locus-tag	class	description
AK40_RS00210	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AK40_RS00615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK40_RS00815	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AK40_RS01190	COG3852	Histidine kinase
AK40_RS01435	COG2861	carbohydrate metabolic process
AK40_RS01555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK40_RS01555	COG1372	Participates in initiation and elongation during chromosome replication
AK40_RS02505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AK40_RS02560	COG1266	CAAX protease self-immunity
AK40_RS02765	COG0438	transferase activity, transferring glycosyl groups
AK40_RS02790	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AK40_RS02790	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AK40_RS02815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AK40_RS02815	COG1199	ATP-dependent helicase activity
AK40_RS02935	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AK40_RS03000	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK40_RS03035	COG0754	glutathionylspermidine amidase activity
AK40_RS03270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK40_RS03625	COG3874	Sporulation protein YtfJ
AK40_RS03645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK40_RS03695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AK40_RS03750	COG1840	ABC-type Fe3 transport system, periplasmic component
AK40_RS03755	COG3842	ATPase activity
AK40_RS03780	COG1349	DNA-binding transcription factor activity
AK40_RS03795	COG0235	Class ii aldolase
AK40_RS03805	COG2861	carbohydrate metabolic process
AK40_RS03815	COG3852	Histidine kinase
AK40_RS03820	COG1846	Transcriptional regulator
AK40_RS03830	COG2318	DinB family
AK40_RS03840	COG5002	protein histidine kinase activity
AK40_RS03850	COG0720	synthase
AK40_RS03865	COG4873	Protein conserved in bacteria
AK40_RS03905	COG1780	Probably involved in ribonucleotide reductase function
AK40_RS03910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK40_RS03915	COG1403	HNH endonuclease
AK40_RS03920	COG1372	Participates in initiation and elongation during chromosome replication
AK40_RS03920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK40_RS03925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AK40_RS03930	COG1725	Transcriptional regulator
AK40_RS03935	COG1131	(ABC) transporter
AK40_RS03945	COG1131	(ABC) transporter
AK40_RS03950	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK40_RS03965	COG1522	sequence-specific DNA binding
AK40_RS03975	COG1335	isochorismatase
AK40_RS03985	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK40_RS03990	COG2070	2-Nitropropane dioxygenase
AK40_RS03995	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AK40_RS04005	COG1696	Membrane protein involved in D-alanine export
AK40_RS04030	COG0716	FMN binding
AK40_RS04045	COG3173	Aminoglycoside phosphotransferase
AK40_RS04065	COG0534	Mate efflux family protein
AK40_RS04070	COG1968	undecaprenyl-diphosphatase activity
AK40_RS04085	COG1846	Transcriptional regulator
AK40_RS04095	COG1301	dicarboxylic acid transport
AK40_RS04100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK40_RS04105	COG4709	membrane
AK40_RS04110	COG3874	Sporulation protein YtfJ
AK40_RS04140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK40_RS04145	COG0028	Belongs to the TPP enzyme family
AK40_RS04150	COG0440	acetolactate synthase activity
AK40_RS04225	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AK40_RS04235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AK40_RS04240	COG1183	phosphatidylcholine synthase activity
AK40_RS04245	COG1368	sulfuric ester hydrolase activity
AK40_RS04255	COG0019	diaminopimelate decarboxylase activity
AK40_RS04275	COG0529	Catalyzes the synthesis of activated sulfate
AK40_RS04280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AK40_RS04300	COG1648	precorrin-2 dehydrogenase activity
AK40_RS04310	COG0733	neurotransmitter:sodium symporter activity
AK40_RS04330	COG1757	Na H antiporter
AK40_RS04345	COG4758	membrane
AK40_RS04350	COG4585	Histidine kinase
AK40_RS04355	COG2197	response regulator
AK40_RS04365	COG1114	Component of the transport system for branched-chain amino acids
AK40_RS04375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AK40_RS04420	COG0730	response to heat
AK40_RS04425	COG0306	phosphate transporter
AK40_RS04430	COG1392	Phosphate transport regulator
AK40_RS04435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK40_RS04450	COG3852	Histidine kinase
AK40_RS04455	COG1801	Protein of unknown function DUF72
AK40_RS04465	COG0582	viral genome integration into host DNA
AK40_RS04470	COG5002	protein histidine kinase activity
AK40_RS04485	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AK40_RS04485	COG0392	lysyltransferase activity
AK40_RS04500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK40_RS04505	COG1686	Belongs to the peptidase S11 family
AK40_RS04510	COG2715	membrane protein required for spore maturation
AK40_RS04515	COG0700	Nucleoside recognition
AK40_RS04520	COG1187	pseudouridine synthase activity
AK40_RS04530	COG1333	cytochrome c biogenesis protein
AK40_RS04535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AK40_RS04540	COG0745	RESPONSE REGULATOR receiver
AK40_RS04545	COG5002	protein histidine kinase activity
AK40_RS04550	COG2096	Adenosyltransferase
AK40_RS04555	COG4942	peptidase
AK40_RS04565	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AK40_RS04570	COG1141	Ferredoxin
AK40_RS04580	COG0514	ATP-dependent DNA helicase (RecQ)
AK40_RS04585	COG1266	CAAX protease self-immunity
AK40_RS04595	COG1408	metallophosphoesterase
AK40_RS04605	COG4862	establishment of competence for transformation
AK40_RS04610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AK40_RS04630	COG0492	ferredoxin-NADP+ reductase activity
AK40_RS04635	COG0252	asparaginase activity
AK40_RS04705	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK40_RS04720	COG0142	geranyltranstransferase activity
AK40_RS04730	COG0142	geranyltranstransferase activity
AK40_RS04750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AK40_RS04755	COG0457	Tetratricopeptide repeat
AK40_RS04775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AK40_RS04785	COG4347	Protein of unknown function (DUF1405)
AK40_RS04800	COG2738	Putative neutral zinc metallopeptidase
AK40_RS04810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_RS04815	COG1694	Mazg nucleotide pyrophosphohydrolase
AK40_RS04830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AK40_RS04835	COG0438	transferase activity, transferring glycosyl groups
AK40_RS04875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AK40_RS04875	COG1199	ATP-dependent helicase activity
AK40_RS04895	COG3935	DnaD domain protein
AK40_RS04900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AK40_RS04910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK40_RS04910	COG4499	WXG100 protein secretion system (Wss), protein YukC
AK40_RS04960	COG0116	Belongs to the methyltransferase superfamily
AK40_RS04970	COG1199	ATP-dependent helicase activity
AK40_RS04975	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AK40_RS04985	COG3173	Aminoglycoside phosphotransferase
AK40_RS04990	COG0024	Methionine aminopeptidase
AK40_RS05000	COG2233	PERMEase
AK40_RS05005	COG2311	Membrane
AK40_RS05010	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK40_RS05020	COG0456	acetyltransferase
AK40_RS05050	COG0754	glutathionylspermidine amidase activity
AK40_RS05065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK40_RS05080	COG0454	-acetyltransferase
AK40_RS05100	COG0328	RNA-DNA hybrid ribonuclease activity
AK40_RS05135	COG3403	YqcI/YcgG family
AK40_RS05140	COG1280	lysine exporter protein (LysE YggA)
AK40_RS05155	COG3162	membrane
AK40_RS05160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK40_RS05165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK40_RS05195	COG0475	glutathione-regulated potassium exporter activity
AK40_RS05200	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK40_RS05205	COG0789	Transcriptional regulator
AK40_RS05205	COG4978	Transcriptional regulator
AK40_RS05215	COG2323	membrane
AK40_RS05220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AK40_RS05275	COG1923	regulation of RNA biosynthetic process
AK40_RS05285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AK40_RS05290	COG1360	Flagellar Motor Protein
AK40_RS05295	COG2201	protein-glutamate methylesterase activity
AK40_RS05300	COG2198	Histidine kinase
AK40_RS05300	COG0643	Histidine kinase
AK40_RS05305	COG1776	CheC inhibitor of MCP methylation
AK40_RS05305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK40_RS05320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AK40_RS05340	COG1256	bacterial-type flagellum assembly
AK40_RS05345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AK40_RS05350	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AK40_RS05365	COG1815	bacterial-type flagellum-dependent cell motility
AK40_RS05370	COG1558	bacterial-type flagellum-dependent cell motility
AK40_RS05380	COG1766	The M ring may be actively involved in energy transduction
AK40_RS05385	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK40_RS05395	COG1157	protein secretion by the type III secretion system
AK40_RS05430	COG0835	chemotaxis
AK40_RS05430	COG0784	Response regulator, receiver
AK40_RS05440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AK40_RS05450	COG0741	lytic transglycosylase activity
AK40_RS05460	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK40_RS05465	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AK40_RS05465	COG1776	CheC inhibitor of MCP methylation
AK40_RS05475	COG1338	Plays a role in the flagellum-specific transport system
AK40_RS05480	COG1987	bacterial-type flagellum assembly
AK40_RS05490	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AK40_RS05495	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AK40_RS05500	COG1419	protein localization to endoplasmic reticulum
AK40_RS05505	COG4786	Flagellar basal body rod
AK40_RS05510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AK40_RS05545	COG2329	Antibiotic biosynthesis monooxygenase
AK40_RS05570	COG0583	DNA-binding transcription factor activity
AK40_RS05575	COG3842	ATPase activity
AK40_RS05580	COG0725	ABC transporter, periplasmic molybdate-binding protein
AK40_RS05590	COG1234	tRNA 3'-trailer cleavage
AK40_RS05615	COG1686	Belongs to the peptidase S11 family
AK40_RS05625	COG0406	alpha-ribazole phosphatase activity
AK40_RS05645	COG1846	Transcriptional regulator
AK40_RS05655	COG0367	asparagine synthase
AK40_RS05685	COG1802	Transcriptional regulator
AK40_RS05690	COG0697	spore germination
AK40_RS05695	COG0523	cobalamin synthesis protein
AK40_RS05700	COG0701	Predicted permease
AK40_RS05715	COG1757	Na H antiporter
AK40_RS05720	COG0114	fumarate hydratase activity
AK40_RS05740	COG0534	Mate efflux family protein
AK40_RS05745	COG3340	Belongs to the peptidase S51 family
AK40_RS05765	COG0785	Cytochrome C biogenesis protein
AK40_RS05800	COG2733	membrane
AK40_RS05835	COG1131	(ABC) transporter
AK40_RS05850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK40_RS05855	COG0528	UMP kinase activity
AK40_RS05865	COG1027	Aspartate ammonia-lyase
AK40_RS05870	COG0281	malic enzyme
AK40_RS05875	COG4191	Histidine kinase
AK40_RS05880	COG0784	Response regulator, receiver
AK40_RS05885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK40_RS05910	COG3620	sequence-specific DNA binding
AK40_RS05940	COG1051	belongs to the nudix hydrolase family
AK40_RS05965	COG1966	Carbon starvation protein
AK40_RS05975	COG0477	Major facilitator Superfamily
AK40_RS05980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_RS05990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AK40_RS05995	COG4166	transmembrane transport
AK40_RS06000	COG2223	nitrite transmembrane transporter activity
AK40_RS06005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK40_RS06020	COG2244	polysaccharide biosynthetic process
AK40_RS06025	COG0733	neurotransmitter:sodium symporter activity
AK40_RS06035	COG5566	PFAM Mor transcription activator
AK40_RS06040	COG2323	membrane
AK40_RS06055	COG2084	Dehydrogenase
AK40_RS06070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK40_RS06080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK40_RS06085	COG0028	Belongs to the TPP enzyme family
AK40_RS06095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AK40_RS06105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AK40_RS06130	COG2814	Major facilitator Superfamily
AK40_RS06135	COG3384	dioxygenase
AK40_RS06155	COG3279	Response regulator of the LytR AlgR family
AK40_RS06160	COG0427	acetyl-CoA hydrolase
AK40_RS06195	COG4166	transmembrane transport
AK40_RS06220	COG0535	radical SAM domain protein
AK40_RS06225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_RS06230	COG0745	RESPONSE REGULATOR receiver
AK40_RS06250	COG1914	H( )-stimulated, divalent metal cation uptake system
AK40_RS06265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AK40_RS06275	COG0531	amino acid
AK40_RS06320	COG0745	RESPONSE REGULATOR receiver
AK40_RS06325	COG2205	protein histidine kinase activity
AK40_RS06330	COG2390	Transcriptional regulator
AK40_RS06340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_RS06345	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AK40_RS06355	COG4846	Membrane protein involved in cytochrome C biogenesis
AK40_RS06375	COG0006	proline dipeptidase activity
AK40_RS06380	COG2132	Multicopper oxidase
AK40_RS06395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AK40_RS06415	COG1114	Component of the transport system for branched-chain amino acids
AK40_RS06425	COG2372	response to copper ion
AK40_RS06425	COG1276	copper resistance
AK40_RS06430	COG4549	nuclear export factor GLE1
AK40_RS06440	COG0697	spore germination
AK40_RS06445	COG0583	DNA-binding transcription factor activity
AK40_RS06450	COG1959	2 iron, 2 sulfur cluster binding
AK40_RS06455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AK40_RS06460	COG0778	Nitroreductase
AK40_RS06475	COG0628	permease
AK40_RS06485	COG1231	oxidoreductase activity
AK40_RS06490	COG0523	cobalamin synthesis protein
AK40_RS06505	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_RS06510	COG2030	dehydratase
AK40_RS06515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_RS06525	COG0411	ABC transporter
AK40_RS06545	COG0583	DNA-binding transcription factor activity
AK40_RS06575	COG1271	oxidase subunit
AK40_RS06580	COG1294	oxidase, subunit
AK40_RS06585	COG4988	ABC transporter
AK40_RS06590	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AK40_RS06605	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK40_RS06610	COG1686	Belongs to the peptidase S11 family
AK40_RS06625	COG1388	LysM domain
AK40_RS06625	COG0791	NLP P60 protein
AK40_RS06635	COG1132	(ABC) transporter
AK40_RS06640	COG0745	RESPONSE REGULATOR receiver
AK40_RS06645	COG2205	protein histidine kinase activity
AK40_RS06655	COG0300	oxidoreductase activity
AK40_RS06660	COG4122	O-methyltransferase activity
AK40_RS06690	COG0460	homoserine dehydrogenase
AK40_RS06715	COG1316	TRANSCRIPTIONal
AK40_RS06725	COG0745	RESPONSE REGULATOR receiver
AK40_RS06730	COG5002	protein histidine kinase activity
AK40_RS06745	COG1285	pathogenesis
AK40_RS06750	COG1247	-acetyltransferase
AK40_RS06770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AK40_RS06780	COG1082	Xylose isomerase domain protein TIM barrel
AK40_RS06790	COG2814	Major facilitator Superfamily
AK40_RS06795	COG1279	arginine transmembrane transporter activity
AK40_RS06800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_RS06810	COG1752	Esterase of the alpha-beta hydrolase superfamily
AK40_RS06845	COG0577	efflux transmembrane transporter activity
AK40_RS06850	COG2002	toxin-antitoxin pair type II binding
AK40_RS06855	COG1404	Belongs to the peptidase S8 family
AK40_RS06860	COG0640	Transcriptional regulator
AK40_RS06865	COG0667	Aldo Keto reductase
AK40_RS06870	COG2814	Major facilitator Superfamily
