locus-tag	class	description
L6497_RS00010	COG0592	DNA-directed DNA polymerase activity
L6497_RS00015	COG2501	S4 domain
L6497_RS00025	COG0187	DNA topoisomerase II activity
L6497_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6497_RS00065	COG0516	GMP reductase activity
L6497_RS00065	COG0517	IMP dehydrogenase activity
L6497_RS00070	COG1686	Belongs to the peptidase S11 family
L6497_RS00100	COG1428	Deoxynucleoside kinase
L6497_RS00105	COG1428	Deoxynucleoside kinase
L6497_RS00110	COG1335	isochorismatase
L6497_RS00115	COG0590	tRNA wobble adenosine to inosine editing
L6497_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L6497_RS00180	COG1982	Orn Lys Arg decarboxylase major
L6497_RS00190	COG0470	DNA polymerase III
L6497_RS00195	COG1774	PSP1 C-terminal conserved region
L6497_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L6497_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L6497_RS00220	COG2002	toxin-antitoxin pair type II binding
L6497_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6497_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6497_RS00230	COG0084	hydrolase, TatD family'
L6497_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6497_RS00250	COG4466	Protein conserved in bacteria
L6497_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L6497_RS00270	COG0251	oxidation-reduction process
L6497_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L6497_RS00305	COG2002	toxin-antitoxin pair type II binding
L6497_RS00310	COG2244	polysaccharide biosynthetic process
L6497_RS00315	COG3956	TIGRFAM MazG family protein
L6497_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L6497_RS00340	COG1098	S1 RNA binding domain
L6497_RS00355	COG2208	phosphoserine phosphatase activity
L6497_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L6497_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L6497_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6497_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L6497_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
L6497_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6497_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L6497_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L6497_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L6497_RS00420	COG1396	sequence-specific DNA binding
L6497_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6497_RS00515	COG3880	PFAM UvrB UvrC protein
L6497_RS00525	COG0542	response to heat
L6497_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L6497_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
L6497_RS00560	COG1045	serine acetyltransferase
L6497_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6497_RS00580	COG3688	RNA-binding protein containing a PIN domain
L6497_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6497_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
L6497_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L6497_RS00625	COG2813	Specifically methylates the guanine in position
L6497_RS00640	COG1358	cellular component organization or biogenesis
L6497_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
L6497_RS00770	COG0201	protein transport
L6497_RS00780	COG0024	Methionine aminopeptidase
L6497_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L6497_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6497_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6497_RS00855	COG0489	protein tyrosine kinase activity
L6497_RS00865	COG2194	sulfuric ester hydrolase activity
L6497_RS00870	COG0726	polysaccharide deacetylase
L6497_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L6497_RS00955	COG4856	YbbR-like protein
L6497_RS01000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L6497_RS01040	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS01045	COG2011	ABC-type metal ion transport system permease component
L6497_RS01050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6497_RS01055	COG1464	Belongs to the NlpA lipoprotein family
L6497_RS01060	COG1063	alcohol dehydrogenase
L6497_RS01070	COG0277	FAD linked oxidase domain protein
L6497_RS01075	COG2271	Major facilitator Superfamily
L6497_RS01085	COG2814	Major facilitator Superfamily
L6497_RS01100	COG0601	transmembrane transport
L6497_RS01105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6497_RS01110	COG0444	Belongs to the ABC transporter superfamily
L6497_RS01115	COG4608	Belongs to the ABC transporter superfamily
L6497_RS01120	COG4166	transmembrane transport
L6497_RS01130	COG2207	Transcriptional regulator
L6497_RS01140	COG1309	transcriptional regulator
L6497_RS01150	COG4166	transmembrane transport
L6497_RS01155	COG4166	transmembrane transport
L6497_RS01160	COG0656	L-ascorbic acid biosynthetic process
L6497_RS01180	COG4149	molybdate abc transporter
L6497_RS01185	COG0725	ABC transporter, periplasmic molybdate-binding protein
L6497_RS01190	COG1910	domain protein
L6497_RS01205	COG0697	spore germination
L6497_RS01220	COG0204	Acyl-transferase
L6497_RS01230	COG1609	Transcriptional regulator
L6497_RS01240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6497_RS01250	COG0084	hydrolase, TatD family'
L6497_RS01260	COG5298	Protein conserved in bacteria
L6497_RS01285	COG0488	(ABC) transporter
L6497_RS01300	COG0747	negative chemotaxis
L6497_RS01305	COG0601	transmembrane transport
L6497_RS01310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6497_RS01315	COG0444	Belongs to the ABC transporter superfamily
L6497_RS01320	COG4608	Belongs to the ABC transporter superfamily
L6497_RS01325	COG0561	phosphatase activity
L6497_RS01355	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L6497_RS01360	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6497_RS01370	COG2814	Major facilitator Superfamily
L6497_RS01380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L6497_RS01390	COG4294	response to UV
L6497_RS01395	COG0705	Rhomboid family
L6497_RS01395	COG0457	Tetratricopeptide repeat
L6497_RS01405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L6497_RS01410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6497_RS01415	COG0864	Transcriptional regulator
L6497_RS01420	COG2337	Toxic component of a toxin-antitoxin (TA) module
L6497_RS01425	COG2183	response to ionizing radiation
L6497_RS01520	COG0802	atpase or kinase
L6497_RS01525	COG1214	PFAM Peptidase M22, glycoprotease
L6497_RS01530	COG0456	acetyltransferase
L6497_RS01540	COG0488	(ABC) transporter
L6497_RS01555	COG1266	CAAX protease self-immunity
L6497_RS01570	COG5444	nuclease activity
L6497_RS01585	COG2252	PERMEase
