locus-tag	class	description
LW858_RS00005	COG1802	Transcriptional regulator
LW858_RS00005	COG4626	Terminase
LW858_RS00015	COG0740	serine-type endopeptidase activity
LW858_RS00080	COG5632	N-Acetylmuramoyl-L-alanine amidase
LW858_RS00125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LW858_RS00130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LW858_RS00135	COG1116	anion transmembrane transporter activity
LW858_RS00185	COG2270	Major facilitator Superfamily
LW858_RS00220	COG2310	stress, protein
LW858_RS00225	COG2310	stress, protein
LW858_RS00230	COG2310	stress, protein
LW858_RS00235	COG0861	Integral membrane protein TerC family
LW858_RS00245	COG3853	Toxic anion resistance protein (TelA)
LW858_RS00260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LW858_RS00270	COG1295	ribonuclease BN
LW858_RS00275	COG2217	Heavy metal translocating P-type atpase
LW858_RS00280	COG0697	spore germination
LW858_RS00290	COG0681	Belongs to the peptidase S26 family
LW858_RS00300	COG0586	Pfam SNARE associated Golgi protein
LW858_RS00315	COG3871	stress protein (general stress protein 26)
LW858_RS00320	COG0387	Pfam Sodium calcium exchanger
LW858_RS00335	COG0535	radical SAM domain protein
LW858_RS00355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LW858_RS00360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LW858_RS00375	COG3829	transcription factor binding
LW858_RS00385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LW858_RS00415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LW858_RS00415	COG1263	PTS System
LW858_RS00420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LW858_RS00435	COG0463	Glycosyl transferase, family 2
LW858_RS00445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LW858_RS00445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LW858_RS00465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LW858_RS00490	COG1228	amidohydrolase
LW858_RS00495	COG1090	epimerase
LW858_RS00525	COG1988	membrane-bound metal-dependent
LW858_RS00530	COG1194	a g-specific adenine glycosylase
LW858_RS00555	COG1132	(ABC) transporter
LW858_RS00560	COG4129	membrane
LW858_RS00565	COG0067	glutamate synthase
LW858_RS00565	COG0069	glutamate synthase activity
LW858_RS00565	COG0070	glutamate synthase
LW858_RS00575	COG4555	ABC transporter
LW858_RS00595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LW858_RS00600	COG0735	belongs to the Fur family
LW858_RS00720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LW858_RS00745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LW858_RS00755	COG2766	serine protein kinase
LW858_RS00775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LW858_RS00785	COG1585	Membrane protein implicated in regulation of membrane protease activity
LW858_RS00790	COG2268	Band 7 protein
LW858_RS00800	COG3290	protein histidine kinase activity
LW858_RS00805	COG4565	transcriptional regulatory protein
LW858_RS00810	COG2851	Citrate transporter
LW858_RS00855	COG3842	ATPase activity
LW858_RS00860	COG1175	transmembrane transport
LW858_RS00865	COG0395	ABC-type sugar transport system, permease component
LW858_RS00880	COG0745	RESPONSE REGULATOR receiver
LW858_RS00885	COG5002	protein histidine kinase activity
LW858_RS00900	COG4990	cell redox homeostasis
LW858_RS00910	COG3290	protein histidine kinase activity
LW858_RS00915	COG4565	transcriptional regulatory protein
LW858_RS00920	COG3493	citrate carrier protein
LW858_RS00925	COG0281	malic enzyme
LW858_RS00935	COG0697	spore germination
LW858_RS00940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LW858_RS00950	COG5002	protein histidine kinase activity
LW858_RS00970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LW858_RS00975	COG3383	formate dehydrogenase (NAD+) activity
LW858_RS00980	COG2427	Protein of unknown function (DUF1641)
LW858_RS00995	COG0531	amino acid
LW858_RS01000	COG0640	Transcriptional regulator
LW858_RS01005	COG2217	Heavy metal translocating P-type atpase
LW858_RS01010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LW858_RS01025	COG3227	Zinc metalloprotease (Elastase)
LW858_RS01045	COG2720	vancomycin resistance protein
LW858_RS01050	COG1316	TRANSCRIPTIONal
LW858_RS01055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LW858_RS01060	COG0346	lactoylglutathione lyase activity
LW858_RS01065	COG1253	flavin adenine dinucleotide binding
LW858_RS01070	COG1027	Aspartate ammonia-lyase
LW858_RS01075	COG1620	l-lactate permease
LW858_RS01095	COG3104	oligopeptide transport
LW858_RS01100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LW858_RS01115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LW858_RS01120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LW858_RS01140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LW858_RS01150	COG4548	von Willebrand factor, type A
LW858_RS01155	COG0714	Associated with various cellular activities
LW858_RS01175	COG0531	amino acid
LW858_RS01180	COG2188	Transcriptional regulator
LW858_RS01185	COG1263	PTS System
LW858_RS01185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LW858_RS01190	COG0366	Alpha amylase catalytic
LW858_RS01225	COG0697	spore germination
LW858_RS01235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LW858_RS01240	COG1115	amino acid carrier protein
LW858_RS01245	COG1126	abc transporter atp-binding protein
LW858_RS01250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LW858_RS01255	COG0765	amino acid transport
LW858_RS01260	COG0765	amino acid transport
LW858_RS01265	COG0833	amino acid
LW858_RS01280	COG1595	DNA-templated transcription, initiation
LW858_RS01290	COG2378	regulation of single-species biofilm formation
LW858_RS01295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LW858_RS01300	COG5002	protein histidine kinase activity
LW858_RS01325	COG0659	secondary active sulfate transmembrane transporter activity
LW858_RS01340	COG2271	Major facilitator Superfamily
LW858_RS01345	COG1846	Transcriptional regulator
LW858_RS01350	COG0477	Major facilitator Superfamily
LW858_RS01355	COG1609	Transcriptional regulator
LW858_RS01375	COG1172	Belongs to the binding-protein-dependent transport system permease family
LW858_RS01380	COG1879	ABC-type sugar transport system periplasmic component
LW858_RS01420	COG1063	alcohol dehydrogenase
LW858_RS01490	COG1846	Transcriptional regulator
LW858_RS01495	COG1484	DNA-dependent DNA replication
LW858_RS01545	COG0582	viral genome integration into host DNA
LW858_RS01600	COG0840	transmembrane signaling receptor activity
LW858_RS01605	COG3584	3D domain protein
LW858_RS01605	COG1388	LysM domain
LW858_RS01610	COG1476	TRANSCRIPTIONal
LW858_RS01640	COG3104	oligopeptide transport
LW858_RS01645	COG1114	Component of the transport system for branched-chain amino acids
LW858_RS01665	COG1113	amino acid transport
LW858_RS01670	COG2252	PERMEase
LW858_RS01685	COG2153	protein acetylation
LW858_RS01695	COG0475	glutathione-regulated potassium exporter activity
LW858_RS01695	COG0569	domain protein
LW858_RS01715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LW858_RS01725	COG0833	amino acid
LW858_RS01730	COG4990	cell redox homeostasis
LW858_RS01745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LW858_RS01750	COG0697	spore germination
LW858_RS01755	COG0531	amino acid
LW858_RS01765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LW858_RS01770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LW858_RS01775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LW858_RS01775	COG1918	ferrous iron import across plasma membrane
LW858_RS01785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LW858_RS01790	COG0573	inorganic phosphate transmembrane transporter activity
LW858_RS01795	COG0581	inorganic phosphate transmembrane transporter activity
LW858_RS01805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LW858_RS01925	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LW858_RS01945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LW858_RS01950	COG1116	anion transmembrane transporter activity
LW858_RS01955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LW858_RS01960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LW858_RS01965	COG0352	thiamine-phosphate diphosphorylase activity
LW858_RS01970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LW858_RS01975	COG2104	thiamine diphosphate biosynthetic process
LW858_RS01985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LW858_RS01990	COG0351	phosphomethylpyrimidine kinase
LW858_RS02030	COG2205	protein histidine kinase activity
LW858_RS02040	COG1846	Transcriptional regulator
LW858_RS02050	COG2252	PERMEase
LW858_RS02055	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS02080	COG1609	Transcriptional regulator
LW858_RS02100	COG3547	Transposase (IS116 IS110 IS902 family)
LW858_RS02135	COG0778	Nitroreductase
LW858_RS02155	COG2719	SpoVR family
LW858_RS02165	COG1414	Transcriptional regulator
LW858_RS02180	COG0446	pyridine nucleotide-disulphide oxidoreductase
LW858_RS02185	COG1937	Protein conserved in bacteria
LW858_RS02190	COG0425	Belongs to the sulfur carrier protein TusA family
LW858_RS02190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LW858_RS02195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LW858_RS02195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LW858_RS02200	COG0425	Belongs to the sulfur carrier protein TusA family
LW858_RS02205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LW858_RS02215	COG2210	Belongs to the sulfur carrier protein TusA family
LW858_RS02220	COG0730	response to heat
LW858_RS02230	COG1316	TRANSCRIPTIONal
LW858_RS02235	COG0604	alcohol dehydrogenase
LW858_RS02240	COG1283	sodium-dependent phosphate transmembrane transporter activity
LW858_RS02255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LW858_RS02255	COG3711	transcriptional antiterminator
LW858_RS02265	COG1447	Phosphotransferase system cellobiose-specific component IIA
LW858_RS02270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LW858_RS02290	COG3584	3D domain protein
LW858_RS02290	COG1388	LysM domain
LW858_RS02295	COG0577	efflux transmembrane transporter activity
LW858_RS02300	COG1136	(ABC) transporter
LW858_RS02310	COG5522	Integral membrane protein (intg_mem_TP0381)
LW858_RS02325	COG1114	Component of the transport system for branched-chain amino acids
LW858_RS02330	COG3546	catalase activity
LW858_RS02365	COG0586	Pfam SNARE associated Golgi protein
LW858_RS02400	COG0531	amino acid
LW858_RS02405	COG0475	glutathione-regulated potassium exporter activity
LW858_RS02420	COG1737	Transcriptional regulator
LW858_RS02430	COG1263	PTS System
LW858_RS02430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LW858_RS02450	COG2259	Doxx family
LW858_RS02470	COG1522	sequence-specific DNA binding
LW858_RS02475	COG0165	Argininosuccinate lyase
LW858_RS02475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LW858_RS02480	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS02500	COG1309	transcriptional regulator
LW858_RS02505	COG2814	Major facilitator Superfamily
LW858_RS02510	COG1733	regulation of RNA biosynthetic process
LW858_RS02520	COG2249	NAD(P)H dehydrogenase (quinone) activity
LW858_RS02525	COG4533	DNA binding
LW858_RS02530	COG2211	Major facilitator Superfamily
LW858_RS02545	COG0693	protein deglycase activity
LW858_RS02550	COG0693	protein deglycase activity
LW858_RS02550	COG0753	catalase activity
LW858_RS02560	COG0531	amino acid
LW858_RS02565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LW858_RS02580	COG1012	belongs to the aldehyde dehydrogenase family
LW858_RS02585	COG1132	(ABC) transporter
LW858_RS02590	COG1132	(ABC) transporter
LW858_RS02595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LW858_RS02600	COG0765	amino acid transport
LW858_RS02605	COG1126	abc transporter atp-binding protein
LW858_RS02620	COG0189	ligase activity
LW858_RS02680	COG0457	Tetratricopeptide repeat
LW858_RS02695	COG1404	Belongs to the peptidase S8 family
LW858_RS02710	COG3527	Alpha-acetolactate decarboxylase
LW858_RS02720	COG0561	phosphatase activity
LW858_RS02725	COG5632	N-Acetylmuramoyl-L-alanine amidase
LW858_RS02725	COG3409	Peptidoglycan-binding domain 1 protein
LW858_RS02730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LW858_RS02735	COG0318	PFAM AMP-dependent synthetase and ligase
LW858_RS02750	COG0659	secondary active sulfate transmembrane transporter activity
LW858_RS02755	COG2244	polysaccharide biosynthetic process
LW858_RS02785	COG1024	Enoyl-CoA hydratase
LW858_RS02805	COG1363	Peptidase, m42
LW858_RS02840	COG0601	transmembrane transport
LW858_RS02845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LW858_RS02850	COG0444	Belongs to the ABC transporter superfamily
LW858_RS02855	COG4608	Belongs to the ABC transporter superfamily
LW858_RS02865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LW858_RS02885	COG0457	Tetratricopeptide repeat
LW858_RS03045	COG0477	Major facilitator Superfamily
LW858_RS03050	COG3290	protein histidine kinase activity
LW858_RS03055	COG4565	transcriptional regulatory protein
LW858_RS03060	COG3181	Tripartite tricarboxylate transporter family receptor
LW858_RS03085	COG1401	restriction endodeoxyribonuclease activity
LW858_RS03130	COG0305	Participates in initiation and elongation during chromosome replication
LW858_RS03160	COG0477	Major facilitator Superfamily
LW858_RS03180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS03205	COG1073	alpha beta
LW858_RS03250	COG1183	phosphatidylcholine synthase activity
LW858_RS03265	COG2376	Dihydroxyacetone kinase
LW858_RS03275	COG2376	Dihydroxyacetone kinase
LW858_RS03310	COG2373	Large extracellular alpha-helical protein
LW858_RS03330	COG0596	Alpha beta hydrolase
LW858_RS03400	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LW858_RS03420	COG0420	3'-5' exonuclease activity
LW858_RS03425	COG4717	serine-type aminopeptidase activity
LW858_RS03435	COG4974	Belongs to the 'phage' integrase family
LW858_RS03575	COG4824	toxin secretion phage lysis holin
LW858_RS03580	COG1388	LysM domain
LW858_RS03580	COG3409	Peptidoglycan-binding domain 1 protein
LW858_RS03580	COG5632	N-Acetylmuramoyl-L-alanine amidase
LW858_RS03605	COG0346	lactoylglutathione lyase activity
LW858_RS03610	COG0346	lactoylglutathione lyase activity
LW858_RS03625	COG2267	carboxylic ester hydrolase activity
LW858_RS03640	COG1695	Transcriptional regulator
LW858_RS03645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LW858_RS03655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LW858_RS03660	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LW858_RS03670	COG3973	AAA domain
LW858_RS03680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LW858_RS03700	COG4980	gas vesicle protein
LW858_RS03705	COG0537	adenosine 5'-monophosphoramidase activity
LW858_RS03710	COG1131	(ABC) transporter
LW858_RS03715	COG4473	ABC transporter
LW858_RS03740	COG3402	PFAM membrane-flanked domain
LW858_RS03780	COG0697	spore germination
LW858_RS03785	COG3402	PFAM membrane-flanked domain
LW858_RS03790	COG3428	Bacterial PH domain
LW858_RS03795	COG2329	Antibiotic biosynthesis monooxygenase
LW858_RS03800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LW858_RS03815	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LW858_RS03850	COG1309	transcriptional regulator
LW858_RS03855	COG1511	domain protein
LW858_RS03875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS03880	COG1609	Transcriptional regulator
LW858_RS03890	COG1234	tRNA 3'-trailer cleavage
LW858_RS03895	COG0095	Lipoate-protein ligase
LW858_RS03905	COG0318	PFAM AMP-dependent synthetase and ligase
LW858_RS03925	COG4208	sulfate ABC transporter
LW858_RS04075	COG1073	alpha beta
LW858_RS04080	COG1408	metallophosphoesterase
LW858_RS04085	COG1078	dGTPase activity
