locus-tag	class	description
AW22_RS00085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AW22_RS00105	COG0587	DNA-directed DNA polymerase activity
AW22_RS00110	COG0587	DNA-directed DNA polymerase activity
AW22_RS00280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AW22_RS00285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AW22_RS00365	COG1566	PFAM secretion protein HlyD family protein
AW22_RS01105	COG0589	response to stress
AW22_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS01125	COG1476	TRANSCRIPTIONal
AW22_RS01135	COG0662	Cupin 2, conserved barrel domain protein
AW22_RS01180	COG0006	proline dipeptidase activity
AW22_RS01195	COG4109	DRTGG domain
AW22_RS01215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AW22_RS01230	COG0587	DNA-directed DNA polymerase activity
AW22_RS01235	COG0281	malic enzyme
AW22_RS01240	COG1725	Transcriptional regulator
AW22_RS01265	COG3030	protein affecting phage T7 exclusion by the F plasmid
AW22_RS01270	COG0628	permease
AW22_RS01285	COG0372	Belongs to the citrate synthase family
AW22_RS01290	COG0538	isocitrate dehydrogenase activity
AW22_RS01310	COG0745	RESPONSE REGULATOR receiver
AW22_RS01315	COG5002	protein histidine kinase activity
AW22_RS01320	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW22_RS01320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW22_RS01330	COG1971	Probably functions as a manganese efflux pump
AW22_RS01335	COG0237	dephospho-CoA kinase activity
AW22_RS01340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AW22_RS01345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AW22_RS01355	COG3611	Membrane attachment protein
AW22_RS01360	COG1484	DNA-dependent DNA replication
AW22_RS01370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AW22_RS01395	COG1363	Peptidase, m42
AW22_RS01400	COG1309	transcriptional regulator
AW22_RS01405	COG1566	PFAM secretion protein HlyD family protein
AW22_RS01410	COG2814	Major facilitator Superfamily
AW22_RS01445	COG1418	mRNA catabolic process
AW22_RS01455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AW22_RS01500	COG1286	toxin biosynthetic process
AW22_RS01505	COG1796	DNA polymerase
AW22_RS01505	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AW22_RS01520	COG1187	pseudouridine synthase activity
AW22_RS01525	COG1114	Component of the transport system for branched-chain amino acids
AW22_RS01530	COG5386	Cell surface protein
AW22_RS01535	COG5386	Cell surface protein
AW22_RS01550	COG1120	ATPase activity
AW22_RS01555	COG4509	Sortase family
AW22_RS01570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AW22_RS01575	COG4895	conserved protein (DUF2196)
AW22_RS01585	COG0745	RESPONSE REGULATOR receiver
AW22_RS01590	COG2205	protein histidine kinase activity
AW22_RS01595	COG1131	(ABC) transporter
AW22_RS01620	COG2318	DinB family
AW22_RS01640	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_RS01645	COG1309	transcriptional regulator
AW22_RS01650	COG1024	Enoyl-CoA hydratase
AW22_RS01655	COG2086	electron transfer activity
AW22_RS01660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AW22_RS01665	COG3118	belongs to the thioredoxin family
AW22_RS01675	COG1719	4-vinyl reductase, 4VR
AW22_RS01680	COG2009	succinate dehydrogenase
AW22_RS01685	COG1053	succinate dehydrogenase
AW22_RS01690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AW22_RS01695	COG0824	Thioesterase
AW22_RS01700	COG1876	peptidase activity
AW22_RS01705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AW22_RS01710	COG1360	Flagellar Motor Protein
AW22_RS01715	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AW22_RS01720	COG4152	abc transporter atp-binding protein
AW22_RS01725	COG1668	transmembrane transport
AW22_RS01730	COG1959	2 iron, 2 sulfur cluster binding
AW22_RS01740	COG0697	spore germination
AW22_RS01745	COG1396	sequence-specific DNA binding
AW22_RS01755	COG0402	S-adenosylhomocysteine deaminase activity
AW22_RS01760	COG2233	PERMEase
AW22_RS01765	COG2197	response regulator
AW22_RS01780	COG1309	transcriptional regulator
AW22_RS01800	COG5401	PFAM Sporulation and spore germination
AW22_RS01815	COG0622	Phosphoesterase
AW22_RS01860	COG0470	DNA polymerase III
AW22_RS01860	COG1067	ATP-dependent peptidase activity
AW22_RS01875	COG1764	response to oxidative stress
AW22_RS01880	COG1846	Transcriptional regulator
AW22_RS01890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AW22_RS01900	COG1587	Uroporphyrinogen-III synthase
AW22_RS01905	COG0113	porphobilinogen synthase activity
AW22_RS01915	COG1388	LysM domain
AW22_RS01930	COG0285	dihydrofolate synthase activity
AW22_RS01950	COG1077	Cell shape determining protein MreB Mrl
AW22_RS01970	COG2894	cell division
AW22_RS01975	COG0739	heme binding
AW22_RS01985	COG1530	ribonuclease E activity
AW22_RS01995	COG2868	ribosomal protein
AW22_RS02005	COG3290	protein histidine kinase activity
AW22_RS02015	COG0745	RESPONSE REGULATOR receiver
AW22_RS02020	COG5002	protein histidine kinase activity
AW22_RS02025	COG1136	(ABC) transporter
AW22_RS02030	COG0577	efflux transmembrane transporter activity
AW22_RS02035	COG0577	efflux transmembrane transporter activity
AW22_RS02040	COG0077	Prephenate dehydratase
AW22_RS02045	COG2258	MOSC domain
AW22_RS02050	COG1827	regulation of RNA biosynthetic process
AW22_RS02055	COG1104	cysteine desulfurase activity
AW22_RS02060	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AW22_RS02065	COG0157	Belongs to the NadC ModD family
AW22_RS02090	COG0640	Transcriptional regulator
AW22_RS02105	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AW22_RS02135	COG1862	Preprotein translocase
AW22_RS02145	COG2323	membrane
AW22_RS02150	COG2244	polysaccharide biosynthetic process
AW22_RS02160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AW22_RS02160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AW22_RS02165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AW22_RS02170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AW22_RS02170	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AW22_RS02180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AW22_RS02205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AW22_RS02220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AW22_RS02225	COG1959	2 iron, 2 sulfur cluster binding
AW22_RS02230	COG1104	cysteine desulfurase activity
AW22_RS02245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AW22_RS02265	COG0628	permease
AW22_RS02295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AW22_RS02300	COG4122	O-methyltransferase activity
AW22_RS02305	COG0826	peptidase U32
AW22_RS02310	COG0826	peptidase U32
AW22_RS02325	COG0768	penicillin binding
AW22_RS02350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AW22_RS02355	COG0626	cystathionine gamma-synthase activity
AW22_RS02360	COG1012	belongs to the aldehyde dehydrogenase family
AW22_RS02360	COG1454	alcohol dehydrogenase
AW22_RS02370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_RS02410	COG2259	Doxx family
AW22_RS02415	COG2514	catechol 2,3-dioxygenase activity
AW22_RS02425	COG3186	Phenylalanine-4-hydroxylase
AW22_RS02430	COG1404	Belongs to the peptidase S8 family
AW22_RS02465	COG2267	carboxylic ester hydrolase activity
AW22_RS02475	COG1785	Belongs to the alkaline phosphatase family
AW22_RS02485	COG2357	RelA SpoT domain protein
AW22_RS02490	COG0778	Nitroreductase
AW22_RS02500	COG1595	DNA-templated transcription, initiation
AW22_RS02525	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AW22_RS02530	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AW22_RS02540	COG1534	Rna-binding protein
AW22_RS02550	COG1713	HD superfamily hydrolase involved in NAD metabolism
AW22_RS02555	COG0799	negative regulation of ribosome biogenesis
AW22_RS02560	COG2226	methyltransferase
AW22_RS02565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AW22_RS02570	COG1555	photosystem II stabilization
AW22_RS02570	COG1596	polysaccharide export
AW22_RS02575	COG2131	deaminase
AW22_RS02580	COG0658	competence protein
AW22_RS02580	COG2333	competence protein COMEC
AW22_RS02590	COG1466	dna polymerase III delta subunit
AW22_RS02615	COG1733	regulation of RNA biosynthetic process
AW22_RS02620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AW22_RS02650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AW22_RS02655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AW22_RS02660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AW22_RS02665	COG1610	YqeY-like protein
AW22_RS02685	COG1702	phosphate starvation-inducible protein PhoH
AW22_RS02690	COG1480	7TM receptor with intracellular HD hydrolase
AW22_RS02700	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AW22_RS02705	COG0295	cytidine deaminase activity
AW22_RS02710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AW22_RS02725	COG0517	IMP dehydrogenase activity
AW22_RS02745	COG0358	DNA primase activity
AW22_RS02750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AW22_RS02755	COG2010	Cytochrome c
AW22_RS02760	COG2384	SAM-dependent methyltransferase
AW22_RS02765	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AW22_RS02795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_RS02800	COG1121	(ABC) transporter
AW22_RS02805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AW22_RS02810	COG0735	belongs to the Fur family
AW22_RS02835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AW22_RS02840	COG0477	Major facilitator Superfamily
AW22_RS02845	COG0768	penicillin binding
AW22_RS02850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AW22_RS02855	COG0573	inorganic phosphate transmembrane transporter activity
AW22_RS02860	COG0581	inorganic phosphate transmembrane transporter activity
AW22_RS02870	COG0704	Plays a role in the regulation of phosphate uptake
AW22_RS02875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AW22_RS02880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AW22_RS02885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AW22_RS02890	COG4483	Protein conserved in bacteria
AW22_RS02895	COG1940	carbohydrate kinase activity
AW22_RS02905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_RS02925	COG0626	cystathionine gamma-synthase activity
AW22_RS02930	COG0626	cystathionine gamma-synthase activity
AW22_RS02940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AW22_RS02940	COG0646	methionine synthase
AW22_RS02945	COG1410	methionine synthase
AW22_RS02945	COG0646	methionine synthase
AW22_RS02995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AW22_RS03000	COG1459	type II secretion system
AW22_RS03010	COG4970	Tfp pilus assembly protein FimT
AW22_RS03065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AW22_RS03095	COG1725	Transcriptional regulator
AW22_RS03100	COG1131	(ABC) transporter
AW22_RS03140	COG2076	Multidrug Resistance protein
AW22_RS03145	COG2076	Multidrug Resistance protein
AW22_RS03155	COG1609	Transcriptional regulator
AW22_RS03160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW22_RS03165	COG0095	Lipoate-protein ligase
AW22_RS03180	COG1695	Transcriptional regulator
AW22_RS03195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AW22_RS03205	COG3872	metal-dependent enzyme
AW22_RS03220	COG0006	proline dipeptidase activity
AW22_RS03245	COG3854	ATPases associated with a variety of cellular activities
AW22_RS03290	COG0511	ligase activity, forming carbon-carbon bonds
AW22_RS03295	COG0439	Biotin carboxylase
AW22_RS03300	COG1302	Protein conserved in bacteria
AW22_RS03325	COG0142	geranyltranstransferase activity
AW22_RS03335	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AW22_RS03345	COG0497	DNA recombination
AW22_RS03350	COG0750	zinc metalloprotease
AW22_RS03355	COG0745	RESPONSE REGULATOR receiver
AW22_RS03365	COG3093	addiction module antidote protein HigA
AW22_RS03370	COG0584	glycerophosphoryl diester phosphodiesterase
AW22_RS03380	COG3829	transcription factor binding
AW22_RS03380	COG3290	protein histidine kinase activity
AW22_RS03390	COG0280	phosphate acetyltransferase
AW22_RS03405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AW22_RS03410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AW22_RS03415	COG0022	dehydrogenase e1 component
AW22_RS03420	COG0508	dehydrogenase complex catalyzes the overall conversion of
AW22_RS03430	COG0772	Belongs to the SEDS family
AW22_RS03435	COG2816	NAD+ diphosphatase activity
AW22_RS03455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW22_RS03460	COG0765	amino acid transport
AW22_RS03465	COG1126	abc transporter atp-binding protein
AW22_RS03470	COG4129	membrane
AW22_RS03475	COG1376	ErfK ybiS ycfS ynhG family protein
AW22_RS03490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_RS03495	COG2195	Cleaves the N-terminal amino acid of tripeptides
AW22_RS03505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AW22_RS03525	COG1760	l-serine dehydratase
AW22_RS03530	COG1760	l-serine dehydratase
AW22_RS03535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AW22_RS03540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_RS03545	COG0300	oxidoreductase activity
AW22_RS03560	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AW22_RS03570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AW22_RS03590	COG1522	sequence-specific DNA binding
AW22_RS03600	COG0737	Belongs to the 5'-nucleotidase family
AW22_RS03605	COG1757	Na H antiporter
AW22_RS03615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AW22_RS03630	COG1073	alpha beta
AW22_RS03630	COG2226	methyltransferase
AW22_RS03635	COG4106	trans-aconitate 2-methyltransferase activity
AW22_RS03660	COG0307	riboflavin synthase, alpha
AW22_RS03665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AW22_RS03665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AW22_RS03680	COG1073	alpha beta
AW22_RS03685	COG0456	acetyltransferase
AW22_RS03690	COG1609	Transcriptional regulator
AW22_RS03695	COG2056	Na+-H+ antiporter family
AW22_RS03700	COG0596	Alpha beta hydrolase
AW22_RS03710	COG0737	Belongs to the 5'-nucleotidase family
AW22_RS03710	COG1525	nuclease
AW22_RS03710	COG4085	toxin activity
AW22_RS03720	COG0456	acetyltransferase
AW22_RS03720	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AW22_RS03725	COG0656	L-ascorbic acid biosynthetic process
AW22_RS03730	COG0667	Aldo Keto reductase
AW22_RS03750	COG1300	Membrane
AW22_RS03755	COG0735	belongs to the Fur family
AW22_RS03765	COG4974	Belongs to the 'phage' integrase family
AW22_RS03790	COG0598	Magnesium transport protein CorA
AW22_RS03805	COG1846	Transcriptional regulator
AW22_RS03825	COG1131	(ABC) transporter
AW22_RS03830	COG1725	Transcriptional regulator
AW22_RS03835	COG1686	Belongs to the peptidase S11 family
AW22_RS03855	COG0733	neurotransmitter:sodium symporter activity
AW22_RS03880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_RS03895	COG0697	spore germination
AW22_RS03900	COG0561	phosphatase activity
AW22_RS03905	COG4086	secreted protein
AW22_RS03910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AW22_RS03920	COG0456	acetyltransferase
AW22_RS03925	COG1547	Domain of unknown function (DUF309)
AW22_RS03955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AW22_RS03965	COG2188	Transcriptional regulator
AW22_RS03975	COG3711	transcriptional antiterminator
AW22_RS03980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_RS03980	COG2190	(PTS) system
AW22_RS03980	COG1263	PTS System
AW22_RS04005	COG0778	Nitroreductase
AW22_RS04010	COG2199	diguanylate cyclase activity
AW22_RS04015	COG2084	Dehydrogenase
AW22_RS04050	COG0436	Aminotransferase
AW22_RS04055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AW22_RS04075	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS04080	COG1695	Transcriptional regulator
AW22_RS04115	COG0183	Belongs to the thiolase family
AW22_RS04160	COG3842	ATPase activity
AW22_RS04165	COG0366	Alpha amylase catalytic
AW22_RS04175	COG2182	Extracellular solute-binding protein
AW22_RS04180	COG1175	transmembrane transport
AW22_RS04185	COG3833	ABC-type maltose transport systems, permease component
AW22_RS04190	COG1609	Transcriptional regulator
AW22_RS04195	COG0436	Aminotransferase
AW22_RS04205	COG2205	protein histidine kinase activity
AW22_RS04215	COG3209	COG3209 Rhs family protein
AW22_RS04240	COG2814	Major facilitator Superfamily
AW22_RS04280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AW22_RS04290	COG1408	metallophosphoesterase
AW22_RS04295	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS04300	COG2200	EAL domain
AW22_RS04315	COG4703	Protein of unknown function (DUF1797)
AW22_RS04325	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AW22_RS04335	COG0517	IMP dehydrogenase activity
AW22_RS04340	COG0583	DNA-binding transcription factor activity
AW22_RS04360	COG0569	domain protein
AW22_RS04365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AW22_RS04375	COG0561	phosphatase activity
AW22_RS04380	COG0242	peptide deformylase activity
AW22_RS04390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AW22_RS04395	COG0022	dehydrogenase e1 component
AW22_RS04445	COG1982	Orn Lys Arg decarboxylase major
AW22_RS04465	COG0483	inositol monophosphate 1-phosphatase activity
AW22_RS04475	COG1217	gtp-binding protein TYPA
AW22_RS04490	COG4896	Protein conserved in bacteria
AW22_RS04500	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AW22_RS04505	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AW22_RS04515	COG0772	Belongs to the SEDS family
AW22_RS04520	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AW22_RS04555	COG3336	cytochrome c oxidase
AW22_RS04570	COG2340	Cysteine-rich secretory protein family
AW22_RS04585	COG0406	alpha-ribazole phosphatase activity
AW22_RS04590	COG3679	Belongs to the UPF0342 family
AW22_RS04605	COG0742	ribosomal rna small subunit methyltransferase
AW22_RS04615	COG3314	Sporulation integral membrane protein YlbJ
AW22_RS04620	COG1752	Esterase of the alpha-beta hydrolase superfamily
AW22_RS04625	COG3480	Lon protease (S16) C-terminal proteolytic domain
AW22_RS04635	COG0582	viral genome integration into host DNA
AW22_RS04650	COG1396	sequence-specific DNA binding
AW22_RS04660	COG1396	sequence-specific DNA binding
AW22_RS04690	COG1484	DNA-dependent DNA replication
AW22_RS04760	COG0582	viral genome integration into host DNA
AW22_RS04795	COG1802	Transcriptional regulator
AW22_RS04795	COG4626	Terminase
AW22_RS04805	COG0740	serine-type endopeptidase activity
AW22_RS04875	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_RS04890	COG3708	Transcriptional regulator
AW22_RS04890	COG2207	Transcriptional regulator
AW22_RS04920	COG1399	metal-binding, possibly nucleic acid-binding protein
AW22_RS04925	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AW22_RS04940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AW22_RS04955	COG4839	cell division protein FtsL
AW22_RS04960	COG0768	penicillin binding
AW22_RS04965	COG0768	penicillin binding
AW22_RS04970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AW22_RS04985	COG0772	Belongs to the SEDS family
AW22_RS04995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AW22_RS05000	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AW22_RS05005	COG0849	cell division
AW22_RS05010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AW22_RS05020	COG1191	sigma factor activity
AW22_RS05025	COG1191	sigma factor activity
AW22_RS05030	COG1873	PFAM PRC-barrel domain
AW22_RS05035	COG1496	oxidoreductase activity
AW22_RS05040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AW22_RS05050	COG0762	integral membrane protein
AW22_RS05055	COG2302	S4 RNA-binding domain
AW22_RS05060	COG3599	regulation of cell shape
AW22_RS05080	COG0564	pseudouridine synthase activity
AW22_RS05140	COG3069	C4-dicarboxylate transmembrane transporter activity
AW22_RS05160	COG0006	proline dipeptidase activity
AW22_RS05170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AW22_RS05175	COG1561	YicC-like family, N-terminal region
AW22_RS05195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AW22_RS05200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AW22_RS05205	COG0242	peptide deformylase activity
AW22_RS05215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AW22_RS05215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AW22_RS05225	COG0631	protein serine/threonine phosphatase activity
AW22_RS05230	COG0515	serine threonine protein kinase
AW22_RS05230	COG2815	serine threonine protein kinase
AW22_RS05235	COG1162	GTPase activity
AW22_RS05240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AW22_RS05245	COG1564	THIamine pyrophosphokinase
AW22_RS05260	COG1302	Protein conserved in bacteria
AW22_RS05265	COG1461	Dihydroxyacetone kinase
AW22_RS05270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AW22_RS05285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AW22_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS05295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AW22_RS05305	COG1196	nuclear chromosome segregation
AW22_RS05310	COG0552	protein localization to endoplasmic reticulum
AW22_RS05320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AW22_RS05330	COG1837	Belongs to the UPF0109 family
AW22_RS05370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AW22_RS05375	COG0758	DNA mediated transformation
AW22_RS05380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AW22_RS05390	COG4974	Belongs to the 'phage' integrase family
AW22_RS05420	COG0528	UMP kinase activity
AW22_RS05435	COG4589	Belongs to the CDS family
AW22_RS05445	COG0750	zinc metalloprotease
AW22_RS05480	COG0195	Participates in both transcription termination and antitermination
AW22_RS05485	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AW22_RS05490	COG1358	cellular component organization or biogenesis
AW22_RS05500	COG1550	Protein conserved in bacteria
AW22_RS05530	COG0726	polysaccharide deacetylase
AW22_RS05535	COG0612	Peptidase, M16
AW22_RS05540	COG1873	PFAM PRC-barrel domain
AW22_RS05545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AW22_RS05550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AW22_RS05555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AW22_RS05560	COG0527	aspartate kinase activity
AW22_RS05575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AW22_RS05580	COG0740	serine-type endopeptidase activity
AW22_RS05590	COG1674	ftsk spoiiie
AW22_RS05595	COG2188	Transcriptional regulator
AW22_RS05600	COG1744	ABC transporter substrate-binding protein PnrA-like
AW22_RS05605	COG3845	ABC transporter
AW22_RS05610	COG4603	Belongs to the binding-protein-dependent transport system permease family
AW22_RS05615	COG1079	Belongs to the binding-protein-dependent transport system permease family
AW22_RS05620	COG0612	Peptidase, M16
AW22_RS05625	COG0612	Peptidase, M16
AW22_RS05630	COG0300	oxidoreductase activity
AW22_RS05645	COG1426	Protein conserved in bacteria
AW22_RS05650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AW22_RS05675	COG1692	metallophosphoesterase
AW22_RS05680	COG2359	stage V sporulation protein S
AW22_RS05690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AW22_RS05690	COG0674	pyruvate-flavodoxin oxidoreductase activity
AW22_RS05695	COG1013	pyruvate-flavodoxin oxidoreductase activity
AW22_RS05705	COG4550	Control of competence regulator ComK, YlbF/YmcA
AW22_RS05725	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AW22_RS05735	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AW22_RS05740	COG1368	sulfuric ester hydrolase activity
AW22_RS05750	COG3773	Cell wall hydrolase
AW22_RS05755	COG1404	Belongs to the peptidase S8 family
AW22_RS05770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_RS05825	COG5001	Diguanylate cyclase
AW22_RS05825	COG3300	MHYT domain
AW22_RS05830	COG0346	lactoylglutathione lyase activity
AW22_RS05835	COG2267	carboxylic ester hydrolase activity
AW22_RS05850	COG2364	Membrane
AW22_RS05860	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AW22_RS05865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AW22_RS05870	COG2169	Transcriptional regulator
AW22_RS05875	COG0708	Exodeoxyribonuclease III
AW22_RS05880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_RS05885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_RS05890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_RS05895	COG1120	ATPase activity
AW22_RS05900	COG2819	hydrolase of the alpha beta superfamily
AW22_RS05915	COG1937	Protein conserved in bacteria
AW22_RS05920	COG2608	mercury ion transmembrane transporter activity
AW22_RS05925	COG2217	Heavy metal translocating P-type atpase
AW22_RS05935	COG2116	formate transmembrane transporter activity
AW22_RS05940	COG1408	metallophosphoesterase
AW22_RS05950	COG1113	amino acid transport
AW22_RS05965	COG2322	membrane
AW22_RS05970	COG1979	alcohol dehydrogenase
AW22_RS05975	COG1349	DNA-binding transcription factor activity
AW22_RS05980	COG1105	Belongs to the carbohydrate kinase PfkB family
AW22_RS05985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW22_RS05985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AW22_RS05985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AW22_RS05990	COG1388	LysM domain
AW22_RS05990	COG3584	3D domain protein
AW22_RS06020	COG0464	growth
AW22_RS06030	COG2860	membrane
AW22_RS06035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AW22_RS06040	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AW22_RS06045	COG0789	Transcriptional regulator
AW22_RS06050	COG0174	glutamine synthetase
AW22_RS06055	COG1695	Transcriptional regulator
AW22_RS06075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AW22_RS06085	COG0737	Belongs to the 5'-nucleotidase family
AW22_RS06100	COG3639	organic phosphonate transmembrane transporter activity
AW22_RS06120	COG3763	UPF0154 protein
AW22_RS06215	COG1132	(ABC) transporter
AW22_RS06220	COG1132	(ABC) transporter
AW22_RS06235	COG3409	Peptidoglycan-binding domain 1 protein
AW22_RS06235	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_RS06245	COG0730	response to heat
AW22_RS06260	COG1346	cytolysis
AW22_RS06270	COG0583	DNA-binding transcription factor activity
AW22_RS06280	COG1131	(ABC) transporter
AW22_RS06290	COG1473	amidohydrolase
AW22_RS06300	COG0785	Cytochrome C biogenesis protein
AW22_RS06305	COG4846	Membrane protein involved in cytochrome C biogenesis
AW22_RS06320	COG3344	reverse transcriptase
AW22_RS06365	COG2226	methyltransferase
AW22_RS06390	COG0010	Belongs to the arginase family
AW22_RS06395	COG1329	Transcriptional regulator
AW22_RS06400	COG1902	pentaerythritol trinitrate reductase activity
AW22_RS06405	COG0069	glutamate synthase activity
AW22_RS06410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AW22_RS06415	COG0346	lactoylglutathione lyase activity
AW22_RS06420	COG0400	carboxylic ester hydrolase activity
AW22_RS06425	COG5002	protein histidine kinase activity
AW22_RS06435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_RS06485	COG1396	sequence-specific DNA binding
AW22_RS06495	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_RS06500	COG1268	BioY protein
AW22_RS06505	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_RS06510	COG0183	Belongs to the thiolase family
AW22_RS06525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AW22_RS06535	COG2211	Major facilitator Superfamily
AW22_RS06565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AW22_RS06570	COG1132	(ABC) transporter
AW22_RS06580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW22_RS06610	COG0824	Thioesterase
AW22_RS06615	COG4841	protein insertion into membrane
AW22_RS06635	COG0745	RESPONSE REGULATOR receiver
AW22_RS06640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AW22_RS06645	COG1832	CoA-binding protein
AW22_RS06655	COG0187	DNA topoisomerase II activity
AW22_RS06660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AW22_RS06665	COG0673	inositol 2-dehydrogenase activity
AW22_RS06675	COG1131	(ABC) transporter
AW22_RS06700	COG1595	DNA-templated transcription, initiation
AW22_RS06710	COG1316	TRANSCRIPTIONal
AW22_RS06715	COG1301	dicarboxylic acid transport
AW22_RS06720	COG4166	transmembrane transport
AW22_RS06725	COG4166	transmembrane transport
AW22_RS06735	COG4166	transmembrane transport
AW22_RS06740	COG2226	methyltransferase
AW22_RS06780	COG0697	spore germination
AW22_RS06790	COG3383	formate dehydrogenase (NAD+) activity
AW22_RS06795	COG2427	Protein of unknown function (DUF1641)
AW22_RS06800	COG5609	conserved protein (DUF2294)
AW22_RS06805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AW22_RS06815	COG2116	formate transmembrane transporter activity
AW22_RS06820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AW22_RS06825	COG0303	'Molybdopterin
AW22_RS06830	COG0314	molybdopterin synthase activity
AW22_RS06840	COG0489	protein tyrosine kinase activity
AW22_RS06855	COG3326	Membrane
AW22_RS06860	COG2962	Rard protein
AW22_RS06865	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AW22_RS06870	COG1657	PFAM Prenyltransferase squalene oxidase
AW22_RS06880	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS06885	COG1012	belongs to the aldehyde dehydrogenase family
AW22_RS06895	COG4145	pantothenate transmembrane transporter activity
AW22_RS06910	COG0165	Argininosuccinate lyase
AW22_RS06920	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS06950	COG0716	FMN binding
AW22_RS06990	COG2720	vancomycin resistance protein
AW22_RS06995	COG2514	catechol 2,3-dioxygenase activity
AW22_RS07005	COG1285	pathogenesis
AW22_RS07015	COG1024	Enoyl-CoA hydratase
AW22_RS07020	COG1216	Glycosyl transferase, family 2
AW22_RS07055	COG0277	FAD linked oxidase domain protein
AW22_RS07060	COG0385	Bile acid
AW22_RS07075	COG2808	Putative FMN-binding domain
AW22_RS07080	COG0457	Tetratricopeptide repeat
AW22_RS07090	COG0604	alcohol dehydrogenase
AW22_RS07095	COG0640	Transcriptional regulator
AW22_RS07120	COG0584	glycerophosphoryl diester phosphodiesterase
AW22_RS07150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AW22_RS07155	COG1164	Oligoendopeptidase f
AW22_RS07160	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AW22_RS07180	COG1193	negative regulation of DNA recombination
AW22_RS07200	COG0583	DNA-binding transcription factor activity
AW22_RS07220	COG0384	phenazine biosynthesis protein PhzF
AW22_RS07225	COG3739	integral membrane protein
AW22_RS07230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_RS07235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_RS07240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_RS07255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AW22_RS07260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AW22_RS07290	COG2814	Major facilitator Superfamily
AW22_RS07295	COG1113	amino acid transport
AW22_RS07340	COG2072	flavoprotein involved in K transport
AW22_RS07375	COG3409	Peptidoglycan-binding domain 1 protein
AW22_RS07375	COG3757	hydrolase, family 25
AW22_RS07380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_RS07395	COG1151	hydroxylamine reductase activity
AW22_RS07435	COG1309	transcriptional regulator
AW22_RS07440	COG1266	CAAX protease self-immunity
AW22_RS07445	COG1191	sigma factor activity
AW22_RS07465	COG1733	regulation of RNA biosynthetic process
AW22_RS07470	COG2249	NAD(P)H dehydrogenase (quinone) activity
AW22_RS07475	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_RS07490	COG0384	phenazine biosynthesis protein PhzF
AW22_RS07525	COG0673	inositol 2-dehydrogenase activity
AW22_RS07530	COG2188	Transcriptional regulator
AW22_RS07540	COG1393	Belongs to the ArsC family
