locus-tag	class	description
I6G75_RS00050	COG2311	Membrane
I6G75_RS00065	COG5386	Cell surface protein
I6G75_RS00075	COG4196	transglutaminase domain protein
I6G75_RS00080	COG0671	phosphoesterase, PA-phosphatase related
I6G75_RS00095	COG1215	transferase activity, transferring glycosyl groups
I6G75_RS00100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G75_RS00105	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6G75_RS00185	COG2356	endonuclease I
I6G75_RS00265	COG2002	toxin-antitoxin pair type II binding
I6G75_RS00275	COG4974	Belongs to the 'phage' integrase family
I6G75_RS00340	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G75_RS00350	COG4974	Belongs to the 'phage' integrase family
I6G75_RS00355	COG1074	ATP-dependent DNA helicase activity
I6G75_RS00620	COG5658	integral membrane protein
I6G75_RS00625	COG0640	Transcriptional regulator
I6G75_RS00630	COG1674	ftsk spoiiie
I6G75_RS00645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G75_RS00855	COG0017	Asparaginyl-tRNA synthetase
I6G75_RS00875	COG1674	ftsk spoiiie
I6G75_RS00975	COG1929	Belongs to the glycerate kinase type-1 family
I6G75_RS00980	COG0471	metal ion transport
I6G75_RS00985	COG0745	RESPONSE REGULATOR receiver
I6G75_RS00990	COG3850	Histidine kinase
I6G75_RS00990	COG5002	protein histidine kinase activity
I6G75_RS01005	COG0733	neurotransmitter:sodium symporter activity
I6G75_RS01030	COG2610	gluconate transmembrane transporter activity
I6G75_RS01035	COG1454	alcohol dehydrogenase
I6G75_RS01040	COG1794	racemase activity, acting on amino acids and derivatives
I6G75_RS01050	COG0456	acetyltransferase
I6G75_RS01055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G75_RS01065	COG1131	(ABC) transporter
I6G75_RS01070	COG4473	ABC transporter
I6G75_RS01080	COG0546	phosphoglycolate phosphatase activity
I6G75_RS01100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G75_RS01105	COG3250	beta-galactosidase activity
I6G75_RS01120	COG0768	penicillin binding
I6G75_RS01130	COG0204	Acyl-transferase
I6G75_RS01135	COG1272	protein, Hemolysin III
I6G75_RS01145	COG0805	protein transport
I6G75_RS01155	COG1307	EDD domain protein, DegV family
I6G75_RS01160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6G75_RS01165	COG1999	signal sequence binding
I6G75_RS01170	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G75_RS01175	COG0367	asparagine synthase
I6G75_RS01195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G75_RS01200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G75_RS01220	COG1335	isochorismatase
I6G75_RS01225	COG1051	belongs to the nudix hydrolase family
I6G75_RS01235	COG0668	transmembrane transport
I6G75_RS01240	COG2203	Gaf domain
I6G75_RS01240	COG4585	Histidine kinase
I6G75_RS01245	COG2197	response regulator
I6G75_RS01255	COG1064	alcohol dehydrogenase
I6G75_RS01310	COG1125	glycine betaine transport
I6G75_RS01310	COG0517	IMP dehydrogenase activity
I6G75_RS01315	COG1174	glycine betaine transport
I6G75_RS01350	COG1253	flavin adenine dinucleotide binding
I6G75_RS01355	COG1012	belongs to the aldehyde dehydrogenase family
I6G75_RS01360	COG5506	Protein of unknown function (DUF1694)
I6G75_RS01375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G75_RS01380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G75_RS01385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G75_RS01390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G75_RS01395	COG0456	acetyltransferase
I6G75_RS01400	COG3829	transcription factor binding
I6G75_RS01405	COG1509	lysine 2,3-aminomutase activity
I6G75_RS01440	COG0515	serine threonine protein kinase
I6G75_RS01440	COG4991	sh3 domain protein
I6G75_RS01440	COG3064	Membrane
I6G75_RS01445	COG4326	sporulation control protein
I6G75_RS01450	COG0671	phosphoesterase, PA-phosphatase related
I6G75_RS01455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G75_RS01460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G75_RS01520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G75_RS01550	COG0300	oxidoreductase activity
I6G75_RS01570	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6G75_RS01570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G75_RS01580	COG4841	protein insertion into membrane
I6G75_RS01585	COG0372	Belongs to the citrate synthase family
I6G75_RS01590	COG2079	MmgE PrpD family protein
I6G75_RS01595	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6G75_RS01600	COG1960	acyl-CoA dehydrogenase activity
I6G75_RS01605	COG2084	Dehydrogenase
I6G75_RS01615	COG1280	lysine exporter protein (LysE YggA)
I6G75_RS01620	COG1024	Enoyl-CoA hydratase
I6G75_RS01635	COG0420	3'-5' exonuclease activity
I6G75_RS01640	COG0419	ATPase involved in DNA repair
I6G75_RS01660	COG2223	nitrite transmembrane transporter activity
I6G75_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS01670	COG1169	isochorismate synthase
I6G75_RS01675	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6G75_RS01680	COG1535	isochorismatase
I6G75_RS01680	COG3433	isochorismatase activity
I6G75_RS01685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G75_RS01690	COG3251	PFAM MbtH domain protein
I6G75_RS01695	COG2814	Major facilitator Superfamily
I6G75_RS01710	COG0776	regulation of translation
I6G75_RS01720	COG2318	DinB family
I6G75_RS01730	COG1115	amino acid carrier protein
I6G75_RS01745	COG2329	Antibiotic biosynthesis monooxygenase
I6G75_RS01750	COG1187	pseudouridine synthase activity
I6G75_RS01755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G75_RS01765	COG1136	(ABC) transporter
I6G75_RS01775	COG0596	Alpha beta hydrolase
I6G75_RS01780	COG2814	Major facilitator Superfamily
I6G75_RS01800	COG2226	methyltransferase
I6G75_RS01845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS01880	COG1247	-acetyltransferase
I6G75_RS01910	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6G75_RS01920	COG2226	methyltransferase
I6G75_RS01925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G75_RS01935	COG1278	Cold shock
I6G75_RS01950	COG0010	Belongs to the arginase family
I6G75_RS01960	COG0583	DNA-binding transcription factor activity
I6G75_RS01965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G75_RS01980	COG0583	DNA-binding transcription factor activity
I6G75_RS01985	COG2258	MOSC domain
I6G75_RS02000	COG1132	(ABC) transporter
I6G75_RS02005	COG1132	(ABC) transporter
I6G75_RS02025	COG1396	sequence-specific DNA binding
I6G75_RS02055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G75_RS02065	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6G75_RS02070	COG1595	DNA-templated transcription, initiation
I6G75_RS02095	COG1649	PFAM Uncharacterised BCR, COG1649
I6G75_RS02120	COG2971	BadF BadG BcrA BcrD
I6G75_RS02130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6G75_RS02165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS02195	COG1309	transcriptional regulator
I6G75_RS02210	COG0577	efflux transmembrane transporter activity
I6G75_RS02210	COG1136	(ABC) transporter
I6G75_RS02215	COG3615	Tellurite resistance protein tehB
I6G75_RS02215	COG0500	methyltransferase
I6G75_RS02305	COG1846	Transcriptional regulator
I6G75_RS02340	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G75_RS02350	COG0110	maltose O-acetyltransferase activity
I6G75_RS02365	COG0768	penicillin binding
I6G75_RS02370	COG1595	DNA-templated transcription, initiation
I6G75_RS02380	COG0768	penicillin binding
I6G75_RS02385	COG0768	penicillin binding
I6G75_RS02390	COG2367	Beta-lactamase
I6G75_RS02400	COG1609	Transcriptional regulator
I6G75_RS02405	COG2814	Major facilitator Superfamily
I6G75_RS02410	COG0673	inositol 2-dehydrogenase activity
I6G75_RS02440	COG3718	enzyme involved in inositol metabolism
I6G75_RS02465	COG0737	Belongs to the 5'-nucleotidase family
I6G75_RS02475	COG0457	Tetratricopeptide repeat
I6G75_RS02480	COG1476	TRANSCRIPTIONal
I6G75_RS02495	COG1876	peptidase activity
I6G75_RS02515	COG1309	transcriptional regulator
I6G75_RS02520	COG0488	(ABC) transporter
I6G75_RS02525	COG3300	MHYT domain
I6G75_RS02525	COG5001	Diguanylate cyclase
I6G75_RS02530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G75_RS02555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G75_RS02585	COG1960	acyl-CoA dehydrogenase activity
I6G75_RS02590	COG0439	Biotin carboxylase
I6G75_RS02595	COG0511	ligase activity, forming carbon-carbon bonds
I6G75_RS02600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G75_RS02605	COG1024	Enoyl-CoA hydratase
I6G75_RS02610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G75_RS02615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G75_RS02630	COG0572	uridine kinase
I6G75_RS02640	COG2318	DinB family
I6G75_RS02645	COG1686	Belongs to the peptidase S11 family
I6G75_RS02670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G75_RS02690	COG3227	Zinc metalloprotease (Elastase)
I6G75_RS02710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G75_RS02710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G75_RS02735	COG2814	Major facilitator Superfamily
I6G75_RS02745	COG2226	methyltransferase
I6G75_RS02780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G75_RS02825	COG3386	PFAM SMP-30 Gluconolaconase
I6G75_RS02835	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I6G75_RS02840	COG3773	Cell wall hydrolase
I6G75_RS02850	COG0745	RESPONSE REGULATOR receiver
I6G75_RS02855	COG2205	protein histidine kinase activity
I6G75_RS02865	COG0488	(ABC) transporter
I6G75_RS02880	COG1136	(ABC) transporter
I6G75_RS02885	COG0577	efflux transmembrane transporter activity
I6G75_RS02905	COG0460	homoserine dehydrogenase
I6G75_RS02910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G75_RS02920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G75_RS02995	COG2124	cytochrome p450
I6G75_RS03030	COG0561	phosphatase activity
I6G75_RS03035	COG5002	protein histidine kinase activity
I6G75_RS03040	COG0768	penicillin binding
I6G75_RS03045	COG1819	glycosyl
I6G75_RS03050	COG1794	racemase activity, acting on amino acids and derivatives
I6G75_RS03075	COG2205	protein histidine kinase activity
I6G75_RS03085	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G75_RS03090	COG0604	alcohol dehydrogenase
I6G75_RS03095	COG0671	phosphoesterase, PA-phosphatase related
I6G75_RS03100	COG0768	penicillin binding
I6G75_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS03120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G75_RS03155	COG0693	protein deglycase activity
I6G75_RS03175	COG2814	Major facilitator Superfamily
I6G75_RS03190	COG0584	glycerophosphoryl diester phosphodiesterase
I6G75_RS03205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G75_RS03210	COG0697	spore germination
I6G75_RS03235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G75_RS03245	COG2223	nitrite transmembrane transporter activity
I6G75_RS03250	COG2816	NAD+ diphosphatase activity
I6G75_RS03255	COG0592	DNA-directed DNA polymerase activity
I6G75_RS03260	COG1051	belongs to the nudix hydrolase family
I6G75_RS03285	COG0406	alpha-ribazole phosphatase activity
I6G75_RS03295	COG3878	Protein conserved in bacteria
I6G75_RS03315	COG4667	esterase of the alpha-beta hydrolase superfamily
I6G75_RS03340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G75_RS03355	COG0322	excinuclease ABC activity
I6G75_RS03390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G75_RS03430	COG1523	belongs to the glycosyl hydrolase 13 family
I6G75_RS03435	COG3227	Zinc metalloprotease (Elastase)
I6G75_RS03455	COG0346	lactoylglutathione lyase activity
I6G75_RS03460	COG0201	protein transport
I6G75_RS03470	COG0697	spore germination
I6G75_RS03475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G75_RS03510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G75_RS03525	COG2959	enzyme of heme biosynthesis
I6G75_RS03560	COG1309	transcriptional regulator
I6G75_RS03590	COG3284	Transcriptional regulator
I6G75_RS03605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G75_RS03610	COG1349	DNA-binding transcription factor activity
I6G75_RS03630	COG1959	2 iron, 2 sulfur cluster binding
I6G75_RS03645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G75_RS03650	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G75_RS03655	COG0022	dehydrogenase e1 component
I6G75_RS03660	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G75_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS03675	COG0456	acetyltransferase
I6G75_RS03675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G75_RS03680	COG0572	uridine kinase
I6G75_RS03690	COG0494	nUDIX hydrolase
I6G75_RS03715	COG4176	ABC-type proline glycine betaine transport system permease component
I6G75_RS03720	COG4175	Glycine betaine
I6G75_RS03720	COG0517	IMP dehydrogenase activity
I6G75_RS03745	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6G75_RS03750	COG2153	protein acetylation
I6G75_RS03755	COG3397	chitin binding
I6G75_RS03765	COG2205	protein histidine kinase activity
I6G75_RS03770	COG2226	methyltransferase
I6G75_RS03775	COG2315	Protein conserved in bacteria
I6G75_RS03780	COG2153	protein acetylation
I6G75_RS03785	COG0658	competence protein
I6G75_RS03785	COG2333	competence protein COMEC
I6G75_RS03835	COG3973	AAA domain
I6G75_RS03850	COG2105	PFAM AIG2 family protein
I6G75_RS03855	COG0514	ATP-dependent DNA helicase (RecQ)
I6G75_RS03880	COG4637	Psort location Cytoplasmic, score
I6G75_RS03905	COG3397	chitin binding
I6G75_RS03920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G75_RS03925	COG1115	amino acid carrier protein
I6G75_RS03930	COG1012	belongs to the aldehyde dehydrogenase family
I6G75_RS03935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G75_RS03945	COG3938	Belongs to the proline racemase family
I6G75_RS03950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G75_RS03990	COG0586	Pfam SNARE associated Golgi protein
I6G75_RS04005	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6G75_RS04010	COG0519	Catalyzes the synthesis of GMP from XMP
I6G75_RS04015	COG4166	transmembrane transport
I6G75_RS04025	COG4948	Mandelate Racemase Muconate Lactonizing
I6G75_RS04070	COG2936	dipeptidyl-peptidase activity
I6G75_RS04075	COG5002	protein histidine kinase activity
I6G75_RS04080	COG0745	RESPONSE REGULATOR receiver
I6G75_RS04110	COG1164	Oligoendopeptidase f
I6G75_RS04115	COG0531	amino acid
I6G75_RS04120	COG1522	sequence-specific DNA binding
I6G75_RS04125	COG1307	EDD domain protein, DegV family
I6G75_RS04160	COG2814	Major facilitator Superfamily
I6G75_RS04170	COG1664	Polymer-forming cytoskeletal
I6G75_RS04175	COG0789	Transcriptional regulator
I6G75_RS04180	COG4533	DNA binding
I6G75_RS04185	COG0477	Major facilitator Superfamily
I6G75_RS04185	COG2814	Major facilitator Superfamily
I6G75_RS04205	COG2261	transglycosylase associated protein
I6G75_RS04220	COG2226	methyltransferase
I6G75_RS04250	COG0436	Aminotransferase
I6G75_RS04255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G75_RS04260	COG5146	pantothenate kinase activity
I6G75_RS04265	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6G75_RS04280	COG1131	(ABC) transporter
I6G75_RS04325	COG0628	permease
I6G75_RS04335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G75_RS04340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G75_RS04345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G75_RS04360	COG2816	NAD+ diphosphatase activity
I6G75_RS04380	COG2746	aminoglycoside 3-N-acetyltransferase activity
I6G75_RS04405	COG0697	spore germination
I6G75_RS04410	COG2318	DinB family
I6G75_RS04450	COG0861	Integral membrane protein TerC family
I6G75_RS04455	COG1368	sulfuric ester hydrolase activity
I6G75_RS04460	COG0488	(ABC) transporter
I6G75_RS04470	COG1033	growth of symbiont in host cell
I6G75_RS04470	COG2409	Drug exporters of the RND superfamily
I6G75_RS04475	COG1309	transcriptional regulator
I6G75_RS04490	COG0287	Prephenate dehydrogenase
I6G75_RS04495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G75_RS04505	COG1605	Chorismate mutase
I6G75_RS04505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6G75_RS04545	COG3584	3D domain protein
I6G75_RS04545	COG1388	LysM domain
I6G75_RS04555	COG2610	gluconate transmembrane transporter activity
