locus-tag class description FOC96_RS00035 ENOG4105K4H Nlp p60 protein FOC96_RS00125 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC96_RS00200 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC96_RS00250 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC96_RS00300 ENOG4107QJE Chromosome Partitioning Protein FOC96_RS00500 ENOG4105DHF Membrane FOC96_RS00535 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC96_RS00595 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC96_RS00625 ENOG4108IBT Inherit from COG: transposase FOC96_RS00640 ENOG41089BK Glutamine amido-transferase FOC96_RS00645 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC96_RS00675 ENOG4108IMY Transcriptional regulator FOC96_RS00690 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC96_RS00695 ENOG4105NA0 Transcriptional regulator FOC96_RS00710 ENOG4108IMY Transcriptional regulator FOC96_RS00725 ENOG4105CZV ABC transporter FOC96_RS00740 ENOG4105D9P serine threonine protein kinase FOC96_RS00745 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FOC96_RS00915 ENOG4105D7V transposase FOC96_RS00925 ENOG4105BZU Histidine kinase FOC96_RS00930 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC96_RS00990 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC96_RS01225 ENOG4105VIZ double-strand break repair protein FOC96_RS01285 ENOG4105CNU cell division protein FtsK FOC96_RS01430 ENOG4105CID antiterminator FOC96_RS01435 ENOG4105C5Y PTS System FOC96_RS01440 ENOG4105CS2 ec 3.2.1.21 FOC96_RS01525 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC96_RS01535 ENOG4105EKQ RNA-directed DNA polymerase FOC96_RS01545 ENOG4105FA2 dna polymerase iii FOC96_RS01565 ENOG4105DUX Transporter FOC96_RS01640 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FOC96_RS01710 ENOG4107Y9E nuclease FOC96_RS01715 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC96_RS01730 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC96_RS01775 ENOG41060AI SEC-C motif FOC96_RS01865 ENOG4106F1P AAA ATPase, central domain protein FOC96_RS01910 ENOG4105EKQ RNA-directed DNA polymerase FOC96_RS01960 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC96_RS02025 ENOG4107QHF type ii secretion system protein e FOC96_RS02090 ENOG4105CDU Replicative dna helicase FOC96_RS02205 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FOC96_RS02315 ENOG4105CNU cell division protein FtsK FOC96_RS02425 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC96_RS02475 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC96_RS02500 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC96_RS02505 ENOG4108FPN Integrase FOC96_RS02530 ENOG4105BZU Histidine kinase FOC96_RS02535 ENOG4108VB1 regulatoR FOC96_RS02570 ENOG4105C6E dna polymerase iii FOC96_RS02615 ENOG4108KU9 integrase family FOC96_RS02620 ENOG4108FPN Integrase FOC96_RS02685 ENOG41086D8 Transcriptional regulator FOC96_RS02690 ENOG4105G7B Protein of unknown function (DUF2992) FOC96_RS02705 ENOG4108FPN Integrase FOC96_RS02890 ENOG4105KRN Transcriptional regulator, abrb family FOC96_RS02900 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC96_RS02965 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC96_RS02970 ENOG4105E09 nadh pyrophosphatase FOC96_RS03035 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC96_RS03105 ENOG4105XSJ toxin secretion phage lysis holin FOC96_RS03185 ENOG4105XB7 anti-repressor protein FOC96_RS03225 ENOG4105CDU Replicative dna helicase FOC96_RS03305 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC96_RS03395 ENOG4105C7N Xanthine uracil vitamin C permease FOC96_RS03410 ENOG4107EV6 Inherit from COG: YD repeat protein FOC96_RS03425 ENOG4108TYN CAAX amino terminal protease family protein FOC96_RS03440 ENOG4105C5H ABC transporter FOC96_RS03450 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC96_RS03455 ENOG41072GX Peptidase M22 Glycoprotease FOC96_RS03460 ENOG4105K8N protein family UPF0079, ATPase FOC96_RS03560 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC96_RS03570 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC96_RS03575 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC96_RS03585 ENOG4107ZXI Rhomboid family FOC96_RS03600 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC96_RS03605 ENOG4105CPF Cell wall formation (By similarity) FOC96_RS03615 ENOG4105CUB amino acid FOC96_RS03625 ENOG4105ERH Fumarylacetoacetate hydrolase FOC96_RS03630 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC96_RS03660 ENOG410667J hydrolase FOC96_RS03665 ENOG4108JQ7 (ABC) transporter FOC96_RS03670 ENOG4105C3U ABC transporter FOC96_RS03675 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC96_RS03685 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC96_RS03700 ENOG4105C5H ABC transporter FOC96_RS03725 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC96_RS03745 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC96_RS03765 ENOG4105F6E Acyl-transferase FOC96_RS03795 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC96_RS03800 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC96_RS03805 ENOG4105E0C molybdate abc transporter FOC96_RS03815 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC96_RS03820 ENOG4105II7 pyrroline-5-carboxylate reductase FOC96_RS03830 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC96_RS03835 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC96_RS03845 ENOG4105U5Y Transcriptional regulator FOC96_RS03870 ENOG4108JQ7 (ABC) transporter FOC96_RS03875 ENOG4105C3U ABC transporter FOC96_RS03880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC96_RS03885 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC96_RS03900 ENOG4105C2C drug resistance transporter, Bcr CflA FOC96_RS03915 ENOG4105IQ5 FAD linked oxidase domain protein FOC96_RS03930 ENOG4105D01 (LipO)protein FOC96_RS03935 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC96_RS03940 ENOG4108UMI ABC transporter, permease FOC96_RS03945 ENOG4108PSK reductase FOC96_RS03980 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC96_RS03990 ENOG4105CMG Carbohydrate kinase FOC96_RS04025 ENOG4107U5W ybbr family FOC96_RS04030 ENOG4105C8B TIGR00159 family FOC96_RS04110 ENOG4108NMV polysaccharide deacetylase FOC96_RS04125 ENOG4105D1F ATP-binding protein FOC96_RS04155 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC96_RS04200 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC96_RS04210 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC96_RS04340 ENOG4105XPM ribosomal protein FOC96_RS04355 ENOG4107Y49 methyltransferase FOC96_RS04380 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC96_RS04395 ENOG4105QIV RNA polymerase FOC96_RS04400 ENOG4105M0M Tetracycline resistance protein FOC96_RS04405 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC96_RS04420 ENOG4105D7W serine acetyltransferase FOC96_RS04440 ENOG4105CTP PilT protein domain protein FOC96_RS04450 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC96_RS04465 ENOG4108Z0C Uvrb UvrC protein FOC96_RS04555 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC96_RS04565 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC96_RS04570 ENOG4105KRF dihydroneopterin aldolase FOC96_RS04575 ENOG4105EEI dihydropteroate synthase FOC96_RS04580 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC96_RS04585 ENOG4105DDQ anthranilate synthase FOC96_RS04590 ENOG4105CRQ synthase (Component I) FOC96_RS04595 ENOG4105C6T cysteine synthase FOC96_RS04610 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC96_RS04615 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC96_RS04640 ENOG41060GV RNA binding s1 domain protein FOC96_RS04655 ENOG4105VYY sporulation protein yabp FOC96_RS04660 ENOG41082I2 s4 domain protein FOC96_RS04665 ENOG4108IY2 MazG family FOC96_RS04675 ENOG4108M14 stage v sporulation protein t FOC96_RS04680 ENOG4108JA2 transcriptioN-repair coupling factor FOC96_RS04710 ENOG4105KME endoribonuclease L-psp FOC96_RS04715 ENOG4105DFT pur operon repressor FOC96_RS04730 ENOG4105W42 Veg protein FOC96_RS04735 ENOG4105XFA sporulation peptidase YabG FOC96_RS04745 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC96_RS04750 ENOG4105F8V Hydrolase, tatD family FOC96_RS04760 ENOG4105KRN Transcriptional regulator, abrb family FOC96_RS04765 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC96_RS04775 ENOG41060K3 Methyltransferase FOC96_RS04785 ENOG4105MA4 psp1 domain protein FOC96_RS04790 ENOG4105FA2 dna polymerase iii FOC96_RS04800 ENOG4105CXN decarboxylase FOC96_RS04835 ENOG41067KS pro-sigma K processing FOC96_RS04855 ENOG4105C6E dna polymerase iii FOC96_RS04865 ENOG4108Z6B deaminase FOC96_RS04870 ENOG4105GTG Isochorismatase FOC96_RS04880 ENOG4105ZMH deoxynucleoside kinase FOC96_RS04915 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC96_RS04950 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC96_RS04965 ENOG410848D S4 domain protein YaaA FOC96_RS04970 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC96_RS04990 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC96_RS05020 ENOG4107QJE Chromosome Partitioning Protein FOC96_RS05025 ENOG4105FA0 parb-like partition protein FOC96_RS05030 ENOG4108ZDA Sporulation protein YyaC FOC96_RS05035 ENOG4105D8X mechanosensitive ion channel FOC96_RS05040 ENOG4105VDK protein, conserved in bacteria FOC96_RS05045 ENOG4105C3G gtp-binding protein FOC96_RS05055 ENOG4108UUM single-stranded DNA-binding protein FOC96_RS05065 ENOG4108XMW Membrane FOC96_RS05070 ENOG4105BZR domain protein FOC96_RS05080 ENOG4105CDU Replicative dna helicase FOC96_RS05110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS05115 ENOG4105BZU Histidine kinase FOC96_RS05130 ENOG4105Q2H domain protein FOC96_RS05135 ENOG4105C0H protease FOC96_RS05165 ENOG4105DPN Oligoendopeptidase f FOC96_RS05180 ENOG4105C1J atp-dependent rna helicase FOC96_RS05190 ENOG4108UT2 hemolysin iii FOC96_RS05195 ENOG4105CMR udp-glucose 4-epimerase FOC96_RS05205 ENOG4105IW1 AmiS UreI transporter FOC96_RS05215 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC96_RS05230 ENOG4107RGD Major Facilitator superfamily FOC96_RS05235 ENOG4108HRK Histidine kinase FOC96_RS05240 ENOG4105DY9 regulatoR FOC96_RS05255 ENOG4106F5Q Membrane FOC96_RS05260 ENOG4105E0X reductase FOC96_RS05270 ENOG41067SE Tetr family transcriptional regulator FOC96_RS05275 ENOG4105CKK Glycosyl transferase, family 2 FOC96_RS05295 ENOG4105C5H ABC transporter FOC96_RS05300 ENOG4105JEU Glycosyl transferase, family 2 FOC96_RS05310 ENOG4108S4H thioesterase Superfamily protein FOC96_RS05320 ENOG4106YBV Methyl-accepting chemotaxis FOC96_RS05325 ENOG4105EN6 Membrane FOC96_RS05345 ENOG41079KZ Major Facilitator Superfamily FOC96_RS05350 ENOG4105DY9 regulatoR FOC96_RS05355 ENOG4105D22 carbon starvation protein FOC96_RS05360 ENOG4105VCD cytoplasmic protein FOC96_RS05365 ENOG4105BZU Histidine kinase FOC96_RS05370 ENOG4105DWF phosphomethylpyrimidine kinase FOC96_RS05375 ENOG4105BZU Histidine kinase FOC96_RS05380 ENOG4105WH1 Two component transcriptional regulator luxr family FOC96_RS05390 ENOG4108Y4K DNA-binding transcriptional activator FOC96_RS05395 ENOG4105D7V transposase FOC96_RS05420 ENOG4105D6E homoserine dehydrogenase FOC96_RS05435 ENOG41090WU lipolytic protein G-D-S-L family FOC96_RS05440 ENOG4105CJ1 ABC, transporter FOC96_RS05445 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC96_RS05455 ENOG4105VCH membrane FOC96_RS05460 ENOG410667J hydrolase FOC96_RS05470 ENOG4107SVH Potassium channel protein FOC96_RS05490 ENOG4108VKI Cell wall hydrolase FOC96_RS05505 ENOG4108IJ2 phosphate acetyltransferase FOC96_RS05520 ENOG4108VCI transcription factor, rsfa family FOC96_RS05530 ENOG4105DQ5 transport system permease protein FOC96_RS05535 ENOG4105EHG Permease protein FOC96_RS05540 ENOG4105E0A ABC, transporter FOC96_RS05545 ENOG4108MES Periplasmic binding protein FOC96_RS05550 ENOG4105DCI Phosphohydrolase FOC96_RS05555 ENOG41069HH 4-oxalocrotonate tautomerase FOC96_RS05560 ENOG4108Z4T Peptidase M50 FOC96_RS05565 ENOG4108XFG YwhD family FOC96_RS05570 ENOG4105BZ4 penicillin-binding protein FOC96_RS05575 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC96_RS05580 ENOG4107SWG transcriptional regulator MERR family FOC96_RS05585 ENOG4105DXB Major Facilitator superfamily FOC96_RS05595 ENOG4105CYW agmatinase FOC96_RS05615 ENOG410684U Domain of unknown function (DUF1934) FOC96_RS05625 ENOG4105EMN RNA polymerase sigma factor FOC96_RS05645 ENOG4105IIU Aminopeptidase FOC96_RS05655 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC96_RS05660 ENOG4108M15 ABC transporter FOC96_RS05665 ENOG4105KCT ABC transporter FOC96_RS05670 ENOG4105BZU Histidine kinase FOC96_RS05695 ENOG4105BZU Histidine kinase FOC96_RS05750 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) FOC96_RS05755 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC96_RS05795 ENOG41067QW Transcriptional regulator FOC96_RS05800 ENOG4105DF6 Fe-S oxidoreductase FOC96_RS05810 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC96_RS05815 ENOG4105C1G acyl-Coa dehydrogenase FOC96_RS05820 