locus-tag	class	description
HPG46_RS00010	COG0592	DNA-directed DNA polymerase activity
HPG46_RS00015	COG2501	S4 domain
HPG46_RS00025	COG0187	DNA topoisomerase II activity
HPG46_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPG46_RS00065	COG0517	IMP dehydrogenase activity
HPG46_RS00065	COG0516	GMP reductase activity
HPG46_RS00070	COG1686	Belongs to the peptidase S11 family
HPG46_RS00100	COG1428	Deoxynucleoside kinase
HPG46_RS00105	COG1428	Deoxynucleoside kinase
HPG46_RS00110	COG1335	isochorismatase
HPG46_RS00115	COG0590	tRNA wobble adenosine to inosine editing
HPG46_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPG46_RS00180	COG1982	Orn Lys Arg decarboxylase major
HPG46_RS00190	COG0470	DNA polymerase III
HPG46_RS00195	COG1774	PSP1 C-terminal conserved region
HPG46_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPG46_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPG46_RS00220	COG2002	toxin-antitoxin pair type II binding
HPG46_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_RS00230	COG0084	hydrolase, TatD family'
HPG46_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPG46_RS00250	COG4466	Protein conserved in bacteria
HPG46_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPG46_RS00270	COG0251	oxidation-reduction process
HPG46_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPG46_RS00305	COG2002	toxin-antitoxin pair type II binding
HPG46_RS00310	COG2244	polysaccharide biosynthetic process
HPG46_RS00315	COG3956	TIGRFAM MazG family protein
HPG46_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPG46_RS00340	COG1098	S1 RNA binding domain
HPG46_RS00355	COG2208	phosphoserine phosphatase activity
HPG46_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HPG46_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPG46_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPG46_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPG46_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
HPG46_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPG46_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPG46_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPG46_RS00420	COG1396	sequence-specific DNA binding
HPG46_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPG46_RS00525	COG3880	PFAM UvrB UvrC protein
HPG46_RS00535	COG0542	response to heat
HPG46_RS00540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPG46_RS00550	COG4956	integral membrane protein (PIN domain superfamily)
HPG46_RS00570	COG1045	serine acetyltransferase
HPG46_RS00585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPG46_RS00590	COG3688	RNA-binding protein containing a PIN domain
HPG46_RS00605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPG46_RS00610	COG0250	Participates in transcription elongation, termination and antitermination
HPG46_RS00615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPG46_RS00635	COG2813	Specifically methylates the guanine in position
HPG46_RS00650	COG1358	cellular component organization or biogenesis
HPG46_RS00720	COG0255	Belongs to the universal ribosomal protein uL29 family
HPG46_RS00780	COG0201	protein transport
HPG46_RS00790	COG0024	Methionine aminopeptidase
HPG46_RS00800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPG46_RS00835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPG46_RS00860	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS00865	COG0489	protein tyrosine kinase activity
HPG46_RS00875	COG2194	sulfuric ester hydrolase activity
HPG46_RS00880	COG0726	polysaccharide deacetylase
HPG46_RS00960	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HPG46_RS00965	COG4856	YbbR-like protein
HPG46_RS00990	COG0596	Alpha beta hydrolase
HPG46_RS01010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPG46_RS01015	COG0823	Involved in the tonB-independent uptake of proteins
HPG46_RS01015	COG1506	peptidase
HPG46_RS01015	COG4946	Tricorn protease homolog
HPG46_RS01035	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS01040	COG2011	ABC-type metal ion transport system permease component
HPG46_RS01045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPG46_RS01050	COG1464	Belongs to the NlpA lipoprotein family
HPG46_RS01055	COG0604	alcohol dehydrogenase
HPG46_RS01065	COG0277	FAD linked oxidase domain protein
HPG46_RS01070	COG2271	Major facilitator Superfamily
HPG46_RS01080	COG2814	Major facilitator Superfamily
HPG46_RS01095	COG0601	transmembrane transport
HPG46_RS01100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_RS01105	COG0444	Belongs to the ABC transporter superfamily
HPG46_RS01110	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS01115	COG4166	transmembrane transport
HPG46_RS01125	COG2207	Transcriptional regulator
HPG46_RS01140	COG4166	transmembrane transport
HPG46_RS01145	COG4166	transmembrane transport
HPG46_RS01150	COG0656	L-ascorbic acid biosynthetic process
HPG46_RS01155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_RS01170	COG4149	molybdate abc transporter
HPG46_RS01175	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPG46_RS01180	COG1910	domain protein
HPG46_RS01195	COG0697	spore germination
HPG46_RS01210	COG0204	Acyl-transferase
HPG46_RS01220	COG1609	Transcriptional regulator
HPG46_RS01230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS01250	COG5298	Protein conserved in bacteria
HPG46_RS01275	COG0488	(ABC) transporter
HPG46_RS01290	COG0747	negative chemotaxis
HPG46_RS01295	COG0601	transmembrane transport
HPG46_RS01300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_RS01305	COG0444	Belongs to the ABC transporter superfamily
HPG46_RS01310	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS01315	COG0561	phosphatase activity
HPG46_RS01345	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HPG46_RS01350	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPG46_RS01360	COG0531	amino acid
HPG46_RS01365	COG2814	Major facilitator Superfamily
HPG46_RS01375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPG46_RS01385	COG4294	response to UV
HPG46_RS01390	COG0705	Rhomboid family
HPG46_RS01390	COG0457	Tetratricopeptide repeat
HPG46_RS01400	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPG46_RS01405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPG46_RS01410	COG0864	Transcriptional regulator
HPG46_RS01415	COG2337	Toxic component of a toxin-antitoxin (TA) module
HPG46_RS01420	COG2183	response to ionizing radiation
HPG46_RS01515	COG0802	atpase or kinase
HPG46_RS01520	COG1214	PFAM Peptidase M22, glycoprotease
HPG46_RS01525	COG0456	acetyltransferase
HPG46_RS01535	COG0488	(ABC) transporter
HPG46_RS01550	COG1266	CAAX protease self-immunity
HPG46_RS01570	COG2252	PERMEase
HPG46_RS01580	COG5002	protein histidine kinase activity
HPG46_RS01605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HPG46_RS01635	COG2226	methyltransferase
HPG46_RS01645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPG46_RS01655	COG1215	transferase activity, transferring glycosyl groups
HPG46_RS01695	COG2205	protein histidine kinase activity
HPG46_RS01700	COG0745	RESPONSE REGULATOR receiver
HPG46_RS01720	COG0697	spore germination
HPG46_RS01745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPG46_RS01750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPG46_RS01755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPG46_RS01765	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPG46_RS01780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPG46_RS01790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPG46_RS01800	COG0151	Belongs to the GarS family
HPG46_RS01825	COG0210	DNA helicase
HPG46_RS01835	COG4851	CamS sex pheromone cAM373 precursor
HPG46_RS01855	COG1335	isochorismatase
HPG46_RS01860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPG46_RS01865	COG2011	ABC-type metal ion transport system permease component
HPG46_RS01870	COG1464	Belongs to the NlpA lipoprotein family
HPG46_RS01885	COG0003	Pfam Anion-transporting ATPase
HPG46_RS01890	COG1846	Transcriptional regulator
HPG46_RS01895	COG4682	membrane
HPG46_RS01915	COG1597	lipid kinase activity
HPG46_RS01920	COG0546	phosphoglycolate phosphatase activity
HPG46_RS01925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPG46_RS01935	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS01940	COG2076	Multidrug Resistance protein
HPG46_RS01945	COG2309	aminopeptidase activity
HPG46_RS01960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS01965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPG46_RS01970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPG46_RS01975	COG5002	protein histidine kinase activity
HPG46_RS01980	COG4807	Protein conserved in bacteria
HPG46_RS02005	COG1757	Na H antiporter
HPG46_RS02010	COG1473	amidohydrolase
HPG46_RS02025	COG0450	alkyl hydroperoxide reductase
HPG46_RS02045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS02050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS02055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS02070	COG0166	Belongs to the GPI family
HPG46_RS02125	COG3541	Predicted nucleotidyltransferase
HPG46_RS02130	COG2814	Major facilitator Superfamily
HPG46_RS02135	COG0723	plastoquinol--plastocyanin reductase activity
HPG46_RS02135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_RS02145	COG0765	amino acid transport
HPG46_RS02150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_RS02160	COG0840	transmembrane signaling receptor activity
HPG46_RS02165	COG0840	transmembrane signaling receptor activity
HPG46_RS02170	COG0366	Alpha amylase catalytic
HPG46_RS02175	COG1263	PTS System
HPG46_RS02175	COG2190	(PTS) system
HPG46_RS02175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS02205	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPG46_RS02220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_RS02230	COG1116	anion transmembrane transporter activity
HPG46_RS02240	COG0488	(ABC) transporter
HPG46_RS02290	COG2270	Major facilitator Superfamily
HPG46_RS02320	COG2310	stress, protein
HPG46_RS02325	COG2310	stress, protein
HPG46_RS02330	COG2310	stress, protein
HPG46_RS02335	COG0861	Integral membrane protein TerC family
HPG46_RS02345	COG3853	Toxic anion resistance protein (TelA)
HPG46_RS02360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPG46_RS02370	COG1295	ribonuclease BN
HPG46_RS02375	COG2217	Heavy metal translocating P-type atpase
HPG46_RS02380	COG0697	spore germination
HPG46_RS02390	COG0681	Belongs to the peptidase S26 family
HPG46_RS02400	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS02415	COG3871	stress protein (general stress protein 26)
HPG46_RS02420	COG0387	Pfam Sodium calcium exchanger
HPG46_RS02430	COG0535	radical SAM domain protein
HPG46_RS02450	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPG46_RS02455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPG46_RS02470	COG3829	transcription factor binding
HPG46_RS02480	COG0833	amino acid
HPG46_RS02485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPG46_RS02515	COG1263	PTS System
HPG46_RS02515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS02520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_RS02540	COG0463	Glycosyl transferase, family 2
HPG46_RS02550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPG46_RS02550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPG46_RS02570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPG46_RS02590	COG1228	amidohydrolase
HPG46_RS02595	COG1090	epimerase
HPG46_RS02625	COG1988	membrane-bound metal-dependent
HPG46_RS02630	COG1194	a g-specific adenine glycosylase
HPG46_RS02655	COG1132	(ABC) transporter
HPG46_RS02660	COG4129	membrane
HPG46_RS02665	COG0069	glutamate synthase activity
HPG46_RS02665	COG0070	glutamate synthase
HPG46_RS02665	COG0067	glutamate synthase
HPG46_RS02675	COG4555	ABC transporter
HPG46_RS02695	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPG46_RS02700	COG0735	belongs to the Fur family
HPG46_RS02815	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPG46_RS02820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPG46_RS02830	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPG46_RS02840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPG46_RS02850	COG2766	serine protein kinase
HPG46_RS02870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPG46_RS02880	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPG46_RS02885	COG2268	Band 7 protein
HPG46_RS02895	COG3290	protein histidine kinase activity
HPG46_RS02900	COG4565	transcriptional regulatory protein
HPG46_RS02905	COG2851	Citrate transporter
HPG46_RS02925	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HPG46_RS02930	COG3842	ATPase activity
HPG46_RS02935	COG1175	transmembrane transport
HPG46_RS02940	COG0395	ABC-type sugar transport system, permease component
HPG46_RS02950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPG46_RS02955	COG0745	RESPONSE REGULATOR receiver
HPG46_RS02960	COG5002	protein histidine kinase activity
HPG46_RS02970	COG4990	cell redox homeostasis
HPG46_RS02980	COG3290	protein histidine kinase activity
HPG46_RS02985	COG4565	transcriptional regulatory protein
HPG46_RS02990	COG3493	citrate carrier protein
HPG46_RS02995	COG0281	malic enzyme
HPG46_RS03010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS03020	COG5002	protein histidine kinase activity
HPG46_RS03025	COG0745	RESPONSE REGULATOR receiver
HPG46_RS03030	COG0454	-acetyltransferase
HPG46_RS03030	COG0456	acetyltransferase
HPG46_RS03035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPG46_RS03040	COG3383	formate dehydrogenase (NAD+) activity
HPG46_RS03045	COG2427	Protein of unknown function (DUF1641)
HPG46_RS03060	COG0531	amino acid
HPG46_RS03065	COG0640	Transcriptional regulator
HPG46_RS03070	COG2217	Heavy metal translocating P-type atpase
HPG46_RS03075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPG46_RS03090	COG3227	Zinc metalloprotease (Elastase)
HPG46_RS03110	COG2720	vancomycin resistance protein
HPG46_RS03115	COG1316	TRANSCRIPTIONal
HPG46_RS03120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS03125	COG0346	lactoylglutathione lyase activity
HPG46_RS03130	COG1253	flavin adenine dinucleotide binding
HPG46_RS03135	COG1027	Aspartate ammonia-lyase
HPG46_RS03140	COG1620	l-lactate permease
HPG46_RS03155	COG3104	oligopeptide transport
HPG46_RS03160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS03165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS03170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS03180	COG2226	methyltransferase
HPG46_RS03185	COG0156	8-amino-7-oxononanoate synthase activity
HPG46_RS03190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPG46_RS03195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPG46_RS03205	COG4548	von Willebrand factor, type A
HPG46_RS03210	COG0714	Associated with various cellular activities
HPG46_RS03215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_RS03235	COG0531	amino acid
HPG46_RS03240	COG2188	Transcriptional regulator
HPG46_RS03245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS03245	COG1263	PTS System
HPG46_RS03250	COG0366	Alpha amylase catalytic
HPG46_RS03265	COG0697	spore germination
HPG46_RS03275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPG46_RS03280	COG1115	amino acid carrier protein
HPG46_RS03285	COG1126	abc transporter atp-binding protein
HPG46_RS03290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_RS03295	COG0765	amino acid transport
HPG46_RS03300	COG0765	amino acid transport
HPG46_RS03305	COG0833	amino acid
HPG46_RS03330	COG2378	regulation of single-species biofilm formation
HPG46_RS03335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPG46_RS03340	COG5002	protein histidine kinase activity
HPG46_RS03355	COG0659	secondary active sulfate transmembrane transporter activity
HPG46_RS03370	COG0747	negative chemotaxis
HPG46_RS03380	COG0601	transmembrane transport
HPG46_RS03385	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS03395	COG2271	Major facilitator Superfamily
HPG46_RS03400	COG1846	Transcriptional regulator
HPG46_RS03405	COG0477	Major facilitator Superfamily
HPG46_RS03410	COG1609	Transcriptional regulator
HPG46_RS03415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPG46_RS03430	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPG46_RS03435	COG1879	ABC-type sugar transport system periplasmic component
HPG46_RS03455	COG1063	alcohol dehydrogenase
HPG46_RS03470	COG3568	Endonuclease Exonuclease Phosphatase
HPG46_RS03500	COG0840	transmembrane signaling receptor activity
HPG46_RS03505	COG3584	3D domain protein
HPG46_RS03505	COG1388	LysM domain
