locus-tag class description EJ379_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EJ379_RS00015 ENOG410848D S4 domain protein YaaA EJ379_RS00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJ379_RS00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EJ379_RS00080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) EJ379_RS00100 ENOG4105ZMH deoxynucleoside kinase EJ379_RS00110 ENOG4105GTG Isochorismatase EJ379_RS00120 ENOG4108Z6B deaminase EJ379_RS00130 ENOG4105C6E dna polymerase iii EJ379_RS00150 ENOG41067KS pro-sigma K processing EJ379_RS00185 ENOG4105CXN decarboxylase EJ379_RS00190 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EJ379_RS00195 ENOG4105FA2 dna polymerase iii EJ379_RS00200 ENOG4105MA4 psp1 domain protein EJ379_RS00210 ENOG41060K3 Methyltransferase EJ379_RS00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EJ379_RS00225 ENOG4105KRN Transcriptional regulator, abrb family EJ379_RS00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EJ379_RS00235 ENOG4105F8V Hydrolase, tatD family EJ379_RS00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) EJ379_RS00250 ENOG4105XFA sporulation peptidase YabG EJ379_RS00255 ENOG4105W42 Veg protein EJ379_RS00270 ENOG4105DFT pur operon repressor EJ379_RS00275 ENOG4105KME endoribonuclease L-psp EJ379_RS00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EJ379_RS00305 ENOG4108JA2 transcriptioN-repair coupling factor EJ379_RS00310 ENOG4108M14 stage v sporulation protein t EJ379_RS00320 ENOG4108IY2 MazG family EJ379_RS00325 ENOG41082I2 s4 domain protein EJ379_RS00330 ENOG4105VYY sporulation protein yabp EJ379_RS00345 ENOG41060GV RNA binding s1 domain protein EJ379_RS00365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EJ379_RS00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase EJ379_RS00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EJ379_RS00390 ENOG4105C6T cysteine synthase EJ379_RS00395 ENOG4105CRQ synthase (Component I) EJ379_RS00400 ENOG4105DDQ anthranilate synthase EJ379_RS00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 EJ379_RS00410 ENOG4105EEI dihydropteroate synthase EJ379_RS00415 ENOG4105KRF dihydroneopterin aldolase EJ379_RS00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EJ379_RS00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EJ379_RS00520 ENOG4108Z0C Uvrb UvrC protein EJ379_RS00535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EJ379_RS00540 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) EJ379_RS00545 ENOG4105CTP PilT protein domain protein EJ379_RS00550 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EJ379_RS00565 ENOG4105D7W serine acetyltransferase EJ379_RS00580 ENOG4105C2N RNA methyltransferase TrmH family group 3 EJ379_RS00585 ENOG4105M0M Tetracycline resistance protein EJ379_RS00590 ENOG4105QIV RNA polymerase EJ379_RS00605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EJ379_RS00610 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EJ379_RS00620 ENOG4108VZM 50s ribosomal protein L10 EJ379_RS00630 ENOG4107Y49 methyltransferase EJ379_RS00645 ENOG4105XPM ribosomal protein EJ379_RS00780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EJ379_RS00790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EJ379_RS00825 ENOG4108JJB ABC transporter EJ379_RS00830 ENOG4108JJB ABC transporter EJ379_RS00835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EJ379_RS00840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EJ379_RS00865 ENOG4105D1F ATP-binding protein EJ379_RS00880 ENOG4108NMV polysaccharide deacetylase EJ379_RS00960 ENOG4105C8B TIGR00159 family EJ379_RS00965 ENOG4107U5W ybbr family EJ379_RS00980 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EJ379_RS01005 ENOG4108PSK reductase EJ379_RS01010 ENOG4108UMI ABC transporter, permease EJ379_RS01015 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EJ379_RS01020 ENOG4105D01 (LipO)protein EJ379_RS01025 ENOG4105CB2 alcohol dehydrogenase EJ379_RS01035 ENOG4105IQ5 FAD linked oxidase domain protein EJ379_RS01050 ENOG4105C2C drug resistance transporter, Bcr CflA EJ379_RS01070 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJ379_RS01075 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ379_RS01080 ENOG4105C3U ABC transporter EJ379_RS01085 ENOG4108JQ7 (ABC) transporter EJ379_RS01115 ENOG4108J59 Extracellular solute-binding protein, family 5 EJ379_RS01120 ENOG4108J59 Extracellular solute-binding protein, family 5 EJ379_RS01140 ENOG4105E0C molybdate abc transporter EJ379_RS01145 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EJ379_RS01150 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family EJ379_RS01160 ENOG4105EGI Transcriptional regulator EJ379_RS01180 ENOG4105F6E Acyl-transferase EJ379_RS01200 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EJ379_RS01215 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) EJ379_RS01235 ENOG4105C5H ABC transporter EJ379_RS01250 ENOG4105DEF Extracellular solute-binding protein, family 5 EJ379_RS01260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ379_RS01265 ENOG4105C3U ABC transporter EJ379_RS01270 ENOG4108JQ7 (ABC) transporter EJ379_RS01275 ENOG410667J hydrolase EJ379_RS01305 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase EJ379_RS01310 ENOG4105ERH Fumarylacetoacetate hydrolase EJ379_RS01320 ENOG4105CUB amino acid EJ379_RS01325 ENOG4108SC4 )-transporter EJ379_RS01330 ENOG4105CPF Cell wall formation (By similarity) EJ379_RS01335 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EJ379_RS01360 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein EJ379_RS01365 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EJ379_RS01375 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EJ379_RS01480 ENOG4105K8N protein family UPF0079, ATPase EJ379_RS01485 ENOG41072GX Peptidase M22 Glycoprotease EJ379_RS01490 ENOG410801F ribosomal-protein-alanine acetyltransferase EJ379_RS01495 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EJ379_RS01500 ENOG4105C5H ABC transporter EJ379_RS01515 ENOG4108TYN CAAX amino terminal protease family protein EJ379_RS01530 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EJ379_RS01535 ENOG4105C7N Xanthine uracil vitamin C permease EJ379_RS01545 ENOG4105BZU Histidine kinase EJ379_RS01570 ENOG4107ZXU DSBA oxidoreductase EJ379_RS01600 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJ379_RS01610 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) EJ379_RS01620 ENOG4108SHN Glycosyl transferase, family 2 EJ379_RS01640 ENOG4105SX7 Transporter EJ379_RS01670 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EJ379_RS01675 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EJ379_RS01680 ENOG4105C83 adenylosuccinate lyase EJ379_RS01690 ENOG4105VR9 phosphoribosylformylglycinamidine synthase EJ379_RS01700 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EJ379_RS01715 ENOG4108V3E phosphoribosylglycinamide formyltransferase EJ379_RS01720 ENOG4105DC1 bifunctional purine biosynthesis protein purh EJ379_RS01725 ENOG4105C12 Phosphoribosylglycinamide synthetase EJ379_RS01755 ENOG4105C4R Atp-dependent dna helicase EJ379_RS01760 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EJ379_RS01780 ENOG4108W2Y isochorismatase EJ379_RS01790 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EJ379_RS01795 ENOG4108UMI ABC transporter, permease EJ379_RS01800 ENOG4105D01 (LipO)protein EJ379_RS01805 ENOG4107I77 yiaA/B two helix domain EJ379_RS01815 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJ379_RS01825 ENOG4105CBD Diacylglycerol kinase EJ379_RS01835 ENOG4108JPW Aminotransferase EJ379_RS01845 ENOG4105C26 Dehydrogenase EJ379_RS01850 ENOG4105KPY Small multidrug resistance protein EJ379_RS01875 ENOG4105D9N nucleoside EJ379_RS01880 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EJ379_RS01900 ENOG4108W15 Protein of unknown function (DUF1456) EJ379_RS01920 ENOG4105DTQ mandelate racemase muconate lactonizing EJ379_RS01930 ENOG4105DFD Na H antiporter EJ379_RS01950 ENOG4105D3R alkyl hydroperoxide reductase EJ379_RS01970 ENOG4105EHG Permease protein EJ379_RS01975 ENOG4105DQ5 transport system permease protein EJ379_RS01980 ENOG4108V5C ABC transporter EJ379_RS02010 ENOG4106UIA EJ379_RS02015 ENOG4106UIA EJ379_RS02030 ENOG4105BZU Histidine kinase EJ379_RS02050 ENOG410756H nucleotidyltransferase EJ379_RS02055 ENOG4105D2S major facilitator superfamily EJ379_RS02070 ENOG4105E5Q amino acid AbC transporter EJ379_RS02075 ENOG4105EAB amino acid AbC transporter EJ379_RS02080 ENOG4105CDA abc transporter atp-binding protein EJ379_RS02085 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_RS02100 ENOG4105DBV ornithine carbamoyltransferase EJ379_RS02110 ENOG4105C5B carbamate kinase EJ379_RS02115 ENOG4108W63 CRP FNR family transcriptional regulator EJ379_RS02125 ENOG4105DNP FAD linked oxidase domain protein EJ379_RS02135 ENOG4105CI1 PTS System EJ379_RS02150 ENOG4105C9U ATP-dependent DNA helicase RecQ EJ379_RS02155 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase EJ379_RS02160 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EJ379_RS02165 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter EJ379_RS02185 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EJ379_RS02190 ENOG4105D2X ABC transporter substrate-binding protein EJ379_RS02235 ENOG41062JF Transcriptional regulator EJ379_RS02250 ENOG4105DEU major facilitator superfamily EJ379_RS02265 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EJ379_RS02280 ENOG4108N0M stress protein EJ379_RS02285 ENOG4106FN3 tellurium resistance protein EJ379_RS02290 ENOG4106FN3 tellurium resistance protein EJ379_RS02295 ENOG4107TS3 membrane protein, TerC EJ379_RS02300 ENOG4108TTB tellurium resistance protein EJ379_RS02320 ENOG4105KJF protein tyrosine phosphatase EJ379_RS02330 ENOG4107U9T Pfam:Ribonuclease_BN EJ379_RS02335 ENOG4105C59 p-type ATPase EJ379_RS02340 ENOG4108IPJ Membrane EJ379_RS02350 ENOG4105C3F Signal peptidase i EJ379_RS02360 ENOG4107ZTW SNARE associated Golgi EJ379_RS02375 ENOG410606W general stress protein EJ379_RS02380 ENOG4105UPD Calcium Proton EJ379_RS02415 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EJ379_RS02430 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EJ379_RS02440 ENOG4108JUB Transcriptional regulator EJ379_RS02450 ENOG4108IQI permease EJ379_RS02490 ENOG4108A04 Beta-lactamase EJ379_RS02505 ENOG4105CKK Glycosyl transferase, family 2 EJ379_RS02510 ENOG4107QQG Dehydrogenase EJ379_RS02515 ENOG4105C3I Nad-dependent epimerase dehydratase EJ379_RS02535 ENOG4105F1A Pyruvate formate-lyase EJ379_RS02540 ENOG4108QBV Monogalactosyldiacylglycerol synthase EJ379_RS02555 ENOG4105CI2 imidazolone-5-propionate hydrolase EJ379_RS02560 ENOG4105ECP epimerase EJ379_RS02590 ENOG41067AE Membrane-bound metal-dependent hydrolase EJ379_RS02595 ENOG4105CEN a g-specific adenine glycosylase EJ379_RS02600 ENOG4106BXE EJ379_RS02620 ENOG4105BZ1 (ABC) transporter EJ379_RS02625 ENOG4107NBY Membrane EJ379_RS02630 ENOG4105CBC glutamate synthase EJ379_RS02640 ENOG4108IUW ABC transporter EJ379_RS02660 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EJ379_RS02665 ENOG4105G5W regulator Fur family EJ379_RS02785 ENOG4108JQC penicillin-binding protein 1A EJ379_RS02790 ENOG4108R9S DSBA oxidoreductase EJ379_RS02800 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EJ379_RS02810 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EJ379_RS02815 ENOG4105BZU Histidine kinase EJ379_RS02820 ENOG4105CYN Serine protein kinase EJ379_RS02825 ENOG4106AKX UPF0229 protein EJ379_RS02840 ENOG4105C94 Transporter EJ379_RS02855 ENOG4105DZ6 Band 7 protein EJ379_RS02865 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EJ379_RS02870 ENOG4108V9W transcriptional regulatory protein EJ379_RS02875 ENOG4105D4T Citrate transporter EJ379_RS02895 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EJ379_RS02900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ379_RS02905 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EJ379_RS02910 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component EJ379_RS02915 ENOG4105BZ7 extracellular solute-binding protein family 1 EJ379_RS02920 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EJ379_RS02925 ENOG4108STX response regulator EJ379_RS02930 ENOG4105US7 Histidine kinase EJ379_RS02955 ENOG4108MRH transcriptional regulatory protein EJ379_RS02965 ENOG4105C6K Malic enzyme EJ379_RS02975 ENOG4108UZ3 Transporter EJ379_RS02980 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJ379_RS02990 ENOG4105BZU Histidine kinase EJ379_RS02995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS03000 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJ379_RS03005 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EJ379_RS03010 ENOG4108JB9 formate dehydrogenase EJ379_RS03030 ENOG4105CUB amino acid EJ379_RS03040 ENOG4105C59 p-type ATPase EJ379_RS03045 ENOG4105DAP Nicotinate phosphoribosyltransferase EJ379_RS03095 ENOG41073R8 VanW family EJ379_RS03100 ENOG4108KGH TRANSCRIPTIONal EJ379_RS03105 ENOG4105D9N nucleoside EJ379_RS03110 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EJ379_RS03115 ENOG4105C37 (CBS) domain EJ379_RS03120 ENOG4108IJ0 Aspartate ammonia-lyase EJ379_RS03125 ENOG4105DAA L-lactate EJ379_RS03145 ENOG4105DUX Transporter EJ379_RS03150 ENOG4108MES Periplasmic binding protein EJ379_RS03155 ENOG4105DQ5 transport system permease protein EJ379_RS03160 ENOG4108IHU transport system permease protein EJ379_RS03165 ENOG4105E0A ABC, transporter EJ379_RS03175 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EJ379_RS03180 ENOG4105EXW epimerase dehydratase EJ379_RS03190 ENOG4107T89 von Willebrand factor, type A EJ379_RS03195 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EJ379_RS03200 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EJ379_RS03210 ENOG4105BZU Histidine kinase EJ379_RS03215 ENOG4105D5Q Arginine ornithine antiporter EJ379_RS03220 ENOG4107414 GntR family transcriptional regulator EJ379_RS03225 ENOG4105C5Y PTS System EJ379_RS03230 ENOG4105CG3 alpha amylase, catalytic region EJ379_RS03245 ENOG4105E1K spore germination protein EJ379_RS03255 