locus-tag	class	description
CWI35_RS00010	COG0789	Transcriptional regulator
CWI35_RS00015	COG1664	Polymer-forming cytoskeletal
CWI35_RS00035	COG3858	chitin binding
CWI35_RS00035	COG1388	LysM domain
CWI35_RS00040	COG2210	Belongs to the sulfur carrier protein TusA family
CWI35_RS00050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_RS00050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_RS00055	COG2226	methyltransferase
CWI35_RS00065	COG1937	Protein conserved in bacteria
CWI35_RS00070	COG0425	Belongs to the sulfur carrier protein TusA family
CWI35_RS00075	COG2210	Belongs to the sulfur carrier protein TusA family
CWI35_RS00085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_RS00090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_RS00090	COG0425	Belongs to the sulfur carrier protein TusA family
CWI35_RS00095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_RS00095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_RS00100	COG0730	response to heat
CWI35_RS00125	COG0561	phosphatase activity
CWI35_RS00135	COG0710	3-dehydroquinate dehydratase activity
CWI35_RS00140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CWI35_RS00155	COG0463	Glycosyl transferase, family 2
CWI35_RS00160	COG2246	polysaccharide biosynthetic process
CWI35_RS00170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CWI35_RS00175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CWI35_RS00190	COG0129	dihydroxy-acid dehydratase activity
CWI35_RS00195	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CWI35_RS00200	COG3396	Phenylacetate-CoA oxygenase
CWI35_RS00215	COG2151	metal-sulfur cluster biosynthetic enzyme
CWI35_RS00225	COG1024	Enoyl-CoA hydratase
CWI35_RS00230	COG1024	Enoyl-CoA hydratase
CWI35_RS00235	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_RS00240	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWI35_RS00245	COG0183	Belongs to the thiolase family
CWI35_RS00250	COG3327	negative regulation of DNA-templated transcription, initiation
CWI35_RS00275	COG4120	Belongs to the binding-protein-dependent transport system permease family
CWI35_RS00280	COG3842	ATPase activity
CWI35_RS00290	COG0022	dehydrogenase e1 component
CWI35_RS00310	COG3104	oligopeptide transport
CWI35_RS00315	COG3842	ATPase activity
CWI35_RS00320	COG1175	transmembrane transport
CWI35_RS00335	COG2186	Transcriptional regulator
CWI35_RS00340	COG0277	FAD linked oxidase domain protein
CWI35_RS00345	COG0247	lactate metabolic process
CWI35_RS00350	COG1840	ABC-type Fe3 transport system, periplasmic component
CWI35_RS00355	COG3842	ATPase activity
CWI35_RS00360	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWI35_RS00370	COG0579	oxidoreductase
CWI35_RS00380	COG2843	Capsule synthesis protein
CWI35_RS00400	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_RS00425	COG2151	metal-sulfur cluster biosynthetic enzyme
CWI35_RS00440	COG1024	Enoyl-CoA hydratase
CWI35_RS00460	COG0385	Bile acid
CWI35_RS00480	COG2154	pterin-4-alpha-carbinolamine dehydratase
CWI35_RS00495	COG0784	Response regulator, receiver
CWI35_RS00500	COG4191	Histidine kinase
CWI35_RS00505	COG0765	amino acid transport
CWI35_RS00510	COG0765	amino acid transport
CWI35_RS00525	COG0667	Aldo Keto reductase
CWI35_RS00545	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_RS00570	COG3711	transcriptional antiterminator
CWI35_RS00580	COG0246	Mannitol dehydrogenase
CWI35_RS00610	COG3290	protein histidine kinase activity
CWI35_RS00615	COG4565	transcriptional regulatory protein
CWI35_RS00620	COG0679	Auxin Efflux Carrier
CWI35_RS00625	COG1609	Transcriptional regulator
CWI35_RS00640	COG0840	transmembrane signaling receptor activity
CWI35_RS00660	COG0411	ABC transporter
CWI35_RS00670	COG0831	urea catabolic process
CWI35_RS00675	COG0832	Belongs to the urease beta subunit family
CWI35_RS00680	COG0804	urea catabolic process
CWI35_RS00685	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CWI35_RS00690	COG0830	nickel cation binding
CWI35_RS00710	COG0456	acetyltransferase
CWI35_RS00735	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CWI35_RS00740	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_RS00745	COG1024	Enoyl-CoA hydratase
CWI35_RS00750	COG2376	Dihydroxyacetone kinase
CWI35_RS00800	COG1070	Carbohydrate kinase
CWI35_RS00815	COG3829	transcription factor binding
CWI35_RS00815	COG3290	protein histidine kinase activity
CWI35_RS00825	COG1454	alcohol dehydrogenase
CWI35_RS00835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWI35_RS00840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CWI35_RS00845	COG2146	nitrite reductase [NAD(P)H] activity
CWI35_RS00850	COG0243	molybdopterin cofactor binding
CWI35_RS00855	COG2223	nitrite transmembrane transporter activity
CWI35_RS00860	COG1846	Transcriptional regulator
CWI35_RS00870	COG0789	Transcriptional regulator
CWI35_RS00875	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWI35_RS00880	COG1447	Phosphotransferase system cellobiose-specific component IIA
CWI35_RS00885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CWI35_RS00890	COG2723	6-phospho-beta-galactosidase activity
CWI35_RS00895	COG2188	Transcriptional regulator
CWI35_RS00905	COG0726	polysaccharide deacetylase
CWI35_RS00910	COG1408	metallophosphoesterase
CWI35_RS00915	COG1757	Na H antiporter
CWI35_RS00925	COG0385	Bile acid
CWI35_RS00965	COG2199	diguanylate cyclase activity
CWI35_RS00965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CWI35_RS00975	COG1349	DNA-binding transcription factor activity
CWI35_RS00980	COG1105	Belongs to the carbohydrate kinase PfkB family
CWI35_RS00985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWI35_RS00985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWI35_RS00985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWI35_RS00990	COG0701	Predicted permease
CWI35_RS00995	COG3689	TIGRFAM TIGR03943 family protein
CWI35_RS01005	COG0432	Pfam Uncharacterised protein family UPF0047
CWI35_RS01010	COG0024	Methionine aminopeptidase
CWI35_RS01015	COG5002	protein histidine kinase activity
CWI35_RS01030	COG1587	Uroporphyrinogen-III synthase
CWI35_RS01040	COG2181	nitrate reductase activity
CWI35_RS01045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CWI35_RS01050	COG1140	nitrate reductase beta subunit
CWI35_RS01055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CWI35_RS01080	COG0706	membrane insertase activity
CWI35_RS01090	COG1335	isochorismatase
CWI35_RS01095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CWI35_RS01100	COG1164	Oligoendopeptidase f
CWI35_RS01105	COG4989	oxidoreductase activity
CWI35_RS01110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWI35_RS01120	COG0584	glycerophosphoryl diester phosphodiesterase
CWI35_RS01180	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CWI35_RS01210	COG1492	cobalamin metabolic process
CWI35_RS01215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CWI35_RS01245	COG0386	Belongs to the glutathione peroxidase family
CWI35_RS01250	COG1413	lyase activity
CWI35_RS01275	COG0494	nUDIX hydrolase
CWI35_RS01290	COG0436	Aminotransferase
CWI35_RS01305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CWI35_RS01310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CWI35_RS01320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWI35_RS01335	COG1999	signal sequence binding
CWI35_RS01340	COG2755	lipolytic protein G-D-S-L family
CWI35_RS01350	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CWI35_RS01350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWI35_RS01355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CWI35_RS01385	COG1525	nuclease
CWI35_RS01385	COG4085	toxin activity
CWI35_RS01385	COG0737	Belongs to the 5'-nucleotidase family
CWI35_RS01390	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWI35_RS01400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CWI35_RS01405	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CWI35_RS01430	COG3647	Membrane
CWI35_RS01475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_RS01485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CWI35_RS01495	COG1832	CoA-binding protein
CWI35_RS01500	COG0187	DNA topoisomerase II activity
CWI35_RS01505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWI35_RS01520	COG1263	PTS System
CWI35_RS01520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWI35_RS01525	COG0366	Alpha amylase catalytic
CWI35_RS01530	COG2188	Transcriptional regulator
CWI35_RS01535	COG1757	Na H antiporter
CWI35_RS01545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWI35_RS01545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWI35_RS01550	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS01555	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CWI35_RS01560	COG1959	2 iron, 2 sulfur cluster binding
CWI35_RS01565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CWI35_RS01565	COG1017	nitric oxide dioxygenase activity
CWI35_RS01570	COG0788	formyltetrahydrofolate deformylase activity
CWI35_RS01580	COG0714	Associated with various cellular activities
CWI35_RS01585	COG4548	von Willebrand factor, type A
CWI35_RS01590	COG2404	hydrolase activity, acting on ester bonds
CWI35_RS01635	COG1279	arginine transmembrane transporter activity
CWI35_RS01645	COG3402	PFAM membrane-flanked domain
CWI35_RS01650	COG1113	amino acid transport
CWI35_RS01660	COG1388	LysM domain
CWI35_RS01670	COG0745	RESPONSE REGULATOR receiver
CWI35_RS01675	COG5002	protein histidine kinase activity
CWI35_RS01680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWI35_RS01680	COG0551	DNA topoisomerase type I activity
CWI35_RS01690	COG0515	serine threonine protein kinase
CWI35_RS01695	COG1024	Enoyl-CoA hydratase
CWI35_RS01705	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_RS01730	COG1119	ATPase activity
CWI35_RS01735	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CWI35_RS01770	COG0697	spore germination
CWI35_RS01800	COG0559	Belongs to the binding-protein-dependent transport system permease family
CWI35_RS01810	COG0183	Belongs to the thiolase family
CWI35_RS01820	COG2030	dehydratase
CWI35_RS01830	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS01835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CWI35_RS01840	COG0778	Nitroreductase
CWI35_RS01845	COG1741	Belongs to the pirin family
CWI35_RS01855	COG2337	Toxic component of a toxin-antitoxin (TA) module
CWI35_RS01900	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CWI35_RS01905	COG1131	(ABC) transporter
CWI35_RS01925	COG0730	response to heat
CWI35_RS01950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWI35_RS01955	COG2258	MOSC domain
CWI35_RS01960	COG1132	(ABC) transporter
CWI35_RS01965	COG1132	(ABC) transporter
CWI35_RS01990	COG2208	phosphoserine phosphatase activity
CWI35_RS01995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CWI35_RS02005	COG0697	spore germination
CWI35_RS02020	COG1131	(ABC) transporter
CWI35_RS02025	COG1725	Transcriptional regulator
CWI35_RS02050	COG2223	nitrite transmembrane transporter activity
CWI35_RS02055	COG2205	protein histidine kinase activity
CWI35_RS02105	COG2814	Major facilitator Superfamily
CWI35_RS02110	COG1566	PFAM secretion protein HlyD family protein
CWI35_RS02115	COG1846	Transcriptional regulator
CWI35_RS02125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CWI35_RS02130	COG1024	Enoyl-CoA hydratase
CWI35_RS02135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWI35_RS02140	COG0511	ligase activity, forming carbon-carbon bonds
CWI35_RS02145	COG0439	Biotin carboxylase
CWI35_RS02150	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_RS02155	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS02160	COG1309	transcriptional regulator
CWI35_RS02185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWI35_RS02195	COG3852	Histidine kinase
CWI35_RS02200	COG0534	Mate efflux family protein
CWI35_RS02220	COG2962	Rard protein
CWI35_RS02230	COG0598	Magnesium transport protein CorA
CWI35_RS02235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWI35_RS02240	COG2226	methyltransferase
CWI35_RS02245	COG1876	peptidase activity
CWI35_RS02250	COG0813	purine-nucleoside phosphorylase activity
CWI35_RS02290	COG4479	Belongs to the UPF0346 family
CWI35_RS02295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CWI35_RS02315	COG4841	protein insertion into membrane
CWI35_RS02320	COG2050	protein possibly involved in aromatic compounds catabolism
CWI35_RS02330	COG0824	Thioesterase
CWI35_RS02350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWI35_RS02370	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CWI35_RS02375	COG1755	Isoprenylcysteine carboxyl methyltransferase
CWI35_RS02380	COG3424	synthase
CWI35_RS02390	COG2233	PERMEase
CWI35_RS02395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWI35_RS02405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CWI35_RS02410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CWI35_RS02415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CWI35_RS02420	COG1199	ATP-dependent helicase activity
CWI35_RS02425	COG0116	Belongs to the methyltransferase superfamily
CWI35_RS02435	COG3599	regulation of cell shape
CWI35_RS02455	COG3359	exonuclease
CWI35_RS02460	COG1111	helicase
CWI35_RS02460	COG1205	dead DEAH box helicase
CWI35_RS02465	COG1414	Transcriptional regulator
CWI35_RS02470	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWI35_RS02475	COG0281	malic enzyme
CWI35_RS02480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CWI35_RS02485	COG0277	FAD linked oxidase domain protein
CWI35_RS02490	COG0247	lactate metabolic process
CWI35_RS02495	COG0277	FAD linked oxidase domain protein
CWI35_RS02505	COG3622	Belongs to the hyi family
CWI35_RS02510	COG0670	Belongs to the BI1 family
CWI35_RS02530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CWI35_RS02540	COG5002	protein histidine kinase activity
CWI35_RS02560	COG5577	PFAM Coat F domain
