locus-tag	class	description
M6D84_RS00010	COG0592	DNA-directed DNA polymerase activity
M6D84_RS00015	COG2501	S4 domain
M6D84_RS00025	COG0187	DNA topoisomerase II activity
M6D84_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M6D84_RS00065	COG0516	GMP reductase activity
M6D84_RS00065	COG0517	IMP dehydrogenase activity
M6D84_RS00070	COG1686	Belongs to the peptidase S11 family
M6D84_RS00100	COG1428	Deoxynucleoside kinase
M6D84_RS00105	COG1428	Deoxynucleoside kinase
M6D84_RS00110	COG1335	isochorismatase
M6D84_RS00115	COG0590	tRNA wobble adenosine to inosine editing
M6D84_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M6D84_RS00180	COG1982	Orn Lys Arg decarboxylase major
M6D84_RS00190	COG0470	DNA polymerase III
M6D84_RS00195	COG1774	PSP1 C-terminal conserved region
M6D84_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M6D84_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M6D84_RS00220	COG2002	toxin-antitoxin pair type II binding
M6D84_RS00230	COG0084	hydrolase, TatD family'
M6D84_RS00250	COG4466	Protein conserved in bacteria
M6D84_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M6D84_RS00270	COG0251	oxidation-reduction process
M6D84_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M6D84_RS00305	COG2002	toxin-antitoxin pair type II binding
M6D84_RS00310	COG2244	polysaccharide biosynthetic process
M6D84_RS00315	COG3956	TIGRFAM MazG family protein
M6D84_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M6D84_RS00340	COG1098	S1 RNA binding domain
M6D84_RS00355	COG2208	phosphoserine phosphatase activity
M6D84_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M6D84_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M6D84_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M6D84_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M6D84_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
M6D84_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6D84_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M6D84_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M6D84_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M6D84_RS00420	COG1396	sequence-specific DNA binding
M6D84_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M6D84_RS00515	COG3880	PFAM UvrB UvrC protein
M6D84_RS00525	COG0542	response to heat
M6D84_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M6D84_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
M6D84_RS00560	COG1045	serine acetyltransferase
M6D84_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M6D84_RS00580	COG3688	RNA-binding protein containing a PIN domain
M6D84_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M6D84_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
M6D84_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M6D84_RS00625	COG2813	Specifically methylates the guanine in position
M6D84_RS00640	COG1358	cellular component organization or biogenesis
M6D84_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M6D84_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
M6D84_RS00770	COG0201	protein transport
M6D84_RS00780	COG0024	Methionine aminopeptidase
M6D84_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M6D84_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M6D84_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_RS00855	COG0489	protein tyrosine kinase activity
M6D84_RS00865	COG2194	sulfuric ester hydrolase activity
M6D84_RS00870	COG0726	polysaccharide deacetylase
M6D84_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M6D84_RS00955	COG4856	YbbR-like protein
M6D84_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS01010	COG2011	ABC-type metal ion transport system permease component
M6D84_RS01015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M6D84_RS01020	COG1464	Belongs to the NlpA lipoprotein family
M6D84_RS01025	COG0604	alcohol dehydrogenase
M6D84_RS01035	COG0277	FAD linked oxidase domain protein
M6D84_RS01040	COG2271	Major facilitator Superfamily
M6D84_RS01050	COG2814	Major facilitator Superfamily
M6D84_RS01065	COG0601	transmembrane transport
M6D84_RS01070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D84_RS01075	COG0444	Belongs to the ABC transporter superfamily
M6D84_RS01080	COG4608	Belongs to the ABC transporter superfamily
M6D84_RS01085	COG4166	transmembrane transport
M6D84_RS01095	COG2207	Transcriptional regulator
M6D84_RS01110	COG4166	transmembrane transport
M6D84_RS01115	COG4166	transmembrane transport
M6D84_RS01120	COG0656	L-ascorbic acid biosynthetic process
M6D84_RS01135	COG4149	molybdate abc transporter
M6D84_RS01140	COG0725	ABC transporter, periplasmic molybdate-binding protein
M6D84_RS01145	COG1910	domain protein
M6D84_RS01160	COG0697	spore germination
M6D84_RS01175	COG0204	Acyl-transferase
M6D84_RS01185	COG1609	Transcriptional regulator
M6D84_RS01195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_RS01210	COG5298	Protein conserved in bacteria
M6D84_RS01235	COG0488	(ABC) transporter
M6D84_RS01245	COG0747	negative chemotaxis
M6D84_RS01250	COG0601	transmembrane transport
M6D84_RS01255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D84_RS01260	COG0444	Belongs to the ABC transporter superfamily
M6D84_RS01265	COG4608	Belongs to the ABC transporter superfamily
M6D84_RS01270	COG0561	phosphatase activity
M6D84_RS01300	COG3185	4-Hydroxyphenylpyruvate dioxygenase
M6D84_RS01305	COG0179	Fumarylacetoacetate (FAA) hydrolase
M6D84_RS01315	COG0531	amino acid
M6D84_RS01320	COG2814	Major facilitator Superfamily
M6D84_RS01330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M6D84_RS01340	COG4294	response to UV
M6D84_RS01345	COG0705	Rhomboid family
M6D84_RS01355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M6D84_RS01360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M6D84_RS01365	COG0864	Transcriptional regulator
M6D84_RS01370	COG2337	Toxic component of a toxin-antitoxin (TA) module
M6D84_RS01375	COG2183	response to ionizing radiation
M6D84_RS01475	COG0802	atpase or kinase
M6D84_RS01480	COG1214	PFAM Peptidase M22, glycoprotease
M6D84_RS01485	COG0456	acetyltransferase
M6D84_RS01495	COG0488	(ABC) transporter
M6D84_RS01510	COG1266	CAAX protease self-immunity
M6D84_RS01530	COG2252	PERMEase
M6D84_RS01540	COG5002	protein histidine kinase activity
M6D84_RS01565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M6D84_RS01605	COG2205	protein histidine kinase activity
M6D84_RS01610	COG0745	RESPONSE REGULATOR receiver
M6D84_RS01635	COG2226	methyltransferase
M6D84_RS01645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M6D84_RS01655	COG0463	Glycosyl transferase, family 2
M6D84_RS01655	COG1216	Glycosyl transferase, family 2
M6D84_RS01675	COG0697	spore germination
M6D84_RS01705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M6D84_RS01710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M6D84_RS01715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M6D84_RS01725	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M6D84_RS01740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M6D84_RS01750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M6D84_RS01760	COG0151	Belongs to the GarS family
M6D84_RS01785	COG0210	DNA helicase
M6D84_RS01795	COG4851	CamS sex pheromone cAM373 precursor
M6D84_RS01810	COG1335	isochorismatase
M6D84_RS01820	COG2011	ABC-type metal ion transport system permease component
M6D84_RS01825	COG1464	Belongs to the NlpA lipoprotein family
M6D84_RS01840	COG0003	Pfam Anion-transporting ATPase
M6D84_RS01845	COG1846	Transcriptional regulator
M6D84_RS01850	COG4682	membrane
M6D84_RS01870	COG1597	lipid kinase activity
M6D84_RS01880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M6D84_RS01890	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_RS01895	COG2076	Multidrug Resistance protein
M6D84_RS01905	COG2309	aminopeptidase activity
M6D84_RS01925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_RS01935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M6D84_RS01940	COG4807	Protein conserved in bacteria
M6D84_RS01965	COG1757	Na H antiporter
M6D84_RS01970	COG1473	amidohydrolase
M6D84_RS01985	COG0450	alkyl hydroperoxide reductase
M6D84_RS02005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_RS02010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_RS02015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_RS02020	COG0492	ferredoxin-NADP+ reductase activity
M6D84_RS02030	COG0166	Belongs to the GPI family
M6D84_RS02055	COG5002	protein histidine kinase activity
M6D84_RS02075	COG3541	Predicted nucleotidyltransferase
M6D84_RS02080	COG2814	Major facilitator Superfamily
M6D84_RS02085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D84_RS02085	COG0723	plastoquinol--plastocyanin reductase activity
M6D84_RS02095	COG0765	amino acid transport
M6D84_RS02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_RS02110	COG0840	transmembrane signaling receptor activity
M6D84_RS02135	COG0549	Belongs to the carbamate kinase family
M6D84_RS02140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M6D84_RS02150	COG0277	FAD linked oxidase domain protein
M6D84_RS02155	COG0366	Alpha amylase catalytic
M6D84_RS02160	COG2190	(PTS) system
M6D84_RS02160	COG1263	PTS System
M6D84_RS02160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_RS02190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M6D84_RS02210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D84_RS02215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M6D84_RS02220	COG1116	anion transmembrane transporter activity
M6D84_RS02270	COG2270	Major facilitator Superfamily
M6D84_RS02300	COG2310	stress, protein
M6D84_RS02305	COG2310	stress, protein
M6D84_RS02310	COG2310	stress, protein
M6D84_RS02315	COG0861	Integral membrane protein TerC family
M6D84_RS02325	COG3853	Toxic anion resistance protein (TelA)
M6D84_RS02340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M6D84_RS02350	COG1295	ribonuclease BN
M6D84_RS02355	COG2217	Heavy metal translocating P-type atpase
M6D84_RS02360	COG0697	spore germination
M6D84_RS02370	COG0681	Belongs to the peptidase S26 family
M6D84_RS02380	COG0586	Pfam SNARE associated Golgi protein
M6D84_RS02395	COG3871	stress protein (general stress protein 26)
M6D84_RS02400	COG0387	Pfam Sodium calcium exchanger
M6D84_RS02410	COG0535	radical SAM domain protein
M6D84_RS02430	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M6D84_RS02435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M6D84_RS02450	COG3829	transcription factor binding
M6D84_RS02460	COG0833	amino acid
M6D84_RS02465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M6D84_RS02495	COG1263	PTS System
M6D84_RS02495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_RS02500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_RS02515	COG0463	Glycosyl transferase, family 2
M6D84_RS02525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M6D84_RS02525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M6D84_RS02545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M6D84_RS02565	COG1228	amidohydrolase
M6D84_RS02570	COG1090	epimerase
M6D84_RS02600	COG1988	membrane-bound metal-dependent
M6D84_RS02605	COG1194	a g-specific adenine glycosylase
M6D84_RS02630	COG1132	(ABC) transporter
M6D84_RS02635	COG4129	membrane
M6D84_RS02640	COG0070	glutamate synthase
M6D84_RS02640	COG0069	glutamate synthase activity
M6D84_RS02640	COG0067	glutamate synthase
M6D84_RS02650	COG4555	ABC transporter
M6D84_RS02670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M6D84_RS02675	COG0735	belongs to the Fur family
M6D84_RS02795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M6D84_RS02820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M6D84_RS02830	COG2766	serine protein kinase
M6D84_RS02850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M6D84_RS02860	COG1585	Membrane protein implicated in regulation of membrane protease activity
M6D84_RS02865	COG2268	Band 7 protein
M6D84_RS02875	COG3290	protein histidine kinase activity
M6D84_RS02880	COG4565	transcriptional regulatory protein
M6D84_RS02885	COG2851	Citrate transporter
M6D84_RS02910	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M6D84_RS02915	COG3842	ATPase activity
M6D84_RS02920	COG1175	transmembrane transport
M6D84_RS02925	COG0395	ABC-type sugar transport system, permease component
M6D84_RS02935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M6D84_RS02940	COG0745	RESPONSE REGULATOR receiver
M6D84_RS02945	COG5002	protein histidine kinase activity
M6D84_RS02945	COG3850	Histidine kinase
M6D84_RS02955	COG4990	cell redox homeostasis
M6D84_RS02965	COG3290	protein histidine kinase activity
M6D84_RS02970	COG4565	transcriptional regulatory protein
M6D84_RS02975	COG3493	citrate carrier protein
M6D84_RS02980	COG0281	malic enzyme
M6D84_RS02990	COG0697	spore germination
M6D84_RS02995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_RS03005	COG5002	protein histidine kinase activity
M6D84_RS03015	COG0456	acetyltransferase
M6D84_RS03015	COG0454	-acetyltransferase
M6D84_RS03020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M6D84_RS03025	COG3383	formate dehydrogenase (NAD+) activity
M6D84_RS03030	COG2427	Protein of unknown function (DUF1641)
M6D84_RS03045	COG0531	amino acid
M6D84_RS03055	COG0640	Transcriptional regulator
M6D84_RS03060	COG2217	Heavy metal translocating P-type atpase
M6D84_RS03065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M6D84_RS03080	COG3227	Zinc metalloprotease (Elastase)
M6D84_RS03100	COG2720	vancomycin resistance protein
M6D84_RS03105	COG1316	TRANSCRIPTIONal
M6D84_RS03110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_RS03115	COG0346	lactoylglutathione lyase activity
M6D84_RS03120	COG1253	flavin adenine dinucleotide binding
M6D84_RS03125	COG1027	Aspartate ammonia-lyase
M6D84_RS03130	COG1620	l-lactate permease
M6D84_RS03145	COG3104	oligopeptide transport
M6D84_RS03150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_RS03155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_RS03160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_RS03170	COG2226	methyltransferase
M6D84_RS03180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M6D84_RS03190	COG4548	von Willebrand factor, type A
M6D84_RS03195	COG0714	Associated with various cellular activities
M6D84_RS03215	COG0531	amino acid
M6D84_RS03220	COG2188	Transcriptional regulator
M6D84_RS03225	COG1263	PTS System
M6D84_RS03225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_RS03230	COG0366	Alpha amylase catalytic
M6D84_RS03245	COG0697	spore germination
M6D84_RS03250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M6D84_RS03255	COG1115	amino acid carrier protein
M6D84_RS03260	COG1126	abc transporter atp-binding protein
M6D84_RS03265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_RS03270	COG0765	amino acid transport
M6D84_RS03275	COG0765	amino acid transport
M6D84_RS03280	COG0833	amino acid
M6D84_RS03295	COG2378	regulation of single-species biofilm formation
M6D84_RS03300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M6D84_RS03305	COG5002	protein histidine kinase activity
M6D84_RS03320	COG0659	secondary active sulfate transmembrane transporter activity
M6D84_RS03335	COG2271	Major facilitator Superfamily
M6D84_RS03340	COG1846	Transcriptional regulator
M6D84_RS03345	COG0477	Major facilitator Superfamily
M6D84_RS03350	COG1609	Transcriptional regulator
M6D84_RS03355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M6D84_RS03370	COG1172	Belongs to the binding-protein-dependent transport system permease family
M6D84_RS03375	COG1879	ABC-type sugar transport system periplasmic component
M6D84_RS03400	COG1063	alcohol dehydrogenase
M6D84_RS03450	COG0840	transmembrane signaling receptor activity