AK40_RS06895	COG0840	transmembrane signaling receptor activity
AK40_RS06915	COG3949	Membrane
AK40_RS06920	COG0783	Belongs to the Dps family
AK40_RS06935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AK40_RS06945	COG1231	oxidoreductase activity
AK40_RS06955	COG4989	oxidoreductase activity
AK40_RS06960	COG0523	cobalamin synthesis protein
AK40_RS06965	COG0456	acetyltransferase
AK40_RS06985	COG3443	Belongs to the bacterial solute-binding protein 9 family
AK40_RS06985	COG0803	Belongs to the bacterial solute-binding protein 9 family
AK40_RS06995	COG0702	epimerase
AK40_RS07005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AK40_RS07015	COG4166	transmembrane transport
AK40_RS07030	COG0406	alpha-ribazole phosphatase activity
AK40_RS07040	COG5337	Spore coat protein CotH
AK40_RS07045	COG1051	belongs to the nudix hydrolase family
AK40_RS07050	COG0586	Pfam SNARE associated Golgi protein
AK40_RS07055	COG2244	polysaccharide biosynthetic process
AK40_RS07065	COG0701	Predicted permease
AK40_RS07070	COG3689	TIGRFAM TIGR03943 family protein
AK40_RS07075	COG1607	acyl-coa hydrolase
AK40_RS07080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK40_RS07095	COG0702	epimerase
AK40_RS07100	COG2839	Protein conserved in bacteria
AK40_RS07105	COG1253	flavin adenine dinucleotide binding
AK40_RS07120	COG1114	Component of the transport system for branched-chain amino acids
AK40_RS07125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK40_RS07145	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK40_RS07155	COG1876	peptidase activity
AK40_RS07165	COG0154	amidase activity
AK40_RS07170	COG2211	Major facilitator Superfamily
AK40_RS07185	COG2368	4-hydroxyphenylacetate
AK40_RS07195	COG0196	riboflavin kinase activity
AK40_RS07210	COG0251	oxidation-reduction process
AK40_RS07220	COG3971	2-oxopent-4-enoate hydratase activity
AK40_RS07240	COG1942	4-Oxalocrotonate Tautomerase
AK40_RS07250	COG0561	phosphatase activity
AK40_RS07260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AK40_RS07265	COG4106	trans-aconitate 2-methyltransferase activity
AK40_RS07280	COG1819	glycosyl
AK40_RS07285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_RS07290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_RS07320	COG0456	acetyltransferase
AK40_RS07400	COG3874	Sporulation protein YtfJ
AK40_RS07425	COG2226	methyltransferase
AK40_RS07445	COG1082	Xylose isomerase domain protein TIM barrel
AK40_RS07450	COG0346	lactoylglutathione lyase activity
AK40_RS07465	COG1595	DNA-templated transcription, initiation
AK40_RS07480	COG0426	domain, Protein
AK40_RS07480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AK40_RS07490	COG0386	Belongs to the glutathione peroxidase family
AK40_RS07495	COG1305	Transglutaminase-like
AK40_RS07500	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AK40_RS07505	COG0714	Associated with various cellular activities
AK40_RS07520	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AK40_RS07525	COG1140	nitrate reductase beta subunit
AK40_RS07530	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AK40_RS07535	COG2181	nitrate reductase activity
AK40_RS07540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AK40_RS07545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AK40_RS07550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK40_RS07555	COG0303	'Molybdopterin
AK40_RS07560	COG0314	molybdopterin synthase activity
AK40_RS07570	COG2223	nitrite transmembrane transporter activity
AK40_RS07580	COG1648	precorrin-2 dehydrogenase activity
AK40_RS07590	COG1587	Uroporphyrinogen-III synthase
AK40_RS07590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AK40_RS07595	COG2146	nitrite reductase [NAD(P)H] activity
AK40_RS07600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AK40_RS07605	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AK40_RS07640	COG2359	stage V sporulation protein S
AK40_RS07705	COG1418	mRNA catabolic process
AK40_RS07710	COG0488	(ABC) transporter
AK40_RS07725	COG0629	single-stranded DNA binding
AK40_RS07740	COG1413	lyase activity
AK40_RS07755	COG2136	Putative SAM-dependent methyltransferase
AK40_RS07755	COG2521	methyltransferase
AK40_RS07760	COG0018	arginyl-trna synthetase
AK40_RS07795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AK40_RS07800	COG0017	Asparaginyl-tRNA synthetase
AK40_RS07820	COG1674	ftsk spoiiie
AK40_RS07935	COG1929	Belongs to the glycerate kinase type-1 family
AK40_RS07940	COG0471	metal ion transport
AK40_RS07945	COG0745	RESPONSE REGULATOR receiver
AK40_RS07950	COG3850	Histidine kinase
AK40_RS07950	COG5002	protein histidine kinase activity
AK40_RS07965	COG0733	neurotransmitter:sodium symporter activity
AK40_RS07990	COG2610	gluconate transmembrane transporter activity
AK40_RS07995	COG1454	alcohol dehydrogenase
AK40_RS08000	COG1794	racemase activity, acting on amino acids and derivatives
AK40_RS08010	COG0456	acetyltransferase
AK40_RS08015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AK40_RS08025	COG1131	(ABC) transporter
AK40_RS08030	COG4473	ABC transporter
AK40_RS08040	COG0546	phosphoglycolate phosphatase activity
AK40_RS08060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK40_RS08065	COG3250	beta-galactosidase activity
AK40_RS08080	COG0768	penicillin binding
AK40_RS08090	COG0204	Acyl-transferase
AK40_RS08095	COG1272	protein, Hemolysin III
AK40_RS08105	COG0805	protein transport
AK40_RS08115	COG1307	EDD domain protein, DegV family
AK40_RS08120	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AK40_RS08125	COG1999	signal sequence binding
AK40_RS08130	COG0071	Belongs to the small heat shock protein (HSP20) family
AK40_RS08135	COG0367	asparagine synthase
AK40_RS08155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_RS08160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK40_RS08180	COG1335	isochorismatase
AK40_RS08185	COG1051	belongs to the nudix hydrolase family
AK40_RS08195	COG0668	transmembrane transport
AK40_RS08200	COG4585	Histidine kinase
AK40_RS08200	COG2203	Gaf domain
AK40_RS08205	COG2197	response regulator
AK40_RS08210	COG1737	Transcriptional regulator
AK40_RS08215	COG1064	alcohol dehydrogenase
AK40_RS08270	COG0517	IMP dehydrogenase activity
AK40_RS08270	COG1125	glycine betaine transport
AK40_RS08275	COG1174	glycine betaine transport
AK40_RS08310	COG1253	flavin adenine dinucleotide binding
AK40_RS08315	COG1012	belongs to the aldehyde dehydrogenase family
AK40_RS08320	COG5506	Protein of unknown function (DUF1694)
AK40_RS08335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK40_RS08340	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AK40_RS08345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AK40_RS08350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK40_RS08355	COG0456	acetyltransferase
AK40_RS08360	COG3829	transcription factor binding
AK40_RS08365	COG1509	lysine 2,3-aminomutase activity
AK40_RS08400	COG0515	serine threonine protein kinase
AK40_RS08400	COG3064	Membrane
AK40_RS08400	COG4991	sh3 domain protein
AK40_RS08405	COG4326	sporulation control protein
AK40_RS08410	COG0671	phosphoesterase, PA-phosphatase related
AK40_RS08415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AK40_RS08420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK40_RS08485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK40_RS08520	COG0300	oxidoreductase activity
AK40_RS08540	COG4499	WXG100 protein secretion system (Wss), protein YukC
AK40_RS08540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK40_RS08550	COG2814	Major facilitator Superfamily
AK40_RS08555	COG4841	protein insertion into membrane
AK40_RS08560	COG0372	Belongs to the citrate synthase family
AK40_RS08565	COG2079	MmgE PrpD family protein
AK40_RS08570	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AK40_RS08575	COG1960	acyl-CoA dehydrogenase activity
AK40_RS08580	COG2084	Dehydrogenase
AK40_RS08590	COG1280	lysine exporter protein (LysE YggA)
AK40_RS08595	COG1024	Enoyl-CoA hydratase
AK40_RS08610	COG0420	3'-5' exonuclease activity
AK40_RS08655	COG2223	nitrite transmembrane transporter activity
AK40_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS08665	COG1169	isochorismate synthase
AK40_RS08670	COG1021	2,3-dihydroxybenzoate-AMP ligase
AK40_RS08675	COG3433	isochorismatase activity
AK40_RS08675	COG1535	isochorismatase
AK40_RS08680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AK40_RS08685	COG3251	PFAM MbtH domain protein
AK40_RS08690	COG2814	Major facilitator Superfamily
AK40_RS08705	COG0776	regulation of translation
AK40_RS08715	COG2318	DinB family
AK40_RS08725	COG1115	amino acid carrier protein
AK40_RS08745	COG2329	Antibiotic biosynthesis monooxygenase
AK40_RS08750	COG1187	pseudouridine synthase activity
AK40_RS08755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AK40_RS08765	COG1136	(ABC) transporter
AK40_RS08780	COG0596	Alpha beta hydrolase
AK40_RS08785	COG2814	Major facilitator Superfamily
AK40_RS08805	COG2226	methyltransferase
AK40_RS08850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_RS08885	COG1247	-acetyltransferase
AK40_RS08915	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AK40_RS08925	COG2226	methyltransferase
AK40_RS08930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_RS08940	COG1278	Cold shock
AK40_RS08955	COG0010	Belongs to the arginase family
AK40_RS08965	COG0583	DNA-binding transcription factor activity
AK40_RS08970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AK40_RS08985	COG0583	DNA-binding transcription factor activity
AK40_RS08990	COG2258	MOSC domain
AK40_RS09005	COG1132	(ABC) transporter
AK40_RS09010	COG1132	(ABC) transporter
AK40_RS09025	COG1280	lysine exporter protein (LysE YggA)
AK40_RS09030	COG1396	sequence-specific DNA binding
AK40_RS09060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AK40_RS09070	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AK40_RS09075	COG1595	DNA-templated transcription, initiation
AK40_RS09100	COG1649	PFAM Uncharacterised BCR, COG1649
AK40_RS09125	COG2971	BadF BadG BcrA BcrD
AK40_RS09135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AK40_RS09175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_RS09205	COG1309	transcriptional regulator
AK40_RS09220	COG1136	(ABC) transporter
AK40_RS09220	COG0577	efflux transmembrane transporter activity
AK40_RS09225	COG3615	Tellurite resistance protein tehB
AK40_RS09225	COG0500	methyltransferase
AK40_RS09240	COG0582	viral genome integration into host DNA
AK40_RS09325	COG1846	Transcriptional regulator
AK40_RS09365	COG2195	Cleaves the N-terminal amino acid of tripeptides
AK40_RS09375	COG0110	maltose O-acetyltransferase activity
AK40_RS09390	COG0768	penicillin binding
AK40_RS09395	COG1595	DNA-templated transcription, initiation
AK40_RS09405	COG0768	penicillin binding
AK40_RS09410	COG0768	penicillin binding
AK40_RS09415	COG2367	Beta-lactamase
AK40_RS09425	COG1609	Transcriptional regulator
AK40_RS09430	COG2814	Major facilitator Superfamily
AK40_RS09435	COG0673	inositol 2-dehydrogenase activity
AK40_RS09465	COG3718	enzyme involved in inositol metabolism
AK40_RS09485	COG0737	Belongs to the 5'-nucleotidase family
AK40_RS09495	COG0457	Tetratricopeptide repeat
AK40_RS09500	COG1476	TRANSCRIPTIONal
AK40_RS09515	COG1876	peptidase activity
AK40_RS09535	COG1309	transcriptional regulator
AK40_RS09540	COG0488	(ABC) transporter
AK40_RS09545	COG3300	MHYT domain
AK40_RS09545	COG5001	Diguanylate cyclase
AK40_RS09550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_RS09575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_RS09600	COG1960	acyl-CoA dehydrogenase activity
AK40_RS09605	COG0439	Biotin carboxylase
AK40_RS09610	COG0511	ligase activity, forming carbon-carbon bonds
AK40_RS09615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AK40_RS09620	COG1024	Enoyl-CoA hydratase
AK40_RS09625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AK40_RS09630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AK40_RS09645	COG0572	uridine kinase
AK40_RS09655	COG2318	DinB family
AK40_RS09660	COG1686	Belongs to the peptidase S11 family
AK40_RS09685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AK40_RS09705	COG3227	Zinc metalloprotease (Elastase)
AK40_RS09725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK40_RS09725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK40_RS09760	COG2226	methyltransferase
AK40_RS09775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK40_RS09795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_RS09835	COG3386	PFAM SMP-30 Gluconolaconase
AK40_RS09845	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AK40_RS09850	COG3773	Cell wall hydrolase
AK40_RS09860	COG0745	RESPONSE REGULATOR receiver
AK40_RS09865	COG2205	protein histidine kinase activity
AK40_RS09875	COG0488	(ABC) transporter
AK40_RS09890	COG1136	(ABC) transporter
AK40_RS09895	COG0577	efflux transmembrane transporter activity
AK40_RS09915	COG0460	homoserine dehydrogenase
AK40_RS09920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_RS09930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AK40_RS10020	COG2124	cytochrome p450
AK40_RS10055	COG0561	phosphatase activity
AK40_RS10060	COG5002	protein histidine kinase activity
AK40_RS10065	COG0768	penicillin binding
AK40_RS10070	COG1819	glycosyl
AK40_RS10075	COG1794	racemase activity, acting on amino acids and derivatives
AK40_RS10095	COG2205	protein histidine kinase activity
AK40_RS10105	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK40_RS10110	COG0604	alcohol dehydrogenase
AK40_RS10115	COG0671	phosphoesterase, PA-phosphatase related
AK40_RS10120	COG0768	penicillin binding
AK40_RS10130	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS10140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK40_RS10180	COG0693	protein deglycase activity
AK40_RS10185	COG0456	acetyltransferase
AK40_RS10200	COG2814	Major facilitator Superfamily
AK40_RS10215	COG0584	glycerophosphoryl diester phosphodiesterase
AK40_RS10235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_RS10240	COG0697	spore germination
AK40_RS10265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK40_RS10275	COG2223	nitrite transmembrane transporter activity
AK40_RS10280	COG2816	NAD+ diphosphatase activity
AK40_RS10285	COG0592	DNA-directed DNA polymerase activity
AK40_RS10290	COG1051	belongs to the nudix hydrolase family
AK40_RS10315	COG0406	alpha-ribazole phosphatase activity
AK40_RS10325	COG3878	Protein conserved in bacteria
AK40_RS10350	COG4667	esterase of the alpha-beta hydrolase superfamily
AK40_RS10375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AK40_RS10390	COG0322	excinuclease ABC activity
AK40_RS10425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK40_RS10445	COG1011	Hydrolase
AK40_RS10465	COG1523	belongs to the glycosyl hydrolase 13 family
AK40_RS10470	COG3227	Zinc metalloprotease (Elastase)
AK40_RS10490	COG0346	lactoylglutathione lyase activity
AK40_RS10495	COG0201	protein transport
AK40_RS10505	COG0697	spore germination
AK40_RS10510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_RS10545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_RS10560	COG2959	enzyme of heme biosynthesis
AK40_RS10595	COG1309	transcriptional regulator
AK40_RS10620	COG3284	Transcriptional regulator
AK40_RS10640	COG1349	DNA-binding transcription factor activity
AK40_RS10660	COG1959	2 iron, 2 sulfur cluster binding
AK40_RS10675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AK40_RS10680	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK40_RS10685	COG0022	dehydrogenase e1 component
AK40_RS10690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK40_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS10705	COG0456	acetyltransferase
AK40_RS10705	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK40_RS10710	COG0572	uridine kinase
AK40_RS10720	COG0494	nUDIX hydrolase
AK40_RS10745	COG4176	ABC-type proline glycine betaine transport system permease component
AK40_RS10750	COG0517	IMP dehydrogenase activity
AK40_RS10750	COG4175	Glycine betaine
AK40_RS10775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AK40_RS10780	COG2153	protein acetylation
