locus-tag class description FOC93_RS00010 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC93_RS00030 ENOG4105DVH amino acid FOC93_RS00045 ENOG4105MZU cell filamentation protein FOC93_RS00050 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC93_RS00065 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC93_RS00075 ENOG4106A3M Cytochrome p-450 FOC93_RS00095 ENOG4107RA9 decarboxylase FOC93_RS00140 ENOG4107SCK Monooxygenase FOC93_RS00145 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC93_RS00150 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC93_RS00155 ENOG4107QHE Choloylglycine hydrolase FOC93_RS00165 ENOG4108NHD germination protein FOC93_RS00175 ENOG4105VEQ Cold shock protein FOC93_RS00195 ENOG4108VJ1 Transcriptional regulator (CarD family FOC93_RS00225 ENOG4105DRR Transcriptional regulator, GntR family FOC93_RS00250 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FOC93_RS00260 ENOG4108JJA ABC, transporter FOC93_RS00290 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_RS00330 ENOG4105PF9 Transcriptional regulator FOC93_RS00335 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_RS00340 ENOG4105C0W non-ribosomal peptide synthetase FOC93_RS00345 ENOG4107SQU synthase FOC93_RS00350 ENOG4107SQU synthase FOC93_RS00355 ENOG4105C0W non-ribosomal peptide synthetase FOC93_RS00360 ENOG4105C0W non-ribosomal peptide synthetase FOC93_RS00365 ENOG4107SQU synthase FOC93_RS00370 ENOG4105C0W non-ribosomal peptide synthetase FOC93_RS00375 ENOG4105C0W non-ribosomal peptide synthetase FOC93_RS00380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC93_RS00385 ENOG4107QKG PfaD family FOC93_RS00390 ENOG4108151 Beta-lactamase domain protein FOC93_RS00415 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC93_RS00495 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC93_RS00520 ENOG41067FT ParB-like nuclease domain FOC93_RS00550 ENOG4105TRI Hydrolase FOC93_RS00590 ENOG4105IBP Cyclic peptide transporter FOC93_RS00595 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC93_RS00600 ENOG4105C0W non-ribosomal peptide synthetase FOC93_RS00615 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) FOC93_RS00620 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC93_RS00635 ENOG4105C1G acyl-Coa dehydrogenase FOC93_RS00645 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_RS00655 ENOG4105C0W non-ribosomal peptide synthetase FOC93_RS00655 ENOG4105C0W non-ribosomal peptide synthetase FOC93_RS00670 ENOG4107SDT Homocitrate synthase FOC93_RS00690 ENOG4105CUZ uba thif-type nad fad binding protein FOC93_RS00720 ENOG4107QJQ Mate efflux family protein FOC93_RS00725 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FOC93_RS00730 ENOG41087PP glycosyltransferase MGT family FOC93_RS00735 ENOG4105KNA -acetyltransferase FOC93_RS00750 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FOC93_RS00755 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FOC93_RS00765 ENOG41080TC multidrug resistance protein FOC93_RS00790 ENOG4107SET aldo keto reductase FOC93_RS00810 ENOG4105CFF transcriptional regulator FOC93_RS00850 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC93_RS00865 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC93_RS00905 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC93_RS00955 ENOG4105K70 DNA-binding protein FOC93_RS00975 ENOG4107JM4 Tetratricopeptide repeat FOC93_RS00980 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC93_RS01055 ENOG4105CAQ asparagine synthetase FOC93_RS01060 ENOG4108RZE Tetr family transcriptional regulator FOC93_RS01155 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC93_RS01170 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC93_RS01175 ENOG4105DR5 peptidase FOC93_RS01180 ENOG41065S2 pneumococcal vaccine antigen FOC93_RS01270 ENOG4105E4C Lytic transglycosylase catalytic FOC93_RS01280 ENOG41069ER domain protein FOC93_RS01290 ENOG4107JM4 Tetratricopeptide repeat FOC93_RS01355 ENOG4105CJW magnesium transporter FOC93_RS01505 ENOG4105DQ6 Transposase FOC93_RS01575 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC93_RS01605 ENOG4105D7V transposase FOC93_RS01625 ENOG4105KRN Transcriptional regulator, abrb family FOC93_RS01690 ENOG4105D7V transposase FOC93_RS01715 ENOG4108IQI permease FOC93_RS01720 ENOG4108J5H Homocysteine s-methyltransferase FOC93_RS01730 ENOG4105BZU Histidine kinase FOC93_RS01735 ENOG4105C19 ABC transporter FOC93_RS01745 ENOG4105DNP FAD linked oxidase domain protein FOC93_RS01785 ENOG4105BZ4 penicillin-binding protein FOC93_RS01830 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC93_RS01835 ENOG4108BUD transposase FOC93_RS01845 ENOG4105C19 ABC transporter FOC93_RS01860 ENOG41081I9 integral membrane protein FOC93_RS01875 ENOG4108BUD transposase FOC93_RS01885 ENOG410780I phosphoprotein phosphatase activity FOC93_RS01965 ENOG4105NA0 Transcriptional regulator FOC93_RS01970 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC93_RS02015 ENOG4107SWG transcriptional regulator MERR family FOC93_RS02020 ENOG4105KNA -acetyltransferase FOC93_RS02030 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FOC93_RS02040 ENOG4105G9B Transcriptional regulator FOC93_RS02150 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC93_RS02165 ENOG4105BZ1 (ABC) transporter FOC93_RS02175 ENOG4108WUH Transcriptional regulator, TetR family FOC93_RS02195 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_RS02205 ENOG4107RN3 metallophosphoesterase FOC93_RS02240 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FOC93_RS02245 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_RS02330 ENOG4105D7V transposase FOC93_RS02365 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC93_RS02370 ENOG4107QQG Dehydrogenase FOC93_RS02430 ENOG4105CK5 oxidoreductase FOC93_RS02435 ENOG4105CK5 oxidoreductase FOC93_RS02455 ENOG4105CNU cell division protein FtsK FOC93_RS02615 ENOG4105CID antiterminator FOC93_RS02620 ENOG4105C5Y PTS System FOC93_RS02625 ENOG4105CS2 ec 3.2.1.21 FOC93_RS02730 ENOG4105EKQ RNA-directed DNA polymerase FOC93_RS02770 ENOG4105D7V transposase FOC93_RS02795 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) FOC93_RS02810 ENOG4105DHF Membrane FOC93_RS02880 ENOG4108KS4 Spore coat protein FOC93_RS02885 ENOG4107SBE Glycosyl transferase (Group 1 FOC93_RS02905 ENOG4107SBE Glycosyl transferase (Group 1 FOC93_RS02910 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC93_RS03140 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC93_RS03175 ENOG4105F6J Alpha beta hydrolase fold FOC93_RS03190 ENOG4105F6J Alpha beta hydrolase fold FOC93_RS03215 ENOG4105XT2 Transcriptional regulator FOC93_RS03240 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC93_RS03250 ENOG4107RSM transcriptional regulator FOC93_RS03255 ENOG4107AYK membrAne FOC93_RS03260 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC93_RS03270 ENOG4105K70 DNA-binding protein FOC93_RS03290 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC93_RS03325 ENOG4108W2Y isochorismatase FOC93_RS03345 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FOC93_RS03355 ENOG4105ST3 Transcriptional regulator FOC93_RS03405 ENOG4108903 Formimidoylglutamase FOC93_RS03410 ENOG4108VJ1 Transcriptional regulator (CarD family FOC93_RS03415 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC93_RS03420 ENOG4105CBC glutamate synthase FOC93_RS03430 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC93_RS03435 ENOG4105FBA Phospholipase Carboxylesterase FOC93_RS03440 ENOG4105BZU Histidine kinase FOC93_RS03450 ENOG4107AYK membrAne FOC93_RS03490 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FOC93_RS03505 ENOG4105IW1 AmiS UreI transporter FOC93_RS03510 ENOG4105D9G High-affinity FOC93_RS03535 ENOG4108IMY Transcriptional regulator FOC93_RS03540 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_RS03545 ENOG4107ZYJ bioY protein FOC93_RS03550 ENOG4107F3J Amp-dependent synthetase and ligase FOC93_RS03570 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC93_RS03580 ENOG4105E5W Transporter FOC93_RS03610 ENOG4108I0Z Aconitate hydratase FOC93_RS03615 ENOG4105BZ1 (ABC) transporter FOC93_RS03630 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC93_RS03635 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC93_RS03665 ENOG4105W8X HesB YadR YfhF-family protein FOC93_RS03675 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC93_RS03685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS03690 ENOG4105C0H protease FOC93_RS03695 ENOG4105K4P CoA-binding domain protein FOC93_RS03700 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC93_RS03710 ENOG4105D9R oxidoreductase FOC93_RS03730 ENOG4105CIG ABC transporter FOC93_RS03740 ENOG4105EMN RNA polymerase sigma factor FOC93_RS03750 ENOG4108KGH TRANSCRIPTIONal FOC93_RS03805 ENOG4105CUB amino acid FOC93_RS03820 ENOG4105E1K spore germination protein FOC93_RS03825 ENOG4108JB9 formate dehydrogenase FOC93_RS03835 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC93_RS03840 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC93_RS03850 ENOG4105TMB Formate nitrite transporter FOC93_RS03855 ENOG4105D06 uba thif-type nad fad binding protein FOC93_RS03860 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC93_RS03865 ENOG4108ZAF Molybdopterin FOC93_RS03875 ENOG4105D1F ATP-binding protein FOC93_RS03890 ENOG410696E Membrane FOC93_RS03895 ENOG4105FR1 rard protein FOC93_RS03905 ENOG4105EWU Squalene--hopene cyclase FOC93_RS03915 ENOG4105CHR reductase FOC93_RS03920 ENOG4105C26 Dehydrogenase FOC93_RS03930 ENOG4108IA2 Sodium pantothenate symporter FOC93_RS03945 ENOG4106IQC argininosuccinate lyase FOC93_RS03955 ENOG410904N short-chain dehydrogenase reductase FOC93_RS03975 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC93_RS04000 ENOG4105VEQ Cold shock protein FOC93_RS04015 ENOG4108R1P FOC93_RS04025 ENOG41073R8 VanW family FOC93_RS04030 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC93_RS04040 ENOG4105KT7 mgtC SapB transporter FOC93_RS04050 ENOG4105BZU Histidine kinase FOC93_RS04070 ENOG4107DUR UPF0457 protein FOC93_RS04080 ENOG4105C5H ABC transporter FOC93_RS04085 ENOG4105BZU Histidine kinase FOC93_RS04145 ENOG4105D7V transposase FOC93_RS04150 ENOG4105FAW cDP-glucose 4,6-dehydratase FOC93_RS04155 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC93_RS04165 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FOC93_RS04185 ENOG4105E1K spore germination protein FOC93_RS04195 ENOG4108M1A Chitin-binding protein FOC93_RS04200 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FOC93_RS04210 ENOG4105CEP NADH dehydrogenase FOC93_RS04215 ENOG4107TPS domain protein FOC93_RS04220 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC93_RS04245 ENOG4105CQB FAD linked oxidase domain protein FOC93_RS04270 ENOG4105CIS alcohol dehydrogenase FOC93_RS04275 ENOG41082BM Transcriptional regulator, arsr family FOC93_RS04285 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC93_RS04310 ENOG4108A04 Beta-lactamase FOC93_RS04315 ENOG4105DPN Oligoendopeptidase f FOC93_RS04320 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC93_RS04330 ENOG4105C98 muts2 protein FOC93_RS04345 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC93_RS04355 ENOG4107V2S Transcriptional regulator FOC93_RS04365 ENOG4107CUJ Protein of unknown function (DUF2690) FOC93_RS04370 ENOG41068WN FOC93_RS04395 ENOG4105DQ5 transport system permease protein FOC93_RS04400 ENOG4105EHG Permease protein FOC93_RS04405 ENOG4108MES Periplasmic binding protein FOC93_RS04410 ENOG4105WCN acetyltransferase FOC93_RS04420 ENOG4107R3E Citrate transporter FOC93_RS04430 ENOG4108TN2 lmbE family FOC93_RS04500 ENOG4105H3G oxidoreductase FOC93_RS04525 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC93_RS04555 ENOG4105KAF membrAne FOC93_RS04575 ENOG410829K Lysine exporter protein (Lyse ygga) FOC93_RS04630 ENOG4105KVH Transcriptional regulator FOC93_RS04635 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC93_RS04645 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC93_RS04685 ENOG4105D9R oxidoreductase FOC93_RS04690 ENOG4108TZY GntR Family Transcriptional Regulator FOC93_RS04720 ENOG4105C44 Serine transporter FOC93_RS04745 ENOG4105KVH Transcriptional regulator FOC93_RS04750 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOC93_RS04755 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC93_RS04760 ENOG4108UX3 '-nucleotidase FOC93_RS04765 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_RS04790 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC93_RS04795 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOC93_RS04805 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC93_RS04810 ENOG4105C6Z Gluconate FOC93_RS04815 ENOG4105CMG Carbohydrate kinase FOC93_RS04820 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC93_RS04825 ENOG4105XDF Protein of unknown function (DUF1272) FOC93_RS04830 ENOG4105DDN Pentapeptide repeat-containing protein FOC93_RS04860 ENOG4105FAW cDP-glucose 4,6-dehydratase FOC93_RS04865 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FOC93_RS04880 ENOG4105C37 (CBS) domain FOC93_RS04910 ENOG4105EV4 Multidrug resistance protein mdtH FOC93_RS05025 ENOG4108PSK reductase FOC93_RS05055 ENOG4108RCM Nitroreductase FOC93_RS05060 ENOG4105KVH Transcriptional regulator FOC93_RS05075 ENOG4105CUT histidyl-tRNA synthetase FOC93_RS05080 ENOG4108Z66 YbaK ebsC protein FOC93_RS05100 ENOG4108K8S endonuclease I FOC93_RS05160 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC93_RS05170 ENOG4105CRW Short chain fatty acid transporter FOC93_RS05185 ENOG4105CZM Major Facilitator FOC93_RS05190 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC93_RS05205 ENOG4108ISG Major Facilitator FOC93_RS05215 ENOG4105PNM synthesis protein FOC93_RS05220 ENOG4108VXD carboxy-peptidase FOC93_RS05335 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC93_RS05370 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOC93_RS05405 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC93_RS05415 ENOG4105BZU Histidine kinase FOC93_RS05435 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC93_RS05455 