locus-tag class description HPG46_RS00085 ENOG4108Z0C Uvrb UvrC protein HPG46_RS00100 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HPG46_RS00110 ENOG4105CTP PilT protein domain protein HPG46_RS00130 ENOG4105D7W serine acetyltransferase HPG46_RS00145 ENOG4105C2N RNA methyltransferase TrmH family group 3 HPG46_RS00150 ENOG4105M0M Tetracycline resistance protein HPG46_RS00155 ENOG4105QIV RNA polymerase HPG46_RS00170 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HPG46_RS00195 ENOG4107Y49 methyltransferase HPG46_RS00210 ENOG4105XPM ribosomal protein HPG46_RS00340 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPG46_RS00350 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPG46_RS00395 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HPG46_RS00425 ENOG4105D1F ATP-binding protein HPG46_RS00440 ENOG4108NMV polysaccharide deacetylase HPG46_RS00520 ENOG4105C8B TIGR00159 family HPG46_RS00525 ENOG4107U5W ybbr family HPG46_RS00550 ENOG4108VQT Alpha beta hydrolase fold protein HPG46_RS00560 ENOG4105CMG Carbohydrate kinase HPG46_RS00570 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HPG46_RS00575 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HPG46_RS00595 ENOG4108PSK reductase HPG46_RS00600 ENOG4108UMI ABC transporter, permease HPG46_RS00605 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPG46_RS00610 ENOG4105D01 (LipO)protein HPG46_RS00625 ENOG4105IQ5 FAD linked oxidase domain protein HPG46_RS00640 ENOG4105C2C drug resistance transporter, Bcr CflA HPG46_RS00655 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPG46_RS00660 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG46_RS00665 ENOG4105C3U ABC transporter HPG46_RS00670 ENOG4108JQ7 (ABC) transporter HPG46_RS00700 ENOG4108J59 Extracellular solute-binding protein, family 5 HPG46_RS00705 ENOG4108J59 Extracellular solute-binding protein, family 5 HPG46_RS00715 ENOG4105II7 pyrroline-5-carboxylate reductase HPG46_RS00720 ENOG4107XDY Nicotinamide Mononucleotide Transporter HPG46_RS00730 ENOG4105E0C molybdate abc transporter HPG46_RS00735 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPG46_RS00740 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HPG46_RS00770 ENOG4105F6E Acyl-transferase HPG46_RS00790 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HPG46_RS00810 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HPG46_RS00835 ENOG4105C5H ABC transporter HPG46_RS00850 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HPG46_RS00860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG46_RS00865 ENOG4105C3U ABC transporter HPG46_RS00870 ENOG4108JQ7 (ABC) transporter HPG46_RS00875 ENOG410667J hydrolase HPG46_RS00905 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HPG46_RS00910 ENOG4105ERH Fumarylacetoacetate hydrolase HPG46_RS00920 ENOG4105CUB amino acid HPG46_RS00925 ENOG4108SC4 )-transporter HPG46_RS00930 ENOG4105CPF Cell wall formation (By similarity) HPG46_RS00935 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HPG46_RS00950 ENOG4107ZXI Rhomboid family HPG46_RS00960 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HPG46_RS00965 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPG46_RS00975 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HPG46_RS01075 ENOG4105K8N protein family UPF0079, ATPase HPG46_RS01080 ENOG41072GX Peptidase M22 Glycoprotease HPG46_RS01085 ENOG410801F ribosomal-protein-alanine acetyltransferase HPG46_RS01095 ENOG4105C5H ABC transporter HPG46_RS01110 ENOG4108TYN CAAX amino terminal protease family protein HPG46_RS01130 ENOG4105C7N Xanthine uracil vitamin C permease HPG46_RS01140 ENOG4105BZU Histidine kinase HPG46_RS01165 ENOG4107ZXU DSBA oxidoreductase HPG46_RS01195 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPG46_RS01215 ENOG4108SHN Glycosyl transferase, family 2 HPG46_RS01260 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_RS01280 ENOG4105SX7 Transporter HPG46_RS01305 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HPG46_RS01310 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HPG46_RS01315 ENOG4105C83 adenylosuccinate lyase HPG46_RS01325 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HPG46_RS01350 ENOG4108V3E phosphoribosylglycinamide formyltransferase HPG46_RS01360 ENOG4105C12 Phosphoribosylglycinamide synthetase HPG46_RS01385 ENOG4105C4R Atp-dependent dna helicase HPG46_RS01415 ENOG4108W2Y isochorismatase HPG46_RS01420 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPG46_RS01425 ENOG4108UMI ABC transporter, permease HPG46_RS01430 ENOG4105D01 (LipO)protein HPG46_RS01450 ENOG410834F Transcriptional regulator HPG46_RS01455 ENOG4107I77 yiaA/B two helix domain HPG46_RS01475 ENOG4105CBD Diacylglycerol kinase HPG46_RS01480 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPG46_RS01485 ENOG4108JPW Aminotransferase HPG46_RS01495 ENOG4105C26 Dehydrogenase HPG46_RS01500 ENOG4105KPY Small multidrug resistance protein HPG46_RS01520 ENOG4105D9N nucleoside HPG46_RS01525 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPG46_RS01535 ENOG4105BZU Histidine kinase HPG46_RS01540 ENOG4108W15 Protein of unknown function (DUF1456) HPG46_RS01555 ENOG4105DTQ mandelate racemase muconate lactonizing HPG46_RS01565 ENOG4105DFD Na H antiporter HPG46_RS01585 ENOG4105D3R alkyl hydroperoxide reductase HPG46_RS01605 ENOG4105EHG Permease protein HPG46_RS01610 ENOG4105DQ5 transport system permease protein HPG46_RS01615 ENOG4108V5C ABC transporter HPG46_RS01635 ENOG4106UIA HPG46_RS01640 ENOG4106UIA HPG46_RS01685 ENOG410756H nucleotidyltransferase HPG46_RS01690 ENOG4105D2S major facilitator superfamily HPG46_RS01705 ENOG4105E5Q amino acid AbC transporter HPG46_RS01710 ENOG4105EAB amino acid AbC transporter HPG46_RS01720 ENOG4105C8Q Methyl-accepting chemotaxis HPG46_RS01725 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPG46_RS01735 ENOG4105CI1 PTS System HPG46_RS01765 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPG46_RS01780 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPG46_RS01800 ENOG4105C5H ABC transporter HPG46_RS01830 ENOG41062JF Transcriptional regulator HPG46_RS01850 ENOG4105DEU major facilitator superfamily HPG46_RS01880 ENOG4108N0M stress protein HPG46_RS01885 ENOG4106FN3 tellurium resistance protein HPG46_RS01890 ENOG4106FN3 tellurium resistance protein HPG46_RS01895 ENOG4107TS3 membrane protein, TerC HPG46_RS01900 ENOG4108TTB tellurium resistance protein HPG46_RS01920 ENOG4105KJF protein tyrosine phosphatase HPG46_RS01930 ENOG4107U9T Pfam:Ribonuclease_BN HPG46_RS01935 ENOG4105C59 p-type ATPase HPG46_RS01940 ENOG4108IPJ Membrane HPG46_RS01950 ENOG4105C3F Signal peptidase i HPG46_RS01960 ENOG4107ZTW SNARE associated Golgi HPG46_RS01975 ENOG410606W general stress protein HPG46_RS01980 ENOG4105UPD Calcium Proton HPG46_RS02015 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPG46_RS02030 ENOG4108JUB Transcriptional regulator HPG46_RS02040 ENOG4108IQI permease HPG46_RS02080 ENOG4108A04 Beta-lactamase HPG46_RS02100 ENOG4105CKK Glycosyl transferase, family 2 HPG46_RS02105 ENOG4107QQG Dehydrogenase HPG46_RS02110 ENOG4105C3I Nad-dependent epimerase dehydratase HPG46_RS02130 ENOG4105F1A Pyruvate formate-lyase HPG46_RS02150 ENOG4105CI2 imidazolone-5-propionate hydrolase HPG46_RS02155 ENOG4105ECP epimerase HPG46_RS02185 ENOG41067AE Membrane-bound metal-dependent hydrolase HPG46_RS02190 ENOG4105CEN a g-specific adenine glycosylase HPG46_RS02195 ENOG4106BXE HPG46_RS02215 ENOG4105BZ1 (ABC) transporter HPG46_RS02220 ENOG4107NBY Membrane HPG46_RS02225 ENOG4105CBC glutamate synthase HPG46_RS02235 ENOG4108IUW ABC transporter HPG46_RS02255 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPG46_RS02260 ENOG4105G5W regulator Fur family HPG46_RS02375 ENOG4108JQC penicillin-binding protein 1A HPG46_RS02380 ENOG4107ZQN disulfide bond HPG46_RS02390 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HPG46_RS02400 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HPG46_RS02405 ENOG4105BZU Histidine kinase HPG46_RS02410 ENOG4105CYN Serine protein kinase HPG46_RS02430 ENOG4105C94 Transporter HPG46_RS02445 ENOG4105DZ6 Band 7 protein HPG46_RS02455 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HPG46_RS02460 ENOG4108V9W transcriptional regulatory protein HPG46_RS02465 ENOG4105D4T Citrate transporter HPG46_RS02485 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HPG46_RS02490 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPG46_RS02495 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HPG46_RS02500 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HPG46_RS02505 ENOG4105BZ7 extracellular solute-binding protein family 1 HPG46_RS02510 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HPG46_RS02515 ENOG4108STX response regulator HPG46_RS02520 ENOG4105US7 Histidine kinase HPG46_RS02545 ENOG4108MRH transcriptional regulatory protein HPG46_RS02555 ENOG4105C6K Malic enzyme HPG46_RS02565 ENOG4108UZ3 Transporter HPG46_RS02570 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPG46_RS02580 ENOG4105BZU Histidine kinase HPG46_RS02585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS02590 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HPG46_RS02595 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HPG46_RS02600 ENOG4108JB9 formate dehydrogenase HPG46_RS02620 ENOG4105CUB amino acid HPG46_RS02630 ENOG4105C59 p-type ATPase HPG46_RS02635 ENOG4105DAP Nicotinate phosphoribosyltransferase HPG46_RS02670 ENOG41073R8 VanW family HPG46_RS02675 ENOG4108KGH TRANSCRIPTIONal HPG46_RS02680 ENOG4105D9N nucleoside HPG46_RS02685 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HPG46_RS02690 ENOG4105C37 (CBS) domain HPG46_RS02695 ENOG4108IJ0 Aspartate ammonia-lyase HPG46_RS02700 ENOG4105DAA L-lactate HPG46_RS02715 ENOG4105DUX Transporter HPG46_RS02720 ENOG4108MES Periplasmic binding protein HPG46_RS02725 ENOG4105DQ5 transport system permease protein HPG46_RS02730 ENOG4108IHU transport system permease protein HPG46_RS02735 ENOG4105E0A ABC, transporter HPG46_RS02740 ENOG4105DMQ Methyltransferase HPG46_RS02750 ENOG4105EXW epimerase dehydratase HPG46_RS02755 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HPG46_RS02765 ENOG4107T89 von Willebrand factor, type A HPG46_RS02770 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HPG46_RS02775 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HPG46_RS02790 ENOG4105BZU Histidine kinase HPG46_RS02795 ENOG4105D5Q Arginine ornithine antiporter HPG46_RS02800 ENOG4107414 GntR family transcriptional regulator HPG46_RS02805 ENOG4105C5Y PTS System HPG46_RS02810 ENOG4105CG3 alpha amylase, catalytic region HPG46_RS02825 ENOG4105E1K spore germination protein HPG46_RS02835 ENOG4105CRN Aminoglycoside phosphotransferase HPG46_RS02840 ENOG4105BZG amino acid carrier protein HPG46_RS02845 ENOG4105CDA abc transporter atp-binding protein HPG46_RS02850 ENOG4105CT1 (ABC) transporter HPG46_RS02855 ENOG4105EAD ABC transporter HPG46_RS02860 ENOG4105DRP amino acid AbC transporter HPG46_RS02865 ENOG4108IQI permease HPG46_RS02890 ENOG4105D29 Helix-turn-helix type 11 domain protein HPG46_RS02895 ENOG4105NAE bifunctional deaminase-reductase domain protein HPG46_RS02900 ENOG4105BZU Histidine kinase HPG46_RS02905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS02915 ENOG4105CHH sulfate transporter HPG46_RS02920 ENOG41068KF Universal stress protein HPG46_RS02930 ENOG4105DEF Extracellular solute-binding protein, family 5 HPG46_RS02940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPG46_RS02945 ENOG4108JQ7 (ABC) transporter HPG46_RS02955 ENOG4105CXY transporter HPG46_RS02960 ENOG41067TZ transcriptional regulator, MarR family HPG46_RS02965 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_RS02970 ENOG4105ETE Transcriptional regulator (LacI family HPG46_RS02975 ENOG4108RVA ribokinase HPG46_RS02990 ENOG4105CNN ABC, transporter HPG46_RS02995 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPG46_RS03055 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HPG46_RS03060 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPG46_RS03065 ENOG41069ER domain protein HPG46_RS03070 ENOG4105VZ8 Transcriptional regulator HPG46_RS03075 ENOG4107D63 HPG46_RS03085 ENOG4105DUX Transporter HPG46_RS03095 ENOG4105D01 (LipO)protein HPG46_RS03100 ENOG4105FDT acyl-CoA dehydrogenase HPG46_RS03105 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPG46_RS03110 ENOG4108UMI ABC transporter, permease HPG46_RS03125 ENOG4105C85 amino acid HPG46_RS03130 ENOG4105C7N Xanthine uracil vitamin C permease HPG46_RS03145 ENOG4105MA6 gCN5-related N-acetyltransferase HPG46_RS03170 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPG46_RS03175 ENOG4105E2S oxidase) subunit II HPG46_RS03180 ENOG4108IQI permease HPG46_RS03195 ENOG4106CAD Protein of unknown function (DUF3311) HPG46_RS03200 ENOG4105E1V na solute symporter HPG46_RS03215 ENOG4108NHD germination protein HPG46_RS03220 ENOG4105CE1 Ferrous iron transport protein b HPG46_RS03225 ENOG4105CE1 Ferrous iron transport protein b HPG46_RS03230 ENOG4105CE1 Ferrous iron transport protein b HPG46_RS03235 ENOG4105CVA