CWI35_RS02570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWI35_RS02575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWI35_RS02600	COG3594	Acyltransferase
CWI35_RS02605	COG0352	thiamine-phosphate diphosphorylase activity
CWI35_RS02610	COG0351	phosphomethylpyrimidine kinase
CWI35_RS02615	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CWI35_RS02620	COG0463	Glycosyl transferase, family 2
CWI35_RS02640	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_RS02655	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CWI35_RS02660	COG1984	allophanate hydrolase subunit 2
CWI35_RS02665	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CWI35_RS02670	COG1414	Transcriptional regulator
CWI35_RS02680	COG0456	acetyltransferase
CWI35_RS02685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CWI35_RS02685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CWI35_RS02705	COG2135	peptidase activity
CWI35_RS02715	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS02720	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_RS02745	COG4555	ABC transporter
CWI35_RS02755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWI35_RS02765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CWI35_RS02770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CWI35_RS02775	COG3279	Response regulator of the LytR AlgR family
CWI35_RS02795	COG1366	Belongs to the anti-sigma-factor antagonist family
CWI35_RS02810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWI35_RS02835	COG2200	EAL domain
CWI35_RS02850	COG0406	alpha-ribazole phosphatase activity
CWI35_RS02880	COG1120	ATPase activity
CWI35_RS02885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWI35_RS02890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWI35_RS02925	COG0004	ammonium transporteR
CWI35_RS02945	COG3853	Toxic anion resistance protein (TelA)
CWI35_RS03005	COG2340	Cysteine-rich secretory protein family
CWI35_RS03015	COG4821	SIS domain
CWI35_RS03035	COG0697	spore germination
CWI35_RS03045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CWI35_RS03065	COG0671	phosphoesterase, PA-phosphatase related
CWI35_RS03070	COG0493	'glutamate synthase
CWI35_RS03075	COG0070	glutamate synthase
CWI35_RS03075	COG0069	glutamate synthase activity
CWI35_RS03075	COG0067	glutamate synthase
CWI35_RS03080	COG0583	DNA-binding transcription factor activity
CWI35_RS03085	COG0604	alcohol dehydrogenase
CWI35_RS03095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CWI35_RS03100	COG2508	Transcriptional regulator
CWI35_RS03105	COG1113	amino acid transport
CWI35_RS03145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CWI35_RS03150	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CWI35_RS03155	COG0583	DNA-binding transcription factor activity
CWI35_RS03165	COG0640	Transcriptional regulator
CWI35_RS03170	COG0393	Putative heavy-metal-binding
CWI35_RS03190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_RS03195	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CWI35_RS03200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWI35_RS03205	COG5582	Belongs to the UPF0302 family
CWI35_RS03210	COG0579	oxidoreductase
CWI35_RS03270	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CWI35_RS03275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWI35_RS03315	COG3384	dioxygenase
CWI35_RS03320	COG0653	protein targeting
CWI35_RS03330	COG2313	pseudouridylate synthase activity
CWI35_RS03345	COG2391	methyltransferase activity
CWI35_RS03350	COG1970	mechanosensitive ion channel activity
CWI35_RS03355	COG3314	Sporulation integral membrane protein YlbJ
CWI35_RS03360	COG1228	amidohydrolase
CWI35_RS03365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CWI35_RS03370	COG1917	Cupin 2, conserved barrel domain protein
CWI35_RS03370	COG4977	sequence-specific DNA binding
CWI35_RS03375	COG0010	Belongs to the arginase family
CWI35_RS03390	COG0346	lactoylglutathione lyase activity
CWI35_RS03410	COG0601	transmembrane transport
CWI35_RS03415	COG4608	Belongs to the ABC transporter superfamily
CWI35_RS03435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CWI35_RS03475	COG0328	RNA-DNA hybrid ribonuclease activity
CWI35_RS03490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CWI35_RS03515	COG1388	LysM domain
CWI35_RS03515	COG1705	Flagellar rod assembly protein muramidase FlgJ
CWI35_RS03525	COG4846	Membrane protein involved in cytochrome C biogenesis
CWI35_RS03530	COG2201	protein-glutamate methylesterase activity
CWI35_RS03535	COG0785	Cytochrome C biogenesis protein
CWI35_RS03545	COG1132	(ABC) transporter
CWI35_RS03550	COG1132	(ABC) transporter
CWI35_RS03555	COG3763	UPF0154 protein
CWI35_RS03570	COG4224	UPF0291 protein
CWI35_RS03580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CWI35_RS03585	COG1388	LysM domain
CWI35_RS03590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CWI35_RS03595	COG0174	glutamine synthetase
CWI35_RS03600	COG0789	Transcriptional regulator
CWI35_RS03605	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CWI35_RS03610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWI35_RS03615	COG2860	membrane
CWI35_RS03620	COG0697	spore germination
CWI35_RS03630	COG0183	Belongs to the thiolase family
CWI35_RS03635	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWI35_RS03640	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_RS03645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWI35_RS03650	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS03660	COG0464	growth
CWI35_RS03665	COG1923	regulation of RNA biosynthetic process
CWI35_RS03670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CWI35_RS03675	COG0840	transmembrane signaling receptor activity
CWI35_RS03680	COG0477	Major facilitator Superfamily
CWI35_RS03695	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CWI35_RS03700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CWI35_RS03715	COG4550	Control of competence regulator ComK, YlbF/YmcA
CWI35_RS03720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWI35_RS03725	COG1013	pyruvate-flavodoxin oxidoreductase activity
CWI35_RS03730	COG0674	pyruvate-flavodoxin oxidoreductase activity
CWI35_RS03730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CWI35_RS03740	COG2359	stage V sporulation protein S
CWI35_RS03745	COG1692	metallophosphoesterase
CWI35_RS03750	COG1418	mRNA catabolic process
CWI35_RS03775	COG1546	Belongs to the CinA family
CWI35_RS03775	COG1058	Belongs to the CinA family
CWI35_RS03780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CWI35_RS03785	COG1426	Protein conserved in bacteria
CWI35_RS03800	COG0300	oxidoreductase activity
CWI35_RS03805	COG0612	Peptidase, M16
CWI35_RS03810	COG0612	Peptidase, M16
CWI35_RS03815	COG1079	Belongs to the binding-protein-dependent transport system permease family
CWI35_RS03820	COG4603	Belongs to the binding-protein-dependent transport system permease family
CWI35_RS03825	COG3845	ABC transporter
CWI35_RS03835	COG1744	ABC transporter substrate-binding protein PnrA-like
CWI35_RS03840	COG2188	Transcriptional regulator
CWI35_RS03845	COG4980	gas vesicle protein
CWI35_RS03845	COG1674	ftsk spoiiie
CWI35_RS03860	COG0740	serine-type endopeptidase activity
CWI35_RS03865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CWI35_RS03875	COG0527	aspartate kinase activity
CWI35_RS03880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CWI35_RS03885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CWI35_RS03890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWI35_RS03895	COG1873	PFAM PRC-barrel domain
CWI35_RS03900	COG0612	Peptidase, M16
CWI35_RS03905	COG0726	polysaccharide deacetylase
CWI35_RS03910	COG1185	polyribonucleotide nucleotidyltransferase activity
CWI35_RS03915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CWI35_RS03920	COG0196	riboflavin kinase activity
CWI35_RS03925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CWI35_RS03930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CWI35_RS03935	COG1550	Protein conserved in bacteria
CWI35_RS03945	COG1358	cellular component organization or biogenesis
CWI35_RS03950	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CWI35_RS03955	COG0195	Participates in both transcription termination and antitermination
CWI35_RS03960	COG0779	Required for maturation of 30S ribosomal subunits
CWI35_RS03965	COG2176	DNA-directed DNA polymerase activity
CWI35_RS03970	COG0442	prolyl-tRNA aminoacylation
CWI35_RS03975	COG0750	zinc metalloprotease
CWI35_RS03980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CWI35_RS03985	COG4589	Belongs to the CDS family
CWI35_RS03990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWI35_RS03995	COG0233	cytoplasmic translational termination
CWI35_RS04000	COG0528	UMP kinase activity
CWI35_RS04005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CWI35_RS04010	COG0052	Belongs to the universal ribosomal protein uS2 family
CWI35_RS04025	COG1191	sigma factor activity
CWI35_RS04030	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CWI35_RS04035	COG1776	CheC inhibitor of MCP methylation
CWI35_RS04040	COG0835	chemotaxis
CWI35_RS04045	COG0643	Histidine kinase
CWI35_RS04045	COG2198	Histidine kinase
CWI35_RS04050	COG2201	protein-glutamate methylesterase activity
CWI35_RS04055	COG0455	bacterial-type flagellum organization
CWI35_RS04060	COG1419	protein localization to endoplasmic reticulum
CWI35_RS04065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CWI35_RS04070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CWI35_RS04095	COG1987	bacterial-type flagellum assembly
CWI35_RS04100	COG1338	Plays a role in the flagellum-specific transport system
CWI35_RS04105	COG3190	flagellar
CWI35_RS04110	COG2201	protein-glutamate methylesterase activity
CWI35_RS04115	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CWI35_RS04115	COG1776	CheC inhibitor of MCP methylation
CWI35_RS04120	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CWI35_RS04130	COG1582	Flagellar protein (FlbD)
CWI35_RS04135	COG4786	Flagellar basal body rod
CWI35_RS04140	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CWI35_RS04145	COG3144	bacterial-type flagellum assembly
CWI35_RS04155	COG2882	bacterial-type flagellum organization
CWI35_RS04160	COG1157	protein secretion by the type III secretion system
CWI35_RS04165	COG1317	bacterial-type flagellum organization
CWI35_RS04170	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CWI35_RS04175	COG1766	The M ring may be actively involved in energy transduction
CWI35_RS04180	COG1677	Flagellar hook-basal body complex protein FliE
CWI35_RS04190	COG1815	bacterial-type flagellum-dependent cell motility
CWI35_RS04195	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CWI35_RS04200	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CWI35_RS04205	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CWI35_RS04210	COG4974	Belongs to the 'phage' integrase family
CWI35_RS04215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWI35_RS04220	COG0758	DNA mediated transformation
CWI35_RS04225	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CWI35_RS04230	COG0045	succinate-CoA ligase (ADP-forming) activity
CWI35_RS04235	COG2257	FlhB HrpN YscU SpaS Family
CWI35_RS04245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWI35_RS04250	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CWI35_RS04265	COG0336	Belongs to the RNA methyltransferase TrmD family
CWI35_RS04270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CWI35_RS04280	COG1837	Belongs to the UPF0109 family
CWI35_RS04285	COG0228	four-way junction DNA binding
CWI35_RS04290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CWI35_RS04295	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CWI35_RS04300	COG0552	protein localization to endoplasmic reticulum
CWI35_RS04305	COG1196	nuclear chromosome segregation
CWI35_RS04315	COG0571	ribonuclease III activity
CWI35_RS04320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWI35_RS04325	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_RS04330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CWI35_RS04335	COG0416	fatty acid biosynthetic process
CWI35_RS04340	COG1349	DNA-binding transcription factor activity
CWI35_RS04340	COG2050	protein possibly involved in aromatic compounds catabolism
CWI35_RS04345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CWI35_RS04350	COG1760	l-serine dehydratase
CWI35_RS04355	COG1760	l-serine dehydratase
CWI35_RS04360	COG1461	Dihydroxyacetone kinase
CWI35_RS04365	COG1302	Protein conserved in bacteria
CWI35_RS04370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWI35_RS04380	COG1564	THIamine pyrophosphokinase
CWI35_RS04385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWI35_RS04390	COG1162	GTPase activity
CWI35_RS04395	COG2815	serine threonine protein kinase
CWI35_RS04395	COG0515	serine threonine protein kinase
CWI35_RS04400	COG0631	protein serine/threonine phosphatase activity
CWI35_RS04405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CWI35_RS04410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWI35_RS04410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWI35_RS04415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWI35_RS04420	COG0242	peptide deformylase activity
CWI35_RS04425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CWI35_RS04430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CWI35_RS04435	COG1758	RNA polymerase activity
CWI35_RS04440	COG0194	GDP metabolic process
CWI35_RS04445	COG2052	Domain of unknown function (DUF370)
CWI35_RS04450	COG1561	YicC-like family, N-terminal region
CWI35_RS04455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CWI35_RS04490	COG0284	orotidine-5'-phosphate decarboxylase activity
CWI35_RS04495	COG0167	dihydroorotate dehydrogenase activity
CWI35_RS04515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CWI35_RS04520	COG0540	Belongs to the ATCase OTCase family
CWI35_RS04535	COG0564	pseudouridine synthase activity