AK40_RS10785	COG3397	chitin binding
AK40_RS10795	COG2205	protein histidine kinase activity
AK40_RS10800	COG2226	methyltransferase
AK40_RS10805	COG2315	Protein conserved in bacteria
AK40_RS10810	COG2153	protein acetylation
AK40_RS10815	COG2333	competence protein COMEC
AK40_RS10815	COG0658	competence protein
AK40_RS10865	COG3973	AAA domain
AK40_RS10880	COG2105	PFAM AIG2 family protein
AK40_RS10885	COG0514	ATP-dependent DNA helicase (RecQ)
AK40_RS10915	COG4637	Psort location Cytoplasmic, score
AK40_RS10940	COG3397	chitin binding
AK40_RS10950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AK40_RS10955	COG1115	amino acid carrier protein
AK40_RS10960	COG1012	belongs to the aldehyde dehydrogenase family
AK40_RS10965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AK40_RS10975	COG3938	Belongs to the proline racemase family
AK40_RS10980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK40_RS11020	COG0586	Pfam SNARE associated Golgi protein
AK40_RS11035	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AK40_RS11040	COG0519	Catalyzes the synthesis of GMP from XMP
AK40_RS11045	COG4166	transmembrane transport
AK40_RS11055	COG4948	Mandelate Racemase Muconate Lactonizing
AK40_RS11095	COG2936	dipeptidyl-peptidase activity
AK40_RS11100	COG5002	protein histidine kinase activity
AK40_RS11105	COG0745	RESPONSE REGULATOR receiver
AK40_RS11135	COG1164	Oligoendopeptidase f
AK40_RS11140	COG0531	amino acid
AK40_RS11145	COG1522	sequence-specific DNA binding
AK40_RS11150	COG1307	EDD domain protein, DegV family
AK40_RS11185	COG2814	Major facilitator Superfamily
AK40_RS11195	COG1664	Polymer-forming cytoskeletal
AK40_RS11200	COG0789	Transcriptional regulator
AK40_RS11205	COG4533	DNA binding
AK40_RS11210	COG0477	Major facilitator Superfamily
AK40_RS11210	COG2814	Major facilitator Superfamily
AK40_RS11230	COG2261	transglycosylase associated protein
AK40_RS11245	COG2226	methyltransferase
AK40_RS11275	COG0436	Aminotransferase
AK40_RS11280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AK40_RS11285	COG5146	pantothenate kinase activity
AK40_RS11290	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AK40_RS11305	COG1131	(ABC) transporter
AK40_RS11360	COG0628	permease
AK40_RS11375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AK40_RS11380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK40_RS11385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK40_RS11400	COG2816	NAD+ diphosphatase activity
AK40_RS11420	COG2746	aminoglycoside 3-N-acetyltransferase activity
AK40_RS11445	COG0697	spore germination
AK40_RS11450	COG2318	DinB family
AK40_RS11490	COG0861	Integral membrane protein TerC family
AK40_RS11495	COG1368	sulfuric ester hydrolase activity
AK40_RS11500	COG0488	(ABC) transporter
AK40_RS11510	COG1033	growth of symbiont in host cell
AK40_RS11510	COG2409	Drug exporters of the RND superfamily
AK40_RS11515	COG1309	transcriptional regulator
AK40_RS11530	COG0287	Prephenate dehydrogenase
AK40_RS11535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AK40_RS11545	COG1605	Chorismate mutase
AK40_RS11545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AK40_RS11585	COG3584	3D domain protein
AK40_RS11585	COG1388	LysM domain
AK40_RS11595	COG2610	gluconate transmembrane transporter activity
AK40_RS11600	COG1024	Enoyl-CoA hydratase
AK40_RS11610	COG3829	transcription factor binding
AK40_RS11610	COG3290	protein histidine kinase activity
AK40_RS11630	COG1172	Belongs to the binding-protein-dependent transport system permease family
AK40_RS11635	COG1172	Belongs to the binding-protein-dependent transport system permease family
AK40_RS11645	COG2390	Transcriptional regulator
AK40_RS11650	COG1070	Carbohydrate kinase
AK40_RS11685	COG2329	Antibiotic biosynthesis monooxygenase
AK40_RS11705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_RS11720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK40_RS11725	COG4187	Peptidase family M20/M25/M40
AK40_RS11730	COG1414	Transcriptional regulator
AK40_RS11735	COG0833	amino acid
AK40_RS11740	COG1690	Belongs to the RtcB family
AK40_RS11745	COG3239	Fatty acid desaturase
AK40_RS11750	COG1785	Belongs to the alkaline phosphatase family
AK40_RS11760	COG3655	Transcriptional regulator
AK40_RS11775	COG4377	Putative membrane peptidase family (DUF2324)
AK40_RS11785	COG3279	Response regulator of the LytR AlgR family
AK40_RS11795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_RS11800	COG0346	lactoylglutathione lyase activity
AK40_RS11820	COG0714	Associated with various cellular activities
AK40_RS11845	COG0463	Glycosyl transferase, family 2
AK40_RS11870	COG0463	Glycosyl transferase, family 2
AK40_RS11880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AK40_RS11885	COG0753	catalase activity
AK40_RS11895	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AK40_RS11925	COG0778	Nitroreductase
AK40_RS11930	COG1846	Transcriptional regulator
AK40_RS11965	COG1725	Transcriptional regulator
AK40_RS11980	COG0577	efflux transmembrane transporter activity
AK40_RS11980	COG1136	(ABC) transporter
AK40_RS12005	COG2207	Transcriptional regulator
AK40_RS12010	COG0456	acetyltransferase
AK40_RS12030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_RS12070	COG0730	response to heat
AK40_RS12080	COG0833	amino acid
AK40_RS12090	COG4335	DNA alkylation repair
AK40_RS12120	COG0768	penicillin binding
AK40_RS12125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AK40_RS12150	COG1984	allophanate hydrolase subunit 2
AK40_RS12155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AK40_RS12160	COG1414	Transcriptional regulator
AK40_RS12175	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK40_RS12180	COG0640	Transcriptional regulator
AK40_RS12190	COG1960	acyl-CoA dehydrogenase activity
AK40_RS12210	COG3314	Sporulation integral membrane protein YlbJ
AK40_RS12240	COG3848	Pyruvate phosphate dikinase
AK40_RS12240	COG0574	Belongs to the PEP-utilizing enzyme family
AK40_RS12245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_RS12260	COG5577	PFAM Coat F domain
AK40_RS12265	COG3403	YqcI/YcgG family
AK40_RS12270	COG1280	lysine exporter protein (LysE YggA)
AK40_RS12275	COG1113	amino acid transport
AK40_RS12305	COG1063	alcohol dehydrogenase
AK40_RS12315	COG1027	Aspartate ammonia-lyase
AK40_RS12320	COG0252	asparaginase activity
AK40_RS12325	COG1396	sequence-specific DNA binding
AK40_RS12350	COG5002	protein histidine kinase activity
AK40_RS12375	COG2207	Transcriptional regulator
AK40_RS12390	COG0322	excinuclease ABC activity
AK40_RS12395	COG0531	amino acid
AK40_RS12400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK40_RS12405	COG0784	Response regulator, receiver
AK40_RS12410	COG4191	Histidine kinase
AK40_RS12415	COG2066	Belongs to the glutaminase family
AK40_RS12420	COG1115	amino acid carrier protein
AK40_RS12455	COG0737	Belongs to the 5'-nucleotidase family
AK40_RS12460	COG2329	Antibiotic biosynthesis monooxygenase
AK40_RS12480	COG0598	Magnesium transport protein CorA
AK40_RS12515	COG0415	Belongs to the DNA photolyase family
AK40_RS12555	COG2814	Major facilitator Superfamily
AK40_RS12565	COG0657	acetylesterase activity
AK40_RS12570	COG0288	reversible hydration of carbon dioxide
AK40_RS12580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AK40_RS12585	COG5609	conserved protein (DUF2294)
AK40_RS12600	COG0714	Associated with various cellular activities
AK40_RS12605	COG1575	Belongs to the MenA family. Type 1 subfamily
AK40_RS12610	COG2267	carboxylic ester hydrolase activity
AK40_RS12615	COG4641	Protein conserved in bacteria
AK40_RS12620	COG1136	(ABC) transporter
AK40_RS12625	COG0577	efflux transmembrane transporter activity
AK40_RS12640	COG0803	Belongs to the bacterial solute-binding protein 9 family
AK40_RS12645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AK40_RS12650	COG1121	(ABC) transporter
AK40_RS12675	COG0798	PFAM Bile acid sodium symporter
AK40_RS12680	COG0346	lactoylglutathione lyase activity
AK40_RS12685	COG0640	Transcriptional regulator
AK40_RS12700	COG0443	Heat shock 70 kDa protein
AK40_RS12720	COG0346	lactoylglutathione lyase activity
AK40_RS12755	COG2814	Major facilitator Superfamily
AK40_RS12780	COG0745	RESPONSE REGULATOR receiver
AK40_RS12785	COG3850	Histidine kinase
AK40_RS12785	COG5002	protein histidine kinase activity
AK40_RS12815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AK40_RS12840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_RS12845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK40_RS12855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_RS12870	COG2309	aminopeptidase activity
AK40_RS12880	COG0789	Transcriptional regulator
AK40_RS12885	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AK40_RS12905	COG0577	efflux transmembrane transporter activity
AK40_RS12925	COG3850	Histidine kinase
AK40_RS12925	COG5002	protein histidine kinase activity
AK40_RS12935	COG2364	Membrane
AK40_RS12940	COG1846	Transcriptional regulator
AK40_RS12945	COG0456	acetyltransferase
AK40_RS12950	COG2808	Putative FMN-binding domain
AK40_RS12955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_RS12970	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK40_RS12985	COG1252	NADH dehydrogenase
AK40_RS12990	COG3227	Zinc metalloprotease (Elastase)
AK40_RS12995	COG0584	glycerophosphoryl diester phosphodiesterase
AK40_RS13030	COG0738	Major facilitator superfamily
AK40_RS13035	COG0673	inositol 2-dehydrogenase activity
AK40_RS13040	COG0561	phosphatase activity
AK40_RS13045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AK40_RS13050	COG1609	Transcriptional regulator
AK40_RS13055	COG0457	Tetratricopeptide repeat
AK40_RS13085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK40_RS13140	COG0814	amino acid
AK40_RS13145	COG1760	l-serine dehydratase
AK40_RS13150	COG1760	l-serine dehydratase
AK40_RS13155	COG2184	nucleotidyltransferase activity
AK40_RS13160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AK40_RS13165	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AK40_RS13175	COG1335	isochorismatase
AK40_RS13180	COG1522	sequence-specific DNA binding
AK40_RS13185	COG0531	amino acid
AK40_RS13200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AK40_RS13220	COG0662	Cupin 2, conserved barrel domain protein
AK40_RS13225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_RS13225	COG2207	Transcriptional regulator
AK40_RS13255	COG3409	Peptidoglycan-binding domain 1 protein
AK40_RS13255	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK40_RS13295	COG0477	Major facilitator Superfamily
AK40_RS13305	COG1846	Transcriptional regulator
AK40_RS13310	COG2814	Major facilitator Superfamily
AK40_RS13325	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK40_RS13330	COG1131	(ABC) transporter
AK40_RS13350	COG2076	Multidrug Resistance protein
AK40_RS13355	COG1309	transcriptional regulator
AK40_RS13375	COG2031	fatty acid transporter
AK40_RS13385	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK40_RS13420	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AK40_RS13435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AK40_RS13440	COG1288	antiporter activity
AK40_RS13465	COG0789	Transcriptional regulator
AK40_RS13485	COG0803	Belongs to the bacterial solute-binding protein 9 family
AK40_RS13490	COG3443	Belongs to the bacterial solute-binding protein 9 family
AK40_RS13495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_RS13500	COG0506	proline dehydrogenase activity
AK40_RS13510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AK40_RS13520	COG2197	response regulator
AK40_RS13540	COG1733	regulation of RNA biosynthetic process
AK40_RS13545	COG0778	Nitroreductase
AK40_RS13565	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS13575	COG1131	(ABC) transporter
AK40_RS13600	COG1011	Hydrolase
AK40_RS13625	COG2365	Tyrosine phosphatase family
AK40_RS13645	COG0346	lactoylglutathione lyase activity
AK40_RS13650	COG1940	carbohydrate kinase activity
AK40_RS13655	COG0738	Major facilitator superfamily
AK40_RS13660	COG0110	maltose O-acetyltransferase activity
AK40_RS13670	COG0577	efflux transmembrane transporter activity
AK40_RS13670	COG1136	(ABC) transporter
AK40_RS13685	COG0628	permease
AK40_RS13705	COG2226	methyltransferase
AK40_RS13715	COG0477	Major facilitator Superfamily
AK40_RS13745	COG1253	flavin adenine dinucleotide binding
AK40_RS13750	COG0789	Transcriptional regulator
AK40_RS13755	COG0697	spore germination
AK40_RS13760	COG1357	PFAM Pentapeptide repeats (8 copies)
AK40_RS13765	COG3813	Protein conserved in bacteria
AK40_RS13770	COG2706	6-phosphogluconolactonase activity
AK40_RS13775	COG1070	Carbohydrate kinase
AK40_RS13785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AK40_RS13790	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AK40_RS13800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AK40_RS13820	COG0814	amino acid
AK40_RS13845	COG1393	Belongs to the ArsC family
AK40_RS13855	COG2188	Transcriptional regulator
AK40_RS13860	COG0673	inositol 2-dehydrogenase activity
AK40_RS13875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_RS13895	COG0384	phenazine biosynthesis protein PhzF
AK40_RS13920	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_RS13925	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK40_RS13930	COG1733	regulation of RNA biosynthetic process
AK40_RS13960	COG1191	sigma factor activity
AK40_RS13965	COG1266	CAAX protease self-immunity
AK40_RS13970	COG1309	transcriptional regulator
AK40_RS13990	COG3152	Membrane
AK40_RS14035	COG1151	hydroxylamine reductase activity
AK40_RS14045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_RS14050	COG3757	hydrolase, family 25
AK40_RS14050	COG3409	Peptidoglycan-binding domain 1 protein
AK40_RS14085	COG2072	flavoprotein involved in K transport
AK40_RS14125	COG1113	amino acid transport
AK40_RS14130	COG2814	Major facilitator Superfamily
AK40_RS14160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AK40_RS14165	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK40_RS14180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_RS14185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_RS14190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_RS14195	COG3739	integral membrane protein
AK40_RS14200	COG0384	phenazine biosynthesis protein PhzF
AK40_RS14220	COG0583	DNA-binding transcription factor activity
AK40_RS14240	COG1193	negative regulation of DNA recombination
AK40_RS14260	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AK40_RS14265	COG1164	Oligoendopeptidase f
AK40_RS14270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK40_RS14300	COG0584	glycerophosphoryl diester phosphodiesterase
AK40_RS14325	COG0640	Transcriptional regulator
AK40_RS14330	COG0604	alcohol dehydrogenase
AK40_RS14340	COG0457	Tetratricopeptide repeat
AK40_RS14345	COG2808	Putative FMN-binding domain
AK40_RS14350	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK40_RS14360	COG0385	Bile acid
AK40_RS14365	COG0277	FAD linked oxidase domain protein
AK40_RS14400	COG1216	Glycosyl transferase, family 2
AK40_RS14405	COG1024	Enoyl-CoA hydratase
AK40_RS14415	COG1285	pathogenesis
AK40_RS14425	COG2514	catechol 2,3-dioxygenase activity
AK40_RS14430	COG2720	vancomycin resistance protein
AK40_RS14470	COG0716	FMN binding
AK40_RS14500	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS14510	COG0165	Argininosuccinate lyase
AK40_RS14525	COG4145	pantothenate transmembrane transporter activity
AK40_RS14535	COG1012	belongs to the aldehyde dehydrogenase family
AK40_RS14540	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS14550	COG1657	PFAM Prenyltransferase squalene oxidase
AK40_RS14555	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AK40_RS14560	COG2962	Rard protein
AK40_RS14565	COG3326	Membrane
AK40_RS14580	COG0489	protein tyrosine kinase activity
AK40_RS14590	COG0314	molybdopterin synthase activity
AK40_RS14595	COG0303	'Molybdopterin
AK40_RS14600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK40_RS14605	COG2116	formate transmembrane transporter activity
