locus-tag	class	description
S101359_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S101359_RS00010	COG0592	DNA-directed DNA polymerase activity
S101359_RS00015	COG2501	S4 domain
S101359_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S101359_RS00030	COG0187	DNA topoisomerase II activity
S101359_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S101359_RS00070	COG0517	IMP dehydrogenase activity
S101359_RS00070	COG0516	GMP reductase activity
S101359_RS00075	COG1686	Belongs to the peptidase S11 family
S101359_RS00100	COG1428	Deoxynucleoside kinase
S101359_RS00105	COG1428	Deoxynucleoside kinase
S101359_RS00110	COG1388	LysM domain
S101359_RS00110	COG3858	chitin binding
S101359_RS00115	COG1335	isochorismatase
S101359_RS00120	COG0590	tRNA wobble adenosine to inosine editing
S101359_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S101359_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S101359_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S101359_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
S101359_RS00190	COG3853	Toxic anion resistance protein (TelA)
S101359_RS00195	COG1982	Orn Lys Arg decarboxylase major
S101359_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S101359_RS00205	COG3870	Protein conserved in bacteria
S101359_RS00210	COG1728	Protein conserved in bacteria
S101359_RS00215	COG0470	DNA polymerase III
S101359_RS00220	COG1774	PSP1 C-terminal conserved region
S101359_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S101359_RS00235	COG2827	Endonuclease containing a URI domain
S101359_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S101359_RS00245	COG2002	toxin-antitoxin pair type II binding
S101359_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101359_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101359_RS00255	COG0084	hydrolase, TatD family'
S101359_RS00260	COG3583	domain protein
S101359_RS00260	COG3584	3D domain protein
S101359_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S101359_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S101359_RS00280	COG4466	Protein conserved in bacteria
S101359_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S101359_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101359_RS00300	COG0251	oxidation-reduction process
S101359_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S101359_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S101359_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
S101359_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S101359_RS00340	COG2002	toxin-antitoxin pair type II binding
S101359_RS00345	COG2244	polysaccharide biosynthetic process
S101359_RS00350	COG3956	TIGRFAM MazG family protein
S101359_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S101359_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S101359_RS00375	COG1098	S1 RNA binding domain
S101359_RS00390	COG2208	phosphoserine phosphatase activity
S101359_RS00395	COG2304	oxidoreductase activity
S101359_RS00400	COG0515	serine threonine protein kinase
S101359_RS00405	COG0037	tRNA processing
S101359_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
S101359_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S101359_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S101359_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101359_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S101359_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
S101359_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101359_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S101359_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S101359_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S101359_RS00470	COG1396	sequence-specific DNA binding
S101359_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S101359_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S101359_RS00560	COG4463	regulation of RNA biosynthetic process
S101359_RS00565	COG3880	PFAM UvrB UvrC protein
S101359_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
S101359_RS00575	COG0542	response to heat
S101359_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S101359_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
S101359_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
S101359_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S101359_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S101359_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S101359_RS00610	COG1045	serine acetyltransferase
S101359_RS00615	COG0215	cysteine-tRNA ligase activity
S101359_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S101359_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S101359_RS00630	COG3688	RNA-binding protein containing a PIN domain
S101359_RS00635	COG1595	DNA-templated transcription, initiation
S101359_RS00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S101359_RS00650	COG0250	Participates in transcription elongation, termination and antitermination
S101359_RS00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S101359_RS00675	COG2813	Specifically methylates the guanine in position
S101359_RS00680	COG0085	RNA polymerase activity
S101359_RS00690	COG1358	cellular component organization or biogenesis
S101359_RS00700	COG0049	tRNA binding
S101359_RS00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S101359_RS00715	COG0596	Alpha beta hydrolase
S101359_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S101359_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S101359_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S101359_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S101359_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S101359_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S101359_RS00820	COG0200	Binds to the 23S rRNA
S101359_RS00825	COG0201	protein transport
S101359_RS00835	COG0024	Methionine aminopeptidase
S101359_RS00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
S101359_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S101359_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S101359_RS00870	COG0203	ribosomal protein L17
S101359_RS00875	COG1122	ATPase activity
S101359_RS00880	COG1122	ATPase activity
S101359_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S101359_RS00890	COG0101	tRNA pseudouridine synthase activity
S101359_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S101359_RS00905	COG2226	methyltransferase
S101359_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101359_RS00920	COG0489	protein tyrosine kinase activity
S101359_RS00930	COG2194	sulfuric ester hydrolase activity
S101359_RS00935	COG0726	polysaccharide deacetylase
S101359_RS00965	COG0738	Major facilitator superfamily
S101359_RS00970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S101359_RS00980	COG1063	alcohol dehydrogenase
S101359_RS00985	COG0659	secondary active sulfate transmembrane transporter activity
S101359_RS00990	COG0385	Bile acid
S101359_RS00995	COG2819	hydrolase of the alpha beta superfamily
S101359_RS01000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS01005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS01010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101359_RS01015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101359_RS01015	COG2207	Transcriptional regulator
S101359_RS01020	COG3876	Protein conserved in bacteria
S101359_RS01025	COG1472	Belongs to the glycosyl hydrolase 3 family
S101359_RS01030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101359_RS01035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101359_RS01035	COG1263	PTS System
S101359_RS01040	COG1737	Transcriptional regulator
S101359_RS01045	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S101359_RS01050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101359_RS01055	COG1683	Conserved Protein
S101359_RS01085	COG1595	DNA-templated transcription, initiation
S101359_RS01090	COG5662	AntiSigma factor
S101359_RS01095	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S101359_RS01100	COG4856	YbbR-like protein
S101359_RS01105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S101359_RS01115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S101359_RS01120	COG3002	Belongs to the UPF0753 family
S101359_RS01125	COG0288	reversible hydration of carbon dioxide
S101359_RS01135	COG5609	conserved protein (DUF2294)
S101359_RS01140	COG0640	Transcriptional regulator
S101359_RS01145	COG2814	Major facilitator Superfamily
S101359_RS01155	COG1413	lyase activity
S101359_RS01180	COG0076	glutamate decarboxylase activity
S101359_RS01185	COG4974	Belongs to the 'phage' integrase family
S101359_RS01195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101359_RS01200	COG2808	Putative FMN-binding domain
S101359_RS01205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S101359_RS01220	COG1346	cytolysis
S101359_RS01225	COG1380	Effector of murein hydrolase LrgA
S101359_RS01230	COG1846	Transcriptional regulator
S101359_RS01235	COG1113	amino acid transport
S101359_RS01250	COG2602	Beta-lactamase
S101359_RS01255	COG2124	cytochrome p450
S101359_RS01265	COG1283	sodium-dependent phosphate transmembrane transporter activity
S101359_RS01270	COG0584	glycerophosphoryl diester phosphodiesterase
S101359_RS01285	COG0584	glycerophosphoryl diester phosphodiesterase
S101359_RS01290	COG2271	Major facilitator Superfamily
S101359_RS01315	COG3409	Peptidoglycan-binding domain 1 protein
S101359_RS01325	COG0371	Dehydrogenase
S101359_RS01330	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
S101359_RS01340	COG0596	Alpha beta hydrolase
S101359_RS01345	COG1183	phosphatidylcholine synthase activity
S101359_RS01350	COG0586	Pfam SNARE associated Golgi protein
S101359_RS01355	COG0688	phosphatidylethanolamine metabolic process
S101359_RS01360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101359_RS01370	COG1404	Belongs to the peptidase S8 family
S101359_RS01380	COG2207	Transcriptional regulator
S101359_RS01385	COG1054	Belongs to the UPF0176 family
S101359_RS01390	COG1301	dicarboxylic acid transport
S101359_RS01395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101359_RS01395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101359_RS01395	COG1263	PTS System
S101359_RS01395	COG1263	PTS System
S101359_RS01395	COG2190	(PTS) system
S101359_RS01395	COG2190	(PTS) system
S101359_RS01400	COG0363	glucosamine-6-phosphate deaminase activity
S101359_RS01405	COG2188	Transcriptional regulator
S101359_RS01415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101359_RS01420	COG0833	amino acid
S101359_RS01425	COG2040	homocysteine
S101359_RS01430	COG1115	amino acid carrier protein
S101359_RS01435	COG2066	Belongs to the glutaminase family
S101359_RS01440	COG4191	Histidine kinase
S101359_RS01445	COG0784	Response regulator, receiver
S101359_RS01450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S101359_RS01455	COG1012	belongs to the aldehyde dehydrogenase family
S101359_RS01460	COG2271	Major facilitator Superfamily
S101359_RS01465	COG4948	Mandelate Racemase Muconate Lactonizing
S101359_RS01470	COG2186	Transcriptional regulator
S101359_RS01475	COG2721	sulfolactate sulfo-lyase activity
S101359_RS01480	COG3173	Aminoglycoside phosphotransferase
S101359_RS01495	COG0745	RESPONSE REGULATOR receiver
S101359_RS01500	COG2205	protein histidine kinase activity
S101359_RS01505	COG1131	(ABC) transporter
S101359_RS01530	COG3773	Cell wall hydrolase
S101359_RS01535	COG3540	Alkaline phosphatase
S101359_RS01540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101359_RS01545	COG0805	protein transport
S101359_RS01555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S101359_RS01560	COG0477	Major facilitator Superfamily
S101359_RS01565	COG1309	transcriptional regulator
S101359_RS01570	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S101359_RS01575	COG1405	negative regulation of cell septum assembly
S101359_RS01575	COG3012	SEC-C Motif Domain Protein
S101359_RS01580	COG0667	Aldo Keto reductase
S101359_RS01590	COG1595	DNA-templated transcription, initiation
S101359_RS01595	COG0735	belongs to the Fur family
S101359_RS01600	COG1595	DNA-templated transcription, initiation
S101359_RS01605	COG1876	peptidase activity
S101359_RS01610	COG0457	Tetratricopeptide repeat
S101359_RS01615	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS01620	COG0366	Alpha amylase catalytic
S101359_RS01625	COG0803	Belongs to the bacterial solute-binding protein 9 family
S101359_RS01630	COG1121	(ABC) transporter
S101359_RS01635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101359_RS01640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101359_RS01645	COG2310	stress, protein
S101359_RS01650	COG2310	stress, protein
S101359_RS01655	COG2310	stress, protein
S101359_RS01660	COG0861	Integral membrane protein TerC family
S101359_RS01690	COG3853	Toxic anion resistance protein (TelA)
S101359_RS01695	COG0477	Major facilitator Superfamily
S101359_RS01705	COG4175	Glycine betaine
S101359_RS01705	COG0517	IMP dehydrogenase activity
S101359_RS01710	COG4176	ABC-type proline glycine betaine transport system permease component
S101359_RS01715	COG2113	Glycine betaine
S101359_RS01720	COG1473	amidohydrolase
S101359_RS01725	COG1288	antiporter activity
S101359_RS01735	COG0039	L-malate dehydrogenase activity
S101359_RS01740	COG1620	l-lactate permease
S101359_RS01745	COG2814	Major facilitator Superfamily
S101359_RS01750	COG1846	Transcriptional regulator
S101359_RS01755	COG1280	lysine exporter protein (LysE YggA)
S101359_RS01760	COG3403	YqcI/YcgG family
S101359_RS01765	COG1113	amino acid transport
S101359_RS01770	COG3665	Urea carboxylase-associated protein
S101359_RS01780	COG1660	Displays ATPase and GTPase activities
S101359_RS01785	COG1082	Xylose isomerase domain protein TIM barrel
S101359_RS01790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S101359_RS01800	COG3458	cephalosporin-C deacetylase activity
S101359_RS01805	COG3541	Predicted nucleotidyltransferase
S101359_RS01810	COG0506	proline dehydrogenase activity
S101359_RS01815	COG1012	belongs to the aldehyde dehydrogenase family
S101359_RS01820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101359_RS01825	COG2508	Transcriptional regulator
S101359_RS01830	COG3689	TIGRFAM TIGR03943 family protein
S101359_RS01835	COG0701	Predicted permease
S101359_RS01840	COG2267	carboxylic ester hydrolase activity
S101359_RS01845	COG0492	ferredoxin-NADP+ reductase activity
S101359_RS01850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S101359_RS01850	COG1587	Uroporphyrinogen-III synthase
S101359_RS01855	COG2146	nitrite reductase [NAD(P)H] activity
S101359_RS01860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S101359_RS01865	COG0243	molybdopterin cofactor binding
S101359_RS01870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S101359_RS01875	COG2223	nitrite transmembrane transporter activity
S101359_RS01880	COG1469	GTP cyclohydrolase I activity
S101359_RS01885	COG1376	ErfK ybiS ycfS ynhG family protein
S101359_RS01890	COG0523	cobalamin synthesis protein
S101359_RS01895	COG0765	amino acid transport
S101359_RS01900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101359_RS01905	COG1063	alcohol dehydrogenase
S101359_RS01910	COG1714	RDD family
S101359_RS01930	COG2723	6-phospho-beta-galactosidase activity
S101359_RS01940	COG3209	COG3209 Rhs family protein
S101359_RS01945	COG3290	protein histidine kinase activity
S101359_RS01945	COG0840	transmembrane signaling receptor activity
S101359_RS01950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
S101359_RS01955	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
S101359_RS01960	COG1733	regulation of RNA biosynthetic process
S101359_RS01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS01975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS01980	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S101359_RS01990	COG0697	spore germination
S101359_RS01995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101359_RS02005	COG2364	Membrane
S101359_RS02010	COG1126	abc transporter atp-binding protein
S101359_RS02015	COG0765	amino acid transport
S101359_RS02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101359_RS02025	COG0583	DNA-binding transcription factor activity
S101359_RS02030	COG0163	prenyltransferase activity
S101359_RS02035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S101359_RS02050	COG0596	Alpha beta hydrolase
S101359_RS02055	COG3104	oligopeptide transport
S101359_RS02060	COG5434	Belongs to the glycosyl hydrolase 28 family
S101359_RS02070	COG0697	spore germination
S101359_RS02080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S101359_RS02085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101359_RS02090	COG0456	acetyltransferase
S101359_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101359_RS02100	COG0765	amino acid transport
S101359_RS02105	COG1126	abc transporter atp-binding protein
S101359_RS02110	COG1473	amidohydrolase
S101359_RS02115	COG2079	MmgE PrpD family protein
S101359_RS02120	COG1136	(ABC) transporter
S101359_RS02125	COG0577	efflux transmembrane transporter activity
S101359_RS02130	COG0745	RESPONSE REGULATOR receiver
S101359_RS02135	COG3850	Histidine kinase
S101359_RS02135	COG5002	protein histidine kinase activity
S101359_RS02140	COG0457	Tetratricopeptide repeat
S101359_RS02160	COG0527	aspartate kinase activity
S101359_RS02165	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS02170	COG4605	iron ion homeostasis
S101359_RS02175	COG4604	ABC transporter, ATP-binding protein
S101359_RS02180	COG4607	ABC-type enterochelin transport system periplasmic component
S101359_RS02185	COG2814	Major facilitator Superfamily
S101359_RS02190	COG1309	transcriptional regulator
S101359_RS02195	COG0457	Tetratricopeptide repeat
S101359_RS02200	COG0778	Nitroreductase
S101359_RS02205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S101359_RS02210	COG0640	Transcriptional regulator
S101359_RS02220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S101359_RS02225	COG1012	belongs to the aldehyde dehydrogenase family
S101359_RS02230	COG4975	Glucose uptake
S101359_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS02240	COG4549	nuclear export factor GLE1
S101359_RS02245	COG1276	copper resistance
S101359_RS02245	COG2372	response to copper ion
S101359_RS02250	COG1349	DNA-binding transcription factor activity
S101359_RS02260	COG2213	PTS system mannitol-specific
S101359_RS02265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101359_RS02270	COG0246	Mannitol dehydrogenase
S101359_RS02275	COG0412	Dienelactone hydrolase
S101359_RS02280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S101359_RS02295	COG0561	phosphatase activity
S101359_RS02300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S101359_RS02305	COG1914	H( )-stimulated, divalent metal cation uptake system
S101359_RS02310	COG4336	lyase activity
S101359_RS02315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S101359_RS02320	COG1984	allophanate hydrolase subunit 2
S101359_RS02325	COG1414	Transcriptional regulator
S101359_RS02330	COG2755	lipolytic protein G-D-S-L family
S101359_RS02340	COG2329	Antibiotic biosynthesis monooxygenase
S101359_RS02345	COG0768	penicillin binding
S101359_RS02350	COG4989	oxidoreductase activity
S101359_RS02355	COG3711	transcriptional antiterminator
S101359_RS02360	COG0318	PFAM AMP-dependent synthetase and ligase
S101359_RS02365	COG2226	methyltransferase
S101359_RS02370	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS02375	COG1917	Cupin 2, conserved barrel domain protein
S101359_RS02380	COG3871	stress protein (general stress protein 26)
S101359_RS02395	COG2814	Major facilitator Superfamily
S101359_RS02410	COG1522	sequence-specific DNA binding
S101359_RS02415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S101359_RS02415	COG0551	DNA topoisomerase type I activity
S101359_RS02420	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
S101359_RS02425	COG3706	GGDEF domain
S101359_RS02430	COG5298	Protein conserved in bacteria
S101359_RS02435	COG1215	transferase activity, transferring glycosyl groups
S101359_RS02445	COG0531	amino acid
S101359_RS02455	COG0028	Belongs to the TPP enzyme family
S101359_RS02465	COG1914	H( )-stimulated, divalent metal cation uptake system
S101359_RS02470	COG2261	transglycosylase associated protein
S101359_RS02475	COG4876	unkown
S101359_RS02480	COG2217	Heavy metal translocating P-type atpase
S101359_RS02485	COG3729	General stress protein
S101359_RS02490	COG0662	Cupin 2, conserved barrel domain protein
S101359_RS02500	COG3546	catalase activity
S101359_RS02505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S101359_RS02510	COG3290	protein histidine kinase activity
S101359_RS02515	COG4565	transcriptional regulatory protein
S101359_RS02520	COG1301	dicarboxylic acid transport
S101359_RS02525	COG0628	permease
S101359_RS02530	COG1131	(ABC) transporter
S101359_RS02535	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101359_RS02545	COG1960	acyl-CoA dehydrogenase activity
S101359_RS02560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S101359_RS02565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101359_RS02570	COG1181	Belongs to the D-alanine--D-alanine ligase family