ENOG4105JQZ Methyltransferase FOC93_RS05465 ENOG4105E0Y RtcB Protein FOC93_RS05475 ENOG4105K6H D-cysteine desulfhydrase FOC93_RS05490 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_RS05495 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC93_RS05590 ENOG4108YXU transcriptional regulator AsnC family FOC93_RS05595 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC93_RS05600 ENOG4105M4P Tetr family transcriptional regulator FOC93_RS05605 ENOG4105F27 Major Facilitator FOC93_RS05625 ENOG4105EQ0 Major Facilitator superfamily FOC93_RS05630 ENOG4108JGH Tetr family transcriptional regulator FOC93_RS05635 ENOG4108IG5 Transcriptional regulator FOC93_RS05640 ENOG4107P5I polyketide synthase FOC93_RS05665 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC93_RS05690 ENOG41085FC arsR family transcriptional regulator FOC93_RS05695 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC93_RS05700 ENOG4105D6J arsenicaL-resistance protein FOC93_RS05710 ENOG4105Z7P Acetyltransferase (GNAT) family FOC93_RS05715 ENOG4105ECQ AraC Family Transcriptional Regulator FOC93_RS05720 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC93_RS05735 ENOG4105C57 major facilitator superfamily FOC93_RS05740 ENOG41062ES Transcriptional regulator FOC93_RS05775 ENOG4105FR1 rard protein FOC93_RS05790 ENOG4108VJ1 Transcriptional regulator (CarD family FOC93_RS05815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS05820 ENOG4105BZU Histidine kinase FOC93_RS05825 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC93_RS05840 ENOG4106P55 Transcriptional regulator FOC93_RS05845 ENOG4105F27 Major Facilitator FOC93_RS05850 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC93_RS05855 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC93_RS05870 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC93_RS05875 ENOG4108606 TspO/MBR family FOC93_RS05890 ENOG4105F6J Alpha beta hydrolase fold FOC93_RS05945 ENOG4105EQ0 Major Facilitator superfamily FOC93_RS05970 ENOG4105CHJ isochorismatase hydrolase FOC93_RS05980 ENOG4105CGH 5'-nucleotidase FOC93_RS06030 ENOG4108Q8B Spore germination protein FOC93_RS06035 ENOG4108NHD germination protein FOC93_RS06040 ENOG4105II7 pyrroline-5-carboxylate reductase FOC93_RS06045 ENOG4105CUB amino acid FOC93_RS06050 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC93_RS06055 ENOG4105YWU small acid-soluble spore protein FOC93_RS06065 ENOG41075H3 AraC family transcriptional regulator FOC93_RS06090 ENOG4105BZU Histidine kinase FOC93_RS06100 ENOG4108B31 Spore germination protein FOC93_RS06125 ENOG4108IMY Transcriptional regulator FOC93_RS06130 ENOG4105HDK L-asparaginase FOC93_RS06135 ENOG4108IJ0 Aspartate ammonia-lyase FOC93_RS06145 ENOG4105E2A Dehydrogenase FOC93_RS06170 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC93_RS06195 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC93_RS06230 ENOG4105DWD nucleoside recognition domain protein FOC93_RS06245 ENOG4105FDT acyl-CoA dehydrogenase FOC93_RS06255 ENOG4108ZHR arsR family transcriptional regulator FOC93_RS06260 ENOG4106N3A copper homeostasis protein cutc FOC93_RS06270 ENOG4107258 Transcriptional regulator FOC93_RS06275 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC93_RS06285 ENOG4105E7W lamb ycsf family protein FOC93_RS06305 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC93_RS06310 ENOG4107RF6 penicillin-binding protein FOC93_RS06345 ENOG4105F1N DNA alkylation repair FOC93_RS06355 ENOG4108IQI permease FOC93_RS06365 ENOG410635A Membrane FOC93_RS06410 ENOG4108PCN EamA-like transporter family FOC93_RS06425 ENOG4108XET gCN5-related N-acetyltransferase FOC93_RS06430 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) FOC93_RS06470 ENOG4105FS7 Transcriptional regulator FOC93_RS06475 ENOG4108TVJ Nitroreductase FOC93_RS06560 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC93_RS06605 ENOG4105C8Y Acetylornithine aminotransferase FOC93_RS06630 ENOG4105CKK Glycosyl transferase, family 2 FOC93_RS06640 ENOG4105CSH Transporter FOC93_RS06655 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC93_RS06680 ENOG41068WN FOC93_RS06700 ENOG4105VMP Transcriptional regulator FOC93_RS06710 ENOG4105G6Z alkaline phosphatase FOC93_RS06715 ENOG4107RBI VanW family FOC93_RS06725 ENOG4105ECK Fatty Acid Desaturase FOC93_RS06745 ENOG4107258 Transcriptional regulator FOC93_RS06755 ENOG4105II7 pyrroline-5-carboxylate reductase FOC93_RS06790 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC93_RS06800 ENOG41061GT Aldolase FOC93_RS06815 ENOG4105DKT Transcriptional regulator FOC93_RS06825 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC93_RS06835 ENOG4105D4B ABC, transporter FOC93_RS06865 ENOG4105DNP FAD linked oxidase domain protein FOC93_RS06870 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC93_RS06880 ENOG41069ER domain protein FOC93_RS06905 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC93_RS06925 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC93_RS06930 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC93_RS06955 ENOG41082JN Transcriptional regulator FOC93_RS06960 ENOG4105EYF MMPL domain protein FOC93_RS06965 ENOG4105C5H ABC transporter FOC93_RS06970 ENOG4105E0M Sulfatase FOC93_RS06975 ENOG4108ZCF integral membrane protein FOC93_RS06990 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC93_RS06995 ENOG4107VC0 DNA alkylation repair enzyme FOC93_RS07045 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC93_RS07070 ENOG4105D7T ABC transporter FOC93_RS07075 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC93_RS07080 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC93_RS07085 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC93_RS07095 ENOG4105C02 permease FOC93_RS07145 ENOG4105DVE abc transporter atp-binding protein FOC93_RS07175 ENOG4105CHM Aminotransferase FOC93_RS07210 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FOC93_RS07225 ENOG4107BMA Transglycosylase associated protein FOC93_RS07250 ENOG4106K7D Major facilitator family transporter FOC93_RS07255 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC93_RS07315 ENOG4105EPR degv family FOC93_RS07320 ENOG4105DPN Oligoendopeptidase f FOC93_RS07335 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FOC93_RS07355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS07360 ENOG4105BZU Histidine kinase FOC93_RS07365 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC93_RS07370 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC93_RS07405 ENOG4107SET aldo keto reductase FOC93_RS07420 ENOG4105DTQ mandelate racemase muconate lactonizing FOC93_RS07440 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC93_RS07450 ENOG4107T5V SNARE associated Golgi FOC93_RS07455 ENOG4105DCI Phosphohydrolase FOC93_RS07490 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC93_RS07500 ENOG41080HI glycine oxidase FOC93_RS07505 ENOG4105CTU Proline racemase FOC93_RS07515 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC93_RS07520 ENOG4105C26 Dehydrogenase FOC93_RS07525 ENOG4105BZG amino acid carrier protein FOC93_RS07535 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC93_RS07550 ENOG4108M1A Chitin-binding protein FOC93_RS07605 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC93_RS07610 ENOG41066HZ AIG2-like family FOC93_RS07620 ENOG4105EEM helicase FOC93_RS07625 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FOC93_RS07645 ENOG4108Z7F N-acetyltransferase FOC93_RS07670 ENOG4105MSB protein, conserved in bacteria FOC93_RS07675 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC93_RS07705 ENOG4108M1A Chitin-binding protein FOC93_RS07710 ENOG41082BV acetyltransferase FOC93_RS07715 ENOG4105E66 phosphoriboisomerase A FOC93_RS07740 ENOG4108IJ7 Glycine betaine FOC93_RS07745 ENOG4107SQ8 Glycine betaine FOC93_RS07785 ENOG4105RHY Pfam:UPF0157 FOC93_RS07790 ENOG4105E1F short-chain dehydrogenase reductase FOC93_RS07800 ENOG4105JHE Major Facilitator Superfamily FOC93_RS07810 ENOG4107RUY (E1 component), alpha subunit FOC93_RS07820 ENOG4107QKR Dehydrogenase FOC93_RS07840 ENOG41062ES Transcriptional regulator FOC93_RS07855 ENOG4105E98 transcriptional regulator DeoR family FOC93_RS07870 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC93_RS07900 ENOG4107Z3H Transcriptional regulator, TetR family FOC93_RS07905 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC93_RS07910 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC93_RS07940 ENOG4105MSI germination protein ypeb FOC93_RS07990 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC93_RS07995 ENOG4105FDR Membrane FOC93_RS08000 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC93_RS08015 ENOG4105CGH 5'-nucleotidase FOC93_RS08025 ENOG4108IUM Glycogen debranching enzyme FOC93_RS08040 ENOG4105DY8 decarboxylase FOC93_RS08055 ENOG4107WD8 ABC transporter, permease FOC93_RS08075 ENOG4105BZU Histidine kinase FOC93_RS08080 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS08115 ENOG4107VFR oxidoreductase FOC93_RS08155 ENOG4105PKS Excinuclease abc c subunit domain protein FOC93_RS08165 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC93_RS08190 ENOG4105KWG Pfam:DUF1696 FOC93_RS08195 ENOG4108NRW Phospholipase, patatin family FOC93_RS08215 ENOG4108XI2 Domain of unknown function (DUF1963) FOC93_RS08250 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC93_RS08265 ENOG4105FCD Major Facilitator FOC93_RS08290 ENOG4105EGD dinuclear metal center protein, YbgI family FOC93_RS08310 ENOG4107Y9U Membrane FOC93_RS08330 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC93_RS08350 ENOG4105F27 Major Facilitator FOC93_RS08375 ENOG4108Z6Z Transcriptional regulator FOC93_RS08380 ENOG4107SWG transcriptional regulator MERR family FOC93_RS08425 ENOG4105CJN penicillin-binding protein FOC93_RS08430 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC93_RS08435 ENOG4105CB2 alcohol dehydrogenase FOC93_RS08440 ENOG4105GR3 Histidine kinase FOC93_RS08445 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS08520 ENOG4108HGU Histidine kinase FOC93_RS08535 ENOG4108JJB ABC transporter FOC93_RS08565 ENOG4105BZU Histidine kinase FOC93_RS08570 ENOG410667J hydrolase FOC93_RS08700 ENOG4105XSJ toxin secretion phage lysis holin FOC93_RS08795 ENOG4108TFU terminase (Small subunit) FOC93_RS08890 ENOG4105KNA -acetyltransferase FOC93_RS08920 ENOG4108SXZ UPF0302 protein FOC93_RS08945 ENOG4108PNI recT protein FOC93_RS08955 ENOG4108NF7 phage-type endonuclease FOC93_RS08985 ENOG4108IMY Transcriptional regulator FOC93_RS09010 ENOG4105VTR Integrase FOC93_RS09035 ENOG4105ETU transcriptional activator (TenA FOC93_RS09040 ENOG4105CPF Cell wall formation (By similarity) FOC93_RS09050 ENOG4105D6E homoserine dehydrogenase FOC93_RS09120 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC93_RS09130 ENOG4108V4B ThiJ pfpI FOC93_RS09135 ENOG410900G Protein of unknown function (DUF421) FOC93_RS09145 ENOG4105CPQ Dehydrogenase FOC93_RS09160 ENOG4105EFA 4-hydroxyphenylacetate FOC93_RS09205 ENOG41089UC methyltransferase, type 11 FOC93_RS09210 ENOG4105KVH Transcriptional regulator FOC93_RS09220 ENOG4107Y80 Major Facilitator superfamily FOC93_RS09245 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC93_RS09275 ENOG41075H3 AraC family transcriptional regulator FOC93_RS09295 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC93_RS09305 ENOG4105T9C HD domain FOC93_RS09320 ENOG4105DZ1 carboxypeptidase FOC93_RS09340 ENOG4105DBI uridine monophosphokinase FOC93_RS09370 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC93_RS09375 ENOG4107QX3 carboxylase FOC93_RS09380 ENOG4105E39 Enoyl-CoA hydratase FOC93_RS09385 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC93_RS09390 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC93_RS09395 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC93_RS09400 ENOG4105C1G acyl-Coa dehydrogenase FOC93_RS09415 ENOG4107Z3H Transcriptional regulator, TetR family FOC93_RS09425 ENOG4105CJ1 ABC, transporter FOC93_RS09435 ENOG4105DIN metallophosphoesterase FOC93_RS09445 ENOG4107RF6 penicillin-binding protein FOC93_RS09450 ENOG4107RF6 penicillin-binding protein FOC93_RS09465 ENOG4107RVG penicillin-binding protein FOC93_RS09490 ENOG4107QHE Choloylglycine hydrolase FOC93_RS09500 ENOG4105CVK Glutamate decarboxylase FOC93_RS09510 ENOG4105F6S Spore photoproduct lyase FOC93_RS09530 ENOG4105C44 Serine transporter FOC93_RS09535 ENOG4105EJQ L-serine dehydratase FOC93_RS09560 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC93_RS09570 ENOG4108XG2 Histidine kinase FOC93_RS09575 ENOG4105CAQ asparagine synthetase FOC93_RS09580 ENOG4108RZE Tetr family transcriptional regulator FOC93_RS09600 ENOG4108IMY Transcriptional regulator FOC93_RS09665 ENOG4105CHR reductase FOC93_RS09675 ENOG4105W8Z 4'-phosphopantetheinyl transferase FOC93_RS09715 ENOG4105EQK -acetyltransferase FOC93_RS09720 ENOG4105EJ9 Membrane FOC93_RS09730 ENOG4105KRN Transcriptional regulator, abrb family FOC93_RS09755 ENOG4105CIN aminoacyl-histidine dipeptidase FOC93_RS09780 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC93_RS09785 ENOG4105K56 Transcriptional regulator FOC93_RS09790 ENOG4107RA9 decarboxylase FOC93_RS09795 ENOG4108I0C methyltransferase FOC93_RS09805 ENOG41088CC tellurite resistance protein tehB FOC93_RS09830 ENOG4108RZE Tetr family transcriptional regulator FOC93_RS09840 ENOG4105C1J atp-dependent rna helicase FOC93_RS09850 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC93_RS09865 ENOG4108INS Transcriptional regulator FOC93_RS09875 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC93_RS09880 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC93_RS09885 ENOG4105RD7 BadF BadG BcrA BcrD FOC93_RS09910 ENOG4105F32 YngK protein FOC93_RS09940 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FOC93_RS09975 ENOG4108JCI Transcriptional regulator FOC93_RS10000 ENOG4105BZ1 (ABC) transporter FOC93_RS10005 ENOG4105BZ1 (ABC) transporter FOC93_RS10020 ENOG4108RPX mosc domain containing protein FOC93_RS10025 ENOG4105DND Transcriptional regulator FOC93_RS10045 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC93_RS10050 ENOG4107V2S