AK40_RS14615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AK40_RS14620	COG5609	conserved protein (DUF2294)
AK40_RS14625	COG2427	Protein of unknown function (DUF1641)
AK40_RS14630	COG3383	formate dehydrogenase (NAD+) activity
AK40_RS14640	COG0697	spore germination
AK40_RS14680	COG2226	methyltransferase
AK40_RS14685	COG4166	transmembrane transport
AK40_RS14690	COG4166	transmembrane transport
AK40_RS14695	COG4166	transmembrane transport
AK40_RS14700	COG1301	dicarboxylic acid transport
AK40_RS14705	COG1316	TRANSCRIPTIONal
AK40_RS14715	COG1595	DNA-templated transcription, initiation
AK40_RS14740	COG1131	(ABC) transporter
AK40_RS14750	COG0673	inositol 2-dehydrogenase activity
AK40_RS14760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AK40_RS14765	COG0187	DNA topoisomerase II activity
AK40_RS14775	COG1832	CoA-binding protein
AK40_RS14780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK40_RS14785	COG0745	RESPONSE REGULATOR receiver
AK40_RS14805	COG4841	protein insertion into membrane
AK40_RS14810	COG0824	Thioesterase
AK40_RS14840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK40_RS14850	COG1132	(ABC) transporter
AK40_RS14880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AK40_RS14910	COG2211	Major facilitator Superfamily
AK40_RS14920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AK40_RS14935	COG0183	Belongs to the thiolase family
AK40_RS14940	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_RS14945	COG1268	BioY protein
AK40_RS14950	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_RS14960	COG1122	ATPase activity
AK40_RS15000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_RS15010	COG5002	protein histidine kinase activity
AK40_RS15015	COG0400	carboxylic ester hydrolase activity
AK40_RS15020	COG0346	lactoylglutathione lyase activity
AK40_RS15025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK40_RS15030	COG0069	glutamate synthase activity
AK40_RS15035	COG1902	pentaerythritol trinitrate reductase activity
AK40_RS15040	COG1329	Transcriptional regulator
AK40_RS15045	COG0010	Belongs to the arginase family
AK40_RS15070	COG2226	methyltransferase
AK40_RS15115	COG4846	Membrane protein involved in cytochrome C biogenesis
AK40_RS15120	COG0785	Cytochrome C biogenesis protein
AK40_RS15130	COG1473	amidohydrolase
AK40_RS15140	COG1131	(ABC) transporter
AK40_RS15150	COG0583	DNA-binding transcription factor activity
AK40_RS15160	COG1346	cytolysis
AK40_RS15175	COG0730	response to heat
AK40_RS15185	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK40_RS15185	COG3409	Peptidoglycan-binding domain 1 protein
AK40_RS15200	COG1132	(ABC) transporter
AK40_RS15205	COG1132	(ABC) transporter
AK40_RS15230	COG3639	organic phosphonate transmembrane transporter activity
AK40_RS15245	COG0737	Belongs to the 5'-nucleotidase family
AK40_RS15255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AK40_RS15275	COG1695	Transcriptional regulator
AK40_RS15280	COG0174	glutamine synthetase
AK40_RS15285	COG0789	Transcriptional regulator
AK40_RS15290	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AK40_RS15295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AK40_RS15300	COG2860	membrane
AK40_RS15310	COG0464	growth
AK40_RS15340	COG1388	LysM domain
AK40_RS15340	COG3584	3D domain protein
AK40_RS15345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AK40_RS15345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK40_RS15345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AK40_RS15350	COG1105	Belongs to the carbohydrate kinase PfkB family
AK40_RS15355	COG1349	DNA-binding transcription factor activity
AK40_RS15360	COG1979	alcohol dehydrogenase
AK40_RS15365	COG2322	membrane
AK40_RS15380	COG1113	amino acid transport
AK40_RS15390	COG1408	metallophosphoesterase
AK40_RS15395	COG2116	formate transmembrane transporter activity
AK40_RS15405	COG2217	Heavy metal translocating P-type atpase
AK40_RS15410	COG2608	mercury ion transmembrane transporter activity
AK40_RS15415	COG1937	Protein conserved in bacteria
AK40_RS15425	COG2819	hydrolase of the alpha beta superfamily
AK40_RS15430	COG1120	ATPase activity
AK40_RS15435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_RS15440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_RS15445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_RS15450	COG0708	Exodeoxyribonuclease III
AK40_RS15455	COG2169	Transcriptional regulator
AK40_RS15460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AK40_RS15465	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AK40_RS15475	COG2364	Membrane
AK40_RS15490	COG2267	carboxylic ester hydrolase activity
AK40_RS15495	COG0346	lactoylglutathione lyase activity
AK40_RS15500	COG5001	Diguanylate cyclase
AK40_RS15500	COG3300	MHYT domain
AK40_RS15555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_RS15570	COG1404	Belongs to the peptidase S8 family
AK40_RS15575	COG3773	Cell wall hydrolase
AK40_RS15585	COG1368	sulfuric ester hydrolase activity
AK40_RS15590	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AK40_RS15600	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AK40_RS15620	COG4550	Control of competence regulator ComK, YlbF/YmcA
AK40_RS15630	COG1013	pyruvate-flavodoxin oxidoreductase activity
AK40_RS15635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AK40_RS15635	COG0674	pyruvate-flavodoxin oxidoreductase activity
AK40_RS15645	COG2359	stage V sporulation protein S
AK40_RS15650	COG1692	metallophosphoesterase
AK40_RS15675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AK40_RS15680	COG1426	Protein conserved in bacteria
AK40_RS15695	COG0300	oxidoreductase activity
AK40_RS15700	COG0612	Peptidase, M16
AK40_RS15705	COG0612	Peptidase, M16
AK40_RS15710	COG1079	Belongs to the binding-protein-dependent transport system permease family
AK40_RS15715	COG4603	Belongs to the binding-protein-dependent transport system permease family
AK40_RS15720	COG3845	ABC transporter
AK40_RS15725	COG1744	ABC transporter substrate-binding protein PnrA-like
AK40_RS15730	COG2188	Transcriptional regulator
AK40_RS15735	COG1674	ftsk spoiiie
AK40_RS15745	COG0740	serine-type endopeptidase activity
AK40_RS15750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK40_RS15765	COG0527	aspartate kinase activity
AK40_RS15770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AK40_RS15775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AK40_RS15780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AK40_RS15785	COG1873	PFAM PRC-barrel domain
AK40_RS15790	COG0612	Peptidase, M16
AK40_RS15795	COG0726	polysaccharide deacetylase
AK40_RS15810	COG0196	riboflavin kinase activity
AK40_RS15825	COG1550	Protein conserved in bacteria
AK40_RS15835	COG1358	cellular component organization or biogenesis
AK40_RS15840	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AK40_RS15845	COG0195	Participates in both transcription termination and antitermination
AK40_RS15880	COG0750	zinc metalloprotease
AK40_RS15890	COG4589	Belongs to the CDS family
AK40_RS15905	COG0528	UMP kinase activity
AK40_RS15935	COG4974	Belongs to the 'phage' integrase family
AK40_RS15945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AK40_RS15950	COG0758	DNA mediated transformation
AK40_RS15955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AK40_RS15995	COG1837	Belongs to the UPF0109 family
AK40_RS16005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AK40_RS16015	COG0552	protein localization to endoplasmic reticulum
AK40_RS16020	COG1196	nuclear chromosome segregation
AK40_RS16030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AK40_RS16035	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS16040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AK40_RS16055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AK40_RS16060	COG1461	Dihydroxyacetone kinase
AK40_RS16065	COG1302	Protein conserved in bacteria
AK40_RS16080	COG1564	THIamine pyrophosphokinase
AK40_RS16085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AK40_RS16090	COG1162	GTPase activity
AK40_RS16095	COG2815	serine threonine protein kinase
AK40_RS16095	COG0515	serine threonine protein kinase
AK40_RS16100	COG0631	protein serine/threonine phosphatase activity
AK40_RS16110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AK40_RS16110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AK40_RS16120	COG0242	peptide deformylase activity
AK40_RS16125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AK40_RS16130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AK40_RS16150	COG1561	YicC-like family, N-terminal region
AK40_RS16155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AK40_RS16165	COG0006	proline dipeptidase activity
AK40_RS16185	COG3069	C4-dicarboxylate transmembrane transporter activity
AK40_RS16250	COG0564	pseudouridine synthase activity
AK40_RS16270	COG3599	regulation of cell shape
AK40_RS16275	COG2302	S4 RNA-binding domain
AK40_RS16280	COG0762	integral membrane protein
AK40_RS16290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AK40_RS16295	COG1496	oxidoreductase activity
AK40_RS16300	COG1873	PFAM PRC-barrel domain
AK40_RS16305	COG1191	sigma factor activity
AK40_RS16310	COG1191	sigma factor activity
AK40_RS16320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AK40_RS16325	COG0849	cell division
AK40_RS16330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AK40_RS16335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AK40_RS16345	COG0772	Belongs to the SEDS family
AK40_RS16360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AK40_RS16365	COG0768	penicillin binding
AK40_RS16370	COG0768	penicillin binding
AK40_RS16375	COG4839	cell division protein FtsL
AK40_RS16390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AK40_RS16405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AK40_RS16410	COG1399	metal-binding, possibly nucleic acid-binding protein
AK40_RS16420	COG3480	Lon protease (S16) C-terminal proteolytic domain
AK40_RS16425	COG1752	Esterase of the alpha-beta hydrolase superfamily
AK40_RS16430	COG3314	Sporulation integral membrane protein YlbJ
AK40_RS16440	COG0742	ribosomal rna small subunit methyltransferase
AK40_RS16455	COG3679	Belongs to the UPF0342 family
AK40_RS16460	COG0406	alpha-ribazole phosphatase activity
AK40_RS16475	COG2340	Cysteine-rich secretory protein family
AK40_RS16490	COG3336	cytochrome c oxidase
AK40_RS16525	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AK40_RS16530	COG0772	Belongs to the SEDS family
AK40_RS16540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AK40_RS16545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AK40_RS16555	COG4896	Protein conserved in bacteria
AK40_RS16570	COG1217	gtp-binding protein TYPA
AK40_RS16580	COG0483	inositol monophosphate 1-phosphatase activity
AK40_RS16600	COG1982	Orn Lys Arg decarboxylase major
AK40_RS16650	COG0022	dehydrogenase e1 component
AK40_RS16655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK40_RS16665	COG0242	peptide deformylase activity
AK40_RS16670	COG0561	phosphatase activity
AK40_RS16680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AK40_RS16685	COG0569	domain protein
AK40_RS16705	COG0583	DNA-binding transcription factor activity
AK40_RS16710	COG0517	IMP dehydrogenase activity
AK40_RS16720	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AK40_RS16730	COG4703	Protein of unknown function (DUF1797)
AK40_RS16745	COG2200	EAL domain
AK40_RS16750	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS16755	COG1408	metallophosphoesterase
AK40_RS16765	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AK40_RS16805	COG2814	Major facilitator Superfamily
AK40_RS16830	COG3209	COG3209 Rhs family protein
AK40_RS16840	COG2205	protein histidine kinase activity
AK40_RS16850	COG0436	Aminotransferase
AK40_RS16855	COG1609	Transcriptional regulator
AK40_RS16860	COG3833	ABC-type maltose transport systems, permease component
AK40_RS16865	COG1175	transmembrane transport
AK40_RS16870	COG2182	Extracellular solute-binding protein
AK40_RS16880	COG0366	Alpha amylase catalytic
AK40_RS16885	COG3842	ATPase activity
AK40_RS16930	COG0183	Belongs to the thiolase family
AK40_RS16965	COG1695	Transcriptional regulator
AK40_RS16970	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS16990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AK40_RS16995	COG0436	Aminotransferase
AK40_RS17030	COG2084	Dehydrogenase
AK40_RS17035	COG2199	diguanylate cyclase activity
AK40_RS17040	COG0778	Nitroreductase
AK40_RS17065	COG1263	PTS System
AK40_RS17065	COG2190	(PTS) system
AK40_RS17065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_RS17070	COG3711	transcriptional antiterminator
AK40_RS17080	COG2188	Transcriptional regulator
AK40_RS17090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AK40_RS17120	COG1547	Domain of unknown function (DUF309)
AK40_RS17125	COG0456	acetyltransferase
AK40_RS17135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AK40_RS17140	COG4086	secreted protein
AK40_RS17145	COG0561	phosphatase activity
AK40_RS17150	COG0697	spore germination
AK40_RS17165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_RS17190	COG0733	neurotransmitter:sodium symporter activity
AK40_RS17210	COG1686	Belongs to the peptidase S11 family
AK40_RS17215	COG1725	Transcriptional regulator
AK40_RS17220	COG1131	(ABC) transporter
AK40_RS17240	COG1846	Transcriptional regulator
AK40_RS17255	COG0598	Magnesium transport protein CorA
AK40_RS17280	COG4974	Belongs to the 'phage' integrase family
AK40_RS17290	COG0735	belongs to the Fur family
AK40_RS17295	COG1300	Membrane
AK40_RS17315	COG0667	Aldo Keto reductase
AK40_RS17320	COG0656	L-ascorbic acid biosynthetic process
AK40_RS17325	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AK40_RS17325	COG0456	acetyltransferase
AK40_RS17335	COG1525	nuclease
AK40_RS17335	COG4085	toxin activity
AK40_RS17335	COG0737	Belongs to the 5'-nucleotidase family
AK40_RS17345	COG0596	Alpha beta hydrolase
AK40_RS17350	COG2056	Na+-H+ antiporter family
AK40_RS17355	COG1609	Transcriptional regulator
AK40_RS17360	COG0456	acetyltransferase
AK40_RS17365	COG1073	alpha beta
AK40_RS17380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AK40_RS17380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AK40_RS17385	COG0307	riboflavin synthase, alpha
AK40_RS17410	COG4106	trans-aconitate 2-methyltransferase activity
AK40_RS17415	COG2226	methyltransferase
AK40_RS17415	COG1073	alpha beta
AK40_RS17430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK40_RS17440	COG1757	Na H antiporter
AK40_RS17445	COG0737	Belongs to the 5'-nucleotidase family
AK40_RS17455	COG1522	sequence-specific DNA binding
AK40_RS17475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AK40_RS17485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AK40_RS17500	COG0300	oxidoreductase activity
AK40_RS17505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_RS17510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK40_RS17515	COG1760	l-serine dehydratase
AK40_RS17520	COG1760	l-serine dehydratase
AK40_RS17540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AK40_RS17550	COG2195	Cleaves the N-terminal amino acid of tripeptides
AK40_RS17555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_RS17570	COG1376	ErfK ybiS ycfS ynhG family protein
AK40_RS17575	COG4129	membrane
AK40_RS17580	COG1126	abc transporter atp-binding protein
AK40_RS17585	COG0765	amino acid transport
AK40_RS17590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK40_RS17610	COG2816	NAD+ diphosphatase activity
AK40_RS17615	COG0772	Belongs to the SEDS family
AK40_RS17625	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK40_RS17630	COG0022	dehydrogenase e1 component
AK40_RS17635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AK40_RS17640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AK40_RS17655	COG0280	phosphate acetyltransferase
AK40_RS17665	COG3829	transcription factor binding
AK40_RS17665	COG3290	protein histidine kinase activity
AK40_RS17675	COG0584	glycerophosphoryl diester phosphodiesterase
AK40_RS17680	COG3093	addiction module antidote protein HigA
