locus-tag	class	description
HPG46_RS00085	COG3880	PFAM UvrB UvrC protein
HPG46_RS00095	COG0542	response to heat
HPG46_RS00100	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPG46_RS00110	COG4956	integral membrane protein (PIN domain superfamily)
HPG46_RS00130	COG1045	serine acetyltransferase
HPG46_RS00145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPG46_RS00150	COG3688	RNA-binding protein containing a PIN domain
HPG46_RS00165	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPG46_RS00170	COG0250	Participates in transcription elongation, termination and antitermination
HPG46_RS00175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPG46_RS00195	COG2813	Specifically methylates the guanine in position
HPG46_RS00210	COG1358	cellular component organization or biogenesis
HPG46_RS00280	COG0255	Belongs to the universal ribosomal protein uL29 family
HPG46_RS00340	COG0201	protein transport
HPG46_RS00350	COG0024	Methionine aminopeptidase
HPG46_RS00360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPG46_RS00395	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPG46_RS00420	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS00425	COG0489	protein tyrosine kinase activity
HPG46_RS00435	COG2194	sulfuric ester hydrolase activity
HPG46_RS00440	COG0726	polysaccharide deacetylase
HPG46_RS00520	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HPG46_RS00525	COG4856	YbbR-like protein
HPG46_RS00550	COG0596	Alpha beta hydrolase
HPG46_RS00570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPG46_RS00575	COG4946	Tricorn protease homolog
HPG46_RS00575	COG1506	peptidase
HPG46_RS00575	COG0823	Involved in the tonB-independent uptake of proteins
HPG46_RS00595	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS00600	COG2011	ABC-type metal ion transport system permease component
HPG46_RS00605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPG46_RS00610	COG1464	Belongs to the NlpA lipoprotein family
HPG46_RS00615	COG0604	alcohol dehydrogenase
HPG46_RS00625	COG0277	FAD linked oxidase domain protein
HPG46_RS00630	COG2271	Major facilitator Superfamily
HPG46_RS00640	COG2814	Major facilitator Superfamily
HPG46_RS00655	COG0601	transmembrane transport
HPG46_RS00660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_RS00665	COG0444	Belongs to the ABC transporter superfamily
HPG46_RS00670	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS00675	COG4166	transmembrane transport
HPG46_RS00685	COG2207	Transcriptional regulator
HPG46_RS00700	COG4166	transmembrane transport
HPG46_RS00705	COG4166	transmembrane transport
HPG46_RS00710	COG0656	L-ascorbic acid biosynthetic process
HPG46_RS00715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_RS00730	COG4149	molybdate abc transporter
HPG46_RS00735	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPG46_RS00740	COG1910	domain protein
HPG46_RS00755	COG0697	spore germination
HPG46_RS00770	COG0204	Acyl-transferase
HPG46_RS00780	COG1609	Transcriptional regulator
HPG46_RS00790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS00810	COG5298	Protein conserved in bacteria
HPG46_RS00835	COG0488	(ABC) transporter
HPG46_RS00850	COG0747	negative chemotaxis
HPG46_RS00855	COG0601	transmembrane transport
HPG46_RS00865	COG0444	Belongs to the ABC transporter superfamily
HPG46_RS00870	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS00875	COG0561	phosphatase activity
HPG46_RS00905	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HPG46_RS00910	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPG46_RS00920	COG0531	amino acid
HPG46_RS00925	COG2814	Major facilitator Superfamily
HPG46_RS00935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPG46_RS00945	COG4294	response to UV
HPG46_RS00950	COG0457	Tetratricopeptide repeat
HPG46_RS00950	COG0705	Rhomboid family
HPG46_RS00960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPG46_RS00965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPG46_RS00970	COG0864	Transcriptional regulator
HPG46_RS00975	COG2337	Toxic component of a toxin-antitoxin (TA) module
HPG46_RS00980	COG2183	response to ionizing radiation
HPG46_RS01075	COG0802	atpase or kinase
HPG46_RS01080	COG1214	PFAM Peptidase M22, glycoprotease
HPG46_RS01085	COG0456	acetyltransferase
HPG46_RS01095	COG0488	(ABC) transporter
HPG46_RS01110	COG1266	CAAX protease self-immunity
HPG46_RS01130	COG2252	PERMEase
HPG46_RS01140	COG5002	protein histidine kinase activity
HPG46_RS01165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HPG46_RS01195	COG2226	methyltransferase
HPG46_RS01215	COG1215	transferase activity, transferring glycosyl groups
HPG46_RS01255	COG2205	protein histidine kinase activity
HPG46_RS01260	COG0745	RESPONSE REGULATOR receiver
HPG46_RS01280	COG0697	spore germination
HPG46_RS01305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPG46_RS01310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPG46_RS01315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPG46_RS01325	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPG46_RS01340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPG46_RS01350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPG46_RS01360	COG0151	Belongs to the GarS family
HPG46_RS01385	COG0210	DNA helicase
HPG46_RS01395	COG4851	CamS sex pheromone cAM373 precursor
HPG46_RS01415	COG1335	isochorismatase
HPG46_RS01420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPG46_RS01425	COG2011	ABC-type metal ion transport system permease component
HPG46_RS01430	COG1464	Belongs to the NlpA lipoprotein family
HPG46_RS01445	COG0003	Pfam Anion-transporting ATPase
HPG46_RS01450	COG1846	Transcriptional regulator
HPG46_RS01455	COG4682	membrane
HPG46_RS01475	COG1597	lipid kinase activity
HPG46_RS01480	COG0546	phosphoglycolate phosphatase activity
HPG46_RS01485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPG46_RS01495	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS01500	COG2076	Multidrug Resistance protein
HPG46_RS01505	COG2309	aminopeptidase activity
HPG46_RS01520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS01525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPG46_RS01530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPG46_RS01535	COG5002	protein histidine kinase activity
HPG46_RS01540	COG4807	Protein conserved in bacteria
HPG46_RS01570	COG1473	amidohydrolase
HPG46_RS01585	COG0450	alkyl hydroperoxide reductase
HPG46_RS01605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS01610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS01615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS01630	COG0166	Belongs to the GPI family
HPG46_RS01685	COG3541	Predicted nucleotidyltransferase
HPG46_RS01690	COG2814	Major facilitator Superfamily
HPG46_RS01695	COG0723	plastoquinol--plastocyanin reductase activity
HPG46_RS01695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_RS01705	COG0765	amino acid transport
HPG46_RS01710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_RS01720	COG0840	transmembrane signaling receptor activity
HPG46_RS01725	COG0840	transmembrane signaling receptor activity
HPG46_RS01730	COG0366	Alpha amylase catalytic
HPG46_RS01735	COG1263	PTS System
HPG46_RS01735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS01735	COG2190	(PTS) system
HPG46_RS01765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPG46_RS01780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_RS01790	COG1116	anion transmembrane transporter activity
HPG46_RS01800	COG0488	(ABC) transporter
HPG46_RS01850	COG2270	Major facilitator Superfamily
HPG46_RS01880	COG2310	stress, protein
HPG46_RS01885	COG2310	stress, protein
HPG46_RS01890	COG2310	stress, protein
HPG46_RS01895	COG0861	Integral membrane protein TerC family
HPG46_RS01905	COG3853	Toxic anion resistance protein (TelA)
HPG46_RS01920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPG46_RS01930	COG1295	ribonuclease BN
HPG46_RS01935	COG2217	Heavy metal translocating P-type atpase
HPG46_RS01940	COG0697	spore germination
HPG46_RS01950	COG0681	Belongs to the peptidase S26 family
HPG46_RS01960	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS01975	COG3871	stress protein (general stress protein 26)
HPG46_RS01980	COG0387	Pfam Sodium calcium exchanger
HPG46_RS01990	COG0535	radical SAM domain protein
HPG46_RS02010	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPG46_RS02015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPG46_RS02030	COG3829	transcription factor binding
HPG46_RS02040	COG0833	amino acid
HPG46_RS02045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPG46_RS02075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS02075	COG1263	PTS System
HPG46_RS02080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_RS02100	COG0463	Glycosyl transferase, family 2
HPG46_RS02110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPG46_RS02110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPG46_RS02130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPG46_RS02150	COG1228	amidohydrolase
HPG46_RS02155	COG1090	epimerase
HPG46_RS02185	COG1988	membrane-bound metal-dependent
HPG46_RS02190	COG1194	a g-specific adenine glycosylase
HPG46_RS02215	COG1132	(ABC) transporter
HPG46_RS02220	COG4129	membrane
HPG46_RS02225	COG0067	glutamate synthase
HPG46_RS02225	COG0070	glutamate synthase
HPG46_RS02225	COG0069	glutamate synthase activity
HPG46_RS02235	COG4555	ABC transporter
HPG46_RS02255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPG46_RS02260	COG0735	belongs to the Fur family
HPG46_RS02375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPG46_RS02380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPG46_RS02390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPG46_RS02400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPG46_RS02410	COG2766	serine protein kinase
HPG46_RS02430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPG46_RS02440	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPG46_RS02445	COG2268	Band 7 protein
HPG46_RS02455	COG3290	protein histidine kinase activity
HPG46_RS02460	COG4565	transcriptional regulatory protein
HPG46_RS02465	COG2851	Citrate transporter
HPG46_RS02485	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HPG46_RS02490	COG3842	ATPase activity
HPG46_RS02495	COG1175	transmembrane transport
HPG46_RS02500	COG0395	ABC-type sugar transport system, permease component
HPG46_RS02510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPG46_RS02515	COG0745	RESPONSE REGULATOR receiver
HPG46_RS02520	COG5002	protein histidine kinase activity
HPG46_RS02530	COG4990	cell redox homeostasis
HPG46_RS02540	COG3290	protein histidine kinase activity
HPG46_RS02545	COG4565	transcriptional regulatory protein
HPG46_RS02550	COG3493	citrate carrier protein
HPG46_RS02555	COG0281	malic enzyme
HPG46_RS02570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS02580	COG5002	protein histidine kinase activity
HPG46_RS02585	COG0745	RESPONSE REGULATOR receiver
HPG46_RS02590	COG0454	-acetyltransferase
HPG46_RS02590	COG0456	acetyltransferase
HPG46_RS02595	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPG46_RS02600	COG3383	formate dehydrogenase (NAD+) activity
HPG46_RS02605	COG2427	Protein of unknown function (DUF1641)
HPG46_RS02620	COG0531	amino acid
HPG46_RS02625	COG0640	Transcriptional regulator
HPG46_RS02630	COG2217	Heavy metal translocating P-type atpase
HPG46_RS02635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPG46_RS02650	COG3227	Zinc metalloprotease (Elastase)
HPG46_RS02670	COG2720	vancomycin resistance protein
HPG46_RS02675	COG1316	TRANSCRIPTIONal
HPG46_RS02680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS02685	COG0346	lactoylglutathione lyase activity
HPG46_RS02690	COG1253	flavin adenine dinucleotide binding
HPG46_RS02695	COG1027	Aspartate ammonia-lyase
HPG46_RS02700	COG1620	l-lactate permease
HPG46_RS02715	COG3104	oligopeptide transport
HPG46_RS02720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS02725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS02730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS02740	COG2226	methyltransferase
HPG46_RS02745	COG0156	8-amino-7-oxononanoate synthase activity
HPG46_RS02750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPG46_RS02755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPG46_RS02765	COG4548	von Willebrand factor, type A
HPG46_RS02770	COG0714	Associated with various cellular activities
HPG46_RS02775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_RS02795	COG0531	amino acid
HPG46_RS02800	COG2188	Transcriptional regulator
HPG46_RS02805	COG1263	PTS System
HPG46_RS02805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS02810	COG0366	Alpha amylase catalytic
HPG46_RS02825	COG0697	spore germination
HPG46_RS02835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPG46_RS02840	COG1115	amino acid carrier protein
HPG46_RS02845	COG1126	abc transporter atp-binding protein
HPG46_RS02850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_RS02855	COG0765	amino acid transport
HPG46_RS02860	COG0765	amino acid transport
HPG46_RS02865	COG0833	amino acid
HPG46_RS02890	COG2378	regulation of single-species biofilm formation
HPG46_RS02895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPG46_RS02900	COG5002	protein histidine kinase activity
HPG46_RS02915	COG0659	secondary active sulfate transmembrane transporter activity
HPG46_RS02930	COG0747	negative chemotaxis
HPG46_RS02940	COG0601	transmembrane transport
HPG46_RS02945	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS02955	COG2271	Major facilitator Superfamily
HPG46_RS02960	COG1846	Transcriptional regulator
HPG46_RS02965	COG0477	Major facilitator Superfamily
HPG46_RS02970	COG1609	Transcriptional regulator
HPG46_RS02975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPG46_RS02990	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPG46_RS02995	COG1879	ABC-type sugar transport system periplasmic component
HPG46_RS03015	COG1063	alcohol dehydrogenase
HPG46_RS03030	COG3568	Endonuclease Exonuclease Phosphatase
HPG46_RS03060	COG0840	transmembrane signaling receptor activity
HPG46_RS03065	COG1388	LysM domain
HPG46_RS03065	COG3584	3D domain protein
HPG46_RS03070	COG1476	TRANSCRIPTIONal
HPG46_RS03085	COG3104	oligopeptide transport
HPG46_RS03090	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS03095	COG1464	Belongs to the NlpA lipoprotein family
HPG46_RS03100	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS03105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPG46_RS03110	COG2011	ABC-type metal ion transport system permease component
HPG46_RS03125	COG1113	amino acid transport
HPG46_RS03130	COG2252	PERMEase
HPG46_RS03145	COG2153	protein acetylation
HPG46_RS03155	COG0475	glutathione-regulated potassium exporter activity
HPG46_RS03155	COG0569	domain protein
HPG46_RS03170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPG46_RS03175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPG46_RS03180	COG0833	amino acid
HPG46_RS03185	COG4990	cell redox homeostasis
HPG46_RS03200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_RS03205	COG0697	spore germination
HPG46_RS03210	COG0531	amino acid
HPG46_RS03220	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPG46_RS03225	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPG46_RS03230	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPG46_RS03230	COG1918	ferrous iron import across plasma membrane
HPG46_RS03235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPG46_RS03240	COG0573	inorganic phosphate transmembrane transporter activity
HPG46_RS03245	COG0581	inorganic phosphate transmembrane transporter activity
HPG46_RS03255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPG46_RS03375	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HPG46_RS03395	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPG46_RS03400	COG1116	anion transmembrane transporter activity
HPG46_RS03405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_RS03410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPG46_RS03415	COG0352	thiamine-phosphate diphosphorylase activity
HPG46_RS03420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_RS03425	COG2104	thiamine diphosphate biosynthetic process
HPG46_RS03435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_RS03440	COG0351	phosphomethylpyrimidine kinase