L6497_RS01595	COG5002	protein histidine kinase activity
L6497_RS01670	COG2205	protein histidine kinase activity
L6497_RS01675	COG0745	RESPONSE REGULATOR receiver
L6497_RS01695	COG0697	spore germination
L6497_RS01720	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L6497_RS01725	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L6497_RS01730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L6497_RS01740	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L6497_RS01755	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L6497_RS01765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L6497_RS01775	COG0151	Belongs to the GarS family
L6497_RS01800	COG0210	DNA helicase
L6497_RS01810	COG4851	CamS sex pheromone cAM373 precursor
L6497_RS01830	COG1335	isochorismatase
L6497_RS01835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6497_RS01840	COG2011	ABC-type metal ion transport system permease component
L6497_RS01845	COG1464	Belongs to the NlpA lipoprotein family
L6497_RS01860	COG0003	Pfam Anion-transporting ATPase
L6497_RS01865	COG1846	Transcriptional regulator
L6497_RS01870	COG4682	membrane
L6497_RS01890	COG1597	lipid kinase activity
L6497_RS01895	COG0546	phosphoglycolate phosphatase activity
L6497_RS01900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6497_RS01910	COG1012	belongs to the aldehyde dehydrogenase family
L6497_RS01915	COG2076	Multidrug Resistance protein
L6497_RS01920	COG2309	aminopeptidase activity
L6497_RS01935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6497_RS01940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6497_RS01945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6497_RS01955	COG4807	Protein conserved in bacteria
L6497_RS01980	COG1757	Na H antiporter
L6497_RS01985	COG1473	amidohydrolase
L6497_RS02000	COG0450	alkyl hydroperoxide reductase
L6497_RS02020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6497_RS02025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6497_RS02030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6497_RS02045	COG0166	Belongs to the GPI family
L6497_RS02075	COG5002	protein histidine kinase activity
L6497_RS02095	COG3541	Predicted nucleotidyltransferase
L6497_RS02100	COG2814	Major facilitator Superfamily
L6497_RS02105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6497_RS02105	COG0723	plastoquinol--plastocyanin reductase activity
L6497_RS02115	COG0765	amino acid transport
L6497_RS02120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6497_RS02130	COG0840	transmembrane signaling receptor activity
L6497_RS02140	COG0366	Alpha amylase catalytic
L6497_RS02145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6497_RS02145	COG1263	PTS System
L6497_RS02145	COG2190	(PTS) system
L6497_RS02195	COG0556	nucleotide-excision repair
L6497_RS02240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L6497_RS02255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6497_RS02265	COG1116	anion transmembrane transporter activity
L6497_RS02275	COG0488	(ABC) transporter
L6497_RS02325	COG2270	Major facilitator Superfamily
L6497_RS02355	COG2310	stress, protein
L6497_RS02360	COG2310	stress, protein
L6497_RS02365	COG2310	stress, protein
L6497_RS02370	COG0861	Integral membrane protein TerC family
L6497_RS02380	COG3853	Toxic anion resistance protein (TelA)
L6497_RS02395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L6497_RS02405	COG1295	ribonuclease BN
L6497_RS02410	COG2217	Heavy metal translocating P-type atpase
L6497_RS02415	COG0697	spore germination
L6497_RS02435	COG0586	Pfam SNARE associated Golgi protein
L6497_RS02450	COG3871	stress protein (general stress protein 26)
L6497_RS02455	COG0387	Pfam Sodium calcium exchanger
L6497_RS02465	COG0535	radical SAM domain protein
L6497_RS02485	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L6497_RS02505	COG3829	transcription factor binding
L6497_RS02515	COG0833	amino acid
L6497_RS02520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6497_RS02550	COG1263	PTS System
L6497_RS02550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6497_RS02555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6497_RS02570	COG0463	Glycosyl transferase, family 2
L6497_RS02580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L6497_RS02580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6497_RS02595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6497_RS02615	COG1228	amidohydrolase
L6497_RS02650	COG1988	membrane-bound metal-dependent
L6497_RS02655	COG1194	a g-specific adenine glycosylase
L6497_RS02680	COG1132	(ABC) transporter
L6497_RS02685	COG4129	membrane
L6497_RS02690	COG0069	glutamate synthase activity
L6497_RS02690	COG0070	glutamate synthase
L6497_RS02690	COG0067	glutamate synthase
L6497_RS02700	COG4555	ABC transporter
L6497_RS02720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L6497_RS02725	COG0735	belongs to the Fur family
L6497_RS02840	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L6497_RS02845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6497_RS02855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L6497_RS02865	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L6497_RS02870	COG5001	Diguanylate cyclase
L6497_RS02870	COG1716	ATPase activity
L6497_RS02875	COG2766	serine protein kinase
L6497_RS02895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6497_RS02905	COG1585	Membrane protein implicated in regulation of membrane protease activity
L6497_RS02910	COG2268	Band 7 protein
L6497_RS02920	COG3290	protein histidine kinase activity
L6497_RS02925	COG4565	transcriptional regulatory protein
L6497_RS02930	COG2851	Citrate transporter
L6497_RS02950	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6497_RS02955	COG3842	ATPase activity
L6497_RS02960	COG1175	transmembrane transport
L6497_RS02965	COG0395	ABC-type sugar transport system, permease component
L6497_RS02975	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L6497_RS02980	COG0745	RESPONSE REGULATOR receiver
L6497_RS02985	COG5002	protein histidine kinase activity
L6497_RS02995	COG4990	cell redox homeostasis
L6497_RS03005	COG3290	protein histidine kinase activity
L6497_RS03010	COG4565	transcriptional regulatory protein
L6497_RS03015	COG3493	citrate carrier protein
L6497_RS03020	COG0281	malic enzyme
L6497_RS03035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6497_RS03045	COG5002	protein histidine kinase activity
L6497_RS03050	COG0745	RESPONSE REGULATOR receiver
L6497_RS03055	COG0454	-acetyltransferase
L6497_RS03055	COG0456	acetyltransferase
