binding
I5S86_RS24380	COG0124	histidyl-tRNA synthetase
I5S86_RS24385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I5S86_RS24400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I5S86_RS24405	COG0105	UTP biosynthetic process
I5S86_RS24415	COG0633	Ferredoxin
I5S86_RS24420	COG0443	Heat shock 70 kDa protein
I5S86_RS24425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5S86_RS24430	COG0316	Belongs to the HesB IscA family
I5S86_RS24440	COG1104	cysteine desulfurase activity
I5S86_RS24450	COG1045	serine acetyltransferase
I5S86_RS24465	COG3134	Outer membrane lipoprotein
I5S86_RS24480	COG1862	Preprotein translocase
I5S86_RS24485	COG0343	queuine tRNA-ribosyltransferase activity
I5S86_RS24490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I5S86_RS24510	COG3781	membrane
I5S86_RS24515	COG3639	organic phosphonate transmembrane transporter activity
I5S86_RS24520	COG3639	organic phosphonate transmembrane transporter activity
I5S86_RS24525	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I5S86_RS24530	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I5S86_RS24535	COG0709	Synthesizes selenophosphate from selenide and ATP
I5S86_RS24540	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I5S86_RS24570	COG0727	PFAM Uncharacterised protein family (UPF0153)
I5S86_RS24575	COG0436	Aminotransferase
I5S86_RS24580	COG0109	protoheme IX farnesyltransferase activity
I5S86_RS24585	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5S86_RS24590	COG1845	cytochrome c oxidase, subunit III
I5S86_RS24595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5S86_RS24600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5S86_RS24605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I5S86_RS24610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5S86_RS24610	COG1017	nitric oxide dioxygenase activity
I5S86_RS24615	COG3604	Transcriptional regulator
I5S86_RS24635	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
I5S86_RS24680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5S86_RS24705	COG4251	negative regulation of phosphorylation
I5S86_RS24705	COG3706	GGDEF domain
I5S86_RS24705	COG2203	Gaf domain
I5S86_RS24705	COG5001	Diguanylate cyclase
I5S86_RS24715	COG3530	Putative quorum-sensing-regulated virulence factor
I5S86_RS24720	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5S86_RS24720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5S86_RS24720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5S86_RS24725	COG1105	Belongs to the carbohydrate kinase PfkB family
I5S86_RS24735	COG1609	Transcriptional regulator
I5S86_RS24740	COG0084	hydrolase, TatD family'
I5S86_RS24745	COG0840	transmembrane signaling receptor activity
I5S86_RS24755	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5S86_RS24770	COG0492	ferredoxin-NADP+ reductase activity
I5S86_RS24775	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I5S86_RS24795	COG0386	Belongs to the glutathione peroxidase family
I5S86_RS24810	COG0280	phosphate acetyltransferase
I5S86_RS24810	COG0857	belongs to the CobB CobQ family
I5S86_RS24815	COG2885	chlorophyll binding
I5S86_RS24820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5S86_RS24850	COG0318	PFAM AMP-dependent synthetase and ligase
I5S86_RS24855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5S86_RS24860	COG2813	Specifically methylates the guanine in position
I5S86_RS24865	COG2119	membrane
I5S86_RS24870	COG0501	Belongs to the peptidase M48B family
I5S86_RS24875	COG2135	peptidase activity
I5S86_RS24915	COG0579	oxidoreductase
I5S86_RS24935	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I5S86_RS24940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I5S86_RS24950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I5S86_RS24955	COG1090	epimerase
I5S86_RS24960	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I5S86_RS24965	COG3272	Protein of unknown function (DUF1722)
I5S86_RS24970	COG0789	Transcriptional regulator
I5S86_RS24980	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS24990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I5S86_RS24995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5S86_RS25005	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I5S86_RS25010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I5S86_RS25020	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I5S86_RS25025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I5S86_RS25035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I5S86_RS25040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I5S86_RS25045	COG0193	aminoacyl-tRNA hydrolase activity
I5S86_RS25075	COG0628	permease
I5S86_RS25090	COG1335	isochorismatase
I5S86_RS25120	COG1511	domain protein
I5S86_RS25120	COG3264	Mechanosensitive ion channel
