locus-tag class description F3L01_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F3L01_RS00015 ENOG410848D S4 domain protein YaaA F3L01_RS00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F3L01_RS00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) F3L01_RS00100 ENOG4105ZMH deoxynucleoside kinase F3L01_RS00110 ENOG4105GTG Isochorismatase F3L01_RS00115 ENOG4108Z6B deaminase F3L01_RS00125 ENOG4105C6E dna polymerase iii F3L01_RS00145 ENOG41067KS pro-sigma K processing F3L01_RS00180 ENOG4105CXN decarboxylase F3L01_RS00185 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) F3L01_RS00190 ENOG4105FA2 dna polymerase iii F3L01_RS00195 ENOG4105MA4 psp1 domain protein F3L01_RS00205 ENOG41060K3 Methyltransferase F3L01_RS00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) F3L01_RS00220 ENOG4105KRN Transcriptional regulator, abrb family F3L01_RS00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) F3L01_RS00230 ENOG4105F8V Hydrolase, tatD family F3L01_RS00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) F3L01_RS00245 ENOG4105XFA sporulation peptidase YabG F3L01_RS00250 ENOG4105W42 Veg protein F3L01_RS00265 ENOG4105DFT pur operon repressor F3L01_RS00270 ENOG4105KME endoribonuclease L-psp F3L01_RS00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) F3L01_RS00300 ENOG4108JA2 transcriptioN-repair coupling factor F3L01_RS00305 ENOG4108M14 stage v sporulation protein t F3L01_RS00315 ENOG4108IY2 MazG family F3L01_RS00320 ENOG41082I2 s4 domain protein F3L01_RS00325 ENOG4105VYY sporulation protein yabp F3L01_RS00340 ENOG41060GV RNA binding s1 domain protein F3L01_RS00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) F3L01_RS00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase F3L01_RS00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) F3L01_RS00385 ENOG4105C6T cysteine synthase F3L01_RS00390 ENOG4105CRQ synthase (Component I) F3L01_RS00395 ENOG4105DDQ anthranilate synthase F3L01_RS00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 F3L01_RS00405 ENOG4105EEI dihydropteroate synthase F3L01_RS00410 ENOG4105KRF dihydroneopterin aldolase F3L01_RS00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase F3L01_RS00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F3L01_RS00515 ENOG4108Z0C Uvrb UvrC protein F3L01_RS00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) F3L01_RS00535 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) F3L01_RS00540 ENOG4105CTP PilT protein domain protein F3L01_RS00545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) F3L01_RS00560 ENOG4105D7W serine acetyltransferase F3L01_RS00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 F3L01_RS00580 ENOG4105M0M Tetracycline resistance protein F3L01_RS00585 ENOG4105QIV RNA polymerase F3L01_RS00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) F3L01_RS00625 ENOG4107Y49 methyltransferase F3L01_RS00640 ENOG4105XPM ribosomal protein F3L01_RS00770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F3L01_RS00780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F3L01_RS00815 ENOG4108JJB ABC transporter F3L01_RS00820 ENOG4108JJB ABC transporter F3L01_RS00825 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) F3L01_RS00830 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) F3L01_RS00855 ENOG4105D1F ATP-binding protein F3L01_RS00870 ENOG4108NMV polysaccharide deacetylase F3L01_RS00950 ENOG4105C8B TIGR00159 family F3L01_RS00955 ENOG4107U5W ybbr family F3L01_RS00970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F3L01_RS00995 ENOG4108PSK reductase F3L01_RS01000 ENOG4108UMI ABC transporter, permease F3L01_RS01005 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F3L01_RS01010 ENOG4105D01 (LipO)protein F3L01_RS01015 ENOG4105CB2 alcohol dehydrogenase F3L01_RS01025 ENOG4105IQ5 FAD linked oxidase domain protein F3L01_RS01040 ENOG4105C2C drug resistance transporter, Bcr CflA F3L01_RS01060 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F3L01_RS01065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L01_RS01070 ENOG4105C3U ABC transporter F3L01_RS01075 ENOG4108JQ7 (ABC) transporter F3L01_RS01105 ENOG4108J59 Extracellular solute-binding protein, family 5 F3L01_RS01110 ENOG4108J59 Extracellular solute-binding protein, family 5 F3L01_RS01120 ENOG4105II7 pyrroline-5-carboxylate reductase F3L01_RS01130 ENOG4105E0C molybdate abc transporter F3L01_RS01135 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein F3L01_RS01140 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family F3L01_RS01150 ENOG4105EGI Transcriptional regulator F3L01_RS01170 ENOG4105F6E Acyl-transferase F3L01_RS01190 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) F3L01_RS01225 ENOG4105C5H ABC transporter F3L01_RS01235 ENOG4105DEF Extracellular solute-binding protein, family 5 F3L01_RS01245 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L01_RS01250 ENOG4105C3U ABC transporter F3L01_RS01255 ENOG4108JQ7 (ABC) transporter F3L01_RS01260 ENOG410667J hydrolase F3L01_RS01285 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase F3L01_RS01290 ENOG4105ERH Fumarylacetoacetate hydrolase F3L01_RS01300 ENOG4105CUB amino acid F3L01_RS01305 ENOG4108SC4 )-transporter F3L01_RS01310 ENOG4105CPF Cell wall formation (By similarity) F3L01_RS01315 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) F3L01_RS01340 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein F3L01_RS01345 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F3L01_RS01355 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) F3L01_RS01460 ENOG4105K8N protein family UPF0079, ATPase F3L01_RS01465 ENOG41072GX Peptidase M22 Glycoprotease F3L01_RS01470 ENOG410801F ribosomal-protein-alanine acetyltransferase F3L01_RS01475 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F3L01_RS01480 ENOG4105C5H ABC transporter F3L01_RS01495 ENOG4108TYN CAAX amino terminal protease family protein F3L01_RS01510 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F3L01_RS01515 ENOG4105C7N Xanthine uracil vitamin C permease F3L01_RS01525 ENOG4105BZU Histidine kinase F3L01_RS01550 ENOG4107ZXU DSBA oxidoreductase F3L01_RS01595 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_RS01625 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F3L01_RS01635 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) F3L01_RS01645 ENOG4108SHN Glycosyl transferase, family 2 F3L01_RS01665 ENOG4105SX7 Transporter F3L01_RS01690 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) F3L01_RS01695 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit F3L01_RS01700 ENOG4105C83 adenylosuccinate lyase F3L01_RS01710 ENOG4105VR9 phosphoribosylformylglycinamidine synthase F3L01_RS01720 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii F3L01_RS01735 ENOG4108V3E phosphoribosylglycinamide formyltransferase F3L01_RS01740 ENOG4105DC1 bifunctional purine biosynthesis protein purh F3L01_RS01745 ENOG4105C12 Phosphoribosylglycinamide synthetase F3L01_RS01770 ENOG4105C4R Atp-dependent dna helicase F3L01_RS01775 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) F3L01_RS01795 ENOG4108W2Y isochorismatase F3L01_RS01800 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F3L01_RS01805 ENOG4108UMI ABC transporter, permease F3L01_RS01810 ENOG4105D01 (LipO)protein F3L01_RS01830 ENOG410834F Transcriptional regulator F3L01_RS01835 ENOG4107I77 yiaA/B two helix domain F3L01_RS01845 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) F3L01_RS01855 ENOG4105CBD Diacylglycerol kinase F3L01_RS01865 ENOG4108JPW Aminotransferase F3L01_RS01875 ENOG4105C26 Dehydrogenase F3L01_RS01880 ENOG4105KPY Small multidrug resistance protein F3L01_RS01910 ENOG4105D9N nucleoside F3L01_RS01915 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) F3L01_RS01925 ENOG4108W15 Protein of unknown function (DUF1456) F3L01_RS01940 ENOG4105DTQ mandelate racemase muconate lactonizing F3L01_RS01950 ENOG4105DFD Na H antiporter F3L01_RS01970 ENOG4105D3R alkyl hydroperoxide reductase F3L01_RS01990 ENOG4105EHG Permease protein F3L01_RS01995 ENOG4105DQ5 transport system permease protein F3L01_RS02000 ENOG4108V5C ABC transporter F3L01_RS02020 ENOG4106UIA F3L01_RS02025 ENOG4106UIA F3L01_RS02040 ENOG4105BZU Histidine kinase F3L01_RS02060 ENOG410756H nucleotidyltransferase F3L01_RS02065 ENOG4105D2S major facilitator superfamily F3L01_RS02080 ENOG4105E5Q amino acid AbC transporter F3L01_RS02085 ENOG4105EAB amino acid AbC transporter F3L01_RS02090 ENOG4105CDA abc transporter atp-binding protein F3L01_RS02095 ENOG4105C8Q Methyl-accepting chemotaxis F3L01_RS02110 ENOG4105DBV ornithine carbamoyltransferase F3L01_RS02120 ENOG4105C5B carbamate kinase F3L01_RS02125 ENOG4108W63 CRP FNR family transcriptional regulator F3L01_RS02135 ENOG4105DNP FAD linked oxidase domain protein F3L01_RS02145 ENOG4105CI1 PTS System F3L01_RS02160 ENOG4105C9U ATP-dependent DNA helicase RecQ F3L01_RS02165 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase F3L01_RS02170 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) F3L01_RS02175 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter F3L01_RS02195 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component F3L01_RS02200 ENOG4105D2X ABC transporter substrate-binding protein F3L01_RS02240 ENOG41062JF Transcriptional regulator F3L01_RS02255 ENOG4105DEU major facilitator superfamily F3L01_RS02270 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) F3L01_RS02285 ENOG4108N0M stress protein F3L01_RS02290 ENOG4106FN3 tellurium resistance protein F3L01_RS02295 ENOG4106FN3 tellurium resistance protein F3L01_RS02300 ENOG4107TS3 membrane protein, TerC F3L01_RS02305 ENOG4108TTB tellurium resistance protein F3L01_RS02325 ENOG4105KJF protein tyrosine phosphatase F3L01_RS02335 ENOG4107U9T Pfam:Ribonuclease_BN F3L01_RS02340 ENOG4105C59 p-type ATPase F3L01_RS02345 ENOG4108IPJ Membrane F3L01_RS02365 ENOG4107ZTW SNARE associated Golgi F3L01_RS02380 ENOG410606W general stress protein F3L01_RS02385 ENOG4105UPD Calcium Proton F3L01_RS02420 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) F3L01_RS02425 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) F3L01_RS02435 ENOG4108JUB Transcriptional regulator F3L01_RS02445 ENOG4108IQI permease F3L01_RS02485 ENOG4108A04 Beta-lactamase F3L01_RS02500 ENOG4105CKK Glycosyl transferase, family 2 F3L01_RS02505 ENOG4107QQG Dehydrogenase F3L01_RS02510 ENOG4105C3I Nad-dependent epimerase dehydratase F3L01_RS02530 ENOG4105F1A Pyruvate formate-lyase F3L01_RS02535 ENOG4108QBV Monogalactosyldiacylglycerol synthase F3L01_RS02550 ENOG4105CI2 imidazolone-5-propionate hydrolase F3L01_RS02555 ENOG4105ECP epimerase F3L01_RS02585 ENOG41067AE Membrane-bound metal-dependent hydrolase F3L01_RS02590 ENOG4105CEN a g-specific adenine glycosylase F3L01_RS02595 ENOG4106BXE F3L01_RS02615 ENOG4105BZ1 (ABC) transporter F3L01_RS02620 ENOG4107NBY Membrane F3L01_RS02625 ENOG4105CBC glutamate synthase F3L01_RS02635 ENOG4108IUW ABC transporter F3L01_RS02655 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F3L01_RS02660 ENOG4105G5W regulator Fur family F3L01_RS02780 ENOG4108JQC penicillin-binding protein 1A F3L01_RS02785 ENOG4108R9S DSBA oxidoreductase F3L01_RS02795 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) F3L01_RS02805 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) F3L01_RS02810 ENOG4105BZU Histidine kinase F3L01_RS02815 ENOG4105CYN Serine protein kinase F3L01_RS02820 ENOG4106AKX UPF0229 protein F3L01_RS02835 ENOG4105C94 Transporter F3L01_RS02850 ENOG4105DZ6 Band 7 protein F3L01_RS02860 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism F3L01_RS02865 ENOG4108V9W transcriptional regulatory protein F3L01_RS02870 ENOG4105D4T Citrate transporter F3L01_RS02895 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator F3L01_RS02900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F3L01_RS02905 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component F3L01_RS02910 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component F3L01_RS02915 ENOG4105BZ7 extracellular solute-binding protein family 1 F3L01_RS02920 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) F3L01_RS02925 ENOG4108STX response regulator F3L01_RS02930 ENOG41062D9 Histidine kinase F3L01_RS02955 ENOG4108MRH transcriptional regulatory protein F3L01_RS02965 ENOG4105C6K Malic enzyme F3L01_RS02975 ENOG4108UZ3 Transporter F3L01_RS02980 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F3L01_RS02990 ENOG4105BZU Histidine kinase F3L01_RS02995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_RS03005 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) F3L01_RS03010 ENOG4108JB9 formate dehydrogenase F3L01_RS03045 ENOG4105C59 p-type ATPase F3L01_RS03085 ENOG41073R8 VanW family F3L01_RS03090 ENOG4108KGH TRANSCRIPTIONal F3L01_RS03095 ENOG4105D9N nucleoside F3L01_RS03100 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase F3L01_RS03105 ENOG4105C37 (CBS) domain F3L01_RS03110 ENOG4108IJ0 Aspartate ammonia-lyase F3L01_RS03115 ENOG4105DAA L-lactate F3L01_RS03130 ENOG4105DUX Transporter F3L01_RS03135 ENOG4108MES Periplasmic binding protein F3L01_RS03140 ENOG4105DQ5 transport system permease protein F3L01_RS03145 ENOG4108IHU transport system permease protein F3L01_RS03150 ENOG4105E0A ABC, transporter F3L01_RS03160 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F3L01_RS03165 ENOG4105EXW epimerase dehydratase F3L01_RS03175 ENOG4107T89 von Willebrand factor, type A F3L01_RS03180 ENOG4105GMT ATPase associated with various cellular activities aaa_5 F3L01_RS03185 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F3L01_RS03195 ENOG4105BZU Histidine kinase F3L01_RS03200 ENOG4105D5Q Arginine ornithine antiporter F3L01_RS03205 