AK40_RS17690	COG0745	RESPONSE REGULATOR receiver
AK40_RS17695	COG0750	zinc metalloprotease
AK40_RS17700	COG0497	DNA recombination
AK40_RS17710	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AK40_RS17720	COG0142	geranyltranstransferase activity
AK40_RS17745	COG1302	Protein conserved in bacteria
AK40_RS17750	COG0439	Biotin carboxylase
AK40_RS17755	COG0511	ligase activity, forming carbon-carbon bonds
AK40_RS17800	COG3854	ATPases associated with a variety of cellular activities
AK40_RS17825	COG0006	proline dipeptidase activity
AK40_RS17840	COG3872	metal-dependent enzyme
AK40_RS17850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AK40_RS17865	COG1695	Transcriptional regulator
AK40_RS17880	COG0095	Lipoate-protein ligase
AK40_RS17885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_RS17890	COG1609	Transcriptional regulator
AK40_RS17900	COG2076	Multidrug Resistance protein
AK40_RS17905	COG2076	Multidrug Resistance protein
AK40_RS17945	COG1131	(ABC) transporter
AK40_RS17950	COG1725	Transcriptional regulator
AK40_RS17980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK40_RS18040	COG4970	Tfp pilus assembly protein FimT
AK40_RS18050	COG1459	type II secretion system
AK40_RS18055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AK40_RS18105	COG0646	methionine synthase
AK40_RS18105	COG1410	methionine synthase
AK40_RS18110	COG0646	methionine synthase
AK40_RS18110	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AK40_RS18120	COG0626	cystathionine gamma-synthase activity
AK40_RS18125	COG0626	cystathionine gamma-synthase activity
AK40_RS18145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_RS18155	COG1940	carbohydrate kinase activity
AK40_RS18160	COG4483	Protein conserved in bacteria
AK40_RS18165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AK40_RS18170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AK40_RS18175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AK40_RS18180	COG0704	Plays a role in the regulation of phosphate uptake
AK40_RS18190	COG0581	inorganic phosphate transmembrane transporter activity
AK40_RS18195	COG0573	inorganic phosphate transmembrane transporter activity
AK40_RS18200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AK40_RS18205	COG0768	penicillin binding
AK40_RS18210	COG0477	Major facilitator Superfamily
AK40_RS18215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK40_RS18240	COG0735	belongs to the Fur family
AK40_RS18245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AK40_RS18250	COG1121	(ABC) transporter
AK40_RS18255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_RS18285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AK40_RS18290	COG2384	SAM-dependent methyltransferase
AK40_RS18295	COG2010	Cytochrome c
AK40_RS18300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AK40_RS18305	COG0358	DNA primase activity
AK40_RS18325	COG0517	IMP dehydrogenase activity
AK40_RS18340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AK40_RS18345	COG0295	cytidine deaminase activity
AK40_RS18350	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AK40_RS18360	COG1480	7TM receptor with intracellular HD hydrolase
AK40_RS18365	COG1702	phosphate starvation-inducible protein PhoH
AK40_RS18385	COG1610	YqeY-like protein
AK40_RS18390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AK40_RS18395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AK40_RS18400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AK40_RS18430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AK40_RS18435	COG1733	regulation of RNA biosynthetic process
AK40_RS18460	COG1466	dna polymerase III delta subunit
AK40_RS18470	COG0658	competence protein
AK40_RS18470	COG2333	competence protein COMEC
AK40_RS18475	COG2131	deaminase
AK40_RS18480	COG1596	polysaccharide export
AK40_RS18480	COG1555	photosystem II stabilization
AK40_RS18485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK40_RS18490	COG2226	methyltransferase
AK40_RS18495	COG0799	negative regulation of ribosome biogenesis
AK40_RS18500	COG1713	HD superfamily hydrolase involved in NAD metabolism
AK40_RS18510	COG1534	Rna-binding protein
AK40_RS18520	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AK40_RS18525	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AK40_RS18550	COG1595	DNA-templated transcription, initiation
AK40_RS18560	COG0778	Nitroreductase
AK40_RS18565	COG2357	RelA SpoT domain protein
AK40_RS18575	COG1785	Belongs to the alkaline phosphatase family
AK40_RS18585	COG2267	carboxylic ester hydrolase activity
AK40_RS18620	COG1404	Belongs to the peptidase S8 family
AK40_RS18625	COG3186	Phenylalanine-4-hydroxylase
AK40_RS18635	COG2514	catechol 2,3-dioxygenase activity
AK40_RS18640	COG2259	Doxx family
AK40_RS18680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_RS18690	COG1454	alcohol dehydrogenase
AK40_RS18690	COG1012	belongs to the aldehyde dehydrogenase family
AK40_RS18695	COG0626	cystathionine gamma-synthase activity
AK40_RS18700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK40_RS18725	COG0768	penicillin binding
AK40_RS18740	COG0826	peptidase U32
AK40_RS18745	COG0826	peptidase U32
AK40_RS18750	COG4122	O-methyltransferase activity
AK40_RS18755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AK40_RS18785	COG0628	permease
AK40_RS18805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AK40_RS18820	COG1104	cysteine desulfurase activity
AK40_RS18825	COG1959	2 iron, 2 sulfur cluster binding
AK40_RS18830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AK40_RS18845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AK40_RS18870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AK40_RS18880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AK40_RS18880	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AK40_RS18885	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AK40_RS18890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AK40_RS18890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AK40_RS18900	COG2244	polysaccharide biosynthetic process
AK40_RS18905	COG2323	membrane
AK40_RS18915	COG1862	Preprotein translocase
AK40_RS18945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AK40_RS18955	COG0697	spore germination
AK40_RS18960	COG0640	Transcriptional regulator
AK40_RS18985	COG0157	Belongs to the NadC ModD family
AK40_RS18990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AK40_RS18995	COG1104	cysteine desulfurase activity
AK40_RS19000	COG1827	regulation of RNA biosynthetic process
AK40_RS19005	COG2258	MOSC domain
AK40_RS19010	COG0077	Prephenate dehydratase
AK40_RS19015	COG0577	efflux transmembrane transporter activity
AK40_RS19020	COG0577	efflux transmembrane transporter activity
AK40_RS19025	COG1136	(ABC) transporter
AK40_RS19030	COG5002	protein histidine kinase activity
AK40_RS19035	COG0745	RESPONSE REGULATOR receiver
AK40_RS19045	COG3290	protein histidine kinase activity
AK40_RS19055	COG2868	ribosomal protein
AK40_RS19065	COG1530	ribonuclease E activity
AK40_RS19070	COG1994	Peptidase M50
AK40_RS19075	COG0739	heme binding
AK40_RS19080	COG2894	cell division
AK40_RS19100	COG1077	Cell shape determining protein MreB Mrl
AK40_RS19155	COG2003	Belongs to the UPF0758 family
AK40_RS19170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK40_RS19205	COG4974	Belongs to the 'phage' integrase family
AK40_RS19225	COG0285	dihydrofolate synthase activity
AK40_RS19240	COG1388	LysM domain
AK40_RS19250	COG0113	porphobilinogen synthase activity
AK40_RS19255	COG1587	Uroporphyrinogen-III synthase
AK40_RS19265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AK40_RS19275	COG1846	Transcriptional regulator
AK40_RS19280	COG1764	response to oxidative stress
AK40_RS19295	COG1067	ATP-dependent peptidase activity
AK40_RS19295	COG0470	DNA polymerase III
AK40_RS19340	COG0622	Phosphoesterase
AK40_RS19355	COG5401	PFAM Sporulation and spore germination
AK40_RS19375	COG1309	transcriptional regulator
AK40_RS19390	COG2197	response regulator
AK40_RS19395	COG2233	PERMEase
AK40_RS19400	COG0402	S-adenosylhomocysteine deaminase activity
AK40_RS19410	COG1396	sequence-specific DNA binding
AK40_RS19415	COG0697	spore germination
AK40_RS19425	COG1959	2 iron, 2 sulfur cluster binding
AK40_RS19430	COG1668	transmembrane transport
AK40_RS19435	COG4152	abc transporter atp-binding protein
AK40_RS19440	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AK40_RS19445	COG1360	Flagellar Motor Protein
AK40_RS19450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AK40_RS19455	COG1876	peptidase activity
AK40_RS19460	COG0824	Thioesterase
AK40_RS19465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AK40_RS19470	COG1053	succinate dehydrogenase
AK40_RS19475	COG2009	succinate dehydrogenase
AK40_RS19480	COG1719	4-vinyl reductase, 4VR
AK40_RS19490	COG3118	belongs to the thioredoxin family
AK40_RS19495	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AK40_RS19500	COG2086	electron transfer activity
AK40_RS19505	COG1024	Enoyl-CoA hydratase
AK40_RS19510	COG1309	transcriptional regulator
AK40_RS19515	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_RS19535	COG2318	DinB family
AK40_RS19560	COG1131	(ABC) transporter
AK40_RS19565	COG2205	protein histidine kinase activity
AK40_RS19570	COG0745	RESPONSE REGULATOR receiver
AK40_RS19580	COG4895	conserved protein (DUF2196)
AK40_RS19585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AK40_RS19600	COG4509	Sortase family
AK40_RS19605	COG1120	ATPase activity
AK40_RS19620	COG5386	Cell surface protein
AK40_RS19625	COG5386	Cell surface protein
AK40_RS19630	COG1114	Component of the transport system for branched-chain amino acids
AK40_RS19635	COG1187	pseudouridine synthase activity
AK40_RS19650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AK40_RS19650	COG1796	DNA polymerase
AK40_RS19655	COG1286	toxin biosynthetic process
AK40_RS19700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AK40_RS19710	COG1418	mRNA catabolic process
AK40_RS19745	COG2814	Major facilitator Superfamily
AK40_RS19750	COG1566	PFAM secretion protein HlyD family protein
AK40_RS19755	COG1309	transcriptional regulator
AK40_RS19760	COG1363	Peptidase, m42
AK40_RS19785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AK40_RS19795	COG1484	DNA-dependent DNA replication
AK40_RS19800	COG3611	Membrane attachment protein
AK40_RS19810	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AK40_RS19815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AK40_RS19820	COG0237	dephospho-CoA kinase activity
AK40_RS19825	COG1971	Probably functions as a manganese efflux pump
AK40_RS19835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK40_RS19835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AK40_RS19840	COG5002	protein histidine kinase activity
AK40_RS19845	COG0745	RESPONSE REGULATOR receiver
AK40_RS19865	COG0538	isocitrate dehydrogenase activity
AK40_RS19870	COG0372	Belongs to the citrate synthase family
AK40_RS19885	COG0628	permease
AK40_RS19890	COG3030	protein affecting phage T7 exclusion by the F plasmid
AK40_RS19915	COG1725	Transcriptional regulator
AK40_RS19920	COG0281	malic enzyme
AK40_RS19925	COG0587	DNA-directed DNA polymerase activity
AK40_RS19940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AK40_RS19960	COG4109	DRTGG domain
AK40_RS19975	COG0006	proline dipeptidase activity
AK40_RS20020	COG0662	Cupin 2, conserved barrel domain protein
AK40_RS20030	COG1476	TRANSCRIPTIONal
AK40_RS20045	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS20050	COG0589	response to stress
AK40_RS20060	COG4974	Belongs to the 'phage' integrase family
AK40_RS20110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_RS20130	COG0827	DNA restriction-modification system
AK40_RS20135	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AK40_RS20140	COG3874	Sporulation protein YtfJ
AK40_RS20155	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AK40_RS20165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AK40_RS20180	COG1104	cysteine desulfurase activity
AK40_RS20190	COG0583	DNA-binding transcription factor activity
AK40_RS20195	COG0697	spore germination
AK40_RS20200	COG1309	transcriptional regulator
AK40_RS20205	COG1956	GAF domain-containing protein
AK40_RS20210	COG0626	cystathionine gamma-synthase activity
AK40_RS20260	COG1595	DNA-templated transcription, initiation
AK40_RS20270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AK40_RS20275	COG0454	-acetyltransferase
AK40_RS20280	COG0517	IMP dehydrogenase activity
AK40_RS20285	COG0123	including yeast histone deacetylase and acetoin utilization protein
AK40_RS20300	COG0745	RESPONSE REGULATOR receiver
AK40_RS20310	COG0666	response to abiotic stimulus
AK40_RS20345	COG1609	Transcriptional regulator
AK40_RS20355	COG4851	CamS sex pheromone cAM373 precursor
AK40_RS20360	COG3118	belongs to the thioredoxin family
AK40_RS20370	COG2309	aminopeptidase activity
AK40_RS20390	COG0577	efflux transmembrane transporter activity
AK40_RS20395	COG1136	(ABC) transporter
AK40_RS20405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_RS20410	COG1695	Transcriptional regulator
AK40_RS20430	COG1674	ftsk spoiiie
AK40_RS20440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK40_RS20450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK40_RS20455	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AK40_RS20460	COG1363	Peptidase, m42
AK40_RS20470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_RS20485	COG0510	thiamine kinase activity
AK40_RS20490	COG1523	belongs to the glycosyl hydrolase 13 family
AK40_RS20505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK40_RS20510	COG1349	DNA-binding transcription factor activity
AK40_RS20515	COG1187	pseudouridine synthase activity
AK40_RS20520	COG2244	polysaccharide biosynthetic process
AK40_RS20525	COG2081	HI0933 family
AK40_RS20530	COG2814	Major facilitator Superfamily
AK40_RS20540	COG3832	glyoxalase III activity
AK40_RS20560	COG1329	Transcriptional regulator
AK40_RS20585	COG0314	molybdopterin synthase activity
AK40_RS20590	COG1763	Mo-molybdopterin cofactor biosynthetic process
AK40_RS20595	COG0303	'Molybdopterin
AK40_RS20605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK40_RS20610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AK40_RS20630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_RS20640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AK40_RS20685	COG2814	Major facilitator Superfamily
AK40_RS20690	COG0475	glutathione-regulated potassium exporter activity
AK40_RS20695	COG0490	domain, Protein
AK40_RS20700	COG0582	viral genome integration into host DNA
AK40_RS20710	COG1136	(ABC) transporter
AK40_RS20730	COG1242	4 iron, 4 sulfur cluster binding
AK40_RS20735	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AK40_RS20750	COG1794	racemase activity, acting on amino acids and derivatives
AK40_RS20760	COG5504	Zn-dependent protease
AK40_RS20785	COG2267	carboxylic ester hydrolase activity
AK40_RS20790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AK40_RS20795	COG0671	phosphoesterase, PA-phosphatase related
AK40_RS20800	COG0438	transferase activity, transferring glycosyl groups
AK40_RS20810	COG0521	Mo-molybdopterin cofactor biosynthetic process
AK40_RS20865	COG0546	phosphoglycolate phosphatase activity
AK40_RS20870	COG1349	DNA-binding transcription factor activity
AK40_RS20880	COG5002	protein histidine kinase activity
AK40_RS20885	COG4191	Histidine kinase
AK40_RS20890	COG2267	carboxylic ester hydrolase activity
AK40_RS20895	COG1368	sulfuric ester hydrolase activity
AK40_RS20910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK40_RS20915	COG1116	anion transmembrane transporter activity
AK40_RS20920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK40_RS20935	COG0546	phosphoglycolate phosphatase activity
AK40_RS20945	COG0494	nUDIX hydrolase
AK40_RS20975	COG0288	reversible hydration of carbon dioxide
AK40_RS20980	COG1271	oxidase subunit
AK40_RS20985	COG1294	oxidase, subunit
AK40_RS21005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_RS21030	COG1842	Phage shock protein A