HPG46_RS03510	COG1476	TRANSCRIPTIONal
HPG46_RS03525	COG3104	oligopeptide transport
HPG46_RS03530	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS03535	COG1464	Belongs to the NlpA lipoprotein family
HPG46_RS03540	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS03545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPG46_RS03550	COG2011	ABC-type metal ion transport system permease component
HPG46_RS03565	COG1113	amino acid transport
HPG46_RS03570	COG2252	PERMEase
HPG46_RS03585	COG2153	protein acetylation
HPG46_RS03595	COG0569	domain protein
HPG46_RS03595	COG0475	glutathione-regulated potassium exporter activity
HPG46_RS03610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPG46_RS03615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPG46_RS03620	COG0833	amino acid
HPG46_RS03625	COG4990	cell redox homeostasis
HPG46_RS03640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_RS03645	COG0697	spore germination
HPG46_RS03650	COG0531	amino acid
HPG46_RS03660	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPG46_RS03665	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPG46_RS03670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPG46_RS03670	COG1918	ferrous iron import across plasma membrane
HPG46_RS03675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPG46_RS03680	COG0573	inorganic phosphate transmembrane transporter activity
HPG46_RS03685	COG0581	inorganic phosphate transmembrane transporter activity
HPG46_RS03695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPG46_RS03815	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HPG46_RS03835	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPG46_RS03840	COG1116	anion transmembrane transporter activity
HPG46_RS03845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_RS03850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPG46_RS03855	COG0352	thiamine-phosphate diphosphorylase activity
HPG46_RS03860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_RS03865	COG2104	thiamine diphosphate biosynthetic process
HPG46_RS03875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_RS03880	COG0351	phosphomethylpyrimidine kinase
HPG46_RS03920	COG2205	protein histidine kinase activity
HPG46_RS03925	COG2814	Major facilitator Superfamily
HPG46_RS03930	COG1846	Transcriptional regulator
HPG46_RS03955	COG0577	efflux transmembrane transporter activity
HPG46_RS03955	COG1136	(ABC) transporter
HPG46_RS03965	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPG46_RS03975	COG1879	ABC-type sugar transport system periplasmic component
HPG46_RS03980	COG2252	PERMEase
HPG46_RS03985	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS03990	COG1376	ErfK ybiS ycfS ynhG family protein
HPG46_RS04005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_RS04045	COG0778	Nitroreductase
HPG46_RS04050	COG2719	SpoVR family
HPG46_RS04055	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPG46_RS04060	COG1937	Protein conserved in bacteria
HPG46_RS04065	COG0425	Belongs to the sulfur carrier protein TusA family
HPG46_RS04065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS04070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS04070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS04075	COG0425	Belongs to the sulfur carrier protein TusA family
HPG46_RS04080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS04090	COG2210	Belongs to the sulfur carrier protein TusA family
HPG46_RS04095	COG0730	response to heat
HPG46_RS04105	COG1316	TRANSCRIPTIONal
HPG46_RS04110	COG0604	alcohol dehydrogenase
HPG46_RS04115	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPG46_RS04130	COG3711	transcriptional antiterminator
HPG46_RS04130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_RS04135	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_RS04140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_RS04160	COG3584	3D domain protein
HPG46_RS04160	COG1388	LysM domain
HPG46_RS04165	COG0577	efflux transmembrane transporter activity
HPG46_RS04170	COG1136	(ABC) transporter
HPG46_RS04180	COG5522	Integral membrane protein (intg_mem_TP0381)
HPG46_RS04195	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS04200	COG3546	catalase activity
HPG46_RS04235	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS04270	COG0531	amino acid
HPG46_RS04275	COG0475	glutathione-regulated potassium exporter activity
HPG46_RS04285	COG1737	Transcriptional regulator
HPG46_RS04295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS04295	COG1263	PTS System
HPG46_RS04305	COG2259	Doxx family
HPG46_RS04320	COG0697	spore germination
HPG46_RS04325	COG1522	sequence-specific DNA binding
HPG46_RS04340	COG2076	Multidrug Resistance protein
HPG46_RS04345	COG1309	transcriptional regulator
HPG46_RS04350	COG2814	Major facilitator Superfamily
HPG46_RS04355	COG0657	acetylesterase activity
HPG46_RS04360	COG1309	transcriptional regulator
HPG46_RS04365	COG2124	cytochrome p450
HPG46_RS04375	COG1063	alcohol dehydrogenase
HPG46_RS04380	COG4533	DNA binding
HPG46_RS04385	COG2211	Major facilitator Superfamily
HPG46_RS04395	COG0693	protein deglycase activity
HPG46_RS04400	COG0693	protein deglycase activity
HPG46_RS04400	COG0753	catalase activity
HPG46_RS04410	COG0531	amino acid
HPG46_RS04425	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS04430	COG1132	(ABC) transporter
HPG46_RS04435	COG1132	(ABC) transporter
HPG46_RS04440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_RS04445	COG0765	amino acid transport
HPG46_RS04450	COG1126	abc transporter atp-binding protein
HPG46_RS04465	COG0189	ligase activity
HPG46_RS04495	COG0028	Belongs to the TPP enzyme family
HPG46_RS04500	COG3527	Alpha-acetolactate decarboxylase
HPG46_RS04510	COG0561	phosphatase activity
HPG46_RS04515	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS04515	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_RS04520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPG46_RS04525	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS04535	COG0659	secondary active sulfate transmembrane transporter activity
HPG46_RS04560	COG0653	protein targeting
HPG46_RS04565	COG2244	polysaccharide biosynthetic process
HPG46_RS04575	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS04580	COG4196	transglutaminase domain protein
HPG46_RS04595	COG1696	Membrane protein involved in D-alanine export
HPG46_RS04610	COG1024	Enoyl-CoA hydratase
HPG46_RS04635	COG1363	Peptidase, m42
HPG46_RS04655	COG3938	Belongs to the proline racemase family
HPG46_RS04695	COG0601	transmembrane transport
HPG46_RS04700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_RS04705	COG0444	Belongs to the ABC transporter superfamily
HPG46_RS04710	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS04725	COG0477	Major facilitator Superfamily
HPG46_RS04730	COG3290	protein histidine kinase activity
HPG46_RS04735	COG4565	transcriptional regulatory protein
HPG46_RS04740	COG3181	Tripartite tricarboxylate transporter family receptor
HPG46_RS04785	COG4978	Transcriptional regulator
HPG46_RS04785	COG0789	Transcriptional regulator
HPG46_RS04800	COG0305	Participates in initiation and elongation during chromosome replication
HPG46_RS04840	COG0477	Major facilitator Superfamily
HPG46_RS04885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPG46_RS04885	COG3320	Male sterility
HPG46_RS04890	COG1309	transcriptional regulator
HPG46_RS04905	COG1183	phosphatidylcholine synthase activity
HPG46_RS04925	COG2376	Dihydroxyacetone kinase
HPG46_RS04935	COG2376	Dihydroxyacetone kinase
HPG46_RS04945	COG1959	2 iron, 2 sulfur cluster binding
HPG46_RS05035	COG1136	(ABC) transporter
HPG46_RS05040	COG0577	efflux transmembrane transporter activity
HPG46_RS05095	COG1191	sigma factor activity
HPG46_RS05105	COG2208	phosphoserine phosphatase activity
HPG46_RS05110	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPG46_RS05115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_RS05115	COG2198	Histidine kinase
HPG46_RS05115	COG2205	protein histidine kinase activity
HPG46_RS05115	COG0784	Response regulator, receiver
HPG46_RS05170	COG0420	3'-5' exonuclease activity
HPG46_RS05175	COG4717	serine-type aminopeptidase activity
HPG46_RS05210	COG0346	lactoylglutathione lyase activity
HPG46_RS05215	COG0346	lactoylglutathione lyase activity
HPG46_RS05220	COG0457	Tetratricopeptide repeat
HPG46_RS05230	COG2267	carboxylic ester hydrolase activity
HPG46_RS05250	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HPG46_RS05255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPG46_RS05265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPG46_RS05310	COG0477	Major facilitator Superfamily
HPG46_RS05315	COG0477	Major facilitator Superfamily
HPG46_RS05325	COG3973	AAA domain
HPG46_RS05330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPG46_RS05350	COG4980	gas vesicle protein
HPG46_RS05355	COG0537	adenosine 5'-monophosphoramidase activity
HPG46_RS05360	COG1131	(ABC) transporter
HPG46_RS05365	COG4473	ABC transporter
HPG46_RS05420	COG1309	transcriptional regulator
HPG46_RS05430	COG3402	PFAM membrane-flanked domain
HPG46_RS05435	COG3428	Bacterial PH domain
HPG46_RS05475	COG3402	PFAM membrane-flanked domain
HPG46_RS05480	COG3428	Bacterial PH domain
HPG46_RS05485	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_RS05490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_RS05505	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HPG46_RS05540	COG1309	transcriptional regulator
HPG46_RS05545	COG1511	domain protein
HPG46_RS05570	COG2378	regulation of single-species biofilm formation
HPG46_RS05575	COG1609	Transcriptional regulator
HPG46_RS05585	COG1234	tRNA 3'-trailer cleavage
HPG46_RS05590	COG0095	Lipoate-protein ligase
HPG46_RS05600	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS05620	COG1408	metallophosphoesterase
HPG46_RS05630	COG1078	dGTPase activity
HPG46_RS05640	COG1595	DNA-templated transcription, initiation
HPG46_RS05645	COG2207	Transcriptional regulator
HPG46_RS05645	COG3708	Transcriptional regulator
HPG46_RS05660	COG2205	protein histidine kinase activity
HPG46_RS05665	COG0745	RESPONSE REGULATOR receiver
HPG46_RS05690	COG0501	Belongs to the peptidase M48B family
HPG46_RS05695	COG0840	transmembrane signaling receptor activity
HPG46_RS05700	COG0697	spore germination
HPG46_RS05720	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPG46_RS05725	COG2224	Isocitrate lyase
HPG46_RS05750	COG4903	ComK protein
HPG46_RS05755	COG0398	Pfam SNARE associated Golgi protein
HPG46_RS05815	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPG46_RS05840	COG0367	asparagine synthase
HPG46_RS05845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPG46_RS05850	COG0753	catalase activity
HPG46_RS05855	COG0004	ammonium transporteR
HPG46_RS05875	COG2996	Protein conserved in bacteria
HPG46_RS05885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPG46_RS05895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS05910	COG0561	phosphatase activity
HPG46_RS05920	COG0542	response to heat
HPG46_RS05930	COG2267	carboxylic ester hydrolase activity
HPG46_RS05945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS05950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPG46_RS05955	COG5504	Zn-dependent protease
HPG46_RS05965	COG0180	Tryptophanyl-tRNA synthetase
HPG46_RS05975	COG4166	transmembrane transport
HPG46_RS05980	COG0601	transmembrane transport
HPG46_RS05985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_RS05990	COG0444	Belongs to the ABC transporter superfamily
HPG46_RS05995	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS06000	COG0534	Mate efflux family protein
HPG46_RS06005	COG4166	transmembrane transport
HPG46_RS06020	COG0861	Integral membrane protein TerC family
HPG46_RS06025	COG4862	establishment of competence for transformation
HPG46_RS06030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_RS06040	COG1164	Oligoendopeptidase f
HPG46_RS06055	COG2346	COG2346, Truncated hemoglobins
HPG46_RS06060	COG4116	CYTH
HPG46_RS06070	COG2357	RelA SpoT domain protein
HPG46_RS06080	COG0564	pseudouridine synthase activity
HPG46_RS06095	COG0772	Belongs to the SEDS family
HPG46_RS06100	COG0463	Glycosyl transferase, family 2
HPG46_RS06100	COG1216	Glycosyl transferase, family 2
HPG46_RS06120	COG0463	Glycosyl transferase, family 2
HPG46_RS06120	COG0457	Tetratricopeptide repeat
HPG46_RS06140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPG46_RS06155	COG1091	dTDP-4-dehydrorhamnose reductase activity
HPG46_RS06200	COG2153	protein acetylation
HPG46_RS06210	COG2382	esterase
HPG46_RS06225	COG5492	domain, Protein
HPG46_RS06230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_RS06240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPG46_RS06240	COG0512	Glutamine amidotransferase of anthranilate synthase
HPG46_RS06275	COG1620	l-lactate permease
HPG46_RS06280	COG5634	Uncharacterized conserved protein (DUF2278)
HPG46_RS06335	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPG46_RS06345	COG1476	TRANSCRIPTIONal
HPG46_RS06400	COG2226	methyltransferase
HPG46_RS06410	COG1686	Belongs to the peptidase S11 family
HPG46_RS06415	COG0681	Belongs to the peptidase S26 family
HPG46_RS06450	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS06460	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPG46_RS06465	COG1177	transmembrane transport
HPG46_RS06470	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPG46_RS06480	COG2409	Drug exporters of the RND superfamily
HPG46_RS06490	COG0564	pseudouridine synthase activity
HPG46_RS06500	COG2340	Cysteine-rich secretory protein family
HPG46_RS06505	COG0247	lactate metabolic process
HPG46_RS06510	COG0277	FAD linked oxidase domain protein
HPG46_RS06515	COG3835	regulator
HPG46_RS06525	COG0745	RESPONSE REGULATOR receiver
HPG46_RS06530	COG5002	protein histidine kinase activity
HPG46_RS06535	COG2186	Transcriptional regulator
HPG46_RS06555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HPG46_RS06565	COG2116	formate transmembrane transporter activity
HPG46_RS06570	COG0861	Integral membrane protein TerC family
HPG46_RS06575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPG46_RS06585	COG2030	dehydratase
HPG46_RS06605	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS06610	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPG46_RS06615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_RS06620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPG46_RS06635	COG1840	ABC-type Fe3 transport system, periplasmic component
HPG46_RS06640	COG3842	ATPase activity
HPG46_RS06665	COG1349	DNA-binding transcription factor activity
HPG46_RS06675	COG0235	Class ii aldolase
HPG46_RS06685	COG2861	carbohydrate metabolic process
HPG46_RS06695	COG3852	Histidine kinase
HPG46_RS06700	COG1846	Transcriptional regulator
HPG46_RS06710	COG2318	DinB family
HPG46_RS06715	COG5002	protein histidine kinase activity
HPG46_RS06725	COG0720	synthase
HPG46_RS06740	COG4873	Protein conserved in bacteria
HPG46_RS06770	COG1780	Probably involved in ribonucleotide reductase function
HPG46_RS06790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPG46_RS06795	COG1725	Transcriptional regulator
HPG46_RS06800	COG1131	(ABC) transporter
HPG46_RS06810	COG1131	(ABC) transporter
HPG46_RS06815	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPG46_RS06830	COG1522	sequence-specific DNA binding
HPG46_RS06850	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_RS06855	COG2070	2-Nitropropane dioxygenase
HPG46_RS06860	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HPG46_RS06870	COG1696	Membrane protein involved in D-alanine export
HPG46_RS06895	COG0716	FMN binding
HPG46_RS06910	COG3173	Aminoglycoside phosphotransferase
HPG46_RS06935	COG1968	undecaprenyl-diphosphatase activity
HPG46_RS06950	COG1846	Transcriptional regulator
HPG46_RS06960	COG1301	dicarboxylic acid transport
HPG46_RS06965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPG46_RS06970	COG4709	membrane
HPG46_RS06975	COG3874	Sporulation protein YtfJ
HPG46_RS06995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_RS07000	COG0028	Belongs to the TPP enzyme family
HPG46_RS07005	COG0440	acetolactate synthase activity
HPG46_RS07080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPG46_RS07095	COG1183	phosphatidylcholine synthase activity
HPG46_RS07100	COG1368	sulfuric ester hydrolase activity
HPG46_RS07110	COG0019	diaminopimelate decarboxylase activity
HPG46_RS07130	COG0529	Catalyzes the synthesis of activated sulfate
HPG46_RS07135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPG46_RS07155	COG1648	precorrin-2 dehydrogenase activity