LW858_RS04095	COG1595	DNA-templated transcription, initiation
LW858_RS04100	COG2207	Transcriptional regulator
LW858_RS04100	COG3708	Transcriptional regulator
LW858_RS04105	COG2205	protein histidine kinase activity
LW858_RS04110	COG0745	RESPONSE REGULATOR receiver
LW858_RS04130	COG0501	Belongs to the peptidase M48B family
LW858_RS04135	COG0840	transmembrane signaling receptor activity
LW858_RS04140	COG3693	PFAM glycoside hydrolase, family 10
LW858_RS04150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LW858_RS04160	COG2224	Isocitrate lyase
LW858_RS04200	COG0398	Pfam SNARE associated Golgi protein
LW858_RS04260	COG0179	Fumarylacetoacetate (FAA) hydrolase
LW858_RS04285	COG0367	asparagine synthase
LW858_RS04300	COG0753	catalase activity
LW858_RS04310	COG0004	ammonium transporteR
LW858_RS04335	COG2996	Protein conserved in bacteria
LW858_RS04340	COG3209	COG3209 Rhs family protein
LW858_RS04375	COG3209	COG3209 Rhs family protein
LW858_RS04400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LW858_RS04415	COG0561	phosphatase activity
LW858_RS04435	COG2267	carboxylic ester hydrolase activity
LW858_RS04455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LW858_RS04460	COG5504	Zn-dependent protease
LW858_RS04470	COG0180	Tryptophanyl-tRNA synthetase
LW858_RS04485	COG0601	transmembrane transport
LW858_RS04490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LW858_RS04495	COG0444	Belongs to the ABC transporter superfamily
LW858_RS04500	COG4608	Belongs to the ABC transporter superfamily
LW858_RS04505	COG0534	Mate efflux family protein
LW858_RS04525	COG0861	Integral membrane protein TerC family
LW858_RS04545	COG1164	Oligoendopeptidase f
LW858_RS04560	COG2346	COG2346, Truncated hemoglobins
LW858_RS04565	COG4116	CYTH
LW858_RS04575	COG0582	viral genome integration into host DNA
LW858_RS04775	COG5632	N-Acetylmuramoyl-L-alanine amidase
LW858_RS04790	COG4555	ABC transporter
LW858_RS04815	COG1136	(ABC) transporter
LW858_RS04820	COG0577	efflux transmembrane transporter activity
LW858_RS04835	COG2357	RelA SpoT domain protein
LW858_RS04845	COG0564	pseudouridine synthase activity
LW858_RS04860	COG0772	Belongs to the SEDS family
LW858_RS04865	COG1216	Glycosyl transferase, family 2
LW858_RS04885	COG0463	Glycosyl transferase, family 2
LW858_RS04885	COG0457	Tetratricopeptide repeat
LW858_RS04910	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LW858_RS04925	COG1091	dTDP-4-dehydrorhamnose reductase activity
LW858_RS04970	COG2153	protein acetylation
LW858_RS04980	COG2382	esterase
LW858_RS05005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LW858_RS05015	COG0512	Glutamine amidotransferase of anthranilate synthase
LW858_RS05015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LW858_RS05050	COG1620	l-lactate permease
LW858_RS05055	COG5634	Uncharacterized conserved protein (DUF2278)
LW858_RS05105	COG0508	dehydrogenase complex catalyzes the overall conversion of
LW858_RS05115	COG1476	TRANSCRIPTIONal
LW858_RS05175	COG1686	Belongs to the peptidase S11 family
LW858_RS05180	COG0681	Belongs to the peptidase S26 family
LW858_RS05215	COG1012	belongs to the aldehyde dehydrogenase family
LW858_RS05225	COG1176	ABC-type spermidine putrescine transport system, permease component I
LW858_RS05230	COG1177	transmembrane transport
LW858_RS05245	COG2409	Drug exporters of the RND superfamily
LW858_RS05255	COG0564	pseudouridine synthase activity
LW858_RS05265	COG2340	Cysteine-rich secretory protein family
LW858_RS05270	COG0247	lactate metabolic process
LW858_RS05275	COG0277	FAD linked oxidase domain protein
LW858_RS05280	COG3835	regulator
LW858_RS05290	COG0745	RESPONSE REGULATOR receiver
LW858_RS05295	COG5002	protein histidine kinase activity
LW858_RS05300	COG2186	Transcriptional regulator
LW858_RS05320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LW858_RS05330	COG2116	formate transmembrane transporter activity
LW858_RS05335	COG0861	Integral membrane protein TerC family
LW858_RS05340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LW858_RS05350	COG2030	dehydratase
LW858_RS05370	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS05375	COG3243	poly(R)-hydroxyalkanoic acid synthase
LW858_RS05385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LW858_RS05400	COG1840	ABC-type Fe3 transport system, periplasmic component
LW858_RS05405	COG3842	ATPase activity
LW858_RS05430	COG1349	DNA-binding transcription factor activity
LW858_RS05450	COG0235	Class ii aldolase
LW858_RS05460	COG2861	carbohydrate metabolic process
LW858_RS05470	COG3852	Histidine kinase
LW858_RS05475	COG1846	Transcriptional regulator
LW858_RS05485	COG2318	DinB family
LW858_RS05495	COG5002	protein histidine kinase activity
LW858_RS05505	COG0720	synthase
LW858_RS05520	COG4873	Protein conserved in bacteria
LW858_RS05555	COG1780	Probably involved in ribonucleotide reductase function
LW858_RS05560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LW858_RS05565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LW858_RS05570	COG1725	Transcriptional regulator
LW858_RS05575	COG1131	(ABC) transporter
LW858_RS05585	COG1131	(ABC) transporter
LW858_RS05605	COG1522	sequence-specific DNA binding
LW858_RS05615	COG1335	isochorismatase
LW858_RS05630	COG1619	proteins homologs of microcin C7 resistance protein MccF
LW858_RS05635	COG2070	2-Nitropropane dioxygenase
LW858_RS05640	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LW858_RS05650	COG1696	Membrane protein involved in D-alanine export
LW858_RS05675	COG0716	FMN binding
LW858_RS05730	COG1846	Transcriptional regulator
LW858_RS05740	COG1301	dicarboxylic acid transport
LW858_RS05745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LW858_RS05750	COG4709	membrane
LW858_RS05755	COG3874	Sporulation protein YtfJ
LW858_RS05775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LW858_RS05780	COG0028	Belongs to the TPP enzyme family
LW858_RS05785	COG0440	acetolactate synthase activity
LW858_RS05860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LW858_RS05875	COG1183	phosphatidylcholine synthase activity
LW858_RS05880	COG1368	sulfuric ester hydrolase activity
LW858_RS05890	COG0019	diaminopimelate decarboxylase activity
LW858_RS05910	COG0529	Catalyzes the synthesis of activated sulfate
LW858_RS05915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LW858_RS05935	COG1648	precorrin-2 dehydrogenase activity
LW858_RS05940	COG0733	neurotransmitter:sodium symporter activity
LW858_RS05965	COG1757	Na H antiporter
LW858_RS05980	COG4758	membrane
LW858_RS05985	COG4585	Histidine kinase
LW858_RS05990	COG2197	response regulator
LW858_RS06055	COG0730	response to heat
LW858_RS06060	COG0306	phosphate transporter
LW858_RS06065	COG1392	Phosphate transport regulator
LW858_RS06070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LW858_RS06085	COG3852	Histidine kinase
LW858_RS06090	COG1801	Protein of unknown function DUF72
LW858_RS06110	COG0582	viral genome integration into host DNA
LW858_RS06115	COG5002	protein histidine kinase activity
LW858_RS06130	COG0392	lysyltransferase activity
LW858_RS06130	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LW858_RS06145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LW858_RS06150	COG1686	Belongs to the peptidase S11 family
LW858_RS06155	COG2715	membrane protein required for spore maturation
LW858_RS06160	COG0700	Nucleoside recognition
LW858_RS06165	COG1187	pseudouridine synthase activity
LW858_RS06175	COG1333	cytochrome c biogenesis protein
LW858_RS06180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LW858_RS06185	COG0745	RESPONSE REGULATOR receiver
LW858_RS06190	COG5002	protein histidine kinase activity
LW858_RS06195	COG2096	Adenosyltransferase
LW858_RS06210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LW858_RS06215	COG1141	Ferredoxin
LW858_RS06225	COG0514	ATP-dependent DNA helicase (RecQ)
LW858_RS06230	COG1266	CAAX protease self-immunity
LW858_RS06240	COG1408	metallophosphoesterase
LW858_RS06245	COG0789	Transcriptional regulator
LW858_RS06255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LW858_RS06275	COG0492	ferredoxin-NADP+ reductase activity
LW858_RS06280	COG0252	asparaginase activity
LW858_RS06350	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LW858_RS06365	COG0142	geranyltranstransferase activity
LW858_RS06375	COG0142	geranyltranstransferase activity
LW858_RS06400	COG0457	Tetratricopeptide repeat
LW858_RS06420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LW858_RS06425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LW858_RS06425	COG2010	Cytochrome c
LW858_RS06430	COG4347	Protein of unknown function (DUF1405)
LW858_RS06445	COG2738	Putative neutral zinc metallopeptidase
LW858_RS06455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LW858_RS06460	COG1694	Mazg nucleotide pyrophosphohydrolase
LW858_RS06480	COG0438	transferase activity, transferring glycosyl groups
LW858_RS06515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LW858_RS06515	COG1199	ATP-dependent helicase activity
LW858_RS06535	COG3935	DnaD domain protein
LW858_RS06540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LW858_RS06550	COG4499	WXG100 protein secretion system (Wss), protein YukC
LW858_RS06550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LW858_RS06605	COG0116	Belongs to the methyltransferase superfamily
LW858_RS06615	COG1199	ATP-dependent helicase activity
LW858_RS06620	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LW858_RS06630	COG0024	Methionine aminopeptidase
LW858_RS06650	COG2311	Membrane
LW858_RS06655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LW858_RS06665	COG0456	acetyltransferase
LW858_RS06715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LW858_RS06730	COG3944	biosynthesis protein
LW858_RS06740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LW858_RS06755	COG1215	transferase activity, transferring glycosyl groups
LW858_RS06760	COG0438	transferase activity, transferring glycosyl groups
LW858_RS06775	COG0454	-acetyltransferase
LW858_RS06795	COG0328	RNA-DNA hybrid ribonuclease activity
LW858_RS06830	COG3403	YqcI/YcgG family
LW858_RS06835	COG1280	lysine exporter protein (LysE YggA)
LW858_RS06855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LW858_RS06860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LW858_RS06870	COG0475	glutathione-regulated potassium exporter activity
LW858_RS06875	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LW858_RS06885	COG4978	Transcriptional regulator
LW858_RS06885	COG0789	Transcriptional regulator
LW858_RS06895	COG2323	membrane
LW858_RS06900	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LW858_RS06935	COG1923	regulation of RNA biosynthetic process
LW858_RS06945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LW858_RS06950	COG1360	Flagellar Motor Protein
LW858_RS06955	COG2201	protein-glutamate methylesterase activity
LW858_RS06960	COG0643	Histidine kinase
LW858_RS06960	COG2198	Histidine kinase
LW858_RS06965	COG1776	CheC inhibitor of MCP methylation
LW858_RS06965	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LW858_RS06980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LW858_RS07000	COG1256	bacterial-type flagellum assembly
LW858_RS07005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LW858_RS07025	COG1815	bacterial-type flagellum-dependent cell motility
LW858_RS07030	COG1558	bacterial-type flagellum-dependent cell motility
LW858_RS07040	COG1766	The M ring may be actively involved in energy transduction
LW858_RS07045	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LW858_RS07055	COG1157	protein secretion by the type III secretion system
LW858_RS07075	COG1749	Flagellar hook protein flgE
LW858_RS07090	COG0784	Response regulator, receiver
LW858_RS07090	COG0835	chemotaxis
LW858_RS07100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LW858_RS07105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LW858_RS07110	COG0741	lytic transglycosylase activity
LW858_RS07120	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LW858_RS07125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LW858_RS07125	COG1776	CheC inhibitor of MCP methylation
LW858_RS07135	COG1338	Plays a role in the flagellum-specific transport system
LW858_RS07140	COG1987	bacterial-type flagellum assembly
LW858_RS07150	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LW858_RS07155	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LW858_RS07160	COG1419	protein localization to endoplasmic reticulum
LW858_RS07165	COG4786	Flagellar basal body rod
LW858_RS07170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LW858_RS07205	COG2329	Antibiotic biosynthesis monooxygenase
LW858_RS07290	COG4641	Protein conserved in bacteria
LW858_RS07355	COG0406	alpha-ribazole phosphatase activity
LW858_RS07385	COG0367	asparagine synthase
LW858_RS07415	COG1802	Transcriptional regulator
LW858_RS07420	COG0697	spore germination
LW858_RS07430	COG0523	cobalamin synthesis protein
LW858_RS07435	COG0701	Predicted permease
LW858_RS07450	COG1757	Na H antiporter
LW858_RS07455	COG0789	Transcriptional regulator
LW858_RS07480	COG0534	Mate efflux family protein
LW858_RS07485	COG3340	Belongs to the peptidase S51 family
LW858_RS07505	COG0785	Cytochrome C biogenesis protein
LW858_RS07510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LW858_RS07540	COG2733	membrane
LW858_RS07575	COG1131	(ABC) transporter
LW858_RS07590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LW858_RS07595	COG0528	UMP kinase activity
LW858_RS07610	COG1027	Aspartate ammonia-lyase
LW858_RS07615	COG0281	malic enzyme
LW858_RS07620	COG4191	Histidine kinase
LW858_RS07625	COG0784	Response regulator, receiver
LW858_RS07635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LW858_RS07680	COG2814	Major facilitator Superfamily
LW858_RS07695	COG1695	Transcriptional regulator
LW858_RS07710	COG0477	Major facilitator Superfamily
LW858_RS07720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LW858_RS07725	COG2223	nitrite transmembrane transporter activity
LW858_RS07730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LW858_RS07750	COG0733	neurotransmitter:sodium symporter activity
LW858_RS07760	COG5566	PFAM Mor transcription activator
LW858_RS07765	COG2323	membrane
LW858_RS07785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LW858_RS07795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LW858_RS07800	COG0028	Belongs to the TPP enzyme family
LW858_RS07820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LW858_RS07845	COG2814	Major facilitator Superfamily
LW858_RS07860	COG3279	Response regulator of the LytR AlgR family
LW858_RS07865	COG0427	acetyl-CoA hydrolase
LW858_RS07885	COG4166	transmembrane transport
LW858_RS07915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS07935	COG1914	H( )-stimulated, divalent metal cation uptake system
LW858_RS07950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LW858_RS07955	COG0531	amino acid
LW858_RS08000	COG1309	transcriptional regulator
LW858_RS08005	COG2390	Transcriptional regulator
LW858_RS08030	COG4846	Membrane protein involved in cytochrome C biogenesis
LW858_RS08040	COG0006	proline dipeptidase activity
LW858_RS08050	COG2132	Multicopper oxidase
LW858_RS08060	COG1309	transcriptional regulator
LW858_RS08065	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
LW858_RS08085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LW858_RS08105	COG1114	Component of the transport system for branched-chain amino acids
LW858_RS08115	COG1276	copper resistance
LW858_RS08115	COG2372	response to copper ion
LW858_RS08120	COG4549	nuclear export factor GLE1
LW858_RS08130	COG0583	DNA-binding transcription factor activity
LW858_RS08135	COG1959	2 iron, 2 sulfur cluster binding