Transcriptional regulator FOC93_RS10080 ENOG41068WN FOC93_RS10090 ENOG4105C1Q protoporphyrinogen oxidase FOC93_RS10115 ENOG4105WCN acetyltransferase FOC93_RS10145 ENOG4105EYF MMPL domain protein FOC93_RS10155 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC93_RS10180 ENOG41081I9 integral membrane protein FOC93_RS10220 ENOG4105C19 ABC transporter FOC93_RS10225 ENOG4105C22 threonyL-tRNA synthetase FOC93_RS10230 ENOG4105FE9 pseudouridine synthase FOC93_RS10250 ENOG4105BZG amino acid carrier protein FOC93_RS10270 ENOG4105K70 DNA-binding protein FOC93_RS10285 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_RS10290 ENOG4105WQT MbtH domain protein FOC93_RS10295 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_RS10300 ENOG4105WQI isochorismatase FOC93_RS10305 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC93_RS10310 ENOG4105E4F Isochorismate synthase FOC93_RS10315 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC93_RS10320 ENOG4105FCD Major Facilitator FOC93_RS10340 ENOG4105EYH Exonuclease FOC93_RS10345 ENOG4107RFY SbcCD D subunit FOC93_RS10360 ENOG4105E39 Enoyl-CoA hydratase FOC93_RS10365 ENOG4105N14 lysine exporter protein LysE YggA FOC93_RS10375 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC93_RS10380 ENOG4105C1G acyl-Coa dehydrogenase FOC93_RS10385 ENOG4105CR4 methylisocitrate lyase FOC93_RS10390 ENOG4105DXD 2-methylcitrate dehydratase FOC93_RS10400 ENOG4105W8X HesB YadR YfhF-family protein FOC93_RS10405 ENOG4105CZM Major Facilitator FOC93_RS10415 ENOG4105BZ4 penicillin-binding protein FOC93_RS10480 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC93_RS10515 ENOG4105SZ6 Thioredoxin FOC93_RS10525 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC93_RS10570 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC93_RS10575 ENOG4108JUB Transcriptional regulator FOC93_RS10580 ENOG4108TSC N-acetyltransferase FOC93_RS10585 ENOG4107S4Y M20 DapE family protein YgeY FOC93_RS10600 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC93_RS10625 ENOG4105C37 (CBS) domain FOC93_RS10660 ENOG4105E90 ABC transporter FOC93_RS10665 ENOG4108IJ8 ABC transporter FOC93_RS10695 ENOG4108YV3 Protein of unknown function (DUF2711) FOC93_RS10705 ENOG4105C6Z Gluconate FOC93_RS10710 ENOG4105CMG Carbohydrate kinase FOC93_RS10730 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC93_RS10735 ENOG4106KNT transcriptional regulator FOC93_RS10740 ENOG4105WH1 Two component transcriptional regulator luxr family FOC93_RS10745 ENOG4105BZU Histidine kinase FOC93_RS10750 ENOG4105D8X mechanosensitive ion channel FOC93_RS10785 ENOG4105F0I Aminotransferase FOC93_RS10790 ENOG4108MES Periplasmic binding protein FOC93_RS10810 ENOG4105CAQ asparagine synthetase FOC93_RS10815 ENOG4107Y70 Heat shock protein FOC93_RS10820 ENOG4108KF3 Electron transport protein SCO1 SenC FOC93_RS10830 ENOG4108RCR degv family FOC93_RS10840 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC93_RS10850 ENOG4108UT2 hemolysin iii FOC93_RS10855 ENOG4105E9Q Acyl-transferase FOC93_RS10860 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC93_RS10865 ENOG4107RVG penicillin-binding protein FOC93_RS10875 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FOC93_RS10880 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC93_RS10895 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC93_RS10920 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC93_RS10925 ENOG4105VMP Transcriptional regulator FOC93_RS10935 ENOG4105KD7 acetyltransferase FOC93_RS10955 ENOG4105CY2 Citrate transporter FOC93_RS10960 ENOG4107XGZ Hydrolase FOC93_RS10980 ENOG4105C8J )-transporter FOC93_RS10985 ENOG4105C5S asparaginyl-tRNA synthetase FOC93_RS11010 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC93_RS11035 ENOG4105C75 arginyL-tRNA synthetase FOC93_RS11040 ENOG4107YX5 Pfam:DUF548 FOC93_RS11065 ENOG4108UUM single-stranded DNA-binding protein FOC93_RS11080 ENOG4105C5H ABC transporter FOC93_RS11120 ENOG4105MCT stage V sporulation protein S FOC93_RS11155 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC93_RS11160 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC93_RS11165 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC93_RS11170 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC93_RS11175 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC93_RS11180 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC93_RS11205 ENOG41067WU Molybdopterin converting factor (Subunit 1) FOC93_RS11210 ENOG4108ZAF Molybdopterin FOC93_RS11215 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC93_RS11220 ENOG4105D06 uba thif-type nad fad binding protein FOC93_RS11225 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC93_RS11230 ENOG4107V6Q Cyclic nucleotide-binding domain FOC93_RS11240 ENOG4105R3A Nitrate reductase FOC93_RS11245 ENOG4108IUE nitrate reductase beta subunit FOC93_RS11255 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC93_RS11270 ENOG4108V06 Glutathione peroxidase FOC93_RS11280 ENOG4105CNW domain protein FOC93_RS11295 ENOG4105EMN RNA polymerase sigma factor FOC93_RS11300 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC93_RS11310 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC93_RS11330 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC93_RS11355 ENOG4105KBJ sporulation protein ytfj FOC93_RS11360 ENOG4105D7V transposase FOC93_RS11445 ENOG4108MGT Required for secretion of EsxA and EsxB FOC93_RS11480 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC93_RS11510 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC93_RS11515 ENOG4108JYZ YitT family FOC93_RS11520 ENOG41087PP glycosyltransferase MGT family FOC93_RS11535 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC93_RS11550 ENOG4108X4Q Hydrolase FOC93_RS11560 ENOG4108ZRV stage ii sporulation protein p FOC93_RS11590 ENOG4108VXD carboxy-peptidase FOC93_RS11600 ENOG4108ZRV stage ii sporulation protein p FOC93_RS11620 ENOG4108Z7R Chaperone CsaA FOC93_RS11640 ENOG4105C37 (CBS) domain FOC93_RS11645 ENOG4105SXS Protein of unknown function (DUF456) FOC93_RS11665 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC93_RS11675 ENOG4108S4H thioesterase Superfamily protein FOC93_RS11685 ENOG4108PJD permease FOC93_RS11700 ENOG4107T5V SNARE associated Golgi FOC93_RS11745 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC93_RS11755 ENOG4105K4T epimerase FOC93_RS11765 ENOG4105DSE periplasmic solute binding protein FOC93_RS11775 ENOG4105CKI cobalamin synthesis protein FOC93_RS11780 ENOG4107QM2 Aldo Keto reductase FOC93_RS11785 ENOG4105VMI -acetyltransferase FOC93_RS11800 ENOG4105DEN Luciferase family FOC93_RS11815 ENOG4108WPJ Ferritin-like domain FOC93_RS11820 ENOG4108K88 Membrane FOC93_RS11835 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_RS11860 ENOG4107XZQ multidrug resistance protein FOC93_RS11865 ENOG4105CPC Aldo Keto reductase FOC93_RS11870 ENOG4105YVS arsR family transcriptional regulator FOC93_RS11880 ENOG4105KRN Transcriptional regulator, abrb family FOC93_RS11930 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC93_RS11935 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC93_RS11945 ENOG4105YWU small acid-soluble spore protein FOC93_RS11950 ENOG4108WBH protein TIM barrel FOC93_RS11965 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_RS11970 ENOG4105DUU IucA IucC family protein FOC93_RS11985 ENOG4105KT7 mgtC SapB transporter FOC93_RS12000 ENOG4105BZU Histidine kinase FOC93_RS12005 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_RS12015 ENOG4108KGH TRANSCRIPTIONal FOC93_RS12030 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FOC93_RS12040 ENOG4105D6E homoserine dehydrogenase FOC93_RS12065 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC93_RS12075 ENOG4105BZU Histidine kinase FOC93_RS12080 ENOG4105EFI regulatoR FOC93_RS12085 ENOG4105BZ1 (ABC) transporter FOC93_RS12140 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC93_RS12150 ENOG4105K64 Glycosyl transferase, family 2 FOC93_RS12160 ENOG4108JJ8 (ABC) transporter FOC93_RS12165 ENOG4108JJ9 ABC, transporter FOC93_RS12170 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC93_RS12175 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC93_RS12195 ENOG4105SKE transcriptional Regulator LysR family FOC93_RS12205 ENOG4105C32 Amino acid ABC transporter (Permease) FOC93_RS12210 ENOG4108IV0 ABC, transporter FOC93_RS12215 ENOG4105C0Z ABC transporter FOC93_RS12225 ENOG4105CKI cobalamin synthesis protein FOC93_RS12240 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC93_RS12245 ENOG4106F5Q Membrane FOC93_RS12250 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC93_RS12255 ENOG4108TVJ Nitroreductase FOC93_RS12260 ENOG4107ZXU DSBA oxidoreductase FOC93_RS12265 ENOG4108Z40 Transcriptional regulator FOC93_RS12270 ENOG4105GZI Transcriptional regulator FOC93_RS12275 ENOG4107RT3 EamA-like transporter family FOC93_RS12280 ENOG4105KTB nuclear export factor GLE1 FOC93_RS12285 ENOG4108T5E Copper resistance protein FOC93_RS12325 ENOG4107R16 Multicopper oxidase FOC93_RS12335 ENOG4107RAQ aminopeptidase FOC93_RS12365 ENOG4108IBT Inherit from COG: transposase FOC93_RS12385 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC93_RS12390 ENOG4105D9N nucleoside FOC93_RS12400 ENOG4107RHR regulatoR FOC93_RS12415 ENOG4105K8R UPF0145 protein FOC93_RS12440 ENOG4105C0X amino acid FOC93_RS12445 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC93_RS12460 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC93_RS12480 ENOG41068WN FOC93_RS12500 ENOG4105K5X acetyltransferase FOC93_RS12505 ENOG4105CYC Transferase FOC93_RS12510 ENOG4105DY9 regulatoR FOC93_RS12520 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC93_RS12525 ENOG4105C6X Major Facilitator FOC93_RS12550 ENOG4105C7B Threonine dehydratase FOC93_RS12555 ENOG4105C01 Dihydroxy-acid dehydratase FOC93_RS12560 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC93_RS12570 ENOG4105C7K acetolactate synthase FOC93_RS12575 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC93_RS12580 ENOG4105CHR reductase FOC93_RS12585 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC93_RS12605 ENOG4105H67 Protein of unknown function (DUF421) FOC93_RS12610 ENOG4105X5K response regulator receiver protein FOC93_RS12615 ENOG4105C8J )-transporter FOC93_RS12635 ENOG4105C6T cysteine synthase FOC93_RS12640 ENOG4105EU0 Major facilitator Superfamily FOC93_RS12645 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC93_RS12655 ENOG4105DXI Major Facilitator superfamily FOC93_RS12665 ENOG4105U3E Transcriptional regulator FOC93_RS12670 ENOG4105CSR polyphosphate kinase 2 FOC93_RS12685 ENOG4105FVX FOC93_RS12735 ENOG4105C6K Malic enzyme FOC93_RS12740 ENOG4108IJ0 Aspartate ammonia-lyase FOC93_RS12750 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC93_RS12775 ENOG4105CJ1 ABC, transporter FOC93_RS12810 ENOG4106BRA Membrane FOC93_RS12870 ENOG4105C2M dna polymerase I FOC93_RS12895 ENOG4105K63 Thioredoxin FOC93_RS12935 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_RS13120 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC93_RS13145 ENOG4105EC3 peptidase S51, dipeptidase E FOC93_RS13150 ENOG4107QJQ Mate efflux family protein FOC93_RS13170 ENOG4105C9Q fumarate hydratase class II FOC93_RS13180 ENOG4105VUF Transcriptional regulator FOC93_RS13185 ENOG4105DFD Na H antiporter FOC93_RS13200 ENOG4108PJD permease FOC93_RS13205 ENOG4105CKI cobalamin synthesis protein FOC93_RS13215 ENOG4108UZ3 Transporter FOC93_RS13220 ENOG4105DRR Transcriptional regulator, GntR family FOC93_RS13230 ENOG4105PGM cation diffusion facilitator family transporter FOC93_RS13250 ENOG4105CAQ asparagine synthetase FOC93_RS13270 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FOC93_RS13280 ENOG4105CVJ phosphoglycerate mutase FOC93_RS13315 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC93_RS13320 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC93_RS13355 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC93_RS13390 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC93_RS13395 ENOG4105KTQ flagellar basal-body rod protein FOC93_RS13400 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC93_RS13405 ENOG4105D7B Flagellar biosynthesis protein flha FOC93_RS13410 ENOG4105D00 flagellar biosynthetic protein flhB FOC93_RS13420 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC93_RS13425 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC93_RS13435 ENOG4105DD5 Flagellar motor switch protein FOC93_RS13440 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC93_RS13450 ENOG4105E4C Lytic transglycosylase catalytic FOC93_RS13455 ENOG4105I03 Flagellin FOC93_RS13460 ENOG4105I03 Flagellin FOC93_RS13470 ENOG4107R88 Chemotaxis protein (CheV) FOC93_RS13485 ENOG4105BZE flagellar hook protein, FlgE FOC93_RS13515 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC93_RS13520 ENOG4107U2N Flagellar M-ring protein FOC93_RS13530 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC93_RS13535 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC93_RS13550 ENOG4105DTS flagellar hook-associated FOC93_RS13555 ENOG4105DTJ flagellar hook-associated protein FOC93_RS13560 ENOG4105E1Q flagellar hook-associated protein FOC93_RS13580 ENOG4105BZU Histidine kinase FOC93_RS13595 ENOG4105DD5 Flagellar motor switch protein FOC93_RS13600 ENOG4105CBS Chea signal transduction histidine kinase FOC93_RS13605 ENOG4107YTP response regulator receiver protein FOC93_RS13610 ENOG4105ER2 Ompa motb domain protein FOC93_RS13615 ENOG4107R0U MotA TolQ exbB proton channel FOC93_RS13625 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC93_RS13665 ENOG41080C8 DUF218 domain FOC93_RS13670 ENOG4105H67 Protein of unknown function (DUF421) FOC93_RS13680 ENOG4108Z5V transcriptional regulator, merr family FOC93_RS13685 ENOG4105CN5 Metallo-Beta-Lactamase FOC93_RS13690 ENOG4107RWR Sodium hydrogen exchanger FOC93_RS13700 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC93_RS13765 ENOG41081VK Ribonuclease FOC93_RS13785 ENOG4108SZE gCN5-related N-acetyltransferase FOC93_RS13800 ENOG4105CPK Glycosyl transferase (Group 1 FOC93_RS13830 