HPG46_RS03480	COG2205	protein histidine kinase activity
HPG46_RS03485	COG2814	Major facilitator Superfamily
HPG46_RS03490	COG1846	Transcriptional regulator
HPG46_RS03515	COG1136	(ABC) transporter
HPG46_RS03515	COG0577	efflux transmembrane transporter activity
HPG46_RS03525	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPG46_RS03535	COG1879	ABC-type sugar transport system periplasmic component
HPG46_RS03540	COG2252	PERMEase
HPG46_RS03545	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS03550	COG1376	ErfK ybiS ycfS ynhG family protein
HPG46_RS03565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_RS03605	COG0778	Nitroreductase
HPG46_RS03610	COG2719	SpoVR family
HPG46_RS03615	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPG46_RS03620	COG1937	Protein conserved in bacteria
HPG46_RS03625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS03625	COG0425	Belongs to the sulfur carrier protein TusA family
HPG46_RS03630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS03630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS03635	COG0425	Belongs to the sulfur carrier protein TusA family
HPG46_RS03640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS03650	COG2210	Belongs to the sulfur carrier protein TusA family
HPG46_RS03655	COG0730	response to heat
HPG46_RS03665	COG1316	TRANSCRIPTIONal
HPG46_RS03670	COG0604	alcohol dehydrogenase
HPG46_RS03675	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPG46_RS03690	COG3711	transcriptional antiterminator
HPG46_RS03690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_RS03695	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_RS03700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_RS03720	COG3584	3D domain protein
HPG46_RS03720	COG1388	LysM domain
HPG46_RS03725	COG0577	efflux transmembrane transporter activity
HPG46_RS03730	COG1136	(ABC) transporter
HPG46_RS03740	COG5522	Integral membrane protein (intg_mem_TP0381)
HPG46_RS03755	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS03760	COG3546	catalase activity
HPG46_RS03795	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS03830	COG0531	amino acid
HPG46_RS03835	COG0475	glutathione-regulated potassium exporter activity
HPG46_RS03845	COG1737	Transcriptional regulator
HPG46_RS03855	COG1263	PTS System
HPG46_RS03855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS03865	COG2259	Doxx family
HPG46_RS03880	COG0697	spore germination
HPG46_RS03885	COG1522	sequence-specific DNA binding
HPG46_RS03900	COG2076	Multidrug Resistance protein
HPG46_RS03905	COG1309	transcriptional regulator
HPG46_RS03910	COG2814	Major facilitator Superfamily
HPG46_RS03920	COG1309	transcriptional regulator
HPG46_RS03925	COG2124	cytochrome p450
HPG46_RS03935	COG1063	alcohol dehydrogenase
HPG46_RS03940	COG4533	DNA binding
HPG46_RS03945	COG2211	Major facilitator Superfamily
HPG46_RS03955	COG0693	protein deglycase activity
HPG46_RS03960	COG0693	protein deglycase activity
HPG46_RS03960	COG0753	catalase activity
HPG46_RS03970	COG0531	amino acid
HPG46_RS03985	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS03990	COG1132	(ABC) transporter
HPG46_RS03995	COG1132	(ABC) transporter
HPG46_RS04000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_RS04005	COG0765	amino acid transport
HPG46_RS04010	COG1126	abc transporter atp-binding protein
HPG46_RS04025	COG0189	ligase activity
HPG46_RS04055	COG0028	Belongs to the TPP enzyme family
HPG46_RS04060	COG3527	Alpha-acetolactate decarboxylase
HPG46_RS04070	COG0561	phosphatase activity
HPG46_RS04075	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS04075	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_RS04080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPG46_RS04085	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS04095	COG0659	secondary active sulfate transmembrane transporter activity
HPG46_RS04120	COG0653	protein targeting
HPG46_RS04125	COG2244	polysaccharide biosynthetic process
HPG46_RS04135	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS04140	COG4196	transglutaminase domain protein
HPG46_RS04155	COG1696	Membrane protein involved in D-alanine export
HPG46_RS04170	COG1024	Enoyl-CoA hydratase
HPG46_RS04195	COG1363	Peptidase, m42
HPG46_RS04215	COG3938	Belongs to the proline racemase family
HPG46_RS04255	COG0601	transmembrane transport
HPG46_RS04260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_RS04265	COG0444	Belongs to the ABC transporter superfamily
HPG46_RS04270	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS04285	COG0477	Major facilitator Superfamily
HPG46_RS04290	COG3290	protein histidine kinase activity
HPG46_RS04295	COG4565	transcriptional regulatory protein
HPG46_RS04300	COG3181	Tripartite tricarboxylate transporter family receptor
HPG46_RS04345	COG0789	Transcriptional regulator
HPG46_RS04345	COG4978	Transcriptional regulator
HPG46_RS04360	COG0305	Participates in initiation and elongation during chromosome replication
HPG46_RS04400	COG0477	Major facilitator Superfamily
HPG46_RS04445	COG3320	Male sterility
HPG46_RS04445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPG46_RS04450	COG1309	transcriptional regulator
HPG46_RS04465	COG1183	phosphatidylcholine synthase activity
HPG46_RS04485	COG2376	Dihydroxyacetone kinase
HPG46_RS04495	COG2376	Dihydroxyacetone kinase
HPG46_RS04505	COG1959	2 iron, 2 sulfur cluster binding
HPG46_RS04595	COG1136	(ABC) transporter
HPG46_RS04600	COG0577	efflux transmembrane transporter activity
HPG46_RS04655	COG1191	sigma factor activity
HPG46_RS04665	COG2208	phosphoserine phosphatase activity
HPG46_RS04670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPG46_RS04675	COG2198	Histidine kinase
HPG46_RS04675	COG0784	Response regulator, receiver
HPG46_RS04675	COG2205	protein histidine kinase activity
HPG46_RS04675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_RS04730	COG0420	3'-5' exonuclease activity
HPG46_RS04735	COG4717	serine-type aminopeptidase activity
HPG46_RS04770	COG0346	lactoylglutathione lyase activity
HPG46_RS04775	COG0346	lactoylglutathione lyase activity
HPG46_RS04780	COG0457	Tetratricopeptide repeat
HPG46_RS04790	COG2267	carboxylic ester hydrolase activity
HPG46_RS04810	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HPG46_RS04815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPG46_RS04825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPG46_RS04870	COG0477	Major facilitator Superfamily
HPG46_RS04875	COG0477	Major facilitator Superfamily
HPG46_RS04885	COG3973	AAA domain
HPG46_RS04890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPG46_RS04910	COG4980	gas vesicle protein
HPG46_RS04915	COG0537	adenosine 5'-monophosphoramidase activity
HPG46_RS04920	COG1131	(ABC) transporter
HPG46_RS04925	COG4473	ABC transporter
HPG46_RS04980	COG1309	transcriptional regulator
HPG46_RS04990	COG3402	PFAM membrane-flanked domain
HPG46_RS04995	COG3428	Bacterial PH domain
HPG46_RS05035	COG3402	PFAM membrane-flanked domain
HPG46_RS05040	COG3428	Bacterial PH domain
HPG46_RS05045	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_RS05050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_RS05100	COG1309	transcriptional regulator
HPG46_RS05105	COG1511	domain protein
HPG46_RS05130	COG2378	regulation of single-species biofilm formation
HPG46_RS05135	COG1609	Transcriptional regulator
HPG46_RS05145	COG1234	tRNA 3'-trailer cleavage
HPG46_RS05150	COG0095	Lipoate-protein ligase
HPG46_RS05160	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS05180	COG1408	metallophosphoesterase
HPG46_RS05190	COG1078	dGTPase activity
HPG46_RS05200	COG1595	DNA-templated transcription, initiation
HPG46_RS05205	COG2207	Transcriptional regulator
HPG46_RS05205	COG3708	Transcriptional regulator
HPG46_RS05220	COG2205	protein histidine kinase activity
HPG46_RS05225	COG0745	RESPONSE REGULATOR receiver
HPG46_RS05250	COG0501	Belongs to the peptidase M48B family
HPG46_RS05255	COG0840	transmembrane signaling receptor activity
HPG46_RS05260	COG0697	spore germination
HPG46_RS05280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPG46_RS05285	COG2224	Isocitrate lyase
HPG46_RS05310	COG4903	ComK protein
HPG46_RS05315	COG0398	Pfam SNARE associated Golgi protein
HPG46_RS05375	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPG46_RS05400	COG0367	asparagine synthase
HPG46_RS05410	COG0753	catalase activity
HPG46_RS05415	COG0004	ammonium transporteR
HPG46_RS05435	COG2996	Protein conserved in bacteria
HPG46_RS05445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPG46_RS05455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS05470	COG0561	phosphatase activity
HPG46_RS05480	COG0542	response to heat
HPG46_RS05490	COG2267	carboxylic ester hydrolase activity
HPG46_RS05505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS05510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPG46_RS05515	COG5504	Zn-dependent protease
HPG46_RS05525	COG0180	Tryptophanyl-tRNA synthetase
HPG46_RS05535	COG4166	transmembrane transport
HPG46_RS05540	COG0601	transmembrane transport
HPG46_RS05545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_RS05550	COG0444	Belongs to the ABC transporter superfamily
HPG46_RS05555	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS05560	COG0534	Mate efflux family protein
HPG46_RS05565	COG4166	transmembrane transport
HPG46_RS05580	COG0861	Integral membrane protein TerC family
HPG46_RS05585	COG4862	establishment of competence for transformation
HPG46_RS05590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_RS05600	COG1164	Oligoendopeptidase f
HPG46_RS05615	COG2346	COG2346, Truncated hemoglobins
HPG46_RS05620	COG4116	CYTH
HPG46_RS05630	COG2357	RelA SpoT domain protein
HPG46_RS05640	COG0564	pseudouridine synthase activity
HPG46_RS05655	COG0772	Belongs to the SEDS family
HPG46_RS05660	COG0463	Glycosyl transferase, family 2
HPG46_RS05660	COG1216	Glycosyl transferase, family 2
HPG46_RS05680	COG0463	Glycosyl transferase, family 2
HPG46_RS05680	COG0457	Tetratricopeptide repeat
HPG46_RS05700	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPG46_RS05715	COG1091	dTDP-4-dehydrorhamnose reductase activity
HPG46_RS05760	COG2153	protein acetylation
HPG46_RS05770	COG2382	esterase
HPG46_RS05785	COG5492	domain, Protein
HPG46_RS05790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_RS05800	COG0512	Glutamine amidotransferase of anthranilate synthase
HPG46_RS05800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPG46_RS05835	COG1620	l-lactate permease
HPG46_RS05840	COG5634	Uncharacterized conserved protein (DUF2278)
HPG46_RS05895	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPG46_RS05905	COG1476	TRANSCRIPTIONal
HPG46_RS05960	COG2226	methyltransferase
HPG46_RS05970	COG1686	Belongs to the peptidase S11 family
HPG46_RS05975	COG0681	Belongs to the peptidase S26 family
HPG46_RS06010	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS06020	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPG46_RS06025	COG1177	transmembrane transport
HPG46_RS06030	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPG46_RS06040	COG2409	Drug exporters of the RND superfamily
HPG46_RS06050	COG0564	pseudouridine synthase activity
HPG46_RS06060	COG2340	Cysteine-rich secretory protein family
HPG46_RS06065	COG0247	lactate metabolic process
HPG46_RS06070	COG0277	FAD linked oxidase domain protein
HPG46_RS06075	COG3835	regulator
HPG46_RS06085	COG0745	RESPONSE REGULATOR receiver
HPG46_RS06090	COG5002	protein histidine kinase activity
HPG46_RS06095	COG2186	Transcriptional regulator
HPG46_RS06115	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HPG46_RS06125	COG2116	formate transmembrane transporter activity
HPG46_RS06130	COG0861	Integral membrane protein TerC family
HPG46_RS06135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPG46_RS06145	COG2030	dehydratase
HPG46_RS06165	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS06170	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPG46_RS06180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPG46_RS06195	COG1840	ABC-type Fe3 transport system, periplasmic component
HPG46_RS06200	COG3842	ATPase activity
HPG46_RS06225	COG1349	DNA-binding transcription factor activity
HPG46_RS06235	COG0235	Class ii aldolase
HPG46_RS06245	COG2861	carbohydrate metabolic process
HPG46_RS06255	COG3852	Histidine kinase
HPG46_RS06260	COG1846	Transcriptional regulator
HPG46_RS06270	COG2318	DinB family
HPG46_RS06275	COG5002	protein histidine kinase activity
HPG46_RS06285	COG0720	synthase
HPG46_RS06300	COG4873	Protein conserved in bacteria
HPG46_RS06330	COG1780	Probably involved in ribonucleotide reductase function
HPG46_RS06350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPG46_RS06355	COG1725	Transcriptional regulator
HPG46_RS06360	COG1131	(ABC) transporter
HPG46_RS06370	COG1131	(ABC) transporter
HPG46_RS06375	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPG46_RS06390	COG1522	sequence-specific DNA binding
HPG46_RS06410	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_RS06415	COG2070	2-Nitropropane dioxygenase
HPG46_RS06420	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HPG46_RS06430	COG1696	Membrane protein involved in D-alanine export
HPG46_RS06455	COG0716	FMN binding
HPG46_RS06470	COG3173	Aminoglycoside phosphotransferase
HPG46_RS06495	COG1968	undecaprenyl-diphosphatase activity
HPG46_RS06510	COG1846	Transcriptional regulator
HPG46_RS06520	COG1301	dicarboxylic acid transport
HPG46_RS06525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPG46_RS06530	COG4709	membrane
HPG46_RS06535	COG3874	Sporulation protein YtfJ
HPG46_RS06555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_RS06560	COG0028	Belongs to the TPP enzyme family
HPG46_RS06565	COG0440	acetolactate synthase activity
HPG46_RS06640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPG46_RS06655	COG1183	phosphatidylcholine synthase activity
HPG46_RS06660	COG1368	sulfuric ester hydrolase activity
HPG46_RS06670	COG0019	diaminopimelate decarboxylase activity
HPG46_RS06690	COG0529	Catalyzes the synthesis of activated sulfate
HPG46_RS06695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPG46_RS06715	COG1648	precorrin-2 dehydrogenase activity
HPG46_RS06720	COG0733	neurotransmitter:sodium symporter activity
HPG46_RS06740	COG1757	Na H antiporter
HPG46_RS06755	COG4758	membrane
HPG46_RS06760	COG4585	Histidine kinase
HPG46_RS06765	COG2197	response regulator
HPG46_RS06775	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS06785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPG46_RS06825	COG0730	response to heat
HPG46_RS06830	COG0306	phosphate transporter
HPG46_RS06835	COG1392	Phosphate transport regulator
HPG46_RS06840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_RS06855	COG3852	Histidine kinase
HPG46_RS06860	COG1801	Protein of unknown function DUF72
HPG46_RS06870	COG0582	viral genome integration into host DNA
HPG46_RS06875	COG5002	protein histidine kinase activity
HPG46_RS06890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HPG46_RS06890	COG0392	lysyltransferase activity
HPG46_RS06905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPG46_RS06910	COG1686	Belongs to the peptidase S11 family
HPG46_RS06915	COG2715	membrane protein required for spore maturation
HPG46_RS06920	COG0700	Nucleoside recognition
HPG46_RS06925	COG1187	pseudouridine synthase activity
HPG46_RS06935	COG1333	cytochrome c biogenesis protein
HPG46_RS06940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPG46_RS06945	COG0745	RESPONSE REGULATOR receiver
HPG46_RS06950	COG5002	protein histidine kinase activity
HPG46_RS06955	COG2096	Adenosyltransferase
HPG46_RS06960	COG4942	peptidase
HPG46_RS06970	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HPG46_RS06975	COG1141	Ferredoxin
HPG46_RS06985	COG0514	ATP-dependent DNA helicase (RecQ)
HPG46_RS06990	COG1266	CAAX protease self-immunity
HPG46_RS07000	COG1408	metallophosphoesterase
HPG46_RS07010	COG4862	establishment of competence for transformation
HPG46_RS07015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPG46_RS07035	COG0492	ferredoxin-NADP+ reductase activity
HPG46_RS07110	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPG46_RS07125	COG0142	geranyltranstransferase activity
HPG46_RS07135	COG0142	geranyltranstransferase activity
HPG46_RS07155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPG46_RS07160	COG0457	Tetratricopeptide repeat