L6497_RS03060	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6497_RS03065	COG3383	formate dehydrogenase (NAD+) activity
L6497_RS03070	COG2427	Protein of unknown function (DUF1641)
L6497_RS03085	COG0531	amino acid
L6497_RS03090	COG0640	Transcriptional regulator
L6497_RS03095	COG2217	Heavy metal translocating P-type atpase
L6497_RS03100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L6497_RS03115	COG3227	Zinc metalloprotease (Elastase)
L6497_RS03135	COG2720	vancomycin resistance protein
L6497_RS03140	COG1316	TRANSCRIPTIONal
L6497_RS03145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6497_RS03150	COG0346	lactoylglutathione lyase activity
L6497_RS03155	COG1253	flavin adenine dinucleotide binding
L6497_RS03160	COG1027	Aspartate ammonia-lyase
L6497_RS03165	COG1620	l-lactate permease
L6497_RS03180	COG3104	oligopeptide transport
L6497_RS03185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6497_RS03190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6497_RS03195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6497_RS03205	COG2226	methyltransferase
L6497_RS03210	COG0156	8-amino-7-oxononanoate synthase activity
L6497_RS03215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6497_RS03220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L6497_RS03230	COG4548	von Willebrand factor, type A
L6497_RS03235	COG0714	Associated with various cellular activities
L6497_RS03240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6497_RS03255	COG0531	amino acid
L6497_RS03260	COG2188	Transcriptional regulator
L6497_RS03265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6497_RS03265	COG1263	PTS System
L6497_RS03270	COG0366	Alpha amylase catalytic
L6497_RS03285	COG0697	spore germination
L6497_RS03290	COG4585	Histidine kinase
L6497_RS03295	COG2197	response regulator
L6497_RS03300	COG1404	Belongs to the peptidase S8 family
L6497_RS03315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6497_RS03320	COG1115	amino acid carrier protein
L6497_RS03325	COG1126	abc transporter atp-binding protein
L6497_RS03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6497_RS03335	COG0765	amino acid transport
L6497_RS03340	COG0765	amino acid transport
L6497_RS03345	COG0833	amino acid
L6497_RS03370	COG2378	regulation of single-species biofilm formation
L6497_RS03375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L6497_RS03380	COG5002	protein histidine kinase activity
L6497_RS03395	COG0659	secondary active sulfate transmembrane transporter activity
L6497_RS03410	COG0747	negative chemotaxis
L6497_RS03420	COG0601	transmembrane transport
L6497_RS03425	COG4608	Belongs to the ABC transporter superfamily
L6497_RS03435	COG2271	Major facilitator Superfamily
L6497_RS03440	COG1846	Transcriptional regulator
L6497_RS03445	COG0477	Major facilitator Superfamily
L6497_RS03450	COG1609	Transcriptional regulator
L6497_RS03455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6497_RS03470	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6497_RS03475	COG1879	ABC-type sugar transport system periplasmic component
L6497_RS03495	COG1063	alcohol dehydrogenase
L6497_RS03540	COG0840	transmembrane signaling receptor activity
L6497_RS03545	COG1388	LysM domain
L6497_RS03545	COG3584	3D domain protein
L6497_RS03550	COG1476	TRANSCRIPTIONal
L6497_RS03565	COG3104	oligopeptide transport
L6497_RS03570	COG1114	Component of the transport system for branched-chain amino acids
L6497_RS03585	COG1113	amino acid transport
L6497_RS03590	COG2252	PERMEase
L6497_RS03605	COG2153	protein acetylation
L6497_RS03615	COG0569	domain protein
L6497_RS03615	COG0475	glutathione-regulated potassium exporter activity
L6497_RS03630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L6497_RS03635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L6497_RS03640	COG4990	cell redox homeostasis
L6497_RS03655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6497_RS03660	COG0697	spore germination
L6497_RS03665	COG0531	amino acid
L6497_RS03675	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6497_RS03680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6497_RS03685	COG1918	ferrous iron import across plasma membrane
L6497_RS03685	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6497_RS03690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6497_RS03695	COG0573	inorganic phosphate transmembrane transporter activity
L6497_RS03700	COG0581	inorganic phosphate transmembrane transporter activity
L6497_RS03710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6497_RS03830	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
L6497_RS03850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6497_RS03855	COG1116	anion transmembrane transporter activity
L6497_RS03860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6497_RS03865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6497_RS03870	COG0352	thiamine-phosphate diphosphorylase activity
L6497_RS03875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6497_RS03880	COG2104	thiamine diphosphate biosynthetic process
L6497_RS03890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6497_RS03895	COG0351	phosphomethylpyrimidine kinase
L6497_RS03935	COG2205	protein histidine kinase activity
L6497_RS03940	COG2814	Major facilitator Superfamily
L6497_RS03945	COG1846	Transcriptional regulator
L6497_RS03970	COG0577	efflux transmembrane transporter activity
L6497_RS03970	COG1136	(ABC) transporter
L6497_RS03980	COG2252	PERMEase
L6497_RS03985	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS04000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6497_RS04005	COG1621	beta-fructofuranosidase activity
L6497_RS04010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6497_RS04010	COG1263	PTS System
L6497_RS04015	COG1609	Transcriptional regulator
L6497_RS04025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6497_RS04065	COG0778	Nitroreductase
L6497_RS04070	COG2719	SpoVR family
L6497_RS04075	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6497_RS04080	COG1937	Protein conserved in bacteria
L6497_RS04085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6497_RS04085	COG0425	Belongs to the sulfur carrier protein TusA family
L6497_RS04090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6497_RS04090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6497_RS04095	COG0425	Belongs to the sulfur carrier protein TusA family
L6497_RS04100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6497_RS04110	COG2210	Belongs to the sulfur carrier protein TusA family
L6497_RS04115	COG0730	response to heat