ENOG4105HTX biosynthesis protein FOC93_RS13885 ENOG4105KHC sulfurtransferase FOC93_RS13895 ENOG4108W0I acetyltransferase FOC93_RS13905 ENOG410890F Dynamin family FOC93_RS13915 ENOG4105DHF Membrane FOC93_RS13920 ENOG4105C2W permease FOC93_RS13930 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC93_RS13940 ENOG4105CTD carboxy-peptidase FOC93_RS13945 ENOG4105DVT helicase FOC93_RS13955 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC93_RS14010 ENOG4105BZ4 penicillin-binding protein FOC93_RS14020 ENOG4105CSM endonuclease III FOC93_RS14040 ENOG4105YAC FOC93_RS14045 ENOG4105DVT helicase FOC93_RS14060 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FOC93_RS14080 ENOG4105CPK Glycosyl transferase (Group 1 FOC93_RS14085 ENOG4105FJR Lmbe family FOC93_RS14100 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC93_RS14105 ENOG4108JYZ YitT family FOC93_RS14140 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC93_RS14145 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC93_RS14160 ENOG41068YB TPR repeat-containing protein FOC93_RS14175 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC93_RS14180 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FOC93_RS14185 ENOG4105EAH synthase FOC93_RS14195 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC93_RS14210 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC93_RS14240 ENOG41065D1 FOC93_RS14245 ENOG4105S2F FOC93_RS14260 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FOC93_RS14280 ENOG4107RB3 L-asparaginase FOC93_RS14285 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC93_RS14310 ENOG4108S6Z Negative regulator of genetic competence FOC93_RS14315 ENOG4108XDN Transcriptional regulator FOC93_RS14320 ENOG4107RGJ metallophosphoesterase FOC93_RS14330 ENOG4105I7S Abortive infection protein FOC93_RS14335 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC93_RS14350 ENOG4108SAX Membrane FOC93_RS14365 ENOG4108WBT adenosyltransferase FOC93_RS14370 ENOG4105BZU Histidine kinase FOC93_RS14375 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS14380 ENOG4105CRE cytochrome C FOC93_RS14385 ENOG4107TWT Cytochrome c biogenesis protein FOC93_RS14390 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC93_RS14395 ENOG4105FE9 pseudouridine synthase FOC93_RS14405 ENOG4108JIC nucleoside recognition domain protein FOC93_RS14410 ENOG4105DZ1 carboxypeptidase FOC93_RS14415 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC93_RS14445 ENOG4105BZU Histidine kinase FOC93_RS14460 ENOG4105I3N Conserved Protein FOC93_RS14465 ENOG4105BZU Histidine kinase FOC93_RS14480 ENOG4105BZ4 penicillin-binding protein FOC93_RS14485 ENOG4107GRR phosphate transport regulator FOC93_RS14490 ENOG4105CJ3 phosphate transporter FOC93_RS14510 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC93_RS14535 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC93_RS14555 ENOG4105WH1 Two component transcriptional regulator luxr family FOC93_RS14560 ENOG4105ENE Histidine kinase FOC93_RS14580 ENOG4105DFD Na H antiporter FOC93_RS14610 ENOG4105C8J )-transporter FOC93_RS14615 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC93_RS14620 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC93_RS14625 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC93_RS14635 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC93_RS14640 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC93_RS14645 ENOG4107S4M Sulfate adenylate transferase FOC93_RS14660 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC93_RS14670 ENOG4105E0M Sulfatase FOC93_RS14675 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC93_RS14690 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC93_RS14705 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FOC93_RS14710 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FOC93_RS14715 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOC93_RS14720 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOC93_RS14725 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC93_RS14730 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOC93_RS14745 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC93_RS14760 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC93_RS14765 ENOG4108ZP8 Acetolactate synthase small subunit FOC93_RS14770 ENOG4105C7K acetolactate synthase FOC93_RS14775 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC93_RS14795 ENOG4105KBJ sporulation protein ytfj FOC93_RS14800 ENOG41063Y9 FOC93_RS14805 ENOG4105CZN Potassium uptake protein FOC93_RS14875 ENOG4105NQC Flavodoxin FOC93_RS14900 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC93_RS14910 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC93_RS14915 ENOG4105EA8 2-Nitropropane dioxygenase FOC93_RS14920 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC93_RS14960 ENOG4105CJ1 ABC, transporter FOC93_RS14970 ENOG4105CZV ABC transporter FOC93_RS14975 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC93_RS14980 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC93_RS14985 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC93_RS14990 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC93_RS15025 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC93_RS15030 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC93_RS15035 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FOC93_RS15040 ENOG4105BZU Histidine kinase FOC93_RS15045 ENOG4106DF1 FOC93_RS15055 ENOG41090MY MarR family Transcriptional regulator FOC93_RS15060 ENOG4105BZU Histidine kinase FOC93_RS15070 ENOG4105PXI polysaccharide deacetylase FOC93_RS15080 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC93_RS15090 ENOG4105E98 transcriptional regulator DeoR family FOC93_RS15110 ENOG4107RCV ABC transporter, permease FOC93_RS15115 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC93_RS15120 ENOG4105C4Y ABC transporter FOC93_RS15150 ENOG4105CHR reductase FOC93_RS15170 ENOG4108Z7G MaoC domain protein dehydratase FOC93_RS15175 ENOG410681C small acid-soluble spore protein FOC93_RS15180 ENOG4105CZN Potassium uptake protein FOC93_RS15185 ENOG4107TS3 membrane protein, TerC FOC93_RS15190 ENOG4108QTI )-transporter FOC93_RS15200 ENOG4106A3R peptidase FOC93_RS15220 ENOG4105JXH GntR family transcriptional regulator FOC93_RS15225 ENOG4105BZU Histidine kinase FOC93_RS15230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS15245 ENOG4105CQB FAD linked oxidase domain protein FOC93_RS15250 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC93_RS15255 ENOG4105K4I Scp-like extracellular FOC93_RS15265 ENOG4108YBP pseudouridine synthase FOC93_RS15275 ENOG4105EYF MMPL domain protein FOC93_RS15285 ENOG4108HM4 ABC transporter FOC93_RS15290 ENOG4105D38 putrescine abc transporter FOC93_RS15295 ENOG4105F38 ABC transporter, permease FOC93_RS15300 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC93_RS15305 ENOG4105C26 Dehydrogenase FOC93_RS15340 ENOG4105VFR signal peptidase FOC93_RS15345 ENOG4105DZ1 carboxypeptidase FOC93_RS15370 ENOG4105RHA ABC transporter, permease FOC93_RS15375 ENOG4108IUX (ABC) transporter FOC93_RS15410 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FOC93_RS15415 ENOG4105C7S Dehydrogenase FOC93_RS15435 ENOG41089UC methyltransferase, type 11 FOC93_RS15505 ENOG4105DK0 Indole-3-glycerol phosphate synthase FOC93_RS15515 ENOG4105DDQ anthranilate synthase FOC93_RS15525 ENOG4105CK7 Sodium proline symporter FOC93_RS15600 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC93_RS15610 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC93_RS15615 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC93_RS15635 ENOG4107TVC Glycosyl transferase, family 2 FOC93_RS15655 ENOG4105K64 Glycosyl transferase, family 2 FOC93_RS15675 ENOG4105EMS pseudouridine synthase FOC93_RS15680 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC93_RS15695 ENOG4105MIX Adenylate cyclase FOC93_RS15700 ENOG4108Z18 K06886 hemoglobin FOC93_RS15715 ENOG4105DPN Oligoendopeptidase f FOC93_RS15725 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC93_RS15735 ENOG4108ZCF integral membrane protein FOC93_RS15755 ENOG4105UQX Mate efflux family protein FOC93_RS15760 ENOG4108JQ7 (ABC) transporter FOC93_RS15770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC93_RS15775 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC93_RS15790 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC93_RS15805 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC93_RS15810 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC93_RS15835 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC93_RS15845 ENOG4108KP7 hydrolase FOC93_RS15855 ENOG41073B9 FOC93_RS15860 ENOG4107AYK membrAne FOC93_RS15870 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC93_RS15875 ENOG4105QNR S1 RNA binding domain protein FOC93_RS15895 ENOG4105BZU Histidine kinase FOC93_RS15900 ENOG4105CH6 catalase FOC93_RS15905 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC93_RS15910 ENOG4105CAQ asparagine synthetase FOC93_RS15925 ENOG4105C8Y Acetylornithine aminotransferase FOC93_RS15935 ENOG4105ERH Fumarylacetoacetate hydrolase FOC93_RS16035 ENOG4107QP3 malate synthase g FOC93_RS16045 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FOC93_RS16050 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_RS16055 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC93_RS16075 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_RS16090 ENOG41086D8 Transcriptional regulator FOC93_RS16095 ENOG4108AEY RNA polymerase sigma factor FOC93_RS16105 ENOG4107TVP HD domain protein FOC93_RS16110 ENOG4107RN3 metallophosphoesterase FOC93_RS16125 ENOG4108IJ6 ABC transporter FOC93_RS16130 ENOG4105ECW sulfate abc transporter FOC93_RS16135 ENOG4108I5D sulfate abc transporter FOC93_RS16140 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FOC93_RS16150 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_RS16160 ENOG4105DF9 Lipoate-protein, ligase FOC93_RS16165 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC93_RS16170 ENOG4106AXD FOC93_RS16200 ENOG4105ECB domain protein FOC93_RS16200 ENOG4105ECB domain protein FOC93_RS16215 ENOG4105NA0 Transcriptional regulator FOC93_RS16240 ENOG4105C1Q protoporphyrinogen oxidase FOC93_RS16245 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC93_RS16255 ENOG4105BZ4 penicillin-binding protein FOC93_RS16260 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC93_RS16270 ENOG410905X membrane-flanked domain protein FOC93_RS16310 ENOG4105CKV Membrane FOC93_RS16315 ENOG410905X membrane-flanked domain protein FOC93_RS16350 ENOG4105K59 histidine triad (HIT) protein FOC93_RS16375 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC93_RS16380 ENOG4105EEM helicase FOC93_RS16385 ENOG4105CNI cell division protein FtsW FOC93_RS16395 ENOG4105DU6 RNA polymerase FOC93_RS16415 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC93_RS16430 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC93_RS16440 ENOG4105F0F Oxalate decarboxylase FOC93_RS16460 ENOG4108MUZ hydrolase FOC93_RS16495 ENOG4105ED2 Beta-lactamase FOC93_RS16505 ENOG4106D4I domain protein FOC93_RS16510 ENOG4107VRP DNA repair exonuclease FOC93_RS16530 ENOG4107QHE Choloylglycine hydrolase FOC93_RS16540 ENOG4105D7V transposase FOC93_RS16580 ENOG4105BZU Histidine kinase FOC93_RS16585 ENOG4105BZU Histidine kinase FOC93_RS16590 ENOG4108MJI response regulator FOC93_RS16600 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_RS16610 ENOG4105WN5 stage II sporulation protein FOC93_RS16705 ENOG4105CMT Dihydroxyacetone kinase FOC93_RS16715 ENOG4105CMT Dihydroxyacetone kinase FOC93_RS16720 ENOG4108NIW Leucine export protein LeuE FOC93_RS16735 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC93_RS16785 ENOG4105F6J Alpha beta hydrolase fold FOC93_RS16840 ENOG4105D9U N-acetyltransferase FOC93_RS16860 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_RS16880 ENOG4108Z86 Glutamine amidotransferase FOC93_RS16905 ENOG4105CDU Replicative dna helicase FOC93_RS16950 ENOG4107SCJ type I restriction enzyme EcoKI subunit R FOC93_RS16970 ENOG4108MRH transcriptional regulatory protein FOC93_RS16980 ENOG4105CSH Transporter FOC93_RS17035 ENOG4108IBT Inherit from COG: transposase FOC93_RS17095 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FOC93_RS17110 ENOG4108JQ7 (ABC) transporter FOC93_RS17120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC93_RS17165 ENOG4105DER m42 family FOC93_RS17185 ENOG4105CGU Enoyl-CoA hydratase FOC93_RS17210 ENOG4105CHH sulfate transporter FOC93_RS17225 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_RS17230 ENOG4105D4P Coproporphyrinogen iii oxidase FOC93_RS17235 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC93_RS17250 ENOG4108VX5 3-methyladenine DNA glycosylase FOC93_RS17260 ENOG4107FQX Alpha-acetolactate decarboxylase FOC93_RS17310 ENOG4105WH1 Two component transcriptional regulator luxr family FOC93_RS17315 ENOG4105BZU Histidine kinase FOC93_RS17330 ENOG4108UH6 UPF0754 membrane protein FOC93_RS17340 ENOG410839P FOC93_RS17355 ENOG4105CDA abc transporter atp-binding protein FOC93_RS17360 ENOG4105DRP amino acid AbC transporter FOC93_RS17370 ENOG4105BZ1 (ABC) transporter FOC93_RS17375 ENOG4105BZ1 (ABC) transporter FOC93_RS17380 ENOG4105C26 Dehydrogenase FOC93_RS17390 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC93_RS17395 ENOG4105D5Q Arginine ornithine antiporter FOC93_RS17405 ENOG4105CH6 catalase FOC93_RS17410 ENOG4107RKG DJ-1/PfpI family FOC93_RS17425 ENOG4105E5W Transporter FOC93_RS17430 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC93_RS17475 ENOG4105UBK short-chain dehydrogenase reductase FOC93_RS17480 ENOG4105CH7 arginosuccinase FOC93_RS17485 ENOG4108YXU transcriptional regulator AsnC family FOC93_RS17525 ENOG4106KNT transcriptional regulator FOC93_RS17535 ENOG4107RWR Sodium hydrogen exchanger FOC93_RS17540 ENOG4105CUB amino acid FOC93_RS17575 ENOG4107T5V SNARE associated Golgi FOC93_RS17610 ENOG4105WEF catalase FOC93_RS17640 ENOG4105C19 ABC transporter FOC93_RS17645 ENOG4107RBB ABC transporter, permease FOC93_RS17650 ENOG41069ER domain protein