M6D84_RS03455	COG1388	LysM domain
M6D84_RS03455	COG3584	3D domain protein
M6D84_RS03460	COG1476	TRANSCRIPTIONal
M6D84_RS03480	COG3104	oligopeptide transport
M6D84_RS03485	COG1114	Component of the transport system for branched-chain amino acids
M6D84_RS03500	COG1113	amino acid transport
M6D84_RS03505	COG2252	PERMEase
M6D84_RS03530	COG2153	protein acetylation
M6D84_RS03540	COG0569	domain protein
M6D84_RS03540	COG0475	glutathione-regulated potassium exporter activity
M6D84_RS03550	COG1845	cytochrome c oxidase, subunit III
M6D84_RS03555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M6D84_RS03565	COG0833	amino acid
M6D84_RS03570	COG4990	cell redox homeostasis
M6D84_RS03585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6D84_RS03590	COG0697	spore germination
M6D84_RS03595	COG0531	amino acid
M6D84_RS03610	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M6D84_RS03615	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M6D84_RS03620	COG1918	ferrous iron import across plasma membrane
M6D84_RS03620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M6D84_RS03625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M6D84_RS03630	COG0573	inorganic phosphate transmembrane transporter activity
M6D84_RS03635	COG0581	inorganic phosphate transmembrane transporter activity
M6D84_RS03640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M6D84_RS03760	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M6D84_RS03780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M6D84_RS03785	COG1116	anion transmembrane transporter activity
M6D84_RS03790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D84_RS03795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M6D84_RS03800	COG0352	thiamine-phosphate diphosphorylase activity
M6D84_RS03805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D84_RS03810	COG2104	thiamine diphosphate biosynthetic process
M6D84_RS03820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M6D84_RS03825	COG0351	phosphomethylpyrimidine kinase
M6D84_RS03865	COG2205	protein histidine kinase activity
M6D84_RS03870	COG2814	Major facilitator Superfamily
M6D84_RS03875	COG1846	Transcriptional regulator
M6D84_RS03885	COG2252	PERMEase
M6D84_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS03905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M6D84_RS03910	COG1621	beta-fructofuranosidase activity
M6D84_RS03915	COG1263	PTS System
M6D84_RS03915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_RS03920	COG1609	Transcriptional regulator
M6D84_RS03970	COG0778	Nitroreductase
M6D84_RS03975	COG2719	SpoVR family
M6D84_RS03985	COG3591	Belongs to the peptidase S1B family
M6D84_RS03995	COG1414	Transcriptional regulator
M6D84_RS04010	COG0446	pyridine nucleotide-disulphide oxidoreductase
M6D84_RS04015	COG1937	Protein conserved in bacteria
M6D84_RS04020	COG0425	Belongs to the sulfur carrier protein TusA family
M6D84_RS04020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_RS04025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_RS04025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_RS04030	COG0425	Belongs to the sulfur carrier protein TusA family
M6D84_RS04035	COG0425	Belongs to the sulfur carrier protein TusA family
M6D84_RS04035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_RS04040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_RS04045	COG2210	Belongs to the sulfur carrier protein TusA family
M6D84_RS04050	COG0730	response to heat
M6D84_RS04060	COG1316	TRANSCRIPTIONal
M6D84_RS04065	COG0604	alcohol dehydrogenase
M6D84_RS04070	COG1283	sodium-dependent phosphate transmembrane transporter activity
M6D84_RS04085	COG3711	transcriptional antiterminator
M6D84_RS04085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6D84_RS04090	COG1447	Phosphotransferase system cellobiose-specific component IIA
M6D84_RS04095	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M6D84_RS04120	COG3584	3D domain protein
M6D84_RS04120	COG1388	LysM domain
M6D84_RS04125	COG0577	efflux transmembrane transporter activity
M6D84_RS04130	COG1136	(ABC) transporter
M6D84_RS04140	COG5522	Integral membrane protein (intg_mem_TP0381)
M6D84_RS04155	COG1114	Component of the transport system for branched-chain amino acids
M6D84_RS04160	COG3546	catalase activity
M6D84_RS04195	COG0586	Pfam SNARE associated Golgi protein
M6D84_RS04230	COG0531	amino acid
M6D84_RS04235	COG0475	glutathione-regulated potassium exporter activity
M6D84_RS04245	COG1737	Transcriptional regulator
M6D84_RS04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_RS04255	COG1263	PTS System
M6D84_RS04265	COG2259	Doxx family
M6D84_RS04285	COG1522	sequence-specific DNA binding
M6D84_RS04290	COG0165	Argininosuccinate lyase
M6D84_RS04290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M6D84_RS04295	COG0300	oxidoreductase activity
M6D84_RS04315	COG1309	transcriptional regulator
M6D84_RS04320	COG2814	Major facilitator Superfamily
M6D84_RS04325	COG1733	regulation of RNA biosynthetic process
M6D84_RS04340	COG4533	DNA binding
M6D84_RS04345	COG2211	Major facilitator Superfamily
M6D84_RS04360	COG0693	protein deglycase activity
M6D84_RS04365	COG0753	catalase activity
M6D84_RS04365	COG0693	protein deglycase activity
M6D84_RS04375	COG0531	amino acid
M6D84_RS04380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M6D84_RS04390	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_RS04395	COG1132	(ABC) transporter
M6D84_RS04400	COG1132	(ABC) transporter
M6D84_RS04405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_RS04410	COG0765	amino acid transport
M6D84_RS04415	COG1126	abc transporter atp-binding protein
M6D84_RS04430	COG0189	ligase activity
M6D84_RS04465	COG0028	Belongs to the TPP enzyme family
M6D84_RS04470	COG3527	Alpha-acetolactate decarboxylase
M6D84_RS04480	COG0561	phosphatase activity
M6D84_RS04490	COG3409	Peptidoglycan-binding domain 1 protein
M6D84_RS04490	COG5632	N-Acetylmuramoyl-L-alanine amidase
M6D84_RS04495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M6D84_RS04515	COG0659	secondary active sulfate transmembrane transporter activity
M6D84_RS04520	COG2244	polysaccharide biosynthetic process
M6D84_RS04540	COG1024	Enoyl-CoA hydratase
M6D84_RS04560	COG1363	Peptidase, m42
M6D84_RS04595	COG0601	transmembrane transport
M6D84_RS04600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D84_RS04605	COG0444	Belongs to the ABC transporter superfamily
M6D84_RS04610	COG4608	Belongs to the ABC transporter superfamily
M6D84_RS04620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_RS04635	COG1136	(ABC) transporter
M6D84_RS04635	COG0577	efflux transmembrane transporter activity
M6D84_RS04690	COG0477	Major facilitator Superfamily
M6D84_RS04695	COG3290	protein histidine kinase activity
M6D84_RS04700	COG4565	transcriptional regulatory protein
M6D84_RS04705	COG3181	Tripartite tricarboxylate transporter family receptor
M6D84_RS04725	COG3973	AAA domain
M6D84_RS04765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M6D84_RS04790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M6D84_RS04815	COG0305	Participates in initiation and elongation during chromosome replication
M6D84_RS04845	COG0477	Major facilitator Superfamily
M6D84_RS04865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS04875	COG1073	alpha beta
M6D84_RS04915	COG1183	phosphatidylcholine synthase activity
M6D84_RS04930	COG2376	Dihydroxyacetone kinase
M6D84_RS04940	COG2376	Dihydroxyacetone kinase
M6D84_RS04975	COG3584	3D domain protein
M6D84_RS04975	COG1388	LysM domain
M6D84_RS04980	COG1388	LysM domain
M6D84_RS04980	COG0791	NLP P60 protein
M6D84_RS04985	COG2373	Large extracellular alpha-helical protein
M6D84_RS05055	COG1191	sigma factor activity
M6D84_RS05065	COG2208	phosphoserine phosphatase activity
M6D84_RS05070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M6D84_RS05075	COG0784	Response regulator, receiver
M6D84_RS05075	COG2205	protein histidine kinase activity
M6D84_RS05075	COG5002	protein histidine kinase activity
M6D84_RS05120	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M6D84_RS05140	COG0420	3'-5' exonuclease activity
M6D84_RS05145	COG4717	serine-type aminopeptidase activity
M6D84_RS05155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_RS05170	COG0346	lactoylglutathione lyase activity
M6D84_RS05175	COG0346	lactoylglutathione lyase activity
M6D84_RS05180	COG0457	Tetratricopeptide repeat
M6D84_RS05190	COG2267	carboxylic ester hydrolase activity
M6D84_RS05215	COG2140	Oxalate decarboxylase
M6D84_RS05220	COG3620	sequence-specific DNA binding
M6D84_RS05225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M6D84_RS05230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M6D84_RS05240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M6D84_RS05245	COG1695	Transcriptional regulator
M6D84_RS05275	COG3973	AAA domain
M6D84_RS05305	COG4980	gas vesicle protein
M6D84_RS05310	COG0537	adenosine 5'-monophosphoramidase activity
M6D84_RS05315	COG1131	(ABC) transporter
M6D84_RS05320	COG4473	ABC transporter
M6D84_RS05345	COG3402	PFAM membrane-flanked domain
M6D84_RS05350	COG3428	Bacterial PH domain
M6D84_RS05385	COG0697	spore germination
M6D84_RS05390	COG3402	PFAM membrane-flanked domain
M6D84_RS05400	COG2329	Antibiotic biosynthesis monooxygenase
M6D84_RS05405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D84_RS05420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M6D84_RS05455	COG1309	transcriptional regulator
M6D84_RS05460	COG1511	domain protein
M6D84_RS05490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS05495	COG1609	Transcriptional regulator
M6D84_RS05505	COG1234	tRNA 3'-trailer cleavage
M6D84_RS05510	COG0095	Lipoate-protein ligase
M6D84_RS05520	COG0318	PFAM AMP-dependent synthetase and ligase
M6D84_RS05530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M6D84_RS05540	COG4208	sulfate ABC transporter
M6D84_RS05635	COG1408	metallophosphoesterase
M6D84_RS05640	COG1078	dGTPase activity
M6D84_RS05650	COG1595	DNA-templated transcription, initiation
M6D84_RS05655	COG3708	Transcriptional regulator
M6D84_RS05655	COG2207	Transcriptional regulator
M6D84_RS05665	COG2205	protein histidine kinase activity
M6D84_RS05670	COG0745	RESPONSE REGULATOR receiver
M6D84_RS05690	COG0501	Belongs to the peptidase M48B family
M6D84_RS05695	COG0840	transmembrane signaling receptor activity
M6D84_RS05700	COG3693	PFAM glycoside hydrolase, family 10
M6D84_RS05710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M6D84_RS05715	COG2224	Isocitrate lyase
M6D84_RS05730	COG1278	Cold shock
M6D84_RS05750	COG0398	Pfam SNARE associated Golgi protein
M6D84_RS05810	COG0179	Fumarylacetoacetate (FAA) hydrolase
M6D84_RS05835	COG0367	asparagine synthase
M6D84_RS05845	COG0753	catalase activity
M6D84_RS05850	COG0004	ammonium transporteR
M6D84_RS05870	COG2996	Protein conserved in bacteria
M6D84_RS05885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_RS05900	COG0561	phosphatase activity
M6D84_RS05920	COG2267	carboxylic ester hydrolase activity
M6D84_RS05940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M6D84_RS05945	COG5504	Zn-dependent protease
M6D84_RS05955	COG0180	Tryptophanyl-tRNA synthetase
M6D84_RS05965	COG4166	transmembrane transport
M6D84_RS05970	COG0601	transmembrane transport
M6D84_RS05975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D84_RS05980	COG0444	Belongs to the ABC transporter superfamily
M6D84_RS05985	COG4608	Belongs to the ABC transporter superfamily
M6D84_RS05990	COG0534	Mate efflux family protein
M6D84_RS05995	COG4166	transmembrane transport
M6D84_RS06010	COG0861	Integral membrane protein TerC family
M6D84_RS06030	COG1164	Oligoendopeptidase f
M6D84_RS06045	COG2346	COG2346, Truncated hemoglobins
M6D84_RS06050	COG4116	CYTH
M6D84_RS06060	COG2357	RelA SpoT domain protein
M6D84_RS06070	COG0564	pseudouridine synthase activity
M6D84_RS06085	COG0772	Belongs to the SEDS family
M6D84_RS06090	COG1216	Glycosyl transferase, family 2
M6D84_RS06110	COG0457	Tetratricopeptide repeat
M6D84_RS06110	COG0463	Glycosyl transferase, family 2
M6D84_RS06130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M6D84_RS06145	COG1091	dTDP-4-dehydrorhamnose reductase activity
M6D84_RS06190	COG2153	protein acetylation
M6D84_RS06200	COG2382	esterase
M6D84_RS06225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6D84_RS06235	COG0512	Glutamine amidotransferase of anthranilate synthase
M6D84_RS06235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M6D84_RS06270	COG1620	l-lactate permease
M6D84_RS06275	COG5634	Uncharacterized conserved protein (DUF2278)
M6D84_RS06325	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6D84_RS06335	COG1476	TRANSCRIPTIONal
M6D84_RS06395	COG1686	Belongs to the peptidase S11 family
M6D84_RS06400	COG0681	Belongs to the peptidase S26 family
M6D84_RS06435	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_RS06445	COG1176	ABC-type spermidine putrescine transport system, permease component I
M6D84_RS06450	COG1177	transmembrane transport
M6D84_RS06465	COG2409	Drug exporters of the RND superfamily
M6D84_RS06475	COG0564	pseudouridine synthase activity
M6D84_RS06485	COG2340	Cysteine-rich secretory protein family
M6D84_RS06490	COG0247	lactate metabolic process
M6D84_RS06495	COG0277	FAD linked oxidase domain protein
M6D84_RS06500	COG3835	regulator
M6D84_RS06510	COG0745	RESPONSE REGULATOR receiver
M6D84_RS06515	COG5002	protein histidine kinase activity
M6D84_RS06520	COG2186	Transcriptional regulator
M6D84_RS06540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M6D84_RS06550	COG2116	formate transmembrane transporter activity
M6D84_RS06555	COG0861	Integral membrane protein TerC family
M6D84_RS06560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M6D84_RS06570	COG2030	dehydratase
M6D84_RS06590	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS06595	COG3243	poly(R)-hydroxyalkanoic acid synthase
M6D84_RS06605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M6D84_RS06620	COG1840	ABC-type Fe3 transport system, periplasmic component
M6D84_RS06625	COG3842	ATPase activity
M6D84_RS06650	COG1349	DNA-binding transcription factor activity
M6D84_RS06660	COG0235	Class ii aldolase
M6D84_RS06670	COG2861	carbohydrate metabolic process
M6D84_RS06680	COG3852	Histidine kinase
M6D84_RS06685	COG1846	Transcriptional regulator
M6D84_RS06695	COG2318	DinB family
M6D84_RS06705	COG5002	protein histidine kinase activity
M6D84_RS06715	COG0720	synthase
M6D84_RS06730	COG4873	Protein conserved in bacteria
M6D84_RS06755	COG1780	Probably involved in ribonucleotide reductase function
M6D84_RS06760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M6D84_RS06765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M6D84_RS06770	COG1725	Transcriptional regulator
M6D84_RS06775	COG1131	(ABC) transporter
M6D84_RS06785	COG1131	(ABC) transporter
M6D84_RS06790	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M6D84_RS06805	COG1522	sequence-specific DNA binding
M6D84_RS06815	COG1335	isochorismatase
M6D84_RS06825	COG1619	proteins homologs of microcin C7 resistance protein MccF
M6D84_RS06830	COG2070	2-Nitropropane dioxygenase
M6D84_RS06835	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M6D84_RS06845	COG1696	Membrane protein involved in D-alanine export
M6D84_RS06870	COG0716	FMN binding
M6D84_RS06925	COG1846	Transcriptional regulator
M6D84_RS06935	COG1301	dicarboxylic acid transport
M6D84_RS06940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M6D84_RS06945	COG4709	membrane
M6D84_RS06950	COG3874	Sporulation protein YtfJ
M6D84_RS06970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6D84_RS06975	COG0028	Belongs to the TPP enzyme family