HPG46_RS07160	COG0733	neurotransmitter:sodium symporter activity
HPG46_RS07180	COG1757	Na H antiporter
HPG46_RS07195	COG4758	membrane
HPG46_RS07200	COG4585	Histidine kinase
HPG46_RS07205	COG2197	response regulator
HPG46_RS07215	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS07225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPG46_RS07265	COG0730	response to heat
HPG46_RS07270	COG0306	phosphate transporter
HPG46_RS07275	COG1392	Phosphate transport regulator
HPG46_RS07280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_RS07295	COG3852	Histidine kinase
HPG46_RS07300	COG1801	Protein of unknown function DUF72
HPG46_RS07310	COG0582	viral genome integration into host DNA
HPG46_RS07315	COG5002	protein histidine kinase activity
HPG46_RS07330	COG0392	lysyltransferase activity
HPG46_RS07330	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HPG46_RS07345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPG46_RS07350	COG1686	Belongs to the peptidase S11 family
HPG46_RS07355	COG2715	membrane protein required for spore maturation
HPG46_RS07360	COG0700	Nucleoside recognition
HPG46_RS07365	COG1187	pseudouridine synthase activity
HPG46_RS07375	COG1333	cytochrome c biogenesis protein
HPG46_RS07380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPG46_RS07385	COG0745	RESPONSE REGULATOR receiver
HPG46_RS07390	COG5002	protein histidine kinase activity
HPG46_RS07395	COG2096	Adenosyltransferase
HPG46_RS07400	COG4942	peptidase
HPG46_RS07410	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HPG46_RS07415	COG1141	Ferredoxin
HPG46_RS07425	COG0514	ATP-dependent DNA helicase (RecQ)
HPG46_RS07430	COG1266	CAAX protease self-immunity
HPG46_RS07440	COG1408	metallophosphoesterase
HPG46_RS07450	COG4862	establishment of competence for transformation
HPG46_RS07455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPG46_RS07475	COG0492	ferredoxin-NADP+ reductase activity
HPG46_RS07550	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPG46_RS07565	COG0142	geranyltranstransferase activity
HPG46_RS07575	COG0142	geranyltranstransferase activity
HPG46_RS07595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPG46_RS07600	COG0457	Tetratricopeptide repeat
HPG46_RS07620	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPG46_RS07630	COG4347	Protein of unknown function (DUF1405)
HPG46_RS07645	COG2738	Putative neutral zinc metallopeptidase
HPG46_RS07655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS07660	COG1694	Mazg nucleotide pyrophosphohydrolase
HPG46_RS07675	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPG46_RS07680	COG0438	transferase activity, transferring glycosyl groups
HPG46_RS07715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPG46_RS07715	COG1199	ATP-dependent helicase activity
HPG46_RS07735	COG3935	DnaD domain protein
HPG46_RS07740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPG46_RS07750	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPG46_RS07750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_RS07810	COG0116	Belongs to the methyltransferase superfamily
HPG46_RS07820	COG1199	ATP-dependent helicase activity
HPG46_RS07825	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPG46_RS07835	COG3173	Aminoglycoside phosphotransferase
HPG46_RS07840	COG0024	Methionine aminopeptidase
HPG46_RS07850	COG2233	PERMEase
HPG46_RS07855	COG2311	Membrane
HPG46_RS07860	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPG46_RS07870	COG0456	acetyltransferase
HPG46_RS07905	COG0754	glutathionylspermidine amidase activity
HPG46_RS07920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPG46_RS07945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPG46_RS07960	COG1215	transferase activity, transferring glycosyl groups
HPG46_RS07965	COG0438	transferase activity, transferring glycosyl groups
HPG46_RS07980	COG0454	-acetyltransferase
HPG46_RS08000	COG0328	RNA-DNA hybrid ribonuclease activity
HPG46_RS08035	COG3403	YqcI/YcgG family
HPG46_RS08040	COG1280	lysine exporter protein (LysE YggA)
HPG46_RS08055	COG3162	membrane
HPG46_RS08060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_RS08065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPG46_RS08075	COG0475	glutathione-regulated potassium exporter activity
HPG46_RS08080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPG46_RS08085	COG0789	Transcriptional regulator
HPG46_RS08085	COG4978	Transcriptional regulator
HPG46_RS08095	COG2323	membrane
HPG46_RS08100	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPG46_RS08155	COG1923	regulation of RNA biosynthetic process
HPG46_RS08165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPG46_RS08170	COG1360	Flagellar Motor Protein
HPG46_RS08175	COG2201	protein-glutamate methylesterase activity
HPG46_RS08180	COG0643	Histidine kinase
HPG46_RS08180	COG2198	Histidine kinase
HPG46_RS08185	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_RS08185	COG1776	CheC inhibitor of MCP methylation
HPG46_RS08200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPG46_RS08220	COG1256	bacterial-type flagellum assembly
HPG46_RS08225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPG46_RS08230	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPG46_RS08245	COG1815	bacterial-type flagellum-dependent cell motility
HPG46_RS08250	COG1558	bacterial-type flagellum-dependent cell motility
HPG46_RS08260	COG1766	The M ring may be actively involved in energy transduction
HPG46_RS08265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_RS08275	COG1157	protein secretion by the type III secretion system
HPG46_RS08310	COG0784	Response regulator, receiver
HPG46_RS08310	COG0835	chemotaxis
HPG46_RS08335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPG46_RS08340	COG0741	lytic transglycosylase activity
HPG46_RS08350	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_RS08355	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPG46_RS08355	COG1776	CheC inhibitor of MCP methylation
HPG46_RS08365	COG1338	Plays a role in the flagellum-specific transport system
HPG46_RS08370	COG1987	bacterial-type flagellum assembly
HPG46_RS08380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPG46_RS08385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPG46_RS08390	COG1419	protein localization to endoplasmic reticulum
HPG46_RS08395	COG4786	Flagellar basal body rod
HPG46_RS08400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPG46_RS08445	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_RS08470	COG0583	DNA-binding transcription factor activity
HPG46_RS08475	COG3842	ATPase activity
HPG46_RS08480	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPG46_RS08490	COG1234	tRNA 3'-trailer cleavage
HPG46_RS08540	COG0406	alpha-ribazole phosphatase activity
HPG46_RS08570	COG0367	asparagine synthase
HPG46_RS08600	COG1802	Transcriptional regulator
HPG46_RS08605	COG0697	spore germination
HPG46_RS08610	COG0523	cobalamin synthesis protein
HPG46_RS08615	COG0701	Predicted permease
HPG46_RS08625	COG1216	Glycosyl transferase, family 2
HPG46_RS08625	COG0438	transferase activity, transferring glycosyl groups
HPG46_RS08630	COG1757	Na H antiporter
HPG46_RS08635	COG0114	fumarate hydratase activity
HPG46_RS08650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS08660	COG0534	Mate efflux family protein
HPG46_RS08665	COG3340	Belongs to the peptidase S51 family
HPG46_RS08685	COG0785	Cytochrome C biogenesis protein
HPG46_RS08715	COG2733	membrane
HPG46_RS08750	COG1131	(ABC) transporter
HPG46_RS08765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_RS08770	COG0528	UMP kinase activity
HPG46_RS08780	COG1027	Aspartate ammonia-lyase
HPG46_RS08785	COG0281	malic enzyme
HPG46_RS08790	COG4191	Histidine kinase
HPG46_RS08795	COG0784	Response regulator, receiver
HPG46_RS08800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPG46_RS08820	COG3620	sequence-specific DNA binding
HPG46_RS08845	COG1051	belongs to the nudix hydrolase family
HPG46_RS08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS08860	COG2814	Major facilitator Superfamily
HPG46_RS08885	COG1695	Transcriptional regulator
HPG46_RS08895	COG0477	Major facilitator Superfamily
HPG46_RS08900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS08910	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPG46_RS08915	COG4166	transmembrane transport
HPG46_RS08920	COG2223	nitrite transmembrane transporter activity
HPG46_RS08925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPG46_RS08940	COG2244	polysaccharide biosynthetic process
HPG46_RS08945	COG0733	neurotransmitter:sodium symporter activity
HPG46_RS08955	COG5566	PFAM Mor transcription activator
HPG46_RS08960	COG2323	membrane
HPG46_RS08975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPG46_RS08985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_RS08990	COG0028	Belongs to the TPP enzyme family
HPG46_RS08995	COG0440	acetolactate synthase activity
HPG46_RS09000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPG46_RS09010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPG46_RS09035	COG2814	Major facilitator Superfamily
HPG46_RS09040	COG3384	dioxygenase
HPG46_RS09050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPG46_RS09055	COG3279	Response regulator of the LytR AlgR family
HPG46_RS09060	COG0427	acetyl-CoA hydrolase
HPG46_RS09080	COG1073	alpha beta
HPG46_RS09085	COG4166	transmembrane transport
HPG46_RS09120	COG0535	radical SAM domain protein
HPG46_RS09125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS09145	COG1914	H( )-stimulated, divalent metal cation uptake system
HPG46_RS09160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPG46_RS09165	COG0531	amino acid
HPG46_RS09190	COG2390	Transcriptional regulator
HPG46_RS09200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS09205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPG46_RS09240	COG0006	proline dipeptidase activity
HPG46_RS09245	COG2132	Multicopper oxidase
HPG46_RS09260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPG46_RS09280	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS09290	COG1276	copper resistance
HPG46_RS09290	COG2372	response to copper ion
HPG46_RS09295	COG4549	nuclear export factor GLE1
HPG46_RS09305	COG0697	spore germination
HPG46_RS09310	COG0583	DNA-binding transcription factor activity
HPG46_RS09315	COG1959	2 iron, 2 sulfur cluster binding
HPG46_RS09320	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HPG46_RS09325	COG0778	Nitroreductase
HPG46_RS09340	COG0628	permease
HPG46_RS09350	COG1231	oxidoreductase activity
HPG46_RS09355	COG0523	cobalamin synthesis protein
HPG46_RS09370	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS09375	COG2030	dehydratase
HPG46_RS09380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS09390	COG0411	ABC transporter
HPG46_RS09410	COG0583	DNA-binding transcription factor activity
HPG46_RS09420	COG1942	4-Oxalocrotonate Tautomerase
HPG46_RS09440	COG1271	oxidase subunit
HPG46_RS09445	COG1294	oxidase, subunit
HPG46_RS09450	COG4988	ABC transporter
HPG46_RS09455	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPG46_RS09470	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_RS09475	COG1686	Belongs to the peptidase S11 family
HPG46_RS09490	COG1388	LysM domain
HPG46_RS09490	COG0791	NLP P60 protein
HPG46_RS09500	COG1132	(ABC) transporter
HPG46_RS09505	COG0745	RESPONSE REGULATOR receiver
HPG46_RS09510	COG5002	protein histidine kinase activity
HPG46_RS09515	COG0300	oxidoreductase activity
HPG46_RS09520	COG4122	O-methyltransferase activity
HPG46_RS09535	COG5658	integral membrane protein
HPG46_RS09550	COG0460	homoserine dehydrogenase
HPG46_RS09575	COG1316	TRANSCRIPTIONal
HPG46_RS09585	COG0745	RESPONSE REGULATOR receiver
HPG46_RS09590	COG5002	protein histidine kinase activity
HPG46_RS09605	COG1285	pathogenesis
HPG46_RS09610	COG1247	-acetyltransferase
HPG46_RS09630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPG46_RS09640	COG1082	Xylose isomerase domain protein TIM barrel
HPG46_RS09650	COG2814	Major facilitator Superfamily
HPG46_RS09655	COG1279	arginine transmembrane transporter activity
HPG46_RS09665	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPG46_RS09700	COG0577	efflux transmembrane transporter activity
HPG46_RS09705	COG2002	toxin-antitoxin pair type II binding
HPG46_RS09710	COG1404	Belongs to the peptidase S8 family
HPG46_RS09715	COG0640	Transcriptional regulator
HPG46_RS09720	COG0667	Aldo Keto reductase
HPG46_RS09725	COG2814	Major facilitator Superfamily
HPG46_RS09750	COG0840	transmembrane signaling receptor activity
HPG46_RS09765	COG3949	Membrane
HPG46_RS09770	COG0783	Belongs to the Dps family
HPG46_RS09785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPG46_RS09795	COG1231	oxidoreductase activity
HPG46_RS09805	COG4989	oxidoreductase activity
HPG46_RS09810	COG0523	cobalamin synthesis protein
HPG46_RS09815	COG0456	acetyltransferase
HPG46_RS09835	COG3443	Belongs to the bacterial solute-binding protein 9 family
HPG46_RS09835	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPG46_RS09845	COG0702	epimerase
HPG46_RS09855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPG46_RS09865	COG4166	transmembrane transport
HPG46_RS09880	COG0406	alpha-ribazole phosphatase activity
HPG46_RS09890	COG5337	Spore coat protein CotH
HPG46_RS09895	COG1051	belongs to the nudix hydrolase family
HPG46_RS09900	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS09905	COG2244	polysaccharide biosynthetic process
HPG46_RS09915	COG0701	Predicted permease
HPG46_RS09920	COG3689	TIGRFAM TIGR03943 family protein
HPG46_RS09925	COG1607	acyl-coa hydrolase
HPG46_RS09935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_RS09950	COG0702	epimerase
HPG46_RS09955	COG2839	Protein conserved in bacteria
HPG46_RS09960	COG1253	flavin adenine dinucleotide binding
HPG46_RS09975	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS09980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_RS10000	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS10010	COG1876	peptidase activity
HPG46_RS10020	COG0154	amidase activity
HPG46_RS10025	COG2211	Major facilitator Superfamily
HPG46_RS10040	COG2368	4-hydroxyphenylacetate
HPG46_RS10050	COG0196	riboflavin kinase activity
HPG46_RS10065	COG0251	oxidation-reduction process
HPG46_RS10075	COG3971	2-oxopent-4-enoate hydratase activity
HPG46_RS10095	COG1942	4-Oxalocrotonate Tautomerase
HPG46_RS10105	COG0561	phosphatase activity
HPG46_RS10115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPG46_RS10120	COG4106	trans-aconitate 2-methyltransferase activity
HPG46_RS10135	COG1819	glycosyl
HPG46_RS10140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS10145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS10175	COG0456	acetyltransferase
HPG46_RS10200	COG3874	Sporulation protein YtfJ
HPG46_RS10225	COG2226	methyltransferase
HPG46_RS10245	COG1082	Xylose isomerase domain protein TIM barrel
HPG46_RS10250	COG0346	lactoylglutathione lyase activity
HPG46_RS10260	COG0604	alcohol dehydrogenase
HPG46_RS10265	COG1595	DNA-templated transcription, initiation
HPG46_RS10280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPG46_RS10300	COG0386	Belongs to the glutathione peroxidase family
HPG46_RS10305	COG1305	Transglutaminase-like
HPG46_RS10310	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HPG46_RS10315	COG0714	Associated with various cellular activities
HPG46_RS10330	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPG46_RS10335	COG1140	nitrate reductase beta subunit
HPG46_RS10340	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPG46_RS10345	COG2181	nitrate reductase activity
HPG46_RS10350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPG46_RS10355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPG46_RS10360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_RS10365	COG0303	'Molybdopterin
HPG46_RS10370	COG0314	molybdopterin synthase activity
HPG46_RS10380	COG2223	nitrite transmembrane transporter activity
HPG46_RS10395	COG1648	precorrin-2 dehydrogenase activity
HPG46_RS10405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPG46_RS10405	COG1587	Uroporphyrinogen-III synthase
HPG46_RS10410	COG2146	nitrite reductase [NAD(P)H] activity
HPG46_RS10415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPG46_RS10420	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HPG46_RS10445	COG2359	stage V sporulation protein S
HPG46_RS10480	COG1418	mRNA catabolic process
HPG46_RS10485	COG0488	(ABC) transporter
HPG46_RS10500	COG0629	single-stranded DNA binding
HPG46_RS10505	COG1413	lyase activity
HPG46_RS10520	COG2136	Putative SAM-dependent methyltransferase