AK40_RS21100	COG3859	Proton-coupled thiamine transporter YuaJ
AK40_RS21105	COG5002	protein histidine kinase activity
AK40_RS21110	COG0745	RESPONSE REGULATOR receiver
AK40_RS21135	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AK40_RS21140	COG1597	lipid kinase activity
AK40_RS21170	COG0586	Pfam SNARE associated Golgi protein
AK40_RS21180	COG0577	efflux transmembrane transporter activity
AK40_RS21185	COG1136	(ABC) transporter
AK40_RS21190	COG3708	Transcriptional regulator
AK40_RS21190	COG2207	Transcriptional regulator
AK40_RS21195	COG0745	RESPONSE REGULATOR receiver
AK40_RS21200	COG2205	protein histidine kinase activity
AK40_RS21205	COG0577	efflux transmembrane transporter activity
AK40_RS21210	COG0577	efflux transmembrane transporter activity
AK40_RS21215	COG1136	(ABC) transporter
AK40_RS21220	COG0577	efflux transmembrane transporter activity
AK40_RS21235	COG2188	Transcriptional regulator
AK40_RS21255	COG3964	amidohydrolase
AK40_RS21275	COG4948	Mandelate Racemase Muconate Lactonizing
AK40_RS21285	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AK40_RS21290	COG0596	Alpha beta hydrolase
AK40_RS21300	COG1169	isochorismate synthase
AK40_RS21305	COG1575	Belongs to the MenA family. Type 1 subfamily
AK40_RS21310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AK40_RS21335	COG0058	SHG alpha-glucan phosphorylase activity
AK40_RS21345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AK40_RS21365	COG1404	Belongs to the peptidase S8 family
AK40_RS21465	COG0544	peptidyl-prolyl cis-trans isomerase activity
AK40_RS21560	COG1285	pathogenesis
AK40_RS21565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AK40_RS21585	COG2155	Conserved Protein
AK40_RS21590	COG1098	S1 RNA binding domain
AK40_RS21595	COG0436	Aminotransferase
AK40_RS21600	COG1522	sequence-specific DNA binding
AK40_RS21605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AK40_RS21610	COG2267	carboxylic ester hydrolase activity
AK40_RS21620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AK40_RS21640	COG5018	Exonuclease
AK40_RS21645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK40_RS21665	COG2050	protein possibly involved in aromatic compounds catabolism
AK40_RS21675	COG1268	BioY protein
AK40_RS21680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AK40_RS21685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AK40_RS21700	COG3584	3D domain protein
AK40_RS21715	COG1252	NADH dehydrogenase
AK40_RS21730	COG3708	Transcriptional regulator
AK40_RS21745	COG1683	Conserved Protein
AK40_RS21755	COG0316	Belongs to the HesB IscA family
AK40_RS21770	COG1252	NADH dehydrogenase
AK40_RS21780	COG2274	protein secretion by the type I secretion system
AK40_RS21785	COG0390	transport system, permease component
AK40_RS21790	COG2824	Alkylphosphonate utilization operon protein PhnA
AK40_RS21810	COG4837	Protein of unknown function (DUF1462)
AK40_RS21815	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AK40_RS21825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK40_RS21830	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AK40_RS21845	COG1136	(ABC) transporter
AK40_RS21845	COG0577	efflux transmembrane transporter activity
AK40_RS21850	COG2249	NAD(P)H dehydrogenase (quinone) activity
AK40_RS21860	COG0647	UMP catabolic process
AK40_RS21870	COG2445	Protein of unknown function DUF86
AK40_RS21875	COG1494	fructose-1,6-bisphosphatase
AK40_RS21895	COG4470	Protein conserved in bacteria
AK40_RS21905	COG0789	Transcriptional regulator
AK40_RS21910	COG4377	Putative membrane peptidase family (DUF2324)
AK40_RS21935	COG0739	heme binding
AK40_RS21945	COG3377	Domain of unknown function (DUF1805)
AK40_RS21950	COG0737	Belongs to the 5'-nucleotidase family
AK40_RS21960	COG1695	Transcriptional regulator
AK40_RS21970	COG0719	Fe-S assembly protein
AK40_RS21975	COG0822	iron-sulfur transferase activity
AK40_RS21980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AK40_RS21985	COG0719	Fe-S assembly protein
AK40_RS21990	COG0396	ATPase activity
AK40_RS21995	COG1464	Belongs to the NlpA lipoprotein family
AK40_RS22000	COG1464	Belongs to the NlpA lipoprotein family
AK40_RS22005	COG2011	ABC-type metal ion transport system permease component
AK40_RS22010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AK40_RS22020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK40_RS22025	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AK40_RS22035	COG1393	Belongs to the ArsC family
AK40_RS22085	COG0039	L-malate dehydrogenase activity
AK40_RS22110	COG1396	sequence-specific DNA binding
AK40_RS22115	COG1309	transcriptional regulator
AK40_RS22120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_RS22135	COG4555	ABC transporter
AK40_RS22160	COG1960	acyl-CoA dehydrogenase activity
AK40_RS22165	COG0183	Belongs to the thiolase family
AK40_RS22170	COG1024	Enoyl-CoA hydratase
AK40_RS22170	COG1250	3-hydroxyacyl-CoA dehydrogenase
AK40_RS22180	COG1686	Belongs to the peptidase S11 family
AK40_RS22195	COG0011	TIGRFAM Protein of
AK40_RS22200	COG0840	transmembrane signaling receptor activity
AK40_RS22220	COG2814	Major facilitator Superfamily
AK40_RS22225	COG0531	amino acid
AK40_RS22240	COG0706	membrane insertase activity
AK40_RS22250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_RS22285	COG0586	Pfam SNARE associated Golgi protein
AK40_RS22295	COG1376	ErfK ybiS ycfS ynhG family protein
AK40_RS22300	COG0745	RESPONSE REGULATOR receiver
AK40_RS22305	COG5002	protein histidine kinase activity
AK40_RS22330	COG0840	transmembrane signaling receptor activity
AK40_RS22335	COG2151	metal-sulfur cluster biosynthetic enzyme
AK40_RS22340	COG3227	Zinc metalloprotease (Elastase)
AK40_RS22345	COG1741	Belongs to the pirin family
AK40_RS22360	COG0475	glutathione-regulated potassium exporter activity
AK40_RS22365	COG0490	domain, Protein
AK40_RS22375	COG1115	amino acid carrier protein
AK40_RS22380	COG0783	Belongs to the Dps family
AK40_RS22395	COG1611	Belongs to the LOG family
AK40_RS22415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_RS22420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_RS22425	COG1115	amino acid carrier protein
AK40_RS22430	COG1115	amino acid carrier protein
AK40_RS22435	COG2910	NAD(P)H-binding
AK40_RS22450	COG0656	L-ascorbic acid biosynthetic process
AK40_RS22455	COG2814	Major facilitator Superfamily
AK40_RS22460	COG1733	regulation of RNA biosynthetic process
AK40_RS22470	COG1252	NADH dehydrogenase
AK40_RS22475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AK40_RS22490	COG0840	transmembrane signaling receptor activity
AK40_RS22490	COG3290	protein histidine kinase activity
AK40_RS22500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AK40_RS22525	COG0488	(ABC) transporter
AK40_RS22530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AK40_RS22540	COG2814	Major facilitator Superfamily
AK40_RS22590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AK40_RS22660	COG3104	oligopeptide transport
AK40_RS22675	COG0557	exoribonuclease II activity
AK40_RS22680	COG1647	Serine aminopeptidase, S33
AK40_RS22685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AK40_RS22690	COG1346	cytolysis
AK40_RS22725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AK40_RS22740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AK40_RS22765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_RS22780	COG2323	membrane
AK40_RS22790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK40_RS22800	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AK40_RS22810	COG1051	belongs to the nudix hydrolase family
AK40_RS22820	COG0492	ferredoxin-NADP+ reductase activity
AK40_RS22825	COG0457	Tetratricopeptide repeat
AK40_RS22830	COG0110	maltose O-acetyltransferase activity
AK40_RS22850	COG1950	PFAM Membrane protein of
AK40_RS22860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AK40_RS22865	COG0556	nucleotide-excision repair
AK40_RS22880	COG0789	Transcriptional regulator
AK40_RS22905	COG2855	membrane
AK40_RS22910	COG0583	DNA-binding transcription factor activity
AK40_RS22920	COG0655	NAD(P)H dehydrogenase (quinone) activity
AK40_RS22925	COG0488	(ABC) transporter
AK40_RS22935	COG1132	(ABC) transporter
AK40_RS22940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK40_RS22945	COG3409	Peptidoglycan-binding domain 1 protein
AK40_RS22945	COG0793	Belongs to the peptidase S41A family
AK40_RS22950	COG2177	Part of the ABC transporter FtsEX involved in
AK40_RS22955	COG2884	Cell division ATP-binding protein ftsE
AK40_RS22970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AK40_RS22980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AK40_RS22985	COG1278	Cold shock
AK40_RS22990	COG1040	competence protein
AK40_RS22995	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AK40_RS23000	COG0791	NLP P60 protein
AK40_RS23000	COG1388	LysM domain
AK40_RS23005	COG1733	regulation of RNA biosynthetic process
AK40_RS23015	COG1307	EDD domain protein, DegV family
AK40_RS23020	COG1739	Uncharacterized protein family UPF0029
AK40_RS23025	COG1316	TRANSCRIPTIONal
AK40_RS23030	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AK40_RS23035	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AK40_RS23040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AK40_RS23050	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AK40_RS23050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AK40_RS23070	COG1486	melibiose metabolic process
AK40_RS23075	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK40_RS23080	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK40_RS23090	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AK40_RS23110	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK40_RS23120	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK40_RS23125	COG1301	dicarboxylic acid transport
AK40_RS23135	COG0346	lactoylglutathione lyase activity
AK40_RS23155	COG1511	domain protein
AK40_RS23160	COG0583	DNA-binding transcription factor activity
AK40_RS23165	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AK40_RS23175	COG1271	oxidase subunit
AK40_RS23180	COG1294	oxidase, subunit
AK40_RS23185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AK40_RS23195	COG1620	l-lactate permease
AK40_RS23210	COG2389	metal-binding protein
AK40_RS23220	COG1368	sulfuric ester hydrolase activity
AK40_RS23230	COG0791	NLP P60 protein
AK40_RS23230	COG1388	LysM domain
AK40_RS23235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_RS23245	COG1215	transferase activity, transferring glycosyl groups
AK40_RS23255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK40_RS23260	COG3584	3D domain protein
AK40_RS23260	COG1388	LysM domain
AK40_RS23285	COG4715	Zinc finger, swim domain protein
AK40_RS23290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK40_RS23335	COG0577	efflux transmembrane transporter activity
AK40_RS23340	COG1136	(ABC) transporter
AK40_RS23380	COG0745	RESPONSE REGULATOR receiver
AK40_RS23385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AK40_RS23395	COG1316	TRANSCRIPTIONal
AK40_RS23400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AK40_RS23405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AK40_RS23410	COG1215	transferase activity, transferring glycosyl groups
AK40_RS23420	COG1216	Glycosyl transferase, family 2
AK40_RS23420	COG1442	glycosyl transferase family 8
AK40_RS23440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AK40_RS23445	COG4464	protein tyrosine phosphatase activity
AK40_RS23450	COG0489	protein tyrosine kinase activity
AK40_RS23455	COG3944	biosynthesis protein
AK40_RS23460	COG0489	protein tyrosine kinase activity
AK40_RS23475	COG1609	Transcriptional regulator
AK40_RS23485	COG0739	heme binding
AK40_RS23500	COG3279	Response regulator of the LytR AlgR family
AK40_RS23505	COG2385	sporulation resulting in formation of a cellular spore
AK40_RS23520	COG4836	Membrane
AK40_RS23525	COG1007	ATP synthesis coupled electron transport
AK40_RS23530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AK40_RS23535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AK40_RS23545	COG0839	Belongs to the complex I subunit 6 family
AK40_RS23565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AK40_RS23580	COG3300	MHYT domain
AK40_RS23580	COG5001	Diguanylate cyclase
AK40_RS23630	COG0356	it plays a direct role in the translocation of protons across the membrane
AK40_RS23665	COG0698	ribose 5-phosphate isomerase
AK40_RS23675	COG2190	(PTS) system
AK40_RS23680	COG2259	Doxx family
AK40_RS23685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AK40_RS23700	COG0009	L-threonylcarbamoyladenylate synthase
AK40_RS23715	COG2890	protein-(glutamine-N5) methyltransferase activity
AK40_RS23735	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AK40_RS23740	COG1494	fructose-1,6-bisphosphatase
AK40_RS23760	COG4821	SIS domain
AK40_RS23780	COG1960	acyl-CoA dehydrogenase activity
AK40_RS23785	COG1960	acyl-CoA dehydrogenase activity
AK40_RS23790	COG1250	3-hydroxyacyl-CoA dehydrogenase
AK40_RS23795	COG0183	Belongs to the thiolase family
AK40_RS23800	COG0247	lactate metabolic process
AK40_RS23800	COG2181	nitrate reductase activity
AK40_RS23805	COG3620	sequence-specific DNA binding
AK40_RS23845	COG1404	Belongs to the peptidase S8 family
AK40_RS23850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AK40_RS23895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK40_RS23905	COG5001	Diguanylate cyclase
AK40_RS23905	COG3300	MHYT domain
AK40_RS23925	COG2197	response regulator
AK40_RS23930	COG4585	Histidine kinase
AK40_RS23935	COG0842	Transport permease protein
AK40_RS23940	COG1131	(ABC) transporter
AK40_RS23945	COG0024	Methionine aminopeptidase
AK40_RS23955	COG2234	aminopeptidase activity
AK40_RS23975	COG1595	DNA-templated transcription, initiation
AK40_RS23985	COG4506	Protein conserved in bacteria
AK40_RS23990	COG1619	proteins homologs of microcin C7 resistance protein MccF
AK40_RS24010	COG0010	Belongs to the arginase family
AK40_RS24020	COG2814	Major facilitator Superfamily
AK40_RS24025	COG0789	Transcriptional regulator
AK40_RS24030	COG0584	glycerophosphoryl diester phosphodiesterase
AK40_RS24035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK40_RS24045	COG1994	Peptidase M50
AK40_RS24055	COG1078	dGTPase activity
AK40_RS24060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_RS24065	COG1120	ATPase activity
AK40_RS24070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_RS24075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_RS24095	COG0095	Lipoate-protein ligase
AK40_RS24100	COG0280	phosphate acetyltransferase
AK40_RS24115	COG3773	Cell wall hydrolase
AK40_RS24125	COG2363	Small membrane protein
AK40_RS24135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AK40_RS24140	COG2233	PERMEase
AK40_RS24145	COG0561	phosphatase activity
AK40_RS24150	COG2814	Major facilitator Superfamily
AK40_RS24160	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AK40_RS24165	COG1131	(ABC) transporter
AK40_RS24170	COG2755	lipolytic protein G-D-S-L family
AK40_RS24175	COG1609	Transcriptional regulator
AK40_RS24185	COG0460	homoserine dehydrogenase
AK40_RS24195	COG2873	o-acetylhomoserine
AK40_RS24200	COG1011	Hydrolase
AK40_RS24215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AK40_RS24225	COG2197	response regulator
AK40_RS24230	COG2203	Gaf domain
AK40_RS24230	COG4585	Histidine kinase
AK40_RS24235	COG0351	phosphomethylpyrimidine kinase
AK40_RS24240	COG3706	GGDEF domain
AK40_RS24245	COG2879	small protein
AK40_RS24250	COG1966	Carbon starvation protein
AK40_RS24255	COG3279	Response regulator of the LytR AlgR family
AK40_RS24260	COG0477	Major facilitator Superfamily
AK40_RS24285	COG0840	transmembrane signaling receptor activity
AK40_RS24295	COG1607	acyl-coa hydrolase
AK40_RS24310	COG0488	(ABC) transporter
AK40_RS24330	COG0463	Glycosyl transferase, family 2
AK40_RS24335	COG1309	transcriptional regulator
AK40_RS24340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AK40_RS24345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK40_RS24345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AK40_RS24350	COG0628	permease