LW858_RS08140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LW858_RS08145	COG0778	Nitroreductase
LW858_RS08155	COG0628	permease
LW858_RS08165	COG1231	oxidoreductase activity
LW858_RS08170	COG0523	cobalamin synthesis protein
LW858_RS08180	COG0411	ABC transporter
LW858_RS08200	COG0583	DNA-binding transcription factor activity
LW858_RS08230	COG1271	oxidase subunit
LW858_RS08235	COG1294	oxidase, subunit
LW858_RS08240	COG4988	ABC transporter
LW858_RS08245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LW858_RS08255	COG1216	Glycosyl transferase, family 2
LW858_RS08295	COG1686	Belongs to the peptidase S11 family
LW858_RS08310	COG0791	NLP P60 protein
LW858_RS08310	COG1388	LysM domain
LW858_RS08320	COG1132	(ABC) transporter
LW858_RS08325	COG0745	RESPONSE REGULATOR receiver
LW858_RS08330	COG5002	protein histidine kinase activity
LW858_RS08340	COG0300	oxidoreductase activity
LW858_RS08370	COG0460	homoserine dehydrogenase
LW858_RS08395	COG1316	TRANSCRIPTIONal
LW858_RS08410	COG0745	RESPONSE REGULATOR receiver
LW858_RS08415	COG5002	protein histidine kinase activity
LW858_RS08430	COG1285	pathogenesis
LW858_RS08435	COG1247	-acetyltransferase
LW858_RS08455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LW858_RS08465	COG1082	Xylose isomerase domain protein TIM barrel
LW858_RS08475	COG2814	Major facilitator Superfamily
LW858_RS08480	COG1279	arginine transmembrane transporter activity
LW858_RS08485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LW858_RS08495	COG1752	Esterase of the alpha-beta hydrolase superfamily
LW858_RS08535	COG2002	toxin-antitoxin pair type II binding
LW858_RS08540	COG1404	Belongs to the peptidase S8 family
LW858_RS08545	COG3842	ATPase activity
LW858_RS08550	COG2508	Transcriptional regulator
LW858_RS08560	COG1653	transport
LW858_RS08565	COG1175	transmembrane transport
LW858_RS08570	COG0395	ABC-type sugar transport system, permease component
LW858_RS08575	COG5426	von Willebrand factor, type A
LW858_RS08585	COG1940	carbohydrate kinase activity
LW858_RS08590	COG2222	sugar isomerase
LW858_RS08600	COG1105	Belongs to the carbohydrate kinase PfkB family
LW858_RS08605	COG3684	Belongs to the aldolase LacD family
LW858_RS08610	COG0366	Alpha amylase catalytic
LW858_RS08615	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LW858_RS08620	COG0640	Transcriptional regulator
LW858_RS08625	COG0667	Aldo Keto reductase
LW858_RS08630	COG2814	Major facilitator Superfamily
LW858_RS08635	COG3152	Membrane
LW858_RS08660	COG0840	transmembrane signaling receptor activity
LW858_RS08675	COG3949	Membrane
LW858_RS08680	COG0783	Belongs to the Dps family
LW858_RS08695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LW858_RS08705	COG1231	oxidoreductase activity
LW858_RS08710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS08715	COG4989	oxidoreductase activity
LW858_RS08720	COG0523	cobalamin synthesis protein
LW858_RS08725	COG0456	acetyltransferase
LW858_RS08730	COG0803	Belongs to the bacterial solute-binding protein 9 family
LW858_RS08740	COG0702	epimerase
LW858_RS08750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LW858_RS08760	COG4166	transmembrane transport
LW858_RS08785	COG5337	Spore coat protein CotH
LW858_RS08790	COG1051	belongs to the nudix hydrolase family
LW858_RS08795	COG0586	Pfam SNARE associated Golgi protein
LW858_RS08800	COG2244	polysaccharide biosynthetic process
LW858_RS08810	COG0701	Predicted permease
LW858_RS08815	COG3689	TIGRFAM TIGR03943 family protein
LW858_RS08820	COG1607	acyl-coa hydrolase
LW858_RS08845	COG0702	epimerase
LW858_RS08850	COG2839	Protein conserved in bacteria
LW858_RS08855	COG1253	flavin adenine dinucleotide binding
LW858_RS08870	COG1114	Component of the transport system for branched-chain amino acids
LW858_RS08875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LW858_RS08895	COG0860	N-Acetylmuramoyl-L-alanine amidase
LW858_RS08905	COG1876	peptidase activity
LW858_RS08930	COG2211	Major facilitator Superfamily
LW858_RS08945	COG0860	N-Acetylmuramoyl-L-alanine amidase
LW858_RS08955	COG0561	phosphatase activity
LW858_RS08970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LW858_RS08990	COG1819	glycosyl
LW858_RS08995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LW858_RS09000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LW858_RS09030	COG0456	acetyltransferase
LW858_RS09065	COG4499	WXG100 protein secretion system (Wss), protein YukC
LW858_RS09175	COG3874	Sporulation protein YtfJ
LW858_RS09200	COG2226	methyltransferase
LW858_RS09225	COG0346	lactoylglutathione lyase activity
LW858_RS09235	COG0604	alcohol dehydrogenase
LW858_RS09240	COG1595	DNA-templated transcription, initiation
LW858_RS09250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LW858_RS09260	COG0426	domain, Protein
LW858_RS09260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LW858_RS09270	COG0386	Belongs to the glutathione peroxidase family
LW858_RS09275	COG1305	Transglutaminase-like
LW858_RS09280	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
LW858_RS09285	COG0714	Associated with various cellular activities
LW858_RS09290	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LW858_RS09295	COG1140	nitrate reductase beta subunit
LW858_RS09300	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LW858_RS09305	COG2181	nitrate reductase activity
LW858_RS09310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LW858_RS09315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LW858_RS09320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LW858_RS09325	COG0303	'Molybdopterin
LW858_RS09330	COG0314	molybdopterin synthase activity
LW858_RS09340	COG2223	nitrite transmembrane transporter activity
LW858_RS09360	COG1648	precorrin-2 dehydrogenase activity
LW858_RS09370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LW858_RS09370	COG1587	Uroporphyrinogen-III synthase
LW858_RS09375	COG2146	nitrite reductase [NAD(P)H] activity
LW858_RS09380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LW858_RS09385	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
LW858_RS09420	COG2359	stage V sporulation protein S
LW858_RS09445	COG0457	Tetratricopeptide repeat
LW858_RS09460	COG1418	mRNA catabolic process
LW858_RS09465	COG0488	(ABC) transporter
LW858_RS09480	COG0629	single-stranded DNA binding
LW858_RS09485	COG1413	lyase activity
LW858_RS09500	COG2136	Putative SAM-dependent methyltransferase
LW858_RS09500	COG2521	methyltransferase
LW858_RS09505	COG0018	arginyl-trna synthetase
LW858_RS09545	COG0017	Asparaginyl-tRNA synthetase
LW858_RS09550	COG1929	Belongs to the glycerate kinase type-1 family
LW858_RS09560	COG0745	RESPONSE REGULATOR receiver
LW858_RS09565	COG5002	protein histidine kinase activity
LW858_RS09565	COG3850	Histidine kinase
LW858_RS09580	COG0733	neurotransmitter:sodium symporter activity
LW858_RS09605	COG2610	gluconate transmembrane transporter activity
LW858_RS09615	COG1794	racemase activity, acting on amino acids and derivatives
LW858_RS09625	COG0456	acetyltransferase
LW858_RS09635	COG3655	Transcriptional regulator
LW858_RS09640	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LW858_RS09650	COG1131	(ABC) transporter
LW858_RS09655	COG4473	ABC transporter
LW858_RS09665	COG0546	phosphoglycolate phosphatase activity
LW858_RS09680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LW858_RS09695	COG0768	penicillin binding
LW858_RS09705	COG0204	Acyl-transferase
LW858_RS09710	COG1272	protein, Hemolysin III
LW858_RS09720	COG0805	protein transport
LW858_RS09730	COG1307	EDD domain protein, DegV family
LW858_RS09740	COG1999	signal sequence binding
LW858_RS09750	COG0071	Belongs to the small heat shock protein (HSP20) family
LW858_RS09755	COG0367	asparagine synthase
LW858_RS09770	COG0860	N-Acetylmuramoyl-L-alanine amidase
LW858_RS09775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LW858_RS09780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LW858_RS09795	COG1335	isochorismatase
LW858_RS09805	COG0668	transmembrane transport
LW858_RS09810	COG4585	Histidine kinase
LW858_RS09810	COG2203	Gaf domain
LW858_RS09815	COG2197	response regulator
LW858_RS09820	COG1737	Transcriptional regulator
LW858_RS09825	COG0384	phenazine biosynthesis protein PhzF
LW858_RS09830	COG1064	alcohol dehydrogenase
LW858_RS09855	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LW858_RS09890	COG0517	IMP dehydrogenase activity
LW858_RS09890	COG1125	glycine betaine transport
LW858_RS09895	COG1174	glycine betaine transport
LW858_RS09930	COG1253	flavin adenine dinucleotide binding
LW858_RS09935	COG1012	belongs to the aldehyde dehydrogenase family
LW858_RS09940	COG5506	Protein of unknown function (DUF1694)
LW858_RS09955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LW858_RS09960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LW858_RS09965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LW858_RS09970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LW858_RS09975	COG0456	acetyltransferase
LW858_RS09980	COG3829	transcription factor binding
LW858_RS09985	COG1509	lysine 2,3-aminomutase activity
LW858_RS10020	COG3064	Membrane
LW858_RS10020	COG0515	serine threonine protein kinase
LW858_RS10020	COG4991	sh3 domain protein
LW858_RS10030	COG0671	phosphoesterase, PA-phosphatase related
LW858_RS10035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LW858_RS10040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LW858_RS10125	COG0300	oxidoreductase activity
LW858_RS10145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LW858_RS10145	COG4499	WXG100 protein secretion system (Wss), protein YukC
LW858_RS10155	COG2814	Major facilitator Superfamily
LW858_RS10160	COG4841	protein insertion into membrane
LW858_RS10165	COG0372	Belongs to the citrate synthase family
LW858_RS10170	COG2079	MmgE PrpD family protein
LW858_RS10175	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LW858_RS10180	COG1960	acyl-CoA dehydrogenase activity
LW858_RS10185	COG2084	Dehydrogenase
LW858_RS10200	COG1280	lysine exporter protein (LysE YggA)
LW858_RS10205	COG1024	Enoyl-CoA hydratase
LW858_RS10220	COG0420	3'-5' exonuclease activity
LW858_RS10225	COG0419	ATPase involved in DNA repair
LW858_RS10250	COG2223	nitrite transmembrane transporter activity
LW858_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS10260	COG1169	isochorismate synthase
LW858_RS10265	COG1021	2,3-dihydroxybenzoate-AMP ligase
LW858_RS10270	COG3433	isochorismatase activity
LW858_RS10270	COG1535	isochorismatase
LW858_RS10275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LW858_RS10280	COG3251	PFAM MbtH domain protein
LW858_RS10285	COG2814	Major facilitator Superfamily
LW858_RS10300	COG0776	regulation of translation
LW858_RS10310	COG2318	DinB family
LW858_RS10330	COG1115	amino acid carrier protein
LW858_RS10350	COG1187	pseudouridine synthase activity
LW858_RS10355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LW858_RS10360	COG1136	(ABC) transporter
LW858_RS10400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LW858_RS10415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LW858_RS10445	COG1247	-acetyltransferase
LW858_RS10475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LW858_RS10485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS10515	COG0583	DNA-binding transcription factor activity
LW858_RS10520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LW858_RS10540	COG0583	DNA-binding transcription factor activity
LW858_RS10545	COG2258	MOSC domain
LW858_RS10560	COG1132	(ABC) transporter
LW858_RS10565	COG1132	(ABC) transporter
LW858_RS10595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LW858_RS10600	COG1595	DNA-templated transcription, initiation
LW858_RS10655	COG2971	BadF BadG BcrA BcrD
LW858_RS10665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LW858_RS10675	COG1846	Transcriptional regulator
LW858_RS10690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LW858_RS10710	COG1309	transcriptional regulator
LW858_RS10730	COG3615	Tellurite resistance protein tehB
LW858_RS10730	COG0500	methyltransferase
LW858_RS10740	COG2226	methyltransferase
LW858_RS10745	COG3961	Belongs to the TPP enzyme family
LW858_RS10750	COG1846	Transcriptional regulator
LW858_RS10780	COG2195	Cleaves the N-terminal amino acid of tripeptides
LW858_RS10805	COG2002	toxin-antitoxin pair type II binding
LW858_RS10815	COG0730	response to heat
LW858_RS10820	COG0110	maltose O-acetyltransferase activity
LW858_RS10840	COG2814	Major facilitator Superfamily
LW858_RS10875	COG2312	Erythromycin esterase
LW858_RS10885	COG0741	lytic transglycosylase activity
LW858_RS10890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS10930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LW858_RS10935	COG0768	penicillin binding
LW858_RS10940	COG1595	DNA-templated transcription, initiation
LW858_RS10950	COG0768	penicillin binding
LW858_RS10955	COG0768	penicillin binding
LW858_RS10965	COG1408	metallophosphoesterase
LW858_RS10975	COG1131	(ABC) transporter
LW858_RS10985	COG1309	transcriptional regulator
LW858_RS11005	COG1960	acyl-CoA dehydrogenase activity
LW858_RS11010	COG0439	Biotin carboxylase
LW858_RS11015	COG0511	ligase activity, forming carbon-carbon bonds
LW858_RS11020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LW858_RS11025	COG1024	Enoyl-CoA hydratase
LW858_RS11030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LW858_RS11035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LW858_RS11070	COG1686	Belongs to the peptidase S11 family
LW858_RS11095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LW858_RS11110	COG3227	Zinc metalloprotease (Elastase)
LW858_RS11115	COG2207	Transcriptional regulator
LW858_RS11145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LW858_RS11155	COG2814	Major facilitator Superfamily
LW858_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS11165	COG1733	regulation of RNA biosynthetic process
LW858_RS11210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LW858_RS11235	COG1063	alcohol dehydrogenase
LW858_RS11245	COG2323	membrane
LW858_RS11250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LW858_RS11260	COG3386	PFAM SMP-30 Gluconolaconase
LW858_RS11270	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LW858_RS11275	COG3773	Cell wall hydrolase
LW858_RS11285	COG0745	RESPONSE REGULATOR receiver
LW858_RS11290	COG2205	protein histidine kinase activity
LW858_RS11300	COG0488	(ABC) transporter
LW858_RS11310	COG1136	(ABC) transporter
LW858_RS11315	COG0577	efflux transmembrane transporter activity
LW858_RS11340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LW858_RS11350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LW858_RS11410	COG2124	cytochrome p450
LW858_RS11445	COG0561	phosphatase activity
LW858_RS11455	COG5002	protein histidine kinase activity
LW858_RS11460	COG0768	penicillin binding
LW858_RS11470	COG1819	glycosyl
LW858_RS11475	COG1794	racemase activity, acting on amino acids and derivatives
LW858_RS11500	COG2205	protein histidine kinase activity
LW858_RS11510	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LW858_RS11515	COG0604	alcohol dehydrogenase
LW858_RS11520	COG0671	phosphoesterase, PA-phosphatase related
LW858_RS11525	COG0768	penicillin binding
LW858_RS11580	COG2814	Major facilitator Superfamily
LW858_RS11595	COG0584	glycerophosphoryl diester phosphodiesterase
LW858_RS11615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LW858_RS11620	COG0697	spore germination
LW858_RS11655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LW858_RS11665	COG2223	nitrite transmembrane transporter activity
LW858_RS11685	COG0592	DNA-directed DNA polymerase activity
LW858_RS11705	COG0251	oxidation-reduction process
LW858_RS11730	COG4667	esterase of the alpha-beta hydrolase superfamily
LW858_RS11770	COG0322	excinuclease ABC activity