FOC93_RS17675 ENOG4105VZJ PTS System FOC93_RS17680 ENOG4105VCP PTS System FOC93_RS17685 ENOG4105EMD TRANSCRIPTIONal FOC93_RS17710 ENOG4108KGH TRANSCRIPTIONal FOC93_RS17720 ENOG41087NI Sulfite exporter TauE/SafE FOC93_RS17725 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC93_RS17735 ENOG4105VFE sira family FOC93_RS17740 ENOG4105VFE sira family FOC93_RS17745 ENOG4107TPS domain protein FOC93_RS17750 ENOG4105VFE sira family FOC93_RS17755 ENOG4105XTG Pfam:DUF156 FOC93_RS17760 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC93_RS17765 ENOG4108TCS Glutamyl endopeptidase FOC93_RS17775 ENOG4105ED1 spovr family FOC93_RS17780 ENOG4107Y03 Nitroreductase FOC93_RS17800 ENOG4108B31 Spore germination protein FOC93_RS17820 ENOG4105K63 Thioredoxin FOC93_RS17835 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC93_RS17845 ENOG4105C7N Xanthine uracil vitamin C permease FOC93_RS17855 ENOG4105C19 ABC transporter FOC93_RS17880 ENOG4108INS Transcriptional regulator FOC93_RS17930 ENOG4105DWF phosphomethylpyrimidine kinase FOC93_RS17935 ENOG4105D06 uba thif-type nad fad binding protein FOC93_RS17950 ENOG41080HI glycine oxidase FOC93_RS17955 ENOG4108VEU Thiamine monophosphate synthase FOC93_RS17965 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC93_RS17975 ENOG4105ETU transcriptional activator (TenA FOC93_RS17995 ENOG41080XQ Signal transduction protein with cbs domains FOC93_RS18125 ENOG4105C8U phosphate abc transporter FOC93_RS18130 ENOG4105CVA phosphate FOC93_RS18135 ENOG4105CE1 Ferrous iron transport protein b FOC93_RS18140 ENOG4105CE1 Ferrous iron transport protein b FOC93_RS18145 ENOG4105CE1 Ferrous iron transport protein b FOC93_RS18155 ENOG4108NHD germination protein FOC93_RS18170 ENOG4105E1V na solute symporter FOC93_RS18195 ENOG4105E2S oxidase) subunit II FOC93_RS18200 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC93_RS18205 ENOG4105CCU oxidase (Subunit III) FOC93_RS18225 ENOG4105MA6 gCN5-related N-acetyltransferase FOC93_RS18240 ENOG4105C7N Xanthine uracil vitamin C permease FOC93_RS18245 ENOG4105C85 amino acid FOC93_RS18265 ENOG4105DUX Transporter FOC93_RS18280 ENOG4107D63 FOC93_RS18285 ENOG4105VZ8 Transcriptional regulator FOC93_RS18290 ENOG41069ER domain protein FOC93_RS18295 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC93_RS18300 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC93_RS18330 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FOC93_RS18370 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC93_RS18375 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC93_RS18380 ENOG4105CNN ABC, transporter FOC93_RS18385 ENOG4105C2J ABC transporter FOC93_RS18395 ENOG4108RVA ribokinase FOC93_RS18400 ENOG4105ETE Transcriptional regulator (LacI family FOC93_RS18405 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_RS18410 ENOG41067TZ transcriptional regulator, MarR family FOC93_RS18415 ENOG4105CXY transporter FOC93_RS18425 ENOG41068KF Universal stress protein FOC93_RS18430 ENOG4105CHH sulfate transporter FOC93_RS18440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS18445 ENOG4105BZU Histidine kinase FOC93_RS18450 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC93_RS18455 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC93_RS18465 ENOG4105GFR rna polymerase sigma factor FOC93_RS18480 ENOG4108IQI permease FOC93_RS18485 ENOG4105DRP amino acid AbC transporter FOC93_RS18490 ENOG4105EAD ABC transporter FOC93_RS18495 ENOG4105CT1 (ABC) transporter FOC93_RS18500 ENOG4105CDA abc transporter atp-binding protein FOC93_RS18510 ENOG4105CRN Aminoglycoside phosphotransferase FOC93_RS18515 ENOG4105E1K spore germination protein FOC93_RS18530 ENOG4105CG3 alpha amylase, catalytic region FOC93_RS18535 ENOG4105C5Y PTS System FOC93_RS18540 ENOG4107414 GntR family transcriptional regulator FOC93_RS18545 ENOG4105D5Q Arginine ornithine antiporter FOC93_RS18555 ENOG4105BZU Histidine kinase FOC93_RS18565 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC93_RS18570 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC93_RS18575 ENOG4107T89 von Willebrand factor, type A FOC93_RS18585 ENOG4105EXW epimerase dehydratase FOC93_RS18590 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC93_RS18595 ENOG4105DMQ Methyltransferase FOC93_RS18600 ENOG4105E0A ABC, transporter FOC93_RS18605 ENOG4108IHU transport system permease protein FOC93_RS18610 ENOG4105DQ5 transport system permease protein FOC93_RS18615 ENOG4108MES Periplasmic binding protein FOC93_RS18620 ENOG4105DUX Transporter FOC93_RS18635 ENOG4105DAA L-lactate FOC93_RS18640 ENOG4108IJ0 Aspartate ammonia-lyase FOC93_RS18645 ENOG4105C37 (CBS) domain FOC93_RS18650 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC93_RS18655 ENOG4105D9N nucleoside FOC93_RS18660 ENOG4108KGH TRANSCRIPTIONal FOC93_RS18665 ENOG41073R8 VanW family FOC93_RS18700 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC93_RS18705 ENOG4105C59 p-type ATPase FOC93_RS18720 ENOG4105CUB amino acid FOC93_RS18740 ENOG4108JB9 formate dehydrogenase FOC93_RS18745 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC93_RS18750 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC93_RS18755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS18760 ENOG4105BZU Histidine kinase FOC93_RS18770 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC93_RS18775 ENOG4108UZ3 Transporter FOC93_RS18785 ENOG4105C6K Malic enzyme FOC93_RS18795 ENOG4108MRH transcriptional regulatory protein FOC93_RS18820 ENOG41062D9 Histidine kinase FOC93_RS18825 ENOG4108STX response regulator FOC93_RS18830 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC93_RS18835 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC93_RS18840 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC93_RS18845 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC93_RS18850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC93_RS18855 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC93_RS18880 ENOG4105D4T Citrate transporter FOC93_RS18885 ENOG4108V9W transcriptional regulatory protein FOC93_RS18890 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC93_RS18900 ENOG4105DZ6 Band 7 protein FOC93_RS18915 ENOG4105C94 Transporter FOC93_RS18935 ENOG4105CYN Serine protein kinase FOC93_RS18945 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC93_RS18955 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC93_RS18965 ENOG4108R9S DSBA oxidoreductase FOC93_RS18970 ENOG4108JQC penicillin-binding protein 1A FOC93_RS19090 ENOG4105G5W regulator Fur family FOC93_RS19095 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC93_RS19115 ENOG4108IUW ABC transporter FOC93_RS19125 ENOG4105CBC glutamate synthase FOC93_RS19130 ENOG4107NBY Membrane FOC93_RS19135 ENOG4105BZ1 (ABC) transporter FOC93_RS19155 ENOG4106BXE FOC93_RS19160 ENOG4105CEN a g-specific adenine glycosylase FOC93_RS19165 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC93_RS19195 ENOG4105ECP epimerase FOC93_RS19200 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC93_RS19215 ENOG4108QBV Monogalactosyldiacylglycerol synthase FOC93_RS19220 ENOG4105F1A Pyruvate formate-lyase FOC93_RS19240 ENOG4105C3I Nad-dependent epimerase dehydratase FOC93_RS19245 ENOG4107QQG Dehydrogenase FOC93_RS19250 ENOG4105CKK Glycosyl transferase, family 2 FOC93_RS19265 ENOG4108A04 Beta-lactamase FOC93_RS19305 ENOG4108IQI permease FOC93_RS19315 ENOG4108JUB Transcriptional regulator FOC93_RS19325 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC93_RS19330 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC93_RS19365 ENOG4105UPD Calcium Proton FOC93_RS19370 ENOG410606W general stress protein FOC93_RS19385 ENOG4107ZTW SNARE associated Golgi FOC93_RS19405 ENOG4108IPJ Membrane FOC93_RS19410 ENOG4105C59 p-type ATPase FOC93_RS19415 ENOG4107U9T Pfam:Ribonuclease_BN FOC93_RS19425 ENOG4105KJF protein tyrosine phosphatase FOC93_RS19445 ENOG4108TTB tellurium resistance protein FOC93_RS19450 ENOG4107TS3 membrane protein, TerC FOC93_RS19455 ENOG4106FN3 tellurium resistance protein FOC93_RS19460 ENOG4106FN3 tellurium resistance protein FOC93_RS19465 ENOG4108N0M stress protein FOC93_RS19480 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FOC93_RS19495 ENOG4105DEU major facilitator superfamily FOC93_RS19510 ENOG41062JF Transcriptional regulator FOC93_RS19550 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC93_RS19570 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC93_RS19585 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC93_RS19600 ENOG4105CI1 PTS System FOC93_RS19610 ENOG4105DNP FAD linked oxidase domain protein FOC93_RS19620 ENOG4108W63 CRP FNR family transcriptional regulator FOC93_RS19625 ENOG4105C5B carbamate kinase FOC93_RS19635 ENOG4105DBV ornithine carbamoyltransferase FOC93_RS19650 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_RS19660 ENOG4105EAB amino acid AbC transporter FOC93_RS19665 ENOG4105E5Q amino acid AbC transporter FOC93_RS19680 ENOG4105D2S major facilitator superfamily FOC93_RS19685 ENOG410756H nucleotidyltransferase FOC93_RS19705 ENOG4105BZU Histidine kinase FOC93_RS19720 ENOG4106UIA FOC93_RS19725 ENOG4106UIA FOC93_RS19745 ENOG4108V5C ABC transporter FOC93_RS19750 ENOG4105DQ5 transport system permease protein FOC93_RS19755 ENOG4105EHG Permease protein FOC93_RS19775 ENOG4105D3R alkyl hydroperoxide reductase FOC93_RS19795 ENOG4105DFD Na H antiporter FOC93_RS19805 ENOG4105DTQ mandelate racemase muconate lactonizing FOC93_RS19820 ENOG4108W15 Protein of unknown function (DUF1456) FOC93_RS19840 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC93_RS19845 ENOG4105D9N nucleoside FOC93_RS19875 ENOG4105KPY Small multidrug resistance protein FOC93_RS19880 ENOG4105C26 Dehydrogenase FOC93_RS19890 ENOG4108JPW Aminotransferase FOC93_RS19895 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC93_RS19900 ENOG4105CBD Diacylglycerol kinase FOC93_RS19920 ENOG4107I77 yiaA/B two helix domain FOC93_RS19925 ENOG410834F Transcriptional regulator FOC93_RS19945 ENOG4105D01 (LipO)protein FOC93_RS19950 ENOG4108UMI ABC transporter, permease FOC93_RS19955 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC93_RS19960 ENOG4108W2Y isochorismatase FOC93_RS19980 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOC93_RS19985 ENOG4105C4R Atp-dependent dna helicase FOC93_RS20010 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC93_RS20020 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC93_RS20045 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC93_RS20055 ENOG4105C83 adenylosuccinate lyase FOC93_RS20060 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC93_RS20065 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC93_RS20090 ENOG4105SX7 Transporter FOC93_RS20110 ENOG4108SHN Glycosyl transferase, family 2 FOC93_RS20120 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FOC93_RS20160 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_RS20205 ENOG4107ZXU DSBA oxidoreductase FOC93_RS20230 ENOG4105BZU Histidine kinase FOC93_RS20240 ENOG4105C7N Xanthine uracil vitamin C permease FOC93_RS20260 ENOG4108TYN CAAX amino terminal protease family protein FOC93_RS20275 ENOG4105C5H ABC transporter FOC93_RS20280 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC93_RS20285 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC93_RS20290 ENOG41072GX Peptidase M22 Glycoprotease FOC93_RS20295 ENOG4105K8N protein family UPF0079, ATPase FOC93_RS20400 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC93_RS20410 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC93_RS20415 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC93_RS20440 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC93_RS20445 ENOG4105CPF Cell wall formation (By similarity) FOC93_RS20450 ENOG4108SC4 )-transporter FOC93_RS20455 ENOG4105CUB amino acid FOC93_RS20465 ENOG4105ERH Fumarylacetoacetate hydrolase FOC93_RS20470 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC93_RS20500 ENOG410667J hydrolase FOC93_RS20505 ENOG4108JQ7 (ABC) transporter FOC93_RS20510 ENOG4105C3U ABC transporter FOC93_RS20515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC93_RS20525 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC93_RS20535 ENOG4105C5H ABC transporter FOC93_RS20555 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC93_RS20570 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC93_RS20590 ENOG4105F6E Acyl-transferase FOC93_RS20610 ENOG4105EGI Transcriptional regulator FOC93_RS20620 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC93_RS20625 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC93_RS20630 ENOG4105E0C molybdate abc transporter FOC93_RS20650 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC93_RS20655 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC93_RS20685 ENOG4108JQ7 (ABC) transporter FOC93_RS20690 ENOG4105C3U ABC transporter FOC93_RS20695 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC93_RS20700 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC93_RS20715 ENOG4105C2C drug resistance transporter, Bcr CflA FOC93_RS20730 ENOG4105IQ5 FAD linked oxidase domain protein FOC93_RS20740 ENOG4105CB2 alcohol dehydrogenase FOC93_RS20745 ENOG4105D01 (LipO)protein FOC93_RS20750 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC93_RS20755 ENOG4108UMI ABC transporter, permease FOC93_RS20760 ENOG4108PSK reductase FOC93_RS20785 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC93_RS20800 ENOG4107U5W ybbr family FOC93_RS20805 ENOG4105C8B TIGR00159 family FOC93_RS20885 ENOG4108NMV polysaccharide deacetylase FOC93_RS20900 ENOG4105D1F ATP-binding protein FOC93_RS20925 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC93_RS20930 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC93_RS20935 ENOG4108JJB ABC transporter FOC93_RS20940 ENOG4108JJB ABC transporter FOC93_RS20975 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC93_RS20985 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC93_RS21115 ENOG4105XPM ribosomal protein FOC93_RS21130 ENOG4107Y49 methyltransferase FOC93_RS21155 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC93_RS21170 ENOG4105QIV RNA polymerase FOC93_RS21175 ENOG4105M0M Tetracycline resistance protein FOC93_RS21180 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC93_RS21195 ENOG4105D7W serine acetyltransferase FOC93_RS21210 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOC93_RS21215 ENOG4105CTP PilT protein domain protein FOC93_RS21225 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC93_RS21240 ENOG4108Z0C Uvrb UvrC protein FOC93_RS21330 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC93_RS21340 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC93_RS21345 ENOG4105KRF dihydroneopterin aldolase FOC93_RS21350 ENOG4105EEI dihydropteroate synthase FOC93_RS21355 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC93_RS21360 ENOG4105DDQ anthranilate synthase FOC93_RS21365 ENOG4105CRQ synthase (Component I) FOC93_RS21370 ENOG4105C6T cysteine synthase FOC93_RS21385 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC93_RS21390 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC93_RS21395 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC93_RS21415 ENOG41060GV RNA binding s1 domain protein FOC93_RS21430 ENOG4105VYY sporulation protein yabp FOC93_RS21435 ENOG41082I2 s4 domain protein FOC93_RS21440 ENOG4108IY2 MazG family FOC93_RS21450 ENOG4108M14 stage v sporulation protein t FOC93_RS21455 ENOG4108JA2 transcriptioN-repair coupling factor FOC93_RS21465 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC93_RS21485 ENOG4105KME endoribonuclease L-psp FOC93_RS21490 ENOG4105DFT pur operon repressor FOC93_RS21505 ENOG4105W42 Veg protein FOC93_RS21510 ENOG4105XFA sporulation peptidase YabG FOC93_RS21520 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC93_RS21525 ENOG4105F8V Hydrolase, tatD family FOC93_RS21530 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC93_RS21535 ENOG4105KRN Transcriptional regulator, abrb family FOC93_RS21540 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC93_RS21550 ENOG41060K3 Methyltransferase FOC93_RS21560 ENOG4105MA4 psp1 domain protein FOC93_RS21565 ENOG4105FA2 dna polymerase iii FOC93_RS21575 ENOG4105CXN decarboxylase FOC93_RS21610 ENOG41067KS pro-sigma K processing FOC93_RS21630 ENOG4105C6E dna polymerase iii FOC93_RS21640 ENOG4108Z6B deaminase FOC93_RS21645 ENOG4105GTG Isochorismatase FOC93_RS21655 ENOG4105ZMH deoxynucleoside kinase FOC93_RS21690 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC93_RS21725 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC93_RS21740 ENOG410848D S4 domain protein YaaA FOC93_RS21745 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC93_RS21765 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC93_RS21775 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC93_RS21795 ENOG4107QJE Chromosome Partitioning Protein FOC93_RS21800 ENOG4105FA0 parb-like partition protein FOC93_RS21805 ENOG4108ZDA Sporulation protein YyaC FOC93_RS21810 ENOG4105D8X mechanosensitive ion channel FOC93_RS21815 ENOG4105VDK protein, conserved in bacteria FOC93_RS21820 ENOG4105C3G gtp-binding protein FOC93_RS21830 ENOG4108UUM single-stranded DNA-binding protein FOC93_RS21840 ENOG4108XMW Membrane FOC93_RS21845 ENOG4105BZR domain protein FOC93_RS21855 ENOG4105CDU Replicative dna helicase FOC93_RS21860 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOC93_RS21885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS21890 ENOG4105BZU Histidine kinase FOC93_RS21905 ENOG4105Q2H domain protein FOC93_RS21910 ENOG4105C0H protease FOC93_RS21925 ENOG4105BZU Histidine kinase FOC93_RS21945 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FOC93_RS21950 ENOG4105C1J atp-dependent rna helicase FOC93_RS21960 ENOG4108UT2 hemolysin iii FOC93_RS21965 ENOG4105CMR udp-glucose 4-epimerase FOC93_RS21970 ENOG4105IW1 AmiS UreI transporter FOC93_RS21980 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC93_RS21995 ENOG4107RGD Major Facilitator superfamily FOC93_RS22000 ENOG4108HRK Histidine kinase FOC93_RS22005 ENOG4108NEV two component transcriptional regulator, LytTR family FOC93_RS22020 ENOG4106F5Q Membrane FOC93_RS22025 ENOG4105E0X reductase FOC93_RS22035 ENOG41067SE Tetr family transcriptional regulator FOC93_RS22040 ENOG4105C5H ABC transporter FOC93_RS22045 ENOG4105CKK Glycosyl transferase, family 2 FOC93_RS22050 ENOG4105EJV Membrane FOC93_RS22060 ENOG4105K64 Glycosyl transferase, family 2 FOC93_RS22075 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FOC93_RS22080 ENOG4108S4H thioesterase Superfamily protein FOC93_RS22090 ENOG4106YBV Methyl-accepting chemotaxis FOC93_RS22095 ENOG4105EN6 Membrane FOC93_RS22105 ENOG4105CG5 Glycosyl transferase (Group 1 FOC93_RS22115 ENOG41079KZ Major Facilitator Superfamily FOC93_RS22120 ENOG4105DY9 regulatoR FOC93_RS22125 ENOG4105D22 carbon starvation protein FOC93_RS22130 ENOG4105VCD cytoplasmic protein FOC93_RS22135 ENOG4105BZU Histidine kinase FOC93_RS22140 ENOG4105DWF phosphomethylpyrimidine kinase FOC93_RS22145 ENOG4105BZU Histidine kinase FOC93_RS22150 ENOG4105WH1 Two component transcriptional regulator luxr family FOC93_RS22160 ENOG4108Y4K DNA-binding transcriptional activator FOC93_RS22185 ENOG4105D6E homoserine dehydrogenase FOC93_RS22200 ENOG41090WU lipolytic protein G-D-S-L family FOC93_RS22205 ENOG4105CJ1 ABC, transporter FOC93_RS22210 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC93_RS22220 ENOG4105VCH membrane FOC93_RS22225 ENOG410667J hydrolase FOC93_RS22235 ENOG4107SVH Potassium channel protein FOC93_RS22255 ENOG4108VKI Cell wall hydrolase FOC93_RS22270 ENOG4108IJ2 phosphate acetyltransferase FOC93_RS22275 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FOC93_RS22280 ENOG4108VCI transcription factor, rsfa family FOC93_RS22290 ENOG4105DQ5 transport system permease protein FOC93_RS22295 ENOG4105EHG Permease protein FOC93_RS22300 ENOG4105E0A ABC, transporter FOC93_RS22305 ENOG4108MES Periplasmic binding protein FOC93_RS22310 ENOG4105DCI Phosphohydrolase FOC93_RS22315 ENOG41069HH 4-oxalocrotonate tautomerase FOC93_RS22320 ENOG4108Z4T Peptidase M50 FOC93_RS22325 ENOG4108XFG YwhD family FOC93_RS22330 ENOG4105BZ4 penicillin-binding protein FOC93_RS22335 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC93_RS22340 ENOG4107SWG transcriptional regulator MERR family FOC93_RS22345 ENOG4105DXB Major Facilitator superfamily FOC93_RS22355 ENOG4105CYW agmatinase FOC93_RS22375 ENOG410684U Domain of unknown function (DUF1934) FOC93_RS22385 ENOG4105JVQ RNA Polymerase FOC93_RS22405 ENOG4105IIU Aminopeptidase FOC93_RS22415 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC93_RS22420 ENOG4108M15 ABC transporter FOC93_RS22425 ENOG4105KCT ABC transporter FOC93_RS22430 ENOG4105BZU Histidine kinase FOC93_RS22440 ENOG4105D4Y metalloprotease FOC93_RS22455 ENOG4105BZU Histidine kinase FOC93_RS22470 ENOG4105DF6 Fe-S oxidoreductase FOC93_RS22480 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC93_RS22485 ENOG4105C1G acyl-Coa dehydrogenase FOC93_RS22490 ENOG4105C1G acyl-Coa dehydrogenase FOC93_RS22505 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOC93_RS22525 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC93_RS22530 ENOG4105CBT Fructose-1,6-bisphosphatase FOC93_RS22535 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC93_RS22545 ENOG4107104 thymidine kinase FOC93_RS22550 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC93_RS22555 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC93_RS22560 ENOG4108ZXQ stage ii sporulation protein r FOC93_RS22570 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC93_RS22585 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC93_RS22590 ENOG4108VGI doxx family FOC93_RS22605 ENOG4108YZG isomerase FOC93_RS22610 ENOG4108UIC UPF0340 protein FOC93_RS22615 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOC93_RS22635 ENOG41062M3 atp synthase FOC93_RS22640 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC93_RS22690 ENOG4105BZU Histidine kinase FOC93_RS22695 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC93_RS22705 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC93_RS22710 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC93_RS22735 ENOG4105D65 subunit l FOC93_RS22740 ENOG4105C8S subunit m FOC93_RS22745 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC93_RS22750 ENOG4106778 Protein of unknown function (DUF1146) FOC93_RS22770 ENOG4105DY9 regulatoR FOC93_RS22785 ENOG4105FRN stage II sporulation protein FOC93_RS22795 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC93_RS22810 ENOG4107YJ4 chain length determinant protein FOC93_RS22815 ENOG4105HTX biosynthesis protein FOC93_RS22820 ENOG4107YJ4 chain length determinant protein FOC93_RS22825 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC93_RS22830 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC93_RS22835 ENOG4105D3Q Sugar transferase FOC93_RS22845 ENOG4108PTS heparinase ii FOC93_RS22855 ENOG4107U9V N5-(Carboxyethyl)ornithine synthase FOC93_RS22890 ENOG4107EF8 Glycosyl transferase (Group 1 FOC93_RS22895 ENOG4105CPK Glycosyl transferase (Group 1 FOC93_RS22905 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC93_RS22910 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC93_RS22920 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC93_RS22925 ENOG4108KGH TRANSCRIPTIONal FOC93_RS22935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS22940 ENOG4105BZU Histidine kinase FOC93_RS22955 ENOG4105CXY transporter FOC93_RS22975 ENOG4105C19 ABC transporter FOC93_RS22980 ENOG4107RBB ABC transporter, permease FOC93_RS22990 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_RS23020 ENOG4105C0D helicase FOC93_RS23025 ENOG4105KBK Zinc finger, swim domain protein FOC93_RS23050 ENOG41069ER domain protein FOC93_RS23055 ENOG4105C94 Transporter FOC93_RS23060 ENOG4107R8N Glycosyl transferase, family 2 FOC93_RS23085 ENOG4105E0M Sulfatase FOC93_RS23095 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC93_RS23105 ENOG4105DAA L-lactate FOC93_RS23140 ENOG4107RSM transcriptional regulator FOC93_RS23145 ENOG4105ECB domain protein FOC93_RS23165 ENOG4105VZJ PTS System FOC93_RS23175 ENOG4105VCP PTS System FOC93_RS23185 ENOG4105CK1 PTS System FOC93_RS23190 ENOG4105VCP PTS System FOC93_RS23195 ENOG4105F8D glycoside hydrolase family 4 FOC93_RS23215 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC93_RS23225 ENOG4105ESV Glycosyl transferase, family 4 FOC93_RS23235 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC93_RS23240 ENOG4108KGH TRANSCRIPTIONal FOC93_RS23245 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC93_RS23255 ENOG4105KVH Transcriptional regulator FOC93_RS23270 ENOG41081UC Inherit from COG: Competence protein FOC93_RS23275 ENOG4105VEQ Cold shock protein FOC93_RS23280 ENOG4105MS2 ribosomal subunit Interface protein FOC93_RS23310 ENOG4108RDQ ABC transporter FOC93_RS23335 ENOG4105CAK Cell division ATP-binding protein ftsE FOC93_RS23340 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC93_RS23345 ENOG4105CN1 protease FOC93_RS23355 ENOG4105BZ1 (ABC) transporter FOC93_RS23370 ENOG4108WS4 fmn reductase FOC93_RS23380 ENOG4105DUM transcriptional regulator, lysR family FOC93_RS23400 ENOG4107TXC Transcriptional regulator FOC93_RS23415 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC93_RS23420 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC93_RS23430 ENOG41086DT Membrane protein of unknown function FOC93_RS23450 ENOG4108S4C acetyltransferase FOC93_RS23460 ENOG4105C3M thioredoxin reductase FOC93_RS23470 ENOG4108Z4K mutator MutT protein FOC93_RS23480 ENOG4105CHW UPF0052 protein FOC93_RS23490 ENOG4105KRI phosphocarrier protein (HPr FOC93_RS23500 ENOG4108QY0 Membrane FOC93_RS23515 ENOG4105CZ3 stage V sporulation protein ad FOC93_RS23520 ENOG41090VF Stage v sporulation protein ac FOC93_RS23540 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_RS23590 ENOG41067MG lrgb family FOC93_RS23595 ENOG4105XZU Preprotein translocase, subunit SecG FOC93_RS23605 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC93_RS23655 ENOG4105C19 ABC transporter FOC93_RS23660 ENOG4107RBB ABC transporter, permease FOC93_RS23700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS23715 ENOG4105CM4 permease protein FOC93_RS23720 ENOG4108IPW abc transporter atp-binding protein FOC93_RS23735 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FOC93_RS23740 ENOG4108V2W Carbonate dehydratase FOC93_RS23765 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC93_RS23770 ENOG4105C5H ABC transporter FOC93_RS23790 ENOG4105WMR Protein CrcB homolog FOC93_RS23795 ENOG4105WMR Protein CrcB homolog FOC93_RS23805 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_RS23815 ENOG4105D4A Cell wall formation (By similarity) FOC93_RS23820 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC93_RS23835 ENOG4105KVH Transcriptional regulator FOC93_RS23840 ENOG4105F27 Major Facilitator FOC93_RS23845 ENOG4105CV8 reductase FOC93_RS23860 ENOG4108RYK Nad-dependent epimerase dehydratase FOC93_RS23875 ENOG4105D9N nucleoside FOC93_RS23880 ENOG4105D9N nucleoside FOC93_RS23885 ENOG4105DHF Membrane FOC93_RS23890 ENOG41090A1 ferritin FOC93_RS23900 ENOG4108URH decarboxylase FOC93_RS23915 ENOG4108RMU ferritin dps family protein FOC93_RS23925 ENOG4105NCW Trka-c domain protein FOC93_RS23930 ENOG4107S91 Sodium hydrogen exchanger FOC93_RS23935 ENOG4107T5V SNARE associated Golgi FOC93_RS23960 ENOG4105D4Y metalloprotease FOC93_RS23965 ENOG4105VG1 fes assembly suf system protein FOC93_RS23970 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_RS23985 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC93_RS24000 ENOG4105BZU Histidine kinase FOC93_RS24005 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS24010 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC93_RS24020 ENOG4107ZTW SNARE associated Golgi FOC93_RS24055 ENOG4107AYK membrAne FOC93_RS24065 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC93_RS24080 ENOG4107R7I amino acid FOC93_RS24085 ENOG4108SUT Major Facilitator Superfamily FOC93_RS24100 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC93_RS24120 ENOG4105DZ1 