HPG46_RS10520	COG2521	methyltransferase
HPG46_RS10550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPG46_RS10570	COG0017	Asparaginyl-tRNA synthetase
HPG46_RS10590	COG1674	ftsk spoiiie
HPG46_RS10700	COG1929	Belongs to the glycerate kinase type-1 family
HPG46_RS10705	COG0471	metal ion transport
HPG46_RS10710	COG0745	RESPONSE REGULATOR receiver
HPG46_RS10715	COG5002	protein histidine kinase activity
HPG46_RS10715	COG3850	Histidine kinase
HPG46_RS10730	COG0733	neurotransmitter:sodium symporter activity
HPG46_RS10755	COG2610	gluconate transmembrane transporter activity
HPG46_RS10760	COG1454	alcohol dehydrogenase
HPG46_RS10765	COG1794	racemase activity, acting on amino acids and derivatives
HPG46_RS10775	COG0456	acetyltransferase
HPG46_RS10780	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPG46_RS10790	COG1131	(ABC) transporter
HPG46_RS10795	COG4473	ABC transporter
HPG46_RS10805	COG0546	phosphoglycolate phosphatase activity
HPG46_RS10825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_RS10830	COG3250	beta-galactosidase activity
HPG46_RS10845	COG0768	penicillin binding
HPG46_RS10855	COG0204	Acyl-transferase
HPG46_RS10860	COG1272	protein, Hemolysin III
HPG46_RS10870	COG0805	protein transport
HPG46_RS10880	COG1307	EDD domain protein, DegV family
HPG46_RS10885	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HPG46_RS10890	COG1999	signal sequence binding
HPG46_RS10895	COG0071	Belongs to the small heat shock protein (HSP20) family
HPG46_RS10900	COG0367	asparagine synthase
HPG46_RS10915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS10920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPG46_RS10940	COG1335	isochorismatase
HPG46_RS10945	COG1051	belongs to the nudix hydrolase family
HPG46_RS10950	COG0071	Belongs to the small heat shock protein (HSP20) family
HPG46_RS10955	COG0668	transmembrane transport
HPG46_RS10960	COG4585	Histidine kinase
HPG46_RS10960	COG2203	Gaf domain
HPG46_RS10965	COG2197	response regulator
HPG46_RS10975	COG1064	alcohol dehydrogenase
HPG46_RS11000	COG1070	Carbohydrate kinase
HPG46_RS11005	COG1070	Carbohydrate kinase
HPG46_RS11035	COG0517	IMP dehydrogenase activity
HPG46_RS11035	COG1125	glycine betaine transport
HPG46_RS11040	COG1174	glycine betaine transport
HPG46_RS11075	COG1253	flavin adenine dinucleotide binding
HPG46_RS11080	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS11085	COG5506	Protein of unknown function (DUF1694)
HPG46_RS11100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPG46_RS11105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPG46_RS11110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPG46_RS11115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPG46_RS11120	COG0456	acetyltransferase
HPG46_RS11125	COG3829	transcription factor binding
HPG46_RS11130	COG1509	lysine 2,3-aminomutase activity
HPG46_RS11170	COG4326	sporulation control protein
HPG46_RS11175	COG0671	phosphoesterase, PA-phosphatase related
HPG46_RS11180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPG46_RS11185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_RS11245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPG46_RS11275	COG0300	oxidoreductase activity
HPG46_RS11295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_RS11295	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPG46_RS11300	COG2814	Major facilitator Superfamily
HPG46_RS11305	COG4841	protein insertion into membrane
HPG46_RS11310	COG0372	Belongs to the citrate synthase family
HPG46_RS11315	COG2079	MmgE PrpD family protein
HPG46_RS11320	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPG46_RS11325	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS11330	COG2084	Dehydrogenase
HPG46_RS11340	COG1280	lysine exporter protein (LysE YggA)
HPG46_RS11345	COG1024	Enoyl-CoA hydratase
HPG46_RS11360	COG0420	3'-5' exonuclease activity
HPG46_RS11365	COG0419	ATPase involved in DNA repair
HPG46_RS11380	COG2223	nitrite transmembrane transporter activity
HPG46_RS11385	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS11390	COG1169	isochorismate synthase
HPG46_RS11395	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPG46_RS11400	COG3433	isochorismatase activity
HPG46_RS11400	COG1535	isochorismatase
HPG46_RS11405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPG46_RS11410	COG3251	PFAM MbtH domain protein
HPG46_RS11415	COG2814	Major facilitator Superfamily
HPG46_RS11430	COG0776	regulation of translation
HPG46_RS11440	COG2318	DinB family
HPG46_RS11450	COG1115	amino acid carrier protein
HPG46_RS11465	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_RS11470	COG1187	pseudouridine synthase activity
HPG46_RS11475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPG46_RS11480	COG1136	(ABC) transporter
HPG46_RS11490	COG0596	Alpha beta hydrolase
HPG46_RS11495	COG2814	Major facilitator Superfamily
HPG46_RS11515	COG2226	methyltransferase
HPG46_RS11545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPG46_RS11560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS11595	COG1247	-acetyltransferase
HPG46_RS11625	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HPG46_RS11635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS11645	COG1278	Cold shock
HPG46_RS11660	COG0010	Belongs to the arginase family
HPG46_RS11665	COG0561	phosphatase activity
HPG46_RS11715	COG0583	DNA-binding transcription factor activity
HPG46_RS11720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPG46_RS11735	COG0583	DNA-binding transcription factor activity
HPG46_RS11740	COG2258	MOSC domain
HPG46_RS11755	COG1132	(ABC) transporter
HPG46_RS11760	COG1132	(ABC) transporter
HPG46_RS11780	COG1396	sequence-specific DNA binding
HPG46_RS11810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPG46_RS11820	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPG46_RS11825	COG1595	DNA-templated transcription, initiation
HPG46_RS11850	COG1649	PFAM Uncharacterised BCR, COG1649
HPG46_RS11875	COG2971	BadF BadG BcrA BcrD
HPG46_RS11885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPG46_RS11910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS11940	COG1309	transcriptional regulator
HPG46_RS11955	COG1136	(ABC) transporter
HPG46_RS11955	COG0577	efflux transmembrane transporter activity
HPG46_RS11960	COG0500	methyltransferase
HPG46_RS11960	COG3615	Tellurite resistance protein tehB
HPG46_RS11975	COG3961	Belongs to the TPP enzyme family
HPG46_RS11980	COG1846	Transcriptional regulator
HPG46_RS12020	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPG46_RS12035	COG1595	DNA-templated transcription, initiation
HPG46_RS12045	COG0768	penicillin binding
HPG46_RS12050	COG0768	penicillin binding
HPG46_RS12055	COG2367	Beta-lactamase
HPG46_RS12060	COG0671	phosphoesterase, PA-phosphatase related
HPG46_RS12065	COG1609	Transcriptional regulator
HPG46_RS12070	COG2814	Major facilitator Superfamily
HPG46_RS12075	COG0673	inositol 2-dehydrogenase activity
HPG46_RS12100	COG0191	fructose-bisphosphate aldolase activity
HPG46_RS12105	COG3718	enzyme involved in inositol metabolism
HPG46_RS12115	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS12125	COG0457	Tetratricopeptide repeat
HPG46_RS12140	COG1876	peptidase activity
HPG46_RS12160	COG1309	transcriptional regulator
HPG46_RS12165	COG0488	(ABC) transporter
HPG46_RS12200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS12235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS12265	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS12270	COG0439	Biotin carboxylase
HPG46_RS12275	COG0511	ligase activity, forming carbon-carbon bonds
HPG46_RS12280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPG46_RS12285	COG1024	Enoyl-CoA hydratase
HPG46_RS12290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPG46_RS12295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPG46_RS12305	COG1247	-acetyltransferase
HPG46_RS12310	COG0572	uridine kinase
HPG46_RS12320	COG1686	Belongs to the peptidase S11 family
HPG46_RS12345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPG46_RS12365	COG3227	Zinc metalloprotease (Elastase)
HPG46_RS12385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPG46_RS12410	COG2814	Major facilitator Superfamily
HPG46_RS12450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS12470	COG1063	alcohol dehydrogenase
HPG46_RS12490	COG3386	PFAM SMP-30 Gluconolaconase
HPG46_RS12500	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HPG46_RS12505	COG3773	Cell wall hydrolase
HPG46_RS12515	COG0745	RESPONSE REGULATOR receiver
HPG46_RS12520	COG2205	protein histidine kinase activity
HPG46_RS12530	COG0488	(ABC) transporter
HPG46_RS12545	COG1136	(ABC) transporter
HPG46_RS12550	COG0577	efflux transmembrane transporter activity
HPG46_RS12570	COG0460	homoserine dehydrogenase
HPG46_RS12575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS12585	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPG46_RS12610	COG0582	viral genome integration into host DNA
HPG46_RS12625	COG1396	sequence-specific DNA binding
HPG46_RS12655	COG1484	DNA-dependent DNA replication
HPG46_RS12740	COG0582	viral genome integration into host DNA
HPG46_RS12925	COG2124	cytochrome p450
HPG46_RS12960	COG0561	phosphatase activity
HPG46_RS12965	COG5002	protein histidine kinase activity
HPG46_RS12970	COG0768	penicillin binding
HPG46_RS12975	COG1819	glycosyl
HPG46_RS12980	COG1794	racemase activity, acting on amino acids and derivatives
HPG46_RS12990	COG1122	ATPase activity
HPG46_RS13005	COG2205	protein histidine kinase activity
HPG46_RS13015	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPG46_RS13020	COG0604	alcohol dehydrogenase
HPG46_RS13025	COG0671	phosphoesterase, PA-phosphatase related
HPG46_RS13030	COG0768	penicillin binding
HPG46_RS13040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_RS13095	COG2814	Major facilitator Superfamily
HPG46_RS13110	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_RS13125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS13130	COG0697	spore germination
HPG46_RS13160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_RS13170	COG2223	nitrite transmembrane transporter activity
HPG46_RS13185	COG2816	NAD+ diphosphatase activity
HPG46_RS13190	COG0592	DNA-directed DNA polymerase activity
HPG46_RS13195	COG1051	belongs to the nudix hydrolase family
HPG46_RS13225	COG3878	Protein conserved in bacteria
HPG46_RS13245	COG4667	esterase of the alpha-beta hydrolase superfamily
HPG46_RS13270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPG46_RS13285	COG0322	excinuclease ABC activity
HPG46_RS13325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_RS13350	COG1011	Hydrolase
HPG46_RS13370	COG1523	belongs to the glycosyl hydrolase 13 family
HPG46_RS13375	COG3227	Zinc metalloprotease (Elastase)
HPG46_RS13395	COG0201	protein transport
HPG46_RS13405	COG0697	spore germination
HPG46_RS13410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS13450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS13465	COG2959	enzyme of heme biosynthesis
HPG46_RS13490	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HPG46_RS13495	COG3844	kynureninase activity
HPG46_RS13500	COG1309	transcriptional regulator
HPG46_RS13530	COG3284	Transcriptional regulator
HPG46_RS13550	COG1349	DNA-binding transcription factor activity
HPG46_RS13570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPG46_RS13575	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPG46_RS13580	COG0022	dehydrogenase e1 component
HPG46_RS13585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPG46_RS13595	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS13600	COG0456	acetyltransferase
HPG46_RS13600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPG46_RS13610	COG0494	nUDIX hydrolase
HPG46_RS13635	COG4176	ABC-type proline glycine betaine transport system permease component
HPG46_RS13640	COG0517	IMP dehydrogenase activity
HPG46_RS13640	COG4175	Glycine betaine
HPG46_RS13670	COG2153	protein acetylation
HPG46_RS13675	COG3397	chitin binding
HPG46_RS13690	COG2205	protein histidine kinase activity
HPG46_RS13695	COG2226	methyltransferase
HPG46_RS13710	COG2333	competence protein COMEC
HPG46_RS13710	COG0658	competence protein
HPG46_RS13760	COG3973	AAA domain
HPG46_RS13775	COG2105	PFAM AIG2 family protein
HPG46_RS13780	COG0514	ATP-dependent DNA helicase (RecQ)
HPG46_RS13810	COG4637	Psort location Cytoplasmic, score
HPG46_RS13830	COG3397	chitin binding
HPG46_RS13845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPG46_RS13850	COG1115	amino acid carrier protein
HPG46_RS13855	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS13860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPG46_RS13870	COG3938	Belongs to the proline racemase family
HPG46_RS13875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_RS13925	COG1078	dGTPase activity
HPG46_RS13930	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS13945	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HPG46_RS13950	COG0519	Catalyzes the synthesis of GMP from XMP
HPG46_RS13955	COG4166	transmembrane transport
HPG46_RS13965	COG4948	Mandelate Racemase Muconate Lactonizing
HPG46_RS14005	COG2936	dipeptidyl-peptidase activity
HPG46_RS14010	COG5002	protein histidine kinase activity
HPG46_RS14015	COG0745	RESPONSE REGULATOR receiver
HPG46_RS14050	COG1164	Oligoendopeptidase f
HPG46_RS14065	COG1307	EDD domain protein, DegV family
HPG46_RS14100	COG2814	Major facilitator Superfamily
HPG46_RS14110	COG1664	Polymer-forming cytoskeletal
HPG46_RS14115	COG0789	Transcriptional regulator
HPG46_RS14120	COG4533	DNA binding
HPG46_RS14125	COG0477	Major facilitator Superfamily
HPG46_RS14125	COG2814	Major facilitator Superfamily
HPG46_RS14145	COG2261	transglycosylase associated protein
HPG46_RS14160	COG2226	methyltransferase
HPG46_RS14195	COG0436	Aminotransferase
HPG46_RS14200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPG46_RS14205	COG5146	pantothenate kinase activity
HPG46_RS14210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HPG46_RS14270	COG0628	permease
HPG46_RS14280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPG46_RS14285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_RS14290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPG46_RS14295	COG1116	anion transmembrane transporter activity
HPG46_RS14315	COG2816	NAD+ diphosphatase activity
HPG46_RS14335	COG2746	aminoglycoside 3-N-acetyltransferase activity
HPG46_RS14360	COG0697	spore germination
HPG46_RS14365	COG2318	DinB family
HPG46_RS14385	COG4912	Dna alkylation repair
HPG46_RS14405	COG0861	Integral membrane protein TerC family
HPG46_RS14410	COG1368	sulfuric ester hydrolase activity
HPG46_RS14415	COG0488	(ABC) transporter
HPG46_RS14425	COG1033	growth of symbiont in host cell
HPG46_RS14425	COG2409	Drug exporters of the RND superfamily
HPG46_RS14430	COG1309	transcriptional regulator
HPG46_RS14445	COG0287	Prephenate dehydrogenase
HPG46_RS14450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPG46_RS14460	COG1605	Chorismate mutase
HPG46_RS14460	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HPG46_RS14495	COG1388	LysM domain
HPG46_RS14495	COG3584	3D domain protein
HPG46_RS14505	COG1595	DNA-templated transcription, initiation
HPG46_RS14530	COG1879	ABC-type sugar transport system periplasmic component
HPG46_RS14540	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPG46_RS14550	COG2390	Transcriptional regulator
HPG46_RS14555	COG1070	Carbohydrate kinase
HPG46_RS14585	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_RS14605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS14615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPG46_RS14620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_RS14625	COG4187	Peptidase family M20/M25/M40
HPG46_RS14630	COG1414	Transcriptional regulator
HPG46_RS14635	COG0833	amino acid
HPG46_RS14645	COG3239	Fatty acid desaturase
HPG46_RS14650	COG1785	Belongs to the alkaline phosphatase family
HPG46_RS14660	COG3655	Transcriptional regulator
HPG46_RS14675	COG4377	Putative membrane peptidase family (DUF2324)
HPG46_RS14685	COG3279	Response regulator of the LytR AlgR family
HPG46_RS14695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS14700	COG0346	lactoylglutathione lyase activity
HPG46_RS14720	COG0714	Associated with various cellular activities
HPG46_RS14745	COG0463	Glycosyl transferase, family 2
HPG46_RS14760	COG0463	Glycosyl transferase, family 2
HPG46_RS14770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPG46_RS14775	COG0753	catalase activity