LW858_RS11800	COG1131	(ABC) transporter
LW858_RS11820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LW858_RS11855	COG1011	Hydrolase
LW858_RS11870	COG1073	alpha beta
LW858_RS11875	COG1523	belongs to the glycosyl hydrolase 13 family
LW858_RS11880	COG3227	Zinc metalloprotease (Elastase)
LW858_RS11885	COG0737	Belongs to the 5'-nucleotidase family
LW858_RS11905	COG0201	protein transport
LW858_RS11910	COG0697	spore germination
LW858_RS11915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LW858_RS11920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LW858_RS11950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS11965	COG2959	enzyme of heme biosynthesis
LW858_RS12005	COG1309	transcriptional regulator
LW858_RS12025	COG3284	Transcriptional regulator
LW858_RS12040	COG1349	DNA-binding transcription factor activity
LW858_RS12065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LW858_RS12070	COG0508	dehydrogenase complex catalyzes the overall conversion of
LW858_RS12075	COG0022	dehydrogenase e1 component
LW858_RS12080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LW858_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS12120	COG4176	ABC-type proline glycine betaine transport system permease component
LW858_RS12125	COG4175	Glycine betaine
LW858_RS12125	COG0517	IMP dehydrogenase activity
LW858_RS12155	COG2153	protein acetylation
LW858_RS12160	COG3397	chitin binding
LW858_RS12165	COG1819	glycosyl
LW858_RS12185	COG2205	protein histidine kinase activity
LW858_RS12190	COG2226	methyltransferase
LW858_RS12195	COG2315	Protein conserved in bacteria
LW858_RS12240	COG0456	acetyltransferase
LW858_RS12255	COG3973	AAA domain
LW858_RS12270	COG0514	ATP-dependent DNA helicase (RecQ)
LW858_RS12305	COG4637	Psort location Cytoplasmic, score
LW858_RS12320	COG3397	chitin binding
LW858_RS12335	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LW858_RS12340	COG1115	amino acid carrier protein
LW858_RS12345	COG1012	belongs to the aldehyde dehydrogenase family
LW858_RS12350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LW858_RS12360	COG3938	Belongs to the proline racemase family
LW858_RS12365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LW858_RS12405	COG1078	dGTPase activity
LW858_RS12410	COG0586	Pfam SNARE associated Golgi protein
LW858_RS12420	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LW858_RS12455	COG4948	Mandelate Racemase Muconate Lactonizing
LW858_RS12470	COG0667	Aldo Keto reductase
LW858_RS12515	COG5002	protein histidine kinase activity
LW858_RS12515	COG3850	Histidine kinase
LW858_RS12520	COG0745	RESPONSE REGULATOR receiver
LW858_RS12555	COG1164	Oligoendopeptidase f
LW858_RS12560	COG1307	EDD domain protein, DegV family
LW858_RS12605	COG2814	Major facilitator Superfamily
LW858_RS12615	COG1664	Polymer-forming cytoskeletal
LW858_RS12620	COG0789	Transcriptional regulator
LW858_RS12625	COG4533	DNA binding
LW858_RS12630	COG0477	Major facilitator Superfamily
LW858_RS12630	COG2814	Major facilitator Superfamily
LW858_RS12650	COG2261	transglycosylase associated protein
LW858_RS12665	COG2226	methyltransferase
LW858_RS12700	COG0436	Aminotransferase
LW858_RS12705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LW858_RS12760	COG0628	permease
LW858_RS12775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LW858_RS12780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LW858_RS12785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LW858_RS12825	COG2746	aminoglycoside 3-N-acetyltransferase activity
LW858_RS12835	COG0697	spore germination
LW858_RS12840	COG2318	DinB family
LW858_RS12860	COG4912	Dna alkylation repair
LW858_RS12865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LW858_RS12870	COG0346	lactoylglutathione lyase activity
LW858_RS12875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LW858_RS12890	COG0861	Integral membrane protein TerC family
LW858_RS12895	COG1368	sulfuric ester hydrolase activity
LW858_RS12900	COG0488	(ABC) transporter
LW858_RS12910	COG1033	growth of symbiont in host cell
LW858_RS12910	COG2409	Drug exporters of the RND superfamily
LW858_RS12915	COG1309	transcriptional regulator
LW858_RS12930	COG0287	Prephenate dehydrogenase
LW858_RS12945	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LW858_RS12945	COG1605	Chorismate mutase
LW858_RS13005	COG0346	lactoylglutathione lyase activity
LW858_RS13035	COG1879	ABC-type sugar transport system periplasmic component
LW858_RS13040	COG1172	Belongs to the binding-protein-dependent transport system permease family
LW858_RS13045	COG1172	Belongs to the binding-protein-dependent transport system permease family
LW858_RS13055	COG2390	Transcriptional regulator
LW858_RS13060	COG1070	Carbohydrate kinase
LW858_RS13080	COG2329	Antibiotic biosynthesis monooxygenase
LW858_RS13100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LW858_RS13115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LW858_RS13120	COG4187	Peptidase family M20/M25/M40
LW858_RS13125	COG1414	Transcriptional regulator
LW858_RS13130	COG0833	amino acid
LW858_RS13140	COG3239	Fatty acid desaturase
LW858_RS13150	COG2720	vancomycin resistance protein
LW858_RS13155	COG1785	Belongs to the alkaline phosphatase family
LW858_RS13165	COG3655	Transcriptional regulator
LW858_RS13185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS13190	COG0346	lactoylglutathione lyase activity
LW858_RS13210	COG0714	Associated with various cellular activities
LW858_RS13235	COG0463	Glycosyl transferase, family 2
LW858_RS13285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LW858_RS13290	COG0753	catalase activity
LW858_RS13330	COG0714	Associated with various cellular activities
LW858_RS13425	COG0778	Nitroreductase
LW858_RS13430	COG1846	Transcriptional regulator
LW858_RS13450	COG3831	ATPase activity
LW858_RS13450	COG4884	unkown
LW858_RS13460	COG1136	(ABC) transporter
LW858_RS13490	COG0456	acetyltransferase
LW858_RS13510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LW858_RS13540	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LW858_RS13540	COG0456	acetyltransferase
LW858_RS13560	COG0730	response to heat
LW858_RS13570	COG0833	amino acid
LW858_RS13580	COG4335	DNA alkylation repair
LW858_RS13615	COG0768	penicillin binding
LW858_RS13650	COG1984	allophanate hydrolase subunit 2
LW858_RS13655	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LW858_RS13660	COG1414	Transcriptional regulator
LW858_RS13670	COG3142	Participates in the control of copper homeostasis
LW858_RS13675	COG0640	Transcriptional regulator
LW858_RS13685	COG1960	acyl-CoA dehydrogenase activity
LW858_RS13700	COG3314	Sporulation integral membrane protein YlbJ
LW858_RS13720	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LW858_RS13765	COG0415	Belongs to the DNA photolyase family
LW858_RS13780	COG0288	reversible hydration of carbon dioxide
LW858_RS13800	COG4154	Belongs to the RbsD FucU family
LW858_RS13815	COG0798	PFAM Bile acid sodium symporter
LW858_RS13820	COG0346	lactoylglutathione lyase activity
LW858_RS13825	COG0640	Transcriptional regulator
LW858_RS13835	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LW858_RS13840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LW858_RS13840	COG3320	Male sterility
LW858_RS13845	COG1309	transcriptional regulator
LW858_RS13855	COG1522	sequence-specific DNA binding
LW858_RS13870	COG0346	lactoylglutathione lyase activity
LW858_RS13965	COG0745	RESPONSE REGULATOR receiver
LW858_RS13970	COG3850	Histidine kinase
LW858_RS13970	COG5002	protein histidine kinase activity
LW858_RS14025	COG2814	Major facilitator Superfamily
LW858_RS14045	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LW858_RS14060	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LW858_RS14070	COG1136	(ABC) transporter
LW858_RS14075	COG0577	efflux transmembrane transporter activity
LW858_RS14095	COG3850	Histidine kinase
LW858_RS14095	COG5002	protein histidine kinase activity
LW858_RS14105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LW858_RS14130	COG1619	proteins homologs of microcin C7 resistance protein MccF
LW858_RS14150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LW858_RS14170	COG0662	Cupin 2, conserved barrel domain protein
LW858_RS14175	COG2207	Transcriptional regulator
LW858_RS14175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LW858_RS14195	COG3409	Peptidoglycan-binding domain 1 protein
LW858_RS14195	COG5632	N-Acetylmuramoyl-L-alanine amidase
LW858_RS14440	COG4282	regulation of fungal-type cell wall biogenesis
LW858_RS14495	COG1876	peptidase activity
LW858_RS14500	COG2843	Capsule synthesis protein
LW858_RS14510	COG0477	Major facilitator Superfamily
LW858_RS14525	COG1846	Transcriptional regulator
LW858_RS14530	COG2814	Major facilitator Superfamily
LW858_RS14545	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LW858_RS14550	COG1131	(ABC) transporter
LW858_RS14570	COG2076	Multidrug Resistance protein
LW858_RS14575	COG1309	transcriptional regulator
LW858_RS14595	COG2031	fatty acid transporter
LW858_RS14605	COG2249	NAD(P)H dehydrogenase (quinone) activity
LW858_RS14660	COG1288	antiporter activity
LW858_RS14665	COG2356	endonuclease I
LW858_RS14685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LW858_RS14710	COG1733	regulation of RNA biosynthetic process
LW858_RS14715	COG0778	Nitroreductase
LW858_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS14760	COG1131	(ABC) transporter
LW858_RS14785	COG1011	Hydrolase
LW858_RS14795	COG2365	Tyrosine phosphatase family
LW858_RS14835	COG0628	permease
LW858_RS14895	COG1253	flavin adenine dinucleotide binding
LW858_RS14900	COG0789	Transcriptional regulator
LW858_RS14905	COG0697	spore germination
LW858_RS14915	COG1357	PFAM Pentapeptide repeats (8 copies)
LW858_RS14920	COG3813	Protein conserved in bacteria
LW858_RS14925	COG2706	6-phosphogluconolactonase activity
LW858_RS14930	COG1070	Carbohydrate kinase
LW858_RS14945	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LW858_RS14950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LW858_RS14955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LW858_RS14965	COG0604	alcohol dehydrogenase
LW858_RS14970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LW858_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS15010	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LW858_RS15010	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LW858_RS15015	COG1733	regulation of RNA biosynthetic process
LW858_RS15035	COG0656	L-ascorbic acid biosynthetic process
LW858_RS15040	COG2814	Major facilitator Superfamily
LW858_RS15065	COG0814	amino acid
LW858_RS15100	COG1733	regulation of RNA biosynthetic process
LW858_RS15105	COG2188	Transcriptional regulator
LW858_RS15110	COG0673	inositol 2-dehydrogenase activity
LW858_RS15115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LW858_RS15120	COG1733	regulation of RNA biosynthetic process
LW858_RS15125	COG1733	regulation of RNA biosynthetic process
LW858_RS15145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LW858_RS15165	COG0384	phenazine biosynthesis protein PhzF
LW858_RS15175	COG0318	PFAM AMP-dependent synthetase and ligase
LW858_RS15180	COG2249	NAD(P)H dehydrogenase (quinone) activity
LW858_RS15185	COG1733	regulation of RNA biosynthetic process
LW858_RS15210	COG1191	sigma factor activity
LW858_RS15220	COG1280	lysine exporter protein (LysE YggA)
LW858_RS15295	COG1151	hydroxylamine reductase activity
LW858_RS15325	COG2072	flavoprotein involved in K transport
LW858_RS15360	COG1113	amino acid transport
LW858_RS15370	COG2814	Major facilitator Superfamily
LW858_RS15395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LW858_RS15400	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LW858_RS15415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LW858_RS15420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LW858_RS15425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LW858_RS15430	COG3739	integral membrane protein
LW858_RS15450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS15465	COG0583	DNA-binding transcription factor activity
LW858_RS15485	COG1193	negative regulation of DNA recombination
LW858_RS15500	COG2162	N-hydroxyarylamine O-acetyltransferase activity
LW858_RS15505	COG1164	Oligoendopeptidase f
LW858_RS15530	COG3781	membrane
LW858_RS15545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LW858_RS15570	COG0584	glycerophosphoryl diester phosphodiesterase
LW858_RS15580	COG0640	Transcriptional regulator
LW858_RS15585	COG0604	alcohol dehydrogenase
LW858_RS15595	COG0457	Tetratricopeptide repeat
LW858_RS15605	COG2808	Putative FMN-binding domain
LW858_RS15610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LW858_RS15625	COG0277	FAD linked oxidase domain protein
LW858_RS15675	COG1285	pathogenesis
LW858_RS15685	COG2514	catechol 2,3-dioxygenase activity
LW858_RS15690	COG2720	vancomycin resistance protein
LW858_RS15855	COG3547	Transposase (IS116 IS110 IS902 family)
LW858_RS15875	COG0270	DNA (cytosine-5-)-methyltransferase activity
LW858_RS15900	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LW858_RS15920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LW858_RS15950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LW858_RS15950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LW858_RS16010	COG1484	DNA-dependent DNA replication
LW858_RS16040	COG0582	viral genome integration into host DNA
LW858_RS16070	COG0716	FMN binding
LW858_RS16080	COG0494	nUDIX hydrolase
LW858_RS16100	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS16110	COG0165	Argininosuccinate lyase
LW858_RS16125	COG4145	pantothenate transmembrane transporter activity
LW858_RS16135	COG1012	belongs to the aldehyde dehydrogenase family
LW858_RS16140	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS16150	COG1657	PFAM Prenyltransferase squalene oxidase
LW858_RS16155	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
LW858_RS16160	COG2962	Rard protein
LW858_RS16165	COG3326	Membrane
LW858_RS16180	COG0489	protein tyrosine kinase activity
LW858_RS16190	COG0314	molybdopterin synthase activity
LW858_RS16195	COG0303	'Molybdopterin
LW858_RS16200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LW858_RS16205	COG2116	formate transmembrane transporter activity
LW858_RS16215	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LW858_RS16220	COG5609	conserved protein (DUF2294)
LW858_RS16225	COG2427	Protein of unknown function (DUF1641)
LW858_RS16230	COG3383	formate dehydrogenase (NAD+) activity
LW858_RS16235	COG0697	spore germination
LW858_RS16250	COG0531	amino acid
LW858_RS16285	COG2226	methyltransferase
LW858_RS16290	COG4166	transmembrane transport
LW858_RS16295	COG4166	transmembrane transport
LW858_RS16300	COG4166	transmembrane transport
LW858_RS16305	COG1301	dicarboxylic acid transport
LW858_RS16310	COG1316	TRANSCRIPTIONal
LW858_RS16320	COG1595	DNA-templated transcription, initiation
LW858_RS16330	COG1131	(ABC) transporter
LW858_RS16350	COG0673	inositol 2-dehydrogenase activity
LW858_RS16355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LW858_RS16360	COG0187	DNA topoisomerase II activity
LW858_RS16365	COG1832	CoA-binding protein
LW858_RS16370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LW858_RS16375	COG0745	RESPONSE REGULATOR receiver
LW858_RS16395	COG4841	protein insertion into membrane
LW858_RS16400	COG0824	Thioesterase
LW858_RS16425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LW858_RS16445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LW858_RS16475	COG2211	Major facilitator Superfamily
LW858_RS16485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LW858_RS16500	COG0183	Belongs to the thiolase family
LW858_RS16505	COG0318	PFAM AMP-dependent synthetase and ligase