ENOG4105C1G acyl-Coa dehydrogenase FOC96_RS05860 ENOG4105CBT Fructose-1,6-bisphosphatase FOC96_RS05865 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC96_RS05885 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC96_RS05890 ENOG4108ZXQ stage ii sporulation protein r FOC96_RS05900 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC96_RS05915 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC96_RS05920 ENOG4108VGI doxx family FOC96_RS05935 ENOG4108YZG isomerase FOC96_RS05965 ENOG41062M3 atp synthase FOC96_RS05970 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC96_RS06020 ENOG4105BZU Histidine kinase FOC96_RS06035 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC96_RS06065 ENOG4105D65 subunit l FOC96_RS06070 ENOG4105C8S subunit m FOC96_RS06075 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC96_RS06080 ENOG4106778 Protein of unknown function (DUF1146) FOC96_RS06100 ENOG4105DY9 regulatoR FOC96_RS06115 ENOG4105FRN stage II sporulation protein FOC96_RS06125 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC96_RS06140 ENOG4107YJ4 chain length determinant protein FOC96_RS06145 ENOG4105HTX biosynthesis protein FOC96_RS06150 ENOG4107YJ4 chain length determinant protein FOC96_RS06155 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC96_RS06160 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC96_RS06165 ENOG4105D3Q Sugar transferase FOC96_RS06195 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC96_RS06200 ENOG4105CMR udp-glucose 4-epimerase FOC96_RS06215 ENOG4105CMR udp-glucose 4-epimerase FOC96_RS06220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS06240 ENOG4105CXY transporter FOC96_RS06260 ENOG4105C19 ABC transporter FOC96_RS06265 ENOG4107RBB ABC transporter, permease FOC96_RS06280 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC96_RS06310 ENOG4105C0D helicase FOC96_RS06315 ENOG4105KBK Zinc finger, swim domain protein FOC96_RS06340 ENOG41069ER domain protein FOC96_RS06345 ENOG4105C94 Transporter FOC96_RS06350 ENOG4107R8N Glycosyl transferase, family 2 FOC96_RS06375 ENOG4105E0M Sulfatase FOC96_RS06385 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC96_RS06395 ENOG4105D7V transposase FOC96_RS06400 ENOG4105DAA L-lactate FOC96_RS06435 ENOG4107RSM transcriptional regulator FOC96_RS06440 ENOG4105ECB domain protein FOC96_RS06460 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC96_RS06475 ENOG4105VZJ PTS System FOC96_RS06485 ENOG4105VCP PTS System FOC96_RS06505 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC96_RS06515 ENOG4105CK1 PTS System FOC96_RS06520 ENOG4105VCP PTS System FOC96_RS06525 ENOG4105F8D glycoside hydrolase family 4 FOC96_RS06545 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC96_RS06555 ENOG4105ESV Glycosyl transferase, family 4 FOC96_RS06560 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC96_RS06565 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC96_RS06570 ENOG4108KGH TRANSCRIPTIONal FOC96_RS06575 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC96_RS06585 ENOG4105KVH Transcriptional regulator FOC96_RS06600 ENOG41081UC Inherit from COG: Competence protein FOC96_RS06605 ENOG4105VEQ Cold shock protein FOC96_RS06610 ENOG4105MS2 ribosomal subunit Interface protein FOC96_RS06630 ENOG4105CAK Cell division ATP-binding protein ftsE FOC96_RS06635 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC96_RS06640 ENOG4105CN1 protease FOC96_RS06650 ENOG4105BZ1 (ABC) transporter FOC96_RS06660 ENOG4105C5H ABC transporter FOC96_RS06665 ENOG4108WS4 fmn reductase FOC96_RS06675 ENOG4105DUM transcriptional regulator, lysR family FOC96_RS06680 ENOG4105HMI Membrane FOC96_RS06705 ENOG4107TXC Transcriptional regulator FOC96_RS06720 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC96_RS06725 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC96_RS06735 ENOG41086DT Membrane protein of unknown function FOC96_RS06755 ENOG4108S4C acetyltransferase FOC96_RS06765 ENOG4105C3M thioredoxin reductase FOC96_RS06775 ENOG4108Z4K mutator MutT protein FOC96_RS06785 ENOG4105CHW UPF0052 protein FOC96_RS06795 ENOG4105KRI phosphocarrier protein (HPr FOC96_RS06805 ENOG4105H67 Protein of unknown function (DUF421) FOC96_RS06820 ENOG4105CZ3 stage V sporulation protein ad FOC96_RS06825 ENOG41090VF Stage v sporulation protein ac FOC96_RS06845 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC96_RS06895 ENOG41067MG lrgb family FOC96_RS06900 ENOG4105XZU Preprotein translocase, subunit SecG FOC96_RS06910 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC96_RS06935 ENOG4105DUX Transporter FOC96_RS07010 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FOC96_RS07020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS07035 ENOG4105CM4 permease protein FOC96_RS07040 ENOG4108IPW abc transporter atp-binding protein FOC96_RS07070 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC96_RS07075 ENOG4105C5H ABC transporter FOC96_RS07100 ENOG4105WMR Protein CrcB homolog FOC96_RS07110 ENOG4105C8Q Methyl-accepting chemotaxis FOC96_RS07125 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC96_RS07140 ENOG4105KVH Transcriptional regulator FOC96_RS07145 ENOG4105F27 Major Facilitator FOC96_RS07150 ENOG4105CV8 reductase FOC96_RS07165 ENOG4108RYK Nad-dependent epimerase dehydratase FOC96_RS07180 ENOG4105D9N nucleoside FOC96_RS07185 ENOG4105D9N nucleoside FOC96_RS07205 ENOG4108URH decarboxylase FOC96_RS07220 ENOG4108RMU ferritin dps family protein FOC96_RS07230 ENOG4105NCW Trka-c domain protein FOC96_RS07235 ENOG4107S91 Sodium hydrogen exchanger FOC96_RS07255 ENOG4105D4Y metalloprotease FOC96_RS07260 ENOG4105VG1 fes assembly suf system protein FOC96_RS07265 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC96_RS07270 ENOG4105C8Q Methyl-accepting chemotaxis FOC96_RS07290 ENOG4105BZU Histidine kinase FOC96_RS07295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS07300 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC96_RS07310 ENOG4107ZTW SNARE associated Golgi FOC96_RS07345 ENOG4107AYK membrAne FOC96_RS07355 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC96_RS07370 ENOG4107R7I amino acid FOC96_RS07375 ENOG4108SUT Major Facilitator Superfamily FOC96_RS07395 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC96_RS07415 ENOG4105DZ1 carboxypeptidase FOC96_RS07430 ENOG4105CHU acetyl-coa acetyltransferase FOC96_RS07435 ENOG4105C1G acyl-Coa dehydrogenase FOC96_RS07460 ENOG4108IUW ABC transporter FOC96_RS07470 ENOG4108W8B Beta-lactamase domain protein FOC96_RS07480 ENOG4108IMY Transcriptional regulator FOC96_RS07505 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC96_RS07560 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC96_RS07590 ENOG4108UMI ABC transporter, permease FOC96_RS07595 ENOG4105D01 (LipO)protein FOC96_RS07600 ENOG4105D01 (LipO)protein FOC96_RS07605 ENOG4105C3K feS assembly ATPase SufC FOC96_RS07610 ENOG4105JRK feS assembly protein SufD FOC96_RS07615 ENOG4105C9B Cysteine desulfurase FOC96_RS07620 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC96_RS07625 ENOG4105DIW FeS assembly protein SUFB FOC96_RS07640 ENOG4107R8B 5'-nucleotidase FOC96_RS07645 ENOG4105KZD Domain of unknown function (DUF1805) FOC96_RS07655 ENOG4105FAA peptidase M23 FOC96_RS07680 ENOG41090T1 Membrane FOC96_RS07685 ENOG4107TXC Transcriptional regulator FOC96_RS07690 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC96_RS07695 ENOG4105MMD transcriptional regulator FOC96_RS07710 ENOG4105CBT Fructose-1,6-bisphosphatase FOC96_RS07725 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC96_RS07735 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC96_RS07740 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC96_RS07755 ENOG4108W5N phosphatidylglycerophosphatase a FOC96_RS07770 ENOG41083MR nifu domain-containing protein FOC96_RS07795 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC96_RS07800 ENOG4105C4B ABC transporter, permease FOC96_RS07805 ENOG4108JJA ABC, transporter FOC96_RS07830 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC96_RS07840 ENOG4105EWC Purine nucleoside phosphorylase FOC96_RS07870 ENOG4105CEP NADH dehydrogenase FOC96_RS07885 ENOG41069ER domain protein FOC96_RS07905 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC96_RS07920 ENOG4105KA0 thioesterase Superfamily protein FOC96_RS07940 ENOG4107R3E Citrate transporter FOC96_RS07950 ENOG4105Y38 Kinase-associated protein B FOC96_RS07965 ENOG4105C87 Aminotransferase class I and II FOC96_RS07975 ENOG4108MUZ hydrolase FOC96_RS07980 ENOG4105C5I Dehydrogenase FOC96_RS07985 ENOG4108ZB6 transcriptional regulator AsnC family FOC96_RS07990 ENOG4105CHM Aminotransferase FOC96_RS08000 ENOG4105WG9 Conserved Protein FOC96_RS08015 ENOG4107PBV potassium channel FOC96_RS08020 ENOG4105KT7 mgtC SapB transporter FOC96_RS08055 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC96_RS08155 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC96_RS08200 ENOG4105VEQ Cold shock protein FOC96_RS08210 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC96_RS08215 ENOG4105E4F Isochorismate synthase FOC96_RS08225 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC96_RS08230 ENOG4108IPT Naphthoate synthase FOC96_RS08240 ENOG4105DTQ mandelate racemase muconate lactonizing FOC96_RS08260 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC96_RS08285 ENOG4105C6Z Gluconate FOC96_RS08325 ENOG41086D8 Transcriptional regulator FOC96_RS08330 ENOG4105C19 ABC transporter FOC96_RS08345 ENOG4107ZTW SNARE associated Golgi FOC96_RS08365 ENOG4105D7V transposase FOC96_RS08375 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC96_RS08380 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC96_RS08405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS08410 ENOG4105BZU Histidine kinase FOC96_RS08415 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FOC96_RS08480 ENOG41087YS Phage shock protein A FOC96_RS08525 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC96_RS08530 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC96_RS08535 ENOG4108V2W Carbonate dehydratase FOC96_RS08575 ENOG4107XGZ Hydrolase FOC96_RS08590 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC96_RS08600 ENOG4105D2X ABC transporter substrate-binding protein FOC96_RS08615 ENOG4107T7U Sulfatase FOC96_RS08620 ENOG4107S9D Alpha beta hydrolase FOC96_RS08625 ENOG4105BZU Histidine kinase FOC96_RS08630 ENOG4105BZU Histidine kinase FOC96_RS08640 ENOG4105E98 transcriptional regulator DeoR family FOC96_RS08645 ENOG4107XGZ Hydrolase FOC96_RS08710 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC96_RS08720 ENOG4105BZF Glycosyl transferase (Group 1 FOC96_RS08725 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC96_RS08730 ENOG4108Z0R Transferase FOC96_RS08735 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC96_RS08780 ENOG4105CIG ABC transporter FOC96_RS08790 ENOG4105N5T Radical SAM Protein FOC96_RS08810 ENOG4105C19 ABC transporter FOC96_RS08825 ENOG4105NCW Trka-c domain protein FOC96_RS08830 ENOG4107S91 Sodium hydrogen exchanger FOC96_RS08835 ENOG410605W Major Facilitator FOC96_RS08870 ENOG4108B31 Spore germination protein FOC96_RS08880 ENOG4105DWV Homoserine O-trans-acetylase FOC96_RS08890 ENOG41085GJ domain protein FOC96_RS08910 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC96_RS08915 ENOG4105D06 uba thif-type nad fad binding protein FOC96_RS08925 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC96_RS08930 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC96_RS08935 ENOG4108ZAF Molybdopterin FOC96_RS08955 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC96_RS08960 ENOG4108VJ1 Transcriptional regulator (CarD family FOC96_RS08995 ENOG4105CBX hi0933 family FOC96_RS09010 ENOG4105YW5 deoR family transcriptional regulator FOC96_RS09015 ENOG4107QSE Dipeptidase FOC96_RS09025 ENOG4108IUM Glycogen debranching enzyme FOC96_RS09030 ENOG4108V15 phosphotransferase enzyme family FOC96_RS09045 ENOG4105C8F Beta-lactamase domain protein FOC96_RS09075 ENOG4108VDD TRNA binding domain protein FOC96_RS09105 ENOG4105K7K Transcriptional regulator FOC96_RS09150 ENOG4105C88 aminopeptidase FOC96_RS09170 ENOG4105ETE Transcriptional regulator (LacI family FOC96_RS09200 ENOG4105EP9 oxidoreductase FOC96_RS09205 ENOG4107SNB ankyrin repeat protein YahD FOC96_RS09215 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC96_RS09230 ENOG4105DGU Histone deacetylase FOC96_RS09235 ENOG4105W87 Cbs domain FOC96_RS09240 ENOG4105F1V Acetoin utilization protein FOC96_RS09255 ENOG4105EMN RNA polymerase sigma factor FOC96_RS09305 ENOG4105C28 cystathionine FOC96_RS09315 ENOG4105U5Y Transcriptional regulator FOC96_RS09325 ENOG4106KR7 LysR family Transcriptional regulator FOC96_RS09350 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC96_RS09360 ENOG4105EFZ amidohydrolase FOC96_RS09375 ENOG4105KBJ sporulation protein ytfj FOC96_RS09380 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC96_RS09405 ENOG4108JYZ YitT family FOC96_RS09455 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC96_RS09465 