phosphate HPG46_RS03240 ENOG4105C8U phosphate abc transporter HPG46_RS03245 ENOG4105E2Z phosphate ABC transporter (Permease HPG46_RS03375 ENOG41080XQ Signal transduction protein with cbs domains HPG46_RS03395 ENOG4105ETU transcriptional activator (TenA HPG46_RS03405 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPG46_RS03415 ENOG4108VEU Thiamine monophosphate synthase HPG46_RS03420 ENOG41080HI glycine oxidase HPG46_RS03435 ENOG4105D06 uba thif-type nad fad binding protein HPG46_RS03440 ENOG4105DWF phosphomethylpyrimidine kinase HPG46_RS03490 ENOG4108INS Transcriptional regulator HPG46_RS03515 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPG46_RS03525 ENOG4105CNN ABC, transporter HPG46_RS03530 ENOG4105C2J ABC transporter HPG46_RS03540 ENOG4105C7N Xanthine uracil vitamin C permease HPG46_RS03550 ENOG4108PXI ErfK YbiS YcfS YnhG HPG46_RS03585 ENOG4108B31 Spore germination protein HPG46_RS03605 ENOG4107Y03 Nitroreductase HPG46_RS03610 ENOG4105ED1 spovr family HPG46_RS03615 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HPG46_RS03620 ENOG4105XTG Pfam:DUF156 HPG46_RS03625 ENOG4105VFE sira family HPG46_RS03630 ENOG4107TPS domain protein HPG46_RS03635 ENOG4105VFE sira family HPG46_RS03640 ENOG41085GJ domain protein HPG46_RS03650 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HPG46_RS03655 ENOG41087NI Sulfite exporter TauE/SafE HPG46_RS03665 ENOG4108KGH TRANSCRIPTIONal HPG46_RS03690 ENOG4105EMD TRANSCRIPTIONal HPG46_RS03695 ENOG4105VCP PTS System HPG46_RS03700 ENOG4105VZJ PTS System HPG46_RS03720 ENOG41069ER domain protein HPG46_RS03725 ENOG4107RBB ABC transporter, permease HPG46_RS03730 ENOG4105C19 ABC transporter HPG46_RS03760 ENOG4105WEF catalase HPG46_RS03795 ENOG4107T5V SNARE associated Golgi HPG46_RS03830 ENOG4105CUB amino acid HPG46_RS03835 ENOG4107RWR Sodium hydrogen exchanger HPG46_RS03845 ENOG4106KNT transcriptional regulator HPG46_RS03880 ENOG4108PCN EamA-like transporter family HPG46_RS03885 ENOG4108YXU transcriptional regulator AsnC family HPG46_RS03900 ENOG4105KPY Small multidrug resistance protein HPG46_RS03920 ENOG4105YA8 Transcriptional regulator HPG46_RS03925 ENOG4106A3M Cytochrome p-450 HPG46_RS03940 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HPG46_RS03945 ENOG4105E5W Transporter HPG46_RS03955 ENOG4107RKG DJ-1/PfpI family HPG46_RS03960 ENOG4105CH6 catalase HPG46_RS03970 ENOG4105D5Q Arginine ornithine antiporter HPG46_RS03975 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HPG46_RS03985 ENOG4105C26 Dehydrogenase HPG46_RS03990 ENOG4105BZ1 (ABC) transporter HPG46_RS03995 ENOG4105BZ1 (ABC) transporter HPG46_RS04005 ENOG4105DRP amino acid AbC transporter HPG46_RS04010 ENOG4105CDA abc transporter atp-binding protein HPG46_RS04025 ENOG410839P HPG46_RS04060 ENOG4107FQX Alpha-acetolactate decarboxylase HPG46_RS04075 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HPG46_RS04080 ENOG4105D4P Coproporphyrinogen iii oxidase HPG46_RS04085 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_RS04095 ENOG4105CHH sulfate transporter HPG46_RS04140 ENOG4106AKK s-layer domain-containing protein HPG46_RS04150 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPG46_RS04155 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPG46_RS04170 ENOG4105CGU Enoyl-CoA hydratase HPG46_RS04195 ENOG4105DER m42 family HPG46_RS04215 ENOG4105CTU Proline racemase HPG46_RS04260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG46_RS04270 ENOG4108JQ7 (ABC) transporter HPG46_RS04285 ENOG4105CSH Transporter HPG46_RS04295 ENOG4108MRH transcriptional regulatory protein HPG46_RS04360 ENOG4105CDU Replicative dna helicase HPG46_RS04400 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_RS04445 ENOG4107P5I polyketide synthase HPG46_RS04450 ENOG4108IG5 Transcriptional regulator HPG46_RS04465 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HPG46_RS04485 ENOG4105CMT Dihydroxyacetone kinase HPG46_RS04495 ENOG4105CMT Dihydroxyacetone kinase HPG46_RS04505 ENOG410847I Transcriptional regulator, BadM Rrf2 family HPG46_RS04550 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HPG46_RS04645 ENOG4105WN5 stage II sporulation protein HPG46_RS04655 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_RS04665 ENOG4108MJI response regulator HPG46_RS04670 ENOG4105BZU Histidine kinase HPG46_RS04675 ENOG4105BZU Histidine kinase HPG46_RS04730 ENOG4107VRP DNA repair exonuclease HPG46_RS04735 ENOG4106D4I domain protein HPG46_RS04790 ENOG4108MUZ hydrolase HPG46_RS04810 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HPG46_RS04825 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HPG46_RS04845 ENOG4105EMN RNA polymerase sigma factor HPG46_RS04870 ENOG4105C57 major facilitator superfamily HPG46_RS04875 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_RS04885 ENOG4105EEM helicase HPG46_RS04890 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HPG46_RS04915 ENOG4105K59 histidine triad (HIT) protein HPG46_RS04990 ENOG410905X membrane-flanked domain protein HPG46_RS04995 ENOG4105CKV Membrane HPG46_RS05035 ENOG410905X membrane-flanked domain protein HPG46_RS05040 ENOG4105CKV Membrane HPG46_RS05045 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HPG46_RS05050 ENOG4105BZ4 penicillin-binding protein HPG46_RS05065 ENOG4105C1Q protoporphyrinogen oxidase HPG46_RS05090 ENOG4105NA0 Transcriptional regulator HPG46_RS05105 ENOG4105ECB domain protein HPG46_RS05130 ENOG4105D29 Helix-turn-helix type 11 domain protein HPG46_RS05140 ENOG4106AXD HPG46_RS05145 ENOG4108RQ5 Beta-lactamase domain-containing protein HPG46_RS05150 ENOG4105DF9 Lipoate-protein, ligase HPG46_RS05160 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_RS05180 ENOG4107RN3 metallophosphoesterase HPG46_RS05190 ENOG4107TVP HD domain protein HPG46_RS05200 ENOG4108AEY RNA polymerase sigma factor HPG46_RS05205 ENOG41086D8 Transcriptional regulator HPG46_RS05225 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_RS05250 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HPG46_RS05255 ENOG4105C8Q Methyl-accepting chemotaxis HPG46_RS05280 ENOG4107QP3 malate synthase g HPG46_RS05310 ENOG4105XVF Competence transcription factor HPG46_RS05375 ENOG4105ERH Fumarylacetoacetate hydrolase HPG46_RS05400 ENOG4105CAQ asparagine synthetase HPG46_RS05405 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HPG46_RS05410 ENOG4105CH6 catalase HPG46_RS05415 ENOG4105BZU Histidine kinase HPG46_RS05435 ENOG4105QNR S1 RNA binding domain protein HPG46_RS05445 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HPG46_RS05455 ENOG4107AYK membrAne HPG46_RS05460 ENOG41073B9 HPG46_RS05470 ENOG4108KP7 hydrolase HPG46_RS05480 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPG46_RS05505 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPG46_RS05510 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPG46_RS05525 ENOG4105C31 Tryptophanyl-tRNA synthetase HPG46_RS05540 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPG46_RS05545 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG46_RS05555 ENOG4108JQ7 (ABC) transporter HPG46_RS05560 ENOG4105UQX Mate efflux family protein HPG46_RS05580 ENOG4108ZCF integral membrane protein HPG46_RS05590 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HPG46_RS05600 ENOG4105DPN Oligoendopeptidase f HPG46_RS05615 ENOG4108Z18 K06886 hemoglobin HPG46_RS05620 ENOG4105MIX Adenylate cyclase HPG46_RS05640 ENOG4105EMS pseudouridine synthase HPG46_RS05660 ENOG4105K64 Glycosyl transferase, family 2 HPG46_RS05680 ENOG4107TVC Glycosyl transferase, family 2 HPG46_RS05700 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HPG46_RS05705 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HPG46_RS05715 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HPG46_RS05790 ENOG4105CK7 Sodium proline symporter HPG46_RS05800 ENOG4105DDQ anthranilate synthase HPG46_RS05895 ENOG4105C7S Dehydrogenase HPG46_RS05905 ENOG4105VZ8 Transcriptional regulator HPG46_RS05960 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HPG46_RS05970 ENOG4105DZ1 carboxypeptidase HPG46_RS05975 ENOG4105VFR signal peptidase HPG46_RS06010 ENOG4105C26 Dehydrogenase HPG46_RS06020 ENOG4105F38 ABC transporter, permease HPG46_RS06025 ENOG4105D38 putrescine abc transporter HPG46_RS06030 ENOG4107RUE extracellular solute-binding protein family 1 HPG46_RS06040 ENOG4105EYF MMPL domain protein HPG46_RS06050 ENOG4108YBP pseudouridine synthase HPG46_RS06060 ENOG4105K4I Scp-like extracellular HPG46_RS06065 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPG46_RS06070 ENOG4105CQB FAD linked oxidase domain protein HPG46_RS06085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS06090 ENOG4105BZU Histidine kinase HPG46_RS06095 ENOG4105JXH GntR family transcriptional regulator HPG46_RS06115 ENOG4106A3R peptidase HPG46_RS06125 ENOG4108QTI )-transporter HPG46_RS06130 ENOG4107TS3 membrane protein, TerC HPG46_RS06135 ENOG4105CZN Potassium uptake protein HPG46_RS06140 ENOG410681C small acid-soluble spore protein HPG46_RS06145 ENOG4108Z7G MaoC domain protein dehydratase HPG46_RS06165 ENOG4105CHR reductase HPG46_RS06175 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPG46_RS06195 ENOG4105C4Y ABC transporter HPG46_RS06200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPG46_RS06205 ENOG4107RCV ABC transporter, permease HPG46_RS06225 ENOG4105E98 transcriptional regulator DeoR family HPG46_RS06235 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HPG46_RS06245 ENOG4105PXI polysaccharide deacetylase HPG46_RS06255 ENOG4105BZU Histidine kinase HPG46_RS06260 ENOG41090MY MarR family Transcriptional regulator HPG46_RS06270 ENOG4106DF1 HPG46_RS06275 ENOG4105BZU Histidine kinase HPG46_RS06285 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HPG46_RS06290 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HPG46_RS06330 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HPG46_RS06350 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPG46_RS06355 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HPG46_RS06360 ENOG4105CZV ABC transporter HPG46_RS06370 ENOG4105CJ1 ABC, transporter HPG46_RS06410 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPG46_RS06415 ENOG4105EA8 2-Nitropropane dioxygenase HPG46_RS06420 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HPG46_RS06430 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPG46_RS06455 ENOG4105NQC Flavodoxin HPG46_RS06495 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HPG46_RS06525 ENOG4105CZN Potassium uptake protein HPG46_RS06530 ENOG41063Y9 HPG46_RS06535 ENOG4105KBJ sporulation protein ytfj HPG46_RS06555 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPG46_RS06560 ENOG4105C7K acetolactate synthase HPG46_RS06565 ENOG4108ZP8 Acetolactate synthase small subunit HPG46_RS06640 ENOG4107RVV histidinol phosphate phosphatase, hisj family HPG46_RS06655 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HPG46_RS06660 ENOG4105E0M Sulfatase HPG46_RS06670 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HPG46_RS06690 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HPG46_RS06695 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HPG46_RS06705 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HPG46_RS06710 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HPG46_RS06715 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HPG46_RS06720 ENOG4105C8J )-transporter HPG46_RS06740 ENOG4105DFD Na H antiporter HPG46_RS06760 ENOG4105ENE Histidine kinase HPG46_RS06765 ENOG4105WH1 Two component transcriptional regulator luxr family HPG46_RS06785 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HPG46_RS06830 ENOG4105CJ3 phosphate transporter HPG46_RS06835 ENOG4107GRR phosphate transport regulator HPG46_RS06840 ENOG4105BZ4 penicillin-binding protein HPG46_RS06855 ENOG4105BZU Histidine kinase HPG46_RS06860 ENOG4105I3N Conserved Protein HPG46_RS06875 ENOG4105BZU Histidine kinase HPG46_RS06905 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPG46_RS06910 ENOG4105DZ1 carboxypeptidase HPG46_RS06915 ENOG4108JIC nucleoside recognition domain protein HPG46_RS06925 ENOG4105FE9 pseudouridine synthase HPG46_RS06935 ENOG4107TWT Cytochrome c biogenesis protein HPG46_RS06940 ENOG4105CRE cytochrome C HPG46_RS06945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS06950 ENOG4105BZU Histidine kinase HPG46_RS06955 ENOG4108WBT adenosyltransferase HPG46_RS06960 ENOG41063SB peptidase HPG46_RS06970 ENOG4108SAX Membrane HPG46_RS06985 ENOG4105C9U ATP-dependent DNA helicase RecQ HPG46_RS06990 ENOG4105I7S Abortive infection protein HPG46_RS07000 ENOG4107RGJ metallophosphoesterase HPG46_RS07005 ENOG4107X2D transcriptional regulator, merr family HPG46_RS07010 ENOG4108S6Z Negative regulator of genetic competence HPG46_RS07035 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HPG46_RS07040 ENOG4105HDK L-asparaginase HPG46_RS07075 ENOG4105S2F HPG46_RS07080 ENOG41065D1 HPG46_RS07110 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HPG46_RS07125 ENOG4105XXQ heptaprenyl diphosphate synthase component I HPG46_RS07135 ENOG4105EAH synthase HPG46_RS07155 