AK40_RS24365	COG3279	Response regulator of the LytR AlgR family
AK40_RS24370	COG3275	phosphorelay sensor kinase activity
AK40_RS24375	COG2814	Major facilitator Superfamily
AK40_RS24380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK40_RS24385	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AK40_RS24390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AK40_RS24410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AK40_RS24415	COG1272	protein, Hemolysin III
AK40_RS24440	COG1164	Oligoendopeptidase f
AK40_RS24470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AK40_RS24475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AK40_RS24480	COG4853	Protein conserved in bacteria
AK40_RS24485	COG4863	YycH protein
AK40_RS24490	COG5002	protein histidine kinase activity
AK40_RS24495	COG0745	RESPONSE REGULATOR receiver
AK40_RS24525	COG0305	Participates in initiation and elongation during chromosome replication
AK40_RS24535	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AK40_RS24540	COG4241	membrane
AK40_RS24550	COG0629	single-stranded DNA binding
AK40_RS24560	COG0012	GTP binding
AK40_RS24565	COG4481	Protein conserved in bacteria
AK40_RS24570	COG0668	transmembrane transport
AK40_RS24580	COG1475	DNA binding
AK40_RS24585	COG1192	Involved in chromosome partitioning
AK40_RS24610	COG1847	R3H domain protein
AK40_RS24615	COG0706	membrane insertase activity
AK40_RS24625	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AK40_RS24635	COG0592	DNA-directed DNA polymerase activity
AK40_RS24640	COG2501	S4 domain
AK40_RS24650	COG0187	DNA topoisomerase II activity
AK40_RS24655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AK40_RS24690	COG0516	GMP reductase activity
AK40_RS24690	COG0517	IMP dehydrogenase activity
AK40_RS24695	COG1686	Belongs to the peptidase S11 family
AK40_RS24725	COG1428	Deoxynucleoside kinase
AK40_RS24730	COG1428	Deoxynucleoside kinase
AK40_RS24735	COG1335	isochorismatase
AK40_RS24745	COG0590	tRNA wobble adenosine to inosine editing
AK40_RS24750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AK40_RS24805	COG1982	Orn Lys Arg decarboxylase major
AK40_RS24815	COG0470	DNA polymerase III
AK40_RS24820	COG1774	PSP1 C-terminal conserved region
AK40_RS24830	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AK40_RS24840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AK40_RS24845	COG2002	toxin-antitoxin pair type II binding
AK40_RS24850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK40_RS24850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AK40_RS24855	COG0084	hydrolase, TatD family'
AK40_RS24860	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AK40_RS24875	COG4466	Protein conserved in bacteria
AK40_RS24890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AK40_RS24895	COG0251	oxidation-reduction process
AK40_RS24925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AK40_RS24930	COG2002	toxin-antitoxin pair type II binding
AK40_RS24935	COG2244	polysaccharide biosynthetic process
AK40_RS24940	COG3956	TIGRFAM MazG family protein
AK40_RS24945	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AK40_RS24965	COG1098	S1 RNA binding domain
AK40_RS24980	COG2208	phosphoserine phosphatase activity
AK40_RS24990	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AK40_RS24995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AK40_RS25010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AK40_RS25015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AK40_RS25020	COG0512	Glutamine amidotransferase of anthranilate synthase
AK40_RS25025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AK40_RS25030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AK40_RS25035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AK40_RS25040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AK40_RS25045	COG1396	sequence-specific DNA binding
AK40_RS25050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AK40_RS25080	COG3880	PFAM UvrB UvrC protein
AK40_RS25090	COG0542	response to heat
AK40_RS25095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AK40_RS25105	COG4956	integral membrane protein (PIN domain superfamily)
AK40_RS25125	COG1045	serine acetyltransferase
AK40_RS25140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AK40_RS25145	COG3688	RNA-binding protein containing a PIN domain
AK40_RS25160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AK40_RS25165	COG0250	Participates in transcription elongation, termination and antitermination
AK40_RS25170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AK40_RS25190	COG2813	Specifically methylates the guanine in position
AK40_RS25205	COG1358	cellular component organization or biogenesis
AK40_RS25275	COG0255	Belongs to the universal ribosomal protein uL29 family
AK40_RS25335	COG0201	protein transport
AK40_RS25345	COG0024	Methionine aminopeptidase
AK40_RS25355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AK40_RS25390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AK40_RS25415	COG0860	N-Acetylmuramoyl-L-alanine amidase
AK40_RS25420	COG0489	protein tyrosine kinase activity
AK40_RS25430	COG2194	sulfuric ester hydrolase activity
AK40_RS25435	COG0726	polysaccharide deacetylase
AK40_RS25515	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AK40_RS25520	COG4856	YbbR-like protein
AK40_RS25565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AK40_RS25600	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS25605	COG2011	ABC-type metal ion transport system permease component
AK40_RS25610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AK40_RS25615	COG1464	Belongs to the NlpA lipoprotein family
AK40_RS25620	COG0604	alcohol dehydrogenase
AK40_RS25630	COG0277	FAD linked oxidase domain protein
AK40_RS25635	COG2271	Major facilitator Superfamily
AK40_RS25645	COG2814	Major facilitator Superfamily
AK40_RS25660	COG0601	transmembrane transport
AK40_RS25665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK40_RS25670	COG0444	Belongs to the ABC transporter superfamily
AK40_RS25675	COG4608	Belongs to the ABC transporter superfamily
AK40_RS25680	COG4166	transmembrane transport
AK40_RS25690	COG2207	Transcriptional regulator
AK40_RS25700	COG1309	transcriptional regulator
AK40_RS25710	COG4166	transmembrane transport
AK40_RS25715	COG4166	transmembrane transport
AK40_RS25720	COG0656	L-ascorbic acid biosynthetic process
AK40_RS25725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AK40_RS25740	COG4149	molybdate abc transporter
AK40_RS25745	COG0725	ABC transporter, periplasmic molybdate-binding protein
AK40_RS25750	COG1910	domain protein
AK40_RS25770	COG0697	spore germination
AK40_RS25780	COG0204	Acyl-transferase
AK40_RS25790	COG1609	Transcriptional regulator
AK40_RS25800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_RS25825	COG5298	Protein conserved in bacteria
AK40_RS25850	COG0488	(ABC) transporter
AK40_RS25865	COG0747	negative chemotaxis
AK40_RS25870	COG0601	transmembrane transport
AK40_RS25875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK40_RS25880	COG0444	Belongs to the ABC transporter superfamily
AK40_RS25885	COG4608	Belongs to the ABC transporter superfamily
AK40_RS25890	COG0561	phosphatase activity
AK40_RS25925	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AK40_RS25930	COG0179	Fumarylacetoacetate (FAA) hydrolase
AK40_RS25940	COG0531	amino acid
AK40_RS25955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AK40_RS25965	COG4294	response to UV
AK40_RS25970	COG0705	Rhomboid family
AK40_RS25970	COG0457	Tetratricopeptide repeat
AK40_RS25980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AK40_RS25985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AK40_RS25990	COG0864	Transcriptional regulator
AK40_RS25995	COG2337	Toxic component of a toxin-antitoxin (TA) module
AK40_RS26000	COG2183	response to ionizing radiation
AK40_RS26095	COG0802	atpase or kinase
AK40_RS26100	COG1214	PFAM Peptidase M22, glycoprotease
AK40_RS26105	COG0456	acetyltransferase
AK40_RS26115	COG0488	(ABC) transporter
AK40_RS26130	COG1266	CAAX protease self-immunity
AK40_RS26150	COG5444	nuclease activity
AK40_RS26165	COG2252	PERMEase
AK40_RS26175	COG5002	protein histidine kinase activity
AK40_RS26200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AK40_RS26265	COG2205	protein histidine kinase activity
AK40_RS26270	COG0745	RESPONSE REGULATOR receiver
AK40_RS26290	COG0697	spore germination
AK40_RS26315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AK40_RS26320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AK40_RS26325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AK40_RS26335	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AK40_RS26350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AK40_RS26360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AK40_RS26370	COG0151	Belongs to the GarS family
AK40_RS26400	COG0210	DNA helicase
AK40_RS26410	COG4851	CamS sex pheromone cAM373 precursor
AK40_RS26430	COG1335	isochorismatase
AK40_RS26440	COG2011	ABC-type metal ion transport system permease component
AK40_RS26445	COG1464	Belongs to the NlpA lipoprotein family
AK40_RS26460	COG0003	Pfam Anion-transporting ATPase
AK40_RS26465	COG1846	Transcriptional regulator
AK40_RS26470	COG4682	membrane
AK40_RS26490	COG1597	lipid kinase activity
AK40_RS26495	COG0546	phosphoglycolate phosphatase activity
AK40_RS26500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AK40_RS26510	COG1012	belongs to the aldehyde dehydrogenase family
AK40_RS26515	COG2076	Multidrug Resistance protein
AK40_RS26520	COG2309	aminopeptidase activity
AK40_RS26535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_RS26540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AK40_RS26545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AK40_RS26550	COG5002	protein histidine kinase activity
AK40_RS26555	COG4807	Protein conserved in bacteria
AK40_RS26580	COG1757	Na H antiporter
AK40_RS26585	COG1473	amidohydrolase
AK40_RS26605	COG0450	alkyl hydroperoxide reductase
AK40_RS26625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_RS26630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_RS26635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_RS26655	COG0166	Belongs to the GPI family
AK40_RS26685	COG5002	protein histidine kinase activity
AK40_RS26705	COG3541	Predicted nucleotidyltransferase
AK40_RS26710	COG2814	Major facilitator Superfamily
AK40_RS26715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK40_RS26715	COG0723	plastoquinol--plastocyanin reductase activity
AK40_RS26725	COG0765	amino acid transport
AK40_RS26730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK40_RS26740	COG0840	transmembrane signaling receptor activity
AK40_RS26745	COG0840	transmembrane signaling receptor activity
AK40_RS26750	COG0366	Alpha amylase catalytic
AK40_RS26755	COG2190	(PTS) system
AK40_RS26755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_RS26755	COG1263	PTS System
AK40_RS26785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AK40_RS26800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK40_RS26810	COG1116	anion transmembrane transporter activity
AK40_RS26815	COG0488	(ABC) transporter
AK40_RS26865	COG2270	Major facilitator Superfamily
AK40_RS26895	COG2310	stress, protein
AK40_RS26900	COG2310	stress, protein
AK40_RS26905	COG2310	stress, protein
AK40_RS26910	COG0861	Integral membrane protein TerC family
AK40_RS26920	COG3853	Toxic anion resistance protein (TelA)
AK40_RS26935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AK40_RS26945	COG1295	ribonuclease BN
AK40_RS26950	COG2217	Heavy metal translocating P-type atpase
AK40_RS26955	COG0697	spore germination
AK40_RS26965	COG0681	Belongs to the peptidase S26 family
AK40_RS26975	COG0586	Pfam SNARE associated Golgi protein
AK40_RS26990	COG3871	stress protein (general stress protein 26)
AK40_RS26995	COG0387	Pfam Sodium calcium exchanger
AK40_RS27005	COG0535	radical SAM domain protein
AK40_RS27025	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AK40_RS27045	COG3829	transcription factor binding
AK40_RS27055	COG0833	amino acid
AK40_RS27060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AK40_RS27095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_RS27095	COG1263	PTS System
AK40_RS27100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AK40_RS27115	COG0463	Glycosyl transferase, family 2
AK40_RS27125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AK40_RS27125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK40_RS27145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AK40_RS27165	COG1228	amidohydrolase
AK40_RS27170	COG1090	epimerase
AK40_RS27200	COG1988	membrane-bound metal-dependent
AK40_RS27205	COG1194	a g-specific adenine glycosylase
AK40_RS27230	COG1132	(ABC) transporter
AK40_RS27235	COG4129	membrane
AK40_RS27240	COG0070	glutamate synthase
AK40_RS27240	COG0067	glutamate synthase
AK40_RS27240	COG0069	glutamate synthase activity
AK40_RS27250	COG4555	ABC transporter
AK40_RS27270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AK40_RS27275	COG0735	belongs to the Fur family
AK40_RS27400	COG1132	(ABC) transporter
AK40_RS27415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AK40_RS27420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AK40_RS27435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AK40_RS27445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AK40_RS27450	COG1716	ATPase activity
AK40_RS27450	COG5001	Diguanylate cyclase
AK40_RS27460	COG2766	serine protein kinase
AK40_RS27485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AK40_RS27495	COG1585	Membrane protein implicated in regulation of membrane protease activity
AK40_RS27500	COG2268	Band 7 protein
AK40_RS27510	COG3290	protein histidine kinase activity
AK40_RS27515	COG4565	transcriptional regulatory protein
AK40_RS27520	COG2851	Citrate transporter
AK40_RS27540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AK40_RS27545	COG0745	RESPONSE REGULATOR receiver
AK40_RS27550	COG5002	protein histidine kinase activity
AK40_RS27560	COG4990	cell redox homeostasis
AK40_RS27570	COG3290	protein histidine kinase activity
AK40_RS27575	COG4565	transcriptional regulatory protein
AK40_RS27580	COG3493	citrate carrier protein
AK40_RS27585	COG0281	malic enzyme
AK40_RS27600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AK40_RS27610	COG5002	protein histidine kinase activity
AK40_RS27615	COG0745	RESPONSE REGULATOR receiver
AK40_RS27625	COG0454	-acetyltransferase
AK40_RS27625	COG0456	acetyltransferase
AK40_RS27630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AK40_RS27635	COG3383	formate dehydrogenase (NAD+) activity
AK40_RS27640	COG2427	Protein of unknown function (DUF1641)
AK40_RS27655	COG0531	amino acid
AK40_RS27660	COG0640	Transcriptional regulator
AK40_RS27665	COG2217	Heavy metal translocating P-type atpase
AK40_RS27670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AK40_RS27680	COG3227	Zinc metalloprotease (Elastase)
AK40_RS27700	COG2720	vancomycin resistance protein
AK40_RS27705	COG1316	TRANSCRIPTIONal
AK40_RS27710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AK40_RS27715	COG0346	lactoylglutathione lyase activity
AK40_RS27720	COG1253	flavin adenine dinucleotide binding
AK40_RS27725	COG1027	Aspartate ammonia-lyase
AK40_RS27730	COG1620	l-lactate permease
AK40_RS27745	COG3104	oligopeptide transport
AK40_RS27750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AK40_RS27755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_RS27760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AK40_RS27775	COG0156	8-amino-7-oxononanoate synthase activity
AK40_RS27780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AK40_RS27790	COG4548	von Willebrand factor, type A
AK40_RS27795	COG0714	Associated with various cellular activities
AK40_RS27800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK40_RS27815	COG0531	amino acid
AK40_RS27820	COG2188	Transcriptional regulator
AK40_RS27825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_RS27825	COG1263	PTS System
