locus-tag	class	description
CR091_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CR091_RS00010	COG0592	DNA-directed DNA polymerase activity
CR091_RS00015	COG2501	S4 domain
CR091_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CR091_RS00025	COG0187	DNA topoisomerase II activity
CR091_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CR091_RS00065	COG0517	IMP dehydrogenase activity
CR091_RS00065	COG0516	GMP reductase activity
CR091_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CR091_RS00095	COG1428	Deoxynucleoside kinase
CR091_RS00100	COG1428	Deoxynucleoside kinase
CR091_RS00105	COG1388	LysM domain
CR091_RS00105	COG3858	chitin binding
CR091_RS00110	COG1335	isochorismatase
CR091_RS00115	COG0590	tRNA wobble adenosine to inosine editing
CR091_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CR091_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CR091_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CR091_RS00240	COG1982	Orn Lys Arg decarboxylase major
CR091_RS00245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CR091_RS00250	COG3870	Protein conserved in bacteria
CR091_RS00255	COG0470	DNA polymerase III
CR091_RS00260	COG1774	PSP1 C-terminal conserved region
CR091_RS00265	COG4467	Involved in initiation control of chromosome replication
CR091_RS00270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CR091_RS00275	COG2827	Endonuclease containing a URI domain
CR091_RS00280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CR091_RS00285	COG2002	toxin-antitoxin pair type II binding
CR091_RS00295	COG0084	hydrolase, TatD family'
CR091_RS00305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CR091_RS00315	COG4466	Protein conserved in bacteria
CR091_RS00330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CR091_RS00335	COG0251	oxidation-reduction process
CR091_RS00340	COG2088	sporulation resulting in formation of a cellular spore
CR091_RS00345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CR091_RS00355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CR091_RS00360	COG0193	aminoacyl-tRNA hydrolase activity
CR091_RS00370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CR091_RS00375	COG2002	toxin-antitoxin pair type II binding
CR091_RS00380	COG2244	polysaccharide biosynthetic process
CR091_RS00385	COG3956	TIGRFAM MazG family protein
CR091_RS00390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CR091_RS00405	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CR091_RS00410	COG1098	S1 RNA binding domain
CR091_RS00430	COG2304	oxidoreductase activity
CR091_RS00435	COG0515	serine threonine protein kinase
CR091_RS00440	COG0037	tRNA processing
CR091_RS00445	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CR091_RS00450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CR091_RS00455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CR091_RS00460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CR091_RS00465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CR091_RS00470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CR091_RS00475	COG0512	Glutamine amidotransferase of anthranilate synthase
CR091_RS00480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CR091_RS00485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CR091_RS00490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CR091_RS00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CR091_RS00520	COG3880	PFAM UvrB UvrC protein
CR091_RS00525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CR091_RS00530	COG0542	response to heat
CR091_RS00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CR091_RS00540	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CR091_RS00545	COG4956	integral membrane protein (PIN domain superfamily)
CR091_RS00550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CR091_RS00560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CR091_RS00565	COG1045	serine acetyltransferase
CR091_RS00570	COG0215	cysteine-tRNA ligase activity
CR091_RS00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CR091_RS00585	COG3688	RNA-binding protein containing a PIN domain
CR091_RS00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CR091_RS00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CR091_RS00605	COG0250	Participates in transcription elongation, termination and antitermination
CR091_RS00610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CR091_RS00615	COG0081	regulation of translation
CR091_RS00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CR091_RS00625	COG0222	ribosome binding
CR091_RS00635	COG0085	RNA polymerase activity
CR091_RS00640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CR091_RS00645	COG1358	cellular component organization or biogenesis
CR091_RS00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CR091_RS00655	COG0049	tRNA binding
CR091_RS00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CR091_RS00670	COG0051	transcription antitermination factor activity, RNA binding
CR091_RS00675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CR091_RS00680	COG0088	Forms part of the polypeptide exit tunnel
CR091_RS00685	COG0089	rRNA binding
CR091_RS00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CR091_RS00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CR091_RS00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CR091_RS00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CR091_RS00715	COG0255	Belongs to the universal ribosomal protein uL29 family
CR091_RS00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CR091_RS00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CR091_RS00740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CR091_RS00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CR091_RS00760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CR091_RS00765	COG1841	ribosomal large subunit assembly
CR091_RS00775	COG0201	protein transport
CR091_RS00780	COG0563	adenylate kinase activity
CR091_RS00785	COG0024	Methionine aminopeptidase
CR091_RS00790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CR091_RS00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CR091_RS00800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CR091_RS00810	COG0202	RNA polymerase activity
CR091_RS00815	COG0203	ribosomal protein L17
CR091_RS00820	COG1122	ATPase activity
CR091_RS00825	COG1122	ATPase activity
CR091_RS00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CR091_RS00835	COG0101	tRNA pseudouridine synthase activity
CR091_RS00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CR091_RS00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
CR091_RS00860	COG0489	protein tyrosine kinase activity
CR091_RS00865	COG0583	DNA-binding transcription factor activity
CR091_RS00875	COG2194	sulfuric ester hydrolase activity
CR091_RS00880	COG0726	polysaccharide deacetylase
CR091_RS00960	COG1595	DNA-templated transcription, initiation
CR091_RS00965	COG5662	AntiSigma factor
CR091_RS00970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CR091_RS00980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CR091_RS00985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CR091_RS01000	COG4991	sh3 domain protein
CR091_RS01000	COG3103	Sh3 type 3 domain protein
CR091_RS01000	COG0860	N-Acetylmuramoyl-L-alanine amidase
CR091_RS01005	COG2213	PTS system mannitol-specific
CR091_RS01005	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CR091_RS01010	COG3711	transcriptional antiterminator
CR091_RS01015	COG0246	Mannitol dehydrogenase
CR091_RS01025	COG1376	ErfK ybiS ycfS ynhG family protein
CR091_RS01030	COG1970	mechanosensitive ion channel activity
CR091_RS01035	COG1368	sulfuric ester hydrolase activity
CR091_RS01055	COG1177	transmembrane transport
CR091_RS01060	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CR091_RS01075	COG5002	protein histidine kinase activity
CR091_RS01090	COG3976	FMN-binding domain protein
CR091_RS01090	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CR091_RS01095	COG1181	Belongs to the D-alanine--D-alanine ligase family
CR091_RS01100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CR091_RS01105	COG0513	Belongs to the DEAD box helicase family
CR091_RS01110	COG4294	response to UV
CR091_RS01115	COG0705	Rhomboid family
CR091_RS01120	COG0736	holo-[acyl-carrier-protein] synthase activity
CR091_RS01125	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CR091_RS01130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CR091_RS01135	COG0864	Transcriptional regulator
CR091_RS01140	COG2337	Toxic component of a toxin-antitoxin (TA) module
CR091_RS01145	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS01150	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS01155	COG2172	sigma factor antagonist activity
CR091_RS01160	COG2208	phosphoserine phosphatase activity
CR091_RS01165	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS01175	COG1191	sigma factor activity
CR091_RS01180	COG2208	phosphoserine phosphatase activity
CR091_RS01185	COG2183	response to ionizing radiation
CR091_RS01280	COG0802	atpase or kinase
CR091_RS01285	COG1214	PFAM Peptidase M22, glycoprotease
CR091_RS01290	COG0456	acetyltransferase
CR091_RS01300	COG0488	(ABC) transporter
CR091_RS01305	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CR091_RS01310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CR091_RS01315	COG0805	protein transport
CR091_RS01325	COG1266	CAAX protease self-immunity
CR091_RS01330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CR091_RS01335	COG0459	protein refolding
CR091_RS01340	COG0714	Associated with various cellular activities
CR091_RS01350	COG1305	Transglutaminase-like
CR091_RS01355	COG0519	Catalyzes the synthesis of GMP from XMP
CR091_RS01355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CR091_RS01360	COG2252	PERMEase
CR091_RS01415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CR091_RS01420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CR091_RS01425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CR091_RS01430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CR091_RS01435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CR091_RS01440	COG0047	phosphoribosylformylglycinamidine synthase activity
CR091_RS01445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CR091_RS01450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CR091_RS01455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CR091_RS01460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CR091_RS01465	COG0138	bifunctional purine biosynthesis protein purh
CR091_RS01470	COG0151	Belongs to the GarS family
CR091_RS01480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CR091_RS01485	COG4496	protein, YerC YecD
CR091_RS01490	COG0423	glycine-tRNA ligase activity
CR091_RS01500	COG0210	DNA helicase
CR091_RS01510	COG4851	CamS sex pheromone cAM373 precursor
CR091_RS01520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CR091_RS01525	COG0154	amidase activity
CR091_RS01535	COG1597	lipid kinase activity
CR091_RS01555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR091_RS01565	COG0166	Belongs to the GPI family
CR091_RS01570	COG1744	ABC transporter substrate-binding protein PnrA-like
CR091_RS01575	COG3852	Histidine kinase
CR091_RS01580	COG0024	Methionine aminopeptidase
CR091_RS01585	COG2706	6-phosphogluconolactonase activity
CR091_RS01595	COG0789	Transcriptional regulator
CR091_RS01595	COG4978	Transcriptional regulator
CR091_RS01600	COG2814	Major facilitator Superfamily
CR091_RS01610	COG1876	peptidase activity
CR091_RS01615	COG1126	abc transporter atp-binding protein
CR091_RS01620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR091_RS01625	COG0765	amino acid transport
CR091_RS01630	COG0765	amino acid transport
CR091_RS01635	COG1113	amino acid transport
CR091_RS01640	COG2733	membrane
CR091_RS01645	COG3212	peptidase
CR091_RS01650	COG3212	peptidase
CR091_RS01655	COG3850	Histidine kinase
CR091_RS01655	COG5002	protein histidine kinase activity
CR091_RS01660	COG0745	RESPONSE REGULATOR receiver
CR091_RS01665	COG2205	protein histidine kinase activity
CR091_RS01670	COG0745	RESPONSE REGULATOR receiver
CR091_RS01675	COG2311	Membrane
CR091_RS01690	COG0671	phosphoesterase, PA-phosphatase related
CR091_RS01695	COG1764	response to oxidative stress
CR091_RS01700	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CR091_RS01710	COG2259	Doxx family
CR091_RS01715	COG0693	protein deglycase activity
CR091_RS01725	COG2318	DinB family
CR091_RS01735	COG1115	amino acid carrier protein
CR091_RS01750	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CR091_RS01755	COG0598	Magnesium transport protein CorA
CR091_RS01760	COG3290	protein histidine kinase activity
CR091_RS01765	COG4565	transcriptional regulatory protein
CR091_RS01780	COG4191	Histidine kinase
CR091_RS01785	COG0513	Belongs to the DEAD box helicase family
CR091_RS01805	COG4842	Belongs to the WXG100 family
CR091_RS01810	COG5417	Belongs to the EsaB family
CR091_RS01815	COG4499	WXG100 protein secretion system (Wss), protein YukC
CR091_RS01820	COG0433	COG0433 Predicted ATPase
CR091_RS01820	COG1674	ftsk spoiiie
CR091_RS01825	COG1511	domain protein
CR091_RS01840	COG2356	endonuclease I
CR091_RS01850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CR091_RS01865	COG0488	(ABC) transporter
CR091_RS01875	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CR091_RS01885	COG1959	2 iron, 2 sulfur cluster binding
CR091_RS01890	COG1017	nitric oxide dioxygenase activity
CR091_RS01890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CR091_RS01900	COG0693	protein deglycase activity
CR091_RS01905	COG2340	Cysteine-rich secretory protein family
CR091_RS01910	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CR091_RS01915	COG4840	Belongs to the UPF0435 family
CR091_RS01920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CR091_RS01925	COG4980	gas vesicle protein
CR091_RS01930	COG1295	ribonuclease BN
CR091_RS01935	COG2217	Heavy metal translocating P-type atpase
CR091_RS01945	COG0640	Transcriptional regulator
CR091_RS01955	COG0477	Major facilitator Superfamily
CR091_RS01965	COG3479	Phenolic acid decarboxylase
CR091_RS01975	COG3871	stress protein (general stress protein 26)
CR091_RS01980	COG0387	Pfam Sodium calcium exchanger
CR091_RS01990	COG0535	radical SAM domain protein
CR091_RS02010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CR091_RS02020	COG1113	amino acid transport
CR091_RS02025	COG5002	protein histidine kinase activity
CR091_RS02045	COG1090	epimerase
CR091_RS02055	COG4221	oxidoreductase activity
CR091_RS02075	COG1988	membrane-bound metal-dependent
CR091_RS02080	COG1194	a g-specific adenine glycosylase
CR091_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS02105	COG3557	Belongs to the UPF0374 family
CR091_RS02110	COG1132	(ABC) transporter
CR091_RS02115	COG4129	membrane
CR091_RS02120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CR091_RS02125	COG4555	ABC transporter
CR091_RS02145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CR091_RS02150	COG0735	belongs to the Fur family
CR091_RS02265	COG3382	B3 4 domain protein
CR091_RS02280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CR091_RS02285	COG2766	serine protein kinase
CR091_RS02300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CR091_RS02305	COG0697	spore germination
CR091_RS02330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CR091_RS02340	COG1968	undecaprenyl-diphosphatase activity
CR091_RS02345	COG1301	dicarboxylic acid transport
CR091_RS02350	COG0628	permease
CR091_RS02355	COG0586	Pfam SNARE associated Golgi protein
CR091_RS02360	COG2217	Heavy metal translocating P-type atpase
CR091_RS02365	COG0531	amino acid
CR091_RS02380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CR091_RS02385	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CR091_RS02390	COG3842	ATPase activity
CR091_RS02395	COG1175	transmembrane transport
CR091_RS02400	COG0395	ABC-type sugar transport system, permease component
CR091_RS02405	COG1653	transport
CR091_RS02410	COG0584	glycerophosphoryl diester phosphodiesterase
CR091_RS02425	COG4948	Mandelate Racemase Muconate Lactonizing
CR091_RS02470	COG1388	LysM domain
CR091_RS02470	COG3584	3D domain protein
CR091_RS02475	COG1876	peptidase activity
CR091_RS02485	COG3103	Sh3 type 3 domain protein
CR091_RS02490	COG0456	acetyltransferase
CR091_RS02490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS02495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CR091_RS02520	COG1609	Transcriptional regulator
CR091_RS02525	COG2814	Major facilitator Superfamily
CR091_RS02530	COG0673	inositol 2-dehydrogenase activity
CR091_RS02555	COG1609	Transcriptional regulator
CR091_RS02560	COG3718	enzyme involved in inositol metabolism
CR091_RS02570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR091_RS02575	COG1522	sequence-specific DNA binding
CR091_RS02605	COG1187	pseudouridine synthase activity
CR091_RS02615	COG1942	4-Oxalocrotonate Tautomerase
CR091_RS02625	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CR091_RS02630	COG0747	negative chemotaxis
CR091_RS02645	COG0084	hydrolase, TatD family'
CR091_RS02650	COG2962	Rard protein
CR091_RS02660	COG0628	permease
CR091_RS02675	COG0604	alcohol dehydrogenase
CR091_RS02680	COG1620	l-lactate permease
CR091_RS02690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CR091_RS02695	COG0840	transmembrane signaling receptor activity
CR091_RS02700	COG0564	pseudouridine synthase activity
CR091_RS02715	COG0673	inositol 2-dehydrogenase activity
CR091_RS02720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CR091_RS02725	COG1376	ErfK ybiS ycfS ynhG family protein
CR091_RS02730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CR091_RS02730	COG3153	acetyltransferase
CR091_RS02735	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CR091_RS02740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CR091_RS02745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CR091_RS02750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CR091_RS02755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CR091_RS02760	COG1268	BioY protein
CR091_RS02770	COG2719	SpoVR family
CR091_RS02780	COG1959	2 iron, 2 sulfur cluster binding
CR091_RS02785	COG0604	alcohol dehydrogenase
CR091_RS02795	COG1126	abc transporter atp-binding protein
CR091_RS02800	COG0765	amino acid transport
CR091_RS02805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR091_RS02810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CR091_RS02815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CR091_RS02825	COG0352	thiamine-phosphate diphosphorylase activity
CR091_RS02830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CR091_RS02845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CR091_RS02850	COG0351	phosphomethylpyrimidine kinase
CR091_RS02865	COG0702	epimerase
CR091_RS02870	COG1253	flavin adenine dinucleotide binding
CR091_RS02885	COG3842	ATPase activity
CR091_RS02890	COG2508	Transcriptional regulator
CR091_RS02905	COG0189	ligase activity
CR091_RS02910	COG0189	ligase activity
CR091_RS02920	COG3679	Belongs to the UPF0342 family
CR091_RS02925	COG0561	phosphatase activity
CR091_RS02930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CR091_RS02935	COG0318	PFAM AMP-dependent synthetase and ligase
CR091_RS02940	COG1024	Enoyl-CoA hydratase
CR091_RS02955	COG4152	abc transporter atp-binding protein
CR091_RS02960	COG1668	transmembrane transport
CR091_RS02970	COG3481	metal-dependent phosphohydrolase, HD sub domain
CR091_RS02980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CR091_RS03005	COG1846	Transcriptional regulator
CR091_RS03025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CR091_RS03030	COG1695	Transcriptional regulator
CR091_RS03035	COG2153	protein acetylation
CR091_RS03040	COG2755	lipolytic protein G-D-S-L family
CR091_RS03040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CR091_RS03045	COG0537	adenosine 5'-monophosphoramidase activity
CR091_RS03050	COG1131	(ABC) transporter
CR091_RS03055	COG4473	ABC transporter
CR091_RS03065	COG1473	amidohydrolase
CR091_RS03070	COG0671	phosphoesterase, PA-phosphatase related