ENOG4105CIH Imidazole acetol-phosphate transaminase HPG46_RS07160 ENOG41068YB TPR repeat-containing protein HPG46_RS07175 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HPG46_RS07180 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HPG46_RS07185 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit HPG46_RS07215 ENOG4108JYZ YitT family HPG46_RS07220 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HPG46_RS07235 ENOG4105FJR Lmbe family HPG46_RS07240 ENOG4105CPK Glycosyl transferase (Group 1 HPG46_RS07275 ENOG4105DVT helicase HPG46_RS07280 ENOG4105YAC HPG46_RS07300 ENOG4105CSM endonuclease III HPG46_RS07310 ENOG4105BZ4 penicillin-binding protein HPG46_RS07370 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HPG46_RS07380 ENOG4105DVT helicase HPG46_RS07385 ENOG4105CTD carboxy-peptidase HPG46_RS07400 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPG46_RS07410 ENOG4105C2W permease HPG46_RS07415 ENOG4105DHF Membrane HPG46_RS07420 ENOG410890F Dynamin family HPG46_RS07430 ENOG4108W0I acetyltransferase HPG46_RS07440 ENOG4105KHC sulfurtransferase HPG46_RS07465 ENOG4106032 Glutathionylspermidine synthase HPG46_RS07525 ENOG4105CPK Glycosyl transferase (Group 1 HPG46_RS07540 ENOG4108SZE gCN5-related N-acetyltransferase HPG46_RS07560 ENOG41081VK Ribonuclease HPG46_RS07625 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPG46_RS07635 ENOG4107RWR Sodium hydrogen exchanger HPG46_RS07640 ENOG4105CN5 Metallo-Beta-Lactamase HPG46_RS07645 ENOG4108Z5V transcriptional regulator, merr family HPG46_RS07655 ENOG4105H67 Protein of unknown function (DUF421) HPG46_RS07660 ENOG41080C8 DUF218 domain HPG46_RS07715 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HPG46_RS07725 ENOG4107R0U MotA TolQ exbB proton channel HPG46_RS07730 ENOG4105ER2 Ompa motb domain protein HPG46_RS07735 ENOG4107YTP response regulator receiver protein HPG46_RS07740 ENOG4105CBS Chea signal transduction histidine kinase HPG46_RS07745 ENOG4105DD5 Flagellar motor switch protein HPG46_RS07760 ENOG4105BZU Histidine kinase HPG46_RS07780 ENOG4105E1Q flagellar hook-associated protein HPG46_RS07785 ENOG4105DTJ flagellar hook-associated protein HPG46_RS07790 ENOG4107TPX flagellar hook-associated HPG46_RS07805 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HPG46_RS07810 ENOG4108ZC9 flagellar basal-body rod protein flgc HPG46_RS07820 ENOG4107U2N Flagellar M-ring protein HPG46_RS07825 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPG46_RS07855 ENOG4105BZE flagellar hook protein, FlgE HPG46_RS07870 ENOG4107R88 Chemotaxis protein (CheV) HPG46_RS07910 ENOG4105I03 Flagellin HPG46_RS07915 ENOG4105E4C Lytic transglycosylase catalytic HPG46_RS07925 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPG46_RS07930 ENOG4105DD5 Flagellar motor switch protein HPG46_RS07940 ENOG4105CN7 Flagellar biosynthetic protein FliP HPG46_RS07945 ENOG4105VS8 Flagellar biosynthetic protein fliq HPG46_RS07955 ENOG4105D00 flagellar biosynthetic protein flhB HPG46_RS07960 ENOG4105D7B Flagellar biosynthesis protein flha HPG46_RS07965 ENOG4105FZW flagellar biosynthesis regulator FlhF HPG46_RS07970 ENOG4105KTQ flagellar basal-body rod protein HPG46_RS07975 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPG46_RS08000 ENOG41062JF Transcriptional regulator HPG46_RS08020 ENOG4105KAC Antibiotic biosynthesis monooxygenase HPG46_RS08050 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPG46_RS08055 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPG46_RS08060 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HPG46_RS08065 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HPG46_RS08120 ENOG4105CVJ phosphoglycerate mutase HPG46_RS08150 ENOG4105CAQ asparagine synthetase HPG46_RS08170 ENOG4105PGM cation diffusion facilitator family transporter HPG46_RS08180 ENOG4105DRR Transcriptional regulator, GntR family HPG46_RS08185 ENOG4108UZ3 Transporter HPG46_RS08190 ENOG4105CKI cobalamin synthesis protein HPG46_RS08195 ENOG4108PJD permease HPG46_RS08210 ENOG4105DFD Na H antiporter HPG46_RS08215 ENOG4105C9Q fumarate hydratase class II HPG46_RS08230 ENOG4105C5X domain protein HPG46_RS08240 ENOG4107QJQ Mate efflux family protein HPG46_RS08245 ENOG4105EC3 peptidase S51, dipeptidase E HPG46_RS08265 ENOG4107QIV Cytochrome c biogenesis protein HPG46_RS08295 ENOG4106BRA Membrane HPG46_RS08330 ENOG4105CJ1 ABC, transporter HPG46_RS08350 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HPG46_RS08360 ENOG4108IJ0 Aspartate ammonia-lyase HPG46_RS08365 ENOG4105C6K Malic enzyme HPG46_RS08400 ENOG41067QW Transcriptional regulator HPG46_RS08420 ENOG4105FVX HPG46_RS08460 ENOG4105CSR polyphosphate kinase 2 HPG46_RS08465 ENOG4105U3E Transcriptional regulator HPG46_RS08475 ENOG4105DXI Major Facilitator superfamily HPG46_RS08490 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPG46_RS08500 ENOG4105EU0 Major facilitator Superfamily HPG46_RS08505 ENOG4105C6T cysteine synthase HPG46_RS08525 ENOG4105C8J )-transporter HPG46_RS08535 ENOG4105X5K response regulator receiver protein HPG46_RS08540 ENOG4105H67 Protein of unknown function (DUF421) HPG46_RS08555 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HPG46_RS08560 ENOG4105CHR reductase HPG46_RS08565 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPG46_RS08570 ENOG4105C7K acetolactate synthase HPG46_RS08575 ENOG4108ZP8 Acetolactate synthase small subunit HPG46_RS08580 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HPG46_RS08590 ENOG4105C7B Threonine dehydratase HPG46_RS08615 ENOG4105C6X Major Facilitator HPG46_RS08620 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HPG46_RS08630 ENOG4107X42 5-methylthioadenosine S-adenosylhomocysteine nucleosidase HPG46_RS08635 ENOG4105DY9 regulatoR HPG46_RS08640 ENOG4105CYC Transferase HPG46_RS08660 ENOG4105F6J Alpha beta hydrolase fold HPG46_RS08705 ENOG41068WN HPG46_RS08725 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HPG46_RS08740 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HPG46_RS08745 ENOG4105C0X amino acid HPG46_RS08770 ENOG4107RHR regulatoR HPG46_RS08780 ENOG4105D9N nucleoside HPG46_RS08785 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HPG46_RS08820 ENOG4107RAQ aminopeptidase HPG46_RS08825 ENOG4107R16 Multicopper oxidase HPG46_RS08870 ENOG4108T5E Copper resistance protein HPG46_RS08875 ENOG4105KTB nuclear export factor GLE1 HPG46_RS08885 ENOG4107RT3 EamA-like transporter family HPG46_RS08890 ENOG4105GZI Transcriptional regulator HPG46_RS08895 ENOG4108Z40 Transcriptional regulator HPG46_RS08900 ENOG4107ZXU DSBA oxidoreductase HPG46_RS08905 ENOG4108TVJ Nitroreductase HPG46_RS08915 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPG46_RS08920 ENOG4106F5Q Membrane HPG46_RS08935 ENOG4105CKI cobalamin synthesis protein HPG46_RS08955 ENOG4108Z7G MaoC domain protein dehydratase HPG46_RS08960 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPG46_RS08970 ENOG4105C0Z ABC transporter HPG46_RS08975 ENOG4108IV0 ABC, transporter HPG46_RS08980 ENOG4105C32 Amino acid ABC transporter (Permease) HPG46_RS08990 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family HPG46_RS09020 ENOG4105C4M (Ubiquinol oxidase) subunit I HPG46_RS09025 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPG46_RS09030 ENOG4108JJ9 ABC, transporter HPG46_RS09035 ENOG4108JJ8 (ABC) transporter HPG46_RS09050 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPG46_RS09080 ENOG4105BZ1 (ABC) transporter HPG46_RS09085 ENOG4105EFI regulatoR HPG46_RS09090 ENOG4105BZU Histidine kinase HPG46_RS09105 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HPG46_RS09115 ENOG4106AKJ HPG46_RS09130 ENOG4105D6E homoserine dehydrogenase HPG46_RS09155 ENOG4108KGH TRANSCRIPTIONal HPG46_RS09165 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_RS09170 ENOG4105BZU Histidine kinase HPG46_RS09185 ENOG4105KT7 mgtC SapB transporter HPG46_RS09190 ENOG4105VRR gCN5-related N-acetyltransferase HPG46_RS09200 ENOG4105DUU IucA IucC family protein HPG46_RS09205 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_RS09220 ENOG4108WBH protein TIM barrel HPG46_RS09225 ENOG4105YWU small acid-soluble spore protein HPG46_RS09235 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HPG46_RS09285 ENOG4105KRN Transcriptional regulator, abrb family HPG46_RS09295 ENOG4105YVS arsR family transcriptional regulator HPG46_RS09300 ENOG4107SET aldo keto reductase HPG46_RS09305 ENOG4107XZQ multidrug resistance protein HPG46_RS09330 ENOG4105C8Q Methyl-accepting chemotaxis HPG46_RS09345 ENOG4108K88 Membrane HPG46_RS09350 ENOG4108WPJ Ferritin-like domain HPG46_RS09365 ENOG4105DEN Luciferase family HPG46_RS09385 ENOG4107QM2 Aldo Keto reductase HPG46_RS09390 ENOG4105CKI cobalamin synthesis protein HPG46_RS09410 ENOG4108IBT Inherit from COG: transposase HPG46_RS09415 ENOG4105DSE periplasmic solute binding protein HPG46_RS09425 ENOG4105K4T epimerase HPG46_RS09435 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPG46_RS09460 ENOG4105CVJ phosphoglycerate mutase HPG46_RS09480 ENOG4107T5V SNARE associated Golgi HPG46_RS09495 ENOG4108PJD permease HPG46_RS09505 ENOG4108S4H thioesterase Superfamily protein HPG46_RS09515 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HPG46_RS09535 ENOG4105SXS Protein of unknown function (DUF456) HPG46_RS09540 ENOG4105C37 (CBS) domain HPG46_RS09560 ENOG4108Z7R Chaperone CsaA HPG46_RS09580 ENOG4108ZRV stage ii sporulation protein p HPG46_RS09590 ENOG4108VXD carboxy-peptidase HPG46_RS09600 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPG46_RS09620 ENOG4105EFA 4-hydroxyphenylacetate HPG46_RS09630 ENOG4105U1N riboflavin HPG46_RS09645 ENOG4105KME endoribonuclease L-psp HPG46_RS09655 ENOG4105IKQ hydratase HPG46_RS09675 ENOG41069HH 4-oxalocrotonate tautomerase HPG46_RS09685 ENOG4108X4Q Hydrolase HPG46_RS09695 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPG46_RS09715 ENOG41087PP glycosyltransferase MGT family HPG46_RS09720 ENOG4108JYZ YitT family HPG46_RS09725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPG46_RS09755 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HPG46_RS09780 ENOG4105KBJ sporulation protein ytfj HPG46_RS09805 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HPG46_RS09825 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HPG46_RS09830 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HPG46_RS09840 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPG46_RS09845 ENOG4105EMN RNA polymerase sigma factor HPG46_RS09860 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HPG46_RS09880 ENOG4108V06 Glutathione peroxidase HPG46_RS09895 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPG46_RS09915 ENOG4108IUE nitrate reductase beta subunit HPG46_RS09920 ENOG4105R3A Nitrate reductase HPG46_RS09930 ENOG4107V6Q Cyclic nucleotide-binding domain HPG46_RS09935 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPG46_RS09940 ENOG4105D06 uba thif-type nad fad binding protein HPG46_RS09945 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPG46_RS09950 ENOG4108ZAF Molybdopterin HPG46_RS09975 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HPG46_RS09980 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HPG46_RS09985 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HPG46_RS09990 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HPG46_RS09995 ENOG4108IFG nitrite reductase, (NAD(P)H) HPG46_RS10000 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HPG46_RS10025 ENOG4105MCT stage V sporulation protein S HPG46_RS10065 ENOG4105C5H ABC transporter HPG46_RS10080 ENOG4108UUM single-stranded DNA-binding protein HPG46_RS10100 ENOG4107YX5 Pfam:DUF548 HPG46_RS10130 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HPG46_RS10150 ENOG4105C5S asparaginyl-tRNA synthetase HPG46_RS10170 ENOG4105EC2 ftsk spoIIIe HPG46_RS10280 ENOG4105BZW Glycerate kinase HPG46_RS10285 ENOG4107QPK )-transporter HPG46_RS10290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS10295 ENOG41062D9 Histidine kinase HPG46_RS10310 ENOG4105C8J )-transporter HPG46_RS10330 ENOG4107XGZ Hydrolase HPG46_RS10335 ENOG4105CY2 Citrate transporter HPG46_RS10340 ENOG4105C0A alcohol dehydrogenase HPG46_RS10355 ENOG4105KD7 acetyltransferase HPG46_RS10360 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HPG46_RS10385 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 HPG46_RS10405 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) HPG46_RS10425 ENOG4107RVG penicillin-binding protein HPG46_RS10435 ENOG4105E9Q Acyl-transferase HPG46_RS10440 ENOG4108UT2 hemolysin iii HPG46_RS10450 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HPG46_RS10460 ENOG4108RCR degv family HPG46_RS10470 ENOG4108KF3 Electron transport protein SCO1 SenC HPG46_RS10475 ENOG4107Y70 Heat shock protein HPG46_RS10480 ENOG4105CAQ asparagine synthetase HPG46_RS10495 ENOG4108MES Periplasmic binding protein HPG46_RS10500 ENOG4105F0I Aminotransferase HPG46_RS10530 ENOG4107Y70 Heat shock protein HPG46_RS10535 ENOG4105D8X mechanosensitive ion channel HPG46_RS10540 ENOG4105BZU Histidine kinase HPG46_RS10545 ENOG4105WH1 Two component transcriptional