ENOG4107YZX Universal stress protein FOC96_RS09485 ENOG4105VZ8 Transcriptional regulator FOC96_RS09495 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC96_RS09540 ENOG4105DC7 peptidase M24 FOC96_RS09575 ENOG4105SFS phosphoesterase RecJ domain protein FOC96_RS09585 ENOG4105VV2 FOC96_RS09590 ENOG4105C0B DNA polymerase III (alpha subunit) FOC96_RS09595 ENOG4105C6K Malic enzyme FOC96_RS09600 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC96_RS09625 ENOG4105FS0 cytoplasmic membrane protein FOC96_RS09630 ENOG4108REF Sporulation integral membrane protein ytvi FOC96_RS09640 ENOG4105BZN citrate synthase FOC96_RS09645 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC96_RS09665 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC96_RS09670 ENOG4105BZU Histidine kinase FOC96_RS09675 ENOG4105C2M dna polymerase I FOC96_RS09690 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC96_RS09695 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC96_RS09720 ENOG4108TDW sporulation protein YtxC FOC96_RS09725 ENOG4105C22 threonyL-tRNA synthetase FOC96_RS09750 ENOG4105CN9 Peptidase m42 family protein FOC96_RS09755 ENOG4108JGH Tetr family transcriptional regulator FOC96_RS09760 ENOG4105CW7 secretion protein, HlyD family FOC96_RS09765 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC96_RS09810 ENOG4108RWN rrna methyltransferase FOC96_RS09860 ENOG4105DCG PHP domain protein FOC96_RS09870 ENOG4105FE9 pseudouridine synthase FOC96_RS09880 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC96_RS09885 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC96_RS09900 ENOG4105E0A ABC, transporter FOC96_RS09905 ENOG4105KFN sortase, SrtB family FOC96_RS09920 ENOG4105DR4 Methyltransferase FOC96_RS09935 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC96_RS09975 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC96_RS09980 ENOG4105J76 Periplasmic binding protein FOC96_RS09990 ENOG4105CEY Amp-dependent synthetase and ligase FOC96_RS09995 ENOG4107Z3H Transcriptional regulator, TetR family FOC96_RS10000 ENOG41060WC Enoyl-CoA hydratase FOC96_RS10005 ENOG4105BZJ Electron transfer flavoprotein FOC96_RS10010 ENOG4105C10 Electron transfer flavoprotein FOC96_RS10015 ENOG4105K63 Thioredoxin FOC96_RS10030 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC96_RS10040 ENOG4105E33 succinate dehydrogenase FOC96_RS10050 ENOG4108VXD carboxy-peptidase FOC96_RS10055 ENOG4105E14 MotA TolQ exbB proton channel FOC96_RS10060 ENOG4105ER2 Ompa motb domain protein FOC96_RS10065 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC96_RS10070 ENOG4108IUX (ABC) transporter FOC96_RS10075 ENOG4105RHA ABC transporter, permease FOC96_RS10080 ENOG4108Z40 Transcriptional regulator FOC96_RS10085 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC96_RS10095 ENOG4108JCI Transcriptional regulator FOC96_RS10105 ENOG4105DZC cytosine deaminase FOC96_RS10115 ENOG4105PFC Transcriptional regulator FOC96_RS10130 ENOG4105KBX Transcriptional regulator, TetR family FOC96_RS10140 ENOG4108PCX Major Facilitator FOC96_RS10150 ENOG4108XJQ germination protein FOC96_RS10165 ENOG4105M59 Phosphodiesterase, mj0936 family FOC96_RS10180 ENOG4108QCI YvbH-like oligomerisation region FOC96_RS10210 ENOG4108IUQ atp-dependent protease FOC96_RS10230 ENOG4105K56 Transcriptional regulator FOC96_RS10255 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC96_RS10265 ENOG41068KH stage VI sporulation protein D FOC96_RS10280 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC96_RS10300 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC96_RS10335 ENOG4105ED2 Beta-lactamase FOC96_RS10415 ENOG4105DFF Rod shape-determining protein mreb FOC96_RS10435 ENOG4107QMS site-determining protein FOC96_RS10450 ENOG4105C03 ribonuclease FOC96_RS10460 ENOG4105X36 (ribosomal) protein FOC96_RS10485 ENOG4105EWM Histidine kinase FOC96_RS10505 ENOG4105CQC Prephenate dehydratase FOC96_RS10510 ENOG4108RPX mosc domain containing protein FOC96_RS10525 ENOG4108IYU L-aspartate oxidase FOC96_RS10530 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC96_RS10555 ENOG41082BM Transcriptional regulator, arsr family FOC96_RS10560 ENOG4108IPJ Membrane FOC96_RS10570 ENOG4108HUF Transporter FOC96_RS10585 ENOG41061AI Protein of unknown function (DUF2905) FOC96_RS10600 ENOG4105VIE preprotein translocase, subunit YajC FOC96_RS10610 ENOG4108QG2 Membrane FOC96_RS10615 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC96_RS10625 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC96_RS10630 ENOG41076HS cation diffusion facilitator family transporter FOC96_RS10635 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC96_RS10645 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC96_RS10670 ENOG4105CUZ uba thif-type nad fad binding protein FOC96_RS10675 ENOG4108VCI transcription factor, rsfa family FOC96_RS10680 ENOG4105D1H recombination factor protein RarA FOC96_RS10690 ENOG4105C3J Cysteine desulfurase FOC96_RS10705 ENOG4105C7H Helicase, RecD TraA family FOC96_RS10710 ENOG41060CR FOC96_RS10725 ENOG4105C02 permease FOC96_RS10755 ENOG4105HHA aminodeoxychorismate lyase FOC96_RS10765 ENOG4105XYU peptidase (U32 family) FOC96_RS10770 ENOG4105CFP Peptidase U32 FOC96_RS10785 ENOG4107XRG penicillin-binding protein FOC96_RS10815 ENOG4105C28 cystathionine FOC96_RS10820 ENOG4105C0A alcohol dehydrogenase FOC96_RS10830 ENOG4108V5C ABC transporter FOC96_RS10835 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC96_RS10875 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC96_RS10885 ENOG4105MIR Phenylalanine 4-monooxygenase FOC96_RS10890 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC96_RS10925 ENOG4108MUZ hydrolase FOC96_RS10935 ENOG4105G6Z alkaline phosphatase FOC96_RS10950 ENOG4108TVJ Nitroreductase FOC96_RS10970 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC96_RS10985 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC96_RS10990 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC96_RS11000 ENOG410812S Rna-binding protein FOC96_RS11010 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC96_RS11020 ENOG4105DXX methyltransferase FOC96_RS11030 ENOG4105KQC Competence protein FOC96_RS11035 ENOG4108UK2 deaminase FOC96_RS11040 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC96_RS11050 ENOG4105TQK DNA polymerase iii, delta' subunit FOC96_RS11075 ENOG4105KVH Transcriptional regulator FOC96_RS11080 ENOG4105CSA Coproporphyrinogen iii oxidase FOC96_RS11110 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC96_RS11115 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC96_RS11125 ENOG4105KTH gatB Yqey FOC96_RS11130 ENOG41068P3 sporulation protein YqfC FOC96_RS11140 ENOG4105C9A Phoh family FOC96_RS11145 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC96_RS11155 ENOG4107YR5 Diacylglycerol kinase FOC96_RS11160 ENOG4105KG3 cytidine deaminase FOC96_RS11165 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC96_RS11195 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC96_RS11200 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC96_RS11215 ENOG4105EGD dinuclear metal center protein, YbgI family FOC96_RS11240 ENOG41069ZM Protein of unknown function (DUF2624) FOC96_RS11245 ENOG4108JYZ YitT family FOC96_RS11250 ENOG4105FDK ABC transporter FOC96_RS11260 ENOG4105N80 Ferric uptake regulator, Fur family FOC96_RS11285 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC96_RS11295 ENOG4107RF6 penicillin-binding protein FOC96_RS11300 ENOG4105PWN phosphate abc transporter FOC96_RS11305 ENOG4105C8U phosphate abc transporter FOC96_RS11310 ENOG4105E2Z phosphate ABC transporter (Permease FOC96_RS11320 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC96_RS11335 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC96_RS11345 ENOG4105DKQ ROK family FOC96_RS11355 ENOG4105C5X domain protein FOC96_RS11375 ENOG4105C28 cystathionine FOC96_RS11380 ENOG4105C28 cystathionine FOC96_RS11390 ENOG4105C3R Methionine synthase FOC96_RS11520 ENOG4105C0D helicase FOC96_RS11550 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC96_RS11555 ENOG4105CJ1 ABC, transporter FOC96_RS11590 ENOG41080TC multidrug resistance protein FOC96_RS11610 ENOG4105WZW rhodanese family FOC96_RS11615 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC96_RS11630 ENOG4105K7K Transcriptional regulator FOC96_RS11645 ENOG4107YBY Hydrolase FOC96_RS11655 ENOG4105CBJ Metal-dependent enzyme FOC96_RS11670 ENOG4105DC7 peptidase M24 FOC96_RS11695 ENOG4105CD2 stage iii sporulation protein aa FOC96_RS11700 ENOG4105KR5 Stage iii sporulation protein FOC96_RS11705 ENOG4108CQH stage III sporulation protein AC FOC96_RS11710 ENOG4105KQ4 Stage iii sporulation protein ad FOC96_RS11720 ENOG410644B Stage III sporulation protein af FOC96_RS11745 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC96_RS11750 ENOG4108ZSR alkaline shock protein FOC96_RS11775 ENOG4105CTB Polyprenyl synthetase FOC96_RS11785 ENOG4105DX0 Hemolysin A FOC96_RS11795 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC96_RS11800 ENOG4105S1Z Stage IV sporulation protein B FOC96_RS11805 ENOG4107QQR Sporulation FOC96_RS11820 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC96_RS11830 ENOG4108JUB Transcriptional regulator FOC96_RS11840 ENOG4107RDP Dehydrogenase FOC96_RS11860 ENOG4105CPP Dehydrogenase, E1 component FOC96_RS11865 ENOG4105C7S Dehydrogenase FOC96_RS11875 ENOG4105E09 nadh pyrophosphatase FOC96_RS11880 ENOG4105G7B Protein of unknown function (DUF2992) FOC96_RS11890 ENOG4108HW3 (ABC) transporter FOC96_RS11895 ENOG4105E5Q amino acid AbC transporter FOC96_RS11900 ENOG4105CDA abc transporter atp-binding protein FOC96_RS11905 ENOG4108QEG Membrane FOC96_RS11910 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC96_RS11925 ENOG4105D9U N-acetyltransferase FOC96_RS11930 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC96_RS11940 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC96_RS11965 ENOG4105EJQ L-serine dehydratase FOC96_RS11970 ENOG4105II7 pyrroline-5-carboxylate reductase FOC96_RS11975 ENOG41069FQ Metallo-beta-lactamase superfamily FOC96_RS11980 ENOG4108IXY short-chain dehydrogenase reductase FOC96_RS11995 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC96_RS12035 ENOG4105CGH 5'-nucleotidase FOC96_RS12040 ENOG4105DFD Na H antiporter FOC96_RS12050 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC96_RS12065 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC96_RS12070 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC96_RS12095 ENOG4108R6K riboflavin synthase, subunit alpha FOC96_RS12100 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC96_RS12120 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC96_RS12125 ENOG4105ETE Transcriptional regulator (LacI family FOC96_RS12135 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC96_RS12155 ENOG4105RHY Pfam:UPF0157 FOC96_RS12165 ENOG4105CPC Aldo Keto reductase FOC96_RS12185 ENOG4105MZ9 stage II sporulation protein m FOC96_RS12190 ENOG4105I3K Ferric uptake regulator, Fur family FOC96_RS12200 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC96_RS12225 ENOG4105D7N magnesium and cobalt transport protein CorA FOC96_RS12255 ENOG4105DVE abc transporter atp-binding protein FOC96_RS12260 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC96_RS12265 ENOG4105DZ1 carboxypeptidase FOC96_RS12270 ENOG41082AN stage II sporulation protein FOC96_RS12280 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC96_RS12285 ENOG4105C8J )-transporter FOC96_RS12305 ENOG41090VF Stage v sporulation protein ac FOC96_RS12310 ENOG4105CZ3 stage V sporulation protein ad FOC96_RS12320 ENOG4105G6R Stage v sporulation protein ae FOC96_RS12330 ENOG4105J7I hydrolase FOC96_RS12335 ENOG4105PTM secreted protein FOC96_RS12340 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC96_RS12375 ENOG4105CE4 GlcNAc 6-P deacetylase FOC96_RS12395 ENOG4105CID antiterminator FOC96_RS12410 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC96_RS12430 ENOG4105BZU Histidine kinase FOC96_RS12435 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC96_RS12475 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC96_RS12495 ENOG4105DTD Dehydrogenase FOC96_RS12500 ENOG4105K7K Transcriptional regulator FOC96_RS12530 ENOG4105CHU acetyl-coa acetyltransferase FOC96_RS12580 ENOG4105CG3 alpha amylase, catalytic region FOC96_RS12590 ENOG4107FKK extracellular solute-binding protein family 1 FOC96_RS12600 ENOG4105EG2 ABC transporter, permease FOC96_RS12605 ENOG4105FKQ transcriptional regulator FOC96_RS12610 ENOG4105CHM Aminotransferase FOC96_RS12620 ENOG4108HGU Histidine kinase FOC96_RS12675 ENOG4105UIN FOC96_RS12685 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC96_RS12700 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC96_RS12705 ENOG4105EPM Diguanylate phosphodiesterase FOC96_RS12720 ENOG4107IN1 Protein of unknown function (DUF1797) FOC96_RS12730 ENOG4108XRC Protein of unknown function (DUF458) FOC96_RS12765 ENOG4107ZYR domain protein FOC96_RS12770 ENOG4105CN5 Metallo-Beta-Lactamase FOC96_RS12780 