HPG46_RS14785	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HPG46_RS14810	COG0714	Associated with various cellular activities
HPG46_RS14820	COG0778	Nitroreductase
HPG46_RS14825	COG1846	Transcriptional regulator
HPG46_RS14845	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPG46_RS14865	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS14870	COG0183	Belongs to the thiolase family
HPG46_RS14875	COG1024	Enoyl-CoA hydratase
HPG46_RS14880	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPG46_RS14885	COG2723	6-phospho-beta-galactosidase activity
HPG46_RS14890	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_RS14895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_RS14910	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_RS14920	COG2508	Transcriptional regulator
HPG46_RS14925	COG2814	Major facilitator Superfamily
HPG46_RS14930	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPG46_RS14960	COG1725	Transcriptional regulator
HPG46_RS14970	COG1136	(ABC) transporter
HPG46_RS14995	COG2207	Transcriptional regulator
HPG46_RS15000	COG0456	acetyltransferase
HPG46_RS15020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS15070	COG0730	response to heat
HPG46_RS15080	COG0833	amino acid
HPG46_RS15090	COG4335	DNA alkylation repair
HPG46_RS15120	COG0768	penicillin binding
HPG46_RS15150	COG1984	allophanate hydrolase subunit 2
HPG46_RS15155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPG46_RS15160	COG1414	Transcriptional regulator
HPG46_RS15180	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS15185	COG0640	Transcriptional regulator
HPG46_RS15195	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS15210	COG3314	Sporulation integral membrane protein YlbJ
HPG46_RS15240	COG3848	Pyruvate phosphate dikinase
HPG46_RS15240	COG0574	Belongs to the PEP-utilizing enzyme family
HPG46_RS15245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS15260	COG5577	PFAM Coat F domain
HPG46_RS15265	COG3403	YqcI/YcgG family
HPG46_RS15270	COG1280	lysine exporter protein (LysE YggA)
HPG46_RS15275	COG1113	amino acid transport
HPG46_RS15305	COG1063	alcohol dehydrogenase
HPG46_RS15315	COG1027	Aspartate ammonia-lyase
HPG46_RS15320	COG0252	asparaginase activity
HPG46_RS15325	COG1396	sequence-specific DNA binding
HPG46_RS15340	COG0531	amino acid
HPG46_RS15345	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS15350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_RS15370	COG0784	Response regulator, receiver
HPG46_RS15375	COG4191	Histidine kinase
HPG46_RS15380	COG2066	Belongs to the glutaminase family
HPG46_RS15385	COG1115	amino acid carrier protein
HPG46_RS15425	COG0723	plastoquinol--plastocyanin reductase activity
HPG46_RS15425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPG46_RS15430	COG0534	Mate efflux family protein
HPG46_RS15440	COG0531	amino acid
HPG46_RS15445	COG1525	nuclease
HPG46_RS15445	COG4085	toxin activity
HPG46_RS15445	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS15450	COG0753	catalase activity
HPG46_RS15455	COG2267	carboxylic ester hydrolase activity
HPG46_RS15460	COG1335	isochorismatase
HPG46_RS15480	COG0583	DNA-binding transcription factor activity
HPG46_RS15485	COG1846	Transcriptional regulator
HPG46_RS15490	COG0598	Magnesium transport protein CorA
HPG46_RS15525	COG0415	Belongs to the DNA photolyase family
HPG46_RS15530	COG0288	reversible hydration of carbon dioxide
HPG46_RS15540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPG46_RS15545	COG5609	conserved protein (DUF2294)
HPG46_RS15560	COG0714	Associated with various cellular activities
HPG46_RS15570	COG1575	Belongs to the MenA family. Type 1 subfamily
HPG46_RS15595	COG4641	Protein conserved in bacteria
HPG46_RS15625	COG0798	PFAM Bile acid sodium symporter
HPG46_RS15630	COG0346	lactoylglutathione lyase activity
HPG46_RS15635	COG0640	Transcriptional regulator
HPG46_RS15655	COG5002	protein histidine kinase activity
HPG46_RS15660	COG0745	RESPONSE REGULATOR receiver
HPG46_RS15665	COG0456	acetyltransferase
HPG46_RS15680	COG1309	transcriptional regulator
HPG46_RS15685	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS15705	COG0346	lactoylglutathione lyase activity
HPG46_RS15725	COG2169	Transcriptional regulator
HPG46_RS15770	COG2814	Major facilitator Superfamily
HPG46_RS15795	COG0745	RESPONSE REGULATOR receiver
HPG46_RS15800	COG3850	Histidine kinase
HPG46_RS15800	COG5002	protein histidine kinase activity
HPG46_RS15825	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HPG46_RS15850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS15855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPG46_RS15865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS15870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HPG46_RS15890	COG0577	efflux transmembrane transporter activity
HPG46_RS15905	COG5002	protein histidine kinase activity
HPG46_RS15905	COG3850	Histidine kinase
HPG46_RS15915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS15920	COG2271	Major facilitator Superfamily
HPG46_RS15925	COG1556	Lactate utilization protein
HPG46_RS15930	COG1139	Iron-sulfur cluster binding protein
HPG46_RS15940	COG0583	DNA-binding transcription factor activity
HPG46_RS15960	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_RS15975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPG46_RS15995	COG1595	DNA-templated transcription, initiation
HPG46_RS16010	COG0662	Cupin 2, conserved barrel domain protein
HPG46_RS16015	COG2207	Transcriptional regulator
HPG46_RS16015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS16030	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS16030	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_RS16070	COG0477	Major facilitator Superfamily
HPG46_RS16080	COG1846	Transcriptional regulator
HPG46_RS16085	COG2814	Major facilitator Superfamily
HPG46_RS16095	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPG46_RS16100	COG1131	(ABC) transporter
HPG46_RS16120	COG2076	Multidrug Resistance protein
HPG46_RS16125	COG1309	transcriptional regulator
HPG46_RS16140	COG2031	fatty acid transporter
HPG46_RS16150	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPG46_RS16180	COG1122	ATPase activity
HPG46_RS16185	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPG46_RS16200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPG46_RS16205	COG1288	antiporter activity
HPG46_RS16210	COG2356	endonuclease I
HPG46_RS16225	COG3620	sequence-specific DNA binding
HPG46_RS16235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPG46_RS16255	COG1733	regulation of RNA biosynthetic process
HPG46_RS16260	COG0778	Nitroreductase
HPG46_RS16280	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS16290	COG1131	(ABC) transporter
HPG46_RS16315	COG1011	Hydrolase
HPG46_RS16325	COG2365	Tyrosine phosphatase family
HPG46_RS16350	COG0346	lactoylglutathione lyase activity
HPG46_RS16355	COG1940	carbohydrate kinase activity
HPG46_RS16360	COG0738	Major facilitator superfamily
HPG46_RS16365	COG0110	maltose O-acetyltransferase activity
HPG46_RS16380	COG0628	permease
HPG46_RS16400	COG2226	methyltransferase
HPG46_RS16410	COG0477	Major facilitator Superfamily
HPG46_RS16440	COG1253	flavin adenine dinucleotide binding
HPG46_RS16445	COG0789	Transcriptional regulator
HPG46_RS16455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPG46_RS16485	COG0697	spore germination
HPG46_RS16490	COG1357	PFAM Pentapeptide repeats (8 copies)
HPG46_RS16495	COG3813	Protein conserved in bacteria
HPG46_RS16500	COG2706	6-phosphogluconolactonase activity
HPG46_RS16505	COG1070	Carbohydrate kinase
HPG46_RS16515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPG46_RS16520	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HPG46_RS16530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPG46_RS16535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPG46_RS16540	COG0604	alcohol dehydrogenase
HPG46_RS16545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPG46_RS16555	COG0604	alcohol dehydrogenase
HPG46_RS16555	COG3321	synthase
HPG46_RS16560	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS16580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_RS16580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_RS16585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPG46_RS16585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPG46_RS16590	COG1733	regulation of RNA biosynthetic process
HPG46_RS16605	COG0656	L-ascorbic acid biosynthetic process
HPG46_RS16610	COG2814	Major facilitator Superfamily
HPG46_RS16625	COG0346	lactoylglutathione lyase activity
HPG46_RS16630	COG0814	amino acid
HPG46_RS16660	COG1393	Belongs to the ArsC family
HPG46_RS16665	COG1733	regulation of RNA biosynthetic process
HPG46_RS16670	COG2188	Transcriptional regulator
HPG46_RS16675	COG0673	inositol 2-dehydrogenase activity
HPG46_RS16680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPG46_RS16685	COG1733	regulation of RNA biosynthetic process
HPG46_RS16690	COG1733	regulation of RNA biosynthetic process
HPG46_RS16710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS16730	COG0384	phenazine biosynthesis protein PhzF
HPG46_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS16755	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS16760	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPG46_RS16765	COG1733	regulation of RNA biosynthetic process
HPG46_RS16785	COG1191	sigma factor activity
HPG46_RS16800	COG1309	transcriptional regulator
HPG46_RS16820	COG3152	Membrane
HPG46_RS16845	COG1151	hydroxylamine reductase activity
HPG46_RS16855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS16860	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_RS16860	COG3757	hydrolase, family 25
HPG46_RS16895	COG2072	flavoprotein involved in K transport
HPG46_RS16935	COG1113	amino acid transport
HPG46_RS16940	COG2814	Major facilitator Superfamily
HPG46_RS16970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPG46_RS16975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPG46_RS16990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS16995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS17000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS17005	COG3739	integral membrane protein
HPG46_RS17010	COG0384	phenazine biosynthesis protein PhzF
HPG46_RS17040	COG0583	DNA-binding transcription factor activity
HPG46_RS17060	COG1193	negative regulation of DNA recombination
HPG46_RS17075	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HPG46_RS17080	COG1164	Oligoendopeptidase f
HPG46_RS17085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_RS17115	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_RS17140	COG0640	Transcriptional regulator
HPG46_RS17145	COG0604	alcohol dehydrogenase
HPG46_RS17155	COG0457	Tetratricopeptide repeat
HPG46_RS17165	COG0385	Bile acid
HPG46_RS17170	COG0277	FAD linked oxidase domain protein
HPG46_RS17205	COG1216	Glycosyl transferase, family 2
HPG46_RS17210	COG1024	Enoyl-CoA hydratase
HPG46_RS17220	COG1285	pathogenesis
HPG46_RS17235	COG2514	catechol 2,3-dioxygenase activity
HPG46_RS17240	COG2720	vancomycin resistance protein
HPG46_RS17280	COG0716	FMN binding
HPG46_RS17310	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS17320	COG0165	Argininosuccinate lyase
HPG46_RS17335	COG4145	pantothenate transmembrane transporter activity
HPG46_RS17345	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS17350	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS17360	COG1657	PFAM Prenyltransferase squalene oxidase
HPG46_RS17365	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HPG46_RS17370	COG2962	Rard protein
HPG46_RS17375	COG3326	Membrane
HPG46_RS17390	COG0489	protein tyrosine kinase activity
HPG46_RS17400	COG0314	molybdopterin synthase activity
HPG46_RS17405	COG0303	'Molybdopterin
HPG46_RS17410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_RS17415	COG2116	formate transmembrane transporter activity
HPG46_RS17425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPG46_RS17430	COG5609	conserved protein (DUF2294)
HPG46_RS17435	COG2427	Protein of unknown function (DUF1641)
HPG46_RS17440	COG3383	formate dehydrogenase (NAD+) activity
HPG46_RS17445	COG0697	spore germination
HPG46_RS17485	COG2226	methyltransferase
HPG46_RS17490	COG4166	transmembrane transport
HPG46_RS17495	COG4166	transmembrane transport
HPG46_RS17500	COG4166	transmembrane transport
HPG46_RS17505	COG1301	dicarboxylic acid transport
HPG46_RS17510	COG1316	TRANSCRIPTIONal
HPG46_RS17520	COG1595	DNA-templated transcription, initiation
HPG46_RS17540	COG1131	(ABC) transporter
HPG46_RS17550	COG0673	inositol 2-dehydrogenase activity
HPG46_RS17555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPG46_RS17560	COG0187	DNA topoisomerase II activity
HPG46_RS17565	COG1832	CoA-binding protein
HPG46_RS17570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPG46_RS17575	COG0745	RESPONSE REGULATOR receiver
HPG46_RS17595	COG4841	protein insertion into membrane
HPG46_RS17600	COG0824	Thioesterase
HPG46_RS17630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_RS17640	COG1132	(ABC) transporter
HPG46_RS17645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPG46_RS17685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPG46_RS17700	COG0183	Belongs to the thiolase family
HPG46_RS17705	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS17710	COG1268	BioY protein
HPG46_RS17715	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS17765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS17775	COG5002	protein histidine kinase activity
HPG46_RS17780	COG0400	carboxylic ester hydrolase activity
HPG46_RS17785	COG0346	lactoylglutathione lyase activity
HPG46_RS17790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPG46_RS17795	COG0069	glutamate synthase activity
HPG46_RS17800	COG1902	pentaerythritol trinitrate reductase activity
HPG46_RS17805	COG1329	Transcriptional regulator
HPG46_RS17810	COG0010	Belongs to the arginase family
HPG46_RS17835	COG2226	methyltransferase
HPG46_RS17870	COG4846	Membrane protein involved in cytochrome C biogenesis
HPG46_RS17875	COG0785	Cytochrome C biogenesis protein
HPG46_RS17885	COG1473	amidohydrolase
HPG46_RS17895	COG1131	(ABC) transporter
HPG46_RS17905	COG0583	DNA-binding transcription factor activity
HPG46_RS17915	COG1346	cytolysis
HPG46_RS17930	COG0730	response to heat
HPG46_RS17940	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPG46_RS17940	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_RS17955	COG1132	(ABC) transporter
HPG46_RS17960	COG1132	(ABC) transporter
HPG46_RS17985	COG3639	organic phosphonate transmembrane transporter activity
HPG46_RS18000	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS18010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPG46_RS18030	COG1695	Transcriptional regulator
HPG46_RS18040	COG0174	glutamine synthetase
HPG46_RS18045	COG0789	Transcriptional regulator
HPG46_RS18050	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HPG46_RS18055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPG46_RS18060	COG2860	membrane
HPG46_RS18065	COG0464	growth
HPG46_RS18095	COG1388	LysM domain
HPG46_RS18095	COG3584	3D domain protein
HPG46_RS18100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPG46_RS18100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPG46_RS18100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_RS18105	COG1105	Belongs to the carbohydrate kinase PfkB family
HPG46_RS18110	COG1349	DNA-binding transcription factor activity
HPG46_RS18115	COG1979	alcohol dehydrogenase
HPG46_RS18120	COG2322	membrane
HPG46_RS18130	COG1113	amino acid transport
HPG46_RS18145	COG1408	metallophosphoesterase
HPG46_RS18150	COG2116	formate transmembrane transporter activity
HPG46_RS18165	COG2217	Heavy metal translocating P-type atpase
HPG46_RS18170	COG2608	mercury ion transmembrane transporter activity
HPG46_RS18175	COG1937	Protein conserved in bacteria
HPG46_RS18185	COG2819	hydrolase of the alpha beta superfamily
HPG46_RS18190	COG1120	ATPase activity
HPG46_RS18195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS18200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS18205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS18210	COG0708	Exodeoxyribonuclease III
HPG46_RS18220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPG46_RS18225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPG46_RS18235	COG2364	Membrane
HPG46_RS18250	COG2267	carboxylic ester hydrolase activity
HPG46_RS18255	COG0346	lactoylglutathione lyase activity
HPG46_RS18260	COG5001	Diguanylate cyclase
HPG46_RS18260	COG3300	MHYT domain
HPG46_RS18275	COG1346	cytolysis