regulator luxr family HPG46_RS10580 ENOG4105CMG Carbohydrate kinase HPG46_RS10585 ENOG4105CMG Carbohydrate kinase HPG46_RS10615 ENOG4108IJ8 ABC transporter HPG46_RS10620 ENOG4105E90 ABC transporter HPG46_RS10655 ENOG4105C37 (CBS) domain HPG46_RS10680 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPG46_RS10695 ENOG4107S4Y M20 DapE family protein YgeY HPG46_RS10700 ENOG4108TSC N-acetyltransferase HPG46_RS10705 ENOG4108JUB Transcriptional regulator HPG46_RS10710 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HPG46_RS10750 ENOG4108N23 SpoOM-related protein HPG46_RS10755 ENOG410841Q phosphoesterase PA-phosphatase related protein HPG46_RS10765 ENOG4105SZ6 Thioredoxin HPG46_RS10825 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HPG46_RS10875 ENOG4105BZ4 penicillin-binding protein HPG46_RS10880 ENOG4105CZM Major Facilitator HPG46_RS10885 ENOG4105W8X HesB YadR YfhF-family protein HPG46_RS10895 ENOG4105DXD 2-methylcitrate dehydratase HPG46_RS10900 ENOG4105CR4 methylisocitrate lyase HPG46_RS10905 ENOG4105C1G acyl-Coa dehydrogenase HPG46_RS10910 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPG46_RS10920 ENOG4105N14 lysine exporter protein LysE YggA HPG46_RS10925 ENOG4105E39 Enoyl-CoA hydratase HPG46_RS10940 ENOG4107RFY SbcCD D subunit HPG46_RS10945 ENOG4105EYH Exonuclease HPG46_RS10960 ENOG4105FCD Major Facilitator HPG46_RS10965 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HPG46_RS10970 ENOG4105E4F Isochorismate synthase HPG46_RS10975 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HPG46_RS10980 ENOG4105WQI isochorismatase HPG46_RS10985 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_RS10990 ENOG4105WQT MbtH domain protein HPG46_RS10995 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_RS11010 ENOG4105K70 DNA-binding protein HPG46_RS11030 ENOG4105BZG amino acid carrier protein HPG46_RS11050 ENOG4105FE9 pseudouridine synthase HPG46_RS11055 ENOG4105C22 threonyL-tRNA synthetase HPG46_RS11060 ENOG4105C19 ABC transporter HPG46_RS11070 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HPG46_RS11095 ENOG4108D32 Methyltransferase HPG46_RS11115 ENOG41081I9 integral membrane protein HPG46_RS11125 ENOG4108Y4K DNA-binding transcriptional activator HPG46_RS11140 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPG46_RS11150 ENOG4105EYF MMPL domain protein HPG46_RS11175 ENOG4105WCN acetyltransferase HPG46_RS11205 ENOG4105C1Q protoporphyrinogen oxidase HPG46_RS11215 ENOG41068WN HPG46_RS11225 ENOG4105VEQ Cold shock protein HPG46_RS11245 ENOG410667J hydrolase HPG46_RS11295 ENOG4107V2S Transcriptional regulator HPG46_RS11300 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPG46_RS11315 ENOG4105DND Transcriptional regulator HPG46_RS11320 ENOG4108RPX mosc domain containing protein HPG46_RS11335 ENOG4105BZ1 (ABC) transporter HPG46_RS11340 ENOG4105BZ1 (ABC) transporter HPG46_RS11360 ENOG4108JCI Transcriptional regulator HPG46_RS11390 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPG46_RS11400 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HPG46_RS11405 ENOG4108KPJ rna polymerase sigma factor HPG46_RS11430 ENOG4105F32 YngK protein HPG46_RS11455 ENOG4105RD7 BadF BadG BcrA BcrD HPG46_RS11465 ENOG4107STF Involved in phosphonate degradation (By similarity) HPG46_RS11490 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPG46_RS11505 ENOG4105C1J atp-dependent rna helicase HPG46_RS11520 ENOG4108RZE Tetr family transcriptional regulator HPG46_RS11540 ENOG41088CC tellurite resistance protein tehB HPG46_RS11550 ENOG4107RA9 decarboxylase HPG46_RS11555 ENOG41090HR transcriptional regulator HPG46_RS11595 ENOG4105CIN aminoacyl-histidine dipeptidase HPG46_RS11620 ENOG4107RF6 penicillin-binding protein HPG46_RS11625 ENOG4107RF6 penicillin-binding protein HPG46_RS11635 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPG46_RS11640 ENOG4105ETE Transcriptional regulator (LacI family HPG46_RS11645 ENOG4105IE8 Alpha-ketoglutarate permease HPG46_RS11650 ENOG4105CK5 oxidoreductase HPG46_RS11675 ENOG4105D2N Aldolase HPG46_RS11680 ENOG4105DH8 myo-inositol catabolism HPG46_RS11690 ENOG4105CGH 5'-nucleotidase HPG46_RS11715 ENOG4108VXD carboxy-peptidase HPG46_RS11730 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity HPG46_RS11735 ENOG41067SE Tetr family transcriptional regulator HPG46_RS11740 ENOG4105C5H ABC transporter HPG46_RS11750 ENOG4105BZU Histidine kinase HPG46_RS11810 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HPG46_RS11840 ENOG4105C1G acyl-Coa dehydrogenase HPG46_RS11845 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPG46_RS11850 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HPG46_RS11855 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HPG46_RS11860 ENOG4105E39 Enoyl-CoA hydratase HPG46_RS11865 ENOG4107QX3 carboxylase HPG46_RS11870 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPG46_RS11880 ENOG4105WCN acetyltransferase HPG46_RS11885 ENOG4105DBI uridine monophosphokinase HPG46_RS11895 ENOG4105DZ1 carboxypeptidase HPG46_RS11910 ENOG4105T9C HD domain HPG46_RS11920 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HPG46_RS11960 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPG46_RS11975 ENOG4105FQP Beta-lactamase HPG46_RS11985 ENOG4107Y80 Major Facilitator superfamily HPG46_RS12005 ENOG4105CUV Homoserine Kinase HPG46_RS12045 ENOG4105CPQ Dehydrogenase HPG46_RS12065 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HPG46_RS12075 ENOG4105DK7 lysyl-tRNA synthetase HPG46_RS12145 ENOG4105D6E homoserine dehydrogenase HPG46_RS12160 ENOG4105ETU transcriptional activator (TenA HPG46_RS12185 ENOG4105VTR Integrase HPG46_RS12535 ENOG410667J hydrolase HPG46_RS12540 ENOG4105BZU Histidine kinase HPG46_RS12545 ENOG4107RF6 penicillin-binding protein HPG46_RS12565 ENOG4108JJB ABC transporter HPG46_RS12580 ENOG4108HGU Histidine kinase HPG46_RS12590 ENOG4105RHY Pfam:UPF0157 HPG46_RS12595 ENOG4105CB2 alcohol dehydrogenase HPG46_RS12600 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPG46_RS12605 ENOG4105CJN penicillin-binding protein HPG46_RS12615 ENOG4105FQP Beta-lactamase HPG46_RS12670 ENOG4107Y80 Major Facilitator superfamily HPG46_RS12685 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HPG46_RS12705 ENOG4107Y9U Membrane HPG46_RS12745 ENOG4105FCD Major Facilitator HPG46_RS12760 ENOG4105E09 nadh pyrophosphatase HPG46_RS12765 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPG46_RS12770 ENOG4108Z4K mutator MutT protein HPG46_RS12800 ENOG4108XI2 Domain of unknown function (DUF1963) HPG46_RS12820 ENOG4108NRW Phospholipase, patatin family HPG46_RS12825 ENOG4105KWG Pfam:DUF1696 HPG46_RS12860 ENOG4105PKS Excinuclease abc c subunit domain protein HPG46_RS12900 ENOG4107VFR oxidoreductase HPG46_RS12945 ENOG4108IUM Glycogen debranching enzyme HPG46_RS12970 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPG46_RS12980 ENOG4105FDR Membrane HPG46_RS13040 ENOG4105MSI germination protein ypeb HPG46_RS13065 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HPG46_RS13070 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HPG46_RS13075 ENOG4107Z3H Transcriptional regulator, TetR family HPG46_RS13105 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HPG46_RS13125 ENOG4105E98 transcriptional regulator DeoR family HPG46_RS13150 ENOG4107QKR Dehydrogenase HPG46_RS13160 ENOG4107RUY (E1 component), alpha subunit HPG46_RS13170 ENOG4105E1F short-chain dehydrogenase reductase HPG46_RS13175 ENOG4105RHY Pfam:UPF0157 HPG46_RS13185 ENOG4108TIT dATP pyrophosphohydrolase HPG46_RS13210 ENOG4107SQ8 Glycine betaine HPG46_RS13215 ENOG4108IJ7 Glycine betaine HPG46_RS13245 ENOG41082BV acetyltransferase HPG46_RS13250 ENOG4108M1A Chitin-binding protein HPG46_RS13270 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPG46_RS13285 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HPG46_RS13315 ENOG4108Z7F N-acetyltransferase HPG46_RS13335 ENOG4105EEM helicase HPG46_RS13355 ENOG4105C9U ATP-dependent DNA helicase RecQ HPG46_RS13405 ENOG4108M1A Chitin-binding protein HPG46_RS13425 ENOG4105BZG amino acid carrier protein HPG46_RS13430 ENOG4105C26 Dehydrogenase HPG46_RS13435 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPG46_RS13440 ENOG4105CTU Proline racemase HPG46_RS13445 ENOG4105CTU Proline racemase HPG46_RS13450 ENOG41080HI glycine oxidase HPG46_RS13460 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HPG46_RS13500 ENOG4105DCI Phosphohydrolase HPG46_RS13505 ENOG4107T5V SNARE associated Golgi HPG46_RS13520 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HPG46_RS13525 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPG46_RS13540 ENOG4105DTQ mandelate racemase muconate lactonizing HPG46_RS13580 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HPG46_RS13585 ENOG4105BZU Histidine kinase HPG46_RS13590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS13625 ENOG4105DPN Oligoendopeptidase f HPG46_RS13640 ENOG4105EPR degv family HPG46_RS13695 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HPG46_RS13700 ENOG4106K7D Major facilitator family transporter HPG46_RS13720 ENOG4107BMA Transglycosylase associated protein HPG46_RS13735 ENOG41089UC methyltransferase, type 11 HPG46_RS13770 ENOG4105CHM Aminotransferase HPG46_RS13785 ENOG4108ZMI UPF0477 protein HPG46_RS13845 ENOG4105C02 permease HPG46_RS13855 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HPG46_RS13860 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HPG46_RS13865 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HPG46_RS13890 ENOG4105E09 nadh pyrophosphatase HPG46_RS13910 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HPG46_RS13960 ENOG4107VC0 DNA alkylation repair enzyme HPG46_RS13980 ENOG4108ZCF integral membrane protein HPG46_RS13985 ENOG4105E0M Sulfatase HPG46_RS13990 ENOG4105C5H ABC transporter HPG46_RS14000 ENOG4105EYF MMPL domain protein HPG46_RS14005 ENOG41082JN Transcriptional regulator HPG46_RS14025 ENOG4105CIH Imidazole acetol-phosphate transaminase HPG46_RS14035 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HPG46_RS14055 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) HPG46_RS14070 ENOG41069ER domain protein HPG46_RS14080 ENOG4105EMN RNA polymerase sigma factor HPG46_RS14105 ENOG4105D4B ABC, transporter HPG46_RS14115 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HPG46_RS14125 ENOG4105DKT Transcriptional regulator HPG46_RS14130 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HPG46_RS14140 ENOG41061GT Aldolase HPG46_RS14160 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HPG46_RS14190 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HPG46_RS14195 ENOG4105II7 pyrroline-5-carboxylate reductase HPG46_RS14205 ENOG4107258 Transcriptional regulator HPG46_RS14220 ENOG4105ECK Fatty Acid Desaturase HPG46_RS14225 ENOG4105G6Z alkaline phosphatase HPG46_RS14235 ENOG4105VMP Transcriptional regulator HPG46_RS14250 ENOG41090T1 Membrane HPG46_RS14260 ENOG4108WCX response regulator HPG46_RS14270 ENOG41068WN HPG46_RS14295 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPG46_RS14310 ENOG4105CSH Transporter HPG46_RS14320 ENOG4105CKK Glycosyl transferase, family 2 HPG46_RS14335 ENOG4105CKK Glycosyl transferase, family 2 HPG46_RS14345 ENOG4105C8Y Acetylornithine aminotransferase HPG46_RS14385 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPG46_RS14395 ENOG4108TVJ Nitroreductase HPG46_RS14400 ENOG4105FS7 Transcriptional regulator HPG46_RS14420 ENOG4105ERH Fumarylacetoacetate hydrolase HPG46_RS14440 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_RS14445 ENOG4105CHU acetyl-coa acetyltransferase HPG46_RS14450 ENOG4105E39 Enoyl-CoA hydratase HPG46_RS14455 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPG46_RS14460 ENOG4105CS2 ec 3.2.1.21 HPG46_RS14465 ENOG4105VCP PTS System HPG46_RS14470 ENOG4108QVC Component IIC HPG46_RS14485 ENOG4105VZJ PTS System HPG46_RS14495 ENOG4105G9B Transcriptional regulator HPG46_RS14500 ENOG4105D2S major facilitator superfamily HPG46_RS14505 ENOG4105EFZ amidohydrolase HPG46_RS14535 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HPG46_RS14545 ENOG4105C19 ABC transporter HPG46_RS14575 ENOG4108XET gCN5-related N-acetyltransferase HPG46_RS14645 ENOG410635A Membrane HPG46_RS14650 ENOG4105KNA -acetyltransferase HPG46_RS14655 ENOG4108IQI permease HPG46_RS14665 ENOG4105F1N DNA alkylation repair HPG46_RS14695 ENOG4107RF6 penicillin-binding protein HPG46_RS14730 ENOG4105P4J Allophanate hydrolase, subunit 1 HPG46_RS14735 ENOG4107258 Transcriptional regulator HPG46_RS14750 ENOG4106N3A copper homeostasis protein cutc HPG46_RS14755 ENOG4108ZRV stage ii sporulation protein p HPG46_RS14760 ENOG4108ZHR arsR family transcriptional regulator HPG46_RS14770 ENOG4105FDT acyl-CoA dehydrogenase HPG46_RS14785 ENOG4105DWD nucleoside recognition domain protein HPG46_RS14815 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HPG46_RS14880 ENOG4105E2A Dehydrogenase HPG46_RS14890 ENOG4108IJ0 Aspartate ammonia-lyase HPG46_RS14895 ENOG4105HDK L-asparaginase HPG46_RS14900 ENOG4108IMY Transcriptional regulator HPG46_RS14915 ENOG4105CUB amino acid HPG46_RS14925 