I5S86_RS25125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5S86_RS25125	COG2169	Transcriptional regulator
I5S86_RS25135	COG1595	DNA-templated transcription, initiation
I5S86_RS25160	COG2223	nitrite transmembrane transporter activity
I5S86_RS25180	COG0456	acetyltransferase
I5S86_RS25205	COG3045	CreA protein
I5S86_RS25210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I5S86_RS25215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I5S86_RS25220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I5S86_RS25225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I5S86_RS25230	COG0142	geranyltranstransferase activity
I5S86_RS25235	COG2824	Alkylphosphonate utilization operon protein PhnA
I5S86_RS25245	COG0545	Peptidyl-prolyl cis-trans isomerase
I5S86_RS25255	COG2862	Uncharacterized protein family, UPF0114
I5S86_RS25265	COG1067	ATP-dependent peptidase activity
I5S86_RS25280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5S86_RS25285	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5S86_RS25290	COG0488	(ABC) transporter
I5S86_RS25305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I5S86_RS25325	COG1846	Transcriptional regulator
I5S86_RS25330	COG0596	Alpha beta hydrolase
I5S86_RS25335	COG2807	transmembrane transport
I5S86_RS25340	COG2963	transposase activity
I5S86_RS25350	COG2433	Pfam Transposase IS66
I5S86_RS25355	COG0456	acetyltransferase
I5S86_RS25375	COG3012	SEC-C Motif Domain Protein
I5S86_RS25400	COG0582	viral genome integration into host DNA
I5S86_RS25425	COG0237	dephospho-CoA kinase activity
I5S86_RS25430	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I5S86_RS25450	COG1252	NADH dehydrogenase
I5S86_RS25470	COG0542	response to heat
I5S86_RS25495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5S86_RS25525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I5S86_RS25530	COG1047	Peptidyl-prolyl cis-trans
I5S86_RS25535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I5S86_RS25540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I5S86_RS25545	COG0196	riboflavin kinase activity
I5S86_RS25555	COG0268	Binds directly to 16S ribosomal RNA
I5S86_RS25560	COG3008	intermembrane lipid transfer
I5S86_RS25565	COG2995	paraquat-inducible protein a
I5S86_RS25570	COG2995	paraquat-inducible protein a
I5S86_RS25615	COG1309	transcriptional regulator
I5S86_RS25625	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS25630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I5S86_RS25640	COG2814	Major facilitator Superfamily
I5S86_RS25645	COG2217	Heavy metal translocating P-type atpase
I5S86_RS25655	COG2217	Heavy metal translocating P-type atpase
I5S86_RS25665	COG0840	transmembrane signaling receptor activity
I5S86_RS25670	COG2207	Transcriptional regulator
I5S86_RS25680	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS25695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5S86_RS25725	COG4953	penicillin-binding protein 1C
I5S86_RS25735	COG2373	Large extracellular alpha-helical protein
I5S86_RS25740	COG0534	Mate efflux family protein
I5S86_RS25750	COG1166	arginine decarboxylase activity
I5S86_RS25755	COG0023	Translation Initiation Factor
I5S86_RS25785	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I5S86_RS25800	COG2264	protein methyltransferase activity
I5S86_RS25810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5S86_RS25820	COG0138	bifunctional purine biosynthesis protein purh
I5S86_RS25825	COG0151	Belongs to the GarS family
I5S86_RS25835	COG2095	MarC family integral membrane protein
I5S86_RS25855	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5S86_RS25865	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I5S86_RS25890	COG0330	HflC and HflK could
I5S86_RS25910	COG4774	siderophore transport
I5S86_RS25920	COG1113	amino acid transport
I5S86_RS25940	COG0411	ABC transporter
I5S86_RS25955	COG0789	Transcriptional regulator
I5S86_RS25960	COG0484	heat shock protein binding
I5S86_RS25965	COG0443	Heat shock 70 kDa protein
I5S86_RS25985	COG0697	spore germination
I5S86_RS25990	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I5S86_RS26005	COG2982	Protein involved in outer membrane biogenesis
I5S86_RS26030	COG4221	oxidoreductase activity
I5S86_RS26060	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5S86_RS26065	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I5S86_RS26075	COG1032	radical SAM domain protein
I5S86_RS26080	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I5S86_RS26085	COG0305	Participates in initiation and elongation during chromosome replication
I5S86_RS26090	COG0359	binds to the 23S rRNA
I5S86_RS26100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5S86_RS26105	COG0360	Binds together with S18 to 16S ribosomal RNA
I5S86_RS26110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5S86_RS26115	COG0557	exoribonuclease II activity