AW22_RS07565	COG0814	amino acid
AW22_RS07600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AW22_RS07610	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AW22_RS07615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AW22_RS07625	COG1070	Carbohydrate kinase
AW22_RS07630	COG2706	6-phosphogluconolactonase activity
AW22_RS07635	COG3813	Protein conserved in bacteria
AW22_RS07640	COG1357	PFAM Pentapeptide repeats (8 copies)
AW22_RS07645	COG0697	spore germination
AW22_RS07650	COG0789	Transcriptional regulator
AW22_RS07655	COG1253	flavin adenine dinucleotide binding
AW22_RS07685	COG0477	Major facilitator Superfamily
AW22_RS07695	COG2226	methyltransferase
AW22_RS07715	COG0628	permease
AW22_RS07730	COG0577	efflux transmembrane transporter activity
AW22_RS07730	COG1136	(ABC) transporter
AW22_RS07740	COG0110	maltose O-acetyltransferase activity
AW22_RS07745	COG1940	carbohydrate kinase activity
AW22_RS07750	COG0346	lactoylglutathione lyase activity
AW22_RS07775	COG2365	Tyrosine phosphatase family
AW22_RS07800	COG1011	Hydrolase
AW22_RS07840	COG1131	(ABC) transporter
AW22_RS07850	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS07870	COG0469	pyruvate kinase activity
AW22_RS07880	COG0778	Nitroreductase
AW22_RS07885	COG1733	regulation of RNA biosynthetic process
AW22_RS07905	COG2197	response regulator
AW22_RS07915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AW22_RS07920	COG2356	endonuclease I
AW22_RS07925	COG1288	antiporter activity
AW22_RS07945	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AW22_RS07980	COG2249	NAD(P)H dehydrogenase (quinone) activity
AW22_RS07990	COG2031	fatty acid transporter
AW22_RS08010	COG1309	transcriptional regulator
AW22_RS08015	COG2076	Multidrug Resistance protein
AW22_RS08035	COG1131	(ABC) transporter
AW22_RS08040	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AW22_RS08055	COG2814	Major facilitator Superfamily
AW22_RS08060	COG1846	Transcriptional regulator
AW22_RS08070	COG0477	Major facilitator Superfamily
AW22_RS08110	COG2814	Major facilitator Superfamily
AW22_RS08125	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_RS08125	COG3409	Peptidoglycan-binding domain 1 protein
AW22_RS08155	COG2207	Transcriptional regulator
AW22_RS08155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_RS08165	COG0662	Cupin 2, conserved barrel domain protein
AW22_RS08180	COG1595	DNA-templated transcription, initiation
AW22_RS08200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AW22_RS08215	COG1619	proteins homologs of microcin C7 resistance protein MccF
AW22_RS08235	COG0583	DNA-binding transcription factor activity
AW22_RS08245	COG1139	Iron-sulfur cluster binding protein
AW22_RS08250	COG1556	Lactate utilization protein
AW22_RS08255	COG2271	Major facilitator Superfamily
AW22_RS08260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_RS08265	COG2808	Putative FMN-binding domain
AW22_RS08270	COG0456	acetyltransferase
AW22_RS08275	COG1846	Transcriptional regulator
AW22_RS08280	COG2364	Membrane
AW22_RS08290	COG5002	protein histidine kinase activity
AW22_RS08290	COG3850	Histidine kinase
AW22_RS08310	COG0577	efflux transmembrane transporter activity
AW22_RS08330	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AW22_RS08335	COG0789	Transcriptional regulator
AW22_RS08345	COG2309	aminopeptidase activity
AW22_RS08360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_RS08370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW22_RS08375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_RS08405	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AW22_RS08435	COG3850	Histidine kinase
AW22_RS08435	COG5002	protein histidine kinase activity
AW22_RS08440	COG0745	RESPONSE REGULATOR receiver
AW22_RS08465	COG2814	Major facilitator Superfamily
AW22_RS08505	COG0346	lactoylglutathione lyase activity
AW22_RS08525	COG0443	Heat shock 70 kDa protein
AW22_RS08540	COG0640	Transcriptional regulator
AW22_RS08545	COG0346	lactoylglutathione lyase activity
AW22_RS08550	COG0798	PFAM Bile acid sodium symporter
AW22_RS08580	COG1121	(ABC) transporter
AW22_RS08585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AW22_RS08590	COG0803	Belongs to the bacterial solute-binding protein 9 family
AW22_RS08595	COG2267	carboxylic ester hydrolase activity
AW22_RS08600	COG1575	Belongs to the MenA family. Type 1 subfamily
AW22_RS08605	COG0714	Associated with various cellular activities
AW22_RS08620	COG5609	conserved protein (DUF2294)
AW22_RS08625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AW22_RS08635	COG0288	reversible hydration of carbon dioxide
AW22_RS08670	COG0657	acetylesterase activity
AW22_RS08675	COG1309	transcriptional regulator
AW22_RS08680	COG2124	cytochrome p450
AW22_RS08690	COG1063	alcohol dehydrogenase
AW22_RS08715	COG0598	Magnesium transport protein CorA
AW22_RS08725	COG2329	Antibiotic biosynthesis monooxygenase
AW22_RS08730	COG0737	Belongs to the 5'-nucleotidase family
AW22_RS08745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AW22_RS08760	COG1063	alcohol dehydrogenase
AW22_RS08790	COG1113	amino acid transport
AW22_RS08795	COG1280	lysine exporter protein (LysE YggA)
AW22_RS08800	COG3403	YqcI/YcgG family
AW22_RS08805	COG5577	PFAM Coat F domain
AW22_RS08820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_RS08830	COG3848	Pyruvate phosphate dikinase
AW22_RS08830	COG0574	Belongs to the PEP-utilizing enzyme family
AW22_RS08855	COG3314	Sporulation integral membrane protein YlbJ
AW22_RS08870	COG1960	acyl-CoA dehydrogenase activity
AW22_RS08880	COG0640	Transcriptional regulator
AW22_RS08885	COG0860	N-Acetylmuramoyl-L-alanine amidase
AW22_RS08890	COG3142	Participates in the control of copper homeostasis
AW22_RS08900	COG1414	Transcriptional regulator
AW22_RS08905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AW22_RS08910	COG1984	allophanate hydrolase subunit 2
AW22_RS08940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AW22_RS08945	COG0768	penicillin binding
AW22_RS08975	COG4335	DNA alkylation repair
AW22_RS08985	COG0833	amino acid
AW22_RS08995	COG0730	response to heat
AW22_RS09025	COG0596	Alpha beta hydrolase
AW22_RS09030	COG0745	RESPONSE REGULATOR receiver
AW22_RS09035	COG0642	Histidine kinase
AW22_RS09060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_RS09080	COG0456	acetyltransferase
AW22_RS09085	COG2207	Transcriptional regulator
AW22_RS09110	COG0577	efflux transmembrane transporter activity
AW22_RS09110	COG1136	(ABC) transporter
AW22_RS09125	COG1725	Transcriptional regulator
AW22_RS09160	COG1846	Transcriptional regulator
AW22_RS09165	COG0778	Nitroreductase
AW22_RS09195	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AW22_RS09205	COG0753	catalase activity
AW22_RS09210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AW22_RS09220	COG0463	Glycosyl transferase, family 2
AW22_RS09270	COG0714	Associated with various cellular activities
AW22_RS09295	COG0346	lactoylglutathione lyase activity
AW22_RS09300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_RS09325	COG3279	Response regulator of the LytR AlgR family
AW22_RS09335	COG4377	Putative membrane peptidase family (DUF2324)
AW22_RS09350	COG3655	Transcriptional regulator
AW22_RS09360	COG1785	Belongs to the alkaline phosphatase family
AW22_RS09365	COG3239	Fatty acid desaturase
AW22_RS09370	COG1690	Belongs to the RtcB family
AW22_RS09375	COG0833	amino acid
AW22_RS09380	COG1414	Transcriptional regulator
AW22_RS09385	COG4187	Peptidase family M20/M25/M40
AW22_RS09390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AW22_RS09395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AW22_RS09405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_RS09425	COG2329	Antibiotic biosynthesis monooxygenase
AW22_RS09460	COG1070	Carbohydrate kinase
AW22_RS09465	COG2390	Transcriptional regulator
AW22_RS09475	COG1172	Belongs to the binding-protein-dependent transport system permease family
AW22_RS09485	COG1879	ABC-type sugar transport system periplasmic component
AW22_RS09500	COG3829	transcription factor binding
AW22_RS09500	COG3290	protein histidine kinase activity
AW22_RS09510	COG1024	Enoyl-CoA hydratase
AW22_RS09515	COG2610	gluconate transmembrane transporter activity
AW22_RS09525	COG3584	3D domain protein
AW22_RS09525	COG1388	LysM domain
AW22_RS09560	COG1605	Chorismate mutase
AW22_RS09560	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AW22_RS09570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AW22_RS09575	COG0287	Prephenate dehydrogenase
AW22_RS09590	COG1309	transcriptional regulator
AW22_RS09595	COG2409	Drug exporters of the RND superfamily
AW22_RS09595	COG1033	growth of symbiont in host cell
AW22_RS09605	COG0488	(ABC) transporter
AW22_RS09610	COG1368	sulfuric ester hydrolase activity
AW22_RS09615	COG0861	Integral membrane protein TerC family
AW22_RS09655	COG2318	DinB family
AW22_RS09660	COG0697	spore germination
AW22_RS09685	COG2746	aminoglycoside 3-N-acetyltransferase activity
AW22_RS09705	COG2816	NAD+ diphosphatase activity
AW22_RS09715	COG1116	anion transmembrane transporter activity
AW22_RS09720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AW22_RS09725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AW22_RS09730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AW22_RS09745	COG0628	permease
AW22_RS09795	COG1131	(ABC) transporter
AW22_RS09810	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AW22_RS09815	COG5146	pantothenate kinase activity
AW22_RS09820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AW22_RS09825	COG0436	Aminotransferase
AW22_RS09855	COG2226	methyltransferase
AW22_RS09870	COG2261	transglycosylase associated protein
AW22_RS09890	COG0477	Major facilitator Superfamily
AW22_RS09890	COG2814	Major facilitator Superfamily
AW22_RS09895	COG4533	DNA binding
AW22_RS09900	COG0789	Transcriptional regulator
AW22_RS09905	COG1664	Polymer-forming cytoskeletal
AW22_RS09915	COG2814	Major facilitator Superfamily
AW22_RS09950	COG1307	EDD domain protein, DegV family
AW22_RS09955	COG1522	sequence-specific DNA binding
AW22_RS09960	COG0531	amino acid
AW22_RS09965	COG1164	Oligoendopeptidase f
AW22_RS09995	COG0745	RESPONSE REGULATOR receiver
AW22_RS10000	COG5002	protein histidine kinase activity
AW22_RS10005	COG2936	dipeptidyl-peptidase activity
AW22_RS10045	COG4948	Mandelate Racemase Muconate Lactonizing
AW22_RS10055	COG4166	transmembrane transport
AW22_RS10060	COG0519	Catalyzes the synthesis of GMP from XMP
AW22_RS10065	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AW22_RS10080	COG0586	Pfam SNARE associated Golgi protein
AW22_RS10120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AW22_RS10125	COG3938	Belongs to the proline racemase family
AW22_RS10135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AW22_RS10140	COG1012	belongs to the aldehyde dehydrogenase family
AW22_RS10145	COG1115	amino acid carrier protein
AW22_RS10150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AW22_RS10160	COG3397	chitin binding
AW22_RS10185	COG4637	Psort location Cytoplasmic, score
AW22_RS10215	COG0514	ATP-dependent DNA helicase (RecQ)
AW22_RS10220	COG2105	PFAM AIG2 family protein
AW22_RS10235	COG3973	AAA domain
AW22_RS10285	COG0658	competence protein
AW22_RS10285	COG2333	competence protein COMEC
AW22_RS10290	COG2153	protein acetylation
AW22_RS10295	COG2315	Protein conserved in bacteria
AW22_RS10300	COG2226	methyltransferase
AW22_RS10305	COG2205	protein histidine kinase activity
AW22_RS10315	COG3397	chitin binding
AW22_RS10320	COG2153	protein acetylation
AW22_RS10350	COG4175	Glycine betaine
AW22_RS10350	COG0517	IMP dehydrogenase activity
AW22_RS10355	COG4176	ABC-type proline glycine betaine transport system permease component
AW22_RS10380	COG0494	nUDIX hydrolase
AW22_RS10390	COG0572	uridine kinase
AW22_RS10395	COG0456	acetyltransferase
AW22_RS10395	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AW22_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS10410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AW22_RS10415	COG0022	dehydrogenase e1 component
AW22_RS10420	COG0508	dehydrogenase complex catalyzes the overall conversion of
AW22_RS10425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AW22_RS10440	COG1959	2 iron, 2 sulfur cluster binding
AW22_RS10460	COG1349	DNA-binding transcription factor activity
AW22_RS10480	COG3284	Transcriptional regulator
AW22_RS10505	COG1309	transcriptional regulator
AW22_RS10540	COG2959	enzyme of heme biosynthesis
AW22_RS10555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_RS10590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_RS10595	COG0697	spore germination
AW22_RS10605	COG0201	protein transport
AW22_RS10610	COG0346	lactoylglutathione lyase activity
AW22_RS10630	COG3227	Zinc metalloprotease (Elastase)
AW22_RS10635	COG1523	belongs to the glycosyl hydrolase 13 family
AW22_RS10655	COG1011	Hydrolase
AW22_RS10680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AW22_RS10715	COG0322	excinuclease ABC activity
AW22_RS10730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AW22_RS10755	COG4667	esterase of the alpha-beta hydrolase superfamily
AW22_RS10780	COG3878	Protein conserved in bacteria
AW22_RS10790	COG0406	alpha-ribazole phosphatase activity
AW22_RS10815	COG1051	belongs to the nudix hydrolase family
AW22_RS10820	COG0592	DNA-directed DNA polymerase activity
AW22_RS10825	COG2816	NAD+ diphosphatase activity
AW22_RS10830	COG2223	nitrite transmembrane transporter activity
AW22_RS10840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AW22_RS10865	COG0697	spore germination
AW22_RS10870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_RS10890	COG0584	glycerophosphoryl diester phosphodiesterase
AW22_RS10905	COG2814	Major facilitator Superfamily
AW22_RS10925	COG0693	protein deglycase activity
AW22_RS10960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AW22_RS10970	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS10980	COG0768	penicillin binding
AW22_RS10985	COG0671	phosphoesterase, PA-phosphatase related
AW22_RS10990	COG0604	alcohol dehydrogenase
AW22_RS10995	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AW22_RS11005	COG2205	protein histidine kinase activity
AW22_RS11025	COG1794	racemase activity, acting on amino acids and derivatives
AW22_RS11030	COG1819	glycosyl
AW22_RS11035	COG0768	penicillin binding
AW22_RS11040	COG5002	protein histidine kinase activity
AW22_RS11045	COG0561	phosphatase activity
AW22_RS11080	COG2124	cytochrome p450
AW22_RS11170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AW22_RS11180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_RS11185	COG0460	homoserine dehydrogenase
AW22_RS11205	COG0577	efflux transmembrane transporter activity
AW22_RS11210	COG1136	(ABC) transporter
AW22_RS11225	COG0488	(ABC) transporter
AW22_RS11235	COG2205	protein histidine kinase activity
AW22_RS11240	COG0745	RESPONSE REGULATOR receiver
AW22_RS11250	COG3773	Cell wall hydrolase
AW22_RS11255	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AW22_RS11265	COG3386	PFAM SMP-30 Gluconolaconase
AW22_RS11285	COG1063	alcohol dehydrogenase
AW22_RS11305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_RS11345	COG2814	Major facilitator Superfamily
AW22_RS11370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AW22_RS11370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AW22_RS11390	COG3227	Zinc metalloprotease (Elastase)
AW22_RS11410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AW22_RS11435	COG1686	Belongs to the peptidase S11 family
AW22_RS11440	COG2318	DinB family
AW22_RS11450	COG0572	uridine kinase
AW22_RS11455	COG1247	-acetyltransferase
AW22_RS11465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AW22_RS11470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AW22_RS11475	COG1024	Enoyl-CoA hydratase
AW22_RS11480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AW22_RS11485	COG0511	ligase activity, forming carbon-carbon bonds
AW22_RS11490	COG0439	Biotin carboxylase
AW22_RS11495	COG1960	acyl-CoA dehydrogenase activity
AW22_RS11515	COG0675	Transposase, IS605 OrfB family
AW22_RS11520	COG1408	metallophosphoesterase
AW22_RS11525	COG2367	Beta-lactamase
AW22_RS11530	COG0768	penicillin binding
AW22_RS11535	COG0768	penicillin binding
AW22_RS11545	COG1595	DNA-templated transcription, initiation
AW22_RS11560	COG2195	Cleaves the N-terminal amino acid of tripeptides
AW22_RS11595	COG1846	Transcriptional regulator
AW22_RS11600	COG3961	Belongs to the TPP enzyme family
AW22_RS11675	COG0582	viral genome integration into host DNA
AW22_RS11690	COG3615	Tellurite resistance protein tehB
AW22_RS11690	COG0500	methyltransferase
AW22_RS11695	COG0577	efflux transmembrane transporter activity
AW22_RS11695	COG1136	(ABC) transporter
AW22_RS11710	COG1309	transcriptional regulator
AW22_RS11740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_RS11780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AW22_RS11790	COG2971	BadF BadG BcrA BcrD
AW22_RS11815	COG1649	PFAM Uncharacterised BCR, COG1649
AW22_RS11840	COG1595	DNA-templated transcription, initiation
AW22_RS11845	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AW22_RS11855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AW22_RS11885	COG1396	sequence-specific DNA binding
AW22_RS11905	COG1132	(ABC) transporter
AW22_RS11910	COG1132	(ABC) transporter
AW22_RS11925	COG2258	MOSC domain
AW22_RS11930	COG0583	DNA-binding transcription factor activity
AW22_RS11945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AW22_RS11950	COG0583	DNA-binding transcription factor activity
AW22_RS11960	COG0010	Belongs to the arginase family
AW22_RS12165	COG0515	serine threonine protein kinase
AW22_RS12165	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AW22_RS12180	COG2002	toxin-antitoxin pair type II binding
AW22_RS12250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW22_RS12250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW22_RS12255	COG0592	DNA-directed DNA polymerase activity
AW22_RS12355	COG1278	Cold shock
AW22_RS12365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_RS12370	COG2226	methyltransferase
AW22_RS12380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AW22_RS12410	COG1247	-acetyltransferase
AW22_RS12445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_RS12490	COG2226	methyltransferase
AW22_RS12515	COG0596	Alpha beta hydrolase
AW22_RS12525	COG1136	(ABC) transporter
AW22_RS12535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AW22_RS12540	COG1187	pseudouridine synthase activity
AW22_RS12545	COG2329	Antibiotic biosynthesis monooxygenase
AW22_RS12560	COG1115	amino acid carrier protein
AW22_RS12570	COG2318	DinB family
AW22_RS12580	COG0776	regulation of translation
AW22_RS12595	COG2814	Major facilitator Superfamily
AW22_RS12600	COG3251	PFAM MbtH domain protein
AW22_RS12605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AW22_RS12610	COG3433	isochorismatase activity
AW22_RS12610	COG1535	isochorismatase
AW22_RS12615	COG1021	2,3-dihydroxybenzoate-AMP ligase
AW22_RS12620	COG1169	isochorismate synthase
AW22_RS12625	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS12630	COG2223	nitrite transmembrane transporter activity
AW22_RS12660	COG0420	3'-5' exonuclease activity
AW22_RS12675	COG1024	Enoyl-CoA hydratase
AW22_RS12680	COG1280	lysine exporter protein (LysE YggA)
AW22_RS12690	COG2084	Dehydrogenase
AW22_RS12695	COG1960	acyl-CoA dehydrogenase activity
AW22_RS12700	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AW22_RS12705	COG2079	MmgE PrpD family protein
AW22_RS12710	COG0372	Belongs to the citrate synthase family
AW22_RS12715	COG4841	protein insertion into membrane
AW22_RS12720	COG2814	Major facilitator Superfamily
AW22_RS12730	COG4499	WXG100 protein secretion system (Wss), protein YukC
AW22_RS12730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW22_RS12750	COG0300	oxidoreductase activity
AW22_RS12785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AW22_RS12850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW22_RS12855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AW22_RS12860	COG0671	phosphoesterase, PA-phosphatase related
AW22_RS12865	COG4326	sporulation control protein
AW22_RS12870	COG4991	sh3 domain protein
AW22_RS12870	COG0515	serine threonine protein kinase
AW22_RS12870	COG3064	Membrane
AW22_RS12905	COG1509	lysine 2,3-aminomutase activity
AW22_RS12910	COG3829	transcription factor binding
AW22_RS12915	COG0456	acetyltransferase
AW22_RS12920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AW22_RS12925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AW22_RS12930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AW22_RS12935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AW22_RS12950	COG5506	Protein of unknown function (DUF1694)
AW22_RS12955	COG1012	belongs to the aldehyde dehydrogenase family
AW22_RS12960	COG1253	flavin adenine dinucleotide binding
AW22_RS12995	COG1174	glycine betaine transport
AW22_RS13000	COG0517	IMP dehydrogenase activity
AW22_RS13000	COG1125	glycine betaine transport
AW22_RS13030	COG1070	Carbohydrate kinase
AW22_RS13035	COG1070	Carbohydrate kinase
AW22_RS13060	COG1064	alcohol dehydrogenase
AW22_RS13065	COG1737	Transcriptional regulator
AW22_RS13070	COG2197	response regulator
AW22_RS13075	COG4585	Histidine kinase
AW22_RS13075	COG2203	Gaf domain
AW22_RS13080	COG0668	transmembrane transport
AW22_RS13090	COG1051	belongs to the nudix hydrolase family
AW22_RS13095	COG1335	isochorismatase
AW22_RS13115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AW22_RS13120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_RS13140	COG0367	asparagine synthase
AW22_RS13145	COG0071	Belongs to the small heat shock protein (HSP20) family
AW22_RS13150	COG1999	signal sequence binding
AW22_RS13155	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AW22_RS13160	COG1307	EDD domain protein, DegV family
AW22_RS13170	COG0805	protein transport
AW22_RS13180	COG1272	protein, Hemolysin III
AW22_RS13185	COG0204	Acyl-transferase
AW22_RS13195	COG0768	penicillin binding
AW22_RS13210	COG3250	beta-galactosidase activity
AW22_RS13215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AW22_RS13235	COG0546	phosphoglycolate phosphatase activity
AW22_RS13245	COG4473	ABC transporter
AW22_RS13250	COG1131	(ABC) transporter
AW22_RS13260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AW22_RS13265	COG0456	acetyltransferase
AW22_RS13275	COG1794	racemase activity, acting on amino acids and derivatives
AW22_RS13280	COG1454	alcohol dehydrogenase
AW22_RS13285	COG2610	gluconate transmembrane transporter activity
AW22_RS13310	COG0733	neurotransmitter:sodium symporter activity
AW22_RS13325	COG5002	protein histidine kinase activity
AW22_RS13325	COG3850	Histidine kinase
AW22_RS13330	COG0745	RESPONSE REGULATOR receiver
AW22_RS13335	COG0471	metal ion transport
AW22_RS13340	COG1929	Belongs to the glycerate kinase type-1 family
AW22_RS13495	COG1674	ftsk spoiiie
AW22_RS13515	COG0017	Asparaginyl-tRNA synthetase
AW22_RS13520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AW22_RS13560	COG2136	Putative SAM-dependent methyltransferase
AW22_RS13560	COG2521	methyltransferase
AW22_RS13575	COG1413	lyase activity
AW22_RS13590	COG0629	single-stranded DNA binding
AW22_RS13605	COG0488	(ABC) transporter
AW22_RS13610	COG1418	mRNA catabolic process
AW22_RS13675	COG2359	stage V sporulation protein S
AW22_RS13710	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AW22_RS13715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AW22_RS13720	COG2146	nitrite reductase [NAD(P)H] activity
AW22_RS13725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AW22_RS13725	COG1587	Uroporphyrinogen-III synthase
AW22_RS13735	COG1648	precorrin-2 dehydrogenase activity
AW22_RS13745	COG2223	nitrite transmembrane transporter activity
AW22_RS13755	COG0314	molybdopterin synthase activity
AW22_RS13760	COG0303	'Molybdopterin
AW22_RS13765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AW22_RS13770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AW22_RS13775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AW22_RS13780	COG2181	nitrate reductase activity
AW22_RS13785	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AW22_RS13790	COG1140	nitrate reductase beta subunit
AW22_RS13795	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AW22_RS13810	COG0714	Associated with various cellular activities
AW22_RS13815	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AW22_RS13820	COG1305	Transglutaminase-like
AW22_RS13825	COG0386	Belongs to the glutathione peroxidase family
AW22_RS13835	COG0426	domain, Protein
AW22_RS13835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AW22_RS13850	COG1595	DNA-templated transcription, initiation
AW22_RS13865	COG0346	lactoylglutathione lyase activity
AW22_RS13870	COG1082	Xylose isomerase domain protein TIM barrel
AW22_RS13890	COG2226	methyltransferase
AW22_RS13915	COG3874	Sporulation protein YtfJ
AW22_RS13990	COG0456	acetyltransferase
AW22_RS14020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_RS14025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_RS14030	COG1819	glycosyl
AW22_RS14045	COG4106	trans-aconitate 2-methyltransferase activity
AW22_RS14050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AW22_RS14060	COG0561	phosphatase activity
AW22_RS14070	COG1942	4-Oxalocrotonate Tautomerase
AW22_RS14090	COG3971	2-oxopent-4-enoate hydratase activity
AW22_RS14100	COG0251	oxidation-reduction process
AW22_RS14115	COG0196	riboflavin kinase activity
AW22_RS14125	COG2368	4-hydroxyphenylacetate
AW22_RS14140	COG2211	Major facilitator Superfamily
AW22_RS14145	COG0154	amidase activity
AW22_RS14155	COG1876	peptidase activity
AW22_RS14165	COG0860	N-Acetylmuramoyl-L-alanine amidase
AW22_RS14185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AW22_RS14190	COG1114	Component of the transport system for branched-chain amino acids
AW22_RS14205	COG1253	flavin adenine dinucleotide binding
AW22_RS14210	COG2839	Protein conserved in bacteria
AW22_RS14215	COG0702	epimerase
AW22_RS14230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW22_RS14235	COG1607	acyl-coa hydrolase
AW22_RS14240	COG3689	TIGRFAM TIGR03943 family protein
AW22_RS14245	COG0701	Predicted permease
AW22_RS14255	COG2244	polysaccharide biosynthetic process
AW22_RS14260	COG0586	Pfam SNARE associated Golgi protein
AW22_RS14265	COG1051	belongs to the nudix hydrolase family
AW22_RS14270	COG5337	Spore coat protein CotH
AW22_RS14280	COG0406	alpha-ribazole phosphatase activity
AW22_RS14295	COG4166	transmembrane transport
AW22_RS14305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AW22_RS14315	COG0702	epimerase
AW22_RS14325	COG3443	Belongs to the bacterial solute-binding protein 9 family
AW22_RS14325	COG0803	Belongs to the bacterial solute-binding protein 9 family
AW22_RS14345	COG0456	acetyltransferase
AW22_RS14350	COG0523	cobalamin synthesis protein
AW22_RS14355	COG4989	oxidoreductase activity
AW22_RS14365	COG1231	oxidoreductase activity
AW22_RS14375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AW22_RS14390	COG0783	Belongs to the Dps family
AW22_RS14395	COG3949	Membrane
AW22_RS14415	COG0840	transmembrane signaling receptor activity
AW22_RS14440	COG2814	Major facilitator Superfamily
AW22_RS14445	COG0667	Aldo Keto reductase
AW22_RS14450	COG0640	Transcriptional regulator
AW22_RS14455	COG1404	Belongs to the peptidase S8 family
AW22_RS14460	COG2002	toxin-antitoxin pair type II binding
AW22_RS14465	COG0577	efflux transmembrane transporter activity
AW22_RS14500	COG1752	Esterase of the alpha-beta hydrolase superfamily
AW22_RS14510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_RS14515	COG1279	arginine transmembrane transporter activity
AW22_RS14520	COG2814	Major facilitator Superfamily
AW22_RS14530	COG1082	Xylose isomerase domain protein TIM barrel
AW22_RS14540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AW22_RS14560	COG1247	-acetyltransferase
AW22_RS14565	COG1285	pathogenesis
AW22_RS14580	COG5002	protein histidine kinase activity
AW22_RS14585	COG0745	RESPONSE REGULATOR receiver
AW22_RS14595	COG1316	TRANSCRIPTIONal
AW22_RS14620	COG0460	homoserine dehydrogenase
AW22_RS14650	COG4122	O-methyltransferase activity
AW22_RS14655	COG0300	oxidoreductase activity
AW22_RS14665	COG5002	protein histidine kinase activity
AW22_RS14670	COG0745	RESPONSE REGULATOR receiver
AW22_RS14675	COG1132	(ABC) transporter
AW22_RS14685	COG1388	LysM domain
AW22_RS14685	COG0791	NLP P60 protein
AW22_RS14700	COG1686	Belongs to the peptidase S11 family
AW22_RS14715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AW22_RS14720	COG4988	ABC transporter
AW22_RS14725	COG1294	oxidase, subunit
AW22_RS14730	COG1271	oxidase subunit
AW22_RS14750	COG1942	4-Oxalocrotonate Tautomerase
AW22_RS14760	COG0583	DNA-binding transcription factor activity
AW22_RS14780	COG0411	ABC transporter
AW22_RS14790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_RS14795	COG2030	dehydratase
AW22_RS14800	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_RS14815	COG0523	cobalamin synthesis protein
AW22_RS14820	COG1231	oxidoreductase activity
AW22_RS14830	COG0628	permease
AW22_RS14845	COG0778	Nitroreductase
AW22_RS14850	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AW22_RS14855	COG1959	2 iron, 2 sulfur cluster binding
AW22_RS14860	COG0583	DNA-binding transcription factor activity
AW22_RS14865	COG0697	spore germination
AW22_RS14875	COG4549	nuclear export factor GLE1
AW22_RS14880	COG1276	copper resistance
AW22_RS14880	COG2372	response to copper ion
AW22_RS14890	COG1114	Component of the transport system for branched-chain amino acids
AW22_RS14910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AW22_RS14940	COG0464	growth
AW22_RS14950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AW22_RS14955	COG0076	glutamate decarboxylase activity
AW22_RS14965	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AW22_RS15005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AW22_RS15020	COG2132	Multicopper oxidase
AW22_RS15025	COG0006	proline dipeptidase activity
AW22_RS15045	COG4846	Membrane protein involved in cytochrome C biogenesis
AW22_RS15055	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AW22_RS15060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_RS15070	COG2390	Transcriptional regulator
AW22_RS15075	COG2205	protein histidine kinase activity
AW22_RS15080	COG0745	RESPONSE REGULATOR receiver
AW22_RS15125	COG0531	amino acid
AW22_RS15135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AW22_RS15150	COG1914	H( )-stimulated, divalent metal cation uptake system
AW22_RS15175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_RS15180	COG0535	radical SAM domain protein
AW22_RS15205	COG4166	transmembrane transport
AW22_RS15240	COG0427	acetyl-CoA hydrolase
AW22_RS15245	COG3279	Response regulator of the LytR AlgR family
AW22_RS15265	COG3384	dioxygenase
AW22_RS15270	COG2814	Major facilitator Superfamily
AW22_RS15295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AW22_RS15305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AW22_RS15315	COG0028	Belongs to the TPP enzyme family
AW22_RS15320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AW22_RS15330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AW22_RS15345	COG2084	Dehydrogenase
AW22_RS15360	COG2323	membrane
AW22_RS15365	COG5566	PFAM Mor transcription activator
AW22_RS15375	COG0733	neurotransmitter:sodium symporter activity