ENOG4108X4Q Hydrolase FOC96_RS12785 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC96_RS12800 ENOG4105CPP Dehydrogenase, E1 component FOC96_RS12850 ENOG4105CXN decarboxylase FOC96_RS12870 ENOG4105ECY inositol monophosphatase FOC96_RS12880 ENOG4105CI3 gtp-binding protein typa FOC96_RS12885 ENOG4105QA2 FOC96_RS12905 ENOG4108IAB Phoh family FOC96_RS12920 ENOG4105CNI cell division protein FtsW FOC96_RS12925 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC96_RS12975 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC96_RS12990 ENOG4107TB6 phosphoglycerate mutase FOC96_RS13010 ENOG4106H78 methyltransferase FOC96_RS13020 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC96_RS13025 ENOG4105D78 K07001 NTE family protein FOC96_RS13030 ENOG41063PX domain protein FOC96_RS13040 ENOG4105KNH Nucleic acid-binding protein FOC96_RS13075 ENOG41068DC Essential cell division protein (By similarity) FOC96_RS13080 ENOG4105CJN penicillin-binding protein FOC96_RS13085 ENOG4105CJN penicillin-binding protein FOC96_RS13090 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC96_RS13105 ENOG4105CNI cell division protein FtsW FOC96_RS13115 ENOG4105D4A Cell wall formation (By similarity) FOC96_RS13120 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC96_RS13125 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC96_RS13130 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC96_RS13140 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC96_RS13150 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC96_RS13155 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC96_RS13160 ENOG4105DFA alanine racemase domain protein FOC96_RS13170 ENOG41067XK integral membrane protein FOC96_RS13175 ENOG4105DBK s4 domain protein FOC96_RS13200 ENOG4105C34 Pseudouridine synthase FOC96_RS13285 ENOG4105DC7 peptidase M24 FOC96_RS13300 ENOG4105DSJ YicC domain protein FOC96_RS13320 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC96_RS13325 ENOG4105C25 Primosomal protein n' FOC96_RS13330 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC96_RS13340 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC96_RS13350 ENOG4108ZF3 Phosphatase FOC96_RS13355 ENOG4105D9P serine threonine protein kinase FOC96_RS13360 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC96_RS13365 ENOG4105DJV ribulose-phosphate 3-epimerase FOC96_RS13370 ENOG4105FJ0 thiamine FOC96_RS13385 ENOG4108ZAA Alkaline-shock protein FOC96_RS13390 ENOG4105DP4 dak2 domain fusion protein ylov FOC96_RS13395 ENOG4105CB5 ATP-dependent DNA helicase recG FOC96_RS13410 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC96_RS13415 ENOG4105CHR reductase FOC96_RS13430 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC96_RS13435 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC96_RS13455 ENOG4105VB6 UPF0109 protein FOC96_RS13480 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC96_RS13495 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC96_RS13500 ENOG4105C79 DNA protecting protein DprA FOC96_RS13505 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC96_RS13515 ENOG4108HE4 integrase family FOC96_RS13560 ENOG4105KNE Phosphatidate cytidylyltransferase FOC96_RS13570 ENOG4105DZP Membrane-associated zinc metalloprotease FOC96_RS13585 ENOG4105EKQ RNA-directed DNA polymerase FOC96_RS13590 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC96_RS13600 ENOG4105CHV Transcription elongation factor NusA FOC96_RS13605 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC96_RS13610 ENOG4105VHM ribosomal protein FOC96_RS13620 ENOG4105W7A Protein of unknown function (DUF503) FOC96_RS13635 ENOG4105DTN riboflavin biosynthesis protein ribF FOC96_RS13655 ENOG4105C1V Peptidase, M16 FOC96_RS13665 ENOG4105E35 Dipicolinate synthase subunit A FOC96_RS13670 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC96_RS13675 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC96_RS13685 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC96_RS13695 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC96_RS13705 ENOG4107QZI cell division protein FtsK FOC96_RS13710 ENOG4105FDP GntR family transcriptional regulator FOC96_RS13715 ENOG4105DIH basic membrane FOC96_RS13720 ENOG4108JQ9 ABC transporter FOC96_RS13725 ENOG4105UIB (ABC) transporter FOC96_RS13745 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC96_RS13750 ENOG4105XZV Protein of unknown function (DUF3243) FOC96_RS13765 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC96_RS13790 ENOG4105D48 metallophosphoesterase FOC96_RS13795 ENOG4105MCT stage V sporulation protein S FOC96_RS13800 ENOG4108IGT Dipeptidase FOC96_RS13805 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC96_RS13810 ENOG4105DQU oxidoreductase, subunit beta FOC96_RS13840 ENOG4107QHE Choloylglycine hydrolase FOC96_RS13850 ENOG410890F Dynamin family FOC96_RS13855 ENOG4105E0M Sulfatase FOC96_RS13865 ENOG4105F0V Cell wall hydrolase FOC96_RS13955 ENOG4105BZU Histidine kinase FOC96_RS13960 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC96_RS13990 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC96_RS13995 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC96_RS14005 ENOG4105CGK Exodeoxyribonuclease III FOC96_RS14025 ENOG4105E0A ABC, transporter FOC96_RS14030 ENOG4105NIV Esterase FOC96_RS14040 ENOG4105VPX protein, conserved in bacteria FOC96_RS14045 ENOG410681U heavy metal transport detoxification protein FOC96_RS14050 ENOG4105C59 p-type ATPase FOC96_RS14060 ENOG4105K70 DNA-binding protein FOC96_RS14065 ENOG4105TMB Formate nitrite transporter FOC96_RS14085 ENOG4105C85 amino acid FOC96_RS14095 ENOG4108SJC Membrane FOC96_RS14100 ENOG4107QW4 alcohol dehydrogenase FOC96_RS14105 ENOG4105E98 transcriptional regulator DeoR family FOC96_RS14110 ENOG4105DE4 1-phosphofructokinase FOC96_RS14115 ENOG4105DM4 PTS System FOC96_RS14120 ENOG41069ER domain protein FOC96_RS14150 ENOG4106F1P AAA ATPase, central domain protein FOC96_RS14155 ENOG4105EN6 Membrane FOC96_RS14160 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC96_RS14165 ENOG4105CXI aluminum resistance protein FOC96_RS14170 ENOG4105KV4 Transcriptional regulator FOC96_RS14175 ENOG4105C5F glutamine synthetase FOC96_RS14185 ENOG4105K7K Transcriptional regulator FOC96_RS14205 ENOG4108SVB resolvase FOC96_RS14215 ENOG4105CGH 5'-nucleotidase FOC96_RS14255 ENOG4105BZ1 (ABC) transporter FOC96_RS14260 ENOG4105BZ1 (ABC) transporter FOC96_RS14275 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC96_RS14300 ENOG41067MG lrgb family FOC96_RS14310 ENOG4107RSM transcriptional regulator FOC96_RS14320 ENOG4105CJ1 ABC, transporter FOC96_RS14340 ENOG4107QIV Cytochrome c biogenesis protein FOC96_RS14385 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC96_RS14410 ENOG4108903 Formimidoylglutamase FOC96_RS14415 ENOG4108VJ1 Transcriptional regulator (CarD family FOC96_RS14420 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC96_RS14425 ENOG4105CBC glutamate synthase FOC96_RS14430 ENOG4105CK7 Sodium proline symporter FOC96_RS14435 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC96_RS14440 ENOG4105FBA Phospholipase Carboxylesterase FOC96_RS14445 ENOG4105BZU Histidine kinase FOC96_RS14455 ENOG4107AYK membrAne FOC96_RS14505 ENOG4105CEY Amp-dependent synthetase and ligase FOC96_RS14510 ENOG4107ZYJ bioY protein FOC96_RS14515 ENOG4107F3J Amp-dependent synthetase and ligase FOC96_RS14535 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC96_RS14575 ENOG4108I0Z Aconitate hydratase FOC96_RS14595 ENOG4108KU9 integrase family FOC96_RS14600 ENOG4108FPN Integrase FOC96_RS14615 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC96_RS14620 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC96_RS14650 ENOG4105W8X HesB YadR YfhF-family protein FOC96_RS14660 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC96_RS14665 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FOC96_RS14670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS14675 ENOG4105C0H protease FOC96_RS14680 ENOG4105K4P CoA-binding domain protein FOC96_RS14685 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC96_RS14700 ENOG4105D9R oxidoreductase FOC96_RS14710 ENOG4105CIG ABC transporter FOC96_RS14730 ENOG4105EMN RNA polymerase sigma factor FOC96_RS14740 ENOG4108KGH TRANSCRIPTIONal FOC96_RS14745 ENOG4107QJT sodium dicarboxylate symporter FOC96_RS14805 ENOG4105E1K spore germination protein FOC96_RS14810 ENOG4108JB9 formate dehydrogenase FOC96_RS14820 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC96_RS14825 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC96_RS14835 ENOG4105TMB Formate nitrite transporter FOC96_RS14840 ENOG4105D06 uba thif-type nad fad binding protein FOC96_RS14845 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC96_RS14850 ENOG4108ZAF Molybdopterin FOC96_RS14860 ENOG4105D1F ATP-binding protein FOC96_RS14875 ENOG410696E Membrane FOC96_RS14880 ENOG4105FR1 rard protein FOC96_RS14890 ENOG4105EWU Squalene--hopene cyclase FOC96_RS14900 ENOG4105CHR reductase FOC96_RS14905 ENOG4105C26 Dehydrogenase FOC96_RS14915 ENOG4108IA2 Sodium pantothenate symporter FOC96_RS14930 ENOG4106IQC argininosuccinate lyase FOC96_RS14940 ENOG410904N short-chain dehydrogenase reductase FOC96_RS14980 ENOG4105VEQ Cold shock protein FOC96_RS14995 ENOG4108R1P FOC96_RS15005 ENOG41073R8 VanW family FOC96_RS15010 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC96_RS15020 ENOG4105KT7 mgtC SapB transporter FOC96_RS15030 ENOG4105E39 Enoyl-CoA hydratase FOC96_RS15035 ENOG4105K64 Glycosyl transferase, family 2 FOC96_RS15045 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC96_RS15070 ENOG4105CQB FAD linked oxidase domain protein FOC96_RS15075 ENOG4105C09 Bile acid FOC96_RS15085 ENOG4105RHY Pfam:UPF0157 FOC96_RS15110 ENOG4105CIS alcohol dehydrogenase FOC96_RS15115 ENOG41082BM Transcriptional regulator, arsr family FOC96_RS15140 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC96_RS15170 ENOG4108A04 Beta-lactamase FOC96_RS15175 ENOG4105DPN Oligoendopeptidase f FOC96_RS15180 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC96_RS15185 ENOG4105E5K Alpha-amylase FOC96_RS15200 ENOG4105C98 muts2 protein FOC96_RS15220 ENOG4107V2S Transcriptional regulator FOC96_RS15240 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC96_RS15245 ENOG4105NX3 Membrane FOC96_RS15250 ENOG4105DQ5 transport system permease protein FOC96_RS15255 ENOG4105EHG Permease protein FOC96_RS15260 ENOG4108MES Periplasmic binding protein FOC96_RS15275 ENOG4107R3E Citrate transporter FOC96_RS15285 ENOG4108TN2 lmbE family FOC96_RS15355 ENOG4105H3G oxidoreductase FOC96_RS15390 ENOG4107YXZ hydrolase, family 25 FOC96_RS15405 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC96_RS15455 ENOG4105KAF membrAne FOC96_RS15520 ENOG4105KVH Transcriptional regulator FOC96_RS15525 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC96_RS15535 ENOG4105KNA -acetyltransferase FOC96_RS15545 ENOG4105CHR reductase FOC96_RS15555 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC96_RS15590 ENOG4105D9R oxidoreductase FOC96_RS15595 ENOG4108TZY GntR Family Transcriptional Regulator FOC96_RS15630 ENOG4105C44 Serine transporter FOC96_RS15650 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC96_RS15665 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC96_RS15670 ENOG4105C6Z Gluconate FOC96_RS15675 ENOG4105CMG Carbohydrate kinase FOC96_RS15680 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC96_RS15685 ENOG4105XDF Protein of unknown function (DUF1272) FOC96_RS15690 ENOG4105DDN Pentapeptide repeat-containing protein FOC96_RS15705 ENOG4105C37 (CBS) domain FOC96_RS15735 ENOG4105EV4 Multidrug resistance protein mdtH FOC96_RS15745 ENOG4105DMQ Methyltransferase FOC96_RS15785 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC96_RS15795 ENOG4108UW5 maltose o-acetyltransferase FOC96_RS15800 ENOG4106UW1 Major Facilitator superfamily FOC96_RS15805 ENOG4105DKQ ROK family FOC96_RS15810 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC96_RS15845 ENOG4105D7V transposase FOC96_RS15880 ENOG4105CJ1 ABC, transporter FOC96_RS15890 ENOG4108PSK reductase FOC96_RS15910 ENOG4108RCM Nitroreductase FOC96_RS15915 ENOG4105KVH Transcriptional regulator FOC96_RS15935 ENOG4105WH1 Two component transcriptional regulator luxr family FOC96_RS15945 ENOG4108Z66 YbaK ebsC protein FOC96_RS15965 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC96_RS15970 ENOG4105DSE periplasmic solute binding protein FOC96_RS15990 ENOG4107TXC Transcriptional regulator FOC96_RS16035 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC96_RS16070 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC96_RS16080 ENOG4105CRW Short chain fatty acid transporter FOC96_RS16090 ENOG4107AUC FOC96_RS16095 ENOG4105KBX Transcriptional regulator, TetR family FOC96_RS16100 ENOG4105KPY Small multidrug resistance protein FOC96_RS16105 ENOG4105RXJ FOC96_RS16115 ENOG41069JR FOC96_RS16120 ENOG4105DA5 (ABC) transporter FOC96_RS16135 ENOG4105CZM Major Facilitator FOC96_RS16140 