L6497_RS04125	COG1316	TRANSCRIPTIONal
L6497_RS04130	COG0604	alcohol dehydrogenase
L6497_RS04135	COG1283	sodium-dependent phosphate transmembrane transporter activity
L6497_RS04155	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6497_RS04160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6497_RS04180	COG3584	3D domain protein
L6497_RS04180	COG1388	LysM domain
L6497_RS04185	COG0577	efflux transmembrane transporter activity
L6497_RS04190	COG1136	(ABC) transporter
L6497_RS04200	COG5522	Integral membrane protein (intg_mem_TP0381)
L6497_RS04215	COG0577	efflux transmembrane transporter activity
L6497_RS04220	COG1114	Component of the transport system for branched-chain amino acids
L6497_RS04225	COG3546	catalase activity
L6497_RS04260	COG0586	Pfam SNARE associated Golgi protein
L6497_RS04295	COG0531	amino acid
L6497_RS04300	COG0475	glutathione-regulated potassium exporter activity
L6497_RS04310	COG1737	Transcriptional regulator
L6497_RS04320	COG1263	PTS System
L6497_RS04320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6497_RS04335	COG2259	Doxx family
L6497_RS04355	COG1522	sequence-specific DNA binding
L6497_RS04370	COG2076	Multidrug Resistance protein
L6497_RS04375	COG1309	transcriptional regulator
L6497_RS04380	COG2814	Major facilitator Superfamily
L6497_RS04385	COG4533	DNA binding
L6497_RS04390	COG2211	Major facilitator Superfamily
L6497_RS04400	COG0693	protein deglycase activity
L6497_RS04405	COG0753	catalase activity
L6497_RS04405	COG0693	protein deglycase activity
L6497_RS04415	COG0531	amino acid
L6497_RS04420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L6497_RS04430	COG1012	belongs to the aldehyde dehydrogenase family
L6497_RS04435	COG1132	(ABC) transporter
L6497_RS04440	COG1132	(ABC) transporter
L6497_RS04445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6497_RS04450	COG0765	amino acid transport
L6497_RS04455	COG1126	abc transporter atp-binding protein
L6497_RS04470	COG0189	ligase activity
L6497_RS04500	COG0028	Belongs to the TPP enzyme family
L6497_RS04505	COG3527	Alpha-acetolactate decarboxylase
L6497_RS04515	COG0561	phosphatase activity
L6497_RS04520	COG3409	Peptidoglycan-binding domain 1 protein
L6497_RS04520	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6497_RS04525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6497_RS04540	COG0659	secondary active sulfate transmembrane transporter activity
L6497_RS04565	COG0653	protein targeting
L6497_RS04570	COG2244	polysaccharide biosynthetic process
L6497_RS04580	COG4196	transglutaminase domain protein
L6497_RS04585	COG4196	transglutaminase domain protein
L6497_RS04605	COG1024	Enoyl-CoA hydratase
L6497_RS04625	COG1363	Peptidase, m42
L6497_RS04645	COG3938	Belongs to the proline racemase family
L6497_RS04660	COG0464	growth
L6497_RS04685	COG0601	transmembrane transport
L6497_RS04690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6497_RS04695	COG0444	Belongs to the ABC transporter superfamily
L6497_RS04700	COG4608	Belongs to the ABC transporter superfamily
L6497_RS04720	COG0477	Major facilitator Superfamily
L6497_RS04725	COG3290	protein histidine kinase activity
L6497_RS04730	COG4565	transcriptional regulatory protein
L6497_RS04735	COG3181	Tripartite tricarboxylate transporter family receptor
L6497_RS04755	COG3973	AAA domain
L6497_RS04800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6497_RS04840	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6497_RS04845	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6497_RS04870	COG0305	Participates in initiation and elongation during chromosome replication
L6497_RS04920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6497_RS04920	COG3320	Male sterility
L6497_RS04925	COG1309	transcriptional regulator
L6497_RS04940	COG1183	phosphatidylcholine synthase activity
L6497_RS04970	COG2376	Dihydroxyacetone kinase
L6497_RS04980	COG2376	Dihydroxyacetone kinase
L6497_RS04990	COG0457	Tetratricopeptide repeat
L6497_RS05085	COG1191	sigma factor activity
L6497_RS05095	COG2208	phosphoserine phosphatase activity
L6497_RS05100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6497_RS05105	COG0784	Response regulator, receiver
L6497_RS05105	COG2198	Histidine kinase
L6497_RS05105	COG2205	protein histidine kinase activity
L6497_RS05105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6497_RS05170	COG0420	3'-5' exonuclease activity
L6497_RS05175	COG4717	serine-type aminopeptidase activity
L6497_RS05215	COG0346	lactoylglutathione lyase activity
L6497_RS05220	COG0346	lactoylglutathione lyase activity
L6497_RS05225	COG0457	Tetratricopeptide repeat
L6497_RS05235	COG2267	carboxylic ester hydrolase activity
L6497_RS05255	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6497_RS05260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L6497_RS05270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L6497_RS05320	COG0477	Major facilitator Superfamily
L6497_RS05325	COG0477	Major facilitator Superfamily
L6497_RS05335	COG3973	AAA domain
L6497_RS05340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6497_RS05360	COG4980	gas vesicle protein
L6497_RS05365	COG0537	adenosine 5'-monophosphoramidase activity
L6497_RS05370	COG1131	(ABC) transporter
L6497_RS05375	COG4473	ABC transporter
L6497_RS05425	COG1309	transcriptional regulator
L6497_RS05435	COG3402	PFAM membrane-flanked domain
L6497_RS05440	COG3428	Bacterial PH domain
L6497_RS05480	COG3402	PFAM membrane-flanked domain
L6497_RS05485	COG3428	Bacterial PH domain
L6497_RS05490	COG2329	Antibiotic biosynthesis monooxygenase
L6497_RS05495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6497_RS05510	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6497_RS05550	COG1309	transcriptional regulator
L6497_RS05555	COG1511	domain protein
L6497_RS05575	COG1609	Transcriptional regulator
L6497_RS05585	COG1234	tRNA 3'-trailer cleavage
L6497_RS05590	COG0095	Lipoate-protein ligase
L6497_RS05600	COG0318	PFAM AMP-dependent synthetase and ligase
L6497_RS05665	COG1073	alpha beta
L6497_RS05670	COG1408	metallophosphoesterase
L6497_RS05680	COG1078	dGTPase activity
L6497_RS05690	COG1595	DNA-templated transcription, initiation
L6497_RS05695	COG2207	Transcriptional regulator
L6497_RS05695	COG3708	Transcriptional regulator
L6497_RS05700	COG2205	protein histidine kinase activity
L6497_RS05705	COG0745	RESPONSE REGULATOR receiver
L6497_RS05725	COG0501	Belongs to the peptidase M48B family
L6497_RS05730	COG0697	spore germination
L6497_RS05750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L6497_RS05755	COG2224	Isocitrate lyase