HPG46_RS18280	COG1380	Effector of murein hydrolase LrgA
HPG46_RS18285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS18295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPG46_RS18315	COG1404	Belongs to the peptidase S8 family
HPG46_RS18320	COG3773	Cell wall hydrolase
HPG46_RS18325	COG0562	UDP-galactopyranose mutase
HPG46_RS18330	COG1368	sulfuric ester hydrolase activity
HPG46_RS18335	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPG46_RS18345	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HPG46_RS18365	COG4550	Control of competence regulator ComK, YlbF/YmcA
HPG46_RS18375	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPG46_RS18380	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPG46_RS18380	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPG46_RS18390	COG2359	stage V sporulation protein S
HPG46_RS18395	COG1692	metallophosphoesterase
HPG46_RS18420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPG46_RS18425	COG1426	Protein conserved in bacteria
HPG46_RS18440	COG0300	oxidoreductase activity
HPG46_RS18445	COG0612	Peptidase, M16
HPG46_RS18450	COG0612	Peptidase, M16
HPG46_RS18455	COG1079	Belongs to the binding-protein-dependent transport system permease family
HPG46_RS18460	COG4603	Belongs to the binding-protein-dependent transport system permease family
HPG46_RS18465	COG3845	ABC transporter
HPG46_RS18470	COG1744	ABC transporter substrate-binding protein PnrA-like
HPG46_RS18475	COG2188	Transcriptional regulator
HPG46_RS18480	COG1674	ftsk spoiiie
HPG46_RS18490	COG0740	serine-type endopeptidase activity
HPG46_RS18495	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPG46_RS18505	COG0527	aspartate kinase activity
HPG46_RS18510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPG46_RS18515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPG46_RS18520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPG46_RS18525	COG1873	PFAM PRC-barrel domain
HPG46_RS18530	COG0612	Peptidase, M16
HPG46_RS18535	COG0726	polysaccharide deacetylase
HPG46_RS18550	COG0196	riboflavin kinase activity
HPG46_RS18555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPG46_RS18565	COG1550	Protein conserved in bacteria
HPG46_RS18575	COG1358	cellular component organization or biogenesis
HPG46_RS18580	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HPG46_RS18585	COG0195	Participates in both transcription termination and antitermination
HPG46_RS18605	COG0750	zinc metalloprotease
HPG46_RS18615	COG4589	Belongs to the CDS family
HPG46_RS18630	COG0528	UMP kinase activity
HPG46_RS18660	COG4974	Belongs to the 'phage' integrase family
HPG46_RS18670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPG46_RS18675	COG0758	DNA mediated transformation
HPG46_RS18680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPG46_RS18720	COG1837	Belongs to the UPF0109 family
HPG46_RS18730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPG46_RS18740	COG0552	protein localization to endoplasmic reticulum
HPG46_RS18745	COG1196	nuclear chromosome segregation
HPG46_RS18755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPG46_RS18760	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS18765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPG46_RS18780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPG46_RS18785	COG1461	Dihydroxyacetone kinase
HPG46_RS18790	COG1302	Protein conserved in bacteria
HPG46_RS18805	COG1564	THIamine pyrophosphokinase
HPG46_RS18810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPG46_RS18815	COG1162	GTPase activity
HPG46_RS18820	COG2815	serine threonine protein kinase
HPG46_RS18820	COG0515	serine threonine protein kinase
HPG46_RS18825	COG0631	protein serine/threonine phosphatase activity
HPG46_RS18835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPG46_RS18835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPG46_RS18845	COG0242	peptide deformylase activity
HPG46_RS18850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPG46_RS18855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPG46_RS18875	COG1561	YicC-like family, N-terminal region
HPG46_RS18880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPG46_RS18890	COG0006	proline dipeptidase activity
HPG46_RS18910	COG3069	C4-dicarboxylate transmembrane transporter activity
HPG46_RS18920	COG1011	Hydrolase
HPG46_RS18975	COG0564	pseudouridine synthase activity
HPG46_RS18995	COG3599	regulation of cell shape
HPG46_RS19000	COG2302	S4 RNA-binding domain
HPG46_RS19005	COG0762	integral membrane protein
HPG46_RS19015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPG46_RS19020	COG1496	oxidoreductase activity
HPG46_RS19025	COG1873	PFAM PRC-barrel domain
HPG46_RS19030	COG1191	sigma factor activity
HPG46_RS19035	COG1191	sigma factor activity
HPG46_RS19045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPG46_RS19050	COG0849	cell division
HPG46_RS19055	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPG46_RS19060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPG46_RS19070	COG0772	Belongs to the SEDS family
HPG46_RS19085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPG46_RS19090	COG0768	penicillin binding
HPG46_RS19095	COG0768	penicillin binding
HPG46_RS19100	COG4839	cell division protein FtsL
HPG46_RS19115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPG46_RS19130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPG46_RS19135	COG1399	metal-binding, possibly nucleic acid-binding protein
HPG46_RS19145	COG3480	Lon protease (S16) C-terminal proteolytic domain
HPG46_RS19150	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPG46_RS19155	COG3314	Sporulation integral membrane protein YlbJ
HPG46_RS19165	COG0742	ribosomal rna small subunit methyltransferase
HPG46_RS19180	COG3679	Belongs to the UPF0342 family
HPG46_RS19185	COG0406	alpha-ribazole phosphatase activity
HPG46_RS19200	COG2340	Cysteine-rich secretory protein family
HPG46_RS19215	COG3336	cytochrome c oxidase
HPG46_RS19250	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HPG46_RS19255	COG0772	Belongs to the SEDS family
HPG46_RS19265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPG46_RS19270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPG46_RS19280	COG4896	Protein conserved in bacteria
HPG46_RS19295	COG1217	gtp-binding protein TYPA
HPG46_RS19305	COG0483	inositol monophosphate 1-phosphatase activity
HPG46_RS19325	COG1982	Orn Lys Arg decarboxylase major
HPG46_RS19375	COG0022	dehydrogenase e1 component
HPG46_RS19380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPG46_RS19390	COG0242	peptide deformylase activity
HPG46_RS19395	COG0561	phosphatase activity
HPG46_RS19405	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPG46_RS19410	COG0569	domain protein
HPG46_RS19430	COG0583	DNA-binding transcription factor activity
HPG46_RS19435	COG0517	IMP dehydrogenase activity
HPG46_RS19445	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HPG46_RS19455	COG4703	Protein of unknown function (DUF1797)
HPG46_RS19470	COG2200	EAL domain
HPG46_RS19475	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS19480	COG1408	metallophosphoesterase
HPG46_RS19490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPG46_RS19525	COG2814	Major facilitator Superfamily
HPG46_RS19545	COG3209	COG3209 Rhs family protein
HPG46_RS19555	COG2205	protein histidine kinase activity
HPG46_RS19565	COG0436	Aminotransferase
HPG46_RS19570	COG1609	Transcriptional regulator
HPG46_RS19575	COG3833	ABC-type maltose transport systems, permease component
HPG46_RS19580	COG1175	transmembrane transport
HPG46_RS19585	COG2182	Extracellular solute-binding protein
HPG46_RS19595	COG0366	Alpha amylase catalytic
HPG46_RS19600	COG3842	ATPase activity
HPG46_RS19640	COG0183	Belongs to the thiolase family
HPG46_RS19675	COG1695	Transcriptional regulator
HPG46_RS19680	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS19690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HPG46_RS19700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPG46_RS19705	COG0436	Aminotransferase
HPG46_RS19740	COG2084	Dehydrogenase
HPG46_RS19745	COG2199	diguanylate cyclase activity
HPG46_RS19750	COG0778	Nitroreductase
HPG46_RS19775	COG2190	(PTS) system
HPG46_RS19775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS19775	COG1263	PTS System
HPG46_RS19780	COG3711	transcriptional antiterminator
HPG46_RS19790	COG2188	Transcriptional regulator
HPG46_RS19800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPG46_RS19825	COG1547	Domain of unknown function (DUF309)
HPG46_RS19830	COG0456	acetyltransferase
HPG46_RS19835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPG46_RS19840	COG4086	secreted protein
HPG46_RS19845	COG0561	phosphatase activity
HPG46_RS19850	COG0697	spore germination
HPG46_RS19865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS19890	COG0733	neurotransmitter:sodium symporter activity
HPG46_RS19910	COG1686	Belongs to the peptidase S11 family
HPG46_RS19915	COG1725	Transcriptional regulator
HPG46_RS19920	COG1131	(ABC) transporter
HPG46_RS19935	COG1846	Transcriptional regulator
HPG46_RS19950	COG0598	Magnesium transport protein CorA
HPG46_RS19975	COG4974	Belongs to the 'phage' integrase family
HPG46_RS19985	COG0735	belongs to the Fur family
HPG46_RS19990	COG1300	Membrane
HPG46_RS20010	COG0667	Aldo Keto reductase
HPG46_RS20015	COG0656	L-ascorbic acid biosynthetic process
HPG46_RS20020	COG0456	acetyltransferase
HPG46_RS20020	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPG46_RS20030	COG4085	toxin activity
HPG46_RS20030	COG1525	nuclease
HPG46_RS20030	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS20040	COG0596	Alpha beta hydrolase
HPG46_RS20045	COG2056	Na+-H+ antiporter family
HPG46_RS20050	COG1609	Transcriptional regulator
HPG46_RS20055	COG0456	acetyltransferase
HPG46_RS20060	COG1073	alpha beta
HPG46_RS20075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_RS20075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPG46_RS20080	COG0307	riboflavin synthase, alpha
HPG46_RS20105	COG4106	trans-aconitate 2-methyltransferase activity
HPG46_RS20110	COG1073	alpha beta
HPG46_RS20110	COG2226	methyltransferase
HPG46_RS20125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPG46_RS20135	COG1757	Na H antiporter
HPG46_RS20140	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS20150	COG1522	sequence-specific DNA binding
HPG46_RS20170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPG46_RS20180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPG46_RS20195	COG0300	oxidoreductase activity
HPG46_RS20200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS20205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_RS20210	COG1760	l-serine dehydratase
HPG46_RS20215	COG1760	l-serine dehydratase
HPG46_RS20235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPG46_RS20245	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPG46_RS20250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS20265	COG1376	ErfK ybiS ycfS ynhG family protein
HPG46_RS20270	COG4129	membrane
HPG46_RS20275	COG1126	abc transporter atp-binding protein
HPG46_RS20280	COG0765	amino acid transport
HPG46_RS20285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPG46_RS20300	COG2816	NAD+ diphosphatase activity
HPG46_RS20305	COG0772	Belongs to the SEDS family
HPG46_RS20310	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPG46_RS20315	COG0022	dehydrogenase e1 component
HPG46_RS20320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPG46_RS20325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPG46_RS20340	COG0280	phosphate acetyltransferase
HPG46_RS20345	COG3290	protein histidine kinase activity
HPG46_RS20345	COG3829	transcription factor binding
HPG46_RS20355	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_RS20360	COG3093	addiction module antidote protein HigA
HPG46_RS20370	COG0745	RESPONSE REGULATOR receiver
HPG46_RS20375	COG0750	zinc metalloprotease
HPG46_RS20380	COG0497	DNA recombination
HPG46_RS20390	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HPG46_RS20400	COG0142	geranyltranstransferase activity
HPG46_RS20425	COG1302	Protein conserved in bacteria
HPG46_RS20430	COG0439	Biotin carboxylase
HPG46_RS20435	COG0511	ligase activity, forming carbon-carbon bonds
HPG46_RS20480	COG3854	ATPases associated with a variety of cellular activities
HPG46_RS20505	COG0006	proline dipeptidase activity
HPG46_RS20520	COG3872	metal-dependent enzyme
HPG46_RS20530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPG46_RS20560	COG0095	Lipoate-protein ligase
HPG46_RS20565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS20570	COG1609	Transcriptional regulator
HPG46_RS20580	COG2076	Multidrug Resistance protein
HPG46_RS20585	COG2076	Multidrug Resistance protein
HPG46_RS20620	COG1131	(ABC) transporter
HPG46_RS20625	COG1725	Transcriptional regulator
HPG46_RS20655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPG46_RS20710	COG4970	Tfp pilus assembly protein FimT
HPG46_RS20720	COG1459	type II secretion system
HPG46_RS20725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPG46_RS20770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPG46_RS20775	COG0646	methionine synthase
HPG46_RS20775	COG1410	methionine synthase
HPG46_RS20780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPG46_RS20780	COG0646	methionine synthase
HPG46_RS20785	COG0626	cystathionine gamma-synthase activity
HPG46_RS20790	COG0626	cystathionine gamma-synthase activity
HPG46_RS20810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS20820	COG1940	carbohydrate kinase activity
HPG46_RS20825	COG4483	Protein conserved in bacteria
HPG46_RS20830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPG46_RS20835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPG46_RS20840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPG46_RS20845	COG0704	Plays a role in the regulation of phosphate uptake
HPG46_RS20855	COG0581	inorganic phosphate transmembrane transporter activity
HPG46_RS20860	COG0573	inorganic phosphate transmembrane transporter activity
HPG46_RS20865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPG46_RS20870	COG0768	penicillin binding
HPG46_RS20875	COG0477	Major facilitator Superfamily
HPG46_RS20880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPG46_RS20905	COG0735	belongs to the Fur family
HPG46_RS20910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPG46_RS20915	COG1121	(ABC) transporter
HPG46_RS20920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS20950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPG46_RS20955	COG2384	SAM-dependent methyltransferase
HPG46_RS20960	COG2010	Cytochrome c
HPG46_RS20965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPG46_RS20970	COG0358	DNA primase activity
HPG46_RS20980	COG0517	IMP dehydrogenase activity
HPG46_RS20995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPG46_RS21000	COG0295	cytidine deaminase activity
HPG46_RS21005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPG46_RS21015	COG1480	7TM receptor with intracellular HD hydrolase
HPG46_RS21020	COG1702	phosphate starvation-inducible protein PhoH
HPG46_RS21035	COG1610	YqeY-like protein
HPG46_RS21040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPG46_RS21045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPG46_RS21050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPG46_RS21080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPG46_RS21085	COG1733	regulation of RNA biosynthetic process
HPG46_RS21110	COG1466	dna polymerase III delta subunit
HPG46_RS21120	COG0658	competence protein
HPG46_RS21120	COG2333	competence protein COMEC
HPG46_RS21125	COG2131	deaminase
HPG46_RS21130	COG1555	photosystem II stabilization
HPG46_RS21130	COG1596	polysaccharide export
HPG46_RS21135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPG46_RS21140	COG2226	methyltransferase
HPG46_RS21145	COG0799	negative regulation of ribosome biogenesis
HPG46_RS21150	COG1713	HD superfamily hydrolase involved in NAD metabolism
HPG46_RS21160	COG1534	Rna-binding protein
HPG46_RS21170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HPG46_RS21175	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HPG46_RS21200	COG1595	DNA-templated transcription, initiation
HPG46_RS21210	COG0778	Nitroreductase
HPG46_RS21215	COG2357	RelA SpoT domain protein
HPG46_RS21225	COG1785	Belongs to the alkaline phosphatase family
HPG46_RS21235	COG2267	carboxylic ester hydrolase activity
HPG46_RS21270	COG1404	Belongs to the peptidase S8 family
HPG46_RS21275	COG3186	Phenylalanine-4-hydroxylase
HPG46_RS21285	COG2514	catechol 2,3-dioxygenase activity