S101359_RS02575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S101359_RS02585	COG0513	Belongs to the DEAD box helicase family
S101359_RS02590	COG3402	PFAM membrane-flanked domain
S101359_RS02595	COG3428	Bacterial PH domain
S101359_RS02600	COG0705	Rhomboid family
S101359_RS02605	COG0736	holo-[acyl-carrier-protein] synthase activity
S101359_RS02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S101359_RS02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S101359_RS02620	COG0864	Transcriptional regulator
S101359_RS02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
S101359_RS02630	COG1366	Belongs to the anti-sigma-factor antagonist family
S101359_RS02635	COG1366	Belongs to the anti-sigma-factor antagonist family
S101359_RS02640	COG2172	sigma factor antagonist activity
S101359_RS02645	COG2208	phosphoserine phosphatase activity
S101359_RS02650	COG1366	Belongs to the anti-sigma-factor antagonist family
S101359_RS02655	COG2172	sigma factor antagonist activity
S101359_RS02660	COG1191	sigma factor activity
S101359_RS02665	COG2208	phosphoserine phosphatase activity
S101359_RS02670	COG2183	response to ionizing radiation
S101359_RS02680	COG3091	SprT-like family
S101359_RS02720	COG1309	transcriptional regulator
S101359_RS02740	COG3048	D-serine ammonia-lyase activity
S101359_RS02750	COG1316	TRANSCRIPTIONal
S101359_RS02765	COG5002	protein histidine kinase activity
S101359_RS02770	COG0745	RESPONSE REGULATOR receiver
S101359_RS02780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101359_RS02785	COG1522	sequence-specific DNA binding
S101359_RS02790	COG1335	isochorismatase
S101359_RS02795	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S101359_RS02800	COG2814	Major facilitator Superfamily
S101359_RS02805	COG3239	Fatty acid desaturase
S101359_RS02815	COG1278	Cold shock
S101359_RS02825	COG2315	Protein conserved in bacteria
S101359_RS02830	COG2364	Membrane
S101359_RS02835	COG1846	Transcriptional regulator
S101359_RS02840	COG0456	acetyltransferase
S101359_RS02845	COG0697	spore germination
S101359_RS02850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101359_RS02860	COG2814	Major facilitator Superfamily
S101359_RS02870	COG0697	spore germination
S101359_RS02875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101359_RS02880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101359_RS02885	COG0640	Transcriptional regulator
S101359_RS02890	COG0640	Transcriptional regulator
S101359_RS02895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S101359_RS02900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101359_RS02910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101359_RS02920	COG1846	Transcriptional regulator
S101359_RS02925	COG2409	Drug exporters of the RND superfamily
S101359_RS02925	COG1033	growth of symbiont in host cell
S101359_RS02930	COG3711	transcriptional antiterminator
S101359_RS02930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101359_RS02935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101359_RS02935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101359_RS02935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101359_RS02940	COG1482	cell wall glycoprotein biosynthetic process
S101359_RS02945	COG2030	dehydratase
S101359_RS02950	COG0697	spore germination
S101359_RS02955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101359_RS02960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101359_RS02970	COG1522	sequence-specific DNA binding
S101359_RS02980	COG0488	(ABC) transporter
S101359_RS02985	COG0596	Alpha beta hydrolase
S101359_RS03000	COG2602	Beta-lactamase
S101359_RS03010	COG2814	Major facilitator Superfamily
S101359_RS03020	COG1388	LysM domain
S101359_RS03020	COG3858	chitin binding
S101359_RS03025	COG1819	glycosyl
S101359_RS03040	COG1785	Belongs to the alkaline phosphatase family
S101359_RS03050	COG0517	IMP dehydrogenase activity
S101359_RS03050	COG1125	glycine betaine transport
S101359_RS03055	COG1174	glycine betaine transport
S101359_RS03060	COG5434	Belongs to the glycosyl hydrolase 28 family
S101359_RS03065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101359_RS03080	COG2814	Major facilitator Superfamily
S101359_RS03085	COG2186	Transcriptional regulator
S101359_RS03090	COG2807	transmembrane transport
S101359_RS03105	COG1378	Sugar-specific transcriptional regulator TrmB
S101359_RS03150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S101359_RS03155	COG0802	atpase or kinase
S101359_RS03160	COG1214	PFAM Peptidase M22, glycoprotease
S101359_RS03165	COG0456	acetyltransferase
S101359_RS03170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S101359_RS03175	COG0488	(ABC) transporter
S101359_RS03180	COG0315	cyclic pyranopterin monophosphate synthase activity
S101359_RS03190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101359_RS03195	COG0805	protein transport
S101359_RS03205	COG1266	CAAX protease self-immunity
S101359_RS03235	COG0457	Tetratricopeptide repeat
S101359_RS03240	COG1063	alcohol dehydrogenase
S101359_RS03245	COG2211	Major facilitator Superfamily
S101359_RS03250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101359_RS03255	COG1842	Phage shock protein A
S101359_RS03260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S101359_RS03265	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
S101359_RS03270	COG4260	virion core protein, lumpy skin disease virus
S101359_RS03280	COG1595	DNA-templated transcription, initiation
S101359_RS03290	COG0778	Nitroreductase
S101359_RS03295	COG1846	Transcriptional regulator
S101359_RS03300	COG2814	Major facilitator Superfamily
S101359_RS03305	COG1063	alcohol dehydrogenase
S101359_RS03310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S101359_RS03315	COG0823	Involved in the tonB-independent uptake of proteins
S101359_RS03325	COG2267	carboxylic ester hydrolase activity
S101359_RS03335	COG2132	Multicopper oxidase
S101359_RS03340	COG1113	amino acid transport
S101359_RS03350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S101359_RS03355	COG0714	Associated with various cellular activities
S101359_RS03360	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
S101359_RS03365	COG1305	Transglutaminase-like
S101359_RS03385	COG2252	PERMEase
S101359_RS03390	COG3064	Membrane
S101359_RS03400	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
S101359_RS03410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S101359_RS03415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S101359_RS03420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S101359_RS03425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S101359_RS03430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S101359_RS03435	COG0047	phosphoribosylformylglycinamidine synthase activity
S101359_RS03440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S101359_RS03445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S101359_RS03455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S101359_RS03460	COG0138	bifunctional purine biosynthesis protein purh
S101359_RS03465	COG0151	Belongs to the GarS family
S101359_RS03470	COG1522	sequence-specific DNA binding
S101359_RS03475	COG0531	amino acid
S101359_RS03485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S101359_RS03490	COG1470	cell adhesion involved in biofilm formation
S101359_RS03495	COG4496	protein, YerC YecD
S101359_RS03500	COG0069	glutamate synthase activity
S101359_RS03505	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
S101359_RS03510	COG0210	DNA helicase
S101359_RS03515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S101359_RS03520	COG4851	CamS sex pheromone cAM373 precursor
S101359_RS03525	COG2211	Major facilitator Superfamily
S101359_RS03535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101359_RS03545	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S101359_RS03550	COG1250	3-hydroxyacyl-CoA dehydrogenase
S101359_RS03595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101359_RS03600	COG1785	Belongs to the alkaline phosphatase family
S101359_RS03605	COG1285	pathogenesis
S101359_RS03610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101359_RS03620	COG0154	amidase activity
S101359_RS03630	COG1309	transcriptional regulator
S101359_RS03635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S101359_RS03640	COG1597	lipid kinase activity
S101359_RS03645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101359_RS03710	COG5444	nuclease activity
S101359_RS03720	COG0457	Tetratricopeptide repeat
S101359_RS03745	COG3546	catalase activity
S101359_RS03750	COG0454	-acetyltransferase
S101359_RS03760	COG5578	integral membrane protein
S101359_RS03765	COG2972	Histidine kinase
S101359_RS03770	COG2207	Transcriptional regulator
S101359_RS03770	COG4753	response regulator
S101359_RS03775	COG1653	transport
S101359_RS03780	COG1175	transmembrane transport
S101359_RS03785	COG0395	ABC-type sugar transport system, permease component
S101359_RS03790	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S101359_RS03795	COG2207	Transcriptional regulator
S101359_RS03800	COG2755	lipolytic protein G-D-S-L family
S101359_RS03810	COG5578	integral membrane protein
S101359_RS03815	COG3401	FG-GAP repeat protein
S101359_RS03820	COG3401	FG-GAP repeat protein
S101359_RS03825	COG0667	Aldo Keto reductase
S101359_RS03830	COG2755	lipolytic protein G-D-S-L family
S101359_RS03835	COG1874	Beta-galactosidase
S101359_RS03845	COG1653	transport
S101359_RS03850	COG4209	transmembrane transport
S101359_RS03855	COG0395	ABC-type sugar transport system, permease component
S101359_RS03860	COG1486	melibiose metabolic process
S101359_RS03865	COG2323	membrane
S101359_RS03870	COG2329	Antibiotic biosynthesis monooxygenase
S101359_RS03875	COG0346	lactoylglutathione lyase activity
S101359_RS03880	COG1366	Belongs to the anti-sigma-factor antagonist family
S101359_RS03885	COG5583	Uncharacterized small protein (DUF2292)
S101359_RS03890	COG0196	riboflavin kinase activity
S101359_RS03895	COG0670	Belongs to the BI1 family
S101359_RS03905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S101359_RS03905	COG2124	cytochrome p450
S101359_RS03910	COG1368	sulfuric ester hydrolase activity
S101359_RS03915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S101359_RS03925	COG1442	glycosyl transferase family 8
S101359_RS03930	COG1216	Glycosyl transferase, family 2
S101359_RS03935	COG1442	glycosyl transferase family 8
S101359_RS03940	COG2223	nitrite transmembrane transporter activity
S101359_RS03945	COG0531	amino acid
S101359_RS03950	COG1012	belongs to the aldehyde dehydrogenase family
S101359_RS03955	COG0840	transmembrane signaling receptor activity
S101359_RS03960	COG0463	Glycosyl transferase, family 2
S101359_RS03965	COG0488	(ABC) transporter
S101359_RS03970	COG0789	Transcriptional regulator
S101359_RS03975	COG2814	Major facilitator Superfamily
S101359_RS03980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101359_RS03985	COG0488	(ABC) transporter
S101359_RS03990	COG0513	Belongs to the DEAD box helicase family
S101359_RS03995	COG2130	NADP-dependent
S101359_RS04000	COG1120	ATPase activity
S101359_RS04005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS04010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS04015	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S101359_RS04030	COG3866	Pectate lyase
S101359_RS04040	COG0471	metal ion transport
S101359_RS04045	COG3290	protein histidine kinase activity
S101359_RS04050	COG4565	transcriptional regulatory protein
S101359_RS04055	COG3181	Tripartite tricarboxylate transporter family receptor
S101359_RS04060	COG2851	Citrate transporter
S101359_RS04065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101359_RS04070	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
S101359_RS04075	COG1254	Belongs to the acylphosphatase family
S101359_RS04080	COG2258	MOSC domain
S101359_RS04100	COG0024	Methionine aminopeptidase
S101359_RS04105	COG1263	PTS System
S101359_RS04105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101359_RS04110	COG1368	sulfuric ester hydrolase activity
S101359_RS04120	COG1115	amino acid carrier protein
S101359_RS04125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101359_RS04125	COG1263	PTS System
S101359_RS04130	COG0366	Alpha amylase catalytic
S101359_RS04135	COG2188	Transcriptional regulator
S101359_RS04140	COG0778	Nitroreductase
S101359_RS04145	COG0737	Belongs to the 5'-nucleotidase family
S101359_RS04150	COG0693	protein deglycase activity
S101359_RS04155	COG1609	Transcriptional regulator
S101359_RS04160	COG2814	Major facilitator Superfamily
S101359_RS04165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S101359_RS04175	COG2814	Major facilitator Superfamily
S101359_RS04180	COG4840	Belongs to the UPF0435 family
S101359_RS04185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101359_RS04190	COG4980	gas vesicle protein
S101359_RS04195	COG1295	ribonuclease BN
S101359_RS04200	COG0477	Major facilitator Superfamily
S101359_RS04205	COG0387	Pfam Sodium calcium exchanger
S101359_RS04215	COG0668	transmembrane transport
S101359_RS04220	COG0535	radical SAM domain protein
S101359_RS04230	COG0726	polysaccharide deacetylase
S101359_RS04235	COG2084	Dehydrogenase
S101359_RS04245	COG0598	Magnesium transport protein CorA
S101359_RS04250	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S101359_RS04260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101359_RS04265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S101359_RS04270	COG4637	Psort location Cytoplasmic, score
S101359_RS04280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101359_RS04285	COG0022	dehydrogenase e1 component
S101359_RS04290	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101359_RS04295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101359_RS04300	COG3284	Transcriptional regulator
S101359_RS04330	COG4842	Belongs to the WXG100 family
S101359_RS04335	COG1486	melibiose metabolic process
S101359_RS04340	COG1737	Transcriptional regulator
S101359_RS04345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101359_RS04345	COG1263	PTS System
S101359_RS04350	COG5434	Belongs to the glycosyl hydrolase 28 family
S101359_RS04355	COG1132	(ABC) transporter
S101359_RS04360	COG1132	(ABC) transporter
S101359_RS04365	COG2259	Doxx family
S101359_RS04370	COG2514	catechol 2,3-dioxygenase activity
S101359_RS04375	COG0673	inositol 2-dehydrogenase activity
S101359_RS04380	COG4585	Histidine kinase
S101359_RS04385	COG2197	response regulator
S101359_RS04390	COG1131	(ABC) transporter
S101359_RS04395	COG0842	Transport permease protein
S101359_RS04395	COG1511	domain protein
S101359_RS04400	COG0842	Transport permease protein
S101359_RS04405	COG1695	Transcriptional regulator
S101359_RS04410	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
S101359_RS04415	COG2732	(Barnase) inhibitor
S101359_RS04420	COG0604	alcohol dehydrogenase
S101359_RS04425	COG2318	DinB family
S101359_RS04430	COG2814	Major facilitator Superfamily
S101359_RS04435	COG1846	Transcriptional regulator
S101359_RS04440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S101359_RS04440	COG0392	lysyltransferase activity
S101359_RS04445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101359_RS04450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS04455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS04460	COG0384	phenazine biosynthesis protein PhzF
S101359_RS04465	COG0778	Nitroreductase
S101359_RS04480	COG1090	epimerase
S101359_RS04485	COG2137	regulation of response to DNA damage stimulus
S101359_RS04495	COG2814	Major facilitator Superfamily
S101359_RS04510	COG3103	Sh3 type 3 domain protein
S101359_RS04515	COG5658	integral membrane protein
S101359_RS04520	COG0596	Alpha beta hydrolase
S101359_RS04525	COG0463	Glycosyl transferase, family 2
S101359_RS04530	COG4485	Bacterial membrane protein, YfhO
S101359_RS04535	COG1988	membrane-bound metal-dependent
S101359_RS04540	COG1194	a g-specific adenine glycosylase
S101359_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS04565	COG3557	Belongs to the UPF0374 family
S101359_RS04570	COG1132	(ABC) transporter
S101359_RS04575	COG4129	membrane
S101359_RS04580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S101359_RS04585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S101359_RS04590	COG0735	belongs to the Fur family
S101359_RS04710	COG1063	alcohol dehydrogenase
S101359_RS04725	COG4326	sporulation control protein
S101359_RS04730	COG3340	Belongs to the peptidase S51 family
S101359_RS04735	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S101359_RS04745	COG0753	catalase activity
S101359_RS04750	COG1116	anion transmembrane transporter activity
S101359_RS04755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101359_RS04760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101359_RS04770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S101359_RS04780	COG1476	TRANSCRIPTIONal
S101359_RS04790	COG3382	B3 4 domain protein
S101359_RS04795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S101359_RS04805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S101359_RS04810	COG0789	Transcriptional regulator
S101359_RS04815	COG1664	Polymer-forming cytoskeletal
S101359_RS04820	COG1664	Polymer-forming cytoskeletal
S101359_RS04825	COG2766	serine protein kinase
S101359_RS04830	COG2718	Belongs to the UPF0229 family
S101359_RS04835	COG1846	Transcriptional regulator
S101359_RS04840	COG1566	PFAM secretion protein HlyD family protein
S101359_RS04845	COG2814	Major facilitator Superfamily
S101359_RS04850	COG0655	NAD(P)H dehydrogenase (quinone) activity
S101359_RS04865	COG1725	Transcriptional regulator
S101359_RS04870	COG1131	(ABC) transporter
S101359_RS04875	COG1131	(ABC) transporter
S101359_RS04880	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101359_RS04885	COG1278	Cold shock
S101359_RS04895	COG1464	Belongs to the NlpA lipoprotein family
S101359_RS04900	COG3706	GGDEF domain
S101359_RS04905	COG1823	symporter activity
S101359_RS04925	COG5577	PFAM Coat F domain
S101359_RS04935	COG0737	Belongs to the 5'-nucleotidase family
S101359_RS04935	COG1525	nuclease
S101359_RS04935	COG4085	toxin activity
S101359_RS04940	COG3764	Sortase (surface protein transpeptidase)
S101359_RS04945	COG0564	pseudouridine synthase activity
S101359_RS04955	COG0517	IMP dehydrogenase activity
S101359_RS04960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S101359_RS04965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S101359_RS04965	COG3153	acetyltransferase
S101359_RS04975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101359_RS04980	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
S101359_RS04985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S101359_RS04990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S101359_RS04995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S101359_RS05000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S101359_RS05005	COG2203	Gaf domain
S101359_RS05005	COG4585	Histidine kinase
S101359_RS05010	COG2197	response regulator
S101359_RS05015	COG0431	NADPH-dependent FMN reductase
S101359_RS05030	COG1388	LysM domain
S101359_RS05030	COG0791	NLP P60 protein
S101359_RS05035	COG1959	2 iron, 2 sulfur cluster binding
S101359_RS05040	COG0668	transmembrane transport
S101359_RS05045	COG2719	SpoVR family
S101359_RS05050	COG1785	Belongs to the alkaline phosphatase family
S101359_RS05055	COG1388	LysM domain
S101359_RS05055	COG0791	NLP P60 protein
S101359_RS05060	COG0583	DNA-binding transcription factor activity
S101359_RS05065	COG0372	Belongs to the citrate synthase family
S101359_RS05070	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS05075	COG0531	amino acid
S101359_RS05080	COG0733	neurotransmitter:sodium symporter activity
S101359_RS05095	COG0456	acetyltransferase
S101359_RS05100	COG0833	amino acid
S101359_RS05105	COG4187	Peptidase family M20/M25/M40
S101359_RS05110	COG1012	belongs to the aldehyde dehydrogenase family
S101359_RS05115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101359_RS05130	COG1595	DNA-templated transcription, initiation
S101359_RS05135	COG0667	Aldo Keto reductase
S101359_RS05140	COG0204	Acyl-transferase
S101359_RS05145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101359_RS05150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101359_RS05155	COG1253	flavin adenine dinucleotide binding
S101359_RS05160	COG0789	Transcriptional regulator
S101359_RS05170	COG1253	flavin adenine dinucleotide binding
S101359_RS05175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S101359_RS05180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S101359_RS05185	COG0584	glycerophosphoryl diester phosphodiesterase
S101359_RS05195	COG0668	transmembrane transport
S101359_RS05200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S101359_RS05205	COG0726	polysaccharide deacetylase
S101359_RS05210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101359_RS05215	COG1757	Na H antiporter
S101359_RS05220	COG0589	response to stress
S101359_RS05225	COG1132	(ABC) transporter
S101359_RS05230	COG1132	(ABC) transporter
S101359_RS05235	COG0702	epimerase
S101359_RS05255	COG0189	ligase activity
S101359_RS05260	COG0189	ligase activity