I5S86_RS26130	COG1840	ABC-type Fe3 transport system, periplasmic component
I5S86_RS26135	COG1178	ABC-type Fe3 transport system permease component
I5S86_RS26155	COG0840	transmembrane signaling receptor activity
I5S86_RS26160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I5S86_RS26165	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I5S86_RS26170	COG0330	HflC and HflK could
I5S86_RS26175	COG0330	HflC and HflK could
I5S86_RS26180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5S86_RS26185	COG1923	regulation of RNA biosynthetic process
I5S86_RS26190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I5S86_RS26195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I5S86_RS26200	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5S86_RS26205	COG0802	atpase or kinase
I5S86_RS26210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I5S86_RS26210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5S86_RS26220	COG2860	membrane
I5S86_RS26225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I5S86_RS26230	COG1162	GTPase activity
I5S86_RS26260	COG0688	phosphatidylethanolamine metabolic process
I5S86_RS26265	COG0560	Phosphoserine phosphatase
I5S86_RS26265	COG3830	Belongs to the UPF0237 family
I5S86_RS26285	COG3577	Aspartyl protease
I5S86_RS26300	COG3150	esterase
I5S86_RS26305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5S86_RS26315	COG0494	nUDIX hydrolase
I5S86_RS26330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I5S86_RS26335	COG1538	Outer membrane efflux protein
I5S86_RS26340	COG1773	rubredoxin
I5S86_RS26355	COG0475	glutathione-regulated potassium exporter activity
I5S86_RS26390	COG0629	single-stranded DNA binding
I5S86_RS26395	COG2814	Major facilitator Superfamily
I5S86_RS26400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5S86_RS26405	COG2193	ferroxidase activity
I5S86_RS26410	COG0753	catalase activity
I5S86_RS26415	COG0203	ribosomal protein L17
I5S86_RS26420	COG0202	RNA polymerase activity
I5S86_RS26425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I5S86_RS26430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I5S86_RS26435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I5S86_RS26440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I5S86_RS26450	COG0200	Binds to the 23S rRNA
I5S86_RS26455	COG1841	ribosomal large subunit assembly
I5S86_RS26460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I5S86_RS26465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I5S86_RS26470	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I5S86_RS26475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I5S86_RS26480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5S86_RS26485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I5S86_RS26490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I5S86_RS26495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I5S86_RS26500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I5S86_RS26505	COG0255	Belongs to the universal ribosomal protein uL29 family
I5S86_RS26510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5S86_RS26515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I5S86_RS26520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I5S86_RS26525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5S86_RS26530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I5S86_RS26535	COG0089	rRNA binding
I5S86_RS26540	COG0088	Forms part of the polypeptide exit tunnel
I5S86_RS26545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I5S86_RS26550	COG0051	transcription antitermination factor activity, RNA binding
I5S86_RS26555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5S86_RS26560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5S86_RS26565	COG0049	tRNA binding
I5S86_RS26570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I5S86_RS26575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I5S86_RS26580	COG0085	RNA polymerase activity
I5S86_RS26590	COG0222	ribosome binding
I5S86_RS26595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I5S86_RS26600	COG0081	regulation of translation
I5S86_RS26605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I5S86_RS26625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5S86_RS26650	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I5S86_RS26655	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I5S86_RS26655	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I5S86_RS26675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I5S86_RS26680	COG0739	heme binding
I5S86_RS26685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I5S86_RS26690	COG0316	Belongs to the HesB IscA family
I5S86_RS26695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5S86_RS26700	COG1981	membrane