CWI35_RS04540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CWI35_RS04545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CWI35_RS04550	COG3599	regulation of cell shape
CWI35_RS04555	COG2302	S4 RNA-binding domain
CWI35_RS04560	COG0762	integral membrane protein
CWI35_RS04565	COG1799	cell septum assembly
CWI35_RS04570	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CWI35_RS04580	COG1873	PFAM PRC-barrel domain
CWI35_RS04585	COG1191	sigma factor activity
CWI35_RS04590	COG1191	sigma factor activity
CWI35_RS04600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CWI35_RS04605	COG0849	cell division
CWI35_RS04610	COG3856	small basic protein
CWI35_RS04615	COG3879	Bacterial protein of unknown function (DUF881)
CWI35_RS04620	COG3879	Bacterial protein of unknown function (DUF881)
CWI35_RS04625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CWI35_RS04630	COG0772	Belongs to the SEDS family
CWI35_RS04635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CWI35_RS04640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWI35_RS04650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWI35_RS04655	COG0768	penicillin binding
CWI35_RS04660	COG0768	penicillin binding
CWI35_RS04665	COG4839	cell division protein FtsL
CWI35_RS04670	COG0275	rRNA processing
CWI35_RS04675	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CWI35_RS04685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CWI35_RS04695	COG1024	Enoyl-CoA hydratase
CWI35_RS04700	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CWI35_RS04705	COG1399	metal-binding, possibly nucleic acid-binding protein
CWI35_RS04710	COG1323	Belongs to the UPF0348 family
CWI35_RS04715	COG3480	Lon protease (S16) C-terminal proteolytic domain
CWI35_RS04720	COG1752	Esterase of the alpha-beta hydrolase superfamily
CWI35_RS04725	COG3314	Sporulation integral membrane protein YlbJ
CWI35_RS04730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CWI35_RS04735	COG0742	ribosomal rna small subunit methyltransferase
CWI35_RS04750	COG4471	UPF0298 protein
CWI35_RS04755	COG3679	Belongs to the UPF0342 family
CWI35_RS04775	COG2340	Cysteine-rich secretory protein family
CWI35_RS04780	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CWI35_RS04800	COG3336	cytochrome c oxidase
CWI35_RS04825	COG0109	protoheme IX farnesyltransferase activity
CWI35_RS04830	COG1612	heme a metabolic process
CWI35_RS04835	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CWI35_RS04840	COG0772	Belongs to the SEDS family
CWI35_RS04845	COG4838	Belongs to the UPF0358 family
CWI35_RS04850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CWI35_RS04855	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CWI35_RS04865	COG4896	Protein conserved in bacteria
CWI35_RS04880	COG1217	gtp-binding protein TYPA
CWI35_RS04895	COG0483	inositol monophosphate 1-phosphatase activity
CWI35_RS04910	COG1982	Orn Lys Arg decarboxylase major
CWI35_RS04955	COG0561	phosphatase activity
CWI35_RS04960	COG5503	Protein of unknown function (DUF1447)
CWI35_RS04965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CWI35_RS04970	COG0569	domain protein
CWI35_RS04980	COG1473	amidohydrolase
CWI35_RS04985	COG2171	N-acyltransferase activity
CWI35_RS04990	COG0517	IMP dehydrogenase activity
CWI35_RS05005	COG2200	EAL domain
CWI35_RS05010	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_RS05015	COG1408	metallophosphoesterase
CWI35_RS05045	COG0598	Magnesium transport protein CorA
CWI35_RS05055	COG0436	Aminotransferase
CWI35_RS05085	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_RS05100	COG2084	Dehydrogenase
CWI35_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_RS05115	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWI35_RS05120	COG0567	Dehydrogenase, E1 component
CWI35_RS05130	COG0840	transmembrane signaling receptor activity
CWI35_RS05140	COG0456	acetyltransferase
CWI35_RS05160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWI35_RS05160	COG1263	PTS System
CWI35_RS05160	COG2190	(PTS) system
CWI35_RS05165	COG3711	transcriptional antiterminator
CWI35_RS05170	COG0596	Alpha beta hydrolase
CWI35_RS05175	COG0475	glutathione-regulated potassium exporter activity
CWI35_RS05180	COG4191	Histidine kinase
CWI35_RS05190	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_RS05205	COG3773	Cell wall hydrolase
CWI35_RS05210	COG4873	Protein conserved in bacteria
CWI35_RS05215	COG0702	epimerase
CWI35_RS05220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CWI35_RS05230	COG0720	synthase
CWI35_RS05235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CWI35_RS05255	COG0840	transmembrane signaling receptor activity
CWI35_RS05260	COG3949	Membrane
CWI35_RS05270	COG0542	response to heat
CWI35_RS05305	COG1131	(ABC) transporter
CWI35_RS05335	COG0531	amino acid
CWI35_RS05340	COG1506	peptidase
CWI35_RS05340	COG0823	Involved in the tonB-independent uptake of proteins
CWI35_RS05340	COG4946	Tricorn protease homolog
CWI35_RS05350	COG4869	propanediol catabolic process
CWI35_RS05355	COG1846	Transcriptional regulator
CWI35_RS05365	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CWI35_RS05370	COG0235	Class ii aldolase
CWI35_RS05375	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CWI35_RS05380	COG1850	ribulose-bisphosphate carboxylase activity
CWI35_RS05385	COG0436	Aminotransferase
CWI35_RS05390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWI35_RS05395	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CWI35_RS05400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CWI35_RS05405	COG1879	ABC-type sugar transport system periplasmic component
CWI35_RS05410	COG1129	ABC transporter
CWI35_RS05415	COG4214	carbohydrate transport
CWI35_RS05420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWI35_RS05425	COG5002	protein histidine kinase activity
CWI35_RS05440	COG2814	Major facilitator Superfamily
CWI35_RS05475	COG0531	amino acid
CWI35_RS05480	COG3162	membrane
CWI35_RS05485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWI35_RS05560	COG4948	Mandelate Racemase Muconate Lactonizing
CWI35_RS05570	COG1473	amidohydrolase
CWI35_RS05580	COG2966	Psort location CytoplasmicMembrane, score
CWI35_RS05605	COG0675	Transposase, IS605 OrfB family
CWI35_RS05625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CWI35_RS05650	COG1418	mRNA catabolic process
CWI35_RS05660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWI35_RS05665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWI35_RS05670	COG0367	asparagine synthase
CWI35_RS05675	COG4990	cell redox homeostasis
CWI35_RS05700	COG2217	Heavy metal translocating P-type atpase
CWI35_RS05705	COG1937	Protein conserved in bacteria
CWI35_RS05715	COG2723	6-phospho-beta-galactosidase activity
CWI35_RS05735	COG2801	Transposase and inactivated derivatives
CWI35_RS05755	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CWI35_RS05760	COG0697	spore germination
CWI35_RS05765	COG0693	protein deglycase activity
CWI35_RS05815	COG3328	transposase activity
CWI35_RS05845	COG0582	viral genome integration into host DNA
CWI35_RS05865	COG3437	response regulator, receiver
CWI35_RS05865	COG2770	Histidine kinase
CWI35_RS05870	COG0626	cystathionine gamma-synthase activity
CWI35_RS05875	COG0626	cystathionine gamma-synthase activity
CWI35_RS05880	COG2382	esterase
CWI35_RS05885	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CWI35_RS05910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWI35_RS05915	COG2323	membrane
CWI35_RS05930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWI35_RS06005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CWI35_RS06010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWI35_RS06015	COG0438	transferase activity, transferring glycosyl groups
CWI35_RS06020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CWI35_RS06025	COG0438	transferase activity, transferring glycosyl groups
CWI35_RS06040	COG0772	Belongs to the SEDS family
CWI35_RS06045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CWI35_RS06050	COG0564	pseudouridine synthase activity
CWI35_RS06060	COG2357	RelA SpoT domain protein
CWI35_RS06070	COG4116	CYTH
CWI35_RS06075	COG0741	lytic transglycosylase activity
CWI35_RS06080	COG2346	COG2346, Truncated hemoglobins
CWI35_RS06085	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CWI35_RS06095	COG1164	Oligoendopeptidase f
CWI35_RS06105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWI35_RS06110	COG4862	establishment of competence for transformation
CWI35_RS06115	COG0861	Integral membrane protein TerC family
CWI35_RS06120	COG1393	Belongs to the ArsC family
CWI35_RS06130	COG4608	Belongs to the ABC transporter superfamily
CWI35_RS06135	COG0444	Belongs to the ABC transporter superfamily
CWI35_RS06140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWI35_RS06145	COG0601	transmembrane transport
CWI35_RS06150	COG4166	transmembrane transport
CWI35_RS06175	COG5504	Zn-dependent protease
CWI35_RS06180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWI35_RS06185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWI35_RS06195	COG2267	carboxylic ester hydrolase activity
CWI35_RS06240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CWI35_RS06245	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CWI35_RS06250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CWI35_RS06255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWI35_RS06275	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CWI35_RS06280	COG0314	molybdopterin synthase activity
CWI35_RS06285	COG1763	Mo-molybdopterin cofactor biosynthetic process
CWI35_RS06290	COG0303	'Molybdopterin
CWI35_RS06295	COG3290	protein histidine kinase activity
CWI35_RS06295	COG0840	transmembrane signaling receptor activity
CWI35_RS06305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CWI35_RS06310	COG4149	molybdate abc transporter
CWI35_RS06315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWI35_RS06325	COG2223	nitrite transmembrane transporter activity
CWI35_RS06355	COG0535	radical SAM domain protein
CWI35_RS06365	COG0746	molybdenum cofactor guanylyltransferase activity
CWI35_RS06395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWI35_RS06415	COG2151	metal-sulfur cluster biosynthetic enzyme
CWI35_RS06420	COG1073	alpha beta
CWI35_RS06425	COG0561	phosphatase activity
CWI35_RS06435	COG1307	EDD domain protein, DegV family
CWI35_RS06450	COG1666	GTP binding
CWI35_RS06470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWI35_RS06475	COG4555	ABC transporter
CWI35_RS06505	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_RS06510	COG2204	response regulator
CWI35_RS06515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWI35_RS06515	COG4191	Histidine kinase
CWI35_RS06530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CWI35_RS06535	COG1177	transmembrane transport
CWI35_RS06540	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWI35_RS06545	COG3842	ATPase activity
CWI35_RS06550	COG4133	protoheme IX ABC transporter activity
CWI35_RS06575	COG0646	methionine synthase
CWI35_RS06575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CWI35_RS06580	COG1410	methionine synthase
CWI35_RS06580	COG0646	methionine synthase
CWI35_RS06600	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_RS06615	COG4122	O-methyltransferase activity
CWI35_RS06625	COG0366	Alpha amylase catalytic
CWI35_RS06630	COG3833	ABC-type maltose transport systems, permease component
CWI35_RS06635	COG1175	transmembrane transport
CWI35_RS06640	COG2182	Extracellular solute-binding protein
CWI35_RS06655	COG1917	Cupin 2, conserved barrel domain protein
CWI35_RS06655	COG2207	Transcriptional regulator
CWI35_RS06660	COG0534	Mate efflux family protein
CWI35_RS06670	COG0367	asparagine synthase
CWI35_RS06690	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWI35_RS06700	COG2311	Membrane
CWI35_RS06705	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_RS06755	COG0419	ATPase involved in DNA repair
CWI35_RS06760	COG0420	3'-5' exonuclease activity
CWI35_RS06765	COG1074	ATP-dependent DNA helicase activity
CWI35_RS06770	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CWI35_RS06780	COG0398	Pfam SNARE associated Golgi protein
CWI35_RS06785	COG4903	ComK protein
CWI35_RS06795	COG2224	Isocitrate lyase
CWI35_RS06810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CWI35_RS06820	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CWI35_RS06835	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_RS06840	COG1234	tRNA 3'-trailer cleavage
CWI35_RS06850	COG1511	domain protein
CWI35_RS06855	COG1309	transcriptional regulator
CWI35_RS06860	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CWI35_RS06865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CWI35_RS06870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CWI35_RS06875	COG3069	C4-dicarboxylate transmembrane transporter activity
CWI35_RS06880	COG4473	ABC transporter
CWI35_RS06885	COG1131	(ABC) transporter
CWI35_RS06900	COG0537	adenosine 5'-monophosphoramidase activity
CWI35_RS06905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWI35_RS06925	COG1846	Transcriptional regulator
CWI35_RS06940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CWI35_RS06955	COG3481	metal-dependent phosphohydrolase, HD sub domain
CWI35_RS06960	COG1668	transmembrane transport
CWI35_RS06965	COG4152	abc transporter atp-binding protein
CWI35_RS06975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWI35_RS06980	COG0561	phosphatase activity
CWI35_RS06985	COG3679	Belongs to the UPF0342 family
CWI35_RS06990	COG4399	Belongs to the UPF0754 family
CWI35_RS07000	COG0189	ligase activity
CWI35_RS07005	COG0189	ligase activity
CWI35_RS07025	COG2508	Transcriptional regulator
CWI35_RS07030	COG3842	ATPase activity
CWI35_RS07045	COG1253	flavin adenine dinucleotide binding
CWI35_RS07070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CWI35_RS07075	COG2022	thiamine diphosphate biosynthetic process