I6G75_RS04560	COG1024	Enoyl-CoA hydratase
I6G75_RS04570	COG3290	protein histidine kinase activity
I6G75_RS04570	COG3829	transcription factor binding
I6G75_RS04585	COG1879	ABC-type sugar transport system periplasmic component
I6G75_RS04595	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G75_RS04605	COG2390	Transcriptional regulator
I6G75_RS04610	COG1070	Carbohydrate kinase
I6G75_RS04645	COG2329	Antibiotic biosynthesis monooxygenase
I6G75_RS04665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G75_RS04680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G75_RS04685	COG4187	Peptidase family M20/M25/M40
I6G75_RS04690	COG1414	Transcriptional regulator
I6G75_RS04695	COG0833	amino acid
I6G75_RS04700	COG1690	Belongs to the RtcB family
I6G75_RS04705	COG3239	Fatty acid desaturase
I6G75_RS04710	COG1785	Belongs to the alkaline phosphatase family
I6G75_RS04720	COG3655	Transcriptional regulator
I6G75_RS04735	COG4377	Putative membrane peptidase family (DUF2324)
I6G75_RS04745	COG3279	Response regulator of the LytR AlgR family
I6G75_RS04755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G75_RS04760	COG0346	lactoylglutathione lyase activity
I6G75_RS04780	COG0714	Associated with various cellular activities
I6G75_RS04805	COG0463	Glycosyl transferase, family 2
I6G75_RS04820	COG0463	Glycosyl transferase, family 2
I6G75_RS04830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G75_RS04835	COG0753	catalase activity
I6G75_RS04845	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6G75_RS04875	COG0778	Nitroreductase
I6G75_RS04880	COG1846	Transcriptional regulator
I6G75_RS04915	COG1725	Transcriptional regulator
I6G75_RS04935	COG0577	efflux transmembrane transporter activity
I6G75_RS04935	COG1136	(ABC) transporter
I6G75_RS04960	COG2207	Transcriptional regulator
I6G75_RS04965	COG0456	acetyltransferase
I6G75_RS04985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G75_RS05010	COG0642	Histidine kinase
I6G75_RS05015	COG0745	RESPONSE REGULATOR receiver
I6G75_RS05020	COG0596	Alpha beta hydrolase
I6G75_RS05050	COG0730	response to heat
I6G75_RS05060	COG0833	amino acid
I6G75_RS05070	COG4335	DNA alkylation repair
I6G75_RS05100	COG0768	penicillin binding
I6G75_RS05105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G75_RS05135	COG1984	allophanate hydrolase subunit 2
I6G75_RS05140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G75_RS05145	COG1414	Transcriptional regulator
I6G75_RS05155	COG3142	Participates in the control of copper homeostasis
I6G75_RS05160	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G75_RS05165	COG0640	Transcriptional regulator
I6G75_RS05175	COG1960	acyl-CoA dehydrogenase activity
I6G75_RS05190	COG3314	Sporulation integral membrane protein YlbJ
I6G75_RS05215	COG3848	Pyruvate phosphate dikinase
I6G75_RS05215	COG0574	Belongs to the PEP-utilizing enzyme family
I6G75_RS05220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS05235	COG5577	PFAM Coat F domain
I6G75_RS05240	COG3403	YqcI/YcgG family
I6G75_RS05245	COG1280	lysine exporter protein (LysE YggA)
I6G75_RS05250	COG1113	amino acid transport
I6G75_RS05280	COG1063	alcohol dehydrogenase
I6G75_RS05295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G75_RS05310	COG0737	Belongs to the 5'-nucleotidase family
I6G75_RS05315	COG2329	Antibiotic biosynthesis monooxygenase
I6G75_RS05325	COG0598	Magnesium transport protein CorA
I6G75_RS05350	COG1063	alcohol dehydrogenase
I6G75_RS05360	COG2124	cytochrome p450
I6G75_RS05365	COG1309	transcriptional regulator
I6G75_RS05370	COG0657	acetylesterase activity
I6G75_RS05390	COG0415	Belongs to the DNA photolyase family
I6G75_RS05395	COG0288	reversible hydration of carbon dioxide
I6G75_RS05405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G75_RS05410	COG5609	conserved protein (DUF2294)
I6G75_RS05425	COG0714	Associated with various cellular activities
I6G75_RS05435	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G75_RS05440	COG2267	carboxylic ester hydrolase activity
I6G75_RS05445	COG4641	Protein conserved in bacteria
I6G75_RS05450	COG1136	(ABC) transporter
I6G75_RS05455	COG0577	efflux transmembrane transporter activity
I6G75_RS05470	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G75_RS05475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G75_RS05480	COG1121	(ABC) transporter
I6G75_RS05505	COG0798	PFAM Bile acid sodium symporter
I6G75_RS05510	COG0346	lactoylglutathione lyase activity
I6G75_RS05515	COG0640	Transcriptional regulator
I6G75_RS05530	COG0443	Heat shock 70 kDa protein
I6G75_RS05550	COG0346	lactoylglutathione lyase activity
I6G75_RS05590	COG2814	Major facilitator Superfamily
I6G75_RS05615	COG0745	RESPONSE REGULATOR receiver
I6G75_RS05620	COG5002	protein histidine kinase activity
I6G75_RS05620	COG3850	Histidine kinase
I6G75_RS05645	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6G75_RS05670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS05675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G75_RS05685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G75_RS05700	COG2309	aminopeptidase activity
I6G75_RS05715	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6G75_RS05730	COG0653	protein targeting
I6G75_RS05755	COG0577	efflux transmembrane transporter activity
I6G75_RS05770	COG5002	protein histidine kinase activity
I6G75_RS05770	COG3850	Histidine kinase
I6G75_RS05780	COG2364	Membrane
I6G75_RS05785	COG1846	Transcriptional regulator
I6G75_RS05790	COG0456	acetyltransferase
I6G75_RS05795	COG2808	Putative FMN-binding domain
I6G75_RS05800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G75_RS05805	COG2271	Major facilitator Superfamily
I6G75_RS05810	COG1556	Lactate utilization protein
I6G75_RS05815	COG1139	Iron-sulfur cluster binding protein
I6G75_RS05825	COG0583	DNA-binding transcription factor activity
I6G75_RS05850	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G75_RS05865	COG1252	NADH dehydrogenase
I6G75_RS05870	COG3227	Zinc metalloprotease (Elastase)
I6G75_RS05875	COG0584	glycerophosphoryl diester phosphodiesterase
I6G75_RS05935	COG0738	Major facilitator superfamily
I6G75_RS05940	COG0673	inositol 2-dehydrogenase activity
I6G75_RS05945	COG0561	phosphatase activity
I6G75_RS05950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G75_RS05955	COG1609	Transcriptional regulator
I6G75_RS05960	COG0457	Tetratricopeptide repeat
I6G75_RS05990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G75_RS06015	COG0814	amino acid
I6G75_RS06020	COG1760	l-serine dehydratase
I6G75_RS06025	COG1760	l-serine dehydratase
I6G75_RS06030	COG2184	nucleotidyltransferase activity
I6G75_RS06035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G75_RS06040	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6G75_RS06050	COG1335	isochorismatase
I6G75_RS06055	COG1522	sequence-specific DNA binding
I6G75_RS06060	COG0531	amino acid
I6G75_RS06075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G75_RS06095	COG1595	DNA-templated transcription, initiation
I6G75_RS06110	COG0662	Cupin 2, conserved barrel domain protein
I6G75_RS06115	COG2207	Transcriptional regulator
I6G75_RS06115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G75_RS06145	COG3409	Peptidoglycan-binding domain 1 protein
I6G75_RS06145	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6G75_RS06160	COG2814	Major facilitator Superfamily
I6G75_RS06200	COG0477	Major facilitator Superfamily
I6G75_RS06210	COG1846	Transcriptional regulator
I6G75_RS06215	COG2814	Major facilitator Superfamily
I6G75_RS06225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G75_RS06230	COG1131	(ABC) transporter
I6G75_RS06255	COG1309	transcriptional regulator
I6G75_RS06270	COG2031	fatty acid transporter
I6G75_RS06280	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G75_RS06310	COG1122	ATPase activity
I6G75_RS06315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6G75_RS06335	COG1288	antiporter activity
I6G75_RS06340	COG2356	endonuclease I
I6G75_RS06345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G75_RS06355	COG2197	response regulator
I6G75_RS06375	COG1733	regulation of RNA biosynthetic process
I6G75_RS06380	COG0778	Nitroreductase
I6G75_RS06400	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS06410	COG1131	(ABC) transporter
I6G75_RS06435	COG1011	Hydrolase
I6G75_RS06460	COG2365	Tyrosine phosphatase family
I6G75_RS06485	COG0346	lactoylglutathione lyase activity
I6G75_RS06490	COG1940	carbohydrate kinase activity
I6G75_RS06495	COG0738	Major facilitator superfamily
I6G75_RS06500	COG0110	maltose O-acetyltransferase activity
I6G75_RS06510	COG1136	(ABC) transporter
I6G75_RS06510	COG0577	efflux transmembrane transporter activity
I6G75_RS06530	COG0628	permease
I6G75_RS06550	COG2226	methyltransferase
I6G75_RS06560	COG0477	Major facilitator Superfamily
I6G75_RS06590	COG1253	flavin adenine dinucleotide binding
I6G75_RS06595	COG0789	Transcriptional regulator
I6G75_RS06600	COG0697	spore germination
I6G75_RS06605	COG1357	PFAM Pentapeptide repeats (8 copies)
I6G75_RS06615	COG2706	6-phosphogluconolactonase activity
I6G75_RS06620	COG1070	Carbohydrate kinase
I6G75_RS06630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G75_RS06635	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6G75_RS06645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G75_RS06650	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G75_RS06680	COG0814	amino acid
I6G75_RS06705	COG1393	Belongs to the ArsC family
I6G75_RS06715	COG2188	Transcriptional regulator
I6G75_RS06720	COG0673	inositol 2-dehydrogenase activity
I6G75_RS06735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS06755	COG0384	phenazine biosynthesis protein PhzF
I6G75_RS06780	COG0318	PFAM AMP-dependent synthetase and ligase
I6G75_RS06785	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G75_RS06790	COG1733	regulation of RNA biosynthetic process
I6G75_RS06820	COG1191	sigma factor activity
I6G75_RS06830	COG1266	CAAX protease self-immunity
I6G75_RS06835	COG1309	transcriptional regulator
I6G75_RS06855	COG3152	Membrane
I6G75_RS06905	COG1151	hydroxylamine reductase activity
I6G75_RS06915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS06920	COG3409	Peptidoglycan-binding domain 1 protein
I6G75_RS06920	COG3757	hydrolase, family 25
I6G75_RS06955	COG2072	flavoprotein involved in K transport
I6G75_RS06985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS07000	COG1695	Transcriptional regulator
I6G75_RS07010	COG1113	amino acid transport
I6G75_RS07015	COG2814	Major facilitator Superfamily
I6G75_RS07045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G75_RS07050	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G75_RS07065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G75_RS07070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G75_RS07075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G75_RS07080	COG3739	integral membrane protein
I6G75_RS07085	COG0384	phenazine biosynthesis protein PhzF
I6G75_RS07105	COG0583	DNA-binding transcription factor activity
I6G75_RS07125	COG1193	negative regulation of DNA recombination
I6G75_RS07145	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6G75_RS07150	COG1164	Oligoendopeptidase f
I6G75_RS07155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G75_RS07185	COG0584	glycerophosphoryl diester phosphodiesterase
I6G75_RS07210	COG0640	Transcriptional regulator
I6G75_RS07215	COG0604	alcohol dehydrogenase
I6G75_RS07225	COG0457	Tetratricopeptide repeat
I6G75_RS07235	COG2808	Putative FMN-binding domain
I6G75_RS07240	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G75_RS07250	COG0385	Bile acid
I6G75_RS07255	COG0277	FAD linked oxidase domain protein
I6G75_RS07290	COG1216	Glycosyl transferase, family 2
I6G75_RS07295	COG1024	Enoyl-CoA hydratase
I6G75_RS07305	COG1285	pathogenesis
I6G75_RS07320	COG2514	catechol 2,3-dioxygenase activity
I6G75_RS07325	COG2720	vancomycin resistance protein
I6G75_RS07365	COG0716	FMN binding
I6G75_RS07415	COG0739	heme binding
I6G75_RS07420	COG0741	lytic transglycosylase activity
I6G75_RS07425	COG3409	Peptidoglycan-binding domain 1 protein
I6G75_RS07425	COG3757	hydrolase, family 25
I6G75_RS07470	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS07480	COG0165	Argininosuccinate lyase
I6G75_RS07495	COG4145	pantothenate transmembrane transporter activity
I6G75_RS07505	COG1012	belongs to the aldehyde dehydrogenase family
I6G75_RS07510	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS07520	COG1657	PFAM Prenyltransferase squalene oxidase
I6G75_RS07525	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I6G75_RS07530	COG2962	Rard protein
I6G75_RS07535	COG3326	Membrane
I6G75_RS07550	COG0489	protein tyrosine kinase activity
I6G75_RS07560	COG0314	molybdopterin synthase activity
I6G75_RS07565	COG0303	'Molybdopterin
I6G75_RS07570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G75_RS07575	COG2116	formate transmembrane transporter activity
I6G75_RS07585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G75_RS07590	COG5609	conserved protein (DUF2294)
I6G75_RS07595	COG2427	Protein of unknown function (DUF1641)
I6G75_RS07600	COG3383	formate dehydrogenase (NAD+) activity
I6G75_RS07605	COG0697	spore germination
I6G75_RS07645	COG2226	methyltransferase
I6G75_RS07650	COG4166	transmembrane transport
I6G75_RS07655	COG4166	transmembrane transport
I6G75_RS07660	COG4166	transmembrane transport
I6G75_RS07665	COG1301	dicarboxylic acid transport
I6G75_RS07670	COG1316	TRANSCRIPTIONal
I6G75_RS07680	COG1595	DNA-templated transcription, initiation
I6G75_RS07695	COG1131	(ABC) transporter
I6G75_RS07705	COG0673	inositol 2-dehydrogenase activity
I6G75_RS07715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G75_RS07720	COG0187	DNA topoisomerase II activity
I6G75_RS07725	COG1832	CoA-binding protein
I6G75_RS07730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G75_RS07735	COG0745	RESPONSE REGULATOR receiver
I6G75_RS07755	COG4841	protein insertion into membrane
I6G75_RS07760	COG0824	Thioesterase
I6G75_RS07790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G75_RS07800	COG2274	protein secretion by the type I secretion system
I6G75_RS07805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G75_RS07835	COG2211	Major facilitator Superfamily
I6G75_RS07845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G75_RS07860	COG0183	Belongs to the thiolase family
I6G75_RS07865	COG0318	PFAM AMP-dependent synthetase and ligase
I6G75_RS07870	COG1268	BioY protein
I6G75_RS07875	COG0318	PFAM AMP-dependent synthetase and ligase
I6G75_RS07930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G75_RS07940	COG5002	protein histidine kinase activity
I6G75_RS07945	COG0400	carboxylic ester hydrolase activity
I6G75_RS07950	COG0346	lactoylglutathione lyase activity
I6G75_RS07955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G75_RS07960	COG0069	glutamate synthase activity
I6G75_RS07965	COG1902	pentaerythritol trinitrate reductase activity
I6G75_RS07970	COG1329	Transcriptional regulator
I6G75_RS07975	COG0010	Belongs to the arginase family
I6G75_RS08000	COG2226	methyltransferase
I6G75_RS08040	COG4846	Membrane protein involved in cytochrome C biogenesis
I6G75_RS08045	COG0785	Cytochrome C biogenesis protein
I6G75_RS08055	COG1473	amidohydrolase
I6G75_RS08065	COG1131	(ABC) transporter
I6G75_RS08075	COG0583	DNA-binding transcription factor activity
I6G75_RS08085	COG1346	cytolysis
I6G75_RS08100	COG0730	response to heat
I6G75_RS08110	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6G75_RS08110	COG3409	Peptidoglycan-binding domain 1 protein
I6G75_RS08125	COG1132	(ABC) transporter
I6G75_RS08130	COG1132	(ABC) transporter
I6G75_RS08155	COG3639	organic phosphonate transmembrane transporter activity
I6G75_RS08170	COG0737	Belongs to the 5'-nucleotidase family
I6G75_RS08180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G75_RS08200	COG1695	Transcriptional regulator
I6G75_RS08210	COG0174	glutamine synthetase
I6G75_RS08215	COG0789	Transcriptional regulator