HPG46_RS07180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPG46_RS07190	COG4347	Protein of unknown function (DUF1405)
HPG46_RS07205	COG2738	Putative neutral zinc metallopeptidase
HPG46_RS07215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS07220	COG1694	Mazg nucleotide pyrophosphohydrolase
HPG46_RS07235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPG46_RS07240	COG0438	transferase activity, transferring glycosyl groups
HPG46_RS07275	COG1199	ATP-dependent helicase activity
HPG46_RS07275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPG46_RS07295	COG3935	DnaD domain protein
HPG46_RS07300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPG46_RS07310	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPG46_RS07310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_RS07370	COG0116	Belongs to the methyltransferase superfamily
HPG46_RS07380	COG1199	ATP-dependent helicase activity
HPG46_RS07385	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPG46_RS07395	COG3173	Aminoglycoside phosphotransferase
HPG46_RS07400	COG0024	Methionine aminopeptidase
HPG46_RS07410	COG2233	PERMEase
HPG46_RS07415	COG2311	Membrane
HPG46_RS07420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPG46_RS07430	COG0456	acetyltransferase
HPG46_RS07465	COG0754	glutathionylspermidine amidase activity
HPG46_RS07480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPG46_RS07505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPG46_RS07520	COG1215	transferase activity, transferring glycosyl groups
HPG46_RS07525	COG0438	transferase activity, transferring glycosyl groups
HPG46_RS07540	COG0454	-acetyltransferase
HPG46_RS07560	COG0328	RNA-DNA hybrid ribonuclease activity
HPG46_RS07595	COG3403	YqcI/YcgG family
HPG46_RS07600	COG1280	lysine exporter protein (LysE YggA)
HPG46_RS07615	COG3162	membrane
HPG46_RS07620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_RS07625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPG46_RS07635	COG0475	glutathione-regulated potassium exporter activity
HPG46_RS07640	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPG46_RS07645	COG0789	Transcriptional regulator
HPG46_RS07645	COG4978	Transcriptional regulator
HPG46_RS07655	COG2323	membrane
HPG46_RS07660	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPG46_RS07715	COG1923	regulation of RNA biosynthetic process
HPG46_RS07725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPG46_RS07730	COG1360	Flagellar Motor Protein
HPG46_RS07735	COG2201	protein-glutamate methylesterase activity
HPG46_RS07740	COG2198	Histidine kinase
HPG46_RS07740	COG0643	Histidine kinase
HPG46_RS07745	COG1776	CheC inhibitor of MCP methylation
HPG46_RS07745	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_RS07760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPG46_RS07780	COG1256	bacterial-type flagellum assembly
HPG46_RS07785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPG46_RS07790	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPG46_RS07805	COG1815	bacterial-type flagellum-dependent cell motility
HPG46_RS07810	COG1558	bacterial-type flagellum-dependent cell motility
HPG46_RS07820	COG1766	The M ring may be actively involved in energy transduction
HPG46_RS07825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_RS07835	COG1157	protein secretion by the type III secretion system
HPG46_RS07870	COG0835	chemotaxis
HPG46_RS07870	COG0784	Response regulator, receiver
HPG46_RS07910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPG46_RS07915	COG0741	lytic transglycosylase activity
HPG46_RS07925	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_RS07930	COG1776	CheC inhibitor of MCP methylation
HPG46_RS07930	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_RS07940	COG1338	Plays a role in the flagellum-specific transport system
HPG46_RS07945	COG1987	bacterial-type flagellum assembly
HPG46_RS07955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPG46_RS07960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPG46_RS07965	COG1419	protein localization to endoplasmic reticulum
HPG46_RS07970	COG4786	Flagellar basal body rod
HPG46_RS07975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPG46_RS08020	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_RS08045	COG0583	DNA-binding transcription factor activity
HPG46_RS08050	COG3842	ATPase activity
HPG46_RS08055	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPG46_RS08065	COG1234	tRNA 3'-trailer cleavage
HPG46_RS08120	COG0406	alpha-ribazole phosphatase activity
HPG46_RS08150	COG0367	asparagine synthase
HPG46_RS08180	COG1802	Transcriptional regulator
HPG46_RS08185	COG0697	spore germination
HPG46_RS08190	COG0523	cobalamin synthesis protein
HPG46_RS08195	COG0701	Predicted permease
HPG46_RS08205	COG1216	Glycosyl transferase, family 2
HPG46_RS08205	COG0438	transferase activity, transferring glycosyl groups
HPG46_RS08210	COG1757	Na H antiporter
HPG46_RS08215	COG0114	fumarate hydratase activity
HPG46_RS08230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS08240	COG0534	Mate efflux family protein
HPG46_RS08245	COG3340	Belongs to the peptidase S51 family
HPG46_RS08265	COG0785	Cytochrome C biogenesis protein
HPG46_RS08295	COG2733	membrane
HPG46_RS08330	COG1131	(ABC) transporter
HPG46_RS08345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_RS08350	COG0528	UMP kinase activity
HPG46_RS08360	COG1027	Aspartate ammonia-lyase
HPG46_RS08365	COG0281	malic enzyme
HPG46_RS08370	COG4191	Histidine kinase
HPG46_RS08375	COG0784	Response regulator, receiver
HPG46_RS08380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPG46_RS08400	COG3620	sequence-specific DNA binding
HPG46_RS08425	COG1051	belongs to the nudix hydrolase family
HPG46_RS08430	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS08440	COG2814	Major facilitator Superfamily
HPG46_RS08465	COG1695	Transcriptional regulator
HPG46_RS08475	COG0477	Major facilitator Superfamily
HPG46_RS08480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS08490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPG46_RS08495	COG4166	transmembrane transport
HPG46_RS08500	COG2223	nitrite transmembrane transporter activity
HPG46_RS08505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPG46_RS08520	COG2244	polysaccharide biosynthetic process
HPG46_RS08525	COG0733	neurotransmitter:sodium symporter activity
HPG46_RS08535	COG5566	PFAM Mor transcription activator
HPG46_RS08540	COG2323	membrane
HPG46_RS08555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPG46_RS08565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_RS08570	COG0028	Belongs to the TPP enzyme family
HPG46_RS08575	COG0440	acetolactate synthase activity
HPG46_RS08580	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPG46_RS08590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPG46_RS08615	COG2814	Major facilitator Superfamily
HPG46_RS08620	COG3384	dioxygenase
HPG46_RS08630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPG46_RS08635	COG3279	Response regulator of the LytR AlgR family
HPG46_RS08640	COG0427	acetyl-CoA hydrolase
HPG46_RS08660	COG1073	alpha beta
HPG46_RS08665	COG4166	transmembrane transport
HPG46_RS08705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS08725	COG1914	H( )-stimulated, divalent metal cation uptake system
HPG46_RS08740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPG46_RS08745	COG0531	amino acid
HPG46_RS08770	COG2390	Transcriptional regulator
HPG46_RS08780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS08785	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPG46_RS08820	COG0006	proline dipeptidase activity
HPG46_RS08825	COG2132	Multicopper oxidase
HPG46_RS08860	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS08870	COG1276	copper resistance
HPG46_RS08870	COG2372	response to copper ion
HPG46_RS08875	COG4549	nuclear export factor GLE1
HPG46_RS08885	COG0697	spore germination
HPG46_RS08890	COG0583	DNA-binding transcription factor activity
HPG46_RS08895	COG1959	2 iron, 2 sulfur cluster binding
HPG46_RS08900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HPG46_RS08905	COG0778	Nitroreductase
HPG46_RS08920	COG0628	permease
HPG46_RS08930	COG1231	oxidoreductase activity
HPG46_RS08935	COG0523	cobalamin synthesis protein
HPG46_RS08950	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS08955	COG2030	dehydratase
HPG46_RS08960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS08970	COG0411	ABC transporter
HPG46_RS08990	COG0583	DNA-binding transcription factor activity
HPG46_RS09020	COG1271	oxidase subunit
HPG46_RS09025	COG1294	oxidase, subunit
HPG46_RS09030	COG4988	ABC transporter
HPG46_RS09035	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPG46_RS09050	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_RS09055	COG1686	Belongs to the peptidase S11 family
HPG46_RS09070	COG0791	NLP P60 protein
HPG46_RS09070	COG1388	LysM domain
HPG46_RS09080	COG1132	(ABC) transporter
HPG46_RS09085	COG0745	RESPONSE REGULATOR receiver
HPG46_RS09090	COG5002	protein histidine kinase activity
HPG46_RS09095	COG0300	oxidoreductase activity
HPG46_RS09100	COG4122	O-methyltransferase activity
HPG46_RS09115	COG5658	integral membrane protein
HPG46_RS09130	COG0460	homoserine dehydrogenase
HPG46_RS09155	COG1316	TRANSCRIPTIONal
HPG46_RS09165	COG0745	RESPONSE REGULATOR receiver
HPG46_RS09170	COG5002	protein histidine kinase activity
HPG46_RS09185	COG1285	pathogenesis
HPG46_RS09190	COG1247	-acetyltransferase
HPG46_RS09200	COG4264	IucA IucC family
HPG46_RS09205	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS09220	COG1082	Xylose isomerase domain protein TIM barrel
HPG46_RS09230	COG2814	Major facilitator Superfamily
HPG46_RS09235	COG1279	arginine transmembrane transporter activity
HPG46_RS09245	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPG46_RS09280	COG0577	efflux transmembrane transporter activity
HPG46_RS09285	COG2002	toxin-antitoxin pair type II binding
HPG46_RS09290	COG1404	Belongs to the peptidase S8 family
HPG46_RS09295	COG0640	Transcriptional regulator
HPG46_RS09300	COG0667	Aldo Keto reductase
HPG46_RS09305	COG2814	Major facilitator Superfamily
HPG46_RS09330	COG0840	transmembrane signaling receptor activity
HPG46_RS09345	COG3949	Membrane
HPG46_RS09350	COG0783	Belongs to the Dps family
HPG46_RS09365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPG46_RS09375	COG1231	oxidoreductase activity
HPG46_RS09385	COG4989	oxidoreductase activity
HPG46_RS09390	COG0523	cobalamin synthesis protein
HPG46_RS09395	COG0456	acetyltransferase
HPG46_RS09415	COG3443	Belongs to the bacterial solute-binding protein 9 family
HPG46_RS09415	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPG46_RS09425	COG0702	epimerase
HPG46_RS09435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPG46_RS09445	COG4166	transmembrane transport
HPG46_RS09460	COG0406	alpha-ribazole phosphatase activity
HPG46_RS09470	COG5337	Spore coat protein CotH
HPG46_RS09475	COG1051	belongs to the nudix hydrolase family
HPG46_RS09480	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS09485	COG2244	polysaccharide biosynthetic process
HPG46_RS09495	COG0701	Predicted permease
HPG46_RS09500	COG3689	TIGRFAM TIGR03943 family protein
HPG46_RS09505	COG1607	acyl-coa hydrolase
HPG46_RS09515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_RS09530	COG0702	epimerase
HPG46_RS09535	COG2839	Protein conserved in bacteria
HPG46_RS09540	COG1253	flavin adenine dinucleotide binding
HPG46_RS09555	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS09560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_RS09580	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS09590	COG1876	peptidase activity
HPG46_RS09600	COG0154	amidase activity
HPG46_RS09605	COG2211	Major facilitator Superfamily
HPG46_RS09620	COG2368	4-hydroxyphenylacetate
HPG46_RS09630	COG0196	riboflavin kinase activity
HPG46_RS09645	COG0251	oxidation-reduction process
HPG46_RS09655	COG3971	2-oxopent-4-enoate hydratase activity
HPG46_RS09675	COG1942	4-Oxalocrotonate Tautomerase
HPG46_RS09685	COG0561	phosphatase activity
HPG46_RS09695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPG46_RS09700	COG4106	trans-aconitate 2-methyltransferase activity
HPG46_RS09715	COG1819	glycosyl
HPG46_RS09720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS09725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS09755	COG0456	acetyltransferase
HPG46_RS09780	COG3874	Sporulation protein YtfJ
HPG46_RS09805	COG2226	methyltransferase
HPG46_RS09825	COG1082	Xylose isomerase domain protein TIM barrel
HPG46_RS09830	COG0346	lactoylglutathione lyase activity
HPG46_RS09840	COG0604	alcohol dehydrogenase
HPG46_RS09845	COG1595	DNA-templated transcription, initiation
HPG46_RS09860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPG46_RS09880	COG0386	Belongs to the glutathione peroxidase family
HPG46_RS09885	COG1305	Transglutaminase-like
HPG46_RS09890	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HPG46_RS09895	COG0714	Associated with various cellular activities
HPG46_RS09910	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPG46_RS09915	COG1140	nitrate reductase beta subunit
HPG46_RS09920	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPG46_RS09925	COG2181	nitrate reductase activity
HPG46_RS09930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPG46_RS09935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPG46_RS09940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_RS09945	COG0303	'Molybdopterin
HPG46_RS09950	COG0314	molybdopterin synthase activity
HPG46_RS09960	COG2223	nitrite transmembrane transporter activity
HPG46_RS09975	COG1648	precorrin-2 dehydrogenase activity
HPG46_RS09985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPG46_RS09985	COG1587	Uroporphyrinogen-III synthase
HPG46_RS09990	COG2146	nitrite reductase [NAD(P)H] activity
HPG46_RS09995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPG46_RS10000	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HPG46_RS10025	COG2359	stage V sporulation protein S
HPG46_RS10060	COG1418	mRNA catabolic process
HPG46_RS10065	COG0488	(ABC) transporter
HPG46_RS10080	COG0629	single-stranded DNA binding
HPG46_RS10085	COG1413	lyase activity
HPG46_RS10100	COG2136	Putative SAM-dependent methyltransferase
HPG46_RS10100	COG2521	methyltransferase
HPG46_RS10130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPG46_RS10150	COG0017	Asparaginyl-tRNA synthetase
HPG46_RS10170	COG1674	ftsk spoiiie
HPG46_RS10280	COG1929	Belongs to the glycerate kinase type-1 family
HPG46_RS10285	COG0471	metal ion transport
HPG46_RS10290	COG0745	RESPONSE REGULATOR receiver
HPG46_RS10295	COG5002	protein histidine kinase activity
HPG46_RS10295	COG3850	Histidine kinase
HPG46_RS10310	COG0733	neurotransmitter:sodium symporter activity
HPG46_RS10335	COG2610	gluconate transmembrane transporter activity
HPG46_RS10340	COG1454	alcohol dehydrogenase
HPG46_RS10345	COG1794	racemase activity, acting on amino acids and derivatives
HPG46_RS10355	COG0456	acetyltransferase
HPG46_RS10360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPG46_RS10370	COG1131	(ABC) transporter
HPG46_RS10375	COG4473	ABC transporter
HPG46_RS10385	COG0546	phosphoglycolate phosphatase activity
HPG46_RS10405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_RS10410	COG3250	beta-galactosidase activity
HPG46_RS10425	COG0768	penicillin binding
HPG46_RS10435	COG0204	Acyl-transferase
HPG46_RS10440	COG1272	protein, Hemolysin III
HPG46_RS10450	COG0805	protein transport
HPG46_RS10460	COG1307	EDD domain protein, DegV family
HPG46_RS10465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HPG46_RS10470	COG1999	signal sequence binding
HPG46_RS10475	COG0071	Belongs to the small heat shock protein (HSP20) family
HPG46_RS10480	COG0367	asparagine synthase
HPG46_RS10495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS10500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_RS10520	COG1335	isochorismatase
HPG46_RS10525	COG1051	belongs to the nudix hydrolase family
HPG46_RS10530	COG0071	Belongs to the small heat shock protein (HSP20) family
HPG46_RS10535	COG0668	transmembrane transport
HPG46_RS10540	COG2203	Gaf domain
HPG46_RS10540	COG4585	Histidine kinase
HPG46_RS10545	COG2197	response regulator
HPG46_RS10555	COG1064	alcohol dehydrogenase