CWI35_RS07085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWI35_RS07090	COG0352	thiamine-phosphate diphosphorylase activity
CWI35_RS07095	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CWI35_RS07100	COG1122	ATPase activity
CWI35_RS07105	COG4721	ABC-type cobalt transport system, permease component
CWI35_RS07110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CWI35_RS07120	COG2814	Major facilitator Superfamily
CWI35_RS07130	COG2318	DinB family
CWI35_RS07135	COG0366	Alpha amylase catalytic
CWI35_RS07140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CWI35_RS07145	COG2879	small protein
CWI35_RS07150	COG1966	Carbon starvation protein
CWI35_RS07165	COG0861	Integral membrane protein TerC family
CWI35_RS07175	COG2076	Multidrug Resistance protein
CWI35_RS07185	COG1294	oxidase, subunit
CWI35_RS07190	COG1271	oxidase subunit
CWI35_RS07220	COG0210	DNA helicase
CWI35_RS07260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CWI35_RS07270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CWI35_RS07270	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CWI35_RS07280	COG1247	-acetyltransferase
CWI35_RS07285	COG2226	methyltransferase
CWI35_RS07295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CWI35_RS07300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWI35_RS07305	COG0798	PFAM Bile acid sodium symporter
CWI35_RS07310	COG0640	Transcriptional regulator
CWI35_RS07335	COG2072	flavoprotein involved in K transport
CWI35_RS07345	COG0640	Transcriptional regulator
CWI35_RS07355	COG1937	Protein conserved in bacteria
CWI35_RS07360	COG0534	Mate efflux family protein
CWI35_RS07420	COG2719	SpoVR family
CWI35_RS07425	COG0586	Pfam SNARE associated Golgi protein
CWI35_RS07440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWI35_RS07445	COG0517	IMP dehydrogenase activity
CWI35_RS07450	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CWI35_RS07470	COG0564	pseudouridine synthase activity
CWI35_RS07475	COG1253	flavin adenine dinucleotide binding
CWI35_RS07480	COG2738	Putative neutral zinc metallopeptidase
CWI35_RS07485	COG0656	L-ascorbic acid biosynthetic process
CWI35_RS07490	COG1301	dicarboxylic acid transport
CWI35_RS07495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CWI35_RS07500	COG3290	protein histidine kinase activity
CWI35_RS07525	COG2766	serine protein kinase
CWI35_RS07545	COG3382	B3 4 domain protein
CWI35_RS07680	COG0735	belongs to the Fur family
CWI35_RS07685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CWI35_RS07695	COG0039	L-malate dehydrogenase activity
CWI35_RS07710	COG4555	ABC transporter
CWI35_RS07715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWI35_RS07720	COG4129	membrane
CWI35_RS07725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWI35_RS07730	COG0601	transmembrane transport
CWI35_RS07735	COG0747	negative chemotaxis
CWI35_RS07740	COG4608	Belongs to the ABC transporter superfamily
CWI35_RS07745	COG0444	Belongs to the ABC transporter superfamily
CWI35_RS07750	COG3557	Belongs to the UPF0374 family
CWI35_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_RS07780	COG2223	nitrite transmembrane transporter activity
CWI35_RS07785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CWI35_RS07790	COG5609	conserved protein (DUF2294)
CWI35_RS07795	COG3383	formate dehydrogenase (NAD+) activity
CWI35_RS07800	COG2427	Protein of unknown function (DUF1641)
CWI35_RS07805	COG1988	membrane-bound metal-dependent
CWI35_RS07825	COG2137	regulation of response to DNA damage stimulus
CWI35_RS07830	COG1090	epimerase
CWI35_RS07850	COG1442	glycosyl transferase family 8
CWI35_RS07855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWI35_RS07860	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS07870	COG3002	Belongs to the UPF0753 family
CWI35_RS07875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWI35_RS07880	COG5609	conserved protein (DUF2294)
CWI35_RS07895	COG0789	Transcriptional regulator
CWI35_RS07905	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CWI35_RS07915	COG2197	response regulator
CWI35_RS07920	COG4585	Histidine kinase
CWI35_RS07925	COG4758	membrane
CWI35_RS07945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWI35_RS07950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CWI35_RS07965	COG0535	radical SAM domain protein
CWI35_RS07975	COG0387	Pfam Sodium calcium exchanger
CWI35_RS07980	COG0477	Major facilitator Superfamily
CWI35_RS07990	COG1295	ribonuclease BN
CWI35_RS07995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWI35_RS08000	COG4840	Belongs to the UPF0435 family
CWI35_RS08005	COG0175	sulfate reduction
CWI35_RS08015	COG2046	Belongs to the sulfate adenylyltransferase family
CWI35_RS08020	COG0529	Catalyzes the synthesis of activated sulfate
CWI35_RS08035	COG1254	Belongs to the acylphosphatase family
CWI35_RS08045	COG0010	Belongs to the arginase family
CWI35_RS08050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CWI35_RS08070	COG1648	precorrin-2 dehydrogenase activity
CWI35_RS08070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CWI35_RS08085	COG3300	MHYT domain
CWI35_RS08085	COG5001	Diguanylate cyclase
CWI35_RS08090	COG0791	NLP P60 protein
CWI35_RS08090	COG1388	LysM domain
CWI35_RS08095	COG1077	Cell shape determining protein MreB Mrl
CWI35_RS08100	COG1620	l-lactate permease
CWI35_RS08105	COG2186	Transcriptional regulator
CWI35_RS08110	COG0247	lactate metabolic process
CWI35_RS08115	COG1139	Iron-sulfur cluster binding protein
CWI35_RS08120	COG1556	Lactate utilization protein
CWI35_RS08165	COG0861	Integral membrane protein TerC family
CWI35_RS08170	COG2986	histidine ammonia-lyase
CWI35_RS08195	COG0243	molybdopterin cofactor binding
CWI35_RS08205	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CWI35_RS08210	COG2068	MobA-Related Protein
CWI35_RS08215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CWI35_RS08230	COG2814	Major facilitator Superfamily
CWI35_RS08240	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_RS08245	COG0028	Belongs to the TPP enzyme family
CWI35_RS08250	COG0436	Aminotransferase
CWI35_RS08260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CWI35_RS08270	COG1714	RDD family
CWI35_RS08275	COG2208	phosphoserine phosphatase activity
CWI35_RS08280	COG1366	Belongs to the anti-sigma-factor antagonist family
CWI35_RS08290	COG2197	response regulator
CWI35_RS08305	COG0297	glycogen (starch) synthase activity
CWI35_RS08310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CWI35_RS08315	COG0673	inositol 2-dehydrogenase activity
CWI35_RS08320	COG4326	sporulation control protein
CWI35_RS08325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWI35_RS08330	COG1959	2 iron, 2 sulfur cluster binding
CWI35_RS08370	COG2801	Transposase and inactivated derivatives
CWI35_RS08405	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CWI35_RS08420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWI35_RS08425	COG1597	lipid kinase activity
CWI35_RS08430	COG2268	Band 7 protein
CWI35_RS08465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWI35_RS08475	COG5002	protein histidine kinase activity
CWI35_RS08480	COG1511	domain protein
CWI35_RS08575	COG0789	Transcriptional regulator
CWI35_RS08585	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CWI35_RS08590	COG1518	maintenance of DNA repeat elements
CWI35_RS08665	COG1732	Glycine betaine
CWI35_RS08670	COG1125	glycine betaine transport
CWI35_RS08670	COG0517	IMP dehydrogenase activity
CWI35_RS08675	COG1174	glycine betaine transport
CWI35_RS08680	COG1131	(ABC) transporter
CWI35_RS08700	COG5002	protein histidine kinase activity
CWI35_RS08770	COG1131	(ABC) transporter
CWI35_RS08815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWI35_RS08820	COG0154	amidase activity
CWI35_RS08845	COG1231	oxidoreductase activity
CWI35_RS08850	COG1611	Belongs to the LOG family
CWI35_RS08855	COG4851	CamS sex pheromone cAM373 precursor
CWI35_RS08860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWI35_RS08870	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CWI35_RS08875	COG4496	protein, YerC YecD
CWI35_RS08880	COG1470	cell adhesion involved in biofilm formation
CWI35_RS08885	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CWI35_RS08895	COG0151	Belongs to the GarS family
CWI35_RS08900	COG0138	bifunctional purine biosynthesis protein purh
CWI35_RS08905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CWI35_RS08910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CWI35_RS08915	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CWI35_RS08920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWI35_RS08925	COG0047	phosphoribosylformylglycinamidine synthase activity
CWI35_RS08930	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWI35_RS08935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CWI35_RS08940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CWI35_RS08945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CWI35_RS08950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CWI35_RS08975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWI35_RS08980	COG2252	PERMEase
CWI35_RS08985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CWI35_RS08985	COG0519	Catalyzes the synthesis of GMP from XMP
CWI35_RS08995	COG1305	Transglutaminase-like
CWI35_RS09000	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CWI35_RS09005	COG0714	Associated with various cellular activities
CWI35_RS09010	COG1914	H( )-stimulated, divalent metal cation uptake system
CWI35_RS09015	COG0114	fumarate hydratase activity
CWI35_RS09050	COG0459	protein refolding
CWI35_RS09055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CWI35_RS09060	COG1266	CAAX protease self-immunity
CWI35_RS09075	COG0805	protein transport
CWI35_RS09080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWI35_RS09085	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CWI35_RS09090	COG0315	cyclic pyranopterin monophosphate synthase activity
CWI35_RS09095	COG0488	(ABC) transporter
CWI35_RS09105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWI35_RS09110	COG0456	acetyltransferase
CWI35_RS09115	COG1214	PFAM Peptidase M22, glycoprotease
CWI35_RS09120	COG0802	atpase or kinase
CWI35_RS09195	COG3091	SprT-like family
CWI35_RS09205	COG2183	response to ionizing radiation
CWI35_RS09210	COG2337	Toxic component of a toxin-antitoxin (TA) module
CWI35_RS09215	COG0864	Transcriptional regulator
CWI35_RS09220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CWI35_RS09225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CWI35_RS09230	COG0736	holo-[acyl-carrier-protein] synthase activity
CWI35_RS09235	COG0705	Rhomboid family
CWI35_RS09240	COG0513	Belongs to the DEAD box helicase family
CWI35_RS09250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CWI35_RS09255	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWI35_RS09260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWI35_RS09265	COG0586	Pfam SNARE associated Golgi protein
CWI35_RS09275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CWI35_RS09280	COG1968	undecaprenyl-diphosphatase activity
CWI35_RS09285	COG1940	carbohydrate kinase activity
CWI35_RS09290	COG5577	PFAM Coat F domain
CWI35_RS09305	COG1971	Probably functions as a manganese efflux pump
CWI35_RS09320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CWI35_RS09325	COG1368	sulfuric ester hydrolase activity
CWI35_RS09330	COG1404	Belongs to the peptidase S8 family
CWI35_RS09350	COG1131	(ABC) transporter
CWI35_RS09360	COG2197	response regulator
CWI35_RS09370	COG2318	DinB family
CWI35_RS09375	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CWI35_RS09405	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS09410	COG3290	protein histidine kinase activity
CWI35_RS09410	COG3829	transcription factor binding
CWI35_RS09415	COG1120	ATPase activity
CWI35_RS09440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWI35_RS09445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWI35_RS09450	COG0586	Pfam SNARE associated Golgi protein
CWI35_RS09455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CWI35_RS09460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CWI35_RS09465	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_RS09475	COG3829	transcription factor binding
CWI35_RS09500	COG2318	DinB family
CWI35_RS09505	COG3739	integral membrane protein
CWI35_RS09510	COG3655	Transcriptional regulator
CWI35_RS09530	COG4174	ABC transporter (Permease)
CWI35_RS09540	COG0426	domain, Protein
CWI35_RS09540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CWI35_RS09555	COG0180	Tryptophanyl-tRNA synthetase
CWI35_RS09595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CWI35_RS09600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWI35_RS09605	COG4856	YbbR-like protein
CWI35_RS09610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CWI35_RS09615	COG5662	AntiSigma factor
CWI35_RS09620	COG1595	DNA-templated transcription, initiation
CWI35_RS09680	COG0726	polysaccharide deacetylase
CWI35_RS09685	COG2194	sulfuric ester hydrolase activity
CWI35_RS09695	COG0489	protein tyrosine kinase activity
CWI35_RS09700	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWI35_RS09710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CWI35_RS09715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CWI35_RS09720	COG0101	tRNA pseudouridine synthase activity
CWI35_RS09725	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CWI35_RS09730	COG1122	ATPase activity
CWI35_RS09735	COG1122	ATPase activity
CWI35_RS09740	COG0203	ribosomal protein L17
CWI35_RS09745	COG0202	RNA polymerase activity
CWI35_RS09750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CWI35_RS09755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWI35_RS09760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWI35_RS09765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWI35_RS09770	COG0024	Methionine aminopeptidase
CWI35_RS09775	COG0563	adenylate kinase activity