HPG46_RS21290	COG2259	Doxx family
HPG46_RS21330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS21340	COG1012	belongs to the aldehyde dehydrogenase family
HPG46_RS21340	COG1454	alcohol dehydrogenase
HPG46_RS21345	COG0626	cystathionine gamma-synthase activity
HPG46_RS21350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPG46_RS21375	COG0768	penicillin binding
HPG46_RS21390	COG0826	peptidase U32
HPG46_RS21395	COG0826	peptidase U32
HPG46_RS21400	COG4122	O-methyltransferase activity
HPG46_RS21405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPG46_RS21435	COG0628	permease
HPG46_RS21455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPG46_RS21470	COG1104	cysteine desulfurase activity
HPG46_RS21475	COG1959	2 iron, 2 sulfur cluster binding
HPG46_RS21480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPG46_RS21490	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPG46_RS21520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPG46_RS21530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPG46_RS21530	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPG46_RS21535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPG46_RS21540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPG46_RS21540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPG46_RS21550	COG2244	polysaccharide biosynthetic process
HPG46_RS21555	COG2323	membrane
HPG46_RS21565	COG1862	Preprotein translocase
HPG46_RS21595	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HPG46_RS21605	COG0697	spore germination
HPG46_RS21610	COG0640	Transcriptional regulator
HPG46_RS21635	COG0157	Belongs to the NadC ModD family
HPG46_RS21640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPG46_RS21645	COG1104	cysteine desulfurase activity
HPG46_RS21650	COG1827	regulation of RNA biosynthetic process
HPG46_RS21655	COG2258	MOSC domain
HPG46_RS21660	COG0077	Prephenate dehydratase
HPG46_RS21665	COG0577	efflux transmembrane transporter activity
HPG46_RS21670	COG0577	efflux transmembrane transporter activity
HPG46_RS21675	COG1136	(ABC) transporter
HPG46_RS21680	COG5002	protein histidine kinase activity
HPG46_RS21685	COG0745	RESPONSE REGULATOR receiver
HPG46_RS21695	COG3290	protein histidine kinase activity
HPG46_RS21705	COG2868	ribosomal protein
HPG46_RS21715	COG1530	ribonuclease E activity
HPG46_RS21720	COG1994	Peptidase M50
HPG46_RS21725	COG0739	heme binding
HPG46_RS21730	COG2894	cell division
HPG46_RS21750	COG1077	Cell shape determining protein MreB Mrl
HPG46_RS21770	COG0285	dihydrofolate synthase activity
HPG46_RS21775	COG0525	valine-tRNA ligase activity
HPG46_RS21785	COG1388	LysM domain
HPG46_RS21795	COG0113	porphobilinogen synthase activity
HPG46_RS21800	COG1587	Uroporphyrinogen-III synthase
HPG46_RS21810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPG46_RS21820	COG1846	Transcriptional regulator
HPG46_RS21825	COG1764	response to oxidative stress
HPG46_RS21840	COG0470	DNA polymerase III
HPG46_RS21840	COG1067	ATP-dependent peptidase activity
HPG46_RS21890	COG0622	Phosphoesterase
HPG46_RS21905	COG5401	PFAM Sporulation and spore germination
HPG46_RS21925	COG1309	transcriptional regulator
HPG46_RS21940	COG2197	response regulator
HPG46_RS21945	COG2233	PERMEase
HPG46_RS21955	COG0402	S-adenosylhomocysteine deaminase activity
HPG46_RS21960	COG0402	S-adenosylhomocysteine deaminase activity
HPG46_RS21970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPG46_RS21980	COG0444	Belongs to the ABC transporter superfamily
HPG46_RS21985	COG4608	Belongs to the ABC transporter superfamily
HPG46_RS21990	COG3275	phosphorelay sensor kinase activity
HPG46_RS21995	COG3279	Response regulator of the LytR AlgR family
HPG46_RS22005	COG1983	PspC domain protein
HPG46_RS22010	COG1396	sequence-specific DNA binding
HPG46_RS22015	COG0697	spore germination
HPG46_RS22025	COG1959	2 iron, 2 sulfur cluster binding
HPG46_RS22030	COG1668	transmembrane transport
HPG46_RS22035	COG4152	abc transporter atp-binding protein
HPG46_RS22040	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HPG46_RS22045	COG1360	Flagellar Motor Protein
HPG46_RS22050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPG46_RS22055	COG1876	peptidase activity
HPG46_RS22060	COG0824	Thioesterase
HPG46_RS22065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPG46_RS22070	COG1053	succinate dehydrogenase
HPG46_RS22075	COG2009	succinate dehydrogenase
HPG46_RS22080	COG1719	4-vinyl reductase, 4VR
HPG46_RS22090	COG3118	belongs to the thioredoxin family
HPG46_RS22095	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPG46_RS22100	COG2086	electron transfer activity
HPG46_RS22105	COG1024	Enoyl-CoA hydratase
HPG46_RS22110	COG1309	transcriptional regulator
HPG46_RS22115	COG0318	PFAM AMP-dependent synthetase and ligase
HPG46_RS22135	COG2318	DinB family
HPG46_RS22155	COG1131	(ABC) transporter
HPG46_RS22160	COG2205	protein histidine kinase activity
HPG46_RS22165	COG0745	RESPONSE REGULATOR receiver
HPG46_RS22175	COG4895	conserved protein (DUF2196)
HPG46_RS22180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPG46_RS22195	COG4509	Sortase family
HPG46_RS22200	COG1120	ATPase activity
HPG46_RS22215	COG5386	Cell surface protein
HPG46_RS22220	COG5386	Cell surface protein
HPG46_RS22225	COG1114	Component of the transport system for branched-chain amino acids
HPG46_RS22230	COG1187	pseudouridine synthase activity
HPG46_RS22240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPG46_RS22240	COG1796	DNA polymerase
HPG46_RS22245	COG1286	toxin biosynthetic process
HPG46_RS22290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPG46_RS22300	COG1418	mRNA catabolic process
HPG46_RS22310	COG2814	Major facilitator Superfamily
HPG46_RS22315	COG1566	PFAM secretion protein HlyD family protein
HPG46_RS22320	COG1309	transcriptional regulator
HPG46_RS22325	COG1363	Peptidase, m42
HPG46_RS22350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPG46_RS22360	COG1484	DNA-dependent DNA replication
HPG46_RS22365	COG3611	Membrane attachment protein
HPG46_RS22375	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPG46_RS22380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPG46_RS22385	COG0237	dephospho-CoA kinase activity
HPG46_RS22390	COG1971	Probably functions as a manganese efflux pump
HPG46_RS22400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPG46_RS22400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPG46_RS22405	COG5002	protein histidine kinase activity
HPG46_RS22410	COG0745	RESPONSE REGULATOR receiver
HPG46_RS22430	COG0538	isocitrate dehydrogenase activity
HPG46_RS22435	COG0372	Belongs to the citrate synthase family
HPG46_RS22445	COG0628	permease
HPG46_RS22450	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPG46_RS22475	COG1725	Transcriptional regulator
HPG46_RS22480	COG0281	malic enzyme
HPG46_RS22485	COG0587	DNA-directed DNA polymerase activity
HPG46_RS22500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPG46_RS22520	COG4109	DRTGG domain
HPG46_RS22535	COG0006	proline dipeptidase activity
HPG46_RS22575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS22580	COG0662	Cupin 2, conserved barrel domain protein
HPG46_RS22590	COG1476	TRANSCRIPTIONal
HPG46_RS22605	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS22610	COG0589	response to stress
HPG46_RS22650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS22670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPG46_RS22675	COG0827	DNA restriction-modification system
HPG46_RS22680	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPG46_RS22685	COG3874	Sporulation protein YtfJ
HPG46_RS22700	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPG46_RS22710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPG46_RS22725	COG1104	cysteine desulfurase activity
HPG46_RS22735	COG0583	DNA-binding transcription factor activity
HPG46_RS22740	COG0697	spore germination
HPG46_RS22745	COG1309	transcriptional regulator
HPG46_RS22750	COG1956	GAF domain-containing protein
HPG46_RS22755	COG0626	cystathionine gamma-synthase activity
HPG46_RS22810	COG1595	DNA-templated transcription, initiation
HPG46_RS22820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPG46_RS22825	COG0454	-acetyltransferase
HPG46_RS22830	COG0517	IMP dehydrogenase activity
HPG46_RS22835	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPG46_RS22850	COG0745	RESPONSE REGULATOR receiver
HPG46_RS22855	COG5002	protein histidine kinase activity
HPG46_RS22860	COG0666	response to abiotic stimulus
HPG46_RS22895	COG1609	Transcriptional regulator
HPG46_RS22900	COG4851	CamS sex pheromone cAM373 precursor
HPG46_RS22905	COG3118	belongs to the thioredoxin family
HPG46_RS22915	COG2309	aminopeptidase activity
HPG46_RS22935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS22940	COG1695	Transcriptional regulator
HPG46_RS22960	COG1674	ftsk spoiiie
HPG46_RS22970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPG46_RS22980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_RS22985	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HPG46_RS22990	COG1363	Peptidase, m42
HPG46_RS23000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS23015	COG0510	thiamine kinase activity
HPG46_RS23020	COG1523	belongs to the glycosyl hydrolase 13 family
HPG46_RS23030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPG46_RS23035	COG1349	DNA-binding transcription factor activity
HPG46_RS23040	COG1187	pseudouridine synthase activity
HPG46_RS23045	COG2244	polysaccharide biosynthetic process
HPG46_RS23050	COG2081	HI0933 family
HPG46_RS23055	COG2814	Major facilitator Superfamily
HPG46_RS23065	COG3832	glyoxalase III activity
HPG46_RS23085	COG1329	Transcriptional regulator
HPG46_RS23110	COG0314	molybdopterin synthase activity
HPG46_RS23115	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPG46_RS23120	COG0303	'Molybdopterin
HPG46_RS23130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPG46_RS23135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPG46_RS23155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPG46_RS23165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPG46_RS23205	COG2814	Major facilitator Superfamily
HPG46_RS23210	COG0475	glutathione-regulated potassium exporter activity
HPG46_RS23215	COG0490	domain, Protein
HPG46_RS23220	COG0582	viral genome integration into host DNA
HPG46_RS23230	COG1136	(ABC) transporter
HPG46_RS23250	COG1242	4 iron, 4 sulfur cluster binding
HPG46_RS23255	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HPG46_RS23270	COG1794	racemase activity, acting on amino acids and derivatives
HPG46_RS23280	COG5504	Zn-dependent protease
HPG46_RS23305	COG2267	carboxylic ester hydrolase activity
HPG46_RS23310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPG46_RS23315	COG0671	phosphoesterase, PA-phosphatase related
HPG46_RS23320	COG0438	transferase activity, transferring glycosyl groups
HPG46_RS23330	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPG46_RS23385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPG46_RS23390	COG5002	protein histidine kinase activity
HPG46_RS23395	COG4191	Histidine kinase
HPG46_RS23400	COG2267	carboxylic ester hydrolase activity
HPG46_RS23405	COG1368	sulfuric ester hydrolase activity
HPG46_RS23420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPG46_RS23425	COG1116	anion transmembrane transporter activity
HPG46_RS23430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPG46_RS23445	COG0546	phosphoglycolate phosphatase activity
HPG46_RS23455	COG0494	nUDIX hydrolase
HPG46_RS23485	COG0288	reversible hydration of carbon dioxide
HPG46_RS23490	COG1271	oxidase subunit
HPG46_RS23495	COG1294	oxidase, subunit
HPG46_RS23515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS23540	COG1842	Phage shock protein A
HPG46_RS23585	COG5002	protein histidine kinase activity
HPG46_RS23590	COG0745	RESPONSE REGULATOR receiver
HPG46_RS23615	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HPG46_RS23620	COG1597	lipid kinase activity
HPG46_RS23635	COG0577	efflux transmembrane transporter activity
HPG46_RS23640	COG1136	(ABC) transporter
HPG46_RS23655	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS23665	COG4977	sequence-specific DNA binding
HPG46_RS23675	COG0577	efflux transmembrane transporter activity
HPG46_RS23680	COG1136	(ABC) transporter
HPG46_RS23685	COG3708	Transcriptional regulator
HPG46_RS23685	COG2207	Transcriptional regulator
HPG46_RS23695	COG5658	integral membrane protein
HPG46_RS23705	COG0745	RESPONSE REGULATOR receiver
HPG46_RS23710	COG2205	protein histidine kinase activity
HPG46_RS23715	COG0577	efflux transmembrane transporter activity
HPG46_RS23720	COG0577	efflux transmembrane transporter activity
HPG46_RS23725	COG1136	(ABC) transporter
HPG46_RS23730	COG0577	efflux transmembrane transporter activity
HPG46_RS23745	COG2188	Transcriptional regulator
HPG46_RS23765	COG3964	amidohydrolase
HPG46_RS23785	COG4948	Mandelate Racemase Muconate Lactonizing
HPG46_RS23795	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPG46_RS23800	COG0596	Alpha beta hydrolase
HPG46_RS23805	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPG46_RS23810	COG1169	isochorismate synthase
HPG46_RS23815	COG1575	Belongs to the MenA family. Type 1 subfamily
HPG46_RS23820	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPG46_RS23840	COG0058	SHG alpha-glucan phosphorylase activity
HPG46_RS23850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPG46_RS23870	COG1404	Belongs to the peptidase S8 family
HPG46_RS23970	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPG46_RS24005	COG1285	pathogenesis
HPG46_RS24010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPG46_RS24025	COG2155	Conserved Protein
HPG46_RS24030	COG1098	S1 RNA binding domain
HPG46_RS24035	COG0436	Aminotransferase
HPG46_RS24040	COG1522	sequence-specific DNA binding
HPG46_RS24045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPG46_RS24050	COG2267	carboxylic ester hydrolase activity
HPG46_RS24060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPG46_RS24080	COG5018	Exonuclease
HPG46_RS24085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPG46_RS24105	COG2050	protein possibly involved in aromatic compounds catabolism
HPG46_RS24115	COG1268	BioY protein
HPG46_RS24120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPG46_RS24125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPG46_RS24140	COG3584	3D domain protein
HPG46_RS24155	COG1252	NADH dehydrogenase
HPG46_RS24170	COG3708	Transcriptional regulator
HPG46_RS24185	COG1683	Conserved Protein
HPG46_RS24205	COG0316	Belongs to the HesB IscA family
HPG46_RS24220	COG1252	NADH dehydrogenase
HPG46_RS24235	COG0390	transport system, permease component
HPG46_RS24240	COG2824	Alkylphosphonate utilization operon protein PhnA
HPG46_RS24260	COG4837	Protein of unknown function (DUF1462)
HPG46_RS24265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPG46_RS24275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPG46_RS24280	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPG46_RS24295	COG1136	(ABC) transporter
HPG46_RS24295	COG0577	efflux transmembrane transporter activity
HPG46_RS24300	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPG46_RS24310	COG0647	UMP catabolic process
HPG46_RS24320	COG2445	Protein of unknown function DUF86
HPG46_RS24325	COG1494	fructose-1,6-bisphosphatase
HPG46_RS24340	COG4470	Protein conserved in bacteria
HPG46_RS24350	COG0789	Transcriptional regulator
HPG46_RS24355	COG4377	Putative membrane peptidase family (DUF2324)
HPG46_RS24380	COG0739	heme binding
HPG46_RS24390	COG3377	Domain of unknown function (DUF1805)
HPG46_RS24395	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS24400	COG1695	Transcriptional regulator
HPG46_RS24410	COG0719	Fe-S assembly protein
HPG46_RS24415	COG0822	iron-sulfur transferase activity
HPG46_RS24420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPG46_RS24425	COG0719	Fe-S assembly protein
HPG46_RS24430	COG0396	ATPase activity
HPG46_RS24435	COG1464	Belongs to the NlpA lipoprotein family
HPG46_RS24440	COG1464	Belongs to the NlpA lipoprotein family
HPG46_RS24445	COG2011	ABC-type metal ion transport system permease component
HPG46_RS24460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPG46_RS24465	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPG46_RS24475	COG1393	Belongs to the ArsC family
HPG46_RS24540	COG1309	transcriptional regulator
HPG46_RS24545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPG46_RS24550	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS24555	COG0183	Belongs to the thiolase family