HPG46_RS10580	COG1070	Carbohydrate kinase
HPG46_RS10585	COG1070	Carbohydrate kinase
HPG46_RS10615	COG0517	IMP dehydrogenase activity
HPG46_RS10615	COG1125	glycine betaine transport
HPG46_RS10620	COG1174	glycine betaine transport
HPG46_RS10655	COG1253	flavin adenine dinucleotide binding
HPG46_RS10660	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS10665	COG5506	Protein of unknown function (DUF1694)
HPG46_RS10680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPG46_RS10685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPG46_RS10690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPG46_RS10695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPG46_RS10700	COG0456	acetyltransferase
HPG46_RS10705	COG3829	transcription factor binding
HPG46_RS10710	COG1509	lysine 2,3-aminomutase activity
HPG46_RS10750	COG4326	sporulation control protein
HPG46_RS10755	COG0671	phosphoesterase, PA-phosphatase related
HPG46_RS10760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPG46_RS10765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_RS10825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPG46_RS10855	COG0300	oxidoreductase activity
HPG46_RS10875	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPG46_RS10875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_RS10880	COG2814	Major facilitator Superfamily
HPG46_RS10885	COG4841	protein insertion into membrane
HPG46_RS10890	COG0372	Belongs to the citrate synthase family
HPG46_RS10895	COG2079	MmgE PrpD family protein
HPG46_RS10900	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPG46_RS10905	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS10910	COG2084	Dehydrogenase
HPG46_RS10920	COG1280	lysine exporter protein (LysE YggA)
HPG46_RS10925	COG1024	Enoyl-CoA hydratase
HPG46_RS10940	COG0420	3'-5' exonuclease activity
HPG46_RS10945	COG0419	ATPase involved in DNA repair
HPG46_RS10960	COG2223	nitrite transmembrane transporter activity
HPG46_RS10965	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS10970	COG1169	isochorismate synthase
HPG46_RS10975	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPG46_RS10980	COG3433	isochorismatase activity
HPG46_RS10980	COG1535	isochorismatase
HPG46_RS10985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPG46_RS10990	COG3251	PFAM MbtH domain protein
HPG46_RS10995	COG2814	Major facilitator Superfamily
HPG46_RS11010	COG0776	regulation of translation
HPG46_RS11020	COG2318	DinB family
HPG46_RS11030	COG1115	amino acid carrier protein
HPG46_RS11045	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_RS11050	COG1187	pseudouridine synthase activity
HPG46_RS11055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPG46_RS11060	COG1136	(ABC) transporter
HPG46_RS11070	COG0596	Alpha beta hydrolase
HPG46_RS11075	COG2814	Major facilitator Superfamily
HPG46_RS11095	COG2226	methyltransferase
HPG46_RS11125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPG46_RS11140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS11175	COG1247	-acetyltransferase
HPG46_RS11215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS11225	COG1278	Cold shock
HPG46_RS11240	COG0010	Belongs to the arginase family
HPG46_RS11245	COG0561	phosphatase activity
HPG46_RS11295	COG0583	DNA-binding transcription factor activity
HPG46_RS11300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPG46_RS11315	COG0583	DNA-binding transcription factor activity
HPG46_RS11320	COG2258	MOSC domain
HPG46_RS11335	COG1132	(ABC) transporter
HPG46_RS11340	COG1132	(ABC) transporter
HPG46_RS11360	COG1396	sequence-specific DNA binding
HPG46_RS11390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPG46_RS11400	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPG46_RS11405	COG1595	DNA-templated transcription, initiation
HPG46_RS11430	COG1649	PFAM Uncharacterised BCR, COG1649
HPG46_RS11455	COG2971	BadF BadG BcrA BcrD
HPG46_RS11465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPG46_RS11490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS11520	COG1309	transcriptional regulator
HPG46_RS11535	COG1136	(ABC) transporter
HPG46_RS11535	COG0577	efflux transmembrane transporter activity
HPG46_RS11540	COG3615	Tellurite resistance protein tehB
HPG46_RS11540	COG0500	methyltransferase
HPG46_RS11550	COG3961	Belongs to the TPP enzyme family
HPG46_RS11555	COG1846	Transcriptional regulator
HPG46_RS11595	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPG46_RS11610	COG1595	DNA-templated transcription, initiation
HPG46_RS11620	COG0768	penicillin binding
HPG46_RS11630	COG2367	Beta-lactamase
HPG46_RS11635	COG0671	phosphoesterase, PA-phosphatase related
HPG46_RS11640	COG1609	Transcriptional regulator
HPG46_RS11645	COG2814	Major facilitator Superfamily
HPG46_RS11650	COG0673	inositol 2-dehydrogenase activity
HPG46_RS11675	COG0191	fructose-bisphosphate aldolase activity
HPG46_RS11680	COG3718	enzyme involved in inositol metabolism
HPG46_RS11690	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS11700	COG0457	Tetratricopeptide repeat
HPG46_RS11715	COG1876	peptidase activity
HPG46_RS11735	COG1309	transcriptional regulator
HPG46_RS11775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS11810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS11840	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS11845	COG0439	Biotin carboxylase
HPG46_RS11850	COG0511	ligase activity, forming carbon-carbon bonds
HPG46_RS11855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPG46_RS11860	COG1024	Enoyl-CoA hydratase
HPG46_RS11865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPG46_RS11870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPG46_RS11880	COG1247	-acetyltransferase
HPG46_RS11885	COG0572	uridine kinase
HPG46_RS11895	COG1686	Belongs to the peptidase S11 family
HPG46_RS11920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPG46_RS11940	COG3227	Zinc metalloprotease (Elastase)
HPG46_RS11960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPG46_RS11985	COG2814	Major facilitator Superfamily
HPG46_RS12025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS12045	COG1063	alcohol dehydrogenase
HPG46_RS12065	COG3386	PFAM SMP-30 Gluconolaconase
HPG46_RS12075	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HPG46_RS12080	COG3773	Cell wall hydrolase
HPG46_RS12090	COG0745	RESPONSE REGULATOR receiver
HPG46_RS12095	COG2205	protein histidine kinase activity
HPG46_RS12120	COG1136	(ABC) transporter
HPG46_RS12125	COG0577	efflux transmembrane transporter activity
HPG46_RS12145	COG0460	homoserine dehydrogenase
HPG46_RS12150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS12160	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPG46_RS12185	COG0582	viral genome integration into host DNA
HPG46_RS12200	COG1396	sequence-specific DNA binding
HPG46_RS12230	COG1484	DNA-dependent DNA replication
HPG46_RS12315	COG0582	viral genome integration into host DNA
HPG46_RS12500	COG2124	cytochrome p450
HPG46_RS12535	COG0561	phosphatase activity
HPG46_RS12540	COG5002	protein histidine kinase activity
HPG46_RS12550	COG1819	glycosyl
HPG46_RS12555	COG1794	racemase activity, acting on amino acids and derivatives
HPG46_RS12565	COG1122	ATPase activity
HPG46_RS12580	COG2205	protein histidine kinase activity
HPG46_RS12590	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPG46_RS12595	COG0604	alcohol dehydrogenase
HPG46_RS12600	COG0671	phosphoesterase, PA-phosphatase related
HPG46_RS12615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_RS12670	COG2814	Major facilitator Superfamily
HPG46_RS12685	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_RS12700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS12705	COG0697	spore germination
HPG46_RS12745	COG2223	nitrite transmembrane transporter activity
HPG46_RS12760	COG2816	NAD+ diphosphatase activity
HPG46_RS12765	COG0592	DNA-directed DNA polymerase activity
HPG46_RS12770	COG1051	belongs to the nudix hydrolase family
HPG46_RS12800	COG3878	Protein conserved in bacteria
HPG46_RS12820	COG4667	esterase of the alpha-beta hydrolase superfamily
HPG46_RS12845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPG46_RS12860	COG0322	excinuclease ABC activity
HPG46_RS12900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_RS12925	COG1011	Hydrolase
HPG46_RS12945	COG1523	belongs to the glycosyl hydrolase 13 family
HPG46_RS12950	COG3227	Zinc metalloprotease (Elastase)
HPG46_RS12970	COG0201	protein transport
HPG46_RS12980	COG0697	spore germination
HPG46_RS12985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS13025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS13040	COG2959	enzyme of heme biosynthesis
HPG46_RS13065	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HPG46_RS13070	COG3844	kynureninase activity
HPG46_RS13075	COG1309	transcriptional regulator
HPG46_RS13105	COG3284	Transcriptional regulator
HPG46_RS13125	COG1349	DNA-binding transcription factor activity
HPG46_RS13145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPG46_RS13150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPG46_RS13155	COG0022	dehydrogenase e1 component
HPG46_RS13160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPG46_RS13170	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS13175	COG0456	acetyltransferase
HPG46_RS13175	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPG46_RS13185	COG0494	nUDIX hydrolase
HPG46_RS13210	COG4176	ABC-type proline glycine betaine transport system permease component
HPG46_RS13215	COG4175	Glycine betaine
HPG46_RS13215	COG0517	IMP dehydrogenase activity
HPG46_RS13245	COG2153	protein acetylation
HPG46_RS13250	COG3397	chitin binding
HPG46_RS13265	COG2205	protein histidine kinase activity
HPG46_RS13270	COG2226	methyltransferase
HPG46_RS13285	COG2333	competence protein COMEC
HPG46_RS13285	COG0658	competence protein
HPG46_RS13335	COG3973	AAA domain
HPG46_RS13350	COG2105	PFAM AIG2 family protein
HPG46_RS13355	COG0514	ATP-dependent DNA helicase (RecQ)
HPG46_RS13385	COG4637	Psort location Cytoplasmic, score
HPG46_RS13405	COG3397	chitin binding
HPG46_RS13420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPG46_RS13425	COG1115	amino acid carrier protein
HPG46_RS13430	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS13435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPG46_RS13445	COG3938	Belongs to the proline racemase family
HPG46_RS13450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_RS13500	COG1078	dGTPase activity
HPG46_RS13505	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS13520	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HPG46_RS13525	COG0519	Catalyzes the synthesis of GMP from XMP
HPG46_RS13530	COG4166	transmembrane transport
HPG46_RS13540	COG4948	Mandelate Racemase Muconate Lactonizing
HPG46_RS13580	COG2936	dipeptidyl-peptidase activity
HPG46_RS13585	COG5002	protein histidine kinase activity
HPG46_RS13590	COG0745	RESPONSE REGULATOR receiver
HPG46_RS13625	COG1164	Oligoendopeptidase f
HPG46_RS13640	COG1307	EDD domain protein, DegV family
HPG46_RS13675	COG2814	Major facilitator Superfamily
HPG46_RS13685	COG1664	Polymer-forming cytoskeletal
HPG46_RS13690	COG0789	Transcriptional regulator
HPG46_RS13695	COG4533	DNA binding
HPG46_RS13700	COG0477	Major facilitator Superfamily
HPG46_RS13700	COG2814	Major facilitator Superfamily
HPG46_RS13720	COG2261	transglycosylase associated protein
HPG46_RS13735	COG2226	methyltransferase
HPG46_RS13770	COG0436	Aminotransferase
HPG46_RS13775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPG46_RS13780	COG5146	pantothenate kinase activity
HPG46_RS13785	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HPG46_RS13845	COG0628	permease
HPG46_RS13855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPG46_RS13860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_RS13865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPG46_RS13870	COG1116	anion transmembrane transporter activity
HPG46_RS13910	COG2746	aminoglycoside 3-N-acetyltransferase activity
HPG46_RS13935	COG0697	spore germination
HPG46_RS13940	COG2318	DinB family
HPG46_RS13960	COG4912	Dna alkylation repair
HPG46_RS13980	COG0861	Integral membrane protein TerC family
HPG46_RS13985	COG1368	sulfuric ester hydrolase activity
HPG46_RS13990	COG0488	(ABC) transporter
HPG46_RS14000	COG1033	growth of symbiont in host cell
HPG46_RS14000	COG2409	Drug exporters of the RND superfamily
HPG46_RS14005	COG1309	transcriptional regulator
HPG46_RS14020	COG0287	Prephenate dehydrogenase
HPG46_RS14025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPG46_RS14035	COG1605	Chorismate mutase
HPG46_RS14035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HPG46_RS14070	COG1388	LysM domain
HPG46_RS14070	COG3584	3D domain protein
HPG46_RS14080	COG1595	DNA-templated transcription, initiation
HPG46_RS14105	COG1879	ABC-type sugar transport system periplasmic component
HPG46_RS14115	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPG46_RS14125	COG2390	Transcriptional regulator
HPG46_RS14130	COG1070	Carbohydrate kinase
HPG46_RS14160	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_RS14180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS14190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPG46_RS14195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_RS14200	COG4187	Peptidase family M20/M25/M40
HPG46_RS14205	COG1414	Transcriptional regulator
HPG46_RS14210	COG0833	amino acid
HPG46_RS14220	COG3239	Fatty acid desaturase
HPG46_RS14225	COG1785	Belongs to the alkaline phosphatase family
HPG46_RS14235	COG3655	Transcriptional regulator
HPG46_RS14250	COG4377	Putative membrane peptidase family (DUF2324)
HPG46_RS14260	COG3279	Response regulator of the LytR AlgR family
HPG46_RS14270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS14275	COG0346	lactoylglutathione lyase activity
HPG46_RS14295	COG0714	Associated with various cellular activities
HPG46_RS14320	COG0463	Glycosyl transferase, family 2
HPG46_RS14335	COG0463	Glycosyl transferase, family 2
HPG46_RS14345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPG46_RS14350	COG0753	catalase activity
HPG46_RS14360	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HPG46_RS14385	COG0714	Associated with various cellular activities
HPG46_RS14395	COG0778	Nitroreductase
HPG46_RS14400	COG1846	Transcriptional regulator
HPG46_RS14420	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPG46_RS14440	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS14445	COG0183	Belongs to the thiolase family
HPG46_RS14450	COG1024	Enoyl-CoA hydratase
HPG46_RS14455	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPG46_RS14460	COG2723	6-phospho-beta-galactosidase activity
HPG46_RS14465	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_RS14470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_RS14485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_RS14495	COG2508	Transcriptional regulator
HPG46_RS14500	COG2814	Major facilitator Superfamily
HPG46_RS14505	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPG46_RS14535	COG1725	Transcriptional regulator
HPG46_RS14545	COG1136	(ABC) transporter
HPG46_RS14570	COG2207	Transcriptional regulator
HPG46_RS14575	COG0456	acetyltransferase
HPG46_RS14595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS14645	COG0730	response to heat
HPG46_RS14655	COG0833	amino acid
HPG46_RS14665	COG4335	DNA alkylation repair
HPG46_RS14725	COG1984	allophanate hydrolase subunit 2
HPG46_RS14730	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPG46_RS14735	COG1414	Transcriptional regulator
HPG46_RS14755	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS14760	COG0640	Transcriptional regulator
HPG46_RS14770	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS14815	COG0574	Belongs to the PEP-utilizing enzyme family
HPG46_RS14815	COG3848	Pyruvate phosphate dikinase
HPG46_RS14820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS14835	COG5577	PFAM Coat F domain
HPG46_RS14840	COG3403	YqcI/YcgG family
HPG46_RS14845	COG1280	lysine exporter protein (LysE YggA)
HPG46_RS14850	COG1113	amino acid transport
HPG46_RS14880	COG1063	alcohol dehydrogenase
HPG46_RS14890	COG1027	Aspartate ammonia-lyase
HPG46_RS14895	COG0252	asparaginase activity
HPG46_RS14900	COG1396	sequence-specific DNA binding
HPG46_RS14915	COG0531	amino acid