ENOG4107414 GntR family transcriptional regulator F3L01_RS03210 ENOG4105C5Y PTS System F3L01_RS03215 ENOG4105CG3 alpha amylase, catalytic region F3L01_RS03230 ENOG4105E1K spore germination protein F3L01_RS03235 ENOG4108XG2 Histidine kinase F3L01_RS03240 ENOG4105WH1 Two component transcriptional regulator luxr family F3L01_RS03245 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin F3L01_RS03255 ENOG4105CRN Aminoglycoside phosphotransferase F3L01_RS03260 ENOG4105BZG amino acid carrier protein F3L01_RS03265 ENOG4105CDA abc transporter atp-binding protein F3L01_RS03270 ENOG4105CT1 (ABC) transporter F3L01_RS03275 ENOG4105EAD ABC transporter F3L01_RS03280 ENOG4105DRP amino acid AbC transporter F3L01_RS03285 ENOG4108IQI permease F3L01_RS03310 ENOG4105D29 Helix-turn-helix type 11 domain protein F3L01_RS03315 ENOG4105NAE bifunctional deaminase-reductase domain protein F3L01_RS03320 ENOG4105BZU Histidine kinase F3L01_RS03325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_RS03335 ENOG4105CHH sulfate transporter F3L01_RS03340 ENOG41068KF Universal stress protein F3L01_RS03350 ENOG4105CXY transporter F3L01_RS03355 ENOG41067TZ transcriptional regulator, MarR family F3L01_RS03360 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L01_RS03365 ENOG4105ETE Transcriptional regulator (LacI family F3L01_RS03370 ENOG4108RVA ribokinase F3L01_RS03380 ENOG4105C2J ABC transporter F3L01_RS03385 ENOG4105CNN ABC, transporter F3L01_RS03390 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F3L01_RS03395 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F3L01_RS03425 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) F3L01_RS03455 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) F3L01_RS03460 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer F3L01_RS03465 ENOG41069ER domain protein F3L01_RS03470 ENOG4105VZ8 Transcriptional regulator F3L01_RS03475 ENOG4107D63 F3L01_RS03490 ENOG4105DUX Transporter F3L01_RS03510 ENOG4105C85 amino acid F3L01_RS03515 ENOG4105C7N Xanthine uracil vitamin C permease F3L01_RS03530 ENOG4105MA6 gCN5-related N-acetyltransferase F3L01_RS03560 ENOG4105E2S oxidase) subunit II F3L01_RS03580 ENOG4106CAD Protein of unknown function (DUF3311) F3L01_RS03585 ENOG4105E1V na solute symporter F3L01_RS03605 ENOG4105CE1 Ferrous iron transport protein b F3L01_RS03610 ENOG4105CE1 Ferrous iron transport protein b F3L01_RS03615 ENOG4105CE1 Ferrous iron transport protein b F3L01_RS03620 ENOG4105CVA phosphate F3L01_RS03625 ENOG4105C8U phosphate abc transporter F3L01_RS03630 ENOG4105E2Z phosphate ABC transporter (Permease F3L01_RS03755 ENOG41080XQ Signal transduction protein with cbs domains F3L01_RS03775 ENOG4105ETU transcriptional activator (TenA F3L01_RS03785 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component F3L01_RS03795 ENOG4108VEU Thiamine monophosphate synthase F3L01_RS03800 ENOG41080HI glycine oxidase F3L01_RS03815 ENOG4105D06 uba thif-type nad fad binding protein F3L01_RS03820 ENOG4105DWF phosphomethylpyrimidine kinase F3L01_RS03855 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) F3L01_RS03870 ENOG4108INS Transcriptional regulator F3L01_RS03880 ENOG4105C7N Xanthine uracil vitamin C permease F3L01_RS03890 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F3L01_RS03910 ENOG4105C5Y PTS System F3L01_RS03925 ENOG4105K63 Thioredoxin F3L01_RS03945 ENOG4108B31 Spore germination protein F3L01_RS03965 ENOG4107Y03 Nitroreductase F3L01_RS03985 ENOG4105ED1 spovr family F3L01_RS03995 ENOG4105J4Q Transcriptional regulator F3L01_RS04010 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase F3L01_RS04015 ENOG4105XTG Pfam:DUF156 F3L01_RS04020 ENOG4105VFE sira family F3L01_RS04025 ENOG4107TPS domain protein F3L01_RS04030 ENOG4105VFE sira family F3L01_RS04035 ENOG4105VFE sira family F3L01_RS04040 ENOG41085GJ domain protein F3L01_RS04045 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase F3L01_RS04050 ENOG41087NI Sulfite exporter TauE/SafE F3L01_RS04060 ENOG4108KGH TRANSCRIPTIONal F3L01_RS04085 ENOG4105EMD TRANSCRIPTIONal F3L01_RS04090 ENOG4105VCP PTS System F3L01_RS04095 ENOG4105VZJ PTS System F3L01_RS04115 ENOG41069ER domain protein F3L01_RS04120 ENOG4107RBB ABC transporter, permease F3L01_RS04125 ENOG4105C19 ABC transporter F3L01_RS04155 ENOG4105WEF catalase F3L01_RS04190 ENOG4107T5V SNARE associated Golgi F3L01_RS04225 ENOG4105CUB amino acid F3L01_RS04230 ENOG4107RWR Sodium hydrogen exchanger F3L01_RS04240 ENOG4106KNT transcriptional regulator F3L01_RS04245 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate F3L01_RS04280 ENOG4108YXU transcriptional regulator AsnC family F3L01_RS04285 ENOG4105CH7 arginosuccinase F3L01_RS04290 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F3L01_RS04330 ENOG4105NF4 modulator of drug activity F3L01_RS04335 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) F3L01_RS04340 ENOG4105E5W Transporter F3L01_RS04355 ENOG4107RKG DJ-1/PfpI family F3L01_RS04360 ENOG4105CH6 catalase F3L01_RS04375 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) F3L01_RS04385 ENOG4105C26 Dehydrogenase F3L01_RS04390 ENOG4105BZ1 (ABC) transporter F3L01_RS04395 ENOG4105BZ1 (ABC) transporter F3L01_RS04405 ENOG4105DRP amino acid AbC transporter F3L01_RS04410 ENOG4105CDA abc transporter atp-binding protein F3L01_RS04425 ENOG410839P F3L01_RS04445 ENOG4105BZU Histidine kinase F3L01_RS04450 ENOG4105WH1 Two component transcriptional regulator luxr family F3L01_RS04460 ENOG4107FQX Alpha-acetolactate decarboxylase F3L01_RS04465 ENOG4108VX5 3-methyladenine DNA glycosylase F3L01_RS04480 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase F3L01_RS04485 ENOG4105D4P Coproporphyrinogen iii oxidase F3L01_RS04490 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_RS04505 ENOG4105CHH sulfate transporter F3L01_RS04530 ENOG4105CGU Enoyl-CoA hydratase F3L01_RS04550 ENOG4105DER m42 family F3L01_RS04570 ENOG4105CTU Proline racemase F3L01_RS04575 ENOG4105CIF Ornithine Cyclodeaminase F3L01_RS04590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L01_RS04600 ENOG4108JQ7 (ABC) transporter F3L01_RS04660 ENOG4108IBT Inherit from COG: transposase F3L01_RS04725 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) F3L01_RS04800 ENOG4105CSH Transporter F3L01_RS04810 ENOG4108MRH transcriptional regulatory protein F3L01_RS04870 ENOG4105CDU Replicative dna helicase F3L01_RS04905 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L01_RS04920 ENOG4105D9U N-acetyltransferase F3L01_RS04940 ENOG4105F6J Alpha beta hydrolase fold F3L01_RS04970 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase F3L01_RS04985 ENOG4105CMT Dihydroxyacetone kinase F3L01_RS04995 ENOG4105CMT Dihydroxyacetone kinase F3L01_RS05045 ENOG4108WC5 Alpha Beta Hydrolase Fold protein F3L01_RS05085 ENOG4105WN5 stage II sporulation protein F3L01_RS05095 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_RS05105 ENOG4108MJI response regulator F3L01_RS05110 ENOG4105BZU Histidine kinase F3L01_RS05115 ENOG4105BZU Histidine kinase F3L01_RS05160 ENOG4107QHE Choloylglycine hydrolase F3L01_RS05180 ENOG4107VRP DNA repair exonuclease F3L01_RS05185 ENOG4106D4I domain protein F3L01_RS05215 ENOG4108MUZ hydrolase F3L01_RS05240 ENOG4105F0F Oxalate decarboxylase F3L01_RS05245 ENOG41067QW Transcriptional regulator F3L01_RS05250 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator F3L01_RS05265 ENOG4105C6V Glycerol-3-phosphate dehydrogenase F3L01_RS05285 ENOG4105DU6 RNA polymerase F3L01_RS05310 ENOG4105EEM helicase F3L01_RS05320 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) F3L01_RS05345 ENOG4105K59 histidine triad (HIT) protein F3L01_RS05380 ENOG410905X membrane-flanked domain protein F3L01_RS05385 ENOG4105CKV Membrane F3L01_RS05420 ENOG410905X membrane-flanked domain protein F3L01_RS05425 ENOG4105CKV Membrane F3L01_RS05430 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation F3L01_RS05435 ENOG4105BZ4 penicillin-binding protein F3L01_RS05445 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) F3L01_RS05450 ENOG4105C1Q protoporphyrinogen oxidase F3L01_RS05475 ENOG4105NA0 Transcriptional regulator F3L01_RS05490 ENOG4105ECB domain protein F3L01_RS05510 ENOG4108MK9 spermidine N(1)-acetyltransferase F3L01_RS05520 ENOG4106AXD F3L01_RS05525 ENOG4108RQ5 Beta-lactamase domain-containing protein F3L01_RS05530 ENOG4105DF9 Lipoate-protein, ligase F3L01_RS05540 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_RS05550 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein F3L01_RS05555 ENOG4108I5D sulfate abc transporter F3L01_RS05560 ENOG4105ECW sulfate abc transporter F3L01_RS05565 ENOG4108IJ6 ABC transporter F3L01_RS05635 ENOG4107RN3 metallophosphoesterase F3L01_RS05640 ENOG4107TVP HD domain protein F3L01_RS05650 ENOG4108AEY RNA polymerase sigma factor F3L01_RS05655 ENOG41086D8 Transcriptional regulator F3L01_RS05670 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_RS05685 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 F3L01_RS05690 ENOG4105C8Q Methyl-accepting chemotaxis F3L01_RS05695 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) F3L01_RS05705 ENOG4107QP3 malate synthase g F3L01_RS05760 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation F3L01_RS05765 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F3L01_RS05805 ENOG4105ERH Fumarylacetoacetate hydrolase F3L01_RS05815 ENOG4105C8Y Acetylornithine aminotransferase F3L01_RS05835 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) F3L01_RS05840 ENOG4105CH6 catalase F3L01_RS05845 ENOG4105BZU Histidine kinase F3L01_RS05865 ENOG4105QNR S1 RNA binding domain protein F3L01_RS05870 ENOG4105CNA YD repeat protein F3L01_RS05880 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) F3L01_RS05890 ENOG4107AYK membrAne F3L01_RS05895 ENOG41073B9 F3L01_RS05905 ENOG4108KP7 hydrolase F3L01_RS05915 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F3L01_RS05940 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) F3L01_RS05945 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F3L01_RS05960 ENOG4105C31 Tryptophanyl-tRNA synthetase F3L01_RS05975 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F3L01_RS05980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L01_RS05990 ENOG4108JQ7 (ABC) transporter F3L01_RS05995 ENOG4105UQX Mate efflux family protein F3L01_RS06015 ENOG4108ZCF integral membrane protein F3L01_RS06025 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F3L01_RS06035 ENOG4105DPN Oligoendopeptidase f F3L01_RS06050 ENOG4108Z18 K06886 hemoglobin F3L01_RS06055 ENOG4105MIX Adenylate cyclase F3L01_RS06070 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) F3L01_RS06075 ENOG4105EMS pseudouridine synthase F3L01_RS06095 ENOG4105K64 Glycosyl transferase, family 2 F3L01_RS06115 ENOG4107TVC Glycosyl transferase, family 2 F3L01_RS06135 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) F3L01_RS06140 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase F3L01_RS06150 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase F3L01_RS06225 ENOG4105CK7 Sodium proline symporter F3L01_RS06235 ENOG4105DDQ anthranilate synthase F3L01_RS06245 ENOG4105DK0 Indole-3-glycerol phosphate synthase F3L01_RS06250 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase F3L01_RS06255 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) F3L01_RS06260 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) F3L01_RS06325 ENOG4105C7S Dehydrogenase F3L01_RS06360 ENOG4108IUX (ABC) transporter F3L01_RS06365 ENOG4105RHA ABC transporter, permease F3L01_RS06395 ENOG4105DZ1 carboxypeptidase F3L01_RS06400 ENOG4105VFR signal peptidase F3L01_RS06435 ENOG4105C26 Dehydrogenase F3L01_RS06440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F3L01_RS06445 ENOG4105F38 ABC transporter, permease F3L01_RS06450 ENOG4105D38 putrescine abc transporter F3L01_RS06455 ENOG4108HM4 ABC transporter F3L01_RS06465 ENOG4105EYF MMPL domain protein F3L01_RS06475 ENOG4108YBP pseudouridine synthase F3L01_RS06485 ENOG4105K4I Scp-like extracellular F3L01_RS06490 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) F3L01_RS06495 ENOG4105CQB FAD linked oxidase domain protein F3L01_RS06510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_RS06515 ENOG4105BZU Histidine kinase F3L01_RS06520 ENOG4105JXH GntR family transcriptional regulator F3L01_RS06540 ENOG4106A3R peptidase F3L01_RS06550 ENOG4108QTI )-transporter F3L01_RS06555 ENOG4107TS3 membrane protein, TerC F3L01_RS06560 ENOG4105CZN Potassium uptake protein F3L01_RS06565 ENOG410681C small acid-soluble spore protein F3L01_RS06570 ENOG4108Z7G MaoC domain protein dehydratase F3L01_RS06590 ENOG4105CHR reductase F3L01_RS06620 ENOG4105C4Y ABC transporter F3L01_RS06625 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F3L01_RS06630 ENOG4107RCV ABC transporter, permease F3L01_RS06650 ENOG4105E98 transcriptional regulator DeoR family F3L01_RS06660 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) F3L01_RS06670 ENOG4105PXI polysaccharide deacetylase F3L01_RS06680 ENOG4105BZU Histidine kinase F3L01_RS06685 ENOG41090MY MarR family Transcriptional regulator F3L01_RS06695 ENOG4106DF1 F3L01_RS06700 ENOG4105BZU Histidine kinase F3L01_RS06705 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) F3L01_RS06710 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase F3L01_RS06715 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) F3L01_RS06755 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) F3L01_RS06760 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F3L01_RS06765 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F3L01_RS06770 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family F3L01_RS06775 ENOG4105CZV ABC transporter F3L01_RS06785 ENOG4105CJ1 ABC, transporter F3L01_RS06825 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A F3L01_RS06830 ENOG4105EA8 2-Nitropropane dioxygenase F3L01_RS06835 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD F3L01_RS06845 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein F3L01_RS06870 ENOG4105NQC Flavodoxin F3L01_RS06910 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) F3L01_RS06940 ENOG4105CZN Potassium uptake protein F3L01_RS06945 ENOG41063Y9 F3L01_RS06950 ENOG4105KBJ sporulation protein ytfj F3L01_RS06970 ENOG4105CM2 brancheD-chain amino acid aminotransferase F3L01_RS06975 ENOG4105C7K acetolactate synthase F3L01_RS06980 ENOG4108ZP8 Acetolactate synthase small subunit F3L01_RS06985 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase F3L01_RS07000 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) F3L01_RS07015 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) F3L01_RS07020 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) F3L01_RS07025 ENOG4105ECC imidazole-glycerol-phosphate dehydratase F3L01_RS07030 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) F3L01_RS07035 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase F3L01_RS07040 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) F3L01_RS07050 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase F3L01_RS07070 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase F3L01_RS07075 ENOG4105E0M Sulfatase F3L01_RS07085 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) F3L01_RS07105 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) F3L01_RS07110 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) F3L01_RS07120 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F3L01_RS07125 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein F3L01_RS07130 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein F3L01_RS07135 ENOG4105C8J )-transporter F3L01_RS07160 ENOG4105DFD Na H antiporter F3L01_RS07180 ENOG4105ENE Histidine kinase F3L01_RS07185 ENOG4105WH1 Two component transcriptional regulator luxr family F3L01_RS07205 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F3L01_RS07230 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F3L01_RS07250 ENOG4105CJ3 phosphate transporter F3L01_RS07255 ENOG4107GRR phosphate transport regulator F3L01_RS07260 ENOG4105BZ4 penicillin-binding protein F3L01_RS07275 ENOG4105BZU Histidine kinase F3L01_RS07280 ENOG4105I3N Conserved Protein F3L01_RS07295 ENOG4105BZU Histidine kinase F3L01_RS07300 ENOG4105D3A purine nucleoside phosphorylase DeoD-type F3L01_RS07325 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F3L01_RS07330 ENOG4105DZ1 carboxypeptidase F3L01_RS07335 ENOG4108JIC nucleoside recognition domain protein F3L01_RS07345 ENOG4105FE9 pseudouridine synthase F3L01_RS07350 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F3L01_RS07355 ENOG4107TWT Cytochrome c biogenesis protein F3L01_RS07360 ENOG4105CRE cytochrome C F3L01_RS07365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_RS07370 ENOG4105BZU Histidine kinase F3L01_RS07375 ENOG4108WBT adenosyltransferase F3L01_RS07390 ENOG4108SAX Membrane F3L01_RS07405 ENOG4105C9U ATP-dependent DNA helicase RecQ F3L01_RS07410 ENOG4105I7S Abortive infection protein F3L01_RS07420 ENOG4107RGJ metallophosphoesterase F3L01_RS07425 ENOG4108XDN Transcriptional regulator F3L01_RS07430 ENOG4108S6Z Negative regulator of genetic competence F3L01_RS07455 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase F3L01_RS07460 ENOG4107RB3 L-asparaginase F3L01_RS07480 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) F3L01_RS07495 ENOG4105S2F F3L01_RS07500 ENOG41065D1 F3L01_RS07530 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) F3L01_RS07545 ENOG4105XXQ heptaprenyl diphosphate synthase component I F3L01_RS07555 ENOG4105EAH synthase F3L01_RS07560 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) F3L01_RS07565 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase F3L01_RS07570 ENOG4105D49 3-dehydroquinate synthase F3L01_RS07580 ENOG41068YB TPR repeat-containing protein F3L01_RS07595 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) F3L01_RS07600 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) F3L01_RS07635 ENOG4108JYZ YitT family F3L01_RS07640 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase F3L01_RS07645 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) F3L01_RS07655 ENOG4105FJR Lmbe family F3L01_RS07660 ENOG4105CPK Glycosyl transferase (Group 1 F3L01_RS07680 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) F3L01_RS07695 ENOG4105DVT helicase F3L01_RS07700 ENOG4105YAC F3L01_RS07720 ENOG4105CSM endonuclease III F3L01_RS07730 ENOG4105BZ4 penicillin-binding protein F3L01_RS07770 ENOG4106F55 Protein of unknown function (DUF1273) F3L01_RS07785 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) F3L01_RS07825 ENOG4105DVT helicase F3L01_RS07830 ENOG4105CTD carboxy-peptidase F3L01_RS07840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F3L01_RS07850 ENOG4105C2W permease F3L01_RS07855 ENOG4105DHF Membrane F3L01_RS07860 ENOG410890F Dynamin family F3L01_RS07870 ENOG4108W0I acetyltransferase F3L01_RS07880 ENOG4105KHC sulfurtransferase F3L01_RS07935 ENOG4105HTX biosynthesis protein F3L01_RS07965 ENOG4105CPK Glycosyl transferase (Group 1 F3L01_RS07980 ENOG4108SZE gCN5-related N-acetyltransferase F3L01_RS08000 ENOG41081VK Ribonuclease F3L01_RS08065 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F3L01_RS08075 ENOG4107RWR Sodium hydrogen exchanger F3L01_RS08080 ENOG4105CN5 Metallo-Beta-Lactamase F3L01_RS08085 ENOG4108Z5V transcriptional regulator, merr family F3L01_RS08095 ENOG4105H67 Protein of unknown function (DUF421) F3L01_RS08100 ENOG41080C8 DUF218 domain F3L01_RS08135 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) F3L01_RS08145 ENOG4107R0U MotA TolQ exbB proton channel F3L01_RS08150 ENOG4105ER2 Ompa motb domain protein F3L01_RS08155 ENOG4107YTP response regulator receiver protein F3L01_RS08160 ENOG4105CBS Chea signal transduction histidine kinase F3L01_RS08165 ENOG4105DD5 Flagellar motor switch protein F3L01_RS08180 ENOG4105BZU Histidine kinase F3L01_RS08200 ENOG4105E1Q flagellar hook-associated protein F3L01_RS08205 ENOG4105DTJ flagellar hook-associated protein F3L01_RS08210 ENOG4107TPX flagellar hook-associated F3L01_RS08225 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) F3L01_RS08230 ENOG4108ZC9 flagellar basal-body rod protein flgc F3L01_RS08245 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F3L01_RS08275 ENOG4105BZE flagellar hook protein, FlgE F3L01_RS08290 ENOG4107R88 Chemotaxis protein (CheV) F3L01_RS08300 ENOG4105I03 Flagellin F3L01_RS08305 ENOG4105I03 Flagellin F3L01_RS08310 ENOG4105I03 Flagellin F3L01_RS08315 ENOG4105I03 Flagellin F3L01_RS08320 ENOG4105I03 Flagellin F3L01_RS08325 ENOG4105E4C Lytic transglycosylase catalytic F3L01_RS08335 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F3L01_RS08340 ENOG4105DD5 Flagellar motor switch protein F3L01_RS08350 ENOG4105CN7 Flagellar biosynthetic protein FliP F3L01_RS08355 ENOG4105VS8 Flagellar biosynthetic protein fliq F3L01_RS08365 ENOG4105D00 flagellar biosynthetic protein flhB F3L01_RS08370 ENOG4105D7B Flagellar biosynthesis protein flha F3L01_RS08380 ENOG4105FZW flagellar biosynthesis regulator FlhF F3L01_RS08385 ENOG4105KTQ flagellar basal-body rod protein F3L01_RS08390 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F3L01_RS08425 ENOG4105KAC Antibiotic biosynthesis monooxygenase F3L01_RS08500 ENOG4105CVJ phosphoglycerate mutase F3L01_RS08510 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) F3L01_RS08530 ENOG4105CAQ asparagine synthetase F3L01_RS08550 ENOG4105PGM cation diffusion facilitator family transporter F3L01_RS08560 ENOG4105DRR Transcriptional regulator, GntR family F3L01_RS08575 ENOG4105CKI cobalamin synthesis protein F3L01_RS08580 ENOG4108PJD permease F3L01_RS08595 ENOG4105DFD Na H antiporter F3L01_RS08600 ENOG4105VUF Transcriptional regulator F3L01_RS08610 ENOG4105C9Q fumarate hydratase class II F3L01_RS08625 ENOG4107QJQ Mate efflux family protein F3L01_RS08630 ENOG4105EC3 peptidase S51, dipeptidase E F3L01_RS08655 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F3L01_RS08670 ENOG4107JM4 Tetratricopeptide repeat F3L01_RS08685 ENOG4105BZC d-serine deaminase F3L01_RS08690 ENOG4106BRA Membrane F3L01_RS08725 ENOG4105CJ1 ABC, transporter F3L01_RS08745 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) F3L01_RS08760 ENOG4108IJ0 Aspartate ammonia-lyase F3L01_RS08765 ENOG4105C6K Malic enzyme F3L01_RS08815 ENOG4105FVX F3L01_RS08820 ENOG4105E09 nadh pyrophosphatase F3L01_RS08835 ENOG4105CSR polyphosphate kinase 2 F3L01_RS08840 ENOG4105U3E Transcriptional regulator F3L01_RS08855 ENOG4105DXI Major Facilitator superfamily F3L01_RS08865 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F3L01_RS08870 ENOG4105EU0 Major facilitator Superfamily F3L01_RS08875 ENOG4105C6T cysteine synthase F3L01_RS08895 ENOG4105C8J )-transporter F3L01_RS08905 ENOG4105X5K response regulator receiver protein F3L01_RS08910 ENOG4105H67 Protein of unknown function (DUF421) F3L01_RS08930 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) F3L01_RS08935 ENOG4105CHR reductase F3L01_RS08940 ENOG4105CM2 brancheD-chain amino acid aminotransferase F3L01_RS08945 ENOG4105C7K acetolactate synthase F3L01_RS08955 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase F3L01_RS08960 ENOG4105C01 Dihydroxy-acid dehydratase F3L01_RS08965 ENOG4105C7B Threonine dehydratase F3L01_RS08995 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b F3L01_RS09005 ENOG4105DY9 regulatoR F3L01_RS09010 ENOG4105CYC Transferase F3L01_RS09025 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) F3L01_RS09055 ENOG41068WN F3L01_RS09075 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) F3L01_RS09090 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) F3L01_RS09095 ENOG4105C0X amino acid F3L01_RS09120 ENOG4105K8R UPF0145 protein F3L01_RS09135 ENOG4107RHR regulatoR F3L01_RS09145 ENOG4105D9N nucleoside F3L01_RS09150 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) F3L01_RS09195 ENOG4107RAQ aminopeptidase F3L01_RS09205 ENOG4107R16 Multicopper oxidase F3L01_RS09245 ENOG4108T5E Copper resistance protein F3L01_RS09250 ENOG4105KTB nuclear export factor GLE1 F3L01_RS09255 ENOG4107RT3 EamA-like transporter family F3L01_RS09260 ENOG4105GZI Transcriptional regulator F3L01_RS09265 ENOG4108Z40 Transcriptional regulator F3L01_RS09270 ENOG4107ZXU DSBA oxidoreductase F3L01_RS09275 ENOG4108TVJ Nitroreductase F3L01_RS09280 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) F3L01_RS09285 ENOG4106F5Q Membrane F3L01_RS09290 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F3L01_RS09300 ENOG4105CKI cobalamin synthesis protein F3L01_RS09310 ENOG4105C0Z ABC transporter F3L01_RS09315 ENOG4108IV0 ABC, transporter F3L01_RS09320 ENOG4105C32 Amino acid ABC transporter (Permease) F3L01_RS09330 ENOG4105SKE transcriptional Regulator LysR family F3L01_RS09350 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes F3L01_RS09360 ENOG4105C4M (Ubiquinol oxidase) subunit I F3L01_RS09365 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F3L01_RS09370 ENOG4108JJ9 ABC, transporter F3L01_RS09375 ENOG4108JJ8 (ABC) transporter F3L01_RS09385 ENOG4105K64 Glycosyl transferase, family 2 F3L01_RS09395 ENOG4108UT6 Transferase hexapeptide repeat containing protein F3L01_RS09450 ENOG4105BZ1 (ABC) transporter F3L01_RS09455 ENOG4105EFI regulatoR F3L01_RS09460 ENOG4105BZU Histidine kinase F3L01_RS09475 ENOG41075D4 Aminoglycoside 6-adenylyltransferase F3L01_RS09500 ENOG4105D6E homoserine dehydrogenase F3L01_RS09525 ENOG4108KGH TRANSCRIPTIONal F3L01_RS09535 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_RS09540 ENOG4105BZU Histidine kinase F3L01_RS09555 ENOG4105KT7 mgtC SapB transporter F3L01_RS09560 ENOG4105VRR gCN5-related N-acetyltransferase F3L01_RS09570 ENOG4105DUU IucA IucC family protein F3L01_RS09575 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_RS09590 ENOG4108WBH protein TIM barrel F3L01_RS09595 ENOG4105YWU small acid-soluble spore protein F3L01_RS09605 ENOG4108ZUB Lysine exporter protein (Lyse ygga) F3L01_RS09610 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F3L01_RS09660 ENOG4105KRN Transcriptional regulator, abrb family F3L01_RS09670 ENOG4105YVS arsR family transcriptional regulator F3L01_RS09675 ENOG4105CPC Aldo Keto reductase F3L01_RS09680 ENOG4107XZQ multidrug resistance protein F3L01_RS09685 ENOG4105KAF membrAne F3L01_RS09710 ENOG4105C8Q Methyl-accepting chemotaxis F3L01_RS09725 ENOG4108K88 Membrane F3L01_RS09730 ENOG4108WPJ Ferritin-like domain F3L01_RS09745 ENOG4105DEN Luciferase family F3L01_RS09760 ENOG4105VMI -acetyltransferase F3L01_RS09765 ENOG4107QM2 Aldo Keto reductase F3L01_RS09770 ENOG4105CKI cobalamin synthesis protein F3L01_RS09780 ENOG4105DSE periplasmic solute binding protein F3L01_RS09790 ENOG4105K4T epimerase F3L01_RS09800 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F3L01_RS09845 ENOG4107T5V SNARE associated Golgi F3L01_RS09860 ENOG4108PJD permease F3L01_RS09880 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F3L01_RS09900 ENOG4105SXS Protein of unknown function (DUF456) F3L01_RS09905 ENOG4105C37 (CBS) domain F3L01_RS09925 ENOG4108Z7R Chaperone CsaA F3L01_RS09945 ENOG4108ZRV stage ii sporulation protein p F3L01_RS09955 ENOG4108VXD carboxy-peptidase F3L01_RS09965 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) F3L01_RS10015 ENOG4105D6J arsenicaL-resistance protein F3L01_RS10020 ENOG41082YX Transcriptional regulator, arsr family F3L01_RS10090 ENOG4108ZRV stage ii sporulation protein p F3L01_RS10100 ENOG4108X4Q Hydrolase F3L01_RS10115 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F3L01_RS10130 ENOG41087PP glycosyltransferase MGT family F3L01_RS10135 ENOG4108JYZ YitT family F3L01_RS10140 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F3L01_RS10170 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) F3L01_RS10205 ENOG4108MGT Required for secretion of EsxA and EsxB F3L01_RS10280 ENOG4105KBJ sporulation protein ytfj F3L01_RS10305 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F3L01_RS10325 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) F3L01_RS10330 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily F3L01_RS10340 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein F3L01_RS10345 ENOG4105EMN RNA polymerase sigma factor F3L01_RS10355 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) F3L01_RS10365 ENOG4105CNW domain protein F3L01_RS10375 ENOG4108V06 Glutathione peroxidase F3L01_RS10400 ENOG4108IUE nitrate reductase beta subunit F3L01_RS10405 ENOG4105R3A Nitrate reductase F3L01_RS10415 ENOG4107V6Q Cyclic nucleotide-binding domain F3L01_RS10420 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F3L01_RS10425 ENOG4105D06 uba thif-type nad fad binding protein F3L01_RS10430 ENOG4105CVM Molybdenum cofactor synthesis domain protein F3L01_RS10435 ENOG4108ZAF Molybdopterin F3L01_RS10465 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein F3L01_RS10470 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein F3L01_RS10475 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F3L01_RS10480 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit F3L01_RS10485 ENOG4108IFG nitrite reductase, (NAD(P)H) F3L01_RS10490 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) F3L01_RS10525 ENOG4105MCT stage V sporulation protein S F3L01_RS10585 ENOG4108UUM single-stranded DNA-binding protein F3L01_RS10605 ENOG4107YX5 Pfam:DUF548 F3L01_RS10610 ENOG4105C75 arginyL-tRNA synthetase F3L01_RS10635 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) F3L01_RS10650 ENOG4105C5S asparaginyl-tRNA synthetase F3L01_RS10655 ENOG4105C8J )-transporter F3L01_RS10675 ENOG4107XGZ Hydrolase F3L01_RS10680 ENOG4105CY2 Citrate transporter F3L01_RS10700 ENOG4105KD7 acetyltransferase F3L01_RS10710 ENOG4105VMP Transcriptional regulator F3L01_RS10715 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase F3L01_RS10740 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 F3L01_RS10755 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) F3L01_RS10765 ENOG4105EKQ RNA-directed DNA polymerase F3L01_RS10780 ENOG4107RVG penicillin-binding protein F3L01_RS10785 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) F3L01_RS10790 ENOG4105E9Q Acyl-transferase F3L01_RS10795 ENOG4108UT2 hemolysin iii F3L01_RS10805 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) F3L01_RS10815 ENOG4108RCR degv family F3L01_RS10825 ENOG4108KF3 Electron transport protein SCO1 SenC F3L01_RS10830 ENOG4107Y70 Heat shock protein F3L01_RS10835 ENOG4105CAQ asparagine synthetase F3L01_RS10860 ENOG4105F0I Aminotransferase F3L01_RS10890 ENOG4105D8X mechanosensitive ion channel F3L01_RS10895 ENOG4105BZU Histidine kinase F3L01_RS10905 ENOG4106KNT transcriptional regulator F3L01_RS10980 ENOG4105E90 ABC transporter F3L01_RS11015 ENOG4105C37 (CBS) domain F3L01_RS11040 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F3L01_RS11055 ENOG4107S4Y M20 DapE family protein YgeY F3L01_RS11060 ENOG4108TSC N-acetyltransferase F3L01_RS11065 ENOG4108JUB Transcriptional regulator F3L01_RS11070 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein F3L01_RS11115 ENOG410841Q phosphoesterase PA-phosphatase related protein F3L01_RS11125 ENOG4105SZ6 Thioredoxin F3L01_RS11230 ENOG4105BZ4 penicillin-binding protein F3L01_RS11240 ENOG4105CZM Major Facilitator F3L01_RS11245 ENOG4105W8X HesB YadR YfhF-family protein F3L01_RS11255 ENOG4105DXD 2-methylcitrate dehydratase F3L01_RS11260 ENOG4105CR4 methylisocitrate lyase F3L01_RS11265 ENOG4105C1G acyl-Coa dehydrogenase F3L01_RS11270 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F3L01_RS11280 ENOG4105N14 lysine exporter protein LysE YggA F3L01_RS11285 ENOG4105E39 Enoyl-CoA hydratase F3L01_RS11300 ENOG4107RFY SbcCD D subunit F3L01_RS11305 ENOG4105EYH Exonuclease F3L01_RS11330 ENOG4105FCD Major Facilitator F3L01_RS11335 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase F3L01_RS11340 ENOG4105E4F Isochorismate synthase F3L01_RS11345 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase F3L01_RS11350 ENOG4105WQI isochorismatase F3L01_RS11355 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_RS11360 ENOG4105WQT MbtH domain protein F3L01_RS11365 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L01_RS11380 ENOG4105K70 DNA-binding protein F3L01_RS11400 ENOG4105BZG amino acid carrier protein F3L01_RS11420 ENOG4105FE9 pseudouridine synthase F3L01_RS11430 ENOG4105C19 ABC transporter F3L01_RS11485 ENOG41081I9 integral membrane protein F3L01_RS11515 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) F3L01_RS11525 ENOG4105EYF MMPL domain protein F3L01_RS11580 ENOG4105C1Q protoporphyrinogen oxidase F3L01_RS11590 ENOG41068WN F3L01_RS11650 ENOG4108RPX mosc domain containing protein F3L01_RS11670 ENOG4105BZ1 (ABC) transporter F3L01_RS11700 ENOG4108JCI Transcriptional regulator F3L01_RS11730 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) F3L01_RS11735 ENOG4108KPJ rna polymerase sigma factor F3L01_RS11760 ENOG4105F32 YngK protein F3L01_RS11780 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) F3L01_RS11785 ENOG4105RD7 BadF BadG BcrA BcrD F3L01_RS11790 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) F3L01_RS11795 ENOG4107STF Involved in phosphonate degradation (By similarity) F3L01_RS11805 ENOG4108INS Transcriptional regulator F3L01_RS11825 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) F3L01_RS11835 ENOG4105C1J atp-dependent rna helicase F3L01_RS11845 ENOG4108RZE Tetr family transcriptional regulator F3L01_RS11950 ENOG41088CC tellurite resistance protein tehB F3L01_RS11960 ENOG4108I0C methyltransferase F3L01_RS11965 ENOG4107RA9 decarboxylase F3L01_RS11970 ENOG4105K56 Transcriptional regulator F3L01_RS11975 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F3L01_RS12000 ENOG4105CIN aminoacyl-histidine dipeptidase F3L01_RS12025 ENOG4105KRN Transcriptional regulator, abrb family F3L01_RS12035 ENOG4105EJ9 Membrane F3L01_RS12040 ENOG4105EQK -acetyltransferase F3L01_RS12210 ENOG4107RF6 penicillin-binding protein F3L01_RS12225 ENOG4105DIN metallophosphoesterase F3L01_RS12235 ENOG4105CJ1 ABC, transporter F3L01_RS12245 ENOG4107Z3H Transcriptional regulator, TetR family F3L01_RS12260 ENOG4105C1G acyl-Coa dehydrogenase F3L01_RS12265 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F3L01_RS12270 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit F3L01_RS12275 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase F3L01_RS12280 ENOG4105E39 Enoyl-CoA hydratase F3L01_RS12285 ENOG4107QX3 carboxylase F3L01_RS12290 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F3L01_RS12335 ENOG4105DZ1 carboxypeptidase F3L01_RS12350 ENOG4105T9C HD domain F3L01_RS12360 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) F3L01_RS12380 ENOG41075H3 AraC family transcriptional regulator F3L01_RS12410 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F3L01_RS12440 ENOG4105MDS 4-oxalocrotonate tautomerase F3L01_RS12445 ENOG4107V2S Transcriptional regulator F3L01_RS12480 ENOG4105EFA 4-hydroxyphenylacetate F3L01_RS12495 ENOG4105CPQ Dehydrogenase F3L01_RS12505 ENOG410900G Protein of unknown function (DUF421) F3L01_RS12510 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) F3L01_RS12520 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein F3L01_RS12530 ENOG4105DK7 lysyl-tRNA synthetase F3L01_RS12540 ENOG4108VQT Alpha beta hydrolase fold protein F3L01_RS12600 ENOG4105D6E homoserine dehydrogenase F3L01_RS12610 ENOG4105CPF Cell wall formation (By similarity) F3L01_RS12615 ENOG4105ETU transcriptional activator (TenA F3L01_RS12705 ENOG410667J hydrolase F3L01_RS12710 ENOG4105BZU Histidine kinase F3L01_RS12715 ENOG4107RF6 penicillin-binding protein F3L01_RS12740 ENOG4108FPN Integrase F3L01_RS12760 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) F3L01_RS12775 ENOG41086D8 Transcriptional regulator F3L01_RS12800 ENOG4108NHD germination protein F3L01_RS12810 ENOG4108W2Y isochorismatase F3L01_RS12830 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) F3L01_RS12840 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F3L01_RS12885 ENOG4108JJB ABC transporter F3L01_RS12900 ENOG4108HGU Histidine kinase F3L01_RS12915 ENOG4105CB2 alcohol dehydrogenase F3L01_RS12920 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase F3L01_RS12925 ENOG4105CJN penicillin-binding protein F3L01_RS12980 ENOG4107Y80 Major Facilitator superfamily F3L01_RS12995 ENOG4107VXM glycerophosphoryl diester phosphodiesterase F3L01_RS13020 ENOG4107Y9U Membrane F3L01_RS13065 ENOG4105FCD Major Facilitator F3L01_RS13080 ENOG4105E09 nadh pyrophosphatase F3L01_RS13085 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F3L01_RS13105 ENOG4105KME endoribonuclease L-psp F3L01_RS13110 ENOG4108XI2 Domain of unknown function (DUF1963) F3L01_RS13130 ENOG4108NRW Phospholipase, patatin family F3L01_RS13135 ENOG4105KWG Pfam:DUF1696 F3L01_RS13160 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) F3L01_RS13170 ENOG4105PKS Excinuclease abc c subunit domain protein F3L01_RS13200 ENOG4105CJ1 ABC, transporter F3L01_RS13220 ENOG4107VFR oxidoreductase F3L01_RS13275 ENOG4108IUM Glycogen debranching enzyme F3L01_RS13285 ENOG4105CGH 5'-nucleotidase F3L01_RS13300 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F3L01_RS13305 ENOG4105FDR Membrane F3L01_RS13315 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) F3L01_RS13390 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) F3L01_RS13395 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) F3L01_RS13400 ENOG4107Z3H Transcriptional regulator, TetR family F3L01_RS13420 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family F3L01_RS13435 ENOG4105E98 transcriptional regulator DeoR family F3L01_RS13450 ENOG41062ES Transcriptional regulator F3L01_RS13470 ENOG4107QKR Dehydrogenase F3L01_RS13480 ENOG4107RUY (E1 component), alpha subunit F3L01_RS13495 ENOG4105E1F short-chain dehydrogenase reductase F3L01_RS13525 ENOG4107SQ8 Glycine betaine F3L01_RS13530 ENOG4108IJ7 Glycine betaine F3L01_RS13540 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F3L01_RS13560 ENOG41082BV acetyltransferase F3L01_RS13565 ENOG4108M1A Chitin-binding protein F3L01_RS13595 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F3L01_RS13600 ENOG4105MSB protein, conserved in bacteria F3L01_RS13625 ENOG4108Z7F N-acetyltransferase F3L01_RS13645 ENOG4105EEM helicase F3L01_RS13670 ENOG4105C9U ATP-dependent DNA helicase RecQ F3L01_RS13720 ENOG4108M1A Chitin-binding protein F3L01_RS13740 ENOG4105BZG amino acid carrier protein F3L01_RS13750 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F3L01_RS13755 ENOG4105CTU Proline racemase F3L01_RS13760 ENOG4105CTU Proline racemase F3L01_RS13765 ENOG41080HI glycine oxidase F3L01_RS13775 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein F3L01_RS13805 ENOG4105DCI Phosphohydrolase F3L01_RS13810 ENOG4107T5V SNARE associated Golgi F3L01_RS13840 ENOG4105DTQ mandelate racemase muconate lactonizing F3L01_RS13855 ENOG4107SET aldo keto reductase F3L01_RS13890 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) F3L01_RS13895 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) F3L01_RS13900 ENOG4105BZU Histidine kinase F3L01_RS13905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_RS13930 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 F3L01_RS13950 ENOG4105EPR degv family F3L01_RS14010 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) F3L01_RS14015 ENOG4106K7D Major facilitator family transporter F3L01_RS14035 ENOG4107BMA Transglycosylase associated protein F3L01_RS14050 ENOG41089UC methyltransferase, type 11 F3L01_RS14085 ENOG4105CHM Aminotransferase F3L01_RS14100 ENOG4108ZMI UPF0477 protein F3L01_RS14140 ENOG4105C02 permease F3L01_RS14150 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) F3L01_RS14155 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component F3L01_RS14160 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein F3L01_RS14165 ENOG4105D7T ABC transporter F3L01_RS14200 ENOG4108AQF aminoglycoside N(3)-acetyltransferase F3L01_RS14235 ENOG4107VC0 DNA alkylation repair enzyme F3L01_RS14240 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase F3L01_RS14260 ENOG4108ZCF integral membrane protein F3L01_RS14265 ENOG4105E0M Sulfatase F3L01_RS14270 ENOG4105C5H ABC transporter F3L01_RS14345 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F3L01_RS14355 ENOG4105EYF MMPL domain protein F3L01_RS14360 ENOG41082JN Transcriptional regulator F3L01_RS14380 ENOG4105CIH Imidazole acetol-phosphate transaminase F3L01_RS14385 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase F3L01_RS14390 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase F3L01_RS14410 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) F3L01_RS14435 ENOG41069ER domain protein F3L01_RS14445 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase F3L01_RS14450 ENOG4105DNP FAD linked oxidase domain protein F3L01_RS14475 ENOG4105D4B ABC, transporter F3L01_RS14480 ENOG4105F5R ABC transporter F3L01_RS14485 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane F3L01_RS14495 ENOG4105DKT Transcriptional regulator F3L01_RS14500 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) F3L01_RS14510 ENOG41061GT Aldolase F3L01_RS14525 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) F3L01_RS14560 ENOG4105II7 pyrroline-5-carboxylate reductase F3L01_RS14570 ENOG4107258 Transcriptional regulator F3L01_RS14585 ENOG4105ECK Fatty Acid Desaturase F3L01_RS14595 ENOG4107RBI VanW family F3L01_RS14600 ENOG4105G6Z alkaline phosphatase F3L01_RS14610 ENOG4105VMP Transcriptional regulator F3L01_RS14630 ENOG41068WN F3L01_RS14655 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F3L01_RS14670 ENOG4105CSH Transporter F3L01_RS14680 ENOG4105CKK Glycosyl transferase, family 2 F3L01_RS14715 ENOG4105C8Y Acetylornithine aminotransferase F3L01_RS14760 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F3L01_RS14855 ENOG4108TVJ Nitroreductase F3L01_RS14860 ENOG4105FS7 Transcriptional regulator F3L01_RS14875 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F3L01_RS14880 ENOG4105WEC Molybdate metabolism regulator F3L01_RS14885 ENOG4105CMR udp-glucose 4-epimerase F3L01_RS14890 ENOG4105C19 ABC transporter F3L01_RS14915 ENOG4108DMH HTH_ARAC F3L01_RS14920 ENOG4108XET gCN5-related N-acetyltransferase F3L01_RS14995 ENOG410635A Membrane F3L01_RS15005 ENOG4108IQI permease F3L01_RS15015 ENOG4105F1N DNA alkylation repair F3L01_RS15045 ENOG4107RF6 penicillin-binding protein F3L01_RS15075 ENOG4105E7W lamb ycsf family protein F3L01_RS15085 ENOG4105P4J Allophanate hydrolase, subunit 1 F3L01_RS15090 ENOG4107258 Transcriptional regulator F3L01_RS15100 ENOG4106N3A copper homeostasis protein cutc F3L01_RS15105 ENOG4108ZHR arsR family transcriptional regulator F3L01_RS15115 ENOG4105FDT acyl-CoA dehydrogenase F3L01_RS15130 ENOG4105DWD nucleoside recognition domain protein F3L01_RS15175 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) F3L01_RS15200 ENOG4105E2A Dehydrogenase F3L01_RS15210 ENOG4108IJ0 Aspartate ammonia-lyase F3L01_RS15215 ENOG4105HDK L-asparaginase F3L01_RS15220 ENOG4108IMY Transcriptional regulator F3L01_RS15245 ENOG4108B31 Spore germination protein F3L01_RS15255 ENOG4105BZU Histidine kinase F3L01_RS15280 ENOG41075H3 AraC family transcriptional regulator F3L01_RS15290 ENOG4105YWU small acid-soluble spore protein F3L01_RS15300 ENOG4105CUB amino acid F3L01_RS15305 ENOG4105II7 pyrroline-5-carboxylate reductase F3L01_RS15310 ENOG4108NHD germination protein F3L01_RS15315 ENOG4108Q8B Spore germination protein F3L01_RS15375 ENOG4105CGH 5'-nucleotidase F3L01_RS15385 ENOG4105CHJ isochorismatase hydrolase F3L01_RS15410 ENOG41090MY MarR family Transcriptional regulator F3L01_RS15435 ENOG4105F6J Alpha beta hydrolase fold F3L01_RS15455 ENOG4105CVP deoxyribo-dipyrimidine photolyase F3L01_RS15480 ENOG4108TWJ NADH dehydrogenase subunit 5 F3L01_RS15485 ENOG4105GPN Uncharacterized conserved protein (DUF2294) F3L01_RS15500 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase F3L01_RS15525 ENOG4105Z7P Acetyltransferase (GNAT) family F3L01_RS15535 ENOG4105D6J arsenicaL-resistance protein F3L01_RS15540 ENOG41085FC arsR family transcriptional regulator F3L01_RS15550 ENOG4105NAE bifunctional deaminase-reductase domain protein F3L01_RS15555 ENOG4107P5I polyketide synthase F3L01_RS15560 ENOG4108IG5 Transcriptional regulator F3L01_RS15565 ENOG4105CHR reductase F3L01_RS15570 ENOG4108YXU transcriptional regulator AsnC family F3L01_RS15585 ENOG4105D7V transposase F3L01_RS15715 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) F3L01_RS15720 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L01_RS15740 ENOG4105K6H D-cysteine desulfhydrase F3L01_RS15750 ENOG4105E0Y RtcB Protein F3L01_RS15760 ENOG4105JQZ Methyltransferase F3L01_RS15775 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) F3L01_RS15795 ENOG4105BZU Histidine kinase F3L01_RS15805 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) F3L01_RS15835 ENOG4108JQ1 Dehydrogenase F3L01_RS15840 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) F3L01_RS15855 ENOG41082W1 Cupin 2, conserved barrel domain protein F3L01_RS15860 ENOG410874W AraC family transcriptional regulator F3L01_RS15880 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase F3L01_RS16085 ENOG4108VXD carboxy-peptidase F3L01_RS16090 ENOG4105PNM synthesis protein F3L01_RS16100 ENOG4108ISG Major Facilitator F3L01_RS16115 ENOG4107MII Sugar-specific transcriptional regulator TrmB F3L01_RS16120 ENOG4105CZM Major Facilitator F3L01_RS16130 ENOG4105CRW Short chain fatty acid transporter F3L01_RS16140 ENOG4105DYS nad(p)h dehydrogenase (quinone) F3L01_RS16200 ENOG4108K8S endonuclease I F3L01_RS16225 ENOG4108Z66 YbaK ebsC protein F3L01_RS16230 ENOG4105CUT histidyl-tRNA synthetase F3L01_RS16245 ENOG4105KVH Transcriptional regulator F3L01_RS16250 ENOG4108RCM Nitroreductase F3L01_RS16280 ENOG4108PSK reductase F3L01_RS16355 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) F3L01_RS16415 ENOG4105C37 (CBS) domain F3L01_RS16430 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase F3L01_RS16435 ENOG4105FAW cDP-glucose 4,6-dehydratase F3L01_RS16470 ENOG4105DDN Pentapeptide repeat-containing protein F3L01_RS16475 ENOG4105XDF Protein of unknown function (DUF1272) F3L01_RS16480 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) F3L01_RS16485 ENOG4105CMG Carbohydrate kinase F3L01_RS16505 ENOG4105CV1 Transketolase (EC 2.2.1.1) F3L01_RS16510 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase F3L01_RS16515 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase F3L01_RS16520 ENOG4105CIS alcohol dehydrogenase F3L01_RS16525 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone F3L01_RS16540 ENOG4105EWI Short-chain dehydrogenase reductase Sdr F3L01_RS16555 ENOG4105C8Q Methyl-accepting chemotaxis F3L01_RS16560 ENOG4108UX3 '-nucleotidase F3L01_RS16565 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) F3L01_RS16570 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) F3L01_RS16575 ENOG4105KVH Transcriptional regulator F3L01_RS16590 ENOG4105CV8 reductase F3L01_RS16595 ENOG4105F27 Major Facilitator F3L01_RS16605 ENOG41090KN UPF0303 protein F3L01_RS16620 ENOG4105C44 Serine transporter F3L01_RS16650 ENOG4105KVH Transcriptional regulator F3L01_RS16655 ENOG4108TZY GntR Family Transcriptional Regulator F3L01_RS16660 ENOG4105D9R oxidoreductase F3L01_RS16665 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase F3L01_RS16670 ENOG4105KVH Transcriptional regulator F3L01_RS16675 ENOG4105KVH Transcriptional regulator F3L01_RS16715 ENOG4105JAB phenazine biosynthesis protein, phzf family F3L01_RS16725 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein F3L01_RS16730 ENOG4105KVH Transcriptional regulator F3L01_RS16750 ENOG4108ZJ4 polysaccharide deacetylase F3L01_RS16770 ENOG410829K Lysine exporter protein (Lyse ygga) F3L01_RS16830 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) F3L01_RS16840 ENOG4107YXZ hydrolase, family 25 F3L01_RS16870 ENOG4105H3G oxidoreductase F3L01_RS16935 ENOG4108TN2 lmbE family F3L01_RS16945 ENOG4107R3E Citrate transporter F3L01_RS16960 ENOG4108MES Periplasmic binding protein F3L01_RS16965 ENOG4105EHG Permease protein F3L01_RS16970 ENOG4105DQ5 transport system permease protein F3L01_RS16975 ENOG4105NX3 Membrane F3L01_RS16995 ENOG4107CUJ Protein of unknown function (DUF2690) F3L01_RS17005 ENOG4107V2S Transcriptional regulator F3L01_RS17035 ENOG4105E5K Alpha-amylase F3L01_RS17040 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase F3L01_RS17045 ENOG4105DPN Oligoendopeptidase f F3L01_RS17050 ENOG4108A04 Beta-lactamase F3L01_RS17075 ENOG4107VXM glycerophosphoryl diester phosphodiesterase F3L01_RS17085 ENOG41082BM Transcriptional regulator, arsr family F3L01_RS17090 ENOG4105CIS alcohol dehydrogenase F3L01_RS17095 ENOG4105CNG UPF0061 protein F3L01_RS17130 ENOG4105CQB FAD linked oxidase domain protein F3L01_RS17155 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase F3L01_RS17160 ENOG4107TPS domain protein F3L01_RS17165 ENOG4105CEP NADH dehydrogenase F3L01_RS17175 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase F3L01_RS17185 ENOG4108IAJ Nad-dependent epimerase dehydratase F3L01_RS17190 ENOG4105FAW cDP-glucose 4,6-dehydratase F3L01_RS17240 ENOG4105BZU Histidine kinase F3L01_RS17245 ENOG4105C5H ABC transporter F3L01_RS17255 ENOG4107DUR UPF0457 protein F3L01_RS17275 ENOG4105BZU Histidine kinase F3L01_RS17285 ENOG4105KT7 mgtC SapB transporter F3L01_RS17295 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase F3L01_RS17300 ENOG41073R8 VanW family F3L01_RS17310 ENOG4108R1P F3L01_RS17325 ENOG4105VEQ Cold shock protein F3L01_RS17345 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F3L01_RS17365 ENOG410904N short-chain dehydrogenase reductase F3L01_RS17375 ENOG4106IQC argininosuccinate lyase F3L01_RS17390 ENOG4108IA2 Sodium pantothenate symporter F3L01_RS17440 ENOG4105CHR reductase F3L01_RS17450 ENOG4105EWU Squalene--hopene cyclase F3L01_RS17460 ENOG4105FR1 rard protein F3L01_RS17465 ENOG410696E Membrane F3L01_RS17480 ENOG4105D1F ATP-binding protein F3L01_RS17490 ENOG4108ZAF Molybdopterin F3L01_RS17495 ENOG4105CVM Molybdenum cofactor synthesis domain protein F3L01_RS17500 ENOG4105D06 uba thif-type nad fad binding protein F3L01_RS17505 ENOG4105TMB Formate nitrite transporter F3L01_RS17515 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) F3L01_RS17520 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) F3L01_RS17530 ENOG4108JB9 formate dehydrogenase F3L01_RS17535 ENOG4105E1K spore germination protein F3L01_RS17550 ENOG4105CUB amino acid F3L01_RS17610 ENOG4108KGH TRANSCRIPTIONal F3L01_RS17620 ENOG4105EMN RNA polymerase sigma factor F3L01_RS17630 ENOG4105CIG ABC transporter F3L01_RS17640 ENOG4105D9R oxidoreductase F3L01_RS17650 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F3L01_RS17655 ENOG4105K4P CoA-binding domain protein F3L01_RS17660 ENOG4105C0H protease F3L01_RS17665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_RS17675 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase F3L01_RS17685 ENOG4105W8X HesB YadR YfhF-family protein F3L01_RS17695 ENOG4105D7V transposase F3L01_RS17720 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) F3L01_RS17725 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F3L01_RS17735 ENOG4108JJA ABC, transporter F3L01_RS17740 ENOG4108I0Z Aconitate hydratase F3L01_RS17770 ENOG4105E5W Transporter F3L01_RS17780 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F3L01_RS17800 ENOG4107F3J Amp-dependent synthetase and ligase F3L01_RS17805 ENOG4107ZYJ bioY protein F3L01_RS17810 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_RS17815 ENOG4108IMY Transcriptional regulator F3L01_RS17855 ENOG4107AYK membrAne F3L01_RS17865 ENOG4105BZU Histidine kinase F3L01_RS17870 ENOG4105FBA Phospholipase Carboxylesterase F3L01_RS17880 ENOG4105CK7 Sodium proline symporter F3L01_RS17885 ENOG4105CBC glutamate synthase F3L01_RS17890 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F3L01_RS17895 ENOG4108VJ1 Transcriptional regulator (CarD family F3L01_RS17955 ENOG4107QIV Cytochrome c biogenesis protein F3L01_RS17975 ENOG4105CJ1 ABC, transporter F3L01_RS17990 ENOG4107RSM transcriptional regulator F3L01_RS18000 ENOG41067MG lrgb family F3L01_RS18040 ENOG4105BZ1 (ABC) transporter F3L01_RS18045 ENOG4105BZ1 (ABC) transporter F3L01_RS18080 ENOG4108HW3 (ABC) transporter F3L01_RS18095 ENOG4108SVB resolvase F3L01_RS18115 ENOG4105K7K Transcriptional regulator F3L01_RS18120 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase F3L01_RS18140 ENOG4105E4C Lytic transglycosylase catalytic F3L01_RS18145 ENOG41065S2 pneumococcal vaccine antigen F3L01_RS18220 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase F3L01_RS18225 ENOG4105XSJ toxin secretion phage lysis holin F3L01_RS18500 ENOG4105C5F glutamine synthetase F3L01_RS18505 ENOG4105KV4 Transcriptional regulator F3L01_RS18510 ENOG4105CXI aluminum resistance protein F3L01_RS18515 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F3L01_RS18520 ENOG4105EN6 Membrane F3L01_RS18530 ENOG4106F1P AAA ATPase, central domain protein F3L01_RS18560 ENOG41069ER domain protein F3L01_RS18570 ENOG4105DM4 PTS System F3L01_RS18575 ENOG4105DE4 1-phosphofructokinase F3L01_RS18580 ENOG4105E98 transcriptional regulator DeoR family F3L01_RS18585 ENOG4107QW4 alcohol dehydrogenase F3L01_RS18590 ENOG4108SJC Membrane F3L01_RS18600 ENOG4105C85 amino acid F3L01_RS18615 ENOG4105TMB Formate nitrite transporter F3L01_RS18620 ENOG4105K70 DNA-binding protein F3L01_RS18630 ENOG4105C59 p-type ATPase F3L01_RS18635 ENOG410681U heavy metal transport detoxification protein F3L01_RS18640 ENOG4105VPX protein, conserved in bacteria F3L01_RS18650 ENOG4105NIV Esterase F3L01_RS18655 ENOG4105E0A ABC, transporter F3L01_RS18675 ENOG4105CGK Exodeoxyribonuclease III F3L01_RS18685 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F3L01_RS18690 ENOG4105D03 DNA-3-methyladenine glycosylase II F3L01_RS18695 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) F3L01_RS18715 ENOG4105BZU Histidine kinase F3L01_RS18755 ENOG41067MG lrgb family F3L01_RS18775 ENOG4108S3Y transcriptional regulator F3L01_RS18780 ENOG4105CS2 ec 3.2.1.21 F3L01_RS18795 ENOG4105F0V Cell wall hydrolase F3L01_RS18805 ENOG4105E0M Sulfatase F3L01_RS18810 ENOG410890F Dynamin family F3L01_RS18840 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) F3L01_RS18845 ENOG4105DQU oxidoreductase, subunit beta F3L01_RS18850 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein F3L01_RS18855 ENOG4108IGT Dipeptidase F3L01_RS18860 ENOG4105MCT stage V sporulation protein S F3L01_RS18865 ENOG4105D48 metallophosphoesterase F3L01_RS18880 ENOG4105CEV competence damage-inducible protein F3L01_RS18885 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase F3L01_RS18900 ENOG4105XZV Protein of unknown function (DUF3243) F3L01_RS18905 ENOG4108RKS Short-chain dehydrogenase reductase Sdr F3L01_RS18925 ENOG4105UIB (ABC) transporter F3L01_RS18930 ENOG4108JQ9 ABC transporter F3L01_RS18935 ENOG4105DIH basic membrane F3L01_RS18940 ENOG4105FDP GntR family transcriptional regulator F3L01_RS18945 ENOG4107QZI cell division protein FtsK F3L01_RS18955 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit F3L01_RS18965 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F3L01_RS18975 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) F3L01_RS18980 ENOG4108S0H Dipicolinic acid synthetase, b subunit F3L01_RS18985 ENOG4105E35 Dipicolinate synthase subunit A F3L01_RS18995 ENOG4105C1V Peptidase, M16 F3L01_RS19015 ENOG4105DTN riboflavin biosynthesis protein ribF F3L01_RS19030 ENOG4105W7A Protein of unknown function (DUF503) F3L01_RS19040 ENOG4105VHM ribosomal protein F3L01_RS19045 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination F3L01_RS19050 ENOG4105CHV Transcription elongation factor NusA F3L01_RS19060 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) F3L01_RS19070 ENOG4105DZP Membrane-associated zinc metalloprotease F3L01_RS19075 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) F3L01_RS19080 ENOG4105KNE Phosphatidate cytidylyltransferase F3L01_RS19085 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) F3L01_RS19095 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) F3L01_RS19125 ENOG4108HE4 integrase family F3L01_RS19135 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F3L01_RS19140 ENOG4105C79 DNA protecting protein DprA F3L01_RS19145 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha F3L01_RS19160 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) F3L01_RS19185 ENOG4105VB6 UPF0109 protein F3L01_RS19205 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) F3L01_RS19210 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) F3L01_RS19225 ENOG4105CHR reductase F3L01_RS19230 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase F3L01_RS19245 ENOG4105CB5 ATP-dependent DNA helicase recG F3L01_RS19250 ENOG4105DP4 dak2 domain fusion protein ylov F3L01_RS19255 ENOG4108ZAA Alkaline-shock protein F3L01_RS19270 ENOG4105FJ0 thiamine F3L01_RS19275 ENOG4105DJV ribulose-phosphate 3-epimerase F3L01_RS19280 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) F3L01_RS19285 ENOG4105D9P serine threonine protein kinase F3L01_RS19290 ENOG4108ZF3 Phosphatase F3L01_RS19295 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs F3L01_RS19300 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B F3L01_RS19315 ENOG4105C25 Primosomal protein n' F3L01_RS19320 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase F3L01_RS19340 ENOG4105DSJ YicC domain protein F3L01_RS19360 ENOG4105DC7 peptidase M24 F3L01_RS19395 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) F3L01_RS19410 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) F3L01_RS19415 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain F3L01_RS19425 ENOG4105CD3 dihydroorotase F3L01_RS19445 ENOG4105C34 Pseudouridine synthase F3L01_RS19470 ENOG4105DBK s4 domain protein F3L01_RS19475 ENOG41067XK integral membrane protein F3L01_RS19485 ENOG4105DFA alanine racemase domain protein F3L01_RS19490 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase F3L01_RS19495 ENOG4105WR5 sporulation protein, YlmC YmxH family F3L01_RS19505 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_RS19515 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) F3L01_RS19520 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) F3L01_RS19530 ENOG4105D4A Cell wall formation (By similarity) F3L01_RS19535 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) F3L01_RS19540 ENOG4105CNI cell division protein FtsW F3L01_RS19545 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) F3L01_RS19555 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) F3L01_RS19560 ENOG4105CJN penicillin-binding protein F3L01_RS19565 ENOG4105CJN penicillin-binding protein F3L01_RS19580 ENOG41074B2 UPF0747 protein F3L01_RS19605 ENOG4105KNH Nucleic acid-binding protein F3L01_RS19640 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase F3L01_RS19645 ENOG4105XSJ toxin secretion phage lysis holin F3L01_RS19715 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F3L01_RS19725 ENOG4105CAR Terminase, large subunit F3L01_RS19820 ENOG4105KRN Transcriptional regulator, abrb family F3L01_RS19850 ENOG4108IMY Transcriptional regulator F3L01_RS19865 ENOG41067QW Transcriptional regulator F3L01_RS19885 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) F3L01_RS19895 ENOG41063PX domain protein F3L01_RS19900 ENOG4105D78 K07001 NTE family protein F3L01_RS19905 ENOG4105H20 Sporulation integral membrane protein YlbJ F3L01_RS19915 ENOG4106H78 methyltransferase F3L01_RS19935 ENOG4107TB6 phosphoglycerate mutase F3L01_RS19950 ENOG4106UY4 Inherit from COG: Scp-like extracellular F3L01_RS19995 ENOG4107VFP cytochrome oxidase assembly F3L01_RS20000 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) F3L01_RS20005 ENOG4105CNI cell division protein FtsW F3L01_RS20020 ENOG4108IAB Phoh family F3L01_RS20040 ENOG4105QA2 F3L01_RS20045 ENOG4105CI3 gtp-binding protein typa F3L01_RS20055 ENOG4105ECY inositol monophosphatase F3L01_RS20075 ENOG4105CXN decarboxylase F3L01_RS20125 ENOG4105CPP Dehydrogenase, E1 component F3L01_RS20140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) F3L01_RS20145 ENOG4108X4Q Hydrolase F3L01_RS20155 ENOG4105CN5 Metallo-Beta-Lactamase F3L01_RS20160 ENOG4107ZYR domain protein F3L01_RS20195 ENOG4108XRC Protein of unknown function (DUF458) F3L01_RS20205 ENOG4107IN1 Protein of unknown function (DUF1797) F3L01_RS20220 ENOG4105EPM Diguanylate phosphodiesterase F3L01_RS20225 ENOG4105K6S Short-chain dehydrogenase reductase Sdr F3L01_RS20240 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) F3L01_RS20250 ENOG4105UIN F3L01_RS20285 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) F3L01_RS20300 ENOG4105EKQ RNA-directed DNA polymerase F3L01_RS20315 ENOG4108HGU Histidine kinase F3L01_RS20325 ENOG4105CHM Aminotransferase F3L01_RS20330 ENOG4105FKQ transcriptional regulator F3L01_RS20335 ENOG4105EG2 ABC transporter, permease F3L01_RS20345 ENOG4107FKK extracellular solute-binding protein family 1 F3L01_RS20355 ENOG4105CG3 alpha amylase, catalytic region F3L01_RS20400 ENOG4105CHU acetyl-coa acetyltransferase F3L01_RS20430 ENOG4105K7K Transcriptional regulator F3L01_RS20435 ENOG4105DTD Dehydrogenase F3L01_RS20450 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) F3L01_RS20455 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase F3L01_RS20465 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate F3L01_RS20480 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) F3L01_RS20495 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F3L01_RS20505 ENOG4105BZU Histidine kinase F3L01_RS20525 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F3L01_RS20540 ENOG4105CID antiterminator F3L01_RS20560 ENOG4105CE4 GlcNAc 6-P deacetylase F3L01_RS20595 ENOG4107ZE5 PPIases accelerate the folding of proteins F3L01_RS20600 ENOG4105PTM secreted protein F3L01_RS20605 ENOG4105J7I hydrolase F3L01_RS20615 ENOG4105G6R Stage v sporulation protein ae F3L01_RS20625 ENOG4105CZ3 stage V sporulation protein ad F3L01_RS20630 ENOG41090VF Stage v sporulation protein ac F3L01_RS20650 ENOG4105C8J )-transporter F3L01_RS20655 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_RS20665 ENOG41082AN stage II sporulation protein F3L01_RS20670 ENOG4105DZ1 carboxypeptidase F3L01_RS20675 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family F3L01_RS20680 ENOG4105DVE abc transporter atp-binding protein F3L01_RS20715 ENOG4105D7N magnesium and cobalt transport protein CorA F3L01_RS20740 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F3L01_RS20750 ENOG4105I3K Ferric uptake regulator, Fur family F3L01_RS20755 ENOG4105MZ9 stage II sporulation protein m F3L01_RS20775 ENOG4105CPC Aldo Keto reductase F3L01_RS20785 ENOG4105RHY Pfam:UPF0157 F3L01_RS20805 ENOG4107SKW Inherit from COG: Alpha beta hydrolase F3L01_RS20815 ENOG4105ETE Transcriptional regulator (LacI family F3L01_RS20820 ENOG4108YM7 Gcn5-related n-acetyltransferase F3L01_RS20840 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) F3L01_RS20845 ENOG4108R6K riboflavin synthase, subunit alpha F3L01_RS20870 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F3L01_RS20875 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F3L01_RS20885 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) F3L01_RS20890 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F3L01_RS20900 ENOG4105DFD Na H antiporter F3L01_RS20905 ENOG4105CGH 5'-nucleotidase F3L01_RS20930 ENOG4105DBV ornithine carbamoyltransferase F3L01_RS20945 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) F3L01_RS20960 ENOG4108IXY short-chain dehydrogenase reductase F3L01_RS20965 ENOG41069FQ Metallo-beta-lactamase superfamily F3L01_RS20970 ENOG4105II7 pyrroline-5-carboxylate reductase F3L01_RS20975 ENOG4105EJQ L-serine dehydratase F3L01_RS20990 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) F3L01_RS21005 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) F3L01_RS21010 ENOG4105D9U N-acetyltransferase F3L01_RS21025 ENOG4108VZI ErfK ybiS ycfS ynhG family protein F3L01_RS21030 ENOG4108QEG Membrane F3L01_RS21035 ENOG4105CDA abc transporter atp-binding protein F3L01_RS21040 ENOG4105E5Q amino acid AbC transporter F3L01_RS21045 ENOG4108HW3 (ABC) transporter F3L01_RS21055 ENOG4105G7B Protein of unknown function (DUF2992) F3L01_RS21065 ENOG4108QY0 Membrane F3L01_RS21075 ENOG4105C7S Dehydrogenase F3L01_RS21080 ENOG4105CPP Dehydrogenase, E1 component F3L01_RS21095 ENOG4105CKM Branched-chain carboxylic acid kinase F3L01_RS21100 ENOG4107RDP Dehydrogenase F3L01_RS21110 ENOG4108JUB Transcriptional regulator F3L01_RS21120 ENOG4108QXE glycerophosphoryl diester phosphodiesterase F3L01_RS21135 ENOG4107QQR Sporulation F3L01_RS21140 ENOG4105S1Z Stage IV sporulation protein B F3L01_RS21145 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) F3L01_RS21150 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) F3L01_RS21155 ENOG4105DX0 Hemolysin A F3L01_RS21165 ENOG4105CTB Polyprenyl synthetase F3L01_RS21180 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) F3L01_RS21190 ENOG4108ZSR alkaline shock protein F3L01_RS21195 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F3L01_RS21220 ENOG410644B Stage III sporulation protein af F3L01_RS21230 ENOG4105KQ4 Stage iii sporulation protein ad F3L01_RS21235 ENOG4108CQH stage III sporulation protein AC F3L01_RS21240 ENOG4105KR5 Stage iii sporulation protein F3L01_RS21245 ENOG4105CD2 stage iii sporulation protein aa F3L01_RS21270 ENOG4105DC7 peptidase M24 F3L01_RS21275 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) F3L01_RS21285 ENOG4105CBJ Metal-dependent enzyme F3L01_RS21295 ENOG4107YBY Hydrolase F3L01_RS21325 ENOG41082GG biotin lipoate A B protein ligase F3L01_RS21330 ENOG4105WZW rhodanese family F3L01_RS21355 ENOG41080TC multidrug resistance protein F3L01_RS21395 ENOG4105C0D helicase F3L01_RS21470 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F3L01_RS21500 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) F3L01_RS21570 ENOG4107R6U sodium dicarboxylate symporter F3L01_RS21605 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) F3L01_RS21610 ENOG4105C3R Methionine synthase F3L01_RS21620 ENOG4105C28 cystathionine F3L01_RS21625 ENOG4105C28 cystathionine F3L01_RS21645 ENOG4105C5X domain protein F3L01_RS21655 ENOG4105DKQ ROK family F3L01_RS21665 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase F3L01_RS21680 ENOG4108UTW Plays a role in the regulation of phosphate uptake F3L01_RS21685 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) F3L01_RS21690 ENOG4105C8U phosphate abc transporter F3L01_RS21695 ENOG4105C8U phosphate abc transporter F3L01_RS21700 ENOG4105EXS phosphate abc transporter F3L01_RS21705 ENOG4107RF6 penicillin-binding protein F3L01_RS21715 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F3L01_RS21740 ENOG4105N80 Ferric uptake regulator, Fur family F3L01_RS21750 ENOG4105FDK ABC transporter F3L01_RS21755 ENOG4108JYZ YitT family F3L01_RS21760 ENOG41069ZM Protein of unknown function (DUF2624) F3L01_RS21785 ENOG4105EGD dinuclear metal center protein, YbgI family F3L01_RS21800 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_RS21805 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) F3L01_RS21835 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) F3L01_RS21840 ENOG4105KG3 cytidine deaminase F3L01_RS21845 ENOG4107YR5 Diacylglycerol kinase F3L01_RS21850 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) F3L01_RS21855 ENOG4105CTJ Metal Dependent Phosphohydrolase F3L01_RS21860 ENOG4105C9A Phoh family F3L01_RS21870 ENOG41068P3 sporulation protein YqfC F3L01_RS21875 ENOG4105KTH gatB Yqey F3L01_RS21885 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) F3L01_RS21890 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) F3L01_RS21920 ENOG4105CSA Coproporphyrinogen iii oxidase F3L01_RS21925 ENOG4105KVH Transcriptional regulator F3L01_RS21950 ENOG4105TQK DNA polymerase iii, delta' subunit F3L01_RS21960 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 F3L01_RS21965 ENOG4108UK2 deaminase F3L01_RS21970 ENOG4105KQC Competence protein F3L01_RS21980 ENOG4105DXX methyltransferase F3L01_RS21990 ENOG4108WF2 Metal Dependent Phosphohydrolase F3L01_RS22000 ENOG410812S Rna-binding protein F3L01_RS22010 ENOG4105CQW ribosome biogenesis GTPase YqeH F3L01_RS22015 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase F3L01_RS22030 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_RS22050 ENOG4108TVJ Nitroreductase F3L01_RS22065 ENOG4105G6Z alkaline phosphatase F3L01_RS22070 ENOG4105KEG ribosomal-protein-alanine acetyltransferase F3L01_RS22075 ENOG4108MUZ hydrolase F3L01_RS22115 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin F3L01_RS22120 ENOG4105MIR Phenylalanine 4-monooxygenase F3L01_RS22130 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase F3L01_RS22170 ENOG4105S6R Iron-hydroxamate transporter permease subunit F3L01_RS22175 ENOG4108V5C ABC transporter F3L01_RS22185 ENOG4105C0A alcohol dehydrogenase F3L01_RS22190 ENOG4105C28 cystathionine F3L01_RS22220 ENOG4107XRG penicillin-binding protein F3L01_RS22230 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) F3L01_RS22240 ENOG4105CFP Peptidase U32 F3L01_RS22245 ENOG4105XYU peptidase (U32 family) F3L01_RS22255 ENOG4105HHA aminodeoxychorismate lyase F3L01_RS22275 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F3L01_RS22285 ENOG4105C02 permease F3L01_RS22300 ENOG41060CR F3L01_RS22305 ENOG4105C7H Helicase, RecD TraA family F3L01_RS22315 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) F3L01_RS22320 ENOG4105C3J Cysteine desulfurase F3L01_RS22330 ENOG4105D1H recombination factor protein RarA F3L01_RS22335 ENOG4108VCI transcription factor, rsfa family F3L01_RS22340 ENOG4105CUZ uba thif-type nad fad binding protein F3L01_RS22350 ENOG4105CUT histidyl-tRNA synthetase F3L01_RS22360 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) F3L01_RS22365 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F3L01_RS22375 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) F3L01_RS22380 ENOG41076HS cation diffusion facilitator family transporter F3L01_RS22385 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F3L01_RS22395 ENOG4105CKP Polysaccharide Biosynthesis Protein F3L01_RS22400 ENOG4108QG2 Membrane F3L01_RS22410 ENOG4105VIE preprotein translocase, subunit YajC F3L01_RS22425 ENOG41061AI Protein of unknown function (DUF2905) F3L01_RS22440 ENOG4108HUF Transporter F3L01_RS22465 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) F3L01_RS22470 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase F3L01_RS22475 ENOG4108IYU L-aspartate oxidase F3L01_RS22490 ENOG4108RPX mosc domain containing protein F3L01_RS22495 ENOG4105CQC Prephenate dehydratase F3L01_RS22510 ENOG4105C19 ABC transporter F3L01_RS22515 ENOG4105EWM Histidine kinase F3L01_RS22525 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control F3L01_RS22540 ENOG4105X36 (ribosomal) protein F3L01_RS22550 ENOG4105C03 ribonuclease F3L01_RS22565 ENOG4107QMS site-determining protein F3L01_RS22585 ENOG4105DFF Rod shape-determining protein mreb F3L01_RS22595 ENOG4108Z03 MAF-like protein F3L01_RS22605 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase F3L01_RS22610 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) F3L01_RS22620 ENOG41068KH stage VI sporulation protein D F3L01_RS22630 ENOG4105D52 delta-aminolevulinic acid dehydratase F3L01_RS22655 ENOG4105K56 Transcriptional regulator F3L01_RS22675 ENOG4108IUQ atp-dependent protease F3L01_RS22700 ENOG4108QCI YvbH-like oligomerisation region F3L01_RS22720 ENOG4105M59 Phosphodiesterase, mj0936 family F3L01_RS22725 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) F3L01_RS22735 ENOG4108XJQ germination protein F3L01_RS22745 ENOG4108PCX Major Facilitator F3L01_RS22755 ENOG4105KBX Transcriptional regulator, TetR family F3L01_RS22765 ENOG4105PFC Transcriptional regulator F3L01_RS22775 ENOG4105DZC cytosine deaminase F3L01_RS22780 ENOG41067S9 phage shock protein C, PspC F3L01_RS22785 ENOG4108JCI Transcriptional regulator F3L01_RS22795 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F3L01_RS22800 ENOG4108Z40 Transcriptional regulator F3L01_RS22805 ENOG4105RHA ABC transporter, permease F3L01_RS22810 ENOG4108IUX (ABC) transporter F3L01_RS22815 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family F3L01_RS22820 ENOG4105ER2 Ompa motb domain protein F3L01_RS22825 ENOG4105E14 MotA TolQ exbB proton channel F3L01_RS22830 ENOG4108VXD carboxy-peptidase F3L01_RS22840 ENOG4105E33 succinate dehydrogenase F3L01_RS22850 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit F3L01_RS22860 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) F3L01_RS22865 ENOG4105K63 Thioredoxin F3L01_RS22870 ENOG4105C10 Electron transfer flavoprotein F3L01_RS22875 ENOG4105BZJ Electron transfer flavoprotein F3L01_RS22880 ENOG41060WC Enoyl-CoA hydratase F3L01_RS22885 ENOG4107Z3H Transcriptional regulator, TetR family F3L01_RS22890 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_RS22900 ENOG4105J76 Periplasmic binding protein F3L01_RS22905 ENOG4105S6R Iron-hydroxamate transporter permease subunit F3L01_RS22955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_RS22970 ENOG4105DR4 Methyltransferase F3L01_RS22980 ENOG4105KFN sortase, SrtB family F3L01_RS22985 ENOG4105E0A ABC, transporter F3L01_RS23000 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) F3L01_RS23010 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) F3L01_RS23020 ENOG4105FE9 pseudouridine synthase F3L01_RS23030 ENOG4105DCG PHP domain protein F3L01_RS23045 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F3L01_RS23065 ENOG4105C5S asparaginyl-tRNA synthetase F3L01_RS23070 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) F3L01_RS23080 ENOG4108RWN rrna methyltransferase F3L01_RS23110 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L01_RS23115 ENOG4105CW7 secretion protein, HlyD family F3L01_RS23120 ENOG4108JGH Tetr family transcriptional regulator F3L01_RS23125 ENOG4105CN9 Peptidase m42 family protein F3L01_RS23145 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) F3L01_RS23150 ENOG4105C22 threonyL-tRNA synthetase F3L01_RS23155 ENOG4108TDW sporulation protein YtxC F3L01_RS23190 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F3L01_RS23195 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) F3L01_RS23205 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) F3L01_RS23210 ENOG4105C2M dna polymerase I F3L01_RS23215 ENOG4105BZU Histidine kinase F3L01_RS23220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_RS23235 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F3L01_RS23240 ENOG4108HMX isocitrate dehydrogenase (NADP) F3L01_RS23245 ENOG4105BZN citrate synthase F3L01_RS23255 ENOG4108REF Sporulation integral membrane protein ytvi F3L01_RS23260 ENOG4105FS0 cytoplasmic membrane protein F3L01_RS23285 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family F3L01_RS23290 ENOG4105C6K Malic enzyme F3L01_RS23295 ENOG4105C0B DNA polymerase III (alpha subunit) F3L01_RS23300 ENOG4105VV2 F3L01_RS23310 ENOG4105SFS phosphoesterase RecJ domain protein F3L01_RS23335 ENOG4105E8R UPF0173 metal-dependent hydrolase F3L01_RS23340 ENOG4105DC7 peptidase M24 F3L01_RS23375 ENOG4105Z7P Acetyltransferase (GNAT) family F3L01_RS23380 ENOG41082W1 Cupin 2, conserved barrel domain protein F3L01_RS23400 ENOG4107YZX Universal stress protein F3L01_RS23420 ENOG4105CH7 arginosuccinase F3L01_RS23440 ENOG4108JYZ YitT family F3L01_RS23460 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) F3L01_RS23470 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) F3L01_RS23475 ENOG4105KBJ sporulation protein ytfj F3L01_RS23490 ENOG4105EFZ amidohydrolase F3L01_RS23500 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F3L01_RS23525 ENOG4105RQF LysR family Transcriptional regulator F3L01_RS23535 ENOG4105U5Y Transcriptional regulator F3L01_RS23545 ENOG4105C28 cystathionine F3L01_RS23565 ENOG4108IBT Inherit from COG: transposase F3L01_RS23615 ENOG4108UW5 maltose o-acetyltransferase F3L01_RS23625 ENOG4105F1V Acetoin utilization protein F3L01_RS23630 ENOG4105W87 Cbs domain F3L01_RS23635 ENOG4105DGU Histone deacetylase F3L01_RS23650 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_RS23660 ENOG4107SNB ankyrin repeat protein YahD F3L01_RS23665 ENOG4105EP9 oxidoreductase F3L01_RS23685 ENOG4105ETE Transcriptional regulator (LacI family F3L01_RS23690 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase F3L01_RS23710 ENOG4105C88 aminopeptidase F3L01_RS23755 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F3L01_RS23765 ENOG4108VDD TRNA binding domain protein F3L01_RS23795 ENOG4105C8F Beta-lactamase domain protein F3L01_RS23810 ENOG4108V15 phosphotransferase enzyme family F3L01_RS23815 ENOG4108IUM Glycogen debranching enzyme F3L01_RS23825 ENOG4107QSE Dipeptidase F3L01_RS23830 ENOG4105YW5 deoR family transcriptional regulator F3L01_RS23845 ENOG4105CBX hi0933 family F3L01_RS23880 ENOG4108VJ1 Transcriptional regulator (CarD family F3L01_RS23885 ENOG4107EXU Short-chain dehydrogenase reductase Sdr F3L01_RS23890 ENOG4105CSC Glucose uptake protein F3L01_RS23905 ENOG4108ZAF Molybdopterin F3L01_RS23910 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein F3L01_RS23915 ENOG4105CVM Molybdenum cofactor synthesis domain protein F3L01_RS23925 ENOG4105D06 uba thif-type nad fad binding protein F3L01_RS23930 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F3L01_RS23950 ENOG41085GJ domain protein F3L01_RS23960 ENOG4105DWV Homoserine O-trans-acetylase F3L01_RS23970 ENOG4108B31 Spore germination protein F3L01_RS23995 ENOG4105C8T Leucyl-tRNA synthetase F3L01_RS24000 ENOG410605W Major Facilitator F3L01_RS24005 ENOG4107S91 Sodium hydrogen exchanger F3L01_RS24010 ENOG4105NCW Trka-c domain protein F3L01_RS24025 ENOG4105C19 ABC transporter F3L01_RS24045 ENOG4105N5T Radical SAM Protein F3L01_RS24055 ENOG4105CIG ABC transporter F3L01_RS24085 ENOG4105E8V Alpha Beta Hydrolase Fold protein F3L01_RS24090 ENOG4108Z0R Transferase F3L01_RS24095 ENOG4105YVM Phosphoesterase, PA-phosphatase related F3L01_RS24100 ENOG4105BZF Glycosyl transferase (Group 1 F3L01_RS24110 ENOG4105EPU Molybdenum cofactor synthesis domain protein F3L01_RS24120 ENOG4108MK9 spermidine N(1)-acetyltransferase F3L01_RS24165 ENOG4105BZU Histidine kinase F3L01_RS24170 ENOG4105BZU Histidine kinase F3L01_RS24185 ENOG4107S9D Alpha beta hydrolase F3L01_RS24190 ENOG4107T7U Sulfatase F3L01_RS24205 ENOG4105D2X ABC transporter substrate-binding protein F3L01_RS24215 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component F3L01_RS24280 ENOG4108V2W Carbonate dehydratase F3L01_RS24285 ENOG4105C4M (Ubiquinol oxidase) subunit I F3L01_RS24290 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F3L01_RS24325 ENOG41087YS Phage shock protein A F3L01_RS24355 ENOG4105BZU Histidine kinase F3L01_RS24360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_RS24385 ENOG4108UGV hypoxanthine phosphoribosyltransferase F3L01_RS24390 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) F3L01_RS24435 ENOG4105C19 ABC transporter F3L01_RS24450 ENOG4107ZTW SNARE associated Golgi F3L01_RS24465 ENOG4105C19 ABC transporter F3L01_RS24470 ENOG41086D8 Transcriptional regulator F3L01_RS24480 ENOG41082BM Transcriptional regulator, arsr family F3L01_RS24530 ENOG4105C6Z Gluconate F3L01_RS24535 ENOG4105FDP GntR family transcriptional regulator F3L01_RS24555 ENOG41069H0 dihydroorotase EC 3.5.2.3 F3L01_RS24575 ENOG4105DTQ mandelate racemase muconate lactonizing F3L01_RS24580 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_RS24585 ENOG4108IPT Naphthoate synthase F3L01_RS24590 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) F3L01_RS24595 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) F3L01_RS24600 ENOG4105E4F Isochorismate synthase F3L01_RS24605 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase F3L01_RS24615 ENOG4105VEQ Cold shock protein F3L01_RS24650 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) F3L01_RS24655 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) F3L01_RS24665 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin F3L01_RS24765 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation F3L01_RS24800 ENOG4105KT7 mgtC SapB transporter F3L01_RS24805 ENOG4107PBV potassium channel F3L01_RS24820 ENOG4105WG9 Conserved Protein F3L01_RS24830 ENOG4105CHM Aminotransferase F3L01_RS24835 ENOG4108ZB6 transcriptional regulator AsnC family F3L01_RS24840 ENOG4105C5I Dehydrogenase F3L01_RS24845 ENOG4108MUZ hydrolase F3L01_RS24855 ENOG4105C87 Aminotransferase class I and II F3L01_RS24870 ENOG4105Y38 Kinase-associated protein B F3L01_RS24880 ENOG4107R3E Citrate transporter F3L01_RS24900 ENOG4105KA0 thioesterase Superfamily protein F3L01_RS24915 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F3L01_RS24930 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) F3L01_RS24935 ENOG41069ER domain protein F3L01_RS24950 ENOG4105CEP NADH dehydrogenase F3L01_RS24980 ENOG4105EWC Purine nucleoside phosphorylase F3L01_RS25000 ENOG4108YX9 iron--sulfur cluster insertion protein erpA F3L01_RS25025 ENOG4108JJA ABC, transporter F3L01_RS25030 ENOG4105C4B ABC transporter, permease F3L01_RS25035 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA F3L01_RS25085 ENOG41083MR nifu domain-containing protein F3L01_RS25100 ENOG4108W5N phosphatidylglycerophosphatase a F3L01_RS25120 ENOG4105DAX Pfam:DUF2983 F3L01_RS25130 ENOG4105DYS nad(p)h dehydrogenase (quinone) F3L01_RS25140 ENOG4105D4U had-superfamily hydrolase, subfamily iia F3L01_RS25155 ENOG4105CBT Fructose-1,6-bisphosphatase F3L01_RS25175 ENOG4105MMD transcriptional regulator F3L01_RS25180 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) F3L01_RS25185 ENOG4107TXC Transcriptional regulator F3L01_RS25190 ENOG41090T1 Membrane F3L01_RS25215 ENOG4105FAA peptidase M23 F3L01_RS25220 ENOG4108YTE sporulation protein YunB F3L01_RS25225 ENOG4105KZD Domain of unknown function (DUF1805) F3L01_RS25230 ENOG4107R8B 5'-nucleotidase F3L01_RS25235 ENOG4105DIW FeS assembly protein SUFB F3L01_RS25240 ENOG4108UNV SUF system FeS assembly protein, NifU family F3L01_RS25245 ENOG4105C9B Cysteine desulfurase F3L01_RS25250 ENOG4105JRK feS assembly protein SufD F3L01_RS25255 ENOG4105C3K feS assembly ATPase SufC F3L01_RS25260 ENOG4105D01 (LipO)protein F3L01_RS25265 ENOG4105D01 (LipO)protein F3L01_RS25270 ENOG4108UMI ABC transporter, permease F3L01_RS25275 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F3L01_RS25300 ENOG41080E8 Transcriptional regulator, Spx MgsR family F3L01_RS25320 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F3L01_RS25345 ENOG4108W8B Beta-lactamase domain protein F3L01_RS25350 ENOG4105C1G acyl-Coa dehydrogenase F3L01_RS25355 ENOG4105CHU acetyl-coa acetyltransferase F3L01_RS25370 ENOG4105DZ1 carboxypeptidase F3L01_RS25390 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer F3L01_RS25405 ENOG4108SUT Major Facilitator Superfamily F3L01_RS25410 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) F3L01_RS25420 ENOG4107R7I amino acid F3L01_RS25440 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F3L01_RS25450 ENOG4107AYK membrAne F3L01_RS25485 ENOG4107ZTW SNARE associated Golgi F3L01_RS25495 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F3L01_RS25500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_RS25505 ENOG4105BZU Histidine kinase F3L01_RS25515 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) F3L01_RS25540 ENOG4105C8Q Methyl-accepting chemotaxis F3L01_RS25545 ENOG4105VG1 fes assembly suf system protein F3L01_RS25550 ENOG4105D4Y metalloprotease F3L01_RS25570 ENOG4107T5V SNARE associated Golgi F3L01_RS25575 ENOG4107S91 Sodium hydrogen exchanger F3L01_RS25580 ENOG4105NCW Trka-c domain protein F3L01_RS25590 ENOG4108RMU ferritin dps family protein F3L01_RS25605 ENOG4108URH decarboxylase F3L01_RS25615 ENOG41090A1 ferritin F3L01_RS25625 ENOG4105D9N nucleoside F3L01_RS25630 ENOG4105D9N nucleoside F3L01_RS25645 ENOG4108RYK Nad-dependent epimerase dehydratase F3L01_RS25660 ENOG4105CV8 reductase F3L01_RS25665 ENOG4105F27 Major Facilitator F3L01_RS25670 ENOG4105KVH Transcriptional regulator F3L01_RS25685 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) F3L01_RS25690 ENOG4105D4A Cell wall formation (By similarity) F3L01_RS25710 ENOG4105WMR Protein CrcB homolog F3L01_RS25715 ENOG4105WMR Protein CrcB homolog F3L01_RS25725 ENOG4108MK9 spermidine N(1)-acetyltransferase F3L01_RS25775 ENOG4108IPW abc transporter atp-binding protein F3L01_RS25780 ENOG4105CM4 permease protein F3L01_RS25795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_RS25800 ENOG4105EWM Histidine kinase F3L01_RS25805 ENOG4105CJZ response regulator F3L01_RS25810 ENOG4105C19 ABC transporter F3L01_RS25835 ENOG4105C19 ABC transporter F3L01_RS25870 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) F3L01_RS25880 ENOG4105XZU Preprotein translocase, subunit SecG F3L01_RS25885 ENOG41067MG lrgb family F3L01_RS25935 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_RS26190 ENOG4105VTR Integrase F3L01_RS26210 ENOG41090VF Stage v sporulation protein ac F3L01_RS26215 ENOG4105CZ3 stage V sporulation protein ad F3L01_RS26230 ENOG4108QY0 Membrane F3L01_RS26240 ENOG4105KRI phosphocarrier protein (HPr F3L01_RS26250 ENOG4105CHW UPF0052 protein F3L01_RS26260 ENOG4108Z4K mutator MutT protein F3L01_RS26270 ENOG4105C3M thioredoxin reductase F3L01_RS26280 ENOG4108S4C acetyltransferase F3L01_RS26290 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) F3L01_RS26300 ENOG41086DT Membrane protein of unknown function F3L01_RS26305 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F3L01_RS26310 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) F3L01_RS26325 ENOG4107TXC Transcriptional regulator F3L01_RS26345 ENOG4105DUM transcriptional regulator, lysR family F3L01_RS26355 ENOG4108WS4 fmn reductase F3L01_RS26370 ENOG4105BZ1 (ABC) transporter F3L01_RS26380 ENOG4105CN1 protease F3L01_RS26385 ENOG4105CRP Part of the ABC transporter FtsEX involved in F3L01_RS26390 ENOG4105CAK Cell division ATP-binding protein ftsE F3L01_RS26415 ENOG4108RDQ ABC transporter F3L01_RS26445 ENOG4105MS2 ribosomal subunit Interface protein F3L01_RS26450 ENOG4105VEQ Cold shock protein F3L01_RS26455 ENOG41081UC Inherit from COG: Competence protein F3L01_RS26465 ENOG4105K4H Nlp p60 protein F3L01_RS26470 ENOG4105KVH Transcriptional regulator F3L01_RS26480 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein F3L01_RS26485 ENOG4108KGH TRANSCRIPTIONal F3L01_RS26490 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase F3L01_RS26495 ENOG4105C6Y Udp-glucose 6-dehydrogenase F3L01_RS26500 ENOG4105ESV Glycosyl transferase, family 4 F3L01_RS26510 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F3L01_RS26530 ENOG4105F8D glycoside hydrolase family 4 F3L01_RS26535 ENOG4105VCP PTS System F3L01_RS26540 ENOG4105CK1 PTS System F3L01_RS26550 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) F3L01_RS26555 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) F3L01_RS26560 ENOG4105VCP PTS System F3L01_RS26570 ENOG4105VZJ PTS System F3L01_RS26590 ENOG4105ECB domain protein F3L01_RS26595 ENOG4107RSM transcriptional regulator F3L01_RS26625 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) F3L01_RS26630 ENOG4105DAA L-lactate F3L01_RS26640 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) F3L01_RS26650 ENOG4105E0M Sulfatase F3L01_RS26675 ENOG4107R8N Glycosyl transferase, family 2 F3L01_RS26680 ENOG4105C94 Transporter F3L01_RS26685 ENOG41069ER domain protein F3L01_RS26710 ENOG4105KBK Zinc finger, swim domain protein F3L01_RS26715 ENOG4105C0D helicase F3L01_RS26745 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_RS26755 ENOG4107RBB ABC transporter, permease F3L01_RS26760 ENOG4105C19 ABC transporter F3L01_RS26770 ENOG4105CXY transporter F3L01_RS26785 ENOG4105BZU Histidine kinase F3L01_RS26790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_RS26795 ENOG4105DG6 mannose-6-phosphate isomerase F3L01_RS26800 ENOG4105DM4 PTS System F3L01_RS26820 ENOG4108KGH TRANSCRIPTIONal F3L01_RS26825 ENOG4105DG6 mannose-6-phosphate isomerase F3L01_RS26830 ENOG4105CJT Mannose-1-phosphate guanylyltransferase F3L01_RS26840 ENOG4108TJN glycosyl transferase group 1 F3L01_RS26845 ENOG4105C6Y Udp-glucose 6-dehydrogenase F3L01_RS26875 ENOG4105D3Q Sugar transferase F3L01_RS26880 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F3L01_RS26885 ENOG4108RB3 Capsular polysaccharide biosynthesis protein F3L01_RS26890 ENOG4107YJ4 chain length determinant protein F3L01_RS26895 ENOG4105HTX biosynthesis protein F3L01_RS26900 ENOG4107YJ4 chain length determinant protein F3L01_RS26915 ENOG4105MT0 Sporulation transcriptional regulator spoiiid F3L01_RS26925 ENOG4105FRN stage II sporulation protein F3L01_RS26940 ENOG4105DY9 regulatoR F3L01_RS26970 ENOG4106778 Protein of unknown function (DUF1146) F3L01_RS26975 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L01_RS26980 ENOG4105C8S subunit m F3L01_RS26985 ENOG4105D65 subunit l F3L01_RS27010 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L01_RS27015 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F3L01_RS27025 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F3L01_RS27030 ENOG4105BZU Histidine kinase F3L01_RS27080 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) F3L01_RS27085 ENOG41062M3 atp synthase F3L01_RS27105 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) F3L01_RS27110 ENOG4108UIC UPF0340 protein F3L01_RS27115 ENOG4108YZG isomerase F3L01_RS27130 ENOG4108VGI doxx family F3L01_RS27135 ENOG4107XC4 flavin reductase domain protein, FMN-binding F3L01_RS27150 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F3L01_RS27160 ENOG4108ZXQ stage ii sporulation protein r F3L01_RS27165 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) F3L01_RS27170 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) F3L01_RS27175 ENOG4107104 thymidine kinase F3L01_RS27185 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) F3L01_RS27190 ENOG4105CBT Fructose-1,6-bisphosphatase F3L01_RS27195 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) F3L01_RS27215 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) F3L01_RS27230 ENOG4105C1G acyl-Coa dehydrogenase F3L01_RS27235 ENOG4105C1G acyl-Coa dehydrogenase F3L01_RS27240 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F3L01_RS27250 ENOG4105DF6 Fe-S oxidoreductase F3L01_RS27265 ENOG4105BZU Histidine kinase F3L01_RS27280 ENOG4105D4Y metalloprotease F3L01_RS27290 ENOG4105BZU Histidine kinase F3L01_RS27295 ENOG4105KCT ABC transporter F3L01_RS27300 ENOG4108M15 ABC transporter F3L01_RS27305 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) F3L01_RS27315 ENOG4105IIU Aminopeptidase F3L01_RS27335 ENOG4105DU6 RNA polymerase F3L01_RS27345 ENOG410684U Domain of unknown function (DUF1934) F3L01_RS27365 ENOG4105CYW agmatinase F3L01_RS27375 ENOG4105DXB Major Facilitator superfamily F3L01_RS27380 ENOG4107SWG transcriptional regulator MERR family F3L01_RS27385 ENOG4108QXE glycerophosphoryl diester phosphodiesterase F3L01_RS27390 ENOG4105BZ4 penicillin-binding protein F3L01_RS27395 ENOG4108XFG YwhD family F3L01_RS27400 ENOG4108Z4T Peptidase M50 F3L01_RS27405 ENOG41069HH 4-oxalocrotonate tautomerase F3L01_RS27410 ENOG4105DCI Phosphohydrolase F3L01_RS27415 ENOG4108MES Periplasmic binding protein F3L01_RS27420 ENOG4105E0A ABC, transporter F3L01_RS27425 ENOG4105EHG Permease protein F3L01_RS27430 ENOG4105DQ5 transport system permease protein F3L01_RS27440 ENOG4108VCI transcription factor, rsfa family F3L01_RS27450 ENOG4108IJ2 phosphate acetyltransferase F3L01_RS27465 ENOG4108VKI Cell wall hydrolase F3L01_RS27485 ENOG4107SVH Potassium channel protein F3L01_RS27495 ENOG410667J hydrolase F3L01_RS27500 ENOG4105VCH membrane F3L01_RS27510 ENOG4108TU7 Inherit from COG: (ABC) transporter F3L01_RS27515 ENOG4105CJ1 ABC, transporter F3L01_RS27520 ENOG41090WU lipolytic protein G-D-S-L family F3L01_RS27535 ENOG4105D6E homoserine dehydrogenase F3L01_RS27540 ENOG4105CVG Homoserine O-transsuccinylase F3L01_RS27560 ENOG4108Y4K DNA-binding transcriptional activator F3L01_RS27570 ENOG4105WH1 Two component transcriptional regulator luxr family F3L01_RS27575 ENOG4105BZU Histidine kinase F3L01_RS27580 ENOG4105DWF phosphomethylpyrimidine kinase F3L01_RS27585 ENOG4105BZU Histidine kinase F3L01_RS27590 ENOG4105VCD cytoplasmic protein F3L01_RS27595 ENOG4105D22 carbon starvation protein F3L01_RS27600 ENOG4105DY9 regulatoR F3L01_RS27605 ENOG41079KZ Major Facilitator Superfamily F3L01_RS27615 ENOG4105CG5 Glycosyl transferase (Group 1 F3L01_RS27625 ENOG4105EN6 Membrane F3L01_RS27630 ENOG4106YBV Methyl-accepting chemotaxis F3L01_RS27640 ENOG4108S4H thioesterase Superfamily protein F3L01_RS27645 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) F3L01_RS27660 ENOG4105K64 Glycosyl transferase, family 2 F3L01_RS27675 ENOG4105CKK Glycosyl transferase, family 2 F3L01_RS27680 ENOG4105C5H ABC transporter F3L01_RS27685 ENOG41067SE Tetr family transcriptional regulator F3L01_RS27695 ENOG4105E0X reductase F3L01_RS27700 ENOG4106F5Q Membrane F3L01_RS27715 ENOG4108NEV two component transcriptional regulator, LytTR family F3L01_RS27725 ENOG4107RGD Major Facilitator superfamily F3L01_RS27740 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F3L01_RS27750 ENOG4105IW1 AmiS UreI transporter F3L01_RS27755 ENOG4105CMR udp-glucose 4-epimerase F3L01_RS27760 ENOG4108UT2 hemolysin iii F3L01_RS27770 ENOG4105C1J atp-dependent rna helicase F3L01_RS27775 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) F3L01_RS27780 ENOG4105DPN Oligoendopeptidase f F3L01_RS27835 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) F3L01_RS27845 ENOG4105C0H protease F3L01_RS27850 ENOG4105Q2H domain protein F3L01_RS27865 ENOG4105BZU Histidine kinase F3L01_RS27870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_RS27895 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis F3L01_RS27900 ENOG4105CDU Replicative dna helicase F3L01_RS27910 ENOG4105BZR domain protein F3L01_RS27915 ENOG4108XMW Membrane F3L01_RS27925 ENOG4108UUM single-stranded DNA-binding protein F3L01_RS27935 ENOG4105C3G gtp-binding protein F3L01_RS27940 ENOG4105VDK protein, conserved in bacteria F3L01_RS27945 ENOG4105D8X mechanosensitive ion channel F3L01_RS27950 ENOG4108ZDA Sporulation protein YyaC F3L01_RS27955 ENOG4105FA0 parb-like partition protein F3L01_RS27960 ENOG4107QJE Chromosome Partitioning Protein F3L01_RS27975 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) F3L01_RS27980 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) F3L01_RS27990 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F3L01_RS28100 ENOG4106A7E Transcriptional regulator F3L01_RS28105 ENOG4108VB1 regulatoR F3L01_RS28195 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) F3L01_RS28200 ENOG4105D9M gamma-glutamylcysteine synthetase F3L01_RS28210 ENOG4105C4W S-formylglutathione hydrolase F3L01_RS28220 ENOG4105KVH Transcriptional regulator F3L01_RS28235 ENOG4105E1K spore germination protein F3L01_RS28240 ENOG4108B31 Spore germination protein F3L01_RS28260 ENOG4108QY0 Membrane F3L01_RS28275 ENOG4105CZ3 stage V sporulation protein ad F3L01_RS28280 ENOG41090VF Stage v sporulation protein ac F3L01_RS28295 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F3L01_RS28360 ENOG4105K59 histidine triad (HIT) protein F3L01_RS28385 ENOG41086D8 Transcriptional regulator F3L01_RS28430 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F3L01_RS28435 ENOG4105WFK nuclease F3L01_RS28440 ENOG4105EKQ RNA-directed DNA polymerase F3L01_RS28705 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) F3L01_RS28760 ENOG4105EKQ RNA-directed DNA polymerase F3L01_RS28825 ENOG4108Q5U germination protein, ger(x)c family