CR091_RS03075	COG3069	C4-dicarboxylate transmembrane transporter activity
CR091_RS03080	COG2329	Antibiotic biosynthesis monooxygenase
CR091_RS03085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CR091_RS03090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CR091_RS03095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CR091_RS03100	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CR091_RS03105	COG1309	transcriptional regulator
CR091_RS03110	COG0768	penicillin binding
CR091_RS03120	COG2972	Histidine kinase
CR091_RS03135	COG1234	tRNA 3'-trailer cleavage
CR091_RS03140	COG0095	Lipoate-protein ligase
CR091_RS03145	COG0318	PFAM AMP-dependent synthetase and ligase
CR091_RS03150	COG1024	Enoyl-CoA hydratase
CR091_RS03265	COG0501	Belongs to the peptidase M48B family
CR091_RS03270	COG2224	Isocitrate lyase
CR091_RS03280	COG1506	peptidase
CR091_RS03280	COG4946	Tricorn protease homolog
CR091_RS03280	COG0823	Involved in the tonB-independent uptake of proteins
CR091_RS03285	COG0398	Pfam SNARE associated Golgi protein
CR091_RS03290	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS03295	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CR091_RS03300	COG1074	ATP-dependent DNA helicase activity
CR091_RS03305	COG0420	3'-5' exonuclease activity
CR091_RS03310	COG0419	ATPase involved in DNA repair
CR091_RS03315	COG1403	HNH endonuclease
CR091_RS03350	COG2311	Membrane
CR091_RS03365	COG0367	asparagine synthase
CR091_RS03380	COG1562	ergosterol biosynthetic process
CR091_RS03385	COG0347	Belongs to the P(II) protein family
CR091_RS03390	COG0004	ammonium transporteR
CR091_RS03395	COG1874	Beta-galactosidase
CR091_RS03395	COG0366	Alpha amylase catalytic
CR091_RS03400	COG1609	Transcriptional regulator
CR091_RS03405	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS03410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CR091_RS03415	COG4187	Peptidase family M20/M25/M40
CR091_RS03420	COG0833	amino acid
CR091_RS03425	COG3829	transcription factor binding
CR091_RS03430	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS03435	COG1666	GTP binding
CR091_RS03440	COG2996	Protein conserved in bacteria
CR091_RS03450	COG1307	EDD domain protein, DegV family
CR091_RS03455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR091_RS03470	COG2151	metal-sulfur cluster biosynthetic enzyme
CR091_RS03475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CR091_RS03480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CR091_RS03485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CR091_RS03490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CR091_RS03510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CR091_RS03525	COG0542	response to heat
CR091_RS03540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CR091_RS03545	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CR091_RS03550	COG2084	Dehydrogenase
CR091_RS03560	COG2267	carboxylic ester hydrolase activity
CR091_RS03580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CR091_RS03585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CR091_RS03590	COG5504	Zn-dependent protease
CR091_RS03595	COG0444	Belongs to the ABC transporter superfamily
CR091_RS03600	COG4608	Belongs to the ABC transporter superfamily
CR091_RS03610	COG0601	transmembrane transport
CR091_RS03625	COG0180	Tryptophanyl-tRNA synthetase
CR091_RS03635	COG4166	transmembrane transport
CR091_RS03640	COG0601	transmembrane transport
CR091_RS03645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CR091_RS03650	COG0444	Belongs to the ABC transporter superfamily
CR091_RS03655	COG4608	Belongs to the ABC transporter superfamily
CR091_RS03660	COG0456	acetyltransferase
CR091_RS03665	COG1113	amino acid transport
CR091_RS03670	COG0531	amino acid
CR091_RS03675	COG1393	Belongs to the ArsC family
CR091_RS03680	COG0583	DNA-binding transcription factor activity
CR091_RS03695	COG0861	Integral membrane protein TerC family
CR091_RS03705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CR091_RS03715	COG1164	Oligoendopeptidase f
CR091_RS03725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CR091_RS03730	COG2346	COG2346, Truncated hemoglobins
CR091_RS03735	COG0741	lytic transglycosylase activity
CR091_RS03740	COG4116	CYTH
CR091_RS03750	COG2357	RelA SpoT domain protein
CR091_RS03760	COG0564	pseudouridine synthase activity
CR091_RS03770	COG2239	Acts as a magnesium transporter
CR091_RS03775	COG0475	glutathione-regulated potassium exporter activity
CR091_RS03775	COG0569	domain protein
CR091_RS03825	COG0210	DNA helicase
CR091_RS03835	COG2323	membrane
CR091_RS03840	COG2153	protein acetylation
CR091_RS03850	COG2382	esterase
CR091_RS03865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CR091_RS03875	COG1737	Transcriptional regulator
CR091_RS03880	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CR091_RS03885	COG1070	Carbohydrate kinase
CR091_RS03890	COG1953	Uracil, thiamine, allantoin
CR091_RS03910	COG1522	sequence-specific DNA binding
CR091_RS03940	COG3142	Participates in the control of copper homeostasis
CR091_RS03945	COG1113	amino acid transport
CR091_RS03955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CR091_RS03960	COG1309	transcriptional regulator
CR091_RS03965	COG3711	transcriptional antiterminator
CR091_RS03965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CR091_RS03970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CR091_RS03975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CR091_RS03980	COG1447	Phosphotransferase system cellobiose-specific component IIA
CR091_RS03985	COG1486	melibiose metabolic process
CR091_RS03990	COG2204	response regulator
CR091_RS04005	COG3275	phosphorelay sensor kinase activity
CR091_RS04010	COG3279	Response regulator of the LytR AlgR family
CR091_RS04020	COG1346	cytolysis
CR091_RS04035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CR091_RS04040	COG0243	molybdopterin cofactor binding
CR091_RS04045	COG2223	nitrite transmembrane transporter activity
CR091_RS04050	COG3527	Alpha-acetolactate decarboxylase
CR091_RS04055	COG0028	Belongs to the TPP enzyme family
CR091_RS04065	COG4895	conserved protein (DUF2196)
CR091_RS04075	COG1733	regulation of RNA biosynthetic process
CR091_RS04080	COG2814	Major facilitator Superfamily
CR091_RS04085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR091_RS04105	COG3052	prosthetic group binding
CR091_RS04120	COG0784	Response regulator, receiver
CR091_RS04125	COG4191	Histidine kinase
CR091_RS04130	COG2066	Belongs to the glutaminase family
CR091_RS04135	COG1115	amino acid carrier protein
CR091_RS04140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CR091_RS04150	COG4297	protein containing double-stranded beta helix domain
CR091_RS04155	COG0531	amino acid
CR091_RS04165	COG1607	acyl-coa hydrolase
CR091_RS04170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CR091_RS04185	COG0390	transport system, permease component
CR091_RS04190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CR091_RS04205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CR091_RS04210	COG1136	(ABC) transporter
CR091_RS04215	COG0577	efflux transmembrane transporter activity
CR091_RS04225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CR091_RS04240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CR091_RS04245	COG0833	amino acid
CR091_RS04255	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CR091_RS04260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CR091_RS04270	COG0861	Integral membrane protein TerC family
CR091_RS04275	COG1301	dicarboxylic acid transport
CR091_RS04280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CR091_RS04285	COG3290	protein histidine kinase activity
CR091_RS04325	COG1476	TRANSCRIPTIONal
CR091_RS04335	COG1368	sulfuric ester hydrolase activity
CR091_RS04350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CR091_RS04355	COG2040	homocysteine
CR091_RS04360	COG0179	Fumarylacetoacetate (FAA) hydrolase
CR091_RS04375	COG2851	Citrate transporter
CR091_RS04380	COG3290	protein histidine kinase activity
CR091_RS04385	COG4565	transcriptional regulatory protein
CR091_RS04390	COG3181	Tripartite tricarboxylate transporter family receptor
CR091_RS04395	COG0583	DNA-binding transcription factor activity
CR091_RS04400	COG3180	Ammonia monooxygenase
CR091_RS04405	COG2226	methyltransferase
CR091_RS04410	COG4176	ABC-type proline glycine betaine transport system permease component
CR091_RS04415	COG0517	IMP dehydrogenase activity
CR091_RS04415	COG4175	Glycine betaine
CR091_RS04420	COG2113	Glycine betaine
CR091_RS04425	COG1309	transcriptional regulator
CR091_RS04430	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS04445	COG0531	amino acid
CR091_RS04450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CR091_RS04465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR091_RS04475	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CR091_RS04480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR091_RS04485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR091_RS04515	COG1737	Transcriptional regulator
CR091_RS04520	COG1263	PTS System
CR091_RS04520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CR091_RS04530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CR091_RS04535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CR091_RS04540	COG1116	anion transmembrane transporter activity
CR091_RS04545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CR091_RS04550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CR091_RS04560	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CR091_RS04565	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CR091_RS04570	COG1733	regulation of RNA biosynthetic process
CR091_RS04605	COG1511	domain protein
CR091_RS04610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CR091_RS04615	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CR091_RS04620	COG1733	regulation of RNA biosynthetic process
CR091_RS04625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CR091_RS04625	COG0604	alcohol dehydrogenase
CR091_RS04625	COG4221	oxidoreductase activity
CR091_RS04625	COG3321	synthase
CR091_RS04630	COG1132	(ABC) transporter
CR091_RS04635	COG1132	(ABC) transporter
CR091_RS04645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CR091_RS04650	COG3162	membrane
CR091_RS04660	COG1414	Transcriptional regulator
CR091_RS04665	COG0656	L-ascorbic acid biosynthetic process
CR091_RS04670	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CR091_RS04675	COG1846	Transcriptional regulator
CR091_RS04680	COG1566	PFAM secretion protein HlyD family protein
CR091_RS04685	COG2814	Major facilitator Superfamily
CR091_RS04690	COG0655	NAD(P)H dehydrogenase (quinone) activity
CR091_RS04705	COG1609	Transcriptional regulator
CR091_RS04710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CR091_RS04720	COG1129	ABC transporter
CR091_RS04725	COG1172	Belongs to the binding-protein-dependent transport system permease family
CR091_RS04730	COG1879	ABC-type sugar transport system periplasmic component
CR091_RS04735	COG3584	3D domain protein
CR091_RS04735	COG1388	LysM domain
CR091_RS04740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CR091_RS04745	COG1653	transport
CR091_RS04790	COG0745	RESPONSE REGULATOR receiver
CR091_RS04795	COG5002	protein histidine kinase activity
CR091_RS04805	COG2267	carboxylic ester hydrolase activity
CR091_RS04820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CR091_RS04835	COG0402	S-adenosylhomocysteine deaminase activity
CR091_RS04840	COG2252	PERMEase
CR091_RS04845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CR091_RS04855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CR091_RS04855	COG1263	PTS System
CR091_RS04860	COG0366	Alpha amylase catalytic
CR091_RS04865	COG2188	Transcriptional regulator
CR091_RS04870	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CR091_RS04875	COG1984	allophanate hydrolase subunit 2
CR091_RS04880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CR091_RS04885	COG1914	H( )-stimulated, divalent metal cation uptake system
CR091_RS04890	COG1272	protein, Hemolysin III
CR091_RS04905	COG0778	Nitroreductase
CR091_RS04910	COG0628	permease
CR091_RS04935	COG0439	Biotin carboxylase
CR091_RS04950	COG0531	amino acid
CR091_RS04955	COG0402	S-adenosylhomocysteine deaminase activity
CR091_RS04965	COG1131	(ABC) transporter
CR091_RS04970	COG1278	Cold shock
CR091_RS04975	COG2910	NAD(P)H-binding
CR091_RS04980	COG0673	inositol 2-dehydrogenase activity
CR091_RS04985	COG0450	alkyl hydroperoxide reductase
CR091_RS04990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CR091_RS05015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CR091_RS05095	COG1649	PFAM Uncharacterised BCR, COG1649
CR091_RS05100	COG1737	Transcriptional regulator
CR091_RS05120	COG1486	melibiose metabolic process
CR091_RS05130	COG1447	Phosphotransferase system cellobiose-specific component IIA
CR091_RS05140	COG2971	BadF BadG BcrA BcrD
CR091_RS05145	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CR091_RS05160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CR091_RS05175	COG1376	ErfK ybiS ycfS ynhG family protein
CR091_RS05180	COG2226	methyltransferase
CR091_RS05185	COG0583	DNA-binding transcription factor activity
CR091_RS05195	COG0667	Aldo Keto reductase
CR091_RS05210	COG0154	amidase activity
CR091_RS05225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CR091_RS05285	COG2200	EAL domain
CR091_RS05285	COG2199	diguanylate cyclase activity
CR091_RS05295	COG1733	regulation of RNA biosynthetic process
CR091_RS05310	COG0385	Bile acid
CR091_RS05320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CR091_RS05330	COG4191	Histidine kinase
CR091_RS05335	COG0784	Response regulator, receiver
CR091_RS05355	COG1388	LysM domain
CR091_RS05355	COG0791	NLP P60 protein
CR091_RS05370	COG0656	L-ascorbic acid biosynthetic process
CR091_RS05385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CR091_RS05390	COG4948	Mandelate Racemase Muconate Lactonizing
CR091_RS05410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CR091_RS05420	COG0477	Major facilitator Superfamily
CR091_RS05425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CR091_RS05435	COG0640	Transcriptional regulator
CR091_RS05440	COG5658	integral membrane protein
CR091_RS05465	COG5001	Diguanylate cyclase
CR091_RS05465	COG3300	MHYT domain
CR091_RS05470	COG0302	gtp cyclohydrolase
CR091_RS05475	COG3634	alkyl hydroperoxide reductase activity
CR091_RS05485	COG3300	MHYT domain
CR091_RS05485	COG5001	Diguanylate cyclase
CR091_RS05490	COG0531	amino acid
CR091_RS05545	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CR091_RS05560	COG2385	sporulation resulting in formation of a cellular spore
CR091_RS05560	COG2247	cell wall binding repeat
CR091_RS05570	COG4464	protein tyrosine phosphatase activity
CR091_RS05575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CR091_RS05580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CR091_RS05590	COG1216	Glycosyl transferase, family 2
CR091_RS05590	COG1442	glycosyl transferase family 8
CR091_RS05600	COG5039	Polysaccharide pyruvyl transferase
CR091_RS05620	COG3944	biosynthesis protein
CR091_RS05625	COG0489	protein tyrosine kinase activity
CR091_RS05635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CR091_RS05645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CR091_RS05660	COG1216	Glycosyl transferase, family 2
CR091_RS05660	COG1442	glycosyl transferase family 8
CR091_RS05675	COG1682	transport, permease protein
CR091_RS05680	COG1134	teichoic acid transport
CR091_RS05690	COG1316	TRANSCRIPTIONal
CR091_RS05700	COG4464	protein tyrosine phosphatase activity
CR091_RS05710	COG0028	Belongs to the TPP enzyme family
CR091_RS05715	COG0069	glutamate synthase activity
CR091_RS05725	COG2084	Dehydrogenase
CR091_RS05755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CR091_RS05760	COG2146	nitrite reductase [NAD(P)H] activity
CR091_RS05770	COG2116	formate transmembrane transporter activity
CR091_RS05780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CR091_RS05785	COG4975	Glucose uptake
CR091_RS05800	COG0534	Mate efflux family protein
CR091_RS05810	COG1316	TRANSCRIPTIONal
CR091_RS05820	COG0598	Magnesium transport protein CorA
CR091_RS05825	COG1404	Belongs to the peptidase S8 family
CR091_RS05845	COG4821	SIS domain
CR091_RS05850	COG2188	Transcriptional regulator
CR091_RS05855	COG0363	glucosamine-6-phosphate deaminase activity
CR091_RS05860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CR091_RS05865	COG2190	(PTS) system
CR091_RS05865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CR091_RS05865	COG1263	PTS System
CR091_RS05870	COG1811	Na channel or pump
CR091_RS05905	COG1131	(ABC) transporter
CR091_RS05910	COG1253	flavin adenine dinucleotide binding
CR091_RS05915	COG0789	Transcriptional regulator
CR091_RS05925	COG0346	lactoylglutathione lyase activity
CR091_RS05930	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CR091_RS05930	COG2105	PFAM AIG2 family protein
CR091_RS05960	COG0840	transmembrane signaling receptor activity
CR091_RS05965	COG0456	acetyltransferase
CR091_RS05970	COG1473	amidohydrolase
CR091_RS05980	COG4187	Peptidase family M20/M25/M40
CR091_RS05995	COG0456	acetyltransferase
CR091_RS05995	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CR091_RS06010	COG2252	PERMEase
CR091_RS06020	COG3279	Response regulator of the LytR AlgR family
CR091_RS06025	COG4555	ABC transporter
CR091_RS06030	COG1668	transmembrane transport
CR091_RS06040	COG0789	Transcriptional regulator
CR091_RS06045	COG1846	Transcriptional regulator
CR091_RS06050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CR091_RS06050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CR091_RS06070	COG1785	Belongs to the alkaline phosphatase family
CR091_RS06075	COG3279	Response regulator of the LytR AlgR family
CR091_RS06080	COG2205	protein histidine kinase activity
CR091_RS06080	COG0784	Response regulator, receiver
CR091_RS06085	COG0861	Integral membrane protein TerC family
CR091_RS06090	COG1191	sigma factor activity
CR091_RS06120	COG3243	poly(R)-hydroxyalkanoic acid synthase
CR091_RS06125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CR091_RS06140	COG2186	Transcriptional regulator
CR091_RS06145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CR091_RS06155	COG0247	lactate metabolic process
CR091_RS06160	COG1139	Iron-sulfur cluster binding protein
CR091_RS06165	COG1556	Lactate utilization protein
CR091_RS06170	COG5002	protein histidine kinase activity
CR091_RS06175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CR091_RS06185	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CR091_RS06190	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CR091_RS06195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CR091_RS06200	COG0436	Aminotransferase
CR091_RS06205	COG1850	ribulose-bisphosphate carboxylase activity
CR091_RS06210	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CR091_RS06215	COG0235	Class ii aldolase
CR091_RS06220	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CR091_RS06230	COG1129	ABC transporter
CR091_RS06235	COG1172	Belongs to the binding-protein-dependent transport system permease family
CR091_RS06260	COG1846	Transcriptional regulator
CR091_RS06270	COG4191	Histidine kinase
CR091_RS06280	COG0542	response to heat
CR091_RS06285	COG1757	Na H antiporter
CR091_RS06295	COG0300	oxidoreductase activity
CR091_RS06300	COG0697	spore germination
CR091_RS06320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CR091_RS06325	COG0720	synthase
CR091_RS06335	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CR091_RS06340	COG0702	epimerase
CR091_RS06350	COG4873	Protein conserved in bacteria
CR091_RS06370	COG3773	Cell wall hydrolase
CR091_RS06410	COG1410	methionine synthase
CR091_RS06410	COG0646	methionine synthase
CR091_RS06415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CR091_RS06415	COG0646	methionine synthase
CR091_RS06420	COG3949	Membrane
CR091_RS06430	COG0307	riboflavin synthase, alpha
CR091_RS06440	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CR091_RS06450	COG3711	transcriptional antiterminator
CR091_RS06455	COG2190	(PTS) system
CR091_RS06455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CR091_RS06455	COG1263	PTS System
CR091_RS06470	COG1346	cytolysis
CR091_RS06480	COG0583	DNA-binding transcription factor activity
CR091_RS06490	COG0456	acetyltransferase
CR091_RS06495	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS06500	COG0778	Nitroreductase
CR091_RS06505	COG0436	Aminotransferase
CR091_RS06525	COG0784	Response regulator, receiver
CR091_RS06525	COG0835	chemotaxis
CR091_RS06535	COG1376	ErfK ybiS ycfS ynhG family protein
CR091_RS06540	COG0248	Ppx GppA phosphatase
CR091_RS06555	COG1408	metallophosphoesterase
CR091_RS06560	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS06565	COG2200	EAL domain
CR091_RS06580	COG4703	Protein of unknown function (DUF1797)
CR091_RS06585	COG0517	IMP dehydrogenase activity
CR091_RS06590	COG0583	DNA-binding transcription factor activity
CR091_RS06595	COG2171	N-acyltransferase activity
CR091_RS06600	COG1473	amidohydrolase
CR091_RS06610	COG0668	transmembrane transport
CR091_RS06615	COG0450	alkyl hydroperoxide reductase
CR091_RS06620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CR091_RS06625	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CR091_RS06630	COG1132	(ABC) transporter
CR091_RS06635	COG1132	(ABC) transporter
CR091_RS06640	COG0569	domain protein
CR091_RS06645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CR091_RS06650	COG5503	Protein of unknown function (DUF1447)
CR091_RS06655	COG0561	phosphatase activity
CR091_RS06680	COG0022	dehydrogenase e1 component
CR091_RS06685	COG0508	dehydrogenase complex catalyzes the overall conversion of
CR091_RS06700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CR091_RS06710	COG1982	Orn Lys Arg decarboxylase major
CR091_RS06715	COG4476	Belongs to the UPF0223 family
CR091_RS06725	COG4493	Belongs to the UPF0637 family
CR091_RS06735	COG0483	inositol monophosphate 1-phosphatase activity
CR091_RS06745	COG1217	gtp-binding protein TYPA
CR091_RS06760	COG4896	Protein conserved in bacteria
CR091_RS06775	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CR091_RS06780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CR091_RS06785	COG4838	Belongs to the UPF0358 family
CR091_RS06790	COG0772	Belongs to the SEDS family
CR091_RS06795	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CR091_RS06800	COG1612	heme a metabolic process
CR091_RS06805	COG0109	protoheme IX farnesyltransferase activity
CR091_RS06830	COG3336	cytochrome c oxidase
CR091_RS06840	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CR091_RS06845	COG2340	Cysteine-rich secretory protein family
CR091_RS06855	COG2738	Putative neutral zinc metallopeptidase
CR091_RS06860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR091_RS06865	COG1694	Mazg nucleotide pyrophosphohydrolase
CR091_RS06870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CR091_RS06875	COG1803	Methylglyoxal synthase
CR091_RS06880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CR091_RS06885	COG0438	transferase activity, transferring glycosyl groups
CR091_RS06890	COG0617	tRNA 3'-terminal CCA addition
CR091_RS06895	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CR091_RS06895	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CR091_RS06905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CR091_RS06910	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CR091_RS06915	COG1199	ATP-dependent helicase activity
CR091_RS06915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CR091_RS06935	COG0436	Aminotransferase
CR091_RS06940	COG0017	Asparaginyl-tRNA synthetase
CR091_RS06945	COG3935	DnaD domain protein
CR091_RS06950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CR091_RS06960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CR091_RS06960	COG4499	WXG100 protein secretion system (Wss), protein YukC
CR091_RS06965	COG3331	DNA recombination
CR091_RS07000	COG5337	Spore coat protein CotH
CR091_RS07015	COG0626	cystathionine gamma-synthase activity
CR091_RS07020	COG0626	cystathionine gamma-synthase activity
CR091_RS07035	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CR091_RS07060	COG3706	GGDEF domain
CR091_RS07070	COG1205	dead DEAH box helicase
CR091_RS07070	COG1111	helicase
CR091_RS07075	COG3359	exonuclease
CR091_RS07085	COG4474	Belongs to the UPF0398 family
CR091_RS07090	COG3599	regulation of cell shape
CR091_RS07120	COG2197	response regulator
CR091_RS07125	COG0366	Alpha amylase catalytic
CR091_RS07130	COG0116	Belongs to the methyltransferase superfamily
CR091_RS07145	COG1175	transmembrane transport
CR091_RS07155	COG3842	ATPase activity
CR091_RS07165	COG1199	ATP-dependent helicase activity
CR091_RS07170	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CR091_RS07175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CR091_RS07180	COG2233	PERMEase
CR091_RS07185	COG0583	DNA-binding transcription factor activity
CR091_RS07190	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS07205	COG3424	synthase
CR091_RS07210	COG1755	Isoprenylcysteine carboxyl methyltransferase
CR091_RS07215	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CR091_RS07220	COG3541	Predicted nucleotidyltransferase
CR091_RS07245	COG0328	RNA-DNA hybrid ribonuclease activity
CR091_RS07250	COG0328	RNA-DNA hybrid ribonuclease activity
CR091_RS07275	COG2814	Major facilitator Superfamily
CR091_RS07285	COG2233	PERMEase
CR091_RS07290	COG2362	D-Aminopeptidase
CR091_RS07295	COG0601	transmembrane transport
CR091_RS07300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CR091_RS07305	COG0444	Belongs to the ABC transporter superfamily
CR091_RS07310	COG4166	transmembrane transport
CR091_RS07315	COG1619	proteins homologs of microcin C7 resistance protein MccF
CR091_RS07320	COG0791	NLP P60 protein
CR091_RS07325	COG4608	Belongs to the ABC transporter superfamily
CR091_RS07345	COG3300	MHYT domain
CR091_RS07345	COG5001	Diguanylate cyclase
CR091_RS07350	COG3689	TIGRFAM TIGR03943 family protein
CR091_RS07355	COG0701	Predicted permease
CR091_RS07360	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CR091_RS07365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR091_RS07370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR091_RS07375	COG1120	ATPase activity
CR091_RS07405	COG2197	response regulator
CR091_RS07410	COG4585	Histidine kinase
CR091_RS07415	COG3239	Fatty acid desaturase
CR091_RS07420	COG2205	protein histidine kinase activity
CR091_RS07430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CR091_RS07445	COG0791	NLP P60 protein
CR091_RS07445	COG1388	LysM domain
CR091_RS07450	COG1819	glycosyl
CR091_RS07455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CR091_RS07465	COG2814	Major facilitator Superfamily
CR091_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS07485	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CR091_RS07490	COG1404	Belongs to the peptidase S8 family
CR091_RS07500	COG1846	Transcriptional regulator
CR091_RS07505	COG1566	PFAM secretion protein HlyD family protein
CR091_RS07510	COG2814	Major facilitator Superfamily
CR091_RS07515	COG1846	Transcriptional regulator
CR091_RS07535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR091_RS07540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR091_RS07545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CR091_RS07550	COG1120	ATPase activity
CR091_RS07555	COG0492	ferredoxin-NADP+ reductase activity
CR091_RS07565	COG2814	Major facilitator Superfamily
CR091_RS07585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CR091_RS07590	COG1733	regulation of RNA biosynthetic process
CR091_RS07595	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CR091_RS07605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CR091_RS07615	COG3448	diguanylate cyclase activity
CR091_RS07615	COG4175	Glycine betaine
CR091_RS07630	COG0469	pyruvate kinase activity
CR091_RS07635	COG0784	Response regulator, receiver
CR091_RS07635	COG2205	protein histidine kinase activity
CR091_RS07640	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CR091_RS07645	COG2208	phosphoserine phosphatase activity
CR091_RS07655	COG0531	amino acid
CR091_RS07665	COG1011	Hydrolase
CR091_RS07670	COG0405	Gamma-glutamyltransferase
CR091_RS07675	COG1621	beta-fructofuranosidase activity
CR091_RS07680	COG1621	beta-fructofuranosidase activity
CR091_RS07685	COG2193	ferroxidase activity
CR091_RS07690	COG0477	Major facilitator Superfamily
CR091_RS07695	COG0156	8-amino-7-oxononanoate synthase activity
CR091_RS07700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CR091_RS07710	COG2814	Major facilitator Superfamily
CR091_RS07725	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS07735	COG1280	lysine exporter protein (LysE YggA)
CR091_RS07740	COG1113	amino acid transport
CR091_RS07750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CR091_RS07770	COG1113	amino acid transport
CR091_RS07785	COG1609	Transcriptional regulator
CR091_RS07800	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CR091_RS07805	COG1621	beta-fructofuranosidase activity
CR091_RS07810	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CR091_RS07810	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CR091_RS07815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CR091_RS07820	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CR091_RS07825	COG3715	PTS system
CR091_RS07830	COG3716	PTS system mannose fructose sorbose family IID component
CR091_RS07835	COG1621	beta-fructofuranosidase activity
CR091_RS07840	COG0024	Methionine aminopeptidase
CR091_RS07850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CR091_RS07860	COG0656	L-ascorbic acid biosynthetic process
CR091_RS07865	COG2986	histidine ammonia-lyase
CR091_RS07875	COG1228	amidohydrolase
CR091_RS07880	COG0010	Belongs to the arginase family
CR091_RS07885	COG1846	Transcriptional regulator
CR091_RS07900	COG1288	antiporter activity
CR091_RS07905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CR091_RS07935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS07950	COG2364	Membrane
CR091_RS07955	COG1846	Transcriptional regulator
CR091_RS07960	COG0456	acetyltransferase
CR091_RS07965	COG0640	Transcriptional regulator
CR091_RS08030	COG3848	Pyruvate phosphate dikinase
CR091_RS08030	COG0574	Belongs to the PEP-utilizing enzyme family
CR091_RS08035	COG1309	transcriptional regulator
CR091_RS08040	COG2814	Major facilitator Superfamily
CR091_RS08045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CR091_RS08050	COG3958	Transketolase
CR091_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS08060	COG2186	Transcriptional regulator
CR091_RS08075	COG0698	ribose 5-phosphate isomerase
CR091_RS08080	COG0494	nUDIX hydrolase
CR091_RS08095	COG0791	NLP P60 protein
CR091_RS08095	COG1388	LysM domain
CR091_RS08100	COG0772	Belongs to the SEDS family
CR091_RS08120	COG2318	DinB family
CR091_RS08155	COG0583	DNA-binding transcription factor activity
CR091_RS08160	COG0596	Alpha beta hydrolase
CR091_RS08160	COG2945	thiolester hydrolase activity
CR091_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS08205	COG0586	Pfam SNARE associated Golgi protein
CR091_RS08225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CR091_RS08235	COG0697	spore germination
CR091_RS08270	COG0387	Pfam Sodium calcium exchanger
CR091_RS08275	COG0318	PFAM AMP-dependent synthetase and ligase
CR091_RS08300	COG1309	transcriptional regulator
CR091_RS08305	COG0861	Integral membrane protein TerC family
CR091_RS08310	COG2188	Transcriptional regulator
CR091_RS08325	COG2723	6-phospho-beta-galactosidase activity
CR091_RS08335	COG1940	carbohydrate kinase activity
CR091_RS08350	COG1522	sequence-specific DNA binding
CR091_RS08355	COG3813	Protein conserved in bacteria
CR091_RS08390	COG2076	Multidrug Resistance protein
CR091_RS08425	COG1278	Cold shock
CR091_RS08435	COG0028	Belongs to the TPP enzyme family
CR091_RS08480	COG2172	sigma factor antagonist activity
CR091_RS08485	COG1388	LysM domain
CR091_RS08485	COG3858	chitin binding
CR091_RS08490	COG1376	ErfK ybiS ycfS ynhG family protein
CR091_RS08495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CR091_RS08530	COG2226	methyltransferase
CR091_RS08545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS08560	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CR091_RS08565	COG0640	Transcriptional regulator
CR091_RS08575	COG0640	Transcriptional regulator
CR091_RS08580	COG0346	lactoylglutathione lyase activity
CR091_RS08585	COG5553	Cysteine dioxygenase type I
CR091_RS08590	COG0697	spore germination
CR091_RS08595	COG1733	regulation of RNA biosynthetic process
CR091_RS08600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CR091_RS08610	COG2207	Transcriptional regulator
CR091_RS08620	COG2376	Dihydroxyacetone kinase
CR091_RS08650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CR091_RS08685	COG2318	DinB family
CR091_RS08725	COG1266	CAAX protease self-immunity
CR091_RS08735	COG2814	Major facilitator Superfamily
CR091_RS08740	COG0789	Transcriptional regulator
CR091_RS08745	COG0667	Aldo Keto reductase
CR091_RS08925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CR091_RS08935	COG4282	regulation of fungal-type cell wall biogenesis
CR091_RS08965	COG0574	Belongs to the PEP-utilizing enzyme family
CR091_RS08965	COG3848	Pyruvate phosphate dikinase
CR091_RS08970	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CR091_RS08980	COG0601	transmembrane transport
CR091_RS08985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CR091_RS08990	COG0444	Belongs to the ABC transporter superfamily
CR091_RS08995	COG4608	Belongs to the ABC transporter superfamily
CR091_RS09000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CR091_RS09015	COG0477	Major facilitator Superfamily
CR091_RS09030	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS09065	COG0517	IMP dehydrogenase activity
CR091_RS09080	COG1309	transcriptional regulator
CR091_RS09095	COG1070	Carbohydrate kinase
CR091_RS09100	COG0477	Major facilitator Superfamily
CR091_RS09100	COG2814	Major facilitator Superfamily
CR091_RS09110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CR091_RS09115	COG1845	cytochrome c oxidase, subunit III
CR091_RS09125	COG0589	response to stress
CR091_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS09135	COG1612	heme a metabolic process
CR091_RS09140	COG2072	flavoprotein involved in K transport
CR091_RS09150	COG2252	PERMEase
CR091_RS09160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CR091_RS09165	COG0022	dehydrogenase e1 component
CR091_RS09170	COG0508	dehydrogenase complex catalyzes the overall conversion of
CR091_RS09175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CR091_RS09180	COG3284	Transcriptional regulator
CR091_RS09190	COG1846	Transcriptional regulator
CR091_RS09225	COG0628	permease
CR091_RS09230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CR091_RS09235	COG1904	glucuronate isomerase
CR091_RS09240	COG2211	Major facilitator Superfamily
CR091_RS09245	COG1609	Transcriptional regulator
CR091_RS09250	COG0246	Mannitol dehydrogenase
CR091_RS09255	COG2721	sulfolactate sulfo-lyase activity
CR091_RS09270	COG2211	Major facilitator Superfamily
CR091_RS09290	COG0589	response to stress
CR091_RS09295	COG5002	protein histidine kinase activity
CR091_RS09305	COG1937	Protein conserved in bacteria
CR091_RS09310	COG2608	mercury ion transmembrane transporter activity
CR091_RS09315	COG2217	Heavy metal translocating P-type atpase
CR091_RS09325	COG1388	LysM domain
CR091_RS09330	COG2271	Major facilitator Superfamily
CR091_RS09370	COG0640	Transcriptional regulator
CR091_RS09375	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CR091_RS09380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CR091_RS09385	COG2050	protein possibly involved in aromatic compounds catabolism
CR091_RS09390	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CR091_RS09395	COG2323	membrane
CR091_RS09415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CR091_RS09420	COG0473	3-isopropylmalate dehydrogenase activity
CR091_RS09425	COG2814	Major facilitator Superfamily
CR091_RS09430	COG1733	regulation of RNA biosynthetic process
CR091_RS09435	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CR091_RS09435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CR091_RS09440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CR091_RS09440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CR091_RS09455	COG2226	methyltransferase
CR091_RS09465	COG5566	PFAM Mor transcription activator
CR091_RS09480	COG0561	phosphatase activity
CR091_RS09485	COG1876	peptidase activity
CR091_RS09530	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CR091_RS09545	COG0386	Belongs to the glutathione peroxidase family
CR091_RS09550	COG1418	mRNA catabolic process
CR091_RS09555	COG0488	(ABC) transporter
CR091_RS09560	COG1413	lyase activity
CR091_RS09565	COG0726	polysaccharide deacetylase
CR091_RS09575	COG2136	Putative SAM-dependent methyltransferase
CR091_RS09575	COG2521	methyltransferase
CR091_RS09585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CR091_RS09590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CR091_RS09600	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CR091_RS09610	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CR091_RS09615	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CR091_RS09620	COG0406	alpha-ribazole phosphatase activity
CR091_RS09630	COG2096	Adenosyltransferase
CR091_RS09635	COG2962	Rard protein
CR091_RS09650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CR091_RS09655	COG0322	excinuclease ABC activity
CR091_RS09665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CR091_RS09670	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CR091_RS09675	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CR091_RS09685	COG3011	Protein conserved in bacteria
CR091_RS09690	COG1595	DNA-templated transcription, initiation
CR091_RS09710	COG2002	toxin-antitoxin pair type II binding
CR091_RS09715	COG0534	Mate efflux family protein
CR091_RS09745	COG1368	sulfuric ester hydrolase activity
CR091_RS09755	COG3853	Toxic anion resistance protein (TelA)
CR091_RS09780	COG2234	aminopeptidase activity
CR091_RS09785	COG5002	protein histidine kinase activity
CR091_RS09795	COG1823	symporter activity
CR091_RS09800	COG1523	belongs to the glycosyl hydrolase 13 family
CR091_RS09805	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS09810	COG2124	cytochrome p450
CR091_RS09815	COG2112	serine threonine protein kinase
CR091_RS09825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CR091_RS09830	COG1360	Flagellar Motor Protein
CR091_RS09845	COG3361	conserved protein (COG2071)
CR091_RS09850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CR091_RS09855	COG1757	Na H antiporter
CR091_RS09865	COG0833	amino acid
CR091_RS09870	COG3594	Acyltransferase
CR091_RS09875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CR091_RS09880	COG0745	RESPONSE REGULATOR receiver
CR091_RS09885	COG5002	protein histidine kinase activity
CR091_RS09890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CR091_RS09895	COG3104	oligopeptide transport
CR091_RS09905	COG0281	malic enzyme
CR091_RS09910	COG3493	citrate carrier protein
CR091_RS09915	COG0561	phosphatase activity
CR091_RS09920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR091_RS09930	COG0456	acetyltransferase
CR091_RS09935	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CR091_RS09940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR091_RS09945	COG0765	amino acid transport
CR091_RS09950	COG0765	amino acid transport
CR091_RS09955	COG1126	abc transporter atp-binding protein
CR091_RS09960	COG0196	riboflavin kinase activity
CR091_RS09965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR091_RS09975	COG0860	N-Acetylmuramoyl-L-alanine amidase
CR091_RS10015	COG1611	Belongs to the LOG family
CR091_RS10020	COG0281	malic enzyme
CR091_RS10025	COG3402	PFAM membrane-flanked domain
CR091_RS10030	COG3428	Bacterial PH domain
CR091_RS10045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CR091_RS10050	COG0109	protoheme IX farnesyltransferase activity
CR091_RS10055	COG4195	phage-related replication protein
CR091_RS10065	COG0789	Transcriptional regulator
CR091_RS10100	COG0583	DNA-binding transcription factor activity
CR091_RS10105	COG0067	glutamate synthase
CR091_RS10105	COG0069	glutamate synthase activity
CR091_RS10105	COG0070	glutamate synthase
CR091_RS10110	COG0493	'glutamate synthase
CR091_RS10130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CR091_RS10145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CR091_RS10160	COG1846	Transcriptional regulator
CR091_RS10165	COG1380	Effector of murein hydrolase LrgA
CR091_RS10170	COG1346	cytolysis
CR091_RS10175	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS10190	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CR091_RS10195	COG0463	Glycosyl transferase, family 2
CR091_RS10200	COG2246	polysaccharide biosynthetic process
CR091_RS10205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CR091_RS10210	COG0745	RESPONSE REGULATOR receiver
CR091_RS10220	COG5583	Uncharacterized small protein (DUF2292)
CR091_RS10230	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CR091_RS10240	COG4208	sulfate ABC transporter
CR091_RS10255	COG0745	RESPONSE REGULATOR receiver
CR091_RS10280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR091_RS10290	COG1349	DNA-binding transcription factor activity
CR091_RS10295	COG1105	Belongs to the carbohydrate kinase PfkB family
CR091_RS10300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CR091_RS10300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CR091_RS10300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CR091_RS10305	COG0527	aspartate kinase activity
CR091_RS10315	COG2032	superoxide dismutase activity
CR091_RS10320	COG1233	COG1233 Phytoene dehydrogenase and related
CR091_RS10330	COG0300	oxidoreductase activity
CR091_RS10335	COG0640	Transcriptional regulator
CR091_RS10340	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS10345	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CR091_RS10360	COG0733	neurotransmitter:sodium symporter activity
CR091_RS10365	COG3773	Cell wall hydrolase
CR091_RS10385	COG0673	inositol 2-dehydrogenase activity
CR091_RS10390	COG1082	Xylose isomerase domain protein TIM barrel
CR091_RS10395	COG2094	Belongs to the DNA glycosylase MPG family
CR091_RS10405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CR091_RS10415	COG0454	-acetyltransferase
CR091_RS10425	COG2814	Major facilitator Superfamily
CR091_RS10440	COG3871	stress protein (general stress protein 26)
CR091_RS10465	COG1595	DNA-templated transcription, initiation
CR091_RS10470	COG4873	Protein conserved in bacteria
CR091_RS10475	COG0714	Associated with various cellular activities
CR091_RS10480	COG4548	von Willebrand factor, type A
CR091_RS10485	COG0697	spore germination
CR091_RS10495	COG2207	Transcriptional regulator
CR091_RS10500	COG1994	Peptidase M50
CR091_RS10510	COG1119	ATPase activity
CR091_RS10525	COG1657	PFAM Prenyltransferase squalene oxidase
CR091_RS10535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CR091_RS10535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CR091_RS10555	COG1378	Sugar-specific transcriptional regulator TrmB
CR091_RS10565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CR091_RS10570	COG0300	oxidoreductase activity
CR091_RS10590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CR091_RS10595	COG1279	arginine transmembrane transporter activity
CR091_RS10625	COG3541	Predicted nucleotidyltransferase
CR091_RS10665	COG0489	protein tyrosine kinase activity
CR091_RS10670	COG1086	Polysaccharide biosynthesis protein
CR091_RS10675	COG0438	transferase activity, transferring glycosyl groups
CR091_RS10680	COG0438	transferase activity, transferring glycosyl groups
CR091_RS10685	COG1215	transferase activity, transferring glycosyl groups
CR091_RS10695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CR091_RS10700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CR091_RS10705	COG0110	maltose O-acetyltransferase activity
CR091_RS10710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CR091_RS10715	COG1396	sequence-specific DNA binding
CR091_RS10730	COG1216	Glycosyl transferase, family 2
CR091_RS10730	COG1442	glycosyl transferase family 8
CR091_RS10735	COG0438	transferase activity, transferring glycosyl groups
CR091_RS10750	COG1442	glycosyl transferase family 8
CR091_RS10750	COG1216	Glycosyl transferase, family 2
CR091_RS10755	COG0438	transferase activity, transferring glycosyl groups
CR091_RS10760	COG1216	Glycosyl transferase, family 2
CR091_RS10760	COG1442	glycosyl transferase family 8
CR091_RS10800	COG1132	(ABC) transporter
CR091_RS10835	COG1408	metallophosphoesterase
CR091_RS10850	COG0494	nUDIX hydrolase
CR091_RS10855	COG1335	isochorismatase
CR091_RS10860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CR091_RS10865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CR091_RS10870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CR091_RS10875	COG1098	S1 RNA binding domain
CR091_RS10880	COG1404	Belongs to the peptidase S8 family
CR091_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS10890	COG1254	Belongs to the acylphosphatase family
CR091_RS10895	COG2223	nitrite transmembrane transporter activity
CR091_RS10900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR091_RS10910	COG2207	Transcriptional regulator
CR091_RS10910	COG0662	Cupin 2, conserved barrel domain protein
CR091_RS10915	COG0697	spore germination
CR091_RS10920	COG0488	(ABC) transporter
CR091_RS10930	COG0697	spore germination
CR091_RS10935	COG0531	amino acid
CR091_RS10950	COG1131	(ABC) transporter
CR091_RS10955	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CR091_RS10960	COG1757	Na H antiporter
CR091_RS10965	COG1609	Transcriptional regulator
CR091_RS10975	COG1533	DNA photolyase activity
CR091_RS10995	COG0551	DNA topoisomerase type I activity
CR091_RS10995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CR091_RS11005	COG0446	pyridine nucleotide-disulphide oxidoreductase
CR091_RS11040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CR091_RS11060	COG1757	Na H antiporter
CR091_RS11065	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CR091_RS11075	COG0697	spore germination
CR091_RS11085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS11095	COG5002	protein histidine kinase activity
CR091_RS11100	COG2204	response regulator
CR091_RS11115	COG4948	Mandelate Racemase Muconate Lactonizing
CR091_RS11120	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS11125	COG1027	Aspartate ammonia-lyase
CR091_RS11130	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS11140	COG1454	alcohol dehydrogenase
CR091_RS11145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CR091_RS11150	COG2720	vancomycin resistance protein
CR091_RS11190	COG0514	ATP-dependent DNA helicase (RecQ)
CR091_RS11205	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS11225	COG1575	Belongs to the MenA family. Type 1 subfamily
CR091_RS11245	COG2814	Major facilitator Superfamily
CR091_RS11250	COG0583	DNA-binding transcription factor activity
CR091_RS11255	COG1725	Transcriptional regulator
CR091_RS11260	COG1131	(ABC) transporter
CR091_RS11270	COG1595	DNA-templated transcription, initiation
CR091_RS11285	COG1764	response to oxidative stress
CR091_RS11290	COG1846	Transcriptional regulator
CR091_RS11305	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CR091_RS11315	COG1388	LysM domain
CR091_RS11315	COG3584	3D domain protein
CR091_RS11335	COG5002	protein histidine kinase activity
CR091_RS11340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CR091_RS11345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CR091_RS11350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CR091_RS11365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CR091_RS11380	COG2409	Drug exporters of the RND superfamily
CR091_RS11385	COG1834	amidinotransferase
CR091_RS11395	COG1295	ribonuclease BN
CR091_RS11445	COG0346	lactoylglutathione lyase activity
CR091_RS11455	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS11465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CR091_RS11475	COG2176	DNA-directed DNA polymerase activity
CR091_RS11490	COG0114	fumarate hydratase activity
CR091_RS11500	COG3757	hydrolase, family 25
CR091_RS11500	COG3409	Peptidoglycan-binding domain 1 protein
CR091_RS11510	COG5002	protein histidine kinase activity
CR091_RS11550	COG0778	Nitroreductase
CR091_RS11560	COG0300	oxidoreductase activity
CR091_RS11570	COG2610	gluconate transmembrane transporter activity
CR091_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS11580	COG2195	Cleaves the N-terminal amino acid of tripeptides
CR091_RS11595	COG4122	O-methyltransferase activity
CR091_RS11600	COG0583	DNA-binding transcription factor activity
CR091_RS11615	COG1301	dicarboxylic acid transport
CR091_RS11620	COG0019	diaminopimelate decarboxylase activity
CR091_RS11630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CR091_RS11640	COG4191	Histidine kinase
CR091_RS11655	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS11660	COG0318	PFAM AMP-dependent synthetase and ligase
CR091_RS11670	COG1250	3-hydroxyacyl-CoA dehydrogenase
CR091_RS11675	COG1024	Enoyl-CoA hydratase
CR091_RS11690	COG2045	Belongs to the ComB family
CR091_RS11695	COG1960	acyl-CoA dehydrogenase activity
CR091_RS11700	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS11705	COG1024	Enoyl-CoA hydratase
CR091_RS11720	COG1141	Ferredoxin
CR091_RS11730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CR091_RS11735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CR091_RS11740	COG0183	Belongs to the thiolase family
CR091_RS11745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CR091_RS11750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CR091_RS11770	COG1509	lysine 2,3-aminomutase activity
CR091_RS11780	COG0833	amino acid
CR091_RS11785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CR091_RS11800	COG1979	alcohol dehydrogenase
CR091_RS11805	COG0738	Major facilitator superfamily
CR091_RS11810	COG1181	Belongs to the D-alanine--D-alanine ligase family
CR091_RS11830	COG3977	Valine--pyruvate aminotransferase
CR091_RS11840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CR091_RS11845	COG3773	Cell wall hydrolase
CR091_RS11855	COG3119	arylsulfatase activity
CR091_RS11860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CR091_RS11870	COG0531	amino acid
CR091_RS11875	COG2814	Major facilitator Superfamily
CR091_RS11880	COG1846	Transcriptional regulator
CR091_RS11885	COG2409	Drug exporters of the RND superfamily
CR091_RS11885	COG1033	growth of symbiont in host cell
CR091_RS11890	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS11890	COG2202	Pas domain
CR091_RS11895	COG3832	glyoxalase III activity
CR091_RS11900	COG0640	Transcriptional regulator
CR091_RS11915	COG2267	carboxylic ester hydrolase activity
CR091_RS11925	COG3386	PFAM SMP-30 Gluconolaconase
CR091_RS11935	COG2368	4-hydroxyphenylacetate
CR091_RS11940	COG3739	integral membrane protein
CR091_RS11950	COG0326	Molecular chaperone. Has ATPase activity
CR091_RS11955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CR091_RS11975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CR091_RS11990	COG0697	spore germination
CR091_RS11995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CR091_RS12015	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CR091_RS12020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CR091_RS12070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CR091_RS12085	COG0494	nUDIX hydrolase
CR091_RS12090	COG0702	epimerase
CR091_RS12095	COG0318	PFAM AMP-dependent synthetase and ligase
CR091_RS12100	COG1846	Transcriptional regulator
CR091_RS12105	COG2720	vancomycin resistance protein
CR091_RS12110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CR091_RS12150	COG0076	glutamate decarboxylase activity
CR091_RS12175	COG2116	formate transmembrane transporter activity
CR091_RS12180	COG5609	conserved protein (DUF2294)
CR091_RS12195	COG2271	Major facilitator Superfamily
CR091_RS12200	COG0277	FAD linked oxidase domain protein
CR091_RS12205	COG0840	transmembrane signaling receptor activity
CR091_RS12215	COG0622	Phosphoesterase
CR091_RS12225	COG1408	metallophosphoesterase
CR091_RS12230	COG3663	DNA glycosylase
CR091_RS12235	COG0791	NLP P60 protein
CR091_RS12235	COG3883	PFAM NLP P60 protein
CR091_RS12240	COG1587	Uroporphyrinogen-III synthase
CR091_RS12245	COG1414	Transcriptional regulator
CR091_RS12250	COG0439	Biotin carboxylase
CR091_RS12255	COG0511	ligase activity, forming carbon-carbon bonds
CR091_RS12260	COG1984	allophanate hydrolase subunit 2
CR091_RS12265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CR091_RS12270	COG4336	lyase activity
CR091_RS12275	COG1914	H( )-stimulated, divalent metal cation uptake system
CR091_RS12280	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CR091_RS12295	COG0693	protein deglycase activity
CR091_RS12305	COG0586	Pfam SNARE associated Golgi protein
CR091_RS12315	COG0745	RESPONSE REGULATOR receiver
CR091_RS12325	COG0604	alcohol dehydrogenase
CR091_RS12335	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CR091_RS12365	COG0456	acetyltransferase
CR091_RS12365	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CR091_RS12405	COG0318	PFAM AMP-dependent synthetase and ligase
CR091_RS12410	COG1268	BioY protein
CR091_RS12415	COG0183	Belongs to the thiolase family
CR091_RS12435	COG0431	NADPH-dependent FMN reductase
CR091_RS12440	COG2197	response regulator
CR091_RS12445	COG2203	Gaf domain
CR091_RS12445	COG4585	Histidine kinase
CR091_RS12465	COG0697	spore germination
CR091_RS12475	COG2153	protein acetylation
CR091_RS12480	COG0129	dihydroxy-acid dehydratase activity
CR091_RS12485	COG2267	carboxylic ester hydrolase activity
CR091_RS12490	COG1227	inorganic diphosphatase activity
CR091_RS12510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CR091_RS12520	COG0204	Acyl-transferase
CR091_RS12525	COG2233	PERMEase
CR091_RS12530	COG3195	allantoin biosynthetic process
CR091_RS12530	COG3648	Uricase
CR091_RS12540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS12555	COG1914	H( )-stimulated, divalent metal cation uptake system
CR091_RS12570	COG1011	Hydrolase
CR091_RS12575	COG1846	Transcriptional regulator
CR091_RS12585	COG4974	Belongs to the 'phage' integrase family
CR091_RS12600	COG0531	amino acid
CR091_RS12605	COG4302	ethanolamine ammonia-lyase activity
CR091_RS12610	COG4303	Ethanolamine ammonia lyase large subunit
CR091_RS12615	COG4819	ethanolamine utilization protein
CR091_RS12625	COG0833	amino acid
CR091_RS12635	COG1247	-acetyltransferase
CR091_RS12640	COG1335	isochorismatase
CR091_RS12650	COG3403	YqcI/YcgG family
CR091_RS12655	COG1280	lysine exporter protein (LysE YggA)
CR091_RS12660	COG2267	carboxylic ester hydrolase activity
CR091_RS12670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CR091_RS12675	COG0187	DNA topoisomerase II activity
CR091_RS12680	COG1832	CoA-binding protein
CR091_RS12685	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CR091_RS12690	COG4841	protein insertion into membrane
CR091_RS12695	COG0824	Thioesterase
CR091_RS12725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CR091_RS12730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CR091_RS12750	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CR091_RS12785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CR091_RS12790	COG2068	MobA-Related Protein
CR091_RS12795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CR091_RS12855	COG1183	phosphatidylcholine synthase activity
CR091_RS12870	COG2814	Major facilitator Superfamily
CR091_RS12880	COG1683	Conserved Protein
CR091_RS12885	COG1302	Protein conserved in bacteria
CR091_RS12900	COG1295	ribonuclease BN
CR091_RS12910	COG1115	amino acid carrier protein
CR091_RS12915	COG2814	Major facilitator Superfamily
CR091_RS12925	COG2814	Major facilitator Superfamily
CR091_RS12930	COG0789	Transcriptional regulator
CR091_RS12940	COG0288	reversible hydration of carbon dioxide
CR091_RS12945	COG0659	secondary active sulfate transmembrane transporter activity
CR091_RS12950	COG0745	RESPONSE REGULATOR receiver
CR091_RS12965	COG4282	regulation of fungal-type cell wall biogenesis
CR091_RS12970	COG0531	amino acid
CR091_RS12980	COG0860	N-Acetylmuramoyl-L-alanine amidase
CR091_RS12985	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CR091_RS13055	COG1363	Peptidase, m42
CR091_RS13065	COG1114	Component of the transport system for branched-chain amino acids
CR091_RS13085	COG0004	ammonium transporteR
CR091_RS13100	COG1252	NADH dehydrogenase
CR091_RS13105	COG0679	Auxin Efflux Carrier
CR091_RS13110	COG0281	malic enzyme
CR091_RS13115	COG1473	amidohydrolase
CR091_RS13120	COG2271	Major facilitator Superfamily
CR091_RS13140	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CR091_RS13145	COG0163	prenyltransferase activity
CR091_RS13150	COG0583	DNA-binding transcription factor activity
CR091_RS13155	COG0679	Auxin Efflux Carrier
CR091_RS13175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR091_RS13180	COG0247	lactate metabolic process
CR091_RS13185	COG0277	FAD linked oxidase domain protein
CR091_RS13190	COG3835	regulator
CR091_RS13195	COG0693	protein deglycase activity
CR091_RS13205	COG2610	gluconate transmembrane transporter activity
CR091_RS13225	COG1131	(ABC) transporter
CR091_RS13235	COG2197	response regulator
CR091_RS13270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR091_RS13280	COG0586	Pfam SNARE associated Golgi protein
CR091_RS13285	COG1515	deoxyribonuclease V activity
CR091_RS13290	COG0584	glycerophosphoryl diester phosphodiesterase
CR091_RS13430	COG0534	Mate efflux family protein
CR091_RS13435	COG1566	PFAM secretion protein HlyD family protein
CR091_RS13445	COG1846	Transcriptional regulator
CR091_RS13450	COG0708	Exodeoxyribonuclease III
CR091_RS13460	COG0673	inositol 2-dehydrogenase activity
CR091_RS13465	COG1349	DNA-binding transcription factor activity
CR091_RS13470	COG3853	Toxic anion resistance protein (TelA)
CR091_RS13480	COG2310	stress, protein
CR091_RS13485	COG2310	stress, protein
CR091_RS13490	COG2310	stress, protein
CR091_RS13495	COG0737	Belongs to the 5'-nucleotidase family
CR091_RS13515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CR091_RS13520	COG1131	(ABC) transporter
CR091_RS13530	COG2084	Dehydrogenase
CR091_RS13535	COG1278	Cold shock
CR091_RS13540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CR091_RS13550	COG0028	Belongs to the TPP enzyme family
CR091_RS13555	COG1278	Cold shock
CR091_RS13585	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS13595	COG0427	acetyl-CoA hydrolase
CR091_RS13600	COG3279	Response regulator of the LytR AlgR family
CR091_RS13605	COG2323	membrane
CR091_RS13610	COG2814	Major facilitator Superfamily
CR091_RS13615	COG1388	LysM domain
CR091_RS13615	COG3584	3D domain protein
CR091_RS13620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CR091_RS13645	COG3340	Belongs to the peptidase S51 family
CR091_RS13670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CR091_RS13700	COG2318	DinB family
CR091_RS13710	COG0579	oxidoreductase
CR091_RS13815	COG5444	nuclease activity
CR091_RS13835	COG0488	(ABC) transporter
CR091_RS13840	COG1486	melibiose metabolic process
CR091_RS13845	COG0395	ABC-type sugar transport system, permease component
CR091_RS13850	COG1175	transmembrane transport
CR091_RS13855	COG1653	transport
CR091_RS13860	COG1609	Transcriptional regulator
CR091_RS13875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CR091_RS13895	COG0596	Alpha beta hydrolase
CR091_RS13900	COG1929	Belongs to the glycerate kinase type-1 family
CR091_RS13905	COG2610	gluconate transmembrane transporter activity
CR091_RS13910	COG3835	regulator
CR091_RS13915	COG3290	protein histidine kinase activity
CR091_RS13915	COG3829	transcription factor binding
CR091_RS13925	COG1454	alcohol dehydrogenase
CR091_RS13930	COG3152	Membrane
CR091_RS13945	COG0492	ferredoxin-NADP+ reductase activity
CR091_RS13955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR091_RS13960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR091_RS13965	COG3152	Membrane
CR091_RS13970	COG3152	Membrane
CR091_RS13990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CR091_RS14000	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CR091_RS14015	COG2390	Transcriptional regulator
CR091_RS14045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CR091_RS14050	COG0501	Belongs to the peptidase M48B family
CR091_RS14055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CR091_RS14060	COG1742	UPF0060 membrane protein
CR091_RS14070	COG2182	Extracellular solute-binding protein
CR091_RS14090	COG2031	fatty acid transporter
CR091_RS14115	COG2391	methyltransferase activity
CR091_RS14130	COG1979	alcohol dehydrogenase
CR091_RS14135	COG0583	DNA-binding transcription factor activity
CR091_RS14150	COG1214	PFAM Peptidase M22, glycoprotease
CR091_RS14150	COG0456	acetyltransferase
CR091_RS14155	COG2211	Major facilitator Superfamily
CR091_RS14185	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS14190	COG1063	alcohol dehydrogenase
CR091_RS14220	COG0025	NhaP-type Na H and K H
CR091_RS14225	COG1253	flavin adenine dinucleotide binding
CR091_RS14250	COG4608	Belongs to the ABC transporter superfamily
CR091_RS14260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CR091_RS14265	COG0601	transmembrane transport
CR091_RS14270	COG0747	negative chemotaxis
CR091_RS14280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR091_RS14310	COG0579	oxidoreductase
CR091_RS14315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CR091_RS14320	COG0561	phosphatase activity
CR091_RS14335	COG0668	transmembrane transport
CR091_RS14365	COG2309	aminopeptidase activity
CR091_RS14370	COG1414	Transcriptional regulator
CR091_RS14375	COG0179	Fumarylacetoacetate (FAA) hydrolase
CR091_RS14380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CR091_RS14385	COG0277	FAD linked oxidase domain protein
CR091_RS14390	COG0247	lactate metabolic process
CR091_RS14395	COG0277	FAD linked oxidase domain protein
CR091_RS14400	COG1620	l-lactate permease
CR091_RS14420	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CR091_RS14425	COG1131	(ABC) transporter
CR091_RS14445	COG1595	DNA-templated transcription, initiation
CR091_RS14470	COG4682	membrane
CR091_RS14485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR091_RS14490	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS14495	COG0598	Magnesium transport protein CorA
CR091_RS14500	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CR091_RS14510	COG2323	membrane
CR091_RS14515	COG1876	peptidase activity
CR091_RS14525	COG5002	protein histidine kinase activity
CR091_RS14530	COG0745	RESPONSE REGULATOR receiver
CR091_RS14555	COG0508	dehydrogenase complex catalyzes the overall conversion of
CR091_RS14570	COG2814	Major facilitator Superfamily
CR091_RS14575	COG1764	response to oxidative stress
CR091_RS14585	COG2311	Membrane
CR091_RS14640	COG0347	Belongs to the P(II) protein family
CR091_RS14645	COG0004	ammonium transporteR
CR091_RS14650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CR091_RS14665	COG0596	Alpha beta hydrolase
CR091_RS14680	COG0456	acetyltransferase
CR091_RS14680	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CR091_RS14685	COG1960	acyl-CoA dehydrogenase activity
CR091_RS14725	COG4604	ABC transporter, ATP-binding protein
CR091_RS14730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR091_RS14735	COG1492	cobalamin metabolic process
CR091_RS14745	COG0531	amino acid
CR091_RS14755	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS14760	COG2404	hydrolase activity, acting on ester bonds
CR091_RS14765	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CR091_RS14775	COG1609	Transcriptional regulator
CR091_RS14785	COG2271	Major facilitator Superfamily
CR091_RS14790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CR091_RS14805	COG1233	COG1233 Phytoene dehydrogenase and related
CR091_RS14810	COG1215	transferase activity, transferring glycosyl groups
CR091_RS14865	COG0831	urea catabolic process
CR091_RS14870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CR091_RS14875	COG0791	NLP P60 protein
CR091_RS14875	COG1388	LysM domain
CR091_RS14880	COG3584	3D domain protein
CR091_RS14880	COG1388	LysM domain
CR091_RS14885	COG0778	Nitroreductase
CR091_RS14890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CR091_RS14895	COG0586	Pfam SNARE associated Golgi protein
CR091_RS14905	COG0400	carboxylic ester hydrolase activity
CR091_RS14910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CR091_RS14915	COG2244	polysaccharide biosynthetic process
CR091_RS14920	COG0697	spore germination
CR091_RS14925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CR091_RS14945	COG1132	(ABC) transporter
CR091_RS14970	COG4195	phage-related replication protein
CR091_RS14980	COG0783	Belongs to the Dps family
CR091_RS14990	COG5577	PFAM Coat F domain
CR091_RS14995	COG1253	flavin adenine dinucleotide binding
CR091_RS15010	COG0516	GMP reductase activity
CR091_RS15010	COG0517	IMP dehydrogenase activity
CR091_RS15020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CR091_RS15020	COG0723	plastoquinol--plastocyanin reductase activity
CR091_RS15035	COG0287	Prephenate dehydrogenase
CR091_RS15045	COG1605	Chorismate mutase
CR091_RS15045	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CR091_RS15055	COG2059	Chromate
CR091_RS15060	COG2059	Chromate
CR091_RS15070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CR091_RS15075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CR091_RS15080	COG2508	Transcriptional regulator
CR091_RS15085	COG0011	TIGRFAM Protein of
CR091_RS15090	COG1388	LysM domain
CR091_RS15090	COG0791	NLP P60 protein
CR091_RS15095	COG0753	catalase activity
CR091_RS15105	COG0733	neurotransmitter:sodium symporter activity
CR091_RS15145	COG0730	response to heat
CR091_RS15150	COG1902	pentaerythritol trinitrate reductase activity
CR091_RS15165	COG2205	protein histidine kinase activity
CR091_RS15175	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CR091_RS15200	COG0640	Transcriptional regulator
CR091_RS15210	COG0778	Nitroreductase
CR091_RS15225	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CR091_RS15230	COG0860	N-Acetylmuramoyl-L-alanine amidase
CR091_RS15230	COG3103	Sh3 type 3 domain protein
CR091_RS15230	COG4991	sh3 domain protein
CR091_RS15235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CR091_RS15240	COG2002	toxin-antitoxin pair type II binding
CR091_RS15245	COG2318	DinB family
CR091_RS15250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CR091_RS15260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CR091_RS15265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR091_RS15280	COG2211	Major facilitator Superfamily
CR091_RS15285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR091_RS15290	COG1597	lipid kinase activity
CR091_RS15300	COG0372	Belongs to the citrate synthase family
CR091_RS15305	COG0583	DNA-binding transcription factor activity
CR091_RS15325	COG2202	Pas domain
CR091_RS15325	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS15330	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS15360	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS15365	COG2261	transglycosylase associated protein
CR091_RS15375	COG0740	serine-type endopeptidase activity
CR091_RS15390	COG1027	Aspartate ammonia-lyase
CR091_RS15395	COG0252	asparaginase activity
CR091_RS15400	COG1396	sequence-specific DNA binding
CR091_RS15415	COG0640	Transcriptional regulator
CR091_RS15435	COG0531	amino acid
CR091_RS15440	COG1959	2 iron, 2 sulfur cluster binding
CR091_RS15465	COG0281	malic enzyme
CR091_RS15470	COG2746	aminoglycoside 3-N-acetyltransferase activity
CR091_RS15480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS15485	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS15495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CR091_RS15500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CR091_RS15510	COG0477	Major facilitator Superfamily
CR091_RS15515	COG1846	Transcriptional regulator
CR091_RS15520	COG0789	Transcriptional regulator
CR091_RS15525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS15560	COG1819	glycosyl
CR091_RS15580	COG1902	pentaerythritol trinitrate reductase activity
CR091_RS15590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CR091_RS15605	COG2814	Major facilitator Superfamily
CR091_RS15615	COG1228	amidohydrolase
CR091_RS15625	COG1316	TRANSCRIPTIONal
CR091_RS15630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS15650	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CR091_RS15660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CR091_RS15715	COG0860	N-Acetylmuramoyl-L-alanine amidase
CR091_RS15720	COG1280	lysine exporter protein (LysE YggA)
CR091_RS15725	COG0531	amino acid
CR091_RS15740	COG3764	Sortase (surface protein transpeptidase)
CR091_RS15745	COG0730	response to heat
CR091_RS15750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS15755	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CR091_RS15765	COG2130	NADP-dependent
CR091_RS15790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR091_RS15805	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CR091_RS15815	COG0501	Belongs to the peptidase M48B family
CR091_RS15850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CR091_RS15860	COG1309	transcriptional regulator
CR091_RS15865	COG2076	Multidrug Resistance protein
CR091_RS15870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CR091_RS15875	COG1278	Cold shock
CR091_RS15880	COG2323	membrane
CR091_RS15895	COG2910	NAD(P)H-binding
CR091_RS15920	COG4607	ABC-type enterochelin transport system periplasmic component
CR091_RS15925	COG4604	ABC transporter, ATP-binding protein
CR091_RS15930	COG4605	iron ion homeostasis
CR091_RS15935	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR091_RS15940	COG3773	Cell wall hydrolase
CR091_RS15960	COG2249	NAD(P)H dehydrogenase (quinone) activity
CR091_RS15965	COG0681	Belongs to the peptidase S26 family
CR091_RS15995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CR091_RS16000	COG1396	sequence-specific DNA binding
CR091_RS16005	COG0861	Integral membrane protein TerC family
CR091_RS16010	COG1609	Transcriptional regulator
CR091_RS16015	COG1959	2 iron, 2 sulfur cluster binding
CR091_RS16035	COG3773	Cell wall hydrolase
CR091_RS16040	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CR091_RS16065	COG3546	catalase activity
CR091_RS16085	COG1280	lysine exporter protein (LysE YggA)
CR091_RS16090	COG1917	Cupin 2, conserved barrel domain protein
CR091_RS16090	COG2207	Transcriptional regulator
CR091_RS16095	COG4585	Histidine kinase
CR091_RS16115	COG3209	COG3209 Rhs family protein
CR091_RS16135	COG1819	glycosyl
CR091_RS16150	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CR091_RS16160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CR091_RS16180	COG0346	lactoylglutathione lyase activity
CR091_RS16195	COG1136	(ABC) transporter
CR091_RS16200	COG0577	efflux transmembrane transporter activity
CR091_RS16205	COG3850	Histidine kinase
CR091_RS16205	COG5002	protein histidine kinase activity
CR091_RS16215	COG0384	phenazine biosynthesis protein PhzF
CR091_RS16230	COG5002	protein histidine kinase activity
CR091_RS16235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS16260	COG4989	oxidoreductase activity
CR091_RS16270	COG0697	spore germination
CR091_RS16275	COG1917	Cupin 2, conserved barrel domain protein
CR091_RS16275	COG2207	Transcriptional regulator
CR091_RS16350	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CR091_RS16360	COG0583	DNA-binding transcription factor activity
CR091_RS16370	COG1301	dicarboxylic acid transport
CR091_RS16375	COG2824	Alkylphosphonate utilization operon protein PhnA
CR091_RS16405	COG0405	Gamma-glutamyltransferase
CR091_RS16410	COG1073	alpha beta
CR091_RS16425	COG0477	Major facilitator Superfamily
CR091_RS16430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS16445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR091_RS16450	COG0745	RESPONSE REGULATOR receiver
CR091_RS16455	COG2205	protein histidine kinase activity
CR091_RS16460	COG1136	(ABC) transporter
CR091_RS16465	COG0577	efflux transmembrane transporter activity
CR091_RS16475	COG0412	Dienelactone hydrolase
CR091_RS16480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CR091_RS16495	COG0730	response to heat
CR091_RS16500	COG0425	Belongs to the sulfur carrier protein TusA family
CR091_RS16505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CR091_RS16505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CR091_RS16510	COG0425	Belongs to the sulfur carrier protein TusA family
CR091_RS16510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CR091_RS16520	COG1054	Belongs to the UPF0176 family
CR091_RS16525	COG2210	Belongs to the sulfur carrier protein TusA family
CR091_RS16530	COG0425	Belongs to the sulfur carrier protein TusA family
CR091_RS16535	COG1937	Protein conserved in bacteria
CR091_RS16565	COG0583	DNA-binding transcription factor activity
CR091_RS16590	COG2188	Transcriptional regulator
CR091_RS16600	COG2723	6-phospho-beta-galactosidase activity
CR091_RS16625	COG1280	lysine exporter protein (LysE YggA)
CR091_RS16630	COG3695	enzyme binding
CR091_RS16640	COG0583	DNA-binding transcription factor activity
CR091_RS16645	COG2814	Major facilitator Superfamily
CR091_RS16660	COG0346	lactoylglutathione lyase activity
CR091_RS16680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CR091_RS16695	COG0778	Nitroreductase
CR091_RS16700	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS16715	COG1704	LemA family
CR091_RS16735	COG1733	regulation of RNA biosynthetic process
CR091_RS16740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CR091_RS16745	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CR091_RS16750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR091_RS16765	COG2304	oxidoreductase activity
CR091_RS16775	COG0346	lactoylglutathione lyase activity
CR091_RS16780	COG2808	Putative FMN-binding domain
CR091_RS16810	COG4807	Protein conserved in bacteria
CR091_RS16820	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CR091_RS16825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR091_RS16830	COG1278	Cold shock
CR091_RS16835	COG1278	Cold shock
CR091_RS16850	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CR091_RS16855	COG2258	MOSC domain
CR091_RS16860	COG2807	transmembrane transport
CR091_RS16865	COG2186	Transcriptional regulator
CR091_RS16915	COG0659	secondary active sulfate transmembrane transporter activity
CR091_RS16925	COG2211	Major facilitator Superfamily
CR091_RS16930	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CR091_RS16935	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CR091_RS16940	COG1691	(AIR) carboxylase
CR091_RS16945	COG1606	tRNA processing
CR091_RS16950	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS16960	COG1904	glucuronate isomerase
CR091_RS17020	COG0772	Belongs to the SEDS family
CR091_RS17055	COG0561	phosphatase activity
CR091_RS17065	COG2312	Erythromycin esterase
CR091_RS17080	COG2329	Antibiotic biosynthesis monooxygenase
CR091_RS17090	COG1404	Belongs to the peptidase S8 family
CR091_RS17105	COG0745	RESPONSE REGULATOR receiver
CR091_RS17120	COG1131	(ABC) transporter
CR091_RS17135	COG0659	secondary active sulfate transmembrane transporter activity
CR091_RS17150	COG2323	membrane
CR091_RS17170	COG0583	DNA-binding transcription factor activity
CR091_RS17175	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS17190	COG1064	alcohol dehydrogenase
CR091_RS17195	COG0789	Transcriptional regulator
CR091_RS17210	COG0662	Cupin 2, conserved barrel domain protein
CR091_RS17230	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS17235	COG1278	Cold shock
CR091_RS17250	COG3290	protein histidine kinase activity
CR091_RS17250	COG0840	transmembrane signaling receptor activity
CR091_RS17255	COG5001	Diguanylate cyclase
CR091_RS17260	COG1876	peptidase activity
CR091_RS17280	COG0598	Magnesium transport protein CorA
CR091_RS17285	COG1366	Belongs to the anti-sigma-factor antagonist family
CR091_RS17295	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS17320	COG4335	DNA alkylation repair
CR091_RS17325	COG0454	-acetyltransferase
CR091_RS17330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CR091_RS17350	COG2186	Transcriptional regulator
CR091_RS17370	COG3619	membrane
CR091_RS17380	COG1349	DNA-binding transcription factor activity
CR091_RS17385	COG0561	phosphatase activity
CR091_RS17395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CR091_RS17415	COG1280	lysine exporter protein (LysE YggA)
CR091_RS17440	COG3153	acetyltransferase
CR091_RS17440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CR091_RS17450	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CR091_RS17475	COG2160	L-arabinose isomerase activity
CR091_RS17490	COG1609	Transcriptional regulator
CR091_RS17495	COG1078	dGTPase activity
CR091_RS17515	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CR091_RS17520	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CR091_RS17525	COG1918	ferrous iron import across plasma membrane
CR091_RS17525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CR091_RS17565	COG1846	Transcriptional regulator
CR091_RS17600	COG0697	spore germination
CR091_RS17605	COG1388	LysM domain
CR091_RS17605	COG0791	NLP P60 protein
CR091_RS17610	COG2258	MOSC domain
CR091_RS17620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CR091_RS17630	COG2610	gluconate transmembrane transporter activity
CR091_RS17635	COG0129	dihydroxy-acid dehydratase activity
CR091_RS17640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CR091_RS17645	COG2271	Major facilitator Superfamily
CR091_RS17660	COG1414	Transcriptional regulator
CR091_RS17710	COG5646	InterPro IPR014922
CR091_RS17715	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CR091_RS17735	COG1278	Cold shock
CR091_RS17740	COG2814	Major facilitator Superfamily
CR091_RS17750	COG0583	DNA-binding transcription factor activity
CR091_RS17760	COG2807	transmembrane transport
CR091_RS17780	COG0604	alcohol dehydrogenase
CR091_RS17790	COG1733	regulation of RNA biosynthetic process
CR091_RS17815	COG4978	Transcriptional regulator
CR091_RS17815	COG0789	Transcriptional regulator
CR091_RS17825	COG2271	Major facilitator Superfamily
CR091_RS17830	COG4948	Mandelate Racemase Muconate Lactonizing
CR091_RS17840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CR091_RS17845	COG1414	Transcriptional regulator
CR091_RS17880	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS17885	COG2249	NAD(P)H dehydrogenase (quinone) activity
CR091_RS17900	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS17905	COG2188	Transcriptional regulator
CR091_RS17915	COG1501	Belongs to the glycosyl hydrolase 31 family
CR091_RS17925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CR091_RS17930	COG2211	Major facilitator Superfamily
CR091_RS17950	COG2311	Membrane
CR091_RS18005	COG0047	phosphoribosylformylglycinamidine synthase activity
CR091_RS18010	COG1522	sequence-specific DNA binding
CR091_RS18030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CR091_RS18035	COG2267	carboxylic ester hydrolase activity
CR091_RS18045	COG1335	isochorismatase
CR091_RS18055	COG0346	lactoylglutathione lyase activity
CR091_RS18060	COG2259	Doxx family
CR091_RS18070	COG1819	glycosyl
CR091_RS18075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CR091_RS18110	COG0477	Major facilitator Superfamily
CR091_RS18125	COG0477	Major facilitator Superfamily
CR091_RS18130	COG1309	transcriptional regulator
CR091_RS18140	COG4572	Cation transport regulator
CR091_RS18145	COG1621	beta-fructofuranosidase activity
CR091_RS18150	COG0366	Alpha amylase catalytic
CR091_RS18155	COG1609	Transcriptional regulator
CR091_RS18210	COG1266	CAAX protease self-immunity
CR091_RS18215	COG0156	8-amino-7-oxononanoate synthase activity
CR091_RS18220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CR091_RS18230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CR091_RS18230	COG1263	PTS System
CR091_RS18240	COG0252	asparaginase activity
CR091_RS18255	COG0686	Belongs to the AlaDH PNT family
CR091_RS18270	COG1695	Transcriptional regulator
CR091_RS18285	COG0671	phosphoesterase, PA-phosphatase related
CR091_RS18290	COG5002	protein histidine kinase activity
CR091_RS18295	COG0745	RESPONSE REGULATOR receiver
CR091_RS18300	COG0745	RESPONSE REGULATOR receiver
CR091_RS18315	COG0583	DNA-binding transcription factor activity
CR091_RS18325	COG2814	Major facilitator Superfamily
CR091_RS18330	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS18345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CR091_RS18350	COG1309	transcriptional regulator
CR091_RS18355	COG0110	maltose O-acetyltransferase activity
CR091_RS18365	COG3620	sequence-specific DNA binding
CR091_RS18460	COG1971	Probably functions as a manganese efflux pump
CR091_RS18465	COG3339	Conserved Protein
CR091_RS18475	COG3708	Transcriptional regulator
CR091_RS18475	COG2207	Transcriptional regulator
CR091_RS18510	COG0303	'Molybdopterin
CR091_RS18520	COG0521	Mo-molybdopterin cofactor biosynthetic process
CR091_RS18525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CR091_RS18550	COG2828	Protein conserved in bacteria
CR091_RS18555	COG0583	DNA-binding transcription factor activity
CR091_RS18560	COG2851	Citrate transporter
CR091_RS18580	COG0670	Belongs to the BI1 family
CR091_RS18600	COG0791	NLP P60 protein
CR091_RS18605	COG2814	Major facilitator Superfamily
CR091_RS18610	COG1846	Transcriptional regulator
CR091_RS18635	COG1278	Cold shock
CR091_RS18650	COG1113	amino acid transport
CR091_RS18655	COG1113	amino acid transport
CR091_RS18660	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS18665	COG0506	proline dehydrogenase activity
CR091_RS18685	COG0860	N-Acetylmuramoyl-L-alanine amidase
CR091_RS18690	COG5001	Diguanylate cyclase
CR091_RS18690	COG3300	MHYT domain
CR091_RS18735	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CR091_RS18740	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CR091_RS18765	COG1247	-acetyltransferase
CR091_RS18775	COG0789	Transcriptional regulator
CR091_RS18780	COG0667	Aldo Keto reductase
CR091_RS18790	COG0789	Transcriptional regulator
CR091_RS18805	COG1621	beta-fructofuranosidase activity
CR091_RS18810	COG4980	gas vesicle protein
CR091_RS18835	COG1752	Esterase of the alpha-beta hydrolase superfamily
CR091_RS18840	COG0577	efflux transmembrane transporter activity
CR091_RS18845	COG1136	(ABC) transporter
CR091_RS18855	COG0642	Histidine kinase
CR091_RS18860	COG0745	RESPONSE REGULATOR receiver
CR091_RS18870	COG1289	transmembrane transporter activity
CR091_RS18875	COG1937	Protein conserved in bacteria
CR091_RS18880	COG3209	COG3209 Rhs family protein
CR091_RS18895	COG3973	AAA domain
CR091_RS18900	COG1024	Enoyl-CoA hydratase
CR091_RS18905	COG1733	regulation of RNA biosynthetic process
CR091_RS18910	COG2124	cytochrome p450
CR091_RS18915	COG2259	Doxx family
CR091_RS18920	COG0463	Glycosyl transferase, family 2
CR091_RS18930	COG0463	Glycosyl transferase, family 2
CR091_RS18945	COG1388	LysM domain
CR091_RS18945	COG0791	NLP P60 protein
CR091_RS18950	COG0840	transmembrane signaling receptor activity
CR091_RS18955	COG1846	Transcriptional regulator
CR091_RS18965	COG1595	DNA-templated transcription, initiation
CR091_RS18970	COG0726	polysaccharide deacetylase
CR091_RS18975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CR091_RS18985	COG0697	spore germination
CR091_RS19000	COG0833	amino acid
CR091_RS19010	COG0405	Gamma-glutamyltransferase
CR091_RS19030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CR091_RS19035	COG0569	domain protein
CR091_RS19045	COG1522	sequence-specific DNA binding
CR091_RS19055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CR091_RS19060	COG0745	RESPONSE REGULATOR receiver
CR091_RS19065	COG2205	protein histidine kinase activity
CR091_RS19065	COG2770	Histidine kinase
CR091_RS19070	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CR091_RS19075	COG1607	acyl-coa hydrolase
CR091_RS19080	COG1802	Transcriptional regulator
CR091_RS19085	COG0697	spore germination
CR091_RS19095	COG0006	proline dipeptidase activity
CR091_RS19115	COG2249	NAD(P)H dehydrogenase (quinone) activity
CR091_RS19120	COG5522	Integral membrane protein (intg_mem_TP0381)
CR091_RS19125	COG1174	glycine betaine transport
CR091_RS19130	COG0517	IMP dehydrogenase activity
CR091_RS19130	COG1125	glycine betaine transport
CR091_RS19145	COG2814	Major facilitator Superfamily
CR091_RS19155	COG0395	ABC-type sugar transport system, permease component
CR091_RS19165	COG1653	transport
CR091_RS19175	COG1609	Transcriptional regulator
CR091_RS19180	COG2205	protein histidine kinase activity
CR091_RS19185	COG0730	response to heat
CR091_RS19190	COG1301	dicarboxylic acid transport
CR091_RS19205	COG0753	catalase activity
CR091_RS19230	COG1368	sulfuric ester hydrolase activity
CR091_RS19240	COG0697	spore germination
CR091_RS19245	COG1902	pentaerythritol trinitrate reductase activity
CR091_RS19260	COG1113	amino acid transport
CR091_RS19265	COG5505	Protein of unknown function (DUF819)
CR091_RS19270	COG1309	transcriptional regulator
CR091_RS19280	COG0583	DNA-binding transcription factor activity
CR091_RS19285	COG0730	response to heat
CR091_RS19290	COG1247	-acetyltransferase
CR091_RS19295	COG2910	NAD(P)H-binding
CR091_RS19305	COG1285	pathogenesis
CR091_RS19315	COG4195	phage-related replication protein
CR091_RS19325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CR091_RS19340	COG1113	amino acid transport
CR091_RS19370	COG0463	Glycosyl transferase, family 2
CR091_RS19390	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CR091_RS19395	COG2514	catechol 2,3-dioxygenase activity
CR091_RS19415	COG1280	lysine exporter protein (LysE YggA)
CR091_RS19420	COG1115	amino acid carrier protein
CR091_RS19430	COG0385	Bile acid
CR091_RS19435	COG0668	transmembrane transport
CR091_RS19440	COG2340	Cysteine-rich secretory protein family
CR091_RS19445	COG1253	flavin adenine dinucleotide binding
CR091_RS19455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CR091_RS19460	COG0589	response to stress
CR091_RS19465	COG0205	6-phosphofructokinase activity
CR091_RS19470	COG0791	NLP P60 protein
CR091_RS19470	COG1388	LysM domain
CR091_RS19480	COG0432	Pfam Uncharacterised protein family UPF0047
CR091_RS19485	COG0697	spore germination
CR091_RS19490	COG0814	amino acid
CR091_RS19515	COG1131	(ABC) transporter
CR091_RS19530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CR091_RS19545	COG0584	glycerophosphoryl diester phosphodiesterase
CR091_RS19555	COG3842	ATPase activity
CR091_RS19570	COG0706	membrane insertase activity
CR091_RS19580	COG1263	PTS System
CR091_RS19580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CR091_RS19585	COG3711	transcriptional antiterminator
CR091_RS19590	COG2190	(PTS) system
CR091_RS19600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CR091_RS19615	COG0772	Belongs to the SEDS family
CR091_RS19620	COG0659	secondary active sulfate transmembrane transporter activity
CR091_RS19625	COG0813	purine-nucleoside phosphorylase activity
CR091_RS19635	COG0671	phosphoesterase, PA-phosphatase related
CR091_RS19640	COG4326	sporulation control protein
CR091_RS19645	COG0515	serine threonine protein kinase
CR091_RS19665	COG4479	Belongs to the UPF0346 family
CR091_RS19670	COG3594	Acyltransferase
CR091_RS19685	COG1509	lysine 2,3-aminomutase activity
CR091_RS19690	COG0456	acetyltransferase
CR091_RS19695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CR091_RS19700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CR091_RS19705	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CR091_RS19710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CR091_RS19715	COG1301	dicarboxylic acid transport
CR091_RS19725	COG4191	Histidine kinase
CR091_RS19750	COG2755	lipolytic protein G-D-S-L family
CR091_RS19755	COG1999	signal sequence binding
CR091_RS19765	COG1307	EDD domain protein, DegV family
CR091_RS19775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CR091_RS19785	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CR091_RS19790	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CR091_RS19795	COG0788	formyltetrahydrofolate deformylase activity
CR091_RS19825	COG0076	glutamate decarboxylase activity
CR091_RS19845	COG0415	Belongs to the DNA photolyase family
CR091_RS19850	COG3852	Histidine kinase
CR091_RS19865	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS19875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CR091_RS19885	COG4846	Membrane protein involved in cytochrome C biogenesis
CR091_RS19890	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CR091_RS19895	COG0785	Cytochrome C biogenesis protein
CR091_RS19905	COG1132	(ABC) transporter
CR091_RS19910	COG1132	(ABC) transporter
CR091_RS19930	COG4224	UPF0291 protein
CR091_RS19935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CR091_RS19970	COG0463	Glycosyl transferase, family 2
CR091_RS19975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CR091_RS19980	COG0531	amino acid
CR091_RS19990	COG0174	glutamine synthetase
CR091_RS19995	COG0789	Transcriptional regulator
CR091_RS20000	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CR091_RS20005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CR091_RS20010	COG2860	membrane
CR091_RS20015	COG0464	growth
CR091_RS20025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CR091_RS20035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CR091_RS20040	COG0531	amino acid
CR091_RS20050	COG4550	Control of competence regulator ComK, YlbF/YmcA
CR091_RS20055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CR091_RS20060	COG1013	pyruvate-flavodoxin oxidoreductase activity
CR091_RS20065	COG0674	pyruvate-flavodoxin oxidoreductase activity
CR091_RS20065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CR091_RS20075	COG2359	stage V sporulation protein S
CR091_RS20080	COG1692	metallophosphoesterase
CR091_RS20090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CR091_RS20095	COG1058	Belongs to the CinA family
CR091_RS20095	COG1546	Belongs to the CinA family
CR091_RS20100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CR091_RS20105	COG1426	Protein conserved in bacteria
CR091_RS20120	COG0300	oxidoreductase activity
CR091_RS20125	COG0612	Peptidase, M16
CR091_RS20130	COG0612	Peptidase, M16
CR091_RS20135	COG1079	Belongs to the binding-protein-dependent transport system permease family
CR091_RS20140	COG4603	Belongs to the binding-protein-dependent transport system permease family
CR091_RS20145	COG3845	ABC transporter
CR091_RS20150	COG1744	ABC transporter substrate-binding protein PnrA-like
CR091_RS20155	COG2188	Transcriptional regulator
CR091_RS20160	COG4980	gas vesicle protein
CR091_RS20160	COG1674	ftsk spoiiie
CR091_RS20170	COG0740	serine-type endopeptidase activity
CR091_RS20175	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CR091_RS20185	COG0527	aspartate kinase activity
CR091_RS20190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CR091_RS20195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CR091_RS20200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CR091_RS20205	COG1873	PFAM PRC-barrel domain
CR091_RS20210	COG0612	Peptidase, M16
CR091_RS20215	COG0726	polysaccharide deacetylase
CR091_RS20220	COG1185	polyribonucleotide nucleotidyltransferase activity
CR091_RS20225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CR091_RS20230	COG0196	riboflavin kinase activity
CR091_RS20240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CR091_RS20245	COG1550	Protein conserved in bacteria
CR091_RS20255	COG1358	cellular component organization or biogenesis
CR091_RS20260	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CR091_RS20265	COG0195	Participates in both transcription termination and antitermination
CR091_RS20270	COG0779	Required for maturation of 30S ribosomal subunits
CR091_RS20275	COG2176	DNA-directed DNA polymerase activity
CR091_RS20280	COG0442	prolyl-tRNA aminoacylation
CR091_RS20285	COG0750	zinc metalloprotease
CR091_RS20295	COG4589	Belongs to the CDS family
CR091_RS20300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CR091_RS20305	COG0233	cytoplasmic translational termination
CR091_RS20315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CR091_RS20330	COG1191	sigma factor activity
CR091_RS20335	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CR091_RS20340	COG0835	chemotaxis
CR091_RS20345	COG2198	Histidine kinase
CR091_RS20345	COG0643	Histidine kinase
CR091_RS20350	COG2201	protein-glutamate methylesterase activity
CR091_RS20355	COG0455	bacterial-type flagellum organization
CR091_RS20360	COG1419	protein localization to endoplasmic reticulum
CR091_RS20365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CR091_RS20370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CR091_RS20375	COG1684	flagellar biosynthetic protein fliR
CR091_RS20380	COG1987	bacterial-type flagellum assembly
CR091_RS20385	COG1338	Plays a role in the flagellum-specific transport system
CR091_RS20390	COG3190	flagellar
CR091_RS20395	COG2201	protein-glutamate methylesterase activity
CR091_RS20400	COG1776	CheC inhibitor of MCP methylation
CR091_RS20400	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CR091_RS20405	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CR091_RS20415	COG1582	Flagellar protein (FlbD)
CR091_RS20420	COG4786	Flagellar basal body rod
CR091_RS20425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CR091_RS20440	COG2882	bacterial-type flagellum organization
CR091_RS20445	COG1157	protein secretion by the type III secretion system
CR091_RS20450	COG1317	bacterial-type flagellum organization
CR091_RS20455	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CR091_RS20460	COG1766	The M ring may be actively involved in energy transduction
CR091_RS20465	COG1677	Flagellar hook-basal body complex protein FliE
CR091_RS20470	COG1558	bacterial-type flagellum-dependent cell motility
CR091_RS20475	COG1815	bacterial-type flagellum-dependent cell motility
CR091_RS20480	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CR091_RS20485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CR091_RS20495	COG4974	Belongs to the 'phage' integrase family
CR091_RS20500	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CR091_RS20505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CR091_RS20510	COG0758	DNA mediated transformation
CR091_RS20515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CR091_RS20520	COG0045	succinate-CoA ligase (ADP-forming) activity
CR091_RS20540	COG0335	large ribosomal subunit rRNA binding
CR091_RS20550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CR091_RS20560	COG1837	Belongs to the UPF0109 family
CR091_RS20565	COG0228	four-way junction DNA binding
CR091_RS20570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CR091_RS20580	COG0552	protein localization to endoplasmic reticulum
CR091_RS20585	COG1196	nuclear chromosome segregation
CR091_RS20590	COG0571	ribonuclease III activity
CR091_RS20600	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS20605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CR091_RS20610	COG0416	fatty acid biosynthetic process
CR091_RS20615	COG1349	DNA-binding transcription factor activity
CR091_RS20620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CR091_RS20625	COG1760	l-serine dehydratase
CR091_RS20630	COG1760	l-serine dehydratase
CR091_RS20640	COG1461	Dihydroxyacetone kinase
CR091_RS20645	COG1302	Protein conserved in bacteria
CR091_RS20650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CR091_RS20660	COG1564	THIamine pyrophosphokinase
CR091_RS20665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CR091_RS20670	COG1162	GTPase activity
CR091_RS20675	COG2815	serine threonine protein kinase
CR091_RS20675	COG0515	serine threonine protein kinase
CR091_RS20680	COG0631	protein serine/threonine phosphatase activity
CR091_RS20690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CR091_RS20690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CR091_RS20695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CR091_RS20705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CR091_RS20710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CR091_RS20715	COG1758	RNA polymerase activity
CR091_RS20720	COG0194	GDP metabolic process
CR091_RS20725	COG2052	Domain of unknown function (DUF370)
CR091_RS20730	COG1561	YicC-like family, N-terminal region
CR091_RS20735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CR091_RS20745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CR091_RS20760	COG0543	2 iron, 2 sulfur cluster binding
CR091_RS20775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CR091_RS20780	COG0540	Belongs to the ATCase OTCase family
CR091_RS20790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CR091_RS20795	COG0564	pseudouridine synthase activity
CR091_RS20800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CR091_RS20815	COG3599	regulation of cell shape
CR091_RS20820	COG2302	S4 RNA-binding domain
CR091_RS20825	COG0762	integral membrane protein
CR091_RS20830	COG1799	cell septum assembly
CR091_RS20835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CR091_RS20845	COG1873	PFAM PRC-barrel domain
CR091_RS20850	COG1191	sigma factor activity
CR091_RS20855	COG1191	sigma factor activity
CR091_RS20865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CR091_RS20870	COG0849	cell division
CR091_RS20875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CR091_RS20880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CR091_RS20885	COG0772	Belongs to the SEDS family
CR091_RS20890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CR091_RS20895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CR091_RS20900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CR091_RS20905	COG0768	penicillin binding
CR091_RS20910	COG0768	penicillin binding
CR091_RS20915	COG4839	cell division protein FtsL
CR091_RS20925	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CR091_RS20935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CR091_RS20940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CR091_RS20945	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CR091_RS20950	COG0439	Biotin carboxylase
CR091_RS20955	COG0454	-acetyltransferase
CR091_RS20965	COG1024	Enoyl-CoA hydratase
CR091_RS20970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CR091_RS20975	COG1399	metal-binding, possibly nucleic acid-binding protein
CR091_RS20980	COG1323	Belongs to the UPF0348 family
CR091_RS20985	COG3480	Lon protease (S16) C-terminal proteolytic domain
CR091_RS20990	COG1752	Esterase of the alpha-beta hydrolase superfamily
CR091_RS20995	COG3314	Sporulation integral membrane protein YlbJ
CR091_RS21000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CR091_RS21005	COG0742	ribosomal rna small subunit methyltransferase
CR091_RS21015	COG4471	UPF0298 protein
CR091_RS21025	COG3679	Belongs to the UPF0342 family
CR091_RS21045	COG4347	Protein of unknown function (DUF1405)
CR091_RS21055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CR091_RS21070	COG5582	Belongs to the UPF0302 family
CR091_RS21075	COG0457	Tetratricopeptide repeat
CR091_RS21085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CR091_RS21090	COG0287	Prephenate dehydrogenase
CR091_RS21095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CR091_RS21100	COG0159	tryptophan synthase activity
CR091_RS21110	COG0134	indole-3-glycerol-phosphate synthase activity
CR091_RS21115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CR091_RS21125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CR091_RS21130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CR091_RS21135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CR091_RS21140	COG0105	UTP biosynthetic process
CR091_RS21145	COG0142	geranyltranstransferase activity
CR091_RS21150	COG2226	methyltransferase
CR091_RS21155	COG0142	geranyltranstransferase activity
CR091_RS21165	COG0302	gtp cyclohydrolase
CR091_RS21170	COG0776	regulation of translation
CR091_RS21175	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CR091_RS21210	COG2271	Major facilitator Superfamily
CR091_RS21215	COG1304	FMN binding
CR091_RS21220	COG0539	negative regulation of cytoplasmic translation
CR091_RS21230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CR091_RS21240	COG2959	enzyme of heme biosynthesis
CR091_RS21245	COG3409	Peptidoglycan-binding domain 1 protein
CR091_RS21245	COG3773	Cell wall hydrolase
CR091_RS21250	COG2339	peptidase activity
CR091_RS21255	COG0252	asparaginase activity
CR091_RS21260	COG0492	ferredoxin-NADP+ reductase activity
CR091_RS21265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CR091_RS21270	COG4862	establishment of competence for transformation
CR091_RS21275	COG0789	Transcriptional regulator
CR091_RS21280	COG1408	metallophosphoesterase
CR091_RS21295	COG1266	CAAX protease self-immunity
CR091_RS21300	COG0514	ATP-dependent DNA helicase (RecQ)
CR091_RS21310	COG1141	Ferredoxin
CR091_RS21315	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CR091_RS21320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CR091_RS21325	COG0739	heme binding
CR091_RS21330	COG5002	protein histidine kinase activity
CR091_RS21335	COG0745	RESPONSE REGULATOR receiver
CR091_RS21340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CR091_RS21345	COG1333	cytochrome c biogenesis protein
CR091_RS21350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CR091_RS21355	COG1187	pseudouridine synthase activity
CR091_RS21360	COG0700	Nucleoside recognition
CR091_RS21365	COG2715	membrane protein required for spore maturation
CR091_RS21370	COG1686	Belongs to the peptidase S11 family
CR091_RS21375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CR091_RS21380	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CR091_RS21390	COG1547	Domain of unknown function (DUF309)
CR091_RS21400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CR091_RS21405	COG4086	secreted protein
CR091_RS21415	COG0697	spore germination
CR091_RS21430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CR091_RS21465	COG1686	Belongs to the peptidase S11 family
CR091_RS21480	COG4974	Belongs to the 'phage' integrase family
CR091_RS21490	COG0735	belongs to the Fur family
CR091_RS21495	COG1300	Membrane
CR091_RS21500	COG0494	nUDIX hydrolase
CR091_RS21510	COG0667	Aldo Keto reductase
CR091_RS21525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CR091_RS21535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CR091_RS21540	COG1073	alpha beta
CR091_RS21555	COG0300	oxidoreductase activity
CR091_RS21560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CR091_RS21565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CR091_RS21570	COG1902	pentaerythritol trinitrate reductase activity
CR091_RS21580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CR091_RS21585	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS21590	COG2508	Transcriptional regulator
CR091_RS21610	COG0167	dihydroorotate dehydrogenase activity
CR091_RS21610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CR091_RS21615	COG0493	'glutamate synthase
CR091_RS21620	COG2195	Cleaves the N-terminal amino acid of tripeptides
CR091_RS21625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CR091_RS21635	COG1376	ErfK ybiS ycfS ynhG family protein
CR091_RS21640	COG4129	membrane
CR091_RS21645	COG1126	abc transporter atp-binding protein
CR091_RS21650	COG0765	amino acid transport
CR091_RS21655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR091_RS21665	COG1703	isobutyryl-CoA mutase activity
CR091_RS21670	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CR091_RS21670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CR091_RS21675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CR091_RS21675	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CR091_RS21680	COG0508	dehydrogenase complex catalyzes the overall conversion of
CR091_RS21685	COG0022	dehydrogenase e1 component
CR091_RS21690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CR091_RS21695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CR091_RS21710	COG0280	phosphate acetyltransferase
CR091_RS21715	COG3290	protein histidine kinase activity
CR091_RS21715	COG3829	transcription factor binding
CR091_RS21725	COG0584	glycerophosphoryl diester phosphodiesterase
CR091_RS21730	COG3093	addiction module antidote protein HigA
CR091_RS21735	COG3104	oligopeptide transport
CR091_RS21740	COG0745	RESPONSE REGULATOR receiver
CR091_RS21745	COG0750	zinc metalloprotease
CR091_RS21750	COG0497	DNA recombination
CR091_RS21760	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CR091_RS21775	COG1722	exodeoxyribonuclease VII activity
CR091_RS21785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CR091_RS21790	COG1302	Protein conserved in bacteria
CR091_RS21795	COG0439	Biotin carboxylase
CR091_RS21800	COG0511	ligase activity, forming carbon-carbon bonds
CR091_RS21840	COG3854	ATPases associated with a variety of cellular activities
CR091_RS21850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CR091_RS21855	COG0006	proline dipeptidase activity
CR091_RS21860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CR091_RS21870	COG3872	metal-dependent enzyme
CR091_RS21880	COG1752	Esterase of the alpha-beta hydrolase superfamily
CR091_RS21885	COG1321	iron dependent repressor
CR091_RS21890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CR091_RS21895	COG0095	Lipoate-protein ligase
CR091_RS21900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CR091_RS21910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CR091_RS21915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CR091_RS21920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CR091_RS21950	COG4970	Tfp pilus assembly protein FimT
CR091_RS21955	COG4537	Required for transformation and DNA binding
CR091_RS21960	COG1459	type II secretion system
CR091_RS21965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CR091_RS21970	COG1393	Belongs to the ArsC family
CR091_RS21980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CR091_RS21990	COG2866	Carboxypeptidase
CR091_RS21995	COG1940	carbohydrate kinase activity
CR091_RS22000	COG4483	Protein conserved in bacteria
CR091_RS22005	COG0705	Rhomboid family
CR091_RS22005	COG0457	Tetratricopeptide repeat
CR091_RS22015	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CR091_RS22025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CR091_RS22040	COG0704	Plays a role in the regulation of phosphate uptake
CR091_RS22050	COG0768	penicillin binding
CR091_RS22055	COG0477	Major facilitator Superfamily
CR091_RS22090	COG2839	Protein conserved in bacteria
CR091_RS22095	COG1283	sodium-dependent phosphate transmembrane transporter activity
CR091_RS22105	COG2814	Major facilitator Superfamily
CR091_RS22110	COG1388	LysM domain
CR091_RS22115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CR091_RS22120	COG4709	membrane
CR091_RS22125	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CR091_RS22130	COG0735	belongs to the Fur family
CR091_RS22135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CR091_RS22140	COG1121	(ABC) transporter
CR091_RS22150	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CR091_RS22155	COG0513	Belongs to the DEAD box helicase family
CR091_RS22165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CR091_RS22170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CR091_RS22175	COG2384	SAM-dependent methyltransferase
CR091_RS22180	COG2010	Cytochrome c
CR091_RS22185	COG1960	acyl-CoA dehydrogenase activity
CR091_RS22190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CR091_RS22195	COG0358	DNA primase activity
CR091_RS22200	COG1671	Belongs to the UPF0178 family
CR091_RS22205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CR091_RS22210	COG0517	IMP dehydrogenase activity
CR091_RS22225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CR091_RS22230	COG0295	cytidine deaminase activity
CR091_RS22235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CR091_RS22245	COG1480	7TM receptor with intracellular HD hydrolase
CR091_RS22250	COG1702	phosphate starvation-inducible protein PhoH
CR091_RS22275	COG1030	water channel activity
CR091_RS22280	COG1610	YqeY-like protein
CR091_RS22290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CR091_RS22295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CR091_RS22300	COG2264	protein methyltransferase activity
CR091_RS22315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CR091_RS22320	COG1420	regulation of RNA biosynthetic process
CR091_RS22325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CR091_RS22330	COG0481	GTPase activity
CR091_RS22340	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CR091_RS22345	COG0268	Binds directly to 16S ribosomal RNA
CR091_RS22350	COG1466	dna polymerase III delta subunit
CR091_RS22360	COG0658	competence protein
CR091_RS22360	COG2333	competence protein COMEC
CR091_RS22365	COG2131	deaminase
CR091_RS22370	COG1555	photosystem II stabilization
CR091_RS22370	COG1596	polysaccharide export
CR091_RS22375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CR091_RS22380	COG2226	methyltransferase
CR091_RS22385	COG0799	negative regulation of ribosome biogenesis
CR091_RS22390	COG1713	HD superfamily hydrolase involved in NAD metabolism
CR091_RS22395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CR091_RS22400	COG1534	Rna-binding protein
CR091_RS22405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CR091_RS22410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CR091_RS22415	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CR091_RS22425	COG0688	phosphatidylethanolamine metabolic process
CR091_RS22430	COG1183	phosphatidylcholine synthase activity
CR091_RS22450	COG0626	cystathionine gamma-synthase activity
CR091_RS22455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CR091_RS22460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CR091_RS22465	COG2226	methyltransferase
CR091_RS22480	COG0768	penicillin binding
CR091_RS22485	COG1335	isochorismatase
CR091_RS22490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CR091_RS22495	COG0572	uridine kinase
CR091_RS22500	COG0826	peptidase U32
CR091_RS22505	COG0826	peptidase U32
CR091_RS22510	COG4122	O-methyltransferase activity
CR091_RS22515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CR091_RS22520	COG3906	Belongs to the UPF0473 family
CR091_RS22530	COG4472	Bacterial protein of unknown function (DUF965)
CR091_RS22540	COG0628	permease
CR091_RS22555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CR091_RS22565	COG0482	sulfurtransferase activity
CR091_RS22570	COG1104	cysteine desulfurase activity
CR091_RS22575	COG1959	2 iron, 2 sulfur cluster binding
CR091_RS22580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CR091_RS22585	COG0581	inorganic phosphate transmembrane transporter activity
CR091_RS22590	COG0573	inorganic phosphate transmembrane transporter activity
CR091_RS22595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CR091_RS22600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CR091_RS22610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CR091_RS22615	COG0124	histidyl-tRNA synthetase
CR091_RS22625	COG0860	N-Acetylmuramoyl-L-alanine amidase
CR091_RS22630	COG1490	D-aminoacyl-tRNA deacylase activity
CR091_RS22635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CR091_RS22640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CR091_RS22645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CR091_RS22645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CR091_RS22650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CR091_RS22650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CR091_RS22660	COG2244	polysaccharide biosynthetic process
CR091_RS22665	COG2323	membrane
CR091_RS22675	COG1862	Preprotein translocase
CR091_RS22680	COG0343	queuine tRNA-ribosyltransferase activity
CR091_RS22685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CR091_RS22695	COG2255	four-way junction helicase activity
CR091_RS22700	COG0632	four-way junction helicase activity
CR091_RS22725	COG1388	LysM domain
CR091_RS22730	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CR091_RS22735	COG0157	Belongs to the NadC ModD family
CR091_RS22740	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CR091_RS22745	COG1104	cysteine desulfurase activity
CR091_RS22750	COG1827	regulation of RNA biosynthetic process
CR091_RS22755	COG0077	Prephenate dehydratase
CR091_RS22760	COG4492	Belongs to the UPF0735 family
CR091_RS22765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CR091_RS22770	COG3290	protein histidine kinase activity
CR091_RS22780	COG2868	ribosomal protein
CR091_RS22795	COG1994	Peptidase M50
CR091_RS22800	COG0739	heme binding
CR091_RS22805	COG2894	cell division
CR091_RS22810	COG0850	regulation of cytokinetic process
CR091_RS22815	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CR091_RS22820	COG1792	Involved in formation and maintenance of cell shape
CR091_RS22825	COG1077	Cell shape determining protein MreB Mrl
CR091_RS22830	COG2003	Belongs to the UPF0758 family
CR091_RS22845	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CR091_RS22855	COG2322	membrane
CR091_RS22860	COG0285	dihydrofolate synthase activity
CR091_RS22865	COG0525	valine-tRNA ligase activity
CR091_RS22875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CR091_RS22880	COG1388	LysM domain
CR091_RS22885	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CR091_RS22890	COG0113	porphobilinogen synthase activity
CR091_RS22895	COG1587	Uroporphyrinogen-III synthase
CR091_RS22900	COG0181	hydroxymethylbilane synthase activity
CR091_RS22905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CR091_RS22920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CR091_RS22925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CR091_RS22930	COG0470	DNA polymerase III
CR091_RS22930	COG1067	ATP-dependent peptidase activity
CR091_RS22935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CR091_RS22940	COG0544	peptidyl-prolyl cis-trans isomerase activity
CR091_RS22945	COG1477	protein flavinylation
CR091_RS22945	COG0457	Tetratricopeptide repeat
CR091_RS22950	COG0066	3-isopropylmalate dehydratase activity
CR091_RS22955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CR091_RS22965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CR091_RS22970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CR091_RS22975	COG0440	acetolactate synthase activity
CR091_RS22980	COG0028	Belongs to the TPP enzyme family
CR091_RS22990	COG0622	Phosphoesterase
CR091_RS22995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CR091_RS23005	COG5401	PFAM Sporulation and spore germination
CR091_RS23010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CR091_RS23015	COG1846	Transcriptional regulator
CR091_RS23025	COG0306	phosphate transporter
CR091_RS23030	COG1392	Phosphate transport regulator
CR091_RS23035	COG0768	penicillin binding
CR091_RS23045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR091_RS23050	COG0431	NADPH-dependent FMN reductase
CR091_RS23055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CR091_RS23060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CR091_RS23065	COG1116	anion transmembrane transporter activity
CR091_RS23070	COG0475	glutathione-regulated potassium exporter activity
CR091_RS23075	COG0490	domain, Protein
CR091_RS23085	COG2197	response regulator
CR091_RS23090	COG0824	Thioesterase
CR091_RS23095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CR091_RS23100	COG1053	succinate dehydrogenase
CR091_RS23105	COG2009	succinate dehydrogenase
CR091_RS23110	COG1719	4-vinyl reductase, 4VR
CR091_RS23115	COG0527	aspartate kinase activity
CR091_RS23125	COG3118	belongs to the thioredoxin family
CR091_RS23135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CR091_RS23140	COG2086	electron transfer activity
CR091_RS23145	COG1024	Enoyl-CoA hydratase
CR091_RS23150	COG1309	transcriptional regulator
CR091_RS23155	COG0318	PFAM AMP-dependent synthetase and ligase
CR091_RS23160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CR091_RS23170	COG3766	membrane
CR091_RS23175	COG1193	negative regulation of DNA recombination
CR091_RS23180	COG1796	DNA polymerase
CR091_RS23180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CR091_RS23185	COG1286	toxin biosynthetic process
CR091_RS23190	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CR091_RS23195	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CR091_RS23200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CR091_RS23200	COG0072	phenylalanine-tRNA ligase activity
CR091_RS23205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CR091_RS23210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CR091_RS23220	COG1363	Peptidase, m42
CR091_RS23240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CR091_RS23245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CR091_RS23250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CR091_RS23255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CR091_RS23265	COG1484	DNA-dependent DNA replication
CR091_RS23270	COG3611	Membrane attachment protein
CR091_RS23275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CR091_RS23285	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CR091_RS23290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CR091_RS23300	COG1971	Probably functions as a manganese efflux pump
CR091_RS23305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CR091_RS23310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CR091_RS23310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CR091_RS23315	COG5002	protein histidine kinase activity
CR091_RS23320	COG0745	RESPONSE REGULATOR receiver
CR091_RS23330	COG0039	L-malate dehydrogenase activity
CR091_RS23335	COG0538	isocitrate dehydrogenase activity
CR091_RS23340	COG0372	Belongs to the citrate synthase family
CR091_RS23345	COG2707	UPF0756 membrane protein
CR091_RS23350	COG0628	permease
CR091_RS23355	COG3030	protein affecting phage T7 exclusion by the F plasmid
CR091_RS23365	COG0825	malonyl-CoA metabolic process
CR091_RS23370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CR091_RS23375	COG2186	Transcriptional regulator
CR091_RS23380	COG0281	malic enzyme
CR091_RS23385	COG0587	DNA-directed DNA polymerase activity
CR091_RS23400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CR091_RS23410	COG4109	DRTGG domain
CR091_RS23420	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CR091_RS23430	COG0165	Argininosuccinate lyase
CR091_RS23435	COG0137	argininosuccinate synthase activity
CR091_RS23450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CR091_RS23455	COG0827	DNA restriction-modification system
CR091_RS23460	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CR091_RS23465	COG3874	Sporulation protein YtfJ
CR091_RS23480	COG1714	RDD family
CR091_RS23485	COG0616	signal peptide processing
CR091_RS23490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CR091_RS23495	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CR091_RS23505	COG0301	tRNA thio-modification
CR091_RS23510	COG1104	cysteine desulfurase activity
CR091_RS23515	COG1114	Component of the transport system for branched-chain amino acids
CR091_RS23520	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CR091_RS23525	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CR091_RS23530	COG1309	transcriptional regulator
CR091_RS23535	COG1956	GAF domain-containing protein
CR091_RS23550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CR091_RS23555	COG0454	-acetyltransferase
CR091_RS23560	COG0517	IMP dehydrogenase activity
CR091_RS23565	COG0123	including yeast histone deacetylase and acetoin utilization protein
CR091_RS23585	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CR091_RS23585	COG1605	Chorismate mutase
CR091_RS23590	COG3118	belongs to the thioredoxin family
CR091_RS23595	COG4980	gas vesicle protein
CR091_RS23610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CR091_RS23620	COG1674	ftsk spoiiie
CR091_RS23625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CR091_RS23630	COG4848	Belongs to the UPF0354 family
CR091_RS23635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CR091_RS23640	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CR091_RS23645	COG1363	Peptidase, m42
CR091_RS23650	COG5584	Small secreted protein
CR091_RS23655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CR091_RS23660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CR091_RS23670	COG0510	thiamine kinase activity
CR091_RS23675	COG1523	belongs to the glycosyl hydrolase 13 family
CR091_RS23685	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CR091_RS23690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CR091_RS23700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CR091_RS23705	COG1349	DNA-binding transcription factor activity
CR091_RS23710	COG1187	pseudouridine synthase activity
CR091_RS23715	COG2244	polysaccharide biosynthetic process
CR091_RS23720	COG2081	HI0933 family
CR091_RS23730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CR091_RS23735	COG0495	leucyl-tRNA aminoacylation
CR091_RS23740	COG2610	gluconate transmembrane transporter activity
CR091_RS23745	COG2814	Major facilitator Superfamily
CR091_RS23760	COG1242	4 iron, 4 sulfur cluster binding
CR091_RS23765	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CR091_RS23775	COG2267	carboxylic ester hydrolase activity
CR091_RS23780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CR091_RS23785	COG0671	phosphoesterase, PA-phosphatase related
CR091_RS23790	COG0438	transferase activity, transferring glycosyl groups
CR091_RS23790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CR091_RS23795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CR091_RS23800	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CR091_RS23810	COG1506	peptidase
CR091_RS23815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CR091_RS23820	COG1116	anion transmembrane transporter activity
CR091_RS23825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CR091_RS23830	COG0494	nUDIX hydrolase
CR091_RS23840	COG4824	toxin secretion phage lysis holin
CR091_RS23845	COG0783	Belongs to the Dps family
CR091_RS23855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CR091_RS23860	COG0288	reversible hydration of carbon dioxide
CR091_RS23865	COG0523	cobalamin synthesis protein
CR091_RS23875	COG0254	rRNA binding
CR091_RS23880	COG1271	oxidase subunit
CR091_RS23885	COG1294	oxidase, subunit
CR091_RS23890	COG0716	FMN binding
CR091_RS23915	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CR091_RS23920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CR091_RS23925	COG4948	Mandelate Racemase Muconate Lactonizing
CR091_RS23930	COG0318	PFAM AMP-dependent synthetase and ligase
CR091_RS23935	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CR091_RS23940	COG0596	Alpha beta hydrolase
CR091_RS23945	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CR091_RS23950	COG1169	isochorismate synthase
CR091_RS23955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CR091_RS23965	COG0058	SHG alpha-glucan phosphorylase activity
CR091_RS23970	COG0297	glycogen (starch) synthase activity
CR091_RS23975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CR091_RS23980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CR091_RS24110	COG0318	PFAM AMP-dependent synthetase and ligase
CR091_RS24115	COG1285	pathogenesis
CR091_RS24135	COG0529	Catalyzes the synthesis of activated sulfate
CR091_RS24145	COG0306	phosphate transporter
CR091_RS24155	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CR091_RS24160	COG0346	lactoylglutathione lyase activity
CR091_RS24165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CR091_RS24175	COG0166	Belongs to the GPI family
CR091_RS24185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CR091_RS24185	COG2111	Na H antiporter
CR091_RS24190	COG2111	Na H antiporter
CR091_RS24195	COG1006	Multisubunit Na H antiporter MnhC subunit
CR091_RS24200	COG0651	ATP synthesis coupled electron transport
CR091_RS24205	COG1863	multisubunit Na H antiporter MnhE subunit
CR091_RS24210	COG2212	antiporter activity
CR091_RS24215	COG1320	monovalent cation:proton antiporter activity
CR091_RS24220	COG1979	alcohol dehydrogenase
CR091_RS24225	COG2155	Conserved Protein
CR091_RS24230	COG1098	S1 RNA binding domain
CR091_RS24235	COG0436	Aminotransferase
CR091_RS24240	COG1522	sequence-specific DNA binding
CR091_RS24245	COG2267	carboxylic ester hydrolase activity
CR091_RS24250	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CR091_RS24255	COG2032	superoxide dismutase activity
CR091_RS24270	COG5018	Exonuclease
CR091_RS24275	COG2050	protein possibly involved in aromatic compounds catabolism
CR091_RS24285	COG1418	mRNA catabolic process
CR091_RS24295	COG2056	Na+-H+ antiporter family
CR091_RS24300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CR091_RS24305	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CR091_RS24310	COG3584	3D domain protein
CR091_RS24320	COG1252	NADH dehydrogenase
CR091_RS24325	COG0492	ferredoxin-NADP+ reductase activity
CR091_RS24335	COG0316	Belongs to the HesB IscA family
CR091_RS24340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CR091_RS24345	COG4844	belongs to the
CR091_RS24350	COG1252	NADH dehydrogenase
CR091_RS24355	COG4837	Protein of unknown function (DUF1462)
CR091_RS24360	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CR091_RS24365	COG0083	homoserine kinase activity
CR091_RS24370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CR091_RS24375	COG0460	homoserine dehydrogenase
CR091_RS24380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CR091_RS24385	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CR091_RS24390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CR091_RS24395	COG0647	UMP catabolic process
CR091_RS24400	COG2445	Protein of unknown function DUF86
CR091_RS24410	COG4470	Protein conserved in bacteria
CR091_RS24425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CR091_RS24430	COG0739	heme binding
CR091_RS24435	COG0733	neurotransmitter:sodium symporter activity
CR091_RS24445	COG3377	Domain of unknown function (DUF1805)
CR091_RS24450	COG1801	Protein of unknown function DUF72
CR091_RS24455	COG0719	Fe-S assembly protein
CR091_RS24460	COG0822	iron-sulfur transferase activity
CR091_RS24465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CR091_RS24470	COG0719	Fe-S assembly protein
CR091_RS24475	COG0396	ATPase activity
CR091_RS24480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CR091_RS24485	COG1464	Belongs to the NlpA lipoprotein family
CR091_RS24490	COG2011	ABC-type metal ion transport system permease component
CR091_RS24495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CR091_RS24500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CR091_RS24505	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CR091_RS24515	COG0509	glycine decarboxylation via glycine cleavage system
CR091_RS24520	COG1393	Belongs to the ArsC family
CR091_RS24525	COG1960	acyl-CoA dehydrogenase activity
CR091_RS24530	COG0183	Belongs to the thiolase family
CR091_RS24535	COG1250	3-hydroxyacyl-CoA dehydrogenase
CR091_RS24535	COG1024	Enoyl-CoA hydratase
CR091_RS24560	COG1120	ATPase activity
CR091_RS24565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR091_RS24570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR091_RS24575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CR091_RS24585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CR091_RS24590	COG1309	transcriptional regulator
CR091_RS24600	COG1028	Short-chain dehydrogenase reductase Sdr
CR091_RS24605	COG0477	Major facilitator Superfamily
CR091_RS24610	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CR091_RS24615	COG0583	DNA-binding transcription factor activity
CR091_RS24625	COG0672	)-iron permease
CR091_RS24630	COG3850	Histidine kinase
CR091_RS24630	COG5002	protein histidine kinase activity
CR091_RS24635	COG0745	RESPONSE REGULATOR receiver
CR091_RS24640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CR091_RS24645	COG0671	phosphoesterase, PA-phosphatase related
CR091_RS24650	COG1846	Transcriptional regulator
CR091_RS24655	COG0778	Nitroreductase
CR091_RS24660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CR091_RS24665	COG0314	molybdopterin synthase activity
CR091_RS24670	COG1763	Mo-molybdopterin cofactor biosynthetic process
CR091_RS24675	COG0303	'Molybdopterin
CR091_RS24680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CR091_RS24685	COG0746	molybdenum cofactor guanylyltransferase activity
CR091_RS24695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CR091_RS24700	COG5609	conserved protein (DUF2294)
CR091_RS24705	COG3383	formate dehydrogenase (NAD+) activity
CR091_RS24710	COG2427	Protein of unknown function (DUF1641)
CR091_RS24715	COG0725	ABC transporter, periplasmic molybdate-binding protein
CR091_RS24720	COG4149	molybdate abc transporter
CR091_RS24730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CR091_RS24735	COG0557	exoribonuclease II activity
CR091_RS24740	COG1647	Serine aminopeptidase, S33
CR091_RS24745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CR091_RS24785	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CR091_RS24805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CR091_RS24815	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CR091_RS24820	COG1660	Displays ATPase and GTPase activities
CR091_RS24825	COG1051	belongs to the nudix hydrolase family
CR091_RS24830	COG0492	ferredoxin-NADP+ reductase activity
CR091_RS24835	COG0457	Tetratricopeptide repeat
CR091_RS24840	COG0140	phosphoribosyl-ATP diphosphatase activity
CR091_RS24840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CR091_RS24845	COG0107	imidazoleglycerol-phosphate synthase activity
CR091_RS24850	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CR091_RS24855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CR091_RS24860	COG0131	Imidazoleglycerol-phosphate dehydratase
CR091_RS24865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CR091_RS24870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CR091_RS24875	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CR091_RS24880	COG0110	maltose O-acetyltransferase activity
CR091_RS24885	COG0546	phosphoglycolate phosphatase activity
CR091_RS24890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CR091_RS24895	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CR091_RS24900	COG1950	PFAM Membrane protein of
CR091_RS24910	COG3595	metallopeptidase activity
CR091_RS24920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CR091_RS24925	COG0556	nucleotide-excision repair
CR091_RS24930	COG2204	response regulator
CR091_RS24935	COG0506	proline dehydrogenase activity
CR091_RS24940	COG4897	Protein conserved in bacteria
CR091_RS24945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CR091_RS24950	COG3409	Peptidoglycan-binding domain 1 protein
CR091_RS24950	COG0793	Belongs to the peptidase S41A family
CR091_RS24955	COG0739	heme binding
CR091_RS24960	COG2177	Part of the ABC transporter FtsEX involved in
CR091_RS24965	COG2884	Cell division ATP-binding protein ftsE
CR091_RS24970	COG0655	NAD(P)H dehydrogenase (quinone) activity
CR091_RS24980	COG0805	protein transport
CR091_RS24985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CR091_RS24990	COG3540	Alkaline phosphatase
CR091_RS25000	COG0653	protein targeting
CR091_RS25010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CR091_RS25020	COG1516	flagellar protein fliS
CR091_RS25025	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CR091_RS25035	COG1113	amino acid transport
CR091_RS25045	COG1012	belongs to the aldehyde dehydrogenase family
CR091_RS25050	COG1454	alcohol dehydrogenase
CR091_RS25055	COG1510	regulation of RNA biosynthetic process
CR091_RS25060	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CR091_RS25065	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CR091_RS25070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CR091_RS25075	COG1256	bacterial-type flagellum assembly
CR091_RS25075	COG4786	Flagellar basal body rod
CR091_RS25095	COG1040	competence protein
CR091_RS25100	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CR091_RS25105	COG1307	EDD domain protein, DegV family
CR091_RS25110	COG1728	Protein conserved in bacteria
CR091_RS25120	COG2197	response regulator
CR091_RS25125	COG4585	Histidine kinase
CR091_RS25130	COG1739	Uncharacterized protein family UPF0029
CR091_RS25135	COG1316	TRANSCRIPTIONal
CR091_RS25140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CR091_RS25145	COG1585	Membrane protein implicated in regulation of membrane protease activity
CR091_RS25150	COG2268	Band 7 protein
CR091_RS25165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CR091_RS25175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CR091_RS25180	COG1388	LysM domain
CR091_RS25180	COG0791	NLP P60 protein
CR091_RS25185	COG0629	single-stranded DNA binding
CR091_RS25205	COG4786	Flagellar basal body rod
CR091_RS25210	COG4786	Flagellar basal body rod
CR091_RS25215	COG1077	Cell shape determining protein MreB Mrl
CR091_RS25220	COG1609	Transcriptional regulator
CR091_RS25225	COG0739	heme binding
CR091_RS25230	COG2385	sporulation resulting in formation of a cellular spore
CR091_RS25245	COG4836	Membrane
CR091_RS25250	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CR091_RS25255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CR091_RS25260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CR091_RS25265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CR091_RS25270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CR091_RS25275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CR091_RS25280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CR091_RS25285	COG0356	it plays a direct role in the translocation of protons across the membrane
CR091_RS25300	COG1404	Belongs to the peptidase S8 family
CR091_RS25305	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CR091_RS25310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CR091_RS25325	COG0698	ribose 5-phosphate isomerase
CR091_RS25335	COG1971	Probably functions as a manganese efflux pump
CR091_RS25340	COG0009	L-threonylcarbamoyladenylate synthase
CR091_RS25360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CR091_RS25375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CR091_RS25385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CR091_RS25390	COG0191	fructose-bisphosphate aldolase activity
CR091_RS25395	COG2204	response regulator
CR091_RS25400	COG4821	SIS domain
CR091_RS25405	COG0504	CTP synthase activity
CR091_RS25415	COG1703	isobutyryl-CoA mutase activity
CR091_RS25415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CR091_RS25415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CR091_RS25425	COG1960	acyl-CoA dehydrogenase activity
CR091_RS25430	COG1960	acyl-CoA dehydrogenase activity
CR091_RS25435	COG1250	3-hydroxyacyl-CoA dehydrogenase
CR091_RS25440	COG0183	Belongs to the thiolase family
CR091_RS25445	COG0247	lactate metabolic process
CR091_RS25445	COG2181	nitrate reductase activity
CR091_RS25450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CR091_RS25455	COG4294	response to UV
CR091_RS25460	COG0018	arginyl-trna synthetase
CR091_RS25465	COG4506	Protein conserved in bacteria
CR091_RS25470	COG0010	Belongs to the arginase family
CR091_RS25475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CR091_RS25480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CR091_RS25490	COG1994	Peptidase M50
CR091_RS25495	COG1942	4-Oxalocrotonate Tautomerase
CR091_RS25500	COG3465	dGTPase activity
CR091_RS25505	COG1078	dGTPase activity
CR091_RS25510	COG4844	belongs to the
CR091_RS25520	COG0095	Lipoate-protein ligase
CR091_RS25525	COG0280	phosphate acetyltransferase
CR091_RS25530	COG3253	May function as heme-dependent peroxidase
CR091_RS25535	COG3773	Cell wall hydrolase
CR091_RS25545	COG2363	Small membrane protein
CR091_RS25555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CR091_RS25565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CR091_RS25570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CR091_RS25575	COG2508	Transcriptional regulator
CR091_RS25575	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CR091_RS25580	COG0686	Belongs to the AlaDH PNT family
CR091_RS25590	COG0351	phosphomethylpyrimidine kinase
CR091_RS25595	COG0561	phosphatase activity
CR091_RS25600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CR091_RS25605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CR091_RS25605	COG1263	PTS System
CR091_RS25605	COG2190	(PTS) system
CR091_RS25615	COG0438	transferase activity, transferring glycosyl groups
CR091_RS25630	COG2076	Multidrug Resistance protein
CR091_RS25640	COG0728	peptidoglycan biosynthetic process
CR091_RS25655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CR091_RS25660	COG4988	ABC transporter
CR091_RS25665	COG1294	oxidase, subunit
CR091_RS25670	COG1271	oxidase subunit
CR091_RS25675	COG3610	response to peptide
CR091_RS25680	COG2966	Psort location CytoplasmicMembrane, score
CR091_RS25685	COG1609	Transcriptional regulator
CR091_RS25695	COG2814	Major facilitator Superfamily
CR091_RS25710	COG1966	Carbon starvation protein
CR091_RS25715	COG0753	catalase activity
CR091_RS25730	COG0471	metal ion transport
CR091_RS25735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CR091_RS25750	COG3850	Histidine kinase
CR091_RS25750	COG5002	protein histidine kinase activity
CR091_RS25765	COG0494	nUDIX hydrolase
CR091_RS25775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CR091_RS25780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CR091_RS25790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CR091_RS25795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CR091_RS25800	COG4853	Protein conserved in bacteria
CR091_RS25810	COG5002	protein histidine kinase activity
CR091_RS25815	COG0745	RESPONSE REGULATOR receiver
CR091_RS25840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CR091_RS25845	COG0305	Participates in initiation and elongation during chromosome replication
CR091_RS25855	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CR091_RS25865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CR091_RS25875	COG0360	Binds together with S18 to 16S ribosomal RNA
CR091_RS25880	COG0012	GTP binding
CR091_RS25885	COG4481	Protein conserved in bacteria
CR091_RS25890	COG0668	transmembrane transport
CR091_RS25895	COG3949	Membrane
CR091_RS25905	COG1475	DNA binding
CR091_RS25910	COG1192	Involved in chromosome partitioning
CR091_RS25915	COG1475	DNA binding
CR091_RS25925	COG0445	tRNA wobble uridine modification
CR091_RS25930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CR091_RS25935	COG1847	R3H domain protein
CR091_RS25940	COG0706	membrane insertase activity
CR091_RS25945	COG0594	ribonuclease P activity
CR091_RS25950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CR091_RS25960	COG0772	Belongs to the SEDS family
CR091_RS25975	COG3279	Response regulator of the LytR AlgR family
CR091_RS26100	COG1376	ErfK ybiS ycfS ynhG family protein
CR091_RS26160	COG0741	lytic transglycosylase activity
CR091_RS26160	COG0791	NLP P60 protein
CR091_RS26190	COG3505	Type IV secretory pathway VirD4
CR091_RS26235	COG2197	response regulator
CR091_RS26240	COG3852	Histidine kinase
CR091_RS26245	COG1073	alpha beta
CR091_RS26285	COG1714	RDD family
CR091_RS26310	COG2333	competence protein COMEC
CR091_RS26310	COG0658	competence protein
CR091_RS26325	COG2318	DinB family
CR091_RS26375	COG1215	transferase activity, transferring glycosyl groups
CR091_RS26400	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CR091_RS26405	COG0419	ATPase involved in DNA repair
CR091_RS26485	COG1132	(ABC) transporter
CR091_RS26490	COG0515	serine threonine protein kinase
CR091_RS26515	COG1695	Transcriptional regulator
CR091_RS26520	COG3279	Response regulator of the LytR AlgR family
CR091_RS26585	COG2002	toxin-antitoxin pair type II binding
CR091_RS26610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CR091_RS26620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CR091_RS26645	COG1253	flavin adenine dinucleotide binding
CR091_RS26665	COG0640	Transcriptional regulator
CR091_RS26730	COG0277	FAD linked oxidase domain protein
CR091_RS26885	COG0328	RNA-DNA hybrid ribonuclease activity
CR091_RS26920	COG4974	Belongs to the 'phage' integrase family
CR091_RS26995	COG0438	transferase activity, transferring glycosyl groups
CR091_RS27050	COG1216	Glycosyl transferase, family 2
CR091_RS27065	COG1216	Glycosyl transferase, family 2
CR091_RS27100	COG1086	Polysaccharide biosynthesis protein