HPG46_RS14920	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS14925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_RS14945	COG0784	Response regulator, receiver
HPG46_RS14950	COG4191	Histidine kinase
HPG46_RS14955	COG2066	Belongs to the glutaminase family
HPG46_RS14960	COG1115	amino acid carrier protein
HPG46_RS15000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_RS15000	COG0723	plastoquinol--plastocyanin reductase activity
HPG46_RS15005	COG0534	Mate efflux family protein
HPG46_RS15015	COG0531	amino acid
HPG46_RS15020	COG4085	toxin activity
HPG46_RS15020	COG1525	nuclease
HPG46_RS15020	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS15025	COG0753	catalase activity
HPG46_RS15030	COG2267	carboxylic ester hydrolase activity
HPG46_RS15035	COG1335	isochorismatase
HPG46_RS15055	COG0583	DNA-binding transcription factor activity
HPG46_RS15060	COG1846	Transcriptional regulator
HPG46_RS15065	COG0598	Magnesium transport protein CorA
HPG46_RS15100	COG0415	Belongs to the DNA photolyase family
HPG46_RS15105	COG0288	reversible hydration of carbon dioxide
HPG46_RS15115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPG46_RS15120	COG5609	conserved protein (DUF2294)
HPG46_RS15135	COG0714	Associated with various cellular activities
HPG46_RS15145	COG1575	Belongs to the MenA family. Type 1 subfamily
HPG46_RS15170	COG4641	Protein conserved in bacteria
HPG46_RS15200	COG0798	PFAM Bile acid sodium symporter
HPG46_RS15205	COG0346	lactoylglutathione lyase activity
HPG46_RS15210	COG0640	Transcriptional regulator
HPG46_RS15230	COG5002	protein histidine kinase activity
HPG46_RS15235	COG0745	RESPONSE REGULATOR receiver
HPG46_RS15240	COG0456	acetyltransferase
HPG46_RS15255	COG1309	transcriptional regulator
HPG46_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS15280	COG0346	lactoylglutathione lyase activity
HPG46_RS15300	COG2169	Transcriptional regulator
HPG46_RS15345	COG2814	Major facilitator Superfamily
HPG46_RS15370	COG0745	RESPONSE REGULATOR receiver
HPG46_RS15375	COG3850	Histidine kinase
HPG46_RS15375	COG5002	protein histidine kinase activity
HPG46_RS15400	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HPG46_RS15425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS15430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPG46_RS15440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS15445	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HPG46_RS15465	COG0577	efflux transmembrane transporter activity
HPG46_RS15480	COG5002	protein histidine kinase activity
HPG46_RS15480	COG3850	Histidine kinase
HPG46_RS15490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS15495	COG2271	Major facilitator Superfamily
HPG46_RS15500	COG1556	Lactate utilization protein
HPG46_RS15505	COG1139	Iron-sulfur cluster binding protein
HPG46_RS15515	COG0583	DNA-binding transcription factor activity
HPG46_RS15535	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_RS15550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPG46_RS15570	COG1595	DNA-templated transcription, initiation
HPG46_RS15585	COG0662	Cupin 2, conserved barrel domain protein
HPG46_RS15590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS15590	COG2207	Transcriptional regulator
HPG46_RS15605	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS15605	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_RS15645	COG0477	Major facilitator Superfamily
HPG46_RS15655	COG1846	Transcriptional regulator
HPG46_RS15660	COG2814	Major facilitator Superfamily
HPG46_RS15670	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPG46_RS15675	COG1131	(ABC) transporter
HPG46_RS15695	COG2076	Multidrug Resistance protein
HPG46_RS15700	COG1309	transcriptional regulator
HPG46_RS15715	COG2031	fatty acid transporter
HPG46_RS15725	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPG46_RS15755	COG1122	ATPase activity
HPG46_RS15760	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPG46_RS15775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPG46_RS15780	COG1288	antiporter activity
HPG46_RS15785	COG2356	endonuclease I
HPG46_RS15800	COG3620	sequence-specific DNA binding
HPG46_RS15810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPG46_RS15830	COG1733	regulation of RNA biosynthetic process
HPG46_RS15835	COG0778	Nitroreductase
HPG46_RS15855	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS15865	COG1131	(ABC) transporter
HPG46_RS15890	COG1011	Hydrolase
HPG46_RS15925	COG0346	lactoylglutathione lyase activity
HPG46_RS15930	COG1940	carbohydrate kinase activity
HPG46_RS15935	COG0738	Major facilitator superfamily
HPG46_RS15940	COG0110	maltose O-acetyltransferase activity
HPG46_RS15955	COG0628	permease
HPG46_RS15975	COG2226	methyltransferase
HPG46_RS15985	COG0477	Major facilitator Superfamily
HPG46_RS16015	COG1253	flavin adenine dinucleotide binding
HPG46_RS16020	COG0789	Transcriptional regulator
HPG46_RS16030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPG46_RS16060	COG0697	spore germination
HPG46_RS16065	COG1357	PFAM Pentapeptide repeats (8 copies)
HPG46_RS16070	COG3813	Protein conserved in bacteria
HPG46_RS16075	COG2706	6-phosphogluconolactonase activity
HPG46_RS16080	COG1070	Carbohydrate kinase
HPG46_RS16090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPG46_RS16095	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HPG46_RS16105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPG46_RS16110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPG46_RS16115	COG0604	alcohol dehydrogenase
HPG46_RS16120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPG46_RS16135	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS16155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_RS16155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_RS16160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPG46_RS16160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPG46_RS16165	COG1733	regulation of RNA biosynthetic process
HPG46_RS16180	COG0656	L-ascorbic acid biosynthetic process
HPG46_RS16185	COG2814	Major facilitator Superfamily
HPG46_RS16200	COG0346	lactoylglutathione lyase activity
HPG46_RS16205	COG0814	amino acid
HPG46_RS16235	COG1393	Belongs to the ArsC family
HPG46_RS16240	COG1733	regulation of RNA biosynthetic process
HPG46_RS16245	COG2188	Transcriptional regulator
HPG46_RS16250	COG0673	inositol 2-dehydrogenase activity
HPG46_RS16255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPG46_RS16260	COG1733	regulation of RNA biosynthetic process
HPG46_RS16265	COG1733	regulation of RNA biosynthetic process
HPG46_RS16285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS16305	COG0384	phenazine biosynthesis protein PhzF
HPG46_RS16315	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS16330	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS16335	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPG46_RS16340	COG1733	regulation of RNA biosynthetic process
HPG46_RS16360	COG1191	sigma factor activity
HPG46_RS16375	COG1309	transcriptional regulator
HPG46_RS16395	COG3152	Membrane
HPG46_RS16420	COG1151	hydroxylamine reductase activity
HPG46_RS16430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS16435	COG3757	hydrolase, family 25
HPG46_RS16435	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_RS16470	COG2072	flavoprotein involved in K transport
HPG46_RS16510	COG1113	amino acid transport
HPG46_RS16515	COG2814	Major facilitator Superfamily
HPG46_RS16545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPG46_RS16550	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPG46_RS16565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS16570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS16575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS16580	COG3739	integral membrane protein
HPG46_RS16585	COG0384	phenazine biosynthesis protein PhzF
HPG46_RS16615	COG0583	DNA-binding transcription factor activity
HPG46_RS16635	COG1193	negative regulation of DNA recombination
HPG46_RS16650	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HPG46_RS16655	COG1164	Oligoendopeptidase f
HPG46_RS16660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_RS16690	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_RS16715	COG0640	Transcriptional regulator
HPG46_RS16720	COG0604	alcohol dehydrogenase
HPG46_RS16730	COG0457	Tetratricopeptide repeat
HPG46_RS16740	COG0385	Bile acid
HPG46_RS16745	COG0277	FAD linked oxidase domain protein
HPG46_RS16780	COG1216	Glycosyl transferase, family 2
HPG46_RS16785	COG1024	Enoyl-CoA hydratase
HPG46_RS16795	COG1285	pathogenesis
HPG46_RS16810	COG2514	catechol 2,3-dioxygenase activity
HPG46_RS16815	COG2720	vancomycin resistance protein
HPG46_RS16855	COG0716	FMN binding
HPG46_RS16885	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS16895	COG0165	Argininosuccinate lyase
HPG46_RS16910	COG4145	pantothenate transmembrane transporter activity
HPG46_RS16920	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS16925	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS16935	COG1657	PFAM Prenyltransferase squalene oxidase
HPG46_RS16940	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HPG46_RS16945	COG2962	Rard protein
HPG46_RS16950	COG3326	Membrane
HPG46_RS16965	COG0489	protein tyrosine kinase activity
HPG46_RS16975	COG0314	molybdopterin synthase activity
HPG46_RS16980	COG0303	'Molybdopterin
HPG46_RS16985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_RS16990	COG2116	formate transmembrane transporter activity
HPG46_RS17000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPG46_RS17005	COG5609	conserved protein (DUF2294)
HPG46_RS17010	COG2427	Protein of unknown function (DUF1641)
HPG46_RS17015	COG3383	formate dehydrogenase (NAD+) activity
HPG46_RS17020	COG0697	spore germination
HPG46_RS17060	COG2226	methyltransferase
HPG46_RS17065	COG4166	transmembrane transport
HPG46_RS17070	COG4166	transmembrane transport
HPG46_RS17075	COG4166	transmembrane transport
HPG46_RS17080	COG1301	dicarboxylic acid transport
HPG46_RS17085	COG1316	TRANSCRIPTIONal
HPG46_RS17095	COG1595	DNA-templated transcription, initiation
HPG46_RS17115	COG1131	(ABC) transporter
HPG46_RS17125	COG0673	inositol 2-dehydrogenase activity
HPG46_RS17130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPG46_RS17135	COG0187	DNA topoisomerase II activity
HPG46_RS17140	COG1832	CoA-binding protein
HPG46_RS17145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPG46_RS17150	COG0745	RESPONSE REGULATOR receiver
HPG46_RS17170	COG4841	protein insertion into membrane
HPG46_RS17175	COG0824	Thioesterase
HPG46_RS17205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_RS17215	COG1132	(ABC) transporter
HPG46_RS17220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPG46_RS17260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPG46_RS17275	COG0183	Belongs to the thiolase family
HPG46_RS17280	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS17285	COG1268	BioY protein
HPG46_RS17290	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS17340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS17350	COG5002	protein histidine kinase activity
HPG46_RS17355	COG0400	carboxylic ester hydrolase activity
HPG46_RS17360	COG0346	lactoylglutathione lyase activity
HPG46_RS17365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_RS17370	COG0069	glutamate synthase activity
HPG46_RS17375	COG1902	pentaerythritol trinitrate reductase activity
HPG46_RS17380	COG1329	Transcriptional regulator
HPG46_RS17385	COG0010	Belongs to the arginase family
HPG46_RS17410	COG2226	methyltransferase
HPG46_RS17445	COG4846	Membrane protein involved in cytochrome C biogenesis
HPG46_RS17450	COG0785	Cytochrome C biogenesis protein
HPG46_RS17460	COG1473	amidohydrolase
HPG46_RS17470	COG1131	(ABC) transporter
HPG46_RS17480	COG0583	DNA-binding transcription factor activity
HPG46_RS17490	COG1346	cytolysis
HPG46_RS17505	COG0730	response to heat
HPG46_RS17515	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS17515	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_RS17530	COG1132	(ABC) transporter
HPG46_RS17535	COG1132	(ABC) transporter
HPG46_RS17560	COG3639	organic phosphonate transmembrane transporter activity
HPG46_RS17575	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS17585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPG46_RS17605	COG1695	Transcriptional regulator
HPG46_RS17615	COG0174	glutamine synthetase
HPG46_RS17620	COG0789	Transcriptional regulator
HPG46_RS17625	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HPG46_RS17630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPG46_RS17635	COG2860	membrane
HPG46_RS17640	COG0464	growth
HPG46_RS17670	COG1388	LysM domain
HPG46_RS17670	COG3584	3D domain protein
HPG46_RS17675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_RS17675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPG46_RS17675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPG46_RS17680	COG1105	Belongs to the carbohydrate kinase PfkB family
HPG46_RS17685	COG1349	DNA-binding transcription factor activity
HPG46_RS17690	COG1979	alcohol dehydrogenase
HPG46_RS17695	COG2322	membrane
HPG46_RS17705	COG1113	amino acid transport
HPG46_RS17720	COG1408	metallophosphoesterase
HPG46_RS17725	COG2116	formate transmembrane transporter activity
HPG46_RS17740	COG2217	Heavy metal translocating P-type atpase
HPG46_RS17745	COG2608	mercury ion transmembrane transporter activity
HPG46_RS17750	COG1937	Protein conserved in bacteria
HPG46_RS17760	COG2819	hydrolase of the alpha beta superfamily
HPG46_RS17765	COG1120	ATPase activity
HPG46_RS17770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS17775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS17780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS17785	COG0708	Exodeoxyribonuclease III
HPG46_RS17795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPG46_RS17800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPG46_RS17810	COG2364	Membrane
HPG46_RS17825	COG2267	carboxylic ester hydrolase activity
HPG46_RS17830	COG0346	lactoylglutathione lyase activity
HPG46_RS17835	COG5001	Diguanylate cyclase
HPG46_RS17835	COG3300	MHYT domain
HPG46_RS17850	COG1346	cytolysis
HPG46_RS17855	COG1380	Effector of murein hydrolase LrgA
HPG46_RS17860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS17870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPG46_RS17890	COG1404	Belongs to the peptidase S8 family
HPG46_RS17895	COG3773	Cell wall hydrolase
HPG46_RS17900	COG0562	UDP-galactopyranose mutase
HPG46_RS17905	COG1368	sulfuric ester hydrolase activity
HPG46_RS17910	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPG46_RS17920	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HPG46_RS17940	COG4550	Control of competence regulator ComK, YlbF/YmcA
HPG46_RS17950	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPG46_RS17955	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPG46_RS17955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPG46_RS17965	COG2359	stage V sporulation protein S
HPG46_RS17970	COG1692	metallophosphoesterase
HPG46_RS17995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPG46_RS18000	COG1426	Protein conserved in bacteria
HPG46_RS18015	COG0300	oxidoreductase activity
HPG46_RS18020	COG0612	Peptidase, M16
HPG46_RS18025	COG0612	Peptidase, M16
HPG46_RS18050	COG2188	Transcriptional regulator
HPG46_RS18055	COG1674	ftsk spoiiie
HPG46_RS18065	COG0740	serine-type endopeptidase activity
HPG46_RS18070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPG46_RS18080	COG0527	aspartate kinase activity
HPG46_RS18085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPG46_RS18090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPG46_RS18095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPG46_RS18100	COG1873	PFAM PRC-barrel domain
HPG46_RS18105	COG0612	Peptidase, M16
HPG46_RS18110	COG0726	polysaccharide deacetylase
HPG46_RS18125	COG0196	riboflavin kinase activity
HPG46_RS18130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPG46_RS18140	COG1550	Protein conserved in bacteria
HPG46_RS18150	COG1358	cellular component organization or biogenesis
HPG46_RS18155	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HPG46_RS18160	COG0195	Participates in both transcription termination and antitermination
HPG46_RS18180	COG0750	zinc metalloprotease
HPG46_RS18190	COG4589	Belongs to the CDS family
HPG46_RS18205	COG0528	UMP kinase activity