ENOG4105II7 pyrroline-5-carboxylate reductase HPG46_RS14955 ENOG4105CSV Glutaminase HPG46_RS15005 ENOG4107QJQ Mate efflux family protein HPG46_RS15015 ENOG4107QTZ amino acid HPG46_RS15025 ENOG4105CH6 catalase HPG46_RS15035 ENOG4105CHJ isochorismatase hydrolase HPG46_RS15060 ENOG41090MY MarR family Transcriptional regulator HPG46_RS15095 ENOG4108606 TspO/MBR family HPG46_RS15100 ENOG4105CVP deoxyribo-dipyrimidine photolyase HPG46_RS15115 ENOG4108TWJ NADH dehydrogenase subunit 5 HPG46_RS15120 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HPG46_RS15135 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPG46_RS15145 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HPG46_RS15200 ENOG4105D6J arsenicaL-resistance protein HPG46_RS15205 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HPG46_RS15210 ENOG41085FC arsR family transcriptional regulator HPG46_RS15230 ENOG4105BZU Histidine kinase HPG46_RS15235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS15255 ENOG4108IG5 Transcriptional regulator HPG46_RS15260 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HPG46_RS15340 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HPG46_RS15345 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_RS15355 ENOG4105IIP Membrane HPG46_RS15370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS15375 ENOG41062D9 Histidine kinase HPG46_RS15400 ENOG4105K6H D-cysteine desulfhydrase HPG46_RS15425 ENOG4108NNI Beta-lactamase domain-containing protein HPG46_RS15430 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HPG46_RS15440 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPG46_RS15445 ENOG4105JQZ Methyltransferase HPG46_RS15465 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HPG46_RS15480 ENOG4105BZU Histidine kinase HPG46_RS15490 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HPG46_RS15495 ENOG4105DJB Major Facilitator Superfamily HPG46_RS15505 ENOG4107QR9 Iron-sulfur cluster binding protein HPG46_RS15515 ENOG4106P55 Transcriptional regulator HPG46_RS15535 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPG46_RS15550 ENOG4108JQ1 Dehydrogenase HPG46_RS15570 ENOG4108AEY RNA polymerase sigma factor HPG46_RS15585 ENOG41082W1 Cupin 2, conserved barrel domain protein HPG46_RS15590 ENOG410874W AraC family transcriptional regulator HPG46_RS15605 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HPG46_RS15645 ENOG4108ISG Major Facilitator HPG46_RS15655 ENOG4107MII Sugar-specific transcriptional regulator TrmB HPG46_RS15660 ENOG4105CZM Major Facilitator HPG46_RS15675 ENOG4105DA5 (ABC) transporter HPG46_RS15680 ENOG41069JR HPG46_RS15690 ENOG4105RXJ HPG46_RS15695 ENOG4105KPY Small multidrug resistance protein HPG46_RS15700 ENOG4105KBX Transcriptional regulator, TetR family HPG46_RS15705 ENOG4107AUC HPG46_RS15715 ENOG4105CRW Short chain fatty acid transporter HPG46_RS15725 ENOG4105DYS nad(p)h dehydrogenase (quinone) HPG46_RS15755 ENOG4108JJB ABC transporter HPG46_RS15760 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HPG46_RS15785 ENOG4108K8S endonuclease I HPG46_RS15800 ENOG41067QW Transcriptional regulator HPG46_RS15810 ENOG4108Z66 YbaK ebsC protein HPG46_RS15830 ENOG4105KVH Transcriptional regulator HPG46_RS15835 ENOG4108RCM Nitroreductase HPG46_RS15855 ENOG4108PSK reductase HPG46_RS15865 ENOG4105CJ1 ABC, transporter HPG46_RS15925 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HPG46_RS15930 ENOG4105DKQ ROK family HPG46_RS15935 ENOG4106UW1 Major Facilitator superfamily HPG46_RS15940 ENOG4108UW5 maltose o-acetyltransferase HPG46_RS15975 ENOG4105DMQ Methyltransferase HPG46_RS15985 ENOG4105EV4 Multidrug resistance protein mdtH HPG46_RS16015 ENOG4105C37 (CBS) domain HPG46_RS16030 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HPG46_RS16035 ENOG4105FAW cDP-glucose 4,6-dehydratase HPG46_RS16065 ENOG4105DDN Pentapeptide repeat-containing protein HPG46_RS16070 ENOG4105XDF Protein of unknown function (DUF1272) HPG46_RS16075 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HPG46_RS16080 ENOG4105CMG Carbohydrate kinase HPG46_RS16085 ENOG4105C6Z Gluconate HPG46_RS16090 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPG46_RS16105 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HPG46_RS16110 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HPG46_RS16115 ENOG4105CIS alcohol dehydrogenase HPG46_RS16120 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HPG46_RS16135 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HPG46_RS16140 ENOG4105D4Y metalloprotease HPG46_RS16150 ENOG4108UX3 '-nucleotidase HPG46_RS16155 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPG46_RS16160 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HPG46_RS16165 ENOG4105KVH Transcriptional regulator HPG46_RS16180 ENOG4105CV8 reductase HPG46_RS16185 ENOG4105F27 Major Facilitator HPG46_RS16200 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HPG46_RS16205 ENOG4105C44 Serine transporter HPG46_RS16240 ENOG4105KVH Transcriptional regulator HPG46_RS16245 ENOG4108TZY GntR Family Transcriptional Regulator HPG46_RS16250 ENOG4105D9R oxidoreductase HPG46_RS16255 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPG46_RS16260 ENOG4105KVH Transcriptional regulator HPG46_RS16265 ENOG4105KVH Transcriptional regulator HPG46_RS16305 ENOG4105JAB phenazine biosynthesis protein, phzf family HPG46_RS16315 ENOG4105CHR reductase HPG46_RS16325 ENOG4105KNA -acetyltransferase HPG46_RS16335 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HPG46_RS16340 ENOG4105KVH Transcriptional regulator HPG46_RS16395 ENOG4105KAF membrAne HPG46_RS16420 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HPG46_RS16435 ENOG4107YXZ hydrolase, family 25 HPG46_RS16470 ENOG4105H3G oxidoreductase HPG46_RS16540 ENOG4108TN2 lmbE family HPG46_RS16550 ENOG4107R3E Citrate transporter HPG46_RS16565 ENOG4108MES Periplasmic binding protein HPG46_RS16570 ENOG4105EHG Permease protein HPG46_RS16575 ENOG4105DQ5 transport system permease protein HPG46_RS16580 ENOG4105NX3 Membrane HPG46_RS16585 ENOG4107ZY0 Phenazine biosynthesis-like protein HPG46_RS16605 ENOG4107CUJ Protein of unknown function (DUF2690) HPG46_RS16615 ENOG4107V2S Transcriptional regulator HPG46_RS16635 ENOG4105C98 muts2 protein HPG46_RS16645 ENOG4105E5K Alpha-amylase HPG46_RS16650 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HPG46_RS16655 ENOG4105DPN Oligoendopeptidase f HPG46_RS16660 ENOG4108A04 Beta-lactamase HPG46_RS16690 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HPG46_RS16715 ENOG41082BM Transcriptional regulator, arsr family HPG46_RS16720 ENOG4105CIS alcohol dehydrogenase HPG46_RS16740 ENOG4105C09 Bile acid HPG46_RS16745 ENOG4105CQB FAD linked oxidase domain protein HPG46_RS16770 ENOG4108UT6 Transferase hexapeptide repeat containing protein HPG46_RS16780 ENOG4105K64 Glycosyl transferase, family 2 HPG46_RS16785 ENOG4105E39 Enoyl-CoA hydratase HPG46_RS16795 ENOG4105KT7 mgtC SapB transporter HPG46_RS16810 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HPG46_RS16815 ENOG41073R8 VanW family HPG46_RS16825 ENOG4108R1P HPG46_RS16845 ENOG4105VEQ Cold shock protein HPG46_RS16865 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HPG46_RS16885 ENOG410904N short-chain dehydrogenase reductase HPG46_RS16895 ENOG4106IQC argininosuccinate lyase HPG46_RS16910 ENOG4108IA2 Sodium pantothenate symporter HPG46_RS16920 ENOG4105C26 Dehydrogenase HPG46_RS16925 ENOG4105CHR reductase HPG46_RS16935 ENOG4105EWU Squalene--hopene cyclase HPG46_RS16945 ENOG4105FR1 rard protein HPG46_RS16950 ENOG410696E Membrane HPG46_RS16965 ENOG4105D1F ATP-binding protein HPG46_RS16975 ENOG4108ZAF Molybdopterin HPG46_RS16980 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPG46_RS16985 ENOG4105D06 uba thif-type nad fad binding protein HPG46_RS16990 ENOG4105TMB Formate nitrite transporter HPG46_RS17000 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HPG46_RS17005 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HPG46_RS17015 ENOG4108JB9 formate dehydrogenase HPG46_RS17020 ENOG4105E1K spore germination protein HPG46_RS17080 ENOG4107QJT sodium dicarboxylate symporter HPG46_RS17085 ENOG4108KGH TRANSCRIPTIONal HPG46_RS17095 ENOG4105EMN RNA polymerase sigma factor HPG46_RS17115 ENOG4105CIG ABC transporter HPG46_RS17125 ENOG4105D9R oxidoreductase HPG46_RS17135 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPG46_RS17140 ENOG4105K4P CoA-binding domain protein HPG46_RS17145 ENOG4105C0H protease HPG46_RS17150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS17160 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HPG46_RS17170 ENOG4105W8X HesB YadR YfhF-family protein HPG46_RS17200 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HPG46_RS17205 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPG46_RS17215 ENOG4105BZ1 (ABC) transporter HPG46_RS17220 ENOG4108I0Z Aconitate hydratase HPG46_RS17260 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPG46_RS17280 ENOG4107F3J Amp-dependent synthetase and ligase HPG46_RS17285 ENOG4107ZYJ bioY protein HPG46_RS17290 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_RS17340 ENOG4107AYK membrAne HPG46_RS17350 ENOG4105BZU Histidine kinase HPG46_RS17355 ENOG4105FBA Phospholipase Carboxylesterase HPG46_RS17360 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HPG46_RS17365 ENOG4105CK7 Sodium proline symporter HPG46_RS17370 ENOG4105CBC glutamate synthase HPG46_RS17375 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPG46_RS17380 ENOG4108VJ1 Transcriptional regulator (CarD family HPG46_RS17385 ENOG4108903 Formimidoylglutamase HPG46_RS17410 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HPG46_RS17450 ENOG4107QIV Cytochrome c biogenesis protein HPG46_RS17470 ENOG4105CJ1 ABC, transporter HPG46_RS17480 ENOG4107RSM transcriptional regulator HPG46_RS17490 ENOG41067MG lrgb family HPG46_RS17515 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HPG46_RS17530 ENOG4105BZ1 (ABC) transporter HPG46_RS17535 ENOG4105BZ1 (ABC) transporter HPG46_RS17575 ENOG4105CGH 5'-nucleotidase HPG46_RS17585 ENOG4108SVB resolvase HPG46_RS17605 ENOG4105K7K Transcriptional regulator HPG46_RS17615 ENOG4105C5F glutamine synthetase HPG46_RS17620 ENOG4105KV4 Transcriptional regulator HPG46_RS17625 ENOG4105CXI aluminum resistance protein HPG46_RS17630 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPG46_RS17635 ENOG4105EN6 Membrane HPG46_RS17640 ENOG4106F1P AAA ATPase, central domain protein HPG46_RS17670 ENOG41069ER domain protein HPG46_RS17675 ENOG4105DM4 PTS System HPG46_RS17680 ENOG4105DE4 1-phosphofructokinase HPG46_RS17685 ENOG4105E98 transcriptional regulator DeoR family HPG46_RS17690 ENOG4107QW4 alcohol dehydrogenase HPG46_RS17695 ENOG4108SJC Membrane HPG46_RS17705 ENOG4105C85 amino acid HPG46_RS17725 ENOG4105TMB Formate nitrite transporter HPG46_RS17730 ENOG4105K70 DNA-binding protein HPG46_RS17740 ENOG4105C59 p-type ATPase HPG46_RS17745 ENOG410681U heavy metal transport detoxification protein HPG46_RS17750 ENOG4105VPX protein, conserved in bacteria HPG46_RS17760 ENOG4105NIV Esterase HPG46_RS17765 ENOG4105E0A ABC, transporter HPG46_RS17785 ENOG4105CGK Exodeoxyribonuclease III HPG46_RS17795 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPG46_RS17800 ENOG4105D03 DNA-3-methyladenine glycosylase II HPG46_RS17830 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HPG46_RS17835 ENOG4105BZU Histidine kinase HPG46_RS17850 ENOG41067MG lrgb family HPG46_RS17865 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HPG46_RS17870 ENOG4107YEI lmbE family HPG46_RS17895 ENOG4105F0V Cell wall hydrolase HPG46_RS17900 ENOG4107R6R udp-galactopyranose mutase HPG46_RS17905 ENOG4105E0M Sulfatase HPG46_RS17910 ENOG410890F Dynamin family HPG46_RS17920 ENOG4107QHE Choloylglycine hydrolase HPG46_RS17950 ENOG4105DQU oxidoreductase, subunit beta HPG46_RS17955 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HPG46_RS17960 ENOG4108IGT Dipeptidase HPG46_RS17965 ENOG4105MCT stage V sporulation protein S HPG46_RS17970 ENOG4105D48 metallophosphoesterase HPG46_RS17995 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HPG46_RS18010 ENOG4105XZV Protein of unknown function (DUF3243) HPG46_RS18015 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HPG46_RS18035 ENOG4105UIB (ABC) transporter HPG46_RS18040 ENOG4108JQ9 ABC transporter HPG46_RS18045 ENOG4105DIH basic membrane HPG46_RS18050 ENOG4105FDP GntR family transcriptional regulator HPG46_RS18055 ENOG4107QZI cell division protein FtsK HPG46_RS18065 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HPG46_RS18075 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPG46_RS18085 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPG46_RS18090 ENOG4108S0H Dipicolinic acid synthetase, b subunit HPG46_RS18095 ENOG4105E35 Dipicolinate synthase subunit A HPG46_RS18105 ENOG4105C1V Peptidase, M16 HPG46_RS18125 ENOG4105DTN riboflavin biosynthesis protein ribF HPG46_RS18130 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HPG46_RS18140 ENOG4105W7A Protein of unknown function (DUF503) HPG46_RS18150 ENOG4105VHM ribosomal protein