L6497_RS05780	COG4903	ComK protein
L6497_RS05785	COG0398	Pfam SNARE associated Golgi protein
L6497_RS05845	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6497_RS05870	COG0367	asparagine synthase
L6497_RS05875	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6497_RS05880	COG0753	catalase activity
L6497_RS05885	COG0004	ammonium transporteR
L6497_RS05905	COG2996	Protein conserved in bacteria
L6497_RS05915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6497_RS05925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6497_RS05940	COG0561	phosphatase activity
L6497_RS05950	COG0542	response to heat
L6497_RS05960	COG2267	carboxylic ester hydrolase activity
L6497_RS05975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6497_RS05980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6497_RS05985	COG5504	Zn-dependent protease
L6497_RS05995	COG0180	Tryptophanyl-tRNA synthetase
L6497_RS06005	COG4166	transmembrane transport
L6497_RS06010	COG0601	transmembrane transport
L6497_RS06015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6497_RS06020	COG0444	Belongs to the ABC transporter superfamily
L6497_RS06025	COG4608	Belongs to the ABC transporter superfamily
L6497_RS06030	COG0534	Mate efflux family protein
L6497_RS06035	COG4166	transmembrane transport
L6497_RS06050	COG0861	Integral membrane protein TerC family
L6497_RS06055	COG4862	establishment of competence for transformation
L6497_RS06060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6497_RS06070	COG1164	Oligoendopeptidase f
L6497_RS06085	COG2346	COG2346, Truncated hemoglobins
L6497_RS06090	COG4116	CYTH
L6497_RS06100	COG2357	RelA SpoT domain protein
L6497_RS06110	COG0564	pseudouridine synthase activity
L6497_RS06125	COG0772	Belongs to the SEDS family
L6497_RS06130	COG1216	Glycosyl transferase, family 2
L6497_RS06170	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L6497_RS06185	COG1091	dTDP-4-dehydrorhamnose reductase activity
L6497_RS06250	COG2153	protein acetylation
L6497_RS06260	COG2382	esterase
L6497_RS06275	COG5492	domain, Protein
L6497_RS06280	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6497_RS06290	COG0512	Glutamine amidotransferase of anthranilate synthase
L6497_RS06290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L6497_RS06325	COG1620	l-lactate permease
L6497_RS06330	COG5634	Uncharacterized conserved protein (DUF2278)
L6497_RS06385	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6497_RS06395	COG1476	TRANSCRIPTIONal
L6497_RS06460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6497_RS06475	COG4152	abc transporter atp-binding protein
L6497_RS06480	COG1668	transmembrane transport
L6497_RS06525	COG1192	Involved in chromosome partitioning
L6497_RS06555	COG4974	Belongs to the 'phage' integrase family
L6497_RS06570	COG2226	methyltransferase
L6497_RS06580	COG1686	Belongs to the peptidase S11 family
L6497_RS06585	COG0681	Belongs to the peptidase S26 family
L6497_RS06620	COG1012	belongs to the aldehyde dehydrogenase family
L6497_RS06630	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6497_RS06635	COG1177	transmembrane transport
L6497_RS06640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L6497_RS06650	COG2409	Drug exporters of the RND superfamily
L6497_RS06685	COG4974	Belongs to the 'phage' integrase family
L6497_RS06700	COG0564	pseudouridine synthase activity
L6497_RS06710	COG2340	Cysteine-rich secretory protein family
L6497_RS06715	COG0247	lactate metabolic process
L6497_RS06720	COG0277	FAD linked oxidase domain protein
L6497_RS06725	COG3835	regulator
L6497_RS06735	COG0745	RESPONSE REGULATOR receiver
L6497_RS06740	COG5002	protein histidine kinase activity
L6497_RS06745	COG2186	Transcriptional regulator
L6497_RS06765	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L6497_RS06775	COG2116	formate transmembrane transporter activity
L6497_RS06780	COG0861	Integral membrane protein TerC family
L6497_RS06785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6497_RS06795	COG2030	dehydratase
L6497_RS06815	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS06820	COG3243	poly(R)-hydroxyalkanoic acid synthase
L6497_RS06825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6497_RS06830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6497_RS06845	COG1840	ABC-type Fe3 transport system, periplasmic component
L6497_RS06850	COG3842	ATPase activity
L6497_RS06875	COG1349	DNA-binding transcription factor activity
L6497_RS06885	COG0235	Class ii aldolase
L6497_RS06895	COG2861	carbohydrate metabolic process
L6497_RS06905	COG3852	Histidine kinase
L6497_RS06910	COG1846	Transcriptional regulator
L6497_RS06920	COG2318	DinB family
L6497_RS06930	COG5002	protein histidine kinase activity
L6497_RS06940	COG0720	synthase
L6497_RS06955	COG4873	Protein conserved in bacteria
L6497_RS06985	COG1780	Probably involved in ribonucleotide reductase function
L6497_RS06995	COG1403	HNH endonuclease
L6497_RS07005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6497_RS07010	COG1725	Transcriptional regulator
L6497_RS07015	COG1131	(ABC) transporter
L6497_RS07025	COG1131	(ABC) transporter
L6497_RS07030	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6497_RS07045	COG1522	sequence-specific DNA binding
L6497_RS07055	COG1335	isochorismatase
L6497_RS07065	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6497_RS07070	COG2070	2-Nitropropane dioxygenase
L6497_RS07075	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6497_RS07085	COG1696	Membrane protein involved in D-alanine export
L6497_RS07110	COG0716	FMN binding
L6497_RS07125	COG3173	Aminoglycoside phosphotransferase
L6497_RS07145	COG0534	Mate efflux family protein
L6497_RS07150	COG1968	undecaprenyl-diphosphatase activity
L6497_RS07165	COG1846	Transcriptional regulator
L6497_RS07175	COG1301	dicarboxylic acid transport
L6497_RS07180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6497_RS07185	COG4709	membrane
L6497_RS07190	COG3874	Sporulation protein YtfJ
L6497_RS07210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6497_RS07215	COG0028	Belongs to the TPP enzyme family
L6497_RS07220	COG0440	acetolactate synthase activity
L6497_RS07295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6497_RS07305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6497_RS07310	COG1183	phosphatidylcholine synthase activity
L6497_RS07315	COG1368	sulfuric ester hydrolase activity
L6497_RS07325	COG0019	diaminopimelate decarboxylase activity
L6497_RS07345	COG0529	Catalyzes the synthesis of activated sulfate