HPG46_RS18235	COG4974	Belongs to the 'phage' integrase family
HPG46_RS18245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPG46_RS18250	COG0758	DNA mediated transformation
HPG46_RS18255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPG46_RS18295	COG1837	Belongs to the UPF0109 family
HPG46_RS18305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPG46_RS18315	COG0552	protein localization to endoplasmic reticulum
HPG46_RS18320	COG1196	nuclear chromosome segregation
HPG46_RS18330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPG46_RS18335	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS18340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPG46_RS18355	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPG46_RS18360	COG1461	Dihydroxyacetone kinase
HPG46_RS18365	COG1302	Protein conserved in bacteria
HPG46_RS18380	COG1564	THIamine pyrophosphokinase
HPG46_RS18385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPG46_RS18390	COG1162	GTPase activity
HPG46_RS18395	COG0515	serine threonine protein kinase
HPG46_RS18395	COG2815	serine threonine protein kinase
HPG46_RS18400	COG0631	protein serine/threonine phosphatase activity
HPG46_RS18410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPG46_RS18410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPG46_RS18420	COG0242	peptide deformylase activity
HPG46_RS18425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPG46_RS18430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPG46_RS18450	COG1561	YicC-like family, N-terminal region
HPG46_RS18455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPG46_RS18465	COG0006	proline dipeptidase activity
HPG46_RS18485	COG3069	C4-dicarboxylate transmembrane transporter activity
HPG46_RS18495	COG1011	Hydrolase
HPG46_RS18550	COG0564	pseudouridine synthase activity
HPG46_RS18570	COG3599	regulation of cell shape
HPG46_RS18575	COG2302	S4 RNA-binding domain
HPG46_RS18580	COG0762	integral membrane protein
HPG46_RS18590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPG46_RS18600	COG1873	PFAM PRC-barrel domain
HPG46_RS18605	COG1191	sigma factor activity
HPG46_RS18610	COG1191	sigma factor activity
HPG46_RS18620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPG46_RS18625	COG0849	cell division
HPG46_RS18630	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPG46_RS18635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPG46_RS18645	COG0772	Belongs to the SEDS family
HPG46_RS18660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPG46_RS18665	COG0768	penicillin binding
HPG46_RS18675	COG4839	cell division protein FtsL
HPG46_RS18690	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPG46_RS18705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPG46_RS18710	COG1399	metal-binding, possibly nucleic acid-binding protein
HPG46_RS18720	COG3480	Lon protease (S16) C-terminal proteolytic domain
HPG46_RS18725	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPG46_RS18730	COG3314	Sporulation integral membrane protein YlbJ
HPG46_RS18740	COG0742	ribosomal rna small subunit methyltransferase
HPG46_RS18755	COG3679	Belongs to the UPF0342 family
HPG46_RS18760	COG0406	alpha-ribazole phosphatase activity
HPG46_RS18775	COG2340	Cysteine-rich secretory protein family
HPG46_RS18790	COG3336	cytochrome c oxidase
HPG46_RS18825	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HPG46_RS18830	COG0772	Belongs to the SEDS family
HPG46_RS18840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPG46_RS18845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPG46_RS18855	COG4896	Protein conserved in bacteria
HPG46_RS18880	COG0483	inositol monophosphate 1-phosphatase activity
HPG46_RS18900	COG1982	Orn Lys Arg decarboxylase major
HPG46_RS18950	COG0022	dehydrogenase e1 component
HPG46_RS18955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPG46_RS18965	COG0242	peptide deformylase activity
HPG46_RS18970	COG0561	phosphatase activity
HPG46_RS18980	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPG46_RS18985	COG0569	domain protein
HPG46_RS19005	COG0583	DNA-binding transcription factor activity
HPG46_RS19010	COG0517	IMP dehydrogenase activity
HPG46_RS19020	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HPG46_RS19030	COG4703	Protein of unknown function (DUF1797)
HPG46_RS19045	COG2200	EAL domain
HPG46_RS19050	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS19055	COG1408	metallophosphoesterase
HPG46_RS19065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPG46_RS19100	COG2814	Major facilitator Superfamily
HPG46_RS19120	COG3209	COG3209 Rhs family protein
HPG46_RS19130	COG2205	protein histidine kinase activity
HPG46_RS19140	COG0436	Aminotransferase
HPG46_RS19145	COG1609	Transcriptional regulator
HPG46_RS19150	COG3833	ABC-type maltose transport systems, permease component
HPG46_RS19155	COG1175	transmembrane transport
HPG46_RS19160	COG2182	Extracellular solute-binding protein
HPG46_RS19170	COG0366	Alpha amylase catalytic
HPG46_RS19175	COG3842	ATPase activity
HPG46_RS19215	COG0183	Belongs to the thiolase family
HPG46_RS19250	COG1695	Transcriptional regulator
HPG46_RS19255	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS19265	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HPG46_RS19275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPG46_RS19280	COG0436	Aminotransferase
HPG46_RS19315	COG2084	Dehydrogenase
HPG46_RS19320	COG3706	GGDEF domain
HPG46_RS19325	COG0778	Nitroreductase
HPG46_RS19350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS19350	COG2190	(PTS) system
HPG46_RS19350	COG1263	PTS System
HPG46_RS19355	COG3711	transcriptional antiterminator
HPG46_RS19365	COG2188	Transcriptional regulator
HPG46_RS19375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPG46_RS19400	COG1547	Domain of unknown function (DUF309)
HPG46_RS19405	COG0456	acetyltransferase
HPG46_RS19410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPG46_RS19415	COG4086	secreted protein
HPG46_RS19420	COG0561	phosphatase activity
HPG46_RS19425	COG0697	spore germination
HPG46_RS19440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS19465	COG0733	neurotransmitter:sodium symporter activity
HPG46_RS19485	COG1686	Belongs to the peptidase S11 family
HPG46_RS19490	COG1725	Transcriptional regulator
HPG46_RS19495	COG1131	(ABC) transporter
HPG46_RS19510	COG1846	Transcriptional regulator
HPG46_RS19525	COG0598	Magnesium transport protein CorA
HPG46_RS19550	COG4974	Belongs to the 'phage' integrase family
HPG46_RS19560	COG0735	belongs to the Fur family
HPG46_RS19565	COG1300	Membrane
HPG46_RS19585	COG0667	Aldo Keto reductase
HPG46_RS19590	COG0656	L-ascorbic acid biosynthetic process
HPG46_RS19595	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPG46_RS19595	COG0456	acetyltransferase
HPG46_RS19605	COG4085	toxin activity
HPG46_RS19605	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS19605	COG1525	nuclease
HPG46_RS19615	COG0596	Alpha beta hydrolase
HPG46_RS19620	COG2056	Na+-H+ antiporter family
HPG46_RS19625	COG1609	Transcriptional regulator
HPG46_RS19630	COG0456	acetyltransferase
HPG46_RS19635	COG1073	alpha beta
HPG46_RS19650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_RS19650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_RS19655	COG0307	riboflavin synthase, alpha
HPG46_RS19680	COG4106	trans-aconitate 2-methyltransferase activity
HPG46_RS19685	COG2226	methyltransferase
HPG46_RS19685	COG1073	alpha beta
HPG46_RS19700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPG46_RS19715	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS19725	COG1522	sequence-specific DNA binding
HPG46_RS19745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPG46_RS19755	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPG46_RS19770	COG0300	oxidoreductase activity
HPG46_RS19775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS19780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_RS19785	COG1760	l-serine dehydratase
HPG46_RS19790	COG1760	l-serine dehydratase
HPG46_RS19810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPG46_RS19820	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPG46_RS19825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS19840	COG1376	ErfK ybiS ycfS ynhG family protein
HPG46_RS19845	COG4129	membrane
HPG46_RS19850	COG1126	abc transporter atp-binding protein
HPG46_RS19855	COG0765	amino acid transport
HPG46_RS19860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_RS19875	COG2816	NAD+ diphosphatase activity
HPG46_RS19880	COG0772	Belongs to the SEDS family
HPG46_RS19885	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPG46_RS19890	COG0022	dehydrogenase e1 component
HPG46_RS19895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPG46_RS19900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPG46_RS19915	COG0280	phosphate acetyltransferase
HPG46_RS19920	COG3290	protein histidine kinase activity
HPG46_RS19920	COG3829	transcription factor binding
HPG46_RS19930	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_RS19935	COG3093	addiction module antidote protein HigA
HPG46_RS19945	COG0745	RESPONSE REGULATOR receiver
HPG46_RS19950	COG0750	zinc metalloprotease
HPG46_RS19955	COG0497	DNA recombination
HPG46_RS19965	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HPG46_RS19975	COG0142	geranyltranstransferase activity
HPG46_RS20000	COG1302	Protein conserved in bacteria
HPG46_RS20005	COG0439	Biotin carboxylase
HPG46_RS20010	COG0511	ligase activity, forming carbon-carbon bonds
HPG46_RS20055	COG3854	ATPases associated with a variety of cellular activities
HPG46_RS20080	COG0006	proline dipeptidase activity
HPG46_RS20095	COG3872	metal-dependent enzyme
HPG46_RS20105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPG46_RS20135	COG0095	Lipoate-protein ligase
HPG46_RS20140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS20145	COG1609	Transcriptional regulator
HPG46_RS20155	COG2076	Multidrug Resistance protein
HPG46_RS20160	COG2076	Multidrug Resistance protein
HPG46_RS20195	COG1131	(ABC) transporter
HPG46_RS20200	COG1725	Transcriptional regulator
HPG46_RS20230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPG46_RS20285	COG4970	Tfp pilus assembly protein FimT
HPG46_RS20295	COG1459	type II secretion system
HPG46_RS20300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPG46_RS20345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPG46_RS20350	COG1410	methionine synthase
HPG46_RS20350	COG0646	methionine synthase
HPG46_RS20355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPG46_RS20355	COG0646	methionine synthase
HPG46_RS20360	COG0626	cystathionine gamma-synthase activity
HPG46_RS20365	COG0626	cystathionine gamma-synthase activity
HPG46_RS20385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS20395	COG1940	carbohydrate kinase activity
HPG46_RS20400	COG4483	Protein conserved in bacteria
HPG46_RS20405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPG46_RS20410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPG46_RS20415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPG46_RS20420	COG0704	Plays a role in the regulation of phosphate uptake
HPG46_RS20430	COG0581	inorganic phosphate transmembrane transporter activity
HPG46_RS20435	COG0573	inorganic phosphate transmembrane transporter activity
HPG46_RS20440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPG46_RS20450	COG0477	Major facilitator Superfamily
HPG46_RS20455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPG46_RS20480	COG0735	belongs to the Fur family
HPG46_RS20485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPG46_RS20490	COG1121	(ABC) transporter
HPG46_RS20495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS20525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPG46_RS20530	COG2384	SAM-dependent methyltransferase
HPG46_RS20535	COG2010	Cytochrome c
HPG46_RS20540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPG46_RS20545	COG0358	DNA primase activity
HPG46_RS20555	COG0517	IMP dehydrogenase activity
HPG46_RS20570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPG46_RS20575	COG0295	cytidine deaminase activity
HPG46_RS20580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPG46_RS20590	COG1480	7TM receptor with intracellular HD hydrolase
HPG46_RS20595	COG1702	phosphate starvation-inducible protein PhoH
HPG46_RS20610	COG1610	YqeY-like protein
HPG46_RS20615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPG46_RS20620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPG46_RS20625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPG46_RS20655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPG46_RS20660	COG1733	regulation of RNA biosynthetic process
HPG46_RS20685	COG1466	dna polymerase III delta subunit
HPG46_RS20695	COG2333	competence protein COMEC
HPG46_RS20695	COG0658	competence protein
HPG46_RS20700	COG2131	deaminase
HPG46_RS20705	COG1596	polysaccharide export
HPG46_RS20705	COG1555	photosystem II stabilization
HPG46_RS20710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_RS20715	COG2226	methyltransferase
HPG46_RS20720	COG0799	negative regulation of ribosome biogenesis
HPG46_RS20725	COG1713	HD superfamily hydrolase involved in NAD metabolism
HPG46_RS20735	COG1534	Rna-binding protein
HPG46_RS20745	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HPG46_RS20750	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HPG46_RS20775	COG1595	DNA-templated transcription, initiation
HPG46_RS20785	COG0778	Nitroreductase
HPG46_RS20790	COG2357	RelA SpoT domain protein
HPG46_RS20800	COG1785	Belongs to the alkaline phosphatase family
HPG46_RS20810	COG2267	carboxylic ester hydrolase activity
HPG46_RS20845	COG1404	Belongs to the peptidase S8 family
HPG46_RS20850	COG3186	Phenylalanine-4-hydroxylase
HPG46_RS20860	COG2514	catechol 2,3-dioxygenase activity
HPG46_RS20865	COG2259	Doxx family
HPG46_RS20905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS20915	COG1454	alcohol dehydrogenase
HPG46_RS20915	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS20920	COG0626	cystathionine gamma-synthase activity
HPG46_RS20925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPG46_RS20950	COG0768	penicillin binding
HPG46_RS20975	COG4122	O-methyltransferase activity
HPG46_RS20980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPG46_RS21010	COG0628	permease
HPG46_RS21030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPG46_RS21045	COG1104	cysteine desulfurase activity
HPG46_RS21050	COG1959	2 iron, 2 sulfur cluster binding
HPG46_RS21055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPG46_RS21065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPG46_RS21095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPG46_RS21105	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPG46_RS21105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPG46_RS21110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPG46_RS21115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPG46_RS21115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPG46_RS21125	COG2244	polysaccharide biosynthetic process
HPG46_RS21130	COG2323	membrane
HPG46_RS21140	COG1862	Preprotein translocase
HPG46_RS21170	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HPG46_RS21180	COG0697	spore germination
HPG46_RS21185	COG0640	Transcriptional regulator
HPG46_RS21210	COG0157	Belongs to the NadC ModD family
HPG46_RS21215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPG46_RS21220	COG1104	cysteine desulfurase activity
HPG46_RS21225	COG1827	regulation of RNA biosynthetic process
HPG46_RS21230	COG2258	MOSC domain
HPG46_RS21235	COG0077	Prephenate dehydratase
HPG46_RS21240	COG0577	efflux transmembrane transporter activity
HPG46_RS21245	COG0577	efflux transmembrane transporter activity
HPG46_RS21250	COG1136	(ABC) transporter
HPG46_RS21255	COG5002	protein histidine kinase activity
HPG46_RS21260	COG0745	RESPONSE REGULATOR receiver
HPG46_RS21270	COG3290	protein histidine kinase activity
HPG46_RS21280	COG2868	ribosomal protein
HPG46_RS21290	COG1530	ribonuclease E activity
HPG46_RS21295	COG1994	Peptidase M50
HPG46_RS21300	COG0739	heme binding
HPG46_RS21305	COG2894	cell division
HPG46_RS21325	COG1077	Cell shape determining protein MreB Mrl
HPG46_RS21345	COG0285	dihydrofolate synthase activity
HPG46_RS21350	COG0525	valine-tRNA ligase activity
HPG46_RS21360	COG1388	LysM domain