carboxypeptidase FOC93_RS24135 ENOG4105CHU acetyl-coa acetyltransferase FOC93_RS24140 ENOG4105C1G acyl-Coa dehydrogenase FOC93_RS24145 ENOG4108W8B Beta-lactamase domain protein FOC93_RS24170 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC93_RS24190 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC93_RS24215 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC93_RS24220 ENOG4108UMI ABC transporter, permease FOC93_RS24225 ENOG4105D01 (LipO)protein FOC93_RS24230 ENOG4105D01 (LipO)protein FOC93_RS24235 ENOG4105C3K feS assembly ATPase SufC FOC93_RS24240 ENOG4105JRK feS assembly protein SufD FOC93_RS24245 ENOG4105C9B Cysteine desulfurase FOC93_RS24250 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC93_RS24255 ENOG4105DIW FeS assembly protein SUFB FOC93_RS24260 ENOG4107R8B 5'-nucleotidase FOC93_RS24265 ENOG4105KZD Domain of unknown function (DUF1805) FOC93_RS24270 ENOG4108YTE sporulation protein YunB FOC93_RS24275 ENOG4105FAA peptidase M23 FOC93_RS24300 ENOG41090T1 Membrane FOC93_RS24305 ENOG4107TXC Transcriptional regulator FOC93_RS24310 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC93_RS24315 ENOG4105MMD transcriptional regulator FOC93_RS24330 ENOG4105CBT Fructose-1,6-bisphosphatase FOC93_RS24345 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC93_RS24350 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC93_RS24360 ENOG4105DAX Pfam:DUF2983 FOC93_RS24380 ENOG4108W5N phosphatidylglycerophosphatase a FOC93_RS24395 ENOG41083MR nifu domain-containing protein FOC93_RS24430 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC93_RS24435 ENOG4105C4B ABC transporter, permease FOC93_RS24440 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC93_RS24465 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC93_RS24480 ENOG4105EWC Purine nucleoside phosphorylase FOC93_RS24510 ENOG4105CEP NADH dehydrogenase FOC93_RS24525 ENOG41069ER domain protein FOC93_RS24545 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC93_RS24560 ENOG4105KA0 thioesterase Superfamily protein FOC93_RS24580 ENOG4107R3E Citrate transporter FOC93_RS24590 ENOG4105Y38 Kinase-associated protein B FOC93_RS24605 ENOG4105C87 Aminotransferase class I and II FOC93_RS24615 ENOG4108MUZ hydrolase FOC93_RS24620 ENOG4105C5I Dehydrogenase FOC93_RS24625 ENOG4108ZB6 transcriptional regulator AsnC family FOC93_RS24630 ENOG4105CHM Aminotransferase FOC93_RS24640 ENOG4105WG9 Conserved Protein FOC93_RS24655 ENOG4107PBV potassium channel FOC93_RS24660 ENOG4105KT7 mgtC SapB transporter FOC93_RS24695 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC93_RS24810 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC93_RS24845 ENOG4105VEQ Cold shock protein FOC93_RS24855 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC93_RS24860 ENOG4105E4F Isochorismate synthase FOC93_RS24870 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC93_RS24875 ENOG4108IPT Naphthoate synthase FOC93_RS24885 ENOG4105DTQ mandelate racemase muconate lactonizing FOC93_RS24905 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC93_RS24930 ENOG4105C6Z Gluconate FOC93_RS24980 ENOG41082BM Transcriptional regulator, arsr family FOC93_RS25000 ENOG41086D8 Transcriptional regulator FOC93_RS25005 ENOG4105C19 ABC transporter FOC93_RS25020 ENOG4107ZTW SNARE associated Golgi FOC93_RS25050 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC93_RS25055 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC93_RS25080 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_RS25085 ENOG4105BZU Histidine kinase FOC93_RS25115 ENOG41087YS Phage shock protein A FOC93_RS25150 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC93_RS25155 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC93_RS25160 ENOG4108V2W Carbonate dehydratase FOC93_RS25225 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC93_RS25235 ENOG4105D2X ABC transporter substrate-binding protein FOC93_RS25260 ENOG4107T7U Sulfatase FOC93_RS25265 ENOG4107S9D Alpha beta hydrolase FOC93_RS25270 ENOG4105BZU Histidine kinase FOC93_RS25275 ENOG4105BZU Histidine kinase FOC93_RS25315 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC93_RS25325 ENOG4105EPU Molybdenum cofactor synthesis domain protein FOC93_RS25335 ENOG4105BZF Glycosyl transferase (Group 1 FOC93_RS25340 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC93_RS25345 ENOG4108Z0R Transferase FOC93_RS25350 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC93_RS25375 ENOG4105DA5 (ABC) transporter FOC93_RS25385 ENOG4105N5T Radical SAM Protein FOC93_RS25405 ENOG4105C19 ABC transporter FOC93_RS25420 ENOG4105NCW Trka-c domain protein FOC93_RS25425 ENOG4107S91 Sodium hydrogen exchanger FOC93_RS25430 ENOG410605W Major Facilitator FOC93_RS25435 ENOG4105C8T Leucyl-tRNA synthetase FOC93_RS25465 ENOG4108B31 Spore germination protein FOC93_RS25475 ENOG4105DWV Homoserine O-trans-acetylase FOC93_RS25485 ENOG41085GJ domain protein FOC93_RS25505 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC93_RS25510 ENOG4105D06 uba thif-type nad fad binding protein FOC93_RS25520 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC93_RS25525 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC93_RS25530 ENOG4108ZAF Molybdopterin FOC93_RS25545 ENOG4105CSC Glucose uptake protein FOC93_RS25550 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC93_RS25555 ENOG4108VJ1 Transcriptional regulator (CarD family FOC93_RS25590 ENOG4105CBX hi0933 family FOC93_RS25605 ENOG4105YW5 deoR family transcriptional regulator FOC93_RS25610 ENOG4107QSE Dipeptidase FOC93_RS25620 ENOG4108IUM Glycogen debranching enzyme FOC93_RS25625 ENOG4108V15 phosphotransferase enzyme family FOC93_RS25640 ENOG4105C8F Beta-lactamase domain protein FOC93_RS25670 ENOG4108VDD TRNA binding domain protein FOC93_RS25680 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC93_RS25715 ENOG4105C88 aminopeptidase FOC93_RS25735 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC93_RS25740 ENOG4105ETE Transcriptional regulator (LacI family FOC93_RS25760 ENOG4105EP9 oxidoreductase FOC93_RS25765 ENOG4107SNB ankyrin repeat protein YahD FOC93_RS25770 ENOG4105BZU Histidine kinase FOC93_RS25775 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_RS25790 ENOG4105DGU Histone deacetylase FOC93_RS25795 ENOG4105W87 Cbs domain FOC93_RS25800 ENOG4105F1V Acetoin utilization protein FOC93_RS25810 ENOG4108UW5 maltose o-acetyltransferase FOC93_RS25820 ENOG4105EMN RNA polymerase sigma factor FOC93_RS25975 ENOG4105C28 cystathionine FOC93_RS25985 ENOG4105U5Y Transcriptional regulator FOC93_RS25995 ENOG4105RQF LysR family Transcriptional regulator FOC93_RS26020 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC93_RS26030 ENOG4105EFZ amidohydrolase FOC93_RS26045 ENOG4105KBJ sporulation protein ytfj FOC93_RS26050 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC93_RS26060 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC93_RS26080 ENOG4108JYZ YitT family FOC93_RS26115 ENOG4107YZX Universal stress protein FOC93_RS26135 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC93_RS26175 ENOG4105DC7 peptidase M24 FOC93_RS26180 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC93_RS26205 ENOG4105SFS phosphoesterase RecJ domain protein FOC93_RS26215 ENOG4105VV2 FOC93_RS26220 ENOG4105C0B DNA polymerase III (alpha subunit) FOC93_RS26225 ENOG4105C6K Malic enzyme FOC93_RS26230 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC93_RS26255 ENOG4105FS0 cytoplasmic membrane protein FOC93_RS26260 ENOG4108REF Sporulation integral membrane protein ytvi FOC93_RS26270 ENOG4105BZN citrate synthase FOC93_RS26275 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC93_RS26295 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_RS26300 ENOG4105BZU Histidine kinase FOC93_RS26305 ENOG4105C2M dna polymerase I FOC93_RS26310 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC93_RS26320 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC93_RS26325 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC93_RS26355 ENOG4108TDW sporulation protein YtxC FOC93_RS26360 ENOG4105C22 threonyL-tRNA synthetase FOC93_RS26365 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC93_RS26385 ENOG4105CN9 Peptidase m42 family protein FOC93_RS26390 ENOG4108JGH Tetr family transcriptional regulator FOC93_RS26395 ENOG4105CW7 secretion protein, HlyD family FOC93_RS26400 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_RS26430 ENOG4108RWN rrna methyltransferase FOC93_RS26440 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC93_RS26445 ENOG4105C5S asparaginyl-tRNA synthetase FOC93_RS26465 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOC93_RS26480 ENOG4105DCG PHP domain protein FOC93_RS26490 ENOG4105FE9 pseudouridine synthase FOC93_RS26500 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC93_RS26510 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC93_RS26525 ENOG4105E0A ABC, transporter FOC93_RS26530 ENOG4105KFN sortase, SrtB family FOC93_RS26540 ENOG4105DR4 Methyltransferase FOC93_RS26555 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_RS26620 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_RS26625 ENOG4107Z3H Transcriptional regulator, TetR family FOC93_RS26630 ENOG41060WC Enoyl-CoA hydratase FOC93_RS26635 ENOG4105BZJ Electron transfer flavoprotein FOC93_RS26640 ENOG4105C10 Electron transfer flavoprotein FOC93_RS26645 ENOG4105K63 Thioredoxin FOC93_RS26650 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC93_RS26660 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC93_RS26670 ENOG4105E33 succinate dehydrogenase FOC93_RS26680 ENOG4108VXD carboxy-peptidase FOC93_RS26685 ENOG4105E14 MotA TolQ exbB proton channel FOC93_RS26690 ENOG4105ER2 Ompa motb domain protein FOC93_RS26695 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC93_RS26700 ENOG4108IUX (ABC) transporter FOC93_RS26705 ENOG4105RHA ABC transporter, permease FOC93_RS26710 ENOG4108Z40 Transcriptional regulator FOC93_RS26715 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC93_RS26725 ENOG4108JCI Transcriptional regulator FOC93_RS26730 ENOG41067S9 phage shock protein C, PspC FOC93_RS26735 ENOG4105DZC cytosine deaminase FOC93_RS26745 ENOG4105PFC Transcriptional regulator FOC93_RS26760 ENOG4108XJQ germination protein FOC93_RS26775 ENOG4105M59 Phosphodiesterase, mj0936 family FOC93_RS26795 ENOG4108QCI YvbH-like oligomerisation region FOC93_RS26820 ENOG4108IUQ atp-dependent protease FOC93_RS26840 ENOG4105K56 Transcriptional regulator FOC93_RS26865 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC93_RS26875 ENOG41068KH stage VI sporulation protein D FOC93_RS26885 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC93_RS26890 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC93_RS26910 ENOG4105DFF Rod shape-determining protein mreb FOC93_RS26930 ENOG4107QMS site-determining protein FOC93_RS26945 ENOG4105C03 ribonuclease FOC93_RS26955 ENOG4105X36 (ribosomal) protein FOC93_RS26970 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC93_RS26980 ENOG4105EWM Histidine kinase FOC93_RS26985 ENOG4105C19 ABC transporter FOC93_RS27000 ENOG4105CQC Prephenate dehydratase FOC93_RS27005 ENOG4108RPX mosc domain containing protein FOC93_RS27020 ENOG4108IYU L-aspartate oxidase FOC93_RS27025 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC93_RS27030 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FOC93_RS27060 ENOG4108HUF Transporter FOC93_RS27075 ENOG41061AI Protein of unknown function (DUF2905) FOC93_RS27090 ENOG4105VIE preprotein translocase, subunit YajC FOC93_RS27100 ENOG4108QG2 Membrane FOC93_RS27105 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC93_RS27115 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC93_RS27120 ENOG41076HS cation diffusion facilitator family transporter FOC93_RS27125 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC93_RS27135 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC93_RS27140 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FOC93_RS27150 ENOG4105CUT histidyl-tRNA synthetase FOC93_RS27160 ENOG4105CUZ uba thif-type nad fad binding protein FOC93_RS27165 ENOG4108VCI transcription factor, rsfa family FOC93_RS27170 ENOG4105D1H recombination factor protein RarA FOC93_RS27180 ENOG4105C3J Cysteine desulfurase FOC93_RS27185 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC93_RS27195 ENOG4105C7H Helicase, RecD TraA family FOC93_RS27200 ENOG41060CR FOC93_RS27215 ENOG4105C02 permease FOC93_RS27225 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC93_RS27245 ENOG4105HHA aminodeoxychorismate lyase FOC93_RS27255 ENOG4105XYU peptidase (U32 family) FOC93_RS27260 ENOG4105CFP Peptidase U32 FOC93_RS27270 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOC93_RS27280 ENOG4107XRG penicillin-binding protein FOC93_RS27310 ENOG4105C28 cystathionine FOC93_RS27315 ENOG4105C0A alcohol dehydrogenase FOC93_RS27325 ENOG4108V5C ABC transporter FOC93_RS27330 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC93_RS27370 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC93_RS27380 ENOG4105MIR Phenylalanine 4-monooxygenase FOC93_RS27385 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC93_RS27415 ENOG4108MUZ hydrolase FOC93_RS27420 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FOC93_RS27425 ENOG4105G6Z alkaline phosphatase FOC93_RS27440 ENOG4108TVJ Nitroreductase FOC93_RS27460 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_RS27475 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC93_RS27480 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC93_RS27490 ENOG410812S Rna-binding protein FOC93_RS27500 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC93_RS27510 ENOG4105DXX methyltransferase FOC93_RS27520 ENOG4105KQC Competence protein FOC93_RS27525 ENOG4108UK2 deaminase FOC93_RS27530 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC93_RS27540 ENOG4105TQK DNA polymerase iii, delta' subunit FOC93_RS27565 ENOG4105KVH Transcriptional regulator FOC93_RS27570 ENOG4105CSA Coproporphyrinogen iii oxidase FOC93_RS27600 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC93_RS27605 