S101359_RS05270	COG4399	Belongs to the UPF0754 family
S101359_RS05280	COG4335	DNA alkylation repair
S101359_RS05285	COG0561	phosphatase activity
S101359_RS05290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S101359_RS05300	COG0475	glutathione-regulated potassium exporter activity
S101359_RS05305	COG0490	domain, Protein
S101359_RS05315	COG1024	Enoyl-CoA hydratase
S101359_RS05325	COG4152	abc transporter atp-binding protein
S101359_RS05330	COG1668	transmembrane transport
S101359_RS05335	COG0420	3'-5' exonuclease activity
S101359_RS05340	COG4717	serine-type aminopeptidase activity
S101359_RS05345	COG3481	metal-dependent phosphohydrolase, HD sub domain
S101359_RS05355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S101359_RS05395	COG4980	gas vesicle protein
S101359_RS05410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S101359_RS05415	COG0537	adenosine 5'-monophosphoramidase activity
S101359_RS05420	COG1131	(ABC) transporter
S101359_RS05425	COG4473	ABC transporter
S101359_RS05435	COG1473	amidohydrolase
S101359_RS05440	COG3069	C4-dicarboxylate transmembrane transporter activity
S101359_RS05445	COG2329	Antibiotic biosynthesis monooxygenase
S101359_RS05450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101359_RS05455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S101359_RS05460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S101359_RS05465	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
S101359_RS05470	COG1309	transcriptional regulator
S101359_RS05475	COG1511	domain protein
S101359_RS05480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101359_RS05490	COG1363	Peptidase, m42
S101359_RS05495	COG1301	dicarboxylic acid transport
S101359_RS05505	COG1234	tRNA 3'-trailer cleavage
S101359_RS05510	COG0095	Lipoate-protein ligase
S101359_RS05515	COG0702	epimerase
S101359_RS05520	COG0318	PFAM AMP-dependent synthetase and ligase
S101359_RS05530	COG0501	Belongs to the peptidase M48B family
S101359_RS05535	COG1404	Belongs to the peptidase S8 family
S101359_RS05540	COG0456	acetyltransferase
S101359_RS05545	COG0604	alcohol dehydrogenase
S101359_RS05550	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S101359_RS05555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS05560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS05565	COG0406	alpha-ribazole phosphatase activity
S101359_RS05570	COG0183	Belongs to the thiolase family
S101359_RS05575	COG1960	acyl-CoA dehydrogenase activity
S101359_RS05580	COG2084	Dehydrogenase
S101359_RS05585	COG1012	belongs to the aldehyde dehydrogenase family
S101359_RS05590	COG1024	Enoyl-CoA hydratase
S101359_RS05600	COG0840	transmembrane signaling receptor activity
S101359_RS05605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101359_RS05605	COG0723	plastoquinol--plastocyanin reductase activity
S101359_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS05620	COG4903	ComK protein
S101359_RS05630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101359_RS05645	COG0398	Pfam SNARE associated Golgi protein
S101359_RS05650	COG0681	Belongs to the peptidase S26 family
S101359_RS05655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S101359_RS05660	COG1846	Transcriptional regulator
S101359_RS05665	COG3180	Ammonia monooxygenase
S101359_RS05675	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S101359_RS05680	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S101359_RS05685	COG1074	ATP-dependent DNA helicase activity
S101359_RS05690	COG0420	3'-5' exonuclease activity
S101359_RS05695	COG0419	ATPase involved in DNA repair
S101359_RS05700	COG1403	HNH endonuclease
S101359_RS05735	COG2311	Membrane
S101359_RS05745	COG5337	Spore coat protein CotH
S101359_RS05750	COG0179	Fumarylacetoacetate (FAA) hydrolase
S101359_RS05760	COG1404	Belongs to the peptidase S8 family
S101359_RS05770	COG0367	asparagine synthase
S101359_RS05775	COG1562	ergosterol biosynthetic process
S101359_RS05780	COG0534	Mate efflux family protein
S101359_RS05785	COG1917	Cupin 2, conserved barrel domain protein
S101359_RS05785	COG2207	Transcriptional regulator
S101359_RS05790	COG0109	protoheme IX farnesyltransferase activity
S101359_RS05795	COG1609	Transcriptional regulator
S101359_RS05800	COG0673	inositol 2-dehydrogenase activity
S101359_RS05805	COG2318	DinB family
S101359_RS05810	COG1279	arginine transmembrane transporter activity
S101359_RS05820	COG1357	PFAM Pentapeptide repeats (8 copies)
S101359_RS05825	COG2267	carboxylic ester hydrolase activity
S101359_RS05830	COG0529	Catalyzes the synthesis of activated sulfate
S101359_RS05835	COG2046	Belongs to the sulfate adenylyltransferase family
S101359_RS05840	COG0175	sulfate reduction
S101359_RS05845	COG2045	Belongs to the ComB family
S101359_RS05850	COG1809	phosphosulfolactate synthase activity
S101359_RS05855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101359_RS05860	COG4948	Mandelate Racemase Muconate Lactonizing
S101359_RS05865	COG2814	Major facilitator Superfamily
S101359_RS05875	COG2153	protein acetylation
S101359_RS05880	COG0646	methionine synthase
S101359_RS05880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S101359_RS05890	COG2996	Protein conserved in bacteria
S101359_RS05905	COG1307	EDD domain protein, DegV family
S101359_RS05910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101359_RS05925	COG0561	phosphatase activity
S101359_RS05930	COG1073	alpha beta
S101359_RS05935	COG2151	metal-sulfur cluster biosynthetic enzyme
S101359_RS05945	COG0277	FAD linked oxidase domain protein
S101359_RS05950	COG2271	Major facilitator Superfamily
S101359_RS05955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S101359_RS05960	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S101359_RS05970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S101359_RS05975	COG0505	Belongs to the CarA family
S101359_RS05980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S101359_RS05985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S101359_RS06000	COG2267	carboxylic ester hydrolase activity
S101359_RS06010	COG1744	ABC transporter substrate-binding protein PnrA-like
S101359_RS06025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101359_RS06030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S101359_RS06035	COG5504	Zn-dependent protease
S101359_RS06040	COG0444	Belongs to the ABC transporter superfamily
S101359_RS06045	COG4608	Belongs to the ABC transporter superfamily
S101359_RS06055	COG0601	transmembrane transport
S101359_RS06060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101359_RS06070	COG0180	Tryptophanyl-tRNA synthetase
S101359_RS06075	COG4166	transmembrane transport
S101359_RS06080	COG0601	transmembrane transport
S101359_RS06085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101359_RS06090	COG0444	Belongs to the ABC transporter superfamily
S101359_RS06095	COG4608	Belongs to the ABC transporter superfamily
S101359_RS06110	COG0456	acetyltransferase
S101359_RS06115	COG1393	Belongs to the ArsC family
S101359_RS06120	COG0861	Integral membrane protein TerC family
S101359_RS06125	COG4862	establishment of competence for transformation
S101359_RS06130	COG4469	Competence protein
S101359_RS06135	COG1164	Oligoendopeptidase f
S101359_RS06150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S101359_RS06155	COG2346	COG2346, Truncated hemoglobins
S101359_RS06160	COG0741	lytic transglycosylase activity
S101359_RS06165	COG4116	CYTH
S101359_RS06175	COG2357	RelA SpoT domain protein
S101359_RS06180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S101359_RS06185	COG0564	pseudouridine synthase activity
S101359_RS06200	COG0475	glutathione-regulated potassium exporter activity
S101359_RS06200	COG0569	domain protein
S101359_RS06205	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S101359_RS06210	COG0352	thiamine-phosphate diphosphorylase activity
S101359_RS06215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101359_RS06220	COG2104	thiamine diphosphate biosynthetic process
S101359_RS06225	COG2022	thiamine diphosphate biosynthetic process
S101359_RS06230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S101359_RS06235	COG0351	phosphomethylpyrimidine kinase
S101359_RS06240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S101359_RS06295	COG0210	DNA helicase
S101359_RS06320	COG2153	protein acetylation
S101359_RS06330	COG2382	esterase
S101359_RS06335	COG0626	cystathionine gamma-synthase activity
S101359_RS06340	COG0626	cystathionine gamma-synthase activity
S101359_RS06350	COG5505	Protein of unknown function (DUF819)
S101359_RS06360	COG0457	Tetratricopeptide repeat
S101359_RS06370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S101359_RS06415	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S101359_RS06445	COG3209	COG3209 Rhs family protein
S101359_RS06450	COG1285	pathogenesis
S101359_RS06470	COG0726	polysaccharide deacetylase
S101359_RS06490	COG3383	formate dehydrogenase (NAD+) activity
S101359_RS06495	COG2427	Protein of unknown function (DUF1641)
S101359_RS06505	COG1051	belongs to the nudix hydrolase family
S101359_RS06515	COG2124	cytochrome p450
S101359_RS06520	COG1819	glycosyl
S101359_RS06540	COG1587	Uroporphyrinogen-III synthase
S101359_RS06545	COG0390	transport system, permease component
S101359_RS06550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101359_RS06555	COG0697	spore germination
S101359_RS06560	COG4297	protein containing double-stranded beta helix domain
S101359_RS06570	COG1252	NADH dehydrogenase
S101359_RS06575	COG1904	glucuronate isomerase
S101359_RS06580	COG2211	Major facilitator Superfamily
S101359_RS06585	COG1609	Transcriptional regulator
S101359_RS06590	COG0246	Mannitol dehydrogenase
S101359_RS06595	COG2721	sulfolactate sulfo-lyase activity
S101359_RS06600	COG0730	response to heat
S101359_RS06605	COG2318	DinB family
S101359_RS06610	COG0457	Tetratricopeptide repeat
S101359_RS06625	COG3409	Peptidoglycan-binding domain 1 protein
S101359_RS06625	COG1388	LysM domain
S101359_RS06625	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101359_RS06635	COG4195	phage-related replication protein
S101359_RS06640	COG2856	Zn peptidase
S101359_RS06645	COG1396	sequence-specific DNA binding
S101359_RS06655	COG1522	sequence-specific DNA binding
S101359_RS06660	COG1484	DNA-dependent DNA replication
S101359_RS06680	COG1595	DNA-templated transcription, initiation
S101359_RS06685	COG5484	DNA packaging
S101359_RS06685	COG3728	DNA packaging
S101359_RS06690	COG1783	phage Terminase large subunit
S101359_RS06695	COG5518	Phage portal protein
S101359_RS06700	COG0338	D12 class N6 adenine-specific DNA methyltransferase
S101359_RS06705	COG4653	Phage capsid family
S101359_RS06755	COG3953	SLT domain
S101359_RS06755	COG5412	phage tail tape measure protein
S101359_RS06760	COG1652	LysM domain
S101359_RS06765	COG4193	domain, Protein
S101359_RS06780	COG3628	GPW Gp25 family protein
S101359_RS06785	COG3299	homolog of phage Mu protein gp47
S101359_RS06790	COG3778	Protein conserved in bacteria
S101359_RS06830	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101359_RS06830	COG3409	Peptidoglycan-binding domain 1 protein
S101359_RS06845	COG0306	phosphate transporter
S101359_RS06850	COG1392	Phosphate transport regulator
S101359_RS06855	COG0531	amino acid
S101359_RS06860	COG0346	lactoylglutathione lyase activity
S101359_RS06865	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S101359_RS06870	COG0463	Glycosyl transferase, family 2
S101359_RS06880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101359_RS06885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101359_RS06890	COG2362	D-Aminopeptidase
S101359_RS06895	COG0601	transmembrane transport
S101359_RS06900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101359_RS06905	COG0444	Belongs to the ABC transporter superfamily
S101359_RS06910	COG4166	transmembrane transport
S101359_RS06915	COG1619	proteins homologs of microcin C7 resistance protein MccF
S101359_RS06920	COG4948	Mandelate Racemase Muconate Lactonizing
S101359_RS06925	COG0791	NLP P60 protein
S101359_RS06930	COG4608	Belongs to the ABC transporter superfamily
S101359_RS06935	COG2706	6-phosphogluconolactonase activity
S101359_RS06940	COG1834	amidinotransferase
S101359_RS06945	COG1607	acyl-coa hydrolase
S101359_RS06950	COG2323	membrane
S101359_RS06955	COG1695	Transcriptional regulator
S101359_RS06970	COG2318	DinB family
S101359_RS06975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101359_RS06980	COG2076	Multidrug Resistance protein
S101359_RS06985	COG2076	Multidrug Resistance protein
S101359_RS06990	COG0788	formyltetrahydrofolate deformylase activity
S101359_RS06995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S101359_RS07000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S101359_RS07005	COG1764	response to oxidative stress
S101359_RS07010	COG1846	Transcriptional regulator
S101359_RS07015	COG1764	response to oxidative stress
S101359_RS07030	COG0457	Tetratricopeptide repeat
S101359_RS07030	COG0463	Glycosyl transferase, family 2
S101359_RS07040	COG0590	tRNA wobble adenosine to inosine editing
S101359_RS07050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101359_RS07055	COG1404	Belongs to the peptidase S8 family
S101359_RS07060	COG1366	Belongs to the anti-sigma-factor antagonist family
S101359_RS07065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S101359_RS07070	COG1122	ATPase activity
S101359_RS07075	COG4721	ABC-type cobalt transport system, permease component
S101359_RS07085	COG0745	RESPONSE REGULATOR receiver
S101359_RS07090	COG5002	protein histidine kinase activity
S101359_RS07090	COG3850	Histidine kinase
S101359_RS07095	COG3212	peptidase
S101359_RS07100	COG3212	peptidase
S101359_RS07110	COG2239	Acts as a magnesium transporter
S101359_RS07115	COG0789	Transcriptional regulator
S101359_RS07130	COG1846	Transcriptional regulator
S101359_RS07135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101359_RS07140	COG0726	polysaccharide deacetylase
S101359_RS07145	COG1408	metallophosphoesterase
S101359_RS07160	COG0463	Glycosyl transferase, family 2
S101359_RS07165	COG3285	dna ligase
S101359_RS07165	COG1793	dna ligase
S101359_RS07170	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S101359_RS07185	COG3300	MHYT domain
S101359_RS07185	COG5001	Diguanylate cyclase
S101359_RS07190	COG0586	Pfam SNARE associated Golgi protein
S101359_RS07200	COG0861	Integral membrane protein TerC family
S101359_RS07205	COG1191	sigma factor activity
S101359_RS07225	COG0501	Belongs to the peptidase M48B family
S101359_RS07230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S101359_RS07235	COG2323	membrane
S101359_RS07250	COG3594	Acyltransferase
S101359_RS07255	COG5002	protein histidine kinase activity
S101359_RS07260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S101359_RS07270	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
S101359_RS07275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S101359_RS07280	COG0436	Aminotransferase
S101359_RS07285	COG1850	ribulose-bisphosphate carboxylase activity
S101359_RS07295	COG0235	Class ii aldolase
S101359_RS07300	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S101359_RS07305	COG3339	Conserved Protein
S101359_RS07320	COG3852	Histidine kinase
S101359_RS07325	COG1846	Transcriptional regulator
S101359_RS07330	COG1360	Flagellar Motor Protein
S101359_RS07335	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S101359_RS07340	COG0542	response to heat
S101359_RS07345	COG3949	Membrane
S101359_RS07360	COG0720	synthase
S101359_RS07365	COG0602	queuosine metabolic process
S101359_RS07370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S101359_RS07375	COG1366	Belongs to the anti-sigma-factor antagonist family
S101359_RS07385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101359_RS07390	COG4873	Protein conserved in bacteria
S101359_RS07400	COG3773	Cell wall hydrolase
S101359_RS07405	COG2244	polysaccharide biosynthetic process
S101359_RS07410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101359_RS07415	COG2217	Heavy metal translocating P-type atpase
S101359_RS07425	COG0006	proline dipeptidase activity
S101359_RS07430	COG1609	Transcriptional regulator
S101359_RS07435	COG3711	transcriptional antiterminator
S101359_RS07440	COG2190	(PTS) system
S101359_RS07440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101359_RS07440	COG1263	PTS System
S101359_RS07445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101359_RS07450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S101359_RS07460	COG1533	DNA photolyase activity
S101359_RS07465	COG0456	acetyltransferase
S101359_RS07470	COG0840	transmembrane signaling receptor activity
S101359_RS07475	COG2084	Dehydrogenase
S101359_RS07480	COG2340	Cysteine-rich secretory protein family
S101359_RS07485	COG0768	penicillin binding
S101359_RS07490	COG4191	Histidine kinase
S101359_RS07495	COG0436	Aminotransferase
S101359_RS07505	COG0835	chemotaxis
S101359_RS07505	COG0784	Response regulator, receiver
S101359_RS07515	COG2814	Major facilitator Superfamily
S101359_RS07520	COG1376	ErfK ybiS ycfS ynhG family protein
S101359_RS07525	COG1408	metallophosphoesterase
S101359_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS07535	COG2200	EAL domain
S101359_RS07540	COG3546	catalase activity
S101359_RS07545	COG4703	Protein of unknown function (DUF1797)
S101359_RS07550	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
S101359_RS07560	COG0517	IMP dehydrogenase activity
S101359_RS07565	COG0583	DNA-binding transcription factor activity
S101359_RS07570	COG0716	FMN binding
S101359_RS07580	COG0716	FMN binding
S101359_RS07585	COG2171	N-acyltransferase activity
S101359_RS07590	COG1473	amidohydrolase
S101359_RS07600	COG0668	transmembrane transport
S101359_RS07605	COG0450	alkyl hydroperoxide reductase
S101359_RS07610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101359_RS07625	COG0746	molybdenum cofactor guanylyltransferase activity
S101359_RS07630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S101359_RS07635	COG0303	'Molybdopterin
S101359_RS07640	COG1763	Mo-molybdopterin cofactor biosynthetic process
S101359_RS07645	COG0314	molybdopterin synthase activity
S101359_RS07650	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S101359_RS07655	COG1132	(ABC) transporter
S101359_RS07660	COG1132	(ABC) transporter
S101359_RS07670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101359_RS07675	COG1136	(ABC) transporter
S101359_RS07680	COG0577	efflux transmembrane transporter activity
S101359_RS07685	COG1349	DNA-binding transcription factor activity
S101359_RS07690	COG1105	Belongs to the carbohydrate kinase PfkB family
S101359_RS07695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101359_RS07695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101359_RS07695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101359_RS07700	COG0681	Belongs to the peptidase S26 family
S101359_RS07710	COG0488	(ABC) transporter
S101359_RS07715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S101359_RS07720	COG2309	aminopeptidase activity
S101359_RS07730	COG1077	Cell shape determining protein MreB Mrl
S101359_RS07735	COG2002	toxin-antitoxin pair type II binding
S101359_RS07745	COG2105	PFAM AIG2 family protein
S101359_RS07745	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
S101359_RS07750	COG0569	domain protein
S101359_RS07755	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S101359_RS07760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S101359_RS07770	COG0561	phosphatase activity
S101359_RS07775	COG0242	peptide deformylase activity
S101359_RS07785	COG0497	DNA recombination
S101359_RS07790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101359_RS07795	COG0022	dehydrogenase e1 component
S101359_RS07800	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101359_RS07805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101359_RS07810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101359_RS07825	COG1982	Orn Lys Arg decarboxylase major
S101359_RS07830	COG4476	Belongs to the UPF0223 family
S101359_RS07835	COG4493	Belongs to the UPF0637 family
S101359_RS07845	COG0483	inositol monophosphate 1-phosphatase activity
S101359_RS07880	COG1217	gtp-binding protein TYPA
S101359_RS07890	COG4896	Protein conserved in bacteria
S101359_RS07900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S101359_RS07905	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S101359_RS07910	COG2066	Belongs to the glutaminase family
S101359_RS07915	COG4838	Belongs to the UPF0358 family
S101359_RS07920	COG0772	Belongs to the SEDS family
S101359_RS07925	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S101359_RS07930	COG1612	heme a metabolic process
S101359_RS07940	COG2010	Cytochrome c
S101359_RS07940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S101359_RS07945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S101359_RS07950	COG1845	cytochrome c oxidase, subunit III
S101359_RS07955	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S101359_RS07960	COG3336	cytochrome c oxidase
S101359_RS07970	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S101359_RS07975	COG2340	Cysteine-rich secretory protein family