L6497_RS07350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6497_RS07370	COG1648	precorrin-2 dehydrogenase activity
L6497_RS07375	COG0733	neurotransmitter:sodium symporter activity
L6497_RS07395	COG1757	Na H antiporter
L6497_RS07410	COG4758	membrane
L6497_RS07415	COG4585	Histidine kinase
L6497_RS07420	COG2197	response regulator
L6497_RS07430	COG1114	Component of the transport system for branched-chain amino acids
L6497_RS07440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6497_RS07480	COG0730	response to heat
L6497_RS07485	COG0306	phosphate transporter
L6497_RS07490	COG1392	Phosphate transport regulator
L6497_RS07495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6497_RS07510	COG3852	Histidine kinase
L6497_RS07515	COG1801	Protein of unknown function DUF72
L6497_RS07525	COG0582	viral genome integration into host DNA
L6497_RS07530	COG5002	protein histidine kinase activity
L6497_RS07545	COG0392	lysyltransferase activity
L6497_RS07545	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L6497_RS07560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6497_RS07565	COG1686	Belongs to the peptidase S11 family
L6497_RS07570	COG2715	membrane protein required for spore maturation
L6497_RS07575	COG0700	Nucleoside recognition
L6497_RS07580	COG1187	pseudouridine synthase activity
L6497_RS07590	COG1333	cytochrome c biogenesis protein
L6497_RS07595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6497_RS07600	COG0745	RESPONSE REGULATOR receiver
L6497_RS07605	COG5002	protein histidine kinase activity
L6497_RS07610	COG2096	Adenosyltransferase
L6497_RS07615	COG4942	peptidase
L6497_RS07625	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L6497_RS07630	COG1141	Ferredoxin
L6497_RS07640	COG0514	ATP-dependent DNA helicase (RecQ)
L6497_RS07645	COG1266	CAAX protease self-immunity
L6497_RS07655	COG1408	metallophosphoesterase
L6497_RS07665	COG4862	establishment of competence for transformation
L6497_RS07670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L6497_RS07690	COG0492	ferredoxin-NADP+ reductase activity
L6497_RS07695	COG0252	asparaginase activity
L6497_RS07765	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6497_RS07780	COG0142	geranyltranstransferase activity
L6497_RS07790	COG0142	geranyltranstransferase activity
L6497_RS07810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6497_RS07815	COG0457	Tetratricopeptide repeat
L6497_RS07835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L6497_RS07845	COG4347	Protein of unknown function (DUF1405)
L6497_RS07860	COG2738	Putative neutral zinc metallopeptidase
L6497_RS07870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6497_RS07875	COG1694	Mazg nucleotide pyrophosphohydrolase
L6497_RS07890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6497_RS07895	COG0438	transferase activity, transferring glycosyl groups
L6497_RS07930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L6497_RS07930	COG1199	ATP-dependent helicase activity
L6497_RS07950	COG3935	DnaD domain protein
L6497_RS07955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L6497_RS07965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6497_RS07965	COG4499	WXG100 protein secretion system (Wss), protein YukC
L6497_RS08025	COG0116	Belongs to the methyltransferase superfamily
L6497_RS08035	COG1199	ATP-dependent helicase activity
L6497_RS08040	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L6497_RS08050	COG3173	Aminoglycoside phosphotransferase
L6497_RS08055	COG0024	Methionine aminopeptidase
L6497_RS08065	COG2233	PERMEase
L6497_RS08070	COG2311	Membrane
L6497_RS08075	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6497_RS08085	COG0456	acetyltransferase
L6497_RS08120	COG0754	glutathionylspermidine amidase activity
L6497_RS08135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6497_RS08150	COG0454	-acetyltransferase
L6497_RS08170	COG0328	RNA-DNA hybrid ribonuclease activity
L6497_RS08205	COG3403	YqcI/YcgG family
L6497_RS08210	COG1280	lysine exporter protein (LysE YggA)
L6497_RS08225	COG3162	membrane
L6497_RS08230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6497_RS08235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6497_RS08245	COG0475	glutathione-regulated potassium exporter activity
L6497_RS08250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6497_RS08255	COG4978	Transcriptional regulator
L6497_RS08255	COG0789	Transcriptional regulator
L6497_RS08265	COG2323	membrane
L6497_RS08270	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L6497_RS08325	COG1923	regulation of RNA biosynthetic process
L6497_RS08340	COG1360	Flagellar Motor Protein
L6497_RS08345	COG2201	protein-glutamate methylesterase activity
L6497_RS08350	COG2198	Histidine kinase
L6497_RS08350	COG0643	Histidine kinase
L6497_RS08355	COG1776	CheC inhibitor of MCP methylation
L6497_RS08355	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6497_RS08370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6497_RS08390	COG1256	bacterial-type flagellum assembly
L6497_RS08395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L6497_RS08415	COG1815	bacterial-type flagellum-dependent cell motility
L6497_RS08420	COG1558	bacterial-type flagellum-dependent cell motility
L6497_RS08430	COG1766	The M ring may be actively involved in energy transduction
L6497_RS08435	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6497_RS08445	COG1157	protein secretion by the type III secretion system
L6497_RS08480	COG0784	Response regulator, receiver
L6497_RS08480	COG0835	chemotaxis
L6497_RS08500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L6497_RS08505	COG0741	lytic transglycosylase activity
L6497_RS08515	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6497_RS08520	COG1776	CheC inhibitor of MCP methylation
L6497_RS08520	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6497_RS08530	COG1338	Plays a role in the flagellum-specific transport system
L6497_RS08535	COG1987	bacterial-type flagellum assembly
L6497_RS08545	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6497_RS08550	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6497_RS08555	COG1419	protein localization to endoplasmic reticulum
L6497_RS08560	COG4786	Flagellar basal body rod
L6497_RS08565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6497_RS08610	COG2329	Antibiotic biosynthesis monooxygenase
L6497_RS08635	COG0583	DNA-binding transcription factor activity
L6497_RS08640	COG3842	ATPase activity
L6497_RS08645	COG0725	ABC transporter, periplasmic molybdate-binding protein
L6497_RS08655	COG1234	tRNA 3'-trailer cleavage