HPG46_RS21370	COG0113	porphobilinogen synthase activity
HPG46_RS21375	COG1587	Uroporphyrinogen-III synthase
HPG46_RS21385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPG46_RS21395	COG1846	Transcriptional regulator
HPG46_RS21400	COG1764	response to oxidative stress
HPG46_RS21415	COG0470	DNA polymerase III
HPG46_RS21415	COG1067	ATP-dependent peptidase activity
HPG46_RS21465	COG0622	Phosphoesterase
HPG46_RS21480	COG5401	PFAM Sporulation and spore germination
HPG46_RS21500	COG1309	transcriptional regulator
HPG46_RS21515	COG2197	response regulator
HPG46_RS21520	COG2233	PERMEase
HPG46_RS21530	COG0402	S-adenosylhomocysteine deaminase activity
HPG46_RS21535	COG0402	S-adenosylhomocysteine deaminase activity
HPG46_RS21555	COG0444	Belongs to the ABC transporter superfamily
HPG46_RS21560	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS21565	COG3275	phosphorelay sensor kinase activity
HPG46_RS21570	COG3279	Response regulator of the LytR AlgR family
HPG46_RS21580	COG1983	PspC domain protein
HPG46_RS21585	COG1396	sequence-specific DNA binding
HPG46_RS21590	COG0697	spore germination
HPG46_RS21600	COG1959	2 iron, 2 sulfur cluster binding
HPG46_RS21605	COG1668	transmembrane transport
HPG46_RS21610	COG4152	abc transporter atp-binding protein
HPG46_RS21615	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HPG46_RS21620	COG1360	Flagellar Motor Protein
HPG46_RS21625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPG46_RS21630	COG1876	peptidase activity
HPG46_RS21635	COG0824	Thioesterase
HPG46_RS21640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPG46_RS21645	COG1053	succinate dehydrogenase
HPG46_RS21650	COG2009	succinate dehydrogenase
HPG46_RS21655	COG1719	4-vinyl reductase, 4VR
HPG46_RS21665	COG3118	belongs to the thioredoxin family
HPG46_RS21670	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPG46_RS21675	COG2086	electron transfer activity
HPG46_RS21680	COG1024	Enoyl-CoA hydratase
HPG46_RS21685	COG1309	transcriptional regulator
HPG46_RS21690	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS21710	COG2318	DinB family
HPG46_RS21730	COG1131	(ABC) transporter
HPG46_RS21735	COG2205	protein histidine kinase activity
HPG46_RS21740	COG0745	RESPONSE REGULATOR receiver
HPG46_RS21750	COG4895	conserved protein (DUF2196)
HPG46_RS21755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPG46_RS21770	COG4509	Sortase family
HPG46_RS21775	COG1120	ATPase activity
HPG46_RS21790	COG5386	Cell surface protein
HPG46_RS21795	COG5386	Cell surface protein
HPG46_RS21800	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS21805	COG1187	pseudouridine synthase activity
HPG46_RS21815	COG1796	DNA polymerase
HPG46_RS21815	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPG46_RS21820	COG1286	toxin biosynthetic process
HPG46_RS21865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPG46_RS21875	COG1418	mRNA catabolic process
HPG46_RS21885	COG2814	Major facilitator Superfamily
HPG46_RS21890	COG1566	PFAM secretion protein HlyD family protein
HPG46_RS21895	COG1309	transcriptional regulator
HPG46_RS21900	COG1363	Peptidase, m42
HPG46_RS21925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPG46_RS21935	COG1484	DNA-dependent DNA replication
HPG46_RS21940	COG3611	Membrane attachment protein
HPG46_RS21950	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPG46_RS21955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPG46_RS21960	COG0237	dephospho-CoA kinase activity
HPG46_RS21965	COG1971	Probably functions as a manganese efflux pump
HPG46_RS21975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPG46_RS21975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPG46_RS21980	COG5002	protein histidine kinase activity
HPG46_RS21985	COG0745	RESPONSE REGULATOR receiver
HPG46_RS22005	COG0538	isocitrate dehydrogenase activity
HPG46_RS22010	COG0372	Belongs to the citrate synthase family
HPG46_RS22020	COG0628	permease
HPG46_RS22025	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPG46_RS22050	COG1725	Transcriptional regulator
HPG46_RS22055	COG0281	malic enzyme
HPG46_RS22060	COG0587	DNA-directed DNA polymerase activity
HPG46_RS22075	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPG46_RS22095	COG4109	DRTGG domain
HPG46_RS22110	COG0006	proline dipeptidase activity
HPG46_RS22150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS22155	COG0662	Cupin 2, conserved barrel domain protein
HPG46_RS22165	COG1476	TRANSCRIPTIONal
HPG46_RS22180	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS22185	COG0589	response to stress
HPG46_RS22225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS22245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPG46_RS22250	COG0827	DNA restriction-modification system
HPG46_RS22255	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPG46_RS22260	COG3874	Sporulation protein YtfJ
HPG46_RS22275	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPG46_RS22285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPG46_RS22300	COG1104	cysteine desulfurase activity
HPG46_RS22310	COG0583	DNA-binding transcription factor activity
HPG46_RS22315	COG0697	spore germination
HPG46_RS22320	COG1309	transcriptional regulator
HPG46_RS22325	COG1956	GAF domain-containing protein
HPG46_RS22330	COG0626	cystathionine gamma-synthase activity
HPG46_RS22385	COG1595	DNA-templated transcription, initiation
HPG46_RS22395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPG46_RS22400	COG0454	-acetyltransferase
HPG46_RS22405	COG0517	IMP dehydrogenase activity
HPG46_RS22410	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPG46_RS22425	COG0745	RESPONSE REGULATOR receiver
HPG46_RS22430	COG5002	protein histidine kinase activity
HPG46_RS22435	COG0666	response to abiotic stimulus
HPG46_RS22470	COG1609	Transcriptional regulator
HPG46_RS22475	COG4851	CamS sex pheromone cAM373 precursor
HPG46_RS22480	COG3118	belongs to the thioredoxin family
HPG46_RS22490	COG2309	aminopeptidase activity
HPG46_RS22510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS22515	COG1695	Transcriptional regulator
HPG46_RS22535	COG1674	ftsk spoiiie
HPG46_RS22545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_RS22555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_RS22560	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HPG46_RS22565	COG1363	Peptidase, m42
HPG46_RS22575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS22590	COG0510	thiamine kinase activity
HPG46_RS22595	COG1523	belongs to the glycosyl hydrolase 13 family
HPG46_RS22605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPG46_RS22610	COG1349	DNA-binding transcription factor activity
HPG46_RS22615	COG1187	pseudouridine synthase activity
HPG46_RS22620	COG2244	polysaccharide biosynthetic process
HPG46_RS22625	COG2081	HI0933 family
HPG46_RS22630	COG2814	Major facilitator Superfamily
HPG46_RS22640	COG3832	glyoxalase III activity
HPG46_RS22660	COG1329	Transcriptional regulator
HPG46_RS22685	COG0314	molybdopterin synthase activity
HPG46_RS22690	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPG46_RS22695	COG0303	'Molybdopterin
HPG46_RS22705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_RS22710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPG46_RS22730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS22740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPG46_RS22780	COG2814	Major facilitator Superfamily
HPG46_RS22785	COG0475	glutathione-regulated potassium exporter activity
HPG46_RS22790	COG0490	domain, Protein
HPG46_RS22795	COG0582	viral genome integration into host DNA
HPG46_RS22805	COG1136	(ABC) transporter
HPG46_RS22825	COG1242	4 iron, 4 sulfur cluster binding
HPG46_RS22830	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HPG46_RS22845	COG1794	racemase activity, acting on amino acids and derivatives
HPG46_RS22855	COG5504	Zn-dependent protease
HPG46_RS22880	COG2267	carboxylic ester hydrolase activity
HPG46_RS22885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPG46_RS22890	COG0671	phosphoesterase, PA-phosphatase related
HPG46_RS22895	COG0438	transferase activity, transferring glycosyl groups
HPG46_RS22905	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPG46_RS22960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPG46_RS22965	COG5002	protein histidine kinase activity
HPG46_RS22970	COG4191	Histidine kinase
HPG46_RS22975	COG2267	carboxylic ester hydrolase activity
HPG46_RS22980	COG1368	sulfuric ester hydrolase activity
HPG46_RS22995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPG46_RS23000	COG1116	anion transmembrane transporter activity
HPG46_RS23005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_RS23020	COG0546	phosphoglycolate phosphatase activity
HPG46_RS23030	COG0494	nUDIX hydrolase
HPG46_RS23060	COG0288	reversible hydration of carbon dioxide
HPG46_RS23065	COG1271	oxidase subunit
HPG46_RS23070	COG1294	oxidase, subunit
HPG46_RS23090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS23115	COG1842	Phage shock protein A
HPG46_RS23160	COG5002	protein histidine kinase activity
HPG46_RS23165	COG0745	RESPONSE REGULATOR receiver
HPG46_RS23195	COG1597	lipid kinase activity
HPG46_RS23210	COG0577	efflux transmembrane transporter activity
HPG46_RS23215	COG1136	(ABC) transporter
HPG46_RS23230	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS23240	COG4977	sequence-specific DNA binding
HPG46_RS23250	COG0577	efflux transmembrane transporter activity
HPG46_RS23255	COG1136	(ABC) transporter
HPG46_RS23260	COG3708	Transcriptional regulator
HPG46_RS23260	COG2207	Transcriptional regulator
HPG46_RS23270	COG5658	integral membrane protein
HPG46_RS23280	COG0745	RESPONSE REGULATOR receiver
HPG46_RS23285	COG2205	protein histidine kinase activity
HPG46_RS23290	COG0577	efflux transmembrane transporter activity
HPG46_RS23295	COG0577	efflux transmembrane transporter activity
HPG46_RS23300	COG1136	(ABC) transporter
HPG46_RS23305	COG0577	efflux transmembrane transporter activity
HPG46_RS23320	COG2188	Transcriptional regulator
HPG46_RS23340	COG3964	amidohydrolase
HPG46_RS23360	COG4948	Mandelate Racemase Muconate Lactonizing
HPG46_RS23370	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPG46_RS23375	COG0596	Alpha beta hydrolase
HPG46_RS23380	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPG46_RS23385	COG1169	isochorismate synthase
HPG46_RS23390	COG1575	Belongs to the MenA family. Type 1 subfamily
HPG46_RS23395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPG46_RS23415	COG0058	SHG alpha-glucan phosphorylase activity
HPG46_RS23425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPG46_RS23445	COG1404	Belongs to the peptidase S8 family
HPG46_RS23545	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPG46_RS23580	COG1285	pathogenesis
HPG46_RS23585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPG46_RS23600	COG2155	Conserved Protein
HPG46_RS23605	COG1098	S1 RNA binding domain
HPG46_RS23610	COG0436	Aminotransferase
HPG46_RS23615	COG1522	sequence-specific DNA binding
HPG46_RS23620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPG46_RS23625	COG2267	carboxylic ester hydrolase activity
HPG46_RS23635	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPG46_RS23655	COG5018	Exonuclease
HPG46_RS23660	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPG46_RS23680	COG2050	protein possibly involved in aromatic compounds catabolism
HPG46_RS23690	COG1268	BioY protein
HPG46_RS23695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPG46_RS23700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPG46_RS23715	COG3584	3D domain protein
HPG46_RS23730	COG1252	NADH dehydrogenase
HPG46_RS23745	COG3708	Transcriptional regulator
HPG46_RS23760	COG1683	Conserved Protein
HPG46_RS23780	COG0316	Belongs to the HesB IscA family
HPG46_RS23795	COG1252	NADH dehydrogenase
HPG46_RS23810	COG0390	transport system, permease component
HPG46_RS23815	COG2824	Alkylphosphonate utilization operon protein PhnA
HPG46_RS23835	COG4837	Protein of unknown function (DUF1462)
HPG46_RS23840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPG46_RS23850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPG46_RS23855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPG46_RS23870	COG1136	(ABC) transporter
HPG46_RS23870	COG0577	efflux transmembrane transporter activity
HPG46_RS23875	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPG46_RS23885	COG0647	UMP catabolic process
HPG46_RS23895	COG2445	Protein of unknown function DUF86
HPG46_RS23900	COG1494	fructose-1,6-bisphosphatase
HPG46_RS23915	COG4470	Protein conserved in bacteria
HPG46_RS23925	COG0789	Transcriptional regulator
HPG46_RS23930	COG4377	Putative membrane peptidase family (DUF2324)
HPG46_RS23955	COG0739	heme binding
HPG46_RS23965	COG3377	Domain of unknown function (DUF1805)
HPG46_RS23970	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS23975	COG1695	Transcriptional regulator
HPG46_RS23985	COG0719	Fe-S assembly protein
HPG46_RS23990	COG0822	iron-sulfur transferase activity
HPG46_RS23995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPG46_RS24000	COG0719	Fe-S assembly protein
HPG46_RS24005	COG0396	ATPase activity
HPG46_RS24010	COG1464	Belongs to the NlpA lipoprotein family
HPG46_RS24015	COG1464	Belongs to the NlpA lipoprotein family
HPG46_RS24020	COG2011	ABC-type metal ion transport system permease component
HPG46_RS24035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_RS24040	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPG46_RS24050	COG1393	Belongs to the ArsC family
HPG46_RS24115	COG1309	transcriptional regulator
HPG46_RS24120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS24125	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS24130	COG0183	Belongs to the thiolase family
HPG46_RS24135	COG1024	Enoyl-CoA hydratase
HPG46_RS24135	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPG46_RS24145	COG1686	Belongs to the peptidase S11 family
HPG46_RS24160	COG0011	TIGRFAM Protein of
HPG46_RS24165	COG0840	transmembrane signaling receptor activity
HPG46_RS24185	COG2814	Major facilitator Superfamily
HPG46_RS24190	COG0531	amino acid
HPG46_RS24200	COG0706	membrane insertase activity
HPG46_RS24210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS24250	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS24260	COG1376	ErfK ybiS ycfS ynhG family protein
HPG46_RS24265	COG0745	RESPONSE REGULATOR receiver
HPG46_RS24270	COG5002	protein histidine kinase activity
HPG46_RS24295	COG0840	transmembrane signaling receptor activity
HPG46_RS24300	COG2151	metal-sulfur cluster biosynthetic enzyme
HPG46_RS24305	COG3227	Zinc metalloprotease (Elastase)
HPG46_RS24310	COG1741	Belongs to the pirin family
HPG46_RS24325	COG0475	glutathione-regulated potassium exporter activity
HPG46_RS24330	COG0490	domain, Protein
HPG46_RS24335	COG1115	amino acid carrier protein
HPG46_RS24340	COG0783	Belongs to the Dps family
HPG46_RS24355	COG1611	Belongs to the LOG family
HPG46_RS24375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS24380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS24385	COG1115	amino acid carrier protein
HPG46_RS24390	COG1115	amino acid carrier protein
HPG46_RS24395	COG2910	NAD(P)H-binding
HPG46_RS24415	COG0656	L-ascorbic acid biosynthetic process
HPG46_RS24420	COG2814	Major facilitator Superfamily
HPG46_RS24425	COG1733	regulation of RNA biosynthetic process
HPG46_RS24435	COG1252	NADH dehydrogenase
HPG46_RS24440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPG46_RS24445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPG46_RS24455	COG3290	protein histidine kinase activity
HPG46_RS24455	COG0840	transmembrane signaling receptor activity
HPG46_RS24485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS24545	COG0557	exoribonuclease II activity
HPG46_RS24550	COG1647	Serine aminopeptidase, S33
HPG46_RS24555	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPG46_RS24560	COG1346	cytolysis
HPG46_RS24595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPG46_RS24610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPG46_RS24630	COG0457	Tetratricopeptide repeat
HPG46_RS24660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS24675	COG2323	membrane
HPG46_RS24685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_RS24695	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPG46_RS24705	COG1051	belongs to the nudix hydrolase family