AW22_RS15380	COG2244	polysaccharide biosynthetic process
AW22_RS15395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AW22_RS15400	COG2223	nitrite transmembrane transporter activity
AW22_RS15405	COG4166	transmembrane transport
AW22_RS15410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AW22_RS15420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_RS15425	COG0477	Major facilitator Superfamily
AW22_RS15435	COG1966	Carbon starvation protein
AW22_RS15460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_RS15475	COG1051	belongs to the nudix hydrolase family
AW22_RS15540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AW22_RS15545	COG0784	Response regulator, receiver
AW22_RS15550	COG4191	Histidine kinase
AW22_RS15555	COG0281	malic enzyme
AW22_RS15560	COG1027	Aspartate ammonia-lyase
AW22_RS15570	COG0528	UMP kinase activity
AW22_RS15575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW22_RS15590	COG1131	(ABC) transporter
AW22_RS15625	COG2733	membrane
AW22_RS15655	COG0785	Cytochrome C biogenesis protein
AW22_RS15675	COG3340	Belongs to the peptidase S51 family
AW22_RS15680	COG0534	Mate efflux family protein
AW22_RS15700	COG0114	fumarate hydratase activity
AW22_RS15705	COG1757	Na H antiporter
AW22_RS15720	COG0701	Predicted permease
AW22_RS15725	COG0523	cobalamin synthesis protein
AW22_RS15730	COG0697	spore germination
AW22_RS15735	COG1802	Transcriptional regulator
AW22_RS15765	COG0367	asparagine synthase
AW22_RS15775	COG1846	Transcriptional regulator
AW22_RS15790	COG0406	alpha-ribazole phosphatase activity
AW22_RS15800	COG1686	Belongs to the peptidase S11 family
AW22_RS15840	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS15855	COG1234	tRNA 3'-trailer cleavage
AW22_RS15870	COG3842	ATPase activity
AW22_RS15875	COG0583	DNA-binding transcription factor activity
AW22_RS15900	COG2329	Antibiotic biosynthesis monooxygenase
AW22_RS15955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AW22_RS15960	COG4786	Flagellar basal body rod
AW22_RS15965	COG1419	protein localization to endoplasmic reticulum
AW22_RS15970	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AW22_RS15975	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AW22_RS15985	COG1987	bacterial-type flagellum assembly
AW22_RS15990	COG1338	Plays a role in the flagellum-specific transport system
AW22_RS16000	COG1776	CheC inhibitor of MCP methylation
AW22_RS16000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AW22_RS16005	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AW22_RS16015	COG0741	lytic transglycosylase activity
AW22_RS16020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AW22_RS16025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AW22_RS16035	COG0784	Response regulator, receiver
AW22_RS16035	COG0835	chemotaxis
AW22_RS16050	COG1749	Flagellar hook protein flgE
AW22_RS16070	COG1157	protein secretion by the type III secretion system
AW22_RS16080	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AW22_RS16085	COG1766	The M ring may be actively involved in energy transduction
AW22_RS16095	COG1558	bacterial-type flagellum-dependent cell motility
AW22_RS16100	COG1815	bacterial-type flagellum-dependent cell motility
AW22_RS16120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AW22_RS16125	COG1256	bacterial-type flagellum assembly
AW22_RS16145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AW22_RS16160	COG1776	CheC inhibitor of MCP methylation
AW22_RS16160	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AW22_RS16165	COG0643	Histidine kinase
AW22_RS16165	COG2198	Histidine kinase
AW22_RS16170	COG2201	protein-glutamate methylesterase activity
AW22_RS16175	COG1360	Flagellar Motor Protein
AW22_RS16180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AW22_RS16190	COG1923	regulation of RNA biosynthetic process
AW22_RS16245	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AW22_RS16250	COG2323	membrane
AW22_RS16260	COG0789	Transcriptional regulator
AW22_RS16260	COG4978	Transcriptional regulator
AW22_RS16265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AW22_RS16270	COG0475	glutathione-regulated potassium exporter activity
AW22_RS16280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AW22_RS16285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AW22_RS16290	COG3162	membrane
AW22_RS16305	COG1280	lysine exporter protein (LysE YggA)
AW22_RS16310	COG3403	YqcI/YcgG family
AW22_RS16345	COG0328	RNA-DNA hybrid ribonuclease activity
AW22_RS16365	COG0454	-acetyltransferase
AW22_RS16430	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_RS16505	COG4626	Terminase
AW22_RS16505	COG1802	Transcriptional regulator
AW22_RS16615	COG1396	sequence-specific DNA binding
AW22_RS16615	COG3800	Transcriptional regulator
AW22_RS16635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW22_RS16650	COG0754	glutathionylspermidine amidase activity
AW22_RS16680	COG0456	acetyltransferase
AW22_RS16690	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AW22_RS16695	COG2311	Membrane
AW22_RS16700	COG2233	PERMEase
AW22_RS16710	COG0024	Methionine aminopeptidase
AW22_RS16715	COG3173	Aminoglycoside phosphotransferase
AW22_RS16725	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AW22_RS16730	COG1199	ATP-dependent helicase activity
AW22_RS16740	COG0116	Belongs to the methyltransferase superfamily
AW22_RS16790	COG4499	WXG100 protein secretion system (Wss), protein YukC
AW22_RS16790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW22_RS16800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AW22_RS16805	COG3935	DnaD domain protein
AW22_RS16825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AW22_RS16825	COG1199	ATP-dependent helicase activity
AW22_RS16865	COG0438	transferase activity, transferring glycosyl groups
AW22_RS16870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AW22_RS16885	COG1694	Mazg nucleotide pyrophosphohydrolase
AW22_RS16895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_RS16905	COG2738	Putative neutral zinc metallopeptidase
AW22_RS16920	COG4347	Protein of unknown function (DUF1405)
AW22_RS16930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AW22_RS16950	COG0457	Tetratricopeptide repeat
AW22_RS16955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AW22_RS16975	COG0142	geranyltranstransferase activity
AW22_RS16985	COG0142	geranyltranstransferase activity
AW22_RS17000	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AW22_RS17070	COG0252	asparaginase activity
AW22_RS17075	COG0492	ferredoxin-NADP+ reductase activity
AW22_RS17095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AW22_RS17100	COG4862	establishment of competence for transformation
AW22_RS17110	COG1408	metallophosphoesterase
AW22_RS17120	COG1266	CAAX protease self-immunity
AW22_RS17125	COG0514	ATP-dependent DNA helicase (RecQ)
AW22_RS17135	COG1141	Ferredoxin
AW22_RS17140	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AW22_RS17150	COG4942	peptidase
AW22_RS17155	COG2096	Adenosyltransferase
AW22_RS17160	COG5002	protein histidine kinase activity
AW22_RS17165	COG0745	RESPONSE REGULATOR receiver
AW22_RS17170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AW22_RS17175	COG1333	cytochrome c biogenesis protein
AW22_RS17185	COG1187	pseudouridine synthase activity
AW22_RS17190	COG0700	Nucleoside recognition
AW22_RS17195	COG2715	membrane protein required for spore maturation
AW22_RS17200	COG1686	Belongs to the peptidase S11 family
AW22_RS17205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AW22_RS17220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AW22_RS17220	COG0392	lysyltransferase activity
AW22_RS17240	COG5002	protein histidine kinase activity
AW22_RS17245	COG0582	viral genome integration into host DNA
AW22_RS17255	COG1801	Protein of unknown function DUF72
AW22_RS17260	COG3852	Histidine kinase
AW22_RS17275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW22_RS17280	COG1392	Phosphate transport regulator
AW22_RS17285	COG0306	phosphate transporter
AW22_RS17290	COG0730	response to heat
AW22_RS17335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AW22_RS17345	COG1114	Component of the transport system for branched-chain amino acids
AW22_RS17355	COG2197	response regulator
AW22_RS17360	COG4585	Histidine kinase
AW22_RS17365	COG4758	membrane
AW22_RS17380	COG1757	Na H antiporter
AW22_RS17400	COG0733	neurotransmitter:sodium symporter activity
AW22_RS17410	COG1648	precorrin-2 dehydrogenase activity
AW22_RS17430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AW22_RS17435	COG0529	Catalyzes the synthesis of activated sulfate
AW22_RS17455	COG0019	diaminopimelate decarboxylase activity
AW22_RS17465	COG1368	sulfuric ester hydrolase activity
AW22_RS17470	COG1183	phosphatidylcholine synthase activity
AW22_RS17475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AW22_RS17485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AW22_RS17560	COG0440	acetolactate synthase activity
AW22_RS17565	COG0028	Belongs to the TPP enzyme family
AW22_RS17570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AW22_RS17600	COG3874	Sporulation protein YtfJ
AW22_RS17605	COG4709	membrane
AW22_RS17610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AW22_RS17615	COG1301	dicarboxylic acid transport
AW22_RS17625	COG1846	Transcriptional regulator
AW22_RS17640	COG1968	undecaprenyl-diphosphatase activity
AW22_RS17645	COG0534	Mate efflux family protein
AW22_RS17680	COG0716	FMN binding
AW22_RS17705	COG1696	Membrane protein involved in D-alanine export
AW22_RS17715	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AW22_RS17720	COG2070	2-Nitropropane dioxygenase
AW22_RS17725	COG1619	proteins homologs of microcin C7 resistance protein MccF
AW22_RS17735	COG1335	isochorismatase
AW22_RS17745	COG1522	sequence-specific DNA binding
AW22_RS17760	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AW22_RS17765	COG1131	(ABC) transporter
AW22_RS17775	COG1131	(ABC) transporter
AW22_RS17780	COG1725	Transcriptional regulator
AW22_RS17785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AW22_RS17790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AW22_RS17790	COG1372	Participates in initiation and elongation during chromosome replication
AW22_RS17795	COG1403	HNH endonuclease
AW22_RS17800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AW22_RS17805	COG1780	Probably involved in ribonucleotide reductase function
AW22_RS17845	COG4873	Protein conserved in bacteria
AW22_RS17860	COG0720	synthase
AW22_RS17870	COG5002	protein histidine kinase activity
AW22_RS17880	COG2318	DinB family
AW22_RS17890	COG1846	Transcriptional regulator
AW22_RS17895	COG3852	Histidine kinase
AW22_RS17905	COG2861	carbohydrate metabolic process
AW22_RS17915	COG0235	Class ii aldolase
AW22_RS17930	COG1349	DNA-binding transcription factor activity
AW22_RS17955	COG3842	ATPase activity
AW22_RS17960	COG1840	ABC-type Fe3 transport system, periplasmic component
AW22_RS17975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AW22_RS17980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AW22_RS17985	COG3243	poly(R)-hydroxyalkanoic acid synthase
AW22_RS17990	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS18010	COG2030	dehydratase
AW22_RS18020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AW22_RS18025	COG0861	Integral membrane protein TerC family
AW22_RS18030	COG2116	formate transmembrane transporter activity
AW22_RS18040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AW22_RS18060	COG2186	Transcriptional regulator
AW22_RS18065	COG5002	protein histidine kinase activity
AW22_RS18070	COG0745	RESPONSE REGULATOR receiver
AW22_RS18080	COG3835	regulator
AW22_RS18085	COG0277	FAD linked oxidase domain protein
AW22_RS18090	COG0247	lactate metabolic process
AW22_RS18095	COG2340	Cysteine-rich secretory protein family
AW22_RS18105	COG0564	pseudouridine synthase activity
AW22_RS18115	COG2409	Drug exporters of the RND superfamily
AW22_RS18125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AW22_RS18130	COG1177	transmembrane transport
AW22_RS18135	COG1176	ABC-type spermidine putrescine transport system, permease component I
AW22_RS18145	COG1012	belongs to the aldehyde dehydrogenase family
AW22_RS18180	COG0681	Belongs to the peptidase S26 family
AW22_RS18185	COG1686	Belongs to the peptidase S11 family
AW22_RS18210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AW22_RS18220	COG5293	efflux transmembrane transporter activity
AW22_RS18280	COG1476	TRANSCRIPTIONal
AW22_RS18290	COG0508	dehydrogenase complex catalyzes the overall conversion of
AW22_RS18310	COG2226	methyltransferase
AW22_RS18345	COG5634	Uncharacterized conserved protein (DUF2278)
AW22_RS18350	COG1620	l-lactate permease
AW22_RS18385	COG0512	Glutamine amidotransferase of anthranilate synthase
AW22_RS18385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AW22_RS18400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AW22_RS18405	COG5492	domain, Protein
AW22_RS18420	COG2382	esterase
AW22_RS18430	COG2153	protein acetylation
AW22_RS18480	COG1091	dTDP-4-dehydrorhamnose reductase activity
AW22_RS18495	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AW22_RS18515	COG0457	Tetratricopeptide repeat
AW22_RS18515	COG0463	Glycosyl transferase, family 2
AW22_RS18535	COG1216	Glycosyl transferase, family 2
AW22_RS18540	COG0772	Belongs to the SEDS family
AW22_RS18555	COG0564	pseudouridine synthase activity
AW22_RS18565	COG2357	RelA SpoT domain protein
AW22_RS18575	COG4116	CYTH
AW22_RS18580	COG2346	COG2346, Truncated hemoglobins
AW22_RS18595	COG1164	Oligoendopeptidase f
AW22_RS18605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW22_RS18610	COG4862	establishment of competence for transformation
AW22_RS18615	COG0861	Integral membrane protein TerC family
AW22_RS18635	COG4166	transmembrane transport
AW22_RS18640	COG0534	Mate efflux family protein
AW22_RS18645	COG4608	Belongs to the ABC transporter superfamily
AW22_RS18650	COG0444	Belongs to the ABC transporter superfamily
AW22_RS18655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AW22_RS18660	COG0601	transmembrane transport
AW22_RS18665	COG4166	transmembrane transport
AW22_RS18675	COG0180	Tryptophanyl-tRNA synthetase
AW22_RS18685	COG5504	Zn-dependent protease
AW22_RS18690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AW22_RS18695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_RS18710	COG2267	carboxylic ester hydrolase activity
AW22_RS18720	COG0542	response to heat
AW22_RS18735	COG0561	phosphatase activity
AW22_RS18750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_RS18760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AW22_RS18770	COG2996	Protein conserved in bacteria
AW22_RS18795	COG0004	ammonium transporteR
AW22_RS18800	COG0753	catalase activity
AW22_RS18805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AW22_RS18810	COG0367	asparagine synthase
AW22_RS18835	COG0179	Fumarylacetoacetate (FAA) hydrolase
AW22_RS18895	COG0398	Pfam SNARE associated Golgi protein
AW22_RS18900	COG4903	ComK protein
AW22_RS18925	COG2224	Isocitrate lyase
AW22_RS18930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AW22_RS18950	COG0697	spore germination
AW22_RS18955	COG0501	Belongs to the peptidase M48B family
AW22_RS18980	COG0745	RESPONSE REGULATOR receiver
AW22_RS18985	COG2205	protein histidine kinase activity
AW22_RS18990	COG2207	Transcriptional regulator
AW22_RS18990	COG3708	Transcriptional regulator
AW22_RS18995	COG1595	DNA-templated transcription, initiation
AW22_RS19005	COG1078	dGTPase activity
AW22_RS19015	COG1408	metallophosphoesterase
AW22_RS19020	COG1073	alpha beta
AW22_RS19085	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_RS19095	COG0095	Lipoate-protein ligase
AW22_RS19100	COG1234	tRNA 3'-trailer cleavage
AW22_RS19110	COG1609	Transcriptional regulator
AW22_RS19135	COG1511	domain protein
AW22_RS19140	COG1309	transcriptional regulator
AW22_RS19180	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AW22_RS19195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW22_RS19200	COG2329	Antibiotic biosynthesis monooxygenase
AW22_RS19205	COG3428	Bacterial PH domain
AW22_RS19210	COG3402	PFAM membrane-flanked domain
AW22_RS19265	COG3428	Bacterial PH domain
AW22_RS19270	COG3402	PFAM membrane-flanked domain
AW22_RS19280	COG1309	transcriptional regulator
AW22_RS19345	COG4473	ABC transporter
AW22_RS19350	COG1131	(ABC) transporter
AW22_RS19355	COG0537	adenosine 5'-monophosphoramidase activity
AW22_RS19360	COG4980	gas vesicle protein
AW22_RS19385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AW22_RS19390	COG3973	AAA domain
AW22_RS19400	COG0477	Major facilitator Superfamily
AW22_RS19405	COG0477	Major facilitator Superfamily
AW22_RS19450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AW22_RS19460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AW22_RS19465	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AW22_RS19485	COG2267	carboxylic ester hydrolase activity
AW22_RS19495	COG0457	Tetratricopeptide repeat
AW22_RS19505	COG0346	lactoylglutathione lyase activity
AW22_RS19510	COG0346	lactoylglutathione lyase activity
AW22_RS19540	COG4717	serine-type aminopeptidase activity
AW22_RS19545	COG0420	3'-5' exonuclease activity
AW22_RS19570	COG2197	response regulator
AW22_RS19575	COG4585	Histidine kinase
AW22_RS19620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW22_RS19620	COG2198	Histidine kinase
AW22_RS19620	COG0784	Response regulator, receiver
AW22_RS19620	COG2205	protein histidine kinase activity
AW22_RS19625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AW22_RS19630	COG2208	phosphoserine phosphatase activity
AW22_RS19640	COG1191	sigma factor activity
AW22_RS19720	COG0457	Tetratricopeptide repeat
AW22_RS19735	COG1959	2 iron, 2 sulfur cluster binding
AW22_RS19740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AW22_RS19755	COG2376	Dihydroxyacetone kinase
AW22_RS19810	COG1183	phosphatidylcholine synthase activity
AW22_RS19825	COG1309	transcriptional regulator
AW22_RS19830	COG3320	Male sterility
AW22_RS19830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AW22_RS19920	COG1401	restriction endodeoxyribonuclease activity
AW22_RS19930	COG0305	Participates in initiation and elongation during chromosome replication
AW22_RS19945	COG0789	Transcriptional regulator
AW22_RS19945	COG4978	Transcriptional regulator
AW22_RS19990	COG3181	Tripartite tricarboxylate transporter family receptor
AW22_RS19995	COG4565	transcriptional regulatory protein
AW22_RS20000	COG3290	protein histidine kinase activity
AW22_RS20005	COG0477	Major facilitator Superfamily
AW22_RS20020	COG3938	Belongs to the proline racemase family
AW22_RS20040	COG1363	Peptidase, m42
AW22_RS20060	COG1024	Enoyl-CoA hydratase
AW22_RS20080	COG4196	transglutaminase domain protein
AW22_RS20085	COG0860	N-Acetylmuramoyl-L-alanine amidase
AW22_RS20095	COG2244	polysaccharide biosynthetic process
AW22_RS20125	COG0659	secondary active sulfate transmembrane transporter activity
AW22_RS20140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AW22_RS20145	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_RS20145	COG3409	Peptidoglycan-binding domain 1 protein
AW22_RS20150	COG0561	phosphatase activity
AW22_RS20160	COG3527	Alpha-acetolactate decarboxylase
AW22_RS20165	COG0028	Belongs to the TPP enzyme family
AW22_RS20210	COG4585	Histidine kinase
AW22_RS20235	COG0189	ligase activity
AW22_RS20250	COG1126	abc transporter atp-binding protein
AW22_RS20255	COG0765	amino acid transport
AW22_RS20260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW22_RS20265	COG1132	(ABC) transporter
AW22_RS20270	COG1132	(ABC) transporter
AW22_RS20280	COG1012	belongs to the aldehyde dehydrogenase family
AW22_RS20295	COG0531	amino acid
AW22_RS20305	COG0753	catalase activity
AW22_RS20305	COG0693	protein deglycase activity
AW22_RS20320	COG2211	Major facilitator Superfamily
AW22_RS20325	COG4533	DNA binding
AW22_RS20330	COG2814	Major facilitator Superfamily
AW22_RS20335	COG1309	transcriptional regulator
AW22_RS20340	COG2076	Multidrug Resistance protein
AW22_RS20355	COG1522	sequence-specific DNA binding
AW22_RS20375	COG2259	Doxx family
AW22_RS20390	COG1263	PTS System
AW22_RS20390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_RS20400	COG1737	Transcriptional regulator
AW22_RS20410	COG0475	glutathione-regulated potassium exporter activity
AW22_RS20415	COG0531	amino acid
AW22_RS20450	COG0586	Pfam SNARE associated Golgi protein
AW22_RS20485	COG3546	catalase activity
AW22_RS20490	COG1114	Component of the transport system for branched-chain amino acids
AW22_RS20495	COG0577	efflux transmembrane transporter activity
AW22_RS20510	COG5522	Integral membrane protein (intg_mem_TP0381)
AW22_RS20520	COG1136	(ABC) transporter
AW22_RS20525	COG0577	efflux transmembrane transporter activity
AW22_RS20530	COG3584	3D domain protein
AW22_RS20530	COG1388	LysM domain
AW22_RS20550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AW22_RS20555	COG1447	Phosphotransferase system cellobiose-specific component IIA
AW22_RS20560	COG3711	transcriptional antiterminator
AW22_RS20560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW22_RS20575	COG1283	sodium-dependent phosphate transmembrane transporter activity
AW22_RS20580	COG0604	alcohol dehydrogenase
AW22_RS20585	COG1316	TRANSCRIPTIONal
AW22_RS20595	COG0730	response to heat
AW22_RS20600	COG2210	Belongs to the sulfur carrier protein TusA family
AW22_RS20610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW22_RS20615	COG0425	Belongs to the sulfur carrier protein TusA family
AW22_RS20620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_RS20620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW22_RS20625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW22_RS20625	COG0425	Belongs to the sulfur carrier protein TusA family
AW22_RS20630	COG1937	Protein conserved in bacteria
AW22_RS20635	COG0446	pyridine nucleotide-disulphide oxidoreductase
AW22_RS20680	COG2719	SpoVR family
AW22_RS20685	COG0778	Nitroreductase
AW22_RS20725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW22_RS20735	COG1609	Transcriptional regulator
AW22_RS20740	COG1263	PTS System
AW22_RS20740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_RS20745	COG1621	beta-fructofuranosidase activity
AW22_RS20750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AW22_RS20765	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS20770	COG2252	PERMEase
AW22_RS20780	COG0577	efflux transmembrane transporter activity
AW22_RS20780	COG1136	(ABC) transporter
AW22_RS20805	COG1846	Transcriptional regulator
AW22_RS20810	COG2814	Major facilitator Superfamily
AW22_RS20815	COG2205	protein histidine kinase activity
AW22_RS20860	COG0351	phosphomethylpyrimidine kinase
AW22_RS20865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AW22_RS20875	COG2104	thiamine diphosphate biosynthetic process
AW22_RS20880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AW22_RS20885	COG0352	thiamine-phosphate diphosphorylase activity
AW22_RS20890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AW22_RS20900	COG1116	anion transmembrane transporter activity
AW22_RS20905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AW22_RS20930	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AW22_RS21050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AW22_RS21060	COG0581	inorganic phosphate transmembrane transporter activity
AW22_RS21065	COG0573	inorganic phosphate transmembrane transporter activity
AW22_RS21070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AW22_RS21075	COG1918	ferrous iron import across plasma membrane
AW22_RS21075	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AW22_RS21080	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AW22_RS21085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AW22_RS21100	COG0531	amino acid
AW22_RS21105	COG0697	spore germination
AW22_RS21110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AW22_RS21125	COG4990	cell redox homeostasis
AW22_RS21135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AW22_RS21140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AW22_RS21155	COG0475	glutathione-regulated potassium exporter activity
AW22_RS21155	COG0569	domain protein
AW22_RS21165	COG2153	protein acetylation
AW22_RS21185	COG2252	PERMEase
AW22_RS21190	COG1113	amino acid transport
AW22_RS21205	COG1114	Component of the transport system for branched-chain amino acids
AW22_RS21210	COG3104	oligopeptide transport
AW22_RS21225	COG1476	TRANSCRIPTIONal
AW22_RS21230	COG3584	3D domain protein
AW22_RS21230	COG1388	LysM domain
AW22_RS21235	COG0840	transmembrane signaling receptor activity
AW22_RS21265	COG3568	Endonuclease Exonuclease Phosphatase
AW22_RS21280	COG1063	alcohol dehydrogenase
AW22_RS21300	COG1879	ABC-type sugar transport system periplasmic component
AW22_RS21305	COG1172	Belongs to the binding-protein-dependent transport system permease family
AW22_RS21320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AW22_RS21325	COG1609	Transcriptional regulator
AW22_RS21330	COG0477	Major facilitator Superfamily
AW22_RS21335	COG1846	Transcriptional regulator
AW22_RS21340	COG2271	Major facilitator Superfamily
AW22_RS21350	COG4608	Belongs to the ABC transporter superfamily
AW22_RS21355	COG0601	transmembrane transport
AW22_RS21365	COG0747	negative chemotaxis
AW22_RS21380	COG0659	secondary active sulfate transmembrane transporter activity
AW22_RS21395	COG5002	protein histidine kinase activity
AW22_RS21400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AW22_RS21405	COG2378	regulation of single-species biofilm formation
AW22_RS21430	COG0833	amino acid
AW22_RS21435	COG0765	amino acid transport
AW22_RS21440	COG0765	amino acid transport
AW22_RS21445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW22_RS21450	COG1126	abc transporter atp-binding protein
AW22_RS21455	COG1115	amino acid carrier protein
AW22_RS21460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AW22_RS21475	COG1404	Belongs to the peptidase S8 family
AW22_RS21480	COG2197	response regulator
AW22_RS21485	COG4585	Histidine kinase
AW22_RS21490	COG0697	spore germination
AW22_RS21505	COG0366	Alpha amylase catalytic
AW22_RS21510	COG1263	PTS System
AW22_RS21510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_RS21515	COG2188	Transcriptional regulator
AW22_RS21520	COG0531	amino acid
AW22_RS21535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW22_RS21540	COG0714	Associated with various cellular activities
AW22_RS21545	COG4548	von Willebrand factor, type A
AW22_RS21555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AW22_RS21560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW22_RS21565	COG0156	8-amino-7-oxononanoate synthase activity
AW22_RS21570	COG2226	methyltransferase
AW22_RS21580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_RS21585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_RS21590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_RS21595	COG3104	oligopeptide transport
AW22_RS21610	COG1620	l-lactate permease
AW22_RS21615	COG1027	Aspartate ammonia-lyase
AW22_RS21620	COG1253	flavin adenine dinucleotide binding
AW22_RS21625	COG0346	lactoylglutathione lyase activity
AW22_RS21630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_RS21635	COG1316	TRANSCRIPTIONal
AW22_RS21640	COG2720	vancomycin resistance protein
AW22_RS21660	COG3227	Zinc metalloprotease (Elastase)
AW22_RS21670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AW22_RS21675	COG2217	Heavy metal translocating P-type atpase
AW22_RS21680	COG0640	Transcriptional regulator
AW22_RS21685	COG0531	amino acid
AW22_RS21700	COG2427	Protein of unknown function (DUF1641)
AW22_RS21705	COG3383	formate dehydrogenase (NAD+) activity
AW22_RS21710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AW22_RS21715	COG0456	acetyltransferase
AW22_RS21715	COG0454	-acetyltransferase
AW22_RS21725	COG0745	RESPONSE REGULATOR receiver
AW22_RS21730	COG5002	protein histidine kinase activity
AW22_RS21740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_RS21755	COG0281	malic enzyme
AW22_RS21760	COG3493	citrate carrier protein
AW22_RS21765	COG4565	transcriptional regulatory protein
AW22_RS21770	COG3290	protein histidine kinase activity
AW22_RS21780	COG4990	cell redox homeostasis
AW22_RS21790	COG5002	protein histidine kinase activity
AW22_RS21795	COG0745	RESPONSE REGULATOR receiver
AW22_RS21800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AW22_RS21810	COG0395	ABC-type sugar transport system, permease component
AW22_RS21815	COG1175	transmembrane transport
AW22_RS21820	COG3842	ATPase activity
AW22_RS21825	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AW22_RS21845	COG2851	Citrate transporter
AW22_RS21850	COG4565	transcriptional regulatory protein
AW22_RS21855	COG3290	protein histidine kinase activity
AW22_RS21865	COG2268	Band 7 protein
AW22_RS21870	COG1585	Membrane protein implicated in regulation of membrane protease activity
AW22_RS21880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AW22_RS21900	COG2766	serine protein kinase
AW22_RS21910	COG1716	ATPase activity
AW22_RS21910	COG5001	Diguanylate cyclase
AW22_RS21915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AW22_RS21925	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AW22_RS21935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AW22_RS21940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AW22_RS22105	COG0735	belongs to the Fur family
AW22_RS22110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AW22_RS22130	COG4555	ABC transporter
AW22_RS22140	COG0069	glutamate synthase activity
AW22_RS22140	COG0070	glutamate synthase
AW22_RS22140	COG0067	glutamate synthase
AW22_RS22145	COG4129	membrane
AW22_RS22150	COG1132	(ABC) transporter
AW22_RS22175	COG1194	a g-specific adenine glycosylase
AW22_RS22180	COG1988	membrane-bound metal-dependent
AW22_RS22210	COG1090	epimerase
AW22_RS22215	COG1228	amidohydrolase
AW22_RS22235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AW22_RS22255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AW22_RS22255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW22_RS22285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AW22_RS22290	COG1263	PTS System
AW22_RS22290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_RS22325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AW22_RS22355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AW22_RS22375	COG0535	radical SAM domain protein
AW22_RS22385	COG0387	Pfam Sodium calcium exchanger
AW22_RS22390	COG3871	stress protein (general stress protein 26)
AW22_RS22405	COG0586	Pfam SNARE associated Golgi protein
AW22_RS22425	COG0697	spore germination
AW22_RS22430	COG2217	Heavy metal translocating P-type atpase
AW22_RS22435	COG1295	ribonuclease BN
AW22_RS22445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AW22_RS22460	COG3853	Toxic anion resistance protein (TelA)
AW22_RS22470	COG0861	Integral membrane protein TerC family
AW22_RS22475	COG2310	stress, protein
AW22_RS22480	COG2310	stress, protein
AW22_RS22485	COG2310	stress, protein
AW22_RS22515	COG2270	Major facilitator Superfamily
AW22_RS22565	COG0488	(ABC) transporter
AW22_RS22575	COG1116	anion transmembrane transporter activity
AW22_RS22585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AW22_RS22600	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AW22_RS22630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_RS22630	COG1263	PTS System
AW22_RS22630	COG2190	(PTS) system
AW22_RS22640	COG0840	transmembrane signaling receptor activity
AW22_RS22645	COG0840	transmembrane signaling receptor activity
AW22_RS22655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW22_RS22660	COG0765	amino acid transport
AW22_RS22690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AW22_RS22690	COG0723	plastoquinol--plastocyanin reductase activity
AW22_RS22695	COG2814	Major facilitator Superfamily
AW22_RS22700	COG3541	Predicted nucleotidyltransferase
AW22_RS22720	COG5002	protein histidine kinase activity
AW22_RS22750	COG0166	Belongs to the GPI family
AW22_RS22770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_RS22775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_RS22780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_RS22805	COG0450	alkyl hydroperoxide reductase
AW22_RS22820	COG1473	amidohydrolase
AW22_RS22825	COG1757	Na H antiporter
AW22_RS22850	COG4807	Protein conserved in bacteria
AW22_RS22855	COG5002	protein histidine kinase activity
AW22_RS22860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AW22_RS22865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AW22_RS22870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_RS22885	COG2309	aminopeptidase activity
AW22_RS22890	COG2076	Multidrug Resistance protein
AW22_RS22895	COG1012	belongs to the aldehyde dehydrogenase family
AW22_RS22905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AW22_RS22910	COG0546	phosphoglycolate phosphatase activity
AW22_RS22915	COG1597	lipid kinase activity
AW22_RS22935	COG4682	membrane
AW22_RS22940	COG1846	Transcriptional regulator
AW22_RS22945	COG0003	Pfam Anion-transporting ATPase
AW22_RS22960	COG1464	Belongs to the NlpA lipoprotein family
AW22_RS22965	COG2011	ABC-type metal ion transport system permease component
AW22_RS22970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AW22_RS22975	COG1335	isochorismatase
AW22_RS22995	COG4851	CamS sex pheromone cAM373 precursor
AW22_RS23005	COG0210	DNA helicase
AW22_RS23035	COG0151	Belongs to the GarS family
AW22_RS23045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AW22_RS23055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AW22_RS23070	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AW22_RS23080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AW22_RS23085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AW22_RS23090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AW22_RS23120	COG0697	spore germination
AW22_RS23140	COG0745	RESPONSE REGULATOR receiver
AW22_RS23145	COG2205	protein histidine kinase activity
AW22_RS23210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AW22_RS23235	COG5002	protein histidine kinase activity
AW22_RS23245	COG2252	PERMEase
AW22_RS23260	COG5444	nuclease activity
AW22_RS23280	COG1266	CAAX protease self-immunity
AW22_RS23295	COG0488	(ABC) transporter
AW22_RS23305	COG0456	acetyltransferase
AW22_RS23310	COG1214	PFAM Peptidase M22, glycoprotease
AW22_RS23315	COG0802	atpase or kinase
AW22_RS23410	COG2183	response to ionizing radiation
AW22_RS23415	COG2337	Toxic component of a toxin-antitoxin (TA) module
AW22_RS23420	COG0864	Transcriptional regulator
AW22_RS23425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AW22_RS23430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AW22_RS23440	COG0457	Tetratricopeptide repeat
AW22_RS23440	COG0705	Rhomboid family
AW22_RS23445	COG4294	response to UV
AW22_RS23455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AW22_RS23465	COG2814	Major facilitator Superfamily
AW22_RS23480	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AW22_RS23515	COG0561	phosphatase activity
AW22_RS23520	COG4608	Belongs to the ABC transporter superfamily
AW22_RS23525	COG0444	Belongs to the ABC transporter superfamily
AW22_RS23530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AW22_RS23535	COG0601	transmembrane transport
AW22_RS23540	COG0747	negative chemotaxis
AW22_RS23555	COG0488	(ABC) transporter
AW22_RS23580	COG5298	Protein conserved in bacteria
AW22_RS23590	COG0084	hydrolase, TatD family'
AW22_RS23605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_RS23615	COG1609	Transcriptional regulator
AW22_RS23625	COG0204	Acyl-transferase
AW22_RS23635	COG0697	spore germination
AW22_RS23655	COG1910	domain protein
AW22_RS23660	COG0725	ABC transporter, periplasmic molybdate-binding protein
AW22_RS23665	COG4149	molybdate abc transporter
AW22_RS23685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AW22_RS23690	COG0656	L-ascorbic acid biosynthetic process
AW22_RS23695	COG4166	transmembrane transport
AW22_RS23700	COG4166	transmembrane transport
AW22_RS23715	COG2207	Transcriptional regulator
AW22_RS23725	COG4166	transmembrane transport
AW22_RS23730	COG4608	Belongs to the ABC transporter superfamily
AW22_RS23735	COG0444	Belongs to the ABC transporter superfamily
AW22_RS23740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AW22_RS23745	COG0601	transmembrane transport
AW22_RS23760	COG2814	Major facilitator Superfamily
AW22_RS23770	COG2271	Major facilitator Superfamily
AW22_RS23775	COG0277	FAD linked oxidase domain protein
AW22_RS23785	COG0604	alcohol dehydrogenase
AW22_RS23790	COG1464	Belongs to the NlpA lipoprotein family
AW22_RS23795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AW22_RS23800	COG2011	ABC-type metal ion transport system permease component
AW22_RS23805	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_RS23840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AW22_RS23885	COG4856	YbbR-like protein
AW22_RS23890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AW22_RS23970	COG0726	polysaccharide deacetylase
AW22_RS23975	COG2194	sulfuric ester hydrolase activity
AW22_RS23985	COG0489	protein tyrosine kinase activity
AW22_RS23990	COG0860	N-Acetylmuramoyl-L-alanine amidase
AW22_RS24015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AW22_RS24050	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AW22_RS24060	COG0024	Methionine aminopeptidase
AW22_RS24070	COG0201	protein transport
AW22_RS24130	COG0255	Belongs to the universal ribosomal protein uL29 family
AW22_RS24200	COG1358	cellular component organization or biogenesis
AW22_RS24215	COG2813	Specifically methylates the guanine in position
AW22_RS24235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AW22_RS24240	COG0250	Participates in transcription elongation, termination and antitermination
AW22_RS24245	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AW22_RS24260	COG3688	RNA-binding protein containing a PIN domain
AW22_RS24265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AW22_RS24280	COG1045	serine acetyltransferase
AW22_RS24300	COG4956	integral membrane protein (PIN domain superfamily)
AW22_RS24310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AW22_RS24315	COG0542	response to heat
AW22_RS24325	COG3880	PFAM UvrB UvrC protein
AW22_RS24415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AW22_RS24420	COG1396	sequence-specific DNA binding
AW22_RS24425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AW22_RS24430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AW22_RS24435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AW22_RS24440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AW22_RS24445	COG0512	Glutamine amidotransferase of anthranilate synthase
AW22_RS24450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AW22_RS24455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AW22_RS24470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AW22_RS24475	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AW22_RS24485	COG2208	phosphoserine phosphatase activity
AW22_RS24500	COG1098	S1 RNA binding domain
AW22_RS24520	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AW22_RS24525	COG3956	TIGRFAM MazG family protein
AW22_RS24530	COG2244	polysaccharide biosynthetic process
AW22_RS24535	COG2002	toxin-antitoxin pair type II binding
AW22_RS24540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AW22_RS24570	COG0251	oxidation-reduction process
AW22_RS24575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AW22_RS24590	COG4466	Protein conserved in bacteria
AW22_RS24605	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AW22_RS24610	COG0084	hydrolase, TatD family'
AW22_RS24615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AW22_RS24615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AW22_RS24620	COG2002	toxin-antitoxin pair type II binding
AW22_RS24625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AW22_RS24635	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AW22_RS24645	COG1774	PSP1 C-terminal conserved region
AW22_RS24650	COG0470	DNA polymerase III
AW22_RS24660	COG1982	Orn Lys Arg decarboxylase major
AW22_RS24715	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AW22_RS24720	COG0590	tRNA wobble adenosine to inosine editing
AW22_RS24730	COG1335	isochorismatase
AW22_RS24735	COG1428	Deoxynucleoside kinase
AW22_RS24740	COG1428	Deoxynucleoside kinase
AW22_RS24770	COG1686	Belongs to the peptidase S11 family
AW22_RS24775	COG0516	GMP reductase activity
AW22_RS24775	COG0517	IMP dehydrogenase activity
AW22_RS24810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AW22_RS24815	COG0187	DNA topoisomerase II activity
AW22_RS24825	COG2501	S4 domain
AW22_RS24830	COG0592	DNA-directed DNA polymerase activity
AW22_RS24840	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AW22_RS24850	COG0706	membrane insertase activity
AW22_RS24855	COG1847	R3H domain protein
AW22_RS24880	COG1192	Involved in chromosome partitioning
AW22_RS24885	COG1475	DNA binding
AW22_RS24895	COG0668	transmembrane transport
AW22_RS24900	COG4481	Protein conserved in bacteria
AW22_RS24905	COG0012	GTP binding
AW22_RS24915	COG0629	single-stranded DNA binding
AW22_RS24925	COG4241	membrane
AW22_RS24930	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AW22_RS24940	COG0305	Participates in initiation and elongation during chromosome replication
AW22_RS24970	COG0745	RESPONSE REGULATOR receiver
AW22_RS24975	COG5002	protein histidine kinase activity
AW22_RS24980	COG4863	YycH protein
AW22_RS24990	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AW22_RS24995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AW22_RS25015	COG1164	Oligoendopeptidase f
AW22_RS25040	COG1272	protein, Hemolysin III
AW22_RS25045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AW22_RS25065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AW22_RS25070	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AW22_RS25075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AW22_RS25080	COG2814	Major facilitator Superfamily
AW22_RS25085	COG3275	phosphorelay sensor kinase activity
AW22_RS25090	COG3279	Response regulator of the LytR AlgR family
AW22_RS25105	COG0628	permease
AW22_RS25110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AW22_RS25110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AW22_RS25115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AW22_RS25120	COG1309	transcriptional regulator
AW22_RS25125	COG0463	Glycosyl transferase, family 2
AW22_RS25145	COG0488	(ABC) transporter
AW22_RS25160	COG1607	acyl-coa hydrolase
AW22_RS25170	COG0840	transmembrane signaling receptor activity
AW22_RS25195	COG0477	Major facilitator Superfamily
AW22_RS25200	COG3279	Response regulator of the LytR AlgR family
AW22_RS25205	COG1966	Carbon starvation protein
AW22_RS25210	COG2879	small protein
AW22_RS25215	COG3706	GGDEF domain
AW22_RS25220	COG0351	phosphomethylpyrimidine kinase
AW22_RS25225	COG4585	Histidine kinase
AW22_RS25225	COG2203	Gaf domain
AW22_RS25230	COG2197	response regulator
AW22_RS25240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AW22_RS25255	COG1011	Hydrolase
AW22_RS25260	COG2873	o-acetylhomoserine
AW22_RS25270	COG0460	homoserine dehydrogenase
AW22_RS25280	COG1609	Transcriptional regulator
AW22_RS25285	COG2755	lipolytic protein G-D-S-L family
AW22_RS25290	COG1131	(ABC) transporter
AW22_RS25295	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AW22_RS25305	COG2814	Major facilitator Superfamily
AW22_RS25310	COG0561	phosphatase activity
AW22_RS25315	COG2233	PERMEase
AW22_RS25320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AW22_RS25330	COG2363	Small membrane protein
AW22_RS25340	COG3773	Cell wall hydrolase
AW22_RS25355	COG0280	phosphate acetyltransferase
AW22_RS25360	COG0095	Lipoate-protein ligase
AW22_RS25380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_RS25385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_RS25390	COG1120	ATPase activity
AW22_RS25395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_RS25400	COG1078	dGTPase activity
AW22_RS25410	COG1994	Peptidase M50
AW22_RS25420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW22_RS25425	COG0584	glycerophosphoryl diester phosphodiesterase
AW22_RS25430	COG0789	Transcriptional regulator
AW22_RS25435	COG2814	Major facilitator Superfamily
AW22_RS25445	COG0010	Belongs to the arginase family
AW22_RS25465	COG1619	proteins homologs of microcin C7 resistance protein MccF
AW22_RS25470	COG4506	Protein conserved in bacteria
AW22_RS25480	COG1595	DNA-templated transcription, initiation
AW22_RS25500	COG2234	aminopeptidase activity
AW22_RS25510	COG0024	Methionine aminopeptidase
AW22_RS25515	COG1131	(ABC) transporter
AW22_RS25520	COG0842	Transport permease protein
AW22_RS25525	COG4585	Histidine kinase
AW22_RS25530	COG2197	response regulator
AW22_RS25550	COG3300	MHYT domain
AW22_RS25550	COG5001	Diguanylate cyclase
AW22_RS25560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW22_RS25565	COG2181	nitrate reductase activity
AW22_RS25565	COG0247	lactate metabolic process
AW22_RS25570	COG0183	Belongs to the thiolase family
AW22_RS25575	COG1250	3-hydroxyacyl-CoA dehydrogenase
AW22_RS25580	COG1960	acyl-CoA dehydrogenase activity
AW22_RS25585	COG1960	acyl-CoA dehydrogenase activity
AW22_RS25605	COG4821	SIS domain
AW22_RS25625	COG1494	fructose-1,6-bisphosphatase
AW22_RS25630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AW22_RS25650	COG2890	protein-(glutamine-N5) methyltransferase activity
AW22_RS25665	COG0009	L-threonylcarbamoyladenylate synthase
AW22_RS25685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AW22_RS25690	COG2259	Doxx family
AW22_RS25695	COG2190	(PTS) system
AW22_RS25705	COG0698	ribose 5-phosphate isomerase
AW22_RS25740	COG0356	it plays a direct role in the translocation of protons across the membrane
AW22_RS25790	COG3300	MHYT domain
AW22_RS25790	COG5001	Diguanylate cyclase
AW22_RS25805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AW22_RS25810	COG0649	NAD binding
AW22_RS25825	COG0839	Belongs to the complex I subunit 6 family
AW22_RS25835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AW22_RS25840	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AW22_RS25845	COG1007	ATP synthesis coupled electron transport
AW22_RS25850	COG4836	Membrane
AW22_RS25865	COG2385	sporulation resulting in formation of a cellular spore
AW22_RS25870	COG3279	Response regulator of the LytR AlgR family
AW22_RS25885	COG0739	heme binding
AW22_RS25895	COG1609	Transcriptional regulator
AW22_RS25910	COG0489	protein tyrosine kinase activity
AW22_RS25915	COG3944	biosynthesis protein
AW22_RS25920	COG0489	protein tyrosine kinase activity
AW22_RS25925	COG4464	protein tyrosine phosphatase activity
AW22_RS25930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AW22_RS25935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AW22_RS25940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW22_RS25965	COG0438	transferase activity, transferring glycosyl groups