HPG46_RS18155 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HPG46_RS18160 ENOG4105CHV Transcription elongation factor NusA HPG46_RS18170 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HPG46_RS18180 ENOG4105DZP Membrane-associated zinc metalloprotease HPG46_RS18190 ENOG4105KNE Phosphatidate cytidylyltransferase HPG46_RS18235 ENOG4108HE4 integrase family HPG46_RS18245 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPG46_RS18250 ENOG4105C79 DNA protecting protein DprA HPG46_RS18255 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HPG46_RS18270 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HPG46_RS18295 ENOG4105VB6 UPF0109 protein HPG46_RS18315 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HPG46_RS18320 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HPG46_RS18335 ENOG4105CHR reductase HPG46_RS18340 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HPG46_RS18355 ENOG4105CB5 ATP-dependent DNA helicase recG HPG46_RS18360 ENOG4105DP4 dak2 domain fusion protein ylov HPG46_RS18365 ENOG4108ZAA Alkaline-shock protein HPG46_RS18380 ENOG4105FJ0 thiamine HPG46_RS18385 ENOG4105DJV ribulose-phosphate 3-epimerase HPG46_RS18390 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HPG46_RS18395 ENOG4105D9P serine threonine protein kinase HPG46_RS18400 ENOG4108ZF3 Phosphatase HPG46_RS18410 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HPG46_RS18420 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HPG46_RS18425 ENOG4105C25 Primosomal protein n' HPG46_RS18430 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HPG46_RS18450 ENOG4105DSJ YicC domain protein HPG46_RS18465 ENOG4105DC7 peptidase M24 HPG46_RS18550 ENOG4105C34 Pseudouridine synthase HPG46_RS18575 ENOG4105DBK s4 domain protein HPG46_RS18580 ENOG41067XK integral membrane protein HPG46_RS18590 ENOG4105DFA alanine racemase domain protein HPG46_RS18595 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HPG46_RS18600 ENOG4105WR5 sporulation protein, YlmC YmxH family HPG46_RS18610 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_RS18620 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HPG46_RS18625 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HPG46_RS18630 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HPG46_RS18635 ENOG4105D4A Cell wall formation (By similarity) HPG46_RS18645 ENOG4105CNI cell division protein FtsW HPG46_RS18660 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HPG46_RS18665 ENOG4105CJN penicillin-binding protein HPG46_RS18670 ENOG4105CJN penicillin-binding protein HPG46_RS18675 ENOG41068DC Essential cell division protein (By similarity) HPG46_RS18710 ENOG4105KNH Nucleic acid-binding protein HPG46_RS18720 ENOG41063PX domain protein HPG46_RS18725 ENOG4105D78 K07001 NTE family protein HPG46_RS18730 ENOG4105H20 Sporulation integral membrane protein YlbJ HPG46_RS18740 ENOG4106H78 methyltransferase HPG46_RS18760 ENOG4107TB6 phosphoglycerate mutase HPG46_RS18775 ENOG4106UY4 Inherit from COG: Scp-like extracellular HPG46_RS18825 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HPG46_RS18830 ENOG4105CNI cell division protein FtsW HPG46_RS18845 ENOG4108IAB Phoh family HPG46_RS18865 ENOG4105QA2 HPG46_RS18870 ENOG4105CI3 gtp-binding protein typa HPG46_RS18880 ENOG4105ECY inositol monophosphatase HPG46_RS18900 ENOG4105CXN decarboxylase HPG46_RS18950 ENOG4105CPP Dehydrogenase, E1 component HPG46_RS18965 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HPG46_RS18970 ENOG4108X4Q Hydrolase HPG46_RS18980 ENOG4105CN5 Metallo-Beta-Lactamase HPG46_RS18985 ENOG4107ZYR domain protein HPG46_RS19020 ENOG4108XRC Protein of unknown function (DUF458) HPG46_RS19030 ENOG4107IN1 Protein of unknown function (DUF1797) HPG46_RS19045 ENOG4105EPM Diguanylate phosphodiesterase HPG46_RS19050 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HPG46_RS19065 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HPG46_RS19075 ENOG4105UIN HPG46_RS19130 ENOG4108HGU Histidine kinase HPG46_RS19140 ENOG4105CHM Aminotransferase HPG46_RS19145 ENOG4105FKQ transcriptional regulator HPG46_RS19150 ENOG4105EG2 ABC transporter, permease HPG46_RS19160 ENOG4107FKK extracellular solute-binding protein family 1 HPG46_RS19170 ENOG4105CG3 alpha amylase, catalytic region HPG46_RS19215 ENOG4105CHU acetyl-coa acetyltransferase HPG46_RS19250 ENOG4105K7K Transcriptional regulator HPG46_RS19255 ENOG4105DTD Dehydrogenase HPG46_RS19275 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPG46_RS19315 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPG46_RS19320 ENOG4105BZU Histidine kinase HPG46_RS19340 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPG46_RS19355 ENOG4105CID antiterminator HPG46_RS19375 ENOG4105CE4 GlcNAc 6-P deacetylase HPG46_RS19410 ENOG4107ZE5 PPIases accelerate the folding of proteins HPG46_RS19415 ENOG4105PTM secreted protein HPG46_RS19420 ENOG4105J7I hydrolase HPG46_RS19430 ENOG4105G6R Stage v sporulation protein ae HPG46_RS19440 ENOG4105CZ3 stage V sporulation protein ad HPG46_RS19445 ENOG41090VF Stage v sporulation protein ac HPG46_RS19465 ENOG4105C8J )-transporter HPG46_RS19470 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_RS19480 ENOG41082AN stage II sporulation protein HPG46_RS19485 ENOG4105DZ1 carboxypeptidase HPG46_RS19490 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HPG46_RS19495 ENOG4105DVE abc transporter atp-binding protein HPG46_RS19525 ENOG4105D7N magnesium and cobalt transport protein CorA HPG46_RS19550 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPG46_RS19560 ENOG4105I3K Ferric uptake regulator, Fur family HPG46_RS19565 ENOG4105MZ9 stage II sporulation protein m HPG46_RS19585 ENOG4105CPC Aldo Keto reductase HPG46_RS19595 ENOG4105RHY Pfam:UPF0157 HPG46_RS19615 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HPG46_RS19625 ENOG4105ETE Transcriptional regulator (LacI family HPG46_RS19630 ENOG4108YM7 Gcn5-related n-acetyltransferase HPG46_RS19650 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPG46_RS19655 ENOG4108R6K riboflavin synthase, subunit alpha HPG46_RS19680 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPG46_RS19685 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPG46_RS19700 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPG46_RS19710 ENOG4105DFD Na H antiporter HPG46_RS19715 ENOG4105CGH 5'-nucleotidase HPG46_RS19755 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HPG46_RS19770 ENOG4108IXY short-chain dehydrogenase reductase HPG46_RS19775 ENOG41069FQ Metallo-beta-lactamase superfamily HPG46_RS19780 ENOG4105II7 pyrroline-5-carboxylate reductase HPG46_RS19785 ENOG4105EJQ L-serine dehydratase HPG46_RS19810 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HPG46_RS19820 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HPG46_RS19825 ENOG4105D9U N-acetyltransferase HPG46_RS19840 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HPG46_RS19845 ENOG4108QEG Membrane HPG46_RS19850 ENOG4105CDA abc transporter atp-binding protein HPG46_RS19855 ENOG4105E5Q amino acid AbC transporter HPG46_RS19860 ENOG4108HW3 (ABC) transporter HPG46_RS19870 ENOG4105G7B Protein of unknown function (DUF2992) HPG46_RS19875 ENOG4105E09 nadh pyrophosphatase HPG46_RS19885 ENOG4105C7S Dehydrogenase HPG46_RS19890 ENOG4105CPP Dehydrogenase, E1 component HPG46_RS19910 ENOG4107RDP Dehydrogenase HPG46_RS19920 ENOG4108JUB Transcriptional regulator HPG46_RS19930 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HPG46_RS19945 ENOG4107QQR Sporulation HPG46_RS19950 ENOG4105S1Z Stage IV sporulation protein B HPG46_RS19955 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HPG46_RS19965 ENOG4105DX0 Hemolysin A HPG46_RS19975 ENOG4105CTB Polyprenyl synthetase HPG46_RS20000 ENOG4108ZSR alkaline shock protein HPG46_RS20005 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPG46_RS20030 ENOG410644B Stage III sporulation protein af HPG46_RS20040 ENOG4105KQ4 Stage iii sporulation protein ad HPG46_RS20045 ENOG4108CQH stage III sporulation protein AC HPG46_RS20050 ENOG4105KR5 Stage iii sporulation protein HPG46_RS20055 ENOG4105CD2 stage iii sporulation protein aa HPG46_RS20080 ENOG4105DC7 peptidase M24 HPG46_RS20095 ENOG4105CBJ Metal-dependent enzyme HPG46_RS20105 ENOG4107YBY Hydrolase HPG46_RS20135 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HPG46_RS20140 ENOG4105WZW rhodanese family HPG46_RS20160 ENOG41080TC multidrug resistance protein HPG46_RS20195 ENOG4105CJ1 ABC, transporter HPG46_RS20200 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HPG46_RS20230 ENOG4105C0D helicase HPG46_RS20345 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HPG46_RS20350 ENOG4105C3R Methionine synthase HPG46_RS20360 ENOG4105C28 cystathionine HPG46_RS20365 ENOG4105C28 cystathionine HPG46_RS20385 ENOG4105C5X domain protein HPG46_RS20395 ENOG4105DKQ ROK family HPG46_RS20405 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HPG46_RS20420 ENOG4108UTW Plays a role in the regulation of phosphate uptake HPG46_RS20430 ENOG4105E2Z phosphate ABC transporter (Permease HPG46_RS20435 ENOG4105C8U phosphate abc transporter HPG46_RS20440 ENOG4105PWN phosphate abc transporter HPG46_RS20445 ENOG4107RF6 penicillin-binding protein HPG46_RS20455 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPG46_RS20480 ENOG4105N80 Ferric uptake regulator, Fur family HPG46_RS20490 ENOG4105FDK ABC transporter HPG46_RS20495 ENOG4108JYZ YitT family HPG46_RS20500 ENOG41069ZM Protein of unknown function (DUF2624) HPG46_RS20525 ENOG4105EGD dinuclear metal center protein, YbgI family HPG46_RS20540 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_RS20545 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HPG46_RS20570 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HPG46_RS20575 ENOG4105KG3 cytidine deaminase HPG46_RS20580 ENOG4107YR5 Diacylglycerol kinase HPG46_RS20590 ENOG4105CTJ Metal Dependent Phosphohydrolase HPG46_RS20595 ENOG4105C9A Phoh family HPG46_RS20605 ENOG41068P3 sporulation protein YqfC HPG46_RS20610 ENOG4105KTH gatB Yqey HPG46_RS20620 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HPG46_RS20625 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPG46_RS20655 ENOG4105CSA Coproporphyrinogen iii oxidase HPG46_RS20660 ENOG4105KVH Transcriptional regulator HPG46_RS20685 ENOG4105TQK DNA polymerase iii, delta' subunit HPG46_RS20695 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HPG46_RS20700 ENOG4108UK2 deaminase HPG46_RS20705 ENOG4105KQC Competence protein HPG46_RS20715 ENOG4105DXX methyltransferase HPG46_RS20725 ENOG4108WF2 Metal Dependent Phosphohydrolase HPG46_RS20735 ENOG410812S Rna-binding protein HPG46_RS20745 ENOG4105CQW ribosome biogenesis GTPase YqeH HPG46_RS20750 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HPG46_RS20765 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_RS20785 ENOG4108TVJ Nitroreductase HPG46_RS20800 ENOG4105G6Z alkaline phosphatase HPG46_RS20810 ENOG4108MUZ hydrolase HPG46_RS20845 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_RS20850 ENOG4105MIR Phenylalanine 4-monooxygenase HPG46_RS20860 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HPG46_RS20900 ENOG4105S6R Iron-hydroxamate transporter permease subunit HPG46_RS20905 ENOG4108V5C ABC transporter HPG46_RS20915 ENOG4105C0A alcohol dehydrogenase HPG46_RS20920 ENOG4105C28 cystathionine HPG46_RS20950 ENOG4107XRG penicillin-binding protein HPG46_RS20965 ENOG4105CFP Peptidase U32 HPG46_RS20970 ENOG4105XYU peptidase (U32 family) HPG46_RS20980 ENOG4105HHA aminodeoxychorismate lyase HPG46_RS21010 ENOG4105C02 permease HPG46_RS21025 ENOG41060CR HPG46_RS21030 ENOG4105C7H Helicase, RecD TraA family HPG46_RS21045 ENOG4105C3J Cysteine desulfurase HPG46_RS21055 ENOG4105D1H recombination factor protein RarA HPG46_RS21060 ENOG4108VCI transcription factor, rsfa family HPG46_RS21065 ENOG4105CUZ uba thif-type nad fad binding protein HPG46_RS21095 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPG46_RS21105 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HPG46_RS21110 ENOG41076HS cation diffusion facilitator family transporter HPG46_RS21115 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPG46_RS21125 ENOG4105CKP Polysaccharide Biosynthesis Protein HPG46_RS21130 ENOG4108QG2 Membrane HPG46_RS21140 ENOG4105VIE preprotein translocase, subunit YajC HPG46_RS21155 ENOG41061AI Protein of unknown function (DUF2905) HPG46_RS21170 ENOG4108HUF Transporter HPG46_RS21180 ENOG4108IPJ Membrane HPG46_RS21185 ENOG41082BM Transcriptional regulator, arsr family HPG46_RS21210 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPG46_RS21215 ENOG4108IYU L-aspartate oxidase HPG46_RS21230 ENOG4108RPX mosc domain containing protein HPG46_RS21235 ENOG4105CQC Prephenate dehydratase HPG46_RS21255 ENOG4105EWM Histidine kinase HPG46_RS21280 ENOG4105X36 (ribosomal) protein HPG46_RS21290 ENOG4105C03 ribonuclease HPG46_RS21305 ENOG4107QMS site-determining protein HPG46_RS21325 ENOG4105DFF Rod shape-determining protein mreb HPG46_RS21345 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HPG46_RS21350 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HPG46_RS21360 