S101359_RS07995	COG3679	Belongs to the UPF0342 family
S101359_RS08000	COG4471	UPF0298 protein
S101359_RS08005	COG0742	ribosomal rna small subunit methyltransferase
S101359_RS08010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S101359_RS08015	COG3314	Sporulation integral membrane protein YlbJ
S101359_RS08020	COG1752	Esterase of the alpha-beta hydrolase superfamily
S101359_RS08025	COG3480	Lon protease (S16) C-terminal proteolytic domain
S101359_RS08030	COG1323	Belongs to the UPF0348 family
S101359_RS08040	COG1399	metal-binding, possibly nucleic acid-binding protein
S101359_RS08060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S101359_RS08065	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
S101359_RS08070	COG2001	Belongs to the MraZ family
S101359_RS08075	COG0275	rRNA processing
S101359_RS08080	COG4839	cell division protein FtsL
S101359_RS08085	COG0768	penicillin binding
S101359_RS08090	COG0768	penicillin binding
S101359_RS08095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S101359_RS08100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101359_RS08105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S101359_RS08110	COG0772	Belongs to the SEDS family
S101359_RS08115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101359_RS08120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S101359_RS08125	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S101359_RS08130	COG3879	Bacterial protein of unknown function (DUF881)
S101359_RS08135	COG3879	Bacterial protein of unknown function (DUF881)
S101359_RS08140	COG3856	small basic protein
S101359_RS08145	COG0849	cell division
S101359_RS08150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S101359_RS08155	COG1404	Belongs to the peptidase S8 family
S101359_RS08155	COG4412	M6 family metalloprotease domain protein
S101359_RS08165	COG1191	sigma factor activity
S101359_RS08170	COG1191	sigma factor activity
S101359_RS08175	COG1119	ATPase activity
S101359_RS08180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101359_RS08185	COG1873	PFAM PRC-barrel domain
S101359_RS08190	COG1496	oxidoreductase activity
S101359_RS08195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
S101359_RS08200	COG1799	cell septum assembly
S101359_RS08205	COG0762	integral membrane protein
S101359_RS08210	COG2302	S4 RNA-binding domain
S101359_RS08215	COG3599	regulation of cell shape
S101359_RS08225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S101359_RS08230	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101359_RS08235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S101359_RS08240	COG0564	pseudouridine synthase activity
S101359_RS08250	COG2233	PERMEase
S101359_RS08255	COG0540	Belongs to the ATCase OTCase family
S101359_RS08260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S101359_RS08265	COG0505	Belongs to the CarA family
S101359_RS08270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S101359_RS08275	COG0543	2 iron, 2 sulfur cluster binding
S101359_RS08280	COG0167	dihydroorotate dehydrogenase activity
S101359_RS08285	COG0284	orotidine-5'-phosphate decarboxylase activity
S101359_RS08290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S101359_RS08295	COG0175	sulfate reduction
S101359_RS08300	COG0306	phosphate transporter
S101359_RS08305	COG2046	Belongs to the sulfate adenylyltransferase family
S101359_RS08310	COG0529	Catalyzes the synthesis of activated sulfate
S101359_RS08315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S101359_RS08320	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
S101359_RS08325	COG1648	precorrin-2 dehydrogenase activity
S101359_RS08330	COG1293	RNA-binding protein homologous to eukaryotic snRNP
S101359_RS08335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S101359_RS08340	COG1561	YicC-like family, N-terminal region
S101359_RS08350	COG0194	GDP metabolic process
S101359_RS08355	COG1758	RNA polymerase activity
S101359_RS08360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S101359_RS08365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S101359_RS08370	COG0242	peptide deformylase activity
S101359_RS08375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S101359_RS08380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S101359_RS08380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101359_RS08390	COG0631	protein serine/threonine phosphatase activity
S101359_RS08395	COG2815	serine threonine protein kinase
S101359_RS08395	COG0515	serine threonine protein kinase
S101359_RS08400	COG1162	GTPase activity
S101359_RS08405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S101359_RS08410	COG1564	THIamine pyrophosphokinase
S101359_RS08420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S101359_RS08425	COG1302	Protein conserved in bacteria
S101359_RS08430	COG1461	Dihydroxyacetone kinase
S101359_RS08435	COG1760	l-serine dehydratase
S101359_RS08440	COG1760	l-serine dehydratase
S101359_RS08445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S101359_RS08450	COG1349	DNA-binding transcription factor activity
S101359_RS08450	COG2050	protein possibly involved in aromatic compounds catabolism
S101359_RS08460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S101359_RS08465	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS08475	COG0571	ribonuclease III activity
S101359_RS08480	COG1196	nuclear chromosome segregation
S101359_RS08485	COG0552	protein localization to endoplasmic reticulum
S101359_RS08490	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S101359_RS08495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S101359_RS08500	COG0228	four-way junction DNA binding
S101359_RS08505	COG1837	Belongs to the UPF0109 family
S101359_RS08515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S101359_RS08530	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S101359_RS08535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S101359_RS08545	COG2257	FlhB HrpN YscU SpaS Family
S101359_RS08555	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S101359_RS08560	COG0758	DNA mediated transformation
S101359_RS08565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S101359_RS08570	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S101359_RS08575	COG4974	Belongs to the 'phage' integrase family
S101359_RS08580	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S101359_RS08585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S101359_RS08595	COG1815	bacterial-type flagellum-dependent cell motility
S101359_RS08600	COG1558	bacterial-type flagellum-dependent cell motility
S101359_RS08605	COG1677	Flagellar hook-basal body complex protein FliE
S101359_RS08610	COG1766	The M ring may be actively involved in energy transduction
S101359_RS08615	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101359_RS08620	COG1317	bacterial-type flagellum organization
S101359_RS08625	COG1157	protein secretion by the type III secretion system
S101359_RS08630	COG2882	bacterial-type flagellum organization
S101359_RS08635	COG3334	PFAM MgtE intracellular
S101359_RS08640	COG3144	bacterial-type flagellum assembly
S101359_RS08645	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S101359_RS08650	COG4786	Flagellar basal body rod
S101359_RS08655	COG1582	Flagellar protein (FlbD)
S101359_RS08660	COG1580	Controls the rotational direction of flagella during chemotaxis
S101359_RS08665	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101359_RS08670	COG1776	CheC inhibitor of MCP methylation
S101359_RS08670	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101359_RS08675	COG2201	protein-glutamate methylesterase activity
S101359_RS08680	COG3190	flagellar
S101359_RS08685	COG1338	Plays a role in the flagellum-specific transport system
S101359_RS08690	COG1987	bacterial-type flagellum assembly
S101359_RS08695	COG1684	flagellar biosynthetic protein fliR
S101359_RS08700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S101359_RS08705	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S101359_RS08710	COG1419	protein localization to endoplasmic reticulum
S101359_RS08715	COG0455	bacterial-type flagellum organization
S101359_RS08720	COG2201	protein-glutamate methylesterase activity
S101359_RS08725	COG0643	Histidine kinase
S101359_RS08725	COG2198	Histidine kinase
S101359_RS08730	COG0835	chemotaxis
S101359_RS08735	COG1776	CheC inhibitor of MCP methylation
S101359_RS08740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
S101359_RS08745	COG1191	sigma factor activity
S101359_RS08760	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S101359_RS08765	COG0528	UMP kinase activity
S101359_RS08770	COG0233	cytoplasmic translational termination
S101359_RS08775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S101359_RS08780	COG4589	Belongs to the CDS family
S101359_RS08785	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S101359_RS08790	COG0750	zinc metalloprotease
S101359_RS08795	COG0442	prolyl-tRNA aminoacylation
S101359_RS08800	COG2176	DNA-directed DNA polymerase activity
S101359_RS08810	COG0779	Required for maturation of 30S ribosomal subunits
S101359_RS08815	COG0195	Participates in both transcription termination and antitermination
S101359_RS08820	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S101359_RS08825	COG1358	cellular component organization or biogenesis
S101359_RS08830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S101359_RS08835	COG1550	Protein conserved in bacteria
S101359_RS08840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S101359_RS08845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S101359_RS08850	COG0196	riboflavin kinase activity
S101359_RS08860	COG1185	polyribonucleotide nucleotidyltransferase activity
S101359_RS08865	COG0726	polysaccharide deacetylase
S101359_RS08870	COG0612	Peptidase, M16
S101359_RS08875	COG1873	PFAM PRC-barrel domain
S101359_RS08880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101359_RS08885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S101359_RS08890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S101359_RS08895	COG0527	aspartate kinase activity
S101359_RS08905	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S101359_RS08910	COG0740	serine-type endopeptidase activity
S101359_RS08920	COG1674	ftsk spoiiie
S101359_RS08920	COG4980	gas vesicle protein
S101359_RS08925	COG2188	Transcriptional regulator
S101359_RS08930	COG2814	Major facilitator Superfamily
S101359_RS08940	COG0612	Peptidase, M16
S101359_RS08945	COG0612	Peptidase, M16
S101359_RS08950	COG0300	oxidoreductase activity
S101359_RS08965	COG1426	Protein conserved in bacteria
S101359_RS08970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S101359_RS08975	COG1546	Belongs to the CinA family
S101359_RS08975	COG1058	Belongs to the CinA family
S101359_RS08980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S101359_RS08985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101359_RS08995	COG1692	metallophosphoesterase
S101359_RS09000	COG2359	stage V sporulation protein S
S101359_RS09005	COG1063	alcohol dehydrogenase
S101359_RS09010	COG0156	8-amino-7-oxononanoate synthase activity
S101359_RS09025	COG4550	Control of competence regulator ComK, YlbF/YmcA
S101359_RS09035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S101359_RS09040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S101359_RS09055	COG3226	Transcriptional regulator
S101359_RS09060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101359_RS09065	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S101359_RS09070	COG3321	synthase
S101359_RS09075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S101359_RS09075	COG2070	2-Nitropropane dioxygenase
S101359_RS09080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101359_RS09085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S101359_RS09090	COG3425	synthase
S101359_RS09095	COG1024	Enoyl-CoA hydratase
S101359_RS09100	COG1024	Enoyl-CoA hydratase
S101359_RS09105	COG0318	PFAM AMP-dependent synthetase and ligase
S101359_RS09105	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS09105	COG0300	oxidoreductase activity
S101359_RS09105	COG3321	synthase
S101359_RS09105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS09110	COG3321	synthase
S101359_RS09110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101359_RS09110	COG0300	oxidoreductase activity
S101359_RS09110	COG4221	oxidoreductase activity
S101359_RS09115	COG3321	synthase
S101359_RS09115	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS09115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101359_RS09115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS09115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101359_RS09120	COG3321	synthase
S101359_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS09120	COG4221	oxidoreductase activity
S101359_RS09120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS09125	COG3321	synthase
S101359_RS09125	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
S101359_RS09125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S101359_RS09125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101359_RS09130	COG2124	cytochrome p450
S101359_RS09140	COG1404	Belongs to the peptidase S8 family
S101359_RS09150	COG4195	phage-related replication protein
S101359_RS09155	COG1764	response to oxidative stress
S101359_RS09165	COG2076	Multidrug Resistance protein
S101359_RS09185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S101359_RS09210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101359_RS09215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101359_RS09220	COG4112	unkown
S101359_RS09225	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101359_RS09230	COG0464	growth
S101359_RS09235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S101359_RS09240	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
S101359_RS09245	COG0789	Transcriptional regulator
S101359_RS09250	COG0174	glutamine synthetase
S101359_RS09325	COG0456	acetyltransferase
S101359_RS09340	COG4282	regulation of fungal-type cell wall biogenesis
S101359_RS09385	COG2273	Hydrolase Family 16
S101359_RS09410	COG3391	amine dehydrogenase activity
S101359_RS09445	COG0395	ABC-type sugar transport system, permease component
S101359_RS09450	COG1175	transmembrane transport
S101359_RS09460	COG1609	Transcriptional regulator
S101359_RS09465	COG1309	transcriptional regulator
S101359_RS09475	COG0509	glycine decarboxylation via glycine cleavage system
S101359_RS09485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101359_RS09495	COG3118	belongs to the thioredoxin family
S101359_RS09500	COG0492	ferredoxin-NADP+ reductase activity
S101359_RS09520	COG0477	Major facilitator Superfamily
S101359_RS09525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S101359_RS09530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101359_RS09545	COG0657	acetylesterase activity
S101359_RS09555	COG1011	Hydrolase
S101359_RS09560	COG0667	Aldo Keto reductase
S101359_RS09570	COG2318	DinB family
S101359_RS09575	COG2367	Beta-lactamase
S101359_RS09585	COG0582	viral genome integration into host DNA
S101359_RS09595	COG2720	vancomycin resistance protein
S101359_RS09600	COG5553	Cysteine dioxygenase type I
S101359_RS09610	COG3409	Peptidoglycan-binding domain 1 protein
S101359_RS09635	COG0456	acetyltransferase
S101359_RS09640	COG4978	Transcriptional regulator
S101359_RS09640	COG0789	Transcriptional regulator
S101359_RS09645	COG2030	dehydratase
S101359_RS09660	COG2135	peptidase activity
S101359_RS09675	COG0457	Tetratricopeptide repeat
S101359_RS09690	COG1131	(ABC) transporter
S101359_RS09735	COG4195	phage-related replication protein
S101359_RS09740	COG3619	membrane
S101359_RS09760	COG4195	phage-related replication protein
S101359_RS09785	COG5577	PFAM Coat F domain
S101359_RS09795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S101359_RS09800	COG1388	LysM domain
S101359_RS09805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S101359_RS09810	COG4224	UPF0291 protein
S101359_RS09815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S101359_RS09825	COG3763	UPF0154 protein
S101359_RS09835	COG0785	Cytochrome C biogenesis protein
S101359_RS09840	COG2201	protein-glutamate methylesterase activity
S101359_RS09845	COG4846	Membrane protein involved in cytochrome C biogenesis
S101359_RS09855	COG0071	Belongs to the small heat shock protein (HSP20) family
S101359_RS09870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S101359_RS09875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101359_RS09895	COG0824	Thioesterase
S101359_RS09905	COG4841	protein insertion into membrane
S101359_RS09910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S101359_RS09915	COG1832	CoA-binding protein
S101359_RS09920	COG0187	DNA topoisomerase II activity
S101359_RS09925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S101359_RS09935	COG1115	amino acid carrier protein
S101359_RS09950	COG2246	polysaccharide biosynthetic process
S101359_RS09955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S101359_RS09960	COG0586	Pfam SNARE associated Golgi protein
S101359_RS09965	COG2404	hydrolase activity, acting on ester bonds
S101359_RS09970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S101359_RS09975	COG1024	Enoyl-CoA hydratase
S101359_RS09980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S101359_RS09985	COG0511	ligase activity, forming carbon-carbon bonds
S101359_RS09990	COG0439	Biotin carboxylase
S101359_RS09995	COG0318	PFAM AMP-dependent synthetase and ligase
S101359_RS10000	COG1960	acyl-CoA dehydrogenase activity
S101359_RS10005	COG1649	PFAM Uncharacterised BCR, COG1649
S101359_RS10015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS10015	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
S101359_RS10020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS10025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS10030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS10035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS10040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S101359_RS10040	COG1017	nitric oxide dioxygenase activity
S101359_RS10045	COG2027	D-alanyl-D-alanine carboxypeptidase
S101359_RS10050	COG2017	converts alpha-aldose to the beta-anomer
S101359_RS10060	COG2207	Transcriptional regulator
S101359_RS10060	COG3708	Transcriptional regulator
S101359_RS10075	COG0582	viral genome integration into host DNA
S101359_RS10080	COG0166	Belongs to the GPI family
S101359_RS10085	COG0405	Gamma-glutamyltransferase
S101359_RS10095	COG0604	alcohol dehydrogenase
S101359_RS10100	COG0493	'glutamate synthase
S101359_RS10105	COG0067	glutamate synthase
S101359_RS10105	COG0069	glutamate synthase activity
S101359_RS10105	COG0070	glutamate synthase
S101359_RS10110	COG0583	DNA-binding transcription factor activity
S101359_RS10115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S101359_RS10150	COG0693	protein deglycase activity
S101359_RS10160	COG0300	oxidoreductase activity
S101359_RS10165	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S101359_RS10170	COG2318	DinB family
S101359_RS10175	COG2814	Major facilitator Superfamily
S101359_RS10180	COG1070	Carbohydrate kinase
S101359_RS10200	COG1396	sequence-specific DNA binding
S101359_RS10250	COG1279	arginine transmembrane transporter activity
S101359_RS10265	COG3655	Transcriptional regulator
S101359_RS10285	COG1793	dna ligase
S101359_RS10320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101359_RS10335	COG0457	Tetratricopeptide repeat
S101359_RS10370	COG5444	nuclease activity
S101359_RS10375	COG1136	(ABC) transporter
S101359_RS10405	COG4282	regulation of fungal-type cell wall biogenesis
S101359_RS10465	COG0582	viral genome integration into host DNA
S101359_RS10470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S101359_RS10475	COG0243	molybdopterin cofactor binding
S101359_RS10490	COG1309	transcriptional regulator
S101359_RS10495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101359_RS10500	COG2207	Transcriptional regulator
S101359_RS10500	COG0662	Cupin 2, conserved barrel domain protein
S101359_RS10505	COG1309	transcriptional regulator
S101359_RS10510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101359_RS10515	COG3708	Transcriptional regulator
S101359_RS10520	COG2378	regulation of single-species biofilm formation
S101359_RS10530	COG0640	Transcriptional regulator
S101359_RS10535	COG0741	lytic transglycosylase activity
S101359_RS10540	COG2322	membrane
S101359_RS10555	COG3239	Fatty acid desaturase
S101359_RS10560	COG4585	Histidine kinase
S101359_RS10565	COG2197	response regulator
S101359_RS10570	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101359_RS10575	COG1388	LysM domain
S101359_RS10575	COG3584	3D domain protein
S101359_RS10580	COG0514	ATP-dependent DNA helicase (RecQ)
S101359_RS10590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S101359_RS10595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101359_RS10610	COG1012	belongs to the aldehyde dehydrogenase family
S101359_RS10615	COG1657	PFAM Prenyltransferase squalene oxidase
S101359_RS10620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S101359_RS10625	COG0733	neurotransmitter:sodium symporter activity