I6G75_RS08220	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6G75_RS08225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G75_RS08230	COG2860	membrane
I6G75_RS08235	COG0464	growth
I6G75_RS08265	COG1388	LysM domain
I6G75_RS08265	COG3584	3D domain protein
I6G75_RS08270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G75_RS08270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G75_RS08270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G75_RS08275	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G75_RS08280	COG1349	DNA-binding transcription factor activity
I6G75_RS08285	COG1979	alcohol dehydrogenase
I6G75_RS08290	COG2322	membrane
I6G75_RS08300	COG1113	amino acid transport
I6G75_RS08315	COG1408	metallophosphoesterase
I6G75_RS08320	COG2116	formate transmembrane transporter activity
I6G75_RS08345	COG2217	Heavy metal translocating P-type atpase
I6G75_RS08350	COG2608	mercury ion transmembrane transporter activity
I6G75_RS08355	COG1937	Protein conserved in bacteria
I6G75_RS08365	COG2819	hydrolase of the alpha beta superfamily
I6G75_RS08370	COG1120	ATPase activity
I6G75_RS08375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G75_RS08380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G75_RS08385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G75_RS08390	COG0708	Exodeoxyribonuclease III
I6G75_RS08395	COG2169	Transcriptional regulator
I6G75_RS08400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G75_RS08405	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6G75_RS08415	COG2364	Membrane
I6G75_RS08430	COG2267	carboxylic ester hydrolase activity
I6G75_RS08435	COG0346	lactoylglutathione lyase activity
I6G75_RS08440	COG5001	Diguanylate cyclase
I6G75_RS08440	COG3300	MHYT domain
I6G75_RS08500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G75_RS08525	COG1404	Belongs to the peptidase S8 family
I6G75_RS08530	COG3773	Cell wall hydrolase
I6G75_RS08540	COG1368	sulfuric ester hydrolase activity
I6G75_RS08545	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G75_RS08555	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6G75_RS08575	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6G75_RS08585	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6G75_RS08590	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6G75_RS08590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6G75_RS08600	COG2359	stage V sporulation protein S
I6G75_RS08605	COG1692	metallophosphoesterase
I6G75_RS08625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G75_RS08630	COG1426	Protein conserved in bacteria
I6G75_RS08645	COG0300	oxidoreductase activity
I6G75_RS08650	COG0612	Peptidase, M16
I6G75_RS08655	COG0612	Peptidase, M16
I6G75_RS08660	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6G75_RS08665	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6G75_RS08670	COG3845	ABC transporter
I6G75_RS08675	COG1744	ABC transporter substrate-binding protein PnrA-like
I6G75_RS08680	COG2188	Transcriptional regulator
I6G75_RS08685	COG1674	ftsk spoiiie
I6G75_RS08695	COG0740	serine-type endopeptidase activity
I6G75_RS08700	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G75_RS08710	COG0527	aspartate kinase activity
I6G75_RS08715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G75_RS08720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G75_RS08725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G75_RS08730	COG1873	PFAM PRC-barrel domain
I6G75_RS08735	COG0612	Peptidase, M16
I6G75_RS08740	COG0726	polysaccharide deacetylase
I6G75_RS08755	COG0196	riboflavin kinase activity
I6G75_RS08770	COG1550	Protein conserved in bacteria
I6G75_RS08780	COG1358	cellular component organization or biogenesis
I6G75_RS08785	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6G75_RS08790	COG0195	Participates in both transcription termination and antitermination
I6G75_RS08820	COG0750	zinc metalloprotease
I6G75_RS08830	COG4589	Belongs to the CDS family
I6G75_RS08845	COG0528	UMP kinase activity
I6G75_RS08875	COG4974	Belongs to the 'phage' integrase family
I6G75_RS08885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G75_RS08890	COG0758	DNA mediated transformation
I6G75_RS08895	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G75_RS08935	COG1837	Belongs to the UPF0109 family
I6G75_RS08945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G75_RS08955	COG0552	protein localization to endoplasmic reticulum
I6G75_RS08960	COG1196	nuclear chromosome segregation
I6G75_RS08970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G75_RS08975	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS08980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G75_RS08995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G75_RS09000	COG1461	Dihydroxyacetone kinase
I6G75_RS09005	COG1302	Protein conserved in bacteria
I6G75_RS09020	COG1564	THIamine pyrophosphokinase
I6G75_RS09025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G75_RS09030	COG1162	GTPase activity
I6G75_RS09035	COG2815	serine threonine protein kinase
I6G75_RS09035	COG0515	serine threonine protein kinase
I6G75_RS09040	COG0631	protein serine/threonine phosphatase activity
I6G75_RS09050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G75_RS09050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G75_RS09060	COG0242	peptide deformylase activity
I6G75_RS09065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G75_RS09070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G75_RS09090	COG1561	YicC-like family, N-terminal region
I6G75_RS09095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G75_RS09105	COG0006	proline dipeptidase activity
I6G75_RS09125	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G75_RS09190	COG0564	pseudouridine synthase activity
I6G75_RS09210	COG3599	regulation of cell shape
I6G75_RS09215	COG2302	S4 RNA-binding domain
I6G75_RS09220	COG0762	integral membrane protein
I6G75_RS09230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G75_RS09235	COG1496	oxidoreductase activity
I6G75_RS09240	COG1873	PFAM PRC-barrel domain
I6G75_RS09245	COG1191	sigma factor activity
I6G75_RS09250	COG1191	sigma factor activity
I6G75_RS09260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G75_RS09265	COG0849	cell division
I6G75_RS09270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G75_RS09275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G75_RS09285	COG0772	Belongs to the SEDS family
I6G75_RS09300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G75_RS09305	COG0768	penicillin binding
I6G75_RS09310	COG0768	penicillin binding
I6G75_RS09315	COG4839	cell division protein FtsL
I6G75_RS09330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G75_RS09345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G75_RS09350	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G75_RS09360	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6G75_RS09365	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G75_RS09370	COG3314	Sporulation integral membrane protein YlbJ
I6G75_RS09380	COG0742	ribosomal rna small subunit methyltransferase
I6G75_RS09395	COG3679	Belongs to the UPF0342 family
I6G75_RS09400	COG0406	alpha-ribazole phosphatase activity
I6G75_RS09415	COG2340	Cysteine-rich secretory protein family
I6G75_RS09430	COG3336	cytochrome c oxidase
I6G75_RS09465	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6G75_RS09470	COG0772	Belongs to the SEDS family
I6G75_RS09480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G75_RS09485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6G75_RS09495	COG4896	Protein conserved in bacteria
I6G75_RS09510	COG1217	gtp-binding protein TYPA
I6G75_RS09520	COG0483	inositol monophosphate 1-phosphatase activity
I6G75_RS09540	COG1982	Orn Lys Arg decarboxylase major
I6G75_RS09590	COG0022	dehydrogenase e1 component
I6G75_RS09595	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G75_RS09605	COG0242	peptide deformylase activity
I6G75_RS09610	COG0561	phosphatase activity
I6G75_RS09620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G75_RS09625	COG0569	domain protein
I6G75_RS09645	COG0583	DNA-binding transcription factor activity
I6G75_RS09650	COG0517	IMP dehydrogenase activity
I6G75_RS09660	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I6G75_RS09670	COG4703	Protein of unknown function (DUF1797)
I6G75_RS09685	COG2200	EAL domain
I6G75_RS09690	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS09695	COG1408	metallophosphoesterase
I6G75_RS09705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G75_RS09740	COG2814	Major facilitator Superfamily
I6G75_RS09760	COG3209	COG3209 Rhs family protein
I6G75_RS09770	COG2205	protein histidine kinase activity
I6G75_RS09780	COG0436	Aminotransferase
I6G75_RS09785	COG1609	Transcriptional regulator
I6G75_RS09790	COG3833	ABC-type maltose transport systems, permease component
I6G75_RS09795	COG1175	transmembrane transport
I6G75_RS09800	COG2182	Extracellular solute-binding protein
I6G75_RS09810	COG0366	Alpha amylase catalytic
I6G75_RS09815	COG3842	ATPase activity
I6G75_RS09860	COG0183	Belongs to the thiolase family
I6G75_RS09890	COG1695	Transcriptional regulator
I6G75_RS09895	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS09915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G75_RS09920	COG0436	Aminotransferase
I6G75_RS09955	COG2084	Dehydrogenase
I6G75_RS09960	COG2199	diguanylate cyclase activity
I6G75_RS09965	COG0778	Nitroreductase
I6G75_RS09990	COG1263	PTS System
I6G75_RS09990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G75_RS09990	COG2190	(PTS) system
I6G75_RS09995	COG3711	transcriptional antiterminator
I6G75_RS10005	COG2188	Transcriptional regulator
I6G75_RS10015	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G75_RS10040	COG1547	Domain of unknown function (DUF309)
I6G75_RS10045	COG0456	acetyltransferase
I6G75_RS10050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G75_RS10055	COG4086	secreted protein
I6G75_RS10060	COG0561	phosphatase activity
I6G75_RS10065	COG0697	spore germination
I6G75_RS10080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G75_RS10105	COG0733	neurotransmitter:sodium symporter activity
I6G75_RS10125	COG1686	Belongs to the peptidase S11 family
I6G75_RS10130	COG1725	Transcriptional regulator
I6G75_RS10135	COG1131	(ABC) transporter
I6G75_RS10150	COG1846	Transcriptional regulator
I6G75_RS10165	COG0598	Magnesium transport protein CorA
I6G75_RS10190	COG4974	Belongs to the 'phage' integrase family
I6G75_RS10200	COG0735	belongs to the Fur family
I6G75_RS10205	COG1300	Membrane
I6G75_RS10225	COG0667	Aldo Keto reductase
I6G75_RS10230	COG0656	L-ascorbic acid biosynthetic process
I6G75_RS10235	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G75_RS10235	COG0456	acetyltransferase
I6G75_RS10245	COG1525	nuclease
I6G75_RS10245	COG0737	Belongs to the 5'-nucleotidase family
I6G75_RS10245	COG4085	toxin activity
I6G75_RS10255	COG0596	Alpha beta hydrolase
I6G75_RS10260	COG2056	Na+-H+ antiporter family
I6G75_RS10265	COG1609	Transcriptional regulator
I6G75_RS10270	COG0456	acetyltransferase
I6G75_RS10275	COG1073	alpha beta
I6G75_RS10290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G75_RS10290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G75_RS10295	COG0307	riboflavin synthase, alpha
I6G75_RS10320	COG4106	trans-aconitate 2-methyltransferase activity
I6G75_RS10325	COG2226	methyltransferase
I6G75_RS10325	COG1073	alpha beta
I6G75_RS10340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G75_RS10350	COG1757	Na H antiporter
I6G75_RS10355	COG0737	Belongs to the 5'-nucleotidase family
I6G75_RS10365	COG1522	sequence-specific DNA binding
I6G75_RS10385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G75_RS10395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6G75_RS10410	COG0300	oxidoreductase activity
I6G75_RS10415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS10420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G75_RS10425	COG1760	l-serine dehydratase
I6G75_RS10430	COG1760	l-serine dehydratase
I6G75_RS10450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G75_RS10460	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G75_RS10465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G75_RS10480	COG1376	ErfK ybiS ycfS ynhG family protein
I6G75_RS10485	COG4129	membrane
I6G75_RS10490	COG1126	abc transporter atp-binding protein
I6G75_RS10495	COG0765	amino acid transport
I6G75_RS10500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G75_RS10515	COG2816	NAD+ diphosphatase activity
I6G75_RS10520	COG0772	Belongs to the SEDS family
I6G75_RS10525	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G75_RS10530	COG0022	dehydrogenase e1 component
I6G75_RS10535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G75_RS10540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G75_RS10555	COG0280	phosphate acetyltransferase
I6G75_RS10560	COG3290	protein histidine kinase activity
I6G75_RS10560	COG3829	transcription factor binding
I6G75_RS10570	COG0584	glycerophosphoryl diester phosphodiesterase
I6G75_RS10575	COG3093	addiction module antidote protein HigA
I6G75_RS10585	COG0745	RESPONSE REGULATOR receiver
I6G75_RS10590	COG0750	zinc metalloprotease
I6G75_RS10595	COG0497	DNA recombination
I6G75_RS10605	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6G75_RS10615	COG0142	geranyltranstransferase activity
I6G75_RS10640	COG1302	Protein conserved in bacteria
I6G75_RS10645	COG0439	Biotin carboxylase
I6G75_RS10650	COG0511	ligase activity, forming carbon-carbon bonds
I6G75_RS10695	COG3854	ATPases associated with a variety of cellular activities
I6G75_RS10720	COG0006	proline dipeptidase activity
I6G75_RS10735	COG3872	metal-dependent enzyme
I6G75_RS10745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G75_RS10760	COG1695	Transcriptional regulator
I6G75_RS10775	COG0095	Lipoate-protein ligase
I6G75_RS10780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G75_RS10785	COG1609	Transcriptional regulator
I6G75_RS10795	COG2076	Multidrug Resistance protein
I6G75_RS10800	COG2076	Multidrug Resistance protein
I6G75_RS10835	COG1131	(ABC) transporter
I6G75_RS10840	COG1725	Transcriptional regulator
I6G75_RS10870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G75_RS10925	COG4970	Tfp pilus assembly protein FimT
I6G75_RS10935	COG1459	type II secretion system
I6G75_RS10940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G75_RS10990	COG0646	methionine synthase
I6G75_RS10990	COG1410	methionine synthase
I6G75_RS10995	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G75_RS10995	COG0646	methionine synthase
I6G75_RS11000	COG0626	cystathionine gamma-synthase activity
I6G75_RS11005	COG0626	cystathionine gamma-synthase activity
I6G75_RS11025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS11035	COG1940	carbohydrate kinase activity
I6G75_RS11040	COG4483	Protein conserved in bacteria
I6G75_RS11045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G75_RS11050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G75_RS11055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6G75_RS11060	COG0704	Plays a role in the regulation of phosphate uptake
I6G75_RS11070	COG0581	inorganic phosphate transmembrane transporter activity
I6G75_RS11075	COG0573	inorganic phosphate transmembrane transporter activity
I6G75_RS11080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G75_RS11085	COG0768	penicillin binding
I6G75_RS11090	COG0477	Major facilitator Superfamily
I6G75_RS11095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G75_RS11120	COG0735	belongs to the Fur family
I6G75_RS11125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G75_RS11130	COG1121	(ABC) transporter
I6G75_RS11135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G75_RS11165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G75_RS11170	COG2384	SAM-dependent methyltransferase
I6G75_RS11175	COG2010	Cytochrome c
I6G75_RS11180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G75_RS11185	COG0358	DNA primase activity
I6G75_RS11195	COG0517	IMP dehydrogenase activity
I6G75_RS11210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G75_RS11215	COG0295	cytidine deaminase activity