ENOG4105CRN Aminoglycoside phosphotransferase EJ379_RS03260 ENOG4105BZG amino acid carrier protein EJ379_RS03265 ENOG4105CDA abc transporter atp-binding protein EJ379_RS03270 ENOG4105CT1 (ABC) transporter EJ379_RS03275 ENOG4105EAD ABC transporter EJ379_RS03280 ENOG4105DRP amino acid AbC transporter EJ379_RS03285 ENOG4108IQI permease EJ379_RS03310 ENOG4105D29 Helix-turn-helix type 11 domain protein EJ379_RS03315 ENOG4105NAE bifunctional deaminase-reductase domain protein EJ379_RS03320 ENOG4105BZU Histidine kinase EJ379_RS03325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS03335 ENOG4105CHH sulfate transporter EJ379_RS03340 ENOG41068KF Universal stress protein EJ379_RS03350 ENOG4105CXY transporter EJ379_RS03355 ENOG41067TZ transcriptional regulator, MarR family EJ379_RS03360 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ379_RS03365 ENOG4105ETE Transcriptional regulator (LacI family EJ379_RS03370 ENOG4108RVA ribokinase EJ379_RS03375 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EJ379_RS03380 ENOG4105C2J ABC transporter EJ379_RS03385 ENOG4105CNN ABC, transporter EJ379_RS03390 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EJ379_RS03395 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EJ379_RS03435 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) EJ379_RS03465 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EJ379_RS03470 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EJ379_RS03475 ENOG41069ER domain protein EJ379_RS03480 ENOG4105VZ8 Transcriptional regulator EJ379_RS03485 ENOG4107D63 EJ379_RS03500 ENOG4105DUX Transporter EJ379_RS03520 ENOG4105C85 amino acid EJ379_RS03525 ENOG4105C7N Xanthine uracil vitamin C permease EJ379_RS03540 ENOG4105MA6 gCN5-related N-acetyltransferase EJ379_RS03565 ENOG4105BZ9 Cytochrome C oxidase, subunit I EJ379_RS03570 ENOG4105E2S oxidase) subunit II EJ379_RS03590 ENOG4106CAD Protein of unknown function (DUF3311) EJ379_RS03595 ENOG4105E1V na solute symporter EJ379_RS03610 ENOG4108NHD germination protein EJ379_RS03615 ENOG4105CE1 Ferrous iron transport protein b EJ379_RS03620 ENOG4105CE1 Ferrous iron transport protein b EJ379_RS03625 ENOG4105CE1 Ferrous iron transport protein b EJ379_RS03630 ENOG4105CVA phosphate EJ379_RS03635 ENOG4105C8U phosphate abc transporter EJ379_RS03640 ENOG4105E2Z phosphate ABC transporter (Permease EJ379_RS03770 ENOG41080XQ Signal transduction protein with cbs domains EJ379_RS03790 ENOG4105ETU transcriptional activator (TenA EJ379_RS03800 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EJ379_RS03810 ENOG4108VEU Thiamine monophosphate synthase EJ379_RS03815 ENOG41080HI glycine oxidase EJ379_RS03825 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EJ379_RS03830 ENOG4105D06 uba thif-type nad fad binding protein EJ379_RS03835 ENOG4105DWF phosphomethylpyrimidine kinase EJ379_RS03865 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EJ379_RS03870 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EJ379_RS03885 ENOG4108INS Transcriptional regulator EJ379_RS03910 ENOG4105C19 ABC transporter EJ379_RS03925 ENOG4105CNN ABC, transporter EJ379_RS03940 ENOG4105C7N Xanthine uracil vitamin C permease EJ379_RS03950 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EJ379_RS03970 ENOG4105C5Y PTS System EJ379_RS03985 ENOG4105K63 Thioredoxin EJ379_RS04005 ENOG4108B31 Spore germination protein EJ379_RS04025 ENOG4107Y03 Nitroreductase EJ379_RS04030 ENOG4105ED1 spovr family EJ379_RS04040 ENOG4108TCS Glutamyl endopeptidase EJ379_RS04050 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase EJ379_RS04055 ENOG4105XTG Pfam:DUF156 EJ379_RS04060 ENOG4105VFE sira family EJ379_RS04065 ENOG4107TPS domain protein EJ379_RS04070 ENOG4105VFE sira family EJ379_RS04075 ENOG4105VFE sira family EJ379_RS04080 ENOG41085GJ domain protein EJ379_RS04085 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EJ379_RS04090 ENOG41087NI Sulfite exporter TauE/SafE EJ379_RS04100 ENOG4108KGH TRANSCRIPTIONal EJ379_RS04130 ENOG4105EMD TRANSCRIPTIONal EJ379_RS04135 ENOG4105VCP PTS System EJ379_RS04140 ENOG4105VZJ PTS System EJ379_RS04165 ENOG41069ER domain protein EJ379_RS04170 ENOG4107RBB ABC transporter, permease EJ379_RS04175 ENOG4105C19 ABC transporter EJ379_RS04205 ENOG4105WEF catalase EJ379_RS04240 ENOG4107T5V SNARE associated Golgi EJ379_RS04275 ENOG4107RWR Sodium hydrogen exchanger EJ379_RS04285 ENOG4106KNT transcriptional regulator EJ379_RS04290 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EJ379_RS04325 ENOG4108YXU transcriptional regulator AsnC family EJ379_RS04330 ENOG4105CH7 arginosuccinase EJ379_RS04335 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EJ379_RS04380 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) EJ379_RS04385 ENOG4105E5W Transporter EJ379_RS04395 ENOG4107RKG DJ-1/PfpI family EJ379_RS04400 ENOG4105CH6 catalase EJ379_RS04410 ENOG4105D5Q Arginine ornithine antiporter EJ379_RS04415 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EJ379_RS04425 ENOG4105C26 Dehydrogenase EJ379_RS04440 ENOG4105BZ1 (ABC) transporter EJ379_RS04445 ENOG4105BZ1 (ABC) transporter EJ379_RS04460 ENOG4105DRP amino acid AbC transporter EJ379_RS04465 ENOG4105CDA abc transporter atp-binding protein EJ379_RS04480 ENOG410839P EJ379_RS04490 ENOG4108UH6 UPF0754 membrane protein EJ379_RS04500 ENOG4105BZU Histidine kinase EJ379_RS04505 ENOG4105WH1 Two component transcriptional regulator luxr family EJ379_RS04515 ENOG4107FQX Alpha-acetolactate decarboxylase EJ379_RS04525 ENOG4108VX5 3-methyladenine DNA glycosylase EJ379_RS04540 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EJ379_RS04545 ENOG4105D4P Coproporphyrinogen iii oxidase EJ379_RS04550 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_RS04565 ENOG4105CHH sulfate transporter EJ379_RS04590 ENOG4105CGU Enoyl-CoA hydratase EJ379_RS04610 ENOG4105DER m42 family EJ379_RS04630 ENOG4105CTU Proline racemase EJ379_RS04635 ENOG4105CIF Ornithine Cyclodeaminase EJ379_RS04650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ379_RS04660 ENOG4108JQ7 (ABC) transporter EJ379_RS04710 ENOG4108IBT Inherit from COG: transposase EJ379_RS04780 ENOG4105CSH Transporter EJ379_RS04790 ENOG4108MRH transcriptional regulatory protein EJ379_RS04895 ENOG4105CDU Replicative dna helicase EJ379_RS04915 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ379_RS04930 ENOG4105D9U N-acetyltransferase EJ379_RS04955 ENOG4105F6J Alpha beta hydrolase fold EJ379_RS04995 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EJ379_RS05010 ENOG4105CMT Dihydroxyacetone kinase EJ379_RS05025 ENOG4105CMT Dihydroxyacetone kinase EJ379_RS05135 ENOG4105WN5 stage II sporulation protein EJ379_RS05145 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_RS05155 ENOG4108MJI response regulator EJ379_RS05160 ENOG4105BZU Histidine kinase EJ379_RS05165 ENOG4105BZU Histidine kinase EJ379_RS05205 ENOG4107QHE Choloylglycine hydrolase EJ379_RS05225 ENOG4107VRP DNA repair exonuclease EJ379_RS05230 ENOG4106D4I domain protein EJ379_RS05245 ENOG410829K Lysine exporter protein (Lyse ygga) EJ379_RS05265 ENOG4108MUZ hydrolase EJ379_RS05290 ENOG4105F0F Oxalate decarboxylase EJ379_RS05295 ENOG41067QW Transcriptional regulator EJ379_RS05300 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EJ379_RS05315 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EJ379_RS05335 ENOG4105EEM helicase EJ379_RS05345 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EJ379_RS05375 ENOG4105K59 histidine triad (HIT) protein EJ379_RS05405 ENOG410905X membrane-flanked domain protein EJ379_RS05410 ENOG4105CKV Membrane EJ379_RS05450 ENOG410905X membrane-flanked domain protein EJ379_RS05455 ENOG4105CKV Membrane EJ379_RS05460 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation EJ379_RS05465 ENOG4105BZ4 penicillin-binding protein EJ379_RS05475 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EJ379_RS05480 ENOG4105C1Q protoporphyrinogen oxidase EJ379_RS05505 ENOG4105NA0 Transcriptional regulator EJ379_RS05520 ENOG4105ECB domain protein EJ379_RS05540 ENOG4108MK9 spermidine N(1)-acetyltransferase EJ379_RS05550 ENOG4106AXD EJ379_RS05555 ENOG4108RQ5 Beta-lactamase domain-containing protein EJ379_RS05560 ENOG4105DF9 Lipoate-protein, ligase EJ379_RS05570 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_RS05580 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EJ379_RS05585 ENOG4108I5D sulfate abc transporter EJ379_RS05590 ENOG4105ECW sulfate abc transporter EJ379_RS05595 ENOG4108IJ6 ABC transporter EJ379_RS05705 ENOG4107RN3 metallophosphoesterase EJ379_RS05710 ENOG4107TVP HD domain protein EJ379_RS05720 ENOG4108AEY RNA polymerase sigma factor EJ379_RS05725 ENOG41086D8 Transcriptional regulator EJ379_RS05740 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJ379_RS05760 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 EJ379_RS05765 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_RS05770 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) EJ379_RS05780 ENOG4107QP3 malate synthase g EJ379_RS05830 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination EJ379_RS05835 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EJ379_RS05880 ENOG4105ERH Fumarylacetoacetate hydrolase EJ379_RS05890 ENOG4105C8Y Acetylornithine aminotransferase EJ379_RS05905 ENOG4105CAQ asparagine synthetase EJ379_RS05910 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EJ379_RS05915 ENOG4105CH6 catalase EJ379_RS05920 ENOG4105BZU Histidine kinase EJ379_RS05945 ENOG4105QNR S1 RNA binding domain protein EJ379_RS05950 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EJ379_RS05960 ENOG4107AYK membrAne EJ379_RS05965 ENOG41073B9 EJ379_RS05975 ENOG4108KP7 hydrolase EJ379_RS05985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EJ379_RS06010 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJ379_RS06015 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EJ379_RS06030 ENOG4105C31 Tryptophanyl-tRNA synthetase EJ379_RS06050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJ379_RS06055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJ379_RS06065 ENOG4108JQ7 (ABC) transporter EJ379_RS06070 ENOG4105UQX Mate efflux family protein EJ379_RS06090 ENOG4108ZCF integral membrane protein EJ379_RS06100 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EJ379_RS06110 ENOG4105DPN Oligoendopeptidase f EJ379_RS06120 ENOG4108Z18 K06886 hemoglobin EJ379_RS06125 ENOG4105MIX Adenylate cyclase EJ379_RS06140 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EJ379_RS06145 ENOG4105EMS pseudouridine synthase EJ379_RS06165 ENOG4105K64 Glycosyl transferase, family 2 EJ379_RS06185 ENOG4107TVC Glycosyl transferase, family 2 EJ379_RS06205 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) EJ379_RS06210 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase EJ379_RS06220 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EJ379_RS06295 ENOG4105CK7 Sodium proline symporter EJ379_RS06310 ENOG4105DDQ anthranilate synthase EJ379_RS06315 ENOG4108I0Q anthranilate phosphoribosyltransferase EJ379_RS06320 ENOG4105DK0 Indole-3-glycerol phosphate synthase EJ379_RS06325 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EJ379_RS06330 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EJ379_RS06335 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EJ379_RS06400 ENOG4105C7S Dehydrogenase EJ379_RS06405 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EJ379_RS06410 ENOG4105VZ8 Transcriptional regulator EJ379_RS06460 ENOG4108NE4 EJ379_RS06495 ENOG4105VTR Integrase EJ379_RS06525 ENOG4105DZ1 carboxypeptidase EJ379_RS06530 ENOG4105VFR signal peptidase EJ379_RS06565 ENOG4105C26 Dehydrogenase EJ379_RS06570 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ379_RS06575 ENOG4105F38 ABC transporter, permease EJ379_RS06580 ENOG4105D38 putrescine abc transporter EJ379_RS06585 ENOG4108HM4 ABC transporter EJ379_RS06595 ENOG4105EYF MMPL domain protein EJ379_RS06605 ENOG4108YBP pseudouridine synthase EJ379_RS06615 ENOG4105K4I Scp-like extracellular EJ379_RS06620 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EJ379_RS06625 ENOG4105CQB FAD linked oxidase domain protein EJ379_RS06640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS06645 ENOG4105BZU Histidine kinase EJ379_RS06650 ENOG4105JXH GntR family transcriptional regulator EJ379_RS06670 ENOG4106A3R peptidase EJ379_RS06680 ENOG4108QTI )-transporter EJ379_RS06685 ENOG4107TS3 membrane protein, TerC EJ379_RS06690 ENOG4105CZN Potassium uptake protein EJ379_RS06695 ENOG410681C small acid-soluble spore protein EJ379_RS06700 ENOG4108Z7G MaoC domain protein dehydratase EJ379_RS06720 ENOG4105CHR reductase EJ379_RS06750 ENOG4105C4Y ABC transporter EJ379_RS06755 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJ379_RS06760 ENOG4107RCV ABC transporter, permease EJ379_RS06780 ENOG4105E98 transcriptional regulator DeoR family EJ379_RS06800 ENOG4105PXI polysaccharide deacetylase EJ379_RS06810 ENOG4105BZU Histidine kinase EJ379_RS06815 ENOG41090MY MarR family Transcriptional regulator EJ379_RS06825 ENOG4106DF1 EJ379_RS06830 ENOG4105BZU Histidine kinase EJ379_RS06835 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EJ379_RS06840 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase EJ379_RS06845 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EJ379_RS06890 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EJ379_RS06895 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EJ379_RS06900 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EJ379_RS06905 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family EJ379_RS06910 ENOG4105CZV ABC transporter EJ379_RS06920 ENOG4105CJ1 ABC, transporter EJ379_RS06960 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EJ379_RS06965 ENOG4105EA8 2-Nitropropane dioxygenase EJ379_RS06970 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EJ379_RS06980 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EJ379_RS07000 ENOG4105NQC Flavodoxin EJ379_RS07030 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EJ379_RS07060 ENOG4105CZN Potassium uptake protein EJ379_RS07065 ENOG41063Y9 EJ379_RS07070 ENOG4105KBJ sporulation protein ytfj EJ379_RS07090 ENOG4105CM2 brancheD-chain amino acid aminotransferase EJ379_RS07095 ENOG4105C7K acetolactate synthase EJ379_RS07100 ENOG4108ZP8 Acetolactate synthase small subunit EJ379_RS07105 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EJ379_RS07120 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EJ379_RS07130 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) EJ379_RS07135 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EJ379_RS07140 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EJ379_RS07145 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EJ379_RS07150 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EJ379_RS07155 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EJ379_RS07160 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EJ379_RS07165 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EJ379_RS07170 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase EJ379_RS07175 ENOG4107RVV histidinol phosphate phosphatase, hisj family EJ379_RS07190 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EJ379_RS07195 ENOG4105E0M Sulfatase EJ379_RS07205 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EJ379_RS07220 ENOG4107S4M Sulfate adenylate transferase EJ379_RS07225 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) EJ379_RS07230 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EJ379_RS07240 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EJ379_RS07245 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EJ379_RS07250 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein EJ379_RS07255 ENOG4105C8J )-transporter EJ379_RS07275 ENOG4105DFD Na H antiporter EJ379_RS07295 ENOG4105ENE Histidine kinase EJ379_RS07300 ENOG4105WH1 Two component transcriptional regulator luxr family EJ379_RS07320 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ379_RS07345 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EJ379_RS07365 ENOG4105CJ3 phosphate transporter EJ379_RS07370 ENOG4107GRR phosphate transport regulator EJ379_RS07375 ENOG4105BZ4 penicillin-binding protein EJ379_RS07390 ENOG4105BZU Histidine kinase EJ379_RS07395 ENOG4105I3N Conserved Protein EJ379_RS07410 ENOG4105BZU Histidine kinase EJ379_RS07415 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EJ379_RS07440 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EJ379_RS07445 ENOG4105DZ1 carboxypeptidase EJ379_RS07450 ENOG4108JIC nucleoside recognition domain protein EJ379_RS07460 ENOG4105FE9 pseudouridine synthase EJ379_RS07465 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EJ379_RS07470 ENOG4107TWT Cytochrome c biogenesis protein EJ379_RS07475 ENOG4105CRE cytochrome C EJ379_RS07480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS07485 ENOG4105BZU Histidine kinase EJ379_RS07490 ENOG4108WBT adenosyltransferase EJ379_RS07505 ENOG4108SAX Membrane EJ379_RS07520 ENOG4105C9U ATP-dependent DNA helicase RecQ EJ379_RS07525 ENOG4105I7S Abortive infection protein EJ379_RS07535 ENOG4107RGJ metallophosphoesterase EJ379_RS07540 ENOG4108XDN Transcriptional regulator EJ379_RS07545 ENOG4108S6Z Negative regulator of genetic competence EJ379_RS07570 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase EJ379_RS07575 ENOG4107RB3 L-asparaginase EJ379_RS07590 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EJ379_RS07605 ENOG4105S2F EJ379_RS07610 ENOG41065D1 EJ379_RS07640 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) EJ379_RS07655 ENOG4105XXQ heptaprenyl diphosphate synthase component I EJ379_RS07665 ENOG4105EAH synthase EJ379_RS07670 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EJ379_RS07675 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EJ379_RS07680 ENOG4105D49 3-dehydroquinate synthase EJ379_RS07690 ENOG41068YB TPR repeat-containing protein EJ379_RS07705 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) EJ379_RS07710 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EJ379_RS07745 ENOG4108JYZ YitT family EJ379_RS07755 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase EJ379_RS07760 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EJ379_RS07770 ENOG4105FJR Lmbe family EJ379_RS07775 ENOG4105CPK Glycosyl transferase (Group 1 EJ379_RS07795 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EJ379_RS07800 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EJ379_RS07810 ENOG4105DVT helicase EJ379_RS07815 ENOG4105YAC EJ379_RS07835 ENOG4105CSM endonuclease III EJ379_RS07905 ENOG4106F55 Protein of unknown function (DUF1273) EJ379_RS07920 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EJ379_RS07930 ENOG4105DVT helicase EJ379_RS07935 ENOG4105CTD carboxy-peptidase EJ379_RS07945 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EJ379_RS07950 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) EJ379_RS07955 ENOG4105C2W permease EJ379_RS07960 ENOG4105DHF Membrane EJ379_RS07965 ENOG410890F Dynamin family EJ379_RS07975 ENOG4108W0I acetyltransferase EJ379_RS07985 ENOG4105KHC sulfurtransferase EJ379_RS08040 ENOG4105HTX biosynthesis protein EJ379_RS08070 ENOG4105CPK Glycosyl transferase (Group 1 EJ379_RS08085 ENOG4108SZE gCN5-related N-acetyltransferase EJ379_RS08105 ENOG41081VK Ribonuclease EJ379_RS08170 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJ379_RS08180 ENOG4107RWR Sodium hydrogen exchanger EJ379_RS08185 ENOG4105CN5 Metallo-Beta-Lactamase EJ379_RS08190 ENOG4108Z5V transcriptional regulator, merr family EJ379_RS08200 ENOG4105H67 Protein of unknown function (DUF421) EJ379_RS08205 ENOG41080C8 DUF218 domain EJ379_RS08240 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EJ379_RS08250 ENOG4107R0U MotA TolQ exbB proton channel EJ379_RS08255 ENOG4105ER2 Ompa motb domain protein EJ379_RS08260 ENOG4107YTP response regulator receiver protein EJ379_RS08265 ENOG4105CBS Chea signal transduction histidine kinase EJ379_RS08270 ENOG4105DD5 Flagellar motor switch protein EJ379_RS08285 ENOG4105BZU Histidine kinase EJ379_RS08305 ENOG4105E1Q flagellar hook-associated protein EJ379_RS08310 ENOG4105DTJ flagellar hook-associated protein EJ379_RS08315 ENOG4107TPX flagellar hook-associated EJ379_RS08330 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EJ379_RS08335 ENOG4108ZC9 flagellar basal-body rod protein flgc EJ379_RS08345 ENOG4107U2N Flagellar M-ring protein EJ379_RS08350 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EJ379_RS08380 ENOG4105BZE flagellar hook protein, FlgE EJ379_RS08395 ENOG4107R88 Chemotaxis protein (CheV) EJ379_RS08410 ENOG4105I03 Flagellin EJ379_RS08415 ENOG4105I03 Flagellin EJ379_RS08420 ENOG4105I03 Flagellin EJ379_RS08425 ENOG4105I03 Flagellin EJ379_RS08430 ENOG4105E4C Lytic transglycosylase catalytic EJ379_RS08440 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EJ379_RS08445 ENOG4105DD5 Flagellar motor switch protein EJ379_RS08455 ENOG4105CN7 Flagellar biosynthetic protein FliP EJ379_RS08460 ENOG4105VS8 Flagellar biosynthetic protein fliq EJ379_RS08470 ENOG4105D00 flagellar biosynthetic protein flhB EJ379_RS08475 ENOG4105D7B Flagellar biosynthesis protein flha EJ379_RS08480 ENOG4105FZW flagellar biosynthesis regulator FlhF EJ379_RS08485 ENOG4105KTQ flagellar basal-body rod protein EJ379_RS08490 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EJ379_RS08525 ENOG4105KAC Antibiotic biosynthesis monooxygenase EJ379_RS08565 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component EJ379_RS08600 ENOG4105CVJ phosphoglycerate mutase EJ379_RS08610 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EJ379_RS08630 ENOG4105CAQ asparagine synthetase EJ379_RS08650 ENOG4105PGM cation diffusion facilitator family transporter EJ379_RS08660 ENOG4105DRR Transcriptional regulator, GntR family EJ379_RS08665 ENOG4108UZ3 Transporter EJ379_RS08675 ENOG4105CKI cobalamin synthesis protein EJ379_RS08680 ENOG4108PJD permease EJ379_RS08695 ENOG4105DFD Na H antiporter EJ379_RS08700 ENOG4105VUF Transcriptional regulator EJ379_RS08710 ENOG4105C9Q fumarate hydratase class II EJ379_RS08725 ENOG4107QJQ Mate efflux family protein EJ379_RS08730 ENOG4105EC3 peptidase S51, dipeptidase E EJ379_RS08750 ENOG4107QIV Cytochrome c biogenesis protein EJ379_RS08770 ENOG4105BZC d-serine deaminase EJ379_RS08775 ENOG4106BRA Membrane EJ379_RS08815 ENOG4105CJ1 ABC, transporter EJ379_RS08835 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EJ379_RS08845 ENOG4108IJ0 Aspartate ammonia-lyase EJ379_RS08850 ENOG4105C6K Malic enzyme EJ379_RS08910 ENOG4105FVX EJ379_RS08915 ENOG4105E09 nadh pyrophosphatase EJ379_RS08930 ENOG4105CSR polyphosphate kinase 2 EJ379_RS08935 ENOG4105U3E Transcriptional regulator EJ379_RS08950 ENOG4105DXI Major Facilitator superfamily EJ379_RS08960 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EJ379_RS08965 ENOG4105EU0 Major facilitator Superfamily EJ379_RS08970 ENOG4105C6T cysteine synthase EJ379_RS08990 ENOG4105C8J )-transporter EJ379_RS09000 ENOG4105X5K response regulator receiver protein EJ379_RS09005 ENOG4105H67 Protein of unknown function (DUF421) EJ379_RS09025 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EJ379_RS09030 ENOG4105CHR reductase EJ379_RS09035 ENOG4105CM2 brancheD-chain amino acid aminotransferase EJ379_RS09040 ENOG4105C7K acetolactate synthase EJ379_RS09050 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EJ379_RS09055 ENOG4105C01 Dihydroxy-acid dehydratase EJ379_RS09060 ENOG4105C7B Threonine dehydratase EJ379_RS09085 ENOG4105C6X Major Facilitator EJ379_RS09090 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EJ379_RS09100 ENOG4105DY9 regulatoR EJ379_RS09105 ENOG4105CYC Transferase EJ379_RS09120 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJ379_RS09150 ENOG41068WN EJ379_RS09170 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EJ379_RS09185 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EJ379_RS09190 ENOG4105C0X amino acid EJ379_RS09225 ENOG410849A acetyltransferase, (GNAT) family EJ379_RS09235 ENOG4105K8R UPF0145 protein EJ379_RS09250 ENOG4107RHR regulatoR EJ379_RS09260 ENOG4105D9N nucleoside EJ379_RS09265 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EJ379_RS09290 ENOG4107RAQ aminopeptidase EJ379_RS09300 ENOG4107R16 Multicopper oxidase EJ379_RS09345 ENOG4108T5E Copper resistance protein EJ379_RS09350 ENOG4105KTB nuclear export factor GLE1 EJ379_RS09355 ENOG4107RT3 EamA-like transporter family EJ379_RS09360 ENOG4105GZI Transcriptional regulator EJ379_RS09365 ENOG4108Z40 Transcriptional regulator EJ379_RS09370 ENOG4107ZXU DSBA oxidoreductase EJ379_RS09375 ENOG4108TVJ Nitroreductase EJ379_RS09380 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJ379_RS09470 ENOG4105C2M dna polymerase I EJ379_RS09575 ENOG4105KRN Transcriptional regulator, abrb family EJ379_RS09710 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis EJ379_RS09790 ENOG4106F5Q Membrane EJ379_RS09795 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EJ379_RS09810 ENOG4105CKI cobalamin synthesis protein EJ379_RS09820 ENOG4105C0Z ABC transporter EJ379_RS09825 ENOG4108IV0 ABC, transporter EJ379_RS09830 ENOG4105C32 Amino acid ABC transporter (Permease) EJ379_RS09840 ENOG4105SKE transcriptional Regulator LysR family EJ379_RS09860 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes EJ379_RS09870 ENOG4105C4M (Ubiquinol oxidase) subunit I EJ379_RS09875 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EJ379_RS09880 ENOG4108JJ9 ABC, transporter EJ379_RS09885 ENOG4108JJ8 (ABC) transporter EJ379_RS09895 ENOG4105K64 Glycosyl transferase, family 2 EJ379_RS09905 ENOG4108UT6 Transferase hexapeptide repeat containing protein EJ379_RS09960 ENOG4105BZ1 (ABC) transporter EJ379_RS09965 ENOG4105EFI regulatoR EJ379_RS09970 ENOG4105BZU Histidine kinase EJ379_RS09980 ENOG41075D4 Aminoglycoside 6-adenylyltransferase EJ379_RS10005 ENOG4105D6E homoserine dehydrogenase EJ379_RS10015 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EJ379_RS10030 ENOG4108KGH TRANSCRIPTIONal EJ379_RS10040 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJ379_RS10045 ENOG4105BZU Histidine kinase EJ379_RS10060 ENOG4105KT7 mgtC SapB transporter EJ379_RS10065 ENOG4105VRR gCN5-related N-acetyltransferase EJ379_RS10075 ENOG4105DUU IucA IucC family protein EJ379_RS10080 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_RS10095 ENOG4108WBH protein TIM barrel EJ379_RS10100 ENOG4105YWU small acid-soluble spore protein EJ379_RS10110 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EJ379_RS10115 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJ379_RS10165 ENOG4105KRN Transcriptional regulator, abrb family EJ379_RS10175 ENOG4105YVS arsR family transcriptional regulator EJ379_RS10180 ENOG4105CPC Aldo Keto reductase EJ379_RS10185 ENOG4107XZQ multidrug resistance protein EJ379_RS10195 ENOG4105KAF membrAne EJ379_RS10220 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_RS10235 ENOG4108K88 Membrane EJ379_RS10240 ENOG4108WPJ Ferritin-like domain EJ379_RS10255 ENOG4105DEN Luciferase family EJ379_RS10270 ENOG4105VMI -acetyltransferase EJ379_RS10275 ENOG4107QM2 Aldo Keto reductase EJ379_RS10280 ENOG4105CKI cobalamin synthesis protein EJ379_RS10290 ENOG4105DSE periplasmic solute binding protein EJ379_RS10295 ENOG4105K4T epimerase EJ379_RS10300 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJ379_RS10305 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EJ379_RS10350 ENOG4107T5V SNARE associated Golgi EJ379_RS10365 ENOG4108PJD permease EJ379_RS10375 ENOG4108S4H thioesterase Superfamily protein EJ379_RS10385 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EJ379_RS10405 ENOG4105SXS Protein of unknown function (DUF456) EJ379_RS10410 ENOG4105C37 (CBS) domain EJ379_RS10430 ENOG4108Z7R Chaperone CsaA EJ379_RS10450 ENOG4108ZRV stage ii sporulation protein p EJ379_RS10460 ENOG4108VXD carboxy-peptidase EJ379_RS10470 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJ379_RS10490 ENOG4108ZRV stage ii sporulation protein p EJ379_RS10500 ENOG4108X4Q Hydrolase EJ379_RS10515 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EJ379_RS10535 ENOG41087PP glycosyltransferase MGT family EJ379_RS10540 ENOG4108JYZ YitT family EJ379_RS10545 