ENOG41068KH stage VI sporulation protein D HPG46_RS21370 ENOG4105D52 delta-aminolevulinic acid dehydratase HPG46_RS21395 ENOG4105K56 Transcriptional regulator HPG46_RS21415 ENOG4108IUQ atp-dependent protease HPG46_RS21445 ENOG4108QCI YvbH-like oligomerisation region HPG46_RS21465 ENOG4105M59 Phosphodiesterase, mj0936 family HPG46_RS21480 ENOG4108XJQ germination protein HPG46_RS21490 ENOG4108PCX Major Facilitator HPG46_RS21500 ENOG4105KBX Transcriptional regulator, TetR family HPG46_RS21515 ENOG4105PFC Transcriptional regulator HPG46_RS21530 ENOG4105DZC cytosine deaminase HPG46_RS21535 ENOG4105DZC cytosine deaminase HPG46_RS21540 ENOG4105DEF Extracellular solute-binding protein, family 5 HPG46_RS21545 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPG46_RS21560 ENOG4108JQ7 (ABC) transporter HPG46_RS21565 ENOG4108HRK Histidine kinase HPG46_RS21570 ENOG4105DY9 regulatoR HPG46_RS21580 ENOG41067S9 phage shock protein C, PspC HPG46_RS21585 ENOG4108JCI Transcriptional regulator HPG46_RS21595 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HPG46_RS21600 ENOG4108Z40 Transcriptional regulator HPG46_RS21605 ENOG4105RHA ABC transporter, permease HPG46_RS21610 ENOG4108IUX (ABC) transporter HPG46_RS21615 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HPG46_RS21620 ENOG4105ER2 Ompa motb domain protein HPG46_RS21625 ENOG4105E14 MotA TolQ exbB proton channel HPG46_RS21630 ENOG4108VXD carboxy-peptidase HPG46_RS21640 ENOG4105E33 succinate dehydrogenase HPG46_RS21650 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HPG46_RS21665 ENOG4105K63 Thioredoxin HPG46_RS21670 ENOG4105C10 Electron transfer flavoprotein HPG46_RS21675 ENOG4105BZJ Electron transfer flavoprotein HPG46_RS21680 ENOG41060WC Enoyl-CoA hydratase HPG46_RS21685 ENOG4107Z3H Transcriptional regulator, TetR family HPG46_RS21690 ENOG4105CEY Amp-dependent synthetase and ligase HPG46_RS21700 ENOG4105J76 Periplasmic binding protein HPG46_RS21705 ENOG4105S6R Iron-hydroxamate transporter permease subunit HPG46_RS21740 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_RS21755 ENOG4105DR4 Methyltransferase HPG46_RS21770 ENOG4105KFN sortase, SrtB family HPG46_RS21775 ENOG4105E0A ABC, transporter HPG46_RS21790 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) HPG46_RS21795 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) HPG46_RS21805 ENOG4105FE9 pseudouridine synthase HPG46_RS21815 ENOG4105DCG PHP domain protein HPG46_RS21865 ENOG4108RWN rrna methyltransferase HPG46_RS21885 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPG46_RS21890 ENOG4105CW7 secretion protein, HlyD family HPG46_RS21895 ENOG4108JGH Tetr family transcriptional regulator HPG46_RS21900 ENOG4105CN9 Peptidase m42 family protein HPG46_RS21925 ENOG4105C22 threonyL-tRNA synthetase HPG46_RS21930 ENOG4108TDW sporulation protein YtxC HPG46_RS21955 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPG46_RS21960 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HPG46_RS21975 ENOG4105C2M dna polymerase I HPG46_RS21980 ENOG4105BZU Histidine kinase HPG46_RS21985 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_RS22005 ENOG4108HMX isocitrate dehydrogenase (NADP) HPG46_RS22010 ENOG4105BZN citrate synthase HPG46_RS22020 ENOG4108REF Sporulation integral membrane protein ytvi HPG46_RS22025 ENOG4105FS0 cytoplasmic membrane protein HPG46_RS22050 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HPG46_RS22055 ENOG4105C6K Malic enzyme HPG46_RS22060 ENOG4105C0B DNA polymerase III (alpha subunit) HPG46_RS22065 ENOG4105VV2 HPG46_RS22075 ENOG4105SFS phosphoesterase RecJ domain protein HPG46_RS22110 ENOG4105DC7 peptidase M24 HPG46_RS22150 ENOG4105Z7P Acetyltransferase (GNAT) family HPG46_RS22155 ENOG41082W1 Cupin 2, conserved barrel domain protein HPG46_RS22165 ENOG4105VZ8 Transcriptional regulator HPG46_RS22185 ENOG4107YZX Universal stress protein HPG46_RS22225 ENOG4108JYZ YitT family HPG46_RS22245 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPG46_RS22255 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HPG46_RS22260 ENOG4105KBJ sporulation protein ytfj HPG46_RS22275 ENOG4105EFZ amidohydrolase HPG46_RS22285 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPG46_RS22310 ENOG4106KR7 LysR family Transcriptional regulator HPG46_RS22320 ENOG4105U5Y Transcriptional regulator HPG46_RS22330 ENOG4105C28 cystathionine HPG46_RS22385 ENOG4105EMN RNA polymerase sigma factor HPG46_RS22400 ENOG4105F1V Acetoin utilization protein HPG46_RS22405 ENOG4105W87 Cbs domain HPG46_RS22410 ENOG4105DGU Histone deacetylase HPG46_RS22425 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_RS22430 ENOG4105BZU Histidine kinase HPG46_RS22435 ENOG4107SNB ankyrin repeat protein YahD HPG46_RS22440 ENOG4105EP9 oxidoreductase HPG46_RS22470 ENOG4105ETE Transcriptional regulator (LacI family HPG46_RS22490 ENOG4105C88 aminopeptidase HPG46_RS22515 ENOG4105K7K Transcriptional regulator HPG46_RS22545 ENOG4108VDD TRNA binding domain protein HPG46_RS22575 ENOG4105C8F Beta-lactamase domain protein HPG46_RS22590 ENOG4108V15 phosphotransferase enzyme family HPG46_RS22595 ENOG4108IUM Glycogen debranching enzyme HPG46_RS22605 ENOG4107QSE Dipeptidase HPG46_RS22610 ENOG4105YW5 deoR family transcriptional regulator HPG46_RS22625 ENOG4105CBX hi0933 family HPG46_RS22660 ENOG4108VJ1 Transcriptional regulator (CarD family HPG46_RS22665 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HPG46_RS22685 ENOG4108ZAF Molybdopterin HPG46_RS22690 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HPG46_RS22695 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPG46_RS22705 ENOG4105D06 uba thif-type nad fad binding protein HPG46_RS22710 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPG46_RS22730 ENOG41085GJ domain protein HPG46_RS22740 ENOG4105DWV Homoserine O-trans-acetylase HPG46_RS22750 ENOG4108B31 Spore germination protein HPG46_RS22780 ENOG410605W Major Facilitator HPG46_RS22785 ENOG4107S91 Sodium hydrogen exchanger HPG46_RS22790 ENOG4105NCW Trka-c domain protein HPG46_RS22805 ENOG4105C19 ABC transporter HPG46_RS22825 ENOG4105N5T Radical SAM Protein HPG46_RS22835 ENOG4105CIG ABC transporter HPG46_RS22880 ENOG4105E8V Alpha Beta Hydrolase Fold protein HPG46_RS22885 ENOG4108Z0R Transferase HPG46_RS22890 ENOG4105YVM Phosphoesterase, PA-phosphatase related HPG46_RS22895 ENOG4105BZF Glycosyl transferase (Group 1 HPG46_RS22905 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPG46_RS22960 ENOG4105EGD dinuclear metal center protein, YbgI family HPG46_RS22965 ENOG4105BZU Histidine kinase HPG46_RS22970 ENOG4105BZU Histidine kinase HPG46_RS22975 ENOG4107S9D Alpha beta hydrolase HPG46_RS22980 ENOG4107T7U Sulfatase HPG46_RS22995 ENOG4105D2X ABC transporter substrate-binding protein HPG46_RS23005 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HPG46_RS23020 ENOG4107XGZ Hydrolase HPG46_RS23060 ENOG4108V2W Carbonate dehydratase HPG46_RS23065 ENOG4105C4M (Ubiquinol oxidase) subunit I HPG46_RS23070 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPG46_RS23115 ENOG41087YS Phage shock protein A HPG46_RS23160 ENOG4105BZU Histidine kinase HPG46_RS23165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS23190 ENOG4108UGV hypoxanthine phosphoribosyltransferase HPG46_RS23195 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HPG46_RS23215 ENOG4105C19 ABC transporter HPG46_RS23230 ENOG4107ZTW SNARE associated Golgi HPG46_RS23240 ENOG41063TF transcriptional regulator (AraC HPG46_RS23255 ENOG4105C19 ABC transporter HPG46_RS23260 ENOG41086D8 Transcriptional regulator HPG46_RS23315 ENOG4105C6Z Gluconate HPG46_RS23340 ENOG41069H0 dihydroorotase EC 3.5.2.3 HPG46_RS23360 ENOG4105DTQ mandelate racemase muconate lactonizing HPG46_RS23370 ENOG4108IPT Naphthoate synthase HPG46_RS23375 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HPG46_RS23380 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HPG46_RS23385 ENOG4105E4F Isochorismate synthase HPG46_RS23390 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HPG46_RS23400 ENOG4105VEQ Cold shock protein HPG46_RS23445 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_RS23545 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HPG46_RS23580 ENOG4105KT7 mgtC SapB transporter HPG46_RS23585 ENOG4107PBV potassium channel HPG46_RS23600 ENOG4105WG9 Conserved Protein HPG46_RS23610 ENOG4105CHM Aminotransferase HPG46_RS23615 ENOG4108ZB6 transcriptional regulator AsnC family HPG46_RS23620 ENOG4105C5I Dehydrogenase HPG46_RS23625 ENOG4108MUZ hydrolase HPG46_RS23635 ENOG4105C87 Aminotransferase class I and II HPG46_RS23650 ENOG4105Y38 Kinase-associated protein B HPG46_RS23660 ENOG4107R3E Citrate transporter HPG46_RS23680 ENOG4105KA0 thioesterase Superfamily protein HPG46_RS23695 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPG46_RS23715 ENOG41069ER domain protein HPG46_RS23730 ENOG4105CEP NADH dehydrogenase HPG46_RS23760 ENOG4105EWC Purine nucleoside phosphorylase HPG46_RS23780 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HPG46_RS23805 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPG46_RS23810 ENOG4105C4B ABC transporter, permease HPG46_RS23815 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HPG46_RS23840 ENOG41083MR nifu domain-containing protein HPG46_RS23855 ENOG4108W5N phosphatidylglycerophosphatase a HPG46_RS23870 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPG46_RS23875 ENOG4105DYS nad(p)h dehydrogenase (quinone) HPG46_RS23885 ENOG4105D4U had-superfamily hydrolase, subfamily iia HPG46_RS23900 ENOG4105CBT Fructose-1,6-bisphosphatase HPG46_RS23915 ENOG4105MMD transcriptional regulator HPG46_RS23920 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HPG46_RS23925 ENOG4107TXC Transcriptional regulator HPG46_RS23930 ENOG41090T1 Membrane HPG46_RS23955 ENOG4105FAA peptidase M23 HPG46_RS23965 ENOG4105KZD Domain of unknown function (DUF1805) HPG46_RS23970 ENOG4107R8B 5'-nucleotidase HPG46_RS23985 ENOG4105DIW FeS assembly protein SUFB HPG46_RS23990 ENOG4108UNV SUF system FeS assembly protein, NifU family HPG46_RS23995 ENOG4105C9B Cysteine desulfurase HPG46_RS24000 ENOG4105JRK feS assembly protein SufD HPG46_RS24005 ENOG4105C3K feS assembly ATPase SufC HPG46_RS24010 ENOG4105D01 (LipO)protein HPG46_RS24015 ENOG4105D01 (LipO)protein HPG46_RS24020 ENOG4108UMI ABC transporter, permease HPG46_RS24050 ENOG41080E8 Transcriptional regulator, Spx MgsR family HPG46_RS24120 ENOG4108W8B Beta-lactamase domain protein HPG46_RS24125 ENOG4105C1G acyl-Coa dehydrogenase HPG46_RS24130 ENOG4105CHU acetyl-coa acetyltransferase HPG46_RS24145 ENOG4105DZ1 carboxypeptidase HPG46_RS24165 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPG46_RS24185 ENOG4108SUT Major Facilitator Superfamily HPG46_RS24190 ENOG4107R7I amino acid HPG46_RS24200 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HPG46_RS24210 ENOG4107AYK membrAne HPG46_RS24250 ENOG4107ZTW SNARE associated Golgi HPG46_RS24260 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPG46_RS24265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS24270 ENOG4105BZU Histidine kinase HPG46_RS24290 ENOG4105C8Q Methyl-accepting chemotaxis HPG46_RS24295 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPG46_RS24300 ENOG4105VG1 fes assembly suf system protein HPG46_RS24305 ENOG4105D4Y metalloprotease HPG46_RS24325 ENOG4107S91 Sodium hydrogen exchanger HPG46_RS24330 ENOG4105NCW Trka-c domain protein HPG46_RS24340 ENOG4108RMU ferritin dps family protein HPG46_RS24355 ENOG4108URH decarboxylase HPG46_RS24375 ENOG4105D9N nucleoside HPG46_RS24380 ENOG4105D9N nucleoside HPG46_RS24395 ENOG4108RYK Nad-dependent epimerase dehydratase HPG46_RS24415 ENOG4105CV8 reductase HPG46_RS24420 ENOG4105F27 Major Facilitator HPG46_RS24425 ENOG4105KVH Transcriptional regulator HPG46_RS24440 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HPG46_RS24445 ENOG4105D4A Cell wall formation (By similarity) HPG46_RS24455 ENOG4105C8Q Methyl-accepting chemotaxis HPG46_RS24485 ENOG4108MK9 spermidine N(1)-acetyltransferase HPG46_RS24505 ENOG4108IPW abc transporter atp-binding protein HPG46_RS24510 ENOG4105CM4 permease protein HPG46_RS24525 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS24545 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HPG46_RS24555 ENOG4105XZU Preprotein translocase, subunit SecG HPG46_RS24560 ENOG41067MG lrgb family HPG46_RS24610 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_RS24655 ENOG41090VF Stage v sporulation protein ac HPG46_RS24660 ENOG4105CZ3 stage V sporulation protein ad HPG46_RS24675 ENOG4105H67 Protein of unknown function (DUF421) HPG46_RS24685 ENOG4105KRI phosphocarrier protein (HPr HPG46_RS24695 ENOG4105CHW UPF0052 protein HPG46_RS24705 ENOG4108Z4K mutator MutT protein HPG46_RS24715 ENOG4105C3M thioredoxin reductase HPG46_RS24725 ENOG4108S4C acetyltransferase HPG46_RS24745 ENOG41086DT Membrane protein of unknown function HPG46_RS24755 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPG46_RS24775 ENOG4107TXC Transcriptional regulator HPG46_RS24805 ENOG4105HMI Membrane HPG46_RS24810 ENOG4105DUM