CWI35_RS09780	COG0201	protein transport
CWI35_RS09795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CWI35_RS09800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CWI35_RS09810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CWI35_RS09815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWI35_RS09820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWI35_RS09835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CWI35_RS09845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CWI35_RS09850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CWI35_RS09855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CWI35_RS09860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CWI35_RS09865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CWI35_RS09870	COG0089	rRNA binding
CWI35_RS09875	COG0088	Forms part of the polypeptide exit tunnel
CWI35_RS09880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CWI35_RS09885	COG0051	transcription antitermination factor activity, RNA binding
CWI35_RS09895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWI35_RS09900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWI35_RS09905	COG0049	tRNA binding
CWI35_RS09910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CWI35_RS09915	COG1358	cellular component organization or biogenesis
CWI35_RS09920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CWI35_RS09925	COG0085	RNA polymerase activity
CWI35_RS09945	COG2813	Specifically methylates the guanine in position
CWI35_RS09950	COG0222	ribosome binding
CWI35_RS09955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CWI35_RS09960	COG0081	regulation of translation
CWI35_RS09965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CWI35_RS09970	COG0250	Participates in transcription elongation, termination and antitermination
CWI35_RS09975	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWI35_RS09980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWI35_RS09990	COG3688	RNA-binding protein containing a PIN domain
CWI35_RS09995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWI35_RS10005	COG0215	cysteine-tRNA ligase activity
CWI35_RS10010	COG1045	serine acetyltransferase
CWI35_RS10015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CWI35_RS10020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CWI35_RS10025	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CWI35_RS10030	COG4956	integral membrane protein (PIN domain superfamily)
CWI35_RS10035	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CWI35_RS10040	COG0542	response to heat
CWI35_RS10045	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CWI35_RS10050	COG3880	PFAM UvrB UvrC protein
CWI35_RS10125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CWI35_RS10130	COG1396	sequence-specific DNA binding
CWI35_RS10135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CWI35_RS10140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CWI35_RS10145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CWI35_RS10150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWI35_RS10155	COG0512	Glutamine amidotransferase of anthranilate synthase
CWI35_RS10160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CWI35_RS10165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CWI35_RS10170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CWI35_RS10175	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CWI35_RS10180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWI35_RS10185	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CWI35_RS10190	COG0037	tRNA processing
CWI35_RS10195	COG0515	serine threonine protein kinase
CWI35_RS10200	COG2304	oxidoreductase activity
CWI35_RS10205	COG2208	phosphoserine phosphatase activity
CWI35_RS10225	COG1098	S1 RNA binding domain
CWI35_RS10250	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CWI35_RS10255	COG3956	TIGRFAM MazG family protein
CWI35_RS10260	COG2244	polysaccharide biosynthetic process
CWI35_RS10265	COG2002	toxin-antitoxin pair type II binding
CWI35_RS10270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CWI35_RS10280	COG0193	aminoacyl-tRNA hydrolase activity
CWI35_RS10285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CWI35_RS10295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWI35_RS10300	COG2088	sporulation resulting in formation of a cellular spore
CWI35_RS10305	COG0251	oxidation-reduction process
CWI35_RS10310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWI35_RS10315	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CWI35_RS10330	COG4466	Protein conserved in bacteria
CWI35_RS10340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CWI35_RS10350	COG3584	3D domain protein
CWI35_RS10350	COG3583	domain protein
CWI35_RS10355	COG0084	hydrolase, TatD family'
CWI35_RS10365	COG2002	toxin-antitoxin pair type II binding
CWI35_RS10370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CWI35_RS10375	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CWI35_RS10380	COG4467	Involved in initiation control of chromosome replication
CWI35_RS10385	COG1774	PSP1 C-terminal conserved region
CWI35_RS10390	COG0470	DNA polymerase III
CWI35_RS10395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CWI35_RS10400	COG1982	Orn Lys Arg decarboxylase major
CWI35_RS10450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CWI35_RS10455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CWI35_RS10460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CWI35_RS10470	COG0590	tRNA wobble adenosine to inosine editing
CWI35_RS10475	COG3858	chitin binding
CWI35_RS10475	COG1388	LysM domain
CWI35_RS10480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CWI35_RS10485	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CWI35_RS10490	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CWI35_RS10500	COG0517	IMP dehydrogenase activity
CWI35_RS10500	COG0516	GMP reductase activity
CWI35_RS10535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CWI35_RS10540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWI35_RS10545	COG0187	DNA topoisomerase II activity
CWI35_RS10550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWI35_RS10560	COG0592	DNA-directed DNA polymerase activity
CWI35_RS10565	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWI35_RS10570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CWI35_RS10575	COG0594	ribonuclease P activity
CWI35_RS10580	COG0706	membrane insertase activity
CWI35_RS10585	COG1847	R3H domain protein
CWI35_RS10595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CWI35_RS10600	COG0445	tRNA wobble uridine modification
CWI35_RS10605	COG0357	Ribosomal RNA small subunit methyltransferase G
CWI35_RS10610	COG1475	DNA binding
CWI35_RS10615	COG1192	Involved in chromosome partitioning
CWI35_RS10620	COG1475	DNA binding
CWI35_RS10635	COG0668	transmembrane transport
CWI35_RS10640	COG4481	Protein conserved in bacteria
CWI35_RS10645	COG0243	molybdopterin cofactor binding
CWI35_RS10650	COG0012	GTP binding
CWI35_RS10655	COG0360	Binds together with S18 to 16S ribosomal RNA
CWI35_RS10660	COG0629	single-stranded DNA binding
CWI35_RS10665	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CWI35_RS10670	COG4241	membrane
CWI35_RS10675	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CWI35_RS10680	COG0359	binds to the 23S rRNA
CWI35_RS10685	COG0305	Participates in initiation and elongation during chromosome replication
CWI35_RS10690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CWI35_RS10695	COG0745	RESPONSE REGULATOR receiver
CWI35_RS10700	COG5002	protein histidine kinase activity
CWI35_RS10705	COG4863	YycH protein
CWI35_RS10710	COG4853	Protein conserved in bacteria
CWI35_RS10715	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CWI35_RS10720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWI35_RS10730	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CWI35_RS10740	COG1929	Belongs to the glycerate kinase type-1 family
CWI35_RS10750	COG1482	cell wall glycoprotein biosynthetic process
CWI35_RS10755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWI35_RS10755	COG0723	plastoquinol--plastocyanin reductase activity
CWI35_RS10770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWI35_RS10780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CWI35_RS10785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CWI35_RS10795	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CWI35_RS10805	COG0765	amino acid transport
CWI35_RS10815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWI35_RS10820	COG3153	acetyltransferase
CWI35_RS10820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWI35_RS10825	COG0351	phosphomethylpyrimidine kinase
CWI35_RS10830	COG4636	protein conserved in cyanobacteria
CWI35_RS10835	COG0686	Belongs to the AlaDH PNT family
CWI35_RS10840	COG2508	Transcriptional regulator
CWI35_RS10840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CWI35_RS10845	COG0473	3-isopropylmalate dehydrogenase activity
CWI35_RS10850	COG2190	(PTS) system
CWI35_RS10855	COG3711	transcriptional antiterminator
CWI35_RS10860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWI35_RS10860	COG1263	PTS System
CWI35_RS10865	COG1621	beta-fructofuranosidase activity
CWI35_RS10875	COG0581	inorganic phosphate transmembrane transporter activity
CWI35_RS10880	COG0573	inorganic phosphate transmembrane transporter activity
CWI35_RS10885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CWI35_RS10900	COG0477	Major facilitator Superfamily
CWI35_RS10905	COG1216	Glycosyl transferase, family 2
CWI35_RS10910	COG0423	glycine-tRNA ligase activity
CWI35_RS10920	COG2208	phosphoserine phosphatase activity
CWI35_RS10925	COG1191	sigma factor activity
CWI35_RS10930	COG2172	sigma factor antagonist activity
CWI35_RS10940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CWI35_RS10950	COG2363	Small membrane protein
CWI35_RS10960	COG3773	Cell wall hydrolase
CWI35_RS10965	COG3253	May function as heme-dependent peroxidase
CWI35_RS10970	COG0280	phosphate acetyltransferase
CWI35_RS10980	COG0095	Lipoate-protein ligase
CWI35_RS10990	COG4844	belongs to the
CWI35_RS10995	COG1078	dGTPase activity
CWI35_RS11000	COG3465	dGTPase activity
CWI35_RS11005	COG2252	PERMEase
CWI35_RS11010	COG1942	4-Oxalocrotonate Tautomerase
CWI35_RS11015	COG1994	Peptidase M50
CWI35_RS11025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWI35_RS11030	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CWI35_RS11035	COG0010	Belongs to the arginase family
CWI35_RS11050	COG0018	arginyl-trna synthetase
CWI35_RS11060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWI35_RS11065	COG0247	lactate metabolic process
CWI35_RS11065	COG2181	nitrate reductase activity
CWI35_RS11070	COG0183	Belongs to the thiolase family
CWI35_RS11080	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWI35_RS11085	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS11090	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS11100	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CWI35_RS11100	COG1703	isobutyryl-CoA mutase activity
CWI35_RS11100	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CWI35_RS11105	COG3343	RNA polymerase activity
CWI35_RS11110	COG0504	CTP synthase activity
CWI35_RS11115	COG4821	SIS domain
CWI35_RS11120	COG2204	response regulator
CWI35_RS11130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWI35_RS11135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWI35_RS11140	COG1494	fructose-1,6-bisphosphatase
CWI35_RS11145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CWI35_RS11150	COG0254	rRNA binding
CWI35_RS11155	COG1435	thymidine kinase activity
CWI35_RS11170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CWI35_RS11185	COG0009	L-threonylcarbamoyladenylate synthase
CWI35_RS11195	COG1971	Probably functions as a manganese efflux pump
CWI35_RS11205	COG0840	transmembrane signaling receptor activity
CWI35_RS11210	COG0698	ribose 5-phosphate isomerase
CWI35_RS11215	COG4475	Protein of unknown function (DUF436)
CWI35_RS11220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CWI35_RS11225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CWI35_RS11245	COG0356	it plays a direct role in the translocation of protons across the membrane
CWI35_RS11255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CWI35_RS11260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWI35_RS11265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CWI35_RS11270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CWI35_RS11275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CWI35_RS11280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CWI35_RS11285	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWI35_RS11290	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWI35_RS11295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWI35_RS11300	COG0649	NAD binding
CWI35_RS11305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CWI35_RS11310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWI35_RS11315	COG0839	Belongs to the complex I subunit 6 family
CWI35_RS11320	COG0713	ATP synthesis coupled electron transport
CWI35_RS11325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWI35_RS11335	COG1007	ATP synthesis coupled electron transport
CWI35_RS11345	COG4836	Membrane
CWI35_RS11355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWI35_RS11360	COG2385	sporulation resulting in formation of a cellular spore
CWI35_RS11365	COG0739	heme binding
CWI35_RS11370	COG1522	sequence-specific DNA binding
CWI35_RS11375	COG0601	transmembrane transport
CWI35_RS11380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWI35_RS11385	COG0747	negative chemotaxis
CWI35_RS11390	COG0444	Belongs to the ABC transporter superfamily
CWI35_RS11395	COG4608	Belongs to the ABC transporter superfamily
CWI35_RS11405	COG2059	Chromate
CWI35_RS11410	COG2059	Chromate
CWI35_RS11425	COG1609	Transcriptional regulator