I6G75_RS11220	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G75_RS11230	COG1480	7TM receptor with intracellular HD hydrolase
I6G75_RS11235	COG1702	phosphate starvation-inducible protein PhoH
I6G75_RS11250	COG1610	YqeY-like protein
I6G75_RS11255	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G75_RS11260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G75_RS11265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G75_RS11295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G75_RS11300	COG1733	regulation of RNA biosynthetic process
I6G75_RS11325	COG1466	dna polymerase III delta subunit
I6G75_RS11335	COG0658	competence protein
I6G75_RS11335	COG2333	competence protein COMEC
I6G75_RS11340	COG2131	deaminase
I6G75_RS11345	COG1596	polysaccharide export
I6G75_RS11345	COG1555	photosystem II stabilization
I6G75_RS11350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G75_RS11355	COG2226	methyltransferase
I6G75_RS11360	COG0799	negative regulation of ribosome biogenesis
I6G75_RS11365	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6G75_RS11375	COG1534	Rna-binding protein
I6G75_RS11385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G75_RS11390	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6G75_RS11415	COG1595	DNA-templated transcription, initiation
I6G75_RS11425	COG0778	Nitroreductase
I6G75_RS11430	COG2357	RelA SpoT domain protein
I6G75_RS11440	COG1785	Belongs to the alkaline phosphatase family
I6G75_RS11450	COG2267	carboxylic ester hydrolase activity
I6G75_RS11485	COG1404	Belongs to the peptidase S8 family
I6G75_RS11490	COG3186	Phenylalanine-4-hydroxylase
I6G75_RS11500	COG2514	catechol 2,3-dioxygenase activity
I6G75_RS11505	COG2259	Doxx family
I6G75_RS11545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G75_RS11555	COG1012	belongs to the aldehyde dehydrogenase family
I6G75_RS11555	COG1454	alcohol dehydrogenase
I6G75_RS11560	COG0626	cystathionine gamma-synthase activity
I6G75_RS11565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G75_RS11590	COG0768	penicillin binding
I6G75_RS11605	COG0826	peptidase U32
I6G75_RS11610	COG0826	peptidase U32
I6G75_RS11615	COG4122	O-methyltransferase activity
I6G75_RS11620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G75_RS11650	COG0628	permease
I6G75_RS11670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G75_RS11685	COG1104	cysteine desulfurase activity
I6G75_RS11690	COG1959	2 iron, 2 sulfur cluster binding
I6G75_RS11695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G75_RS11705	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G75_RS11730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G75_RS11740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G75_RS11740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6G75_RS11745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G75_RS11750	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G75_RS11750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G75_RS11760	COG2244	polysaccharide biosynthetic process
I6G75_RS11765	COG2323	membrane
I6G75_RS11775	COG1862	Preprotein translocase
I6G75_RS11805	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6G75_RS11815	COG0697	spore germination
I6G75_RS11820	COG0697	spore germination
I6G75_RS11825	COG0640	Transcriptional regulator
I6G75_RS11850	COG0157	Belongs to the NadC ModD family
I6G75_RS11860	COG1104	cysteine desulfurase activity
I6G75_RS11865	COG1827	regulation of RNA biosynthetic process
I6G75_RS11870	COG2258	MOSC domain
I6G75_RS11875	COG0077	Prephenate dehydratase
I6G75_RS11880	COG0577	efflux transmembrane transporter activity
I6G75_RS11885	COG0577	efflux transmembrane transporter activity
I6G75_RS11890	COG1136	(ABC) transporter
I6G75_RS11895	COG5002	protein histidine kinase activity
I6G75_RS11900	COG0745	RESPONSE REGULATOR receiver
I6G75_RS11910	COG3290	protein histidine kinase activity
I6G75_RS11920	COG2868	ribosomal protein
I6G75_RS11930	COG1530	ribonuclease E activity
I6G75_RS11935	COG1994	Peptidase M50
I6G75_RS11940	COG0739	heme binding
I6G75_RS11945	COG2894	cell division
I6G75_RS11965	COG1077	Cell shape determining protein MreB Mrl
I6G75_RS11985	COG0285	dihydrofolate synthase activity
I6G75_RS12000	COG1388	LysM domain
I6G75_RS12010	COG0113	porphobilinogen synthase activity
I6G75_RS12015	COG1587	Uroporphyrinogen-III synthase
I6G75_RS12025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G75_RS12035	COG1846	Transcriptional regulator
I6G75_RS12040	COG1764	response to oxidative stress
I6G75_RS12055	COG0470	DNA polymerase III
I6G75_RS12055	COG1067	ATP-dependent peptidase activity
I6G75_RS12100	COG0622	Phosphoesterase
I6G75_RS12115	COG5401	PFAM Sporulation and spore germination
I6G75_RS12135	COG1309	transcriptional regulator
I6G75_RS12150	COG2197	response regulator
I6G75_RS12155	COG2233	PERMEase
I6G75_RS12160	COG0402	S-adenosylhomocysteine deaminase activity
I6G75_RS12165	COG1983	PspC domain protein
I6G75_RS12170	COG1396	sequence-specific DNA binding
I6G75_RS12175	COG0697	spore germination
I6G75_RS12190	COG1959	2 iron, 2 sulfur cluster binding
I6G75_RS12195	COG1668	transmembrane transport
I6G75_RS12200	COG4152	abc transporter atp-binding protein
I6G75_RS12205	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6G75_RS12215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G75_RS12220	COG1876	peptidase activity
I6G75_RS12225	COG0824	Thioesterase
I6G75_RS12230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G75_RS12235	COG1053	succinate dehydrogenase
I6G75_RS12240	COG2009	succinate dehydrogenase
I6G75_RS12245	COG1719	4-vinyl reductase, 4VR
I6G75_RS12255	COG3118	belongs to the thioredoxin family
I6G75_RS12260	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6G75_RS12265	COG2086	electron transfer activity
I6G75_RS12270	COG1024	Enoyl-CoA hydratase
I6G75_RS12275	COG1309	transcriptional regulator
I6G75_RS12280	COG0318	PFAM AMP-dependent synthetase and ligase
I6G75_RS12300	COG2318	DinB family
I6G75_RS12325	COG1131	(ABC) transporter
I6G75_RS12330	COG2205	protein histidine kinase activity
I6G75_RS12335	COG0745	RESPONSE REGULATOR receiver
I6G75_RS12345	COG4895	conserved protein (DUF2196)
I6G75_RS12350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G75_RS12365	COG4509	Sortase family
I6G75_RS12370	COG1120	ATPase activity
I6G75_RS12385	COG5386	Cell surface protein
I6G75_RS12390	COG5386	Cell surface protein
I6G75_RS12395	COG1114	Component of the transport system for branched-chain amino acids
I6G75_RS12400	COG1187	pseudouridine synthase activity
I6G75_RS12410	COG1796	DNA polymerase
I6G75_RS12410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G75_RS12415	COG1286	toxin biosynthetic process
I6G75_RS12460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G75_RS12470	COG1418	mRNA catabolic process
I6G75_RS12505	COG2814	Major facilitator Superfamily
I6G75_RS12510	COG1566	PFAM secretion protein HlyD family protein
I6G75_RS12515	COG1309	transcriptional regulator
I6G75_RS12520	COG1363	Peptidase, m42
I6G75_RS12545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G75_RS12555	COG1484	DNA-dependent DNA replication
I6G75_RS12560	COG3611	Membrane attachment protein
I6G75_RS12570	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6G75_RS12575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G75_RS12580	COG0237	dephospho-CoA kinase activity
I6G75_RS12585	COG1971	Probably functions as a manganese efflux pump
I6G75_RS12595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G75_RS12595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G75_RS12600	COG5002	protein histidine kinase activity
I6G75_RS12605	COG0745	RESPONSE REGULATOR receiver
I6G75_RS12625	COG0538	isocitrate dehydrogenase activity
I6G75_RS12630	COG0372	Belongs to the citrate synthase family
I6G75_RS12640	COG0628	permease
I6G75_RS12645	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6G75_RS12670	COG1725	Transcriptional regulator
I6G75_RS12675	COG0281	malic enzyme
I6G75_RS12680	COG0587	DNA-directed DNA polymerase activity
I6G75_RS12695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6G75_RS12715	COG4109	DRTGG domain
I6G75_RS12730	COG0006	proline dipeptidase activity
I6G75_RS12785	COG1476	TRANSCRIPTIONal
I6G75_RS12800	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS12805	COG0589	response to stress
I6G75_RS12845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G75_RS12860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G75_RS12865	COG0827	DNA restriction-modification system
I6G75_RS12870	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G75_RS12875	COG3874	Sporulation protein YtfJ
I6G75_RS12890	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6G75_RS12900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G75_RS12915	COG1104	cysteine desulfurase activity
I6G75_RS12925	COG0583	DNA-binding transcription factor activity
I6G75_RS12930	COG0697	spore germination
I6G75_RS12935	COG1309	transcriptional regulator
I6G75_RS12940	COG1956	GAF domain-containing protein
I6G75_RS13000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G75_RS13005	COG0454	-acetyltransferase
I6G75_RS13010	COG0517	IMP dehydrogenase activity
I6G75_RS13015	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6G75_RS13030	COG0745	RESPONSE REGULATOR receiver
I6G75_RS13040	COG0666	response to abiotic stimulus
I6G75_RS13075	COG1609	Transcriptional regulator
I6G75_RS13080	COG4851	CamS sex pheromone cAM373 precursor
I6G75_RS13085	COG3118	belongs to the thioredoxin family
I6G75_RS13095	COG2309	aminopeptidase activity
I6G75_RS13115	COG0577	efflux transmembrane transporter activity
I6G75_RS13120	COG1136	(ABC) transporter
I6G75_RS13135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G75_RS13140	COG1695	Transcriptional regulator
I6G75_RS13160	COG1674	ftsk spoiiie
I6G75_RS13170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G75_RS13180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G75_RS13185	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6G75_RS13190	COG1363	Peptidase, m42
I6G75_RS13200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS13215	COG0510	thiamine kinase activity
I6G75_RS13220	COG1523	belongs to the glycosyl hydrolase 13 family
I6G75_RS13230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G75_RS13235	COG1349	DNA-binding transcription factor activity
I6G75_RS13240	COG1187	pseudouridine synthase activity
I6G75_RS13245	COG2244	polysaccharide biosynthetic process
I6G75_RS13250	COG2081	HI0933 family
I6G75_RS13255	COG2814	Major facilitator Superfamily
I6G75_RS13265	COG3832	glyoxalase III activity
I6G75_RS13285	COG1329	Transcriptional regulator
I6G75_RS13310	COG0314	molybdopterin synthase activity
I6G75_RS13315	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6G75_RS13320	COG0303	'Molybdopterin
I6G75_RS13330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G75_RS13335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G75_RS13355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G75_RS13365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G75_RS13405	COG2814	Major facilitator Superfamily
I6G75_RS13410	COG0475	glutathione-regulated potassium exporter activity
I6G75_RS13415	COG0490	domain, Protein
I6G75_RS13420	COG0582	viral genome integration into host DNA
I6G75_RS13430	COG1136	(ABC) transporter
I6G75_RS13450	COG1242	4 iron, 4 sulfur cluster binding
I6G75_RS13455	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6G75_RS13470	COG1794	racemase activity, acting on amino acids and derivatives
I6G75_RS13490	COG2267	carboxylic ester hydrolase activity
I6G75_RS13495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G75_RS13500	COG0671	phosphoesterase, PA-phosphatase related
I6G75_RS13505	COG0438	transferase activity, transferring glycosyl groups
I6G75_RS13515	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G75_RS13580	COG0546	phosphoglycolate phosphatase activity
I6G75_RS13585	COG1349	DNA-binding transcription factor activity
I6G75_RS13595	COG5002	protein histidine kinase activity
I6G75_RS13600	COG4191	Histidine kinase
I6G75_RS13605	COG2267	carboxylic ester hydrolase activity
I6G75_RS13610	COG1368	sulfuric ester hydrolase activity
I6G75_RS13625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G75_RS13630	COG1116	anion transmembrane transporter activity
I6G75_RS13635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G75_RS13650	COG0546	phosphoglycolate phosphatase activity
I6G75_RS13660	COG0494	nUDIX hydrolase
I6G75_RS13690	COG0288	reversible hydration of carbon dioxide
I6G75_RS13695	COG1271	oxidase subunit
I6G75_RS13700	COG1294	oxidase, subunit
I6G75_RS13720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G75_RS13745	COG1842	Phage shock protein A
I6G75_RS13805	COG3859	Proton-coupled thiamine transporter YuaJ
I6G75_RS13810	COG5002	protein histidine kinase activity
I6G75_RS13815	COG0745	RESPONSE REGULATOR receiver
I6G75_RS13840	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G75_RS13845	COG1597	lipid kinase activity
I6G75_RS13875	COG0586	Pfam SNARE associated Golgi protein
I6G75_RS13885	COG4977	sequence-specific DNA binding
I6G75_RS13895	COG0577	efflux transmembrane transporter activity
I6G75_RS13900	COG1136	(ABC) transporter
I6G75_RS13905	COG3708	Transcriptional regulator
I6G75_RS13905	COG2207	Transcriptional regulator
I6G75_RS13910	COG0745	RESPONSE REGULATOR receiver
I6G75_RS13915	COG2205	protein histidine kinase activity
I6G75_RS13920	COG0577	efflux transmembrane transporter activity
I6G75_RS13925	COG0577	efflux transmembrane transporter activity
I6G75_RS13930	COG1136	(ABC) transporter
I6G75_RS13935	COG0577	efflux transmembrane transporter activity
I6G75_RS13950	COG2188	Transcriptional regulator
I6G75_RS13970	COG3964	amidohydrolase
I6G75_RS13990	COG4948	Mandelate Racemase Muconate Lactonizing
I6G75_RS14000	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G75_RS14005	COG0596	Alpha beta hydrolase
I6G75_RS14015	COG1169	isochorismate synthase
I6G75_RS14020	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G75_RS14025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G75_RS14045	COG0058	SHG alpha-glucan phosphorylase activity
I6G75_RS14055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G75_RS14075	COG1404	Belongs to the peptidase S8 family
I6G75_RS14175	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G75_RS14210	COG1285	pathogenesis
I6G75_RS14215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G75_RS14230	COG2155	Conserved Protein
I6G75_RS14235	COG1098	S1 RNA binding domain
I6G75_RS14240	COG0436	Aminotransferase
I6G75_RS14245	COG1522	sequence-specific DNA binding
I6G75_RS14250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G75_RS14255	COG2267	carboxylic ester hydrolase activity
I6G75_RS14285	COG5018	Exonuclease
I6G75_RS14290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G75_RS14310	COG2050	protein possibly involved in aromatic compounds catabolism
I6G75_RS14320	COG1268	BioY protein
I6G75_RS14325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G75_RS14330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G75_RS14345	COG3584	3D domain protein
I6G75_RS14360	COG1252	NADH dehydrogenase
I6G75_RS14390	COG1683	Conserved Protein
I6G75_RS14400	COG0316	Belongs to the HesB IscA family
I6G75_RS14415	COG1252	NADH dehydrogenase
I6G75_RS14430	COG0390	transport system, permease component
I6G75_RS14435	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G75_RS14455	COG4837	Protein of unknown function (DUF1462)
I6G75_RS14460	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6G75_RS14470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G75_RS14475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G75_RS14490	COG1136	(ABC) transporter
I6G75_RS14490	COG0577	efflux transmembrane transporter activity
I6G75_RS14495	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G75_RS14500	COG0647	UMP catabolic process
I6G75_RS14510	COG2445	Protein of unknown function DUF86
I6G75_RS14515	COG1494	fructose-1,6-bisphosphatase
I6G75_RS14530	COG4470	Protein conserved in bacteria
I6G75_RS14540	COG0789	Transcriptional regulator
I6G75_RS14545	COG4377	Putative membrane peptidase family (DUF2324)
I6G75_RS14570	COG0739	heme binding
I6G75_RS14580	COG3377	Domain of unknown function (DUF1805)
I6G75_RS14585	COG0737	Belongs to the 5'-nucleotidase family
I6G75_RS14590	COG1695	Transcriptional regulator
I6G75_RS14600	COG0719	Fe-S assembly protein
I6G75_RS14605	COG0822	iron-sulfur transferase activity
I6G75_RS14610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G75_RS14615	COG0719	Fe-S assembly protein
I6G75_RS14620	COG0396	ATPase activity
I6G75_RS14625	COG1464	Belongs to the NlpA lipoprotein family
I6G75_RS14630	COG1464	Belongs to the NlpA lipoprotein family
I6G75_RS14635	COG2011	ABC-type metal ion transport system permease component
I6G75_RS14650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G75_RS14655	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6G75_RS14665	COG1393	Belongs to the ArsC family
I6G75_RS14710	COG0039	L-malate dehydrogenase activity
I6G75_RS14735	COG1396	sequence-specific DNA binding
I6G75_RS14740	COG1309	transcriptional regulator
I6G75_RS14745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS14755	COG4555	ABC transporter
I6G75_RS14780	COG1960	acyl-CoA dehydrogenase activity
I6G75_RS14785	COG0183	Belongs to the thiolase family
I6G75_RS14790	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G75_RS14790	COG1024	Enoyl-CoA hydratase
I6G75_RS14800	COG1686	Belongs to the peptidase S11 family
I6G75_RS14815	COG0011	TIGRFAM Protein of
I6G75_RS14820	COG0840	transmembrane signaling receptor activity
I6G75_RS14840	COG2814	Major facilitator Superfamily
I6G75_RS14845	COG0531	amino acid
I6G75_RS14860	COG0706	membrane insertase activity
I6G75_RS14870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G75_RS14905	COG0586	Pfam SNARE associated Golgi protein
I6G75_RS14915	COG1376	ErfK ybiS ycfS ynhG family protein
I6G75_RS14920	COG0745	RESPONSE REGULATOR receiver
I6G75_RS14925	COG5002	protein histidine kinase activity
I6G75_RS14945	COG0840	transmembrane signaling receptor activity
I6G75_RS14950	COG0840	transmembrane signaling receptor activity
I6G75_RS14955	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G75_RS14960	COG3227	Zinc metalloprotease (Elastase)
I6G75_RS14965	COG1741	Belongs to the pirin family
I6G75_RS14980	COG0475	glutathione-regulated potassium exporter activity
I6G75_RS14985	COG0490	domain, Protein
I6G75_RS14990	COG1115	amino acid carrier protein
I6G75_RS14995	COG0783	Belongs to the Dps family
I6G75_RS15010	COG1611	Belongs to the LOG family
I6G75_RS15030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G75_RS15035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G75_RS15040	COG1115	amino acid carrier protein
I6G75_RS15045	COG1115	amino acid carrier protein
I6G75_RS15050	COG2910	NAD(P)H-binding
I6G75_RS15065	COG0656	L-ascorbic acid biosynthetic process
I6G75_RS15070	COG2814	Major facilitator Superfamily
I6G75_RS15075	COG1733	regulation of RNA biosynthetic process
I6G75_RS15085	COG1252	NADH dehydrogenase
I6G75_RS15090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G75_RS15105	COG0840	transmembrane signaling receptor activity
I6G75_RS15105	COG3290	protein histidine kinase activity
I6G75_RS15115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G75_RS15140	COG0488	(ABC) transporter
I6G75_RS15145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G75_RS15195	COG0557	exoribonuclease II activity
I6G75_RS15200	COG1647	Serine aminopeptidase, S33
I6G75_RS15205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G75_RS15210	COG1346	cytolysis
I6G75_RS15245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G75_RS15260	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G75_RS15355	COG4974	Belongs to the 'phage' integrase family
I6G75_RS15375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G75_RS15390	COG2323	membrane
I6G75_RS15400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G75_RS15410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6G75_RS15420	COG1051	belongs to the nudix hydrolase family
I6G75_RS15430	COG0492	ferredoxin-NADP+ reductase activity
I6G75_RS15435	COG0457	Tetratricopeptide repeat
I6G75_RS15440	COG0110	maltose O-acetyltransferase activity
I6G75_RS15460	COG1950	PFAM Membrane protein of
I6G75_RS15470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G75_RS15475	COG0556	nucleotide-excision repair
I6G75_RS15490	COG0789	Transcriptional regulator
I6G75_RS15515	COG2855	membrane
I6G75_RS15520	COG0583	DNA-binding transcription factor activity
I6G75_RS15530	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6G75_RS15535	COG0488	(ABC) transporter
I6G75_RS15545	COG1132	(ABC) transporter
I6G75_RS15550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G75_RS15555	COG0793	Belongs to the peptidase S41A family
I6G75_RS15555	COG3409	Peptidoglycan-binding domain 1 protein
I6G75_RS15560	COG2177	Part of the ABC transporter FtsEX involved in
I6G75_RS15565	COG2884	Cell division ATP-binding protein ftsE
I6G75_RS15585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G75_RS15590	COG1278	Cold shock
I6G75_RS15595	COG1040	competence protein
I6G75_RS15600	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6G75_RS15605	COG0791	NLP P60 protein
I6G75_RS15605	COG1388	LysM domain
I6G75_RS15610	COG1733	regulation of RNA biosynthetic process
I6G75_RS15615	COG1307	EDD domain protein, DegV family
I6G75_RS15620	COG1739	Uncharacterized protein family UPF0029
I6G75_RS15625	COG1316	TRANSCRIPTIONal
I6G75_RS15630	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G75_RS15635	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6G75_RS15640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G75_RS15650	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6G75_RS15650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6G75_RS15670	COG1486	melibiose metabolic process
I6G75_RS15675	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G75_RS15680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G75_RS15690	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6G75_RS15710	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G75_RS15720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G75_RS15725	COG1301	dicarboxylic acid transport
I6G75_RS15735	COG0346	lactoylglutathione lyase activity
I6G75_RS15755	COG1511	domain protein
I6G75_RS15760	COG0583	DNA-binding transcription factor activity
I6G75_RS15765	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6G75_RS15775	COG1271	oxidase subunit
I6G75_RS15780	COG1294	oxidase, subunit
I6G75_RS15785	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G75_RS15795	COG1620	l-lactate permease
I6G75_RS15810	COG2389	metal-binding protein
I6G75_RS15820	COG1368	sulfuric ester hydrolase activity
I6G75_RS15830	COG1388	LysM domain
I6G75_RS15830	COG0791	NLP P60 protein
I6G75_RS15835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G75_RS15845	COG1215	transferase activity, transferring glycosyl groups
I6G75_RS15850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G75_RS15855	COG1388	LysM domain
I6G75_RS15855	COG3584	3D domain protein
I6G75_RS15880	COG4715	Zinc finger, swim domain protein
I6G75_RS15885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G75_RS15930	COG0577	efflux transmembrane transporter activity
I6G75_RS15935	COG1136	(ABC) transporter
I6G75_RS15975	COG0745	RESPONSE REGULATOR receiver
I6G75_RS15980	COG1482	cell wall glycoprotein biosynthetic process
I6G75_RS15985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G75_RS15985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G75_RS15985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G75_RS15990	COG3711	transcriptional antiterminator
I6G75_RS15990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G75_RS15995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G75_RS16005	COG1316	TRANSCRIPTIONal
I6G75_RS16010	COG1482	cell wall glycoprotein biosynthetic process
I6G75_RS16015	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6G75_RS16015	COG0662	Cupin 2, conserved barrel domain protein
I6G75_RS16020	COG0438	transferase activity, transferring glycosyl groups
I6G75_RS16030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6G75_RS16045	COG2244	polysaccharide biosynthetic process
I6G75_RS16050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G75_RS16055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G75_RS16060	COG4464	protein tyrosine phosphatase activity
I6G75_RS16065	COG0489	protein tyrosine kinase activity
I6G75_RS16070	COG3944	biosynthesis protein
I6G75_RS16075	COG0489	protein tyrosine kinase activity
I6G75_RS16090	COG1609	Transcriptional regulator
I6G75_RS16100	COG0739	heme binding
I6G75_RS16115	COG3279	Response regulator of the LytR AlgR family
I6G75_RS16120	COG2385	sporulation resulting in formation of a cellular spore
I6G75_RS16135	COG4836	Membrane
I6G75_RS16140	COG1007	ATP synthesis coupled electron transport
I6G75_RS16145	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G75_RS16150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G75_RS16160	COG0839	Belongs to the complex I subunit 6 family
I6G75_RS16175	COG0649	NAD binding
I6G75_RS16180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G75_RS16195	COG5001	Diguanylate cyclase
I6G75_RS16195	COG3300	MHYT domain
I6G75_RS16245	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G75_RS16290	COG0698	ribose 5-phosphate isomerase
I6G75_RS16300	COG2190	(PTS) system
I6G75_RS16305	COG2259	Doxx family
I6G75_RS16310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G75_RS16330	COG0009	L-threonylcarbamoyladenylate synthase
I6G75_RS16345	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G75_RS16365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G75_RS16370	COG1494	fructose-1,6-bisphosphatase
I6G75_RS16390	COG4821	SIS domain
I6G75_RS16410	COG1960	acyl-CoA dehydrogenase activity
I6G75_RS16415	COG1960	acyl-CoA dehydrogenase activity
I6G75_RS16420	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G75_RS16425	COG0183	Belongs to the thiolase family
I6G75_RS16430	COG2181	nitrate reductase activity
I6G75_RS16430	COG0247	lactate metabolic process
I6G75_RS16435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G75_RS16445	COG3300	MHYT domain
I6G75_RS16445	COG5001	Diguanylate cyclase
I6G75_RS16465	COG2197	response regulator
I6G75_RS16470	COG4585	Histidine kinase
I6G75_RS16475	COG0842	Transport permease protein
I6G75_RS16480	COG1131	(ABC) transporter
I6G75_RS16485	COG0024	Methionine aminopeptidase
I6G75_RS16495	COG2234	aminopeptidase activity
I6G75_RS16515	COG1595	DNA-templated transcription, initiation
I6G75_RS16525	COG4506	Protein conserved in bacteria
I6G75_RS16530	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G75_RS16545	COG0010	Belongs to the arginase family
I6G75_RS16555	COG2814	Major facilitator Superfamily
I6G75_RS16560	COG0789	Transcriptional regulator
I6G75_RS16565	COG0584	glycerophosphoryl diester phosphodiesterase
I6G75_RS16570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G75_RS16580	COG1994	Peptidase M50
I6G75_RS16590	COG1078	dGTPase activity
I6G75_RS16595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G75_RS16600	COG1120	ATPase activity
I6G75_RS16605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G75_RS16610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G75_RS16630	COG0095	Lipoate-protein ligase
I6G75_RS16635	COG0280	phosphate acetyltransferase
I6G75_RS16650	COG3773	Cell wall hydrolase
I6G75_RS16660	COG2363	Small membrane protein
I6G75_RS16670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G75_RS16675	COG2233	PERMEase
I6G75_RS16680	COG0561	phosphatase activity
I6G75_RS16685	COG2814	Major facilitator Superfamily
I6G75_RS16695	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G75_RS16700	COG1131	(ABC) transporter
I6G75_RS16705	COG2755	lipolytic protein G-D-S-L family
I6G75_RS16710	COG1609	Transcriptional regulator
I6G75_RS16720	COG0460	homoserine dehydrogenase
I6G75_RS16730	COG2873	o-acetylhomoserine
I6G75_RS16735	COG1011	Hydrolase
I6G75_RS16740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G75_RS16750	COG2197	response regulator
I6G75_RS16755	COG2203	Gaf domain
I6G75_RS16755	COG4585	Histidine kinase
I6G75_RS16760	COG0351	phosphomethylpyrimidine kinase
I6G75_RS16765	COG3706	GGDEF domain
I6G75_RS16770	COG2879	small protein
I6G75_RS16775	COG1966	Carbon starvation protein
I6G75_RS16780	COG3279	Response regulator of the LytR AlgR family
I6G75_RS16785	COG0477	Major facilitator Superfamily
I6G75_RS16810	COG0840	transmembrane signaling receptor activity
I6G75_RS16820	COG1607	acyl-coa hydrolase
I6G75_RS16835	COG0488	(ABC) transporter
I6G75_RS16855	COG0463	Glycosyl transferase, family 2
I6G75_RS16860	COG1309	transcriptional regulator
I6G75_RS16865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G75_RS16870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G75_RS16870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G75_RS16875	COG0628	permease
I6G75_RS16890	COG3279	Response regulator of the LytR AlgR family
I6G75_RS16895	COG3275	phosphorelay sensor kinase activity
I6G75_RS16900	COG2814	Major facilitator Superfamily
I6G75_RS16905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G75_RS16910	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I6G75_RS16915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G75_RS16935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G75_RS16940	COG1272	protein, Hemolysin III
I6G75_RS16965	COG1164	Oligoendopeptidase f
I6G75_RS16985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G75_RS16990	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G75_RS16995	COG4853	Protein conserved in bacteria
I6G75_RS17000	COG4863	YycH protein
I6G75_RS17005	COG5002	protein histidine kinase activity
I6G75_RS17010	COG0745	RESPONSE REGULATOR receiver
I6G75_RS17040	COG0305	Participates in initiation and elongation during chromosome replication
I6G75_RS17050	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6G75_RS17055	COG4241	membrane
I6G75_RS17065	COG0629	single-stranded DNA binding
I6G75_RS17075	COG0012	GTP binding
I6G75_RS17080	COG4481	Protein conserved in bacteria
I6G75_RS17085	COG0668	transmembrane transport
I6G75_RS17095	COG1475	DNA binding
I6G75_RS17100	COG1192	Involved in chromosome partitioning
I6G75_RS17125	COG1847	R3H domain protein
I6G75_RS17130	COG0706	membrane insertase activity
I6G75_RS17140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G75_RS17150	COG0592	DNA-directed DNA polymerase activity
I6G75_RS17155	COG2501	S4 domain
I6G75_RS17165	COG0187	DNA topoisomerase II activity
I6G75_RS17170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G75_RS17205	COG0516	GMP reductase activity
I6G75_RS17205	COG0517	IMP dehydrogenase activity
I6G75_RS17210	COG1686	Belongs to the peptidase S11 family
I6G75_RS17240	COG1428	Deoxynucleoside kinase
I6G75_RS17245	COG1428	Deoxynucleoside kinase
I6G75_RS17250	COG1335	isochorismatase
I6G75_RS17255	COG0590	tRNA wobble adenosine to inosine editing
I6G75_RS17265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G75_RS17320	COG1982	Orn Lys Arg decarboxylase major
I6G75_RS17330	COG0470	DNA polymerase III
I6G75_RS17335	COG1774	PSP1 C-terminal conserved region
I6G75_RS17345	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G75_RS17355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G75_RS17360	COG2002	toxin-antitoxin pair type II binding
I6G75_RS17365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G75_RS17365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G75_RS17370	COG0084	hydrolase, TatD family'
I6G75_RS17375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6G75_RS17390	COG4466	Protein conserved in bacteria
I6G75_RS17405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G75_RS17410	COG0251	oxidation-reduction process
I6G75_RS17440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G75_RS17445	COG2002	toxin-antitoxin pair type II binding
I6G75_RS17450	COG2244	polysaccharide biosynthetic process
I6G75_RS17455	COG3956	TIGRFAM MazG family protein
I6G75_RS17460	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G75_RS17480	COG1098	S1 RNA binding domain
I6G75_RS17495	COG2208	phosphoserine phosphatase activity
I6G75_RS17505	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G75_RS17510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G75_RS17525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G75_RS17530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G75_RS17535	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G75_RS17540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G75_RS17545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G75_RS17550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G75_RS17555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G75_RS17560	COG1396	sequence-specific DNA binding
I6G75_RS17565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G75_RS17655	COG3880	PFAM UvrB UvrC protein
I6G75_RS17665	COG0542	response to heat
I6G75_RS17670	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6G75_RS17680	COG4956	integral membrane protein (PIN domain superfamily)
I6G75_RS17700	COG1045	serine acetyltransferase
I6G75_RS17715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G75_RS17720	COG3688	RNA-binding protein containing a PIN domain
I6G75_RS17735	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G75_RS17740	COG0250	Participates in transcription elongation, termination and antitermination
I6G75_RS17745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G75_RS17765	COG2813	Specifically methylates the guanine in position
I6G75_RS17780	COG1358	cellular component organization or biogenesis
I6G75_RS17850	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G75_RS17910	COG0201	protein transport
I6G75_RS17920	COG0024	Methionine aminopeptidase
I6G75_RS17930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G75_RS17965	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6G75_RS17990	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G75_RS17995	COG0489	protein tyrosine kinase activity
I6G75_RS18005	COG2194	sulfuric ester hydrolase activity
I6G75_RS18010	COG0726	polysaccharide deacetylase
I6G75_RS18090	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6G75_RS18095	COG4856	YbbR-like protein
I6G75_RS18140	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G75_RS18145	COG0823	Involved in the tonB-independent uptake of proteins
I6G75_RS18145	COG1506	peptidase
I6G75_RS18145	COG4946	Tricorn protease homolog
I6G75_RS18175	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS18180	COG2011	ABC-type metal ion transport system permease component
I6G75_RS18185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G75_RS18190	COG1464	Belongs to the NlpA lipoprotein family
I6G75_RS18195	COG0604	alcohol dehydrogenase
I6G75_RS18205	COG0277	FAD linked oxidase domain protein
I6G75_RS18210	COG2271	Major facilitator Superfamily
I6G75_RS18220	COG2814	Major facilitator Superfamily
I6G75_RS18235	COG0601	transmembrane transport
I6G75_RS18240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G75_RS18245	COG0444	Belongs to the ABC transporter superfamily
I6G75_RS18250	COG4608	Belongs to the ABC transporter superfamily
I6G75_RS18255	COG4166	transmembrane transport
I6G75_RS18265	COG2207	Transcriptional regulator
I6G75_RS18275	COG1309	transcriptional regulator
I6G75_RS18285	COG4166	transmembrane transport
I6G75_RS18290	COG4166	transmembrane transport
I6G75_RS18295	COG0656	L-ascorbic acid biosynthetic process
I6G75_RS18315	COG4149	molybdate abc transporter
I6G75_RS18320	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G75_RS18325	COG1910	domain protein
I6G75_RS18340	COG0697	spore germination
I6G75_RS18355	COG0204	Acyl-transferase
I6G75_RS18365	COG1609	Transcriptional regulator
I6G75_RS18375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G75_RS18385	COG0084	hydrolase, TatD family'
I6G75_RS18395	COG5298	Protein conserved in bacteria
I6G75_RS18420	COG0488	(ABC) transporter
I6G75_RS18435	COG0747	negative chemotaxis
I6G75_RS18440	COG0601	transmembrane transport
I6G75_RS18445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G75_RS18450	COG0444	Belongs to the ABC transporter superfamily
I6G75_RS18455	COG4608	Belongs to the ABC transporter superfamily
I6G75_RS18460	COG0561	phosphatase activity
I6G75_RS18490	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6G75_RS18495	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G75_RS18505	COG2814	Major facilitator Superfamily
I6G75_RS18515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G75_RS18525	COG4294	response to UV
I6G75_RS18530	COG0705	Rhomboid family
I6G75_RS18530	COG0457	Tetratricopeptide repeat
I6G75_RS18540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G75_RS18545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G75_RS18550	COG0864	Transcriptional regulator
I6G75_RS18555	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6G75_RS18560	COG2183	response to ionizing radiation
I6G75_RS18655	COG0802	atpase or kinase
I6G75_RS18660	COG1214	PFAM Peptidase M22, glycoprotease
I6G75_RS18665	COG0456	acetyltransferase
I6G75_RS18675	COG0488	(ABC) transporter
I6G75_RS18690	COG1266	CAAX protease self-immunity
I6G75_RS18705	COG5444	nuclease activity
I6G75_RS18720	COG2252	PERMEase
I6G75_RS18730	COG5002	protein histidine kinase activity
I6G75_RS18755	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G75_RS18825	COG2205	protein histidine kinase activity
I6G75_RS18830	COG0745	RESPONSE REGULATOR receiver
I6G75_RS18850	COG0697	spore germination
I6G75_RS18875	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G75_RS18880	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G75_RS18885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G75_RS18895	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G75_RS18910	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G75_RS18920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G75_RS18930	COG0151	Belongs to the GarS family
I6G75_RS18955	COG0210	DNA helicase
I6G75_RS18965	COG4851	CamS sex pheromone cAM373 precursor
I6G75_RS18985	COG1335	isochorismatase
I6G75_RS18990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G75_RS18995	COG2011	ABC-type metal ion transport system permease component
I6G75_RS19000	COG1464	Belongs to the NlpA lipoprotein family
I6G75_RS19015	COG0003	Pfam Anion-transporting ATPase
I6G75_RS19020	COG1846	Transcriptional regulator
I6G75_RS19025	COG4682	membrane
I6G75_RS19045	COG1597	lipid kinase activity
I6G75_RS19050	COG0546	phosphoglycolate phosphatase activity
I6G75_RS19055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G75_RS19065	COG1012	belongs to the aldehyde dehydrogenase family
I6G75_RS19070	COG2076	Multidrug Resistance protein
I6G75_RS19075	COG2309	aminopeptidase activity
I6G75_RS19090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G75_RS19095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G75_RS19100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G75_RS19105	COG5002	protein histidine kinase activity
I6G75_RS19110	COG4807	Protein conserved in bacteria
I6G75_RS19135	COG1757	Na H antiporter
I6G75_RS19140	COG1473	amidohydrolase
I6G75_RS19155	COG0450	alkyl hydroperoxide reductase
I6G75_RS19175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G75_RS19180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G75_RS19185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G75_RS19200	COG0166	Belongs to the GPI family
I6G75_RS19250	COG3541	Predicted nucleotidyltransferase
I6G75_RS19255	COG2814	Major facilitator Superfamily
I6G75_RS19260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G75_RS19260	COG0723	plastoquinol--plastocyanin reductase activity
I6G75_RS19270	COG0765	amino acid transport
I6G75_RS19275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G75_RS19285	COG0840	transmembrane signaling receptor activity
I6G75_RS19290	COG0366	Alpha amylase catalytic
I6G75_RS19295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G75_RS19295	COG1263	PTS System
I6G75_RS19295	COG2190	(PTS) system
I6G75_RS19325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G75_RS19340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G75_RS19350	COG1116	anion transmembrane transporter activity
I6G75_RS19360	COG0488	(ABC) transporter
I6G75_RS19410	COG2270	Major facilitator Superfamily
I6G75_RS19440	COG2310	stress, protein
I6G75_RS19445	COG2310	stress, protein
I6G75_RS19450	COG2310	stress, protein
I6G75_RS19455	COG0861	Integral membrane protein TerC family
I6G75_RS19465	COG3853	Toxic anion resistance protein (TelA)
I6G75_RS19480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G75_RS19490	COG1295	ribonuclease BN
I6G75_RS19495	COG2217	Heavy metal translocating P-type atpase
I6G75_RS19500	COG0697	spore germination
I6G75_RS19520	COG0586	Pfam SNARE associated Golgi protein
I6G75_RS19535	COG3871	stress protein (general stress protein 26)
I6G75_RS19540	COG0387	Pfam Sodium calcium exchanger
I6G75_RS19550	COG0535	radical SAM domain protein
I6G75_RS19570	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6G75_RS19590	COG3829	transcription factor binding
I6G75_RS19600	COG0833	amino acid
I6G75_RS19605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G75_RS19635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G75_RS19635	COG1263	PTS System
I6G75_RS19640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G75_RS19655	COG0463	Glycosyl transferase, family 2
I6G75_RS19665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G75_RS19665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G75_RS19685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G75_RS19705	COG1228	amidohydrolase
I6G75_RS19710	COG1090	epimerase
I6G75_RS19740	COG1988	membrane-bound metal-dependent
I6G75_RS19745	COG1194	a g-specific adenine glycosylase
I6G75_RS19770	COG1132	(ABC) transporter
I6G75_RS19775	COG4129	membrane
I6G75_RS19780	COG0067	glutamate synthase
I6G75_RS19780	COG0069	glutamate synthase activity
I6G75_RS19780	COG0070	glutamate synthase
I6G75_RS19790	COG4555	ABC transporter
I6G75_RS19810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G75_RS19815	COG0735	belongs to the Fur family
I6G75_RS19930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6G75_RS19935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G75_RS19945	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G75_RS19955	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G75_RS19960	COG1716	ATPase activity
I6G75_RS19960	COG5001	Diguanylate cyclase
I6G75_RS19965	COG2766	serine protein kinase
I6G75_RS19985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G75_RS19995	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G75_RS20000	COG2268	Band 7 protein
I6G75_RS20010	COG3290	protein histidine kinase activity
I6G75_RS20015	COG4565	transcriptional regulatory protein
I6G75_RS20020	COG2851	Citrate transporter
I6G75_RS20040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G75_RS20045	COG0745	RESPONSE REGULATOR receiver
I6G75_RS20050	COG5002	protein histidine kinase activity
I6G75_RS20060	COG4990	cell redox homeostasis
I6G75_RS20070	COG3290	protein histidine kinase activity
I6G75_RS20075	COG4565	transcriptional regulatory protein
I6G75_RS20080	COG3493	citrate carrier protein
I6G75_RS20085	COG0281	malic enzyme
I6G75_RS20100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G75_RS20110	COG5002	protein histidine kinase activity
I6G75_RS20115	COG0745	RESPONSE REGULATOR receiver
I6G75_RS20120	COG0454	-acetyltransferase
I6G75_RS20120	COG0456	acetyltransferase
I6G75_RS20125	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G75_RS20130	COG3383	formate dehydrogenase (NAD+) activity
I6G75_RS20135	COG2427	Protein of unknown function (DUF1641)
I6G75_RS20150	COG0531	amino acid
I6G75_RS20155	COG0640	Transcriptional regulator
I6G75_RS20160	COG2217	Heavy metal translocating P-type atpase
I6G75_RS20165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G75_RS20180	COG3227	Zinc metalloprotease (Elastase)
I6G75_RS20200	COG2720	vancomycin resistance protein
I6G75_RS20205	COG1316	TRANSCRIPTIONal
I6G75_RS20210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G75_RS20215	COG0346	lactoylglutathione lyase activity
I6G75_RS20220	COG1253	flavin adenine dinucleotide binding
I6G75_RS20225	COG1027	Aspartate ammonia-lyase
I6G75_RS20230	COG1620	l-lactate permease
I6G75_RS20255	COG3104	oligopeptide transport
I6G75_RS20260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G75_RS20265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G75_RS20270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G75_RS20280	COG2226	methyltransferase
I6G75_RS20285	COG0156	8-amino-7-oxononanoate synthase activity
I6G75_RS20290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G75_RS20295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G75_RS20305	COG4548	von Willebrand factor, type A
I6G75_RS20310	COG0714	Associated with various cellular activities
I6G75_RS20315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G75_RS20330	COG0531	amino acid
I6G75_RS20335	COG2188	Transcriptional regulator
I6G75_RS20340	COG1263	PTS System
I6G75_RS20340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G75_RS20345	COG0366	Alpha amylase catalytic
I6G75_RS20360	COG0697	spore germination
I6G75_RS20365	COG4585	Histidine kinase
I6G75_RS20370	COG2197	response regulator
I6G75_RS20375	COG1404	Belongs to the peptidase S8 family
I6G75_RS20390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G75_RS20395	COG1115	amino acid carrier protein
I6G75_RS20400	COG1126	abc transporter atp-binding protein
I6G75_RS20405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G75_RS20410	COG0765	amino acid transport
I6G75_RS20415	COG0765	amino acid transport
I6G75_RS20420	COG0833	amino acid
I6G75_RS20445	COG2378	regulation of single-species biofilm formation
I6G75_RS20450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G75_RS20455	COG5002	protein histidine kinase activity
I6G75_RS20470	COG0659	secondary active sulfate transmembrane transporter activity
I6G75_RS20485	COG0747	negative chemotaxis
I6G75_RS20495	COG0601	transmembrane transport
I6G75_RS20500	COG4608	Belongs to the ABC transporter superfamily
I6G75_RS20510	COG2271	Major facilitator Superfamily
I6G75_RS20515	COG1846	Transcriptional regulator
I6G75_RS20520	COG0477	Major facilitator Superfamily
I6G75_RS20525	COG1609	Transcriptional regulator
I6G75_RS20530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G75_RS20545	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G75_RS20550	COG1879	ABC-type sugar transport system periplasmic component
I6G75_RS20570	COG1063	alcohol dehydrogenase
I6G75_RS20585	COG3568	Endonuclease Exonuclease Phosphatase
I6G75_RS20615	COG0840	transmembrane signaling receptor activity
I6G75_RS20620	COG1388	LysM domain
I6G75_RS20620	COG3584	3D domain protein
I6G75_RS20625	COG1476	TRANSCRIPTIONal
I6G75_RS20640	COG3104	oligopeptide transport
I6G75_RS20645	COG1114	Component of the transport system for branched-chain amino acids
I6G75_RS20660	COG1113	amino acid transport
I6G75_RS20665	COG2252	PERMEase
I6G75_RS20680	COG2153	protein acetylation
I6G75_RS20690	COG0475	glutathione-regulated potassium exporter activity
I6G75_RS20690	COG0569	domain protein
I6G75_RS20705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G75_RS20710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G75_RS20715	COG4990	cell redox homeostasis
I6G75_RS20730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G75_RS20735	COG0697	spore germination
I6G75_RS20740	COG0531	amino acid
I6G75_RS20750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6G75_RS20755	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6G75_RS20760	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6G75_RS20760	COG1918	ferrous iron import across plasma membrane
I6G75_RS20765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G75_RS20770	COG0573	inorganic phosphate transmembrane transporter activity
I6G75_RS20775	COG0581	inorganic phosphate transmembrane transporter activity
I6G75_RS20785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G75_RS20905	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6G75_RS20925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G75_RS20930	COG1116	anion transmembrane transporter activity
I6G75_RS20935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G75_RS20940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G75_RS20945	COG0352	thiamine-phosphate diphosphorylase activity
I6G75_RS20950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G75_RS20955	COG2104	thiamine diphosphate biosynthetic process
I6G75_RS20965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G75_RS20970	COG0351	phosphomethylpyrimidine kinase
I6G75_RS21010	COG2205	protein histidine kinase activity
I6G75_RS21015	COG2814	Major facilitator Superfamily
I6G75_RS21020	COG1846	Transcriptional regulator
I6G75_RS21045	COG1136	(ABC) transporter
I6G75_RS21045	COG0577	efflux transmembrane transporter activity
I6G75_RS21055	COG2252	PERMEase
I6G75_RS21060	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS21075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G75_RS21080	COG1621	beta-fructofuranosidase activity
I6G75_RS21085	COG1263	PTS System
I6G75_RS21085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G75_RS21090	COG1609	Transcriptional regulator
I6G75_RS21100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G75_RS21140	COG0778	Nitroreductase
I6G75_RS21145	COG2719	SpoVR family
I6G75_RS21155	COG1937	Protein conserved in bacteria
I6G75_RS21160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G75_RS21160	COG0425	Belongs to the sulfur carrier protein TusA family
I6G75_RS21165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G75_RS21165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G75_RS21170	COG0425	Belongs to the sulfur carrier protein TusA family
I6G75_RS21175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G75_RS21185	COG2210	Belongs to the sulfur carrier protein TusA family
I6G75_RS21190	COG0730	response to heat
I6G75_RS21200	COG1316	TRANSCRIPTIONal
I6G75_RS21205	COG0604	alcohol dehydrogenase
I6G75_RS21210	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6G75_RS21225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G75_RS21225	COG3711	transcriptional antiterminator
I6G75_RS21230	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G75_RS21235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G75_RS21255	COG3584	3D domain protein
I6G75_RS21255	COG1388	LysM domain
I6G75_RS21260	COG0577	efflux transmembrane transporter activity
I6G75_RS21265	COG1136	(ABC) transporter
I6G75_RS21275	COG5522	Integral membrane protein (intg_mem_TP0381)
I6G75_RS21290	COG0577	efflux transmembrane transporter activity
I6G75_RS21295	COG1114	Component of the transport system for branched-chain amino acids
I6G75_RS21300	COG3546	catalase activity
I6G75_RS21335	COG0586	Pfam SNARE associated Golgi protein
I6G75_RS21370	COG0531	amino acid
I6G75_RS21375	COG0475	glutathione-regulated potassium exporter activity
I6G75_RS21385	COG1737	Transcriptional regulator
I6G75_RS21395	COG1263	PTS System
I6G75_RS21395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G75_RS21410	COG2259	Doxx family
I6G75_RS21430	COG1522	sequence-specific DNA binding
I6G75_RS21445	COG2076	Multidrug Resistance protein
I6G75_RS21450	COG1309	transcriptional regulator
I6G75_RS21455	COG2814	Major facilitator Superfamily
I6G75_RS21460	COG4533	DNA binding
I6G75_RS21465	COG2211	Major facilitator Superfamily
I6G75_RS21475	COG0693	protein deglycase activity
I6G75_RS21480	COG0753	catalase activity
I6G75_RS21480	COG0693	protein deglycase activity
I6G75_RS21490	COG0531	amino acid
I6G75_RS21505	COG1012	belongs to the aldehyde dehydrogenase family
I6G75_RS21510	COG1132	(ABC) transporter
I6G75_RS21515	COG1132	(ABC) transporter
I6G75_RS21520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G75_RS21525	COG0765	amino acid transport
I6G75_RS21530	COG1126	abc transporter atp-binding protein
I6G75_RS21545	COG0189	ligase activity
I6G75_RS21575	COG0028	Belongs to the TPP enzyme family
I6G75_RS21580	COG3527	Alpha-acetolactate decarboxylase
I6G75_RS21590	COG0561	phosphatase activity
I6G75_RS21595	COG3409	Peptidoglycan-binding domain 1 protein
I6G75_RS21595	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6G75_RS21600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G75_RS21615	COG0659	secondary active sulfate transmembrane transporter activity
I6G75_RS21645	COG2244	polysaccharide biosynthetic process
I6G75_RS21655	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G75_RS21660	COG4196	transglutaminase domain protein
I6G75_RS21680	COG1024	Enoyl-CoA hydratase
I6G75_RS21700	COG1363	Peptidase, m42
I6G75_RS21720	COG3938	Belongs to the proline racemase family
I6G75_RS21740	COG0601	transmembrane transport
I6G75_RS21745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G75_RS21750	COG0444	Belongs to the ABC transporter superfamily
I6G75_RS21755	COG4608	Belongs to the ABC transporter superfamily
I6G75_RS21785	COG0477	Major facilitator Superfamily
I6G75_RS21790	COG3290	protein histidine kinase activity
I6G75_RS21795	COG4565	transcriptional regulatory protein
I6G75_RS21800	COG3181	Tripartite tricarboxylate transporter family receptor
I6G75_RS21810	COG0582	viral genome integration into host DNA
I6G75_RS21835	COG1401	restriction endodeoxyribonuclease activity
I6G75_RS21850	COG1401	restriction endodeoxyribonuclease activity
I6G75_RS21875	COG0305	Participates in initiation and elongation during chromosome replication
I6G75_RS21900	COG0477	Major facilitator Superfamily
I6G75_RS21945	COG3320	Male sterility
I6G75_RS21945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G75_RS21950	COG1309	transcriptional regulator
I6G75_RS21965	COG1183	phosphatidylcholine synthase activity
I6G75_RS21995	COG2376	Dihydroxyacetone kinase
I6G75_RS22005	COG2376	Dihydroxyacetone kinase
I6G75_RS22010	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6G75_RS22015	COG1959	2 iron, 2 sulfur cluster binding
I6G75_RS22030	COG0457	Tetratricopeptide repeat
I6G75_RS22040	COG2770	Histidine kinase
I6G75_RS22040	COG3437	response regulator, receiver
I6G75_RS22090	COG3237	CsbD-like
I6G75_RS22115	COG1191	sigma factor activity
I6G75_RS22125	COG2208	phosphoserine phosphatase activity
I6G75_RS22130	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G75_RS22135	COG2198	Histidine kinase
I6G75_RS22135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G75_RS22135	COG0784	Response regulator, receiver
I6G75_RS22135	COG2205	protein histidine kinase activity
I6G75_RS22200	COG0420	3'-5' exonuclease activity
I6G75_RS22205	COG4717	serine-type aminopeptidase activity
I6G75_RS22240	COG0346	lactoylglutathione lyase activity
I6G75_RS22245	COG0346	lactoylglutathione lyase activity
I6G75_RS22250	COG0457	Tetratricopeptide repeat
I6G75_RS22260	COG2267	carboxylic ester hydrolase activity
I6G75_RS22280	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6G75_RS22285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G75_RS22295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G75_RS22340	COG0477	Major facilitator Superfamily
I6G75_RS22345	COG0477	Major facilitator Superfamily
I6G75_RS22355	COG3973	AAA domain
I6G75_RS22360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G75_RS22380	COG4980	gas vesicle protein
I6G75_RS22385	COG0537	adenosine 5'-monophosphoramidase activity
I6G75_RS22390	COG1131	(ABC) transporter
I6G75_RS22395	COG4473	ABC transporter
I6G75_RS22455	COG1309	transcriptional regulator
I6G75_RS22465	COG3402	PFAM membrane-flanked domain
I6G75_RS22470	COG3428	Bacterial PH domain
I6G75_RS22520	COG3402	PFAM membrane-flanked domain
I6G75_RS22525	COG3428	Bacterial PH domain
I6G75_RS22530	COG2329	Antibiotic biosynthesis monooxygenase
I6G75_RS22535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G75_RS22550	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6G75_RS22590	COG1309	transcriptional regulator
I6G75_RS22595	COG1511	domain protein
I6G75_RS22625	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6G75_RS22635	COG2378	regulation of single-species biofilm formation
I6G75_RS22640	COG1609	Transcriptional regulator
I6G75_RS22650	COG1234	tRNA 3'-trailer cleavage
I6G75_RS22655	COG0095	Lipoate-protein ligase
I6G75_RS22665	COG0318	PFAM AMP-dependent synthetase and ligase
I6G75_RS22720	COG1073	alpha beta
I6G75_RS22725	COG1408	metallophosphoesterase
I6G75_RS22735	COG1078	dGTPase activity
I6G75_RS22745	COG1595	DNA-templated transcription, initiation
I6G75_RS22750	COG3708	Transcriptional regulator
I6G75_RS22750	COG2207	Transcriptional regulator
I6G75_RS22755	COG2205	protein histidine kinase activity
I6G75_RS22760	COG0745	RESPONSE REGULATOR receiver
I6G75_RS22780	COG0501	Belongs to the peptidase M48B family
I6G75_RS22785	COG0697	spore germination
I6G75_RS22805	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G75_RS22810	COG2224	Isocitrate lyase
I6G75_RS22820	COG1278	Cold shock
I6G75_RS22840	COG0398	Pfam SNARE associated Golgi protein
I6G75_RS22900	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G75_RS22925	COG0367	asparagine synthase
I6G75_RS22930	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G75_RS22935	COG0753	catalase activity
I6G75_RS22940	COG0004	ammonium transporteR
I6G75_RS22960	COG2996	Protein conserved in bacteria
I6G75_RS22970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G75_RS22980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G75_RS22995	COG0561	phosphatase activity
I6G75_RS23005	COG0542	response to heat
I6G75_RS23015	COG2267	carboxylic ester hydrolase activity
I6G75_RS23030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G75_RS23035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G75_RS23040	COG5504	Zn-dependent protease
I6G75_RS23050	COG0180	Tryptophanyl-tRNA synthetase
I6G75_RS23060	COG4166	transmembrane transport
I6G75_RS23065	COG0601	transmembrane transport
I6G75_RS23070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G75_RS23075	COG0444	Belongs to the ABC transporter superfamily
I6G75_RS23080	COG4608	Belongs to the ABC transporter superfamily
I6G75_RS23085	COG0534	Mate efflux family protein
I6G75_RS23090	COG4166	transmembrane transport
I6G75_RS23105	COG0861	Integral membrane protein TerC family
I6G75_RS23110	COG4862	establishment of competence for transformation
I6G75_RS23115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G75_RS23125	COG1164	Oligoendopeptidase f
I6G75_RS23140	COG2346	COG2346, Truncated hemoglobins
I6G75_RS23145	COG4116	CYTH
I6G75_RS23155	COG2357	RelA SpoT domain protein
I6G75_RS23165	COG0564	pseudouridine synthase activity
I6G75_RS23180	COG0772	Belongs to the SEDS family
I6G75_RS23185	COG1216	Glycosyl transferase, family 2
I6G75_RS23205	COG0463	Glycosyl transferase, family 2
I6G75_RS23205	COG0457	Tetratricopeptide repeat
I6G75_RS23225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6G75_RS23240	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6G75_RS23285	COG2153	protein acetylation
I6G75_RS23295	COG2382	esterase
I6G75_RS23310	COG5492	domain, Protein
I6G75_RS23315	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G75_RS23325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G75_RS23325	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G75_RS23360	COG1620	l-lactate permease
I6G75_RS23365	COG5634	Uncharacterized conserved protein (DUF2278)
I6G75_RS23420	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G75_RS23430	COG1476	TRANSCRIPTIONal
I6G75_RS23490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G75_RS23505	COG4152	abc transporter atp-binding protein
I6G75_RS23510	COG1668	transmembrane transport
I6G75_RS23525	COG2226	methyltransferase
I6G75_RS23535	COG1686	Belongs to the peptidase S11 family
I6G75_RS23540	COG0681	Belongs to the peptidase S26 family
I6G75_RS23575	COG1012	belongs to the aldehyde dehydrogenase family
I6G75_RS23585	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G75_RS23590	COG1177	transmembrane transport
I6G75_RS23595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G75_RS23605	COG2409	Drug exporters of the RND superfamily
I6G75_RS23615	COG0564	pseudouridine synthase activity
I6G75_RS23625	COG2340	Cysteine-rich secretory protein family
I6G75_RS23630	COG0247	lactate metabolic process
I6G75_RS23635	COG0277	FAD linked oxidase domain protein
I6G75_RS23640	COG3835	regulator
I6G75_RS23650	COG0745	RESPONSE REGULATOR receiver
I6G75_RS23655	COG5002	protein histidine kinase activity
I6G75_RS23660	COG2186	Transcriptional regulator
I6G75_RS23680	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6G75_RS23690	COG2116	formate transmembrane transporter activity
I6G75_RS23695	COG0861	Integral membrane protein TerC family
I6G75_RS23700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G75_RS23710	COG2030	dehydratase
I6G75_RS23730	COG1028	Short-chain dehydrogenase reductase Sdr
I6G75_RS23735	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6G75_RS23740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G75_RS23745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G75_RS23760	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G75_RS23765	COG3842	ATPase activity
I6G75_RS23790	COG1349	DNA-binding transcription factor activity
I6G75_RS23800	COG0235	Class ii aldolase
I6G75_RS23810	COG2861	carbohydrate metabolic process
I6G75_RS23820	COG3852	Histidine kinase
I6G75_RS23825	COG1846	Transcriptional regulator
I6G75_RS23835	COG2318	DinB family
I6G75_RS23840	COG5002	protein histidine kinase activity
I6G75_RS23850	COG0720	synthase
I6G75_RS23865	COG4873	Protein conserved in bacteria
I6G75_RS23895	COG1780	Probably involved in ribonucleotide reductase function
I6G75_RS23900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G75_RS23905	COG1403	HNH endonuclease
I6G75_RS23915	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G75_RS23920	COG1725	Transcriptional regulator
I6G75_RS23925	COG1131	(ABC) transporter
I6G75_RS23935	COG1131	(ABC) transporter
I6G75_RS23940	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G75_RS23955	COG1522	sequence-specific DNA binding
I6G75_RS23965	COG1335	isochorismatase
I6G75_RS23975	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G75_RS23980	COG2070	2-Nitropropane dioxygenase
I6G75_RS23985	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6G75_RS23995	COG1696	Membrane protein involved in D-alanine export
I6G75_RS24020	COG0716	FMN binding
I6G75_RS24075	COG1846	Transcriptional regulator
I6G75_RS24085	COG1301	dicarboxylic acid transport
I6G75_RS24090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G75_RS24095	COG4709	membrane
I6G75_RS24100	COG3874	Sporulation protein YtfJ
I6G75_RS24125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G75_RS24130	COG0028	Belongs to the TPP enzyme family
I6G75_RS24135	COG0440	acetolactate synthase activity
I6G75_RS24210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G75_RS24220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G75_RS24225	COG1183	phosphatidylcholine synthase activity
I6G75_RS24230	COG1368	sulfuric ester hydrolase activity
I6G75_RS24240	COG0019	diaminopimelate decarboxylase activity
I6G75_RS24260	COG0529	Catalyzes the synthesis of activated sulfate
I6G75_RS24265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G75_RS24285	COG1648	precorrin-2 dehydrogenase activity
I6G75_RS24290	COG0733	neurotransmitter:sodium symporter activity
I6G75_RS24320	COG1757	Na H antiporter
I6G75_RS24335	COG4758	membrane
I6G75_RS24340	COG4585	Histidine kinase
I6G75_RS24345	COG2197	response regulator
I6G75_RS24355	COG1114	Component of the transport system for branched-chain amino acids
I6G75_RS24365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G75_RS24405	COG0730	response to heat
I6G75_RS24410	COG0306	phosphate transporter
I6G75_RS24415	COG1392	Phosphate transport regulator
I6G75_RS24420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G75_RS24435	COG3852	Histidine kinase
I6G75_RS24440	COG1801	Protein of unknown function DUF72
I6G75_RS24450	COG0582	viral genome integration into host DNA
I6G75_RS24455	COG5002	protein histidine kinase activity
I6G75_RS24475	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6G75_RS24475	COG0392	lysyltransferase activity
I6G75_RS24490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G75_RS24495	COG1686	Belongs to the peptidase S11 family
I6G75_RS24500	COG2715	membrane protein required for spore maturation
I6G75_RS24505	COG0700	Nucleoside recognition
I6G75_RS24510	COG1187	pseudouridine synthase activity
I6G75_RS24520	COG1333	cytochrome c biogenesis protein
I6G75_RS24525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G75_RS24530	COG0745	RESPONSE REGULATOR receiver
I6G75_RS24535	COG5002	protein histidine kinase activity
I6G75_RS24540	COG2096	Adenosyltransferase
I6G75_RS24545	COG4942	peptidase
I6G75_RS24555	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6G75_RS24560	COG1141	Ferredoxin
I6G75_RS24575	COG1266	CAAX protease self-immunity
I6G75_RS24585	COG1408	metallophosphoesterase
I6G75_RS24595	COG4862	establishment of competence for transformation
I6G75_RS24600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G75_RS24620	COG0492	ferredoxin-NADP+ reductase activity
I6G75_RS24695	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G75_RS24710	COG0142	geranyltranstransferase activity
I6G75_RS24720	COG0142	geranyltranstransferase activity
I6G75_RS24740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G75_RS24745	COG0457	Tetratricopeptide repeat
I6G75_RS24765	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G75_RS24775	COG4347	Protein of unknown function (DUF1405)
I6G75_RS24790	COG2738	Putative neutral zinc metallopeptidase
I6G75_RS24800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G75_RS24805	COG1694	Mazg nucleotide pyrophosphohydrolase
I6G75_RS24820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G75_RS24825	COG0438	transferase activity, transferring glycosyl groups
I6G75_RS24860	COG1199	ATP-dependent helicase activity
I6G75_RS24860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G75_RS24880	COG3935	DnaD domain protein
I6G75_RS24885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G75_RS24895	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6G75_RS24895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G75_RS24955	COG0116	Belongs to the methyltransferase superfamily
I6G75_RS24965	COG1199	ATP-dependent helicase activity
I6G75_RS24970	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6G75_RS24980	COG3173	Aminoglycoside phosphotransferase
I6G75_RS24985	COG0024	Methionine aminopeptidase
I6G75_RS24995	COG2233	PERMEase
I6G75_RS25000	COG2311	Membrane
I6G75_RS25005	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G75_RS25015	COG0456	acetyltransferase
I6G75_RS25055	COG0754	glutathionylspermidine amidase activity
I6G75_RS25070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G75_RS25085	COG0454	-acetyltransferase
I6G75_RS25105	COG0328	RNA-DNA hybrid ribonuclease activity
I6G75_RS25140	COG3403	YqcI/YcgG family
I6G75_RS25145	COG1280	lysine exporter protein (LysE YggA)
I6G75_RS25160	COG3162	membrane
I6G75_RS25165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G75_RS25170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G75_RS25180	COG0475	glutathione-regulated potassium exporter activity
I6G75_RS25185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G75_RS25190	COG4978	Transcriptional regulator
I6G75_RS25190	COG0789	Transcriptional regulator
I6G75_RS25200	COG2323	membrane
I6G75_RS25205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6G75_RS25260	COG1923	regulation of RNA biosynthetic process
I6G75_RS25270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G75_RS25275	COG1360	Flagellar Motor Protein
I6G75_RS25280	COG2201	protein-glutamate methylesterase activity
I6G75_RS25285	COG2198	Histidine kinase
I6G75_RS25285	COG0643	Histidine kinase
I6G75_RS25290	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G75_RS25290	COG1776	CheC inhibitor of MCP methylation
I6G75_RS25305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G75_RS25325	COG1256	bacterial-type flagellum assembly
I6G75_RS25330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G75_RS25335	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6G75_RS25350	COG1815	bacterial-type flagellum-dependent cell motility
I6G75_RS25355	COG1558	bacterial-type flagellum-dependent cell motility
I6G75_RS25365	COG1766	The M ring may be actively involved in energy transduction
I6G75_RS25370	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G75_RS25380	COG1157	protein secretion by the type III secretion system
I6G75_RS25415	COG0835	chemotaxis
I6G75_RS25415	COG0784	Response regulator, receiver
I6G75_RS25425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G75_RS25430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G75_RS25435	COG0741	lytic transglycosylase activity
I6G75_RS25445	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G75_RS25450	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G75_RS25450	COG1776	CheC inhibitor of MCP methylation
I6G75_RS25460	COG1338	Plays a role in the flagellum-specific transport system
I6G75_RS25465	COG1987	bacterial-type flagellum assembly
I6G75_RS25475	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G75_RS25480	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G75_RS25485	COG1419	protein localization to endoplasmic reticulum
I6G75_RS25490	COG4786	Flagellar basal body rod
I6G75_RS25495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G75_RS25540	COG2329	Antibiotic biosynthesis monooxygenase
I6G75_RS25565	COG0583	DNA-binding transcription factor activity
I6G75_RS25570	COG3842	ATPase activity
I6G75_RS25575	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G75_RS25585	COG1234	tRNA 3'-trailer cleavage
I6G75_RS25615	COG1686	Belongs to the peptidase S11 family
I6G75_RS25625	COG0406	alpha-ribazole phosphatase activity
I6G75_RS25645	COG1846	Transcriptional regulator
I6G75_RS25655	COG0367	asparagine synthase
I6G75_RS25685	COG1802	Transcriptional regulator
I6G75_RS25690	COG0697	spore germination
I6G75_RS25695	COG0523	cobalamin synthesis protein
I6G75_RS25700	COG0701	Predicted permease
I6G75_RS25715	COG1757	Na H antiporter
I6G75_RS25720	COG0114	fumarate hydratase activity
I6G75_RS25735	COG0534	Mate efflux family protein
I6G75_RS25740	COG3340	Belongs to the peptidase S51 family
I6G75_RS25760	COG0785	Cytochrome C biogenesis protein
I6G75_RS25790	COG2733	membrane
I6G75_RS25825	COG1131	(ABC) transporter
I6G75_RS25840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G75_RS25845	COG0528	UMP kinase activity
I6G75_RS25855	COG1027	Aspartate ammonia-lyase
I6G75_RS25860	COG0281	malic enzyme
I6G75_RS25865	COG4191	Histidine kinase
I6G75_RS25870	COG0784	Response regulator, receiver
I6G75_RS25875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G75_RS25930	COG1051	belongs to the nudix hydrolase family
I6G75_RS25945	COG2814	Major facilitator Superfamily
I6G75_RS25960	COG1966	Carbon starvation protein
I6G75_RS25970	COG1695	Transcriptional regulator
I6G75_RS25980	COG0477	Major facilitator Superfamily
I6G75_RS25985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G75_RS25990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G75_RS25995	COG4166	transmembrane transport
I6G75_RS26000	COG2223	nitrite transmembrane transporter activity
I6G75_RS26005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G75_RS26020	COG2244	polysaccharide biosynthetic process
I6G75_RS26025	COG0733	neurotransmitter:sodium symporter activity
I6G75_RS26035	COG5566	PFAM Mor transcription activator
I6G75_RS26040	COG2323	membrane
I6G75_RS26055	COG2084	Dehydrogenase
I6G75_RS26070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G75_RS26080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G75_RS26085	COG0028	Belongs to the TPP enzyme family
I6G75_RS26095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G75_RS26105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G75_RS26130	COG2814	Major facilitator Superfamily
I6G75_RS26135	COG3384	dioxygenase
I6G75_RS26155	COG3279	Response regulator of the LytR AlgR family
I6G75_RS26160	COG0427	acetyl-CoA hydrolase
I6G75_RS26195	COG0582	viral genome integration into host DNA
I6G75_RS26205	COG3620	sequence-specific DNA binding
I6G75_RS26250	COG1846	Transcriptional regulator
I6G75_RS26255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G75_RS26340	COG0582	viral genome integration into host DNA
I6G75_RS26475	COG4166	transmembrane transport
I6G75_RS26500	COG0535	radical SAM domain protein
I6G75_RS26505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G75_RS26510	COG0745	RESPONSE REGULATOR receiver
I6G75_RS26530	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G75_RS26545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G75_RS26550	COG0531	amino acid
I6G75_RS26575	COG2390	Transcriptional regulator
I6G75_RS26585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G75_RS26590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6G75_RS26600	COG4846	Membrane protein involved in cytochrome C biogenesis
I6G75_RS26620	COG0006	proline dipeptidase activity
I6G75_RS26625	COG2132	Multicopper oxidase
I6G75_RS26640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G75_RS26660	COG1114	Component of the transport system for branched-chain amino acids
I6G75_RS26670	COG1276	copper resistance
I6G75_RS26670	COG2372	response to copper ion
I6G75_RS26675	COG4549	nuclear export factor GLE1
I6G75_RS26685	COG0697	spore germination
I6G75_RS26690	COG0583	DNA-binding transcription factor activity
I6G75_RS26695	COG1959	2 iron, 2 sulfur cluster binding
I6G75_RS26700	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G75_RS26705	COG0778	Nitroreductase
I6G75_RS26715	COG0628	permease
I6G75_RS26725	COG1231	oxidoreductase activity
I6G75_RS26730	COG0523	cobalamin synthesis protein
I6G75_RS26745	COG0318	PFAM AMP-dependent synthetase and ligase
I6G75_RS26750	COG2030	dehydratase
I6G75_RS26755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G75_RS26765	COG0411	ABC transporter
I6G75_RS26785	COG0583	DNA-binding transcription factor activity
I6G75_RS26795	COG1942	4-Oxalocrotonate Tautomerase
I6G75_RS26815	COG1271	oxidase subunit
I6G75_RS26820	COG1294	oxidase, subunit
I6G75_RS26825	COG4988	ABC transporter
I6G75_RS26830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6G75_RS26845	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G75_RS26850	COG1686	Belongs to the peptidase S11 family
I6G75_RS26865	COG1388	LysM domain
I6G75_RS26865	COG0791	NLP P60 protein
I6G75_RS26875	COG1132	(ABC) transporter
I6G75_RS26880	COG0745	RESPONSE REGULATOR receiver
I6G75_RS26885	COG5002	protein histidine kinase activity
I6G75_RS26890	COG0300	oxidoreductase activity
I6G75_RS26895	COG4122	O-methyltransferase activity
I6G75_RS26925	COG0460	homoserine dehydrogenase
I6G75_RS26950	COG1316	TRANSCRIPTIONal
I6G75_RS26960	COG0745	RESPONSE REGULATOR receiver
I6G75_RS26965	COG5002	protein histidine kinase activity
I6G75_RS26980	COG1285	pathogenesis
I6G75_RS26985	COG1247	-acetyltransferase
I6G75_RS27005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G75_RS27015	COG1082	Xylose isomerase domain protein TIM barrel
I6G75_RS27025	COG2814	Major facilitator Superfamily
I6G75_RS27030	COG1279	arginine transmembrane transporter activity
I6G75_RS27035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G75_RS27045	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G75_RS27145	COG4695	Portal protein
I6G75_RS27175	COG0577	efflux transmembrane transporter activity
I6G75_RS27180	COG2002	toxin-antitoxin pair type II binding
I6G75_RS27185	COG1404	Belongs to the peptidase S8 family
I6G75_RS27190	COG0640	Transcriptional regulator
I6G75_RS27195	COG0667	Aldo Keto reductase
I6G75_RS27200	COG2814	Major facilitator Superfamily
I6G75_RS27225	COG0840	transmembrane signaling receptor activity
I6G75_RS27240	COG3949	Membrane
I6G75_RS27245	COG0783	Belongs to the Dps family
I6G75_RS27260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G75_RS27270	COG1231	oxidoreductase activity
I6G75_RS27275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G75_RS27280	COG4989	oxidoreductase activity
I6G75_RS27285	COG0523	cobalamin synthesis protein
I6G75_RS27290	COG0456	acetyltransferase
I6G75_RS27310	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G75_RS27310	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G75_RS27320	COG0702	epimerase
I6G75_RS27330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G75_RS27340	COG4166	transmembrane transport
I6G75_RS27355	COG0406	alpha-ribazole phosphatase activity
I6G75_RS27365	COG5337	Spore coat protein CotH
I6G75_RS27370	COG1051	belongs to the nudix hydrolase family
I6G75_RS27375	COG0586	Pfam SNARE associated Golgi protein
I6G75_RS27380	COG2244	polysaccharide biosynthetic process
I6G75_RS27390	COG0701	Predicted permease
I6G75_RS27395	COG3689	TIGRFAM TIGR03943 family protein
I6G75_RS27400	COG1607	acyl-coa hydrolase
I6G75_RS27410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G75_RS27425	COG0702	epimerase
I6G75_RS27430	COG2839	Protein conserved in bacteria
I6G75_RS27435	COG1253	flavin adenine dinucleotide binding
I6G75_RS27450	COG1114	Component of the transport system for branched-chain amino acids
I6G75_RS27455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G75_RS27475	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G75_RS27485	COG1876	peptidase activity
I6G75_RS27495	COG0154	amidase activity
I6G75_RS27500	COG2211	Major facilitator Superfamily
I6G75_RS27515	COG2368	4-hydroxyphenylacetate
I6G75_RS27525	COG0196	riboflavin kinase activity
I6G75_RS27540	COG0251	oxidation-reduction process
I6G75_RS27550	COG3971	2-oxopent-4-enoate hydratase activity
I6G75_RS27570	COG1942	4-Oxalocrotonate Tautomerase
I6G75_RS27580	COG0561	phosphatase activity
I6G75_RS27590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G75_RS27595	COG4106	trans-aconitate 2-methyltransferase activity
I6G75_RS27610	COG1819	glycosyl
I6G75_RS27615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G75_RS27620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G75_RS27650	COG0456	acetyltransferase
I6G75_RS27725	COG3874	Sporulation protein YtfJ
I6G75_RS27750	COG2226	methyltransferase
I6G75_RS27775	COG0346	lactoylglutathione lyase activity
I6G75_RS27790	COG1595	DNA-templated transcription, initiation
I6G75_RS27805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G75_RS27805	COG0426	domain, Protein
I6G75_RS27815	COG0386	Belongs to the glutathione peroxidase family
I6G75_RS27820	COG1305	Transglutaminase-like
I6G75_RS27825	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I6G75_RS27830	COG0714	Associated with various cellular activities
I6G75_RS27845	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G75_RS27850	COG1140	nitrate reductase beta subunit
I6G75_RS27855	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G75_RS27860	COG2181	nitrate reductase activity
I6G75_RS27865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G75_RS27870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G75_RS27875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G75_RS27880	COG0303	'Molybdopterin
I6G75_RS27885	COG0314	molybdopterin synthase activity
I6G75_RS27895	COG2223	nitrite transmembrane transporter activity
I6G75_RS27905	COG1648	precorrin-2 dehydrogenase activity
I6G75_RS27915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G75_RS27915	COG1587	Uroporphyrinogen-III synthase
I6G75_RS27920	COG2146	nitrite reductase [NAD(P)H] activity
I6G75_RS27925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G75_RS27930	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6G75_RS27965	COG2359	stage V sporulation protein S
I6G75_RS28025	COG1418	mRNA catabolic process
I6G75_RS28030	COG0488	(ABC) transporter
I6G75_RS28045	COG0629	single-stranded DNA binding
I6G75_RS28060	COG1413	lyase activity
I6G75_RS28075	COG2521	methyltransferase
I6G75_RS28075	COG2136	Putative SAM-dependent methyltransferase