AW22_RS25975	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AW22_RS25980	COG0662	Cupin 2, conserved barrel domain protein
AW22_RS25980	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AW22_RS25990	COG1482	cell wall glycoprotein biosynthetic process
AW22_RS26005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AW22_RS26010	COG3711	transcriptional antiterminator
AW22_RS26010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW22_RS26015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW22_RS26015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AW22_RS26015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AW22_RS26020	COG1482	cell wall glycoprotein biosynthetic process
AW22_RS26025	COG0745	RESPONSE REGULATOR receiver
AW22_RS26065	COG1136	(ABC) transporter
AW22_RS26070	COG0577	efflux transmembrane transporter activity
AW22_RS26115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AW22_RS26120	COG4715	Zinc finger, swim domain protein
AW22_RS26145	COG3584	3D domain protein
AW22_RS26145	COG1388	LysM domain
AW22_RS26160	COG1215	transferase activity, transferring glycosyl groups
AW22_RS26170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_RS26175	COG0791	NLP P60 protein
AW22_RS26175	COG1388	LysM domain
AW22_RS26185	COG1368	sulfuric ester hydrolase activity
AW22_RS26195	COG2389	metal-binding protein
AW22_RS26210	COG1620	l-lactate permease
AW22_RS26220	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AW22_RS26225	COG1294	oxidase, subunit
AW22_RS26230	COG1271	oxidase subunit
AW22_RS26240	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AW22_RS26245	COG0583	DNA-binding transcription factor activity
AW22_RS26250	COG1511	domain protein
AW22_RS26270	COG0346	lactoylglutathione lyase activity
AW22_RS26280	COG1301	dicarboxylic acid transport
AW22_RS26285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AW22_RS26295	COG1447	Phosphotransferase system cellobiose-specific component IIA
AW22_RS26315	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AW22_RS26325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AW22_RS26330	COG1447	Phosphotransferase system cellobiose-specific component IIA
AW22_RS26335	COG1486	melibiose metabolic process
AW22_RS26365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AW22_RS26370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AW22_RS26375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AW22_RS26380	COG1316	TRANSCRIPTIONal
AW22_RS26385	COG1739	Uncharacterized protein family UPF0029
AW22_RS26390	COG1307	EDD domain protein, DegV family
AW22_RS26400	COG1733	regulation of RNA biosynthetic process
AW22_RS26405	COG0791	NLP P60 protein
AW22_RS26405	COG1388	LysM domain
AW22_RS26410	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AW22_RS26415	COG1040	competence protein
AW22_RS26420	COG1278	Cold shock
AW22_RS26425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AW22_RS26435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AW22_RS26450	COG2884	Cell division ATP-binding protein ftsE
AW22_RS26455	COG2177	Part of the ABC transporter FtsEX involved in
AW22_RS26460	COG0793	Belongs to the peptidase S41A family
AW22_RS26460	COG3409	Peptidoglycan-binding domain 1 protein
AW22_RS26465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AW22_RS26470	COG1132	(ABC) transporter
AW22_RS26480	COG0488	(ABC) transporter
AW22_RS26485	COG0655	NAD(P)H dehydrogenase (quinone) activity
AW22_RS26495	COG0583	DNA-binding transcription factor activity
AW22_RS26500	COG2855	membrane
AW22_RS26525	COG0789	Transcriptional regulator
AW22_RS26540	COG0556	nucleotide-excision repair
AW22_RS26545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AW22_RS26555	COG1950	PFAM Membrane protein of
AW22_RS26575	COG0110	maltose O-acetyltransferase activity
AW22_RS26580	COG0457	Tetratricopeptide repeat
AW22_RS26585	COG0492	ferredoxin-NADP+ reductase activity
AW22_RS26595	COG1051	belongs to the nudix hydrolase family
AW22_RS26605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AW22_RS26615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW22_RS26625	COG2323	membrane
AW22_RS26640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_RS26665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AW22_RS26680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AW22_RS26715	COG1346	cytolysis
AW22_RS26720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AW22_RS26725	COG1647	Serine aminopeptidase, S33
AW22_RS26730	COG0557	exoribonuclease II activity
AW22_RS26780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_RS26785	COG0488	(ABC) transporter
AW22_RS26810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AW22_RS26820	COG0840	transmembrane signaling receptor activity
AW22_RS26820	COG3290	protein histidine kinase activity
AW22_RS26835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AW22_RS26840	COG1252	NADH dehydrogenase
AW22_RS26850	COG1733	regulation of RNA biosynthetic process
AW22_RS26855	COG2814	Major facilitator Superfamily
AW22_RS26860	COG0656	L-ascorbic acid biosynthetic process
AW22_RS26875	COG2910	NAD(P)H-binding
AW22_RS26880	COG1115	amino acid carrier protein
AW22_RS26885	COG1115	amino acid carrier protein
AW22_RS26890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_RS26895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_RS26915	COG1611	Belongs to the LOG family
AW22_RS26930	COG0783	Belongs to the Dps family
AW22_RS26940	COG1115	amino acid carrier protein
AW22_RS26950	COG0490	domain, Protein
AW22_RS26955	COG0475	glutathione-regulated potassium exporter activity
AW22_RS26970	COG1741	Belongs to the pirin family
AW22_RS26975	COG3227	Zinc metalloprotease (Elastase)
AW22_RS26980	COG2151	metal-sulfur cluster biosynthetic enzyme
AW22_RS26985	COG0840	transmembrane signaling receptor activity
AW22_RS27010	COG5002	protein histidine kinase activity
AW22_RS27015	COG0745	RESPONSE REGULATOR receiver
AW22_RS27020	COG1376	ErfK ybiS ycfS ynhG family protein
AW22_RS27030	COG0586	Pfam SNARE associated Golgi protein
AW22_RS27065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_RS27075	COG0706	membrane insertase activity
AW22_RS27090	COG0531	amino acid
AW22_RS27095	COG2814	Major facilitator Superfamily
AW22_RS27115	COG0840	transmembrane signaling receptor activity
AW22_RS27120	COG0011	TIGRFAM Protein of
AW22_RS27135	COG1686	Belongs to the peptidase S11 family
AW22_RS27145	COG1250	3-hydroxyacyl-CoA dehydrogenase
AW22_RS27145	COG1024	Enoyl-CoA hydratase
AW22_RS27150	COG0183	Belongs to the thiolase family
AW22_RS27155	COG1960	acyl-CoA dehydrogenase activity
AW22_RS27180	COG4555	ABC transporter
AW22_RS27195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_RS27200	COG1309	transcriptional regulator
AW22_RS27225	COG0039	L-malate dehydrogenase activity
AW22_RS27275	COG1393	Belongs to the ArsC family
AW22_RS27285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AW22_RS27290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW22_RS27305	COG2011	ABC-type metal ion transport system permease component
AW22_RS27310	COG1464	Belongs to the NlpA lipoprotein family
AW22_RS27315	COG1464	Belongs to the NlpA lipoprotein family
AW22_RS27320	COG0396	ATPase activity
AW22_RS27325	COG0719	Fe-S assembly protein
AW22_RS27330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AW22_RS27335	COG0822	iron-sulfur transferase activity
AW22_RS27340	COG0719	Fe-S assembly protein
AW22_RS27350	COG1695	Transcriptional regulator
AW22_RS27360	COG0737	Belongs to the 5'-nucleotidase family
AW22_RS27365	COG3377	Domain of unknown function (DUF1805)
AW22_RS27375	COG0739	heme binding
AW22_RS27400	COG4377	Putative membrane peptidase family (DUF2324)
AW22_RS27405	COG0789	Transcriptional regulator
AW22_RS27415	COG4470	Protein conserved in bacteria
AW22_RS27435	COG1494	fructose-1,6-bisphosphatase
AW22_RS27440	COG2445	Protein of unknown function DUF86
AW22_RS27450	COG0647	UMP catabolic process
AW22_RS27455	COG2249	NAD(P)H dehydrogenase (quinone) activity
AW22_RS27460	COG0577	efflux transmembrane transporter activity
AW22_RS27460	COG1136	(ABC) transporter
AW22_RS27480	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AW22_RS27485	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AW22_RS27500	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AW22_RS27505	COG4837	Protein of unknown function (DUF1462)
AW22_RS27525	COG2824	Alkylphosphonate utilization operon protein PhnA
AW22_RS27530	COG0390	transport system, permease component
AW22_RS27535	COG2274	protein secretion by the type I secretion system
AW22_RS27545	COG1252	NADH dehydrogenase
AW22_RS27560	COG0316	Belongs to the HesB IscA family
AW22_RS27575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AW22_RS27795	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_RS27815	COG1683	Conserved Protein
AW22_RS27830	COG3708	Transcriptional regulator
AW22_RS27845	COG1252	NADH dehydrogenase
AW22_RS27860	COG3584	3D domain protein
AW22_RS27875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AW22_RS27880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AW22_RS27885	COG1268	BioY protein
AW22_RS27895	COG2050	protein possibly involved in aromatic compounds catabolism
AW22_RS27915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AW22_RS27920	COG5018	Exonuclease
AW22_RS27940	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AW22_RS27950	COG2267	carboxylic ester hydrolase activity
AW22_RS27955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AW22_RS27960	COG1522	sequence-specific DNA binding
AW22_RS27965	COG0436	Aminotransferase
AW22_RS27970	COG1098	S1 RNA binding domain
AW22_RS27975	COG2155	Conserved Protein
AW22_RS27995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AW22_RS28000	COG1285	pathogenesis
AW22_RS28035	COG0544	peptidyl-prolyl cis-trans isomerase activity
AW22_RS28135	COG1404	Belongs to the peptidase S8 family
AW22_RS28155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AW22_RS28165	COG0058	SHG alpha-glucan phosphorylase activity
AW22_RS28190	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AW22_RS28195	COG1575	Belongs to the MenA family. Type 1 subfamily
AW22_RS28200	COG1169	isochorismate synthase
AW22_RS28210	COG0596	Alpha beta hydrolase
AW22_RS28215	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AW22_RS28225	COG4948	Mandelate Racemase Muconate Lactonizing
AW22_RS28245	COG3964	amidohydrolase
AW22_RS28265	COG2188	Transcriptional regulator
AW22_RS28280	COG0577	efflux transmembrane transporter activity
AW22_RS28285	COG1136	(ABC) transporter
AW22_RS28290	COG0577	efflux transmembrane transporter activity
AW22_RS28295	COG0577	efflux transmembrane transporter activity
AW22_RS28300	COG2205	protein histidine kinase activity
AW22_RS28305	COG0745	RESPONSE REGULATOR receiver
AW22_RS28310	COG2207	Transcriptional regulator
AW22_RS28310	COG3708	Transcriptional regulator
AW22_RS28315	COG1136	(ABC) transporter
AW22_RS28320	COG0577	efflux transmembrane transporter activity
AW22_RS28330	COG0586	Pfam SNARE associated Golgi protein
AW22_RS28355	COG1597	lipid kinase activity
AW22_RS28360	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AW22_RS28385	COG0745	RESPONSE REGULATOR receiver
AW22_RS28390	COG5002	protein histidine kinase activity
AW22_RS28395	COG3859	Proton-coupled thiamine transporter YuaJ
AW22_RS28465	COG1842	Phage shock protein A
AW22_RS28490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_RS28510	COG1294	oxidase, subunit
AW22_RS28515	COG1271	oxidase subunit
AW22_RS28520	COG0288	reversible hydration of carbon dioxide
AW22_RS28550	COG0494	nUDIX hydrolase
AW22_RS28575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AW22_RS28580	COG1116	anion transmembrane transporter activity
AW22_RS28585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AW22_RS28600	COG1368	sulfuric ester hydrolase activity
AW22_RS28605	COG2267	carboxylic ester hydrolase activity
AW22_RS28610	COG4191	Histidine kinase
AW22_RS28615	COG5002	protein histidine kinase activity
AW22_RS28625	COG1349	DNA-binding transcription factor activity
AW22_RS28630	COG0546	phosphoglycolate phosphatase activity
AW22_RS28690	COG0521	Mo-molybdopterin cofactor biosynthetic process
AW22_RS28700	COG0438	transferase activity, transferring glycosyl groups
AW22_RS28705	COG0671	phosphoesterase, PA-phosphatase related
AW22_RS28710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AW22_RS28715	COG2267	carboxylic ester hydrolase activity
AW22_RS28740	COG5504	Zn-dependent protease
AW22_RS28750	COG1794	racemase activity, acting on amino acids and derivatives
AW22_RS28765	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AW22_RS28770	COG1242	4 iron, 4 sulfur cluster binding
AW22_RS28790	COG1136	(ABC) transporter
AW22_RS28800	COG0582	viral genome integration into host DNA
AW22_RS28805	COG0490	domain, Protein
AW22_RS28810	COG0475	glutathione-regulated potassium exporter activity
AW22_RS28815	COG2814	Major facilitator Superfamily
AW22_RS28860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AW22_RS28870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW22_RS28890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AW22_RS28895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AW22_RS28905	COG0303	'Molybdopterin
AW22_RS28910	COG1763	Mo-molybdopterin cofactor biosynthetic process
AW22_RS28915	COG0314	molybdopterin synthase activity
AW22_RS28940	COG1329	Transcriptional regulator
AW22_RS28960	COG3832	glyoxalase III activity
AW22_RS28970	COG2814	Major facilitator Superfamily
AW22_RS28975	COG2081	HI0933 family
AW22_RS28980	COG2244	polysaccharide biosynthetic process
AW22_RS28985	COG1187	pseudouridine synthase activity
AW22_RS28990	COG1349	DNA-binding transcription factor activity
AW22_RS28995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AW22_RS29010	COG1523	belongs to the glycosyl hydrolase 13 family
AW22_RS29015	COG0510	thiamine kinase activity
AW22_RS29030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_RS29040	COG1363	Peptidase, m42
AW22_RS29045	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AW22_RS29050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW22_RS29060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AW22_RS29070	COG1674	ftsk spoiiie
AW22_RS29090	COG1695	Transcriptional regulator
AW22_RS29095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_RS29105	COG1136	(ABC) transporter
AW22_RS29110	COG0577	efflux transmembrane transporter activity
AW22_RS29130	COG2309	aminopeptidase activity
AW22_RS29140	COG3118	belongs to the thioredoxin family
AW22_RS29145	COG4851	CamS sex pheromone cAM373 precursor
AW22_RS29155	COG1609	Transcriptional regulator
AW22_RS29190	COG0666	response to abiotic stimulus
AW22_RS29195	COG5002	protein histidine kinase activity
AW22_RS29215	COG0123	including yeast histone deacetylase and acetoin utilization protein
AW22_RS29220	COG0517	IMP dehydrogenase activity
AW22_RS29225	COG0454	-acetyltransferase
AW22_RS29230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AW22_RS29240	COG1595	DNA-templated transcription, initiation
AW22_RS29275	COG1956	GAF domain-containing protein
AW22_RS29285	COG0697	spore germination
AW22_RS29290	COG0583	DNA-binding transcription factor activity
AW22_RS29300	COG1104	cysteine desulfurase activity
AW22_RS29315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AW22_RS29325	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AW22_RS29340	COG3874	Sporulation protein YtfJ
AW22_RS29345	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AW22_RS29350	COG0827	DNA restriction-modification system
AW22_RS29355	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AW22_RS29385	COG4886	Leucine-rich repeat (LRR) protein
AW22_RS29385	COG4932	domain protein
AW22_RS29415	COG2376	Dihydroxyacetone kinase