S101359_RS10630	COG0385	Bile acid
S101359_RS10635	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101359_RS10640	COG0567	Dehydrogenase, E1 component
S101359_RS10645	COG4548	von Willebrand factor, type A
S101359_RS10650	COG0714	Associated with various cellular activities
S101359_RS10655	COG2032	superoxide dismutase activity
S101359_RS10660	COG1388	LysM domain
S101359_RS10660	COG0791	NLP P60 protein
S101359_RS10665	COG1819	glycosyl
S101359_RS10670	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S101359_RS10675	COG0534	Mate efflux family protein
S101359_RS10680	COG1366	Belongs to the anti-sigma-factor antagonist family
S101359_RS10685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101359_RS10690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101359_RS10700	COG2962	Rard protein
S101359_RS10715	COG2610	gluconate transmembrane transporter activity
S101359_RS10720	COG1942	4-Oxalocrotonate Tautomerase
S101359_RS10725	COG1733	regulation of RNA biosynthetic process
S101359_RS10730	COG0778	Nitroreductase
S101359_RS10735	COG0400	carboxylic ester hydrolase activity
S101359_RS10740	COG0346	lactoylglutathione lyase activity
S101359_RS10750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101359_RS10755	COG0793	Belongs to the peptidase S41A family
S101359_RS10755	COG3409	Peptidoglycan-binding domain 1 protein
S101359_RS10760	COG2226	methyltransferase
S101359_RS10770	COG1876	peptidase activity
S101359_RS10775	COG0813	purine-nucleoside phosphorylase activity
S101359_RS10790	COG0671	phosphoesterase, PA-phosphatase related
S101359_RS10820	COG1509	lysine 2,3-aminomutase activity
S101359_RS10825	COG0456	acetyltransferase
S101359_RS10830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101359_RS10835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S101359_RS10840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S101359_RS10845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101359_RS10855	COG0456	acetyltransferase
S101359_RS10860	COG0463	Glycosyl transferase, family 2
S101359_RS10875	COG4641	Protein conserved in bacteria
S101359_RS10880	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
S101359_RS10885	COG0582	viral genome integration into host DNA
S101359_RS10890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S101359_RS10905	COG0366	Alpha amylase catalytic
S101359_RS10910	COG3397	chitin binding
S101359_RS10920	COG3655	Transcriptional regulator
S101359_RS10925	COG3739	integral membrane protein
S101359_RS10930	COG5444	nuclease activity
S101359_RS10935	COG2207	Transcriptional regulator
S101359_RS10935	COG3708	Transcriptional regulator
S101359_RS10940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101359_RS10960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S101359_RS10965	COG1846	Transcriptional regulator
S101359_RS10970	COG0534	Mate efflux family protein
S101359_RS10980	COG4698	Protein conserved in bacteria
S101359_RS10985	COG2755	lipolytic protein G-D-S-L family
S101359_RS10990	COG1999	signal sequence binding
S101359_RS11000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S101359_RS11005	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S101359_RS11010	COG1272	protein, Hemolysin III
S101359_RS11015	COG0204	Acyl-transferase
S101359_RS11020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S101359_RS11030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S101359_RS11040	COG2521	methyltransferase
S101359_RS11040	COG2136	Putative SAM-dependent methyltransferase
S101359_RS11055	COG1413	lyase activity
S101359_RS11060	COG1418	mRNA catabolic process
S101359_RS11065	COG0386	Belongs to the glutathione peroxidase family
S101359_RS11070	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S101359_RS11075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101359_RS11080	COG1278	Cold shock
S101359_RS11100	COG0328	RNA-DNA hybrid ribonuclease activity
S101359_RS11105	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
S101359_RS11110	COG0328	RNA-DNA hybrid ribonuclease activity
S101359_RS11120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101359_RS11135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S101359_RS11140	COG1755	Isoprenylcysteine carboxyl methyltransferase
S101359_RS11145	COG3424	synthase
S101359_RS11150	COG2233	PERMEase
S101359_RS11155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101359_RS11160	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
S101359_RS11170	COG0800	Aldolase
S101359_RS11175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101359_RS11180	COG1609	Transcriptional regulator
S101359_RS11185	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
S101359_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS11195	COG1199	ATP-dependent helicase activity
S101359_RS11210	COG0116	Belongs to the methyltransferase superfamily
S101359_RS11235	COG3359	exonuclease
S101359_RS11240	COG1111	helicase
S101359_RS11240	COG1205	dead DEAH box helicase
S101359_RS11245	COG2190	(PTS) system
S101359_RS11250	COG0071	Belongs to the small heat shock protein (HSP20) family
S101359_RS11285	COG3331	DNA recombination
S101359_RS11290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101359_RS11290	COG4499	WXG100 protein secretion system (Wss), protein YukC
S101359_RS11300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S101359_RS11305	COG3935	DnaD domain protein
S101359_RS11310	COG0017	Asparaginyl-tRNA synthetase
S101359_RS11315	COG0436	Aminotransferase
S101359_RS11320	COG5353	protein conserved in bacteria
S101359_RS11330	COG1199	ATP-dependent helicase activity
S101359_RS11330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S101359_RS11335	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
S101359_RS11340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S101359_RS11345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S101359_RS11355	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
S101359_RS11355	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
S101359_RS11360	COG0617	tRNA 3'-terminal CCA addition
S101359_RS11365	COG0438	transferase activity, transferring glycosyl groups
S101359_RS11370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101359_RS11385	COG1694	Mazg nucleotide pyrophosphohydrolase
S101359_RS11390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101359_RS11395	COG2140	Oxalate decarboxylase
S101359_RS11405	COG4347	Protein of unknown function (DUF1405)
S101359_RS11410	COG2010	Cytochrome c
S101359_RS11410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101359_RS11415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101359_RS11420	COG0723	plastoquinol--plastocyanin reductase activity
S101359_RS11430	COG5582	Belongs to the UPF0302 family
S101359_RS11435	COG0457	Tetratricopeptide repeat
S101359_RS11440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S101359_RS11445	COG0287	Prephenate dehydrogenase
S101359_RS11450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S101359_RS11455	COG0159	tryptophan synthase activity
S101359_RS11475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S101359_RS11480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S101359_RS11485	COG4401	Chorismate mutase type I
S101359_RS11490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S101359_RS11500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S101359_RS11505	COG0105	UTP biosynthetic process
S101359_RS11510	COG0142	geranyltranstransferase activity
S101359_RS11520	COG0142	geranyltranstransferase activity
S101359_RS11530	COG0302	gtp cyclohydrolase
S101359_RS11535	COG0776	regulation of translation
S101359_RS11540	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S101359_RS11555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S101359_RS11560	COG1160	GTP binding
S101359_RS11585	COG1304	FMN binding
S101359_RS11590	COG0539	negative regulation of cytoplasmic translation
S101359_RS11595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S101359_RS11605	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
S101359_RS11610	COG2959	enzyme of heme biosynthesis
S101359_RS11615	COG3409	Peptidoglycan-binding domain 1 protein
S101359_RS11615	COG3773	Cell wall hydrolase
S101359_RS11620	COG2339	peptidase activity
S101359_RS11625	COG0492	ferredoxin-NADP+ reductase activity
S101359_RS11630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101359_RS11635	COG4862	establishment of competence for transformation
S101359_RS11640	COG1408	metallophosphoesterase
S101359_RS11650	COG1388	LysM domain
S101359_RS11655	COG1266	CAAX protease self-immunity
S101359_RS11660	COG0514	ATP-dependent DNA helicase (RecQ)
S101359_RS11665	COG4955	Helix-turn-helix domain
S101359_RS11670	COG1141	Ferredoxin
S101359_RS11675	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S101359_RS11680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S101359_RS11685	COG0710	3-dehydroquinate dehydratase activity
S101359_RS11695	COG1595	DNA-templated transcription, initiation
S101359_RS11700	COG5002	protein histidine kinase activity
S101359_RS11705	COG0745	RESPONSE REGULATOR receiver
S101359_RS11710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S101359_RS11715	COG1333	cytochrome c biogenesis protein
S101359_RS11720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101359_RS11725	COG1187	pseudouridine synthase activity
S101359_RS11730	COG0700	Nucleoside recognition
S101359_RS11735	COG2715	membrane protein required for spore maturation
S101359_RS11740	COG1686	Belongs to the peptidase S11 family
S101359_RS11750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S101359_RS11755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S101359_RS11765	COG1547	Domain of unknown function (DUF309)
S101359_RS11770	COG0456	acetyltransferase
S101359_RS11775	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S101359_RS11780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S101359_RS11780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S101359_RS11785	COG0307	riboflavin synthase, alpha
S101359_RS11790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S101359_RS11790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S101359_RS11800	COG0681	Belongs to the peptidase S26 family
S101359_RS11805	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
S101359_RS11810	COG1278	Cold shock
S101359_RS11820	COG0673	inositol 2-dehydrogenase activity
S101359_RS11845	COG2182	Extracellular solute-binding protein
S101359_RS11850	COG1175	transmembrane transport
S101359_RS11855	COG3833	ABC-type maltose transport systems, permease component
S101359_RS11870	COG3420	alginic acid biosynthetic process
S101359_RS11880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S101359_RS11885	COG4086	secreted protein
S101359_RS11890	COG0019	diaminopimelate decarboxylase activity
S101359_RS11895	COG0697	spore germination
S101359_RS11910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101359_RS11930	COG1191	sigma factor activity
S101359_RS11935	COG2172	sigma factor antagonist activity
S101359_RS11940	COG1366	Belongs to the anti-sigma-factor antagonist family
S101359_RS11945	COG1686	Belongs to the peptidase S11 family
S101359_RS11950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S101359_RS11955	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S101359_RS11960	COG4974	Belongs to the 'phage' integrase family
S101359_RS11970	COG0735	belongs to the Fur family
S101359_RS11975	COG1300	Membrane
S101359_RS11985	COG0281	malic enzyme
S101359_RS11990	COG1757	Na H antiporter
S101359_RS11995	COG1027	Aspartate ammonia-lyase
S101359_RS12000	COG0252	asparaginase activity
S101359_RS12005	COG1396	sequence-specific DNA binding
S101359_RS12010	COG1379	DNA repair
S101359_RS12015	COG0494	nUDIX hydrolase
S101359_RS12025	COG0667	Aldo Keto reductase
S101359_RS12035	COG1073	alpha beta
S101359_RS12045	COG4918	Iron-sulphur cluster biosynthesis
S101359_RS12050	COG0456	acetyltransferase
S101359_RS12050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S101359_RS12055	COG2329	Antibiotic biosynthesis monooxygenase
S101359_RS12060	COG0456	acetyltransferase
S101359_RS12070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101359_RS12080	COG0628	permease
S101359_RS12090	COG2211	Major facilitator Superfamily
S101359_RS12100	COG0346	lactoylglutathione lyase activity
S101359_RS12105	COG1072	(Pantothenic acid kinase))
S101359_RS12110	COG3048	D-serine ammonia-lyase activity
S101359_RS12115	COG0300	oxidoreductase activity
S101359_RS12120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101359_RS12125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101359_RS12130	COG4187	Peptidase family M20/M25/M40
S101359_RS12135	COG1902	pentaerythritol trinitrate reductase activity
S101359_RS12140	COG0596	Alpha beta hydrolase
S101359_RS12150	COG1234	tRNA 3'-trailer cleavage
S101359_RS12155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S101359_RS12160	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S101359_RS12165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101359_RS12175	COG0706	membrane insertase activity
S101359_RS12180	COG3361	conserved protein (COG2071)
S101359_RS12185	COG2195	Cleaves the N-terminal amino acid of tripeptides
S101359_RS12190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S101359_RS12195	COG0346	lactoylglutathione lyase activity
S101359_RS12200	COG1376	ErfK ybiS ycfS ynhG family protein
S101359_RS12205	COG4129	membrane
S101359_RS12210	COG1126	abc transporter atp-binding protein
S101359_RS12215	COG0765	amino acid transport
S101359_RS12220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101359_RS12230	COG1597	lipid kinase activity
S101359_RS12240	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101359_RS12245	COG0022	dehydrogenase e1 component
S101359_RS12250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101359_RS12255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101359_RS12260	COG3426	butyrate kinase activity
S101359_RS12265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101359_RS12270	COG0280	phosphate acetyltransferase
S101359_RS12275	COG3290	protein histidine kinase activity
S101359_RS12275	COG3829	transcription factor binding
S101359_RS12285	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S101359_RS12290	COG2079	MmgE PrpD family protein
S101359_RS12295	COG0372	Belongs to the citrate synthase family
S101359_RS12300	COG1960	acyl-CoA dehydrogenase activity
S101359_RS12305	COG1250	3-hydroxyacyl-CoA dehydrogenase
S101359_RS12310	COG0183	Belongs to the thiolase family
S101359_RS12315	COG0584	glycerophosphoryl diester phosphodiesterase
S101359_RS12320	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101359_RS12330	COG1902	pentaerythritol trinitrate reductase activity
S101359_RS12340	COG0745	RESPONSE REGULATOR receiver
S101359_RS12345	COG0750	zinc metalloprotease
S101359_RS12350	COG0497	DNA recombination
S101359_RS12355	COG1438	arginine binding
S101359_RS12360	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S101359_RS12365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S101359_RS12370	COG0142	geranyltranstransferase activity
S101359_RS12375	COG1722	exodeoxyribonuclease VII activity
S101359_RS12380	COG1570	exodeoxyribonuclease VII activity
S101359_RS12385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S101359_RS12390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101359_RS12395	COG1302	Protein conserved in bacteria
S101359_RS12400	COG0439	Biotin carboxylase
S101359_RS12405	COG0511	ligase activity, forming carbon-carbon bonds
S101359_RS12445	COG3854	ATPases associated with a variety of cellular activities
S101359_RS12455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S101359_RS12460	COG0006	proline dipeptidase activity
S101359_RS12465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S101359_RS12475	COG3872	metal-dependent enzyme
S101359_RS12485	COG1752	Esterase of the alpha-beta hydrolase superfamily
S101359_RS12490	COG1321	iron dependent repressor
S101359_RS12495	COG0095	Lipoate-protein ligase
S101359_RS12500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S101359_RS12505	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S101359_RS12510	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S101359_RS12515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S101359_RS12520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S101359_RS12535	COG1396	sequence-specific DNA binding
S101359_RS12545	COG0681	Belongs to the peptidase S26 family
S101359_RS12570	COG4940	Competence protein ComGF
S101359_RS12580	COG4970	Tfp pilus assembly protein FimT
S101359_RS12585	COG4537	Required for transformation and DNA binding
S101359_RS12590	COG1459	type II secretion system
S101359_RS12595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S101359_RS12605	COG0598	Magnesium transport protein CorA
S101359_RS12610	COG1253	flavin adenine dinucleotide binding
S101359_RS12615	COG1366	Belongs to the anti-sigma-factor antagonist family
S101359_RS12625	COG1393	Belongs to the ArsC family
S101359_RS12635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101359_RS12645	COG0011	TIGRFAM Protein of
S101359_RS12655	COG2866	Carboxypeptidase
S101359_RS12660	COG1368	sulfuric ester hydrolase activity
S101359_RS12665	COG1940	carbohydrate kinase activity
S101359_RS12670	COG4483	Protein conserved in bacteria
S101359_RS12675	COG0705	Rhomboid family
S101359_RS12675	COG0457	Tetratricopeptide repeat
S101359_RS12685	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S101359_RS12695	COG0438	transferase activity, transferring glycosyl groups
S101359_RS12710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S101359_RS12715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101359_RS12720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101359_RS12725	COG0581	inorganic phosphate transmembrane transporter activity
S101359_RS12730	COG0573	inorganic phosphate transmembrane transporter activity
S101359_RS12735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S101359_RS12740	COG0768	penicillin binding
S101359_RS12745	COG0477	Major facilitator Superfamily
S101359_RS12750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S101359_RS12755	COG2839	Protein conserved in bacteria
S101359_RS12760	COG5521	maltodextrose utilization protein MalA
S101359_RS12765	COG1388	LysM domain
S101359_RS12775	COG4709	membrane
S101359_RS12780	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
S101359_RS12785	COG0735	belongs to the Fur family
S101359_RS12790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101359_RS12800	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S101359_RS12805	COG0513	Belongs to the DEAD box helicase family
S101359_RS12815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S101359_RS12820	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S101359_RS12825	COG2384	SAM-dependent methyltransferase
S101359_RS12830	COG2010	Cytochrome c
S101359_RS12835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S101359_RS12840	COG0358	DNA primase activity
S101359_RS12845	COG1671	Belongs to the UPF0178 family
S101359_RS12850	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S101359_RS12855	COG0517	IMP dehydrogenase activity
S101359_RS12860	COG0751	glycine-tRNA ligase activity
S101359_RS12865	COG0752	glycyl-tRNA synthetase alpha subunit
S101359_RS12870	COG1381	Involved in DNA repair and RecF pathway recombination
S101359_RS12880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S101359_RS12885	COG0295	cytidine deaminase activity
S101359_RS12890	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S101359_RS12900	COG1480	7TM receptor with intracellular HD hydrolase
S101359_RS12905	COG1702	phosphate starvation-inducible protein PhoH
S101359_RS12910	COG0561	phosphatase activity
S101359_RS12925	COG4864	UPF0365 protein
S101359_RS12930	COG1030	water channel activity
S101359_RS12935	COG1610	YqeY-like protein
S101359_RS12945	COG1283	sodium-dependent phosphate transmembrane transporter activity
S101359_RS12950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S101359_RS12955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S101359_RS12975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S101359_RS12980	COG1420	regulation of RNA biosynthetic process
S101359_RS12985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S101359_RS12990	COG0481	GTPase activity
S101359_RS13000	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101359_RS13015	COG1466	dna polymerase III delta subunit
S101359_RS13025	COG0658	competence protein
S101359_RS13025	COG2333	competence protein COMEC
S101359_RS13030	COG2131	deaminase
S101359_RS13035	COG1555	photosystem II stabilization
S101359_RS13035	COG1596	polysaccharide export
S101359_RS13040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101359_RS13045	COG2226	methyltransferase
S101359_RS13050	COG0799	negative regulation of ribosome biogenesis
S101359_RS13055	COG1713	HD superfamily hydrolase involved in NAD metabolism
S101359_RS13060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S101359_RS13065	COG1534	Rna-binding protein
S101359_RS13070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S101359_RS13075	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S101359_RS13080	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