transcriptional regulator, lysR family HPG46_RS24820 ENOG4108WS4 fmn reductase HPG46_RS24835 ENOG4105BZ1 (ABC) transporter HPG46_RS24840 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HPG46_RS24845 ENOG4107RSM transcriptional regulator HPG46_RS24855 ENOG4105CN1 protease HPG46_RS24860 ENOG4105CRP Part of the ABC transporter FtsEX involved in HPG46_RS24865 ENOG4105CAK Cell division ATP-binding protein ftsE HPG46_RS24885 ENOG4105MS2 ribosomal subunit Interface protein HPG46_RS24890 ENOG4105VEQ Cold shock protein HPG46_RS24895 ENOG41081UC Inherit from COG: Competence protein HPG46_RS24905 ENOG4105K4H Nlp p60 protein HPG46_RS24910 ENOG4105KVH Transcriptional regulator HPG46_RS24920 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HPG46_RS24925 ENOG4108KGH TRANSCRIPTIONal HPG46_RS24930 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPG46_RS24935 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPG46_RS24940 ENOG4105ESV Glycosyl transferase, family 4 HPG46_RS24950 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPG46_RS24970 ENOG4105F8D glycoside hydrolase family 4 HPG46_RS24975 ENOG4105VCP PTS System HPG46_RS24980 ENOG4105CK1 PTS System HPG46_RS24990 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HPG46_RS25000 ENOG4105VCP PTS System HPG46_RS25010 ENOG4105VZJ PTS System HPG46_RS25025 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HPG46_RS25030 ENOG4105ECB domain protein HPG46_RS25035 ENOG4107RSM transcriptional regulator HPG46_RS25090 ENOG4105DAA L-lactate HPG46_RS25100 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) HPG46_RS25110 ENOG4105E0M Sulfatase HPG46_RS25135 ENOG4107R8N Glycosyl transferase, family 2 HPG46_RS25140 ENOG4105C94 Transporter HPG46_RS25145 ENOG41069ER domain protein HPG46_RS25170 ENOG4105KBK Zinc finger, swim domain protein HPG46_RS25175 ENOG4105C0D helicase HPG46_RS25205 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPG46_RS25215 ENOG4107RBB ABC transporter, permease HPG46_RS25220 ENOG4105C19 ABC transporter HPG46_RS25240 ENOG4105CXY transporter HPG46_RS25255 ENOG4105BZU Histidine kinase HPG46_RS25260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS25265 ENOG4105CMR udp-glucose 4-epimerase HPG46_RS25290 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPG46_RS25295 ENOG4105EY8 ABC transporter HPG46_RS25345 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HPG46_RS25350 ENOG4107BJW polysaccharide deacetylase HPG46_RS25360 ENOG4105FRN stage II sporulation protein HPG46_RS25375 ENOG4105DY9 regulatoR HPG46_RS25395 ENOG4106778 Protein of unknown function (DUF1146) HPG46_RS25400 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPG46_RS25405 ENOG4105C8S subunit m HPG46_RS25410 ENOG4105D65 subunit l HPG46_RS25435 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPG46_RS25440 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HPG46_RS25455 ENOG4105BZU Histidine kinase HPG46_RS25505 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HPG46_RS25510 ENOG41062M3 atp synthase HPG46_RS25540 ENOG4108YZG isomerase HPG46_RS25555 ENOG4108VGI doxx family HPG46_RS25560 ENOG4107XC4 flavin reductase domain protein, FMN-binding HPG46_RS25575 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HPG46_RS25585 ENOG4108ZXQ stage ii sporulation protein r HPG46_RS25590 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPG46_RS25610 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HPG46_RS25615 ENOG4105CBT Fructose-1,6-bisphosphatase HPG46_RS25655 ENOG4105C1G acyl-Coa dehydrogenase HPG46_RS25660 ENOG4105C1G acyl-Coa dehydrogenase HPG46_RS25665 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPG46_RS25675 ENOG4105DF6 Fe-S oxidoreductase HPG46_RS25690 ENOG4105BZU Histidine kinase HPG46_RS25715 ENOG4105BZU Histidine kinase HPG46_RS25720 ENOG4105KCT ABC transporter HPG46_RS25725 ENOG4108M15 ABC transporter HPG46_RS25730 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HPG46_RS25740 ENOG4105IIU Aminopeptidase HPG46_RS25760 ENOG4105EMN RNA polymerase sigma factor HPG46_RS25770 ENOG410684U Domain of unknown function (DUF1934) HPG46_RS25790 ENOG4105CYW agmatinase HPG46_RS25800 ENOG4105DXB Major Facilitator superfamily HPG46_RS25805 ENOG4107SWG transcriptional regulator MERR family HPG46_RS25810 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HPG46_RS25815 ENOG4105BZ4 penicillin-binding protein HPG46_RS25820 ENOG4108XFG YwhD family HPG46_RS25825 ENOG4108Z4T Peptidase M50 HPG46_RS25830 ENOG41069HH 4-oxalocrotonate tautomerase HPG46_RS25835 ENOG4105DCI Phosphohydrolase HPG46_RS25840 ENOG4108MES Periplasmic binding protein HPG46_RS25845 ENOG4105E0A ABC, transporter HPG46_RS25850 ENOG4105EHG Permease protein HPG46_RS25855 ENOG4105DQ5 transport system permease protein HPG46_RS25865 ENOG4108VCI transcription factor, rsfa family HPG46_RS25880 ENOG4108IJ2 phosphate acetyltransferase HPG46_RS25895 ENOG4108VKI Cell wall hydrolase HPG46_RS25915 ENOG4107SVH Potassium channel protein HPG46_RS25925 ENOG410667J hydrolase HPG46_RS25930 ENOG4105VCH membrane HPG46_RS25940 ENOG4108TU7 Inherit from COG: (ABC) transporter HPG46_RS25945 ENOG4105CJ1 ABC, transporter HPG46_RS25950 ENOG41090WU lipolytic protein G-D-S-L family HPG46_RS25965 ENOG4105D6E homoserine dehydrogenase HPG46_RS25990 ENOG4108Y4K DNA-binding transcriptional activator HPG46_RS26000 ENOG4105WH1 Two component transcriptional regulator luxr family HPG46_RS26005 ENOG4105BZU Histidine kinase HPG46_RS26010 ENOG4105DWF phosphomethylpyrimidine kinase HPG46_RS26015 ENOG4105BZU Histidine kinase HPG46_RS26020 ENOG4105VCD cytoplasmic protein HPG46_RS26025 ENOG4105D22 carbon starvation protein HPG46_RS26030 ENOG4105DY9 regulatoR HPG46_RS26035 ENOG41079KZ Major Facilitator Superfamily HPG46_RS26055 ENOG4105EN6 Membrane HPG46_RS26060 ENOG4106YBV Methyl-accepting chemotaxis HPG46_RS26070 ENOG4108S4H thioesterase Superfamily protein HPG46_RS26080 ENOG4105JEU Glycosyl transferase, family 2 HPG46_RS26085 ENOG4105C5H ABC transporter HPG46_RS26105 ENOG4105CKK Glycosyl transferase, family 2 HPG46_RS26110 ENOG41067SE Tetr family transcriptional regulator HPG46_RS26120 ENOG4105E0X reductase HPG46_RS26125 ENOG4106F5Q Membrane HPG46_RS26140 ENOG4105DY9 regulatoR HPG46_RS26145 ENOG4108HRK Histidine kinase HPG46_RS26150 ENOG4107RGD Major Facilitator superfamily HPG46_RS26165 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPG46_RS26175 ENOG4105IW1 AmiS UreI transporter HPG46_RS26185 ENOG4105CMR udp-glucose 4-epimerase HPG46_RS26190 ENOG4108UT2 hemolysin iii HPG46_RS26200 ENOG4105C1J atp-dependent rna helicase HPG46_RS26215 ENOG4105DPN Oligoendopeptidase f HPG46_RS26235 ENOG4105C0H protease HPG46_RS26240 ENOG4105Q2H domain protein HPG46_RS26255 ENOG4105BZU Histidine kinase HPG46_RS26260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPG46_RS26290 ENOG4105CDU Replicative dna helicase HPG46_RS26300 ENOG4105BZR domain protein HPG46_RS26305 ENOG4108XMW Membrane HPG46_RS26315 ENOG4108UUM single-stranded DNA-binding protein HPG46_RS26325 ENOG4105C3G gtp-binding protein HPG46_RS26330 ENOG4105VDK protein, conserved in bacteria HPG46_RS26335 ENOG4105D8X mechanosensitive ion channel HPG46_RS26340 ENOG4108ZDA Sporulation protein YyaC HPG46_RS26345 ENOG4105FA0 parb-like partition protein HPG46_RS26350 ENOG4107QJE Chromosome Partitioning Protein HPG46_RS26380 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HPG46_RS26400 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPG46_RS26405 ENOG410848D S4 domain protein YaaA HPG46_RS26420 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPG46_RS26455 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HPG46_RS26490 ENOG4105ZMH deoxynucleoside kinase HPG46_RS26500 ENOG4105GTG Isochorismatase HPG46_RS26505 ENOG4108Z6B deaminase HPG46_RS26515 ENOG4105C6E dna polymerase iii HPG46_RS26535 ENOG41067KS pro-sigma K processing HPG46_RS26570 ENOG4105CXN decarboxylase HPG46_RS26580 ENOG4105FA2 dna polymerase iii HPG46_RS26585 ENOG4105MA4 psp1 domain protein HPG46_RS26595 ENOG41060K3 Methyltransferase HPG46_RS26605 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HPG46_RS26610 ENOG4105KRN Transcriptional regulator, abrb family HPG46_RS26620 ENOG4105F8V Hydrolase, tatD family HPG46_RS26625 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HPG46_RS26635 ENOG4105XFA sporulation peptidase YabG HPG46_RS26640 ENOG4105W42 Veg protein HPG46_RS26655 ENOG4105DFT pur operon repressor HPG46_RS26660 ENOG4105KME endoribonuclease L-psp HPG46_RS26690 ENOG4108JA2 transcriptioN-repair coupling factor HPG46_RS26695 ENOG4108M14 stage v sporulation protein t HPG46_RS26705 ENOG4108IY2 MazG family HPG46_RS26710 ENOG41082I2 s4 domain protein HPG46_RS26715 ENOG4105VYY sporulation protein yabp HPG46_RS26730 ENOG41060GV RNA binding s1 domain protein HPG46_RS26755 ENOG4108UGV hypoxanthine phosphoribosyltransferase HPG46_RS26760 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPG46_RS26775 ENOG4105C6T cysteine synthase HPG46_RS26780 ENOG4105CRQ synthase (Component I) HPG46_RS26785 ENOG4105DDQ anthranilate synthase HPG46_RS26790 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HPG46_RS26795 ENOG4105EEI dihydropteroate synthase HPG46_RS26800 ENOG4105KRF dihydroneopterin aldolase HPG46_RS26805 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HPG46_RS26815 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPG46_RS26845 ENOG4105D7V transposase HPG46_RS26855 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPG46_RS26900 ENOG4108IMY Transcriptional regulator HPG46_RS26905 ENOG4105BZC d-serine deaminase HPG46_RS26920 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPG46_RS26965 ENOG4105MZU cell filamentation protein HPG46_RS26975 ENOG4105EJQ L-serine dehydratase HPG46_RS26980 ENOG4105C44 Serine transporter HPG46_RS26995 ENOG4108JGH Tetr family transcriptional regulator HPG46_RS27000 ENOG4105EQ0 Major Facilitator superfamily HPG46_RS27005 ENOG4105MZU cell filamentation protein HPG46_RS27015 ENOG4107QJQ Mate efflux family protein HPG46_RS27030 ENOG4107QTZ amino acid HPG46_RS27060 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_RS27065 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_RS27080 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) HPG46_RS27090 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase HPG46_RS27095 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HPG46_RS27100 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HPG46_RS27105 ENOG4107RBJ symporter HPG46_RS27110 ENOG4108R6W Transcriptional regulator, ARAC family HPG46_RS27120 ENOG4105IIP Membrane HPG46_RS27125 ENOG4106AM8 polysaccharide lyase family 8 HPG46_RS27135 ENOG4105EP8 Glycosyl Hydrolase Family 88 HPG46_RS27140 ENOG4105DAS pts system HPG46_RS27145 ENOG4105F3R pts system mannose fructose sorbose family iid HPG46_RS27150 ENOG4105ETZ PTS System HPG46_RS27160 ENOG4105CHR reductase HPG46_RS27165 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) HPG46_RS27170 ENOG4105D7K pfkb domain protein HPG46_RS27180 ENOG4106P37 HTH-type transcriptional regulator YjhI HPG46_RS27235 ENOG4107XGZ Hydrolase HPG46_RS27240 ENOG41067FT ParB-like nuclease domain HPG46_RS27245 ENOG4107R8B 5'-nucleotidase HPG46_RS27270 ENOG4105CIH Imidazole acetol-phosphate transaminase HPG46_RS27295 ENOG4105E5W Transporter HPG46_RS27325 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPG46_RS27350 ENOG4105W8Z 4'-phosphopantetheinyl transferase HPG46_RS27385 ENOG4108MEK Metal-binding protein YodA HPG46_RS27400 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HPG46_RS27545 ENOG4107SET aldo keto reductase HPG46_RS27565 ENOG4105VTR Integrase HPG46_RS27750 ENOG4105K70 DNA-binding protein HPG46_RS27760 ENOG4105D7V transposase HPG46_RS27825 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_RS27830 ENOG4105WH1 Two component transcriptional regulator luxr family HPG46_RS27835 ENOG4108XG2 Histidine kinase HPG46_RS27905 ENOG4105E4C Lytic transglycosylase catalytic HPG46_RS27945 ENOG4105IIU Aminopeptidase HPG46_RS28035 ENOG4105T09 s-layer domain-containing protein HPG46_RS28045 ENOG4108M1A Chitin-binding protein HPG46_RS28065 ENOG4107SDU Methyl-accepting chemotaxis HPG46_RS28110 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HPG46_RS28155 ENOG4105D7V transposase HPG46_RS28200 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HPG46_RS28215 ENOG4105CNU cell division protein FtsK HPG46_RS28410 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HPG46_RS28520 ENOG4105DR5 peptidase HPG46_RS28525 ENOG4105D4Y metalloprotease HPG46_RS28545 ENOG4105F6J Alpha beta hydrolase fold HPG46_RS28550 ENOG4105DHF Membrane HPG46_RS28610 ENOG41067QW Transcriptional regulator HPG46_RS28620 ENOG4105D7V transposase HPG46_RS28635 ENOG41061CK Antibiotic biosynthesis monooxygenase HPG46_RS28680 ENOG4105W8Z 4'-phosphopantetheinyl transferase HPG46_RS28720 ENOG4105FQP Beta-lactamase HPG46_RS28730 ENOG4108IG5 Transcriptional regulator HPG46_RS28740 ENOG4105EMU Dehydrogenase HPG46_RS28765 ENOG410849A acetyltransferase, (GNAT) family HPG46_RS28790 ENOG41067QW Transcriptional regulator