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJ379_RS10575 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJ379_RS10610 ENOG4108MGT Required for secretion of EsxA and EsxB EJ379_RS10700 ENOG4105KBJ sporulation protein ytfj EJ379_RS10725 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJ379_RS10730 ENOG4105CKU formyltetrahydrofolate synthetase EJ379_RS10745 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EJ379_RS10750 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily EJ379_RS10760 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJ379_RS10765 ENOG4105EMN RNA polymerase sigma factor EJ379_RS10775 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) EJ379_RS10785 ENOG4105CNW domain protein EJ379_RS10795 ENOG4108V06 Glutathione peroxidase EJ379_RS10810 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJ379_RS10820 ENOG4108IUE nitrate reductase beta subunit EJ379_RS10825 ENOG4105R3A Nitrate reductase EJ379_RS10835 ENOG4107V6Q Cyclic nucleotide-binding domain EJ379_RS10840 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJ379_RS10845 ENOG4105D06 uba thif-type nad fad binding protein EJ379_RS10850 ENOG4105CVM Molybdenum cofactor synthesis domain protein EJ379_RS10855 ENOG4108ZAF Molybdopterin EJ379_RS10890 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein EJ379_RS10895 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EJ379_RS10900 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EJ379_RS10905 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit EJ379_RS10910 ENOG4108IFG nitrite reductase, (NAD(P)H) EJ379_RS10915 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) EJ379_RS10950 ENOG4105MCT stage V sporulation protein S EJ379_RS10995 ENOG4105C5H ABC transporter EJ379_RS11010 ENOG4108UUM single-stranded DNA-binding protein EJ379_RS11030 ENOG4107YX5 Pfam:DUF548 EJ379_RS11035 ENOG4105C75 arginyL-tRNA synthetase EJ379_RS11065 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EJ379_RS11095 ENOG4105C5S asparaginyl-tRNA synthetase EJ379_RS11100 ENOG4105C8J )-transporter EJ379_RS11120 ENOG4107XGZ Hydrolase EJ379_RS11125 ENOG4105CY2 Citrate transporter EJ379_RS11145 ENOG4105KD7 acetyltransferase EJ379_RS11155 ENOG4105VMP Transcriptional regulator EJ379_RS11160 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase EJ379_RS11185 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 EJ379_RS11200 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) EJ379_RS11205 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EJ379_RS11215 ENOG4107RVG penicillin-binding protein EJ379_RS11220 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EJ379_RS11225 ENOG4105E9Q Acyl-transferase EJ379_RS11230 ENOG4108UT2 hemolysin iii EJ379_RS11240 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EJ379_RS11250 ENOG4108RCR degv family EJ379_RS11260 ENOG4108KF3 Electron transport protein SCO1 SenC EJ379_RS11265 ENOG4107Y70 Heat shock protein EJ379_RS11270 ENOG4105CAQ asparagine synthetase EJ379_RS11285 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EJ379_RS11290 ENOG4108MES Periplasmic binding protein EJ379_RS11295 ENOG4105F0I Aminotransferase EJ379_RS11330 ENOG4105D8X mechanosensitive ion channel EJ379_RS11335 ENOG4105BZU Histidine kinase EJ379_RS11340 ENOG4105WH1 Two component transcriptional regulator luxr family EJ379_RS11345 ENOG4106KNT transcriptional regulator EJ379_RS11350 ENOG4107ZY0 Phenazine biosynthesis-like protein EJ379_RS11370 ENOG4105CMG Carbohydrate kinase EJ379_RS11375 ENOG4105C6Z Gluconate EJ379_RS11385 ENOG4108YV3 Protein of unknown function (DUF2711) EJ379_RS11415 ENOG4108IJ8 ABC transporter EJ379_RS11420 ENOG4105E90 ABC transporter EJ379_RS11455 ENOG4105C37 (CBS) domain EJ379_RS11480 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJ379_RS11495 ENOG4107S4Y M20 DapE family protein YgeY EJ379_RS11500 ENOG4108TSC N-acetyltransferase EJ379_RS11505 ENOG4108JUB Transcriptional regulator EJ379_RS11510 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EJ379_RS11555 ENOG410841Q phosphoesterase PA-phosphatase related protein EJ379_RS11565 ENOG4105SZ6 Thioredoxin EJ379_RS11570 ENOG4105KNA -acetyltransferase EJ379_RS11615 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EJ379_RS11670 ENOG4105BZ4 penicillin-binding protein EJ379_RS11680 ENOG4105CZM Major Facilitator EJ379_RS11685 ENOG4105W8X HesB YadR YfhF-family protein EJ379_RS11695 ENOG4105DXD 2-methylcitrate dehydratase EJ379_RS11700 ENOG4105CR4 methylisocitrate lyase EJ379_RS11705 ENOG4105C1G acyl-Coa dehydrogenase EJ379_RS11710 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EJ379_RS11720 ENOG4105N14 lysine exporter protein LysE YggA EJ379_RS11725 ENOG4105E39 Enoyl-CoA hydratase EJ379_RS11740 ENOG4107RFY SbcCD D subunit EJ379_RS11745 ENOG4105EYH Exonuclease EJ379_RS11765 ENOG4105FCD Major Facilitator EJ379_RS11775 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EJ379_RS11780 ENOG4105E4F Isochorismate synthase EJ379_RS11785 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EJ379_RS11790 ENOG4105WQI isochorismatase EJ379_RS11795 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_RS11800 ENOG4105WQT MbtH domain protein EJ379_RS11805 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ379_RS11820 ENOG4105K70 DNA-binding protein EJ379_RS11840 ENOG4105BZG amino acid carrier protein EJ379_RS11860 ENOG4105FE9 pseudouridine synthase EJ379_RS11865 ENOG4105C22 threonyL-tRNA synthetase EJ379_RS11870 ENOG4105C19 ABC transporter EJ379_RS11905 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EJ379_RS11920 ENOG41081I9 integral membrane protein EJ379_RS11930 ENOG4108Y4K DNA-binding transcriptional activator EJ379_RS11950 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EJ379_RS11960 ENOG4105EYF MMPL domain protein EJ379_RS12000 ENOG4105WCN acetyltransferase EJ379_RS12025 ENOG4105C1Q protoporphyrinogen oxidase EJ379_RS12035 ENOG41068WN EJ379_RS12065 ENOG4107V2S Transcriptional regulator EJ379_RS12070 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EJ379_RS12090 ENOG4105DND Transcriptional regulator EJ379_RS12095 ENOG4108RPX mosc domain containing protein EJ379_RS12110 ENOG4105BZ1 (ABC) transporter EJ379_RS12115 ENOG4105BZ1 (ABC) transporter EJ379_RS12150 ENOG4108JCI Transcriptional regulator EJ379_RS12180 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) EJ379_RS12185 ENOG4108KPJ rna polymerase sigma factor EJ379_RS12210 ENOG4105F32 YngK protein EJ379_RS12230 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) EJ379_RS12235 ENOG4105RD7 BadF BadG BcrA BcrD EJ379_RS12240 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EJ379_RS12245 ENOG4107STF Involved in phosphonate degradation (By similarity) EJ379_RS12255 ENOG4108INS Transcriptional regulator EJ379_RS12275 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EJ379_RS12285 ENOG4105C1J atp-dependent rna helicase EJ379_RS12300 ENOG4108RZE Tetr family transcriptional regulator EJ379_RS12425 ENOG41088CC tellurite resistance protein tehB EJ379_RS12435 ENOG4108I0C methyltransferase EJ379_RS12440 ENOG4107RA9 decarboxylase EJ379_RS12445 ENOG4105K56 Transcriptional regulator EJ379_RS12450 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJ379_RS12475 ENOG4105CIN aminoacyl-histidine dipeptidase EJ379_RS12500 ENOG4105KRN Transcriptional regulator, abrb family EJ379_RS12510 ENOG4105EJ9 Membrane EJ379_RS12515 ENOG4105EQK -acetyltransferase EJ379_RS12555 ENOG4105W8Z 4'-phosphopantetheinyl transferase EJ379_RS12625 ENOG4105FQP Beta-lactamase EJ379_RS12630 ENOG4107RVG penicillin-binding protein EJ379_RS12645 ENOG4107RF6 penicillin-binding protein EJ379_RS12650 ENOG4107RF6 penicillin-binding protein EJ379_RS12660 ENOG4108MK9 spermidine N(1)-acetyltransferase EJ379_RS12670 ENOG4105DIN metallophosphoesterase EJ379_RS12680 ENOG4105CJ1 ABC, transporter EJ379_RS12690 ENOG4107Z3H Transcriptional regulator, TetR family EJ379_RS12705 ENOG4105C1G acyl-Coa dehydrogenase EJ379_RS12710 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EJ379_RS12715 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit EJ379_RS12720 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EJ379_RS12725 ENOG4105E39 Enoyl-CoA hydratase EJ379_RS12730 ENOG4107QX3 carboxylase EJ379_RS12735 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJ379_RS12780 ENOG4105DZ1 carboxypeptidase EJ379_RS12795 ENOG4105T9C HD domain EJ379_RS12805 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EJ379_RS12825 ENOG41075H3 AraC family transcriptional regulator EJ379_RS12855 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EJ379_RS12865 ENOG4107Y80 Major Facilitator superfamily EJ379_RS12870 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EJ379_RS12875 ENOG4105KVH Transcriptional regulator EJ379_RS12945 ENOG4105CPQ Dehydrogenase EJ379_RS12955 ENOG410900G Protein of unknown function (DUF421) EJ379_RS12960 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EJ379_RS12970 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein EJ379_RS12980 ENOG4105DK7 lysyl-tRNA synthetase EJ379_RS13045 ENOG4105D6E homoserine dehydrogenase EJ379_RS13055 ENOG4105CPF Cell wall formation (By similarity) EJ379_RS13060 ENOG4105ETU transcriptional activator (TenA EJ379_RS13090 ENOG4105VTR Integrase EJ379_RS13300 ENOG4105XSJ toxin secretion phage lysis holin EJ379_RS13375 ENOG4106A3M Cytochrome p-450 EJ379_RS13400 ENOG410667J hydrolase EJ379_RS13405 ENOG4105BZU Histidine kinase EJ379_RS13410 ENOG4107RF6 penicillin-binding protein EJ379_RS13435 ENOG4108FPN Integrase EJ379_RS13455 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EJ379_RS13470 ENOG41086D8 Transcriptional regulator EJ379_RS13505 ENOG4108NHD germination protein EJ379_RS13520 ENOG4108W2Y isochorismatase EJ379_RS13540 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EJ379_RS13550 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EJ379_RS13560 ENOG4105EKQ RNA-directed DNA polymerase EJ379_RS13610 ENOG4108JJB ABC transporter EJ379_RS13625 ENOG4108HGU Histidine kinase EJ379_RS13640 ENOG4105CB2 alcohol dehydrogenase EJ379_RS13645 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EJ379_RS13650 ENOG4105CJN penicillin-binding protein EJ379_RS13690 ENOG4108V4B ThiJ pfpI EJ379_RS13700 ENOG4107Y80 Major Facilitator superfamily EJ379_RS13715 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EJ379_RS13740 ENOG4107Y9U Membrane EJ379_RS13780 ENOG4105FCD Major Facilitator EJ379_RS13795 ENOG4105E09 nadh pyrophosphatase EJ379_RS13800 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EJ379_RS13820 ENOG4105KME endoribonuclease L-psp EJ379_RS13825 ENOG4108XI2 Domain of unknown function (DUF1963) EJ379_RS13845 ENOG4108NRW Phospholipase, patatin family EJ379_RS13850 ENOG4105KWG Pfam:DUF1696 EJ379_RS13875 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EJ379_RS13885 ENOG4105PKS Excinuclease abc c subunit domain protein EJ379_RS13915 ENOG4105CJ1 ABC, transporter EJ379_RS13935 ENOG4107VFR oxidoreductase EJ379_RS13990 ENOG4108IUM Glycogen debranching enzyme EJ379_RS14000 ENOG4105CGH 5'-nucleotidase EJ379_RS14020 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) EJ379_RS14025 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EJ379_RS14030 ENOG4105FDR Membrane EJ379_RS14040 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EJ379_RS14085 ENOG4105MSI germination protein ypeb EJ379_RS14115 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) EJ379_RS14120 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) EJ379_RS14125 ENOG4107Z3H Transcriptional regulator, TetR family EJ379_RS14160 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EJ379_RS14175 ENOG4105E98 transcriptional regulator DeoR family EJ379_RS14190 ENOG41062ES Transcriptional regulator EJ379_RS14210 ENOG4107QKR Dehydrogenase EJ379_RS14220 ENOG4107RUY (E1 component), alpha subunit EJ379_RS14230 ENOG4105E1F short-chain dehydrogenase reductase EJ379_RS14235 ENOG4105RHY Pfam:UPF0157 EJ379_RS14275 ENOG4107SQ8 Glycine betaine EJ379_RS14280 ENOG4108IJ7 Glycine betaine EJ379_RS14290 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EJ379_RS14305 ENOG4105E66 phosphoriboisomerase A EJ379_RS14310 ENOG41082BV acetyltransferase EJ379_RS14315 ENOG4108M1A Chitin-binding protein EJ379_RS14340 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJ379_RS14345 ENOG4105MSB protein, conserved in bacteria EJ379_RS14370 ENOG4108Z7F N-acetyltransferase EJ379_RS14390 ENOG4105EEM helicase EJ379_RS14405 ENOG4105C9U ATP-dependent DNA helicase RecQ EJ379_RS14460 ENOG4108M1A Chitin-binding protein EJ379_RS14480 ENOG4105BZG amino acid carrier protein EJ379_RS14485 ENOG4105C26 Dehydrogenase EJ379_RS14490 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJ379_RS14495 ENOG4105CTU Proline racemase EJ379_RS14500 ENOG4105CTU Proline racemase EJ379_RS14505 ENOG41080HI glycine oxidase EJ379_RS14515 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein EJ379_RS14545 ENOG4107T5V SNARE associated Golgi EJ379_RS14555 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EJ379_RS14575 ENOG4105DTQ mandelate racemase muconate lactonizing EJ379_RS14590 ENOG4107SET aldo keto reductase EJ379_RS14625 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) EJ379_RS14630 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EJ379_RS14635 ENOG4105BZU Histidine kinase EJ379_RS14640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS14660 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 EJ379_RS14675 ENOG4105DPN Oligoendopeptidase f EJ379_RS14680 ENOG4105EPR degv family EJ379_RS14740 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) EJ379_RS14745 ENOG4106K7D Major facilitator family transporter EJ379_RS14765 ENOG4107BMA Transglycosylase associated protein EJ379_RS14780 ENOG41089UC methyltransferase, type 11 EJ379_RS14815 ENOG4105CHM Aminotransferase EJ379_RS14845 ENOG4105DVE abc transporter atp-binding protein EJ379_RS14895 ENOG4105C02 permease EJ379_RS14905 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EJ379_RS14910 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJ379_RS14915 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein EJ379_RS14920 ENOG4105D7T ABC transporter EJ379_RS14955 ENOG4108AQF aminoglycoside N(3)-acetyltransferase EJ379_RS14995 ENOG4107VC0 DNA alkylation repair enzyme EJ379_RS15000 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase EJ379_RS15020 ENOG4108ZCF integral membrane protein EJ379_RS15025 ENOG4105E0M Sulfatase EJ379_RS15030 ENOG4105C5H ABC transporter EJ379_RS15040 ENOG4105EYF MMPL domain protein EJ379_RS15045 ENOG41082JN Transcriptional regulator EJ379_RS15065 ENOG4105CIH Imidazole acetol-phosphate transaminase EJ379_RS15070 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EJ379_RS15075 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EJ379_RS15100 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) EJ379_RS15120 ENOG41069ER domain protein EJ379_RS15130 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase EJ379_RS15160 ENOG4105D4B ABC, transporter EJ379_RS15165 ENOG4105F5R ABC transporter EJ379_RS15170 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane EJ379_RS15180 ENOG4105DKT Transcriptional regulator EJ379_RS15185 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) EJ379_RS15195 ENOG41061GT Aldolase EJ379_RS15205 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) EJ379_RS15235 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EJ379_RS15240 ENOG4105II7 pyrroline-5-carboxylate reductase EJ379_RS15250 ENOG4107258 Transcriptional regulator EJ379_RS15270 ENOG4105ECK Fatty Acid Desaturase EJ379_RS15280 ENOG4107RBI VanW family EJ379_RS15285 ENOG4105G6Z alkaline phosphatase EJ379_RS15295 ENOG4105VMP Transcriptional regulator EJ379_RS15315 ENOG41068WN EJ379_RS15350 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJ379_RS15365 ENOG4105CSH Transporter EJ379_RS15375 ENOG4105CKK Glycosyl transferase, family 2 EJ379_RS15405 ENOG4105C8Y Acetylornithine aminotransferase EJ379_RS15450 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJ379_RS15460 ENOG4108IBT Inherit from COG: transposase EJ379_RS15480 ENOG4108TVJ Nitroreductase EJ379_RS15485 ENOG4105FS7 Transcriptional regulator EJ379_RS15505 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EJ379_RS15520 ENOG4105CMR udp-glucose 4-epimerase EJ379_RS15530 ENOG4108DMH HTH_ARAC EJ379_RS15535 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EJ379_RS15540 ENOG4108XET gCN5-related N-acetyltransferase EJ379_RS15615 ENOG410635A Membrane EJ379_RS15625 ENOG4108IQI permease EJ379_RS15635 ENOG4105F1N DNA alkylation repair EJ379_RS15675 ENOG4107RF6 penicillin-binding protein EJ379_RS15680 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EJ379_RS15685 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) EJ379_RS15700 ENOG4105E7W lamb ycsf family protein EJ379_RS15710 ENOG4105P4J Allophanate hydrolase, subunit 1 EJ379_RS15715 ENOG4107258 Transcriptional regulator EJ379_RS15725 ENOG4106N3A copper homeostasis protein cutc EJ379_RS15730 ENOG4108ZHR arsR family transcriptional regulator EJ379_RS15740 ENOG4105FDT acyl-CoA dehydrogenase EJ379_RS15755 ENOG4105DWD nucleoside recognition domain protein EJ379_RS15800 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EJ379_RS15825 ENOG4105E2A Dehydrogenase EJ379_RS15830 ENOG4108IJ0 Aspartate ammonia-lyase EJ379_RS15835 ENOG4105HDK L-asparaginase EJ379_RS15840 ENOG4108IMY Transcriptional regulator EJ379_RS15865 ENOG4108B31 Spore germination protein EJ379_RS15875 ENOG4105BZU Histidine kinase EJ379_RS15900 ENOG41075H3 AraC family transcriptional regulator EJ379_RS15915 ENOG4105YWU small acid-soluble spore protein EJ379_RS15920 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EJ379_RS15925 ENOG4105CUB amino acid EJ379_RS15930 ENOG4105II7 pyrroline-5-carboxylate reductase EJ379_RS15935 ENOG4108NHD germination protein EJ379_RS15940 ENOG4108Q8B Spore germination protein EJ379_RS15975 ENOG4106A3M Cytochrome p-450 EJ379_RS15995 ENOG4105CGH 5'-nucleotidase EJ379_RS16005 ENOG4105CHJ isochorismatase hydrolase EJ379_RS16030 ENOG41090MY MarR family Transcriptional regulator EJ379_RS16055 ENOG4105F6J Alpha beta hydrolase fold EJ379_RS16070 ENOG4108606 TspO/MBR family EJ379_RS16075 ENOG4105CVP deoxyribo-dipyrimidine photolyase EJ379_RS16100 ENOG4108TWJ NADH dehydrogenase subunit 5 EJ379_RS16105 ENOG4105GPN Uncharacterized conserved protein (DUF2294) EJ379_RS16125 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EJ379_RS16130 ENOG4105ECQ AraC Family Transcriptional Regulator EJ379_RS16135 ENOG4105Z7P Acetyltransferase (GNAT) family EJ379_RS16140 ENOG4108SY2 LMWPc EJ379_RS16145 ENOG4105D6J arsenicaL-resistance protein EJ379_RS16150 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase EJ379_RS16155 ENOG41085FC arsR family transcriptional regulator EJ379_RS16165 ENOG4105NAE bifunctional deaminase-reductase domain protein EJ379_RS16170 ENOG4107P5I polyketide synthase EJ379_RS16175 ENOG4108IG5 Transcriptional regulator EJ379_RS16190 ENOG4105EQ0 Major Facilitator superfamily EJ379_RS16195 ENOG4108JGH Tetr family transcriptional regulator EJ379_RS16205 ENOG4105XRQ Xanthine dehydrogenase accessory factor EJ379_RS16220 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding EJ379_RS16250 ENOG4105CHR reductase EJ379_RS16255 ENOG4108YXU transcriptional regulator AsnC family EJ379_RS16335 ENOG4105C44 Serine transporter EJ379_RS16345 ENOG4105DWP Membrane EJ379_RS16395 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS16400 ENOG41062D9 Histidine kinase EJ379_RS16445 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EJ379_RS16450 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ379_RS16470 ENOG4105K6H D-cysteine desulfhydrase EJ379_RS16485 ENOG4105JQZ Methyltransferase EJ379_RS16505 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) EJ379_RS16525 ENOG4105BZU Histidine kinase EJ379_RS16535 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EJ379_RS16545 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EJ379_RS16600 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) EJ379_RS16610 ENOG4105DVH amino acid EJ379_RS16630 ENOG4108JQ1 Dehydrogenase EJ379_RS16635 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EJ379_RS16650 ENOG41082W1 Cupin 2, conserved barrel domain protein EJ379_RS16660 ENOG410874W AraC family transcriptional regulator EJ379_RS16680 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EJ379_RS16930 ENOG4108VXD carboxy-peptidase EJ379_RS16935 ENOG4105PNM synthesis protein EJ379_RS16945 ENOG4108ISG Major Facilitator EJ379_RS16960 ENOG4107MII Sugar-specific transcriptional regulator TrmB EJ379_RS16965 ENOG4105CZM Major Facilitator EJ379_RS16975 ENOG4108Z66 YbaK ebsC protein EJ379_RS16980 ENOG4105CUT histidyl-tRNA synthetase EJ379_RS16995 ENOG4105KVH Transcriptional regulator EJ379_RS17000 ENOG4108RCM Nitroreductase EJ379_RS17030 ENOG4108PSK reductase EJ379_RS17105 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EJ379_RS17135 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) EJ379_RS17145 ENOG4105EV4 Multidrug resistance protein mdtH EJ379_RS17175 ENOG4105C37 (CBS) domain EJ379_RS17190 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EJ379_RS17195 ENOG4105FAW cDP-glucose 4,6-dehydratase EJ379_RS17230 ENOG4105DDN Pentapeptide repeat-containing protein EJ379_RS17235 ENOG4105XDF Protein of unknown function (DUF1272) EJ379_RS17240 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EJ379_RS17245 ENOG4105CMG Carbohydrate kinase EJ379_RS17250 ENOG4105C6Z Gluconate EJ379_RS17265 ENOG4105CV1 Transketolase (EC 2.2.1.1) EJ379_RS17270 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EJ379_RS17285 ENOG4105CIS alcohol dehydrogenase EJ379_RS17290 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone EJ379_RS17310 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EJ379_RS17325 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_RS17330 ENOG4108UX3 '-nucleotidase EJ379_RS17335 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EJ379_RS17340 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EJ379_RS17345 ENOG4105KVH Transcriptional regulator EJ379_RS17360 ENOG4105CV8 reductase EJ379_RS17365 ENOG4105F27 Major Facilitator EJ379_RS17375 ENOG41090KN UPF0303 protein EJ379_RS17390 ENOG4105C44 Serine transporter EJ379_RS17420 ENOG4105KVH Transcriptional regulator EJ379_RS17425 ENOG4108TZY GntR Family Transcriptional Regulator EJ379_RS17430 ENOG4105D9R oxidoreductase EJ379_RS17435 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EJ379_RS17440 ENOG4105KVH Transcriptional regulator EJ379_RS17445 ENOG4105KVH Transcriptional regulator EJ379_RS17490 ENOG4105JAB phenazine biosynthesis protein, phzf family EJ379_RS17500 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EJ379_RS17505 ENOG4105KVH Transcriptional regulator EJ379_RS17515 ENOG4108ZJ4 polysaccharide deacetylase EJ379_RS17535 ENOG410829K Lysine exporter protein (Lyse ygga) EJ379_RS17590 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) EJ379_RS17600 ENOG4107YXZ hydrolase, family 25 EJ379_RS17630 ENOG4105H3G oxidoreductase EJ379_RS17700 ENOG4108TN2 lmbE family EJ379_RS17710 ENOG4107R3E Citrate transporter EJ379_RS17720 ENOG4105WCN acetyltransferase EJ379_RS17725 ENOG4108MES Periplasmic binding protein EJ379_RS17730 ENOG4105EHG Permease protein EJ379_RS17735 ENOG4105DQ5 transport system permease protein EJ379_RS17740 ENOG4105NX3 Membrane EJ379_RS17760 ENOG41068WN EJ379_RS17765 ENOG4107CUJ Protein of unknown function (DUF2690) EJ379_RS17775 ENOG4107V2S Transcriptional regulator EJ379_RS17805 ENOG4105E5K Alpha-amylase EJ379_RS17810 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase EJ379_RS17815 ENOG4105DPN Oligoendopeptidase f EJ379_RS17855 ENOG4108A04 Beta-lactamase EJ379_RS17880 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EJ379_RS17890 ENOG41082BM Transcriptional regulator, arsr family EJ379_RS17895 ENOG4105CIS alcohol dehydrogenase EJ379_RS17900 ENOG4105CNG UPF0061 protein EJ379_RS17920 ENOG4105CQB FAD linked oxidase domain protein EJ379_RS17945 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EJ379_RS17955 ENOG4107TPS domain protein EJ379_RS17960 ENOG4105CEP NADH dehydrogenase EJ379_RS17970 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EJ379_RS17980 ENOG4108IAJ Nad-dependent epimerase dehydratase EJ379_RS17985 ENOG4105FAW cDP-glucose 4,6-dehydratase EJ379_RS18020 ENOG41067SE Tetr family transcriptional regulator EJ379_RS18025 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity EJ379_RS18035 ENOG4107DUR UPF0457 protein EJ379_RS18055 ENOG4105BZU Histidine kinase EJ379_RS18065 ENOG4105KT7 mgtC SapB transporter EJ379_RS18075 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EJ379_RS18080 ENOG41073R8 VanW family EJ379_RS18090 ENOG4108R1P EJ379_RS18105 ENOG4105VEQ Cold shock protein EJ379_RS18125 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EJ379_RS18145 ENOG410904N short-chain dehydrogenase reductase EJ379_RS18155 ENOG4106IQC argininosuccinate lyase EJ379_RS18170 ENOG4108IA2 Sodium pantothenate symporter EJ379_RS18180 ENOG4105C26 Dehydrogenase EJ379_RS18185 ENOG4105CHR reductase EJ379_RS18195 ENOG4105EWU Squalene--hopene cyclase EJ379_RS18205 ENOG4105FR1 rard protein EJ379_RS18210 ENOG410696E Membrane EJ379_RS18225 ENOG4105D1F ATP-binding protein EJ379_RS18235 ENOG4108ZAF Molybdopterin EJ379_RS18240 ENOG4105CVM Molybdenum cofactor synthesis domain protein EJ379_RS18245 ENOG4105D06 uba thif-type nad fad binding protein EJ379_RS18250 ENOG4105TMB Formate nitrite transporter EJ379_RS18260 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EJ379_RS18265 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) EJ379_RS18275 ENOG4108JB9 formate dehydrogenase EJ379_RS18280 ENOG4105E1K spore germination protein EJ379_RS18295 ENOG4105CUB amino acid EJ379_RS18350 ENOG4108KGH TRANSCRIPTIONal EJ379_RS18360 ENOG4105EMN RNA polymerase sigma factor EJ379_RS18370 ENOG4105CIG ABC transporter EJ379_RS18390 ENOG4105D9R oxidoreductase EJ379_RS18400 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJ379_RS18405 ENOG4105K4P CoA-binding domain protein EJ379_RS18410 ENOG4105C0H protease EJ379_RS18415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS18425 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase EJ379_RS18435 ENOG4105W8X HesB YadR YfhF-family protein EJ379_RS18465 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EJ379_RS18470 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EJ379_RS18485 ENOG4105BZ1 (ABC) transporter EJ379_RS18490 ENOG4108I0Z Aconitate hydratase EJ379_RS18520 ENOG4105E5W Transporter EJ379_RS18530 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EJ379_RS18550 ENOG4107F3J Amp-dependent synthetase and ligase EJ379_RS18555 ENOG4107ZYJ bioY protein EJ379_RS18560 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_RS18605 ENOG4107AYK membrAne EJ379_RS18620 ENOG4105BZU Histidine kinase EJ379_RS18625 ENOG4105FBA Phospholipase Carboxylesterase EJ379_RS18630 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase EJ379_RS18635 ENOG4105CK7 Sodium proline symporter EJ379_RS18645 ENOG4105CBC glutamate synthase EJ379_RS18650 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJ379_RS18655 ENOG4108VJ1 Transcriptional regulator (CarD family EJ379_RS18660 ENOG4108903 Formimidoylglutamase EJ379_RS18665 ENOG4105CI2 imidazolone-5-propionate hydrolase EJ379_RS18670 ENOG4105CGP Urocanate hydratase EJ379_RS18715 ENOG4107QIV Cytochrome c biogenesis protein EJ379_RS18740 ENOG4105CJ1 ABC, transporter EJ379_RS18755 ENOG4107RSM transcriptional regulator EJ379_RS18765 ENOG41067MG lrgb family EJ379_RS18805 ENOG4105BZ1 (ABC) transporter EJ379_RS18810 ENOG4105BZ1 (ABC) transporter EJ379_RS18845 ENOG4108HW3 (ABC) transporter EJ379_RS18850 ENOG4105CGH 5'-nucleotidase EJ379_RS18860 ENOG4108SVB resolvase EJ379_RS18880 ENOG4105K7K Transcriptional regulator EJ379_RS18885 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EJ379_RS18905 ENOG4105E4C Lytic transglycosylase catalytic EJ379_RS18910 ENOG41065S2 pneumococcal vaccine antigen EJ379_RS18945 ENOG4105C5F glutamine synthetase EJ379_RS18950 ENOG4105KV4 Transcriptional regulator EJ379_RS18955 ENOG4105CXI aluminum