LW858_RS16510	COG1268	BioY protein
LW858_RS16515	COG0318	PFAM AMP-dependent synthetase and ligase
LW858_RS16520	COG1396	sequence-specific DNA binding
LW858_RS16525	COG3547	Transposase (IS116 IS110 IS902 family)
LW858_RS16555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LW858_RS16565	COG5002	protein histidine kinase activity
LW858_RS16570	COG0400	carboxylic ester hydrolase activity
LW858_RS16575	COG0346	lactoylglutathione lyase activity
LW858_RS16580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LW858_RS16590	COG0069	glutamate synthase activity
LW858_RS16595	COG1902	pentaerythritol trinitrate reductase activity
LW858_RS16600	COG1329	Transcriptional regulator
LW858_RS16610	COG0010	Belongs to the arginase family
LW858_RS16660	COG4846	Membrane protein involved in cytochrome C biogenesis
LW858_RS16665	COG0785	Cytochrome C biogenesis protein
LW858_RS16675	COG1473	amidohydrolase
LW858_RS16685	COG1131	(ABC) transporter
LW858_RS16700	COG0583	DNA-binding transcription factor activity
LW858_RS16710	COG1346	cytolysis
LW858_RS16730	COG0730	response to heat
LW858_RS16755	COG1132	(ABC) transporter
LW858_RS16760	COG1132	(ABC) transporter
LW858_RS16805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LW858_RS16810	COG0737	Belongs to the 5'-nucleotidase family
LW858_RS16820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LW858_RS16840	COG1695	Transcriptional regulator
LW858_RS16850	COG5632	N-Acetylmuramoyl-L-alanine amidase
LW858_RS16850	COG3409	Peptidoglycan-binding domain 1 protein
LW858_RS16850	COG1388	LysM domain
LW858_RS16855	COG0739	heme binding
LW858_RS16860	COG0741	lytic transglycosylase activity
LW858_RS16895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LW858_RS16900	COG0174	glutamine synthetase
LW858_RS16905	COG0789	Transcriptional regulator
LW858_RS16910	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LW858_RS16915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LW858_RS16920	COG2860	membrane
LW858_RS16930	COG0464	growth
LW858_RS16965	COG1388	LysM domain
LW858_RS16965	COG3584	3D domain protein
LW858_RS16970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LW858_RS16970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LW858_RS16970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LW858_RS16975	COG1105	Belongs to the carbohydrate kinase PfkB family
LW858_RS16980	COG1349	DNA-binding transcription factor activity
LW858_RS16985	COG1979	alcohol dehydrogenase
LW858_RS16990	COG2322	membrane
LW858_RS17000	COG1113	amino acid transport
LW858_RS17010	COG1408	metallophosphoesterase
LW858_RS17015	COG2116	formate transmembrane transporter activity
LW858_RS17035	COG2217	Heavy metal translocating P-type atpase
LW858_RS17040	COG2608	mercury ion transmembrane transporter activity
LW858_RS17045	COG1937	Protein conserved in bacteria
LW858_RS17055	COG2819	hydrolase of the alpha beta superfamily
LW858_RS17060	COG1120	ATPase activity
LW858_RS17065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LW858_RS17070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LW858_RS17075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LW858_RS17080	COG0708	Exodeoxyribonuclease III
LW858_RS17085	COG2169	Transcriptional regulator
LW858_RS17090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LW858_RS17095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LW858_RS17115	COG2267	carboxylic ester hydrolase activity
LW858_RS17120	COG3300	MHYT domain
LW858_RS17120	COG5001	Diguanylate cyclase
LW858_RS17145	COG1086	Polysaccharide biosynthesis protein
LW858_RS17165	COG1346	cytolysis
LW858_RS17175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LW858_RS17185	COG2188	Transcriptional regulator
LW858_RS17190	COG2723	6-phospho-beta-galactosidase activity
LW858_RS17215	COG3773	Cell wall hydrolase
LW858_RS17225	COG1368	sulfuric ester hydrolase activity
LW858_RS17230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LW858_RS17255	COG4550	Control of competence regulator ComK, YlbF/YmcA
LW858_RS17265	COG1013	pyruvate-flavodoxin oxidoreductase activity
LW858_RS17270	COG0674	pyruvate-flavodoxin oxidoreductase activity
LW858_RS17270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LW858_RS17280	COG2359	stage V sporulation protein S
LW858_RS17285	COG1692	metallophosphoesterase
LW858_RS17305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LW858_RS17310	COG1426	Protein conserved in bacteria
LW858_RS17325	COG0300	oxidoreductase activity
LW858_RS17330	COG0612	Peptidase, M16
LW858_RS17335	COG0612	Peptidase, M16
LW858_RS17340	COG1079	Belongs to the binding-protein-dependent transport system permease family
LW858_RS17345	COG4603	Belongs to the binding-protein-dependent transport system permease family
LW858_RS17350	COG3845	ABC transporter
LW858_RS17355	COG1744	ABC transporter substrate-binding protein PnrA-like
LW858_RS17360	COG2188	Transcriptional regulator
LW858_RS17375	COG0740	serine-type endopeptidase activity
LW858_RS17385	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LW858_RS17395	COG0527	aspartate kinase activity
LW858_RS17400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LW858_RS17405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LW858_RS17410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LW858_RS17415	COG1873	PFAM PRC-barrel domain
LW858_RS17420	COG0612	Peptidase, M16
LW858_RS17425	COG0726	polysaccharide deacetylase
LW858_RS17440	COG0196	riboflavin kinase activity
LW858_RS17450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LW858_RS17455	COG1550	Protein conserved in bacteria
LW858_RS17465	COG1358	cellular component organization or biogenesis
LW858_RS17470	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LW858_RS17475	COG0195	Participates in both transcription termination and antitermination
LW858_RS17495	COG0750	zinc metalloprotease
LW858_RS17505	COG4589	Belongs to the CDS family
LW858_RS17550	COG4974	Belongs to the 'phage' integrase family
LW858_RS17560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LW858_RS17565	COG0758	DNA mediated transformation
LW858_RS17570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LW858_RS17610	COG1837	Belongs to the UPF0109 family
LW858_RS17620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LW858_RS17630	COG0552	protein localization to endoplasmic reticulum
LW858_RS17635	COG1196	nuclear chromosome segregation
LW858_RS17645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LW858_RS17650	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS17655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LW858_RS17670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LW858_RS17675	COG1461	Dihydroxyacetone kinase
LW858_RS17680	COG1302	Protein conserved in bacteria
LW858_RS17695	COG1564	THIamine pyrophosphokinase
LW858_RS17700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LW858_RS17710	COG0515	serine threonine protein kinase
LW858_RS17710	COG2815	serine threonine protein kinase
LW858_RS17715	COG0631	protein serine/threonine phosphatase activity
LW858_RS17725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LW858_RS17725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LW858_RS17740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LW858_RS17745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LW858_RS17765	COG1561	YicC-like family, N-terminal region
LW858_RS17770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LW858_RS17780	COG0006	proline dipeptidase activity
LW858_RS17790	COG3069	C4-dicarboxylate transmembrane transporter activity
LW858_RS17855	COG0564	pseudouridine synthase activity
LW858_RS17875	COG3599	regulation of cell shape
LW858_RS17880	COG2302	S4 RNA-binding domain
LW858_RS17885	COG0762	integral membrane protein
LW858_RS17895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LW858_RS17905	COG1873	PFAM PRC-barrel domain
LW858_RS17910	COG1191	sigma factor activity
LW858_RS17915	COG1191	sigma factor activity
LW858_RS17925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LW858_RS17930	COG0849	cell division
LW858_RS17950	COG0772	Belongs to the SEDS family
LW858_RS17970	COG0768	penicillin binding
LW858_RS17975	COG0768	penicillin binding
LW858_RS17995	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LW858_RS18015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LW858_RS18020	COG1399	metal-binding, possibly nucleic acid-binding protein
LW858_RS18030	COG3480	Lon protease (S16) C-terminal proteolytic domain
LW858_RS18035	COG1752	Esterase of the alpha-beta hydrolase superfamily
LW858_RS18040	COG3314	Sporulation integral membrane protein YlbJ
LW858_RS18050	COG0742	ribosomal rna small subunit methyltransferase
LW858_RS18065	COG3679	Belongs to the UPF0342 family
LW858_RS18070	COG0406	alpha-ribazole phosphatase activity
LW858_RS18085	COG2340	Cysteine-rich secretory protein family
LW858_RS18100	COG3336	cytochrome c oxidase
LW858_RS18140	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LW858_RS18145	COG0772	Belongs to the SEDS family
LW858_RS18155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LW858_RS18165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LW858_RS18175	COG4896	Protein conserved in bacteria
LW858_RS18190	COG1217	gtp-binding protein TYPA
LW858_RS18200	COG0483	inositol monophosphate 1-phosphatase activity
LW858_RS18220	COG1982	Orn Lys Arg decarboxylase major
LW858_RS18270	COG0022	dehydrogenase e1 component
LW858_RS18275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LW858_RS18295	COG0561	phosphatase activity
LW858_RS18305	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LW858_RS18310	COG0569	domain protein
LW858_RS18330	COG0583	DNA-binding transcription factor activity
LW858_RS18335	COG0517	IMP dehydrogenase activity
LW858_RS18345	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
LW858_RS18355	COG4703	Protein of unknown function (DUF1797)
LW858_RS18375	COG2200	EAL domain
LW858_RS18380	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS18385	COG1408	metallophosphoesterase
LW858_RS18435	COG2814	Major facilitator Superfamily
LW858_RS18455	COG3209	COG3209 Rhs family protein
LW858_RS18465	COG2205	protein histidine kinase activity
LW858_RS18475	COG0436	Aminotransferase
LW858_RS18485	COG1609	Transcriptional regulator
LW858_RS18490	COG3833	ABC-type maltose transport systems, permease component
LW858_RS18495	COG1175	transmembrane transport
LW858_RS18500	COG2182	Extracellular solute-binding protein
LW858_RS18510	COG0366	Alpha amylase catalytic
LW858_RS18515	COG3842	ATPase activity
LW858_RS18565	COG0183	Belongs to the thiolase family
LW858_RS18600	COG1695	Transcriptional regulator
LW858_RS18605	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS18625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LW858_RS18630	COG0436	Aminotransferase
LW858_RS18670	COG2084	Dehydrogenase
LW858_RS18680	COG2199	diguanylate cyclase activity
LW858_RS18685	COG0778	Nitroreductase
LW858_RS18710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LW858_RS18710	COG1263	PTS System
LW858_RS18710	COG2190	(PTS) system
LW858_RS18715	COG3711	transcriptional antiterminator
LW858_RS18725	COG2188	Transcriptional regulator
LW858_RS18740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LW858_RS18765	COG1547	Domain of unknown function (DUF309)
LW858_RS18770	COG0456	acetyltransferase
LW858_RS18780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LW858_RS18785	COG4086	secreted protein
LW858_RS18790	COG0561	phosphatase activity
LW858_RS18795	COG0697	spore germination
LW858_RS18810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LW858_RS18835	COG0733	neurotransmitter:sodium symporter activity
LW858_RS18855	COG1686	Belongs to the peptidase S11 family
LW858_RS18860	COG1725	Transcriptional regulator
LW858_RS18865	COG1131	(ABC) transporter
LW858_RS18890	COG1846	Transcriptional regulator
LW858_RS18905	COG0598	Magnesium transport protein CorA
LW858_RS18935	COG4974	Belongs to the 'phage' integrase family
LW858_RS18945	COG0735	belongs to the Fur family
LW858_RS18950	COG1300	Membrane
LW858_RS18975	COG0667	Aldo Keto reductase
LW858_RS18980	COG0656	L-ascorbic acid biosynthetic process
LW858_RS18995	COG4085	toxin activity
LW858_RS18995	COG1525	nuclease
LW858_RS18995	COG0737	Belongs to the 5'-nucleotidase family
LW858_RS19005	COG0596	Alpha beta hydrolase
LW858_RS19010	COG2056	Na+-H+ antiporter family
LW858_RS19020	COG1609	Transcriptional regulator
LW858_RS19025	COG0456	acetyltransferase
LW858_RS19030	COG1073	alpha beta
LW858_RS19045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LW858_RS19045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LW858_RS19050	COG0307	riboflavin synthase, alpha
LW858_RS19080	COG1073	alpha beta
LW858_RS19080	COG2226	methyltransferase
LW858_RS19095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LW858_RS19105	COG1757	Na H antiporter
LW858_RS19110	COG0737	Belongs to the 5'-nucleotidase family
LW858_RS19120	COG1522	sequence-specific DNA binding
LW858_RS19165	COG0300	oxidoreductase activity
LW858_RS19170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LW858_RS19175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LW858_RS19180	COG1760	l-serine dehydratase
LW858_RS19185	COG1760	l-serine dehydratase
LW858_RS19205	COG2195	Cleaves the N-terminal amino acid of tripeptides
LW858_RS19210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS19225	COG1376	ErfK ybiS ycfS ynhG family protein
LW858_RS19230	COG4129	membrane
LW858_RS19235	COG1126	abc transporter atp-binding protein
LW858_RS19240	COG0765	amino acid transport
LW858_RS19245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LW858_RS19265	COG2323	membrane
LW858_RS19270	COG0772	Belongs to the SEDS family
LW858_RS19280	COG0508	dehydrogenase complex catalyzes the overall conversion of
LW858_RS19285	COG0022	dehydrogenase e1 component
LW858_RS19290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LW858_RS19295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LW858_RS19310	COG0280	phosphate acetyltransferase
LW858_RS19315	COG3829	transcription factor binding
LW858_RS19315	COG3290	protein histidine kinase activity
LW858_RS19325	COG0584	glycerophosphoryl diester phosphodiesterase
LW858_RS19330	COG3093	addiction module antidote protein HigA
LW858_RS19345	COG0750	zinc metalloprotease
LW858_RS19350	COG0497	DNA recombination
LW858_RS19360	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LW858_RS19370	COG0142	geranyltranstransferase activity
LW858_RS19395	COG1302	Protein conserved in bacteria
LW858_RS19400	COG0439	Biotin carboxylase
LW858_RS19405	COG0511	ligase activity, forming carbon-carbon bonds
LW858_RS19450	COG3854	ATPases associated with a variety of cellular activities
LW858_RS19500	COG3872	metal-dependent enzyme
LW858_RS19510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LW858_RS19545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LW858_RS19555	COG1609	Transcriptional regulator
LW858_RS19565	COG2076	Multidrug Resistance protein
LW858_RS19570	COG2076	Multidrug Resistance protein
LW858_RS19610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LW858_RS19645	COG2169	Transcriptional regulator
LW858_RS19650	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LW858_RS19680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LW858_RS19685	COG2169	Transcriptional regulator
LW858_RS19705	COG2264	protein methyltransferase activity
LW858_RS19755	COG1459	type II secretion system
LW858_RS19760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LW858_RS19815	COG1410	methionine synthase
LW858_RS19815	COG0646	methionine synthase
LW858_RS19820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LW858_RS19820	COG0646	methionine synthase
LW858_RS19825	COG0626	cystathionine gamma-synthase activity