S101359_RS13090	COG2755	lipolytic protein G-D-S-L family
S101359_RS13105	COG0398	Pfam SNARE associated Golgi protein
S101359_RS13130	COG3299	homolog of phage Mu protein gp47
S101359_RS13225	COG2124	cytochrome p450
S101359_RS13230	COG1309	transcriptional regulator
S101359_RS13235	COG2732	(Barnase) inhibitor
S101359_RS13260	COG1725	Transcriptional regulator
S101359_RS13275	COG0583	DNA-binding transcription factor activity
S101359_RS13300	COG3443	Belongs to the bacterial solute-binding protein 9 family
S101359_RS13315	COG0583	DNA-binding transcription factor activity
S101359_RS13320	COG2814	Major facilitator Superfamily
S101359_RS13325	COG2176	DNA-directed DNA polymerase activity
S101359_RS13330	COG2124	cytochrome p450
S101359_RS13330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S101359_RS13335	COG1309	transcriptional regulator
S101359_RS13340	COG2226	methyltransferase
S101359_RS13350	COG2116	formate transmembrane transporter activity
S101359_RS13360	COG5609	conserved protein (DUF2294)
S101359_RS13365	COG3383	formate dehydrogenase (NAD+) activity
S101359_RS13370	COG2427	Protein of unknown function (DUF1641)
S101359_RS13380	COG0626	cystathionine gamma-synthase activity
S101359_RS13385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101359_RS13390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S101359_RS13395	COG2226	methyltransferase
S101359_RS13410	COG0768	penicillin binding
S101359_RS13415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S101359_RS13420	COG0572	uridine kinase
S101359_RS13425	COG0826	peptidase U32
S101359_RS13430	COG0826	peptidase U32
S101359_RS13435	COG4122	O-methyltransferase activity
S101359_RS13440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S101359_RS13445	COG3906	Belongs to the UPF0473 family
S101359_RS13450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S101359_RS13455	COG4472	Bacterial protein of unknown function (DUF965)
S101359_RS13460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S101359_RS13465	COG0628	permease
S101359_RS13470	COG1126	abc transporter atp-binding protein
S101359_RS13475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101359_RS13480	COG0765	amino acid transport
S101359_RS13485	COG0765	amino acid transport
S101359_RS13500	COG3881	PFAM PRC-barrel domain
S101359_RS13505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S101359_RS13510	COG0457	Tetratricopeptide repeat
S101359_RS13520	COG1104	cysteine desulfurase activity
S101359_RS13525	COG1959	2 iron, 2 sulfur cluster binding
S101359_RS13530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S101359_RS13535	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S101359_RS13545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S101359_RS13560	COG3103	Sh3 type 3 domain protein
S101359_RS13560	COG4991	sh3 domain protein
S101359_RS13560	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101359_RS13565	COG1490	D-aminoacyl-tRNA deacylase activity
S101359_RS13570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S101359_RS13580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S101359_RS13580	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S101359_RS13585	COG5416	Lipopolysaccharide assembly protein A domain
S101359_RS13590	COG0490	domain, Protein
S101359_RS13595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S101359_RS13595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S101359_RS13605	COG2244	polysaccharide biosynthetic process
S101359_RS13610	COG2323	membrane
S101359_RS13620	COG1862	Preprotein translocase
S101359_RS13630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S101359_RS13640	COG2255	four-way junction helicase activity
S101359_RS13645	COG0632	four-way junction helicase activity
S101359_RS13655	COG2814	Major facilitator Superfamily
S101359_RS13660	COG2112	serine threonine protein kinase
S101359_RS13680	COG0217	transcriptional regulatory protein
S101359_RS13700	COG3394	polysaccharide catabolic process
S101359_RS13705	COG2188	Transcriptional regulator
S101359_RS13710	COG1486	melibiose metabolic process
S101359_RS13715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101359_RS13720	COG1447	Phosphotransferase system cellobiose-specific component IIA
S101359_RS13725	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101359_RS13740	COG1388	LysM domain
S101359_RS13745	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S101359_RS13750	COG0157	Belongs to the NadC ModD family
S101359_RS13755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S101359_RS13760	COG1104	cysteine desulfurase activity
S101359_RS13765	COG1827	regulation of RNA biosynthetic process
S101359_RS13770	COG0077	Prephenate dehydratase
S101359_RS13775	COG4492	Belongs to the UPF0735 family
S101359_RS13780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S101359_RS13785	COG3290	protein histidine kinase activity
S101359_RS13790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S101359_RS13795	COG2868	ribosomal protein
S101359_RS13800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S101359_RS13805	COG1994	Peptidase M50
S101359_RS13810	COG0739	heme binding
S101359_RS13815	COG2894	cell division
S101359_RS13820	COG0850	regulation of cytokinetic process
S101359_RS13825	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
S101359_RS13835	COG1077	Cell shape determining protein MreB Mrl
S101359_RS13840	COG2003	Belongs to the UPF0758 family
S101359_RS13845	COG0424	maF-like protein
S101359_RS13855	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S101359_RS13860	COG0285	dihydrofolate synthase activity
S101359_RS13865	COG0525	valine-tRNA ligase activity
S101359_RS13875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101359_RS13880	COG1388	LysM domain
S101359_RS13885	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S101359_RS13890	COG0113	porphobilinogen synthase activity
S101359_RS13895	COG1587	Uroporphyrinogen-III synthase
S101359_RS13905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S101359_RS13910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S101359_RS13920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S101359_RS13925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S101359_RS13930	COG0470	DNA polymerase III
S101359_RS13930	COG1067	ATP-dependent peptidase activity
S101359_RS13940	COG0544	peptidyl-prolyl cis-trans isomerase activity
S101359_RS13945	COG1477	protein flavinylation
S101359_RS13945	COG0457	Tetratricopeptide repeat
S101359_RS13950	COG0066	3-isopropylmalate dehydratase activity
S101359_RS13955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S101359_RS13960	COG0473	3-isopropylmalate dehydrogenase activity
S101359_RS13965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S101359_RS13970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S101359_RS13975	COG0440	acetolactate synthase activity
S101359_RS13980	COG0028	Belongs to the TPP enzyme family
S101359_RS13990	COG0454	-acetyltransferase
S101359_RS13995	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
S101359_RS14005	COG0622	Phosphoesterase
S101359_RS14010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S101359_RS14015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S101359_RS14020	COG5401	PFAM Sporulation and spore germination
S101359_RS14025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S101359_RS14030	COG1846	Transcriptional regulator
S101359_RS14035	COG2197	response regulator
S101359_RS14040	COG0824	Thioesterase
S101359_RS14045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S101359_RS14050	COG1053	succinate dehydrogenase
S101359_RS14055	COG2009	succinate dehydrogenase
S101359_RS14060	COG1719	4-vinyl reductase, 4VR
S101359_RS14065	COG0527	aspartate kinase activity
S101359_RS14070	COG0322	excinuclease ABC activity
S101359_RS14075	COG3118	belongs to the thioredoxin family
S101359_RS14080	COG3534	alpha-L-arabinofuranosidase
S101359_RS14085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S101359_RS14090	COG2086	electron transfer activity
S101359_RS14095	COG1024	Enoyl-CoA hydratase
S101359_RS14100	COG1309	transcriptional regulator
S101359_RS14105	COG0318	PFAM AMP-dependent synthetase and ligase
S101359_RS14115	COG3766	membrane
S101359_RS14120	COG1193	negative regulation of DNA recombination
S101359_RS14125	COG1796	DNA polymerase
S101359_RS14125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S101359_RS14130	COG1286	toxin biosynthetic process
S101359_RS14135	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
S101359_RS14145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101359_RS14145	COG0072	phenylalanine-tRNA ligase activity
S101359_RS14150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S101359_RS14155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S101359_RS14165	COG3835	regulator
S101359_RS14170	COG0277	FAD linked oxidase domain protein
S101359_RS14175	COG0247	lactate metabolic process
S101359_RS14180	COG0346	lactoylglutathione lyase activity
S101359_RS14185	COG1966	Carbon starvation protein
S101359_RS14190	COG3534	alpha-L-arabinofuranosidase
S101359_RS14195	COG0395	ABC-type sugar transport system, permease component
S101359_RS14200	COG1175	transmembrane transport
S101359_RS14205	COG1653	transport
S101359_RS14210	COG0371	Dehydrogenase
S101359_RS14215	COG0647	UMP catabolic process
S101359_RS14220	COG0235	Class ii aldolase
S101359_RS14225	COG1069	ribulokinase activity
S101359_RS14230	COG2160	L-arabinose isomerase activity
S101359_RS14255	COG3507	Belongs to the glycosyl hydrolase 43 family
S101359_RS14260	COG1363	Peptidase, m42
S101359_RS14270	COG3326	Membrane
S101359_RS14275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S101359_RS14280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S101359_RS14285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S101359_RS14305	COG1346	cytolysis
S101359_RS14315	COG3279	Response regulator of the LytR AlgR family
S101359_RS14320	COG3275	phosphorelay sensor kinase activity
S101359_RS14325	COG1011	Hydrolase
S101359_RS14330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S101359_RS14340	COG0398	Pfam SNARE associated Golgi protein
S101359_RS14345	COG1484	DNA-dependent DNA replication
S101359_RS14350	COG3611	Membrane attachment protein
S101359_RS14355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S101359_RS14360	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S101359_RS14365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S101359_RS14370	COG1733	regulation of RNA biosynthetic process
S101359_RS14375	COG2814	Major facilitator Superfamily
S101359_RS14380	COG0656	L-ascorbic acid biosynthetic process
S101359_RS14385	COG0237	dephospho-CoA kinase activity
S101359_RS14390	COG1971	Probably functions as a manganese efflux pump
S101359_RS14395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S101359_RS14400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101359_RS14400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101359_RS14405	COG5002	protein histidine kinase activity
S101359_RS14410	COG0745	RESPONSE REGULATOR receiver
S101359_RS14420	COG0538	isocitrate dehydrogenase activity
S101359_RS14425	COG0372	Belongs to the citrate synthase family
S101359_RS14430	COG2707	UPF0756 membrane protein
S101359_RS14435	COG0628	permease
S101359_RS14440	COG3030	protein affecting phage T7 exclusion by the F plasmid
S101359_RS14445	COG0469	pyruvate kinase activity
S101359_RS14450	COG0205	6-phosphofructokinase activity
S101359_RS14455	COG0825	malonyl-CoA metabolic process
S101359_RS14460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S101359_RS14465	COG0281	malic enzyme
S101359_RS14470	COG0587	DNA-directed DNA polymerase activity
S101359_RS14490	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S101359_RS14500	COG4109	DRTGG domain
S101359_RS14505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S101359_RS14510	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS14520	COG0165	Argininosuccinate lyase
S101359_RS14525	COG0137	argininosuccinate synthase activity
S101359_RS14530	COG0521	Mo-molybdopterin cofactor biosynthetic process
S101359_RS14540	COG0827	DNA restriction-modification system
S101359_RS14545	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
S101359_RS14550	COG3874	Sporulation protein YtfJ
S101359_RS14560	COG1714	RDD family
S101359_RS14565	COG0616	signal peptide processing
S101359_RS14570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S101359_RS14575	COG1574	metal-dependent hydrolase with the TIM-barrel fold
S101359_RS14580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S101359_RS14590	COG0301	tRNA thio-modification
S101359_RS14595	COG1104	cysteine desulfurase activity
S101359_RS14600	COG1114	Component of the transport system for branched-chain amino acids
S101359_RS14605	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S101359_RS14610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S101359_RS14615	COG1309	transcriptional regulator
S101359_RS14620	COG1956	GAF domain-containing protein
S101359_RS14625	COG2199	diguanylate cyclase activity
S101359_RS14625	COG2203	Gaf domain
S101359_RS14640	COG2323	membrane
S101359_RS14650	COG0697	spore germination
S101359_RS14655	COG0583	DNA-binding transcription factor activity
S101359_RS14660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S101359_RS14670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S101359_RS14675	COG0454	-acetyltransferase
S101359_RS14680	COG0517	IMP dehydrogenase activity
S101359_RS14685	COG0123	including yeast histone deacetylase and acetoin utilization protein
S101359_RS14690	COG1360	Flagellar Motor Protein
S101359_RS14695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S101359_RS14700	COG1609	Transcriptional regulator
S101359_RS14705	COG1605	Chorismate mutase
S101359_RS14705	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
S101359_RS14710	COG3118	belongs to the thioredoxin family
S101359_RS14715	COG4980	gas vesicle protein
S101359_RS14720	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S101359_RS14730	COG1674	ftsk spoiiie
S101359_RS14735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101359_RS14740	COG4848	Belongs to the UPF0354 family
S101359_RS14745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101359_RS14755	COG1363	Peptidase, m42
S101359_RS14760	COG5584	Small secreted protein
S101359_RS14765	COG0281	malic enzyme
S101359_RS14770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101359_RS14775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S101359_RS14785	COG0510	thiamine kinase activity
S101359_RS14790	COG1523	belongs to the glycosyl hydrolase 13 family
S101359_RS14795	COG1597	lipid kinase activity
S101359_RS14805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S101359_RS14810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101359_RS14815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101359_RS14820	COG2252	PERMEase
S101359_RS14825	COG1349	DNA-binding transcription factor activity
S101359_RS14830	COG1187	pseudouridine synthase activity
S101359_RS14835	COG2244	polysaccharide biosynthetic process
S101359_RS14840	COG2081	HI0933 family
S101359_RS14845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
S101359_RS14855	COG5578	integral membrane protein
S101359_RS14860	COG0673	inositol 2-dehydrogenase activity
S101359_RS14865	COG1653	transport
S101359_RS14870	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S101359_RS14875	COG4209	transmembrane transport
S101359_RS14880	COG2207	Transcriptional regulator
S101359_RS14885	COG1653	transport
S101359_RS14890	COG0395	ABC-type sugar transport system, permease component
S101359_RS14895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101359_RS14900	COG2124	cytochrome p450
S101359_RS14905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S101359_RS14915	COG0156	8-amino-7-oxononanoate synthase activity
S101359_RS14920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101359_RS14925	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
S101359_RS14930	COG1073	alpha beta
S101359_RS14935	COG1653	transport
S101359_RS14940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S101359_RS14945	COG0495	leucyl-tRNA aminoacylation
S101359_RS14955	COG1366	Belongs to the anti-sigma-factor antagonist family
S101359_RS14955	COG2202	Pas domain
S101359_RS14960	COG2814	Major facilitator Superfamily
S101359_RS14965	COG2433	Pfam Transposase IS66
S101359_RS14970	COG0577	efflux transmembrane transporter activity
S101359_RS14975	COG1136	(ABC) transporter
S101359_RS14980	COG2205	protein histidine kinase activity
S101359_RS14985	COG0745	RESPONSE REGULATOR receiver
S101359_RS14990	COG0577	efflux transmembrane transporter activity
S101359_RS14995	COG1136	(ABC) transporter
S101359_RS15005	COG1131	(ABC) transporter
S101359_RS15010	COG1725	Transcriptional regulator
S101359_RS15045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S101359_RS15050	COG0477	Major facilitator Superfamily
S101359_RS15055	COG1242	4 iron, 4 sulfur cluster binding
S101359_RS15060	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S101359_RS15070	COG2267	carboxylic ester hydrolase activity
S101359_RS15075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S101359_RS15080	COG1113	amino acid transport
S101359_RS15085	COG0367	asparagine synthase
S101359_RS15095	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S101359_RS15105	COG1506	peptidase
S101359_RS15110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101359_RS15115	COG1116	anion transmembrane transporter activity
S101359_RS15120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101359_RS15125	COG0494	nUDIX hydrolase
S101359_RS15135	COG4824	toxin secretion phage lysis holin
S101359_RS15140	COG0783	Belongs to the Dps family
S101359_RS15160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S101359_RS15165	COG0288	reversible hydration of carbon dioxide
S101359_RS15170	COG0523	cobalamin synthesis protein
S101359_RS15180	COG1271	oxidase subunit
S101359_RS15185	COG1294	oxidase, subunit
S101359_RS15195	COG4305	rare lipoprotein A
S101359_RS15200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101359_RS15205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101359_RS15205	COG1321	iron dependent repressor
S101359_RS15210	COG1121	(ABC) transporter
S101359_RS15215	COG0803	Belongs to the bacterial solute-binding protein 9 family
S101359_RS15220	COG4948	Mandelate Racemase Muconate Lactonizing
S101359_RS15225	COG0318	PFAM AMP-dependent synthetase and ligase
S101359_RS15230	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S101359_RS15235	COG0596	Alpha beta hydrolase
S101359_RS15240	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
S101359_RS15245	COG1169	isochorismate synthase
S101359_RS15250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101359_RS15255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101359_RS15260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101359_RS15265	COG0438	transferase activity, transferring glycosyl groups
S101359_RS15275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101359_RS15280	COG0438	transferase activity, transferring glycosyl groups
S101359_RS15285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101359_RS15290	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S101359_RS15295	COG0058	SHG alpha-glucan phosphorylase activity
S101359_RS15300	COG0297	glycogen (starch) synthase activity
S101359_RS15305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S101359_RS15310	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S101359_RS15315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S101359_RS15440	COG3859	Proton-coupled thiamine transporter YuaJ
S101359_RS15445	COG3764	Sortase (surface protein transpeptidase)
S101359_RS15455	COG2268	Band 7 protein
S101359_RS15460	COG1585	Membrane protein implicated in regulation of membrane protease activity
S101359_RS15465	COG2318	DinB family
S101359_RS15475	COG1454	alcohol dehydrogenase
S101359_RS15480	COG1012	belongs to the aldehyde dehydrogenase family
S101359_RS15485	COG1510	regulation of RNA biosynthetic process
S101359_RS15495	COG0569	domain protein
S101359_RS15500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S101359_RS15510	COG1705	Flagellar rod assembly protein muramidase FlgJ
S101359_RS15515	COG0477	Major facilitator Superfamily
S101359_RS15530	COG0628	permease
S101359_RS15535	COG0673	inositol 2-dehydrogenase activity
S101359_RS15540	COG0693	protein deglycase activity
S101359_RS15545	COG4806	L-rhamnose isomerase
S101359_RS15550	COG3254	rhamnose metabolic process
S101359_RS15555	COG1070	Carbohydrate kinase
S101359_RS15560	COG1349	DNA-binding transcription factor activity
S101359_RS15565	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS15565	COG3347	Dehydrogenase
S101359_RS15570	COG0840	transmembrane signaling receptor activity
S101359_RS15575	COG0840	transmembrane signaling receptor activity
S101359_RS15580	COG0840	transmembrane signaling receptor activity
S101359_RS15585	COG0840	transmembrane signaling receptor activity
S101359_RS15600	COG2070	2-Nitropropane dioxygenase
S101359_RS15605	COG0432	Pfam Uncharacterised protein family UPF0047