resistance protein EJ379_RS18960 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EJ379_RS18965 ENOG4105EN6 Membrane EJ379_RS18970 ENOG4106F1P AAA ATPase, central domain protein EJ379_RS19000 ENOG41069ER domain protein EJ379_RS19005 ENOG4105DM4 PTS System EJ379_RS19010 ENOG4105DE4 1-phosphofructokinase EJ379_RS19015 ENOG4105E98 transcriptional regulator DeoR family EJ379_RS19020 ENOG4107QW4 alcohol dehydrogenase EJ379_RS19025 ENOG4108SJC Membrane EJ379_RS19035 ENOG4105C85 amino acid EJ379_RS19055 ENOG4105TMB Formate nitrite transporter EJ379_RS19060 ENOG4105K70 DNA-binding protein EJ379_RS19070 ENOG4105C59 p-type ATPase EJ379_RS19075 ENOG410681U heavy metal transport detoxification protein EJ379_RS19080 ENOG4105VPX protein, conserved in bacteria EJ379_RS19090 ENOG4105NIV Esterase EJ379_RS19095 ENOG4105E0A ABC, transporter EJ379_RS19115 ENOG4105CGK Exodeoxyribonuclease III EJ379_RS19125 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EJ379_RS19130 ENOG4105D03 DNA-3-methyladenine glycosylase II EJ379_RS19135 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EJ379_RS19155 ENOG4105BZU Histidine kinase EJ379_RS19195 ENOG41067MG lrgb family EJ379_RS19215 ENOG4108S3Y transcriptional regulator EJ379_RS19220 ENOG4105CS2 ec 3.2.1.21 EJ379_RS19235 ENOG4105F0V Cell wall hydrolase EJ379_RS19250 ENOG4105E0M Sulfatase EJ379_RS19255 ENOG410890F Dynamin family EJ379_RS19285 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EJ379_RS19290 ENOG4105DQU oxidoreductase, subunit beta EJ379_RS19295 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein EJ379_RS19300 ENOG4108IGT Dipeptidase EJ379_RS19305 ENOG4105MCT stage V sporulation protein S EJ379_RS19310 ENOG4105D48 metallophosphoesterase EJ379_RS19325 ENOG4105CEV competence damage-inducible protein EJ379_RS19330 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EJ379_RS19345 ENOG4105XZV Protein of unknown function (DUF3243) EJ379_RS19350 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EJ379_RS19370 ENOG4105UIB (ABC) transporter EJ379_RS19375 ENOG4108JQ9 ABC transporter EJ379_RS19380 ENOG4105DIH basic membrane EJ379_RS19385 ENOG4105FDP GntR family transcriptional regulator EJ379_RS19395 ENOG4105CNU cell division protein FtsK EJ379_RS19405 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit EJ379_RS19415 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJ379_RS19425 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EJ379_RS19430 ENOG4108S0H Dipicolinic acid synthetase, b subunit EJ379_RS19435 ENOG4105E35 Dipicolinate synthase subunit A EJ379_RS19445 ENOG4105C1V Peptidase, M16 EJ379_RS19465 ENOG4105DTN riboflavin biosynthesis protein ribF EJ379_RS19480 ENOG4105W7A Protein of unknown function (DUF503) EJ379_RS19490 ENOG4105VHM ribosomal protein EJ379_RS19495 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination EJ379_RS19500 ENOG4105CHV Transcription elongation factor NusA EJ379_RS19510 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EJ379_RS19520 ENOG4105DZP Membrane-associated zinc metalloprotease EJ379_RS19525 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EJ379_RS19530 ENOG4105KNE Phosphatidate cytidylyltransferase EJ379_RS19535 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EJ379_RS19545 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EJ379_RS19575 ENOG4108HE4 integrase family EJ379_RS19580 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) EJ379_RS19585 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EJ379_RS19590 ENOG4105C79 DNA protecting protein DprA EJ379_RS19595 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EJ379_RS19605 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EJ379_RS19610 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EJ379_RS19635 ENOG4105VB6 UPF0109 protein EJ379_RS19655 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EJ379_RS19660 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EJ379_RS19675 ENOG4105CHR reductase EJ379_RS19680 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EJ379_RS19685 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EJ379_RS19695 ENOG4105CB5 ATP-dependent DNA helicase recG EJ379_RS19700 ENOG4105DP4 dak2 domain fusion protein ylov EJ379_RS19705 ENOG4108ZAA Alkaline-shock protein EJ379_RS19720 ENOG4105FJ0 thiamine EJ379_RS19725 ENOG4105DJV ribulose-phosphate 3-epimerase EJ379_RS19730 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EJ379_RS19735 ENOG4105D9P serine threonine protein kinase EJ379_RS19740 ENOG4108ZF3 Phosphatase EJ379_RS19745 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EJ379_RS19750 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EJ379_RS19765 ENOG4105C25 Primosomal protein n' EJ379_RS19770 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EJ379_RS19790 ENOG4105DSJ YicC domain protein EJ379_RS19810 ENOG4105DC7 peptidase M24 EJ379_RS19845 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EJ379_RS19860 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EJ379_RS19865 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EJ379_RS19870 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EJ379_RS19875 ENOG4105CD3 dihydroorotase EJ379_RS19895 ENOG4105C34 Pseudouridine synthase EJ379_RS19920 ENOG4105DBK s4 domain protein EJ379_RS19925 ENOG41067XK integral membrane protein EJ379_RS19935 ENOG4105DFA alanine racemase domain protein EJ379_RS19940 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EJ379_RS19945 ENOG4105WR5 sporulation protein, YlmC YmxH family EJ379_RS19955 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_RS19965 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EJ379_RS19970 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EJ379_RS19980 ENOG4105D4A Cell wall formation (By similarity) EJ379_RS19985 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EJ379_RS19990 ENOG4105CNI cell division protein FtsW EJ379_RS19995 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EJ379_RS20005 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EJ379_RS20010 ENOG4105CJN penicillin-binding protein EJ379_RS20015 ENOG4105CJN penicillin-binding protein EJ379_RS20030 ENOG41074B2 UPF0747 protein EJ379_RS20055 ENOG4105KNH Nucleic acid-binding protein EJ379_RS20065 ENOG41063PX domain protein EJ379_RS20070 ENOG4105D78 K07001 NTE family protein EJ379_RS20075 ENOG4105H20 Sporulation integral membrane protein YlbJ EJ379_RS20085 ENOG4106H78 methyltransferase EJ379_RS20105 ENOG4107TB6 phosphoglycerate mutase EJ379_RS20120 ENOG4106UY4 Inherit from COG: Scp-like extracellular EJ379_RS20165 ENOG4107VFP cytochrome oxidase assembly EJ379_RS20170 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EJ379_RS20180 ENOG4105CNI cell division protein FtsW EJ379_RS20195 ENOG4108IAB Phoh family EJ379_RS20215 ENOG4105QA2 EJ379_RS20220 ENOG4105CI3 gtp-binding protein typa EJ379_RS20230 ENOG4105ECY inositol monophosphatase EJ379_RS20250 ENOG4105CXN decarboxylase EJ379_RS20300 ENOG4105CPP Dehydrogenase, E1 component EJ379_RS20315 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EJ379_RS20320 ENOG4108X4Q Hydrolase EJ379_RS20335 ENOG4105CN5 Metallo-Beta-Lactamase EJ379_RS20340 ENOG4107ZYR domain protein EJ379_RS20350 ENOG4105CH2 amidohydrolase EJ379_RS20375 ENOG4108XRC Protein of unknown function (DUF458) EJ379_RS20380 ENOG4107IN1 Protein of unknown function (DUF1797) EJ379_RS20395 ENOG4105EPM Diguanylate phosphodiesterase EJ379_RS20400 ENOG4105K6S Short-chain dehydrogenase reductase Sdr EJ379_RS20415 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) EJ379_RS20425 ENOG4105UIN EJ379_RS20460 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EJ379_RS20480 ENOG4108HGU Histidine kinase EJ379_RS20490 ENOG4105CHM Aminotransferase EJ379_RS20495 ENOG4105FKQ transcriptional regulator EJ379_RS20500 ENOG4105EG2 ABC transporter, permease EJ379_RS20510 ENOG4107FKK extracellular solute-binding protein family 1 EJ379_RS20520 ENOG4105CG3 alpha amylase, catalytic region EJ379_RS20565 ENOG4105CHU acetyl-coa acetyltransferase EJ379_RS20600 ENOG4105K7K Transcriptional regulator EJ379_RS20605 ENOG4105DTD Dehydrogenase EJ379_RS20620 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) EJ379_RS20625 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EJ379_RS20635 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate EJ379_RS20650 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EJ379_RS20665 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EJ379_RS20675 ENOG4105BZU Histidine kinase EJ379_RS20695 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EJ379_RS20710 ENOG4105CID antiterminator EJ379_RS20730 ENOG4105CE4 GlcNAc 6-P deacetylase EJ379_RS20770 ENOG4107ZE5 PPIases accelerate the folding of proteins EJ379_RS20775 ENOG4105PTM secreted protein EJ379_RS20780 ENOG4105J7I hydrolase EJ379_RS20790 ENOG4105G6R Stage v sporulation protein ae EJ379_RS20800 ENOG4105CZ3 stage V sporulation protein ad EJ379_RS20805 ENOG41090VF Stage v sporulation protein ac EJ379_RS20825 ENOG4105C8J )-transporter EJ379_RS20830 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_RS20840 ENOG41082AN stage II sporulation protein EJ379_RS20845 ENOG4105DZ1 carboxypeptidase EJ379_RS20855 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJ379_RS20860 ENOG4105DVE abc transporter atp-binding protein EJ379_RS20895 ENOG4105D7N magnesium and cobalt transport protein CorA EJ379_RS20920 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EJ379_RS20930 ENOG4105I3K Ferric uptake regulator, Fur family EJ379_RS20935 ENOG4105MZ9 stage II sporulation protein m EJ379_RS20955 ENOG4105CPC Aldo Keto reductase EJ379_RS20965 ENOG4105RHY Pfam:UPF0157 EJ379_RS20985 ENOG4107SKW Inherit from COG: Alpha beta hydrolase EJ379_RS20995 ENOG4105ETE Transcriptional regulator (LacI family EJ379_RS21000 ENOG4108YM7 Gcn5-related n-acetyltransferase EJ379_RS21020 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EJ379_RS21025 ENOG4108R6K riboflavin synthase, subunit alpha EJ379_RS21030 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EJ379_RS21050 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJ379_RS21055 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJ379_RS21065 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EJ379_RS21070 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJ379_RS21085 ENOG4105DFD Na H antiporter EJ379_RS21090 ENOG4105CGH 5'-nucleotidase EJ379_RS21115 ENOG4105DBV ornithine carbamoyltransferase EJ379_RS21130 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EJ379_RS21145 ENOG4108IXY short-chain dehydrogenase reductase EJ379_RS21150 ENOG41069FQ Metallo-beta-lactamase superfamily EJ379_RS21155 ENOG4105II7 pyrroline-5-carboxylate reductase EJ379_RS21160 ENOG4105EJQ L-serine dehydratase EJ379_RS21175 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EJ379_RS21190 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EJ379_RS21205 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EJ379_RS21210 ENOG4105D9U N-acetyltransferase EJ379_RS21220 ENOG4108VZI ErfK ybiS ycfS ynhG family protein EJ379_RS21225 ENOG4108QEG Membrane EJ379_RS21230 ENOG4105CDA abc transporter atp-binding protein EJ379_RS21235 ENOG4105E5Q amino acid AbC transporter EJ379_RS21240 ENOG4108HW3 (ABC) transporter EJ379_RS21250 ENOG4105G7B Protein of unknown function (DUF2992) EJ379_RS21255 ENOG4105E09 nadh pyrophosphatase EJ379_RS21260 ENOG4108QY0 Membrane EJ379_RS21270 ENOG4105C7S Dehydrogenase EJ379_RS21275 ENOG4105CPP Dehydrogenase, E1 component EJ379_RS21290 ENOG4105CKM Branched-chain carboxylic acid kinase EJ379_RS21295 ENOG4107RDP Dehydrogenase EJ379_RS21310 ENOG4108JUB Transcriptional regulator EJ379_RS21320 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJ379_RS21335 ENOG4107QQR Sporulation EJ379_RS21345 ENOG4105S1Z Stage IV sporulation protein B EJ379_RS21350 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EJ379_RS21355 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EJ379_RS21360 ENOG4105DX0 Hemolysin A EJ379_RS21370 ENOG4105CTB Polyprenyl synthetase EJ379_RS21385 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EJ379_RS21395 ENOG4108ZSR alkaline shock protein EJ379_RS21400 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EJ379_RS21425 ENOG410644B Stage III sporulation protein af EJ379_RS21435 ENOG4105KQ4 Stage iii sporulation protein ad EJ379_RS21440 ENOG4108CQH stage III sporulation protein AC EJ379_RS21445 ENOG4105KR5 Stage iii sporulation protein EJ379_RS21450 ENOG4105CD2 stage iii sporulation protein aa EJ379_RS21475 ENOG4105DC7 peptidase M24 EJ379_RS21480 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EJ379_RS21490 ENOG4105CBJ Metal-dependent enzyme EJ379_RS21500 ENOG4107YBY Hydrolase EJ379_RS21530 ENOG41082GG biotin lipoate A B protein ligase EJ379_RS21535 ENOG4105WZW rhodanese family EJ379_RS21560 ENOG41080TC multidrug resistance protein EJ379_RS21595 ENOG4105CJ1 ABC, transporter EJ379_RS21600 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJ379_RS21615 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EJ379_RS21635 ENOG4105C0D helicase EJ379_RS21720 ENOG4107R6U sodium dicarboxylate symporter EJ379_RS21755 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EJ379_RS21760 ENOG4105C3R Methionine synthase EJ379_RS21770 ENOG4105C28 cystathionine EJ379_RS21775 ENOG4105C28 cystathionine EJ379_RS21795 ENOG4105C5X domain protein EJ379_RS21805 ENOG4105DKQ ROK family EJ379_RS21815 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EJ379_RS21835 ENOG4108UTW Plays a role in the regulation of phosphate uptake EJ379_RS21840 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EJ379_RS21845 ENOG4105C8U phosphate abc transporter EJ379_RS21850 ENOG4105C8U phosphate abc transporter EJ379_RS21855 ENOG4105EXS phosphate abc transporter EJ379_RS21860 ENOG4107RF6 penicillin-binding protein EJ379_RS21870 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EJ379_RS21895 ENOG4105N80 Ferric uptake regulator, Fur family EJ379_RS21905 ENOG4105FDK ABC transporter EJ379_RS21910 ENOG4108JYZ YitT family EJ379_RS21915 ENOG41069ZM Protein of unknown function (DUF2624) EJ379_RS21940 ENOG4105EGD dinuclear metal center protein, YbgI family EJ379_RS21955 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_RS21960 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EJ379_RS21965 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EJ379_RS21985 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EJ379_RS21990 ENOG4105KG3 cytidine deaminase EJ379_RS21995 ENOG4107YR5 Diacylglycerol kinase EJ379_RS22000 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EJ379_RS22005 ENOG4105CTJ Metal Dependent Phosphohydrolase EJ379_RS22010 ENOG4105C9A Phoh family EJ379_RS22020 ENOG41068P3 sporulation protein YqfC EJ379_RS22030 ENOG4105KTH gatB Yqey EJ379_RS22040 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EJ379_RS22045 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EJ379_RS22075 ENOG4105CSA Coproporphyrinogen iii oxidase EJ379_RS22080 ENOG4105KVH Transcriptional regulator EJ379_RS22105 ENOG4105TQK DNA polymerase iii, delta' subunit EJ379_RS22115 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EJ379_RS22120 ENOG4108UK2 deaminase EJ379_RS22125 ENOG4105KQC Competence protein EJ379_RS22135 ENOG4105DXX methyltransferase EJ379_RS22145 ENOG4108WF2 Metal Dependent Phosphohydrolase EJ379_RS22155 ENOG410812S Rna-binding protein EJ379_RS22165 ENOG4105CQW ribosome biogenesis GTPase YqeH EJ379_RS22170 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EJ379_RS22185 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_RS22205 ENOG4108TVJ Nitroreductase EJ379_RS22220 ENOG4105G6Z alkaline phosphatase EJ379_RS22225 ENOG4105KEG ribosomal-protein-alanine acetyltransferase EJ379_RS22230 ENOG4108MUZ hydrolase EJ379_RS22270 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ379_RS22275 ENOG4105MIR Phenylalanine 4-monooxygenase EJ379_RS22285 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EJ379_RS22325 ENOG4105S6R Iron-hydroxamate transporter permease subunit EJ379_RS22330 ENOG4108HUF Transporter EJ379_RS22345 ENOG4105C0A alcohol dehydrogenase EJ379_RS22350 ENOG4105C28 cystathionine EJ379_RS22380 ENOG4107XRG penicillin-binding protein EJ379_RS22390 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EJ379_RS22400 ENOG4105CFP Peptidase U32 EJ379_RS22405 ENOG4105XYU peptidase (U32 family) EJ379_RS22415 ENOG4105HHA aminodeoxychorismate lyase EJ379_RS22435 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EJ379_RS22445 ENOG4105C02 permease EJ379_RS22460 ENOG41060CR EJ379_RS22465 ENOG4105C7H Helicase, RecD TraA family EJ379_RS22475 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EJ379_RS22480 ENOG4105C3J Cysteine desulfurase EJ379_RS22490 ENOG4105D1H recombination factor protein RarA EJ379_RS22495 ENOG4108VCI transcription factor, rsfa family EJ379_RS22505 ENOG4105CUZ uba thif-type nad fad binding protein EJ379_RS22515 ENOG4105CUT histidyl-tRNA synthetase EJ379_RS22520 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EJ379_RS22525 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EJ379_RS22535 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EJ379_RS22540 ENOG41076HS cation diffusion facilitator family transporter EJ379_RS22545 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EJ379_RS22555 ENOG4105CKP Polysaccharide Biosynthesis Protein EJ379_RS22560 ENOG4108QG2 Membrane EJ379_RS22570 ENOG4105VIE preprotein translocase, subunit YajC EJ379_RS22580 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EJ379_RS22585 ENOG41061AI Protein of unknown function (DUF2905) EJ379_RS22600 ENOG4108HUF Transporter EJ379_RS22625 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EJ379_RS22630 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EJ379_RS22635 ENOG4108IYU L-aspartate oxidase EJ379_RS22650 ENOG4108RPX mosc domain containing protein EJ379_RS22655 ENOG4105CQC Prephenate dehydratase EJ379_RS22670 ENOG4105C19 ABC transporter EJ379_RS22675 ENOG4105EWM Histidine kinase EJ379_RS22685 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EJ379_RS22705 ENOG4105C03 ribonuclease EJ379_RS22720 ENOG4107QMS site-determining protein EJ379_RS22740 ENOG4105DFF Rod shape-determining protein mreb EJ379_RS22785 ENOG4105DZR Type I site-specific deoxyribonuclease EJ379_RS22815 ENOG4108Z03 MAF-like protein EJ379_RS22825 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EJ379_RS22830 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EJ379_RS22840 ENOG41068KH stage VI sporulation protein D EJ379_RS22850 ENOG4105D52 delta-aminolevulinic acid dehydratase EJ379_RS22875 ENOG4105K56 Transcriptional regulator EJ379_RS22895 ENOG4108IUQ atp-dependent protease EJ379_RS22920 ENOG4108QCI YvbH-like oligomerisation region EJ379_RS22935 ENOG4105C4R Atp-dependent dna helicase EJ379_RS22960 ENOG4105M59 Phosphodiesterase, mj0936 family EJ379_RS22965 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EJ379_RS22975 ENOG4108XJQ germination protein EJ379_RS22985 ENOG4108PCX Major Facilitator EJ379_RS22995 ENOG4105KBX Transcriptional regulator, TetR family EJ379_RS23005 ENOG4105PFC Transcriptional regulator EJ379_RS23015 ENOG4105DZC cytosine deaminase EJ379_RS23020 ENOG41067S9 phage shock protein C, PspC EJ379_RS23025 ENOG4108JCI Transcriptional regulator EJ379_RS23035 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EJ379_RS23040 ENOG4108Z40 Transcriptional regulator EJ379_RS23045 ENOG4105RHA ABC transporter, permease EJ379_RS23050 ENOG4108IUX (ABC) transporter EJ379_RS23055 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family EJ379_RS23060 ENOG4105ER2 Ompa motb domain protein EJ379_RS23065 ENOG4105E14 MotA TolQ exbB proton channel EJ379_RS23070 ENOG4108VXD carboxy-peptidase EJ379_RS23080 ENOG4105E33 succinate dehydrogenase EJ379_RS23090 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit EJ379_RS23100 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EJ379_RS23105 ENOG4105K63 Thioredoxin EJ379_RS23110 ENOG4105C10 Electron transfer flavoprotein EJ379_RS23115 ENOG4105BZJ Electron transfer flavoprotein EJ379_RS23120 ENOG41060WC Enoyl-CoA hydratase EJ379_RS23125 ENOG4107Z3H Transcriptional regulator, TetR family EJ379_RS23130 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_RS23140 ENOG4105J76 Periplasmic binding protein EJ379_RS23145 ENOG4105S6R Iron-hydroxamate transporter permease subunit EJ379_RS23190 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJ379_RS23200 ENOG4105DR4 Methyltransferase EJ379_RS23210 ENOG4105KFN sortase, SrtB family EJ379_RS23215 ENOG4105E0A ABC, transporter EJ379_RS23230 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) EJ379_RS23240 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) EJ379_RS23250 ENOG4105FE9 pseudouridine synthase EJ379_RS23260 ENOG4105DCG PHP domain protein EJ379_RS23275 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EJ379_RS23295 ENOG4105C5S asparaginyl-tRNA synthetase EJ379_RS23300 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EJ379_RS23310 ENOG4108RWN rrna methyltransferase EJ379_RS23340 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJ379_RS23345 ENOG4105CW7 secretion protein, HlyD family EJ379_RS23350 ENOG4108JGH Tetr family transcriptional regulator EJ379_RS23355 ENOG4105CN9 Peptidase m42 family protein EJ379_RS23375 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EJ379_RS23380 ENOG4105C22 threonyL-tRNA synthetase EJ379_RS23385 ENOG4108TDW sporulation protein YtxC EJ379_RS23415 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EJ379_RS23420 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EJ379_RS23430 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EJ379_RS23435 ENOG4105C2M dna polymerase I EJ379_RS23440 ENOG4105BZU Histidine kinase EJ379_RS23445 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJ379_RS23460 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EJ379_RS23465 ENOG4108HMX isocitrate dehydrogenase (NADP) EJ379_RS23470 ENOG4105BZN citrate synthase EJ379_RS23485 ENOG4108REF Sporulation integral membrane protein ytvi EJ379_RS23490 ENOG4105FS0 cytoplasmic membrane protein EJ379_RS23515 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family EJ379_RS23520 ENOG4105C6K Malic enzyme EJ379_RS23525 ENOG4105C0B DNA polymerase III (alpha subunit) EJ379_RS23530 ENOG4105VV2 EJ379_RS23540 ENOG4105SFS phosphoesterase RecJ domain protein EJ379_RS23560 ENOG4105E8R UPF0173 metal-dependent hydrolase EJ379_RS23565 ENOG4105DC7 peptidase M24 EJ379_RS23600 ENOG4105Z7P Acetyltransferase (GNAT) family EJ379_RS23605 ENOG41082W1 Cupin 2, conserved barrel domain protein EJ379_RS23625 ENOG4107YZX Universal stress protein EJ379_RS23645 ENOG4105CH7 arginosuccinase EJ379_RS23665 ENOG4108JYZ YitT family EJ379_RS23685 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EJ379_RS23695 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EJ379_RS23700 ENOG4105KBJ sporulation protein ytfj EJ379_RS23715 ENOG4105EFZ amidohydrolase EJ379_RS23725 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJ379_RS23735 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EJ379_RS23750 ENOG4105RQF LysR family Transcriptional regulator EJ379_RS23760 ENOG4105U5Y Transcriptional regulator EJ379_RS23770 ENOG4105C28 cystathionine EJ379_RS23790 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EJ379_RS23795 ENOG4108UW5 maltose o-acetyltransferase EJ379_RS23805 ENOG4105F1V Acetoin utilization protein EJ379_RS23810 ENOG4105W87 Cbs domain EJ379_RS23815 ENOG4105DGU Histone deacetylase EJ379_RS23830 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJ379_RS23840 ENOG4107SNB ankyrin repeat protein YahD EJ379_RS23845 ENOG4105EP9 oxidoreductase EJ379_RS23865 ENOG4105ETE Transcriptional regulator (LacI family EJ379_RS23870 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EJ379_RS23890 ENOG4105C88 aminopeptidase EJ379_RS23935 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EJ379_RS23945 ENOG4108VDD TRNA binding domain protein EJ379_RS23975 ENOG4105C8F Beta-lactamase domain protein EJ379_RS23990 ENOG4108V15 phosphotransferase enzyme family EJ379_RS23995 ENOG4108IUM Glycogen debranching enzyme EJ379_RS24005 ENOG4107QSE Dipeptidase EJ379_RS24010 ENOG4105YW5 deoR family transcriptional regulator EJ379_RS24025 ENOG4105CBX hi0933 family EJ379_RS24060 ENOG4108VJ1 Transcriptional regulator (CarD family EJ379_RS24065 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EJ379_RS24070 ENOG4105CSC Glucose uptake protein EJ379_RS24085 ENOG4108ZAF Molybdopterin EJ379_RS24090 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein EJ379_RS24095 ENOG4105CVM Molybdenum cofactor synthesis domain protein EJ379_RS24105 ENOG4105D06 uba thif-type nad fad binding protein EJ379_RS24110 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJ379_RS24135 ENOG41085GJ domain protein EJ379_RS24145 ENOG4105DWV Homoserine O-trans-acetylase EJ379_RS24155 ENOG4108B31 Spore germination protein EJ379_RS24180 ENOG4105C8T Leucyl-tRNA synthetase EJ379_RS24185 ENOG410605W Major Facilitator EJ379_RS24190 ENOG4107S91 Sodium hydrogen exchanger EJ379_RS24195 ENOG4105NCW Trka-c domain protein EJ379_RS24215 ENOG4105C19 ABC transporter EJ379_RS24235 ENOG4105N5T Radical SAM Protein EJ379_RS24250 ENOG4105CIG ABC transporter EJ379_RS24280 ENOG4105E8V Alpha Beta Hydrolase Fold protein EJ379_RS24285 ENOG4108Z0R Transferase EJ379_RS24290 ENOG4105YVM Phosphoesterase, PA-phosphatase related EJ379_RS24295 ENOG4105BZF Glycosyl transferase (Group 1 EJ379_RS24305 ENOG4105EPU Molybdenum cofactor synthesis domain protein EJ379_RS24315 ENOG4108MK9 spermidine N(1)-acetyltransferase EJ379_RS24365 ENOG4105BZU Histidine kinase EJ379_RS24370 ENOG4105BZU Histidine kinase EJ379_RS24375 ENOG4105CH6 catalase EJ379_RS24385 ENOG4107S9D Alpha beta hydrolase EJ379_RS24390 ENOG4107T7U Sulfatase EJ379_RS24405 ENOG4105D2X ABC transporter substrate-binding protein EJ379_RS24415 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EJ379_RS24480 ENOG4108V2W Carbonate dehydratase EJ379_RS24485 ENOG4105C4M (Ubiquinol oxidase) subunit I EJ379_RS24490 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EJ379_RS24530 ENOG41087YS Phage shock protein A EJ379_RS24570 ENOG4105BZU Histidine kinase EJ379_RS24575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS24600 ENOG4108UGV hypoxanthine phosphoribosyltransferase EJ379_RS24605 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) EJ379_RS24650 ENOG4105C19 ABC transporter EJ379_RS24665 ENOG4107ZTW SNARE associated Golgi EJ379_RS24670 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EJ379_RS24680 ENOG4105C19 ABC transporter EJ379_RS24685 ENOG41086D8 Transcriptional regulator EJ379_RS24695 ENOG41082BM Transcriptional regulator, arsr family EJ379_RS24735 ENOG4105C6Z Gluconate EJ379_RS24760 ENOG41069H0 dihydroorotase EC 3.5.2.3 EJ379_RS24785 ENOG4105DTQ mandelate racemase muconate lactonizing EJ379_RS24790 ENOG4105CEY Amp-dependent synthetase and ligase EJ379_RS24795 ENOG4108IPT Naphthoate synthase EJ379_RS24800 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EJ379_RS24805 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) EJ379_RS24810 ENOG4105E4F Isochorismate synthase EJ379_RS24815 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EJ379_RS24825 ENOG4105VEQ Cold shock protein EJ379_RS24845 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) EJ379_RS24855 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) EJ379_RS24860 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) EJ379_RS24870 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin EJ379_RS24975 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EJ379_RS25010 ENOG4105KT7 mgtC SapB transporter EJ379_RS25015 ENOG4107PBV potassium channel EJ379_RS25035 ENOG4105WG9 Conserved Protein EJ379_RS25045 ENOG4105CHM Aminotransferase EJ379_RS25050 ENOG4108ZB6 transcriptional regulator AsnC family EJ379_RS25055 ENOG4105C5I Dehydrogenase EJ379_RS25060 ENOG4108MUZ hydrolase EJ379_RS25070 ENOG4105C87 Aminotransferase class I and II EJ379_RS25080 ENOG4105Y38 Kinase-associated protein B EJ379_RS25090 ENOG4107R3E Citrate transporter EJ379_RS25110 ENOG4105KA0 thioesterase Superfamily protein EJ379_RS25125 