LW858_RS19830	COG0626	cystathionine gamma-synthase activity
LW858_RS19855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LW858_RS19865	COG1940	carbohydrate kinase activity
LW858_RS19870	COG4483	Protein conserved in bacteria
LW858_RS19875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LW858_RS19880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LW858_RS19885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LW858_RS19890	COG0704	Plays a role in the regulation of phosphate uptake
LW858_RS19900	COG0573	inorganic phosphate transmembrane transporter activity
LW858_RS19905	COG0573	inorganic phosphate transmembrane transporter activity
LW858_RS19910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LW858_RS19915	COG0768	penicillin binding
LW858_RS19920	COG0477	Major facilitator Superfamily
LW858_RS19925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LW858_RS19935	COG5521	maltodextrose utilization protein MalA
LW858_RS19950	COG0735	belongs to the Fur family
LW858_RS19955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LW858_RS19960	COG1121	(ABC) transporter
LW858_RS19965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LW858_RS19995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LW858_RS20000	COG2384	SAM-dependent methyltransferase
LW858_RS20010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LW858_RS20015	COG0358	DNA primase activity
LW858_RS20030	COG0517	IMP dehydrogenase activity
LW858_RS20045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LW858_RS20050	COG0295	cytidine deaminase activity
LW858_RS20055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LW858_RS20065	COG1480	7TM receptor with intracellular HD hydrolase
LW858_RS20070	COG1702	phosphate starvation-inducible protein PhoH
LW858_RS20085	COG1610	YqeY-like protein
LW858_RS20090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LW858_RS20095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LW858_RS20100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LW858_RS20125	COG3547	Transposase (IS116 IS110 IS902 family)
LW858_RS20135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LW858_RS20140	COG1733	regulation of RNA biosynthetic process
LW858_RS20165	COG1466	dna polymerase III delta subunit
LW858_RS20175	COG0658	competence protein
LW858_RS20175	COG2333	competence protein COMEC
LW858_RS20180	COG2131	deaminase
LW858_RS20185	COG1555	photosystem II stabilization
LW858_RS20185	COG1596	polysaccharide export
LW858_RS20190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LW858_RS20195	COG2226	methyltransferase
LW858_RS20200	COG0799	negative regulation of ribosome biogenesis
LW858_RS20205	COG1713	HD superfamily hydrolase involved in NAD metabolism
LW858_RS20215	COG1534	Rna-binding protein
LW858_RS20225	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LW858_RS20230	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LW858_RS20270	COG0778	Nitroreductase
LW858_RS20275	COG2357	RelA SpoT domain protein
LW858_RS20295	COG2267	carboxylic ester hydrolase activity
LW858_RS20345	COG3186	Phenylalanine-4-hydroxylase
LW858_RS20360	COG2514	catechol 2,3-dioxygenase activity
LW858_RS20365	COG2259	Doxx family
LW858_RS20410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LW858_RS20420	COG1012	belongs to the aldehyde dehydrogenase family
LW858_RS20420	COG1454	alcohol dehydrogenase
LW858_RS20425	COG0626	cystathionine gamma-synthase activity
LW858_RS20430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LW858_RS20460	COG0768	penicillin binding
LW858_RS20485	COG0826	peptidase U32
LW858_RS20490	COG0826	peptidase U32
LW858_RS20495	COG4122	O-methyltransferase activity
LW858_RS20500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LW858_RS20530	COG0628	permease
LW858_RS20550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LW858_RS20565	COG1104	cysteine desulfurase activity
LW858_RS20570	COG1959	2 iron, 2 sulfur cluster binding
LW858_RS20575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LW858_RS20590	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LW858_RS20620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LW858_RS20630	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LW858_RS20630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LW858_RS20635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LW858_RS20640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LW858_RS20640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LW858_RS20650	COG2244	polysaccharide biosynthetic process
LW858_RS20655	COG2323	membrane
LW858_RS20665	COG1862	Preprotein translocase
LW858_RS20695	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LW858_RS20730	COG0157	Belongs to the NadC ModD family
LW858_RS20735	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LW858_RS20740	COG1104	cysteine desulfurase activity
LW858_RS20745	COG1827	regulation of RNA biosynthetic process
LW858_RS20750	COG2258	MOSC domain
LW858_RS20755	COG0077	Prephenate dehydratase
LW858_RS20760	COG0577	efflux transmembrane transporter activity
LW858_RS20765	COG0577	efflux transmembrane transporter activity
LW858_RS20770	COG1136	(ABC) transporter
LW858_RS20775	COG5002	protein histidine kinase activity
LW858_RS20780	COG0745	RESPONSE REGULATOR receiver
LW858_RS20790	COG3290	protein histidine kinase activity
LW858_RS20800	COG2868	ribosomal protein
LW858_RS20810	COG1530	ribonuclease E activity
LW858_RS20815	COG1994	Peptidase M50
LW858_RS20820	COG0739	heme binding
LW858_RS20825	COG2894	cell division
LW858_RS20845	COG1077	Cell shape determining protein MreB Mrl
LW858_RS20880	COG0457	Tetratricopeptide repeat
LW858_RS20950	COG3646	Phage regulatory protein
LW858_RS20970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LW858_RS20990	COG0285	dihydrofolate synthase activity
LW858_RS21005	COG1388	LysM domain
LW858_RS21015	COG0113	porphobilinogen synthase activity
LW858_RS21020	COG1587	Uroporphyrinogen-III synthase
LW858_RS21030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LW858_RS21040	COG1846	Transcriptional regulator
LW858_RS21045	COG1764	response to oxidative stress
LW858_RS21060	COG1067	ATP-dependent peptidase activity
LW858_RS21060	COG0470	DNA polymerase III
LW858_RS21105	COG0622	Phosphoesterase
LW858_RS21120	COG5401	PFAM Sporulation and spore germination
LW858_RS21140	COG1309	transcriptional regulator
LW858_RS21150	COG2197	response regulator
LW858_RS21170	COG0402	S-adenosylhomocysteine deaminase activity
LW858_RS21175	COG1983	PspC domain protein
LW858_RS21180	COG1396	sequence-specific DNA binding
LW858_RS21185	COG0697	spore germination
LW858_RS21195	COG1959	2 iron, 2 sulfur cluster binding
LW858_RS21200	COG1668	transmembrane transport
LW858_RS21205	COG4152	abc transporter atp-binding protein
LW858_RS21210	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LW858_RS21220	COG1360	Flagellar Motor Protein
LW858_RS21225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LW858_RS21230	COG1876	peptidase activity
LW858_RS21235	COG0824	Thioesterase
LW858_RS21240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LW858_RS21245	COG1053	succinate dehydrogenase
LW858_RS21250	COG2009	succinate dehydrogenase
LW858_RS21255	COG1719	4-vinyl reductase, 4VR
LW858_RS21270	COG3118	belongs to the thioredoxin family
LW858_RS21275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LW858_RS21280	COG2086	electron transfer activity
LW858_RS21285	COG1024	Enoyl-CoA hydratase
LW858_RS21290	COG1309	transcriptional regulator
LW858_RS21295	COG0318	PFAM AMP-dependent synthetase and ligase
LW858_RS21320	COG2318	DinB family
LW858_RS21350	COG2205	protein histidine kinase activity
LW858_RS21355	COG0745	RESPONSE REGULATOR receiver
LW858_RS21365	COG4895	conserved protein (DUF2196)
LW858_RS21370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LW858_RS21380	COG4509	Sortase family
LW858_RS21385	COG1120	ATPase activity
LW858_RS21400	COG5386	Cell surface protein
LW858_RS21410	COG5386	Cell surface protein
LW858_RS21415	COG1114	Component of the transport system for branched-chain amino acids
LW858_RS21420	COG1187	pseudouridine synthase activity
LW858_RS21430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LW858_RS21430	COG1796	DNA polymerase
LW858_RS21435	COG1286	toxin biosynthetic process
LW858_RS21480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LW858_RS21490	COG1418	mRNA catabolic process
LW858_RS21510	COG2814	Major facilitator Superfamily
LW858_RS21515	COG1566	PFAM secretion protein HlyD family protein
LW858_RS21520	COG1309	transcriptional regulator
LW858_RS21525	COG1363	Peptidase, m42
LW858_RS21550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LW858_RS21565	COG1484	DNA-dependent DNA replication
LW858_RS21570	COG3611	Membrane attachment protein
LW858_RS21580	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LW858_RS21585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LW858_RS21595	COG1971	Probably functions as a manganese efflux pump
LW858_RS21605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LW858_RS21605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LW858_RS21610	COG5002	protein histidine kinase activity
LW858_RS21615	COG0745	RESPONSE REGULATOR receiver
LW858_RS21635	COG0538	isocitrate dehydrogenase activity
LW858_RS21640	COG0372	Belongs to the citrate synthase family
LW858_RS21650	COG0628	permease
LW858_RS21655	COG3030	protein affecting phage T7 exclusion by the F plasmid
LW858_RS21680	COG1725	Transcriptional regulator
LW858_RS21685	COG0281	malic enzyme
LW858_RS21690	COG0587	DNA-directed DNA polymerase activity
LW858_RS21705	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LW858_RS21720	COG4109	DRTGG domain
LW858_RS21735	COG0006	proline dipeptidase activity
LW858_RS21770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS21775	COG0662	Cupin 2, conserved barrel domain protein
LW858_RS21790	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS21795	COG0589	response to stress
LW858_RS21835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LW858_RS21860	COG0827	DNA restriction-modification system
LW858_RS21865	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LW858_RS21870	COG3874	Sporulation protein YtfJ
LW858_RS21885	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LW858_RS21895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LW858_RS21910	COG1104	cysteine desulfurase activity
LW858_RS21925	COG0583	DNA-binding transcription factor activity
LW858_RS21930	COG0697	spore germination
LW858_RS21935	COG1309	transcriptional regulator
LW858_RS21940	COG1956	GAF domain-containing protein
LW858_RS21945	COG0626	cystathionine gamma-synthase activity
LW858_RS21980	COG0110	maltose O-acetyltransferase activity
LW858_RS21985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LW858_RS21990	COG0454	-acetyltransferase
LW858_RS21995	COG0517	IMP dehydrogenase activity
LW858_RS22000	COG0123	including yeast histone deacetylase and acetoin utilization protein
LW858_RS22020	COG0745	RESPONSE REGULATOR receiver
LW858_RS22030	COG0666	response to abiotic stimulus
LW858_RS22065	COG1609	Transcriptional regulator
LW858_RS22085	COG4851	CamS sex pheromone cAM373 precursor
LW858_RS22090	COG3118	belongs to the thioredoxin family
LW858_RS22100	COG2309	aminopeptidase activity
LW858_RS22125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS22145	COG1674	ftsk spoiiie
LW858_RS22165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LW858_RS22175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LW858_RS22180	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LW858_RS22185	COG1363	Peptidase, m42
LW858_RS22200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LW858_RS22215	COG0510	thiamine kinase activity
LW858_RS22220	COG1523	belongs to the glycosyl hydrolase 13 family
LW858_RS22230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LW858_RS22240	COG1349	DNA-binding transcription factor activity
LW858_RS22245	COG1187	pseudouridine synthase activity
LW858_RS22250	COG2244	polysaccharide biosynthetic process
LW858_RS22255	COG2081	HI0933 family
LW858_RS22260	COG2814	Major facilitator Superfamily
LW858_RS22270	COG3832	glyoxalase III activity
LW858_RS22290	COG1329	Transcriptional regulator
LW858_RS22315	COG0314	molybdopterin synthase activity
LW858_RS22320	COG1763	Mo-molybdopterin cofactor biosynthetic process
LW858_RS22325	COG0303	'Molybdopterin
LW858_RS22335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LW858_RS22340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LW858_RS22360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LW858_RS22370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LW858_RS22410	COG2814	Major facilitator Superfamily
LW858_RS22415	COG0475	glutathione-regulated potassium exporter activity
LW858_RS22420	COG0490	domain, Protein
LW858_RS22425	COG0582	viral genome integration into host DNA
LW858_RS22445	COG1136	(ABC) transporter
LW858_RS22465	COG1242	4 iron, 4 sulfur cluster binding
LW858_RS22470	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LW858_RS22485	COG1794	racemase activity, acting on amino acids and derivatives
LW858_RS22505	COG2267	carboxylic ester hydrolase activity
LW858_RS22510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LW858_RS22515	COG0671	phosphoesterase, PA-phosphatase related
LW858_RS22520	COG0438	transferase activity, transferring glycosyl groups
LW858_RS22540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS22625	COG5002	protein histidine kinase activity
LW858_RS22630	COG3852	Histidine kinase
LW858_RS22635	COG0753	catalase activity
LW858_RS22645	COG2267	carboxylic ester hydrolase activity
LW858_RS22650	COG1368	sulfuric ester hydrolase activity
LW858_RS22665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LW858_RS22670	COG1116	anion transmembrane transporter activity
LW858_RS22675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LW858_RS22700	COG0494	nUDIX hydrolase
LW858_RS22730	COG1854	S-ribosylhomocysteine lyase activity
LW858_RS22740	COG0288	reversible hydration of carbon dioxide
LW858_RS22745	COG1271	oxidase subunit
LW858_RS22750	COG1294	oxidase, subunit
LW858_RS22770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LW858_RS22790	COG1842	Phage shock protein A
LW858_RS22820	COG5002	protein histidine kinase activity
LW858_RS22825	COG0745	RESPONSE REGULATOR receiver
LW858_RS22850	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LW858_RS22855	COG1597	lipid kinase activity
LW858_RS22880	COG0577	efflux transmembrane transporter activity
LW858_RS22885	COG1136	(ABC) transporter
LW858_RS22900	COG0586	Pfam SNARE associated Golgi protein
LW858_RS22910	COG0577	efflux transmembrane transporter activity
LW858_RS22915	COG1136	(ABC) transporter
LW858_RS22920	COG3708	Transcriptional regulator
LW858_RS22920	COG2207	Transcriptional regulator
LW858_RS22930	COG5658	integral membrane protein
LW858_RS22935	COG0640	Transcriptional regulator
LW858_RS22940	COG0745	RESPONSE REGULATOR receiver
LW858_RS22945	COG2205	protein histidine kinase activity
LW858_RS22950	COG0577	efflux transmembrane transporter activity
LW858_RS22955	COG0577	efflux transmembrane transporter activity
LW858_RS22960	COG1136	(ABC) transporter
LW858_RS22965	COG0577	efflux transmembrane transporter activity
LW858_RS22990	COG2188	Transcriptional regulator
LW858_RS23010	COG3964	amidohydrolase
LW858_RS23030	COG4948	Mandelate Racemase Muconate Lactonizing
LW858_RS23040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LW858_RS23045	COG0596	Alpha beta hydrolase
LW858_RS23055	COG1169	isochorismate synthase
LW858_RS23060	COG1575	Belongs to the MenA family. Type 1 subfamily
LW858_RS23065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LW858_RS23095	COG0058	SHG alpha-glucan phosphorylase activity