AK40_RS27830	COG0366	Alpha amylase catalytic
AK40_RS27845	COG0697	spore germination
AK40_RS27850	COG4585	Histidine kinase
AK40_RS27855	COG2197	response regulator
AK40_RS27860	COG1404	Belongs to the peptidase S8 family
AK40_RS27875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AK40_RS27880	COG1115	amino acid carrier protein
AK40_RS27885	COG1126	abc transporter atp-binding protein
AK40_RS27890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK40_RS27895	COG0765	amino acid transport
AK40_RS27900	COG0765	amino acid transport
AK40_RS27905	COG0833	amino acid
AK40_RS27920	COG1595	DNA-templated transcription, initiation
AK40_RS27930	COG2378	regulation of single-species biofilm formation
AK40_RS27935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AK40_RS27940	COG5002	protein histidine kinase activity
AK40_RS27955	COG0659	secondary active sulfate transmembrane transporter activity
AK40_RS27970	COG0747	negative chemotaxis
AK40_RS27980	COG0601	transmembrane transport
AK40_RS27985	COG4608	Belongs to the ABC transporter superfamily
AK40_RS27995	COG2271	Major facilitator Superfamily
AK40_RS28000	COG1846	Transcriptional regulator
AK40_RS28005	COG0477	Major facilitator Superfamily
AK40_RS28010	COG1609	Transcriptional regulator
AK40_RS28015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AK40_RS28030	COG1172	Belongs to the binding-protein-dependent transport system permease family
AK40_RS28035	COG1879	ABC-type sugar transport system periplasmic component
AK40_RS28055	COG1063	alcohol dehydrogenase
AK40_RS28070	COG3568	Endonuclease Exonuclease Phosphatase
AK40_RS28100	COG0840	transmembrane signaling receptor activity
AK40_RS28105	COG1388	LysM domain
AK40_RS28105	COG3584	3D domain protein
AK40_RS28110	COG1476	TRANSCRIPTIONal
AK40_RS28125	COG3104	oligopeptide transport
AK40_RS28130	COG1114	Component of the transport system for branched-chain amino acids
AK40_RS28145	COG1113	amino acid transport
AK40_RS28150	COG2252	PERMEase
AK40_RS28165	COG2153	protein acetylation
AK40_RS28175	COG0569	domain protein
AK40_RS28175	COG0475	glutathione-regulated potassium exporter activity
AK40_RS28190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AK40_RS28195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AK40_RS28205	COG4990	cell redox homeostasis
AK40_RS28220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK40_RS28225	COG0697	spore germination
AK40_RS28230	COG0531	amino acid
AK40_RS28245	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK40_RS28250	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK40_RS28255	COG1918	ferrous iron import across plasma membrane
AK40_RS28255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AK40_RS28260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AK40_RS28265	COG0573	inorganic phosphate transmembrane transporter activity
AK40_RS28270	COG0581	inorganic phosphate transmembrane transporter activity
AK40_RS28280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AK40_RS28400	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AK40_RS28425	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AK40_RS28430	COG1116	anion transmembrane transporter activity
AK40_RS28435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AK40_RS28440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AK40_RS28445	COG0352	thiamine-phosphate diphosphorylase activity
AK40_RS28450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK40_RS28455	COG2104	thiamine diphosphate biosynthetic process
AK40_RS28465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AK40_RS28470	COG0351	phosphomethylpyrimidine kinase
AK40_RS28510	COG2205	protein histidine kinase activity
AK40_RS28515	COG2814	Major facilitator Superfamily
AK40_RS28520	COG1846	Transcriptional regulator
AK40_RS28545	COG1136	(ABC) transporter
AK40_RS28545	COG0577	efflux transmembrane transporter activity
AK40_RS28555	COG2252	PERMEase
AK40_RS28560	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS28575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AK40_RS28580	COG1621	beta-fructofuranosidase activity
AK40_RS28585	COG1263	PTS System
AK40_RS28585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_RS28590	COG1609	Transcriptional regulator
AK40_RS28600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AK40_RS28640	COG0778	Nitroreductase
AK40_RS28645	COG2719	SpoVR family
AK40_RS28650	COG0446	pyridine nucleotide-disulphide oxidoreductase
AK40_RS28655	COG1937	Protein conserved in bacteria
AK40_RS28660	COG0425	Belongs to the sulfur carrier protein TusA family
AK40_RS28660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_RS28665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_RS28665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AK40_RS28670	COG0425	Belongs to the sulfur carrier protein TusA family
AK40_RS28675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AK40_RS28685	COG2210	Belongs to the sulfur carrier protein TusA family
AK40_RS28690	COG0730	response to heat
AK40_RS28700	COG1316	TRANSCRIPTIONal
AK40_RS28705	COG0604	alcohol dehydrogenase
AK40_RS28710	COG1283	sodium-dependent phosphate transmembrane transporter activity
AK40_RS28725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AK40_RS28725	COG3711	transcriptional antiterminator
AK40_RS28730	COG1447	Phosphotransferase system cellobiose-specific component IIA
AK40_RS28735	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AK40_RS28755	COG3584	3D domain protein
AK40_RS28755	COG1388	LysM domain
AK40_RS28760	COG0577	efflux transmembrane transporter activity
AK40_RS28765	COG1136	(ABC) transporter
AK40_RS28775	COG5522	Integral membrane protein (intg_mem_TP0381)
AK40_RS28790	COG0577	efflux transmembrane transporter activity
AK40_RS28795	COG1114	Component of the transport system for branched-chain amino acids
AK40_RS28800	COG3546	catalase activity
AK40_RS28835	COG0586	Pfam SNARE associated Golgi protein
AK40_RS28870	COG0531	amino acid
AK40_RS28875	COG0475	glutathione-regulated potassium exporter activity
AK40_RS28885	COG1737	Transcriptional regulator
AK40_RS28895	COG1263	PTS System
AK40_RS28895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AK40_RS28910	COG2259	Doxx family
AK40_RS28930	COG1522	sequence-specific DNA binding
AK40_RS28945	COG2076	Multidrug Resistance protein
AK40_RS28950	COG1309	transcriptional regulator
AK40_RS28955	COG2814	Major facilitator Superfamily
AK40_RS28965	COG4533	DNA binding
AK40_RS28970	COG2211	Major facilitator Superfamily
AK40_RS28980	COG0693	protein deglycase activity
AK40_RS28985	COG0753	catalase activity
AK40_RS28985	COG0693	protein deglycase activity
AK40_RS28995	COG0531	amino acid
AK40_RS29010	COG1012	belongs to the aldehyde dehydrogenase family
AK40_RS29020	COG1132	(ABC) transporter
AK40_RS29025	COG1132	(ABC) transporter
AK40_RS29030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK40_RS29035	COG0765	amino acid transport
AK40_RS29040	COG1126	abc transporter atp-binding protein
AK40_RS29055	COG0189	ligase activity
AK40_RS29085	COG0028	Belongs to the TPP enzyme family
AK40_RS29090	COG3527	Alpha-acetolactate decarboxylase
AK40_RS29100	COG0561	phosphatase activity
AK40_RS29110	COG5632	N-Acetylmuramoyl-L-alanine amidase
AK40_RS29110	COG3409	Peptidoglycan-binding domain 1 protein
AK40_RS29115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AK40_RS29130	COG0659	secondary active sulfate transmembrane transporter activity
AK40_RS29155	COG0653	protein targeting
AK40_RS29160	COG2244	polysaccharide biosynthetic process
AK40_RS29170	COG4196	transglutaminase domain protein
AK40_RS29175	COG4196	transglutaminase domain protein
AK40_RS29195	COG1024	Enoyl-CoA hydratase
AK40_RS29220	COG1363	Peptidase, m42
AK40_RS29240	COG2207	Transcriptional regulator
AK40_RS29240	COG3708	Transcriptional regulator
AK40_RS29255	COG4974	Belongs to the 'phage' integrase family
AK40_RS29270	COG3938	Belongs to the proline racemase family
AK40_RS29300	COG0601	transmembrane transport
AK40_RS29305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK40_RS29310	COG0444	Belongs to the ABC transporter superfamily
AK40_RS29315	COG4608	Belongs to the ABC transporter superfamily
AK40_RS29345	COG0556	nucleotide-excision repair
AK40_RS29365	COG0477	Major facilitator Superfamily
AK40_RS29370	COG3290	protein histidine kinase activity
AK40_RS29375	COG4565	transcriptional regulatory protein
AK40_RS29380	COG3181	Tripartite tricarboxylate transporter family receptor
AK40_RS29435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AK40_RS29485	COG4978	Transcriptional regulator
AK40_RS29485	COG0789	Transcriptional regulator
AK40_RS29500	COG0305	Participates in initiation and elongation during chromosome replication
AK40_RS29535	COG0477	Major facilitator Superfamily
AK40_RS29600	COG3320	Male sterility
AK40_RS29600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AK40_RS29605	COG1309	transcriptional regulator
AK40_RS29620	COG1183	phosphatidylcholine synthase activity
AK40_RS29650	COG2376	Dihydroxyacetone kinase
AK40_RS29665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AK40_RS29670	COG1959	2 iron, 2 sulfur cluster binding
AK40_RS29685	COG0457	Tetratricopeptide repeat
AK40_RS29690	COG3437	response regulator, receiver
AK40_RS29690	COG2770	Histidine kinase
AK40_RS29765	COG1191	sigma factor activity
AK40_RS29775	COG2208	phosphoserine phosphatase activity
AK40_RS29780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AK40_RS29785	COG0784	Response regulator, receiver
AK40_RS29785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AK40_RS29785	COG2198	Histidine kinase
AK40_RS29785	COG2205	protein histidine kinase activity
AK40_RS29850	COG0420	3'-5' exonuclease activity
AK40_RS29855	COG4717	serine-type aminopeptidase activity
AK40_RS29885	COG0346	lactoylglutathione lyase activity
AK40_RS29890	COG0346	lactoylglutathione lyase activity
AK40_RS29895	COG0457	Tetratricopeptide repeat
AK40_RS29905	COG2267	carboxylic ester hydrolase activity
AK40_RS29925	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AK40_RS29930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AK40_RS29940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AK40_RS29985	COG0477	Major facilitator Superfamily
AK40_RS29990	COG0477	Major facilitator Superfamily
AK40_RS30000	COG3973	AAA domain
AK40_RS30005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK40_RS30030	COG4980	gas vesicle protein
AK40_RS30035	COG0537	adenosine 5'-monophosphoramidase activity
AK40_RS30040	COG1131	(ABC) transporter
AK40_RS30045	COG4473	ABC transporter
AK40_RS30055	COG1309	transcriptional regulator
AK40_RS30065	COG3402	PFAM membrane-flanked domain
AK40_RS30070	COG3428	Bacterial PH domain
AK40_RS30090	COG1309	transcriptional regulator
AK40_RS30110	COG3402	PFAM membrane-flanked domain
AK40_RS30115	COG3428	Bacterial PH domain
AK40_RS30120	COG2329	Antibiotic biosynthesis monooxygenase
AK40_RS30125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AK40_RS30140	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AK40_RS30180	COG1309	transcriptional regulator
AK40_RS30185	COG1511	domain protein
AK40_RS30205	COG1609	Transcriptional regulator
AK40_RS30215	COG1234	tRNA 3'-trailer cleavage
AK40_RS30220	COG0095	Lipoate-protein ligase
AK40_RS30230	COG0318	PFAM AMP-dependent synthetase and ligase
AK40_RS30290	COG1309	transcriptional regulator
AK40_RS30295	COG1073	alpha beta
AK40_RS30300	COG1408	metallophosphoesterase
AK40_RS30310	COG1078	dGTPase activity
AK40_RS30320	COG1595	DNA-templated transcription, initiation
AK40_RS30325	COG3708	Transcriptional regulator
AK40_RS30325	COG2207	Transcriptional regulator
AK40_RS30330	COG2205	protein histidine kinase activity
AK40_RS30335	COG0745	RESPONSE REGULATOR receiver
AK40_RS30355	COG0501	Belongs to the peptidase M48B family
AK40_RS30360	COG0697	spore germination
AK40_RS30380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AK40_RS30385	COG2224	Isocitrate lyase
AK40_RS30410	COG4903	ComK protein
AK40_RS30415	COG0398	Pfam SNARE associated Golgi protein
AK40_RS30475	COG0179	Fumarylacetoacetate (FAA) hydrolase
AK40_RS30500	COG0367	asparagine synthase
AK40_RS30505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AK40_RS30510	COG0753	catalase activity
AK40_RS30515	COG0004	ammonium transporteR
AK40_RS30540	COG2996	Protein conserved in bacteria
AK40_RS30550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AK40_RS30560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AK40_RS30575	COG0561	phosphatase activity
AK40_RS30590	COG0542	response to heat
AK40_RS30600	COG2267	carboxylic ester hydrolase activity
AK40_RS30615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AK40_RS30620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AK40_RS30625	COG5504	Zn-dependent protease
AK40_RS30635	COG0180	Tryptophanyl-tRNA synthetase
AK40_RS30645	COG4166	transmembrane transport
AK40_RS30650	COG0601	transmembrane transport
AK40_RS30655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AK40_RS30660	COG0444	Belongs to the ABC transporter superfamily
AK40_RS30665	COG4608	Belongs to the ABC transporter superfamily
AK40_RS30670	COG0534	Mate efflux family protein
AK40_RS30675	COG4166	transmembrane transport
AK40_RS30695	COG0861	Integral membrane protein TerC family
AK40_RS30700	COG4862	establishment of competence for transformation
AK40_RS30705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AK40_RS30715	COG1164	Oligoendopeptidase f
AK40_RS30730	COG2346	COG2346, Truncated hemoglobins
AK40_RS30735	COG4116	CYTH
AK40_RS30745	COG2357	RelA SpoT domain protein
AK40_RS30755	COG0564	pseudouridine synthase activity
AK40_RS30770	COG0772	Belongs to the SEDS family
AK40_RS30775	COG1216	Glycosyl transferase, family 2
AK40_RS30795	COG0457	Tetratricopeptide repeat
AK40_RS30795	COG0463	Glycosyl transferase, family 2
AK40_RS30815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AK40_RS30830	COG1091	dTDP-4-dehydrorhamnose reductase activity
AK40_RS30885	COG2153	protein acetylation
AK40_RS30895	COG2382	esterase
AK40_RS30910	COG5492	domain, Protein
AK40_RS30915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AK40_RS30930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AK40_RS30930	COG0512	Glutamine amidotransferase of anthranilate synthase
AK40_RS30965	COG1620	l-lactate permease
AK40_RS30970	COG5634	Uncharacterized conserved protein (DUF2278)
AK40_RS31015	COG0508	dehydrogenase complex catalyzes the overall conversion of
AK40_RS31025	COG1476	TRANSCRIPTIONal
AK40_RS31075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AK40_RS31090	COG4152	abc transporter atp-binding protein
AK40_RS31095	COG1668	transmembrane transport
AK40_RS31115	COG2226	methyltransferase
AK40_RS31125	COG1686	Belongs to the peptidase S11 family
AK40_RS31130	COG0681	Belongs to the peptidase S26 family
AK40_RS31165	COG1012	belongs to the aldehyde dehydrogenase family
AK40_RS31175	COG1176	ABC-type spermidine putrescine transport system, permease component I
AK40_RS31180	COG1177	transmembrane transport
AK40_RS31185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AK40_RS31195	COG2409	Drug exporters of the RND superfamily
AK40_RS31205	COG0564	pseudouridine synthase activity
AK40_RS31215	COG2340	Cysteine-rich secretory protein family
AK40_RS31220	COG0247	lactate metabolic process
AK40_RS31225	COG0277	FAD linked oxidase domain protein
AK40_RS31230	COG3835	regulator
AK40_RS31240	COG0745	RESPONSE REGULATOR receiver
AK40_RS31245	COG5002	protein histidine kinase activity
AK40_RS31250	COG2186	Transcriptional regulator
AK40_RS31270	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AK40_RS31280	COG2116	formate transmembrane transporter activity
AK40_RS31285	COG0861	Integral membrane protein TerC family
AK40_RS31290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AK40_RS31300	COG2030	dehydratase
AK40_RS31320	COG1028	Short-chain dehydrogenase reductase Sdr
AK40_RS31325	COG3243	poly(R)-hydroxyalkanoic acid synthase
AK40_RS31330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AK40_RS31420	COG2376	Dihydroxyacetone kinase