M6D84_RS06980	COG0440	acetolactate synthase activity
M6D84_RS07055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M6D84_RS07070	COG1183	phosphatidylcholine synthase activity
M6D84_RS07075	COG1368	sulfuric ester hydrolase activity
M6D84_RS07085	COG0019	diaminopimelate decarboxylase activity
M6D84_RS07105	COG0529	Catalyzes the synthesis of activated sulfate
M6D84_RS07110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M6D84_RS07130	COG1648	precorrin-2 dehydrogenase activity
M6D84_RS07135	COG0733	neurotransmitter:sodium symporter activity
M6D84_RS07160	COG1757	Na H antiporter
M6D84_RS07175	COG4758	membrane
M6D84_RS07180	COG4585	Histidine kinase
M6D84_RS07185	COG2197	response regulator
M6D84_RS07195	COG1114	Component of the transport system for branched-chain amino acids
M6D84_RS07245	COG0730	response to heat
M6D84_RS07250	COG0306	phosphate transporter
M6D84_RS07255	COG1392	Phosphate transport regulator
M6D84_RS07260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D84_RS07275	COG3852	Histidine kinase
M6D84_RS07280	COG1801	Protein of unknown function DUF72
M6D84_RS07290	COG0582	viral genome integration into host DNA
M6D84_RS07295	COG5002	protein histidine kinase activity
M6D84_RS07310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M6D84_RS07310	COG0392	lysyltransferase activity
M6D84_RS07325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M6D84_RS07330	COG1686	Belongs to the peptidase S11 family
M6D84_RS07335	COG2715	membrane protein required for spore maturation
M6D84_RS07340	COG0700	Nucleoside recognition
M6D84_RS07345	COG1187	pseudouridine synthase activity
M6D84_RS07355	COG1333	cytochrome c biogenesis protein
M6D84_RS07360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M6D84_RS07365	COG0745	RESPONSE REGULATOR receiver
M6D84_RS07370	COG5002	protein histidine kinase activity
M6D84_RS07375	COG2096	Adenosyltransferase
M6D84_RS07390	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M6D84_RS07395	COG1141	Ferredoxin
M6D84_RS07405	COG0514	ATP-dependent DNA helicase (RecQ)
M6D84_RS07410	COG1266	CAAX protease self-immunity
M6D84_RS07420	COG1408	metallophosphoesterase
M6D84_RS07425	COG0789	Transcriptional regulator
M6D84_RS07435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M6D84_RS07455	COG0492	ferredoxin-NADP+ reductase activity
M6D84_RS07460	COG0252	asparaginase activity
M6D84_RS07530	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M6D84_RS07545	COG0142	geranyltranstransferase activity
M6D84_RS07555	COG0142	geranyltranstransferase activity
M6D84_RS07580	COG0457	Tetratricopeptide repeat
M6D84_RS07600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M6D84_RS07605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M6D84_RS07605	COG2010	Cytochrome c
M6D84_RS07610	COG4347	Protein of unknown function (DUF1405)
M6D84_RS07625	COG2738	Putative neutral zinc metallopeptidase
M6D84_RS07640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_RS07645	COG1694	Mazg nucleotide pyrophosphohydrolase
M6D84_RS07665	COG0438	transferase activity, transferring glycosyl groups
M6D84_RS07700	COG1199	ATP-dependent helicase activity
M6D84_RS07700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M6D84_RS07720	COG3935	DnaD domain protein
M6D84_RS07725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M6D84_RS07735	COG4499	WXG100 protein secretion system (Wss), protein YukC
M6D84_RS07735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D84_RS07790	COG0116	Belongs to the methyltransferase superfamily
M6D84_RS07810	COG0457	Tetratricopeptide repeat
M6D84_RS07830	COG1199	ATP-dependent helicase activity
M6D84_RS07835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M6D84_RS07845	COG0024	Methionine aminopeptidase
M6D84_RS07855	COG2233	PERMEase
M6D84_RS07860	COG2311	Membrane
M6D84_RS07865	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M6D84_RS07875	COG0456	acetyltransferase
M6D84_RS07925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6D84_RS07940	COG3944	biosynthesis protein
M6D84_RS07950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M6D84_RS07965	COG1215	transferase activity, transferring glycosyl groups
M6D84_RS07970	COG0438	transferase activity, transferring glycosyl groups
M6D84_RS07985	COG0454	-acetyltransferase
M6D84_RS08005	COG0328	RNA-DNA hybrid ribonuclease activity
M6D84_RS08040	COG3403	YqcI/YcgG family
M6D84_RS08045	COG1280	lysine exporter protein (LysE YggA)
M6D84_RS08065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6D84_RS08070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M6D84_RS08080	COG0475	glutathione-regulated potassium exporter activity
M6D84_RS08085	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M6D84_RS08090	COG0789	Transcriptional regulator
M6D84_RS08090	COG4978	Transcriptional regulator
M6D84_RS08100	COG2323	membrane
M6D84_RS08105	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M6D84_RS08155	COG1923	regulation of RNA biosynthetic process
M6D84_RS08165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M6D84_RS08170	COG1360	Flagellar Motor Protein
M6D84_RS08175	COG2201	protein-glutamate methylesterase activity
M6D84_RS08180	COG2198	Histidine kinase
M6D84_RS08180	COG0643	Histidine kinase
M6D84_RS08185	COG1776	CheC inhibitor of MCP methylation
M6D84_RS08185	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M6D84_RS08200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M6D84_RS08220	COG1256	bacterial-type flagellum assembly
M6D84_RS08225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M6D84_RS08245	COG1815	bacterial-type flagellum-dependent cell motility
M6D84_RS08250	COG1558	bacterial-type flagellum-dependent cell motility
M6D84_RS08260	COG1766	The M ring may be actively involved in energy transduction
M6D84_RS08265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M6D84_RS08275	COG1157	protein secretion by the type III secretion system
M6D84_RS08295	COG1749	Flagellar hook protein flgE
M6D84_RS08310	COG0784	Response regulator, receiver
M6D84_RS08310	COG0835	chemotaxis
M6D84_RS08325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M6D84_RS08330	COG0741	lytic transglycosylase activity
M6D84_RS08340	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M6D84_RS08345	COG1776	CheC inhibitor of MCP methylation
M6D84_RS08345	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M6D84_RS08355	COG1338	Plays a role in the flagellum-specific transport system
M6D84_RS08360	COG1987	bacterial-type flagellum assembly
M6D84_RS08370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M6D84_RS08375	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M6D84_RS08380	COG1419	protein localization to endoplasmic reticulum
M6D84_RS08385	COG4786	Flagellar basal body rod
M6D84_RS08390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M6D84_RS08425	COG2329	Antibiotic biosynthesis monooxygenase
M6D84_RS08450	COG0583	DNA-binding transcription factor activity
M6D84_RS08455	COG3842	ATPase activity
M6D84_RS08465	COG1177	transmembrane transport
M6D84_RS08470	COG1234	tRNA 3'-trailer cleavage
M6D84_RS08500	COG0406	alpha-ribazole phosphatase activity
M6D84_RS08530	COG0367	asparagine synthase
M6D84_RS08565	COG0697	spore germination
M6D84_RS08575	COG0523	cobalamin synthesis protein
M6D84_RS08580	COG0701	Predicted permease
M6D84_RS08595	COG1757	Na H antiporter
M6D84_RS08600	COG0789	Transcriptional regulator
M6D84_RS08630	COG0534	Mate efflux family protein
M6D84_RS08635	COG3340	Belongs to the peptidase S51 family
M6D84_RS08655	COG0785	Cytochrome C biogenesis protein
M6D84_RS08660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_RS08680	COG2733	membrane
M6D84_RS08715	COG1131	(ABC) transporter
M6D84_RS08735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M6D84_RS08740	COG0528	UMP kinase activity
M6D84_RS08750	COG1027	Aspartate ammonia-lyase
M6D84_RS08755	COG0281	malic enzyme
M6D84_RS08760	COG4191	Histidine kinase
M6D84_RS08765	COG0784	Response regulator, receiver
M6D84_RS08770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M6D84_RS08785	COG3620	sequence-specific DNA binding
M6D84_RS08820	COG2814	Major facilitator Superfamily
M6D84_RS08835	COG1695	Transcriptional regulator
M6D84_RS08850	COG0477	Major facilitator Superfamily
M6D84_RS08865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M6D84_RS08870	COG2223	nitrite transmembrane transporter activity
M6D84_RS08875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M6D84_RS08895	COG0733	neurotransmitter:sodium symporter activity
M6D84_RS08905	COG5566	PFAM Mor transcription activator
M6D84_RS08910	COG2323	membrane
M6D84_RS08930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M6D84_RS08940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6D84_RS08945	COG0028	Belongs to the TPP enzyme family
M6D84_RS08965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M6D84_RS08985	COG2814	Major facilitator Superfamily
M6D84_RS08990	COG3384	dioxygenase
M6D84_RS09000	COG3279	Response regulator of the LytR AlgR family
M6D84_RS09005	COG0427	acetyl-CoA hydrolase
M6D84_RS09025	COG4166	transmembrane transport
M6D84_RS09030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS09050	COG1914	H( )-stimulated, divalent metal cation uptake system
M6D84_RS09065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M6D84_RS09070	COG0531	amino acid
M6D84_RS09090	COG2309	aminopeptidase activity
M6D84_RS09105	COG0456	acetyltransferase
M6D84_RS09115	COG1266	CAAX protease self-immunity
M6D84_RS09120	COG1309	transcriptional regulator
M6D84_RS09125	COG2390	Transcriptional regulator
M6D84_RS09135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_RS09140	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M6D84_RS09155	COG4846	Membrane protein involved in cytochrome C biogenesis
M6D84_RS09165	COG0006	proline dipeptidase activity
M6D84_RS09175	COG2132	Multicopper oxidase
M6D84_RS09185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M6D84_RS09205	COG1114	Component of the transport system for branched-chain amino acids
M6D84_RS09215	COG2372	response to copper ion
M6D84_RS09215	COG1276	copper resistance
M6D84_RS09220	COG4549	nuclear export factor GLE1
M6D84_RS09225	COG0697	spore germination
M6D84_RS09230	COG0583	DNA-binding transcription factor activity
M6D84_RS09235	COG1959	2 iron, 2 sulfur cluster binding
M6D84_RS09240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M6D84_RS09245	COG0778	Nitroreductase
M6D84_RS09255	COG0628	permease
M6D84_RS09265	COG1231	oxidoreductase activity
M6D84_RS09270	COG0523	cobalamin synthesis protein
M6D84_RS09285	COG0411	ABC transporter
M6D84_RS09305	COG0583	DNA-binding transcription factor activity
M6D84_RS09340	COG1271	oxidase subunit
M6D84_RS09345	COG1294	oxidase, subunit
M6D84_RS09350	COG4988	ABC transporter
M6D84_RS09355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M6D84_RS09365	COG1216	Glycosyl transferase, family 2
M6D84_RS09405	COG1686	Belongs to the peptidase S11 family
M6D84_RS09420	COG0791	NLP P60 protein
M6D84_RS09420	COG1388	LysM domain
M6D84_RS09430	COG1132	(ABC) transporter
M6D84_RS09435	COG0745	RESPONSE REGULATOR receiver
M6D84_RS09440	COG5002	protein histidine kinase activity
M6D84_RS09445	COG0300	oxidoreductase activity
M6D84_RS09475	COG0460	homoserine dehydrogenase
M6D84_RS09500	COG1316	TRANSCRIPTIONal
M6D84_RS09510	COG0745	RESPONSE REGULATOR receiver
M6D84_RS09515	COG5002	protein histidine kinase activity
M6D84_RS09530	COG1285	pathogenesis
M6D84_RS09535	COG1247	-acetyltransferase
M6D84_RS09555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M6D84_RS09565	COG1082	Xylose isomerase domain protein TIM barrel
M6D84_RS09575	COG2814	Major facilitator Superfamily
M6D84_RS09580	COG1279	arginine transmembrane transporter activity
M6D84_RS09585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_RS09595	COG1752	Esterase of the alpha-beta hydrolase superfamily
M6D84_RS09630	COG0577	efflux transmembrane transporter activity
M6D84_RS09635	COG2002	toxin-antitoxin pair type II binding
M6D84_RS09640	COG1404	Belongs to the peptidase S8 family
M6D84_RS09645	COG0640	Transcriptional regulator
M6D84_RS09650	COG0667	Aldo Keto reductase
M6D84_RS09655	COG2814	Major facilitator Superfamily
M6D84_RS09660	COG3152	Membrane
M6D84_RS09685	COG0840	transmembrane signaling receptor activity
M6D84_RS09700	COG3949	Membrane
M6D84_RS09705	COG0783	Belongs to the Dps family
M6D84_RS09720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M6D84_RS09730	COG1231	oxidoreductase activity
M6D84_RS09735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS09740	COG4989	oxidoreductase activity
M6D84_RS09745	COG0523	cobalamin synthesis protein
M6D84_RS09750	COG0456	acetyltransferase
M6D84_RS09755	COG0803	Belongs to the bacterial solute-binding protein 9 family
M6D84_RS09765	COG0702	epimerase
M6D84_RS09775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M6D84_RS09785	COG4166	transmembrane transport
M6D84_RS09810	COG5337	Spore coat protein CotH
M6D84_RS09815	COG1051	belongs to the nudix hydrolase family
M6D84_RS09820	COG0586	Pfam SNARE associated Golgi protein
M6D84_RS09825	COG2244	polysaccharide biosynthetic process
M6D84_RS09835	COG0701	Predicted permease
M6D84_RS09840	COG3689	TIGRFAM TIGR03943 family protein
M6D84_RS09845	COG1607	acyl-coa hydrolase
M6D84_RS09855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M6D84_RS09870	COG0702	epimerase
M6D84_RS09875	COG2839	Protein conserved in bacteria
M6D84_RS09880	COG1253	flavin adenine dinucleotide binding
M6D84_RS09895	COG1114	Component of the transport system for branched-chain amino acids
M6D84_RS09900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M6D84_RS09920	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_RS09930	COG1876	peptidase activity
M6D84_RS09940	COG0154	amidase activity
M6D84_RS09945	COG2211	Major facilitator Superfamily
M6D84_RS09960	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_RS09970	COG0561	phosphatase activity
M6D84_RS09985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M6D84_RS10005	COG1819	glycosyl
M6D84_RS10010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_RS10015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_RS10045	COG0456	acetyltransferase
M6D84_RS10080	COG4499	WXG100 protein secretion system (Wss), protein YukC
M6D84_RS10170	COG3874	Sporulation protein YtfJ
M6D84_RS10195	COG2226	methyltransferase
M6D84_RS10225	COG0582	viral genome integration into host DNA
M6D84_RS10250	COG1396	sequence-specific DNA binding
M6D84_RS10285	COG2002	toxin-antitoxin pair type II binding
M6D84_RS10355	COG0582	viral genome integration into host DNA
M6D84_RS10475	COG5632	N-Acetylmuramoyl-L-alanine amidase
M6D84_RS10520	COG0604	alcohol dehydrogenase
M6D84_RS10525	COG1595	DNA-templated transcription, initiation
M6D84_RS10550	COG0386	Belongs to the glutathione peroxidase family
M6D84_RS10555	COG1305	Transglutaminase-like
M6D84_RS10560	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M6D84_RS10565	COG0714	Associated with various cellular activities
M6D84_RS10570	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M6D84_RS10575	COG1140	nitrate reductase beta subunit
M6D84_RS10580	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M6D84_RS10585	COG2181	nitrate reductase activity
M6D84_RS10590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M6D84_RS10595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M6D84_RS10600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M6D84_RS10605	COG0303	'Molybdopterin
M6D84_RS10610	COG0314	molybdopterin synthase activity
M6D84_RS10620	COG2223	nitrite transmembrane transporter activity
M6D84_RS10640	COG1648	precorrin-2 dehydrogenase activity
M6D84_RS10650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M6D84_RS10650	COG1587	Uroporphyrinogen-III synthase
M6D84_RS10655	COG2146	nitrite reductase [NAD(P)H] activity
M6D84_RS10660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M6D84_RS10665	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
M6D84_RS10700	COG2359	stage V sporulation protein S
M6D84_RS10725	COG0457	Tetratricopeptide repeat
M6D84_RS10740	COG1418	mRNA catabolic process
M6D84_RS10745	COG0488	(ABC) transporter
M6D84_RS10760	COG0629	single-stranded DNA binding
M6D84_RS10765	COG1413	lyase activity
M6D84_RS10780	COG2521	methyltransferase
M6D84_RS10780	COG2136	Putative SAM-dependent methyltransferase
M6D84_RS10785	COG0018	arginyl-trna synthetase
M6D84_RS10835	COG0017	Asparaginyl-tRNA synthetase
M6D84_RS10840	COG0733	neurotransmitter:sodium symporter activity
M6D84_RS10865	COG2610	gluconate transmembrane transporter activity
M6D84_RS10875	COG1794	racemase activity, acting on amino acids and derivatives
M6D84_RS10885	COG0456	acetyltransferase
M6D84_RS10895	COG3655	Transcriptional regulator
M6D84_RS10900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M6D84_RS10910	COG1131	(ABC) transporter
M6D84_RS10915	COG4473	ABC transporter
M6D84_RS10925	COG0546	phosphoglycolate phosphatase activity
M6D84_RS10940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_RS10955	COG0768	penicillin binding
M6D84_RS10965	COG0204	Acyl-transferase
M6D84_RS10970	COG1272	protein, Hemolysin III
M6D84_RS10980	COG0805	protein transport
M6D84_RS10990	COG1307	EDD domain protein, DegV family
M6D84_RS11000	COG1999	signal sequence binding
M6D84_RS11005	COG0071	Belongs to the small heat shock protein (HSP20) family
M6D84_RS11010	COG0367	asparagine synthase
M6D84_RS11025	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_RS11030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_RS11035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6D84_RS11050	COG1335	isochorismatase
M6D84_RS11065	COG0668	transmembrane transport
M6D84_RS11070	COG4585	Histidine kinase
M6D84_RS11070	COG2203	Gaf domain
M6D84_RS11075	COG2197	response regulator
M6D84_RS11080	COG1737	Transcriptional regulator
M6D84_RS11085	COG0384	phenazine biosynthesis protein PhzF
M6D84_RS11090	COG1064	alcohol dehydrogenase
M6D84_RS11115	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M6D84_RS11150	COG0517	IMP dehydrogenase activity
M6D84_RS11150	COG1125	glycine betaine transport
M6D84_RS11155	COG1174	glycine betaine transport
M6D84_RS11190	COG1253	flavin adenine dinucleotide binding
M6D84_RS11195	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_RS11200	COG5506	Protein of unknown function (DUF1694)
M6D84_RS11220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M6D84_RS11225	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M6D84_RS11230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M6D84_RS11235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M6D84_RS11240	COG0456	acetyltransferase
M6D84_RS11245	COG3829	transcription factor binding
M6D84_RS11250	COG1509	lysine 2,3-aminomutase activity
M6D84_RS11285	COG3064	Membrane
M6D84_RS11285	COG0515	serine threonine protein kinase
M6D84_RS11285	COG4991	sh3 domain protein
M6D84_RS11295	COG0671	phosphoesterase, PA-phosphatase related
M6D84_RS11300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M6D84_RS11305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_RS11395	COG0300	oxidoreductase activity
M6D84_RS11415	COG4499	WXG100 protein secretion system (Wss), protein YukC
M6D84_RS11415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D84_RS11425	COG2814	Major facilitator Superfamily
M6D84_RS11430	COG4841	protein insertion into membrane
M6D84_RS11435	COG0372	Belongs to the citrate synthase family
M6D84_RS11440	COG2079	MmgE PrpD family protein
M6D84_RS11445	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M6D84_RS11450	COG1960	acyl-CoA dehydrogenase activity
M6D84_RS11455	COG2084	Dehydrogenase
M6D84_RS11465	COG1280	lysine exporter protein (LysE YggA)
M6D84_RS11470	COG1024	Enoyl-CoA hydratase
M6D84_RS11485	COG0420	3'-5' exonuclease activity
M6D84_RS11490	COG0419	ATPase involved in DNA repair
M6D84_RS11515	COG2223	nitrite transmembrane transporter activity
M6D84_RS11520	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS11525	COG1169	isochorismate synthase
M6D84_RS11530	COG1021	2,3-dihydroxybenzoate-AMP ligase
M6D84_RS11535	COG3433	isochorismatase activity
M6D84_RS11535	COG1535	isochorismatase
M6D84_RS11540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M6D84_RS11545	COG3251	PFAM MbtH domain protein
M6D84_RS11550	COG2814	Major facilitator Superfamily
M6D84_RS11565	COG0776	regulation of translation
M6D84_RS11575	COG2318	DinB family
M6D84_RS11585	COG1115	amino acid carrier protein
M6D84_RS11605	COG1187	pseudouridine synthase activity
M6D84_RS11610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M6D84_RS11615	COG1136	(ABC) transporter
M6D84_RS11640	COG0028	Belongs to the TPP enzyme family
M6D84_RS11680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M6D84_RS11705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_RS11735	COG1247	-acetyltransferase
M6D84_RS11760	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M6D84_RS11770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS11800	COG0583	DNA-binding transcription factor activity
M6D84_RS11805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M6D84_RS11825	COG0583	DNA-binding transcription factor activity
M6D84_RS11830	COG2258	MOSC domain
M6D84_RS11845	COG1132	(ABC) transporter
M6D84_RS11850	COG1132	(ABC) transporter
M6D84_RS11880	COG1396	sequence-specific DNA binding
M6D84_RS11910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M6D84_RS11915	COG1595	DNA-templated transcription, initiation
M6D84_RS11940	COG1649	PFAM Uncharacterised BCR, COG1649
M6D84_RS11965	COG2971	BadF BadG BcrA BcrD
M6D84_RS11985	COG1846	Transcriptional regulator
M6D84_RS12000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_RS12020	COG1309	transcriptional regulator
M6D84_RS12035	COG0582	viral genome integration into host DNA
M6D84_RS12060	COG3011	Protein conserved in bacteria
M6D84_RS12095	COG0582	viral genome integration into host DNA
M6D84_RS12130	COG0500	methyltransferase
M6D84_RS12130	COG3615	Tellurite resistance protein tehB
M6D84_RS12140	COG2226	methyltransferase
M6D84_RS12145	COG3961	Belongs to the TPP enzyme family
M6D84_RS12150	COG1846	Transcriptional regulator
M6D84_RS12180	COG2195	Cleaves the N-terminal amino acid of tripeptides
M6D84_RS12210	COG2002	toxin-antitoxin pair type II binding
M6D84_RS12225	COG0730	response to heat
M6D84_RS12230	COG0110	maltose O-acetyltransferase activity
M6D84_RS12235	COG1686	Belongs to the peptidase S11 family
M6D84_RS12250	COG2814	Major facilitator Superfamily
M6D84_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS12310	COG0741	lytic transglycosylase activity
M6D84_RS12315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS12370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_RS12375	COG0768	penicillin binding
M6D84_RS12380	COG1595	DNA-templated transcription, initiation
M6D84_RS12390	COG0768	penicillin binding
M6D84_RS12395	COG0768	penicillin binding
M6D84_RS12405	COG1408	metallophosphoesterase
M6D84_RS12415	COG1131	(ABC) transporter
M6D84_RS12425	COG1309	transcriptional regulator
M6D84_RS12440	COG1960	acyl-CoA dehydrogenase activity
M6D84_RS12445	COG0439	Biotin carboxylase
M6D84_RS12450	COG0511	ligase activity, forming carbon-carbon bonds
M6D84_RS12455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M6D84_RS12460	COG1024	Enoyl-CoA hydratase
M6D84_RS12465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M6D84_RS12470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M6D84_RS12490	COG0572	uridine kinase
M6D84_RS12510	COG1686	Belongs to the peptidase S11 family
M6D84_RS12535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M6D84_RS12550	COG3227	Zinc metalloprotease (Elastase)
M6D84_RS12555	COG2207	Transcriptional regulator
M6D84_RS12585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M6D84_RS12595	COG2814	Major facilitator Superfamily
M6D84_RS12600	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS12605	COG1733	regulation of RNA biosynthetic process
M6D84_RS12650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_RS12660	COG2368	4-hydroxyphenylacetate
M6D84_RS12675	COG1063	alcohol dehydrogenase
M6D84_RS12685	COG2323	membrane
M6D84_RS12700	COG3386	PFAM SMP-30 Gluconolaconase
M6D84_RS12715	COG3773	Cell wall hydrolase
M6D84_RS12725	COG0745	RESPONSE REGULATOR receiver
M6D84_RS12730	COG2205	protein histidine kinase activity
M6D84_RS12740	COG0488	(ABC) transporter
M6D84_RS12755	COG0825	malonyl-CoA metabolic process
M6D84_RS12765	COG1136	(ABC) transporter
M6D84_RS12770	COG0577	efflux transmembrane transporter activity
M6D84_RS12790	COG0460	homoserine dehydrogenase
M6D84_RS12795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_RS12805	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M6D84_RS12865	COG2124	cytochrome p450
M6D84_RS12900	COG0561	phosphatase activity
M6D84_RS12905	COG5002	protein histidine kinase activity
M6D84_RS12910	COG0768	penicillin binding
M6D84_RS12920	COG1819	glycosyl
M6D84_RS12925	COG1794	racemase activity, acting on amino acids and derivatives
M6D84_RS12950	COG2205	protein histidine kinase activity
M6D84_RS12955	COG0582	viral genome integration into host DNA
M6D84_RS13005	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M6D84_RS13010	COG0604	alcohol dehydrogenase
M6D84_RS13015	COG0671	phosphoesterase, PA-phosphatase related
M6D84_RS13020	COG0768	penicillin binding
M6D84_RS13075	COG2814	Major facilitator Superfamily
M6D84_RS13080	COG4978	Transcriptional regulator
M6D84_RS13080	COG0789	Transcriptional regulator
M6D84_RS13100	COG0584	glycerophosphoryl diester phosphodiesterase
M6D84_RS13120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_RS13125	COG0697	spore germination
M6D84_RS13160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_RS13170	COG2223	nitrite transmembrane transporter activity
M6D84_RS13185	COG0592	DNA-directed DNA polymerase activity
M6D84_RS13205	COG3878	Protein conserved in bacteria
M6D84_RS13215	COG3507	Belongs to the glycosyl hydrolase 43 family
M6D84_RS13215	COG2382	esterase
M6D84_RS13215	COG3693	PFAM glycoside hydrolase, family 10
M6D84_RS13230	COG4667	esterase of the alpha-beta hydrolase superfamily
M6D84_RS13270	COG0322	excinuclease ABC activity
M6D84_RS13310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D84_RS13340	COG1011	Hydrolase
M6D84_RS13345	COG0745	RESPONSE REGULATOR receiver
M6D84_RS13350	COG5002	protein histidine kinase activity
M6D84_RS13365	COG1136	(ABC) transporter
M6D84_RS13370	COG0577	efflux transmembrane transporter activity
M6D84_RS13375	COG1073	alpha beta
M6D84_RS13380	COG0657	acetylesterase activity
M6D84_RS13385	COG0076	glutamate decarboxylase activity
M6D84_RS13400	COG1523	belongs to the glycosyl hydrolase 13 family
M6D84_RS13405	COG3227	Zinc metalloprotease (Elastase)
M6D84_RS13410	COG0737	Belongs to the 5'-nucleotidase family
M6D84_RS13425	COG0201	protein transport
M6D84_RS13430	COG0697	spore germination
M6D84_RS13435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_RS13475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS13490	COG2959	enzyme of heme biosynthesis
M6D84_RS13530	COG1309	transcriptional regulator
M6D84_RS13560	COG3284	Transcriptional regulator
M6D84_RS13575	COG1349	DNA-binding transcription factor activity
M6D84_RS13590	COG1959	2 iron, 2 sulfur cluster binding
M6D84_RS13605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M6D84_RS13610	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6D84_RS13615	COG0022	dehydrogenase e1 component
M6D84_RS13620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M6D84_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS13635	COG0456	acetyltransferase
M6D84_RS13635	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M6D84_RS13675	COG4176	ABC-type proline glycine betaine transport system permease component
M6D84_RS13680	COG0517	IMP dehydrogenase activity
M6D84_RS13680	COG4175	Glycine betaine
M6D84_RS13710	COG2153	protein acetylation
M6D84_RS13715	COG3397	chitin binding
M6D84_RS13720	COG1819	glycosyl
M6D84_RS13740	COG2205	protein histidine kinase activity
M6D84_RS13745	COG2226	methyltransferase
M6D84_RS13750	COG2315	Protein conserved in bacteria
M6D84_RS13795	COG3973	AAA domain
M6D84_RS13805	COG2105	PFAM AIG2 family protein
M6D84_RS13810	COG0514	ATP-dependent DNA helicase (RecQ)
M6D84_RS13845	COG4637	Psort location Cytoplasmic, score
M6D84_RS13860	COG3397	chitin binding
M6D84_RS13875	COG1162	GTPase activity
M6D84_RS13880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M6D84_RS13885	COG1115	amino acid carrier protein
M6D84_RS13890	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_RS13895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M6D84_RS13905	COG3938	Belongs to the proline racemase family
M6D84_RS13910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D84_RS13955	COG1078	dGTPase activity
M6D84_RS13960	COG0586	Pfam SNARE associated Golgi protein
M6D84_RS13970	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M6D84_RS13980	COG4166	transmembrane transport
M6D84_RS13990	COG4948	Mandelate Racemase Muconate Lactonizing
M6D84_RS14005	COG0667	Aldo Keto reductase
M6D84_RS14050	COG3850	Histidine kinase
M6D84_RS14050	COG5002	protein histidine kinase activity
M6D84_RS14055	COG0745	RESPONSE REGULATOR receiver
M6D84_RS14095	COG1164	Oligoendopeptidase f
M6D84_RS14100	COG1307	EDD domain protein, DegV family
M6D84_RS14140	COG2814	Major facilitator Superfamily
M6D84_RS14150	COG1664	Polymer-forming cytoskeletal
M6D84_RS14155	COG0789	Transcriptional regulator
M6D84_RS14160	COG4533	DNA binding
M6D84_RS14165	COG2814	Major facilitator Superfamily
M6D84_RS14165	COG0477	Major facilitator Superfamily
M6D84_RS14185	COG2261	transglycosylase associated protein
M6D84_RS14235	COG0436	Aminotransferase
M6D84_RS14240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M6D84_RS14250	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M6D84_RS14290	COG0628	permease
M6D84_RS14305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M6D84_RS14310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D84_RS14315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M6D84_RS14355	COG2746	aminoglycoside 3-N-acetyltransferase activity
M6D84_RS14365	COG0697	spore germination
M6D84_RS14375	COG2318	DinB family
M6D84_RS14395	COG4912	Dna alkylation repair
M6D84_RS14400	COG0346	lactoylglutathione lyase activity
M6D84_RS14415	COG0861	Integral membrane protein TerC family
M6D84_RS14420	COG1368	sulfuric ester hydrolase activity
M6D84_RS14425	COG0488	(ABC) transporter
M6D84_RS14430	COG1033	growth of symbiont in host cell
M6D84_RS14430	COG2409	Drug exporters of the RND superfamily
M6D84_RS14435	COG1309	transcriptional regulator
M6D84_RS14450	COG0287	Prephenate dehydrogenase
M6D84_RS14465	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M6D84_RS14465	COG1605	Chorismate mutase
M6D84_RS14510	COG1388	LysM domain
M6D84_RS14510	COG3584	3D domain protein
M6D84_RS14530	COG0277	FAD linked oxidase domain protein
M6D84_RS14535	COG0477	Major facilitator Superfamily
M6D84_RS14540	COG1309	transcriptional regulator
M6D84_RS14550	COG1595	DNA-templated transcription, initiation
M6D84_RS14580	COG1172	Belongs to the binding-protein-dependent transport system permease family
M6D84_RS14585	COG1172	Belongs to the binding-protein-dependent transport system permease family
M6D84_RS14595	COG2390	Transcriptional regulator
M6D84_RS14600	COG1070	Carbohydrate kinase
M6D84_RS14625	COG2329	Antibiotic biosynthesis monooxygenase
M6D84_RS14645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_RS14660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M6D84_RS14665	COG4187	Peptidase family M20/M25/M40
M6D84_RS14670	COG1414	Transcriptional regulator
M6D84_RS14675	COG0833	amino acid
M6D84_RS14685	COG3239	Fatty acid desaturase
M6D84_RS14695	COG2720	vancomycin resistance protein
M6D84_RS14700	COG1785	Belongs to the alkaline phosphatase family
M6D84_RS14710	COG3655	Transcriptional regulator
M6D84_RS14730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS14735	COG0346	lactoylglutathione lyase activity
M6D84_RS14760	COG0714	Associated with various cellular activities
M6D84_RS14790	COG0463	Glycosyl transferase, family 2
M6D84_RS14820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M6D84_RS14825	COG0753	catalase activity
M6D84_RS14865	COG0714	Associated with various cellular activities
M6D84_RS14925	COG0778	Nitroreductase
M6D84_RS14930	COG1846	Transcriptional regulator
M6D84_RS14975	COG0456	acetyltransferase
M6D84_RS14990	COG0697	spore germination
M6D84_RS14995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_RS15010	COG0642	Histidine kinase
M6D84_RS15015	COG0745	RESPONSE REGULATOR receiver
M6D84_RS15020	COG0596	Alpha beta hydrolase
M6D84_RS15055	COG0730	response to heat
M6D84_RS15065	COG0833	amino acid
M6D84_RS15075	COG4335	DNA alkylation repair
M6D84_RS15085	COG5002	protein histidine kinase activity
M6D84_RS15090	COG0745	RESPONSE REGULATOR receiver
M6D84_RS15100	COG0577	efflux transmembrane transporter activity
M6D84_RS15100	COG1136	(ABC) transporter
M6D84_RS15130	COG0768	penicillin binding
M6D84_RS15160	COG1984	allophanate hydrolase subunit 2
M6D84_RS15165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M6D84_RS15170	COG1414	Transcriptional regulator
M6D84_RS15185	COG0640	Transcriptional regulator
M6D84_RS15195	COG1960	acyl-CoA dehydrogenase activity
M6D84_RS15210	COG3314	Sporulation integral membrane protein YlbJ
M6D84_RS15230	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M6D84_RS15255	COG0574	Belongs to the PEP-utilizing enzyme family
M6D84_RS15255	COG3848	Pyruvate phosphate dikinase
M6D84_RS15260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_RS15280	COG1063	alcohol dehydrogenase
M6D84_RS15285	COG1027	Aspartate ammonia-lyase
M6D84_RS15290	COG0252	asparaginase activity
M6D84_RS15295	COG1396	sequence-specific DNA binding
M6D84_RS15320	COG5002	protein histidine kinase activity
M6D84_RS15345	COG2207	Transcriptional regulator
M6D84_RS15360	COG0322	excinuclease ABC activity
M6D84_RS15365	COG0531	amino acid
M6D84_RS15370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M6D84_RS15380	COG0531	amino acid
M6D84_RS15385	COG0697	spore germination
M6D84_RS15390	COG0784	Response regulator, receiver
M6D84_RS15395	COG4191	Histidine kinase
M6D84_RS15400	COG2066	Belongs to the glutaminase family
M6D84_RS15405	COG1115	amino acid carrier protein
M6D84_RS15430	COG0737	Belongs to the 5'-nucleotidase family
M6D84_RS15435	COG2267	carboxylic ester hydrolase activity
M6D84_RS15440	COG1335	isochorismatase
M6D84_RS15460	COG0583	DNA-binding transcription factor activity
M6D84_RS15465	COG1846	Transcriptional regulator
M6D84_RS15485	COG0598	Magnesium transport protein CorA
M6D84_RS15505	COG1073	alpha beta
M6D84_RS15525	COG0415	Belongs to the DNA photolyase family
M6D84_RS15535	COG2814	Major facilitator Superfamily
M6D84_RS15545	COG0657	acetylesterase activity
M6D84_RS15550	COG0288	reversible hydration of carbon dioxide
M6D84_RS15560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M6D84_RS15565	COG5609	conserved protein (DUF2294)
M6D84_RS15575	COG0456	acetyltransferase
M6D84_RS15580	COG1575	Belongs to the MenA family. Type 1 subfamily
M6D84_RS15605	COG0798	PFAM Bile acid sodium symporter
M6D84_RS15610	COG0346	lactoylglutathione lyase activity
M6D84_RS15615	COG0640	Transcriptional regulator
M6D84_RS15625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M6D84_RS15635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M6D84_RS15635	COG3320	Male sterility
M6D84_RS15640	COG1309	transcriptional regulator
M6D84_RS15655	COG0346	lactoylglutathione lyase activity
M6D84_RS15680	COG0745	RESPONSE REGULATOR receiver
M6D84_RS15685	COG5002	protein histidine kinase activity
M6D84_RS15685	COG3850	Histidine kinase
M6D84_RS15720	COG0277	FAD linked oxidase domain protein
M6D84_RS15730	COG1136	(ABC) transporter
M6D84_RS15770	COG2814	Major facilitator Superfamily
M6D84_RS15785	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M6D84_RS15805	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M6D84_RS15825	COG0577	efflux transmembrane transporter activity
M6D84_RS15845	COG5002	protein histidine kinase activity
M6D84_RS15845	COG3850	Histidine kinase
M6D84_RS15855	COG2364	Membrane
M6D84_RS15860	COG1846	Transcriptional regulator
M6D84_RS15865	COG0456	acetyltransferase
M6D84_RS15870	COG2808	Putative FMN-binding domain
M6D84_RS15875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_RS15905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M6D84_RS15945	COG3409	Peptidoglycan-binding domain 1 protein
M6D84_RS15945	COG5632	N-Acetylmuramoyl-L-alanine amidase
M6D84_RS15995	COG5444	nuclease activity
M6D84_RS16050	COG1876	peptidase activity
M6D84_RS16055	COG2843	Capsule synthesis protein
M6D84_RS16065	COG0477	Major facilitator Superfamily
M6D84_RS16080	COG1846	Transcriptional regulator
M6D84_RS16085	COG2814	Major facilitator Superfamily
M6D84_RS16095	COG2031	fatty acid transporter
M6D84_RS16105	COG2249	NAD(P)H dehydrogenase (quinone) activity
M6D84_RS16160	COG1288	antiporter activity
M6D84_RS16165	COG2356	endonuclease I
M6D84_RS16185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M6D84_RS16205	COG1733	regulation of RNA biosynthetic process
M6D84_RS16210	COG0778	Nitroreductase
M6D84_RS16220	COG0469	pyruvate kinase activity
M6D84_RS16240	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS16250	COG1131	(ABC) transporter
M6D84_RS16275	COG1011	Hydrolase
M6D84_RS16280	COG2365	Tyrosine phosphatase family
M6D84_RS16315	COG0628	permease
M6D84_RS16345	COG0500	methyltransferase
M6D84_RS16385	COG1253	flavin adenine dinucleotide binding
M6D84_RS16390	COG0789	Transcriptional regulator
M6D84_RS16400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M6D84_RS16425	COG0697	spore germination
M6D84_RS16435	COG1357	PFAM Pentapeptide repeats (8 copies)
M6D84_RS16440	COG3813	Protein conserved in bacteria
M6D84_RS16445	COG2706	6-phosphogluconolactonase activity
M6D84_RS16450	COG1070	Carbohydrate kinase
M6D84_RS16460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M6D84_RS16465	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M6D84_RS16470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M6D84_RS16475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M6D84_RS16510	COG0814	amino acid
M6D84_RS16540	COG2188	Transcriptional regulator
M6D84_RS16545	COG0673	inositol 2-dehydrogenase activity
M6D84_RS16565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_RS16590	COG0384	phenazine biosynthesis protein PhzF
M6D84_RS16600	COG0318	PFAM AMP-dependent synthetase and ligase
M6D84_RS16605	COG2249	NAD(P)H dehydrogenase (quinone) activity
M6D84_RS16610	COG1733	regulation of RNA biosynthetic process
M6D84_RS16635	COG1191	sigma factor activity
M6D84_RS16695	COG3209	COG3209 Rhs family protein
M6D84_RS16705	COG1151	hydroxylamine reductase activity
M6D84_RS16735	COG2072	flavoprotein involved in K transport
M6D84_RS16770	COG1113	amino acid transport
M6D84_RS16775	COG2814	Major facilitator Superfamily
M6D84_RS16810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M6D84_RS16815	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M6D84_RS16825	COG1247	-acetyltransferase
M6D84_RS16830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_RS16835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_RS16840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_RS16845	COG3739	integral membrane protein
M6D84_RS16870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS16885	COG0583	DNA-binding transcription factor activity
M6D84_RS16905	COG1193	negative regulation of DNA recombination
M6D84_RS16915	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M6D84_RS16920	COG1164	Oligoendopeptidase f
M6D84_RS16955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_RS16980	COG0584	glycerophosphoryl diester phosphodiesterase
M6D84_RS16990	COG0640	Transcriptional regulator
M6D84_RS16995	COG0604	alcohol dehydrogenase
M6D84_RS17005	COG0457	Tetratricopeptide repeat
M6D84_RS17020	COG0277	FAD linked oxidase domain protein
M6D84_RS17045	COG1183	phosphatidylcholine synthase activity
M6D84_RS17050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_RS17050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_RS17055	COG1252	NADH dehydrogenase
M6D84_RS17065	COG0823	Involved in the tonB-independent uptake of proteins
M6D84_RS17070	COG3397	chitin binding
M6D84_RS17080	COG0697	spore germination
M6D84_RS17100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M6D84_RS17110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M6D84_RS17120	COG0457	Tetratricopeptide repeat
M6D84_RS17180	COG0488	(ABC) transporter
M6D84_RS17210	COG3852	Histidine kinase
M6D84_RS17220	COG1285	pathogenesis
M6D84_RS17230	COG2514	catechol 2,3-dioxygenase activity
M6D84_RS17235	COG2720	vancomycin resistance protein
M6D84_RS17270	COG0716	FMN binding
M6D84_RS17280	COG0494	nUDIX hydrolase
M6D84_RS17300	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS17310	COG0165	Argininosuccinate lyase
M6D84_RS17325	COG4145	pantothenate transmembrane transporter activity
M6D84_RS17335	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_RS17340	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS17350	COG1657	PFAM Prenyltransferase squalene oxidase
M6D84_RS17355	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M6D84_RS17360	COG2962	Rard protein
M6D84_RS17365	COG3326	Membrane
M6D84_RS17380	COG0489	protein tyrosine kinase activity
M6D84_RS17390	COG0314	molybdopterin synthase activity
M6D84_RS17395	COG0303	'Molybdopterin
M6D84_RS17400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M6D84_RS17405	COG2116	formate transmembrane transporter activity
M6D84_RS17415	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M6D84_RS17420	COG5609	conserved protein (DUF2294)
M6D84_RS17425	COG2427	Protein of unknown function (DUF1641)
M6D84_RS17430	COG3383	formate dehydrogenase (NAD+) activity
M6D84_RS17435	COG0697	spore germination
M6D84_RS17450	COG0531	amino acid
M6D84_RS17485	COG2226	methyltransferase
M6D84_RS17490	COG4166	transmembrane transport
M6D84_RS17495	COG4166	transmembrane transport
M6D84_RS17500	COG4166	transmembrane transport
M6D84_RS17505	COG1301	dicarboxylic acid transport
M6D84_RS17510	COG1316	TRANSCRIPTIONal
M6D84_RS17520	COG1595	DNA-templated transcription, initiation
M6D84_RS17530	COG1131	(ABC) transporter
M6D84_RS17540	COG0673	inositol 2-dehydrogenase activity
M6D84_RS17545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M6D84_RS17550	COG0187	DNA topoisomerase II activity
M6D84_RS17555	COG1832	CoA-binding protein
M6D84_RS17560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M6D84_RS17565	COG0745	RESPONSE REGULATOR receiver
M6D84_RS17585	COG4841	protein insertion into membrane
M6D84_RS17590	COG0824	Thioesterase
M6D84_RS17620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_RS17635	COG1132	(ABC) transporter
M6D84_RS17640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M6D84_RS17670	COG2211	Major facilitator Superfamily
M6D84_RS17680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M6D84_RS17695	COG0183	Belongs to the thiolase family
M6D84_RS17700	COG0318	PFAM AMP-dependent synthetase and ligase
M6D84_RS17705	COG1268	BioY protein
M6D84_RS17710	COG0318	PFAM AMP-dependent synthetase and ligase
M6D84_RS17755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_RS17765	COG5002	protein histidine kinase activity
M6D84_RS17770	COG0400	carboxylic ester hydrolase activity
M6D84_RS17775	COG0346	lactoylglutathione lyase activity
M6D84_RS17780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6D84_RS17790	COG0069	glutamate synthase activity
M6D84_RS17795	COG1902	pentaerythritol trinitrate reductase activity
M6D84_RS17800	COG1329	Transcriptional regulator
M6D84_RS17805	COG0010	Belongs to the arginase family
M6D84_RS17855	COG4846	Membrane protein involved in cytochrome C biogenesis
M6D84_RS17860	COG0785	Cytochrome C biogenesis protein
M6D84_RS17870	COG1473	amidohydrolase
M6D84_RS17880	COG1131	(ABC) transporter
M6D84_RS17895	COG0583	DNA-binding transcription factor activity
M6D84_RS17905	COG1346	cytolysis
M6D84_RS17920	COG0730	response to heat
M6D84_RS17945	COG1132	(ABC) transporter
M6D84_RS17950	COG1132	(ABC) transporter
M6D84_RS17975	COG3639	organic phosphonate transmembrane transporter activity
M6D84_RS17985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_RS17990	COG0737	Belongs to the 5'-nucleotidase family
M6D84_RS18000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M6D84_RS18020	COG1695	Transcriptional regulator
M6D84_RS18030	COG3409	Peptidoglycan-binding domain 1 protein
M6D84_RS18030	COG5632	N-Acetylmuramoyl-L-alanine amidase
M6D84_RS18030	COG1388	LysM domain
M6D84_RS18035	COG0739	heme binding
M6D84_RS18040	COG0741	lytic transglycosylase activity
M6D84_RS18070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M6D84_RS18075	COG0174	glutamine synthetase
M6D84_RS18080	COG0789	Transcriptional regulator
M6D84_RS18085	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M6D84_RS18090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M6D84_RS18095	COG2860	membrane
M6D84_RS18105	COG0464	growth
M6D84_RS18135	COG3584	3D domain protein
M6D84_RS18135	COG1388	LysM domain
M6D84_RS18140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M6D84_RS18140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M6D84_RS18140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6D84_RS18145	COG1105	Belongs to the carbohydrate kinase PfkB family
M6D84_RS18150	COG1349	DNA-binding transcription factor activity
M6D84_RS18155	COG1979	alcohol dehydrogenase
M6D84_RS18160	COG2322	membrane
M6D84_RS18170	COG1113	amino acid transport
M6D84_RS18180	COG1408	metallophosphoesterase
M6D84_RS18185	COG2116	formate transmembrane transporter activity
M6D84_RS18200	COG2217	Heavy metal translocating P-type atpase
M6D84_RS18205	COG2608	mercury ion transmembrane transporter activity
M6D84_RS18210	COG1937	Protein conserved in bacteria
M6D84_RS18220	COG2819	hydrolase of the alpha beta superfamily
M6D84_RS18225	COG1120	ATPase activity
M6D84_RS18230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_RS18235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_RS18240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_RS18250	COG2169	Transcriptional regulator
M6D84_RS18255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M6D84_RS18260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M6D84_RS18280	COG2267	carboxylic ester hydrolase activity
M6D84_RS18285	COG3300	MHYT domain
M6D84_RS18285	COG5001	Diguanylate cyclase
M6D84_RS18325	COG1346	cytolysis
M6D84_RS18335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_RS18345	COG2188	Transcriptional regulator
M6D84_RS18350	COG2723	6-phospho-beta-galactosidase activity
M6D84_RS18360	COG1404	Belongs to the peptidase S8 family
M6D84_RS18365	COG3773	Cell wall hydrolase
M6D84_RS18375	COG1368	sulfuric ester hydrolase activity
M6D84_RS18380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M6D84_RS18405	COG4550	Control of competence regulator ComK, YlbF/YmcA
M6D84_RS18415	COG1013	pyruvate-flavodoxin oxidoreductase activity
M6D84_RS18420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M6D84_RS18420	COG0674	pyruvate-flavodoxin oxidoreductase activity
M6D84_RS18430	COG2359	stage V sporulation protein S
M6D84_RS18435	COG1692	metallophosphoesterase
M6D84_RS18455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M6D84_RS18460	COG1426	Protein conserved in bacteria
M6D84_RS18475	COG0300	oxidoreductase activity
M6D84_RS18480	COG0612	Peptidase, M16
M6D84_RS18485	COG0612	Peptidase, M16
M6D84_RS18490	COG1079	Belongs to the binding-protein-dependent transport system permease family
M6D84_RS18495	COG4603	Belongs to the binding-protein-dependent transport system permease family
M6D84_RS18500	COG3845	ABC transporter
M6D84_RS18505	COG1744	ABC transporter substrate-binding protein PnrA-like
M6D84_RS18510	COG2188	Transcriptional regulator
M6D84_RS18530	COG0740	serine-type endopeptidase activity
M6D84_RS18535	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M6D84_RS18545	COG0527	aspartate kinase activity
M6D84_RS18550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M6D84_RS18575	COG4824	toxin secretion phage lysis holin
M6D84_RS18695	COG0582	viral genome integration into host DNA
M6D84_RS18715	COG1192	Involved in chromosome partitioning
M6D84_RS18735	COG0305	Participates in initiation and elongation during chromosome replication
M6D84_RS18800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M6D84_RS18805	COG1873	PFAM PRC-barrel domain
M6D84_RS18810	COG0612	Peptidase, M16
M6D84_RS18815	COG0726	polysaccharide deacetylase
M6D84_RS18830	COG0196	riboflavin kinase activity
M6D84_RS18840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M6D84_RS18845	COG1550	Protein conserved in bacteria
M6D84_RS18855	COG1358	cellular component organization or biogenesis
M6D84_RS18860	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M6D84_RS18865	COG0195	Participates in both transcription termination and antitermination
M6D84_RS18885	COG0750	zinc metalloprotease
M6D84_RS18895	COG4589	Belongs to the CDS family
M6D84_RS18940	COG4974	Belongs to the 'phage' integrase family
M6D84_RS18950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M6D84_RS18955	COG0758	DNA mediated transformation
M6D84_RS18960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M6D84_RS19000	COG1837	Belongs to the UPF0109 family
M6D84_RS19010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M6D84_RS19020	COG0552	protein localization to endoplasmic reticulum
M6D84_RS19025	COG1196	nuclear chromosome segregation
M6D84_RS19035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M6D84_RS19040	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS19045	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M6D84_RS19060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M6D84_RS19065	COG1461	Dihydroxyacetone kinase
M6D84_RS19070	COG1302	Protein conserved in bacteria
M6D84_RS19085	COG1564	THIamine pyrophosphokinase
M6D84_RS19090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M6D84_RS19100	COG2815	serine threonine protein kinase
M6D84_RS19100	COG0515	serine threonine protein kinase
M6D84_RS19105	COG0631	protein serine/threonine phosphatase activity
M6D84_RS19115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M6D84_RS19115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M6D84_RS19130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M6D84_RS19135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M6D84_RS19155	COG1561	YicC-like family, N-terminal region
M6D84_RS19160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M6D84_RS19170	COG0006	proline dipeptidase activity
M6D84_RS19185	COG3069	C4-dicarboxylate transmembrane transporter activity
M6D84_RS19245	COG0564	pseudouridine synthase activity
M6D84_RS19265	COG3599	regulation of cell shape
M6D84_RS19270	COG2302	S4 RNA-binding domain
M6D84_RS19275	COG0762	integral membrane protein
M6D84_RS19285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M6D84_RS19295	COG1873	PFAM PRC-barrel domain
M6D84_RS19300	COG1191	sigma factor activity
M6D84_RS19305	COG1191	sigma factor activity
M6D84_RS19315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M6D84_RS19320	COG0849	cell division
M6D84_RS19340	COG0772	Belongs to the SEDS family
M6D84_RS19360	COG0768	penicillin binding
M6D84_RS19365	COG0768	penicillin binding
M6D84_RS19385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M6D84_RS19400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M6D84_RS19405	COG1399	metal-binding, possibly nucleic acid-binding protein
M6D84_RS19415	COG3480	Lon protease (S16) C-terminal proteolytic domain
M6D84_RS19420	COG1752	Esterase of the alpha-beta hydrolase superfamily
M6D84_RS19425	COG3314	Sporulation integral membrane protein YlbJ
M6D84_RS19435	COG0742	ribosomal rna small subunit methyltransferase
M6D84_RS19450	COG3679	Belongs to the UPF0342 family
M6D84_RS19455	COG0406	alpha-ribazole phosphatase activity
M6D84_RS19470	COG2340	Cysteine-rich secretory protein family
M6D84_RS19485	COG3336	cytochrome c oxidase
M6D84_RS19520	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M6D84_RS19525	COG0772	Belongs to the SEDS family
M6D84_RS19535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M6D84_RS19540	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M6D84_RS19550	COG4896	Protein conserved in bacteria
M6D84_RS19565	COG1217	gtp-binding protein TYPA
M6D84_RS19575	COG0483	inositol monophosphate 1-phosphatase activity
M6D84_RS19595	COG1982	Orn Lys Arg decarboxylase major
M6D84_RS19645	COG0022	dehydrogenase e1 component
M6D84_RS19650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M6D84_RS19665	COG0561	phosphatase activity
M6D84_RS19675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M6D84_RS19680	COG0569	domain protein
M6D84_RS19700	COG0583	DNA-binding transcription factor activity
M6D84_RS19705	COG0517	IMP dehydrogenase activity
M6D84_RS19715	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M6D84_RS19725	COG4703	Protein of unknown function (DUF1797)
M6D84_RS19740	COG2200	EAL domain
M6D84_RS19745	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS19750	COG1408	metallophosphoesterase
M6D84_RS19795	COG2814	Major facilitator Superfamily
M6D84_RS19815	COG3209	COG3209 Rhs family protein
M6D84_RS19825	COG2205	protein histidine kinase activity
M6D84_RS19835	COG0436	Aminotransferase
M6D84_RS19840	COG1609	Transcriptional regulator
M6D84_RS19845	COG3833	ABC-type maltose transport systems, permease component
M6D84_RS19850	COG1175	transmembrane transport
M6D84_RS19855	COG2182	Extracellular solute-binding protein
M6D84_RS19865	COG0366	Alpha amylase catalytic
M6D84_RS19870	COG3842	ATPase activity
M6D84_RS19910	COG0183	Belongs to the thiolase family
M6D84_RS19945	COG1695	Transcriptional regulator
M6D84_RS19950	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS19970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M6D84_RS19975	COG0436	Aminotransferase
M6D84_RS20010	COG2084	Dehydrogenase
M6D84_RS20020	COG2199	diguanylate cyclase activity
M6D84_RS20025	COG0778	Nitroreductase
M6D84_RS20050	COG1263	PTS System
M6D84_RS20050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_RS20050	COG2190	(PTS) system
M6D84_RS20055	COG3711	transcriptional antiterminator
M6D84_RS20065	COG2188	Transcriptional regulator
M6D84_RS20075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M6D84_RS20100	COG1547	Domain of unknown function (DUF309)
M6D84_RS20105	COG0456	acetyltransferase
M6D84_RS20110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M6D84_RS20115	COG4086	secreted protein
M6D84_RS20120	COG0561	phosphatase activity
M6D84_RS20125	COG0697	spore germination
M6D84_RS20140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M6D84_RS20165	COG0733	neurotransmitter:sodium symporter activity
M6D84_RS20185	COG1686	Belongs to the peptidase S11 family
M6D84_RS20190	COG1725	Transcriptional regulator
M6D84_RS20195	COG1131	(ABC) transporter
M6D84_RS20215	COG1846	Transcriptional regulator
M6D84_RS20230	COG0598	Magnesium transport protein CorA
M6D84_RS20255	COG4974	Belongs to the 'phage' integrase family
M6D84_RS20265	COG0735	belongs to the Fur family
M6D84_RS20270	COG1300	Membrane
M6D84_RS20290	COG0667	Aldo Keto reductase
M6D84_RS20295	COG0656	L-ascorbic acid biosynthetic process
M6D84_RS20300	COG0456	acetyltransferase
M6D84_RS20300	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M6D84_RS20310	COG0737	Belongs to the 5'-nucleotidase family
M6D84_RS20310	COG1525	nuclease
M6D84_RS20310	COG4085	toxin activity
M6D84_RS20320	COG0596	Alpha beta hydrolase
M6D84_RS20325	COG2056	Na+-H+ antiporter family
M6D84_RS20330	COG1609	Transcriptional regulator
M6D84_RS20335	COG0456	acetyltransferase
M6D84_RS20340	COG1073	alpha beta
M6D84_RS20355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M6D84_RS20355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M6D84_RS20360	COG0307	riboflavin synthase, alpha
M6D84_RS20390	COG1073	alpha beta
M6D84_RS20390	COG2226	methyltransferase
M6D84_RS20405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M6D84_RS20415	COG1757	Na H antiporter
M6D84_RS20420	COG0737	Belongs to the 5'-nucleotidase family
M6D84_RS20430	COG1522	sequence-specific DNA binding
M6D84_RS20475	COG0300	oxidoreductase activity
M6D84_RS20480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_RS20485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M6D84_RS20490	COG1760	l-serine dehydratase
M6D84_RS20495	COG1760	l-serine dehydratase
M6D84_RS20525	COG1285	pathogenesis
M6D84_RS20535	COG2195	Cleaves the N-terminal amino acid of tripeptides
M6D84_RS20540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS20555	COG1376	ErfK ybiS ycfS ynhG family protein
M6D84_RS20560	COG4129	membrane
M6D84_RS20565	COG1126	abc transporter atp-binding protein
M6D84_RS20570	COG0765	amino acid transport
M6D84_RS20575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_RS20590	COG2816	NAD+ diphosphatase activity
M6D84_RS20595	COG2323	membrane
M6D84_RS20600	COG0772	Belongs to the SEDS family
M6D84_RS20605	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6D84_RS20610	COG0022	dehydrogenase e1 component
M6D84_RS20615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M6D84_RS20620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M6D84_RS20635	COG0280	phosphate acetyltransferase
M6D84_RS20640	COG3290	protein histidine kinase activity
M6D84_RS20640	COG3829	transcription factor binding
M6D84_RS20650	COG0584	glycerophosphoryl diester phosphodiesterase
M6D84_RS20655	COG3093	addiction module antidote protein HigA
M6D84_RS20670	COG0750	zinc metalloprotease
M6D84_RS20675	COG0497	DNA recombination
M6D84_RS20685	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M6D84_RS20695	COG0142	geranyltranstransferase activity
M6D84_RS20720	COG1302	Protein conserved in bacteria
M6D84_RS20725	COG0439	Biotin carboxylase
M6D84_RS20730	COG0511	ligase activity, forming carbon-carbon bonds
M6D84_RS20775	COG3854	ATPases associated with a variety of cellular activities
M6D84_RS20800	COG0006	proline dipeptidase activity
M6D84_RS20815	COG3872	metal-dependent enzyme
M6D84_RS20825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M6D84_RS20840	COG1695	Transcriptional regulator
M6D84_RS20860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_RS20870	COG1609	Transcriptional regulator
M6D84_RS20880	COG2076	Multidrug Resistance protein
M6D84_RS20885	COG2076	Multidrug Resistance protein
M6D84_RS20915	COG1131	(ABC) transporter
M6D84_RS20920	COG1725	Transcriptional regulator
M6D84_RS20950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M6D84_RS21015	COG1459	type II secretion system
M6D84_RS21020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M6D84_RS21075	COG0646	methionine synthase
M6D84_RS21075	COG1410	methionine synthase
M6D84_RS21080	COG0646	methionine synthase
M6D84_RS21080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M6D84_RS21085	COG0626	cystathionine gamma-synthase activity
M6D84_RS21090	COG0626	cystathionine gamma-synthase activity
M6D84_RS21110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_RS21120	COG1940	carbohydrate kinase activity
M6D84_RS21125	COG4483	Protein conserved in bacteria
M6D84_RS21130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M6D84_RS21135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M6D84_RS21140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M6D84_RS21145	COG0704	Plays a role in the regulation of phosphate uptake
M6D84_RS21155	COG0573	inorganic phosphate transmembrane transporter activity
M6D84_RS21160	COG0573	inorganic phosphate transmembrane transporter activity
M6D84_RS21165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M6D84_RS21170	COG0768	penicillin binding
M6D84_RS21180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M6D84_RS21190	COG5521	maltodextrose utilization protein MalA
M6D84_RS21205	COG0735	belongs to the Fur family
M6D84_RS21210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M6D84_RS21215	COG1121	(ABC) transporter
M6D84_RS21220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_RS21250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M6D84_RS21255	COG2384	SAM-dependent methyltransferase
M6D84_RS21265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M6D84_RS21270	COG0358	DNA primase activity
M6D84_RS21285	COG0517	IMP dehydrogenase activity
M6D84_RS21300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M6D84_RS21305	COG0295	cytidine deaminase activity
M6D84_RS21310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M6D84_RS21320	COG1480	7TM receptor with intracellular HD hydrolase
M6D84_RS21325	COG1702	phosphate starvation-inducible protein PhoH
M6D84_RS21345	COG1610	YqeY-like protein
M6D84_RS21350	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M6D84_RS21355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M6D84_RS21360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M6D84_RS21390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M6D84_RS21395	COG1733	regulation of RNA biosynthetic process
M6D84_RS21420	COG1466	dna polymerase III delta subunit
M6D84_RS21430	COG2333	competence protein COMEC
M6D84_RS21430	COG0658	competence protein
M6D84_RS21435	COG2131	deaminase
M6D84_RS21440	COG1555	photosystem II stabilization
M6D84_RS21440	COG1596	polysaccharide export
M6D84_RS21445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M6D84_RS21450	COG2226	methyltransferase
M6D84_RS21455	COG0799	negative regulation of ribosome biogenesis
M6D84_RS21460	COG1713	HD superfamily hydrolase involved in NAD metabolism
M6D84_RS21470	COG1534	Rna-binding protein
M6D84_RS21480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M6D84_RS21485	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M6D84_RS21520	COG0778	Nitroreductase
M6D84_RS21525	COG2357	RelA SpoT domain protein
M6D84_RS21535	COG1785	Belongs to the alkaline phosphatase family
M6D84_RS21545	COG2267	carboxylic ester hydrolase activity
M6D84_RS21580	COG1404	Belongs to the peptidase S8 family
M6D84_RS21585	COG3186	Phenylalanine-4-hydroxylase
M6D84_RS21595	COG2514	catechol 2,3-dioxygenase activity
M6D84_RS21600	COG2259	Doxx family
M6D84_RS21640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_RS21650	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_RS21650	COG1454	alcohol dehydrogenase
M6D84_RS21655	COG0626	cystathionine gamma-synthase activity
M6D84_RS21660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M6D84_RS21685	COG0768	penicillin binding
M6D84_RS21705	COG0826	peptidase U32
M6D84_RS21710	COG0826	peptidase U32
M6D84_RS21715	COG4122	O-methyltransferase activity
M6D84_RS21720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M6D84_RS21750	COG0628	permease
M6D84_RS21770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M6D84_RS21785	COG1104	cysteine desulfurase activity
M6D84_RS21790	COG1959	2 iron, 2 sulfur cluster binding
M6D84_RS21795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M6D84_RS21805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M6D84_RS21830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M6D84_RS21840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M6D84_RS21840	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M6D84_RS21845	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M6D84_RS21850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M6D84_RS21850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M6D84_RS21860	COG2244	polysaccharide biosynthetic process
M6D84_RS21865	COG2323	membrane
M6D84_RS21875	COG1862	Preprotein translocase
M6D84_RS21905	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M6D84_RS21935	COG0157	Belongs to the NadC ModD family
M6D84_RS21940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M6D84_RS21945	COG1104	cysteine desulfurase activity
M6D84_RS21950	COG1827	regulation of RNA biosynthetic process
M6D84_RS21955	COG2258	MOSC domain
M6D84_RS21960	COG0077	Prephenate dehydratase
M6D84_RS21965	COG0577	efflux transmembrane transporter activity
M6D84_RS21970	COG0577	efflux transmembrane transporter activity
M6D84_RS21975	COG1136	(ABC) transporter
M6D84_RS21980	COG5002	protein histidine kinase activity
M6D84_RS21985	COG0745	RESPONSE REGULATOR receiver
M6D84_RS21995	COG3290	protein histidine kinase activity
M6D84_RS22005	COG2868	ribosomal protein
M6D84_RS22015	COG1530	ribonuclease E activity
M6D84_RS22020	COG1994	Peptidase M50
M6D84_RS22025	COG0739	heme binding
M6D84_RS22030	COG2894	cell division
M6D84_RS22050	COG1077	Cell shape determining protein MreB Mrl
M6D84_RS22070	COG0285	dihydrofolate synthase activity
M6D84_RS22085	COG1388	LysM domain
M6D84_RS22095	COG0113	porphobilinogen synthase activity
M6D84_RS22100	COG1587	Uroporphyrinogen-III synthase
M6D84_RS22110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M6D84_RS22120	COG1846	Transcriptional regulator
M6D84_RS22125	COG1764	response to oxidative stress
M6D84_RS22140	COG1067	ATP-dependent peptidase activity
M6D84_RS22140	COG0470	DNA polymerase III
M6D84_RS22185	COG0622	Phosphoesterase
M6D84_RS22200	COG5401	PFAM Sporulation and spore germination
M6D84_RS22225	COG1309	transcriptional regulator
M6D84_RS22235	COG2197	response regulator
M6D84_RS22240	COG2233	PERMEase
M6D84_RS22245	COG0402	S-adenosylhomocysteine deaminase activity
M6D84_RS22250	COG1983	PspC domain protein
M6D84_RS22255	COG1396	sequence-specific DNA binding
M6D84_RS22260	COG0697	spore germination
M6D84_RS22270	COG1959	2 iron, 2 sulfur cluster binding
M6D84_RS22275	COG1668	transmembrane transport
M6D84_RS22280	COG4152	abc transporter atp-binding protein
M6D84_RS22285	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M6D84_RS22290	COG1360	Flagellar Motor Protein
M6D84_RS22295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M6D84_RS22300	COG1876	peptidase activity
M6D84_RS22305	COG0824	Thioesterase
M6D84_RS22310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M6D84_RS22315	COG1053	succinate dehydrogenase
M6D84_RS22320	COG2009	succinate dehydrogenase
M6D84_RS22325	COG1719	4-vinyl reductase, 4VR
M6D84_RS22335	COG3118	belongs to the thioredoxin family
M6D84_RS22340	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M6D84_RS22345	COG2086	electron transfer activity
M6D84_RS22350	COG1024	Enoyl-CoA hydratase
M6D84_RS22355	COG1309	transcriptional regulator
M6D84_RS22360	COG0318	PFAM AMP-dependent synthetase and ligase
M6D84_RS22385	COG2318	DinB family
M6D84_RS22410	COG1131	(ABC) transporter
M6D84_RS22415	COG2205	protein histidine kinase activity
M6D84_RS22420	COG0745	RESPONSE REGULATOR receiver
M6D84_RS22430	COG4895	conserved protein (DUF2196)
M6D84_RS22435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M6D84_RS22445	COG4509	Sortase family
M6D84_RS22450	COG1120	ATPase activity
M6D84_RS22465	COG5386	Cell surface protein
M6D84_RS22475	COG5386	Cell surface protein
M6D84_RS22480	COG1114	Component of the transport system for branched-chain amino acids
M6D84_RS22485	COG1187	pseudouridine synthase activity
M6D84_RS22495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M6D84_RS22495	COG1796	DNA polymerase
M6D84_RS22500	COG1286	toxin biosynthetic process
M6D84_RS22545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M6D84_RS22555	COG1418	mRNA catabolic process
M6D84_RS22565	COG2814	Major facilitator Superfamily
M6D84_RS22570	COG1566	PFAM secretion protein HlyD family protein
M6D84_RS22575	COG1309	transcriptional regulator
M6D84_RS22580	COG1363	Peptidase, m42
M6D84_RS22605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M6D84_RS22620	COG1484	DNA-dependent DNA replication
M6D84_RS22625	COG3611	Membrane attachment protein
M6D84_RS22635	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M6D84_RS22640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M6D84_RS22650	COG1971	Probably functions as a manganese efflux pump
M6D84_RS22660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6D84_RS22660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6D84_RS22665	COG5002	protein histidine kinase activity
M6D84_RS22670	COG0745	RESPONSE REGULATOR receiver
M6D84_RS22690	COG0538	isocitrate dehydrogenase activity
M6D84_RS22695	COG0372	Belongs to the citrate synthase family
M6D84_RS22705	COG0628	permease
M6D84_RS22710	COG3030	protein affecting phage T7 exclusion by the F plasmid
M6D84_RS22735	COG1725	Transcriptional regulator
M6D84_RS22740	COG0281	malic enzyme
M6D84_RS22745	COG0587	DNA-directed DNA polymerase activity
M6D84_RS22760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M6D84_RS22775	COG4109	DRTGG domain
M6D84_RS22790	COG0006	proline dipeptidase activity
M6D84_RS22830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS22835	COG0662	Cupin 2, conserved barrel domain protein
M6D84_RS22850	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_RS22855	COG0589	response to stress
M6D84_RS22895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_RS22920	COG0827	DNA restriction-modification system
M6D84_RS22925	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M6D84_RS22930	COG3874	Sporulation protein YtfJ
M6D84_RS22945	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M6D84_RS22955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M6D84_RS22970	COG1104	cysteine desulfurase activity
M6D84_RS22980	COG0583	DNA-binding transcription factor activity
M6D84_RS22985	COG0697	spore germination
M6D84_RS22990	COG1309	transcriptional regulator
M6D84_RS22995	COG1956	GAF domain-containing protein
M6D84_RS23000	COG0626	cystathionine gamma-synthase activity
M6D84_RS23050	COG0110	maltose O-acetyltransferase activity
M6D84_RS23055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M6D84_RS23060	COG0454	-acetyltransferase
M6D84_RS23065	COG0517	IMP dehydrogenase activity
M6D84_RS23070	COG0123	including yeast histone deacetylase and acetoin utilization protein
M6D84_RS23085	COG0745	RESPONSE REGULATOR receiver
M6D84_RS23095	COG0666	response to abiotic stimulus
M6D84_RS23130	COG1609	Transcriptional regulator
M6D84_RS23135	COG1605	Chorismate mutase
M6D84_RS23135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M6D84_RS23140	COG4851	CamS sex pheromone cAM373 precursor
M6D84_RS23155	COG2309	aminopeptidase activity
M6D84_RS23170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS23185	COG1674	ftsk spoiiie
M6D84_RS23190	COG1388	LysM domain
M6D84_RS23190	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_RS23200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M6D84_RS23210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_RS23215	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M6D84_RS23220	COG1363	Peptidase, m42
M6D84_RS23230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_RS23245	COG0510	thiamine kinase activity
M6D84_RS23250	COG1523	belongs to the glycosyl hydrolase 13 family
M6D84_RS23260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M6D84_RS23265	COG1349	DNA-binding transcription factor activity
M6D84_RS23270	COG1187	pseudouridine synthase activity
M6D84_RS23275	COG2244	polysaccharide biosynthetic process
M6D84_RS23280	COG2081	HI0933 family
M6D84_RS23285	COG2814	Major facilitator Superfamily
M6D84_RS23295	COG3832	glyoxalase III activity
M6D84_RS23315	COG1329	Transcriptional regulator
M6D84_RS23340	COG0314	molybdopterin synthase activity
M6D84_RS23345	COG1763	Mo-molybdopterin cofactor biosynthetic process
M6D84_RS23350	COG0303	'Molybdopterin
M6D84_RS23360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M6D84_RS23365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M6D84_RS23385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_RS23395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M6D84_RS23435	COG2814	Major facilitator Superfamily
M6D84_RS23440	COG0475	glutathione-regulated potassium exporter activity
M6D84_RS23445	COG0490	domain, Protein
M6D84_RS23450	COG0582	viral genome integration into host DNA
M6D84_RS23460	COG1136	(ABC) transporter
M6D84_RS23480	COG1242	4 iron, 4 sulfur cluster binding
M6D84_RS23485	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M6D84_RS23490	COG1794	racemase activity, acting on amino acids and derivatives
M6D84_RS23505	COG2267	carboxylic ester hydrolase activity
M6D84_RS23510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M6D84_RS23515	COG0671	phosphoesterase, PA-phosphatase related
M6D84_RS23520	COG0438	transferase activity, transferring glycosyl groups
M6D84_RS23590	COG5002	protein histidine kinase activity
M6D84_RS23595	COG3852	Histidine kinase
M6D84_RS23600	COG0753	catalase activity
M6D84_RS23610	COG2267	carboxylic ester hydrolase activity
M6D84_RS23615	COG1368	sulfuric ester hydrolase activity
M6D84_RS23640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M6D84_RS23645	COG1116	anion transmembrane transporter activity
M6D84_RS23650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D84_RS23675	COG0494	nUDIX hydrolase
M6D84_RS23705	COG1854	S-ribosylhomocysteine lyase activity
M6D84_RS23715	COG0288	reversible hydration of carbon dioxide
M6D84_RS23720	COG1271	oxidase subunit
M6D84_RS23725	COG1294	oxidase, subunit
M6D84_RS23740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_RS23765	COG1842	Phage shock protein A
M6D84_RS23795	COG5002	protein histidine kinase activity
M6D84_RS23800	COG0745	RESPONSE REGULATOR receiver
M6D84_RS23825	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M6D84_RS23830	COG1597	lipid kinase activity
M6D84_RS23875	COG0586	Pfam SNARE associated Golgi protein
M6D84_RS23885	COG0577	efflux transmembrane transporter activity
M6D84_RS23890	COG1136	(ABC) transporter
M6D84_RS23895	COG2207	Transcriptional regulator
M6D84_RS23895	COG3708	Transcriptional regulator
M6D84_RS23915	COG5658	integral membrane protein
M6D84_RS23920	COG0640	Transcriptional regulator
M6D84_RS23925	COG0745	RESPONSE REGULATOR receiver
M6D84_RS23930	COG2205	protein histidine kinase activity
M6D84_RS23935	COG0577	efflux transmembrane transporter activity
M6D84_RS23940	COG0577	efflux transmembrane transporter activity
M6D84_RS23945	COG1136	(ABC) transporter
M6D84_RS23950	COG0577	efflux transmembrane transporter activity
M6D84_RS23965	COG2188	Transcriptional regulator
M6D84_RS23985	COG3964	amidohydrolase
M6D84_RS24005	COG4948	Mandelate Racemase Muconate Lactonizing
M6D84_RS24015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M6D84_RS24020	COG0596	Alpha beta hydrolase
M6D84_RS24030	COG1169	isochorismate synthase
M6D84_RS24035	COG1575	Belongs to the MenA family. Type 1 subfamily
M6D84_RS24040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M6D84_RS24065	COG0058	SHG alpha-glucan phosphorylase activity
M6D84_RS24075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M6D84_RS24190	COG0544	peptidyl-prolyl cis-trans isomerase activity
M6D84_RS24225	COG1285	pathogenesis
M6D84_RS24230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M6D84_RS24245	COG2155	Conserved Protein
M6D84_RS24250	COG1098	S1 RNA binding domain
M6D84_RS24255	COG0436	Aminotransferase
M6D84_RS24260	COG1522	sequence-specific DNA binding
M6D84_RS24265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M6D84_RS24270	COG2267	carboxylic ester hydrolase activity
M6D84_RS24280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M6D84_RS24300	COG5018	Exonuclease
M6D84_RS24305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M6D84_RS24325	COG2050	protein possibly involved in aromatic compounds catabolism
M6D84_RS24335	COG1268	BioY protein
M6D84_RS24340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M6D84_RS24345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M6D84_RS24365	COG2076	Multidrug Resistance protein
M6D84_RS24370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M6D84_RS24380	COG3584	3D domain protein
M6D84_RS24395	COG1252	NADH dehydrogenase
M6D84_RS24410	COG3708	Transcriptional regulator
M6D84_RS24425	COG1683	Conserved Protein
M6D84_RS24445	COG0316	Belongs to the HesB IscA family
M6D84_RS24460	COG1252	NADH dehydrogenase
M6D84_RS24470	COG2274	protein secretion by the type I secretion system
M6D84_RS24475	COG0390	transport system, permease component
M6D84_RS24480	COG2824	Alkylphosphonate utilization operon protein PhnA
M6D84_RS24505	COG4837	Protein of unknown function (DUF1462)
M6D84_RS24510	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M6D84_RS24520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M6D84_RS24525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M6D84_RS24545	COG1358	cellular component organization or biogenesis
M6D84_RS24560	COG0577	efflux transmembrane transporter activity
M6D84_RS24560	COG1136	(ABC) transporter
M6D84_RS24565	COG2249	NAD(P)H dehydrogenase (quinone) activity
M6D84_RS24575	COG0647	UMP catabolic process
M6D84_RS24585	COG2445	Protein of unknown function DUF86
M6D84_RS24590	COG1494	fructose-1,6-bisphosphatase
M6D84_RS24610	COG4470	Protein conserved in bacteria
M6D84_RS24620	COG0789	Transcriptional regulator
M6D84_RS24625	COG4377	Putative membrane peptidase family (DUF2324)
M6D84_RS24650	COG0739	heme binding
M6D84_RS24660	COG3377	Domain of unknown function (DUF1805)
M6D84_RS24665	COG0737	Belongs to the 5'-nucleotidase family
M6D84_RS24670	COG0719	Fe-S assembly protein
M6D84_RS24675	COG0822	iron-sulfur transferase activity
M6D84_RS24680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M6D84_RS24685	COG0719	Fe-S assembly protein
M6D84_RS24690	COG0396	ATPase activity
M6D84_RS24695	COG1464	Belongs to the NlpA lipoprotein family
M6D84_RS24700	COG1464	Belongs to the NlpA lipoprotein family
M6D84_RS24705	COG2011	ABC-type metal ion transport system permease component
M6D84_RS24720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_RS24725	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M6D84_RS24740	COG1393	Belongs to the ArsC family
M6D84_RS24780	COG1309	transcriptional regulator
M6D84_RS24785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_RS24790	COG1960	acyl-CoA dehydrogenase activity
M6D84_RS24795	COG0183	Belongs to the thiolase family
M6D84_RS24800	COG1024	Enoyl-CoA hydratase
M6D84_RS24800	COG1250	3-hydroxyacyl-CoA dehydrogenase
M6D84_RS24810	COG1686	Belongs to the peptidase S11 family
M6D84_RS24825	COG0011	TIGRFAM Protein of
M6D84_RS24830	COG0840	transmembrane signaling receptor activity
M6D84_RS24845	COG2814	Major facilitator Superfamily
M6D84_RS24850	COG0531	amino acid
M6D84_RS24875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_RS24910	COG0586	Pfam SNARE associated Golgi protein
M6D84_RS24920	COG1376	ErfK ybiS ycfS ynhG family protein
M6D84_RS24925	COG0745	RESPONSE REGULATOR receiver
M6D84_RS24930	COG5002	protein histidine kinase activity
M6D84_RS24960	COG0840	transmembrane signaling receptor activity
M6D84_RS24965	COG2151	metal-sulfur cluster biosynthetic enzyme
M6D84_RS24970	COG3227	Zinc metalloprotease (Elastase)
M6D84_RS24975	COG1741	Belongs to the pirin family
M6D84_RS24990	COG0475	glutathione-regulated potassium exporter activity
M6D84_RS24995	COG0490	domain, Protein
M6D84_RS25000	COG1115	amino acid carrier protein
M6D84_RS25005	COG0783	Belongs to the Dps family
M6D84_RS25020	COG1611	Belongs to the LOG family
M6D84_RS25030	COG1528	Iron-storage protein
M6D84_RS25040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_RS25045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_RS25050	COG1115	amino acid carrier protein
M6D84_RS25055	COG1115	amino acid carrier protein
M6D84_RS25060	COG2910	NAD(P)H-binding
M6D84_RS25075	COG0656	L-ascorbic acid biosynthetic process
M6D84_RS25080	COG2814	Major facilitator Superfamily
M6D84_RS25085	COG1733	regulation of RNA biosynthetic process
M6D84_RS25095	COG1252	NADH dehydrogenase
M6D84_RS25150	COG0488	(ABC) transporter
M6D84_RS25155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_RS25200	COG0745	RESPONSE REGULATOR receiver
M6D84_RS25215	COG0557	exoribonuclease II activity
M6D84_RS25220	COG1647	Serine aminopeptidase, S33
M6D84_RS25225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M6D84_RS25230	COG1346	cytolysis
M6D84_RS25265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M6D84_RS25280	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M6D84_RS25285	COG1668	transmembrane transport
M6D84_RS25290	COG4152	abc transporter atp-binding protein
M6D84_RS25295	COG4585	Histidine kinase
M6D84_RS25325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M6D84_RS25340	COG2323	membrane
M6D84_RS25350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6D84_RS25360	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M6D84_RS25370	COG1051	belongs to the nudix hydrolase family
M6D84_RS25380	COG0492	ferredoxin-NADP+ reductase activity
M6D84_RS25385	COG0457	Tetratricopeptide repeat
M6D84_RS25390	COG0110	maltose O-acetyltransferase activity
M6D84_RS25410	COG1950	PFAM Membrane protein of
M6D84_RS25420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M6D84_RS25425	COG0556	nucleotide-excision repair
M6D84_RS25440	COG0789	Transcriptional regulator
M6D84_RS25470	COG0583	DNA-binding transcription factor activity
M6D84_RS25480	COG0655	NAD(P)H dehydrogenase (quinone) activity
M6D84_RS25485	COG0488	(ABC) transporter
M6D84_RS25495	COG1132	(ABC) transporter
M6D84_RS25500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M6D84_RS25505	COG3409	Peptidoglycan-binding domain 1 protein
M6D84_RS25505	COG0793	Belongs to the peptidase S41A family
M6D84_RS25510	COG2177	Part of the ABC transporter FtsEX involved in
M6D84_RS25515	COG2884	Cell division ATP-binding protein ftsE
M6D84_RS25540	COG1131	(ABC) transporter
M6D84_RS25570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M6D84_RS25575	COG1278	Cold shock
M6D84_RS25580	COG1040	competence protein
M6D84_RS25585	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M6D84_RS25590	COG0791	NLP P60 protein
M6D84_RS25590	COG1388	LysM domain
M6D84_RS25595	COG1733	regulation of RNA biosynthetic process
M6D84_RS25600	COG1307	EDD domain protein, DegV family
M6D84_RS25605	COG1739	Uncharacterized protein family UPF0029
M6D84_RS25610	COG1316	TRANSCRIPTIONal
M6D84_RS25615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M6D84_RS25620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M6D84_RS25625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M6D84_RS25635	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M6D84_RS25635	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M6D84_RS25655	COG1486	melibiose metabolic process
M6D84_RS25660	COG1447	Phosphotransferase system cellobiose-specific component IIA
M6D84_RS25665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M6D84_RS25685	COG1447	Phosphotransferase system cellobiose-specific component IIA
M6D84_RS25695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M6D84_RS25700	COG1301	dicarboxylic acid transport
M6D84_RS25715	COG1511	domain protein
M6D84_RS25720	COG0583	DNA-binding transcription factor activity
M6D84_RS25725	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M6D84_RS25735	COG1271	oxidase subunit
M6D84_RS25740	COG1294	oxidase, subunit
M6D84_RS25745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M6D84_RS25770	COG1620	l-lactate permease
M6D84_RS25780	COG2389	metal-binding protein
M6D84_RS25790	COG1368	sulfuric ester hydrolase activity
M6D84_RS25800	COG0791	NLP P60 protein
M6D84_RS25800	COG1388	LysM domain
M6D84_RS25805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_RS25815	COG1215	transferase activity, transferring glycosyl groups
M6D84_RS25820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M6D84_RS25825	COG3584	3D domain protein
M6D84_RS25825	COG1388	LysM domain
M6D84_RS25850	COG4715	Zinc finger, swim domain protein
M6D84_RS25855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M6D84_RS25895	COG0577	efflux transmembrane transporter activity
M6D84_RS25900	COG1136	(ABC) transporter
M6D84_RS25925	COG5002	protein histidine kinase activity
M6D84_RS25930	COG0745	RESPONSE REGULATOR receiver
M6D84_RS25935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M6D84_RS25945	COG1316	TRANSCRIPTIONal
M6D84_RS25955	COG0438	transferase activity, transferring glycosyl groups
M6D84_RS25960	COG0463	Glycosyl transferase, family 2
M6D84_RS25960	COG1216	Glycosyl transferase, family 2
M6D84_RS25995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M6D84_RS26000	COG4464	protein tyrosine phosphatase activity
M6D84_RS26005	COG0489	protein tyrosine kinase activity
M6D84_RS26010	COG3944	biosynthesis protein
M6D84_RS26015	COG0489	protein tyrosine kinase activity
M6D84_RS26030	COG1609	Transcriptional regulator
M6D84_RS26040	COG0739	heme binding
M6D84_RS26055	COG3279	Response regulator of the LytR AlgR family
M6D84_RS26060	COG2385	sporulation resulting in formation of a cellular spore
M6D84_RS26075	COG4836	Membrane
M6D84_RS26085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M6D84_RS26090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M6D84_RS26100	COG0839	Belongs to the complex I subunit 6 family
M6D84_RS26120	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M6D84_RS26135	COG5001	Diguanylate cyclase
M6D84_RS26135	COG3300	MHYT domain
M6D84_RS26185	COG0356	it plays a direct role in the translocation of protons across the membrane
M6D84_RS26220	COG0698	ribose 5-phosphate isomerase
M6D84_RS26235	COG2259	Doxx family
M6D84_RS26240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M6D84_RS26255	COG0009	L-threonylcarbamoyladenylate synthase
M6D84_RS26290	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M6D84_RS26295	COG1494	fructose-1,6-bisphosphatase
M6D84_RS26315	COG4821	SIS domain
M6D84_RS26325	COG3343	RNA polymerase activity
M6D84_RS26335	COG1960	acyl-CoA dehydrogenase activity
M6D84_RS26340	COG1960	acyl-CoA dehydrogenase activity
M6D84_RS26345	COG1250	3-hydroxyacyl-CoA dehydrogenase
M6D84_RS26350	COG0183	Belongs to the thiolase family
M6D84_RS26355	COG2181	nitrate reductase activity
M6D84_RS26355	COG0247	lactate metabolic process
M6D84_RS26360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M6D84_RS26370	COG5001	Diguanylate cyclase
M6D84_RS26370	COG3300	MHYT domain
M6D84_RS26385	COG3227	Zinc metalloprotease (Elastase)
M6D84_RS26390	COG2197	response regulator
M6D84_RS26395	COG4585	Histidine kinase
M6D84_RS26400	COG0842	Transport permease protein
M6D84_RS26405	COG1131	(ABC) transporter
M6D84_RS26410	COG0024	Methionine aminopeptidase
M6D84_RS26420	COG2234	aminopeptidase activity
M6D84_RS26450	COG4506	Protein conserved in bacteria
M6D84_RS26455	COG1619	proteins homologs of microcin C7 resistance protein MccF
M6D84_RS26480	COG2814	Major facilitator Superfamily
M6D84_RS26485	COG0789	Transcriptional regulator
M6D84_RS26490	COG0584	glycerophosphoryl diester phosphodiesterase
M6D84_RS26495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D84_RS26505	COG1994	Peptidase M50
M6D84_RS26515	COG1078	dGTPase activity
M6D84_RS26520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_RS26525	COG1120	ATPase activity
M6D84_RS26530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_RS26535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_RS26555	COG0280	phosphate acetyltransferase
M6D84_RS26570	COG3773	Cell wall hydrolase
M6D84_RS26580	COG2363	Small membrane protein
M6D84_RS26590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M6D84_RS26595	COG2233	PERMEase
M6D84_RS26600	COG0561	phosphatase activity
M6D84_RS26605	COG2814	Major facilitator Superfamily
M6D84_RS26615	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M6D84_RS26620	COG1131	(ABC) transporter
M6D84_RS26625	COG2755	lipolytic protein G-D-S-L family
M6D84_RS26630	COG1609	Transcriptional regulator
M6D84_RS26640	COG0460	homoserine dehydrogenase
M6D84_RS26650	COG2873	o-acetylhomoserine
M6D84_RS26660	COG1011	Hydrolase
M6D84_RS26665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M6D84_RS26675	COG2197	response regulator
M6D84_RS26680	COG2203	Gaf domain
M6D84_RS26680	COG4585	Histidine kinase
M6D84_RS26685	COG0351	phosphomethylpyrimidine kinase
M6D84_RS26690	COG3706	GGDEF domain
M6D84_RS26695	COG2879	small protein
M6D84_RS26700	COG1966	Carbon starvation protein
M6D84_RS26705	COG3279	Response regulator of the LytR AlgR family
M6D84_RS26710	COG0477	Major facilitator Superfamily
M6D84_RS26715	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M6D84_RS26720	COG0438	transferase activity, transferring glycosyl groups
M6D84_RS26735	COG0840	transmembrane signaling receptor activity
M6D84_RS26745	COG1607	acyl-coa hydrolase
M6D84_RS26750	COG1216	Glycosyl transferase, family 2
M6D84_RS26760	COG1216	Glycosyl transferase, family 2
M6D84_RS26770	COG4485	Bacterial membrane protein, YfhO
M6D84_RS26775	COG0463	Glycosyl transferase, family 2
M6D84_RS26780	COG0488	(ABC) transporter
M6D84_RS26785	COG1309	transcriptional regulator
M6D84_RS26790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M6D84_RS26795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M6D84_RS26805	COG0628	permease
M6D84_RS26825	COG3275	phosphorelay sensor kinase activity
M6D84_RS26830	COG2814	Major facilitator Superfamily
M6D84_RS26835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M6D84_RS26840	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M6D84_RS26860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M6D84_RS26865	COG1272	protein, Hemolysin III
M6D84_RS26885	COG1164	Oligoendopeptidase f
M6D84_RS26895	COG5002	protein histidine kinase activity
M6D84_RS26910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M6D84_RS26915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M6D84_RS26920	COG4853	Protein conserved in bacteria
M6D84_RS26930	COG5002	protein histidine kinase activity
M6D84_RS26935	COG0745	RESPONSE REGULATOR receiver
M6D84_RS26965	COG0305	Participates in initiation and elongation during chromosome replication
M6D84_RS26975	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M6D84_RS27000	COG0012	GTP binding
M6D84_RS27005	COG4481	Protein conserved in bacteria
M6D84_RS27010	COG0668	transmembrane transport
M6D84_RS27020	COG1475	DNA binding
M6D84_RS27025	COG1192	Involved in chromosome partitioning
M6D84_RS27050	COG1847	R3H domain protein
M6D84_RS27065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M6D84_RS27275	COG2323	membrane
M6D84_RS27280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M6D84_RS27295	COG3655	Transcriptional regulator
M6D84_RS27370	COG2207	Transcriptional regulator
M6D84_RS27370	COG3708	Transcriptional regulator
M6D84_RS27420	COG0789	Transcriptional regulator
M6D84_RS27490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M6D84_RS27505	COG4166	transmembrane transport
M6D84_RS27565	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M6D84_RS27610	COG4974	Belongs to the 'phage' integrase family
M6D84_RS27630	COG2002	toxin-antitoxin pair type II binding
M6D84_RS27700	COG2311	Membrane
M6D84_RS27860	COG0798	PFAM Bile acid sodium symporter
M6D84_RS27865	COG0640	Transcriptional regulator
M6D84_RS27880	COG2824	Alkylphosphonate utilization operon protein PhnA
M6D84_RS27895	COG0659	secondary active sulfate transmembrane transporter activity
M6D84_RS27910	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M6D84_RS27915	COG0659	secondary active sulfate transmembrane transporter activity
M6D84_RS27920	COG0589	response to stress
M6D84_RS27925	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M6D84_RS27935	COG2072	flavoprotein involved in K transport
M6D84_RS27950	COG0640	Transcriptional regulator
M6D84_RS28265	COG3344	reverse transcriptase
M6D84_RS28285	COG0583	DNA-binding transcription factor activity
M6D84_RS28290	COG2814	Major facilitator Superfamily
M6D84_RS28350	COG0546	phosphoglycolate phosphatase activity
M6D84_RS28365	COG0167	dihydroorotate dehydrogenase activity
M6D84_RS28370	COG3238	Protein conserved in bacteria
M6D84_RS28375	COG1611	Belongs to the LOG family
M6D84_RS28380	COG1475	DNA binding
M6D84_RS28385	COG2368	4-hydroxyphenylacetate
M6D84_RS28390	COG0494	nUDIX hydrolase
M6D84_RS28405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M6D84_RS28475	COG1073	alpha beta
M6D84_RS28485	COG1388	LysM domain
M6D84_RS28485	COG3103	Sh3 type 3 domain protein
M6D84_RS28485	COG0791	NLP P60 protein
M6D84_RS28525	COG3397	chitin binding
M6D84_RS28555	COG4974	Belongs to the 'phage' integrase family
M6D84_RS28560	COG1396	sequence-specific DNA binding
M6D84_RS28615	COG3344	reverse transcriptase
M6D84_RS28735	COG0457	Tetratricopeptide repeat
M6D84_RS28750	COG4974	Belongs to the 'phage' integrase family
M6D84_RS28760	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_RS28770	COG5002	protein histidine kinase activity
M6D84_RS28775	COG0745	RESPONSE REGULATOR receiver
M6D84_RS28780	COG2132	Multicopper oxidase
M6D84_RS28785	COG2304	oxidoreductase activity
M6D84_RS28790	COG1126	abc transporter atp-binding protein
M6D84_RS28795	COG0765	amino acid transport
M6D84_RS28800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_RS28810	COG3118	belongs to the thioredoxin family
M6D84_RS28850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_RS28870	COG3443	Belongs to the bacterial solute-binding protein 9 family
M6D84_RS28870	COG0803	Belongs to the bacterial solute-binding protein 9 family
M6D84_RS28875	COG1937	Protein conserved in bacteria
M6D84_RS28880	COG2217	Heavy metal translocating P-type atpase
M6D84_RS28920	COG1846	Transcriptional regulator
M6D84_RS28935	COG0640	Transcriptional regulator
M6D84_RS28940	COG0306	phosphate transporter
M6D84_RS28945	COG3620	sequence-specific DNA binding
M6D84_RS28955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M6D84_RS28975	COG0640	Transcriptional regulator
M6D84_RS28980	COG0798	PFAM Bile acid sodium symporter
M6D84_RS29035	COG0745	RESPONSE REGULATOR receiver
M6D84_RS29040	COG4990	cell redox homeostasis
M6D84_RS29045	COG1335	isochorismatase
M6D84_RS29075	COG2918	glutathione biosynthetic process
M6D84_RS29075	COG1181	Belongs to the D-alanine--D-alanine ligase family
M6D84_RS29085	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M6D84_RS29095	COG1733	regulation of RNA biosynthetic process
M6D84_RS29110	COG0697	spore germination