S101359_RS15610	COG0366	Alpha amylase catalytic
S101359_RS15615	COG1253	flavin adenine dinucleotide binding
S101359_RS15620	COG2738	Putative neutral zinc metallopeptidase
S101359_RS15635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S101359_RS15650	COG0166	Belongs to the GPI family
S101359_RS15655	COG1979	alcohol dehydrogenase
S101359_RS15660	COG1979	alcohol dehydrogenase
S101359_RS15665	COG2155	Conserved Protein
S101359_RS15670	COG1098	S1 RNA binding domain
S101359_RS15675	COG0436	Aminotransferase
S101359_RS15680	COG1522	sequence-specific DNA binding
S101359_RS15685	COG2267	carboxylic ester hydrolase activity
S101359_RS15695	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S101359_RS15700	COG2205	protein histidine kinase activity
S101359_RS15710	COG5018	Exonuclease
S101359_RS15720	COG2814	Major facilitator Superfamily
S101359_RS15725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101359_RS15730	COG3011	Protein conserved in bacteria
S101359_RS15740	COG3290	protein histidine kinase activity
S101359_RS15745	COG4565	transcriptional regulatory protein
S101359_RS15750	COG1744	ABC transporter substrate-binding protein PnrA-like
S101359_RS15755	COG3845	ABC transporter
S101359_RS15760	COG4603	Belongs to the binding-protein-dependent transport system permease family
S101359_RS15765	COG1079	Belongs to the binding-protein-dependent transport system permease family
S101359_RS15770	COG3493	citrate carrier protein
S101359_RS15780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S101359_RS15780	COG2111	Na H antiporter
S101359_RS15785	COG2111	Na H antiporter
S101359_RS15790	COG1006	Multisubunit Na H antiporter MnhC subunit
S101359_RS15795	COG0651	ATP synthesis coupled electron transport
S101359_RS15800	COG1863	multisubunit Na H antiporter MnhE subunit
S101359_RS15805	COG2212	antiporter activity
S101359_RS15810	COG1320	monovalent cation:proton antiporter activity
S101359_RS15815	COG2050	protein possibly involved in aromatic compounds catabolism
S101359_RS15820	COG2197	response regulator
S101359_RS15825	COG4585	Histidine kinase
S101359_RS15835	COG0142	geranyltranstransferase activity
S101359_RS15850	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S101359_RS15855	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S101359_RS15860	COG1335	isochorismatase
S101359_RS15865	COG5506	Protein of unknown function (DUF1694)
S101359_RS15880	COG0628	permease
S101359_RS15890	COG1418	mRNA catabolic process
S101359_RS15895	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS15905	COG1511	domain protein
S101359_RS15910	COG0433	COG0433 Predicted ATPase
S101359_RS15910	COG1674	ftsk spoiiie
S101359_RS15915	COG4499	WXG100 protein secretion system (Wss), protein YukC
S101359_RS15920	COG5417	Belongs to the EsaB family
S101359_RS15925	COG4842	Belongs to the WXG100 family
S101359_RS15930	COG2508	Transcriptional regulator
S101359_RS15930	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S101359_RS15935	COG0686	Belongs to the AlaDH PNT family
S101359_RS15940	COG5634	Uncharacterized conserved protein (DUF2278)
S101359_RS15945	COG3251	PFAM MbtH domain protein
S101359_RS15950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS15955	COG3433	isochorismatase activity
S101359_RS15955	COG1535	isochorismatase
S101359_RS15960	COG1021	2,3-dihydroxybenzoate-AMP ligase
S101359_RS15965	COG1169	isochorismate synthase
S101359_RS15970	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS15975	COG2819	hydrolase of the alpha beta superfamily
S101359_RS15990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S101359_RS15995	COG1268	BioY protein
S101359_RS16000	COG2056	Na+-H+ antiporter family
S101359_RS16005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S101359_RS16010	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
S101359_RS16015	COG3584	3D domain protein
S101359_RS16030	COG1252	NADH dehydrogenase
S101359_RS16045	COG0516	GMP reductase activity
S101359_RS16070	COG0316	Belongs to the HesB IscA family
S101359_RS16075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S101359_RS16080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101359_RS16085	COG4844	belongs to the
S101359_RS16090	COG1252	NADH dehydrogenase
S101359_RS16095	COG3479	Phenolic acid decarboxylase
S101359_RS16100	COG4837	Protein of unknown function (DUF1462)
S101359_RS16105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S101359_RS16110	COG1506	peptidase
S101359_RS16110	COG4946	Tricorn protease homolog
S101359_RS16110	COG0823	Involved in the tonB-independent uptake of proteins
S101359_RS16115	COG0083	homoserine kinase activity
S101359_RS16120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S101359_RS16125	COG0460	homoserine dehydrogenase
S101359_RS16130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101359_RS16135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S101359_RS16140	COG0647	UMP catabolic process
S101359_RS16145	COG2445	Protein of unknown function DUF86
S101359_RS16150	COG4470	Protein conserved in bacteria
S101359_RS16165	COG0739	heme binding
S101359_RS16175	COG3377	Domain of unknown function (DUF1805)
S101359_RS16180	COG0737	Belongs to the 5'-nucleotidase family
S101359_RS16185	COG0730	response to heat
S101359_RS16190	COG1801	Protein of unknown function DUF72
S101359_RS16200	COG1819	glycosyl
S101359_RS16205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S101359_RS16210	COG2508	Transcriptional regulator
S101359_RS16220	COG1595	DNA-templated transcription, initiation
S101359_RS16275	COG1131	(ABC) transporter
S101359_RS16290	COG2814	Major facilitator Superfamily
S101359_RS16295	COG0583	DNA-binding transcription factor activity
S101359_RS16305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S101359_RS16310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101359_RS16315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S101359_RS16320	COG2356	endonuclease I
S101359_RS16330	COG3842	ATPase activity
S101359_RS16335	COG2188	Transcriptional regulator
S101359_RS16340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101359_RS16345	COG0395	ABC-type sugar transport system, permease component
S101359_RS16350	COG1175	transmembrane transport
S101359_RS16360	COG2222	sugar isomerase
S101359_RS16365	COG0322	excinuclease ABC activity
S101359_RS16370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101359_RS16390	COG0719	Fe-S assembly protein
S101359_RS16395	COG0822	iron-sulfur transferase activity
S101359_RS16400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S101359_RS16405	COG0719	Fe-S assembly protein
S101359_RS16410	COG0396	ATPase activity
S101359_RS16415	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S101359_RS16420	COG1464	Belongs to the NlpA lipoprotein family
S101359_RS16425	COG2011	ABC-type metal ion transport system permease component
S101359_RS16430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S101359_RS16440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101359_RS16445	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S101359_RS16455	COG0509	glycine decarboxylation via glycine cleavage system
S101359_RS16460	COG1393	Belongs to the ArsC family
S101359_RS16465	COG1960	acyl-CoA dehydrogenase activity
S101359_RS16470	COG0183	Belongs to the thiolase family
S101359_RS16475	COG1024	Enoyl-CoA hydratase
S101359_RS16475	COG1250	3-hydroxyacyl-CoA dehydrogenase
S101359_RS16495	COG5577	PFAM Coat F domain
S101359_RS16500	COG1846	Transcriptional regulator
S101359_RS16505	COG0477	Major facilitator Superfamily
S101359_RS16515	COG1120	ATPase activity
S101359_RS16530	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS16535	COG0783	Belongs to the Dps family
S101359_RS16540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101359_RS16545	COG0745	RESPONSE REGULATOR receiver
S101359_RS16550	COG2205	protein histidine kinase activity
S101359_RS16550	COG2770	Histidine kinase
S101359_RS16560	COG1309	transcriptional regulator
S101359_RS16565	COG0114	fumarate hydratase activity
S101359_RS16575	COG0697	spore germination
S101359_RS16580	COG0814	amino acid
S101359_RS16590	COG2197	response regulator
S101359_RS16595	COG4585	Histidine kinase
S101359_RS16600	COG4758	membrane
S101359_RS16605	COG3595	metallopeptidase activity
S101359_RS16610	COG1842	Phage shock protein A
S101359_RS16615	COG4758	membrane
S101359_RS16620	COG2814	Major facilitator Superfamily
S101359_RS16625	COG2096	Adenosyltransferase
S101359_RS16630	COG1120	ATPase activity
S101359_RS16635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS16640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101359_RS16645	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS16650	COG3386	PFAM SMP-30 Gluconolaconase
S101359_RS16655	COG2205	protein histidine kinase activity
S101359_RS16660	COG0745	RESPONSE REGULATOR receiver
S101359_RS16670	COG1191	sigma factor activity
S101359_RS16680	COG2140	Oxalate decarboxylase
S101359_RS16690	COG0577	efflux transmembrane transporter activity
S101359_RS16695	COG1136	(ABC) transporter
S101359_RS16700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101359_RS16705	COG1120	ATPase activity
S101359_RS16710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS16715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101359_RS16720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101359_RS16730	COG0531	amino acid
S101359_RS16745	COG1988	membrane-bound metal-dependent
S101359_RS16750	COG1368	sulfuric ester hydrolase activity
S101359_RS16755	COG1910	domain protein
S101359_RS16760	COG0725	ABC transporter, periplasmic molybdate-binding protein
S101359_RS16765	COG4149	molybdate abc transporter
S101359_RS16775	COG0656	L-ascorbic acid biosynthetic process
S101359_RS16800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S101359_RS16805	COG3973	AAA domain
S101359_RS16810	COG2860	membrane
S101359_RS16820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S101359_RS16825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S101359_RS16830	COG2217	Heavy metal translocating P-type atpase
S101359_RS16835	COG2217	Heavy metal translocating P-type atpase
S101359_RS16840	COG2608	mercury ion transmembrane transporter activity
S101359_RS16845	COG1937	Protein conserved in bacteria
S101359_RS16850	COG0673	inositol 2-dehydrogenase activity
S101359_RS16860	COG1289	transmembrane transporter activity
S101359_RS16870	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS16885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S101359_RS16890	COG0557	exoribonuclease II activity
S101359_RS16895	COG1647	Serine aminopeptidase, S33
S101359_RS16900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S101359_RS16905	COG1476	TRANSCRIPTIONal
S101359_RS16910	COG1396	sequence-specific DNA binding
S101359_RS16915	COG1396	sequence-specific DNA binding
S101359_RS16920	COG1733	regulation of RNA biosynthetic process
S101359_RS16925	COG0840	transmembrane signaling receptor activity
S101359_RS16930	COG1174	glycine betaine transport
S101359_RS16935	COG1732	Glycine betaine
S101359_RS16940	COG1174	glycine betaine transport
S101359_RS16945	COG1125	glycine betaine transport
S101359_RS16945	COG0517	IMP dehydrogenase activity
S101359_RS16950	COG1510	regulation of RNA biosynthetic process
S101359_RS16955	COG1174	glycine betaine transport
S101359_RS16960	COG1732	Glycine betaine
S101359_RS16965	COG1174	glycine betaine transport
S101359_RS16970	COG0517	IMP dehydrogenase activity
S101359_RS16970	COG1125	glycine betaine transport
S101359_RS16975	COG1510	regulation of RNA biosynthetic process
S101359_RS16985	COG3064	Membrane
S101359_RS16990	COG4640	response to antibiotic
S101359_RS16995	COG0456	acetyltransferase
S101359_RS17010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101359_RS17030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101359_RS17035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101359_RS17045	COG2234	aminopeptidase activity
S101359_RS17055	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S101359_RS17060	COG0149	triose-phosphate isomerase activity
S101359_RS17065	COG0126	phosphoglycerate kinase activity
S101359_RS17070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S101359_RS17075	COG2390	Transcriptional regulator
S101359_RS17080	COG2814	Major facilitator Superfamily
S101359_RS17085	COG1609	Transcriptional regulator
S101359_RS17090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101359_RS17095	COG0583	DNA-binding transcription factor activity
S101359_RS17100	COG0697	spore germination
S101359_RS17105	COG1113	amino acid transport
S101359_RS17110	COG3858	chitin binding
S101359_RS17115	COG1556	Lactate utilization protein
S101359_RS17120	COG1139	Iron-sulfur cluster binding protein
S101359_RS17125	COG0247	lactate metabolic process
S101359_RS17130	COG2208	phosphoserine phosphatase activity
S101359_RS17135	COG2186	Transcriptional regulator
S101359_RS17140	COG1620	l-lactate permease
S101359_RS17145	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S101359_RS17155	COG5039	Polysaccharide pyruvyl transferase
S101359_RS17160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101359_RS17165	COG0110	maltose O-acetyltransferase activity
S101359_RS17170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S101359_RS17175	COG2244	polysaccharide biosynthetic process
S101359_RS17180	COG1216	Glycosyl transferase, family 2
S101359_RS17185	COG5039	Polysaccharide pyruvyl transferase
S101359_RS17190	COG1216	Glycosyl transferase, family 2
S101359_RS17200	COG0438	transferase activity, transferring glycosyl groups
S101359_RS17205	COG1215	transferase activity, transferring glycosyl groups
S101359_RS17210	COG0438	transferase activity, transferring glycosyl groups
S101359_RS17215	COG1086	Polysaccharide biosynthesis protein
S101359_RS17220	COG0489	protein tyrosine kinase activity
S101359_RS17225	COG1396	sequence-specific DNA binding
S101359_RS17230	COG2272	Belongs to the type-B carboxylesterase lipase family
S101359_RS17245	COG1131	(ABC) transporter
S101359_RS17265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S101359_RS17270	COG0583	DNA-binding transcription factor activity
S101359_RS17275	COG1621	beta-fructofuranosidase activity
S101359_RS17280	COG1621	beta-fructofuranosidase activity
S101359_RS17285	COG0531	amino acid
S101359_RS17290	COG1309	transcriptional regulator
S101359_RS17295	COG2076	Multidrug Resistance protein
S101359_RS17300	COG2076	Multidrug Resistance protein
S101359_RS17305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101359_RS17330	COG1611	Belongs to the LOG family
S101359_RS17335	COG1694	Mazg nucleotide pyrophosphohydrolase
S101359_RS17340	COG0659	secondary active sulfate transmembrane transporter activity
S101359_RS17345	COG0288	reversible hydration of carbon dioxide
S101359_RS17350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101359_RS17355	COG0577	efflux transmembrane transporter activity
S101359_RS17360	COG1136	(ABC) transporter
S101359_RS17365	COG5002	protein histidine kinase activity
S101359_RS17370	COG0745	RESPONSE REGULATOR receiver
S101359_RS17375	COG4290	ribonuclease
S101359_RS17380	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S101359_RS17385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101359_RS17395	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S101359_RS17400	COG1660	Displays ATPase and GTPase activities
S101359_RS17405	COG1051	belongs to the nudix hydrolase family
S101359_RS17410	COG0492	ferredoxin-NADP+ reductase activity
S101359_RS17415	COG3883	PFAM NLP P60 protein
S101359_RS17415	COG0791	NLP P60 protein
S101359_RS17420	COG0457	Tetratricopeptide repeat
S101359_RS17430	COG1132	(ABC) transporter
S101359_RS17440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S101359_RS17440	COG0140	phosphoribosyl-ATP diphosphatase activity
S101359_RS17445	COG0107	imidazoleglycerol-phosphate synthase activity
S101359_RS17450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S101359_RS17460	COG0131	Imidazoleglycerol-phosphate dehydratase
S101359_RS17465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S101359_RS17470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S101359_RS17475	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S101359_RS17480	COG4990	cell redox homeostasis
S101359_RS17485	COG5297	Belongs to the glycosyl hydrolase family 6
S101359_RS17490	COG0110	maltose O-acetyltransferase activity
S101359_RS17495	COG0546	phosphoglycolate phosphatase activity
S101359_RS17500	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
S101359_RS17505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S101359_RS17510	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S101359_RS17515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S101359_RS17525	COG2188	Transcriptional regulator
S101359_RS17530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S101359_RS17535	COG1950	PFAM Membrane protein of
S101359_RS17540	COG1983	PspC domain protein
S101359_RS17545	COG3595	metallopeptidase activity
S101359_RS17560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S101359_RS17570	COG4897	Protein conserved in bacteria
S101359_RS17575	COG3848	Pyruvate phosphate dikinase
S101359_RS17575	COG0574	Belongs to the PEP-utilizing enzyme family
S101359_RS17580	COG1309	transcriptional regulator
S101359_RS17585	COG2814	Major facilitator Superfamily
S101359_RS17600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101359_RS17610	COG0793	Belongs to the peptidase S41A family
S101359_RS17610	COG3409	Peptidoglycan-binding domain 1 protein
S101359_RS17615	COG2177	Part of the ABC transporter FtsEX involved in
S101359_RS17620	COG2884	Cell division ATP-binding protein ftsE
S101359_RS17625	COG2010	Cytochrome c
S101359_RS17630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101359_RS17640	COG0653	protein targeting
S101359_RS17645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S101359_RS17660	COG1516	flagellar protein fliS
S101359_RS17665	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S101359_RS17670	COG1334	flagellar protein FlaG
S101359_RS17675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101359_RS17680	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
S101359_RS17685	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
S101359_RS17695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101359_RS17700	COG4786	Flagellar basal body rod
S101359_RS17700	COG1256	bacterial-type flagellum assembly
S101359_RS17705	COG3418	PFAM FlgN family protein
S101359_RS17710	COG2747	anti-sigma28 factor FlgM
S101359_RS17720	COG1040	competence protein
S101359_RS17730	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S101359_RS17735	COG1307	EDD domain protein, DegV family
S101359_RS17740	COG2197	response regulator
S101359_RS17745	COG4585	Histidine kinase
S101359_RS17750	COG1739	Uncharacterized protein family UPF0029
S101359_RS17755	COG1316	TRANSCRIPTIONal
S101359_RS17760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101359_RS17765	COG0438	transferase activity, transferring glycosyl groups
S101359_RS17770	COG1215	transferase activity, transferring glycosyl groups
S101359_RS17775	COG3206	protein involved in exopolysaccharide biosynthesis
S101359_RS17780	COG3307	-O-antigen
S101359_RS17785	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101359_RS17790	COG0297	glycogen (starch) synthase activity
S101359_RS17790	COG0438	transferase activity, transferring glycosyl groups
S101359_RS17795	COG2244	polysaccharide biosynthetic process
S101359_RS17805	COG2247	cell wall binding repeat
S101359_RS17805	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101359_RS17810	COG2247	cell wall binding repeat
S101359_RS17810	COG2385	sporulation resulting in formation of a cellular spore
S101359_RS17820	COG1316	TRANSCRIPTIONal
S101359_RS17825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S101359_RS17830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S101359_RS17835	COG1134	teichoic acid transport
S101359_RS17840	COG1682	transport, permease protein
S101359_RS17845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101359_RS17850	COG0438	transferase activity, transferring glycosyl groups
S101359_RS17855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S101359_RS17860	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
S101359_RS17865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101359_RS17870	COG4193	domain, Protein
S101359_RS17875	COG1482	cell wall glycoprotein biosynthetic process
S101359_RS17885	COG0814	amino acid
S101359_RS17900	COG2814	Major facilitator Superfamily
S101359_RS17905	COG1316	TRANSCRIPTIONal
S101359_RS17910	COG0561	phosphatase activity
S101359_RS17915	COG0791	NLP P60 protein
S101359_RS17925	COG2843	Capsule synthesis protein
S101359_RS17935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S101359_RS17940	COG0697	spore germination
S101359_RS17945	COG0531	amino acid
S101359_RS17955	COG1609	Transcriptional regulator
S101359_RS17960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101359_RS17965	COG1869	D-ribose catabolic process
S101359_RS17970	COG1129	ABC transporter
S101359_RS17975	COG1172	Belongs to the binding-protein-dependent transport system permease family
S101359_RS17980	COG1879	ABC-type sugar transport system periplasmic component