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC96_RS16150 ENOG4108ISG Major Facilitator FOC96_RS16190 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC96_RS16205 ENOG4108IBT Inherit from COG: transposase FOC96_RS16220 ENOG410874W AraC family transcriptional regulator FOC96_RS16225 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC96_RS16245 ENOG4108JQ1 Dehydrogenase FOC96_RS16260 ENOG4105DVH amino acid FOC96_RS16270 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC96_RS16285 ENOG4108JPW Aminotransferase FOC96_RS16290 ENOG4105MZU cell filamentation protein FOC96_RS16300 ENOG4105EJQ L-serine dehydratase FOC96_RS16305 ENOG4105C44 Serine transporter FOC96_RS16330 ENOG4108FPN Integrase FOC96_RS16335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC96_RS16360 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC96_RS16400 ENOG4105TRI Hydrolase FOC96_RS16450 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC96_RS16455 ENOG4105D4Y metalloprotease FOC96_RS16460 ENOG4105CEP NADH dehydrogenase FOC96_RS16475 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC96_RS16490 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC96_RS16500 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FOC96_RS16505 ENOG4108U05 Transcriptional regulator FOC96_RS16520 ENOG4105BZU Histidine kinase FOC96_RS16535 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC96_RS16555 ENOG4105JQZ Methyltransferase FOC96_RS16560 ENOG4105W1Y Transcriptional regulator FOC96_RS16570 ENOG4105C88 aminopeptidase FOC96_RS16585 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC96_RS16595 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC96_RS16600 ENOG4108NNI Beta-lactamase domain-containing protein FOC96_RS16625 ENOG4105K6H D-cysteine desulfhydrase FOC96_RS16650 ENOG41062D9 Histidine kinase FOC96_RS16655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS16670 ENOG4105IIP Membrane FOC96_RS16680 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC96_RS16685 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC96_RS16720 ENOG4105F7F Chaperone FOC96_RS16735 ENOG41085FC arsR family transcriptional regulator FOC96_RS16740 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC96_RS16745 ENOG4105D6J arsenicaL-resistance protein FOC96_RS16770 ENOG4105DIK (ABC) transporter FOC96_RS16775 ENOG4105CC5 ABC transporter FOC96_RS16780 ENOG4105DSE periplasmic solute binding protein FOC96_RS16785 ENOG4108NEV two component transcriptional regulator, LytTR family FOC96_RS16800 ENOG4105C19 ABC transporter FOC96_RS16810 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC96_RS16815 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC96_RS16825 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC96_RS16840 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC96_RS16845 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC96_RS16860 ENOG4105F2M alpha beta hydrolase fold-3 domain protein FOC96_RS16910 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC96_RS16915 ENOG4108606 TspO/MBR family FOC96_RS16965 ENOG41061CK Antibiotic biosynthesis monooxygenase FOC96_RS16970 ENOG4105CGH 5'-nucleotidase FOC96_RS17010 ENOG4105CSV Glutaminase FOC96_RS17030 ENOG4105II7 pyrroline-5-carboxylate reductase FOC96_RS17035 ENOG4105CUB amino acid FOC96_RS17040 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC96_RS17060 ENOG41075H3 AraC family transcriptional regulator FOC96_RS17100 ENOG4108B31 Spore germination protein FOC96_RS17125 ENOG4108IMY Transcriptional regulator FOC96_RS17130 ENOG4105HDK L-asparaginase FOC96_RS17135 ENOG4108IJ0 Aspartate ammonia-lyase FOC96_RS17145 ENOG4105E2A Dehydrogenase FOC96_RS17210 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC96_RS17240 ENOG4105DWD nucleoside recognition domain protein FOC96_RS17255 ENOG4105FDT acyl-CoA dehydrogenase FOC96_RS17265 ENOG4108ZHR arsR family transcriptional regulator FOC96_RS17270 ENOG4108ZRV stage ii sporulation protein p FOC96_RS17275 ENOG4106N3A copper homeostasis protein cutc FOC96_RS17285 ENOG4107258 Transcriptional regulator FOC96_RS17290 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC96_RS17320 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC96_RS17325 ENOG4107RF6 penicillin-binding protein FOC96_RS17355 ENOG4105F1N DNA alkylation repair FOC96_RS17365 ENOG4108IQI permease FOC96_RS17370 ENOG4105KNA -acetyltransferase FOC96_RS17375 ENOG410635A Membrane FOC96_RS17435 ENOG4108XET gCN5-related N-acetyltransferase FOC96_RS17465 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC96_RS17485 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC96_RS17520 ENOG4105FS7 Transcriptional regulator FOC96_RS17525 ENOG4108TVJ Nitroreductase FOC96_RS17565 ENOG4105CH6 catalase FOC96_RS17570 ENOG4105C8Y Acetylornithine aminotransferase FOC96_RS17580 ENOG4105CKK Glycosyl transferase, family 2 FOC96_RS17595 ENOG4105CKK Glycosyl transferase, family 2 FOC96_RS17605 ENOG4105CSH Transporter FOC96_RS17620 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC96_RS17645 ENOG41068WN FOC96_RS17655 ENOG4108WCX response regulator FOC96_RS17665 ENOG41090T1 Membrane FOC96_RS17680 ENOG4105VMP Transcriptional regulator FOC96_RS17690 ENOG4105G6Z alkaline phosphatase FOC96_RS17695 ENOG4105ECK Fatty Acid Desaturase FOC96_RS17700 ENOG4105E0Y RtcB Protein FOC96_RS17710 ENOG4107258 Transcriptional regulator FOC96_RS17720 ENOG4105II7 pyrroline-5-carboxylate reductase FOC96_RS17755 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC96_RS17780 ENOG41061GT Aldolase FOC96_RS17790 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC96_RS17795 ENOG4105DKT Transcriptional regulator FOC96_RS17805 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC96_RS17810 ENOG4105F5R ABC transporter FOC96_RS17815 ENOG4105D4B ABC, transporter FOC96_RS17830 ENOG4108JUB Transcriptional regulator FOC96_RS17835 ENOG4105J5T Amp-dependent synthetase and ligase FOC96_RS17840 ENOG4105E39 Enoyl-CoA hydratase FOC96_RS17845 ENOG4105CY2 Citrate transporter FOC96_RS17855 ENOG41069ER domain protein FOC96_RS17875 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC96_RS17895 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC96_RS17905 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC96_RS17925 ENOG41082JN Transcriptional regulator FOC96_RS17930 ENOG4105EYF MMPL domain protein FOC96_RS17940 ENOG4105C5H ABC transporter FOC96_RS17945 ENOG4105E0M Sulfatase FOC96_RS17950 ENOG4108ZCF integral membrane protein FOC96_RS18020 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC96_RS18040 ENOG4105E09 nadh pyrophosphatase FOC96_RS18055 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC96_RS18060 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC96_RS18065 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC96_RS18075 ENOG4105C02 permease FOC96_RS18125 ENOG4105DVE abc transporter atp-binding protein FOC96_RS18140 ENOG4108ZMI UPF0477 protein FOC96_RS18155 ENOG4105CHM Aminotransferase FOC96_RS18185 ENOG41089UC methyltransferase, type 11 FOC96_RS18200 ENOG4107BMA Transglycosylase associated protein FOC96_RS18220 ENOG4106K7D Major facilitator family transporter FOC96_RS18225 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC96_RS18280 ENOG4105EPR degv family FOC96_RS18290 ENOG4105DVH amino acid FOC96_RS18295 ENOG4105DPN Oligoendopeptidase f FOC96_RS18325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS18330 ENOG4105BZU Histidine kinase FOC96_RS18335 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC96_RS18380 ENOG4105DTQ mandelate racemase muconate lactonizing FOC96_RS18395 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC96_RS18400 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC96_RS18415 ENOG4107T5V SNARE associated Golgi FOC96_RS18445 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC96_RS18455 ENOG41080HI glycine oxidase FOC96_RS18460 ENOG4105CTU Proline racemase FOC96_RS18465 ENOG4105CTU Proline racemase FOC96_RS18470 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC96_RS18475 ENOG4105C26 Dehydrogenase FOC96_RS18480 ENOG4105BZG amino acid carrier protein FOC96_RS18500 ENOG4108M1A Chitin-binding protein FOC96_RS18550 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC96_RS18570 ENOG4105EEM helicase FOC96_RS18590 ENOG4108Z7F N-acetyltransferase FOC96_RS18620 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC96_RS18625 ENOG4107YB6 acetyltransferase, (GNAT) family FOC96_RS18630 ENOG4105MSB protein, conserved in bacteria FOC96_RS18635 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC96_RS18650 ENOG4108M1A Chitin-binding protein FOC96_RS18655 ENOG41082BV acetyltransferase FOC96_RS18660 ENOG4105E66 phosphoriboisomerase A FOC96_RS18685 ENOG4108IJ7 Glycine betaine FOC96_RS18690 ENOG4107SQ8 Glycine betaine FOC96_RS18715 ENOG4105M6F mutator MutT protein FOC96_RS18725 ENOG4105DBI uridine monophosphokinase FOC96_RS18730 ENOG4105RHY Pfam:UPF0157 FOC96_RS18735 ENOG4105E1F short-chain dehydrogenase reductase FOC96_RS18745 ENOG4107RUY (E1 component), alpha subunit FOC96_RS18755 ENOG4107QKR Dehydrogenase FOC96_RS18775 ENOG41062ES Transcriptional regulator FOC96_RS18795 ENOG4105E98 transcriptional regulator DeoR family FOC96_RS18800 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC96_RS18815 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC96_RS18850 ENOG4107Z3H Transcriptional regulator, TetR family FOC96_RS18885 ENOG4105MSI germination protein ypeb FOC96_RS18940 ENOG4105FDR Membrane FOC96_RS18950 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC96_RS18955 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC96_RS18980 ENOG4108IUM Glycogen debranching enzyme FOC96_RS19025 ENOG4107VFR oxidoreductase FOC96_RS19060 ENOG4105PKS Excinuclease abc c subunit domain protein FOC96_RS19095 ENOG4105KWG Pfam:DUF1696 FOC96_RS19100 ENOG4108NRW Phospholipase, patatin family FOC96_RS19120 ENOG4108XI2 Domain of unknown function (DUF1963) FOC96_RS19130 ENOG4107TB6 phosphoglycerate mutase FOC96_RS19155 ENOG4108Z4K mutator MutT protein FOC96_RS19160 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC96_RS19165 ENOG4105E09 nadh pyrophosphatase FOC96_RS19170 ENOG4105FCD Major Facilitator FOC96_RS19205 ENOG4107Y9U Membrane FOC96_RS19230 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC96_RS19245 ENOG4107Y80 Major Facilitator superfamily FOC96_RS19260 ENOG4108V4B ThiJ pfpI FOC96_RS19300 ENOG4105FQP Beta-lactamase FOC96_RS19310 ENOG4105CHR reductase FOC96_RS19315 ENOG4108IG5 Transcriptional regulator FOC96_RS19320 ENOG4105CJN penicillin-binding protein FOC96_RS19325 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC96_RS19330 ENOG4105CB2 alcohol dehydrogenase FOC96_RS19335 ENOG4105RHY Pfam:UPF0157 FOC96_RS19345 ENOG4108HGU Histidine kinase FOC96_RS19380 ENOG4107RF6 penicillin-binding protein FOC96_RS19385 ENOG4105BZU Histidine kinase FOC96_RS19390 ENOG410667J hydrolase FOC96_RS19500 ENOG4105ETU transcriptional activator (TenA FOC96_RS19585 ENOG4105DK7 lysyl-tRNA synthetase FOC96_RS19595 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC96_RS19660 ENOG4105CUV Homoserine Kinase FOC96_RS19675 ENOG41089UC methyltransferase, type 11 FOC96_RS19710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC96_RS19710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC96_RS19750 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC96_RS19790 ENOG4105DBI uridine monophosphokinase FOC96_RS19805 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC96_RS19810 ENOG4107QX3 carboxylase FOC96_RS19815 ENOG4105E39 Enoyl-CoA hydratase FOC96_RS19820 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC96_RS19825 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC96_RS19830 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC96_RS19835 ENOG4105C1G acyl-Coa dehydrogenase FOC96_RS19865 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC96_RS19895 ENOG4105BZU Histidine kinase FOC96_RS19900 ENOG4105C5H ABC transporter FOC96_RS19905 ENOG41067SE Tetr family transcriptional regulator FOC96_RS19910 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FOC96_RS19925 ENOG4108VXD carboxy-peptidase FOC96_RS19940 ENOG4105VZ8 Transcriptional regulator FOC96_RS19945 ENOG4107JM4 Tetratricopeptide repeat FOC96_RS19955 ENOG4105CGH 5'-nucleotidase FOC96_RS19980 ENOG4105DH8 myo-inositol catabolism FOC96_RS19985 ENOG4105D2N Aldolase FOC96_RS20010 ENOG4105CK5 oxidoreductase FOC96_RS20015 ENOG4105IE8 Alpha-ketoglutarate permease FOC96_RS20020 ENOG4105ETE Transcriptional regulator (LacI family FOC96_RS20035 ENOG4107RF6 penicillin-binding protein FOC96_RS20040 ENOG4107RF6 penicillin-binding protein FOC96_RS20055 ENOG4107RVG penicillin-binding protein FOC96_RS20070 ENOG4105EQK -acetyltransferase FOC96_RS20080 ENOG4105CIN aminoacyl-histidine dipeptidase FOC96_RS20115 ENOG41090HR transcriptional regulator FOC96_RS20210 ENOG41088CC tellurite resistance protein tehB FOC96_RS20230 ENOG4108RZE Tetr family transcriptional regulator FOC96_RS20245 ENOG4105C1J atp-dependent rna helicase FOC96_RS20260 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC96_RS20295 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC96_RS20305 ENOG4105RD7 BadF BadG BcrA BcrD FOC96_RS20330 ENOG4105F32 YngK protein FOC96_RS20355 ENOG4108KPJ rna polymerase sigma factor FOC96_RS20360 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FOC96_RS20370 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC96_RS20400 ENOG4108JCI Transcriptional regulator FOC96_RS20405 ENOG4105N14 lysine exporter protein LysE YggA FOC96_RS20420 ENOG4105BZ1 (ABC) transporter FOC96_RS20425 ENOG4105BZ1 (ABC) transporter FOC96_RS20440 ENOG4108RPX mosc domain containing protein FOC96_RS20445 ENOG4105DND Transcriptional regulator FOC96_RS20460 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC96_RS20465 ENOG4107V2S Transcriptional regulator FOC96_RS20490 ENOG4105VEQ Cold shock protein FOC96_RS20500 ENOG41068WN FOC96_RS20505 ENOG41089UC methyltransferase, type 11 FOC96_RS20515 ENOG4105C1Q protoporphyrinogen oxidase FOC96_RS20545 ENOG4105WCN acetyltransferase FOC96_RS20570 ENOG4105EYF MMPL domain protein FOC96_RS20580 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC96_RS20595 ENOG41081I9 integral membrane protein FOC96_RS20625 ENOG4108D32 Methyltransferase FOC96_RS20650 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC96_RS20665 ENOG4105C19 ABC transporter FOC96_RS20675 ENOG4105C22 threonyL-tRNA synthetase FOC96_RS20680 ENOG4105FE9 pseudouridine synthase FOC96_RS20700 ENOG4105BZG amino acid carrier protein FOC96_RS20720 ENOG4105K70 DNA-binding protein FOC96_RS20735 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC96_RS20740 ENOG4105WQT MbtH domain protein FOC96_RS20745 ENOG4105CEY Amp-dependent synthetase and ligase FOC96_RS20750 ENOG4105WQI isochorismatase FOC96_RS20755 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC96_RS20760 ENOG4105E4F Isochorismate synthase FOC96_RS20765 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC96_RS20770 ENOG4105FCD Major Facilitator FOC96_RS20795 ENOG4107RFY SbcCD D subunit FOC96_RS20810 ENOG4105E39 Enoyl-CoA hydratase FOC96_RS20815 ENOG4105N14 lysine exporter protein LysE YggA FOC96_RS20825 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC96_RS20830 ENOG4105C1G acyl-Coa dehydrogenase FOC96_RS20835 ENOG4105CR4 methylisocitrate lyase FOC96_RS20840 ENOG4105DXD 2-methylcitrate dehydratase FOC96_RS20850 ENOG4105W8X HesB YadR YfhF-family protein FOC96_RS20855 ENOG4105CZM Major Facilitator FOC96_RS20865 ENOG4105BZ4 penicillin-binding protein FOC96_RS20915 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC96_RS20975 ENOG4105SZ6 Thioredoxin FOC96_RS20985 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC96_RS20990 ENOG4108N23 SpoOM-related protein FOC96_RS21030 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC96_RS21035 ENOG4108JUB Transcriptional regulator FOC96_RS21040 ENOG4108TSC N-acetyltransferase FOC96_RS21045 ENOG4107S4Y M20 DapE family protein YgeY FOC96_RS21060 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC96_RS21085 ENOG4105C37 (CBS) domain FOC96_RS21120 ENOG4105E90 ABC transporter FOC96_RS21125 ENOG4108IJ8 ABC transporter FOC96_RS21155 ENOG4105CMG Carbohydrate kinase FOC96_RS21190 ENOG4105WH1 Two component transcriptional regulator luxr family FOC96_RS21195 ENOG4105BZU Histidine kinase FOC96_RS21200 ENOG4105D8X mechanosensitive ion channel FOC96_RS21235 ENOG4105F0I Aminotransferase FOC96_RS21240 ENOG4108MES Periplasmic binding protein FOC96_RS21260 ENOG4105CAQ asparagine synthetase FOC96_RS21265 ENOG4107Y70 Heat shock protein FOC96_RS21270 ENOG4108KF3 Electron transport protein SCO1 SenC FOC96_RS21275 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC96_RS21280 ENOG4108RCR degv family FOC96_RS21290 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC96_RS21300 ENOG4108UT2 hemolysin iii FOC96_RS21305 ENOG4105E9Q Acyl-transferase FOC96_RS21315 ENOG4107RVG penicillin-binding protein FOC96_RS21335 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC96_RS21355 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC96_RS21380 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC96_RS21385 ENOG4105KD7 acetyltransferase FOC96_RS21400 ENOG4105C0A alcohol dehydrogenase FOC96_RS21405 ENOG4105CY2 Citrate transporter FOC96_RS21410 ENOG4107XGZ Hydrolase FOC96_RS21430 ENOG4105C8J )-transporter FOC96_RS21445 ENOG41062D9 Histidine kinase FOC96_RS21450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS21455 ENOG4107QPK )-transporter FOC96_RS21460 ENOG4105BZW Glycerate kinase FOC96_RS21580 ENOG4105EC2 ftsk spoIIIe FOC96_RS21600 ENOG4105C5S asparaginyl-tRNA synthetase FOC96_RS21640 ENOG4105C75 arginyL-tRNA synthetase FOC96_RS21645 ENOG4107YX5 Pfam:DUF548 FOC96_RS21675 ENOG4108UUM single-stranded DNA-binding protein FOC96_RS21690 ENOG4105C5H ABC transporter FOC96_RS21755 ENOG4105MCT stage V sporulation protein S FOC96_RS21790 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC96_RS21795 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC96_RS21800 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC96_RS21805 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC96_RS21810 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC96_RS21815 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC96_RS21835 ENOG4108ZAF Molybdopterin FOC96_RS21840 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC96_RS21845 ENOG4105D06 uba thif-type nad fad binding protein FOC96_RS21850 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC96_RS21855 ENOG4107V6Q Cyclic nucleotide-binding domain FOC96_RS21865 ENOG4105R3A Nitrate reductase FOC96_RS21870 ENOG4108IUE nitrate reductase beta subunit FOC96_RS21890 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC96_RS21905 ENOG4108V06 Glutathione peroxidase FOC96_RS21915 ENOG4105CNW domain protein FOC96_RS21930 ENOG4105EMN RNA polymerase sigma factor FOC96_RS21935 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC96_RS21945 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC96_RS21970 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC96_RS21995 ENOG4105KBJ sporulation protein ytfj FOC96_RS22075 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC96_RS22105 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC96_RS22110 ENOG4108JYZ YitT family FOC96_RS22115 ENOG41087PP glycosyltransferase MGT family FOC96_RS22135 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC96_RS22145 ENOG4108X4Q Hydrolase FOC96_RS22155 ENOG41069HH 4-oxalocrotonate tautomerase FOC96_RS22175 ENOG4105IKQ hydratase FOC96_RS22185 ENOG4105KME endoribonuclease L-psp FOC96_RS22200 ENOG4105U1N riboflavin FOC96_RS22210 ENOG4105EFA 4-hydroxyphenylacetate FOC96_RS22230 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC96_RS22240 ENOG4108VXD carboxy-peptidase FOC96_RS22250 ENOG4108ZRV stage ii sporulation protein p FOC96_RS22270 ENOG4108Z7R Chaperone CsaA FOC96_RS22290 ENOG4105C37 (CBS) domain FOC96_RS22295 ENOG4105SXS Protein of unknown function (DUF456) FOC96_RS22315 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC96_RS22325 ENOG4108S4H thioesterase Superfamily protein FOC96_RS22335 ENOG4108PJD permease FOC96_RS22350 ENOG4107T5V SNARE associated Golgi FOC96_RS22370 ENOG4105CVJ phosphoglycerate mutase FOC96_RS22395 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC96_RS22405 ENOG4105K4T epimerase FOC96_RS22415 ENOG4105DSE periplasmic solute binding protein FOC96_RS22420 ENOG4108IBT Inherit from COG: transposase FOC96_RS22440 ENOG4105CKI cobalamin synthesis protein FOC96_RS22445 ENOG4107QM2 Aldo Keto reductase FOC96_RS22465 ENOG4105DEN Luciferase family FOC96_RS22480 ENOG4108WPJ Ferritin-like domain FOC96_RS22485 ENOG4108K88 Membrane FOC96_RS22500 ENOG4105C8Q Methyl-accepting chemotaxis FOC96_RS22525 ENOG4107XZQ multidrug resistance protein FOC96_RS22530 ENOG4107SET aldo keto reductase FOC96_RS22535 ENOG4105YVS arsR family transcriptional regulator FOC96_RS22545 ENOG4105KRN Transcriptional regulator, abrb family FOC96_RS22595 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC96_RS22600 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC96_RS22610 ENOG4105YWU small acid-soluble spore protein FOC96_RS22615 ENOG4108WBH protein TIM barrel FOC96_RS22630 ENOG4105CEY Amp-dependent synthetase and ligase FOC96_RS22635 ENOG4105DUU IucA IucC family protein FOC96_RS22645 ENOG4105VRR gCN5-related N-acetyltransferase FOC96_RS22650 ENOG4105KT7 mgtC SapB transporter FOC96_RS22665 ENOG4105BZU Histidine kinase FOC96_RS22670 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC96_RS22680 ENOG4108KGH TRANSCRIPTIONal FOC96_RS22705 ENOG4105D6E homoserine dehydrogenase FOC96_RS22730 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC96_RS22750 ENOG4105EB3 Histidine kinase FOC96_RS22755 ENOG4105EFI regulatoR FOC96_RS22760 ENOG4105BZ1 (ABC) transporter FOC96_RS22790 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC96_RS22805 ENOG4108JJ8 (ABC) transporter FOC96_RS22810 ENOG4108JJ9 ABC, transporter FOC96_RS22815 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC96_RS22820 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC96_RS22850 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family FOC96_RS22860 ENOG4105C32 Amino acid ABC transporter (Permease) FOC96_RS22865 ENOG4108IV0 ABC, transporter FOC96_RS22870 ENOG4105C0Z ABC transporter FOC96_RS22880 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC96_RS22885 ENOG4108Z7G MaoC domain protein dehydratase FOC96_RS22905 ENOG4105CKI cobalamin synthesis protein FOC96_RS22920 ENOG4106F5Q Membrane FOC96_RS22925 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC96_RS22930 ENOG4108TVJ Nitroreductase FOC96_RS22935 ENOG4107ZXU DSBA oxidoreductase FOC96_RS22940 ENOG4108Z40 Transcriptional regulator FOC96_RS22945 ENOG4105GZI Transcriptional regulator FOC96_RS22950 ENOG4107RT3 EamA-like transporter family FOC96_RS22960 ENOG4105KTB nuclear export factor GLE1 FOC96_RS22965 ENOG4108T5E Copper resistance protein FOC96_RS23010 ENOG4107R16 Multicopper oxidase FOC96_RS23015 ENOG4107RAQ aminopeptidase FOC96_RS23045 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC96_RS23050 ENOG4105D9N nucleoside FOC96_RS23060 ENOG4107RHR regulatoR FOC96_RS23070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC96_RS23115 ENOG4105C0X amino acid FOC96_RS23120 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC96_RS23135 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC96_RS23155 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC96_RS23160 ENOG41068WN FOC96_RS23205 ENOG4108IBT Inherit from COG: transposase FOC96_RS23225 ENOG4105CYC Transferase FOC96_RS23230 ENOG4105DY9 regulatoR FOC96_RS23250 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC96_RS23255 ENOG4105C6X Major Facilitator FOC96_RS23280 ENOG4105C7B Threonine dehydratase FOC96_RS23290 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC96_RS23300 ENOG4105C7K acetolactate synthase FOC96_RS23305 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC96_RS23310 ENOG4105CHR reductase FOC96_RS23315 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC96_RS23330 ENOG4106KE4 Dehydrogenase FOC96_RS23345 ENOG4105H67 Protein of unknown function (DUF421) FOC96_RS23350 ENOG4105X5K response regulator receiver protein FOC96_RS23360 ENOG4105C8J )-transporter FOC96_RS23380 ENOG4105C6T cysteine synthase FOC96_RS23385 ENOG4105EU0 Major facilitator Superfamily FOC96_RS23395 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC96_RS23410 ENOG4105DXI Major Facilitator superfamily FOC96_RS23415 ENOG4105CSR polyphosphate kinase 2 FOC96_RS23450 ENOG4105FVX FOC96_RS23470 ENOG41067QW Transcriptional regulator FOC96_RS23505 ENOG4105C6K Malic enzyme FOC96_RS23510 ENOG4108IJ0 Aspartate ammonia-lyase FOC96_RS23520 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC96_RS23540 ENOG4105CJ1 ABC, transporter FOC96_RS23575 ENOG4106BRA Membrane FOC96_RS23610 ENOG4107QIV Cytochrome c biogenesis protein FOC96_RS23630 ENOG4105EC3 peptidase S51, dipeptidase E FOC96_RS23635 ENOG4107QJQ Mate efflux family protein FOC96_RS23655 ENOG4105C9Q fumarate hydratase class II FOC96_RS23660 ENOG4105DFD Na H antiporter FOC96_RS23675 ENOG4108PJD permease FOC96_RS23680 ENOG4105CKI cobalamin synthesis protein FOC96_RS23685 ENOG4108UZ3 Transporter FOC96_RS23690 ENOG4105DRR Transcriptional regulator, GntR family FOC96_RS23700 ENOG4105PGM cation diffusion facilitator family transporter FOC96_RS23720 ENOG4105CAQ asparagine synthetase FOC96_RS23730 ENOG4105K56 Transcriptional regulator FOC96_RS23750 ENOG4105CVJ phosphoglycerate mutase FOC96_RS23790 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC96_RS23795 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC96_RS23800 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC96_RS23805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC96_RS23835 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC96_RS23870 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC96_RS23875 ENOG4105KTQ flagellar basal-body rod protein FOC96_RS23880 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC96_RS23885 ENOG4105D7B Flagellar biosynthesis protein flha FOC96_RS23890 ENOG4105D00 flagellar biosynthetic protein flhB FOC96_RS23900 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC96_RS23905 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC96_RS23915 ENOG4105DD5 Flagellar motor switch protein FOC96_RS23920 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC96_RS23930 ENOG4105E4C Lytic transglycosylase catalytic FOC96_RS23940 ENOG4105I03 Flagellin FOC96_RS23950 ENOG4107R88 Chemotaxis protein (CheV) FOC96_RS23965 ENOG4105BZE flagellar hook protein, FlgE FOC96_RS23995 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC96_RS24000 ENOG4107U2N Flagellar M-ring protein FOC96_RS24010 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC96_RS24015 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC96_RS24030 ENOG4107TPX flagellar hook-associated FOC96_RS24035 ENOG4105DTJ flagellar hook-associated protein FOC96_RS24040 ENOG4105E1Q flagellar hook-associated protein FOC96_RS24060 ENOG4105BZU Histidine kinase FOC96_RS24075 ENOG4105DD5 Flagellar motor switch protein FOC96_RS24080 ENOG4105CBS Chea signal transduction histidine kinase FOC96_RS24085 ENOG4107YTP response regulator receiver protein FOC96_RS24090 ENOG4105ER2 Ompa motb domain protein FOC96_RS24095 ENOG4107R0U MotA TolQ exbB proton channel FOC96_RS24105 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC96_RS24160 ENOG41080C8 DUF218 domain FOC96_RS24165 ENOG4105H67 Protein of unknown function (DUF421) FOC96_RS24175 ENOG4108Z5V transcriptional regulator, merr family FOC96_RS24180 ENOG4105CN5 Metallo-Beta-Lactamase FOC96_RS24185 ENOG4107RWR Sodium hydrogen exchanger FOC96_RS24190 ENOG4108FPN Integrase FOC96_RS24195 ENOG4108KU9 integrase family FOC96_RS24215 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC96_RS24280 ENOG41081VK Ribonuclease FOC96_RS24300 ENOG4108SZE gCN5-related N-acetyltransferase FOC96_RS24330 ENOG4106032 Glutathionylspermidine synthase FOC96_RS24360 ENOG4105KHC sulfurtransferase FOC96_RS24370 ENOG4108W0I acetyltransferase FOC96_RS24380 ENOG410890F Dynamin family FOC96_RS24385 ENOG4105DHF Membrane FOC96_RS24390 ENOG4105C2W permease FOC96_RS24400 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC96_RS24415 ENOG4105CTD carboxy-peptidase FOC96_RS24420 ENOG4105DVT helicase FOC96_RS24430 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC96_RS24490 ENOG4105BZ4 penicillin-binding protein FOC96_RS24500 ENOG4105CSM endonuclease III FOC96_RS24520 ENOG4105YAC FOC96_RS24525 ENOG4105DVT helicase FOC96_RS24560 ENOG4105CPK Glycosyl transferase (Group 1 FOC96_RS24565 ENOG4105FJR Lmbe family FOC96_RS24580 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC96_RS24585 ENOG4108JYZ YitT family FOC96_RS24615 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC96_RS24620 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC96_RS24625 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC96_RS24640 ENOG41068YB TPR repeat-containing protein FOC96_RS24645 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC96_RS24665 ENOG4105EAH synthase FOC96_RS24675 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC96_RS24690 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC96_RS24720 ENOG41065D1 FOC96_RS24725 ENOG4105S2F FOC96_RS24760 ENOG4105HDK L-asparaginase FOC96_RS24765 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC96_RS24790 ENOG4108S6Z Negative regulator of genetic competence FOC96_RS24795 ENOG4107X2D transcriptional regulator, merr family FOC96_RS24800 ENOG4107RGJ metallophosphoesterase FOC96_RS24810 ENOG4105I7S Abortive infection protein FOC96_RS24815 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC96_RS24830 ENOG4108SAX Membrane FOC96_RS24840 ENOG41063SB peptidase FOC96_RS24845 ENOG4108WBT adenosyltransferase FOC96_RS24850 ENOG4105BZU Histidine kinase FOC96_RS24855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS24860 ENOG4105CRE cytochrome C FOC96_RS24865 ENOG4107TWT Cytochrome c biogenesis protein FOC96_RS24875 ENOG4105FE9 pseudouridine synthase FOC96_RS24885 ENOG4108JIC nucleoside recognition domain protein FOC96_RS24890 ENOG4105DZ1 carboxypeptidase FOC96_RS24895 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC96_RS24925 ENOG4105BZU Histidine kinase FOC96_RS24940 ENOG4105I3N Conserved Protein FOC96_RS24945 ENOG4105BZU Histidine kinase FOC96_RS24960 ENOG4105BZ4 penicillin-binding protein FOC96_RS24965 ENOG4107GRR phosphate transport regulator FOC96_RS24970 ENOG4105CJ3 phosphate transporter FOC96_RS25015 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC96_RS25035 ENOG4105WH1 Two component transcriptional regulator luxr family FOC96_RS25040 ENOG4105ENE Histidine kinase FOC96_RS25060 ENOG4105DFD Na H antiporter FOC96_RS25080 ENOG4105C8J )-transporter FOC96_RS25085 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC96_RS25090 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC96_RS25095 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC96_RS25105 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC96_RS25110 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC96_RS25130 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC96_RS25140 ENOG4105E0M Sulfatase FOC96_RS25145 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC96_RS25150 ENOG4105C5I Dehydrogenase FOC96_RS25160 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC96_RS25235 ENOG4108ZP8 Acetolactate synthase small subunit FOC96_RS25240 ENOG4105C7K acetolactate synthase FOC96_RS25245 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC96_RS25270 ENOG4105KBJ sporulation protein ytfj FOC96_RS25275 ENOG41063Y9 FOC96_RS25280 ENOG4105CZN Potassium uptake protein FOC96_RS25310 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC96_RS25315 ENOG4107QMU Mate efflux family protein FOC96_RS25350 ENOG4105NQC Flavodoxin FOC96_RS25375 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC96_RS25385 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC96_RS25390 ENOG4105EA8 2-Nitropropane dioxygenase FOC96_RS25395 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC96_RS25435 ENOG4105CJ1 ABC, transporter FOC96_RS25445 ENOG4105CZV ABC transporter FOC96_RS25450 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC96_RS25455 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC96_RS25465 ENOG41079K6 HNH endonuclease FOC96_RS25470 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC96_RS25475 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC96_RS25515 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC96_RS25520 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC96_RS25530 ENOG4105BZU Histidine kinase FOC96_RS25535 ENOG4106DF1 FOC96_RS25545 ENOG41090MY MarR family Transcriptional regulator FOC96_RS25550 ENOG4105BZU Histidine kinase FOC96_RS25560 ENOG4105PXI polysaccharide deacetylase FOC96_RS25570 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC96_RS25580 ENOG4105E98 transcriptional regulator DeoR family FOC96_RS25600 ENOG4107RCV ABC transporter, permease FOC96_RS25605 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC96_RS25610 ENOG4105C4Y ABC transporter FOC96_RS25630 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC96_RS25640 ENOG4105CHR reductase FOC96_RS25660 ENOG4108Z7G MaoC domain protein dehydratase FOC96_RS25665 ENOG410681C small acid-soluble spore protein FOC96_RS25670 ENOG4105CZN Potassium uptake protein FOC96_RS25675 ENOG4107TS3 membrane protein, TerC FOC96_RS25680 ENOG4108QTI )-transporter FOC96_RS25690 ENOG4106A3R peptidase FOC96_RS25710 ENOG4105JXH GntR family transcriptional regulator FOC96_RS25715 ENOG4105BZU Histidine kinase FOC96_RS25720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS25735 ENOG4105CQB FAD linked oxidase domain protein FOC96_RS25740 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC96_RS25745 ENOG4105K4I Scp-like extracellular FOC96_RS25755 ENOG4108YBP pseudouridine synthase FOC96_RS25765 ENOG4105EYF MMPL domain protein FOC96_RS25775 ENOG4107RUE extracellular solute-binding protein family 1 FOC96_RS25780 ENOG4105D38 putrescine abc transporter FOC96_RS25785 ENOG4105F38 ABC transporter, permease FOC96_RS25795 ENOG4105C26 Dehydrogenase FOC96_RS25830 ENOG4105VFR signal peptidase FOC96_RS25835 ENOG4105DZ1 carboxypeptidase FOC96_RS25845 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC96_RS25860 ENOG4105RHA ABC transporter, permease FOC96_RS25865 ENOG4108IUX (ABC) transporter FOC96_RS25880 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC96_RS25940 ENOG4105VZ8 Transcriptional regulator FOC96_RS25950 ENOG4105C7S Dehydrogenase FOC96_RS26045 ENOG4105DDQ anthranilate synthase FOC96_RS26055 ENOG4105CK7 Sodium proline symporter FOC96_RS26095 ENOG4105EKQ RNA-directed DNA polymerase FOC96_RS26140 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC96_RS26150 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC96_RS26155 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC96_RS26175 ENOG4107TVC Glycosyl transferase, family 2 FOC96_RS26195 ENOG4105K64 Glycosyl transferase, family 2 FOC96_RS26215 ENOG4105EMS pseudouridine synthase FOC96_RS26235 ENOG4105MIX Adenylate cyclase FOC96_RS26240 ENOG4108Z18 K06886 hemoglobin FOC96_RS26255 ENOG4105DPN Oligoendopeptidase f FOC96_RS26265 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC96_RS26275 ENOG4108ZCF integral membrane protein FOC96_RS26295 ENOG4105UQX Mate efflux family protein FOC96_RS26300 ENOG4108JQ7 (ABC) transporter FOC96_RS26310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC96_RS26315 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC96_RS26330 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC96_RS26345 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC96_RS26350 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC96_RS26375 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC96_RS26385 ENOG4108KP7 hydrolase FOC96_RS26395 ENOG41073B9 FOC96_RS26400 ENOG4107AYK membrAne FOC96_RS26410 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC96_RS26420 ENOG4105QNR S1 RNA binding domain protein FOC96_RS26440 ENOG4105BZU Histidine kinase FOC96_RS26445 ENOG4105CH6 catalase FOC96_RS26450 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC96_RS26455 ENOG4105CAQ asparagine synthetase FOC96_RS26480 ENOG4105ERH Fumarylacetoacetate hydrolase FOC96_RS26545 ENOG4105XVF Competence transcription factor FOC96_RS26575 ENOG4107QP3 malate synthase g FOC96_RS26600 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC96_RS26620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC96_RS26630 ENOG41086D8 Transcriptional regulator FOC96_RS26635 ENOG4108AEY RNA polymerase sigma factor FOC96_RS26645 ENOG4107TVP HD domain protein FOC96_RS26655 ENOG4107RN3 metallophosphoesterase FOC96_RS26660 ENOG4105ENX hydrolase FOC96_RS26665 ENOG4105ST3 Transcriptional regulator FOC96_RS26715 ENOG4105CEY Amp-dependent synthetase and ligase FOC96_RS26725 ENOG4105DF9 Lipoate-protein, ligase FOC96_RS26730 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC96_RS26735 ENOG4106AXD FOC96_RS26760 ENOG4105ECB domain protein FOC96_RS26775 ENOG4105NA0 Transcriptional regulator FOC96_RS26805 ENOG4105C1Q protoporphyrinogen oxidase FOC96_RS26820 ENOG4105BZ4 penicillin-binding protein FOC96_RS26825 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC96_RS26830 ENOG4105CKV Membrane FOC96_RS26835 ENOG410905X membrane-flanked domain protein FOC96_RS26855 ENOG41060BG Tetr family transcriptional regulator FOC96_RS26875 ENOG4105CKV Membrane FOC96_RS26880 ENOG410905X membrane-flanked domain protein FOC96_RS26915 ENOG4105K59 histidine triad (HIT) protein FOC96_RS26940 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC96_RS26945 ENOG4105EEM helicase FOC96_RS26955 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC96_RS26960 ENOG4105C57 major facilitator superfamily FOC96_RS26985 ENOG4105EMN RNA polymerase sigma factor FOC96_RS27005 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC96_RS27020 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC96_RS27040 ENOG4108MUZ hydrolase FOC96_RS27095 ENOG4106D4I domain protein FOC96_RS27100 ENOG4107VRP DNA repair exonuclease FOC96_RS27165 ENOG4105BZU Histidine kinase FOC96_RS27170 ENOG4105BZU Histidine kinase FOC96_RS27175 ENOG4108MJI response regulator FOC96_RS27185 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC96_RS27195 ENOG4105WN5 stage II sporulation protein FOC96_RS27260 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC96_RS27270 ENOG410780I phosphoprotein phosphatase activity FOC96_RS27285 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC96_RS27290 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC96_RS27295 ENOG4105CMT Dihydroxyacetone kinase FOC96_RS27305 ENOG4105CMT Dihydroxyacetone kinase FOC96_RS27335 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC96_RS27350 ENOG4108IG5 Transcriptional regulator FOC96_RS27355 ENOG4107P5I polyketide synthase FOC96_RS27415 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC96_RS27445 ENOG4105CDU Replicative dna helicase FOC96_RS27515 ENOG4105C0D helicase FOC96_RS27575 ENOG4108MRH transcriptional regulatory protein FOC96_RS27585 ENOG4105CSH Transporter FOC96_RS27605 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC96_RS27635 ENOG4108JQ7 (ABC) transporter FOC96_RS27645 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC96_RS27685 ENOG4105CTU Proline racemase FOC96_RS27695 ENOG4108FPN Integrase FOC96_RS27710 ENOG4105G7B Protein of unknown function (DUF2992) FOC96_RS27715 ENOG41086D8 Transcriptional regulator FOC96_RS27735 ENOG4105DER m42 family FOC96_RS27760 ENOG4105CGU Enoyl-CoA hydratase FOC96_RS27770 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC96_RS27780 ENOG4106AKK s-layer domain-containing protein FOC96_RS27785 ENOG4106AKK s-layer domain-containing protein FOC96_RS27825 ENOG4105CHH sulfate transporter FOC96_RS27840 ENOG4105D4P Coproporphyrinogen iii oxidase FOC96_RS27845 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC96_RS27865 ENOG4107FQX Alpha-acetolactate decarboxylase FOC96_RS27900 ENOG410839P FOC96_RS27915 ENOG4105CDA abc transporter atp-binding protein FOC96_RS27920 ENOG4105DRP amino acid AbC transporter FOC96_RS27930 ENOG4105BZ1 (ABC) transporter FOC96_RS27935 ENOG4105BZ1 (ABC) transporter FOC96_RS27940 ENOG4105C26 Dehydrogenase FOC96_RS27950 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC96_RS27955 ENOG4105D5Q Arginine ornithine antiporter FOC96_RS27965 ENOG4105CH6 catalase FOC96_RS27970 ENOG4107RKG DJ-1/PfpI family FOC96_RS27980 ENOG4105E5W Transporter FOC96_RS27985 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC96_RS28005 ENOG4105KPY Small multidrug resistance protein FOC96_RS28020 ENOG4108YXU transcriptional regulator AsnC family FOC96_RS28065 ENOG4106KNT transcriptional regulator FOC96_RS28075 ENOG4107RWR Sodium hydrogen exchanger FOC96_RS28080 ENOG4105CUB amino acid FOC96_RS28115 ENOG4107T5V SNARE associated Golgi FOC96_RS28150 ENOG4105WEF catalase FOC96_RS28185 ENOG4105C19 ABC transporter FOC96_RS28190 ENOG4107RBB ABC transporter, permease FOC96_RS28195 ENOG41069ER domain protein FOC96_RS28215 ENOG4105VZJ PTS System FOC96_RS28220 ENOG4105VCP PTS System FOC96_RS28225 ENOG4105EMD TRANSCRIPTIONal FOC96_RS28250 ENOG4108KGH TRANSCRIPTIONal FOC96_RS28260 ENOG41087NI Sulfite exporter TauE/SafE FOC96_RS28265 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC96_RS28275 ENOG41085GJ domain protein FOC96_RS28280 ENOG4105VFE sira family FOC96_RS28285 ENOG4107TPS domain protein FOC96_RS28290 ENOG4105VFE sira family FOC96_RS28295 ENOG4105XTG Pfam:DUF156 FOC96_RS28300 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC96_RS28305 ENOG4105ED1 spovr family FOC96_RS28310 ENOG4107Y03 Nitroreductase FOC96_RS28330 ENOG4108B31 Spore germination protein FOC96_RS28365 ENOG4105C5Y PTS System FOC96_RS28385 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC96_RS28395 ENOG4105C7N Xanthine uracil vitamin C permease FOC96_RS28405 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC96_RS28430 ENOG4108INS Transcriptional regulator FOC96_RS28480 ENOG4105DWF phosphomethylpyrimidine kinase FOC96_RS28485 ENOG4105D06 uba thif-type nad fad binding protein FOC96_RS28500 ENOG41080HI glycine oxidase FOC96_RS28505 ENOG4108VEU Thiamine monophosphate synthase FOC96_RS28515 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC96_RS28525 ENOG4105ETU transcriptional activator (TenA FOC96_RS28545 ENOG41080XQ Signal transduction protein with cbs domains FOC96_RS28675 ENOG4105E2Z phosphate ABC transporter (Permease FOC96_RS28680 ENOG4105C8U phosphate abc transporter FOC96_RS28685 ENOG4105CVA phosphate FOC96_RS28690 ENOG4105CE1 Ferrous iron transport protein b FOC96_RS28695 ENOG4105CE1 Ferrous iron transport protein b FOC96_RS28700 ENOG4105CE1 Ferrous iron transport protein b FOC96_RS28705 ENOG4108NHD germination protein FOC96_RS28720 ENOG4105E1V na solute symporter FOC96_RS28725 ENOG4106CAD Protein of unknown function (DUF3311) FOC96_RS28740 ENOG4105E2S oxidase) subunit II FOC96_RS28745 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC96_RS28770 ENOG4105MA6 gCN5-related N-acetyltransferase FOC96_RS28785 ENOG4105C7N Xanthine uracil vitamin C permease FOC96_RS28790 ENOG4105C85 amino acid FOC96_RS28810 ENOG4105DUX Transporter FOC96_RS28820 ENOG4107D63 FOC96_RS28825 ENOG4105VZ8 Transcriptional regulator FOC96_RS28830 ENOG41069ER domain protein FOC96_RS28835 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC96_RS28900 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC96_RS28905 ENOG4105CNN ABC, transporter FOC96_RS28920 ENOG4108RVA ribokinase FOC96_RS28925 ENOG4105ETE Transcriptional regulator (LacI family FOC96_RS28930 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC96_RS28935 ENOG41067TZ transcriptional regulator, MarR family FOC96_RS28940 ENOG4105CXY transporter FOC96_RS28950 ENOG4108JQ7 (ABC) transporter FOC96_RS28955 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC96_RS28965 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC96_RS28975 ENOG41068KF Universal stress protein FOC96_RS28980 ENOG4105CHH sulfate transporter FOC96_RS28990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS28995 ENOG4105BZU Histidine kinase FOC96_RS29000 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC96_RS29005 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC96_RS29015 ENOG4105GFR rna polymerase sigma factor FOC96_RS29030 ENOG4108IQI permease FOC96_RS29035 ENOG4105DRP amino acid AbC transporter FOC96_RS29040 ENOG4105EAD ABC transporter FOC96_RS29045 ENOG4105CT1 (ABC) transporter FOC96_RS29050 ENOG4105CDA abc transporter atp-binding protein FOC96_RS29055 ENOG4105BZG amino acid carrier protein FOC96_RS29060 ENOG4105CRN Aminoglycoside phosphotransferase FOC96_RS29075 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC96_RS29080 ENOG4105WH1 Two component transcriptional regulator luxr family FOC96_RS29085 ENOG4108XG2 Histidine kinase FOC96_RS29090 ENOG4105E1K spore germination protein FOC96_RS29105 ENOG4105CG3 alpha amylase, catalytic region FOC96_RS29110 ENOG4105C5Y PTS System FOC96_RS29115 ENOG4107414 GntR family transcriptional regulator FOC96_RS29120 ENOG4105D5Q Arginine ornithine antiporter FOC96_RS29125 ENOG4105BZU Histidine kinase FOC96_RS29135 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC96_RS29140 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC96_RS29145 ENOG4107T89 von Willebrand factor, type A FOC96_RS29155 ENOG4105EXW epimerase dehydratase FOC96_RS29170 ENOG4105E0A ABC, transporter FOC96_RS29175 ENOG4108IHU transport system permease protein FOC96_RS29180 ENOG4105DQ5 transport system permease protein FOC96_RS29185 ENOG4108MES Periplasmic binding protein FOC96_RS29190 ENOG4105DUX Transporter FOC96_RS29205 ENOG4105DAA L-lactate FOC96_RS29210 ENOG4108IJ0 Aspartate ammonia-lyase FOC96_RS29215 ENOG4105C37 (CBS) domain FOC96_RS29220 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC96_RS29225 ENOG4105D9N nucleoside FOC96_RS29230 ENOG4108KGH TRANSCRIPTIONal FOC96_RS29235 ENOG41073R8 VanW family FOC96_RS29270 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC96_RS29275 ENOG4105C59 p-type ATPase FOC96_RS29285 ENOG4105CUB amino acid FOC96_RS29305 ENOG4108JB9 formate dehydrogenase FOC96_RS29310 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC96_RS29315 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC96_RS29320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC96_RS29325 ENOG4105BZU Histidine kinase FOC96_RS29335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC96_RS29340 ENOG4108UZ3 Transporter FOC96_RS29350 ENOG4105C6K Malic enzyme FOC96_RS29360 ENOG4108MRH transcriptional regulatory protein FOC96_RS29385 ENOG4105US7 Histidine kinase FOC96_RS29390 ENOG4108STX response regulator FOC96_RS29395 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC96_RS29415 ENOG4105D4T Citrate transporter FOC96_RS29420 ENOG4108V9W transcriptional regulatory protein FOC96_RS29425 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC96_RS29435 ENOG4105DZ6 Band 7 protein FOC96_RS29450 ENOG4105C94 Transporter FOC96_RS29470 ENOG4105CYN Serine protein kinase FOC96_RS29480 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC96_RS29490 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC96_RS29505 ENOG4107ZQN disulfide bond FOC96_RS29510 ENOG4108JQC penicillin-binding protein 1A FOC96_RS29525 ENOG4105BZ1 (ABC) transporter FOC96_RS29660 ENOG4105G5W regulator Fur family FOC96_RS29665 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC96_RS29685 ENOG4108IUW ABC transporter FOC96_RS29695 ENOG4105CBC glutamate synthase FOC96_RS29700 ENOG4107NBY Membrane FOC96_RS29705 ENOG4105BZ1 (ABC) transporter FOC96_RS29725 ENOG4106BXE FOC96_RS29730 ENOG4105CEN a g-specific adenine glycosylase FOC96_RS29735 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC96_RS29765 ENOG4105ECP epimerase FOC96_RS29770 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC96_RS29790 ENOG4105F1A Pyruvate formate-lyase FOC96_RS29810 ENOG4105C3I Nad-dependent epimerase dehydratase FOC96_RS29815 ENOG4107QQG Dehydrogenase FOC96_RS29820 ENOG4105CKK Glycosyl transferase, family 2 FOC96_RS29835 ENOG4108A04 Beta-lactamase FOC96_RS29875 ENOG4108IQI permease FOC96_RS29885 ENOG4108JUB Transcriptional regulator FOC96_RS29935 ENOG4105UPD Calcium Proton FOC96_RS29940 ENOG410606W general stress protein FOC96_RS29955 ENOG4107ZTW SNARE associated Golgi FOC96_RS29965 ENOG4105C3F Signal peptidase i FOC96_RS29975 ENOG4108IPJ Membrane FOC96_RS29980 ENOG4105C59 p-type ATPase FOC96_RS29985 ENOG4107U9T Pfam:Ribonuclease_BN FOC96_RS29995 ENOG4105KJF protein tyrosine phosphatase FOC96_RS30015 ENOG4108TTB tellurium resistance protein FOC96_RS30020 ENOG4107TS3 membrane protein, TerC FOC96_RS30025 ENOG4106FN3 tellurium resistance protein FOC96_RS30030 ENOG4106FN3 tellurium resistance protein FOC96_RS30035 ENOG4108N0M stress protein FOC96_RS30065 ENOG4105DEU major facilitator superfamily FOC96_RS30085 ENOG41062JF Transcriptional regulator FOC96_RS30115 ENOG4105C5H ABC transporter FOC96_RS30130 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC96_RS30145 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC96_RS30175 ENOG4105CI1 PTS System FOC96_RS30185 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC96_RS30190 ENOG4105C8Q Methyl-accepting chemotaxis FOC96_RS30200 ENOG4105EAB amino acid AbC transporter FOC96_RS30205 ENOG4105E5Q amino acid AbC transporter FOC96_RS30220 ENOG4105D2S major facilitator superfamily FOC96_RS30225 ENOG410756H nucleotidyltransferase FOC96_RS30245 ENOG4105BZU Histidine kinase FOC96_RS30265 ENOG4106UIA FOC96_RS30270 ENOG4106UIA FOC96_RS30290 ENOG4108V5C ABC transporter FOC96_RS30295 ENOG4105DQ5 transport system permease protein FOC96_RS30300 ENOG4105EHG Permease protein FOC96_RS30320 ENOG4105D3R alkyl hydroperoxide reductase FOC96_RS30345 ENOG4105DFD Na H antiporter FOC96_RS30355 ENOG4105DTQ mandelate racemase muconate lactonizing FOC96_RS30370 ENOG4108W15 Protein of unknown function (DUF1456) FOC96_RS30375 ENOG4105BZU Histidine kinase FOC96_RS30385 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC96_RS30390 ENOG4105D9N nucleoside FOC96_RS30410 ENOG4105KPY Small multidrug resistance protein FOC96_RS30415 ENOG4105C26 Dehydrogenase FOC96_RS30425 ENOG4108JPW Aminotransferase FOC96_RS30430 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC96_RS30435 ENOG4105CBD Diacylglycerol kinase FOC96_RS30455 ENOG4107I77 yiaA/B two helix domain FOC96_RS30460 ENOG410834F Transcriptional regulator FOC96_RS30480 ENOG4105D01 (LipO)protein FOC96_RS30485 ENOG4108UMI ABC transporter, permease FOC96_RS30495 ENOG4108W2Y isochorismatase FOC96_RS30520 ENOG4105C4R Atp-dependent dna helicase FOC96_RS30545 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC96_RS30555 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC96_RS30580 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC96_RS30590 ENOG4105C83 adenylosuccinate lyase FOC96_RS30595 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC96_RS30600 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC96_RS30625 ENOG4105SX7 Transporter FOC96_RS30645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC96_RS30715 ENOG4107ZXU DSBA oxidoreductase FOC96_RS30740 ENOG4105BZU Histidine kinase FOC96_RS30810 ENOG4105WXW Antirepressor FOC96_RS30840 ENOG4106CVF DNA replication protein FOC96_RS30915 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC96_RS30965 ENOG4108MDF Phage Portal Protein FOC96_RS30970 ENOG4106CGH Phage Mu protein F like protein FOC96_RS31000 ENOG41060SN FOC96_RS31050 ENOG4105XSJ toxin secretion phage lysis holin FOC96_RS31075 ENOG4108FPN Integrase FOC96_RS31080 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC96_RS31105 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC96_RS31140 ENOG4107QJE Chromosome Partitioning Protein FOC96_RS31150 ENOG4107JM4 Tetratricopeptide repeat FOC96_RS31170 ENOG4105D0M Protease HtpX homolog