I5S86_RS26705	COG2070	2-Nitropropane dioxygenase
I5S86_RS26710	COG0300	oxidoreductase activity
I5S86_RS26715	COG0537	adenosine 5'-monophosphoramidase activity
I5S86_RS26720	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I5S86_RS26730	COG1765	OsmC-like protein
I5S86_RS26745	COG0134	indole-3-glycerol-phosphate synthase activity
I5S86_RS26750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5S86_RS26755	COG0512	Glutamine amidotransferase of anthranilate synthase
I5S86_RS26760	COG3240	lipase activity
I5S86_RS26760	COG4625	pathogenesis
I5S86_RS26765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5S86_RS26770	COG0546	phosphoglycolate phosphatase activity
I5S86_RS26775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5S86_RS26780	COG1177	transmembrane transport
I5S86_RS26785	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5S86_RS26795	COG3842	ATPase activity
I5S86_RS26800	COG2197	response regulator
I5S86_RS26815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5S86_RS26820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I5S86_RS26825	COG3178	'Phosphotransferase
I5S86_RS26830	COG3344	reverse transcriptase
I5S86_RS26835	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I5S86_RS26840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5S86_RS26845	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5S86_RS26850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I5S86_RS26855	COG2967	ApaG domain
I5S86_RS26860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5S86_RS26865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5S86_RS26870	COG2766	serine protein kinase
I5S86_RS26875	COG2718	Belongs to the UPF0229 family
I5S86_RS26880	COG2719	SpoVR family
I5S86_RS26885	COG0617	tRNA 3'-terminal CCA addition
I5S86_RS26890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5S86_RS26895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5S86_RS26900	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I5S86_RS26905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I5S86_RS26910	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5S86_RS26915	COG0358	DNA primase activity
I5S86_RS26950	COG1484	DNA-dependent DNA replication
I5S86_RS26985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5S86_RS26990	COG1025	Belongs to the peptidase M16 family
I5S86_RS27000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5S86_RS27005	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I5S86_RS27015	COG0535	radical SAM domain protein
I5S86_RS27030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5S86_RS27035	COG0583	DNA-binding transcription factor activity
I5S86_RS27040	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS27045	COG3706	GGDEF domain
I5S86_RS27050	COG1960	acyl-CoA dehydrogenase activity
I5S86_RS27070	COG2226	methyltransferase
I5S86_RS27070	COG1073	alpha beta
I5S86_RS27075	COG0156	8-amino-7-oxononanoate synthase activity
I5S86_RS27080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I5S86_RS27090	COG3585	molybdate ion transport
I5S86_RS27090	COG2005	Transcriptional regulator
I5S86_RS27095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5S86_RS27110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5S86_RS27115	COG2204	response regulator
I5S86_RS27125	COG2176	DNA-directed DNA polymerase activity
I5S86_RS27130	COG1595	DNA-templated transcription, initiation
I5S86_RS27135	COG3712	iron ion homeostasis
I5S86_RS27140	COG4774	siderophore transport
I5S86_RS27180	COG0438	transferase activity, transferring glycosyl groups
I5S86_RS27195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I5S86_RS27215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5S86_RS27225	COG4452	Inner membrane protein CreD
I5S86_RS27230	COG2205	protein histidine kinase activity
I5S86_RS27235	COG0745	RESPONSE REGULATOR receiver
I5S86_RS27245	COG0204	Acyl-transferase
I5S86_RS27275	COG1063	alcohol dehydrogenase
I5S86_RS27305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I5S86_RS27315	COG0840	transmembrane signaling receptor activity
I5S86_RS27335	COG1017	nitric oxide dioxygenase activity
I5S86_RS27335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5S86_RS27345	COG4638	Rieske (2fe-2S)
I5S86_RS27360	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I5S86_RS27365	COG2181	nitrate reductase activity
I5S86_RS27365	COG0247	lactate metabolic process
I5S86_RS27370	COG1902	pentaerythritol trinitrate reductase activity
I5S86_RS27370	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5S86_RS27410	COG3246	L-lysine catabolic process to acetate
I5S86_RS27415	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5S86_RS27440	COG1760	l-serine dehydratase
I5S86_RS27450	COG4176	ABC-type proline glycine betaine transport system permease component