L6497_RS08670	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS08685	COG1686	Belongs to the peptidase S11 family
L6497_RS08695	COG0406	alpha-ribazole phosphatase activity
L6497_RS08715	COG1846	Transcriptional regulator
L6497_RS08725	COG0367	asparagine synthase
L6497_RS08755	COG1802	Transcriptional regulator
L6497_RS08760	COG0697	spore germination
L6497_RS08765	COG0523	cobalamin synthesis protein
L6497_RS08770	COG0701	Predicted permease
L6497_RS08785	COG1757	Na H antiporter
L6497_RS08790	COG0114	fumarate hydratase activity
L6497_RS08810	COG3340	Belongs to the peptidase S51 family
L6497_RS08830	COG0785	Cytochrome C biogenesis protein
L6497_RS08860	COG2733	membrane
L6497_RS08895	COG1131	(ABC) transporter
L6497_RS08910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6497_RS08915	COG0528	UMP kinase activity
L6497_RS08925	COG1027	Aspartate ammonia-lyase
L6497_RS08930	COG0281	malic enzyme
L6497_RS08935	COG4191	Histidine kinase
L6497_RS08940	COG0784	Response regulator, receiver
L6497_RS08945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6497_RS08965	COG3620	sequence-specific DNA binding
L6497_RS08990	COG1051	belongs to the nudix hydrolase family
L6497_RS09015	COG1966	Carbon starvation protein
L6497_RS09025	COG0477	Major facilitator Superfamily
L6497_RS09040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L6497_RS09045	COG4166	transmembrane transport
L6497_RS09050	COG2223	nitrite transmembrane transporter activity
L6497_RS09055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6497_RS09070	COG2244	polysaccharide biosynthetic process
L6497_RS09075	COG0733	neurotransmitter:sodium symporter activity
L6497_RS09085	COG5566	PFAM Mor transcription activator
L6497_RS09090	COG2323	membrane
L6497_RS09105	COG2084	Dehydrogenase
L6497_RS09120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6497_RS09130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6497_RS09135	COG0028	Belongs to the TPP enzyme family
L6497_RS09145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6497_RS09155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6497_RS09180	COG2814	Major facilitator Superfamily
L6497_RS09185	COG3384	dioxygenase
L6497_RS09205	COG3279	Response regulator of the LytR AlgR family
L6497_RS09210	COG0427	acetyl-CoA hydrolase
L6497_RS09245	COG4166	transmembrane transport
L6497_RS09270	COG0535	radical SAM domain protein
L6497_RS09275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6497_RS09280	COG0745	RESPONSE REGULATOR receiver
L6497_RS09300	COG1914	H( )-stimulated, divalent metal cation uptake system
L6497_RS09315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6497_RS09320	COG0531	amino acid
L6497_RS09350	COG0714	Associated with various cellular activities
L6497_RS09360	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L6497_RS09385	COG2390	Transcriptional regulator
L6497_RS09395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6497_RS09400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L6497_RS09435	COG0006	proline dipeptidase activity
L6497_RS09440	COG2132	Multicopper oxidase
L6497_RS09455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6497_RS09475	COG1114	Component of the transport system for branched-chain amino acids
L6497_RS09485	COG1276	copper resistance
L6497_RS09485	COG2372	response to copper ion
L6497_RS09490	COG4549	nuclear export factor GLE1
L6497_RS09495	COG0697	spore germination
L6497_RS09500	COG0583	DNA-binding transcription factor activity
L6497_RS09505	COG1959	2 iron, 2 sulfur cluster binding
L6497_RS09510	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L6497_RS09515	COG0778	Nitroreductase
L6497_RS09525	COG0628	permease
L6497_RS09535	COG1231	oxidoreductase activity
L6497_RS09540	COG0523	cobalamin synthesis protein
L6497_RS09555	COG0318	PFAM AMP-dependent synthetase and ligase
L6497_RS09560	COG2030	dehydratase
L6497_RS09565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6497_RS09575	COG0411	ABC transporter
L6497_RS09595	COG0583	DNA-binding transcription factor activity
L6497_RS09605	COG1942	4-Oxalocrotonate Tautomerase
L6497_RS09625	COG1271	oxidase subunit
L6497_RS09630	COG1294	oxidase, subunit
L6497_RS09635	COG4988	ABC transporter
L6497_RS09640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L6497_RS09655	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6497_RS09660	COG1686	Belongs to the peptidase S11 family
L6497_RS09675	COG0791	NLP P60 protein
L6497_RS09675	COG1388	LysM domain
L6497_RS09685	COG1132	(ABC) transporter
L6497_RS09690	COG0745	RESPONSE REGULATOR receiver
L6497_RS09695	COG2205	protein histidine kinase activity
L6497_RS09705	COG0300	oxidoreductase activity
L6497_RS09710	COG4122	O-methyltransferase activity
L6497_RS09740	COG0460	homoserine dehydrogenase
L6497_RS09765	COG1316	TRANSCRIPTIONal
L6497_RS09775	COG0745	RESPONSE REGULATOR receiver
L6497_RS09780	COG5002	protein histidine kinase activity
L6497_RS09795	COG1285	pathogenesis
L6497_RS09800	COG1247	-acetyltransferase
L6497_RS09820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6497_RS09830	COG1082	Xylose isomerase domain protein TIM barrel
L6497_RS09840	COG2814	Major facilitator Superfamily
L6497_RS09845	COG1279	arginine transmembrane transporter activity
L6497_RS09850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6497_RS09860	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6497_RS09895	COG0577	efflux transmembrane transporter activity
L6497_RS09900	COG2002	toxin-antitoxin pair type II binding
L6497_RS09905	COG1404	Belongs to the peptidase S8 family
L6497_RS09910	COG0640	Transcriptional regulator
L6497_RS09915	COG0667	Aldo Keto reductase
L6497_RS09920	COG2814	Major facilitator Superfamily
L6497_RS09945	COG0840	transmembrane signaling receptor activity
L6497_RS09960	COG3949	Membrane
L6497_RS09965	COG0783	Belongs to the Dps family
L6497_RS09980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6497_RS09990	COG1231	oxidoreductase activity
L6497_RS10000	COG4989	oxidoreductase activity
L6497_RS10005	COG0523	cobalamin synthesis protein
L6497_RS10010	COG0456	acetyltransferase
L6497_RS10030	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6497_RS10030	COG3443	Belongs to the bacterial solute-binding protein 9 family
L6497_RS10040	COG0702	epimerase
L6497_RS10050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6497_RS10060	COG4166	transmembrane transport
L6497_RS10075	COG0406	alpha-ribazole phosphatase activity
L6497_RS10085	COG5337	Spore coat protein CotH
L6497_RS10090	COG1051	belongs to the nudix hydrolase family
L6497_RS10095	COG0586	Pfam SNARE associated Golgi protein