LW858_RS23105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LW858_RS23125	COG1404	Belongs to the peptidase S8 family
LW858_RS23265	COG1285	pathogenesis
LW858_RS23270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LW858_RS23285	COG2155	Conserved Protein
LW858_RS23290	COG1098	S1 RNA binding domain
LW858_RS23295	COG0436	Aminotransferase
LW858_RS23300	COG1522	sequence-specific DNA binding
LW858_RS23305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LW858_RS23310	COG2267	carboxylic ester hydrolase activity
LW858_RS23320	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LW858_RS23340	COG5018	Exonuclease
LW858_RS23345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LW858_RS23365	COG2050	protein possibly involved in aromatic compounds catabolism
LW858_RS23375	COG1268	BioY protein
LW858_RS23380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LW858_RS23385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LW858_RS23405	COG2076	Multidrug Resistance protein
LW858_RS23410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LW858_RS23430	COG3584	3D domain protein
LW858_RS23445	COG1252	NADH dehydrogenase
LW858_RS23460	COG3708	Transcriptional regulator
LW858_RS23475	COG1683	Conserved Protein
LW858_RS23505	COG0316	Belongs to the HesB IscA family
LW858_RS23520	COG1252	NADH dehydrogenase
LW858_RS23535	COG0390	transport system, permease component
LW858_RS23540	COG2824	Alkylphosphonate utilization operon protein PhnA
LW858_RS23585	COG4837	Protein of unknown function (DUF1462)
LW858_RS23590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LW858_RS23600	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LW858_RS23605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LW858_RS23615	COG2249	NAD(P)H dehydrogenase (quinone) activity
LW858_RS23625	COG0647	UMP catabolic process
LW858_RS23635	COG2445	Protein of unknown function DUF86
LW858_RS23640	COG1494	fructose-1,6-bisphosphatase
LW858_RS23680	COG4470	Protein conserved in bacteria
LW858_RS23690	COG0789	Transcriptional regulator
LW858_RS23695	COG4377	Putative membrane peptidase family (DUF2324)
LW858_RS23720	COG0739	heme binding
LW858_RS23730	COG3377	Domain of unknown function (DUF1805)
LW858_RS23735	COG0737	Belongs to the 5'-nucleotidase family
LW858_RS23740	COG0719	Fe-S assembly protein
LW858_RS23745	COG0822	iron-sulfur transferase activity
LW858_RS23750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LW858_RS23755	COG0719	Fe-S assembly protein
LW858_RS23760	COG0396	ATPase activity
LW858_RS23765	COG1464	Belongs to the NlpA lipoprotein family
LW858_RS23770	COG1464	Belongs to the NlpA lipoprotein family
LW858_RS23775	COG2011	ABC-type metal ion transport system permease component
LW858_RS23790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LW858_RS23795	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LW858_RS23805	COG1393	Belongs to the ArsC family
LW858_RS23860	COG1309	transcriptional regulator
LW858_RS23865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LW858_RS23870	COG1960	acyl-CoA dehydrogenase activity
LW858_RS23875	COG0183	Belongs to the thiolase family
LW858_RS23880	COG1024	Enoyl-CoA hydratase
LW858_RS23880	COG1250	3-hydroxyacyl-CoA dehydrogenase
LW858_RS23890	COG1686	Belongs to the peptidase S11 family
LW858_RS23905	COG0011	TIGRFAM Protein of
LW858_RS23910	COG0840	transmembrane signaling receptor activity
LW858_RS23925	COG2814	Major facilitator Superfamily
LW858_RS23930	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
LW858_RS23950	COG0531	amino acid
LW858_RS23980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LW858_RS24015	COG0586	Pfam SNARE associated Golgi protein
LW858_RS24025	COG1376	ErfK ybiS ycfS ynhG family protein
LW858_RS24030	COG0745	RESPONSE REGULATOR receiver
LW858_RS24035	COG5002	protein histidine kinase activity
LW858_RS24075	COG0840	transmembrane signaling receptor activity
LW858_RS24080	COG2151	metal-sulfur cluster biosynthetic enzyme
LW858_RS24085	COG3227	Zinc metalloprotease (Elastase)
LW858_RS24090	COG1741	Belongs to the pirin family
LW858_RS24105	COG0586	Pfam SNARE associated Golgi protein
LW858_RS24110	COG0475	glutathione-regulated potassium exporter activity
LW858_RS24115	COG0490	domain, Protein
LW858_RS24120	COG1115	amino acid carrier protein
LW858_RS24125	COG0783	Belongs to the Dps family
LW858_RS24140	COG1611	Belongs to the LOG family
LW858_RS24150	COG1528	Iron-storage protein
LW858_RS24160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LW858_RS24165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LW858_RS24170	COG1115	amino acid carrier protein
LW858_RS24175	COG1115	amino acid carrier protein
LW858_RS24180	COG2910	NAD(P)H-binding
LW858_RS24200	COG0656	L-ascorbic acid biosynthetic process
LW858_RS24205	COG2814	Major facilitator Superfamily
LW858_RS24210	COG1733	regulation of RNA biosynthetic process
LW858_RS24220	COG1252	NADH dehydrogenase
LW858_RS24225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LW858_RS24275	COG0488	(ABC) transporter
LW858_RS24280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS24325	COG0557	exoribonuclease II activity
LW858_RS24330	COG1647	Serine aminopeptidase, S33
LW858_RS24335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LW858_RS24340	COG1346	cytolysis
LW858_RS24380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LW858_RS24395	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LW858_RS24400	COG1668	transmembrane transport
LW858_RS24405	COG4152	abc transporter atp-binding protein
LW858_RS24410	COG4585	Histidine kinase
LW858_RS24440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LW858_RS24455	COG2323	membrane
LW858_RS24465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LW858_RS24475	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LW858_RS24485	COG1051	belongs to the nudix hydrolase family
LW858_RS24505	COG0492	ferredoxin-NADP+ reductase activity
LW858_RS24510	COG0457	Tetratricopeptide repeat
LW858_RS24515	COG0110	maltose O-acetyltransferase activity
LW858_RS24535	COG1950	PFAM Membrane protein of
LW858_RS24540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LW858_RS24545	COG0556	nucleotide-excision repair
LW858_RS24560	COG0789	Transcriptional regulator
LW858_RS24580	COG0583	DNA-binding transcription factor activity
LW858_RS24590	COG0655	NAD(P)H dehydrogenase (quinone) activity
LW858_RS24595	COG0488	(ABC) transporter
LW858_RS24605	COG1132	(ABC) transporter
LW858_RS24610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LW858_RS24615	COG0793	Belongs to the peptidase S41A family
LW858_RS24615	COG3409	Peptidoglycan-binding domain 1 protein
LW858_RS24620	COG2177	Part of the ABC transporter FtsEX involved in
LW858_RS24625	COG2884	Cell division ATP-binding protein ftsE
LW858_RS24655	COG1131	(ABC) transporter
LW858_RS24685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LW858_RS24690	COG1278	Cold shock
LW858_RS24695	COG1040	competence protein
LW858_RS24700	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LW858_RS24705	COG0791	NLP P60 protein
LW858_RS24710	COG1733	regulation of RNA biosynthetic process
LW858_RS24715	COG1307	EDD domain protein, DegV family
LW858_RS24720	COG1739	Uncharacterized protein family UPF0029
LW858_RS24725	COG1316	TRANSCRIPTIONal
LW858_RS24730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LW858_RS24735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LW858_RS24740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LW858_RS24770	COG1486	melibiose metabolic process
LW858_RS24775	COG1447	Phosphotransferase system cellobiose-specific component IIA
LW858_RS24780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LW858_RS24805	COG1447	Phosphotransferase system cellobiose-specific component IIA
LW858_RS24815	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LW858_RS24860	COG0583	DNA-binding transcription factor activity
LW858_RS24875	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LW858_RS24885	COG1271	oxidase subunit
LW858_RS24890	COG1294	oxidase, subunit
LW858_RS24910	COG1620	l-lactate permease
LW858_RS24920	COG2389	metal-binding protein
LW858_RS24930	COG1368	sulfuric ester hydrolase activity
LW858_RS24940	COG0791	NLP P60 protein
LW858_RS24940	COG1388	LysM domain
LW858_RS24945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LW858_RS24955	COG1215	transferase activity, transferring glycosyl groups
LW858_RS24960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LW858_RS24965	COG3584	3D domain protein
LW858_RS24965	COG1388	LysM domain
LW858_RS24995	COG4715	Zinc finger, swim domain protein
LW858_RS25000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LW858_RS25040	COG0577	efflux transmembrane transporter activity
LW858_RS25045	COG1136	(ABC) transporter
LW858_RS25220	COG0582	viral genome integration into host DNA
LW858_RS25240	COG1266	CAAX protease self-immunity
LW858_RS25255	COG0488	(ABC) transporter
LW858_RS25265	COG0456	acetyltransferase
LW858_RS25270	COG1214	PFAM Peptidase M22, glycoprotease
LW858_RS25275	COG0802	atpase or kinase
LW858_RS25375	COG2183	response to ionizing radiation
LW858_RS25380	COG3547	Transposase (IS116 IS110 IS902 family)
LW858_RS25385	COG2337	Toxic component of a toxin-antitoxin (TA) module
LW858_RS25390	COG0864	Transcriptional regulator
LW858_RS25395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LW858_RS25405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LW858_RS25415	COG0705	Rhomboid family
LW858_RS25440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LW858_RS25450	COG2814	Major facilitator Superfamily
LW858_RS25455	COG0531	amino acid
LW858_RS25465	COG0179	Fumarylacetoacetate (FAA) hydrolase
LW858_RS25470	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LW858_RS25500	COG0561	phosphatase activity
LW858_RS25510	COG4608	Belongs to the ABC transporter superfamily
LW858_RS25515	COG0444	Belongs to the ABC transporter superfamily
LW858_RS25520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LW858_RS25525	COG0601	transmembrane transport
LW858_RS25530	COG0747	negative chemotaxis
LW858_RS25540	COG0488	(ABC) transporter
LW858_RS25565	COG5298	Protein conserved in bacteria
LW858_RS25585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LW858_RS25595	COG1609	Transcriptional regulator
LW858_RS25605	COG0204	Acyl-transferase
LW858_RS25620	COG0697	spore germination
LW858_RS25635	COG1910	domain protein
LW858_RS25640	COG0725	ABC transporter, periplasmic molybdate-binding protein
LW858_RS25645	COG4149	molybdate abc transporter
LW858_RS25660	COG0656	L-ascorbic acid biosynthetic process
LW858_RS25665	COG4166	transmembrane transport
LW858_RS25670	COG4166	transmembrane transport
LW858_RS25685	COG2207	Transcriptional regulator
LW858_RS25695	COG4166	transmembrane transport
LW858_RS25700	COG4608	Belongs to the ABC transporter superfamily
LW858_RS25710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LW858_RS25715	COG0601	transmembrane transport
LW858_RS25740	COG2814	Major facilitator Superfamily
LW858_RS25750	COG2271	Major facilitator Superfamily
LW858_RS25765	COG0604	alcohol dehydrogenase
LW858_RS25770	COG1464	Belongs to the NlpA lipoprotein family
LW858_RS25775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LW858_RS25780	COG2011	ABC-type metal ion transport system permease component
LW858_RS25790	COG1028	Short-chain dehydrogenase reductase Sdr
LW858_RS25850	COG4856	YbbR-like protein
LW858_RS25855	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LW858_RS25935	COG0726	polysaccharide deacetylase
LW858_RS25940	COG2194	sulfuric ester hydrolase activity
LW858_RS25950	COG0489	protein tyrosine kinase activity
LW858_RS25955	COG0860	N-Acetylmuramoyl-L-alanine amidase
LW858_RS25980	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LW858_RS26015	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LW858_RS26025	COG0024	Methionine aminopeptidase
LW858_RS26035	COG0201	protein transport
LW858_RS26095	COG0255	Belongs to the universal ribosomal protein uL29 family
LW858_RS26160	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LW858_RS26165	COG1358	cellular component organization or biogenesis
LW858_RS26180	COG2813	Specifically methylates the guanine in position
LW858_RS26200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LW858_RS26205	COG0250	Participates in transcription elongation, termination and antitermination
LW858_RS26210	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LW858_RS26225	COG3688	RNA-binding protein containing a PIN domain
LW858_RS26230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LW858_RS26245	COG1045	serine acetyltransferase
LW858_RS26265	COG4956	integral membrane protein (PIN domain superfamily)
LW858_RS26275	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LW858_RS26280	COG0542	response to heat
LW858_RS26290	COG3880	PFAM UvrB UvrC protein
LW858_RS26380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LW858_RS26385	COG1396	sequence-specific DNA binding
LW858_RS26390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LW858_RS26395	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LW858_RS26400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LW858_RS26405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LW858_RS26410	COG0512	Glutamine amidotransferase of anthranilate synthase
LW858_RS26415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LW858_RS26420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LW858_RS26440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LW858_RS26445	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LW858_RS26460	COG2208	phosphoserine phosphatase activity
LW858_RS26475	COG1098	S1 RNA binding domain
LW858_RS26495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LW858_RS26500	COG3956	TIGRFAM MazG family protein
LW858_RS26505	COG2244	polysaccharide biosynthetic process
LW858_RS26510	COG2002	toxin-antitoxin pair type II binding
LW858_RS26515	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LW858_RS26545	COG0251	oxidation-reduction process
LW858_RS26550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LW858_RS26565	COG4466	Protein conserved in bacteria
LW858_RS26585	COG0084	hydrolase, TatD family'
LW858_RS26595	COG2002	toxin-antitoxin pair type II binding
LW858_RS26600	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LW858_RS26610	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LW858_RS26620	COG1774	PSP1 C-terminal conserved region
LW858_RS26625	COG0470	DNA polymerase III
LW858_RS26635	COG1982	Orn Lys Arg decarboxylase major
LW858_RS26690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LW858_RS26700	COG0590	tRNA wobble adenosine to inosine editing
LW858_RS26705	COG1335	isochorismatase
LW858_RS26710	COG1428	Deoxynucleoside kinase
LW858_RS26715	COG1428	Deoxynucleoside kinase
LW858_RS26750	COG1686	Belongs to the peptidase S11 family
LW858_RS26755	COG0516	GMP reductase activity
LW858_RS26755	COG0517	IMP dehydrogenase activity
LW858_RS26790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LW858_RS26795	COG0187	DNA topoisomerase II activity
LW858_RS26805	COG2501	S4 domain
LW858_RS26810	COG0592	DNA-directed DNA polymerase activity
LW858_RS26820	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LW858_RS26835	COG1847	R3H domain protein
LW858_RS26860	COG1192	Involved in chromosome partitioning
LW858_RS26865	COG1475	DNA binding
LW858_RS26875	COG0668	transmembrane transport
LW858_RS26880	COG4481	Protein conserved in bacteria
LW858_RS26890	COG0012	GTP binding
LW858_RS26910	COG4241	membrane
LW858_RS26915	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LW858_RS26925	COG0305	Participates in initiation and elongation during chromosome replication
LW858_RS26955	COG0745	RESPONSE REGULATOR receiver