S101359_RS17985	COG3103	Sh3 type 3 domain protein
S101359_RS17995	COG2249	NAD(P)H dehydrogenase (quinone) activity
S101359_RS18000	COG3527	Alpha-acetolactate decarboxylase
S101359_RS18005	COG0028	Belongs to the TPP enzyme family
S101359_RS18010	COG0583	DNA-binding transcription factor activity
S101359_RS18015	COG5337	Spore coat protein CotH
S101359_RS18025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S101359_RS18030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101359_RS18045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S101359_RS18055	COG0405	Gamma-glutamyltransferase
S101359_RS18060	COG1522	sequence-specific DNA binding
S101359_RS18065	COG2059	Chromate
S101359_RS18070	COG2059	Chromate
S101359_RS18080	COG0655	NAD(P)H dehydrogenase (quinone) activity
S101359_RS18085	COG0583	DNA-binding transcription factor activity
S101359_RS18105	COG5444	nuclease activity
S101359_RS18120	COG5444	nuclease activity
S101359_RS18140	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101359_RS18145	COG4464	protein tyrosine phosphatase activity
S101359_RS18150	COG0489	protein tyrosine kinase activity
S101359_RS18155	COG3944	biosynthesis protein
S101359_RS18165	COG4715	Zinc finger, swim domain protein
S101359_RS18170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S101359_RS18175	COG0561	phosphatase activity
S101359_RS18180	COG1349	DNA-binding transcription factor activity
S101359_RS18185	COG0629	single-stranded DNA binding
S101359_RS18200	COG3764	Sortase (surface protein transpeptidase)
S101359_RS18210	COG3279	Response regulator of the LytR AlgR family
S101359_RS18215	COG0745	RESPONSE REGULATOR receiver
S101359_RS18215	COG2972	Histidine kinase
S101359_RS18220	COG1970	mechanosensitive ion channel activity
S101359_RS18230	COG0457	Tetratricopeptide repeat
S101359_RS18235	COG4786	Flagellar basal body rod
S101359_RS18240	COG4786	Flagellar basal body rod
S101359_RS18245	COG1077	Cell shape determining protein MreB Mrl
S101359_RS18250	COG1609	Transcriptional regulator
S101359_RS18260	COG1846	Transcriptional regulator
S101359_RS18265	COG2814	Major facilitator Superfamily
S101359_RS18270	COG1953	Uracil, thiamine, allantoin
S101359_RS18275	COG0477	Major facilitator Superfamily
S101359_RS18280	COG1335	isochorismatase
S101359_RS18290	COG0004	ammonium transporteR
S101359_RS18295	COG0347	Belongs to the P(II) protein family
S101359_RS18300	COG0772	Belongs to the SEDS family
S101359_RS18305	COG0671	phosphoesterase, PA-phosphatase related
S101359_RS18315	COG0739	heme binding
S101359_RS18320	COG1247	-acetyltransferase
S101359_RS18330	COG1086	Polysaccharide biosynthesis protein
S101359_RS18335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101359_RS18340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101359_RS18345	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
S101359_RS18360	COG2089	acid synthase
S101359_RS18370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101359_RS18375	COG0789	Transcriptional regulator
S101359_RS18385	COG2910	NAD(P)H-binding
S101359_RS18390	COG1959	2 iron, 2 sulfur cluster binding
S101359_RS18395	COG0804	urea catabolic process
S101359_RS18405	COG0831	urea catabolic process
S101359_RS18415	COG3237	CsbD-like
S101359_RS18420	COG1994	Peptidase M50
S101359_RS18425	COG0457	Tetratricopeptide repeat
S101359_RS18435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S101359_RS18445	COG2304	oxidoreductase activity
S101359_RS18450	COG2304	oxidoreductase activity
S101359_RS18460	COG2385	sporulation resulting in formation of a cellular spore
S101359_RS18465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S101359_RS18475	COG4836	Membrane
S101359_RS18485	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S101359_RS18490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S101359_RS18495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S101359_RS18505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S101359_RS18510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S101359_RS18530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S101359_RS18535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S101359_RS18540	COG4475	Protein of unknown function (DUF436)
S101359_RS18545	COG0698	ribose 5-phosphate isomerase
S101359_RS18550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101359_RS18555	COG1971	Probably functions as a manganese efflux pump
S101359_RS18560	COG0009	L-threonylcarbamoyladenylate synthase
S101359_RS18565	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S101359_RS18585	COG2890	protein-(glutamine-N5) methyltransferase activity
S101359_RS18590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S101359_RS18595	COG0346	lactoylglutathione lyase activity
S101359_RS18600	COG0789	Transcriptional regulator
S101359_RS18605	COG0679	Auxin Efflux Carrier
S101359_RS18610	COG0281	malic enzyme
S101359_RS18620	COG0254	rRNA binding
S101359_RS18625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S101359_RS18630	COG1494	fructose-1,6-bisphosphatase
S101359_RS18635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S101359_RS18645	COG0191	fructose-bisphosphate aldolase activity
S101359_RS18650	COG2204	response regulator
S101359_RS18655	COG4821	SIS domain
S101359_RS18660	COG0504	CTP synthase activity
S101359_RS18665	COG3343	RNA polymerase activity
S101359_RS18670	COG1960	acyl-CoA dehydrogenase activity
S101359_RS18675	COG2181	nitrate reductase activity
S101359_RS18675	COG0247	lactate metabolic process
S101359_RS18680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101359_RS18685	COG4294	response to UV
S101359_RS18695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S101359_RS18700	COG1132	(ABC) transporter
S101359_RS18705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101359_RS18710	COG2181	nitrate reductase activity
S101359_RS18715	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
S101359_RS18720	COG1140	nitrate reductase beta subunit
S101359_RS18725	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
S101359_RS18730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S101359_RS18740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S101359_RS18745	COG2223	nitrite transmembrane transporter activity
S101359_RS18750	COG0018	arginyl-trna synthetase
S101359_RS18755	COG4506	Protein conserved in bacteria
S101359_RS18770	COG3391	amine dehydrogenase activity
S101359_RS18775	COG3391	amine dehydrogenase activity
S101359_RS18780	COG1388	LysM domain
S101359_RS18785	COG0457	Tetratricopeptide repeat
S101359_RS18815	COG1131	(ABC) transporter
S101359_RS18825	COG0010	Belongs to the arginase family
S101359_RS18830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S101359_RS18835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101359_RS18845	COG1994	Peptidase M50
S101359_RS18850	COG1942	4-Oxalocrotonate Tautomerase
S101359_RS18855	COG1846	Transcriptional regulator
S101359_RS18860	COG0531	amino acid
S101359_RS18865	COG3465	dGTPase activity
S101359_RS18870	COG1078	dGTPase activity
S101359_RS18875	COG4844	belongs to the
S101359_RS18885	COG0697	spore germination
S101359_RS18890	COG0095	Lipoate-protein ligase
S101359_RS18895	COG0583	DNA-binding transcription factor activity
S101359_RS18905	COG0280	phosphate acetyltransferase
S101359_RS18910	COG3253	May function as heme-dependent peroxidase
S101359_RS18915	COG2814	Major facilitator Superfamily
S101359_RS18920	COG2814	Major facilitator Superfamily
S101359_RS18930	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
S101359_RS18935	COG1091	dTDP-4-dehydrorhamnose reductase activity
S101359_RS18940	COG1088	dTDP-glucose 4,6-dehydratase activity
S101359_RS18945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
S101359_RS18950	COG0456	acetyltransferase
S101359_RS18955	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101359_RS18960	COG0463	Glycosyl transferase, family 2
S101359_RS18970	COG2363	Small membrane protein
S101359_RS18975	COG2233	PERMEase
S101359_RS18985	COG1012	belongs to the aldehyde dehydrogenase family
S101359_RS18990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S101359_RS18995	COG1216	Glycosyl transferase, family 2
S101359_RS19010	COG1695	Transcriptional regulator
S101359_RS19015	COG0351	phosphomethylpyrimidine kinase
S101359_RS19025	COG0110	maltose O-acetyltransferase activity
S101359_RS19030	COG1621	beta-fructofuranosidase activity
S101359_RS19035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101359_RS19035	COG1263	PTS System
S101359_RS19040	COG2116	formate transmembrane transporter activity
S101359_RS19045	COG3711	transcriptional antiterminator
S101359_RS19055	COG1404	Belongs to the peptidase S8 family
S101359_RS19070	COG0778	Nitroreductase
S101359_RS19075	COG0772	Belongs to the SEDS family
S101359_RS19090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S101359_RS19100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S101359_RS19105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S101359_RS19110	COG2261	transglycosylase associated protein
S101359_RS19115	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S101359_RS19120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S101359_RS19125	COG2246	polysaccharide biosynthetic process
S101359_RS19130	COG1309	transcriptional regulator
S101359_RS19150	COG3162	membrane
S101359_RS19155	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101359_RS19160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S101359_RS19165	COG0352	thiamine-phosphate diphosphorylase activity
S101359_RS19170	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S101359_RS19175	COG0583	DNA-binding transcription factor activity
S101359_RS19185	COG1346	cytolysis
S101359_RS19190	COG1131	(ABC) transporter
S101359_RS19215	COG1346	cytolysis
S101359_RS19220	COG4895	conserved protein (DUF2196)
S101359_RS19225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S101359_RS19230	COG0346	lactoylglutathione lyase activity
S101359_RS19235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101359_RS19245	COG1263	PTS System
S101359_RS19245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101359_RS19250	COG3711	transcriptional antiterminator
S101359_RS19255	COG1442	glycosyl transferase family 8
S101359_RS19260	COG5522	Integral membrane protein (intg_mem_TP0381)
S101359_RS19265	COG2234	aminopeptidase activity
S101359_RS19270	COG0457	Tetratricopeptide repeat
S101359_RS19275	COG1846	Transcriptional regulator
S101359_RS19280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S101359_RS19285	COG2357	RelA SpoT domain protein
S101359_RS19290	COG1575	Belongs to the MenA family. Type 1 subfamily
S101359_RS19295	COG0569	domain protein
S101359_RS19305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101359_RS19310	COG1696	Membrane protein involved in D-alanine export
S101359_RS19320	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S101359_RS19325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101359_RS19330	COG1486	melibiose metabolic process
S101359_RS19335	COG1447	Phosphotransferase system cellobiose-specific component IIA
S101359_RS19340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101359_RS19345	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101359_RS19350	COG3711	transcriptional antiterminator
S101359_RS19350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101359_RS19355	COG2094	Belongs to the DNA glycosylase MPG family
S101359_RS19360	COG0753	catalase activity
S101359_RS19365	COG2814	Major facilitator Superfamily
S101359_RS19370	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101359_RS19375	COG1131	(ABC) transporter
S101359_RS19395	COG1595	DNA-templated transcription, initiation
S101359_RS19400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S101359_RS19405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S101359_RS19410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S101359_RS19415	COG4988	ABC transporter
S101359_RS19420	COG1294	oxidase, subunit
S101359_RS19425	COG1271	oxidase subunit
S101359_RS19430	COG3493	citrate carrier protein
S101359_RS19440	COG0726	polysaccharide deacetylase
S101359_RS19445	COG3842	ATPase activity
S101359_RS19450	COG2508	Transcriptional regulator
S101359_RS19460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101359_RS19470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S101359_RS19475	COG1881	PFAM PEBP family protein
S101359_RS19490	COG2197	response regulator
S101359_RS19495	COG2195	Cleaves the N-terminal amino acid of tripeptides
S101359_RS19510	COG4894	glucomannan catabolic process
S101359_RS19515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101359_RS19520	COG3829	transcription factor binding
S101359_RS19520	COG3290	protein histidine kinase activity
S101359_RS19525	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS19530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S101359_RS19535	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S101359_RS19540	COG2610	gluconate transmembrane transporter activity
S101359_RS19545	COG0500	methyltransferase
S101359_RS19550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101359_RS19565	COG0753	catalase activity
S101359_RS19565	COG0693	protein deglycase activity
S101359_RS19570	COG2851	Citrate transporter
S101359_RS19580	COG3711	transcriptional antiterminator
S101359_RS19590	COG2270	Major facilitator Superfamily
S101359_RS19595	COG0513	Belongs to the DEAD box helicase family
S101359_RS19600	COG0346	lactoylglutathione lyase activity
S101359_RS19605	COG1357	PFAM Pentapeptide repeats (8 copies)
S101359_RS19610	COG2755	lipolytic protein G-D-S-L family
S101359_RS19610	COG3401	FG-GAP repeat protein
S101359_RS19700	COG3209	COG3209 Rhs family protein
S101359_RS19705	COG3866	Pectate lyase
S101359_RS19710	COG0697	spore germination
S101359_RS19715	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS19740	COG0589	response to stress
S101359_RS19745	COG2723	6-phospho-beta-galactosidase activity
S101359_RS19750	COG2190	(PTS) system
S101359_RS19750	COG1263	PTS System
S101359_RS19750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101359_RS19755	COG3977	Valine--pyruvate aminotransferase
S101359_RS19770	COG1181	Belongs to the D-alanine--D-alanine ligase family
S101359_RS19780	COG3507	Belongs to the glycosyl hydrolase 43 family
S101359_RS19840	COG2986	histidine ammonia-lyase
S101359_RS19845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
S101359_RS19850	COG1228	amidohydrolase
S101359_RS19855	COG0010	Belongs to the arginase family
S101359_RS19860	COG0833	amino acid
S101359_RS19865	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S101359_RS19870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101359_RS19875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S101359_RS19880	COG2390	Transcriptional regulator
S101359_RS19890	COG3192	ethanolamine utilization protein
S101359_RS19895	COG1940	carbohydrate kinase activity
S101359_RS19900	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S101359_RS19905	COG0561	phosphatase activity
S101359_RS19930	COG5294	Protein conserved in bacteria
S101359_RS19935	COG0577	efflux transmembrane transporter activity
S101359_RS19940	COG1136	(ABC) transporter
S101359_RS19945	COG2205	protein histidine kinase activity
S101359_RS19950	COG0745	RESPONSE REGULATOR receiver
S101359_RS19960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101359_RS19975	COG1082	Xylose isomerase domain protein TIM barrel
S101359_RS19980	COG0673	inositol 2-dehydrogenase activity
S101359_RS19985	COG2814	Major facilitator Superfamily
S101359_RS19990	COG1082	Xylose isomerase domain protein TIM barrel
S101359_RS19995	COG3962	Belongs to the TPP enzyme family
S101359_RS20000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101359_RS20015	COG1349	DNA-binding transcription factor activity
S101359_RS20020	COG0667	Aldo Keto reductase
S101359_RS20040	COG2814	Major facilitator Superfamily
S101359_RS20045	COG0326	Molecular chaperone. Has ATPase activity
S101359_RS20055	COG1028	Short-chain dehydrogenase reductase Sdr
S101359_RS20060	COG1309	transcriptional regulator
S101359_RS20065	COG1012	belongs to the aldehyde dehydrogenase family
S101359_RS20075	COG1714	RDD family
S101359_RS20080	COG2311	Membrane
S101359_RS20085	COG1917	Cupin 2, conserved barrel domain protein
S101359_RS20090	COG1309	transcriptional regulator
S101359_RS20125	COG5039	Polysaccharide pyruvyl transferase
S101359_RS20130	COG1929	Belongs to the glycerate kinase type-1 family
S101359_RS20135	COG2610	gluconate transmembrane transporter activity
S101359_RS20140	COG3835	regulator
S101359_RS20145	COG1802	Transcriptional regulator
S101359_RS20150	COG1070	Carbohydrate kinase
S101359_RS20155	COG2610	gluconate transmembrane transporter activity
S101359_RS20160	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S101359_RS20170	COG0450	alkyl hydroperoxide reductase
S101359_RS20175	COG3634	alkyl hydroperoxide reductase activity
S101359_RS20185	COG1113	amino acid transport
S101359_RS20200	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
S101359_RS20210	COG2323	membrane
S101359_RS20220	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
S101359_RS20240	COG1192	Involved in chromosome partitioning
S101359_RS20245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S101359_RS20255	COG1063	alcohol dehydrogenase
S101359_RS20270	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
S101359_RS20275	COG0456	acetyltransferase
S101359_RS20280	COG0010	Belongs to the arginase family
S101359_RS20285	COG0833	amino acid
S101359_RS20290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S101359_RS20295	COG5658	integral membrane protein
S101359_RS20300	COG0640	Transcriptional regulator
S101359_RS20305	COG3829	transcription factor binding
S101359_RS20315	COG0488	(ABC) transporter
S101359_RS20330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S101359_RS20340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101359_RS20345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S101359_RS20350	COG4853	Protein conserved in bacteria
S101359_RS20355	COG4863	YycH protein
S101359_RS20360	COG5002	protein histidine kinase activity
S101359_RS20365	COG0745	RESPONSE REGULATOR receiver
S101359_RS20395	COG0346	lactoylglutathione lyase activity
S101359_RS20400	COG0305	Participates in initiation and elongation during chromosome replication
S101359_RS20415	COG3093	addiction module antidote protein HigA
S101359_RS20420	COG2807	transmembrane transport
S101359_RS20425	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S101359_RS20430	COG0359	binds to the 23S rRNA
S101359_RS20435	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
S101359_RS20440	COG4241	membrane
S101359_RS20450	COG5577	PFAM Coat F domain
S101359_RS20455	COG1733	regulation of RNA biosynthetic process
S101359_RS20470	COG2271	Major facilitator Superfamily
S101359_RS20475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101359_RS20495	COG5444	nuclease activity
S101359_RS20515	COG0473	3-isopropylmalate dehydrogenase activity
S101359_RS20520	COG1802	Transcriptional regulator
S101359_RS20525	COG4978	Transcriptional regulator
S101359_RS20525	COG0789	Transcriptional regulator
S101359_RS20535	COG2409	Drug exporters of the RND superfamily
S101359_RS20540	COG2197	response regulator
S101359_RS20545	COG4585	Histidine kinase
S101359_RS20565	COG0745	RESPONSE REGULATOR receiver
S101359_RS20570	COG2205	protein histidine kinase activity
S101359_RS20595	COG1331	Highly conserved protein containing a thioredoxin domain
S101359_RS20600	COG0477	Major facilitator Superfamily
S101359_RS20600	COG2814	Major facilitator Superfamily
S101359_RS20605	COG0346	lactoylglutathione lyase activity
S101359_RS20610	COG1609	Transcriptional regulator
S101359_RS20615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S101359_RS20620	COG2169	Transcriptional regulator
S101359_RS20625	COG0708	Exodeoxyribonuclease III
S101359_RS20630	COG0697	spore germination
S101359_RS20635	COG1802	Transcriptional regulator
S101359_RS20650	COG0629	single-stranded DNA binding
S101359_RS20655	COG0360	Binds together with S18 to 16S ribosomal RNA
S101359_RS20660	COG0012	GTP binding
S101359_RS20670	COG4481	Protein conserved in bacteria
S101359_RS20675	COG3949	Membrane
S101359_RS20680	COG0457	Tetratricopeptide repeat
S101359_RS20700	COG0741	lytic transglycosylase activity
S101359_RS20700	COG0791	NLP P60 protein
S101359_RS20705	COG5644	endopeptidase inhibitor activity
S101359_RS20715	COG0433	COG0433 Predicted ATPase
S101359_RS20735	COG0346	lactoylglutathione lyase activity
S101359_RS20750	COG2946	Replication initiation factor
S101359_RS20755	COG1674	ftsk spoiiie
S101359_RS20775	COG1396	sequence-specific DNA binding
S101359_RS20780	COG2856	Zn peptidase
S101359_RS20785	COG0582	viral genome integration into host DNA
S101359_RS20795	COG1475	DNA binding
S101359_RS20800	COG1192	Involved in chromosome partitioning
S101359_RS20810	COG1475	DNA binding
S101359_RS20815	COG0357	Ribosomal RNA small subunit methyltransferase G
S101359_RS20820	COG0445	tRNA wobble uridine modification
S101359_RS20830	COG1847	R3H domain protein
S101359_RS20835	COG0706	membrane insertase activity
S101359_RS20840	COG0594	ribonuclease P activity