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EJ379_RS25140 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EJ379_RS25145 ENOG41069ER domain protein EJ379_RS25160 ENOG4105CEP NADH dehydrogenase EJ379_RS25190 ENOG4105EWC Purine nucleoside phosphorylase EJ379_RS25215 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EJ379_RS25220 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EJ379_RS25240 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EJ379_RS25245 ENOG4105C4B ABC transporter, permease EJ379_RS25250 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EJ379_RS25300 ENOG41083MR nifu domain-containing protein EJ379_RS25315 ENOG4108W5N phosphatidylglycerophosphatase a EJ379_RS25325 ENOG4105DYS nad(p)h dehydrogenase (quinone) EJ379_RS25330 ENOG4105D4U had-superfamily hydrolase, subfamily iia EJ379_RS25345 ENOG4105CBT Fructose-1,6-bisphosphatase EJ379_RS25365 ENOG4105MMD transcriptional regulator EJ379_RS25370 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) EJ379_RS25375 ENOG4107TXC Transcriptional regulator EJ379_RS25380 ENOG41090T1 Membrane EJ379_RS25405 ENOG4105FAA peptidase M23 EJ379_RS25410 ENOG4108YTE sporulation protein YunB EJ379_RS25415 ENOG4105KZD Domain of unknown function (DUF1805) EJ379_RS25420 ENOG4107R8B 5'-nucleotidase EJ379_RS25430 ENOG4105DIW FeS assembly protein SUFB EJ379_RS25435 ENOG4108UNV SUF system FeS assembly protein, NifU family EJ379_RS25440 ENOG4105C9B Cysteine desulfurase EJ379_RS25445 ENOG4105JRK feS assembly protein SufD EJ379_RS25450 ENOG4105C3K feS assembly ATPase SufC EJ379_RS25455 ENOG4105D01 (LipO)protein EJ379_RS25460 ENOG4105D01 (LipO)protein EJ379_RS25465 ENOG4108UMI ABC transporter, permease EJ379_RS25470 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EJ379_RS25495 ENOG41080E8 Transcriptional regulator, Spx MgsR family EJ379_RS25515 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EJ379_RS25540 ENOG4108W8B Beta-lactamase domain protein EJ379_RS25545 ENOG4105C1G acyl-Coa dehydrogenase EJ379_RS25550 ENOG4105CHU acetyl-coa acetyltransferase EJ379_RS25565 ENOG4105DZ1 carboxypeptidase EJ379_RS25585 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EJ379_RS25595 ENOG4108SUT Major Facilitator Superfamily EJ379_RS25600 ENOG4107R7I amino acid EJ379_RS25615 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EJ379_RS25625 ENOG4107AYK membrAne EJ379_RS25665 ENOG4107ZTW SNARE associated Golgi EJ379_RS25675 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EJ379_RS25680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS25685 ENOG4105BZU Histidine kinase EJ379_RS25700 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EJ379_RS25715 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_RS25720 ENOG4105VG1 fes assembly suf system protein EJ379_RS25725 ENOG4105D4Y metalloprotease EJ379_RS25745 ENOG4107T5V SNARE associated Golgi EJ379_RS25750 ENOG4107S91 Sodium hydrogen exchanger EJ379_RS25755 ENOG4105NCW Trka-c domain protein EJ379_RS25775 ENOG4108RMU ferritin dps family protein EJ379_RS25790 ENOG4108URH decarboxylase EJ379_RS25800 ENOG41090A1 ferritin EJ379_RS25810 ENOG4105D9N nucleoside EJ379_RS25815 ENOG4105D9N nucleoside EJ379_RS25830 ENOG4108RYK Nad-dependent epimerase dehydratase EJ379_RS25845 ENOG4105CV8 reductase EJ379_RS25850 ENOG4105F27 Major Facilitator EJ379_RS25855 ENOG4105KVH Transcriptional regulator EJ379_RS25870 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EJ379_RS25875 ENOG4105D4A Cell wall formation (By similarity) EJ379_RS25885 ENOG4105C8Q Methyl-accepting chemotaxis EJ379_RS25895 ENOG4105WMR Protein CrcB homolog EJ379_RS25900 ENOG4105WMR Protein CrcB homolog EJ379_RS25920 ENOG4105C5H ABC transporter EJ379_RS25925 ENOG4108MK9 spermidine N(1)-acetyltransferase EJ379_RS25935 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EJ379_RS25940 ENOG4105EMU Dehydrogenase EJ379_RS25950 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EJ379_RS25955 ENOG4108R85 Short chain dehydrogenase EJ379_RS26060 ENOG4108IPW abc transporter atp-binding protein EJ379_RS26065 ENOG4105CM4 permease protein EJ379_RS26080 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS26210 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EJ379_RS26220 ENOG4105XZU Preprotein translocase, subunit SecG EJ379_RS26225 ENOG41067MG lrgb family EJ379_RS26275 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_RS26295 ENOG41090VF Stage v sporulation protein ac EJ379_RS26300 ENOG4105CZ3 stage V sporulation protein ad EJ379_RS26315 ENOG4108QY0 Membrane EJ379_RS26325 ENOG4105KRI phosphocarrier protein (HPr EJ379_RS26335 ENOG4105CHW UPF0052 protein EJ379_RS26345 ENOG4108Z4K mutator MutT protein EJ379_RS26355 ENOG4105C3M thioredoxin reductase EJ379_RS26365 ENOG4108S4C acetyltransferase EJ379_RS26375 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EJ379_RS26385 ENOG41086DT Membrane protein of unknown function EJ379_RS26395 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EJ379_RS26415 ENOG4107TXC Transcriptional regulator EJ379_RS26430 ENOG4105HMI Membrane EJ379_RS26435 ENOG4105DUM transcriptional regulator, lysR family EJ379_RS26445 ENOG4108WS4 fmn reductase EJ379_RS26465 ENOG4105BZ1 (ABC) transporter EJ379_RS26475 ENOG4105CN1 protease EJ379_RS26480 ENOG4105CRP Part of the ABC transporter FtsEX involved in EJ379_RS26485 ENOG4105CAK Cell division ATP-binding protein ftsE EJ379_RS26510 ENOG4105MS2 ribosomal subunit Interface protein EJ379_RS26515 ENOG4105VEQ Cold shock protein EJ379_RS26520 ENOG41081UC Inherit from COG: Competence protein EJ379_RS26550 ENOG4105KVH Transcriptional regulator EJ379_RS26560 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EJ379_RS26565 ENOG4108KGH TRANSCRIPTIONal EJ379_RS26570 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EJ379_RS26575 ENOG4105C6Y Udp-glucose 6-dehydrogenase EJ379_RS26580 ENOG4105ESV Glycosyl transferase, family 4 EJ379_RS26590 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EJ379_RS26610 ENOG4105F8D glycoside hydrolase family 4 EJ379_RS26615 ENOG4105VCP PTS System EJ379_RS26620 ENOG4105CK1 PTS System EJ379_RS26630 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EJ379_RS26635 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) EJ379_RS26640 ENOG4105VCP PTS System EJ379_RS26650 ENOG4105VZJ PTS System EJ379_RS26670 ENOG4105ECB domain protein EJ379_RS26675 ENOG4107RSM transcriptional regulator EJ379_RS26700 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EJ379_RS26705 ENOG4105DAA L-lactate EJ379_RS26715 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) EJ379_RS26730 ENOG4105E0M Sulfatase EJ379_RS26755 ENOG4107R8N Glycosyl transferase, family 2 EJ379_RS26760 ENOG4105C94 Transporter EJ379_RS26770 ENOG41069ER domain protein EJ379_RS26795 ENOG4105KBK Zinc finger, swim domain protein EJ379_RS26800 ENOG4105C0D helicase EJ379_RS26830 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJ379_RS26845 ENOG4107RBB ABC transporter, permease EJ379_RS26850 ENOG4105C19 ABC transporter EJ379_RS26870 ENOG4105CXY transporter EJ379_RS26885 ENOG4105BZU Histidine kinase EJ379_RS26890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS26895 ENOG4105CMR udp-glucose 4-epimerase EJ379_RS26905 ENOG4108KGH TRANSCRIPTIONal EJ379_RS26925 ENOG4107T8Q Glycosyl transferase (Group 1 EJ379_RS26935 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) EJ379_RS26940 ENOG4105CPF Cell wall formation (By similarity) EJ379_RS26945 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EJ379_RS26955 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EJ379_RS26960 ENOG4108RB3 Capsular polysaccharide biosynthesis protein EJ379_RS26965 ENOG4107YJ4 chain length determinant protein EJ379_RS26970 ENOG4105HTX biosynthesis protein EJ379_RS26975 ENOG4107YJ4 chain length determinant protein EJ379_RS26990 ENOG4105MT0 Sporulation transcriptional regulator spoiiid EJ379_RS27000 ENOG4105FRN stage II sporulation protein EJ379_RS27015 ENOG4105DY9 regulatoR EJ379_RS27035 ENOG4106778 Protein of unknown function (DUF1146) EJ379_RS27040 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ379_RS27045 ENOG4105C8S subunit m EJ379_RS27050 ENOG4105D65 subunit l EJ379_RS27075 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJ379_RS27080 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJ379_RS27090 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJ379_RS27095 ENOG4105BZU Histidine kinase EJ379_RS27145 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) EJ379_RS27150 ENOG41062M3 atp synthase EJ379_RS27170 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EJ379_RS27175 ENOG4108UIC UPF0340 protein EJ379_RS27180 ENOG4108YZG isomerase EJ379_RS27195 ENOG4108VGI doxx family EJ379_RS27200 ENOG4107XC4 flavin reductase domain protein, FMN-binding EJ379_RS27215 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EJ379_RS27225 ENOG4108ZXQ stage ii sporulation protein r EJ379_RS27230 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EJ379_RS27235 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EJ379_RS27240 ENOG4107104 thymidine kinase EJ379_RS27250 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EJ379_RS27260 ENOG4105CBT Fructose-1,6-bisphosphatase EJ379_RS27265 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EJ379_RS27285 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EJ379_RS27300 ENOG4105C1G acyl-Coa dehydrogenase EJ379_RS27305 ENOG4105C1G acyl-Coa dehydrogenase EJ379_RS27310 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJ379_RS27320 ENOG4105DF6 Fe-S oxidoreductase EJ379_RS27335 ENOG4105BZU Histidine kinase EJ379_RS27350 ENOG4105D4Y metalloprotease EJ379_RS27360 ENOG4105BZU Histidine kinase EJ379_RS27365 ENOG4105KCT ABC transporter EJ379_RS27370 ENOG4108M15 ABC transporter EJ379_RS27375 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) EJ379_RS27385 ENOG4105IIU Aminopeptidase EJ379_RS27405 ENOG4105DU6 RNA polymerase EJ379_RS27415 ENOG410684U Domain of unknown function (DUF1934) EJ379_RS27435 ENOG4105CYW agmatinase EJ379_RS27440 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EJ379_RS27445 ENOG4105DXB Major Facilitator superfamily EJ379_RS27450 ENOG4107SWG transcriptional regulator MERR family EJ379_RS27455 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJ379_RS27460 ENOG4105BZ4 penicillin-binding protein EJ379_RS27465 ENOG4108XFG YwhD family EJ379_RS27470 ENOG4108Z4T Peptidase M50 EJ379_RS27475 ENOG41069HH 4-oxalocrotonate tautomerase EJ379_RS27480 ENOG4105DCI Phosphohydrolase EJ379_RS27485 ENOG4108MES Periplasmic binding protein EJ379_RS27490 ENOG4105E0A ABC, transporter EJ379_RS27495 ENOG4105EHG Permease protein EJ379_RS27500 ENOG4105DQ5 transport system permease protein EJ379_RS27510 ENOG4108VCI transcription factor, rsfa family EJ379_RS27515 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) EJ379_RS27520 ENOG4108IJ2 phosphate acetyltransferase EJ379_RS27535 ENOG4108VKI Cell wall hydrolase EJ379_RS27555 ENOG4107SVH Potassium channel protein EJ379_RS27565 ENOG410667J hydrolase EJ379_RS27570 ENOG4105VCH membrane EJ379_RS27580 ENOG4108TU7 Inherit from COG: (ABC) transporter EJ379_RS27585 ENOG4105CJ1 ABC, transporter EJ379_RS27590 ENOG41090WU lipolytic protein G-D-S-L family EJ379_RS27605 ENOG4105D6E homoserine dehydrogenase EJ379_RS27610 ENOG4105CVG Homoserine O-transsuccinylase EJ379_RS27630 ENOG4108Y4K DNA-binding transcriptional activator EJ379_RS27640 ENOG4105WH1 Two component transcriptional regulator luxr family EJ379_RS27645 ENOG4105BZU Histidine kinase EJ379_RS27650 ENOG4105DWF phosphomethylpyrimidine kinase EJ379_RS27655 ENOG4105BZU Histidine kinase EJ379_RS27660 ENOG4105VCD cytoplasmic protein EJ379_RS27665 ENOG4105D22 carbon starvation protein EJ379_RS27670 ENOG4105DY9 regulatoR EJ379_RS27675 ENOG41079KZ Major Facilitator Superfamily EJ379_RS27690 ENOG4105CG5 Glycosyl transferase (Group 1 EJ379_RS27700 ENOG4105EN6 Membrane EJ379_RS27705 ENOG4106YBV Methyl-accepting chemotaxis EJ379_RS27715 ENOG4108S4H thioesterase Superfamily protein EJ379_RS27720 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) EJ379_RS27735 ENOG4105K64 Glycosyl transferase, family 2 EJ379_RS27750 ENOG4105CKK Glycosyl transferase, family 2 EJ379_RS27755 ENOG4105C5H ABC transporter EJ379_RS27760 ENOG41067SE Tetr family transcriptional regulator EJ379_RS27770 ENOG4105E0X reductase EJ379_RS27775 ENOG4106F5Q Membrane EJ379_RS27785 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) EJ379_RS27790 ENOG4108NEV two component transcriptional regulator, LytTR family EJ379_RS27800 ENOG4107RGD Major Facilitator superfamily EJ379_RS27820 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EJ379_RS27830 ENOG4105IW1 AmiS UreI transporter EJ379_RS27840 ENOG4105CMR udp-glucose 4-epimerase EJ379_RS27845 ENOG4108UT2 hemolysin iii EJ379_RS27855 ENOG4105C1J atp-dependent rna helicase EJ379_RS27860 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) EJ379_RS27865 ENOG4105DPN Oligoendopeptidase f EJ379_RS27875 ENOG4105BZU Histidine kinase EJ379_RS27880 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EJ379_RS27890 ENOG4105C0H protease EJ379_RS27895 ENOG4105Q2H domain protein EJ379_RS27910 ENOG4105BZU Histidine kinase EJ379_RS27915 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJ379_RS27940 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EJ379_RS27945 ENOG4105CDU Replicative dna helicase EJ379_RS27955 ENOG4105BZR domain protein EJ379_RS27960 ENOG4108XMW Membrane EJ379_RS27970 ENOG4108UUM single-stranded DNA-binding protein EJ379_RS27980 ENOG4105C3G gtp-binding protein EJ379_RS27985 ENOG4105VDK protein, conserved in bacteria EJ379_RS27990 ENOG4105D8X mechanosensitive ion channel EJ379_RS27995 ENOG4108ZDA Sporulation protein YyaC EJ379_RS28000 ENOG4105FA0 parb-like partition protein EJ379_RS28005 ENOG4107QJE Chromosome Partitioning Protein EJ379_RS28020 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EJ379_RS28025 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EJ379_RS28035 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EJ379_RS28075 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)