I5S86_RS27455	COG3448	diguanylate cyclase activity
I5S86_RS27455	COG4175	Glycine betaine
I5S86_RS27460	COG0107	imidazoleglycerol-phosphate synthase activity
I5S86_RS27465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I5S86_RS27475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5S86_RS27480	COG0131	Imidazoleglycerol-phosphate dehydratase
I5S86_RS27485	COG2223	nitrite transmembrane transporter activity
I5S86_RS27500	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I5S86_RS27535	COG4215	(ABC) transporter
I5S86_RS27580	COG0582	viral genome integration into host DNA
I5S86_RS27610	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I5S86_RS27620	COG0069	glutamate synthase activity
I5S86_RS27640	COG2957	Belongs to the agmatine deiminase family
I5S86_RS27645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5S86_RS27675	COG1218	3'(2'),5'-bisphosphate nucleotidase
I5S86_RS27680	COG0494	nUDIX hydrolase
I5S86_RS27685	COG1011	Hydrolase
I5S86_RS27690	COG1652	LysM domain
I5S86_RS27695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I5S86_RS27700	COG0243	molybdopterin cofactor binding
I5S86_RS27725	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I5S86_RS27730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I5S86_RS27740	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5S86_RS27745	COG4067	protein conserved in archaea
I5S86_RS27745	COG0189	ligase activity
I5S86_RS27750	COG0189	ligase activity
I5S86_RS27765	COG2183	response to ionizing radiation
I5S86_RS27775	COG2918	glutathione biosynthetic process
I5S86_RS27790	COG1116	anion transmembrane transporter activity
I5S86_RS27795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5S86_RS27800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5S86_RS27805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5S86_RS27810	COG0450	alkyl hydroperoxide reductase
I5S86_RS27820	COG4521	taurine ABC transporter
I5S86_RS27825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I5S86_RS27830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5S86_RS27835	COG2175	clavaminate synthase activity
I5S86_RS27840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5S86_RS27845	COG1045	serine acetyltransferase
I5S86_RS27850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5S86_RS27855	COG0765	amino acid transport
I5S86_RS27860	COG1126	abc transporter atp-binding protein
I5S86_RS27875	COG2199	diguanylate cyclase activity
I5S86_RS27890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5S86_RS27895	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS27900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5S86_RS27910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5S86_RS27910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5S86_RS27915	COG0509	glycine decarboxylation via glycine cleavage system
I5S86_RS27920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I5S86_RS27925	COG1178	ABC-type Fe3 transport system permease component
I5S86_RS27935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5S86_RS27945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5S86_RS27950	COG0006	proline dipeptidase activity
I5S86_RS27955	COG3079	Belongs to the UPF0149 family
I5S86_RS27975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5S86_RS28010	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5S86_RS28025	COG0248	Ppx GppA phosphatase
I5S86_RS28030	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I5S86_RS28040	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I5S86_RS28045	COG1671	Belongs to the UPF0178 family
I5S86_RS28070	COG1566	PFAM secretion protein HlyD family protein
I5S86_RS28080	COG1289	transmembrane transporter activity
I5S86_RS28110	COG2175	clavaminate synthase activity
I5S86_RS28205	COG1045	serine acetyltransferase
I5S86_RS28220	COG2610	gluconate transmembrane transporter activity
I5S86_RS28230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5S86_RS28235	COG3048	D-serine ammonia-lyase activity
I5S86_RS28255	COG1012	belongs to the aldehyde dehydrogenase family
I5S86_RS28280	COG1028	Short-chain dehydrogenase reductase Sdr
I5S86_RS28320	COG4974	Belongs to the 'phage' integrase family
I5S86_RS28400	COG1110	DNA topoisomerase II activity
I5S86_RS28520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5S86_RS28620	COG1192	Involved in chromosome partitioning
I5S86_RS28625	COG1475	DNA binding
I5S86_RS28750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5S86_RS28765	COG2203	Gaf domain
I5S86_RS28765	COG3706	GGDEF domain
I5S86_RS28765	COG5001	Diguanylate cyclase
I5S86_RS28765	COG4251	negative regulation of phosphorylation
I5S86_RS28820	COG0305	Participates in initiation and elongation during chromosome replication
I5S86_RS28885	COG2974	May be involved in recombination