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC93_RS27615 ENOG4105KTH gatB Yqey FOC93_RS27620 ENOG41068P3 sporulation protein YqfC FOC93_RS27630 ENOG4105C9A Phoh family FOC93_RS27635 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC93_RS27645 ENOG4107YR5 Diacylglycerol kinase FOC93_RS27650 ENOG4105KG3 cytidine deaminase FOC93_RS27655 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC93_RS27685 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC93_RS27690 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_RS27705 ENOG4105EGD dinuclear metal center protein, YbgI family FOC93_RS27730 ENOG41069ZM Protein of unknown function (DUF2624) FOC93_RS27735 ENOG4108JYZ YitT family FOC93_RS27740 ENOG4105FDK ABC transporter FOC93_RS27750 ENOG4105N80 Ferric uptake regulator, Fur family FOC93_RS27775 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC93_RS27785 ENOG4107RF6 penicillin-binding protein FOC93_RS27795 ENOG4105C8U phosphate abc transporter FOC93_RS27800 ENOG4105C8U phosphate abc transporter FOC93_RS27805 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC93_RS27810 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC93_RS27825 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC93_RS27835 ENOG4105DKQ ROK family FOC93_RS27845 ENOG4105C5X domain protein FOC93_RS27865 ENOG4105C28 cystathionine FOC93_RS27870 ENOG4105C28 cystathionine FOC93_RS27880 ENOG4105C3R Methionine synthase FOC93_RS27885 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC93_RS28005 ENOG4105C0D helicase FOC93_RS28035 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC93_RS28040 ENOG4105CJ1 ABC, transporter FOC93_RS28070 ENOG41080TC multidrug resistance protein FOC93_RS28095 ENOG4105WZW rhodanese family FOC93_RS28100 ENOG41082GG biotin lipoate A B protein ligase FOC93_RS28130 ENOG4107YBY Hydrolase FOC93_RS28140 ENOG4105CBJ Metal-dependent enzyme FOC93_RS28150 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FOC93_RS28155 ENOG4105DC7 peptidase M24 FOC93_RS28180 ENOG4105CD2 stage iii sporulation protein aa FOC93_RS28185 ENOG4105KR5 Stage iii sporulation protein FOC93_RS28190 ENOG4108CQH stage III sporulation protein AC FOC93_RS28195 ENOG4105KQ4 Stage iii sporulation protein ad FOC93_RS28205 ENOG410644B Stage III sporulation protein af FOC93_RS28230 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC93_RS28235 ENOG4108ZSR alkaline shock protein FOC93_RS28245 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOC93_RS28260 ENOG4105CTB Polyprenyl synthetase FOC93_RS28270 ENOG4105DX0 Hemolysin A FOC93_RS28275 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FOC93_RS28280 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC93_RS28285 ENOG4105S1Z Stage IV sporulation protein B FOC93_RS28290 ENOG4107QQR Sporulation FOC93_RS28305 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC93_RS28315 ENOG4108JUB Transcriptional regulator FOC93_RS28325 ENOG4107RDP Dehydrogenase FOC93_RS28345 ENOG4105CPP Dehydrogenase, E1 component FOC93_RS28350 ENOG4105C7S Dehydrogenase FOC93_RS28360 ENOG4108QY0 Membrane FOC93_RS28370 ENOG4105G7B Protein of unknown function (DUF2992) FOC93_RS28380 ENOG4108HW3 (ABC) transporter FOC93_RS28385 ENOG4105E5Q amino acid AbC transporter FOC93_RS28390 ENOG4105CDA abc transporter atp-binding protein FOC93_RS28395 ENOG4108QEG Membrane FOC93_RS28400 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC93_RS28415 ENOG4105D9U N-acetyltransferase FOC93_RS28420 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC93_RS28435 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOC93_RS28450 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC93_RS28465 ENOG4105EJQ L-serine dehydratase FOC93_RS28470 ENOG4105II7 pyrroline-5-carboxylate reductase FOC93_RS28475 ENOG41069FQ Metallo-beta-lactamase superfamily FOC93_RS28480 ENOG4108IXY short-chain dehydrogenase reductase FOC93_RS28495 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC93_RS28510 ENOG4105DBV ornithine carbamoyltransferase FOC93_RS28535 ENOG4105CGH 5'-nucleotidase FOC93_RS28540 ENOG4105DFD Na H antiporter FOC93_RS28550 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC93_RS28565 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC93_RS28570 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC93_RS28595 ENOG4108R6K riboflavin synthase, subunit alpha FOC93_RS28600 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC93_RS28620 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC93_RS28625 ENOG4105ETE Transcriptional regulator (LacI family FOC93_RS28635 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC93_RS28655 ENOG4105RHY Pfam:UPF0157 FOC93_RS28665 ENOG4105CPC Aldo Keto reductase FOC93_RS28685 ENOG4105MZ9 stage II sporulation protein m FOC93_RS28690 ENOG4105I3K Ferric uptake regulator, Fur family FOC93_RS28700 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC93_RS28725 ENOG4105D7N magnesium and cobalt transport protein CorA FOC93_RS28755 ENOG4105DVE abc transporter atp-binding protein FOC93_RS28760 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC93_RS28765 ENOG4105DZ1 carboxypeptidase FOC93_RS28770 ENOG41082AN stage II sporulation protein FOC93_RS28780 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_RS28785 ENOG4105C8J )-transporter FOC93_RS28805 ENOG41090VF Stage v sporulation protein ac FOC93_RS28810 ENOG4105CZ3 stage V sporulation protein ad FOC93_RS28820 ENOG4105G6R Stage v sporulation protein ae FOC93_RS28830 ENOG4105J7I hydrolase FOC93_RS28835 ENOG4105PTM secreted protein FOC93_RS28840 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC93_RS28875 ENOG4105CE4 GlcNAc 6-P deacetylase FOC93_RS28895 ENOG4105CID antiterminator FOC93_RS28910 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC93_RS28930 ENOG4105BZU Histidine kinase FOC93_RS28940 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC93_RS28955 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC93_RS28980 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC93_RS29000 ENOG4105DTD Dehydrogenase FOC93_RS29005 ENOG4105K7K Transcriptional regulator FOC93_RS29035 ENOG4105CHU acetyl-coa acetyltransferase FOC93_RS29080 ENOG4105CG3 alpha amylase, catalytic region FOC93_RS29090 ENOG4107FKK extracellular solute-binding protein family 1 FOC93_RS29100 ENOG4105EG2 ABC transporter, permease FOC93_RS29105 ENOG4105FKQ transcriptional regulator FOC93_RS29110 ENOG4105CHM Aminotransferase FOC93_RS29120 ENOG4108HGU Histidine kinase FOC93_RS29140 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FOC93_RS29175 ENOG4105UIN FOC93_RS29185 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC93_RS29200 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC93_RS29205 ENOG4105EPM Diguanylate phosphodiesterase FOC93_RS29220 ENOG4107IN1 Protein of unknown function (DUF1797) FOC93_RS29230 ENOG4108XRC Protein of unknown function (DUF458) FOC93_RS29265 ENOG4107ZYR domain protein FOC93_RS29270 ENOG4105CN5 Metallo-Beta-Lactamase FOC93_RS29280 ENOG4108X4Q Hydrolase FOC93_RS29285 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC93_RS29300 ENOG4105CPP Dehydrogenase, E1 component FOC93_RS29350 ENOG4105CXN decarboxylase FOC93_RS29370 ENOG4105ECY inositol monophosphatase FOC93_RS29380 ENOG4105CI3 gtp-binding protein typa FOC93_RS29385 ENOG4105QA2 FOC93_RS29405 ENOG4108IAB Phoh family FOC93_RS29420 ENOG4105CNI cell division protein FtsW FOC93_RS29425 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC93_RS29475 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC93_RS29490 ENOG4107TB6 phosphoglycerate mutase FOC93_RS29510 ENOG4106H78 methyltransferase FOC93_RS29520 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC93_RS29525 ENOG4105D78 K07001 NTE family protein FOC93_RS29530 ENOG41063PX domain protein FOC93_RS29540 ENOG4105KNH Nucleic acid-binding protein FOC93_RS29565 ENOG41074B2 UPF0747 protein FOC93_RS29580 ENOG4105CJN penicillin-binding protein FOC93_RS29585 ENOG4105CJN penicillin-binding protein FOC93_RS29590 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC93_RS29605 ENOG4105CNI cell division protein FtsW FOC93_RS29610 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC93_RS29615 ENOG4105D4A Cell wall formation (By similarity) FOC93_RS29625 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC93_RS29630 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC93_RS29640 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_RS29650 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC93_RS29655 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC93_RS29660 ENOG4105DFA alanine racemase domain protein FOC93_RS29670 ENOG41067XK integral membrane protein FOC93_RS29675 ENOG4105DBK s4 domain protein FOC93_RS29700 ENOG4105C34 Pseudouridine synthase FOC93_RS29720 ENOG4105CD3 dihydroorotase FOC93_RS29730 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FOC93_RS29735 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FOC93_RS29770 ENOG4105DC7 peptidase M24 FOC93_RS29790 ENOG4105DSJ YicC domain protein FOC93_RS29810 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC93_RS29815 ENOG4105C25 Primosomal protein n' FOC93_RS29830 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC93_RS29840 ENOG4108ZF3 Phosphatase FOC93_RS29845 ENOG4105D9P serine threonine protein kinase FOC93_RS29850 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC93_RS29855 ENOG4105DJV ribulose-phosphate 3-epimerase FOC93_RS29860 ENOG4105FJ0 thiamine FOC93_RS29875 ENOG4108ZAA Alkaline-shock protein FOC93_RS29880 ENOG4105DP4 dak2 domain fusion protein ylov FOC93_RS29885 ENOG4105CB5 ATP-dependent DNA helicase recG FOC93_RS29900 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC93_RS29905 ENOG4105CHR reductase FOC93_RS29920 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC93_RS29925 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC93_RS29945 ENOG4105VB6 UPF0109 protein FOC93_RS29970 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC93_RS29985 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC93_RS29990 ENOG4105C79 DNA protecting protein DprA FOC93_RS29995 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC93_RS30005 ENOG4108HE4 integrase family FOC93_RS30035 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC93_RS30045 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC93_RS30050 ENOG4105KNE Phosphatidate cytidylyltransferase FOC93_RS30055 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC93_RS30060 ENOG4105DZP Membrane-associated zinc metalloprotease FOC93_RS30070 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC93_RS30080 ENOG4105CHV Transcription elongation factor NusA FOC93_RS30085 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC93_RS30090 ENOG4105VHM ribosomal protein FOC93_RS30100 ENOG4105W7A Protein of unknown function (DUF503) FOC93_RS30115 ENOG4105DTN riboflavin biosynthesis protein ribF FOC93_RS30135 ENOG4105C1V Peptidase, M16 FOC93_RS30145 ENOG4105E35 Dipicolinate synthase subunit A FOC93_RS30150 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC93_RS30155 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC93_RS30165 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC93_RS30175 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC93_RS30185 ENOG4105CNU cell division protein FtsK FOC93_RS30190 ENOG4105FDP GntR family transcriptional regulator FOC93_RS30195 ENOG4105DIH basic membrane FOC93_RS30200 ENOG4108JQ9 ABC transporter FOC93_RS30205 ENOG4105UIB (ABC) transporter FOC93_RS30225 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC93_RS30230 ENOG4105XZV Protein of unknown function (DUF3243) FOC93_RS30245 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC93_RS30275 ENOG4105D48 metallophosphoesterase FOC93_RS30280 ENOG4105MCT stage V sporulation protein S FOC93_RS30285 ENOG4108IGT Dipeptidase FOC93_RS30290 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC93_RS30295 ENOG4105DQU oxidoreductase, subunit beta FOC93_RS30330 ENOG410890F Dynamin family FOC93_RS30335 ENOG4105E0M Sulfatase FOC93_RS30345 ENOG4105F0V Cell wall hydrolase FOC93_RS30355 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FOC93_RS30360 ENOG4105CS2 ec 3.2.1.21 FOC93_RS30365 ENOG4108S3Y transcriptional regulator FOC93_RS30385 ENOG41067MG lrgb family FOC93_RS30405 ENOG4105C5E polysaccharide biosynthesis protein FOC93_RS30425 ENOG4105BZU Histidine kinase FOC93_RS30450 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC93_RS30455 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC93_RS30485 ENOG4105E0A ABC, transporter FOC93_RS30490 ENOG4105NIV Esterase FOC93_RS30500 ENOG4105VPX protein, conserved in bacteria FOC93_RS30505 ENOG410681U heavy metal transport detoxification protein FOC93_RS30510 ENOG4105C59 p-type ATPase FOC93_RS30520 ENOG4105K70 DNA-binding protein FOC93_RS30525 ENOG4105TMB Formate nitrite transporter FOC93_RS30540 ENOG4105C85 amino acid FOC93_RS30550 ENOG4108SJC Membrane FOC93_RS30555 ENOG4107QW4 alcohol dehydrogenase FOC93_RS30560 ENOG4105E98 transcriptional regulator DeoR family FOC93_RS30565 ENOG4105DE4 1-phosphofructokinase FOC93_RS30570 ENOG4105DM4 PTS System FOC93_RS30575 ENOG41069ER domain protein FOC93_RS30605 ENOG4106F1P AAA ATPase, central domain protein FOC93_RS30615 ENOG4105EN6 Membrane FOC93_RS30620 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC93_RS30625 ENOG4105CXI aluminum resistance protein FOC93_RS30630 ENOG4105KV4 Transcriptional regulator FOC93_RS30635 ENOG4105C5F glutamine synthetase FOC93_RS30640 ENOG4105K7K Transcriptional regulator FOC93_RS30660 ENOG4108SVB resolvase FOC93_RS30670 ENOG4105CGH 5'-nucleotidase FOC93_RS30675 ENOG4108HW3 (ABC) transporter FOC93_RS30710 ENOG4105BZ1 (ABC) transporter FOC93_RS30715 ENOG4105BZ1 (ABC) transporter FOC93_RS30755 ENOG41067MG lrgb family FOC93_RS30765 ENOG4107RSM transcriptional regulator FOC93_RS30780 ENOG4105CJ1 ABC, transporter FOC93_RS30800 ENOG4107QIV Cytochrome c biogenesis protein FOC93_RS30825 ENOG4108Z0Z intracellular protease Pfpi family FOC93_RS30830 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC93_RS30845 ENOG4105CGP Urocanate hydratase