LW858_RS26960	COG5002	protein histidine kinase activity
LW858_RS26970	COG4853	Protein conserved in bacteria
LW858_RS26975	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LW858_RS26980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LW858_RS26995	COG5002	protein histidine kinase activity
LW858_RS27005	COG1164	Oligoendopeptidase f
LW858_RS27025	COG1272	protein, Hemolysin III
LW858_RS27030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LW858_RS27060	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
LW858_RS27065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LW858_RS27070	COG2814	Major facilitator Superfamily
LW858_RS27095	COG0628	permease
LW858_RS27100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LW858_RS27100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LW858_RS27110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LW858_RS27115	COG1309	transcriptional regulator
LW858_RS27125	COG0488	(ABC) transporter
LW858_RS27130	COG0463	Glycosyl transferase, family 2
LW858_RS27145	COG1216	Glycosyl transferase, family 2
LW858_RS27160	COG1216	Glycosyl transferase, family 2
LW858_RS27165	COG1607	acyl-coa hydrolase
LW858_RS27190	COG0438	transferase activity, transferring glycosyl groups
LW858_RS27200	COG0477	Major facilitator Superfamily
LW858_RS27205	COG3279	Response regulator of the LytR AlgR family
LW858_RS27210	COG1966	Carbon starvation protein
LW858_RS27215	COG2879	small protein
LW858_RS27220	COG3706	GGDEF domain
LW858_RS27225	COG0351	phosphomethylpyrimidine kinase
LW858_RS27235	COG2197	response regulator
LW858_RS27245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LW858_RS27250	COG1011	Hydrolase
LW858_RS27260	COG2873	o-acetylhomoserine
LW858_RS27270	COG0460	homoserine dehydrogenase
LW858_RS27280	COG1609	Transcriptional regulator
LW858_RS27285	COG2755	lipolytic protein G-D-S-L family
LW858_RS27290	COG1131	(ABC) transporter
LW858_RS27295	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LW858_RS27310	COG2814	Major facilitator Superfamily
LW858_RS27315	COG0561	phosphatase activity
LW858_RS27320	COG2233	PERMEase
LW858_RS27325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LW858_RS27335	COG2363	Small membrane protein
LW858_RS27345	COG3773	Cell wall hydrolase
LW858_RS27360	COG0280	phosphate acetyltransferase
LW858_RS27380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LW858_RS27385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LW858_RS27390	COG1120	ATPase activity
LW858_RS27395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LW858_RS27400	COG1078	dGTPase activity
LW858_RS27410	COG1994	Peptidase M50
LW858_RS27420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LW858_RS27425	COG0584	glycerophosphoryl diester phosphodiesterase
LW858_RS27430	COG0789	Transcriptional regulator
LW858_RS27435	COG2814	Major facilitator Superfamily
LW858_RS27470	COG4506	Protein conserved in bacteria
LW858_RS27480	COG1595	DNA-templated transcription, initiation
LW858_RS27500	COG2234	aminopeptidase activity
LW858_RS27510	COG0024	Methionine aminopeptidase
LW858_RS27520	COG0842	Transport permease protein
LW858_RS27525	COG4585	Histidine kinase
LW858_RS27530	COG2197	response regulator
LW858_RS27535	COG3227	Zinc metalloprotease (Elastase)
LW858_RS27560	COG5001	Diguanylate cyclase
LW858_RS27560	COG3300	MHYT domain
LW858_RS27570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LW858_RS27575	COG2181	nitrate reductase activity
LW858_RS27575	COG0247	lactate metabolic process
LW858_RS27580	COG0183	Belongs to the thiolase family
LW858_RS27585	COG1250	3-hydroxyacyl-CoA dehydrogenase
LW858_RS27590	COG1960	acyl-CoA dehydrogenase activity
LW858_RS27595	COG1960	acyl-CoA dehydrogenase activity
LW858_RS27615	COG4821	SIS domain
LW858_RS27635	COG1494	fructose-1,6-bisphosphatase
LW858_RS27640	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LW858_RS27675	COG0009	L-threonylcarbamoyladenylate synthase
LW858_RS27690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LW858_RS27695	COG2259	Doxx family
LW858_RS27710	COG0698	ribose 5-phosphate isomerase
LW858_RS27745	COG0356	it plays a direct role in the translocation of protons across the membrane
LW858_RS27795	COG5001	Diguanylate cyclase
LW858_RS27795	COG3300	MHYT domain
LW858_RS27810	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LW858_RS27830	COG0839	Belongs to the complex I subunit 6 family
LW858_RS27840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LW858_RS27845	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LW858_RS27850	COG1007	ATP synthesis coupled electron transport
LW858_RS27855	COG4836	Membrane
LW858_RS27870	COG2385	sporulation resulting in formation of a cellular spore
LW858_RS27875	COG3279	Response regulator of the LytR AlgR family
LW858_RS27890	COG0739	heme binding
LW858_RS27900	COG1609	Transcriptional regulator
LW858_RS27915	COG0489	protein tyrosine kinase activity
LW858_RS27920	COG3944	biosynthesis protein
LW858_RS27925	COG0489	protein tyrosine kinase activity
LW858_RS27930	COG4464	protein tyrosine phosphatase activity
LW858_RS27935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LW858_RS27940	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LW858_RS27945	COG1216	Glycosyl transferase, family 2
LW858_RS27950	COG1216	Glycosyl transferase, family 2
LW858_RS27950	COG1442	glycosyl transferase family 8
LW858_RS27980	COG0662	Cupin 2, conserved barrel domain protein
LW858_RS27980	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LW858_RS27985	COG1482	cell wall glycoprotein biosynthetic process
LW858_RS27990	COG1316	TRANSCRIPTIONal
LW858_RS27995	COG5039	Polysaccharide pyruvyl transferase
LW858_RS28010	COG3475	LICD family
LW858_RS28035	COG0697	spore germination
LW858_RS28040	COG4750	Nucleotidyl transferase
LW858_RS28045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LW858_RS28050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LW858_RS28055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LW858_RS28060	COG3711	transcriptional antiterminator
LW858_RS28060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LW858_RS28065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LW858_RS28065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LW858_RS28065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LW858_RS28070	COG1482	cell wall glycoprotein biosynthetic process
LW858_RS28075	COG0745	RESPONSE REGULATOR receiver
LW858_RS28080	COG5002	protein histidine kinase activity
LW858_RS28105	COG1136	(ABC) transporter
LW858_RS28110	COG0577	efflux transmembrane transporter activity
LW858_RS28125	COG2252	PERMEase
LW858_RS28135	COG5002	protein histidine kinase activity
LW858_RS28155	COG0697	spore germination
LW858_RS28185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LW858_RS28190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LW858_RS28195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LW858_RS28205	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LW858_RS28220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LW858_RS28230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LW858_RS28240	COG0151	Belongs to the GarS family
LW858_RS28265	COG0210	DNA helicase
LW858_RS28275	COG4851	CamS sex pheromone cAM373 precursor
LW858_RS28290	COG1335	isochorismatase
LW858_RS28300	COG2011	ABC-type metal ion transport system permease component
LW858_RS28305	COG1464	Belongs to the NlpA lipoprotein family
LW858_RS28310	COG4682	membrane
LW858_RS28330	COG1597	lipid kinase activity
LW858_RS28340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LW858_RS28350	COG1012	belongs to the aldehyde dehydrogenase family
LW858_RS28355	COG2076	Multidrug Resistance protein
LW858_RS28365	COG2309	aminopeptidase activity
LW858_RS28375	COG0582	viral genome integration into host DNA
LW858_RS28385	COG1396	sequence-specific DNA binding
LW858_RS28435	COG3617	BRO family, N-terminal domain
LW858_RS28460	COG0582	viral genome integration into host DNA
LW858_RS28600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LW858_RS28660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LW858_RS28670	COG4807	Protein conserved in bacteria
LW858_RS28710	COG1757	Na H antiporter
LW858_RS28715	COG1473	amidohydrolase
LW858_RS28735	COG0450	alkyl hydroperoxide reductase
LW858_RS28755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LW858_RS28760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LW858_RS28765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LW858_RS28770	COG0492	ferredoxin-NADP+ reductase activity
LW858_RS28780	COG0166	Belongs to the GPI family
LW858_RS28815	COG5002	protein histidine kinase activity
LW858_RS28835	COG3541	Predicted nucleotidyltransferase
LW858_RS28840	COG2814	Major facilitator Superfamily
LW858_RS28845	COG0723	plastoquinol--plastocyanin reductase activity
LW858_RS28845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LW858_RS28855	COG0765	amino acid transport
LW858_RS28860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LW858_RS28865	COG1126	abc transporter atp-binding protein
LW858_RS28870	COG0840	transmembrane signaling receptor activity
LW858_RS28895	COG0549	Belongs to the carbamate kinase family
LW858_RS28900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LW858_RS28910	COG0277	FAD linked oxidase domain protein
LW858_RS28915	COG0366	Alpha amylase catalytic
LW858_RS28960	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LW858_RS28985	COG1396	sequence-specific DNA binding
LW858_RS29000	COG3646	Phage regulatory protein
LW858_RS29070	COG0582	viral genome integration into host DNA
LW858_RS29200	COG0531	amino acid
LW858_RS29205	COG0697	spore germination
LW858_RS29225	COG0456	acetyltransferase
LW858_RS29230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LW858_RS29285	COG0681	Belongs to the peptidase S26 family
LW858_RS29300	COG1136	(ABC) transporter
LW858_RS29360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LW858_RS29405	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LW858_RS29430	COG3547	Transposase (IS116 IS110 IS902 family)
LW858_RS29460	COG0681	Belongs to the peptidase S26 family
LW858_RS29500	COG1216	Glycosyl transferase, family 2
LW858_RS29505	COG1216	Glycosyl transferase, family 2
LW858_RS29535	COG1216	Glycosyl transferase, family 2
LW858_RS29550	COG1216	Glycosyl transferase, family 2
LW858_RS29565	COG1215	transferase activity, transferring glycosyl groups
LW858_RS29590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LW858_RS29685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LW858_RS29685	COG1263	PTS System
LW858_RS29760	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
LW858_RS29905	COG0463	Glycosyl transferase, family 2
LW858_RS29980	COG0697	spore germination
LW858_RS30080	COG2002	toxin-antitoxin pair type II binding
LW858_RS30085	COG1923	regulation of RNA biosynthetic process
LW858_RS30180	COG1404	Belongs to the peptidase S8 family
LW858_RS30235	COG1136	(ABC) transporter
LW858_RS30290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LW858_RS30325	COG3654	unkown
LW858_RS30380	COG0681	Belongs to the peptidase S26 family
LW858_RS30415	COG0745	RESPONSE REGULATOR receiver
LW858_RS30495	COG2801	Transposase and inactivated derivatives
LW858_RS30535	COG2801	Transposase and inactivated derivatives
LW858_RS30725	COG0586	Pfam SNARE associated Golgi protein
LW858_RS30750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LW858_RS30780	COG2002	toxin-antitoxin pair type II binding
LW858_RS30800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LW858_RS30875	COG0861	Integral membrane protein TerC family
LW858_RS30970	COG2368	4-hydroxyphenylacetate
LW858_RS31035	COG2801	Transposase and inactivated derivatives
LW858_RS31065	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LW858_RS31075	COG4413	Urea transporter
LW858_RS31080	COG0831	urea catabolic process
LW858_RS31085	COG0832	Belongs to the urease beta subunit family
LW858_RS31090	COG0804	urea catabolic process
LW858_RS31095	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LW858_RS31100	COG0830	nickel cation binding
LW858_RS31105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LW858_RS31110	COG0829	nickel cation binding
LW858_RS31140	COG1216	Glycosyl transferase, family 2
LW858_RS31190	COG1136	(ABC) transporter
LW858_RS31205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LW858_RS31205	COG2755	lipolytic protein G-D-S-L family
LW858_RS31220	COG2311	Membrane
LW858_RS31230	COG4851	CamS sex pheromone cAM373 precursor
LW858_RS31285	COG0531	amino acid
LW858_RS31305	COG2801	Transposase and inactivated derivatives
LW858_RS31325	COG0823	Involved in the tonB-independent uptake of proteins
LW858_RS31380	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LW858_RS31385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LW858_RS31465	COG1923	regulation of RNA biosynthetic process
LW858_RS31470	COG2002	toxin-antitoxin pair type II binding
LW858_RS31575	COG1396	sequence-specific DNA binding
LW858_RS31745	COG0577	efflux transmembrane transporter activity
LW858_RS31750	COG1136	(ABC) transporter
LW858_RS31800	COG0697	spore germination
LW858_RS31820	COG2755	lipolytic protein G-D-S-L family
LW858_RS31820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LW858_RS31885	COG3335	DDE superfamily endonuclease
LW858_RS31960	COG2133	pyrroloquinoline quinone binding
LW858_RS31960	COG5183	chlorophyll binding
LW858_RS32000	COG1725	Transcriptional regulator
LW858_RS32010	COG0577	efflux transmembrane transporter activity
LW858_RS32015	COG1136	(ABC) transporter
LW858_RS32030	COG3402	PFAM membrane-flanked domain
LW858_RS32105	COG1136	(ABC) transporter
LW858_RS32230	COG4644	lycopene metabolic process
LW858_RS32305	COG1923	regulation of RNA biosynthetic process
LW858_RS32310	COG2002	toxin-antitoxin pair type II binding
LW858_RS32335	COG1309	transcriptional regulator
LW858_RS32355	COG1923	regulation of RNA biosynthetic process
LW858_RS32395	COG1396	sequence-specific DNA binding
LW858_RS32485	COG3505	Type IV secretory pathway VirD4
LW858_RS32520	COG0791	NLP P60 protein
LW858_RS32520	COG3883	PFAM NLP P60 protein
LW858_RS32590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LW858_RS32610	COG2002	toxin-antitoxin pair type II binding
LW858_RS32625	COG0328	RNA-DNA hybrid ribonuclease activity
LW858_RS32625	COG3341	Caulimovirus viroplasmin
LW858_RS32640	COG4644	lycopene metabolic process
LW858_RS32680	COG1131	(ABC) transporter
LW858_RS32700	COG1136	(ABC) transporter
LW858_RS32705	COG0577	efflux transmembrane transporter activity
LW858_RS32720	COG4974	Belongs to the 'phage' integrase family
LW858_RS32830	COG1674	ftsk spoiiie
LW858_RS32845	COG0457	Tetratricopeptide repeat
LW858_RS32895	COG0659	secondary active sulfate transmembrane transporter activity
LW858_RS32900	COG0288	reversible hydration of carbon dioxide
LW858_RS32915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LW858_RS32915	COG2755	lipolytic protein G-D-S-L family
LW858_RS32970	COG1136	(ABC) transporter
LW858_RS33035	COG1923	regulation of RNA biosynthetic process
LW858_RS33255	COG1785	Belongs to the alkaline phosphatase family
LW858_RS33435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LW858_RS33490	COG4644	lycopene metabolic process
LW858_RS33515	COG0534	Mate efflux family protein
LW858_RS33525	COG0534	Mate efflux family protein
LW858_RS33590	COG0659	secondary active sulfate transmembrane transporter activity
LW858_RS33595	COG0288	reversible hydration of carbon dioxide
LW858_RS33605	COG2356	endonuclease I
LW858_RS33610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LW858_RS33615	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LW858_RS33715	COG1404	Belongs to the peptidase S8 family
LW858_RS33740	COG1388	LysM domain
LW858_RS33740	COG3584	3D domain protein