CWI35_RS11430	COG1077	Cell shape determining protein MreB Mrl
CWI35_RS11435	COG4786	Flagellar basal body rod
CWI35_RS11440	COG4786	Flagellar basal body rod
CWI35_RS11450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CWI35_RS11460	COG1316	TRANSCRIPTIONal
CWI35_RS11545	COG1376	ErfK ybiS ycfS ynhG family protein
CWI35_RS11560	COG0697	spore germination
CWI35_RS11580	COG0395	ABC-type sugar transport system, permease component
CWI35_RS11585	COG1175	transmembrane transport
CWI35_RS11605	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CWI35_RS11610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CWI35_RS11625	COG3189	MarR family transcriptional regulator
CWI35_RS11630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWI35_RS11630	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CWI35_RS11640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWI35_RS11650	COG1405	negative regulation of cell septum assembly
CWI35_RS11650	COG3012	SEC-C Motif Domain Protein
CWI35_RS11665	COG1405	negative regulation of cell septum assembly
CWI35_RS11665	COG3012	SEC-C Motif Domain Protein
CWI35_RS11675	COG0653	protein targeting
CWI35_RS11690	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWI35_RS11695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CWI35_RS11720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWI35_RS11740	COG1609	Transcriptional regulator
CWI35_RS11745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWI35_RS11760	COG0640	Transcriptional regulator
CWI35_RS11770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWI35_RS11780	COG0673	inositol 2-dehydrogenase activity
CWI35_RS11785	COG0346	lactoylglutathione lyase activity
CWI35_RS11810	COG0277	FAD linked oxidase domain protein
CWI35_RS11820	COG1486	melibiose metabolic process
CWI35_RS11835	COG2972	Histidine kinase
CWI35_RS11840	COG2207	Transcriptional regulator
CWI35_RS11840	COG4753	response regulator
CWI35_RS11850	COG1175	transmembrane transport
CWI35_RS11875	COG2011	ABC-type metal ion transport system permease component
CWI35_RS11880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CWI35_RS11885	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS11890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWI35_RS11895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWI35_RS11900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWI35_RS11910	COG0583	DNA-binding transcription factor activity
CWI35_RS11915	COG0431	NADPH-dependent FMN reductase
CWI35_RS11920	COG1940	carbohydrate kinase activity
CWI35_RS11925	COG1309	transcriptional regulator
CWI35_RS11930	COG0477	Major facilitator Superfamily
CWI35_RS11940	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_RS11960	COG0527	aspartate kinase activity
CWI35_RS11970	COG3764	Sortase (surface protein transpeptidase)
CWI35_RS11980	COG0629	single-stranded DNA binding
CWI35_RS11995	COG0791	NLP P60 protein
CWI35_RS11995	COG1388	LysM domain
CWI35_RS12005	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWI35_RS12040	COG3344	reverse transcriptase
CWI35_RS12050	COG0737	Belongs to the 5'-nucleotidase family
CWI35_RS12090	COG3409	Peptidoglycan-binding domain 1 protein
CWI35_RS12090	COG0793	Belongs to the peptidase S41A family
CWI35_RS12100	COG0653	protein targeting
CWI35_RS12105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWI35_RS12120	COG0673	inositol 2-dehydrogenase activity
CWI35_RS12155	COG0438	transferase activity, transferring glycosyl groups
CWI35_RS12170	COG2385	sporulation resulting in formation of a cellular spore
CWI35_RS12170	COG2247	cell wall binding repeat
CWI35_RS12180	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWI35_RS12185	COG1316	TRANSCRIPTIONal
CWI35_RS12190	COG1739	Uncharacterized protein family UPF0029
CWI35_RS12195	COG4585	Histidine kinase
CWI35_RS12200	COG2197	response regulator
CWI35_RS12205	COG1307	EDD domain protein, DegV family
CWI35_RS12215	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CWI35_RS12220	COG1040	competence protein
CWI35_RS12240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWI35_RS12245	COG1728	Protein conserved in bacteria
CWI35_RS12265	COG1256	bacterial-type flagellum assembly
CWI35_RS12265	COG4786	Flagellar basal body rod
CWI35_RS12270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWI35_RS12280	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CWI35_RS12285	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CWI35_RS12290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWI35_RS12300	COG1086	Polysaccharide biosynthesis protein
CWI35_RS12320	COG0438	transferase activity, transferring glycosyl groups
CWI35_RS12320	COG0297	glycogen (starch) synthase activity
CWI35_RS12335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CWI35_RS12340	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CWI35_RS12350	COG2089	acid synthase
CWI35_RS12355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWI35_RS12360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWI35_RS12380	COG1334	flagellar protein FlaG
CWI35_RS12385	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CWI35_RS12390	COG1516	flagellar protein fliS
CWI35_RS12420	COG0653	protein targeting
CWI35_RS12440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWI35_RS12460	COG2884	Cell division ATP-binding protein ftsE
CWI35_RS12465	COG2177	Part of the ABC transporter FtsEX involved in
CWI35_RS12470	COG0739	heme binding
CWI35_RS12505	COG1741	Belongs to the pirin family
CWI35_RS12520	COG3409	Peptidoglycan-binding domain 1 protein
CWI35_RS12520	COG0793	Belongs to the peptidase S41A family
CWI35_RS12525	COG0463	Glycosyl transferase, family 2
CWI35_RS12535	COG0789	Transcriptional regulator
CWI35_RS12540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWI35_RS12545	COG4897	Protein conserved in bacteria
CWI35_RS12550	COG0556	nucleotide-excision repair
CWI35_RS12555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CWI35_RS12565	COG1950	PFAM Membrane protein of
CWI35_RS12570	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CWI35_RS12575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CWI35_RS12580	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CWI35_RS12585	COG0546	phosphoglycolate phosphatase activity
CWI35_RS12590	COG0110	maltose O-acetyltransferase activity
CWI35_RS12595	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CWI35_RS12600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CWI35_RS12610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CWI35_RS12615	COG0131	Imidazoleglycerol-phosphate dehydratase
CWI35_RS12620	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CWI35_RS12625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CWI35_RS12630	COG0107	imidazoleglycerol-phosphate synthase activity
CWI35_RS12635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CWI35_RS12635	COG0140	phosphoribosyl-ATP diphosphatase activity
CWI35_RS12650	COG0492	ferredoxin-NADP+ reductase activity
CWI35_RS12655	COG1051	belongs to the nudix hydrolase family
CWI35_RS12660	COG1660	Displays ATPase and GTPase activities
CWI35_RS12665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CWI35_RS12670	COG1481	regulation of sporulation
CWI35_RS12675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWI35_RS12680	COG0740	serine-type endopeptidase activity
CWI35_RS12700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CWI35_RS12720	COG0126	phosphoglycerate kinase activity
CWI35_RS12725	COG0149	triose-phosphate isomerase activity
CWI35_RS12730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CWI35_RS12735	COG0148	phosphopyruvate hydratase activity
CWI35_RS12755	COG2272	Belongs to the type-B carboxylesterase lipase family
CWI35_RS12770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWI35_RS12780	COG0557	exoribonuclease II activity
CWI35_RS12785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CWI35_RS12850	COG2197	response regulator
CWI35_RS12865	COG3546	catalase activity
CWI35_RS12870	COG0583	DNA-binding transcription factor activity
CWI35_RS12885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWI35_RS12905	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_RS12950	COG0469	pyruvate kinase activity
CWI35_RS12960	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CWI35_RS12965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CWI35_RS12975	COG5577	PFAM Coat F domain
CWI35_RS12985	COG0506	proline dehydrogenase activity
CWI35_RS12995	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWI35_RS12995	COG1024	Enoyl-CoA hydratase
CWI35_RS13000	COG0183	Belongs to the thiolase family
CWI35_RS13005	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS13010	COG1393	Belongs to the ArsC family
CWI35_RS13015	COG0509	glycine decarboxylation via glycine cleavage system
CWI35_RS13025	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CWI35_RS13030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWI35_RS13040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CWI35_RS13045	COG2011	ABC-type metal ion transport system permease component
CWI35_RS13050	COG1464	Belongs to the NlpA lipoprotein family
CWI35_RS13060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CWI35_RS13065	COG0396	ATPase activity
CWI35_RS13070	COG0719	Fe-S assembly protein
CWI35_RS13075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CWI35_RS13080	COG0822	iron-sulfur transferase activity
CWI35_RS13085	COG0719	Fe-S assembly protein
CWI35_RS13090	COG1280	lysine exporter protein (LysE YggA)
CWI35_RS13095	COG1801	Protein of unknown function DUF72
CWI35_RS13100	COG0730	response to heat
CWI35_RS13105	COG0737	Belongs to the 5'-nucleotidase family
CWI35_RS13110	COG3377	Domain of unknown function (DUF1805)
CWI35_RS13135	COG0411	ABC transporter
CWI35_RS13150	COG0739	heme binding
CWI35_RS13155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CWI35_RS13165	COG4470	Protein conserved in bacteria
CWI35_RS13180	COG2445	Protein of unknown function DUF86
CWI35_RS13185	COG0647	UMP catabolic process
CWI35_RS13190	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CWI35_RS13195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CWI35_RS13205	COG0460	homoserine dehydrogenase
CWI35_RS13210	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CWI35_RS13220	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CWI35_RS13225	COG4837	Protein of unknown function (DUF1462)
CWI35_RS13230	COG1252	NADH dehydrogenase
CWI35_RS13235	COG4844	belongs to the
CWI35_RS13240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CWI35_RS13245	COG0316	Belongs to the HesB IscA family
CWI35_RS13250	COG5416	Lipopolysaccharide assembly protein A domain
CWI35_RS13255	COG0492	ferredoxin-NADP+ reductase activity
CWI35_RS13260	COG1252	NADH dehydrogenase
CWI35_RS13275	COG3584	3D domain protein
CWI35_RS13285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWI35_RS13290	COG1392	Phosphate transport regulator
CWI35_RS13295	COG0306	phosphate transporter
CWI35_RS13350	COG3328	transposase activity
CWI35_RS13385	COG2814	Major facilitator Superfamily
CWI35_RS13480	COG5018	Exonuclease
CWI35_RS13490	COG2032	superoxide dismutase activity
CWI35_RS13495	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWI35_RS13505	COG1522	sequence-specific DNA binding
CWI35_RS13510	COG0436	Aminotransferase
CWI35_RS13515	COG1098	S1 RNA binding domain
CWI35_RS13520	COG2155	Conserved Protein
CWI35_RS13525	COG1979	alcohol dehydrogenase
CWI35_RS13530	COG0166	Belongs to the GPI family
CWI35_RS13540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CWI35_RS13550	COG2814	Major facilitator Superfamily
CWI35_RS13555	COG1247	-acetyltransferase
CWI35_RS13580	COG1285	pathogenesis
CWI35_RS13775	COG0384	phenazine biosynthesis protein PhzF
CWI35_RS13835	COG1280	lysine exporter protein (LysE YggA)
CWI35_RS13850	COG3279	Response regulator of the LytR AlgR family
CWI35_RS13855	COG0427	acetyl-CoA hydrolase
CWI35_RS13870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CWI35_RS13875	COG1575	Belongs to the MenA family. Type 1 subfamily
CWI35_RS13880	COG1169	isochorismate synthase
CWI35_RS13885	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CWI35_RS13890	COG0596	Alpha beta hydrolase
CWI35_RS13895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CWI35_RS13900	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_RS13940	COG0523	cobalamin synthesis protein
CWI35_RS13945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CWI35_RS13950	COG1854	S-ribosylhomocysteine lyase activity
CWI35_RS13960	COG0783	Belongs to the Dps family
CWI35_RS13965	COG4824	toxin secretion phage lysis holin
CWI35_RS13975	COG0494	nUDIX hydrolase
CWI35_RS13980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWI35_RS13985	COG1116	anion transmembrane transporter activity
CWI35_RS13990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWI35_RS13995	COG1506	peptidase
CWI35_RS14015	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CWI35_RS14020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CWI35_RS14025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CWI35_RS14035	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CWI35_RS14050	COG2814	Major facilitator Superfamily
CWI35_RS14055	COG0495	leucyl-tRNA aminoacylation
CWI35_RS14060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_RS14095	COG2081	HI0933 family
CWI35_RS14100	COG2244	polysaccharide biosynthetic process
CWI35_RS14110	COG1187	pseudouridine synthase activity
CWI35_RS14115	COG1349	DNA-binding transcription factor activity
CWI35_RS14120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWI35_RS14140	COG1523	belongs to the glycosyl hydrolase 13 family
CWI35_RS14145	COG0510	thiamine kinase activity
CWI35_RS14155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CWI35_RS14160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_RS14170	COG1363	Peptidase, m42