HPG46_RS24715	COG0492	ferredoxin-NADP+ reductase activity
HPG46_RS24720	COG0457	Tetratricopeptide repeat
HPG46_RS24725	COG0110	maltose O-acetyltransferase activity
HPG46_RS24745	COG1950	PFAM Membrane protein of
HPG46_RS24755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPG46_RS24775	COG0789	Transcriptional regulator
HPG46_RS24805	COG2855	membrane
HPG46_RS24810	COG0583	DNA-binding transcription factor activity
HPG46_RS24820	COG0655	NAD(P)H dehydrogenase (quinone) activity
HPG46_RS24835	COG1132	(ABC) transporter
HPG46_RS24845	COG0583	DNA-binding transcription factor activity
HPG46_RS24850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPG46_RS24855	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_RS24855	COG0793	Belongs to the peptidase S41A family
HPG46_RS24860	COG2177	Part of the ABC transporter FtsEX involved in
HPG46_RS24865	COG2884	Cell division ATP-binding protein ftsE
HPG46_RS24885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPG46_RS24890	COG1278	Cold shock
HPG46_RS24895	COG1040	competence protein
HPG46_RS24900	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HPG46_RS24905	COG1388	LysM domain
HPG46_RS24905	COG0791	NLP P60 protein
HPG46_RS24910	COG1733	regulation of RNA biosynthetic process
HPG46_RS24915	COG1307	EDD domain protein, DegV family
HPG46_RS24920	COG1739	Uncharacterized protein family UPF0029
HPG46_RS24925	COG1316	TRANSCRIPTIONal
HPG46_RS24930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPG46_RS24935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPG46_RS24940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPG46_RS24950	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HPG46_RS24950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPG46_RS24970	COG1486	melibiose metabolic process
HPG46_RS24975	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_RS24980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_RS24990	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPG46_RS25000	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_RS25010	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_RS25015	COG1301	dicarboxylic acid transport
HPG46_RS25025	COG0346	lactoylglutathione lyase activity
HPG46_RS25030	COG1511	domain protein
HPG46_RS25035	COG0583	DNA-binding transcription factor activity
HPG46_RS25040	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HPG46_RS25050	COG1271	oxidase subunit
HPG46_RS25055	COG1294	oxidase, subunit
HPG46_RS25060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPG46_RS25090	COG1620	l-lactate permease
HPG46_RS25100	COG2389	metal-binding protein
HPG46_RS25110	COG1368	sulfuric ester hydrolase activity
HPG46_RS25120	COG0791	NLP P60 protein
HPG46_RS25120	COG1388	LysM domain
HPG46_RS25125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS25135	COG1215	transferase activity, transferring glycosyl groups
HPG46_RS25140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPG46_RS25145	COG3584	3D domain protein
HPG46_RS25145	COG1388	LysM domain
HPG46_RS25170	COG4715	Zinc finger, swim domain protein
HPG46_RS25175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPG46_RS25215	COG0577	efflux transmembrane transporter activity
HPG46_RS25220	COG1136	(ABC) transporter
HPG46_RS25240	COG2271	Major facilitator Superfamily
HPG46_RS25255	COG5002	protein histidine kinase activity
HPG46_RS25260	COG0745	RESPONSE REGULATOR receiver
HPG46_RS25265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPG46_RS25290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPG46_RS25295	COG1134	teichoic acid transport
HPG46_RS25300	COG1682	transport, permease protein
HPG46_RS25305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPG46_RS25325	COG1442	glycosyl transferase family 8
HPG46_RS25325	COG1216	Glycosyl transferase, family 2
HPG46_RS25345	COG1609	Transcriptional regulator
HPG46_RS25350	COG0726	polysaccharide deacetylase
HPG46_RS25360	COG0739	heme binding
HPG46_RS25375	COG3279	Response regulator of the LytR AlgR family
HPG46_RS25380	COG2385	sporulation resulting in formation of a cellular spore
HPG46_RS25395	COG4836	Membrane
HPG46_RS25400	COG1007	ATP synthesis coupled electron transport
HPG46_RS25405	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPG46_RS25410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPG46_RS25420	COG0839	Belongs to the complex I subunit 6 family
HPG46_RS25435	COG0649	NAD binding
HPG46_RS25440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPG46_RS25455	COG5001	Diguanylate cyclase
HPG46_RS25455	COG3300	MHYT domain
HPG46_RS25505	COG0356	it plays a direct role in the translocation of protons across the membrane
HPG46_RS25540	COG0698	ribose 5-phosphate isomerase
HPG46_RS25550	COG2190	(PTS) system
HPG46_RS25555	COG2259	Doxx family
HPG46_RS25560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPG46_RS25575	COG0009	L-threonylcarbamoyladenylate synthase
HPG46_RS25590	COG2890	protein-(glutamine-N5) methyltransferase activity
HPG46_RS25610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPG46_RS25615	COG1494	fructose-1,6-bisphosphatase
HPG46_RS25635	COG4821	SIS domain
HPG46_RS25655	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS25660	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS25665	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPG46_RS25670	COG0183	Belongs to the thiolase family
HPG46_RS25675	COG2181	nitrate reductase activity
HPG46_RS25675	COG0247	lactate metabolic process
HPG46_RS25680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_RS25690	COG3300	MHYT domain
HPG46_RS25690	COG5001	Diguanylate cyclase
HPG46_RS25710	COG2197	response regulator
HPG46_RS25715	COG4585	Histidine kinase
HPG46_RS25720	COG0842	Transport permease protein
HPG46_RS25725	COG1131	(ABC) transporter
HPG46_RS25730	COG0024	Methionine aminopeptidase
HPG46_RS25740	COG2234	aminopeptidase activity
HPG46_RS25760	COG1595	DNA-templated transcription, initiation
HPG46_RS25770	COG4506	Protein conserved in bacteria
HPG46_RS25775	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_RS25790	COG0010	Belongs to the arginase family
HPG46_RS25800	COG2814	Major facilitator Superfamily
HPG46_RS25805	COG0789	Transcriptional regulator
HPG46_RS25810	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_RS25815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_RS25825	COG1994	Peptidase M50
HPG46_RS25835	COG1078	dGTPase activity
HPG46_RS25840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS25845	COG1120	ATPase activity
HPG46_RS25850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS25855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS25875	COG0095	Lipoate-protein ligase
HPG46_RS25880	COG0280	phosphate acetyltransferase
HPG46_RS25895	COG3773	Cell wall hydrolase
HPG46_RS25905	COG2363	Small membrane protein
HPG46_RS25915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPG46_RS25920	COG2233	PERMEase
HPG46_RS25925	COG0561	phosphatase activity
HPG46_RS25930	COG2814	Major facilitator Superfamily
HPG46_RS25940	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPG46_RS25945	COG1131	(ABC) transporter
HPG46_RS25950	COG2755	lipolytic protein G-D-S-L family
HPG46_RS25955	COG1609	Transcriptional regulator
HPG46_RS25965	COG0460	homoserine dehydrogenase
HPG46_RS25975	COG2873	o-acetylhomoserine
HPG46_RS25985	COG1011	Hydrolase
HPG46_RS25990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPG46_RS26000	COG2197	response regulator
HPG46_RS26005	COG2203	Gaf domain
HPG46_RS26005	COG4585	Histidine kinase
HPG46_RS26010	COG0351	phosphomethylpyrimidine kinase
HPG46_RS26015	COG3706	GGDEF domain
HPG46_RS26020	COG2879	small protein
HPG46_RS26025	COG1966	Carbon starvation protein
HPG46_RS26030	COG3279	Response regulator of the LytR AlgR family
HPG46_RS26035	COG0477	Major facilitator Superfamily
HPG46_RS26060	COG0840	transmembrane signaling receptor activity
HPG46_RS26070	COG1607	acyl-coa hydrolase
HPG46_RS26085	COG0488	(ABC) transporter
HPG46_RS26105	COG0463	Glycosyl transferase, family 2
HPG46_RS26110	COG1309	transcriptional regulator
HPG46_RS26115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPG46_RS26120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPG46_RS26120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPG46_RS26125	COG0628	permease
HPG46_RS26140	COG3279	Response regulator of the LytR AlgR family
HPG46_RS26145	COG3275	phosphorelay sensor kinase activity
HPG46_RS26150	COG2814	Major facilitator Superfamily
HPG46_RS26155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPG46_RS26160	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HPG46_RS26165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPG46_RS26185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPG46_RS26190	COG1272	protein, Hemolysin III
HPG46_RS26215	COG1164	Oligoendopeptidase f
HPG46_RS26235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPG46_RS26240	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HPG46_RS26245	COG4853	Protein conserved in bacteria
HPG46_RS26250	COG4863	YycH protein
HPG46_RS26255	COG5002	protein histidine kinase activity
HPG46_RS26260	COG0745	RESPONSE REGULATOR receiver
HPG46_RS26290	COG0305	Participates in initiation and elongation during chromosome replication
HPG46_RS26300	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HPG46_RS26305	COG4241	membrane
HPG46_RS26315	COG0629	single-stranded DNA binding
HPG46_RS26325	COG0012	GTP binding
HPG46_RS26330	COG4481	Protein conserved in bacteria
HPG46_RS26335	COG0668	transmembrane transport
HPG46_RS26345	COG1475	DNA binding
HPG46_RS26350	COG1192	Involved in chromosome partitioning
HPG46_RS26375	COG1847	R3H domain protein
HPG46_RS26380	COG0706	membrane insertase activity
HPG46_RS26390	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPG46_RS26400	COG0592	DNA-directed DNA polymerase activity
HPG46_RS26405	COG2501	S4 domain
HPG46_RS26415	COG0187	DNA topoisomerase II activity
HPG46_RS26420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPG46_RS26455	COG0516	GMP reductase activity
HPG46_RS26455	COG0517	IMP dehydrogenase activity
HPG46_RS26460	COG1686	Belongs to the peptidase S11 family
HPG46_RS26490	COG1428	Deoxynucleoside kinase
HPG46_RS26495	COG1428	Deoxynucleoside kinase
HPG46_RS26500	COG1335	isochorismatase
HPG46_RS26505	COG0590	tRNA wobble adenosine to inosine editing
HPG46_RS26515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPG46_RS26570	COG1982	Orn Lys Arg decarboxylase major
HPG46_RS26580	COG0470	DNA polymerase III
HPG46_RS26585	COG1774	PSP1 C-terminal conserved region
HPG46_RS26595	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPG46_RS26605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPG46_RS26610	COG2002	toxin-antitoxin pair type II binding
HPG46_RS26615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_RS26615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_RS26620	COG0084	hydrolase, TatD family'
HPG46_RS26625	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPG46_RS26640	COG4466	Protein conserved in bacteria
HPG46_RS26655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPG46_RS26660	COG0251	oxidation-reduction process
HPG46_RS26690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPG46_RS26695	COG2002	toxin-antitoxin pair type II binding
HPG46_RS26700	COG2244	polysaccharide biosynthetic process
HPG46_RS26705	COG3956	TIGRFAM MazG family protein
HPG46_RS26710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPG46_RS26730	COG1098	S1 RNA binding domain
HPG46_RS26745	COG2208	phosphoserine phosphatase activity
HPG46_RS26760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPG46_RS26775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPG46_RS26780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPG46_RS26785	COG0512	Glutamine amidotransferase of anthranilate synthase
HPG46_RS26790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_RS26795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPG46_RS26800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPG46_RS26805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPG46_RS26810	COG1396	sequence-specific DNA binding
HPG46_RS26815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPG46_RS26855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS26890	COG2312	Erythromycin esterase
HPG46_RS26900	COG1396	sequence-specific DNA binding
HPG46_RS26920	COG0840	transmembrane signaling receptor activity
HPG46_RS26940	COG5183	chlorophyll binding
HPG46_RS26940	COG2133	pyrroloquinoline quinone binding
HPG46_RS26965	COG2184	nucleotidyltransferase activity
HPG46_RS26970	COG1760	l-serine dehydratase
HPG46_RS26975	COG1760	l-serine dehydratase
HPG46_RS26980	COG0814	amino acid
HPG46_RS26995	COG1309	transcriptional regulator
HPG46_RS27000	COG2814	Major facilitator Superfamily
HPG46_RS27005	COG2184	nucleotidyltransferase activity
HPG46_RS27015	COG0534	Mate efflux family protein
HPG46_RS27030	COG0531	amino acid
HPG46_RS27055	COG2304	oxidoreductase activity
HPG46_RS27065	COG1404	Belongs to the peptidase S8 family
HPG46_RS27080	COG4974	Belongs to the 'phage' integrase family
HPG46_RS27090	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HPG46_RS27095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPG46_RS27100	COG2017	converts alpha-aldose to the beta-anomer
HPG46_RS27110	COG2207	Transcriptional regulator
HPG46_RS27115	COG1266	CAAX protease self-immunity
HPG46_RS27125	COG5492	domain, Protein
HPG46_RS27135	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HPG46_RS27140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_RS27140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS27145	COG3716	PTS system mannose fructose sorbose family IID component
HPG46_RS27150	COG3715	PTS system
HPG46_RS27160	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS27165	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HPG46_RS27170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPG46_RS27180	COG1414	Transcriptional regulator
HPG46_RS27190	COG0457	Tetratricopeptide repeat
HPG46_RS27235	COG0546	phosphoglycolate phosphatase activity
HPG46_RS27240	COG1475	DNA binding
HPG46_RS27245	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS27270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPG46_RS27295	COG2211	Major facilitator Superfamily
HPG46_RS27320	COG2205	protein histidine kinase activity
HPG46_RS27325	COG0745	RESPONSE REGULATOR receiver
HPG46_RS27355	COG2814	Major facilitator Superfamily
HPG46_RS27385	COG3443	Belongs to the bacterial solute-binding protein 9 family
HPG46_RS27395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS27400	COG1923	regulation of RNA biosynthetic process
HPG46_RS27475	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPG46_RS27490	COG1404	Belongs to the peptidase S8 family
HPG46_RS27545	COG0667	Aldo Keto reductase
HPG46_RS27560	COG1396	sequence-specific DNA binding
HPG46_RS27565	COG0582	viral genome integration into host DNA
HPG46_RS27670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPG46_RS27825	COG1404	Belongs to the peptidase S8 family
HPG46_RS27830	COG2197	response regulator
HPG46_RS27835	COG4585	Histidine kinase
HPG46_RS27905	COG1196	nuclear chromosome segregation
HPG46_RS27905	COG0739	heme binding
HPG46_RS27905	COG0741	lytic transglycosylase activity
HPG46_RS27945	COG2234	aminopeptidase activity
HPG46_RS28035	COG2373	Large extracellular alpha-helical protein
HPG46_RS28045	COG3397	chitin binding
HPG46_RS28110	COG1404	Belongs to the peptidase S8 family
HPG46_RS28200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPG46_RS28295	COG4962	Type ii secretion system protein e
HPG46_RS28520	COG0739	heme binding
HPG46_RS28525	COG3227	Zinc metalloprotease (Elastase)
HPG46_RS28545	COG1073	alpha beta
HPG46_RS28550	COG2311	Membrane
HPG46_RS28635	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_RS28660	COG2814	Major facilitator Superfamily
HPG46_RS28690	COG0577	efflux transmembrane transporter activity
HPG46_RS28695	COG1136	(ABC) transporter
HPG46_RS28720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_RS28730	COG1309	transcriptional regulator
HPG46_RS28740	COG4221	oxidoreductase activity
HPG46_RS28750	COG2309	aminopeptidase activity
HPG46_RS28765	COG0456	acetyltransferase
HPG46_RS28790	COG1395	domain, Protein
HPG46_RS28800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins