locus-tag	class	description
WR52_RS00010	COG0592	DNA-directed DNA polymerase activity
WR52_RS00015	COG2501	S4 domain
WR52_RS00025	COG0187	DNA topoisomerase II activity
WR52_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WR52_RS00075	COG0470	DNA polymerase III
WR52_RS00080	COG1774	PSP1 C-terminal conserved region
WR52_RS00090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WR52_RS00100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WR52_RS00105	COG2002	toxin-antitoxin pair type II binding
WR52_RS00115	COG0084	hydrolase, TatD family'
WR52_RS00135	COG4466	Protein conserved in bacteria
WR52_RS00150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WR52_RS00155	COG0251	oxidation-reduction process
WR52_RS00185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WR52_RS00190	COG2002	toxin-antitoxin pair type II binding
WR52_RS00195	COG2244	polysaccharide biosynthetic process
WR52_RS00200	COG3956	TIGRFAM MazG family protein
WR52_RS00205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WR52_RS00225	COG1098	S1 RNA binding domain
WR52_RS00240	COG2208	phosphoserine phosphatase activity
WR52_RS00250	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
WR52_RS00255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WR52_RS00270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WR52_RS00275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WR52_RS00280	COG0512	Glutamine amidotransferase of anthranilate synthase
WR52_RS00285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WR52_RS00290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WR52_RS00295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WR52_RS00300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WR52_RS00305	COG1396	sequence-specific DNA binding
WR52_RS00310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WR52_RS00400	COG3880	PFAM UvrB UvrC protein
WR52_RS00410	COG0542	response to heat
WR52_RS00415	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WR52_RS00425	COG4956	integral membrane protein (PIN domain superfamily)
WR52_RS00445	COG1045	serine acetyltransferase
WR52_RS00460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WR52_RS00465	COG3688	RNA-binding protein containing a PIN domain
WR52_RS00475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WR52_RS00480	COG0250	Participates in transcription elongation, termination and antitermination
WR52_RS00485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WR52_RS00505	COG2813	Specifically methylates the guanine in position
WR52_RS00520	COG1358	cellular component organization or biogenesis
WR52_RS00525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WR52_RS00590	COG0255	Belongs to the universal ribosomal protein uL29 family
WR52_RS00650	COG0201	protein transport
WR52_RS00660	COG0024	Methionine aminopeptidase
WR52_RS00670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WR52_RS00705	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
WR52_RS00730	COG0860	N-Acetylmuramoyl-L-alanine amidase
WR52_RS00735	COG0489	protein tyrosine kinase activity
WR52_RS00745	COG2194	sulfuric ester hydrolase activity
WR52_RS00750	COG0726	polysaccharide deacetylase
WR52_RS00830	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
WR52_RS00835	COG4856	YbbR-like protein
WR52_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS00880	COG2011	ABC-type metal ion transport system permease component
WR52_RS00885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WR52_RS00890	COG1464	Belongs to the NlpA lipoprotein family
WR52_RS00895	COG0604	alcohol dehydrogenase
WR52_RS00905	COG0277	FAD linked oxidase domain protein
WR52_RS00910	COG2271	Major facilitator Superfamily
WR52_RS00920	COG2814	Major facilitator Superfamily
WR52_RS00935	COG2207	Transcriptional regulator
WR52_RS00950	COG4166	transmembrane transport
WR52_RS00955	COG4166	transmembrane transport
WR52_RS00960	COG0656	L-ascorbic acid biosynthetic process
WR52_RS00975	COG4149	molybdate abc transporter
WR52_RS00980	COG0725	ABC transporter, periplasmic molybdate-binding protein
WR52_RS00985	COG1910	domain protein
WR52_RS00995	COG0697	spore germination
WR52_RS01005	COG0204	Acyl-transferase
WR52_RS01010	COG1609	Transcriptional regulator
WR52_RS01020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_RS01040	COG5298	Protein conserved in bacteria
WR52_RS01060	COG0488	(ABC) transporter
WR52_RS01070	COG0747	negative chemotaxis
WR52_RS01075	COG0601	transmembrane transport
WR52_RS01080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WR52_RS01085	COG0444	Belongs to the ABC transporter superfamily
WR52_RS01090	COG4608	Belongs to the ABC transporter superfamily
WR52_RS01095	COG0561	phosphatase activity
WR52_RS01125	COG3185	4-Hydroxyphenylpyruvate dioxygenase
WR52_RS01130	COG0179	Fumarylacetoacetate (FAA) hydrolase
WR52_RS01140	COG0531	amino acid
WR52_RS01145	COG2814	Major facilitator Superfamily
WR52_RS01155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WR52_RS01165	COG4294	response to UV
WR52_RS01170	COG0705	Rhomboid family
WR52_RS01180	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WR52_RS01185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WR52_RS01190	COG0864	Transcriptional regulator
WR52_RS01195	COG2337	Toxic component of a toxin-antitoxin (TA) module
WR52_RS01200	COG2183	response to ionizing radiation
WR52_RS01295	COG0802	atpase or kinase
WR52_RS01300	COG1214	PFAM Peptidase M22, glycoprotease
WR52_RS01305	COG0456	acetyltransferase
WR52_RS01315	COG0488	(ABC) transporter
WR52_RS01330	COG1266	CAAX protease self-immunity
WR52_RS01350	COG2252	PERMEase
WR52_RS01360	COG5002	protein histidine kinase activity
WR52_RS01385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
WR52_RS01435	COG1215	transferase activity, transferring glycosyl groups
WR52_RS01470	COG2205	protein histidine kinase activity
WR52_RS01475	COG0745	RESPONSE REGULATOR receiver
WR52_RS01495	COG0697	spore germination
WR52_RS01525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WR52_RS01530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WR52_RS01535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WR52_RS01545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WR52_RS01560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WR52_RS01570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WR52_RS01580	COG0151	Belongs to the GarS family
WR52_RS01605	COG0210	DNA helicase
WR52_RS01615	COG4851	CamS sex pheromone cAM373 precursor
WR52_RS01630	COG1335	isochorismatase
WR52_RS01640	COG2011	ABC-type metal ion transport system permease component
WR52_RS01645	COG1464	Belongs to the NlpA lipoprotein family
WR52_RS01655	COG0003	Pfam Anion-transporting ATPase
WR52_RS01660	COG1846	Transcriptional regulator
WR52_RS01665	COG4682	membrane
WR52_RS01685	COG1597	lipid kinase activity
WR52_RS01695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WR52_RS01705	COG1012	belongs to the aldehyde dehydrogenase family
WR52_RS01710	COG2076	Multidrug Resistance protein
WR52_RS01720	COG2309	aminopeptidase activity
WR52_RS01735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_RS01745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WR52_RS01750	COG4807	Protein conserved in bacteria
WR52_RS01775	COG1757	Na H antiporter
WR52_RS01780	COG1473	amidohydrolase
WR52_RS01800	COG0450	alkyl hydroperoxide reductase
WR52_RS01820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_RS01825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_RS01830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_RS01835	COG0492	ferredoxin-NADP+ reductase activity
WR52_RS01845	COG0166	Belongs to the GPI family
WR52_RS01870	COG5002	protein histidine kinase activity
WR52_RS01890	COG3541	Predicted nucleotidyltransferase
WR52_RS01905	COG2814	Major facilitator Superfamily
WR52_RS01910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WR52_RS01910	COG0723	plastoquinol--plastocyanin reductase activity
WR52_RS01920	COG0765	amino acid transport
WR52_RS01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WR52_RS01935	COG0840	transmembrane signaling receptor activity
WR52_RS01960	COG0549	Belongs to the carbamate kinase family
WR52_RS01965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WR52_RS01975	COG0277	FAD linked oxidase domain protein
WR52_RS01980	COG0366	Alpha amylase catalytic
WR52_RS01985	COG2190	(PTS) system
WR52_RS01985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_RS01985	COG1263	PTS System
WR52_RS02015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WR52_RS02035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WR52_RS02040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WR52_RS02045	COG1116	anion transmembrane transporter activity
WR52_RS02090	COG2270	Major facilitator Superfamily
WR52_RS02120	COG2310	stress, protein
WR52_RS02125	COG2310	stress, protein
WR52_RS02130	COG2310	stress, protein
WR52_RS02135	COG0861	Integral membrane protein TerC family
WR52_RS02145	COG3853	Toxic anion resistance protein (TelA)
WR52_RS02160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WR52_RS02170	COG1295	ribonuclease BN
WR52_RS02175	COG2217	Heavy metal translocating P-type atpase
WR52_RS02180	COG0697	spore germination
WR52_RS02200	COG0586	Pfam SNARE associated Golgi protein
WR52_RS02215	COG3871	stress protein (general stress protein 26)
WR52_RS02220	COG0387	Pfam Sodium calcium exchanger
WR52_RS02230	COG0535	radical SAM domain protein
WR52_RS02250	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
WR52_RS02255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WR52_RS02270	COG3829	transcription factor binding
WR52_RS02280	COG0833	amino acid
WR52_RS02285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WR52_RS02310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_RS02310	COG1263	PTS System
WR52_RS02315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WR52_RS02330	COG1216	Glycosyl transferase, family 2
WR52_RS02340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WR52_RS02340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WR52_RS02345	COG0463	Glycosyl transferase, family 2
WR52_RS02360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WR52_RS02380	COG1228	amidohydrolase
WR52_RS02385	COG1090	epimerase
WR52_RS02415	COG1988	membrane-bound metal-dependent
WR52_RS02420	COG1194	a g-specific adenine glycosylase
WR52_RS02445	COG1132	(ABC) transporter
WR52_RS02450	COG4129	membrane
WR52_RS02455	COG0070	glutamate synthase
WR52_RS02455	COG0069	glutamate synthase activity
WR52_RS02455	COG0067	glutamate synthase
WR52_RS02465	COG4555	ABC transporter
WR52_RS02485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WR52_RS02490	COG0735	belongs to the Fur family
WR52_RS02610	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WR52_RS02635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WR52_RS02645	COG2766	serine protein kinase
WR52_RS02660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WR52_RS02670	COG1585	Membrane protein implicated in regulation of membrane protease activity
WR52_RS02675	COG2268	Band 7 protein
WR52_RS02685	COG3290	protein histidine kinase activity
WR52_RS02690	COG4565	transcriptional regulatory protein
WR52_RS02695	COG2851	Citrate transporter
WR52_RS02720	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
WR52_RS02725	COG3842	ATPase activity
WR52_RS02730	COG1175	transmembrane transport
WR52_RS02735	COG0395	ABC-type sugar transport system, permease component
WR52_RS02745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WR52_RS02750	COG0745	RESPONSE REGULATOR receiver
WR52_RS02755	COG5002	protein histidine kinase activity
WR52_RS02765	COG4990	cell redox homeostasis
WR52_RS02775	COG3290	protein histidine kinase activity
WR52_RS02780	COG4565	transcriptional regulatory protein
WR52_RS02785	COG3493	citrate carrier protein
WR52_RS02790	COG0281	malic enzyme
WR52_RS02800	COG0697	spore germination
WR52_RS02805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_RS02815	COG5002	protein histidine kinase activity
WR52_RS02835	COG0454	-acetyltransferase
WR52_RS02835	COG0456	acetyltransferase
WR52_RS02840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WR52_RS02845	COG3383	formate dehydrogenase (NAD+) activity
WR52_RS02850	COG2427	Protein of unknown function (DUF1641)
WR52_RS02865	COG0531	amino acid
WR52_RS02870	COG0640	Transcriptional regulator
WR52_RS02875	COG2217	Heavy metal translocating P-type atpase
WR52_RS02885	COG2801	Transposase and inactivated derivatives
WR52_RS02890	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WR52_RS02900	COG3227	Zinc metalloprotease (Elastase)
WR52_RS02920	COG2720	vancomycin resistance protein
WR52_RS02925	COG1316	TRANSCRIPTIONal
WR52_RS02930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_RS02935	COG0346	lactoylglutathione lyase activity
WR52_RS02940	COG1253	flavin adenine dinucleotide binding
WR52_RS02945	COG1027	Aspartate ammonia-lyase
WR52_RS02950	COG1620	l-lactate permease
WR52_RS02965	COG3104	oligopeptide transport
WR52_RS02970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_RS02975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_RS02980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_RS02990	COG2226	methyltransferase
WR52_RS03000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WR52_RS03010	COG4548	von Willebrand factor, type A
WR52_RS03015	COG0714	Associated with various cellular activities
WR52_RS03035	COG0531	amino acid
WR52_RS03040	COG2188	Transcriptional regulator
WR52_RS03045	COG1263	PTS System
WR52_RS03045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_RS03050	COG0366	Alpha amylase catalytic
WR52_RS03065	COG0697	spore germination
WR52_RS03070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WR52_RS03075	COG1115	amino acid carrier protein
WR52_RS03085	COG1126	abc transporter atp-binding protein
WR52_RS03090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WR52_RS03095	COG0765	amino acid transport
WR52_RS03100	COG0765	amino acid transport
WR52_RS03105	COG0833	amino acid
WR52_RS03120	COG2378	regulation of single-species biofilm formation
WR52_RS03125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WR52_RS03130	COG5002	protein histidine kinase activity
WR52_RS03155	COG0659	secondary active sulfate transmembrane transporter activity
WR52_RS03170	COG2271	Major facilitator Superfamily
WR52_RS03175	COG1846	Transcriptional regulator
WR52_RS03180	COG0477	Major facilitator Superfamily
WR52_RS03185	COG1609	Transcriptional regulator
WR52_RS03190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WR52_RS03205	COG1172	Belongs to the binding-protein-dependent transport system permease family
WR52_RS03210	COG1879	ABC-type sugar transport system periplasmic component
WR52_RS03230	COG1063	alcohol dehydrogenase
WR52_RS03280	COG0840	transmembrane signaling receptor activity
WR52_RS03285	COG3584	3D domain protein
WR52_RS03285	COG1388	LysM domain
WR52_RS03290	COG1476	TRANSCRIPTIONal
WR52_RS03310	COG3104	oligopeptide transport
WR52_RS03315	COG1114	Component of the transport system for branched-chain amino acids
WR52_RS03330	COG1113	amino acid transport
WR52_RS03335	COG2252	PERMEase
WR52_RS03360	COG2153	protein acetylation
WR52_RS03370	COG0569	domain protein
WR52_RS03370	COG0475	glutathione-regulated potassium exporter activity
WR52_RS03385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WR52_RS03395	COG0833	amino acid
WR52_RS03400	COG4990	cell redox homeostasis
WR52_RS03415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WR52_RS03420	COG0697	spore germination
WR52_RS03425	COG0531	amino acid
WR52_RS03435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WR52_RS03440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WR52_RS03445	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WR52_RS03445	COG1918	ferrous iron import across plasma membrane
WR52_RS03450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WR52_RS03455	COG0573	inorganic phosphate transmembrane transporter activity
WR52_RS03460	COG0581	inorganic phosphate transmembrane transporter activity
WR52_RS03470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WR52_RS03590	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
WR52_RS03620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WR52_RS03625	COG1116	anion transmembrane transporter activity
WR52_RS03630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WR52_RS03635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WR52_RS03640	COG0352	thiamine-phosphate diphosphorylase activity
WR52_RS03645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WR52_RS03650	COG2104	thiamine diphosphate biosynthetic process
WR52_RS03660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WR52_RS03665	COG0351	phosphomethylpyrimidine kinase
WR52_RS03705	COG2205	protein histidine kinase activity
WR52_RS03710	COG2814	Major facilitator Superfamily
WR52_RS03715	COG1846	Transcriptional regulator
WR52_RS03730	COG2252	PERMEase
WR52_RS03735	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS03750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WR52_RS03755	COG1621	beta-fructofuranosidase activity
WR52_RS03760	COG1263	PTS System
WR52_RS03760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_RS03765	COG1609	Transcriptional regulator
WR52_RS03815	COG0778	Nitroreductase
WR52_RS03820	COG2719	SpoVR family
WR52_RS03830	COG1414	Transcriptional regulator
WR52_RS03845	COG0446	pyridine nucleotide-disulphide oxidoreductase
WR52_RS03850	COG1937	Protein conserved in bacteria
WR52_RS03855	COG0425	Belongs to the sulfur carrier protein TusA family
WR52_RS03855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WR52_RS03860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_RS03860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WR52_RS03865	COG0425	Belongs to the sulfur carrier protein TusA family
WR52_RS03875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WR52_RS03880	COG2210	Belongs to the sulfur carrier protein TusA family
WR52_RS03885	COG0730	response to heat
WR52_RS03895	COG1316	TRANSCRIPTIONal
WR52_RS03900	COG0604	alcohol dehydrogenase
WR52_RS03905	COG1283	sodium-dependent phosphate transmembrane transporter activity
WR52_RS03920	COG3711	transcriptional antiterminator
WR52_RS03920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WR52_RS03925	COG1447	Phosphotransferase system cellobiose-specific component IIA
WR52_RS03930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WR52_RS03950	COG3584	3D domain protein
WR52_RS03950	COG1388	LysM domain
WR52_RS03955	COG0577	efflux transmembrane transporter activity
WR52_RS03960	COG1136	(ABC) transporter
WR52_RS03970	COG5522	Integral membrane protein (intg_mem_TP0381)
WR52_RS03985	COG1114	Component of the transport system for branched-chain amino acids
WR52_RS03990	COG3546	catalase activity
WR52_RS04025	COG0586	Pfam SNARE associated Golgi protein
WR52_RS04055	COG0531	amino acid
WR52_RS04060	COG0475	glutathione-regulated potassium exporter activity
WR52_RS04070	COG1737	Transcriptional regulator
WR52_RS04080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_RS04080	COG1263	PTS System
WR52_RS04090	COG2259	Doxx family
WR52_RS04110	COG1522	sequence-specific DNA binding
WR52_RS04115	COG0165	Argininosuccinate lyase
WR52_RS04115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WR52_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS04135	COG2076	Multidrug Resistance protein
WR52_RS04140	COG1309	transcriptional regulator
WR52_RS04145	COG2814	Major facilitator Superfamily
WR52_RS04150	COG1733	regulation of RNA biosynthetic process
WR52_RS04160	COG2249	NAD(P)H dehydrogenase (quinone) activity
WR52_RS04165	COG4533	DNA binding
WR52_RS04170	COG2211	Major facilitator Superfamily
WR52_RS04180	COG0693	protein deglycase activity
WR52_RS04185	COG0693	protein deglycase activity
WR52_RS04185	COG0753	catalase activity
WR52_RS04195	COG0531	amino acid
WR52_RS04210	COG1012	belongs to the aldehyde dehydrogenase family
WR52_RS04215	COG1132	(ABC) transporter
WR52_RS04220	COG1132	(ABC) transporter
WR52_RS04225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WR52_RS04230	COG0765	amino acid transport
WR52_RS04235	COG1126	abc transporter atp-binding protein
WR52_RS04250	COG0189	ligase activity
WR52_RS04270	COG4585	Histidine kinase
WR52_RS04275	COG2197	response regulator
WR52_RS04280	COG0028	Belongs to the TPP enzyme family
WR52_RS04285	COG3527	Alpha-acetolactate decarboxylase
WR52_RS04295	COG0561	phosphatase activity
WR52_RS04305	COG5632	N-Acetylmuramoyl-L-alanine amidase
WR52_RS04305	COG3409	Peptidoglycan-binding domain 1 protein
WR52_RS04310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WR52_RS04315	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_RS04330	COG0659	secondary active sulfate transmembrane transporter activity
WR52_RS04335	COG2244	polysaccharide biosynthetic process
WR52_RS04355	COG1024	Enoyl-CoA hydratase
WR52_RS04375	COG1363	Peptidase, m42
WR52_RS04390	COG2801	Transposase and inactivated derivatives
WR52_RS04420	COG0601	transmembrane transport
WR52_RS04425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WR52_RS04430	COG0444	Belongs to the ABC transporter superfamily
WR52_RS04435	COG4608	Belongs to the ABC transporter superfamily
WR52_RS04445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_RS04575	COG0477	Major facilitator Superfamily
WR52_RS04580	COG3290	protein histidine kinase activity
WR52_RS04585	COG4565	transcriptional regulatory protein
WR52_RS04605	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
WR52_RS04645	COG0305	Participates in initiation and elongation during chromosome replication
WR52_RS04665	COG0477	Major facilitator Superfamily
WR52_RS04680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_RS04705	COG1073	alpha beta
WR52_RS04755	COG1183	phosphatidylcholine synthase activity
WR52_RS04770	COG2376	Dihydroxyacetone kinase
WR52_RS04780	COG2376	Dihydroxyacetone kinase
WR52_RS04810	COG3584	3D domain protein
WR52_RS04810	COG1388	LysM domain
WR52_RS04815	COG0791	NLP P60 protein
WR52_RS04815	COG1388	LysM domain
WR52_RS04820	COG2373	Large extracellular alpha-helical protein
WR52_RS04840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WR52_RS04910	COG3237	CsbD-like
WR52_RS04935	COG1191	sigma factor activity
WR52_RS04945	COG2208	phosphoserine phosphatase activity
WR52_RS04950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WR52_RS04955	COG2205	protein histidine kinase activity
WR52_RS04955	COG5002	protein histidine kinase activity
WR52_RS04955	COG0784	Response regulator, receiver
WR52_RS04990	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
WR52_RS05010	COG0420	3'-5' exonuclease activity
WR52_RS05015	COG4717	serine-type aminopeptidase activity
WR52_RS05030	COG1280	lysine exporter protein (LysE YggA)
WR52_RS05035	COG0346	lactoylglutathione lyase activity
WR52_RS05040	COG0346	lactoylglutathione lyase activity
WR52_RS05045	COG0457	Tetratricopeptide repeat
WR52_RS05055	COG2267	carboxylic ester hydrolase activity
WR52_RS05075	COG2140	Oxalate decarboxylase
WR52_RS05085	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
WR52_RS05090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WR52_RS05100	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WR52_RS05160	COG1136	(ABC) transporter
WR52_RS05175	COG1595	DNA-templated transcription, initiation
WR52_RS05185	COG0772	Belongs to the SEDS family
WR52_RS05195	COG3973	AAA domain
WR52_RS05225	COG4980	gas vesicle protein
WR52_RS05230	COG0537	adenosine 5'-monophosphoramidase activity
WR52_RS05235	COG1131	(ABC) transporter
WR52_RS05240	COG4473	ABC transporter
WR52_RS05250	COG1309	transcriptional regulator
WR52_RS05260	COG3402	PFAM membrane-flanked domain
WR52_RS05265	COG3428	Bacterial PH domain
WR52_RS05300	COG0697	spore germination
WR52_RS05305	COG3402	PFAM membrane-flanked domain
WR52_RS05310	COG3428	Bacterial PH domain
WR52_RS05315	COG2329	Antibiotic biosynthesis monooxygenase
WR52_RS05320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WR52_RS05335	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
WR52_RS05360	COG1309	transcriptional regulator
WR52_RS05365	COG1511	domain protein
WR52_RS05385	COG2378	regulation of single-species biofilm formation
WR52_RS05390	COG1609	Transcriptional regulator
WR52_RS05400	COG1234	tRNA 3'-trailer cleavage
WR52_RS05405	COG0095	Lipoate-protein ligase
WR52_RS05415	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_RS05460	COG1408	metallophosphoesterase
WR52_RS05465	COG1078	dGTPase activity
WR52_RS05470	COG1595	DNA-templated transcription, initiation
WR52_RS05475	COG2207	Transcriptional regulator
WR52_RS05475	COG3708	Transcriptional regulator
WR52_RS05480	COG2205	protein histidine kinase activity
WR52_RS05485	COG0745	RESPONSE REGULATOR receiver
WR52_RS05505	COG0501	Belongs to the peptidase M48B family
WR52_RS05510	COG0840	transmembrane signaling receptor activity
WR52_RS05515	COG3693	PFAM glycoside hydrolase, family 10
WR52_RS05525	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WR52_RS05530	COG2224	Isocitrate lyase
WR52_RS05570	COG0398	Pfam SNARE associated Golgi protein
WR52_RS05630	COG0179	Fumarylacetoacetate (FAA) hydrolase
WR52_RS05655	COG0367	asparagine synthase
WR52_RS05665	COG0753	catalase activity
WR52_RS05670	COG0004	ammonium transporteR
WR52_RS05690	COG2996	Protein conserved in bacteria
WR52_RS05700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_RS05715	COG0561	phosphatase activity
WR52_RS05735	COG2267	carboxylic ester hydrolase activity
WR52_RS05755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WR52_RS05760	COG5504	Zn-dependent protease
WR52_RS05770	COG0180	Tryptophanyl-tRNA synthetase
WR52_RS05780	COG4166	transmembrane transport
WR52_RS05785	COG0601	transmembrane transport
WR52_RS05790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WR52_RS05795	COG0444	Belongs to the ABC transporter superfamily
WR52_RS05800	COG4608	Belongs to the ABC transporter superfamily
WR52_RS05805	COG0534	Mate efflux family protein
WR52_RS05810	COG4166	transmembrane transport
WR52_RS05825	COG0861	Integral membrane protein TerC family
WR52_RS05845	COG2801	Transposase and inactivated derivatives
WR52_RS05855	COG1164	Oligoendopeptidase f
WR52_RS05865	COG2346	COG2346, Truncated hemoglobins
WR52_RS05870	COG4116	CYTH
WR52_RS05880	COG2357	RelA SpoT domain protein
WR52_RS05890	COG0564	pseudouridine synthase activity
WR52_RS05905	COG0772	Belongs to the SEDS family
WR52_RS05910	COG1216	Glycosyl transferase, family 2
WR52_RS05930	COG0463	Glycosyl transferase, family 2
WR52_RS05930	COG0457	Tetratricopeptide repeat
WR52_RS05950	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WR52_RS05965	COG1091	dTDP-4-dehydrorhamnose reductase activity
WR52_RS06010	COG2153	protein acetylation
WR52_RS06020	COG2382	esterase
WR52_RS06040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WR52_RS06050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WR52_RS06050	COG0512	Glutamine amidotransferase of anthranilate synthase
WR52_RS06085	COG1620	l-lactate permease
WR52_RS06090	COG5634	Uncharacterized conserved protein (DUF2278)
WR52_RS06140	COG0508	dehydrogenase complex catalyzes the overall conversion of
WR52_RS06150	COG1476	TRANSCRIPTIONal
WR52_RS06210	COG1686	Belongs to the peptidase S11 family
WR52_RS06215	COG0681	Belongs to the peptidase S26 family
WR52_RS06250	COG1012	belongs to the aldehyde dehydrogenase family
WR52_RS06260	COG1176	ABC-type spermidine putrescine transport system, permease component I
WR52_RS06265	COG1177	transmembrane transport
WR52_RS06280	COG2409	Drug exporters of the RND superfamily
WR52_RS06290	COG0564	pseudouridine synthase activity
WR52_RS06300	COG2340	Cysteine-rich secretory protein family
WR52_RS06305	COG0247	lactate metabolic process
WR52_RS06310	COG0277	FAD linked oxidase domain protein
WR52_RS06315	COG3835	regulator
WR52_RS06325	COG0745	RESPONSE REGULATOR receiver
WR52_RS06330	COG5002	protein histidine kinase activity
WR52_RS06335	COG2186	Transcriptional regulator
WR52_RS06355	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WR52_RS06365	COG2116	formate transmembrane transporter activity
WR52_RS06370	COG0861	Integral membrane protein TerC family
WR52_RS06375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WR52_RS06385	COG2030	dehydratase
WR52_RS06405	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS06410	COG3243	poly(R)-hydroxyalkanoic acid synthase
WR52_RS06420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WR52_RS06435	COG1840	ABC-type Fe3 transport system, periplasmic component
WR52_RS06440	COG3842	ATPase activity
WR52_RS06465	COG1349	DNA-binding transcription factor activity
WR52_RS06480	COG0235	Class ii aldolase
WR52_RS06490	COG2861	carbohydrate metabolic process
WR52_RS06505	COG3852	Histidine kinase
WR52_RS06510	COG1846	Transcriptional regulator
WR52_RS06520	COG2318	DinB family
WR52_RS06530	COG5002	protein histidine kinase activity
WR52_RS06540	COG0720	synthase
WR52_RS06555	COG4873	Protein conserved in bacteria
WR52_RS06585	COG1780	Probably involved in ribonucleotide reductase function
WR52_RS06590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WR52_RS06595	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WR52_RS06600	COG1725	Transcriptional regulator
WR52_RS06605	COG1131	(ABC) transporter
WR52_RS06615	COG1131	(ABC) transporter
WR52_RS06620	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
WR52_RS06635	COG1522	sequence-specific DNA binding
WR52_RS06645	COG1335	isochorismatase
WR52_RS06655	COG1619	proteins homologs of microcin C7 resistance protein MccF
WR52_RS06660	COG2070	2-Nitropropane dioxygenase
WR52_RS06665	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
WR52_RS06675	COG1696	Membrane protein involved in D-alanine export
WR52_RS06700	COG0716	FMN binding
WR52_RS06760	COG1846	Transcriptional regulator
WR52_RS06770	COG1301	dicarboxylic acid transport
WR52_RS06775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WR52_RS06780	COG4709	membrane
WR52_RS06785	COG3874	Sporulation protein YtfJ
WR52_RS06805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WR52_RS06810	COG0028	Belongs to the TPP enzyme family
WR52_RS06815	COG0440	acetolactate synthase activity
WR52_RS06890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WR52_RS06905	COG1183	phosphatidylcholine synthase activity
WR52_RS06910	COG1368	sulfuric ester hydrolase activity
WR52_RS06920	COG0019	diaminopimelate decarboxylase activity
WR52_RS06940	COG0529	Catalyzes the synthesis of activated sulfate
WR52_RS06945	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WR52_RS06965	COG1648	precorrin-2 dehydrogenase activity
WR52_RS06970	COG0733	neurotransmitter:sodium symporter activity
WR52_RS06990	COG1757	Na H antiporter
WR52_RS07005	COG4758	membrane
WR52_RS07010	COG4585	Histidine kinase
WR52_RS07015	COG2197	response regulator
WR52_RS07025	COG1114	Component of the transport system for branched-chain amino acids
WR52_RS07035	COG2226	methyltransferase
WR52_RS07075	COG0730	response to heat
WR52_RS07080	COG0306	phosphate transporter
WR52_RS07085	COG1392	Phosphate transport regulator
WR52_RS07090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WR52_RS07105	COG3852	Histidine kinase
WR52_RS07110	COG1801	Protein of unknown function DUF72
WR52_RS07120	COG0582	viral genome integration into host DNA
WR52_RS07125	COG5002	protein histidine kinase activity
WR52_RS07140	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WR52_RS07140	COG0392	lysyltransferase activity
WR52_RS07155	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WR52_RS07160	COG1686	Belongs to the peptidase S11 family
WR52_RS07165	COG2715	membrane protein required for spore maturation
WR52_RS07170	COG0700	Nucleoside recognition
WR52_RS07175	COG1187	pseudouridine synthase activity
WR52_RS07185	COG1333	cytochrome c biogenesis protein
WR52_RS07190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WR52_RS07195	COG0745	RESPONSE REGULATOR receiver
WR52_RS07200	COG5002	protein histidine kinase activity
WR52_RS07205	COG2096	Adenosyltransferase
WR52_RS07220	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
WR52_RS07225	COG1141	Ferredoxin
WR52_RS07235	COG0514	ATP-dependent DNA helicase (RecQ)
WR52_RS07240	COG1266	CAAX protease self-immunity
WR52_RS07250	COG1408	metallophosphoesterase
WR52_RS07255	COG0789	Transcriptional regulator
WR52_RS07265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WR52_RS07285	COG0492	ferredoxin-NADP+ reductase activity
WR52_RS07290	COG0252	asparaginase activity
WR52_RS07355	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
WR52_RS07370	COG0142	geranyltranstransferase activity
WR52_RS07380	COG0142	geranyltranstransferase activity
WR52_RS07405	COG0457	Tetratricopeptide repeat
WR52_RS07425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WR52_RS07430	COG2010	Cytochrome c
WR52_RS07430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WR52_RS07435	COG4347	Protein of unknown function (DUF1405)
WR52_RS07450	COG2738	Putative neutral zinc metallopeptidase
WR52_RS07460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_RS07465	COG1694	Mazg nucleotide pyrophosphohydrolase
WR52_RS07485	COG0438	transferase activity, transferring glycosyl groups
WR52_RS07515	COG1199	ATP-dependent helicase activity
WR52_RS07515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WR52_RS07535	COG3935	DnaD domain protein
WR52_RS07540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WR52_RS07550	COG4499	WXG100 protein secretion system (Wss), protein YukC
WR52_RS07550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WR52_RS07605	COG0116	Belongs to the methyltransferase superfamily
WR52_RS07615	COG1199	ATP-dependent helicase activity
WR52_RS07620	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WR52_RS07630	COG0024	Methionine aminopeptidase
WR52_RS07640	COG2233	PERMEase
WR52_RS07645	COG2311	Membrane
WR52_RS07650	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
WR52_RS07660	COG0456	acetyltransferase
WR52_RS07710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WR52_RS07725	COG3944	biosynthesis protein
WR52_RS07735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WR52_RS07750	COG1215	transferase activity, transferring glycosyl groups
WR52_RS07755	COG0438	transferase activity, transferring glycosyl groups
WR52_RS07770	COG0454	-acetyltransferase
WR52_RS07790	COG0328	RNA-DNA hybrid ribonuclease activity
WR52_RS07825	COG3403	YqcI/YcgG family
WR52_RS07830	COG1280	lysine exporter protein (LysE YggA)
WR52_RS07850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WR52_RS07855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WR52_RS07865	COG0475	glutathione-regulated potassium exporter activity
WR52_RS07870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
WR52_RS07875	COG0789	Transcriptional regulator
WR52_RS07875	COG4978	Transcriptional regulator
WR52_RS07885	COG2323	membrane
WR52_RS07890	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WR52_RS07925	COG1923	regulation of RNA biosynthetic process
WR52_RS07935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WR52_RS07940	COG1360	Flagellar Motor Protein
WR52_RS07945	COG2201	protein-glutamate methylesterase activity
WR52_RS07950	COG0643	Histidine kinase
WR52_RS07950	COG2198	Histidine kinase
WR52_RS07955	COG1776	CheC inhibitor of MCP methylation
WR52_RS07955	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WR52_RS07970	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WR52_RS07990	COG1256	bacterial-type flagellum assembly
WR52_RS07995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WR52_RS08000	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
WR52_RS08015	COG1815	bacterial-type flagellum-dependent cell motility
WR52_RS08020	COG1558	bacterial-type flagellum-dependent cell motility
WR52_RS08030	COG1766	The M ring may be actively involved in energy transduction
WR52_RS08035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WR52_RS08045	COG1157	protein secretion by the type III secretion system
WR52_RS08080	COG0784	Response regulator, receiver
WR52_RS08080	COG0835	chemotaxis
WR52_RS08090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WR52_RS08095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WR52_RS08100	COG0741	lytic transglycosylase activity
WR52_RS08110	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WR52_RS08115	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WR52_RS08115	COG1776	CheC inhibitor of MCP methylation
WR52_RS08125	COG1338	Plays a role in the flagellum-specific transport system
WR52_RS08130	COG1987	bacterial-type flagellum assembly
WR52_RS08140	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WR52_RS08145	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WR52_RS08150	COG1419	protein localization to endoplasmic reticulum
WR52_RS08155	COG4786	Flagellar basal body rod
WR52_RS08160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WR52_RS08190	COG2329	Antibiotic biosynthesis monooxygenase
WR52_RS08215	COG0583	DNA-binding transcription factor activity
WR52_RS08235	COG1234	tRNA 3'-trailer cleavage
WR52_RS08260	COG0406	alpha-ribazole phosphatase activity
WR52_RS08290	COG0367	asparagine synthase
WR52_RS08320	COG1802	Transcriptional regulator
WR52_RS08325	COG0697	spore germination
WR52_RS08335	COG0523	cobalamin synthesis protein
WR52_RS08340	COG0701	Predicted permease
WR52_RS08355	COG1757	Na H antiporter
WR52_RS08360	COG0789	Transcriptional regulator
WR52_RS08385	COG0534	Mate efflux family protein
WR52_RS08390	COG3340	Belongs to the peptidase S51 family
WR52_RS08410	COG0785	Cytochrome C biogenesis protein
WR52_RS08425	COG0457	Tetratricopeptide repeat
WR52_RS08445	COG2733	membrane
WR52_RS08480	COG1131	(ABC) transporter
WR52_RS08495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WR52_RS08500	COG0528	UMP kinase activity
WR52_RS08510	COG1027	Aspartate ammonia-lyase
WR52_RS08515	COG0281	malic enzyme
WR52_RS08520	COG4191	Histidine kinase
WR52_RS08525	COG0784	Response regulator, receiver
WR52_RS08530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WR52_RS08580	COG2814	Major facilitator Superfamily
WR52_RS08595	COG1695	Transcriptional regulator
WR52_RS08610	COG0477	Major facilitator Superfamily
WR52_RS08620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WR52_RS08625	COG2223	nitrite transmembrane transporter activity
WR52_RS08630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WR52_RS08650	COG0733	neurotransmitter:sodium symporter activity
WR52_RS08660	COG5566	PFAM Mor transcription activator
WR52_RS08665	COG2323	membrane
WR52_RS08685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WR52_RS08695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WR52_RS08700	COG0028	Belongs to the TPP enzyme family
WR52_RS08720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WR52_RS08745	COG2814	Major facilitator Superfamily
WR52_RS08750	COG3384	dioxygenase
WR52_RS08760	COG3279	Response regulator of the LytR AlgR family
WR52_RS08765	COG0427	acetyl-CoA hydrolase
WR52_RS08785	COG4166	transmembrane transport
WR52_RS08790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_RS08795	COG1914	H( )-stimulated, divalent metal cation uptake system
WR52_RS08810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WR52_RS08820	COG0531	amino acid
WR52_RS08850	COG2309	aminopeptidase activity
WR52_RS08865	COG0456	acetyltransferase
WR52_RS08875	COG1266	CAAX protease self-immunity
WR52_RS08880	COG1309	transcriptional regulator
WR52_RS08885	COG2390	Transcriptional regulator
WR52_RS08895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_RS08900	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WR52_RS08910	COG4846	Membrane protein involved in cytochrome C biogenesis
WR52_RS08935	COG0006	proline dipeptidase activity
WR52_RS08945	COG2132	Multicopper oxidase
WR52_RS08960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WR52_RS08970	COG0798	PFAM Bile acid sodium symporter
WR52_RS08980	COG1114	Component of the transport system for branched-chain amino acids
WR52_RS08990	COG2372	response to copper ion
WR52_RS08990	COG1276	copper resistance
WR52_RS08995	COG4549	nuclear export factor GLE1
WR52_RS09000	COG0697	spore germination
WR52_RS09005	COG0583	DNA-binding transcription factor activity
WR52_RS09010	COG1959	2 iron, 2 sulfur cluster binding
WR52_RS09015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
WR52_RS09020	COG0778	Nitroreductase
WR52_RS09035	COG0628	permease
WR52_RS09045	COG1231	oxidoreductase activity
WR52_RS09050	COG0523	cobalamin synthesis protein
WR52_RS09060	COG0411	ABC transporter
WR52_RS09080	COG0583	DNA-binding transcription factor activity
WR52_RS09110	COG1271	oxidase subunit
WR52_RS09115	COG1294	oxidase, subunit
WR52_RS09120	COG4988	ABC transporter
WR52_RS09125	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WR52_RS09135	COG1216	Glycosyl transferase, family 2
WR52_RS09175	COG1686	Belongs to the peptidase S11 family
WR52_RS09190	COG1388	LysM domain
WR52_RS09190	COG0791	NLP P60 protein
WR52_RS09200	COG1132	(ABC) transporter
WR52_RS09205	COG0745	RESPONSE REGULATOR receiver
WR52_RS09210	COG5002	protein histidine kinase activity
WR52_RS09220	COG0300	oxidoreductase activity
WR52_RS09250	COG0460	homoserine dehydrogenase
WR52_RS09275	COG1316	TRANSCRIPTIONal
WR52_RS09285	COG0745	RESPONSE REGULATOR receiver
WR52_RS09290	COG5002	protein histidine kinase activity
WR52_RS09305	COG1285	pathogenesis
WR52_RS09310	COG1247	-acetyltransferase
WR52_RS09330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WR52_RS09340	COG1082	Xylose isomerase domain protein TIM barrel
WR52_RS09350	COG2814	Major facilitator Superfamily
WR52_RS09355	COG1279	arginine transmembrane transporter activity
WR52_RS09360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_RS09370	COG1752	Esterase of the alpha-beta hydrolase superfamily
WR52_RS09400	COG2801	Transposase and inactivated derivatives
WR52_RS09410	COG0577	efflux transmembrane transporter activity
WR52_RS09415	COG2002	toxin-antitoxin pair type II binding
WR52_RS09420	COG1404	Belongs to the peptidase S8 family
WR52_RS09425	COG0640	Transcriptional regulator
WR52_RS09430	COG0667	Aldo Keto reductase
WR52_RS09435	COG2814	Major facilitator Superfamily
WR52_RS09445	COG3152	Membrane
WR52_RS09470	COG0840	transmembrane signaling receptor activity
WR52_RS09485	COG3949	Membrane
WR52_RS09490	COG0783	Belongs to the Dps family
WR52_RS09505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WR52_RS09515	COG1231	oxidoreductase activity
WR52_RS09520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_RS09525	COG4989	oxidoreductase activity
WR52_RS09530	COG0523	cobalamin synthesis protein
WR52_RS09535	COG0456	acetyltransferase
WR52_RS09540	COG0803	Belongs to the bacterial solute-binding protein 9 family
WR52_RS09545	COG0702	epimerase
WR52_RS09555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WR52_RS09565	COG4166	transmembrane transport
WR52_RS09590	COG5337	Spore coat protein CotH
WR52_RS09595	COG1051	belongs to the nudix hydrolase family
WR52_RS09600	COG0586	Pfam SNARE associated Golgi protein
WR52_RS09605	COG2244	polysaccharide biosynthetic process
WR52_RS09615	COG0701	Predicted permease
WR52_RS09620	COG3689	TIGRFAM TIGR03943 family protein
WR52_RS09625	COG1607	acyl-coa hydrolase
WR52_RS09630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WR52_RS09645	COG0702	epimerase
WR52_RS09650	COG2839	Protein conserved in bacteria
WR52_RS09655	COG1253	flavin adenine dinucleotide binding
WR52_RS09670	COG1114	Component of the transport system for branched-chain amino acids
WR52_RS09675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WR52_RS09690	COG0860	N-Acetylmuramoyl-L-alanine amidase
WR52_RS09700	COG1876	peptidase activity
WR52_RS09710	COG2211	Major facilitator Superfamily
WR52_RS09725	COG0860	N-Acetylmuramoyl-L-alanine amidase
WR52_RS09735	COG0561	phosphatase activity
WR52_RS09750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WR52_RS09765	COG1819	glycosyl
WR52_RS09770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_RS09775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_RS09805	COG0456	acetyltransferase
WR52_RS09845	COG4499	WXG100 protein secretion system (Wss), protein YukC
WR52_RS09910	COG3874	Sporulation protein YtfJ
WR52_RS09935	COG2226	methyltransferase
WR52_RS09955	COG1082	Xylose isomerase domain protein TIM barrel
WR52_RS09960	COG0346	lactoylglutathione lyase activity
WR52_RS09970	COG0604	alcohol dehydrogenase
WR52_RS09975	COG1595	DNA-templated transcription, initiation
WR52_RS09990	COG0426	domain, Protein
WR52_RS09990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WR52_RS10000	COG0386	Belongs to the glutathione peroxidase family
WR52_RS10005	COG1305	Transglutaminase-like
WR52_RS10010	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
WR52_RS10015	COG0714	Associated with various cellular activities
WR52_RS10020	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
WR52_RS10025	COG1140	nitrate reductase beta subunit
WR52_RS10030	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
WR52_RS10035	COG2181	nitrate reductase activity
WR52_RS10040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WR52_RS10045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WR52_RS10050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WR52_RS10055	COG0303	'Molybdopterin
WR52_RS10060	COG0314	molybdopterin synthase activity
WR52_RS10070	COG2223	nitrite transmembrane transporter activity
WR52_RS10090	COG1648	precorrin-2 dehydrogenase activity
WR52_RS10100	COG1587	Uroporphyrinogen-III synthase
WR52_RS10100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WR52_RS10105	COG2146	nitrite reductase [NAD(P)H] activity
WR52_RS10110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WR52_RS10115	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
WR52_RS10135	COG2162	N-hydroxyarylamine O-acetyltransferase activity
WR52_RS10150	COG2359	stage V sporulation protein S
WR52_RS10175	COG0457	Tetratricopeptide repeat
WR52_RS10190	COG2856	Zn peptidase
WR52_RS10195	COG1396	sequence-specific DNA binding
WR52_RS10245	COG0662	Cupin 2, conserved barrel domain protein
WR52_RS10265	COG0582	viral genome integration into host DNA
WR52_RS10300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WR52_RS10310	COG5484	DNA packaging
WR52_RS10315	COG1783	phage Terminase large subunit
WR52_RS10330	COG0338	D12 class N6 adenine-specific DNA methyltransferase
WR52_RS10455	COG0457	Tetratricopeptide repeat
WR52_RS10495	COG1418	mRNA catabolic process
WR52_RS10500	COG0488	(ABC) transporter
WR52_RS10515	COG0629	single-stranded DNA binding
WR52_RS10520	COG1413	lyase activity
WR52_RS10535	COG2136	Putative SAM-dependent methyltransferase
WR52_RS10535	COG2521	methyltransferase
WR52_RS10540	COG0018	arginyl-trna synthetase
WR52_RS10585	COG0017	Asparaginyl-tRNA synthetase
WR52_RS10590	COG1929	Belongs to the glycerate kinase type-1 family
WR52_RS10600	COG0745	RESPONSE REGULATOR receiver
WR52_RS10605	COG5002	protein histidine kinase activity
WR52_RS10605	COG3850	Histidine kinase
WR52_RS10620	COG0733	neurotransmitter:sodium symporter activity
WR52_RS10645	COG2610	gluconate transmembrane transporter activity
WR52_RS10655	COG1794	racemase activity, acting on amino acids and derivatives
WR52_RS10665	COG0456	acetyltransferase
WR52_RS10675	COG3655	Transcriptional regulator
WR52_RS10680	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WR52_RS10695	COG4473	ABC transporter
WR52_RS10705	COG0546	phosphoglycolate phosphatase activity
WR52_RS10720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WR52_RS10735	COG0768	penicillin binding
WR52_RS10745	COG0204	Acyl-transferase
WR52_RS10750	COG1272	protein, Hemolysin III
WR52_RS10760	COG0805	protein transport
WR52_RS10770	COG1307	EDD domain protein, DegV family
WR52_RS10780	COG1999	signal sequence binding
WR52_RS10785	COG0071	Belongs to the small heat shock protein (HSP20) family
WR52_RS10790	COG0367	asparagine synthase
WR52_RS10805	COG0860	N-Acetylmuramoyl-L-alanine amidase
WR52_RS10810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_RS10815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WR52_RS10830	COG1335	isochorismatase
WR52_RS10895	COG2801	Transposase and inactivated derivatives
WR52_RS10900	COG0668	transmembrane transport
WR52_RS10905	COG4585	Histidine kinase
WR52_RS10905	COG2203	Gaf domain
WR52_RS10910	COG2197	response regulator
WR52_RS10915	COG1737	Transcriptional regulator
WR52_RS10920	COG0384	phenazine biosynthesis protein PhzF
WR52_RS10925	COG1064	alcohol dehydrogenase
WR52_RS10950	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
WR52_RS10985	COG1125	glycine betaine transport
WR52_RS10985	COG0517	IMP dehydrogenase activity
WR52_RS10990	COG1174	glycine betaine transport
WR52_RS11025	COG1253	flavin adenine dinucleotide binding
WR52_RS11030	COG1012	belongs to the aldehyde dehydrogenase family
WR52_RS11035	COG5506	Protein of unknown function (DUF1694)
WR52_RS11050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WR52_RS11055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WR52_RS11060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WR52_RS11065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WR52_RS11070	COG0456	acetyltransferase
WR52_RS11075	COG3829	transcription factor binding
WR52_RS11080	COG1509	lysine 2,3-aminomutase activity
WR52_RS11110	COG0515	serine threonine protein kinase
WR52_RS11110	COG3064	Membrane
WR52_RS11110	COG4991	sh3 domain protein
WR52_RS11120	COG0671	phosphoesterase, PA-phosphatase related
WR52_RS11125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
WR52_RS11130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WR52_RS11235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WR52_RS11235	COG4499	WXG100 protein secretion system (Wss), protein YukC
WR52_RS11245	COG2814	Major facilitator Superfamily
WR52_RS11250	COG4841	protein insertion into membrane
WR52_RS11255	COG0372	Belongs to the citrate synthase family
WR52_RS11260	COG2079	MmgE PrpD family protein
WR52_RS11265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WR52_RS11270	COG1960	acyl-CoA dehydrogenase activity
WR52_RS11275	COG2084	Dehydrogenase
WR52_RS11285	COG1280	lysine exporter protein (LysE YggA)
WR52_RS11290	COG1024	Enoyl-CoA hydratase
WR52_RS11305	COG0420	3'-5' exonuclease activity
WR52_RS11310	COG0419	ATPase involved in DNA repair
WR52_RS11330	COG2223	nitrite transmembrane transporter activity
WR52_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS11340	COG1169	isochorismate synthase
WR52_RS11345	COG1021	2,3-dihydroxybenzoate-AMP ligase
WR52_RS11350	COG3433	isochorismatase activity
WR52_RS11350	COG1535	isochorismatase
WR52_RS11355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WR52_RS11360	COG3251	PFAM MbtH domain protein
WR52_RS11365	COG2814	Major facilitator Superfamily
WR52_RS11380	COG0776	regulation of translation
WR52_RS11390	COG2318	DinB family
WR52_RS11400	COG1115	amino acid carrier protein
WR52_RS11420	COG1187	pseudouridine synthase activity
WR52_RS11425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WR52_RS11430	COG1136	(ABC) transporter
WR52_RS11480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WR52_RS11495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_RS11530	COG1247	-acetyltransferase
WR52_RS11555	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
WR52_RS11565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_RS11595	COG0583	DNA-binding transcription factor activity
WR52_RS11600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WR52_RS11620	COG0583	DNA-binding transcription factor activity
WR52_RS11625	COG2258	MOSC domain
WR52_RS11640	COG1132	(ABC) transporter
WR52_RS11645	COG1132	(ABC) transporter
WR52_RS11670	COG1396	sequence-specific DNA binding
WR52_RS11710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WR52_RS11715	COG1595	DNA-templated transcription, initiation
WR52_RS11740	COG1649	PFAM Uncharacterised BCR, COG1649
WR52_RS11765	COG2971	BadF BadG BcrA BcrD
WR52_RS11775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WR52_RS11785	COG1846	Transcriptional regulator
WR52_RS11800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_RS11825	COG1309	transcriptional regulator
WR52_RS11840	COG0500	methyltransferase
WR52_RS11840	COG3615	Tellurite resistance protein tehB
WR52_RS11850	COG2226	methyltransferase
WR52_RS11860	COG1846	Transcriptional regulator
WR52_RS11890	COG2195	Cleaves the N-terminal amino acid of tripeptides
WR52_RS11900	COG2801	Transposase and inactivated derivatives
WR52_RS11925	COG2002	toxin-antitoxin pair type II binding
WR52_RS11935	COG0730	response to heat
WR52_RS11940	COG0110	maltose O-acetyltransferase activity
WR52_RS11945	COG1686	Belongs to the peptidase S11 family
WR52_RS11950	COG2814	Major facilitator Superfamily
WR52_RS11985	COG2312	Erythromycin esterase
WR52_RS11990	COG0741	lytic transglycosylase activity
WR52_RS11995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_RS12010	COG0768	penicillin binding
WR52_RS12015	COG1595	DNA-templated transcription, initiation
WR52_RS12025	COG0768	penicillin binding
WR52_RS12030	COG0768	penicillin binding
WR52_RS12040	COG1408	metallophosphoesterase
WR52_RS12050	COG1131	(ABC) transporter
WR52_RS12060	COG1309	transcriptional regulator
WR52_RS12075	COG1960	acyl-CoA dehydrogenase activity
WR52_RS12080	COG0439	Biotin carboxylase
WR52_RS12085	COG0511	ligase activity, forming carbon-carbon bonds
WR52_RS12090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WR52_RS12095	COG1024	Enoyl-CoA hydratase
WR52_RS12100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WR52_RS12105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WR52_RS12125	COG0572	uridine kinase
WR52_RS12130	COG2318	DinB family
WR52_RS12135	COG1686	Belongs to the peptidase S11 family
WR52_RS12165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WR52_RS12185	COG3227	Zinc metalloprotease (Elastase)
WR52_RS12190	COG2207	Transcriptional regulator
WR52_RS12220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WR52_RS12240	COG2226	methyltransferase
WR52_RS12245	COG0596	Alpha beta hydrolase
WR52_RS12255	COG1942	4-Oxalocrotonate Tautomerase
WR52_RS12260	COG0583	DNA-binding transcription factor activity
WR52_RS12280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_RS12310	COG3386	PFAM SMP-30 Gluconolaconase
WR52_RS12315	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WR52_RS12330	COG0745	RESPONSE REGULATOR receiver
WR52_RS12335	COG2205	protein histidine kinase activity
WR52_RS12340	COG0488	(ABC) transporter
WR52_RS12350	COG1136	(ABC) transporter
WR52_RS12355	COG0577	efflux transmembrane transporter activity
WR52_RS12375	COG0460	homoserine dehydrogenase
WR52_RS12380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_RS12390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WR52_RS12415	COG0582	viral genome integration into host DNA
WR52_RS12450	COG2002	toxin-antitoxin pair type II binding
WR52_RS12495	COG0582	viral genome integration into host DNA
WR52_RS12505	COG0531	amino acid
WR52_RS12510	COG2801	Transposase and inactivated derivatives
WR52_RS12620	COG4824	toxin secretion phage lysis holin
WR52_RS12665	COG2124	cytochrome p450
WR52_RS12700	COG0561	phosphatase activity
WR52_RS12705	COG5002	protein histidine kinase activity
WR52_RS12710	COG0768	penicillin binding
WR52_RS12720	COG1819	glycosyl
WR52_RS12725	COG1794	racemase activity, acting on amino acids and derivatives
WR52_RS12745	COG2205	protein histidine kinase activity
WR52_RS12755	COG2801	Transposase and inactivated derivatives
WR52_RS12800	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
WR52_RS12805	COG0604	alcohol dehydrogenase
WR52_RS12810	COG0671	phosphoesterase, PA-phosphatase related
WR52_RS12815	COG0768	penicillin binding
WR52_RS12855	COG0693	protein deglycase activity
WR52_RS12870	COG0584	glycerophosphoryl diester phosphodiesterase
WR52_RS12890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_RS12895	COG0697	spore germination
WR52_RS12925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WR52_RS12935	COG2223	nitrite transmembrane transporter activity
WR52_RS12950	COG0592	DNA-directed DNA polymerase activity
WR52_RS12980	COG0251	oxidation-reduction process
WR52_RS12985	COG3878	Protein conserved in bacteria
WR52_RS13005	COG4667	esterase of the alpha-beta hydrolase superfamily
WR52_RS13045	COG0322	excinuclease ABC activity
WR52_RS13085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WR52_RS13120	COG1011	Hydrolase
WR52_RS13135	COG1073	alpha beta
WR52_RS13140	COG0657	acetylesterase activity
WR52_RS13145	COG0076	glutamate decarboxylase activity
WR52_RS13160	COG1523	belongs to the glycosyl hydrolase 13 family
WR52_RS13165	COG3227	Zinc metalloprotease (Elastase)
WR52_RS13170	COG0737	Belongs to the 5'-nucleotidase family
WR52_RS13190	COG0201	protein transport
WR52_RS13195	COG0697	spore germination
WR52_RS13200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_RS13205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WR52_RS13235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_RS13250	COG2959	enzyme of heme biosynthesis
WR52_RS13290	COG1309	transcriptional regulator
WR52_RS13320	COG3284	Transcriptional regulator
WR52_RS13335	COG1349	DNA-binding transcription factor activity
WR52_RS13350	COG1959	2 iron, 2 sulfur cluster binding
WR52_RS13365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WR52_RS13370	COG0508	dehydrogenase complex catalyzes the overall conversion of
WR52_RS13375	COG0022	dehydrogenase e1 component
WR52_RS13380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WR52_RS13390	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS13420	COG4176	ABC-type proline glycine betaine transport system permease component
WR52_RS13425	COG0517	IMP dehydrogenase activity
WR52_RS13425	COG4175	Glycine betaine
WR52_RS13455	COG2153	protein acetylation
WR52_RS13460	COG3397	chitin binding
WR52_RS13500	COG2205	protein histidine kinase activity
WR52_RS13505	COG2226	methyltransferase
WR52_RS13510	COG2315	Protein conserved in bacteria
WR52_RS13560	COG3973	AAA domain
WR52_RS13575	COG0514	ATP-dependent DNA helicase (RecQ)
WR52_RS13610	COG4637	Psort location Cytoplasmic, score
WR52_RS13625	COG3397	chitin binding
WR52_RS13640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WR52_RS13645	COG1115	amino acid carrier protein
WR52_RS13650	COG1012	belongs to the aldehyde dehydrogenase family
WR52_RS13655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WR52_RS13665	COG3938	Belongs to the proline racemase family
WR52_RS13670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WR52_RS13715	COG1078	dGTPase activity
WR52_RS13720	COG0586	Pfam SNARE associated Golgi protein
WR52_RS13730	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
WR52_RS13740	COG4166	transmembrane transport
WR52_RS13750	COG4948	Mandelate Racemase Muconate Lactonizing
WR52_RS13765	COG0667	Aldo Keto reductase
WR52_RS13810	COG3850	Histidine kinase
WR52_RS13810	COG5002	protein histidine kinase activity
WR52_RS13815	COG0745	RESPONSE REGULATOR receiver
WR52_RS13840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WR52_RS13850	COG1164	Oligoendopeptidase f
WR52_RS13855	COG1307	EDD domain protein, DegV family
WR52_RS13880	COG2814	Major facilitator Superfamily
WR52_RS13890	COG1664	Polymer-forming cytoskeletal
WR52_RS13895	COG0789	Transcriptional regulator
WR52_RS13900	COG4533	DNA binding
WR52_RS13905	COG0477	Major facilitator Superfamily
WR52_RS13905	COG2814	Major facilitator Superfamily
WR52_RS13925	COG2261	transglycosylase associated protein
WR52_RS13940	COG2226	methyltransferase
WR52_RS13960	COG2801	Transposase and inactivated derivatives
WR52_RS13985	COG0436	Aminotransferase
WR52_RS13990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WR52_RS14000	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
WR52_RS14015	COG1131	(ABC) transporter
WR52_RS14020	COG2188	Transcriptional regulator
WR52_RS14065	COG0628	permease
WR52_RS14080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WR52_RS14125	COG2746	aminoglycoside 3-N-acetyltransferase activity
WR52_RS14135	COG0697	spore germination
WR52_RS14155	COG4912	Dna alkylation repair
WR52_RS14160	COG0346	lactoylglutathione lyase activity
WR52_RS14175	COG0861	Integral membrane protein TerC family
WR52_RS14180	COG1368	sulfuric ester hydrolase activity
WR52_RS14185	COG0488	(ABC) transporter
WR52_RS14190	COG2409	Drug exporters of the RND superfamily
WR52_RS14190	COG1033	growth of symbiont in host cell
WR52_RS14195	COG1309	transcriptional regulator
WR52_RS14210	COG0287	Prephenate dehydrogenase
WR52_RS14225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
WR52_RS14225	COG1605	Chorismate mutase
WR52_RS14270	COG3584	3D domain protein
WR52_RS14270	COG1388	LysM domain
WR52_RS14280	COG0346	lactoylglutathione lyase activity
WR52_RS14320	COG1172	Belongs to the binding-protein-dependent transport system permease family
WR52_RS14330	COG2390	Transcriptional regulator
WR52_RS14335	COG1070	Carbohydrate kinase
WR52_RS14350	COG2329	Antibiotic biosynthesis monooxygenase
WR52_RS14370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_RS14385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WR52_RS14390	COG4187	Peptidase family M20/M25/M40
WR52_RS14395	COG1414	Transcriptional regulator
WR52_RS14400	COG0833	amino acid
WR52_RS14410	COG3239	Fatty acid desaturase
WR52_RS14420	COG2720	vancomycin resistance protein
WR52_RS14425	COG1785	Belongs to the alkaline phosphatase family
WR52_RS14435	COG3655	Transcriptional regulator
WR52_RS14455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_RS14460	COG0346	lactoylglutathione lyase activity
WR52_RS14485	COG0714	Associated with various cellular activities
WR52_RS14510	COG0463	Glycosyl transferase, family 2
WR52_RS14545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WR52_RS14550	COG0753	catalase activity
WR52_RS14570	COG2801	Transposase and inactivated derivatives
WR52_RS14600	COG0714	Associated with various cellular activities
WR52_RS14700	COG0778	Nitroreductase
WR52_RS14705	COG1846	Transcriptional regulator
WR52_RS14725	COG0179	Fumarylacetoacetate (FAA) hydrolase
WR52_RS14735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WR52_RS14740	COG0824	Thioesterase
WR52_RS14745	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_RS14750	COG0183	Belongs to the thiolase family
WR52_RS14755	COG1024	Enoyl-CoA hydratase
WR52_RS14760	COG1250	3-hydroxyacyl-CoA dehydrogenase
WR52_RS14770	COG2508	Transcriptional regulator
WR52_RS14775	COG2814	Major facilitator Superfamily
WR52_RS14780	COG1574	metal-dependent hydrolase with the TIM-barrel fold
WR52_RS14815	COG0456	acetyltransferase
WR52_RS14830	COG0697	spore germination
WR52_RS14835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_RS14875	COG0730	response to heat
WR52_RS14885	COG0833	amino acid
WR52_RS14895	COG4335	DNA alkylation repair
WR52_RS14920	COG0768	penicillin binding
WR52_RS14950	COG1984	allophanate hydrolase subunit 2
WR52_RS14955	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
WR52_RS14960	COG1414	Transcriptional regulator
WR52_RS14970	COG3142	Participates in the control of copper homeostasis
WR52_RS14975	COG0640	Transcriptional regulator
WR52_RS14985	COG1960	acyl-CoA dehydrogenase activity
WR52_RS15000	COG3314	Sporulation integral membrane protein YlbJ
WR52_RS15020	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
WR52_RS15040	COG0574	Belongs to the PEP-utilizing enzyme family
WR52_RS15040	COG3848	Pyruvate phosphate dikinase
WR52_RS15045	COG2267	carboxylic ester hydrolase activity
WR52_RS15060	COG1124	(ABC) transporter
WR52_RS15065	COG0444	Belongs to the ABC transporter superfamily
WR52_RS15070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WR52_RS15075	COG0601	transmembrane transport
WR52_RS15080	COG0747	negative chemotaxis
WR52_RS15100	COG0596	Alpha beta hydrolase
WR52_RS15105	COG4990	cell redox homeostasis
WR52_RS15110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_RS15125	COG5577	PFAM Coat F domain
WR52_RS15130	COG3403	YqcI/YcgG family
WR52_RS15135	COG1280	lysine exporter protein (LysE YggA)
WR52_RS15140	COG1113	amino acid transport
WR52_RS15165	COG1063	alcohol dehydrogenase
WR52_RS15170	COG1027	Aspartate ammonia-lyase
WR52_RS15175	COG0252	asparaginase activity
WR52_RS15180	COG1396	sequence-specific DNA binding
WR52_RS15200	COG5002	protein histidine kinase activity
WR52_RS15225	COG2207	Transcriptional regulator
WR52_RS15235	COG0322	excinuclease ABC activity
WR52_RS15240	COG0531	amino acid
WR52_RS15245	COG1114	Component of the transport system for branched-chain amino acids
WR52_RS15250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WR52_RS15260	COG0281	malic enzyme
WR52_RS15275	COG0531	amino acid
WR52_RS15280	COG0697	spore germination
WR52_RS15285	COG0784	Response regulator, receiver
WR52_RS15290	COG4191	Histidine kinase
WR52_RS15300	COG1115	amino acid carrier protein
WR52_RS15335	COG0737	Belongs to the 5'-nucleotidase family
WR52_RS15340	COG2267	carboxylic ester hydrolase activity
WR52_RS15345	COG1335	isochorismatase
WR52_RS15365	COG0583	DNA-binding transcription factor activity
WR52_RS15370	COG1846	Transcriptional regulator
WR52_RS15375	COG0598	Magnesium transport protein CorA
WR52_RS15395	COG1073	alpha beta
WR52_RS15415	COG0415	Belongs to the DNA photolyase family
WR52_RS15420	COG0288	reversible hydration of carbon dioxide
WR52_RS15430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WR52_RS15435	COG5609	conserved protein (DUF2294)
WR52_RS15445	COG0456	acetyltransferase
WR52_RS15450	COG1575	Belongs to the MenA family. Type 1 subfamily
WR52_RS15460	COG0798	PFAM Bile acid sodium symporter
WR52_RS15465	COG0346	lactoylglutathione lyase activity
WR52_RS15470	COG0640	Transcriptional regulator
WR52_RS15495	COG0745	RESPONSE REGULATOR receiver
WR52_RS15525	COG2814	Major facilitator Superfamily
WR52_RS15535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WR52_RS15535	COG3320	Male sterility
WR52_RS15540	COG1309	transcriptional regulator
WR52_RS15545	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS15550	COG1522	sequence-specific DNA binding
WR52_RS15565	COG0346	lactoylglutathione lyase activity
WR52_RS15605	COG0814	amino acid
WR52_RS15620	COG5632	N-Acetylmuramoyl-L-alanine amidase
WR52_RS15620	COG3409	Peptidoglycan-binding domain 1 protein
WR52_RS15625	COG0583	DNA-binding transcription factor activity
WR52_RS15665	COG0745	RESPONSE REGULATOR receiver
WR52_RS15670	COG5002	protein histidine kinase activity
WR52_RS15670	COG3850	Histidine kinase
WR52_RS15720	COG2814	Major facilitator Superfamily
WR52_RS15730	COG2515	1-aminocyclopropane-1-carboxylate deaminase
WR52_RS15745	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
WR52_RS15765	COG0577	efflux transmembrane transporter activity
WR52_RS15785	COG3850	Histidine kinase
WR52_RS15785	COG5002	protein histidine kinase activity
WR52_RS15795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_RS15800	COG5002	protein histidine kinase activity
WR52_RS15805	COG0745	RESPONSE REGULATOR receiver
WR52_RS15810	COG4990	cell redox homeostasis
WR52_RS15820	COG1619	proteins homologs of microcin C7 resistance protein MccF
WR52_RS15830	COG0673	inositol 2-dehydrogenase activity
WR52_RS15835	COG0561	phosphatase activity
WR52_RS15845	COG1609	Transcriptional regulator
WR52_RS15850	COG0457	Tetratricopeptide repeat
WR52_RS15880	COG0534	Mate efflux family protein
WR52_RS15890	COG2814	Major facilitator Superfamily
WR52_RS15895	COG1309	transcriptional regulator
WR52_RS15900	COG1522	sequence-specific DNA binding
WR52_RS15905	COG0531	amino acid
WR52_RS15920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WR52_RS15940	COG0662	Cupin 2, conserved barrel domain protein
WR52_RS15945	COG2207	Transcriptional regulator
WR52_RS15945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_RS15960	COG3409	Peptidoglycan-binding domain 1 protein
WR52_RS15960	COG5632	N-Acetylmuramoyl-L-alanine amidase
WR52_RS16060	COG5444	nuclease activity
WR52_RS16075	COG2849	repeat protein
WR52_RS16080	COG5444	nuclease activity
WR52_RS16120	COG1876	peptidase activity
WR52_RS16125	COG2843	Capsule synthesis protein
WR52_RS16135	COG0477	Major facilitator Superfamily
WR52_RS16150	COG1846	Transcriptional regulator
WR52_RS16155	COG2814	Major facilitator Superfamily
WR52_RS16165	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
WR52_RS16170	COG1131	(ABC) transporter
WR52_RS16190	COG2076	Multidrug Resistance protein
WR52_RS16195	COG1309	transcriptional regulator
WR52_RS16210	COG2801	Transposase and inactivated derivatives
WR52_RS16225	COG2031	fatty acid transporter
WR52_RS16235	COG2249	NAD(P)H dehydrogenase (quinone) activity
WR52_RS16285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WR52_RS16290	COG1288	antiporter activity
WR52_RS16295	COG2356	endonuclease I
WR52_RS16315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WR52_RS16335	COG1733	regulation of RNA biosynthetic process
WR52_RS16340	COG0778	Nitroreductase
WR52_RS16350	COG0469	pyruvate kinase activity
WR52_RS16370	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS16380	COG1131	(ABC) transporter
WR52_RS16405	COG1011	Hydrolase
WR52_RS16410	COG2365	Tyrosine phosphatase family
WR52_RS16445	COG0628	permease
WR52_RS16505	COG1253	flavin adenine dinucleotide binding
WR52_RS16510	COG0789	Transcriptional regulator
WR52_RS16520	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WR52_RS16545	COG0697	spore germination
WR52_RS16555	COG1357	PFAM Pentapeptide repeats (8 copies)
WR52_RS16560	COG3813	Protein conserved in bacteria
WR52_RS16565	COG2706	6-phosphogluconolactonase activity
WR52_RS16570	COG1070	Carbohydrate kinase
WR52_RS16580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WR52_RS16585	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
WR52_RS16595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
WR52_RS16600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
WR52_RS16605	COG0604	alcohol dehydrogenase
WR52_RS16610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WR52_RS16615	COG0604	alcohol dehydrogenase
WR52_RS16625	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS16640	COG0840	transmembrane signaling receptor activity
WR52_RS16650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WR52_RS16650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WR52_RS16655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WR52_RS16655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WR52_RS16660	COG1733	regulation of RNA biosynthetic process
WR52_RS16680	COG2801	Transposase and inactivated derivatives
WR52_RS16685	COG0656	L-ascorbic acid biosynthetic process
WR52_RS16690	COG2814	Major facilitator Superfamily
WR52_RS16710	COG1846	Transcriptional regulator
WR52_RS16715	COG0814	amino acid
WR52_RS16745	COG1733	regulation of RNA biosynthetic process
WR52_RS16750	COG2188	Transcriptional regulator
WR52_RS16755	COG0673	inositol 2-dehydrogenase activity
WR52_RS16760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WR52_RS16765	COG1733	regulation of RNA biosynthetic process
WR52_RS16770	COG1733	regulation of RNA biosynthetic process
WR52_RS16790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_RS16810	COG0384	phenazine biosynthesis protein PhzF
WR52_RS16815	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_RS16820	COG2249	NAD(P)H dehydrogenase (quinone) activity
WR52_RS16825	COG1733	regulation of RNA biosynthetic process
WR52_RS16830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WR52_RS16850	COG2801	Transposase and inactivated derivatives
WR52_RS16870	COG1191	sigma factor activity
WR52_RS16930	COG1151	hydroxylamine reductase activity
WR52_RS16940	COG3757	hydrolase, family 25
WR52_RS16940	COG3409	Peptidoglycan-binding domain 1 protein
WR52_RS16975	COG2072	flavoprotein involved in K transport
WR52_RS17010	COG1113	amino acid transport
WR52_RS17015	COG2814	Major facilitator Superfamily
WR52_RS17050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WR52_RS17055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WR52_RS17065	COG1247	-acetyltransferase
WR52_RS17070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_RS17075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_RS17080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_RS17085	COG3739	integral membrane protein
WR52_RS17120	COG0583	DNA-binding transcription factor activity
WR52_RS17140	COG1193	negative regulation of DNA recombination
WR52_RS17155	COG2162	N-hydroxyarylamine O-acetyltransferase activity
WR52_RS17160	COG1164	Oligoendopeptidase f
WR52_RS17165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WR52_RS17190	COG0584	glycerophosphoryl diester phosphodiesterase
WR52_RS17200	COG0640	Transcriptional regulator
WR52_RS17205	COG0604	alcohol dehydrogenase
WR52_RS17215	COG0457	Tetratricopeptide repeat
WR52_RS17225	COG2808	Putative FMN-binding domain
WR52_RS17230	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
WR52_RS17240	COG0277	FAD linked oxidase domain protein
WR52_RS17275	COG3852	Histidine kinase
WR52_RS17285	COG1285	pathogenesis
WR52_RS17295	COG2514	catechol 2,3-dioxygenase activity
WR52_RS17300	COG2720	vancomycin resistance protein
WR52_RS17335	COG0716	FMN binding
WR52_RS17345	COG0494	nUDIX hydrolase
WR52_RS17365	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS17375	COG0165	Argininosuccinate lyase
WR52_RS17390	COG4145	pantothenate transmembrane transporter activity
WR52_RS17400	COG1012	belongs to the aldehyde dehydrogenase family
WR52_RS17405	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS17415	COG1657	PFAM Prenyltransferase squalene oxidase
WR52_RS17420	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
WR52_RS17425	COG2962	Rard protein
WR52_RS17430	COG3326	Membrane
WR52_RS17445	COG0489	protein tyrosine kinase activity
WR52_RS17455	COG0314	molybdopterin synthase activity
WR52_RS17460	COG0303	'Molybdopterin
WR52_RS17465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WR52_RS17470	COG2116	formate transmembrane transporter activity
WR52_RS17480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WR52_RS17485	COG5609	conserved protein (DUF2294)
WR52_RS17490	COG2427	Protein of unknown function (DUF1641)
WR52_RS17495	COG3383	formate dehydrogenase (NAD+) activity
WR52_RS17500	COG0697	spore germination
WR52_RS17545	COG2226	methyltransferase
WR52_RS17550	COG4166	transmembrane transport
WR52_RS17560	COG4166	transmembrane transport
WR52_RS17565	COG1301	dicarboxylic acid transport
WR52_RS17570	COG1316	TRANSCRIPTIONal
WR52_RS17580	COG1595	DNA-templated transcription, initiation
WR52_RS17590	COG1131	(ABC) transporter
WR52_RS17610	COG0673	inositol 2-dehydrogenase activity
WR52_RS17615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WR52_RS17620	COG0187	DNA topoisomerase II activity
WR52_RS17625	COG1832	CoA-binding protein
WR52_RS17630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WR52_RS17635	COG0745	RESPONSE REGULATOR receiver
WR52_RS17655	COG4841	protein insertion into membrane
WR52_RS17660	COG0824	Thioesterase
WR52_RS17690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WR52_RS17705	COG1132	(ABC) transporter
WR52_RS17710	COG1132	(ABC) transporter
WR52_RS17715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WR52_RS17745	COG2211	Major facilitator Superfamily
WR52_RS17755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WR52_RS17770	COG0183	Belongs to the thiolase family
WR52_RS17775	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_RS17780	COG1268	BioY protein
WR52_RS17785	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_RS17825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_RS17835	COG5002	protein histidine kinase activity
WR52_RS17840	COG0400	carboxylic ester hydrolase activity
WR52_RS17845	COG0346	lactoylglutathione lyase activity
WR52_RS17850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WR52_RS17855	COG0069	glutamate synthase activity
WR52_RS17860	COG1902	pentaerythritol trinitrate reductase activity
WR52_RS17865	COG1329	Transcriptional regulator
WR52_RS17870	COG0010	Belongs to the arginase family
WR52_RS17920	COG4846	Membrane protein involved in cytochrome C biogenesis
WR52_RS17925	COG0785	Cytochrome C biogenesis protein
WR52_RS17935	COG1473	amidohydrolase
WR52_RS17945	COG1131	(ABC) transporter
WR52_RS17960	COG0583	DNA-binding transcription factor activity
WR52_RS17970	COG1346	cytolysis
WR52_RS17985	COG0730	response to heat
WR52_RS18010	COG1132	(ABC) transporter
WR52_RS18015	COG1132	(ABC) transporter
WR52_RS18040	COG3639	organic phosphonate transmembrane transporter activity
WR52_RS18050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WR52_RS18055	COG0737	Belongs to the 5'-nucleotidase family
WR52_RS18065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WR52_RS18085	COG1695	Transcriptional regulator
WR52_RS18095	COG3409	Peptidoglycan-binding domain 1 protein
WR52_RS18095	COG5632	N-Acetylmuramoyl-L-alanine amidase
WR52_RS18095	COG1388	LysM domain
WR52_RS18100	COG0739	heme binding
WR52_RS18135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WR52_RS18140	COG0174	glutamine synthetase
WR52_RS18145	COG0789	Transcriptional regulator
WR52_RS18150	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
WR52_RS18155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WR52_RS18160	COG2860	membrane
WR52_RS18170	COG0464	growth
WR52_RS18190	COG2801	Transposase and inactivated derivatives
WR52_RS18210	COG3584	3D domain protein
WR52_RS18210	COG1388	LysM domain
WR52_RS18215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WR52_RS18215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WR52_RS18215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WR52_RS18220	COG1105	Belongs to the carbohydrate kinase PfkB family
WR52_RS18225	COG1349	DNA-binding transcription factor activity
WR52_RS18230	COG1979	alcohol dehydrogenase
WR52_RS18235	COG2322	membrane
WR52_RS18250	COG1113	amino acid transport
WR52_RS18260	COG1408	metallophosphoesterase
WR52_RS18265	COG2116	formate transmembrane transporter activity
WR52_RS18280	COG2217	Heavy metal translocating P-type atpase
WR52_RS18285	COG2608	mercury ion transmembrane transporter activity
WR52_RS18290	COG1937	Protein conserved in bacteria
WR52_RS18300	COG2819	hydrolase of the alpha beta superfamily
WR52_RS18305	COG1120	ATPase activity
WR52_RS18310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_RS18315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_RS18320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_RS18325	COG0708	Exodeoxyribonuclease III
WR52_RS18330	COG2169	Transcriptional regulator
WR52_RS18335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WR52_RS18340	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
WR52_RS18350	COG2364	Membrane
WR52_RS18365	COG2267	carboxylic ester hydrolase activity
WR52_RS18370	COG5001	Diguanylate cyclase
WR52_RS18370	COG3300	MHYT domain
WR52_RS18390	COG1086	Polysaccharide biosynthesis protein
WR52_RS18410	COG1346	cytolysis
WR52_RS18420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_RS18430	COG2188	Transcriptional regulator
WR52_RS18435	COG2723	6-phospho-beta-galactosidase activity
WR52_RS18445	COG1404	Belongs to the peptidase S8 family
WR52_RS18450	COG3773	Cell wall hydrolase
WR52_RS18460	COG1368	sulfuric ester hydrolase activity
WR52_RS18465	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
WR52_RS18490	COG4550	Control of competence regulator ComK, YlbF/YmcA
WR52_RS18500	COG1013	pyruvate-flavodoxin oxidoreductase activity
WR52_RS18505	COG0674	pyruvate-flavodoxin oxidoreductase activity
WR52_RS18505	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WR52_RS18515	COG2359	stage V sporulation protein S
WR52_RS18520	COG1692	metallophosphoesterase
WR52_RS18545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WR52_RS18550	COG1426	Protein conserved in bacteria
WR52_RS18565	COG0300	oxidoreductase activity
WR52_RS18570	COG0612	Peptidase, M16
WR52_RS18575	COG0612	Peptidase, M16
WR52_RS18580	COG1079	Belongs to the binding-protein-dependent transport system permease family
WR52_RS18585	COG4603	Belongs to the binding-protein-dependent transport system permease family
WR52_RS18590	COG3845	ABC transporter
WR52_RS18595	COG1744	ABC transporter substrate-binding protein PnrA-like
WR52_RS18600	COG2188	Transcriptional regulator
WR52_RS18615	COG0740	serine-type endopeptidase activity
WR52_RS18620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
WR52_RS18630	COG0527	aspartate kinase activity
WR52_RS18635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WR52_RS18640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WR52_RS18765	COG0582	viral genome integration into host DNA
WR52_RS18775	COG2801	Transposase and inactivated derivatives
WR52_RS18785	COG0791	NLP P60 protein
WR52_RS18785	COG1388	LysM domain
WR52_RS18790	COG3584	3D domain protein
WR52_RS18790	COG1388	LysM domain
WR52_RS18810	COG0305	Participates in initiation and elongation during chromosome replication
WR52_RS18845	COG3620	sequence-specific DNA binding
WR52_RS18870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WR52_RS18875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WR52_RS18880	COG1873	PFAM PRC-barrel domain
WR52_RS18885	COG0612	Peptidase, M16
WR52_RS18890	COG0726	polysaccharide deacetylase
WR52_RS18905	COG0196	riboflavin kinase activity
WR52_RS18915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WR52_RS18920	COG1550	Protein conserved in bacteria
WR52_RS18930	COG1358	cellular component organization or biogenesis
WR52_RS18935	COG2740	Nucleic-acid-binding protein implicated in transcription termination
WR52_RS18940	COG0195	Participates in both transcription termination and antitermination
WR52_RS18960	COG0750	zinc metalloprotease
WR52_RS18970	COG4589	Belongs to the CDS family
WR52_RS19015	COG4974	Belongs to the 'phage' integrase family
WR52_RS19025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WR52_RS19030	COG0758	DNA mediated transformation
WR52_RS19035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WR52_RS19075	COG1837	Belongs to the UPF0109 family
WR52_RS19085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WR52_RS19095	COG0552	protein localization to endoplasmic reticulum
WR52_RS19100	COG1196	nuclear chromosome segregation
WR52_RS19110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WR52_RS19115	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS19120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WR52_RS19135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WR52_RS19140	COG1461	Dihydroxyacetone kinase
WR52_RS19145	COG1302	Protein conserved in bacteria
WR52_RS19160	COG1564	THIamine pyrophosphokinase
WR52_RS19165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WR52_RS19175	COG0515	serine threonine protein kinase
WR52_RS19175	COG2815	serine threonine protein kinase
WR52_RS19180	COG0631	protein serine/threonine phosphatase activity
WR52_RS19190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WR52_RS19190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WR52_RS19205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WR52_RS19210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WR52_RS19230	COG1561	YicC-like family, N-terminal region
WR52_RS19235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WR52_RS19245	COG0006	proline dipeptidase activity
WR52_RS19265	COG3069	C4-dicarboxylate transmembrane transporter activity
WR52_RS19325	COG0564	pseudouridine synthase activity
WR52_RS19345	COG3599	regulation of cell shape
WR52_RS19350	COG2302	S4 RNA-binding domain
WR52_RS19355	COG0762	integral membrane protein
WR52_RS19365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WR52_RS19375	COG1873	PFAM PRC-barrel domain
WR52_RS19380	COG1191	sigma factor activity
WR52_RS19385	COG1191	sigma factor activity
WR52_RS19395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WR52_RS19400	COG0849	cell division
WR52_RS19420	COG0772	Belongs to the SEDS family
WR52_RS19440	COG0768	penicillin binding
WR52_RS19445	COG0768	penicillin binding
WR52_RS19465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WR52_RS19480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WR52_RS19485	COG1399	metal-binding, possibly nucleic acid-binding protein
WR52_RS19595	COG0740	serine-type endopeptidase activity
WR52_RS19605	COG4626	Terminase
WR52_RS19605	COG1802	Transcriptional regulator
WR52_RS19640	COG1674	ftsk spoiiie
WR52_RS19640	COG4980	gas vesicle protein
WR52_RS19645	COG0582	viral genome integration into host DNA
WR52_RS19700	COG2002	toxin-antitoxin pair type II binding
WR52_RS19720	COG1396	sequence-specific DNA binding
WR52_RS19755	COG0582	viral genome integration into host DNA
WR52_RS19765	COG3480	Lon protease (S16) C-terminal proteolytic domain
WR52_RS19770	COG1752	Esterase of the alpha-beta hydrolase superfamily
WR52_RS19775	COG3314	Sporulation integral membrane protein YlbJ
WR52_RS19785	COG0742	ribosomal rna small subunit methyltransferase
WR52_RS19800	COG3679	Belongs to the UPF0342 family
WR52_RS19805	COG0406	alpha-ribazole phosphatase activity
WR52_RS19820	COG2340	Cysteine-rich secretory protein family
WR52_RS19835	COG3336	cytochrome c oxidase
WR52_RS19870	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
WR52_RS19875	COG0772	Belongs to the SEDS family
WR52_RS19885	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WR52_RS19890	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WR52_RS19900	COG4896	Protein conserved in bacteria
WR52_RS19915	COG1217	gtp-binding protein TYPA
WR52_RS19925	COG0483	inositol monophosphate 1-phosphatase activity
WR52_RS19945	COG1982	Orn Lys Arg decarboxylase major
WR52_RS19995	COG0022	dehydrogenase e1 component
WR52_RS20000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WR52_RS20015	COG0561	phosphatase activity
WR52_RS20025	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
WR52_RS20030	COG0569	domain protein
WR52_RS20050	COG0583	DNA-binding transcription factor activity
WR52_RS20055	COG0517	IMP dehydrogenase activity
WR52_RS20065	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
WR52_RS20075	COG4703	Protein of unknown function (DUF1797)
WR52_RS20090	COG2200	EAL domain
WR52_RS20095	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS20100	COG1408	metallophosphoesterase
WR52_RS20145	COG2814	Major facilitator Superfamily
WR52_RS20165	COG3209	COG3209 Rhs family protein
WR52_RS20175	COG2205	protein histidine kinase activity
WR52_RS20185	COG0436	Aminotransferase
WR52_RS20190	COG1609	Transcriptional regulator
WR52_RS20195	COG3833	ABC-type maltose transport systems, permease component
WR52_RS20200	COG1175	transmembrane transport
WR52_RS20205	COG2182	Extracellular solute-binding protein
WR52_RS20215	COG0366	Alpha amylase catalytic
WR52_RS20220	COG3842	ATPase activity
WR52_RS20260	COG0183	Belongs to the thiolase family
WR52_RS20290	COG1695	Transcriptional regulator
WR52_RS20295	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS20315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WR52_RS20320	COG0436	Aminotransferase
WR52_RS20355	COG2084	Dehydrogenase
WR52_RS20365	COG2199	diguanylate cyclase activity
WR52_RS20370	COG0778	Nitroreductase
WR52_RS20395	COG2190	(PTS) system
WR52_RS20395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_RS20395	COG1263	PTS System
WR52_RS20400	COG3711	transcriptional antiterminator
WR52_RS20410	COG2188	Transcriptional regulator
WR52_RS20420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WR52_RS20445	COG1547	Domain of unknown function (DUF309)
WR52_RS20450	COG0456	acetyltransferase
WR52_RS20455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WR52_RS20460	COG4086	secreted protein
WR52_RS20465	COG0561	phosphatase activity
WR52_RS20470	COG0697	spore germination
WR52_RS20485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WR52_RS20510	COG0733	neurotransmitter:sodium symporter activity
WR52_RS20530	COG1686	Belongs to the peptidase S11 family
WR52_RS20535	COG1725	Transcriptional regulator
WR52_RS20540	COG1131	(ABC) transporter
WR52_RS20560	COG1846	Transcriptional regulator
WR52_RS20575	COG0598	Magnesium transport protein CorA
WR52_RS20600	COG4974	Belongs to the 'phage' integrase family
WR52_RS20610	COG0735	belongs to the Fur family
WR52_RS20615	COG1300	Membrane
WR52_RS20635	COG0667	Aldo Keto reductase
WR52_RS20640	COG0656	L-ascorbic acid biosynthetic process
WR52_RS20645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
WR52_RS20645	COG0456	acetyltransferase
WR52_RS20655	COG4085	toxin activity
WR52_RS20655	COG1525	nuclease
WR52_RS20655	COG0737	Belongs to the 5'-nucleotidase family
WR52_RS20665	COG0596	Alpha beta hydrolase
WR52_RS20670	COG2056	Na+-H+ antiporter family
WR52_RS20675	COG1609	Transcriptional regulator
WR52_RS20680	COG0456	acetyltransferase
WR52_RS20685	COG1073	alpha beta
WR52_RS20700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WR52_RS20700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WR52_RS20705	COG0307	riboflavin synthase, alpha
WR52_RS20735	COG1073	alpha beta
WR52_RS20735	COG2226	methyltransferase
WR52_RS20750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WR52_RS20760	COG1757	Na H antiporter
WR52_RS20765	COG0737	Belongs to the 5'-nucleotidase family
WR52_RS20775	COG1522	sequence-specific DNA binding
WR52_RS20820	COG0300	oxidoreductase activity
WR52_RS20825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_RS20830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WR52_RS20835	COG2801	Transposase and inactivated derivatives
WR52_RS20845	COG1760	l-serine dehydratase
WR52_RS20850	COG1760	l-serine dehydratase
WR52_RS20880	COG2195	Cleaves the N-terminal amino acid of tripeptides
WR52_RS20885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_RS20895	COG1376	ErfK ybiS ycfS ynhG family protein
WR52_RS20900	COG4129	membrane
WR52_RS20905	COG1126	abc transporter atp-binding protein
WR52_RS20910	COG0765	amino acid transport
WR52_RS20915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WR52_RS20940	COG0772	Belongs to the SEDS family
WR52_RS20945	COG0508	dehydrogenase complex catalyzes the overall conversion of
WR52_RS20950	COG0022	dehydrogenase e1 component
WR52_RS20955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WR52_RS20960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WR52_RS20975	COG0280	phosphate acetyltransferase
WR52_RS20980	COG3290	protein histidine kinase activity
WR52_RS20980	COG3829	transcription factor binding
WR52_RS20990	COG0584	glycerophosphoryl diester phosphodiesterase
WR52_RS20995	COG3093	addiction module antidote protein HigA
WR52_RS21010	COG0750	zinc metalloprotease
WR52_RS21015	COG0497	DNA recombination
WR52_RS21025	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WR52_RS21035	COG0142	geranyltranstransferase activity
WR52_RS21060	COG1302	Protein conserved in bacteria
WR52_RS21065	COG0439	Biotin carboxylase
WR52_RS21070	COG0511	ligase activity, forming carbon-carbon bonds
WR52_RS21110	COG3854	ATPases associated with a variety of cellular activities
WR52_RS21135	COG0006	proline dipeptidase activity
WR52_RS21150	COG3872	metal-dependent enzyme
WR52_RS21160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WR52_RS21175	COG1695	Transcriptional regulator
WR52_RS21195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WR52_RS21205	COG1609	Transcriptional regulator
WR52_RS21215	COG2076	Multidrug Resistance protein
WR52_RS21220	COG2076	Multidrug Resistance protein
WR52_RS21250	COG1131	(ABC) transporter
WR52_RS21255	COG1725	Transcriptional regulator
WR52_RS21285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WR52_RS21350	COG1459	type II secretion system
WR52_RS21355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WR52_RS21410	COG1410	methionine synthase
WR52_RS21410	COG0646	methionine synthase
WR52_RS21415	COG0646	methionine synthase
WR52_RS21415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
WR52_RS21420	COG0626	cystathionine gamma-synthase activity
WR52_RS21425	COG0626	cystathionine gamma-synthase activity
WR52_RS21445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_RS21450	COG1940	carbohydrate kinase activity
WR52_RS21455	COG4483	Protein conserved in bacteria
WR52_RS21460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WR52_RS21465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WR52_RS21470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WR52_RS21475	COG2801	Transposase and inactivated derivatives
WR52_RS21485	COG0704	Plays a role in the regulation of phosphate uptake
WR52_RS21495	COG0573	inorganic phosphate transmembrane transporter activity
WR52_RS21500	COG0573	inorganic phosphate transmembrane transporter activity
WR52_RS21505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WR52_RS21510	COG0768	penicillin binding
WR52_RS21515	COG0477	Major facilitator Superfamily
WR52_RS21520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WR52_RS21530	COG5521	maltodextrose utilization protein MalA
WR52_RS21545	COG0735	belongs to the Fur family
WR52_RS21550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WR52_RS21555	COG1121	(ABC) transporter
WR52_RS21560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_RS21590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WR52_RS21595	COG2384	SAM-dependent methyltransferase
WR52_RS21605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WR52_RS21610	COG0358	DNA primase activity
WR52_RS21620	COG0517	IMP dehydrogenase activity
WR52_RS21635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WR52_RS21640	COG0295	cytidine deaminase activity
WR52_RS21645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WR52_RS21655	COG1480	7TM receptor with intracellular HD hydrolase
WR52_RS21660	COG1702	phosphate starvation-inducible protein PhoH
WR52_RS21680	COG1610	YqeY-like protein
WR52_RS21685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WR52_RS21690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WR52_RS21695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WR52_RS21725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WR52_RS21730	COG1733	regulation of RNA biosynthetic process
WR52_RS21755	COG1466	dna polymerase III delta subunit
WR52_RS21765	COG0658	competence protein
WR52_RS21765	COG2333	competence protein COMEC
WR52_RS21770	COG2131	deaminase
WR52_RS21775	COG1596	polysaccharide export
WR52_RS21775	COG1555	photosystem II stabilization
WR52_RS21780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WR52_RS21785	COG2226	methyltransferase
WR52_RS21790	COG0799	negative regulation of ribosome biogenesis
WR52_RS21795	COG1713	HD superfamily hydrolase involved in NAD metabolism
WR52_RS21805	COG1534	Rna-binding protein
WR52_RS21815	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WR52_RS21820	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
WR52_RS21855	COG0778	Nitroreductase
WR52_RS21860	COG2357	RelA SpoT domain protein
WR52_RS21870	COG1785	Belongs to the alkaline phosphatase family
WR52_RS21880	COG2267	carboxylic ester hydrolase activity
WR52_RS21920	COG2801	Transposase and inactivated derivatives
WR52_RS21935	COG3186	Phenylalanine-4-hydroxylase
WR52_RS21945	COG2514	catechol 2,3-dioxygenase activity
WR52_RS21950	COG2259	Doxx family
WR52_RS21990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_RS22000	COG1012	belongs to the aldehyde dehydrogenase family
WR52_RS22000	COG1454	alcohol dehydrogenase
WR52_RS22005	COG0626	cystathionine gamma-synthase activity
WR52_RS22010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WR52_RS22035	COG0768	penicillin binding
WR52_RS22055	COG0826	peptidase U32
WR52_RS22060	COG0826	peptidase U32
WR52_RS22065	COG4122	O-methyltransferase activity
WR52_RS22070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WR52_RS22100	COG0628	permease
WR52_RS22120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WR52_RS22135	COG1104	cysteine desulfurase activity
WR52_RS22140	COG1959	2 iron, 2 sulfur cluster binding
WR52_RS22145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WR52_RS22160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WR52_RS22185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WR52_RS22195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WR52_RS22195	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
WR52_RS22200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
WR52_RS22205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WR52_RS22205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WR52_RS22215	COG2244	polysaccharide biosynthetic process
WR52_RS22220	COG2323	membrane
WR52_RS22230	COG1862	Preprotein translocase
WR52_RS22260	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
WR52_RS22290	COG0157	Belongs to the NadC ModD family
WR52_RS22295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WR52_RS22300	COG1104	cysteine desulfurase activity
WR52_RS22305	COG1827	regulation of RNA biosynthetic process
WR52_RS22310	COG2258	MOSC domain
WR52_RS22315	COG0077	Prephenate dehydratase
WR52_RS22320	COG0577	efflux transmembrane transporter activity
WR52_RS22325	COG0577	efflux transmembrane transporter activity
WR52_RS22330	COG1136	(ABC) transporter
WR52_RS22335	COG5002	protein histidine kinase activity
WR52_RS22340	COG0745	RESPONSE REGULATOR receiver
WR52_RS22350	COG3290	protein histidine kinase activity
WR52_RS22360	COG2868	ribosomal protein
WR52_RS22370	COG1530	ribonuclease E activity
WR52_RS22375	COG1994	Peptidase M50
WR52_RS22380	COG0739	heme binding
WR52_RS22385	COG2894	cell division
WR52_RS22405	COG1077	Cell shape determining protein MreB Mrl
WR52_RS22425	COG0285	dihydrofolate synthase activity
WR52_RS22440	COG1388	LysM domain
WR52_RS22450	COG0113	porphobilinogen synthase activity
WR52_RS22455	COG1587	Uroporphyrinogen-III synthase
WR52_RS22465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WR52_RS22475	COG1846	Transcriptional regulator
WR52_RS22480	COG1764	response to oxidative stress
WR52_RS22495	COG1067	ATP-dependent peptidase activity
WR52_RS22495	COG0470	DNA polymerase III
WR52_RS22535	COG0622	Phosphoesterase
WR52_RS22550	COG5401	PFAM Sporulation and spore germination
WR52_RS22570	COG1309	transcriptional regulator
WR52_RS22580	COG2197	response regulator
WR52_RS22585	COG2233	PERMEase
WR52_RS22590	COG0402	S-adenosylhomocysteine deaminase activity
WR52_RS22595	COG1983	PspC domain protein
WR52_RS22600	COG1396	sequence-specific DNA binding
WR52_RS22605	COG0697	spore germination
WR52_RS22615	COG1959	2 iron, 2 sulfur cluster binding
WR52_RS22620	COG1668	transmembrane transport
WR52_RS22625	COG4152	abc transporter atp-binding protein
WR52_RS22630	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
WR52_RS22635	COG1360	Flagellar Motor Protein
WR52_RS22640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WR52_RS22645	COG1876	peptidase activity
WR52_RS22650	COG0824	Thioesterase
WR52_RS22655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WR52_RS22660	COG1053	succinate dehydrogenase
WR52_RS22665	COG2009	succinate dehydrogenase
WR52_RS22670	COG1719	4-vinyl reductase, 4VR
WR52_RS22680	COG3118	belongs to the thioredoxin family
WR52_RS22685	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
WR52_RS22690	COG2086	electron transfer activity
WR52_RS22695	COG1024	Enoyl-CoA hydratase
WR52_RS22700	COG1309	transcriptional regulator
WR52_RS22705	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_RS22735	COG2318	DinB family
WR52_RS22760	COG1131	(ABC) transporter
WR52_RS22765	COG2205	protein histidine kinase activity
WR52_RS22770	COG0745	RESPONSE REGULATOR receiver
WR52_RS22780	COG4895	conserved protein (DUF2196)
WR52_RS22785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WR52_RS22795	COG4509	Sortase family
WR52_RS22800	COG1120	ATPase activity
WR52_RS22815	COG5386	Cell surface protein
WR52_RS22825	COG5386	Cell surface protein
WR52_RS22830	COG1114	Component of the transport system for branched-chain amino acids
WR52_RS22835	COG1187	pseudouridine synthase activity
WR52_RS22845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WR52_RS22845	COG1796	DNA polymerase
WR52_RS22850	COG1286	toxin biosynthetic process
WR52_RS22895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WR52_RS22905	COG1418	mRNA catabolic process
WR52_RS22920	COG2814	Major facilitator Superfamily
WR52_RS22925	COG1566	PFAM secretion protein HlyD family protein
WR52_RS22930	COG1309	transcriptional regulator
WR52_RS22935	COG1363	Peptidase, m42
WR52_RS22960	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WR52_RS22975	COG1484	DNA-dependent DNA replication
WR52_RS22980	COG3611	Membrane attachment protein
WR52_RS22990	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
WR52_RS22995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WR52_RS23000	COG0237	dephospho-CoA kinase activity
WR52_RS23005	COG1971	Probably functions as a manganese efflux pump
WR52_RS23015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WR52_RS23015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WR52_RS23020	COG5002	protein histidine kinase activity
WR52_RS23025	COG0745	RESPONSE REGULATOR receiver
WR52_RS23040	COG0538	isocitrate dehydrogenase activity
WR52_RS23045	COG0372	Belongs to the citrate synthase family
WR52_RS23055	COG0628	permease
WR52_RS23060	COG3030	protein affecting phage T7 exclusion by the F plasmid
WR52_RS23085	COG1725	Transcriptional regulator
WR52_RS23090	COG0281	malic enzyme
WR52_RS23095	COG0587	DNA-directed DNA polymerase activity
WR52_RS23110	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WR52_RS23125	COG4109	DRTGG domain
WR52_RS23140	COG0006	proline dipeptidase activity
WR52_RS23170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_RS23175	COG0662	Cupin 2, conserved barrel domain protein
WR52_RS23190	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_RS23195	COG0589	response to stress
WR52_RS23235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_RS23260	COG0827	DNA restriction-modification system
WR52_RS23265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
WR52_RS23270	COG3874	Sporulation protein YtfJ
WR52_RS23285	COG1574	metal-dependent hydrolase with the TIM-barrel fold
WR52_RS23295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WR52_RS23310	COG1104	cysteine desulfurase activity
WR52_RS23320	COG0583	DNA-binding transcription factor activity
WR52_RS23325	COG0697	spore germination
WR52_RS23330	COG1309	transcriptional regulator
WR52_RS23335	COG1956	GAF domain-containing protein
WR52_RS23340	COG0626	cystathionine gamma-synthase activity
WR52_RS23375	COG0110	maltose O-acetyltransferase activity
WR52_RS23380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WR52_RS23385	COG0454	-acetyltransferase
WR52_RS23390	COG0517	IMP dehydrogenase activity
WR52_RS23395	COG0123	including yeast histone deacetylase and acetoin utilization protein
WR52_RS23410	COG0745	RESPONSE REGULATOR receiver
WR52_RS23420	COG0666	response to abiotic stimulus
WR52_RS23450	COG1609	Transcriptional regulator
WR52_RS23455	COG1605	Chorismate mutase
WR52_RS23455	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
WR52_RS23460	COG4851	CamS sex pheromone cAM373 precursor
WR52_RS23465	COG3118	belongs to the thioredoxin family
WR52_RS23475	COG2309	aminopeptidase activity
WR52_RS23495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_RS23500	COG0697	spore germination
WR52_RS23505	COG0789	Transcriptional regulator
WR52_RS23520	COG1674	ftsk spoiiie
WR52_RS23525	COG0860	N-Acetylmuramoyl-L-alanine amidase
WR52_RS23525	COG1388	LysM domain
WR52_RS23535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WR52_RS23545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WR52_RS23550	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
WR52_RS23555	COG1363	Peptidase, m42
WR52_RS23565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_RS23580	COG0510	thiamine kinase activity
WR52_RS23585	COG1523	belongs to the glycosyl hydrolase 13 family
WR52_RS23595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WR52_RS23600	COG1349	DNA-binding transcription factor activity
WR52_RS23605	COG1187	pseudouridine synthase activity
WR52_RS23610	COG2244	polysaccharide biosynthetic process
WR52_RS23615	COG2081	HI0933 family
WR52_RS23620	COG2814	Major facilitator Superfamily
WR52_RS23630	COG3832	glyoxalase III activity
WR52_RS23650	COG1329	Transcriptional regulator
WR52_RS23675	COG0314	molybdopterin synthase activity
WR52_RS23680	COG1763	Mo-molybdopterin cofactor biosynthetic process
WR52_RS23685	COG0303	'Molybdopterin
WR52_RS23695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WR52_RS23700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WR52_RS23720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WR52_RS23730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WR52_RS23770	COG2814	Major facilitator Superfamily
WR52_RS23775	COG0475	glutathione-regulated potassium exporter activity
WR52_RS23780	COG0490	domain, Protein
WR52_RS23785	COG0582	viral genome integration into host DNA
WR52_RS23795	COG1136	(ABC) transporter
WR52_RS23815	COG1242	4 iron, 4 sulfur cluster binding
WR52_RS23820	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
WR52_RS23825	COG1794	racemase activity, acting on amino acids and derivatives
WR52_RS23845	COG2267	carboxylic ester hydrolase activity
WR52_RS23850	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WR52_RS23855	COG0671	phosphoesterase, PA-phosphatase related
WR52_RS23860	COG0438	transferase activity, transferring glycosyl groups
WR52_RS23945	COG5002	protein histidine kinase activity
WR52_RS23950	COG3852	Histidine kinase
WR52_RS23960	COG2267	carboxylic ester hydrolase activity
WR52_RS23965	COG1368	sulfuric ester hydrolase activity
WR52_RS23985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WR52_RS23990	COG1116	anion transmembrane transporter activity
WR52_RS23995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WR52_RS24020	COG0494	nUDIX hydrolase
WR52_RS24055	COG1854	S-ribosylhomocysteine lyase activity
WR52_RS24065	COG0288	reversible hydration of carbon dioxide
WR52_RS24075	COG1271	oxidase subunit
WR52_RS24080	COG1294	oxidase, subunit
WR52_RS24095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_RS24115	COG1842	Phage shock protein A
WR52_RS24145	COG5002	protein histidine kinase activity
WR52_RS24150	COG0745	RESPONSE REGULATOR receiver
WR52_RS24175	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
WR52_RS24180	COG1597	lipid kinase activity
WR52_RS24215	COG0586	Pfam SNARE associated Golgi protein
WR52_RS24225	COG0577	efflux transmembrane transporter activity
WR52_RS24230	COG1136	(ABC) transporter
WR52_RS24235	COG3708	Transcriptional regulator
WR52_RS24235	COG2207	Transcriptional regulator
WR52_RS24245	COG5658	integral membrane protein
WR52_RS24250	COG0640	Transcriptional regulator
WR52_RS24255	COG0745	RESPONSE REGULATOR receiver
WR52_RS24260	COG2205	protein histidine kinase activity
WR52_RS24265	COG0577	efflux transmembrane transporter activity
WR52_RS24270	COG0577	efflux transmembrane transporter activity
WR52_RS24275	COG1136	(ABC) transporter
WR52_RS24280	COG0577	efflux transmembrane transporter activity
WR52_RS24295	COG2188	Transcriptional regulator
WR52_RS24315	COG3964	amidohydrolase
WR52_RS24335	COG4948	Mandelate Racemase Muconate Lactonizing
WR52_RS24345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WR52_RS24360	COG1169	isochorismate synthase
WR52_RS24365	COG1575	Belongs to the MenA family. Type 1 subfamily
WR52_RS24370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WR52_RS24395	COG0058	SHG alpha-glucan phosphorylase activity
WR52_RS24405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WR52_RS24515	COG0544	peptidyl-prolyl cis-trans isomerase activity
WR52_RS24555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WR52_RS24580	COG2155	Conserved Protein
WR52_RS24585	COG1098	S1 RNA binding domain
WR52_RS24590	COG0436	Aminotransferase
WR52_RS24595	COG1522	sequence-specific DNA binding
WR52_RS24600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WR52_RS24605	COG2267	carboxylic ester hydrolase activity
WR52_RS24615	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WR52_RS24635	COG5018	Exonuclease
WR52_RS24640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WR52_RS24660	COG2050	protein possibly involved in aromatic compounds catabolism
WR52_RS24670	COG1268	BioY protein
WR52_RS24675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WR52_RS24680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WR52_RS24695	COG3584	3D domain protein
WR52_RS24710	COG1252	NADH dehydrogenase
WR52_RS24725	COG3708	Transcriptional regulator
WR52_RS24740	COG1683	Conserved Protein
WR52_RS24755	COG0316	Belongs to the HesB IscA family
WR52_RS24770	COG1252	NADH dehydrogenase
WR52_RS24780	COG2274	protein secretion by the type I secretion system
WR52_RS24785	COG0390	transport system, permease component
WR52_RS24790	COG2824	Alkylphosphonate utilization operon protein PhnA
WR52_RS24825	COG4837	Protein of unknown function (DUF1462)
WR52_RS24830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WR52_RS24840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WR52_RS24845	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WR52_RS24855	COG2249	NAD(P)H dehydrogenase (quinone) activity
WR52_RS24865	COG0647	UMP catabolic process
WR52_RS24875	COG2445	Protein of unknown function DUF86
WR52_RS24880	COG1494	fructose-1,6-bisphosphatase
WR52_RS24900	COG4470	Protein conserved in bacteria
WR52_RS24910	COG0789	Transcriptional regulator
WR52_RS24915	COG4377	Putative membrane peptidase family (DUF2324)
WR52_RS24940	COG0739	heme binding
WR52_RS24950	COG3377	Domain of unknown function (DUF1805)
WR52_RS24955	COG0737	Belongs to the 5'-nucleotidase family
WR52_RS24960	COG0719	Fe-S assembly protein
WR52_RS24965	COG0822	iron-sulfur transferase activity
WR52_RS24970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WR52_RS24975	COG0719	Fe-S assembly protein
WR52_RS24980	COG0396	ATPase activity
WR52_RS24985	COG1464	Belongs to the NlpA lipoprotein family
WR52_RS24990	COG1464	Belongs to the NlpA lipoprotein family
WR52_RS24995	COG2011	ABC-type metal ion transport system permease component
WR52_RS25010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WR52_RS25015	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
WR52_RS25025	COG1393	Belongs to the ArsC family
WR52_RS25045	COG0039	L-malate dehydrogenase activity
WR52_RS25065	COG1309	transcriptional regulator
WR52_RS25070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_RS25075	COG1960	acyl-CoA dehydrogenase activity
WR52_RS25085	COG0183	Belongs to the thiolase family
WR52_RS25090	COG1250	3-hydroxyacyl-CoA dehydrogenase
WR52_RS25090	COG1024	Enoyl-CoA hydratase
WR52_RS25100	COG1686	Belongs to the peptidase S11 family
WR52_RS25115	COG0011	TIGRFAM Protein of
WR52_RS25120	COG0840	transmembrane signaling receptor activity
WR52_RS25135	COG2814	Major facilitator Superfamily
WR52_RS25140	COG0531	amino acid
WR52_RS25165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_RS25195	COG0586	Pfam SNARE associated Golgi protein
WR52_RS25205	COG1376	ErfK ybiS ycfS ynhG family protein
WR52_RS25210	COG0745	RESPONSE REGULATOR receiver
WR52_RS25215	COG5002	protein histidine kinase activity
WR52_RS25245	COG0840	transmembrane signaling receptor activity
WR52_RS25250	COG2151	metal-sulfur cluster biosynthetic enzyme
WR52_RS25255	COG3227	Zinc metalloprotease (Elastase)
WR52_RS25260	COG1741	Belongs to the pirin family
WR52_RS25275	COG0586	Pfam SNARE associated Golgi protein
WR52_RS25280	COG0475	glutathione-regulated potassium exporter activity
WR52_RS25285	COG0490	domain, Protein
WR52_RS25290	COG1115	amino acid carrier protein
WR52_RS25300	COG0783	Belongs to the Dps family
WR52_RS25315	COG1611	Belongs to the LOG family
WR52_RS25325	COG1528	Iron-storage protein
WR52_RS25335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_RS25340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_RS25345	COG1115	amino acid carrier protein
WR52_RS25350	COG1115	amino acid carrier protein
WR52_RS25355	COG2910	NAD(P)H-binding
WR52_RS25370	COG0656	L-ascorbic acid biosynthetic process
WR52_RS25375	COG2814	Major facilitator Superfamily
WR52_RS25380	COG1733	regulation of RNA biosynthetic process
WR52_RS25390	COG1252	NADH dehydrogenase
WR52_RS25445	COG0488	(ABC) transporter
WR52_RS25450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_RS25525	COG0557	exoribonuclease II activity
WR52_RS25530	COG1647	Serine aminopeptidase, S33
WR52_RS25535	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WR52_RS25540	COG1346	cytolysis
WR52_RS25575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WR52_RS25590	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WR52_RS25615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WR52_RS25630	COG2323	membrane
WR52_RS25640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WR52_RS25650	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WR52_RS25660	COG1051	belongs to the nudix hydrolase family
WR52_RS25670	COG0492	ferredoxin-NADP+ reductase activity
WR52_RS25675	COG0457	Tetratricopeptide repeat
WR52_RS25680	COG0110	maltose O-acetyltransferase activity
WR52_RS25700	COG1950	PFAM Membrane protein of
WR52_RS25710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WR52_RS25715	COG0556	nucleotide-excision repair
WR52_RS25735	COG0789	Transcriptional regulator
WR52_RS25755	COG0583	DNA-binding transcription factor activity
WR52_RS25765	COG0655	NAD(P)H dehydrogenase (quinone) activity
WR52_RS25770	COG0488	(ABC) transporter
WR52_RS25780	COG1132	(ABC) transporter
WR52_RS25785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WR52_RS25790	COG3409	Peptidoglycan-binding domain 1 protein
WR52_RS25790	COG0793	Belongs to the peptidase S41A family
WR52_RS25795	COG2177	Part of the ABC transporter FtsEX involved in
WR52_RS25800	COG2884	Cell division ATP-binding protein ftsE
WR52_RS25810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WR52_RS25825	COG1131	(ABC) transporter
WR52_RS25855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WR52_RS25860	COG1278	Cold shock
WR52_RS25865	COG1040	competence protein
WR52_RS25870	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
WR52_RS25875	COG1388	LysM domain
WR52_RS25875	COG0791	NLP P60 protein
WR52_RS25880	COG1733	regulation of RNA biosynthetic process
WR52_RS25885	COG1307	EDD domain protein, DegV family
WR52_RS25890	COG1739	Uncharacterized protein family UPF0029
WR52_RS25895	COG1316	TRANSCRIPTIONal
WR52_RS25900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WR52_RS25905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WR52_RS25910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WR52_RS25920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WR52_RS25920	COG3933	PFAM sigma-54 factor interaction domain-containing protein
WR52_RS25940	COG1486	melibiose metabolic process
WR52_RS25945	COG1447	Phosphotransferase system cellobiose-specific component IIA
WR52_RS25950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WR52_RS25960	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WR52_RS25970	COG1447	Phosphotransferase system cellobiose-specific component IIA
WR52_RS25980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WR52_RS25985	COG1301	dicarboxylic acid transport
WR52_RS26000	COG1511	domain protein
WR52_RS26005	COG0583	DNA-binding transcription factor activity
WR52_RS26010	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
WR52_RS26020	COG1271	oxidase subunit
WR52_RS26025	COG1294	oxidase, subunit
WR52_RS26030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WR52_RS26040	COG1620	l-lactate permease
WR52_RS26050	COG2389	metal-binding protein
WR52_RS26060	COG1368	sulfuric ester hydrolase activity
WR52_RS26070	COG0791	NLP P60 protein
WR52_RS26070	COG1388	LysM domain
WR52_RS26075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_RS26085	COG1215	transferase activity, transferring glycosyl groups
WR52_RS26095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WR52_RS26100	COG3584	3D domain protein
WR52_RS26100	COG1388	LysM domain
WR52_RS26125	COG4715	Zinc finger, swim domain protein
WR52_RS26130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WR52_RS26170	COG0577	efflux transmembrane transporter activity
WR52_RS26175	COG1136	(ABC) transporter
WR52_RS26200	COG5002	protein histidine kinase activity
WR52_RS26205	COG0745	RESPONSE REGULATOR receiver
WR52_RS26210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WR52_RS26215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WR52_RS26235	COG0438	transferase activity, transferring glycosyl groups
WR52_RS26255	COG0438	transferase activity, transferring glycosyl groups
WR52_RS26270	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WR52_RS26275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WR52_RS26280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WR52_RS26285	COG4464	protein tyrosine phosphatase activity
WR52_RS26290	COG0489	protein tyrosine kinase activity
WR52_RS26295	COG3944	biosynthesis protein
WR52_RS26300	COG0489	protein tyrosine kinase activity
WR52_RS26315	COG1609	Transcriptional regulator
WR52_RS26325	COG0739	heme binding
WR52_RS26340	COG3279	Response regulator of the LytR AlgR family
WR52_RS26345	COG2385	sporulation resulting in formation of a cellular spore
WR52_RS26360	COG4836	Membrane
WR52_RS26365	COG1007	ATP synthesis coupled electron transport
WR52_RS26370	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WR52_RS26375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WR52_RS26385	COG0839	Belongs to the complex I subunit 6 family
WR52_RS26405	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WR52_RS26420	COG5001	Diguanylate cyclase
WR52_RS26420	COG3300	MHYT domain
WR52_RS26470	COG0356	it plays a direct role in the translocation of protons across the membrane
WR52_RS26505	COG0698	ribose 5-phosphate isomerase
WR52_RS26520	COG2259	Doxx family
WR52_RS26525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WR52_RS26540	COG0009	L-threonylcarbamoyladenylate synthase
WR52_RS26575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WR52_RS26580	COG1494	fructose-1,6-bisphosphatase
WR52_RS26600	COG4821	SIS domain
WR52_RS26610	COG3343	RNA polymerase activity
WR52_RS26620	COG1960	acyl-CoA dehydrogenase activity
WR52_RS26625	COG1960	acyl-CoA dehydrogenase activity
WR52_RS26630	COG1250	3-hydroxyacyl-CoA dehydrogenase
WR52_RS26635	COG0183	Belongs to the thiolase family
WR52_RS26640	COG2181	nitrate reductase activity
WR52_RS26640	COG0247	lactate metabolic process
WR52_RS26645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WR52_RS26655	COG3300	MHYT domain
WR52_RS26655	COG5001	Diguanylate cyclase
WR52_RS26670	COG3227	Zinc metalloprotease (Elastase)
WR52_RS26675	COG2197	response regulator
WR52_RS26680	COG4585	Histidine kinase
WR52_RS26685	COG0842	Transport permease protein
WR52_RS26690	COG1131	(ABC) transporter
WR52_RS26695	COG0024	Methionine aminopeptidase
WR52_RS26705	COG2234	aminopeptidase activity
WR52_RS26735	COG4506	Protein conserved in bacteria
WR52_RS26740	COG1619	proteins homologs of microcin C7 resistance protein MccF
WR52_RS26765	COG2814	Major facilitator Superfamily
WR52_RS26770	COG0789	Transcriptional regulator
WR52_RS26775	COG0584	glycerophosphoryl diester phosphodiesterase
WR52_RS26780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WR52_RS26790	COG1994	Peptidase M50
WR52_RS26800	COG1078	dGTPase activity
WR52_RS26805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_RS26810	COG1120	ATPase activity
WR52_RS26815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_RS26820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_RS26840	COG0280	phosphate acetyltransferase
WR52_RS26855	COG3773	Cell wall hydrolase
WR52_RS26865	COG2363	Small membrane protein
WR52_RS26875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WR52_RS26880	COG2233	PERMEase
WR52_RS26885	COG0561	phosphatase activity
WR52_RS26890	COG2814	Major facilitator Superfamily
WR52_RS26900	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
WR52_RS26905	COG1131	(ABC) transporter
WR52_RS26910	COG2755	lipolytic protein G-D-S-L family
WR52_RS26915	COG1609	Transcriptional regulator
WR52_RS26925	COG0460	homoserine dehydrogenase
WR52_RS26935	COG2873	o-acetylhomoserine
WR52_RS26945	COG1011	Hydrolase
WR52_RS26950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WR52_RS26960	COG2197	response regulator
WR52_RS26965	COG2203	Gaf domain
WR52_RS26965	COG4585	Histidine kinase
WR52_RS26970	COG0351	phosphomethylpyrimidine kinase
WR52_RS26975	COG3706	GGDEF domain
WR52_RS26980	COG2879	small protein
WR52_RS26985	COG1966	Carbon starvation protein
WR52_RS26990	COG3279	Response regulator of the LytR AlgR family
WR52_RS26995	COG0477	Major facilitator Superfamily
WR52_RS27005	COG0438	transferase activity, transferring glycosyl groups
WR52_RS27020	COG0840	transmembrane signaling receptor activity
WR52_RS27030	COG1607	acyl-coa hydrolase
WR52_RS27035	COG1216	Glycosyl transferase, family 2
WR52_RS27045	COG1216	Glycosyl transferase, family 2
WR52_RS27060	COG0488	(ABC) transporter
WR52_RS27065	COG1696	Membrane protein involved in D-alanine export
WR52_RS27075	COG1309	transcriptional regulator
WR52_RS27080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WR52_RS27085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WR52_RS27085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WR52_RS27090	COG0628	permease
WR52_RS27110	COG3275	phosphorelay sensor kinase activity
WR52_RS27115	COG2814	Major facilitator Superfamily
WR52_RS27120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WR52_RS27125	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
WR52_RS27145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WR52_RS27150	COG1272	protein, Hemolysin III
WR52_RS27170	COG1164	Oligoendopeptidase f
WR52_RS27190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WR52_RS27195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
WR52_RS27200	COG4853	Protein conserved in bacteria
WR52_RS27210	COG5002	protein histidine kinase activity
WR52_RS27215	COG0745	RESPONSE REGULATOR receiver
WR52_RS27245	COG0305	Participates in initiation and elongation during chromosome replication
WR52_RS27255	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
WR52_RS27260	COG4241	membrane
WR52_RS27280	COG0012	GTP binding
WR52_RS27285	COG4481	Protein conserved in bacteria
WR52_RS27290	COG0668	transmembrane transport
WR52_RS27300	COG1475	DNA binding
WR52_RS27305	COG1192	Involved in chromosome partitioning
WR52_RS27330	COG1847	R3H domain protein
WR52_RS27345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WR52_RS27840	COG0489	protein tyrosine kinase activity
WR52_RS28220	COG0488	(ABC) transporter
WR52_RS28280	COG2252	PERMEase
WR52_RS28380	COG1215	transferase activity, transferring glycosyl groups
WR52_RS28655	COG1597	lipid kinase activity
WR52_RS28680	COG1012	belongs to the aldehyde dehydrogenase family
WR52_RS28755	COG1473	amidohydrolase
WR52_RS29335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WR52_RS29390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WR52_RS29430	COG2208	phosphoserine phosphatase activity
WR52_RS29495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WR52_RS29765	COG0201	protein transport