CWI35_RS14175	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CWI35_RS14180	COG4848	Belongs to the UPF0354 family
CWI35_RS14185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWI35_RS14190	COG1674	ftsk spoiiie
CWI35_RS14195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWI35_RS14210	COG3118	belongs to the thioredoxin family
CWI35_RS14215	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CWI35_RS14215	COG1605	Chorismate mutase
CWI35_RS14225	COG0123	including yeast histone deacetylase and acetoin utilization protein
CWI35_RS14230	COG0517	IMP dehydrogenase activity
CWI35_RS14235	COG0454	-acetyltransferase
CWI35_RS14240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWI35_RS14245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWI35_RS14260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CWI35_RS14265	COG2199	diguanylate cyclase activity
CWI35_RS14265	COG2203	Gaf domain
CWI35_RS14270	COG1956	GAF domain-containing protein
CWI35_RS14275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWI35_RS14280	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CWI35_RS14290	COG1104	cysteine desulfurase activity
CWI35_RS14295	COG0301	tRNA thio-modification
CWI35_RS14305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWI35_RS14310	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CWI35_RS14315	COG0616	signal peptide processing
CWI35_RS14320	COG1714	RDD family
CWI35_RS14330	COG3874	Sporulation protein YtfJ
CWI35_RS14335	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CWI35_RS14340	COG0827	DNA restriction-modification system
CWI35_RS14345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CWI35_RS14365	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_RS14370	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS14375	COG1960	acyl-CoA dehydrogenase activity
CWI35_RS14380	COG1024	Enoyl-CoA hydratase
CWI35_RS14385	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_RS14415	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_RS14420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWI35_RS14430	COG2197	response regulator
CWI35_RS14435	COG0521	Mo-molybdopterin cofactor biosynthetic process
CWI35_RS14440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWI35_RS14450	COG0137	argininosuccinate synthase activity
CWI35_RS14455	COG0165	Argininosuccinate lyase
CWI35_RS14460	COG0589	response to stress
CWI35_RS14465	COG1028	Short-chain dehydrogenase reductase Sdr
CWI35_RS14475	COG0006	proline dipeptidase activity
CWI35_RS14480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CWI35_RS14485	COG4109	DRTGG domain
CWI35_RS14495	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CWI35_RS14510	COG0587	DNA-directed DNA polymerase activity
CWI35_RS14520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CWI35_RS14525	COG0825	malonyl-CoA metabolic process
CWI35_RS14530	COG0205	6-phosphofructokinase activity
CWI35_RS14540	COG0628	permease
CWI35_RS14545	COG2707	UPF0756 membrane protein
CWI35_RS14550	COG0372	Belongs to the citrate synthase family
CWI35_RS14555	COG0538	isocitrate dehydrogenase activity
CWI35_RS14560	COG0039	L-malate dehydrogenase activity
CWI35_RS14575	COG0745	RESPONSE REGULATOR receiver
CWI35_RS14580	COG5002	protein histidine kinase activity
CWI35_RS14590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CWI35_RS14595	COG0237	dephospho-CoA kinase activity
CWI35_RS14600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWI35_RS14605	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CWI35_RS14615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CWI35_RS14620	COG3611	Membrane attachment protein
CWI35_RS14625	COG1484	DNA-dependent DNA replication
CWI35_RS14645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CWI35_RS14660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CWI35_RS14665	COG3326	Membrane
CWI35_RS14675	COG1363	Peptidase, m42
CWI35_RS14705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWI35_RS14710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWI35_RS14715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CWI35_RS14720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWI35_RS14720	COG0072	phenylalanine-tRNA ligase activity
CWI35_RS14725	COG1910	domain protein
CWI35_RS14730	COG0725	ABC transporter, periplasmic molybdate-binding protein
CWI35_RS14735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CWI35_RS14740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CWI35_RS14750	COG1785	Belongs to the alkaline phosphatase family
CWI35_RS14755	COG1846	Transcriptional regulator
CWI35_RS14760	COG2409	Drug exporters of the RND superfamily
CWI35_RS14760	COG1033	growth of symbiont in host cell
CWI35_RS14770	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWI35_RS14775	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CWI35_RS14780	COG1286	toxin biosynthetic process
CWI35_RS14785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWI35_RS14785	COG1796	DNA polymerase
CWI35_RS14790	COG1193	negative regulation of DNA recombination
CWI35_RS14795	COG3766	membrane
CWI35_RS14800	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_RS14805	COG1309	transcriptional regulator
CWI35_RS14810	COG1024	Enoyl-CoA hydratase
CWI35_RS14815	COG2086	electron transfer activity
CWI35_RS14820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CWI35_RS14825	COG3118	belongs to the thioredoxin family
CWI35_RS14830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWI35_RS14835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWI35_RS14840	COG1116	anion transmembrane transporter activity
CWI35_RS14845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWI35_RS14850	COG0431	NADPH-dependent FMN reductase
CWI35_RS14855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWI35_RS14865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWI35_RS14880	COG0463	Glycosyl transferase, family 2
CWI35_RS14900	COG0322	excinuclease ABC activity
CWI35_RS14905	COG1719	4-vinyl reductase, 4VR
CWI35_RS14910	COG2009	succinate dehydrogenase
CWI35_RS14915	COG1053	succinate dehydrogenase
CWI35_RS14920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CWI35_RS14925	COG2197	response regulator
CWI35_RS14930	COG1846	Transcriptional regulator
CWI35_RS14935	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CWI35_RS14940	COG5401	PFAM Sporulation and spore germination
CWI35_RS14945	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CWI35_RS14950	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CWI35_RS14955	COG0622	Phosphoesterase
CWI35_RS14960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWI35_RS14970	COG0028	Belongs to the TPP enzyme family
CWI35_RS14975	COG0440	acetolactate synthase activity
CWI35_RS14980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CWI35_RS14985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWI35_RS14990	COG0473	3-isopropylmalate dehydrogenase activity
CWI35_RS14995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWI35_RS15000	COG0066	3-isopropylmalate dehydratase activity
CWI35_RS15010	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWI35_RS15015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CWI35_RS15020	COG0470	DNA polymerase III
CWI35_RS15020	COG1067	ATP-dependent peptidase activity
CWI35_RS15025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CWI35_RS15030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CWI35_RS15040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CWI35_RS15045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CWI35_RS15050	COG0181	hydroxymethylbilane synthase activity
CWI35_RS15055	COG1587	Uroporphyrinogen-III synthase
CWI35_RS15060	COG0113	porphobilinogen synthase activity
CWI35_RS15065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWI35_RS15070	COG1388	LysM domain
CWI35_RS15070	COG1388	LysM domain
CWI35_RS15085	COG0525	valine-tRNA ligase activity
CWI35_RS15090	COG0285	dihydrofolate synthase activity
CWI35_RS15095	COG5492	domain, Protein
CWI35_RS15100	COG3344	reverse transcriptase
CWI35_RS15135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CWI35_RS15145	COG1459	type II secretion system
CWI35_RS15155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CWI35_RS15195	COG0424	maF-like protein
CWI35_RS15200	COG2003	Belongs to the UPF0758 family
CWI35_RS15205	COG1077	Cell shape determining protein MreB Mrl
CWI35_RS15210	COG1792	Involved in formation and maintenance of cell shape
CWI35_RS15220	COG0850	regulation of cytokinetic process
CWI35_RS15225	COG2894	cell division
CWI35_RS15235	COG0739	heme binding
CWI35_RS15240	COG1994	Peptidase M50
CWI35_RS15245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CWI35_RS15250	COG2868	ribosomal protein
CWI35_RS15255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CWI35_RS15260	COG3290	protein histidine kinase activity
CWI35_RS15265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CWI35_RS15270	COG4492	Belongs to the UPF0735 family
CWI35_RS15275	COG0077	Prephenate dehydratase
CWI35_RS15280	COG1827	regulation of RNA biosynthetic process
CWI35_RS15285	COG1104	cysteine desulfurase activity
CWI35_RS15290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CWI35_RS15295	COG0157	Belongs to the NadC ModD family
CWI35_RS15300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CWI35_RS15305	COG1388	LysM domain
CWI35_RS15315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CWI35_RS15325	COG0217	transcriptional regulatory protein
CWI35_RS15335	COG0632	four-way junction helicase activity
CWI35_RS15340	COG2255	four-way junction helicase activity
CWI35_RS15355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CWI35_RS15360	COG0343	queuine tRNA-ribosyltransferase activity
CWI35_RS15365	COG1862	Preprotein translocase
CWI35_RS15375	COG2244	polysaccharide biosynthetic process
CWI35_RS15385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWI35_RS15385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWI35_RS15390	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWI35_RS15395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CWI35_RS15395	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CWI35_RS15400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWI35_RS15405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWI35_RS15410	COG1490	D-aminoacyl-tRNA deacylase activity
CWI35_RS15415	COG0450	alkyl hydroperoxide reductase
CWI35_RS15420	COG3634	alkyl hydroperoxide reductase activity
CWI35_RS15425	COG0124	histidyl-tRNA synthetase
CWI35_RS15430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CWI35_RS15440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CWI35_RS15450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWI35_RS15455	COG1309	transcriptional regulator
CWI35_RS15460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWI35_RS15465	COG2364	Membrane
CWI35_RS15470	COG1959	2 iron, 2 sulfur cluster binding
CWI35_RS15475	COG1104	cysteine desulfurase activity
CWI35_RS15480	COG0482	sulfurtransferase activity
CWI35_RS15490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CWI35_RS15510	COG0628	permease
CWI35_RS15515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CWI35_RS15520	COG4472	Bacterial protein of unknown function (DUF965)
CWI35_RS15525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CWI35_RS15530	COG3906	Belongs to the UPF0473 family
CWI35_RS15535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CWI35_RS15540	COG4122	O-methyltransferase activity
CWI35_RS15545	COG0826	peptidase U32
CWI35_RS15550	COG0826	peptidase U32
CWI35_RS15555	COG0572	uridine kinase
CWI35_RS15560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWI35_RS15565	COG0768	penicillin binding
CWI35_RS15580	COG2226	methyltransferase
CWI35_RS15585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWI35_RS15595	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CWI35_RS15600	COG0626	cystathionine gamma-synthase activity
CWI35_RS15635	COG1396	sequence-specific DNA binding
CWI35_RS15740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CWI35_RS15755	COG0586	Pfam SNARE associated Golgi protein
CWI35_RS15765	COG1360	Flagellar Motor Protein
CWI35_RS15770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CWI35_RS15775	COG1183	phosphatidylcholine synthase activity
CWI35_RS15780	COG0688	phosphatidylethanolamine metabolic process
CWI35_RS15790	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CWI35_RS15795	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CWI35_RS15800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CWI35_RS15805	COG1534	Rna-binding protein
CWI35_RS15810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CWI35_RS15815	COG1713	HD superfamily hydrolase involved in NAD metabolism
CWI35_RS15820	COG0799	negative regulation of ribosome biogenesis
CWI35_RS15825	COG2226	methyltransferase
CWI35_RS15830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWI35_RS15835	COG1555	photosystem II stabilization
CWI35_RS15835	COG1596	polysaccharide export
CWI35_RS15840	COG2131	deaminase
CWI35_RS15845	COG0658	competence protein
CWI35_RS15845	COG2333	competence protein COMEC
CWI35_RS15855	COG1466	dna polymerase III delta subunit
CWI35_RS15860	COG0268	Binds directly to 16S ribosomal RNA
CWI35_RS15865	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CWI35_RS15870	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWI35_RS15885	COG0481	GTPase activity
CWI35_RS15890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWI35_RS15895	COG1420	regulation of RNA biosynthetic process
CWI35_RS15900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWI35_RS15905	COG0443	Heat shock 70 kDa protein
CWI35_RS15910	COG0484	heat shock protein binding
CWI35_RS15915	COG2264	protein methyltransferase activity
CWI35_RS15920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CWI35_RS15925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWI35_RS15930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CWI35_RS15935	COG1283	sodium-dependent phosphate transmembrane transporter activity