HPG46_RS24560	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPG46_RS24560	COG1024	Enoyl-CoA hydratase
HPG46_RS24570	COG1686	Belongs to the peptidase S11 family
HPG46_RS24585	COG0011	TIGRFAM Protein of
HPG46_RS24590	COG0840	transmembrane signaling receptor activity
HPG46_RS24610	COG2814	Major facilitator Superfamily
HPG46_RS24615	COG0531	amino acid
HPG46_RS24625	COG0706	membrane insertase activity
HPG46_RS24635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPG46_RS24675	COG0586	Pfam SNARE associated Golgi protein
HPG46_RS24685	COG1376	ErfK ybiS ycfS ynhG family protein
HPG46_RS24690	COG0745	RESPONSE REGULATOR receiver
HPG46_RS24695	COG5002	protein histidine kinase activity
HPG46_RS24720	COG0840	transmembrane signaling receptor activity
HPG46_RS24725	COG2151	metal-sulfur cluster biosynthetic enzyme
HPG46_RS24730	COG3227	Zinc metalloprotease (Elastase)
HPG46_RS24735	COG1741	Belongs to the pirin family
HPG46_RS24750	COG0475	glutathione-regulated potassium exporter activity
HPG46_RS24755	COG0490	domain, Protein
HPG46_RS24760	COG1115	amino acid carrier protein
HPG46_RS24765	COG0783	Belongs to the Dps family
HPG46_RS24780	COG1611	Belongs to the LOG family
HPG46_RS24800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS24805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS24810	COG1115	amino acid carrier protein
HPG46_RS24815	COG1115	amino acid carrier protein
HPG46_RS24820	COG2910	NAD(P)H-binding
HPG46_RS24840	COG0656	L-ascorbic acid biosynthetic process
HPG46_RS24845	COG2814	Major facilitator Superfamily
HPG46_RS24850	COG1733	regulation of RNA biosynthetic process
HPG46_RS24860	COG1252	NADH dehydrogenase
HPG46_RS24865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPG46_RS24870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPG46_RS24880	COG0840	transmembrane signaling receptor activity
HPG46_RS24880	COG3290	protein histidine kinase activity
HPG46_RS24910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS24970	COG0557	exoribonuclease II activity
HPG46_RS24975	COG1647	Serine aminopeptidase, S33
HPG46_RS24980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPG46_RS24985	COG1346	cytolysis
HPG46_RS25020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPG46_RS25035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPG46_RS25055	COG0457	Tetratricopeptide repeat
HPG46_RS25090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPG46_RS25105	COG2323	membrane
HPG46_RS25115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_RS25125	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPG46_RS25135	COG1051	belongs to the nudix hydrolase family
HPG46_RS25145	COG0492	ferredoxin-NADP+ reductase activity
HPG46_RS25150	COG0457	Tetratricopeptide repeat
HPG46_RS25155	COG0110	maltose O-acetyltransferase activity
HPG46_RS25175	COG1950	PFAM Membrane protein of
HPG46_RS25185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPG46_RS25205	COG0789	Transcriptional regulator
HPG46_RS25235	COG2855	membrane
HPG46_RS25240	COG0583	DNA-binding transcription factor activity
HPG46_RS25250	COG0655	NAD(P)H dehydrogenase (quinone) activity
HPG46_RS25265	COG1132	(ABC) transporter
HPG46_RS25275	COG0583	DNA-binding transcription factor activity
HPG46_RS25280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPG46_RS25285	COG0793	Belongs to the peptidase S41A family
HPG46_RS25285	COG3409	Peptidoglycan-binding domain 1 protein
HPG46_RS25290	COG2177	Part of the ABC transporter FtsEX involved in
HPG46_RS25295	COG2884	Cell division ATP-binding protein ftsE
HPG46_RS25315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPG46_RS25320	COG1278	Cold shock
HPG46_RS25325	COG1040	competence protein
HPG46_RS25330	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HPG46_RS25335	COG0791	NLP P60 protein
HPG46_RS25335	COG1388	LysM domain
HPG46_RS25340	COG1733	regulation of RNA biosynthetic process
HPG46_RS25345	COG1307	EDD domain protein, DegV family
HPG46_RS25350	COG1739	Uncharacterized protein family UPF0029
HPG46_RS25355	COG1316	TRANSCRIPTIONal
HPG46_RS25360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPG46_RS25365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPG46_RS25370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPG46_RS25380	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HPG46_RS25380	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPG46_RS25400	COG1486	melibiose metabolic process
HPG46_RS25405	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_RS25410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_RS25420	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPG46_RS25430	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPG46_RS25440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPG46_RS25445	COG1301	dicarboxylic acid transport
HPG46_RS25455	COG0346	lactoylglutathione lyase activity
HPG46_RS25460	COG1511	domain protein
HPG46_RS25465	COG0583	DNA-binding transcription factor activity
HPG46_RS25470	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HPG46_RS25480	COG1271	oxidase subunit
HPG46_RS25485	COG1294	oxidase, subunit
HPG46_RS25490	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPG46_RS25520	COG1620	l-lactate permease
HPG46_RS25530	COG2389	metal-binding protein
HPG46_RS25540	COG1368	sulfuric ester hydrolase activity
HPG46_RS25550	COG1388	LysM domain
HPG46_RS25550	COG0791	NLP P60 protein
HPG46_RS25555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPG46_RS25565	COG1215	transferase activity, transferring glycosyl groups
HPG46_RS25570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPG46_RS25575	COG1388	LysM domain
HPG46_RS25575	COG3584	3D domain protein
HPG46_RS25600	COG4715	Zinc finger, swim domain protein
HPG46_RS25605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPG46_RS25645	COG0577	efflux transmembrane transporter activity
HPG46_RS25650	COG1136	(ABC) transporter
HPG46_RS25670	COG2271	Major facilitator Superfamily
HPG46_RS25685	COG5002	protein histidine kinase activity
HPG46_RS25690	COG0745	RESPONSE REGULATOR receiver
HPG46_RS25695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPG46_RS25720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPG46_RS25725	COG1134	teichoic acid transport
HPG46_RS25730	COG1682	transport, permease protein
HPG46_RS25735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPG46_RS25755	COG1216	Glycosyl transferase, family 2
HPG46_RS25755	COG1442	glycosyl transferase family 8
HPG46_RS25775	COG1609	Transcriptional regulator
HPG46_RS25780	COG0726	polysaccharide deacetylase
HPG46_RS25790	COG0739	heme binding
HPG46_RS25805	COG3279	Response regulator of the LytR AlgR family
HPG46_RS25810	COG2385	sporulation resulting in formation of a cellular spore
HPG46_RS25825	COG4836	Membrane
HPG46_RS25830	COG1007	ATP synthesis coupled electron transport
HPG46_RS25835	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPG46_RS25840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPG46_RS25850	COG0839	Belongs to the complex I subunit 6 family
HPG46_RS25865	COG0649	NAD binding
HPG46_RS25870	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPG46_RS25885	COG3300	MHYT domain
HPG46_RS25885	COG5001	Diguanylate cyclase
HPG46_RS25935	COG0356	it plays a direct role in the translocation of protons across the membrane
HPG46_RS25970	COG0698	ribose 5-phosphate isomerase
HPG46_RS25980	COG2190	(PTS) system
HPG46_RS25985	COG2259	Doxx family
HPG46_RS25990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPG46_RS26005	COG0009	L-threonylcarbamoyladenylate synthase
HPG46_RS26020	COG2890	protein-(glutamine-N5) methyltransferase activity
HPG46_RS26040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPG46_RS26045	COG1494	fructose-1,6-bisphosphatase
HPG46_RS26065	COG4821	SIS domain
HPG46_RS26085	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS26090	COG1960	acyl-CoA dehydrogenase activity
HPG46_RS26095	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPG46_RS26100	COG0183	Belongs to the thiolase family
HPG46_RS26105	COG2181	nitrate reductase activity
HPG46_RS26105	COG0247	lactate metabolic process
HPG46_RS26110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPG46_RS26120	COG5001	Diguanylate cyclase
HPG46_RS26120	COG3300	MHYT domain
HPG46_RS26140	COG2197	response regulator
HPG46_RS26145	COG4585	Histidine kinase
HPG46_RS26150	COG0842	Transport permease protein
HPG46_RS26155	COG1131	(ABC) transporter
HPG46_RS26160	COG0024	Methionine aminopeptidase
HPG46_RS26170	COG2234	aminopeptidase activity
HPG46_RS26190	COG1595	DNA-templated transcription, initiation
HPG46_RS26200	COG4506	Protein conserved in bacteria
HPG46_RS26205	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPG46_RS26220	COG0010	Belongs to the arginase family
HPG46_RS26230	COG2814	Major facilitator Superfamily
HPG46_RS26235	COG0789	Transcriptional regulator
HPG46_RS26240	COG0584	glycerophosphoryl diester phosphodiesterase
HPG46_RS26245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPG46_RS26255	COG1994	Peptidase M50
HPG46_RS26265	COG1078	dGTPase activity
HPG46_RS26270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPG46_RS26275	COG1120	ATPase activity
HPG46_RS26280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS26285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPG46_RS26305	COG0095	Lipoate-protein ligase
HPG46_RS26310	COG0280	phosphate acetyltransferase
HPG46_RS26325	COG3773	Cell wall hydrolase
HPG46_RS26335	COG2363	Small membrane protein
HPG46_RS26345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPG46_RS26350	COG2233	PERMEase
HPG46_RS26355	COG0561	phosphatase activity
HPG46_RS26360	COG2814	Major facilitator Superfamily
HPG46_RS26370	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPG46_RS26375	COG1131	(ABC) transporter
HPG46_RS26380	COG2755	lipolytic protein G-D-S-L family
HPG46_RS26385	COG1609	Transcriptional regulator
HPG46_RS26395	COG0460	homoserine dehydrogenase
HPG46_RS26405	COG2873	o-acetylhomoserine
HPG46_RS26415	COG1011	Hydrolase
HPG46_RS26420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPG46_RS26430	COG2197	response regulator
HPG46_RS26435	COG4585	Histidine kinase
HPG46_RS26435	COG2203	Gaf domain
HPG46_RS26440	COG0351	phosphomethylpyrimidine kinase
HPG46_RS26445	COG3706	GGDEF domain
HPG46_RS26450	COG2879	small protein
HPG46_RS26455	COG1966	Carbon starvation protein
HPG46_RS26460	COG3279	Response regulator of the LytR AlgR family
HPG46_RS26465	COG0477	Major facilitator Superfamily
HPG46_RS26490	COG0840	transmembrane signaling receptor activity
HPG46_RS26500	COG1607	acyl-coa hydrolase
HPG46_RS26515	COG0488	(ABC) transporter
HPG46_RS26535	COG0463	Glycosyl transferase, family 2
HPG46_RS26540	COG1309	transcriptional regulator
HPG46_RS26545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPG46_RS26550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPG46_RS26550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPG46_RS26555	COG0628	permease
HPG46_RS26570	COG3279	Response regulator of the LytR AlgR family
HPG46_RS26575	COG3275	phosphorelay sensor kinase activity
HPG46_RS26580	COG2814	Major facilitator Superfamily
HPG46_RS26585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPG46_RS26590	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HPG46_RS26595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPG46_RS26615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPG46_RS26620	COG1272	protein, Hemolysin III
HPG46_RS26645	COG1164	Oligoendopeptidase f
HPG46_RS26665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPG46_RS26670	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HPG46_RS26675	COG4853	Protein conserved in bacteria
HPG46_RS26680	COG4863	YycH protein
HPG46_RS26685	COG5002	protein histidine kinase activity
HPG46_RS26690	COG0745	RESPONSE REGULATOR receiver
HPG46_RS26720	COG0305	Participates in initiation and elongation during chromosome replication
HPG46_RS26730	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HPG46_RS26735	COG4241	membrane
HPG46_RS26745	COG0629	single-stranded DNA binding
HPG46_RS26755	COG0012	GTP binding
HPG46_RS26760	COG4481	Protein conserved in bacteria
HPG46_RS26765	COG0668	transmembrane transport
HPG46_RS26775	COG1475	DNA binding
HPG46_RS26780	COG1192	Involved in chromosome partitioning
HPG46_RS26805	COG1847	R3H domain protein
HPG46_RS26810	COG0706	membrane insertase activity
HPG46_RS26820	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPG46_RS26875	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPG46_RS26980	COG0582	viral genome integration into host DNA
HPG46_RS26985	COG1396	sequence-specific DNA binding
HPG46_RS27000	COG0667	Aldo Keto reductase
HPG46_RS27055	COG1404	Belongs to the peptidase S8 family
HPG46_RS27070	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPG46_RS27145	COG1923	regulation of RNA biosynthetic process
HPG46_RS27150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPG46_RS27160	COG3443	Belongs to the bacterial solute-binding protein 9 family
HPG46_RS27195	COG2814	Major facilitator Superfamily
HPG46_RS27225	COG0745	RESPONSE REGULATOR receiver
HPG46_RS27230	COG2205	protein histidine kinase activity
HPG46_RS27260	COG2211	Major facilitator Superfamily
HPG46_RS27285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPG46_RS27310	COG0737	Belongs to the 5'-nucleotidase family
HPG46_RS27315	COG1475	DNA binding
HPG46_RS27320	COG0546	phosphoglycolate phosphatase activity
HPG46_RS27365	COG0457	Tetratricopeptide repeat
HPG46_RS27375	COG1414	Transcriptional regulator
HPG46_RS27385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPG46_RS27390	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HPG46_RS27395	COG1028	Short-chain dehydrogenase reductase Sdr
HPG46_RS27405	COG3715	PTS system
HPG46_RS27410	COG3716	PTS system mannose fructose sorbose family IID component
HPG46_RS27415	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPG46_RS27415	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPG46_RS27420	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HPG46_RS27430	COG5492	domain, Protein
HPG46_RS27440	COG1266	CAAX protease self-immunity
HPG46_RS27445	COG2207	Transcriptional regulator
HPG46_RS27455	COG2017	converts alpha-aldose to the beta-anomer
HPG46_RS27460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPG46_RS27465	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HPG46_RS27475	COG4974	Belongs to the 'phage' integrase family
HPG46_RS27490	COG1404	Belongs to the peptidase S8 family
HPG46_RS27500	COG2304	oxidoreductase activity
HPG46_RS27525	COG0531	amino acid
HPG46_RS27540	COG0534	Mate efflux family protein
HPG46_RS27550	COG2184	nucleotidyltransferase activity
HPG46_RS27555	COG2814	Major facilitator Superfamily
HPG46_RS27560	COG1309	transcriptional regulator
HPG46_RS27575	COG0814	amino acid
HPG46_RS27580	COG1760	l-serine dehydratase
HPG46_RS27585	COG1760	l-serine dehydratase
HPG46_RS27590	COG2184	nucleotidyltransferase activity
HPG46_RS27615	COG2133	pyrroloquinoline quinone binding
HPG46_RS27615	COG5183	chlorophyll binding
HPG46_RS27635	COG0840	transmembrane signaling receptor activity
HPG46_RS27655	COG1396	sequence-specific DNA binding
HPG46_RS27665	COG2312	Erythromycin esterase
HPG46_RS27700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPG46_RS27745	COG0456	acetyltransferase
HPG46_RS27760	COG2309	aminopeptidase activity
HPG46_RS27770	COG4221	oxidoreductase activity
HPG46_RS27780	COG1309	transcriptional regulator
HPG46_RS27790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPG46_RS27815	COG1136	(ABC) transporter
HPG46_RS27820	COG0577	efflux transmembrane transporter activity
HPG46_RS27850	COG2814	Major facilitator Superfamily
HPG46_RS27870	COG2329	Antibiotic biosynthesis monooxygenase
HPG46_RS27955	COG2311	Membrane
HPG46_RS27960	COG1073	alpha beta
HPG46_RS27980	COG3227	Zinc metalloprotease (Elastase)
HPG46_RS27985	COG0739	heme binding
HPG46_RS28205	COG4962	Type ii secretion system protein e
HPG46_RS28300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPG46_RS28390	COG1404	Belongs to the peptidase S8 family
HPG46_RS28455	COG3397	chitin binding
HPG46_RS28465	COG2373	Large extracellular alpha-helical protein
HPG46_RS28555	COG2234	aminopeptidase activity
HPG46_RS28595	COG1196	nuclear chromosome segregation
HPG46_RS28595	COG0741	lytic transglycosylase activity
HPG46_RS28595	COG0739	heme binding
HPG46_RS28665	COG4585	Histidine kinase
HPG46_RS28670	COG2197	response regulator
HPG46_RS28675	COG1404	Belongs to the peptidase S8 family
HPG46_RS28815	COG1395	domain, Protein
HPG46_RS28825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins