locus-tag	class	description
I6I41_RS00020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I41_RS00025	COG1121	(ABC) transporter
I6I41_RS00030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I41_RS00035	COG0735	belongs to the Fur family
I6I41_RS00050	COG5521	maltodextrose utilization protein MalA
I6I41_RS00060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I41_RS00065	COG0477	Major facilitator Superfamily
I6I41_RS00070	COG0768	penicillin binding
I6I41_RS00075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I41_RS00080	COG0573	inorganic phosphate transmembrane transporter activity
I6I41_RS00085	COG0573	inorganic phosphate transmembrane transporter activity
I6I41_RS00095	COG0704	Plays a role in the regulation of phosphate uptake
I6I41_RS00100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I41_RS00105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I41_RS00110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I41_RS00115	COG4483	Protein conserved in bacteria
I6I41_RS00120	COG1940	carbohydrate kinase activity
I6I41_RS00130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS00150	COG0626	cystathionine gamma-synthase activity
I6I41_RS00155	COG0626	cystathionine gamma-synthase activity
I6I41_RS00160	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I41_RS00160	COG0646	methionine synthase
I6I41_RS00165	COG1410	methionine synthase
I6I41_RS00165	COG0646	methionine synthase
I6I41_RS00220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I41_RS00225	COG1459	type II secretion system
I6I41_RS00290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I41_RS00320	COG1725	Transcriptional regulator
I6I41_RS00325	COG1131	(ABC) transporter
I6I41_RS00355	COG2076	Multidrug Resistance protein
I6I41_RS00360	COG2076	Multidrug Resistance protein
I6I41_RS00370	COG1609	Transcriptional regulator
I6I41_RS00380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I41_RS00400	COG1695	Transcriptional regulator
I6I41_RS00415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I41_RS00425	COG3872	metal-dependent enzyme
I6I41_RS00440	COG0006	proline dipeptidase activity
I6I41_RS00465	COG3854	ATPases associated with a variety of cellular activities
I6I41_RS00510	COG0511	ligase activity, forming carbon-carbon bonds
I6I41_RS00515	COG0439	Biotin carboxylase
I6I41_RS00520	COG1302	Protein conserved in bacteria
I6I41_RS00545	COG0142	geranyltranstransferase activity
I6I41_RS00555	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6I41_RS00565	COG0497	DNA recombination
I6I41_RS00570	COG0750	zinc metalloprotease
I6I41_RS00580	COG4974	Belongs to the 'phage' integrase family
I6I41_RS00675	COG3093	addiction module antidote protein HigA
I6I41_RS00680	COG0584	glycerophosphoryl diester phosphodiesterase
I6I41_RS00690	COG3829	transcription factor binding
I6I41_RS00690	COG3290	protein histidine kinase activity
I6I41_RS00695	COG0280	phosphate acetyltransferase
I6I41_RS00710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I41_RS00715	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I41_RS00720	COG0022	dehydrogenase e1 component
I6I41_RS00725	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I41_RS00730	COG0772	Belongs to the SEDS family
I6I41_RS00735	COG2323	membrane
I6I41_RS00740	COG2816	NAD+ diphosphatase activity
I6I41_RS00755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I41_RS00760	COG0765	amino acid transport
I6I41_RS00765	COG1126	abc transporter atp-binding protein
I6I41_RS00770	COG4129	membrane
I6I41_RS00775	COG1376	ErfK ybiS ycfS ynhG family protein
I6I41_RS00790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS00795	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I41_RS00805	COG1285	pathogenesis
I6I41_RS00830	COG1760	l-serine dehydratase
I6I41_RS00835	COG1760	l-serine dehydratase
I6I41_RS00840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I41_RS00845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS00850	COG0300	oxidoreductase activity
I6I41_RS00895	COG1522	sequence-specific DNA binding
I6I41_RS00905	COG0737	Belongs to the 5'-nucleotidase family
I6I41_RS00910	COG1757	Na H antiporter
I6I41_RS00920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I41_RS00935	COG1073	alpha beta
I6I41_RS00935	COG2226	methyltransferase
I6I41_RS00965	COG0307	riboflavin synthase, alpha
I6I41_RS00970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I41_RS00970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I41_RS00985	COG1073	alpha beta
I6I41_RS00990	COG0456	acetyltransferase
I6I41_RS00995	COG1609	Transcriptional regulator
I6I41_RS01000	COG2056	Na+-H+ antiporter family
I6I41_RS01005	COG0596	Alpha beta hydrolase
I6I41_RS01015	COG4085	toxin activity
I6I41_RS01015	COG1525	nuclease
I6I41_RS01015	COG0737	Belongs to the 5'-nucleotidase family
I6I41_RS01025	COG0456	acetyltransferase
I6I41_RS01025	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I41_RS01030	COG0656	L-ascorbic acid biosynthetic process
I6I41_RS01035	COG0667	Aldo Keto reductase
I6I41_RS01055	COG1300	Membrane
I6I41_RS01060	COG0735	belongs to the Fur family
I6I41_RS01070	COG4974	Belongs to the 'phage' integrase family
I6I41_RS01095	COG0598	Magnesium transport protein CorA
I6I41_RS01110	COG1846	Transcriptional regulator
I6I41_RS01130	COG1131	(ABC) transporter
I6I41_RS01135	COG1725	Transcriptional regulator
I6I41_RS01140	COG1686	Belongs to the peptidase S11 family
I6I41_RS01160	COG0733	neurotransmitter:sodium symporter activity
I6I41_RS01185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I41_RS01200	COG0697	spore germination
I6I41_RS01205	COG0561	phosphatase activity
I6I41_RS01210	COG4086	secreted protein
I6I41_RS01215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I41_RS01220	COG0456	acetyltransferase
I6I41_RS01225	COG1547	Domain of unknown function (DUF309)
I6I41_RS01250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I41_RS01260	COG2188	Transcriptional regulator
I6I41_RS01270	COG3711	transcriptional antiterminator
I6I41_RS01275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I41_RS01275	COG1263	PTS System
I6I41_RS01275	COG2190	(PTS) system
I6I41_RS01300	COG0778	Nitroreductase
I6I41_RS01305	COG2199	diguanylate cyclase activity
I6I41_RS01315	COG2084	Dehydrogenase
I6I41_RS01350	COG0436	Aminotransferase
I6I41_RS01355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I41_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS01380	COG1695	Transcriptional regulator
I6I41_RS01415	COG0183	Belongs to the thiolase family
I6I41_RS01455	COG3842	ATPase activity
I6I41_RS01460	COG0366	Alpha amylase catalytic
I6I41_RS01470	COG2182	Extracellular solute-binding protein
I6I41_RS01475	COG1175	transmembrane transport
I6I41_RS01480	COG3833	ABC-type maltose transport systems, permease component
I6I41_RS01485	COG1609	Transcriptional regulator
I6I41_RS01490	COG0436	Aminotransferase
I6I41_RS01500	COG2205	protein histidine kinase activity
I6I41_RS01510	COG3209	COG3209 Rhs family protein
I6I41_RS01530	COG2814	Major facilitator Superfamily
I6I41_RS01575	COG1408	metallophosphoesterase
I6I41_RS01580	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS01585	COG2200	EAL domain
I6I41_RS01600	COG4703	Protein of unknown function (DUF1797)
I6I41_RS01610	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I6I41_RS01620	COG0517	IMP dehydrogenase activity
I6I41_RS01625	COG0583	DNA-binding transcription factor activity
I6I41_RS01645	COG0569	domain protein
I6I41_RS01650	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I41_RS01660	COG0561	phosphatase activity
I6I41_RS01675	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I41_RS01680	COG0022	dehydrogenase e1 component
I6I41_RS01730	COG1982	Orn Lys Arg decarboxylase major
I6I41_RS01750	COG0483	inositol monophosphate 1-phosphatase activity
I6I41_RS01760	COG1217	gtp-binding protein TYPA
I6I41_RS01775	COG4896	Protein conserved in bacteria
I6I41_RS01785	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6I41_RS01790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I41_RS01800	COG0772	Belongs to the SEDS family
I6I41_RS01805	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6I41_RS01840	COG3336	cytochrome c oxidase
I6I41_RS01855	COG2340	Cysteine-rich secretory protein family
I6I41_RS01870	COG0406	alpha-ribazole phosphatase activity
I6I41_RS01875	COG3679	Belongs to the UPF0342 family
I6I41_RS01890	COG0742	ribosomal rna small subunit methyltransferase
I6I41_RS01900	COG3314	Sporulation integral membrane protein YlbJ
I6I41_RS01905	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I41_RS01910	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6I41_RS01920	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I41_RS01925	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I41_RS01940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I41_RS01960	COG0768	penicillin binding
I6I41_RS01965	COG0768	penicillin binding
I6I41_RS01985	COG0772	Belongs to the SEDS family
I6I41_RS02005	COG0849	cell division
I6I41_RS02010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I41_RS02020	COG1191	sigma factor activity
I6I41_RS02025	COG1191	sigma factor activity
I6I41_RS02030	COG1873	PFAM PRC-barrel domain
I6I41_RS02040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I41_RS02050	COG0762	integral membrane protein
I6I41_RS02055	COG2302	S4 RNA-binding domain
I6I41_RS02060	COG3599	regulation of cell shape
I6I41_RS02080	COG0564	pseudouridine synthase activity
I6I41_RS02140	COG3069	C4-dicarboxylate transmembrane transporter activity
I6I41_RS02155	COG0006	proline dipeptidase activity
I6I41_RS02165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I41_RS02170	COG1561	YicC-like family, N-terminal region
I6I41_RS02190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I41_RS02195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I41_RS02210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I41_RS02210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I41_RS02220	COG0631	protein serine/threonine phosphatase activity
I6I41_RS02225	COG0515	serine threonine protein kinase
I6I41_RS02225	COG2815	serine threonine protein kinase
I6I41_RS02235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I41_RS02240	COG1564	THIamine pyrophosphokinase
I6I41_RS02255	COG1302	Protein conserved in bacteria
I6I41_RS02260	COG1461	Dihydroxyacetone kinase
I6I41_RS02265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I41_RS02280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I41_RS02285	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS02290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I41_RS02300	COG1196	nuclear chromosome segregation
I6I41_RS02305	COG0552	protein localization to endoplasmic reticulum
I6I41_RS02315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I41_RS02325	COG1837	Belongs to the UPF0109 family
I6I41_RS02365	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I41_RS02370	COG0758	DNA mediated transformation
I6I41_RS02375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I41_RS02385	COG4974	Belongs to the 'phage' integrase family
I6I41_RS02430	COG4589	Belongs to the CDS family
I6I41_RS02440	COG0750	zinc metalloprotease
I6I41_RS02460	COG0195	Participates in both transcription termination and antitermination
I6I41_RS02465	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6I41_RS02470	COG1358	cellular component organization or biogenesis
I6I41_RS02480	COG1550	Protein conserved in bacteria
I6I41_RS02485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I41_RS02495	COG0196	riboflavin kinase activity
I6I41_RS02510	COG0726	polysaccharide deacetylase
I6I41_RS02515	COG0612	Peptidase, M16
I6I41_RS02520	COG1873	PFAM PRC-barrel domain
I6I41_RS02525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I41_RS02530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I41_RS02535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I41_RS02540	COG0527	aspartate kinase activity
I6I41_RS02550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I41_RS02555	COG0740	serine-type endopeptidase activity
I6I41_RS02570	COG2188	Transcriptional regulator
I6I41_RS02575	COG1744	ABC transporter substrate-binding protein PnrA-like
I6I41_RS02580	COG3845	ABC transporter
I6I41_RS02585	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I41_RS02590	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I41_RS02595	COG0612	Peptidase, M16
I6I41_RS02600	COG0612	Peptidase, M16
I6I41_RS02605	COG0300	oxidoreductase activity
I6I41_RS02620	COG1426	Protein conserved in bacteria
I6I41_RS02625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I41_RS02645	COG1692	metallophosphoesterase
I6I41_RS02650	COG2359	stage V sporulation protein S
I6I41_RS02660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6I41_RS02660	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6I41_RS02665	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6I41_RS02675	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6I41_RS02700	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6I41_RS02705	COG1368	sulfuric ester hydrolase activity
I6I41_RS02715	COG3773	Cell wall hydrolase
I6I41_RS02720	COG1404	Belongs to the peptidase S8 family
I6I41_RS02730	COG2723	6-phospho-beta-galactosidase activity
I6I41_RS02735	COG2188	Transcriptional regulator
I6I41_RS02745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I41_RS02755	COG1346	cytolysis
I6I41_RS02795	COG5001	Diguanylate cyclase
I6I41_RS02795	COG3300	MHYT domain
I6I41_RS02800	COG2267	carboxylic ester hydrolase activity
I6I41_RS02815	COG2364	Membrane
I6I41_RS02825	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6I41_RS02830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I41_RS02835	COG2169	Transcriptional regulator
I6I41_RS02845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I41_RS02850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I41_RS02855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I41_RS02860	COG1120	ATPase activity
I6I41_RS02865	COG2819	hydrolase of the alpha beta superfamily
I6I41_RS02875	COG1937	Protein conserved in bacteria
I6I41_RS02880	COG2608	mercury ion transmembrane transporter activity
I6I41_RS02885	COG2217	Heavy metal translocating P-type atpase
I6I41_RS02900	COG2116	formate transmembrane transporter activity
I6I41_RS02905	COG1408	metallophosphoesterase
I6I41_RS02915	COG1113	amino acid transport
I6I41_RS02925	COG2322	membrane
I6I41_RS02930	COG1979	alcohol dehydrogenase
I6I41_RS02935	COG1349	DNA-binding transcription factor activity
I6I41_RS02940	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I41_RS02945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I41_RS02945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I41_RS02945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I41_RS02950	COG3584	3D domain protein
I6I41_RS02950	COG1388	LysM domain
I6I41_RS02980	COG0464	growth
I6I41_RS02990	COG2860	membrane
I6I41_RS02995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I41_RS03000	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6I41_RS03005	COG0789	Transcriptional regulator
I6I41_RS03010	COG0174	glutamine synthetase
I6I41_RS03015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I41_RS03045	COG0741	lytic transglycosylase activity
I6I41_RS03050	COG0739	heme binding
I6I41_RS03055	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6I41_RS03055	COG3409	Peptidoglycan-binding domain 1 protein
I6I41_RS03055	COG1388	LysM domain
I6I41_RS03065	COG1695	Transcriptional regulator
I6I41_RS03085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6I41_RS03095	COG0737	Belongs to the 5'-nucleotidase family
I6I41_RS03100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I41_RS03110	COG3639	organic phosphonate transmembrane transporter activity
I6I41_RS03135	COG1132	(ABC) transporter
I6I41_RS03140	COG1132	(ABC) transporter
I6I41_RS03165	COG0730	response to heat
I6I41_RS03180	COG1346	cytolysis
I6I41_RS03190	COG0583	DNA-binding transcription factor activity
I6I41_RS03205	COG1131	(ABC) transporter
I6I41_RS03215	COG1473	amidohydrolase
I6I41_RS03225	COG0785	Cytochrome C biogenesis protein
I6I41_RS03230	COG4846	Membrane protein involved in cytochrome C biogenesis
I6I41_RS03280	COG0010	Belongs to the arginase family
I6I41_RS03285	COG1329	Transcriptional regulator
I6I41_RS03290	COG1902	pentaerythritol trinitrate reductase activity
I6I41_RS03295	COG0069	glutamate synthase activity
I6I41_RS03305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I41_RS03310	COG0346	lactoylglutathione lyase activity
I6I41_RS03315	COG0400	carboxylic ester hydrolase activity
I6I41_RS03320	COG5002	protein histidine kinase activity
I6I41_RS03330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I41_RS03375	COG0318	PFAM AMP-dependent synthetase and ligase
I6I41_RS03380	COG1268	BioY protein
I6I41_RS03385	COG0318	PFAM AMP-dependent synthetase and ligase
I6I41_RS03390	COG0183	Belongs to the thiolase family
I6I41_RS03405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I41_RS03415	COG2211	Major facilitator Superfamily
I6I41_RS03445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I41_RS03450	COG1122	ATPase activity
I6I41_RS03465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I41_RS03495	COG0824	Thioesterase
I6I41_RS03500	COG4841	protein insertion into membrane
I6I41_RS03520	COG0745	RESPONSE REGULATOR receiver
I6I41_RS03525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I41_RS03530	COG1832	CoA-binding protein
I6I41_RS03535	COG0187	DNA topoisomerase II activity
I6I41_RS03540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I41_RS03545	COG0673	inositol 2-dehydrogenase activity
I6I41_RS03555	COG1131	(ABC) transporter
I6I41_RS03565	COG1595	DNA-templated transcription, initiation
I6I41_RS03575	COG1316	TRANSCRIPTIONal
I6I41_RS03580	COG1301	dicarboxylic acid transport
I6I41_RS03585	COG4166	transmembrane transport
I6I41_RS03590	COG4166	transmembrane transport
I6I41_RS03595	COG4166	transmembrane transport
I6I41_RS03600	COG2226	methyltransferase
I6I41_RS03635	COG0531	amino acid
I6I41_RS03650	COG0697	spore germination
I6I41_RS03655	COG3383	formate dehydrogenase (NAD+) activity
I6I41_RS03660	COG2427	Protein of unknown function (DUF1641)
I6I41_RS03665	COG5609	conserved protein (DUF2294)
I6I41_RS03670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I41_RS03680	COG2116	formate transmembrane transporter activity
I6I41_RS03685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I41_RS03690	COG0303	'Molybdopterin
I6I41_RS03695	COG0314	molybdopterin synthase activity
I6I41_RS03705	COG0489	protein tyrosine kinase activity
I6I41_RS03720	COG3326	Membrane
I6I41_RS03725	COG2962	Rard protein
I6I41_RS03730	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I6I41_RS03735	COG1657	PFAM Prenyltransferase squalene oxidase
I6I41_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS03750	COG1012	belongs to the aldehyde dehydrogenase family
I6I41_RS03760	COG4145	pantothenate transmembrane transporter activity
I6I41_RS03775	COG0165	Argininosuccinate lyase
I6I41_RS03785	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS03805	COG0494	nUDIX hydrolase
I6I41_RS03815	COG0716	FMN binding
I6I41_RS03850	COG2720	vancomycin resistance protein
I6I41_RS03855	COG2514	catechol 2,3-dioxygenase activity
I6I41_RS03865	COG1285	pathogenesis
I6I41_RS03875	COG3852	Histidine kinase
I6I41_RS03905	COG0488	(ABC) transporter
I6I41_RS03965	COG0457	Tetratricopeptide repeat
I6I41_RS03975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I41_RS03985	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I41_RS04005	COG0697	spore germination
I6I41_RS04015	COG3397	chitin binding
I6I41_RS04020	COG0823	Involved in the tonB-independent uptake of proteins
I6I41_RS04030	COG1252	NADH dehydrogenase
I6I41_RS04035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS04035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I41_RS04040	COG1183	phosphatidylcholine synthase activity
I6I41_RS04065	COG0277	FAD linked oxidase domain protein
I6I41_RS04080	COG0457	Tetratricopeptide repeat
I6I41_RS04090	COG0604	alcohol dehydrogenase
I6I41_RS04095	COG0640	Transcriptional regulator
I6I41_RS04105	COG0584	glycerophosphoryl diester phosphodiesterase
I6I41_RS04130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I41_RS04170	COG1164	Oligoendopeptidase f
I6I41_RS04175	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6I41_RS04185	COG1193	negative regulation of DNA recombination
I6I41_RS04205	COG0583	DNA-binding transcription factor activity
I6I41_RS04220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS04240	COG3739	integral membrane protein
I6I41_RS04245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I41_RS04250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I41_RS04255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I41_RS04260	COG1247	-acetyltransferase
I6I41_RS04270	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I41_RS04275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6I41_RS04310	COG2814	Major facilitator Superfamily
I6I41_RS04315	COG1113	amino acid transport
I6I41_RS04350	COG2072	flavoprotein involved in K transport
I6I41_RS04380	COG1151	hydroxylamine reductase activity
I6I41_RS04390	COG3209	COG3209 Rhs family protein
I6I41_RS04450	COG1191	sigma factor activity
I6I41_RS04475	COG1733	regulation of RNA biosynthetic process
I6I41_RS04480	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I41_RS04485	COG0318	PFAM AMP-dependent synthetase and ligase
I6I41_RS04495	COG0384	phenazine biosynthesis protein PhzF
I6I41_RS04520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS04540	COG0673	inositol 2-dehydrogenase activity
I6I41_RS04545	COG2188	Transcriptional regulator
I6I41_RS04575	COG0814	amino acid
I6I41_RS04610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I41_RS04615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I41_RS04620	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6I41_RS04625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I41_RS04635	COG1070	Carbohydrate kinase
I6I41_RS04640	COG2706	6-phosphogluconolactonase activity
I6I41_RS04645	COG3813	Protein conserved in bacteria
I6I41_RS04650	COG1357	PFAM Pentapeptide repeats (8 copies)
I6I41_RS04660	COG0697	spore germination
I6I41_RS04685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I41_RS04695	COG0789	Transcriptional regulator
I6I41_RS04700	COG1253	flavin adenine dinucleotide binding
I6I41_RS04740	COG0500	methyltransferase
I6I41_RS04770	COG0628	permease
I6I41_RS04805	COG2365	Tyrosine phosphatase family
I6I41_RS04810	COG1011	Hydrolase
I6I41_RS04835	COG1131	(ABC) transporter
I6I41_RS04845	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS04865	COG0469	pyruvate kinase activity
I6I41_RS04875	COG0778	Nitroreductase
I6I41_RS04880	COG1733	regulation of RNA biosynthetic process
I6I41_RS04900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I41_RS04920	COG2356	endonuclease I
I6I41_RS04925	COG1288	antiporter activity
I6I41_RS04980	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I41_RS04990	COG2031	fatty acid transporter
I6I41_RS05000	COG2814	Major facilitator Superfamily
I6I41_RS05005	COG1846	Transcriptional regulator
I6I41_RS05020	COG0477	Major facilitator Superfamily
I6I41_RS05030	COG2843	Capsule synthesis protein
I6I41_RS05035	COG1876	peptidase activity
I6I41_RS05110	COG5444	nuclease activity
I6I41_RS05160	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6I41_RS05160	COG3409	Peptidoglycan-binding domain 1 protein
I6I41_RS05200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I41_RS05235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I41_RS05240	COG2808	Putative FMN-binding domain
I6I41_RS05245	COG0456	acetyltransferase
I6I41_RS05250	COG1846	Transcriptional regulator
I6I41_RS05255	COG2364	Membrane
I6I41_RS05265	COG5002	protein histidine kinase activity
I6I41_RS05265	COG3850	Histidine kinase
I6I41_RS05285	COG0577	efflux transmembrane transporter activity
I6I41_RS05305	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6I41_RS05310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I41_RS05320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I41_RS05325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS05350	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I41_RS05365	COG2814	Major facilitator Superfamily
I6I41_RS05400	COG1136	(ABC) transporter
I6I41_RS05410	COG0277	FAD linked oxidase domain protein
I6I41_RS05450	COG5002	protein histidine kinase activity
I6I41_RS05450	COG3850	Histidine kinase
I6I41_RS05455	COG0745	RESPONSE REGULATOR receiver
I6I41_RS05480	COG0346	lactoylglutathione lyase activity
I6I41_RS05500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I41_RS05500	COG3320	Male sterility
I6I41_RS05510	COG0640	Transcriptional regulator
I6I41_RS05515	COG0346	lactoylglutathione lyase activity
I6I41_RS05520	COG0798	PFAM Bile acid sodium symporter
I6I41_RS05530	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I41_RS05535	COG0456	acetyltransferase
I6I41_RS05545	COG5294	Protein conserved in bacteria
I6I41_RS05550	COG0583	DNA-binding transcription factor activity
I6I41_RS05555	COG2814	Major facilitator Superfamily
I6I41_RS05565	COG2814	Major facilitator Superfamily
I6I41_RS05570	COG5609	conserved protein (DUF2294)
I6I41_RS05575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I41_RS05585	COG0288	reversible hydration of carbon dioxide
I6I41_RS05590	COG0657	acetylesterase activity
I6I41_RS05600	COG2814	Major facilitator Superfamily
I6I41_RS05610	COG0415	Belongs to the DNA photolyase family
I6I41_RS05630	COG1073	alpha beta
I6I41_RS05650	COG0598	Magnesium transport protein CorA
I6I41_RS05660	COG0583	DNA-binding transcription factor activity
I6I41_RS05680	COG1335	isochorismatase
I6I41_RS05685	COG2267	carboxylic ester hydrolase activity
I6I41_RS05690	COG0737	Belongs to the 5'-nucleotidase family
I6I41_RS05715	COG1115	amino acid carrier protein
I6I41_RS05720	COG2066	Belongs to the glutaminase family
I6I41_RS05725	COG4191	Histidine kinase
I6I41_RS05730	COG0784	Response regulator, receiver
I6I41_RS05735	COG0697	spore germination
I6I41_RS05740	COG0531	amino acid
I6I41_RS05750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I41_RS05755	COG0531	amino acid
I6I41_RS05760	COG0322	excinuclease ABC activity
I6I41_RS05775	COG2207	Transcriptional regulator
I6I41_RS05800	COG5002	protein histidine kinase activity
I6I41_RS05835	COG1396	sequence-specific DNA binding
I6I41_RS05840	COG0252	asparaginase activity
I6I41_RS05845	COG1027	Aspartate ammonia-lyase
I6I41_RS05850	COG1063	alcohol dehydrogenase
I6I41_RS05870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS05875	COG3848	Pyruvate phosphate dikinase
I6I41_RS05875	COG0574	Belongs to the PEP-utilizing enzyme family
I6I41_RS05900	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I6I41_RS05920	COG3314	Sporulation integral membrane protein YlbJ
I6I41_RS05935	COG1960	acyl-CoA dehydrogenase activity
I6I41_RS05945	COG0640	Transcriptional regulator
I6I41_RS05960	COG1414	Transcriptional regulator
I6I41_RS05965	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I41_RS05970	COG1984	allophanate hydrolase subunit 2
I6I41_RS06000	COG0768	penicillin binding
I6I41_RS06040	COG4335	DNA alkylation repair
I6I41_RS06050	COG0833	amino acid
I6I41_RS06060	COG0730	response to heat
I6I41_RS06110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I41_RS06115	COG0697	spore germination
I6I41_RS06130	COG0456	acetyltransferase
I6I41_RS06155	COG4884	unkown
I6I41_RS06155	COG3831	ATPase activity
I6I41_RS06175	COG1846	Transcriptional regulator
I6I41_RS06180	COG0778	Nitroreductase
I6I41_RS06245	COG0714	Associated with various cellular activities
I6I41_RS06285	COG0753	catalase activity
I6I41_RS06290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I41_RS06320	COG0463	Glycosyl transferase, family 2
I6I41_RS06345	COG0714	Associated with various cellular activities
I6I41_RS06370	COG0346	lactoylglutathione lyase activity
I6I41_RS06375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS06395	COG3655	Transcriptional regulator
I6I41_RS06405	COG1785	Belongs to the alkaline phosphatase family
I6I41_RS06410	COG2720	vancomycin resistance protein
I6I41_RS06420	COG3239	Fatty acid desaturase
I6I41_RS06430	COG0833	amino acid
I6I41_RS06435	COG1414	Transcriptional regulator
I6I41_RS06440	COG4187	Peptidase family M20/M25/M40
I6I41_RS06445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I41_RS06460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I41_RS06480	COG2329	Antibiotic biosynthesis monooxygenase
I6I41_RS06500	COG1070	Carbohydrate kinase
I6I41_RS06505	COG2390	Transcriptional regulator
I6I41_RS06515	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I41_RS06520	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I41_RS06525	COG1879	ABC-type sugar transport system periplasmic component
I6I41_RS06550	COG0277	FAD linked oxidase domain protein
I6I41_RS06555	COG0346	lactoylglutathione lyase activity
I6I41_RS06565	COG1388	LysM domain
I6I41_RS06565	COG3584	3D domain protein
I6I41_RS06605	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6I41_RS06605	COG1605	Chorismate mutase
I6I41_RS06620	COG0287	Prephenate dehydrogenase
I6I41_RS06635	COG1309	transcriptional regulator
I6I41_RS06640	COG2409	Drug exporters of the RND superfamily
I6I41_RS06640	COG1033	growth of symbiont in host cell
I6I41_RS06645	COG0488	(ABC) transporter
I6I41_RS06650	COG1368	sulfuric ester hydrolase activity
I6I41_RS06655	COG0861	Integral membrane protein TerC family
I6I41_RS06675	COG0346	lactoylglutathione lyase activity
I6I41_RS06680	COG4912	Dna alkylation repair
I6I41_RS06700	COG2318	DinB family
I6I41_RS06705	COG0697	spore germination
I6I41_RS06715	COG2746	aminoglycoside 3-N-acetyltransferase activity
I6I41_RS06755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I41_RS06760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I41_RS06765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I41_RS06775	COG0628	permease
I6I41_RS06825	COG1131	(ABC) transporter
I6I41_RS06840	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6I41_RS06850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I41_RS06855	COG0436	Aminotransferase
I6I41_RS06890	COG2226	methyltransferase
I6I41_RS06905	COG2261	transglycosylase associated protein
I6I41_RS06925	COG2814	Major facilitator Superfamily
I6I41_RS06925	COG0477	Major facilitator Superfamily
I6I41_RS06930	COG4533	DNA binding
I6I41_RS06935	COG0789	Transcriptional regulator
I6I41_RS06940	COG1664	Polymer-forming cytoskeletal
I6I41_RS06950	COG2814	Major facilitator Superfamily
I6I41_RS06990	COG1307	EDD domain protein, DegV family
I6I41_RS06995	COG1164	Oligoendopeptidase f
I6I41_RS07030	COG0745	RESPONSE REGULATOR receiver
I6I41_RS07035	COG3850	Histidine kinase
I6I41_RS07035	COG5002	protein histidine kinase activity
I6I41_RS07080	COG0667	Aldo Keto reductase
I6I41_RS07095	COG4948	Mandelate Racemase Muconate Lactonizing
I6I41_RS07105	COG4166	transmembrane transport
I6I41_RS07115	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6I41_RS07125	COG0586	Pfam SNARE associated Golgi protein
I6I41_RS07130	COG1078	dGTPase activity
I6I41_RS07175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I41_RS07180	COG3938	Belongs to the proline racemase family
I6I41_RS07190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I41_RS07195	COG1012	belongs to the aldehyde dehydrogenase family
I6I41_RS07200	COG1115	amino acid carrier protein
I6I41_RS07205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I41_RS07210	COG1162	GTPase activity
I6I41_RS07225	COG3397	chitin binding
I6I41_RS07240	COG4637	Psort location Cytoplasmic, score
I6I41_RS07280	COG0514	ATP-dependent DNA helicase (RecQ)
I6I41_RS07295	COG3973	AAA domain
I6I41_RS07340	COG2315	Protein conserved in bacteria
I6I41_RS07345	COG2226	methyltransferase
I6I41_RS07350	COG2205	protein histidine kinase activity
I6I41_RS07370	COG1819	glycosyl
I6I41_RS07375	COG3397	chitin binding
I6I41_RS07380	COG2153	protein acetylation
I6I41_RS07410	COG0517	IMP dehydrogenase activity
I6I41_RS07410	COG4175	Glycine betaine
I6I41_RS07415	COG4176	ABC-type proline glycine betaine transport system permease component
I6I41_RS07455	COG0456	acetyltransferase
I6I41_RS07455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I41_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS07470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I41_RS07475	COG0022	dehydrogenase e1 component
I6I41_RS07480	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I41_RS07485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I41_RS07500	COG1959	2 iron, 2 sulfur cluster binding
I6I41_RS07515	COG1349	DNA-binding transcription factor activity
I6I41_RS07530	COG3284	Transcriptional regulator
I6I41_RS07560	COG1309	transcriptional regulator
I6I41_RS07600	COG2959	enzyme of heme biosynthesis
I6I41_RS07615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS07645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I41_RS07655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I41_RS07660	COG0697	spore germination
I6I41_RS07665	COG0201	protein transport
I6I41_RS07680	COG0737	Belongs to the 5'-nucleotidase family
I6I41_RS07685	COG3227	Zinc metalloprotease (Elastase)
I6I41_RS07690	COG1523	belongs to the glycosyl hydrolase 13 family
I6I41_RS07705	COG0076	glutamate decarboxylase activity
I6I41_RS07710	COG0657	acetylesterase activity
I6I41_RS07715	COG1073	alpha beta
I6I41_RS07720	COG0577	efflux transmembrane transporter activity
I6I41_RS07725	COG1136	(ABC) transporter
I6I41_RS07740	COG5002	protein histidine kinase activity
I6I41_RS07745	COG0745	RESPONSE REGULATOR receiver
I6I41_RS07750	COG1011	Hydrolase
I6I41_RS07785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I41_RS07825	COG0322	excinuclease ABC activity
I6I41_RS07865	COG4667	esterase of the alpha-beta hydrolase superfamily
I6I41_RS07890	COG3878	Protein conserved in bacteria
I6I41_RS07910	COG0592	DNA-directed DNA polymerase activity
I6I41_RS07925	COG2223	nitrite transmembrane transporter activity
I6I41_RS07935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I41_RS07970	COG0697	spore germination
I6I41_RS07975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I41_RS07995	COG0584	glycerophosphoryl diester phosphodiesterase
I6I41_RS08015	COG4978	Transcriptional regulator
I6I41_RS08015	COG0789	Transcriptional regulator
I6I41_RS08020	COG2814	Major facilitator Superfamily
I6I41_RS08075	COG0768	penicillin binding
I6I41_RS08080	COG0671	phosphoesterase, PA-phosphatase related
I6I41_RS08085	COG0604	alcohol dehydrogenase
I6I41_RS08090	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I41_RS08130	COG0582	viral genome integration into host DNA
I6I41_RS08135	COG2205	protein histidine kinase activity
I6I41_RS08160	COG1794	racemase activity, acting on amino acids and derivatives
I6I41_RS08165	COG1819	glycosyl
I6I41_RS08175	COG0768	penicillin binding
I6I41_RS08180	COG5002	protein histidine kinase activity
I6I41_RS08185	COG0561	phosphatase activity
I6I41_RS08220	COG2124	cytochrome p450
I6I41_RS08280	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I41_RS08290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I41_RS08295	COG0460	homoserine dehydrogenase
I6I41_RS08315	COG0577	efflux transmembrane transporter activity
I6I41_RS08320	COG1136	(ABC) transporter
I6I41_RS08330	COG0825	malonyl-CoA metabolic process
I6I41_RS08345	COG0488	(ABC) transporter
I6I41_RS08355	COG2205	protein histidine kinase activity
I6I41_RS08360	COG0745	RESPONSE REGULATOR receiver
I6I41_RS08370	COG3773	Cell wall hydrolase
I6I41_RS08385	COG3386	PFAM SMP-30 Gluconolaconase
I6I41_RS08400	COG2323	membrane
I6I41_RS08410	COG1063	alcohol dehydrogenase
I6I41_RS08425	COG2368	4-hydroxyphenylacetate
I6I41_RS08435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I41_RS08480	COG1733	regulation of RNA biosynthetic process
I6I41_RS08485	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS08490	COG2814	Major facilitator Superfamily
I6I41_RS08500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I41_RS08530	COG2207	Transcriptional regulator
I6I41_RS08535	COG3227	Zinc metalloprotease (Elastase)
I6I41_RS08550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I41_RS08575	COG1686	Belongs to the peptidase S11 family
I6I41_RS08595	COG0572	uridine kinase
I6I41_RS08625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I41_RS08630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I41_RS08635	COG1024	Enoyl-CoA hydratase
I6I41_RS08640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I41_RS08645	COG0511	ligase activity, forming carbon-carbon bonds
I6I41_RS08650	COG0439	Biotin carboxylase
I6I41_RS08655	COG1960	acyl-CoA dehydrogenase activity
I6I41_RS08670	COG1309	transcriptional regulator
I6I41_RS08680	COG1131	(ABC) transporter
I6I41_RS08690	COG1408	metallophosphoesterase
I6I41_RS08700	COG0768	penicillin binding
I6I41_RS08705	COG0768	penicillin binding
I6I41_RS08715	COG1595	DNA-templated transcription, initiation
I6I41_RS08720	COG0768	penicillin binding
I6I41_RS08725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I41_RS08780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS08785	COG0741	lytic transglycosylase activity
I6I41_RS08840	COG2814	Major facilitator Superfamily
I6I41_RS08855	COG1686	Belongs to the peptidase S11 family
I6I41_RS08860	COG0110	maltose O-acetyltransferase activity
I6I41_RS08865	COG0730	response to heat
I6I41_RS08875	COG2002	toxin-antitoxin pair type II binding
I6I41_RS08905	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I41_RS08935	COG1846	Transcriptional regulator
I6I41_RS08940	COG3961	Belongs to the TPP enzyme family
I6I41_RS08945	COG2226	methyltransferase
I6I41_RS08955	COG0500	methyltransferase
I6I41_RS08955	COG3615	Tellurite resistance protein tehB
I6I41_RS08975	COG1309	transcriptional regulator
I6I41_RS08995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS09010	COG1846	Transcriptional regulator
I6I41_RS09030	COG2971	BadF BadG BcrA BcrD
I6I41_RS09055	COG1649	PFAM Uncharacterised BCR, COG1649
I6I41_RS09080	COG1595	DNA-templated transcription, initiation
I6I41_RS09085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I41_RS09115	COG1396	sequence-specific DNA binding
I6I41_RS09145	COG1132	(ABC) transporter
I6I41_RS09150	COG1132	(ABC) transporter
I6I41_RS09165	COG2258	MOSC domain
I6I41_RS09170	COG0583	DNA-binding transcription factor activity
I6I41_RS09190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I41_RS09195	COG0583	DNA-binding transcription factor activity
I6I41_RS09225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS09235	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6I41_RS09260	COG1247	-acetyltransferase
I6I41_RS09290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS09315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I41_RS09355	COG0028	Belongs to the TPP enzyme family
I6I41_RS09380	COG1136	(ABC) transporter
I6I41_RS09385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I41_RS09390	COG1187	pseudouridine synthase activity
I6I41_RS09415	COG1115	amino acid carrier protein
I6I41_RS09425	COG2318	DinB family
I6I41_RS09435	COG0776	regulation of translation
I6I41_RS09450	COG2814	Major facilitator Superfamily
I6I41_RS09455	COG3251	PFAM MbtH domain protein
I6I41_RS09460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I41_RS09465	COG3433	isochorismatase activity
I6I41_RS09465	COG1535	isochorismatase
I6I41_RS09470	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6I41_RS09475	COG1169	isochorismate synthase
I6I41_RS09480	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS09485	COG2223	nitrite transmembrane transporter activity
I6I41_RS09510	COG0419	ATPase involved in DNA repair
I6I41_RS09515	COG0420	3'-5' exonuclease activity
I6I41_RS09530	COG1024	Enoyl-CoA hydratase
I6I41_RS09535	COG1280	lysine exporter protein (LysE YggA)
I6I41_RS09545	COG2084	Dehydrogenase
I6I41_RS09550	COG1960	acyl-CoA dehydrogenase activity
I6I41_RS09555	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6I41_RS09560	COG2079	MmgE PrpD family protein
I6I41_RS09565	COG0372	Belongs to the citrate synthase family
I6I41_RS09570	COG4841	protein insertion into membrane
I6I41_RS09575	COG2814	Major facilitator Superfamily
I6I41_RS09585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I41_RS09585	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6I41_RS09605	COG0300	oxidoreductase activity
I6I41_RS09685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I41_RS09690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I41_RS09695	COG0671	phosphoesterase, PA-phosphatase related
I6I41_RS09705	COG4991	sh3 domain protein
I6I41_RS09705	COG0515	serine threonine protein kinase
I6I41_RS09705	COG3064	Membrane
I6I41_RS09740	COG1509	lysine 2,3-aminomutase activity
I6I41_RS09745	COG3829	transcription factor binding
I6I41_RS09750	COG0456	acetyltransferase
I6I41_RS09755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I41_RS09760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I41_RS09765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I41_RS09770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I41_RS09785	COG5506	Protein of unknown function (DUF1694)
I6I41_RS09790	COG1012	belongs to the aldehyde dehydrogenase family
I6I41_RS09795	COG1253	flavin adenine dinucleotide binding
I6I41_RS09830	COG1174	glycine betaine transport
I6I41_RS09835	COG1125	glycine betaine transport
I6I41_RS09835	COG0517	IMP dehydrogenase activity
I6I41_RS09870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6I41_RS09895	COG2801	Transposase and inactivated derivatives
I6I41_RS09905	COG1064	alcohol dehydrogenase
I6I41_RS09910	COG0384	phenazine biosynthesis protein PhzF
I6I41_RS09915	COG1737	Transcriptional regulator
I6I41_RS09920	COG2197	response regulator
I6I41_RS09925	COG2203	Gaf domain
I6I41_RS09925	COG4585	Histidine kinase
I6I41_RS09930	COG0668	transmembrane transport
I6I41_RS09945	COG1335	isochorismatase
I6I41_RS09965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I41_RS09970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I41_RS09975	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I41_RS09990	COG0367	asparagine synthase
I6I41_RS09995	COG0071	Belongs to the small heat shock protein (HSP20) family
I6I41_RS10000	COG1999	signal sequence binding
I6I41_RS10010	COG1307	EDD domain protein, DegV family
I6I41_RS10020	COG0805	protein transport
I6I41_RS10030	COG1272	protein, Hemolysin III
I6I41_RS10035	COG0204	Acyl-transferase
I6I41_RS10045	COG0768	penicillin binding
I6I41_RS10060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I41_RS10075	COG0546	phosphoglycolate phosphatase activity
I6I41_RS10085	COG4473	ABC transporter
I6I41_RS10090	COG1131	(ABC) transporter
I6I41_RS10100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I41_RS10105	COG3655	Transcriptional regulator
I6I41_RS10115	COG0456	acetyltransferase
I6I41_RS10125	COG1794	racemase activity, acting on amino acids and derivatives
I6I41_RS10135	COG2610	gluconate transmembrane transporter activity
I6I41_RS10160	COG0733	neurotransmitter:sodium symporter activity
I6I41_RS10165	COG0017	Asparaginyl-tRNA synthetase
I6I41_RS10215	COG0018	arginyl-trna synthetase
I6I41_RS10220	COG2136	Putative SAM-dependent methyltransferase
I6I41_RS10220	COG2521	methyltransferase
I6I41_RS10235	COG1413	lyase activity
I6I41_RS10245	COG0629	single-stranded DNA binding
I6I41_RS10260	COG0488	(ABC) transporter
I6I41_RS10265	COG1418	mRNA catabolic process
I6I41_RS10280	COG0457	Tetratricopeptide repeat
I6I41_RS10300	COG2801	Transposase and inactivated derivatives
I6I41_RS10315	COG2359	stage V sporulation protein S
I6I41_RS10350	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6I41_RS10355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I41_RS10360	COG2146	nitrite reductase [NAD(P)H] activity
I6I41_RS10365	COG1587	Uroporphyrinogen-III synthase
I6I41_RS10365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I41_RS10375	COG1648	precorrin-2 dehydrogenase activity
I6I41_RS10395	COG2223	nitrite transmembrane transporter activity
I6I41_RS10405	COG0314	molybdopterin synthase activity
I6I41_RS10410	COG0303	'Molybdopterin
I6I41_RS10415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I41_RS10420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I41_RS10425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I41_RS10430	COG2181	nitrate reductase activity
I6I41_RS10435	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6I41_RS10440	COG1140	nitrate reductase beta subunit
I6I41_RS10445	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6I41_RS10450	COG0714	Associated with various cellular activities
I6I41_RS10455	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I6I41_RS10460	COG1305	Transglutaminase-like
I6I41_RS10465	COG0386	Belongs to the glutathione peroxidase family
I6I41_RS10490	COG1595	DNA-templated transcription, initiation
I6I41_RS10495	COG0604	alcohol dehydrogenase
I6I41_RS10505	COG0346	lactoylglutathione lyase activity
I6I41_RS10530	COG2226	methyltransferase
I6I41_RS10555	COG3874	Sporulation protein YtfJ
I6I41_RS10645	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6I41_RS10680	COG0456	acetyltransferase
I6I41_RS10710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I41_RS10715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I41_RS10720	COG1819	glycosyl
I6I41_RS10735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I41_RS10750	COG0561	phosphatase activity
I6I41_RS10760	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I41_RS10775	COG2211	Major facilitator Superfamily
I6I41_RS10780	COG0154	amidase activity
I6I41_RS10790	COG1876	peptidase activity
I6I41_RS10800	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I41_RS10820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I41_RS10825	COG1114	Component of the transport system for branched-chain amino acids
I6I41_RS10840	COG1253	flavin adenine dinucleotide binding
I6I41_RS10845	COG2839	Protein conserved in bacteria
I6I41_RS10850	COG0702	epimerase
I6I41_RS10865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I41_RS10875	COG1607	acyl-coa hydrolase
I6I41_RS10880	COG3689	TIGRFAM TIGR03943 family protein
I6I41_RS10885	COG0701	Predicted permease
I6I41_RS10895	COG2244	polysaccharide biosynthetic process
I6I41_RS10900	COG0586	Pfam SNARE associated Golgi protein
I6I41_RS10905	COG1051	belongs to the nudix hydrolase family
I6I41_RS10910	COG5337	Spore coat protein CotH
I6I41_RS10935	COG4166	transmembrane transport
I6I41_RS10945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I41_RS10955	COG0702	epimerase
I6I41_RS10965	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I41_RS10970	COG0456	acetyltransferase
I6I41_RS10975	COG0523	cobalamin synthesis protein
I6I41_RS10980	COG4989	oxidoreductase activity
I6I41_RS10985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS10990	COG1231	oxidoreductase activity
I6I41_RS11000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I41_RS11015	COG0783	Belongs to the Dps family
I6I41_RS11020	COG3949	Membrane
I6I41_RS11035	COG0840	transmembrane signaling receptor activity
I6I41_RS11060	COG3152	Membrane
I6I41_RS11065	COG2814	Major facilitator Superfamily
I6I41_RS11070	COG0667	Aldo Keto reductase
I6I41_RS11075	COG0640	Transcriptional regulator
I6I41_RS11080	COG1404	Belongs to the peptidase S8 family
I6I41_RS11085	COG2002	toxin-antitoxin pair type II binding
I6I41_RS11090	COG0577	efflux transmembrane transporter activity
I6I41_RS11125	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I41_RS11135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I41_RS11140	COG1279	arginine transmembrane transporter activity
I6I41_RS11145	COG2814	Major facilitator Superfamily
I6I41_RS11155	COG1082	Xylose isomerase domain protein TIM barrel
I6I41_RS11165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I41_RS11185	COG1247	-acetyltransferase
I6I41_RS11190	COG1285	pathogenesis
I6I41_RS11205	COG5002	protein histidine kinase activity
I6I41_RS11210	COG0745	RESPONSE REGULATOR receiver
I6I41_RS11220	COG1316	TRANSCRIPTIONal
I6I41_RS11245	COG0460	homoserine dehydrogenase
I6I41_RS11275	COG0300	oxidoreductase activity
I6I41_RS11280	COG5002	protein histidine kinase activity
I6I41_RS11285	COG0745	RESPONSE REGULATOR receiver
I6I41_RS11290	COG1132	(ABC) transporter
I6I41_RS11300	COG1388	LysM domain
I6I41_RS11300	COG0791	NLP P60 protein
I6I41_RS11315	COG1686	Belongs to the peptidase S11 family
I6I41_RS11355	COG1216	Glycosyl transferase, family 2
I6I41_RS11365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I41_RS11370	COG4988	ABC transporter
I6I41_RS11375	COG1294	oxidase, subunit
I6I41_RS11380	COG1271	oxidase subunit
I6I41_RS11410	COG0583	DNA-binding transcription factor activity
I6I41_RS11430	COG0411	ABC transporter
I6I41_RS11440	COG0523	cobalamin synthesis protein
I6I41_RS11445	COG1231	oxidoreductase activity
I6I41_RS11455	COG0628	permease
I6I41_RS11465	COG0778	Nitroreductase
I6I41_RS11470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I41_RS11475	COG1959	2 iron, 2 sulfur cluster binding
I6I41_RS11480	COG0583	DNA-binding transcription factor activity
I6I41_RS11485	COG0697	spore germination
I6I41_RS11490	COG4549	nuclear export factor GLE1
I6I41_RS11495	COG1276	copper resistance
I6I41_RS11495	COG2372	response to copper ion
I6I41_RS11505	COG1114	Component of the transport system for branched-chain amino acids
I6I41_RS11525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I41_RS11575	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6I41_RS11580	COG1309	transcriptional regulator
I6I41_RS11595	COG2132	Multicopper oxidase
I6I41_RS11605	COG0006	proline dipeptidase activity
I6I41_RS11620	COG0583	DNA-binding transcription factor activity
I6I41_RS11640	COG4846	Membrane protein involved in cytochrome C biogenesis
I6I41_RS11675	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6I41_RS11680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I41_RS11690	COG2390	Transcriptional regulator
I6I41_RS11695	COG1309	transcriptional regulator
I6I41_RS11700	COG1266	CAAX protease self-immunity
I6I41_RS11710	COG0456	acetyltransferase
I6I41_RS11725	COG2309	aminopeptidase activity
I6I41_RS11755	COG0531	amino acid
I6I41_RS11760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I41_RS11775	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I41_RS11795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS11800	COG4166	transmembrane transport
I6I41_RS11820	COG0427	acetyl-CoA hydrolase
I6I41_RS11825	COG3279	Response regulator of the LytR AlgR family
I6I41_RS11835	COG3384	dioxygenase
I6I41_RS11840	COG2814	Major facilitator Superfamily
I6I41_RS11860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I41_RS11880	COG0028	Belongs to the TPP enzyme family
I6I41_RS11885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I41_RS11895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I41_RS11915	COG2323	membrane
I6I41_RS11920	COG5566	PFAM Mor transcription activator
I6I41_RS11930	COG0733	neurotransmitter:sodium symporter activity
I6I41_RS11950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I41_RS11955	COG2223	nitrite transmembrane transporter activity
I6I41_RS11960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I41_RS11970	COG0477	Major facilitator Superfamily
I6I41_RS11980	COG1695	Transcriptional regulator
I6I41_RS12025	COG3620	sequence-specific DNA binding
I6I41_RS12040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I41_RS12045	COG0784	Response regulator, receiver
I6I41_RS12050	COG4191	Histidine kinase
I6I41_RS12055	COG0281	malic enzyme
I6I41_RS12060	COG1027	Aspartate ammonia-lyase
I6I41_RS12070	COG0528	UMP kinase activity
I6I41_RS12075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I41_RS12095	COG1131	(ABC) transporter
I6I41_RS12130	COG2733	membrane
I6I41_RS12150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I41_RS12155	COG0785	Cytochrome C biogenesis protein
I6I41_RS12175	COG3340	Belongs to the peptidase S51 family
I6I41_RS12180	COG0534	Mate efflux family protein
I6I41_RS12210	COG0789	Transcriptional regulator
I6I41_RS12215	COG1757	Na H antiporter
I6I41_RS12230	COG0701	Predicted permease
I6I41_RS12235	COG0523	cobalamin synthesis protein
I6I41_RS12245	COG0697	spore germination
I6I41_RS12250	COG1802	Transcriptional regulator
I6I41_RS12280	COG0367	asparagine synthase
I6I41_RS12310	COG0406	alpha-ribazole phosphatase activity
I6I41_RS12360	COG0583	DNA-binding transcription factor activity
I6I41_RS12385	COG2329	Antibiotic biosynthesis monooxygenase
I6I41_RS12420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I41_RS12425	COG4786	Flagellar basal body rod
I6I41_RS12430	COG1419	protein localization to endoplasmic reticulum
I6I41_RS12435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I41_RS12440	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I41_RS12450	COG1987	bacterial-type flagellum assembly
I6I41_RS12455	COG1338	Plays a role in the flagellum-specific transport system
I6I41_RS12465	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I41_RS12465	COG1776	CheC inhibitor of MCP methylation
I6I41_RS12470	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I41_RS12480	COG0741	lytic transglycosylase activity
I6I41_RS12485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6I41_RS12495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I41_RS12505	COG0457	Tetratricopeptide repeat
I6I41_RS12505	COG0463	Glycosyl transferase, family 2
I6I41_RS12515	COG0784	Response regulator, receiver
I6I41_RS12515	COG0835	chemotaxis
I6I41_RS12530	COG1749	Flagellar hook protein flgE
I6I41_RS12550	COG1157	protein secretion by the type III secretion system
I6I41_RS12560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I41_RS12565	COG1766	The M ring may be actively involved in energy transduction
I6I41_RS12575	COG1558	bacterial-type flagellum-dependent cell motility
I6I41_RS12580	COG1815	bacterial-type flagellum-dependent cell motility
I6I41_RS12600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6I41_RS12605	COG1256	bacterial-type flagellum assembly
I6I41_RS12625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I41_RS12640	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I41_RS12640	COG1776	CheC inhibitor of MCP methylation
I6I41_RS12645	COG0643	Histidine kinase
I6I41_RS12645	COG2198	Histidine kinase
I6I41_RS12650	COG2201	protein-glutamate methylesterase activity
I6I41_RS12655	COG1360	Flagellar Motor Protein
I6I41_RS12660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6I41_RS12670	COG1923	regulation of RNA biosynthetic process
I6I41_RS12715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6I41_RS12720	COG2323	membrane
I6I41_RS12730	COG0789	Transcriptional regulator
I6I41_RS12730	COG4978	Transcriptional regulator
I6I41_RS12735	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I41_RS12740	COG0475	glutathione-regulated potassium exporter activity
I6I41_RS12750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I41_RS12755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I41_RS12775	COG1280	lysine exporter protein (LysE YggA)
I6I41_RS12780	COG3403	YqcI/YcgG family
I6I41_RS12815	COG0328	RNA-DNA hybrid ribonuclease activity
I6I41_RS12835	COG0454	-acetyltransferase
I6I41_RS12850	COG0438	transferase activity, transferring glycosyl groups
I6I41_RS12855	COG1215	transferase activity, transferring glycosyl groups
I6I41_RS12870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I41_RS12880	COG3944	biosynthesis protein
I6I41_RS12895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I41_RS12910	COG0754	glutathionylspermidine amidase activity
I6I41_RS12945	COG0456	acetyltransferase
I6I41_RS12955	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6I41_RS12965	COG2311	Membrane
I6I41_RS12970	COG2233	PERMEase
I6I41_RS12980	COG0024	Methionine aminopeptidase
I6I41_RS12990	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6I41_RS12995	COG1199	ATP-dependent helicase activity
I6I41_RS13015	COG0457	Tetratricopeptide repeat
I6I41_RS13035	COG0116	Belongs to the methyltransferase superfamily
I6I41_RS13090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I41_RS13090	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6I41_RS13100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I41_RS13105	COG3935	DnaD domain protein
I6I41_RS13125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I41_RS13125	COG1199	ATP-dependent helicase activity
I6I41_RS13160	COG0438	transferase activity, transferring glycosyl groups
I6I41_RS13180	COG1694	Mazg nucleotide pyrophosphohydrolase
I6I41_RS13185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I41_RS13195	COG2738	Putative neutral zinc metallopeptidase
I6I41_RS13210	COG4347	Protein of unknown function (DUF1405)
I6I41_RS13215	COG2010	Cytochrome c
I6I41_RS13215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6I41_RS13220	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6I41_RS13240	COG0457	Tetratricopeptide repeat
I6I41_RS13265	COG0142	geranyltranstransferase activity
I6I41_RS13275	COG0142	geranyltranstransferase activity
I6I41_RS13290	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6I41_RS13360	COG0252	asparaginase activity
I6I41_RS13365	COG0492	ferredoxin-NADP+ reductase activity
I6I41_RS13385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I41_RS13395	COG0789	Transcriptional regulator
I6I41_RS13400	COG1408	metallophosphoesterase
I6I41_RS13410	COG1266	CAAX protease self-immunity
I6I41_RS13415	COG0514	ATP-dependent DNA helicase (RecQ)
I6I41_RS13425	COG1141	Ferredoxin
I6I41_RS13430	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6I41_RS13445	COG2096	Adenosyltransferase
I6I41_RS13450	COG5002	protein histidine kinase activity
I6I41_RS13455	COG0745	RESPONSE REGULATOR receiver
I6I41_RS13460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I41_RS13465	COG1333	cytochrome c biogenesis protein
I6I41_RS13475	COG1187	pseudouridine synthase activity
I6I41_RS13480	COG0700	Nucleoside recognition
I6I41_RS13485	COG2715	membrane protein required for spore maturation
I6I41_RS13490	COG1686	Belongs to the peptidase S11 family
I6I41_RS13495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I41_RS13510	COG0392	lysyltransferase activity
I6I41_RS13510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6I41_RS13525	COG5002	protein histidine kinase activity
I6I41_RS13530	COG0582	viral genome integration into host DNA
I6I41_RS13540	COG1801	Protein of unknown function DUF72
I6I41_RS13545	COG3852	Histidine kinase
I6I41_RS13560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I41_RS13565	COG1392	Phosphate transport regulator
I6I41_RS13570	COG0306	phosphate transporter
I6I41_RS13575	COG0730	response to heat
I6I41_RS13625	COG1114	Component of the transport system for branched-chain amino acids
I6I41_RS13635	COG2197	response regulator
I6I41_RS13640	COG4585	Histidine kinase
I6I41_RS13645	COG4758	membrane
I6I41_RS13660	COG1757	Na H antiporter
I6I41_RS13685	COG0733	neurotransmitter:sodium symporter activity
I6I41_RS13690	COG1648	precorrin-2 dehydrogenase activity
I6I41_RS13710	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I41_RS13715	COG0529	Catalyzes the synthesis of activated sulfate
I6I41_RS13735	COG0019	diaminopimelate decarboxylase activity
I6I41_RS13745	COG1368	sulfuric ester hydrolase activity
I6I41_RS13750	COG1183	phosphatidylcholine synthase activity
I6I41_RS13765	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I41_RS13840	COG0440	acetolactate synthase activity
I6I41_RS13845	COG0028	Belongs to the TPP enzyme family
I6I41_RS13850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I41_RS13870	COG3874	Sporulation protein YtfJ
I6I41_RS13875	COG4709	membrane
I6I41_RS13880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I41_RS13885	COG1301	dicarboxylic acid transport
I6I41_RS13895	COG1846	Transcriptional regulator
I6I41_RS13950	COG0716	FMN binding
I6I41_RS13975	COG1696	Membrane protein involved in D-alanine export
I6I41_RS13985	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6I41_RS13990	COG2070	2-Nitropropane dioxygenase
I6I41_RS13995	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6I41_RS14005	COG1335	isochorismatase
I6I41_RS14015	COG1522	sequence-specific DNA binding
I6I41_RS14025	COG1266	CAAX protease self-immunity
I6I41_RS14030	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6I41_RS14035	COG1131	(ABC) transporter
I6I41_RS14045	COG1131	(ABC) transporter
I6I41_RS14050	COG1725	Transcriptional regulator
I6I41_RS14055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I41_RS14060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I41_RS14065	COG1780	Probably involved in ribonucleotide reductase function
I6I41_RS14095	COG4873	Protein conserved in bacteria
I6I41_RS14110	COG0720	synthase
I6I41_RS14120	COG5002	protein histidine kinase activity
I6I41_RS14125	COG2318	DinB family
I6I41_RS14135	COG1846	Transcriptional regulator
I6I41_RS14140	COG3852	Histidine kinase
I6I41_RS14150	COG2861	carbohydrate metabolic process
I6I41_RS14160	COG0235	Class ii aldolase
I6I41_RS14170	COG1349	DNA-binding transcription factor activity
I6I41_RS14195	COG3842	ATPase activity
I6I41_RS14200	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I41_RS14215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I41_RS14225	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6I41_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS14250	COG2030	dehydratase
I6I41_RS14260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I41_RS14265	COG0861	Integral membrane protein TerC family
I6I41_RS14270	COG2116	formate transmembrane transporter activity
I6I41_RS14280	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6I41_RS14300	COG2186	Transcriptional regulator
I6I41_RS14305	COG5002	protein histidine kinase activity
I6I41_RS14310	COG0745	RESPONSE REGULATOR receiver
I6I41_RS14320	COG3835	regulator
I6I41_RS14325	COG0277	FAD linked oxidase domain protein
I6I41_RS14330	COG0247	lactate metabolic process
I6I41_RS14335	COG2340	Cysteine-rich secretory protein family
I6I41_RS14345	COG0564	pseudouridine synthase activity
I6I41_RS14355	COG2409	Drug exporters of the RND superfamily
I6I41_RS14370	COG1177	transmembrane transport
I6I41_RS14375	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I41_RS14385	COG1012	belongs to the aldehyde dehydrogenase family
I6I41_RS14420	COG0681	Belongs to the peptidase S26 family
I6I41_RS14425	COG1686	Belongs to the peptidase S11 family
I6I41_RS14530	COG1476	TRANSCRIPTIONal
I6I41_RS14540	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I41_RS14590	COG5634	Uncharacterized conserved protein (DUF2278)
I6I41_RS14595	COG1620	l-lactate permease
I6I41_RS14630	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I41_RS14630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I41_RS14640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I41_RS14660	COG2382	esterase
I6I41_RS14670	COG2153	protein acetylation
I6I41_RS14715	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6I41_RS14730	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I41_RS14750	COG0457	Tetratricopeptide repeat
I6I41_RS14750	COG0463	Glycosyl transferase, family 2
I6I41_RS14770	COG1216	Glycosyl transferase, family 2
I6I41_RS14775	COG0772	Belongs to the SEDS family
I6I41_RS14790	COG0564	pseudouridine synthase activity
I6I41_RS14800	COG2357	RelA SpoT domain protein
I6I41_RS14810	COG4116	CYTH
I6I41_RS14815	COG2346	COG2346, Truncated hemoglobins
I6I41_RS14830	COG1164	Oligoendopeptidase f
I6I41_RS14850	COG0861	Integral membrane protein TerC family
I6I41_RS14865	COG4166	transmembrane transport
I6I41_RS14870	COG0534	Mate efflux family protein
I6I41_RS14875	COG4608	Belongs to the ABC transporter superfamily
I6I41_RS14880	COG0444	Belongs to the ABC transporter superfamily
I6I41_RS14885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I41_RS14890	COG0601	transmembrane transport
I6I41_RS14895	COG4166	transmembrane transport
I6I41_RS14905	COG0180	Tryptophanyl-tRNA synthetase
I6I41_RS14915	COG5504	Zn-dependent protease
I6I41_RS14920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I41_RS14940	COG2267	carboxylic ester hydrolase activity
I6I41_RS14960	COG0561	phosphatase activity
I6I41_RS14975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I41_RS14990	COG2996	Protein conserved in bacteria
I6I41_RS15010	COG0004	ammonium transporteR
I6I41_RS15015	COG0753	catalase activity
I6I41_RS15025	COG0367	asparagine synthase
I6I41_RS15050	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I41_RS15110	COG0398	Pfam SNARE associated Golgi protein
I6I41_RS15130	COG1278	Cold shock
I6I41_RS15145	COG2224	Isocitrate lyase
I6I41_RS15150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I41_RS15160	COG3693	PFAM glycoside hydrolase, family 10
I6I41_RS15165	COG0840	transmembrane signaling receptor activity
I6I41_RS15170	COG0501	Belongs to the peptidase M48B family
I6I41_RS15190	COG0745	RESPONSE REGULATOR receiver
I6I41_RS15195	COG2205	protein histidine kinase activity
I6I41_RS15205	COG3708	Transcriptional regulator
I6I41_RS15205	COG2207	Transcriptional regulator
I6I41_RS15210	COG1595	DNA-templated transcription, initiation
I6I41_RS15220	COG1078	dGTPase activity
I6I41_RS15225	COG1408	metallophosphoesterase
I6I41_RS15310	COG4208	sulfate ABC transporter
I6I41_RS15320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I41_RS15330	COG0318	PFAM AMP-dependent synthetase and ligase
I6I41_RS15340	COG0095	Lipoate-protein ligase
I6I41_RS15345	COG1234	tRNA 3'-trailer cleavage
I6I41_RS15355	COG1609	Transcriptional regulator
I6I41_RS15360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS15385	COG1511	domain protein
I6I41_RS15390	COG1309	transcriptional regulator
I6I41_RS15425	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6I41_RS15440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I41_RS15445	COG2329	Antibiotic biosynthesis monooxygenase
I6I41_RS15450	COG3428	Bacterial PH domain
I6I41_RS15455	COG3402	PFAM membrane-flanked domain
I6I41_RS15460	COG0697	spore germination
I6I41_RS15495	COG3428	Bacterial PH domain
I6I41_RS15500	COG3402	PFAM membrane-flanked domain
I6I41_RS15525	COG4473	ABC transporter
I6I41_RS15530	COG1131	(ABC) transporter
I6I41_RS15535	COG0537	adenosine 5'-monophosphoramidase activity
I6I41_RS15540	COG4980	gas vesicle protein
I6I41_RS15570	COG3973	AAA domain
I6I41_RS15585	COG1595	DNA-templated transcription, initiation
I6I41_RS15600	COG1695	Transcriptional regulator
I6I41_RS15605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I41_RS15615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I41_RS15620	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6I41_RS15625	COG3620	sequence-specific DNA binding
I6I41_RS15630	COG2140	Oxalate decarboxylase
I6I41_RS15655	COG2267	carboxylic ester hydrolase activity
I6I41_RS15665	COG0457	Tetratricopeptide repeat
I6I41_RS15670	COG0346	lactoylglutathione lyase activity
I6I41_RS15675	COG0346	lactoylglutathione lyase activity
I6I41_RS15690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I41_RS15700	COG4717	serine-type aminopeptidase activity
I6I41_RS15705	COG0420	3'-5' exonuclease activity
I6I41_RS15725	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6I41_RS15770	COG5002	protein histidine kinase activity
I6I41_RS15770	COG2205	protein histidine kinase activity
I6I41_RS15770	COG0784	Response regulator, receiver
I6I41_RS15775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I41_RS15780	COG2208	phosphoserine phosphatase activity
I6I41_RS15790	COG1191	sigma factor activity
I6I41_RS15875	COG2373	Large extracellular alpha-helical protein
I6I41_RS15880	COG0791	NLP P60 protein
I6I41_RS15880	COG1388	LysM domain
I6I41_RS15885	COG3584	3D domain protein
I6I41_RS15885	COG1388	LysM domain
I6I41_RS15920	COG2376	Dihydroxyacetone kinase
I6I41_RS15930	COG2376	Dihydroxyacetone kinase
I6I41_RS15945	COG1183	phosphatidylcholine synthase activity
I6I41_RS15985	COG1073	alpha beta
I6I41_RS16010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS16025	COG0477	Major facilitator Superfamily
I6I41_RS16060	COG0305	Participates in initiation and elongation during chromosome replication
I6I41_RS16095	COG0789	Transcriptional regulator
I6I41_RS16095	COG4978	Transcriptional regulator
I6I41_RS16120	COG3421	Type III restriction
I6I41_RS16125	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6I41_RS16130	COG0210	DNA helicase
I6I41_RS16155	COG3181	Tripartite tricarboxylate transporter family receptor
I6I41_RS16160	COG4565	transcriptional regulatory protein
I6I41_RS16165	COG3290	protein histidine kinase activity
I6I41_RS16170	COG0477	Major facilitator Superfamily
I6I41_RS16220	COG0577	efflux transmembrane transporter activity
I6I41_RS16220	COG1136	(ABC) transporter
I6I41_RS16235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS16245	COG4608	Belongs to the ABC transporter superfamily
I6I41_RS16250	COG0444	Belongs to the ABC transporter superfamily
I6I41_RS16255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I41_RS16260	COG0601	transmembrane transport
I6I41_RS16295	COG1363	Peptidase, m42
I6I41_RS16315	COG1024	Enoyl-CoA hydratase
I6I41_RS16335	COG2244	polysaccharide biosynthetic process
I6I41_RS16340	COG0659	secondary active sulfate transmembrane transporter activity
I6I41_RS16355	COG0318	PFAM AMP-dependent synthetase and ligase
I6I41_RS16360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I41_RS16365	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6I41_RS16365	COG3409	Peptidoglycan-binding domain 1 protein
I6I41_RS16375	COG0561	phosphatase activity
I6I41_RS16385	COG3527	Alpha-acetolactate decarboxylase
I6I41_RS16390	COG0028	Belongs to the TPP enzyme family
I6I41_RS16425	COG0189	ligase activity
I6I41_RS16440	COG1126	abc transporter atp-binding protein
I6I41_RS16445	COG0765	amino acid transport
I6I41_RS16450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I41_RS16455	COG1132	(ABC) transporter
I6I41_RS16460	COG1132	(ABC) transporter
I6I41_RS16465	COG1012	belongs to the aldehyde dehydrogenase family
I6I41_RS16475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I41_RS16480	COG0531	amino acid
I6I41_RS16490	COG0693	protein deglycase activity
I6I41_RS16490	COG0753	catalase activity
I6I41_RS16495	COG0693	protein deglycase activity
I6I41_RS16510	COG2211	Major facilitator Superfamily
I6I41_RS16515	COG4533	DNA binding
I6I41_RS16535	COG1733	regulation of RNA biosynthetic process
I6I41_RS16540	COG2814	Major facilitator Superfamily
I6I41_RS16545	COG1309	transcriptional regulator
I6I41_RS16565	COG0300	oxidoreductase activity
I6I41_RS16570	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I41_RS16570	COG0165	Argininosuccinate lyase
I6I41_RS16575	COG1522	sequence-specific DNA binding
I6I41_RS16595	COG2259	Doxx family
I6I41_RS16605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I41_RS16605	COG1263	PTS System
I6I41_RS16615	COG1737	Transcriptional regulator
I6I41_RS16625	COG0475	glutathione-regulated potassium exporter activity
I6I41_RS16630	COG0531	amino acid
I6I41_RS16665	COG0586	Pfam SNARE associated Golgi protein
I6I41_RS16700	COG3546	catalase activity
I6I41_RS16705	COG1114	Component of the transport system for branched-chain amino acids
I6I41_RS16720	COG5522	Integral membrane protein (intg_mem_TP0381)
I6I41_RS16730	COG1136	(ABC) transporter
I6I41_RS16735	COG0577	efflux transmembrane transporter activity
I6I41_RS16740	COG3584	3D domain protein
I6I41_RS16740	COG1388	LysM domain
I6I41_RS16765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I41_RS16770	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I41_RS16775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I41_RS16775	COG3711	transcriptional antiterminator
I6I41_RS16790	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I41_RS16795	COG0604	alcohol dehydrogenase
I6I41_RS16800	COG1316	TRANSCRIPTIONal
I6I41_RS16810	COG0730	response to heat
I6I41_RS16815	COG2210	Belongs to the sulfur carrier protein TusA family
I6I41_RS16825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I41_RS16825	COG0425	Belongs to the sulfur carrier protein TusA family
I6I41_RS16830	COG0425	Belongs to the sulfur carrier protein TusA family
I6I41_RS16835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I41_RS16835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS16840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I41_RS16840	COG0425	Belongs to the sulfur carrier protein TusA family
I6I41_RS16845	COG1937	Protein conserved in bacteria
I6I41_RS16850	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I41_RS16875	COG2719	SpoVR family
I6I41_RS16880	COG0778	Nitroreductase
I6I41_RS16930	COG1609	Transcriptional regulator
I6I41_RS16935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I41_RS16935	COG1263	PTS System
I6I41_RS16940	COG1621	beta-fructofuranosidase activity
I6I41_RS16945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I41_RS16960	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS16965	COG2252	PERMEase
I6I41_RS16975	COG1846	Transcriptional regulator
I6I41_RS16980	COG2814	Major facilitator Superfamily
I6I41_RS16985	COG2205	protein histidine kinase activity
I6I41_RS17025	COG0351	phosphomethylpyrimidine kinase
I6I41_RS17030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I41_RS17040	COG2104	thiamine diphosphate biosynthetic process
I6I41_RS17045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I41_RS17050	COG0352	thiamine-phosphate diphosphorylase activity
I6I41_RS17055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I41_RS17060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I41_RS17065	COG1116	anion transmembrane transporter activity
I6I41_RS17070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I41_RS17090	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6I41_RS17210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I41_RS17215	COG0581	inorganic phosphate transmembrane transporter activity
I6I41_RS17220	COG0573	inorganic phosphate transmembrane transporter activity
I6I41_RS17225	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I41_RS17230	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I41_RS17230	COG1918	ferrous iron import across plasma membrane
I6I41_RS17235	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I41_RS17240	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I41_RS17255	COG0531	amino acid
I6I41_RS17260	COG0697	spore germination
I6I41_RS17265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I41_RS17280	COG4990	cell redox homeostasis
I6I41_RS17285	COG0833	amino acid
I6I41_RS17295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I41_RS17300	COG1845	cytochrome c oxidase, subunit III
I6I41_RS17310	COG0475	glutathione-regulated potassium exporter activity
I6I41_RS17310	COG0569	domain protein
I6I41_RS17320	COG2153	protein acetylation
I6I41_RS17335	COG2252	PERMEase
I6I41_RS17340	COG1113	amino acid transport
I6I41_RS17355	COG1114	Component of the transport system for branched-chain amino acids
I6I41_RS17360	COG3104	oligopeptide transport
I6I41_RS17380	COG1476	TRANSCRIPTIONal
I6I41_RS17385	COG3584	3D domain protein
I6I41_RS17385	COG3583	domain protein
I6I41_RS17390	COG0840	transmembrane signaling receptor activity
I6I41_RS17440	COG1063	alcohol dehydrogenase
I6I41_RS17465	COG1879	ABC-type sugar transport system periplasmic component
I6I41_RS17470	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I41_RS17485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I41_RS17490	COG1609	Transcriptional regulator
I6I41_RS17495	COG0477	Major facilitator Superfamily
I6I41_RS17500	COG1846	Transcriptional regulator
I6I41_RS17505	COG2271	Major facilitator Superfamily
I6I41_RS17520	COG0659	secondary active sulfate transmembrane transporter activity
I6I41_RS17535	COG5002	protein histidine kinase activity
I6I41_RS17540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6I41_RS17545	COG2378	regulation of single-species biofilm formation
I6I41_RS17560	COG0833	amino acid
I6I41_RS17565	COG0765	amino acid transport
I6I41_RS17570	COG0765	amino acid transport
I6I41_RS17575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I41_RS17580	COG1126	abc transporter atp-binding protein
I6I41_RS17585	COG1115	amino acid carrier protein
I6I41_RS17590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I41_RS17595	COG0697	spore germination
I6I41_RS17610	COG0366	Alpha amylase catalytic
I6I41_RS17615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I41_RS17615	COG1263	PTS System
I6I41_RS17620	COG2188	Transcriptional regulator
I6I41_RS17625	COG0531	amino acid
I6I41_RS17645	COG0714	Associated with various cellular activities
I6I41_RS17650	COG4548	von Willebrand factor, type A
I6I41_RS17660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I41_RS17670	COG2226	methyltransferase
I6I41_RS17680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I41_RS17685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I41_RS17690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I41_RS17695	COG3104	oligopeptide transport
I6I41_RS17710	COG1620	l-lactate permease
I6I41_RS17715	COG1027	Aspartate ammonia-lyase
I6I41_RS17720	COG1253	flavin adenine dinucleotide binding
I6I41_RS17725	COG0346	lactoylglutathione lyase activity
I6I41_RS17730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I41_RS17735	COG1316	TRANSCRIPTIONal
I6I41_RS17740	COG2720	vancomycin resistance protein
I6I41_RS17760	COG3227	Zinc metalloprotease (Elastase)
I6I41_RS17775	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I41_RS17780	COG2217	Heavy metal translocating P-type atpase
I6I41_RS17785	COG0640	Transcriptional regulator
I6I41_RS17795	COG0531	amino acid
I6I41_RS17810	COG2427	Protein of unknown function (DUF1641)
I6I41_RS17815	COG3383	formate dehydrogenase (NAD+) activity
I6I41_RS17820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I41_RS17825	COG0454	-acetyltransferase
I6I41_RS17825	COG0456	acetyltransferase
I6I41_RS17835	COG5002	protein histidine kinase activity
I6I41_RS17845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I41_RS17850	COG0697	spore germination
I6I41_RS17860	COG0281	malic enzyme
I6I41_RS17865	COG3493	citrate carrier protein
I6I41_RS17870	COG4565	transcriptional regulatory protein
I6I41_RS17875	COG3290	protein histidine kinase activity
I6I41_RS17885	COG4990	cell redox homeostasis
I6I41_RS17895	COG3850	Histidine kinase
I6I41_RS17895	COG5002	protein histidine kinase activity
I6I41_RS17900	COG0745	RESPONSE REGULATOR receiver
I6I41_RS17905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I41_RS17915	COG0395	ABC-type sugar transport system, permease component
I6I41_RS17920	COG1175	transmembrane transport
I6I41_RS17925	COG3842	ATPase activity
I6I41_RS17930	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6I41_RS17955	COG2851	Citrate transporter
I6I41_RS17960	COG4565	transcriptional regulatory protein
I6I41_RS17965	COG3290	protein histidine kinase activity
I6I41_RS17975	COG2268	Band 7 protein
I6I41_RS17980	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I41_RS17990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I41_RS18020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I41_RS18025	COG0577	efflux transmembrane transporter activity
I6I41_RS18030	COG1136	(ABC) transporter
I6I41_RS18045	COG2205	protein histidine kinase activity
I6I41_RS18080	COG2814	Major facilitator Superfamily
I6I41_RS18090	COG2766	serine protein kinase
I6I41_RS18095	COG5001	Diguanylate cyclase
I6I41_RS18095	COG1716	ATPase activity
I6I41_RS18100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I41_RS18125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I41_RS18245	COG0735	belongs to the Fur family
I6I41_RS18250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I41_RS18270	COG4555	ABC transporter
I6I41_RS18280	COG0069	glutamate synthase activity
I6I41_RS18280	COG0070	glutamate synthase
I6I41_RS18280	COG0067	glutamate synthase
I6I41_RS18285	COG4129	membrane
I6I41_RS18290	COG1132	(ABC) transporter
I6I41_RS18315	COG1194	a g-specific adenine glycosylase
I6I41_RS18320	COG1988	membrane-bound metal-dependent
I6I41_RS18350	COG1090	epimerase
I6I41_RS18355	COG1228	amidohydrolase
I6I41_RS18375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I41_RS18395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I41_RS18395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I41_RS18405	COG0463	Glycosyl transferase, family 2
I6I41_RS18420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I41_RS18425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I41_RS18425	COG1263	PTS System
I6I41_RS18455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I41_RS18460	COG0833	amino acid
I6I41_RS18470	COG3829	transcription factor binding
I6I41_RS18485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I41_RS18490	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6I41_RS18510	COG0535	radical SAM domain protein
I6I41_RS18520	COG0387	Pfam Sodium calcium exchanger
I6I41_RS18525	COG3871	stress protein (general stress protein 26)
I6I41_RS18540	COG0586	Pfam SNARE associated Golgi protein
I6I41_RS18550	COG0681	Belongs to the peptidase S26 family
I6I41_RS18560	COG0697	spore germination
I6I41_RS18565	COG2217	Heavy metal translocating P-type atpase
I6I41_RS18570	COG1295	ribonuclease BN
I6I41_RS18580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I41_RS18595	COG3853	Toxic anion resistance protein (TelA)
I6I41_RS18605	COG0861	Integral membrane protein TerC family
I6I41_RS18610	COG2310	stress, protein
I6I41_RS18615	COG2310	stress, protein
I6I41_RS18620	COG2310	stress, protein
I6I41_RS18650	COG2270	Major facilitator Superfamily
I6I41_RS18700	COG1116	anion transmembrane transporter activity
I6I41_RS18705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I41_RS18710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I41_RS18730	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I41_RS18760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I41_RS18760	COG1263	PTS System
I6I41_RS18760	COG2190	(PTS) system
I6I41_RS18765	COG0366	Alpha amylase catalytic
I6I41_RS18770	COG0277	FAD linked oxidase domain protein
I6I41_RS18780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I41_RS18785	COG0549	Belongs to the carbamate kinase family
I6I41_RS18810	COG0840	transmembrane signaling receptor activity
I6I41_RS18820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I41_RS18825	COG0765	amino acid transport
I6I41_RS18835	COG0723	plastoquinol--plastocyanin reductase activity
I6I41_RS18835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I41_RS18840	COG2814	Major facilitator Superfamily
I6I41_RS18845	COG3541	Predicted nucleotidyltransferase
I6I41_RS18865	COG5002	protein histidine kinase activity
I6I41_RS18890	COG0166	Belongs to the GPI family
I6I41_RS18900	COG0492	ferredoxin-NADP+ reductase activity
I6I41_RS18905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I41_RS18910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I41_RS18915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I41_RS18935	COG0450	alkyl hydroperoxide reductase
I6I41_RS18950	COG1473	amidohydrolase
I6I41_RS18955	COG1757	Na H antiporter
I6I41_RS18980	COG4807	Protein conserved in bacteria
I6I41_RS18985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I41_RS18995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I41_RS19015	COG2309	aminopeptidase activity
I6I41_RS19025	COG2076	Multidrug Resistance protein
I6I41_RS19030	COG1012	belongs to the aldehyde dehydrogenase family
I6I41_RS19040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I41_RS19050	COG1597	lipid kinase activity
I6I41_RS19070	COG4682	membrane
I6I41_RS19075	COG1846	Transcriptional regulator
I6I41_RS19080	COG0003	Pfam Anion-transporting ATPase
I6I41_RS19095	COG1464	Belongs to the NlpA lipoprotein family
I6I41_RS19100	COG2011	ABC-type metal ion transport system permease component
I6I41_RS19110	COG1335	isochorismatase
I6I41_RS19125	COG4851	CamS sex pheromone cAM373 precursor
I6I41_RS19135	COG0210	DNA helicase
I6I41_RS19160	COG0151	Belongs to the GarS family
I6I41_RS19170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I41_RS19180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I41_RS19195	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I41_RS19205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I41_RS19210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I41_RS19215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I41_RS19240	COG0697	spore germination
I6I41_RS19260	COG1215	transferase activity, transferring glycosyl groups
I6I41_RS19270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I41_RS19280	COG2226	methyltransferase
I6I41_RS19310	COG0745	RESPONSE REGULATOR receiver
I6I41_RS19315	COG2205	protein histidine kinase activity
I6I41_RS19425	COG2183	response to ionizing radiation
I6I41_RS19430	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6I41_RS19435	COG0864	Transcriptional regulator
I6I41_RS19440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I41_RS19445	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I41_RS19455	COG0705	Rhomboid family
I6I41_RS19460	COG4294	response to UV
I6I41_RS19470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I41_RS19480	COG2814	Major facilitator Superfamily
I6I41_RS19485	COG0531	amino acid
I6I41_RS19495	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I41_RS19500	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6I41_RS19530	COG0561	phosphatase activity
I6I41_RS19535	COG4608	Belongs to the ABC transporter superfamily
I6I41_RS19540	COG0444	Belongs to the ABC transporter superfamily
I6I41_RS19545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I41_RS19550	COG0601	transmembrane transport
I6I41_RS19555	COG0747	negative chemotaxis
I6I41_RS19565	COG0488	(ABC) transporter
I6I41_RS19585	COG5298	Protein conserved in bacteria
I6I41_RS19600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I41_RS19610	COG1609	Transcriptional regulator
I6I41_RS19620	COG0204	Acyl-transferase
I6I41_RS19635	COG0697	spore germination
I6I41_RS19650	COG1910	domain protein
I6I41_RS19655	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I41_RS19660	COG4149	molybdate abc transporter
I6I41_RS19675	COG0656	L-ascorbic acid biosynthetic process
I6I41_RS19680	COG4166	transmembrane transport
I6I41_RS19685	COG4166	transmembrane transport
I6I41_RS19700	COG2207	Transcriptional regulator
I6I41_RS19710	COG4166	transmembrane transport
I6I41_RS19715	COG4608	Belongs to the ABC transporter superfamily
I6I41_RS19720	COG0444	Belongs to the ABC transporter superfamily
I6I41_RS19725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I41_RS19730	COG0601	transmembrane transport
I6I41_RS19745	COG2814	Major facilitator Superfamily
I6I41_RS19755	COG2271	Major facilitator Superfamily
I6I41_RS19760	COG0277	FAD linked oxidase domain protein
I6I41_RS19770	COG0604	alcohol dehydrogenase
I6I41_RS19775	COG1464	Belongs to the NlpA lipoprotein family
I6I41_RS19780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I41_RS19785	COG2011	ABC-type metal ion transport system permease component
I6I41_RS19790	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS19840	COG4856	YbbR-like protein
I6I41_RS19845	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6I41_RS19925	COG0726	polysaccharide deacetylase
I6I41_RS19930	COG2194	sulfuric ester hydrolase activity
I6I41_RS19940	COG0489	protein tyrosine kinase activity
I6I41_RS19945	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I41_RS19970	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I41_RS20005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I41_RS20015	COG0024	Methionine aminopeptidase
I6I41_RS20025	COG0201	protein transport
I6I41_RS20085	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I41_RS20150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I41_RS20155	COG1358	cellular component organization or biogenesis
I6I41_RS20170	COG2813	Specifically methylates the guanine in position
I6I41_RS20190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I41_RS20195	COG0250	Participates in transcription elongation, termination and antitermination
I6I41_RS20200	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I41_RS20215	COG3688	RNA-binding protein containing a PIN domain
I6I41_RS20220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I41_RS20235	COG1045	serine acetyltransferase
I6I41_RS20255	COG4956	integral membrane protein (PIN domain superfamily)
I6I41_RS20265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6I41_RS20270	COG0542	response to heat
I6I41_RS20280	COG3880	PFAM UvrB UvrC protein
I6I41_RS20370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I41_RS20375	COG1396	sequence-specific DNA binding
I6I41_RS20380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I41_RS20385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I41_RS20390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I41_RS20395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I41_RS20400	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I41_RS20405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I41_RS20410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I41_RS20425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I41_RS20430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6I41_RS20440	COG2208	phosphoserine phosphatase activity
I6I41_RS20455	COG1098	S1 RNA binding domain
I6I41_RS20475	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I41_RS20480	COG3956	TIGRFAM MazG family protein
I6I41_RS20485	COG2244	polysaccharide biosynthetic process
I6I41_RS20490	COG2002	toxin-antitoxin pair type II binding
I6I41_RS20495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I41_RS20525	COG0251	oxidation-reduction process
I6I41_RS20530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I41_RS20545	COG4466	Protein conserved in bacteria
I6I41_RS20565	COG0084	hydrolase, TatD family'
I6I41_RS20575	COG2002	toxin-antitoxin pair type II binding
I6I41_RS20580	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I41_RS20590	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I41_RS20600	COG1774	PSP1 C-terminal conserved region
I6I41_RS20605	COG0470	DNA polymerase III
I6I41_RS20615	COG1982	Orn Lys Arg decarboxylase major
I6I41_RS20670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I41_RS20680	COG0590	tRNA wobble adenosine to inosine editing
I6I41_RS20685	COG1335	isochorismatase
I6I41_RS20690	COG1428	Deoxynucleoside kinase
I6I41_RS20695	COG1428	Deoxynucleoside kinase
I6I41_RS20725	COG1686	Belongs to the peptidase S11 family
I6I41_RS20730	COG0517	IMP dehydrogenase activity
I6I41_RS20730	COG0516	GMP reductase activity
I6I41_RS20765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I41_RS20770	COG0187	DNA topoisomerase II activity
I6I41_RS20780	COG2501	S4 domain
I6I41_RS20785	COG0592	DNA-directed DNA polymerase activity
I6I41_RS20795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I41_RS20810	COG1847	R3H domain protein
I6I41_RS20835	COG1192	Involved in chromosome partitioning
I6I41_RS20840	COG1475	DNA binding
I6I41_RS20850	COG0668	transmembrane transport
I6I41_RS20855	COG4481	Protein conserved in bacteria
I6I41_RS20860	COG0012	GTP binding
I6I41_RS20885	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6I41_RS20895	COG0305	Participates in initiation and elongation during chromosome replication
I6I41_RS20925	COG0745	RESPONSE REGULATOR receiver
I6I41_RS20930	COG5002	protein histidine kinase activity
I6I41_RS20940	COG4853	Protein conserved in bacteria
I6I41_RS20945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I41_RS20950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I41_RS20965	COG5002	protein histidine kinase activity
I6I41_RS20975	COG1164	Oligoendopeptidase f
I6I41_RS20995	COG1272	protein, Hemolysin III
I6I41_RS21000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I41_RS21020	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I6I41_RS21025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I41_RS21030	COG2814	Major facilitator Superfamily
I6I41_RS21035	COG3275	phosphorelay sensor kinase activity
I6I41_RS21055	COG0628	permease
I6I41_RS21060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I41_RS21060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I41_RS21065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I41_RS21070	COG1309	transcriptional regulator
I6I41_RS21075	COG0488	(ABC) transporter
I6I41_RS21080	COG0463	Glycosyl transferase, family 2
I6I41_RS21085	COG4485	Bacterial membrane protein, YfhO
I6I41_RS21095	COG1216	Glycosyl transferase, family 2
I6I41_RS21105	COG1216	Glycosyl transferase, family 2
I6I41_RS21110	COG1607	acyl-coa hydrolase
I6I41_RS21120	COG0840	transmembrane signaling receptor activity
I6I41_RS21135	COG0438	transferase activity, transferring glycosyl groups
I6I41_RS21140	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6I41_RS21145	COG0477	Major facilitator Superfamily
I6I41_RS21150	COG3279	Response regulator of the LytR AlgR family
I6I41_RS21155	COG1966	Carbon starvation protein
I6I41_RS21160	COG2879	small protein
I6I41_RS21165	COG3706	GGDEF domain
I6I41_RS21170	COG0351	phosphomethylpyrimidine kinase
I6I41_RS21175	COG2203	Gaf domain
I6I41_RS21175	COG4585	Histidine kinase
I6I41_RS21180	COG2197	response regulator
I6I41_RS21190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I41_RS21195	COG1011	Hydrolase
I6I41_RS21205	COG2873	o-acetylhomoserine
I6I41_RS21215	COG0460	homoserine dehydrogenase
I6I41_RS21225	COG1609	Transcriptional regulator
I6I41_RS21230	COG2755	lipolytic protein G-D-S-L family
I6I41_RS21235	COG1131	(ABC) transporter
I6I41_RS21240	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6I41_RS21250	COG2814	Major facilitator Superfamily
I6I41_RS21255	COG0561	phosphatase activity
I6I41_RS21260	COG2233	PERMEase
I6I41_RS21265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I41_RS21275	COG2363	Small membrane protein
I6I41_RS21285	COG3773	Cell wall hydrolase
I6I41_RS21300	COG0280	phosphate acetyltransferase
I6I41_RS21320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I41_RS21325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I41_RS21330	COG1120	ATPase activity
I6I41_RS21335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I41_RS21340	COG1078	dGTPase activity
I6I41_RS21350	COG1994	Peptidase M50
I6I41_RS21360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I41_RS21365	COG0584	glycerophosphoryl diester phosphodiesterase
I6I41_RS21370	COG0789	Transcriptional regulator
I6I41_RS21375	COG2814	Major facilitator Superfamily
I6I41_RS21400	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6I41_RS21405	COG4506	Protein conserved in bacteria
I6I41_RS21415	COG1595	DNA-templated transcription, initiation
I6I41_RS21430	COG2234	aminopeptidase activity
I6I41_RS21440	COG0024	Methionine aminopeptidase
I6I41_RS21445	COG1131	(ABC) transporter
I6I41_RS21450	COG0842	Transport permease protein
I6I41_RS21455	COG4585	Histidine kinase
I6I41_RS21460	COG2197	response regulator
I6I41_RS21465	COG3227	Zinc metalloprotease (Elastase)
I6I41_RS21480	COG5001	Diguanylate cyclase
I6I41_RS21480	COG3300	MHYT domain
I6I41_RS21490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I41_RS21495	COG2181	nitrate reductase activity
I6I41_RS21495	COG0247	lactate metabolic process
I6I41_RS21500	COG0183	Belongs to the thiolase family
I6I41_RS21505	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I41_RS21510	COG1960	acyl-CoA dehydrogenase activity
I6I41_RS21515	COG1960	acyl-CoA dehydrogenase activity
I6I41_RS21525	COG3343	RNA polymerase activity
I6I41_RS21535	COG4821	SIS domain
I6I41_RS21555	COG1494	fructose-1,6-bisphosphatase
I6I41_RS21560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I41_RS21595	COG0009	L-threonylcarbamoyladenylate synthase
I6I41_RS21610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I41_RS21615	COG2259	Doxx family
I6I41_RS21630	COG0698	ribose 5-phosphate isomerase
I6I41_RS21665	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I41_RS21715	COG5001	Diguanylate cyclase
I6I41_RS21715	COG3300	MHYT domain
I6I41_RS21730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I41_RS21750	COG0839	Belongs to the complex I subunit 6 family
I6I41_RS21760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I41_RS21765	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I41_RS21770	COG1007	ATP synthesis coupled electron transport
I6I41_RS21775	COG4836	Membrane
I6I41_RS21790	COG2385	sporulation resulting in formation of a cellular spore
I6I41_RS21795	COG3279	Response regulator of the LytR AlgR family
I6I41_RS21810	COG0739	heme binding
I6I41_RS21820	COG1609	Transcriptional regulator
I6I41_RS21835	COG0489	protein tyrosine kinase activity
I6I41_RS21840	COG3944	biosynthesis protein
I6I41_RS21845	COG0489	protein tyrosine kinase activity
I6I41_RS21850	COG4464	protein tyrosine phosphatase activity
I6I41_RS21855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I41_RS21860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I41_RS21865	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I41_RS21870	COG2244	polysaccharide biosynthetic process
I6I41_RS21895	COG1316	TRANSCRIPTIONal
I6I41_RS21905	COG0745	RESPONSE REGULATOR receiver
I6I41_RS21910	COG5002	protein histidine kinase activity
I6I41_RS21925	COG2271	Major facilitator Superfamily
I6I41_RS21945	COG1136	(ABC) transporter
I6I41_RS21950	COG0577	efflux transmembrane transporter activity
I6I41_RS21990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I41_RS21995	COG4715	Zinc finger, swim domain protein
I6I41_RS22020	COG3584	3D domain protein
I6I41_RS22020	COG1388	LysM domain
I6I41_RS22025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I41_RS22030	COG1215	transferase activity, transferring glycosyl groups
I6I41_RS22040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I41_RS22045	COG1388	LysM domain
I6I41_RS22045	COG0791	NLP P60 protein
I6I41_RS22055	COG1368	sulfuric ester hydrolase activity
I6I41_RS22065	COG2389	metal-binding protein
I6I41_RS22075	COG1620	l-lactate permease
I6I41_RS22105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I41_RS22110	COG1294	oxidase, subunit
I6I41_RS22115	COG1271	oxidase subunit
I6I41_RS22125	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6I41_RS22130	COG0583	DNA-binding transcription factor activity
I6I41_RS22135	COG1511	domain protein
I6I41_RS22150	COG1301	dicarboxylic acid transport
I6I41_RS22155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I41_RS22165	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I41_RS22185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I41_RS22190	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I41_RS22195	COG1486	melibiose metabolic process
I6I41_RS22215	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6I41_RS22215	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6I41_RS22225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I41_RS22230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6I41_RS22235	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I41_RS22240	COG1316	TRANSCRIPTIONal
I6I41_RS22245	COG1739	Uncharacterized protein family UPF0029
I6I41_RS22250	COG1307	EDD domain protein, DegV family
I6I41_RS22255	COG1733	regulation of RNA biosynthetic process
I6I41_RS22260	COG1388	LysM domain
I6I41_RS22260	COG0791	NLP P60 protein
I6I41_RS22265	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6I41_RS22270	COG1040	competence protein
I6I41_RS22275	COG1278	Cold shock
I6I41_RS22280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I41_RS22300	COG2884	Cell division ATP-binding protein ftsE
I6I41_RS22305	COG2177	Part of the ABC transporter FtsEX involved in
I6I41_RS22310	COG0793	Belongs to the peptidase S41A family
I6I41_RS22310	COG3409	Peptidoglycan-binding domain 1 protein
I6I41_RS22315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I41_RS22320	COG1132	(ABC) transporter
I6I41_RS22330	COG0488	(ABC) transporter
I6I41_RS22335	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I41_RS22345	COG0583	DNA-binding transcription factor activity
I6I41_RS22365	COG0789	Transcriptional regulator
I6I41_RS22380	COG0556	nucleotide-excision repair
I6I41_RS22385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I41_RS22395	COG1950	PFAM Membrane protein of
I6I41_RS22415	COG0110	maltose O-acetyltransferase activity
I6I41_RS22420	COG0457	Tetratricopeptide repeat
I6I41_RS22425	COG0492	ferredoxin-NADP+ reductase activity
I6I41_RS22435	COG1051	belongs to the nudix hydrolase family
I6I41_RS22445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6I41_RS22455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I41_RS22465	COG2323	membrane
I6I41_RS22480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I41_RS22510	COG4585	Histidine kinase
I6I41_RS22515	COG4152	abc transporter atp-binding protein
I6I41_RS22520	COG1668	transmembrane transport
I6I41_RS22525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I41_RS22540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I41_RS22575	COG1346	cytolysis
I6I41_RS22580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I41_RS22585	COG1647	Serine aminopeptidase, S33
I6I41_RS22590	COG0557	exoribonuclease II activity
I6I41_RS22635	COG2233	PERMEase
I6I41_RS22640	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6I41_RS22645	COG0288	reversible hydration of carbon dioxide
I6I41_RS22650	COG1522	sequence-specific DNA binding
I6I41_RS22670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS22675	COG0488	(ABC) transporter
I6I41_RS22730	COG1252	NADH dehydrogenase
I6I41_RS22740	COG1733	regulation of RNA biosynthetic process
I6I41_RS22745	COG2814	Major facilitator Superfamily
I6I41_RS22750	COG0656	L-ascorbic acid biosynthetic process
I6I41_RS22765	COG2910	NAD(P)H-binding
I6I41_RS22770	COG1115	amino acid carrier protein
I6I41_RS22775	COG1115	amino acid carrier protein
I6I41_RS22780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I41_RS22785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I41_RS22790	COG2311	Membrane
I6I41_RS22795	COG1528	Iron-storage protein
I6I41_RS22805	COG1611	Belongs to the LOG family
I6I41_RS22825	COG0783	Belongs to the Dps family
I6I41_RS22830	COG1115	amino acid carrier protein
I6I41_RS22835	COG0490	domain, Protein
I6I41_RS22840	COG0475	glutathione-regulated potassium exporter activity
I6I41_RS22845	COG0586	Pfam SNARE associated Golgi protein
I6I41_RS22860	COG1741	Belongs to the pirin family
I6I41_RS22865	COG3227	Zinc metalloprotease (Elastase)
I6I41_RS22870	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I41_RS22875	COG0840	transmembrane signaling receptor activity
I6I41_RS22905	COG5002	protein histidine kinase activity
I6I41_RS22910	COG0745	RESPONSE REGULATOR receiver
I6I41_RS22915	COG1376	ErfK ybiS ycfS ynhG family protein
I6I41_RS22925	COG0586	Pfam SNARE associated Golgi protein
I6I41_RS22960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I41_RS22980	COG0531	amino acid
I6I41_RS22985	COG2814	Major facilitator Superfamily
I6I41_RS23000	COG0840	transmembrane signaling receptor activity
I6I41_RS23005	COG0011	TIGRFAM Protein of
I6I41_RS23020	COG1686	Belongs to the peptidase S11 family
I6I41_RS23030	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I41_RS23030	COG1024	Enoyl-CoA hydratase
I6I41_RS23035	COG0183	Belongs to the thiolase family
I6I41_RS23040	COG1960	acyl-CoA dehydrogenase activity
I6I41_RS23045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS23050	COG1309	transcriptional regulator
I6I41_RS23090	COG1393	Belongs to the ArsC family
I6I41_RS23100	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6I41_RS23105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I41_RS23120	COG2011	ABC-type metal ion transport system permease component
I6I41_RS23125	COG1464	Belongs to the NlpA lipoprotein family
I6I41_RS23130	COG1464	Belongs to the NlpA lipoprotein family
I6I41_RS23135	COG0396	ATPase activity
I6I41_RS23140	COG0719	Fe-S assembly protein
I6I41_RS23145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I41_RS23150	COG0822	iron-sulfur transferase activity
I6I41_RS23155	COG0719	Fe-S assembly protein
I6I41_RS23160	COG0737	Belongs to the 5'-nucleotidase family
I6I41_RS23165	COG3377	Domain of unknown function (DUF1805)
I6I41_RS23175	COG0739	heme binding
I6I41_RS23200	COG4377	Putative membrane peptidase family (DUF2324)
I6I41_RS23205	COG0789	Transcriptional regulator
I6I41_RS23215	COG4470	Protein conserved in bacteria
I6I41_RS23235	COG1494	fructose-1,6-bisphosphatase
I6I41_RS23240	COG2445	Protein of unknown function DUF86
I6I41_RS23250	COG0647	UMP catabolic process
I6I41_RS23260	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I41_RS23265	COG1136	(ABC) transporter
I6I41_RS23265	COG0577	efflux transmembrane transporter activity
I6I41_RS23280	COG1358	cellular component organization or biogenesis
I6I41_RS23300	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I41_RS23305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I41_RS23315	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I41_RS23320	COG4837	Protein of unknown function (DUF1462)
I6I41_RS23345	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I41_RS23350	COG0390	transport system, permease component
I6I41_RS23355	COG2274	protein secretion by the type I secretion system
I6I41_RS23365	COG1252	NADH dehydrogenase
I6I41_RS23380	COG0316	Belongs to the HesB IscA family
I6I41_RS23400	COG1683	Conserved Protein
I6I41_RS23415	COG3708	Transcriptional regulator
I6I41_RS23430	COG1252	NADH dehydrogenase
I6I41_RS23445	COG3584	3D domain protein
I6I41_RS23455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I41_RS23460	COG2076	Multidrug Resistance protein
I6I41_RS23480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I41_RS23485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I41_RS23495	COG1268	BioY protein
I6I41_RS23505	COG2050	protein possibly involved in aromatic compounds catabolism
I6I41_RS23525	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I41_RS23530	COG5018	Exonuclease
I6I41_RS23550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I41_RS23560	COG2267	carboxylic ester hydrolase activity
I6I41_RS23565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I41_RS23570	COG1522	sequence-specific DNA binding
I6I41_RS23575	COG0436	Aminotransferase
I6I41_RS23580	COG1098	S1 RNA binding domain
I6I41_RS23585	COG2155	Conserved Protein
I6I41_RS23600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I41_RS23605	COG1285	pathogenesis
I6I41_RS23640	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I41_RS23740	COG1404	Belongs to the peptidase S8 family
I6I41_RS23760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6I41_RS23770	COG0058	SHG alpha-glucan phosphorylase activity
I6I41_RS23795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I41_RS23800	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I41_RS23805	COG1169	isochorismate synthase
I6I41_RS23815	COG0596	Alpha beta hydrolase
I6I41_RS23820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I41_RS23830	COG4948	Mandelate Racemase Muconate Lactonizing
I6I41_RS23850	COG3964	amidohydrolase
I6I41_RS23870	COG2188	Transcriptional regulator
I6I41_RS23895	COG0577	efflux transmembrane transporter activity
I6I41_RS23900	COG1136	(ABC) transporter
I6I41_RS23905	COG0577	efflux transmembrane transporter activity
I6I41_RS23910	COG0577	efflux transmembrane transporter activity
I6I41_RS23915	COG2205	protein histidine kinase activity
I6I41_RS23920	COG0745	RESPONSE REGULATOR receiver
I6I41_RS23925	COG0640	Transcriptional regulator
I6I41_RS23930	COG5658	integral membrane protein
I6I41_RS23950	COG3708	Transcriptional regulator
I6I41_RS23950	COG2207	Transcriptional regulator
I6I41_RS23955	COG1136	(ABC) transporter
I6I41_RS23960	COG0577	efflux transmembrane transporter activity
I6I41_RS23970	COG0586	Pfam SNARE associated Golgi protein
I6I41_RS24015	COG1597	lipid kinase activity
I6I41_RS24020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6I41_RS24045	COG0745	RESPONSE REGULATOR receiver
I6I41_RS24050	COG5002	protein histidine kinase activity
I6I41_RS24080	COG1842	Phage shock protein A
I6I41_RS24105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I41_RS24120	COG1294	oxidase, subunit
I6I41_RS24125	COG1271	oxidase subunit
I6I41_RS24130	COG0288	reversible hydration of carbon dioxide
I6I41_RS24140	COG1854	S-ribosylhomocysteine lyase activity
I6I41_RS24170	COG0494	nUDIX hydrolase
I6I41_RS24195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I41_RS24200	COG1116	anion transmembrane transporter activity
I6I41_RS24205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I41_RS24230	COG1368	sulfuric ester hydrolase activity
I6I41_RS24235	COG2267	carboxylic ester hydrolase activity
I6I41_RS24245	COG0753	catalase activity
I6I41_RS24250	COG3852	Histidine kinase
I6I41_RS24255	COG5002	protein histidine kinase activity
I6I41_RS24295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS24315	COG0438	transferase activity, transferring glycosyl groups
I6I41_RS24320	COG0671	phosphoesterase, PA-phosphatase related
I6I41_RS24325	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I41_RS24330	COG2267	carboxylic ester hydrolase activity
I6I41_RS24345	COG1794	racemase activity, acting on amino acids and derivatives
I6I41_RS24355	COG1131	(ABC) transporter
I6I41_RS24360	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6I41_RS24365	COG1242	4 iron, 4 sulfur cluster binding
I6I41_RS24385	COG1136	(ABC) transporter
I6I41_RS24395	COG0582	viral genome integration into host DNA
I6I41_RS24400	COG0490	domain, Protein
I6I41_RS24405	COG0475	glutathione-regulated potassium exporter activity
I6I41_RS24410	COG2814	Major facilitator Superfamily
I6I41_RS24450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I41_RS24460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I41_RS24480	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I41_RS24485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I41_RS24495	COG0303	'Molybdopterin
I6I41_RS24500	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6I41_RS24505	COG0314	molybdopterin synthase activity
I6I41_RS24530	COG1329	Transcriptional regulator
I6I41_RS24550	COG3832	glyoxalase III activity
I6I41_RS24560	COG2814	Major facilitator Superfamily
I6I41_RS24565	COG2081	HI0933 family
I6I41_RS24570	COG2244	polysaccharide biosynthetic process
I6I41_RS24575	COG1187	pseudouridine synthase activity
I6I41_RS24580	COG1349	DNA-binding transcription factor activity
I6I41_RS24585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I41_RS24595	COG1523	belongs to the glycosyl hydrolase 13 family
I6I41_RS24600	COG0510	thiamine kinase activity
I6I41_RS24615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I41_RS24625	COG1363	Peptidase, m42
I6I41_RS24630	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6I41_RS24635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I41_RS24645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I41_RS24655	COG1388	LysM domain
I6I41_RS24655	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I41_RS24660	COG1674	ftsk spoiiie
I6I41_RS24675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS24690	COG2309	aminopeptidase activity
I6I41_RS24700	COG3118	belongs to the thioredoxin family
I6I41_RS24705	COG4851	CamS sex pheromone cAM373 precursor
I6I41_RS24710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6I41_RS24710	COG1605	Chorismate mutase
I6I41_RS24715	COG1609	Transcriptional regulator
I6I41_RS24750	COG0666	response to abiotic stimulus
I6I41_RS24760	COG0745	RESPONSE REGULATOR receiver
I6I41_RS24775	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6I41_RS24780	COG0517	IMP dehydrogenase activity
I6I41_RS24785	COG0454	-acetyltransferase
I6I41_RS24790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I41_RS24795	COG0110	maltose O-acetyltransferase activity
I6I41_RS24840	COG0626	cystathionine gamma-synthase activity
I6I41_RS24845	COG1956	GAF domain-containing protein
I6I41_RS24850	COG1309	transcriptional regulator
I6I41_RS24855	COG0697	spore germination
I6I41_RS24860	COG0583	DNA-binding transcription factor activity
I6I41_RS24870	COG1104	cysteine desulfurase activity
I6I41_RS24885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I41_RS24895	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6I41_RS24910	COG3874	Sporulation protein YtfJ
I6I41_RS24915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I41_RS24920	COG0827	DNA restriction-modification system
I6I41_RS24945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I41_RS24985	COG0589	response to stress
I6I41_RS24990	COG1028	Short-chain dehydrogenase reductase Sdr
I6I41_RS25005	COG0662	Cupin 2, conserved barrel domain protein
I6I41_RS25010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I41_RS25040	COG0006	proline dipeptidase activity
I6I41_RS25055	COG4109	DRTGG domain
I6I41_RS25070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I41_RS25085	COG0587	DNA-directed DNA polymerase activity
I6I41_RS25090	COG0281	malic enzyme
I6I41_RS25095	COG1725	Transcriptional regulator
I6I41_RS25120	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6I41_RS25125	COG0628	permease
I6I41_RS25135	COG0372	Belongs to the citrate synthase family
I6I41_RS25140	COG0538	isocitrate dehydrogenase activity
I6I41_RS25160	COG0745	RESPONSE REGULATOR receiver
I6I41_RS25165	COG5002	protein histidine kinase activity
I6I41_RS25170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I41_RS25170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I41_RS25180	COG1971	Probably functions as a manganese efflux pump
I6I41_RS25190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I41_RS25195	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6I41_RS25205	COG3611	Membrane attachment protein
I6I41_RS25210	COG1484	DNA-dependent DNA replication
I6I41_RS25225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I41_RS25250	COG1363	Peptidase, m42
I6I41_RS25255	COG1309	transcriptional regulator
I6I41_RS25260	COG1566	PFAM secretion protein HlyD family protein
I6I41_RS25265	COG2814	Major facilitator Superfamily
I6I41_RS25275	COG1418	mRNA catabolic process
I6I41_RS25285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I41_RS25325	COG1286	toxin biosynthetic process
I6I41_RS25330	COG1796	DNA polymerase
I6I41_RS25330	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I41_RS25340	COG1187	pseudouridine synthase activity
I6I41_RS25345	COG1114	Component of the transport system for branched-chain amino acids
I6I41_RS25350	COG5386	Cell surface protein
I6I41_RS25360	COG5386	Cell surface protein
I6I41_RS25375	COG1120	ATPase activity
I6I41_RS25380	COG4509	Sortase family
I6I41_RS25390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I41_RS25395	COG4895	conserved protein (DUF2196)
I6I41_RS25405	COG0745	RESPONSE REGULATOR receiver
I6I41_RS25410	COG2205	protein histidine kinase activity
I6I41_RS25415	COG1131	(ABC) transporter
I6I41_RS25440	COG2318	DinB family
I6I41_RS25465	COG0318	PFAM AMP-dependent synthetase and ligase
I6I41_RS25470	COG1309	transcriptional regulator
I6I41_RS25475	COG1024	Enoyl-CoA hydratase
I6I41_RS25480	COG2086	electron transfer activity
I6I41_RS25485	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6I41_RS25490	COG3118	belongs to the thioredoxin family
I6I41_RS25500	COG1719	4-vinyl reductase, 4VR
I6I41_RS25505	COG2009	succinate dehydrogenase
I6I41_RS25510	COG1053	succinate dehydrogenase
I6I41_RS25515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I41_RS25520	COG0824	Thioesterase
I6I41_RS25525	COG1876	peptidase activity
I6I41_RS25530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6I41_RS25535	COG1360	Flagellar Motor Protein
I6I41_RS25540	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6I41_RS25545	COG4152	abc transporter atp-binding protein
I6I41_RS25550	COG1668	transmembrane transport
I6I41_RS25555	COG1959	2 iron, 2 sulfur cluster binding
I6I41_RS25565	COG0697	spore germination
I6I41_RS25570	COG1396	sequence-specific DNA binding
I6I41_RS25575	COG1983	PspC domain protein
I6I41_RS25580	COG0402	S-adenosylhomocysteine deaminase activity
I6I41_RS25585	COG2233	PERMEase
I6I41_RS25590	COG2197	response regulator
I6I41_RS25600	COG1309	transcriptional regulator
I6I41_RS25620	COG5401	PFAM Sporulation and spore germination
I6I41_RS25635	COG0622	Phosphoesterase
I6I41_RS25680	COG0470	DNA polymerase III
I6I41_RS25680	COG1067	ATP-dependent peptidase activity
I6I41_RS25695	COG1764	response to oxidative stress
I6I41_RS25700	COG1846	Transcriptional regulator
I6I41_RS25710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I41_RS25720	COG1587	Uroporphyrinogen-III synthase
I6I41_RS25725	COG0113	porphobilinogen synthase activity
I6I41_RS25735	COG1388	LysM domain
I6I41_RS25750	COG0285	dihydrofolate synthase activity
I6I41_RS25770	COG1077	Cell shape determining protein MreB Mrl
I6I41_RS25790	COG2894	cell division
I6I41_RS25795	COG0739	heme binding
I6I41_RS25800	COG1994	Peptidase M50
I6I41_RS25805	COG1530	ribonuclease E activity
I6I41_RS25815	COG2868	ribosomal protein
I6I41_RS25825	COG3290	protein histidine kinase activity
I6I41_RS25835	COG0745	RESPONSE REGULATOR receiver
I6I41_RS25840	COG5002	protein histidine kinase activity
I6I41_RS25845	COG1136	(ABC) transporter
I6I41_RS25850	COG0577	efflux transmembrane transporter activity
I6I41_RS25855	COG0577	efflux transmembrane transporter activity
I6I41_RS25860	COG0077	Prephenate dehydratase
I6I41_RS25865	COG2258	MOSC domain
I6I41_RS25870	COG1827	regulation of RNA biosynthetic process
I6I41_RS25875	COG1104	cysteine desulfurase activity
I6I41_RS25880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I41_RS25885	COG0157	Belongs to the NadC ModD family
I6I41_RS25915	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6I41_RS25945	COG1862	Preprotein translocase
I6I41_RS25955	COG2323	membrane
I6I41_RS25960	COG2244	polysaccharide biosynthetic process
I6I41_RS25970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I41_RS25970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I41_RS25975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I41_RS25980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I41_RS25980	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6I41_RS25990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I41_RS26015	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I41_RS26025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I41_RS26030	COG1959	2 iron, 2 sulfur cluster binding
I6I41_RS26035	COG1104	cysteine desulfurase activity
I6I41_RS26050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I41_RS26070	COG0628	permease
I6I41_RS26100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I41_RS26105	COG4122	O-methyltransferase activity
I6I41_RS26110	COG0826	peptidase U32
I6I41_RS26115	COG0826	peptidase U32
I6I41_RS26135	COG0768	penicillin binding
I6I41_RS26160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I41_RS26165	COG0626	cystathionine gamma-synthase activity
I6I41_RS26170	COG1012	belongs to the aldehyde dehydrogenase family
I6I41_RS26170	COG1454	alcohol dehydrogenase
I6I41_RS26180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I41_RS26220	COG2259	Doxx family
I6I41_RS26225	COG2514	catechol 2,3-dioxygenase activity
I6I41_RS26235	COG3186	Phenylalanine-4-hydroxylase
I6I41_RS26240	COG1404	Belongs to the peptidase S8 family
I6I41_RS26275	COG2267	carboxylic ester hydrolase activity
I6I41_RS26285	COG1785	Belongs to the alkaline phosphatase family
I6I41_RS26295	COG2357	RelA SpoT domain protein
I6I41_RS26300	COG0778	Nitroreductase
I6I41_RS26335	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6I41_RS26340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6I41_RS26350	COG1534	Rna-binding protein
I6I41_RS26360	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6I41_RS26365	COG0799	negative regulation of ribosome biogenesis
I6I41_RS26370	COG2226	methyltransferase
I6I41_RS26375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I41_RS26380	COG1555	photosystem II stabilization
I6I41_RS26380	COG1596	polysaccharide export
I6I41_RS26385	COG2131	deaminase
I6I41_RS26390	COG2333	competence protein COMEC
I6I41_RS26390	COG0658	competence protein
I6I41_RS26400	COG1466	dna polymerase III delta subunit
I6I41_RS26425	COG1733	regulation of RNA biosynthetic process
I6I41_RS26430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I41_RS26460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I41_RS26465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I41_RS26470	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I41_RS26475	COG1610	YqeY-like protein
I6I41_RS26495	COG1702	phosphate starvation-inducible protein PhoH
I6I41_RS26500	COG1480	7TM receptor with intracellular HD hydrolase
I6I41_RS26510	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I41_RS26515	COG0295	cytidine deaminase activity
I6I41_RS26520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I41_RS26535	COG0517	IMP dehydrogenase activity
I6I41_RS26550	COG0358	DNA primase activity
I6I41_RS26555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I41_RS26565	COG2384	SAM-dependent methyltransferase
I6I41_RS26570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family