CWI35_RS15940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CWI35_RS15945	COG1610	YqeY-like protein
CWI35_RS15960	COG1702	phosphate starvation-inducible protein PhoH
CWI35_RS15965	COG1480	7TM receptor with intracellular HD hydrolase
CWI35_RS15970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CWI35_RS15975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CWI35_RS15980	COG0295	cytidine deaminase activity
CWI35_RS15985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CWI35_RS15995	COG1381	Involved in DNA repair and RecF pathway recombination
CWI35_RS16000	COG0517	IMP dehydrogenase activity
CWI35_RS16005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CWI35_RS16015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CWI35_RS16025	COG2010	Cytochrome c
CWI35_RS16030	COG2384	SAM-dependent methyltransferase
CWI35_RS16035	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CWI35_RS16040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CWI35_RS16055	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CWI35_RS16070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWI35_RS16075	COG1121	(ABC) transporter
CWI35_RS16080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CWI35_RS16085	COG0735	belongs to the Fur family
CWI35_RS16090	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CWI35_RS16095	COG4709	membrane
CWI35_RS16100	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CWI35_RS16105	COG1388	LysM domain
CWI35_RS16115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CWI35_RS16120	COG0573	inorganic phosphate transmembrane transporter activity
CWI35_RS16125	COG0581	inorganic phosphate transmembrane transporter activity
CWI35_RS16130	COG5521	maltodextrose utilization protein MalA
CWI35_RS16145	COG0477	Major facilitator Superfamily
CWI35_RS16150	COG0768	penicillin binding
CWI35_RS16155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CWI35_RS16180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CWI35_RS16195	COG0457	Tetratricopeptide repeat
CWI35_RS16195	COG0705	Rhomboid family
CWI35_RS16205	COG0697	spore germination
CWI35_RS16210	COG4483	Protein conserved in bacteria
CWI35_RS16215	COG1940	carbohydrate kinase activity
CWI35_RS16230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_RS16250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CWI35_RS16255	COG1459	type II secretion system
CWI35_RS16260	COG4537	Required for transformation and DNA binding
CWI35_RS16295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWI35_RS16300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CWI35_RS16305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CWI35_RS16320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CWI35_RS16325	COG0095	Lipoate-protein ligase
CWI35_RS16330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWI35_RS16335	COG1388	LysM domain
CWI35_RS16335	COG3858	chitin binding
CWI35_RS16365	COG1321	iron dependent repressor
CWI35_RS16370	COG1752	Esterase of the alpha-beta hydrolase superfamily
CWI35_RS16380	COG3872	metal-dependent enzyme
CWI35_RS16390	COG0006	proline dipeptidase activity
CWI35_RS16395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWI35_RS16405	COG3854	ATPases associated with a variety of cellular activities
CWI35_RS16445	COG0511	ligase activity, forming carbon-carbon bonds
CWI35_RS16450	COG0439	Biotin carboxylase
CWI35_RS16455	COG1302	Protein conserved in bacteria
CWI35_RS16460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWI35_RS16465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CWI35_RS16470	COG1570	exodeoxyribonuclease VII activity
CWI35_RS16475	COG1722	exodeoxyribonuclease VII activity
CWI35_RS16485	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CWI35_RS16490	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CWI35_RS16495	COG1438	arginine binding
CWI35_RS16500	COG0497	DNA recombination
CWI35_RS16505	COG0750	zinc metalloprotease
CWI35_RS16515	COG3093	addiction module antidote protein HigA
CWI35_RS16520	COG0584	glycerophosphoryl diester phosphodiesterase
CWI35_RS16530	COG3829	transcription factor binding
CWI35_RS16530	COG3290	protein histidine kinase activity
CWI35_RS16535	COG0280	phosphate acetyltransferase
CWI35_RS16545	COG3426	butyrate kinase activity
CWI35_RS16550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWI35_RS16555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CWI35_RS16560	COG0022	dehydrogenase e1 component
CWI35_RS16565	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWI35_RS16575	COG0745	RESPONSE REGULATOR receiver
CWI35_RS16580	COG5002	protein histidine kinase activity
CWI35_RS16600	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CWI35_RS16600	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CWI35_RS16605	COG1703	isobutyryl-CoA mutase activity
CWI35_RS16640	COG1131	(ABC) transporter
CWI35_RS16660	COG1131	(ABC) transporter
CWI35_RS16690	COG4129	membrane
CWI35_RS16695	COG1376	ErfK ybiS ycfS ynhG family protein
CWI35_RS16705	COG0346	lactoylglutathione lyase activity
CWI35_RS16710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CWI35_RS16720	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWI35_RS16735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CWI35_RS16740	COG0577	efflux transmembrane transporter activity
CWI35_RS16745	COG1136	(ABC) transporter
CWI35_RS16750	COG0642	Histidine kinase
CWI35_RS16755	COG0745	RESPONSE REGULATOR receiver
CWI35_RS16775	COG2723	6-phospho-beta-galactosidase activity
CWI35_RS16780	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CWI35_RS16785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CWI35_RS16790	COG1234	tRNA 3'-trailer cleavage
CWI35_RS16795	COG1902	pentaerythritol trinitrate reductase activity
CWI35_RS16800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWI35_RS16805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWI35_RS16810	COG0300	oxidoreductase activity
CWI35_RS16840	COG2807	transmembrane transport
CWI35_RS16845	COG0667	Aldo Keto reductase
CWI35_RS16850	COG0494	nUDIX hydrolase
CWI35_RS16855	COG1379	DNA repair
CWI35_RS16860	COG1300	Membrane
CWI35_RS16865	COG0735	belongs to the Fur family
CWI35_RS16875	COG4974	Belongs to the 'phage' integrase family
CWI35_RS16880	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CWI35_RS16895	COG1686	Belongs to the peptidase S11 family
CWI35_RS16905	COG2172	sigma factor antagonist activity
CWI35_RS16930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CWI35_RS16945	COG0697	spore germination
CWI35_RS16950	COG0019	diaminopimelate decarboxylase activity
CWI35_RS16955	COG4086	secreted protein
CWI35_RS16960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CWI35_RS16965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWI35_RS16965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWI35_RS16970	COG0307	riboflavin synthase, alpha
CWI35_RS16975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWI35_RS16975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWI35_RS16980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CWI35_RS16990	COG1547	Domain of unknown function (DUF309)
CWI35_RS16995	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CWI35_RS17000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CWI35_RS17010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CWI35_RS17015	COG1686	Belongs to the peptidase S11 family
CWI35_RS17020	COG2715	membrane protein required for spore maturation
CWI35_RS17025	COG0700	Nucleoside recognition
CWI35_RS17030	COG1187	pseudouridine synthase activity
CWI35_RS17035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWI35_RS17040	COG1333	cytochrome c biogenesis protein
CWI35_RS17045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CWI35_RS17050	COG0745	RESPONSE REGULATOR receiver
CWI35_RS17055	COG5002	protein histidine kinase activity
CWI35_RS17060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CWI35_RS17065	COG0363	glucosamine-6-phosphate deaminase activity
CWI35_RS17070	COG2188	Transcriptional regulator
CWI35_RS17075	COG1263	PTS System
CWI35_RS17075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWI35_RS17085	COG3275	phosphorelay sensor kinase activity
CWI35_RS17090	COG3279	Response regulator of the LytR AlgR family
CWI35_RS17105	COG0531	amino acid
CWI35_RS17115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CWI35_RS17120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWI35_RS17125	COG1120	ATPase activity
CWI35_RS17130	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CWI35_RS17135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWI35_RS17140	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CWI35_RS17145	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CWI35_RS17160	COG2096	Adenosyltransferase
CWI35_RS17175	COG1595	DNA-templated transcription, initiation
CWI35_RS17185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CWI35_RS17190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWI35_RS17215	COG4955	Helix-turn-helix domain
CWI35_RS17220	COG0514	ATP-dependent DNA helicase (RecQ)
CWI35_RS17240	COG3546	catalase activity
CWI35_RS17260	COG4862	establishment of competence for transformation
CWI35_RS17265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CWI35_RS17270	COG0492	ferredoxin-NADP+ reductase activity
CWI35_RS17280	COG2339	peptidase activity
CWI35_RS17285	COG3409	Peptidoglycan-binding domain 1 protein
CWI35_RS17285	COG3773	Cell wall hydrolase
CWI35_RS17290	COG2959	enzyme of heme biosynthesis
CWI35_RS17310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CWI35_RS17315	COG0204	Acyl-transferase
CWI35_RS17320	COG0539	negative regulation of cytoplasmic translation
CWI35_RS17345	COG1160	GTP binding
CWI35_RS17350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CWI35_RS17365	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CWI35_RS17380	COG0302	gtp cyclohydrolase
CWI35_RS17395	COG2226	methyltransferase
CWI35_RS17405	COG0105	UTP biosynthetic process
CWI35_RS17415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CWI35_RS17420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CWI35_RS17425	COG4401	Chorismate mutase type I
CWI35_RS17435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CWI35_RS17440	COG0134	indole-3-glycerol-phosphate synthase activity
CWI35_RS17445	COG0135	phosphoribosylanthranilate isomerase activity
CWI35_RS17455	COG0159	tryptophan synthase activity
CWI35_RS17460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWI35_RS17465	COG0287	Prephenate dehydrogenase
CWI35_RS17470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CWI35_RS17475	COG0457	Tetratricopeptide repeat
CWI35_RS17480	COG5582	Belongs to the UPF0302 family
CWI35_RS17515	COG4347	Protein of unknown function (DUF1405)
CWI35_RS17525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CWI35_RS17530	COG1694	Mazg nucleotide pyrophosphohydrolase
CWI35_RS17535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CWI35_RS17540	COG1803	Methylglyoxal synthase
CWI35_RS17545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CWI35_RS17550	COG0438	transferase activity, transferring glycosyl groups
CWI35_RS17555	COG0617	tRNA 3'-terminal CCA addition
CWI35_RS17570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CWI35_RS17575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CWI35_RS17580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CWI35_RS17585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWI35_RS17585	COG1199	ATP-dependent helicase activity
CWI35_RS17610	COG0017	Asparaginyl-tRNA synthetase
CWI35_RS17615	COG3935	DnaD domain protein
CWI35_RS17620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CWI35_RS17625	COG4499	WXG100 protein secretion system (Wss), protein YukC
CWI35_RS17625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWI35_RS17630	COG3331	DNA recombination
CWI35_RS17670	COG0745	RESPONSE REGULATOR receiver
CWI35_RS17675	COG5002	protein histidine kinase activity
CWI35_RS17680	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CWI35_RS17685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CWI35_RS17695	COG2217	Heavy metal translocating P-type atpase
CWI35_RS17700	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CWI35_RS17705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CWI35_RS17710	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CWI35_RS17715	COG1609	Transcriptional regulator
CWI35_RS17720	COG0071	Belongs to the small heat shock protein (HSP20) family
CWI35_RS17785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWI35_RS17790	COG2368	4-hydroxyphenylacetate
CWI35_RS17800	COG0318	PFAM AMP-dependent synthetase and ligase
CWI35_RS17820	COG4377	Putative membrane peptidase family (DUF2324)
CWI35_RS17835	COG0156	8-amino-7-oxononanoate synthase activity
CWI35_RS17860	COG2066	Belongs to the glutaminase family
CWI35_RS17875	COG2211	Major facilitator Superfamily
CWI35_RS17895	COG0673	inositol 2-dehydrogenase activity
CWI35_RS17900	COG1012	belongs to the aldehyde dehydrogenase family
CWI35_RS17900	COG2030	dehydratase
CWI35_RS17915	COG1609	Transcriptional regulator
CWI35_RS17920	COG1653	transport
CWI35_RS17935	COG0673	inositol 2-dehydrogenase activity
CWI35_RS17945	COG0673	inositol 2-dehydrogenase activity
CWI35_RS17950	COG1082	Xylose isomerase domain protein TIM barrel
CWI35_RS17975	COG1061	Type III restriction enzyme res subunit
CWI35_RS17980	COG4336	lyase activity
CWI35_RS18000	COG0463	Glycosyl transferase, family 2
CWI35_RS18000	COG0457	Tetratricopeptide repeat
CWI35_RS18025	COG0658	competence protein
CWI35_RS18025	COG2333	competence protein COMEC
CWI35_RS18055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CWI35_RS18090	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CWI35_RS18130	COG1876	peptidase activity
CWI35_RS18135	COG0582	viral genome integration into host DNA