L6497_RS10100	COG2244	polysaccharide biosynthetic process
L6497_RS10110	COG0701	Predicted permease
L6497_RS10115	COG3689	TIGRFAM TIGR03943 family protein
L6497_RS10120	COG1607	acyl-coa hydrolase
L6497_RS10130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6497_RS10145	COG0702	epimerase
L6497_RS10150	COG2839	Protein conserved in bacteria
L6497_RS10155	COG1253	flavin adenine dinucleotide binding
L6497_RS10170	COG1114	Component of the transport system for branched-chain amino acids
L6497_RS10175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6497_RS10195	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6497_RS10205	COG1876	peptidase activity
L6497_RS10220	COG2211	Major facilitator Superfamily
L6497_RS10235	COG2368	4-hydroxyphenylacetate
L6497_RS10245	COG0196	riboflavin kinase activity
L6497_RS10260	COG0251	oxidation-reduction process
L6497_RS10270	COG3971	2-oxopent-4-enoate hydratase activity
L6497_RS10290	COG1942	4-Oxalocrotonate Tautomerase
L6497_RS10300	COG0561	phosphatase activity
L6497_RS10310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6497_RS10320	COG4974	Belongs to the 'phage' integrase family
L6497_RS10355	COG4106	trans-aconitate 2-methyltransferase activity
L6497_RS10370	COG1819	glycosyl
L6497_RS10375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6497_RS10380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6497_RS10410	COG0456	acetyltransferase
L6497_RS10495	COG3874	Sporulation protein YtfJ
L6497_RS10520	COG2226	methyltransferase
L6497_RS10545	COG0346	lactoylglutathione lyase activity
L6497_RS10555	COG0604	alcohol dehydrogenase
L6497_RS10560	COG1595	DNA-templated transcription, initiation
L6497_RS10575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L6497_RS10575	COG0426	domain, Protein
L6497_RS10585	COG0386	Belongs to the glutathione peroxidase family
L6497_RS10595	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
L6497_RS10600	COG0714	Associated with various cellular activities
L6497_RS10615	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
L6497_RS10620	COG1140	nitrate reductase beta subunit
L6497_RS10625	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
L6497_RS10630	COG2181	nitrate reductase activity
L6497_RS10635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6497_RS10640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L6497_RS10645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6497_RS10650	COG0303	'Molybdopterin
L6497_RS10655	COG0314	molybdopterin synthase activity
L6497_RS10665	COG2223	nitrite transmembrane transporter activity
L6497_RS10675	COG1648	precorrin-2 dehydrogenase activity
L6497_RS10685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6497_RS10685	COG1587	Uroporphyrinogen-III synthase
L6497_RS10690	COG2146	nitrite reductase [NAD(P)H] activity
L6497_RS10695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6497_RS10700	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
L6497_RS10725	COG2359	stage V sporulation protein S
L6497_RS10780	COG1418	mRNA catabolic process
L6497_RS10785	COG0488	(ABC) transporter
L6497_RS10800	COG0629	single-stranded DNA binding
L6497_RS10815	COG1413	lyase activity
L6497_RS10830	COG2521	methyltransferase
L6497_RS10830	COG2136	Putative SAM-dependent methyltransferase
L6497_RS10875	COG0017	Asparaginyl-tRNA synthetase
L6497_RS10895	COG1674	ftsk spoiiie
L6497_RS10980	COG1929	Belongs to the glycerate kinase type-1 family
L6497_RS10985	COG0471	metal ion transport
L6497_RS10990	COG0745	RESPONSE REGULATOR receiver
L6497_RS11010	COG0733	neurotransmitter:sodium symporter activity
L6497_RS11035	COG2610	gluconate transmembrane transporter activity
L6497_RS11040	COG1454	alcohol dehydrogenase
L6497_RS11045	COG1794	racemase activity, acting on amino acids and derivatives
L6497_RS11055	COG0456	acetyltransferase
L6497_RS11060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L6497_RS11070	COG1131	(ABC) transporter
L6497_RS11075	COG4473	ABC transporter
L6497_RS11085	COG0546	phosphoglycolate phosphatase activity
L6497_RS11105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6497_RS11110	COG3250	beta-galactosidase activity
L6497_RS11125	COG0768	penicillin binding
L6497_RS11135	COG0204	Acyl-transferase
L6497_RS11140	COG1272	protein, Hemolysin III
L6497_RS11150	COG0805	protein transport
L6497_RS11160	COG1307	EDD domain protein, DegV family
L6497_RS11165	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L6497_RS11170	COG1999	signal sequence binding
L6497_RS11175	COG0071	Belongs to the small heat shock protein (HSP20) family
L6497_RS11180	COG0367	asparagine synthase
L6497_RS11200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6497_RS11205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6497_RS11225	COG1335	isochorismatase
L6497_RS11230	COG1051	belongs to the nudix hydrolase family
L6497_RS11240	COG0668	transmembrane transport
L6497_RS11245	COG4585	Histidine kinase
L6497_RS11245	COG2203	Gaf domain
L6497_RS11250	COG2197	response regulator
L6497_RS11260	COG1064	alcohol dehydrogenase
L6497_RS11285	COG1070	Carbohydrate kinase
L6497_RS11290	COG1070	Carbohydrate kinase
L6497_RS11320	COG1125	glycine betaine transport
L6497_RS11320	COG0517	IMP dehydrogenase activity
L6497_RS11325	COG1174	glycine betaine transport
L6497_RS11360	COG1253	flavin adenine dinucleotide binding
L6497_RS11365	COG1012	belongs to the aldehyde dehydrogenase family
L6497_RS11370	COG5506	Protein of unknown function (DUF1694)
L6497_RS11385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6497_RS11390	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L6497_RS11395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L6497_RS11400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6497_RS11405	COG0456	acetyltransferase
L6497_RS11410	COG3829	transcription factor binding
L6497_RS11415	COG1509	lysine 2,3-aminomutase activity
L6497_RS11450	COG3064	Membrane
L6497_RS11450	COG0515	serine threonine protein kinase
L6497_RS11450	COG4991	sh3 domain protein
L6497_RS11460	COG0671	phosphoesterase, PA-phosphatase related
L6497_RS11465	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6497_RS11470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6497_RS11530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6497_RS11565	COG0300	oxidoreductase activity
L6497_RS11585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6497_RS11585	COG4499	WXG100 protein secretion system (Wss), protein YukC
L6497_RS11595	COG2814	Major facilitator Superfamily
L6497_RS11600	COG4841	protein insertion into membrane
L6497_RS11605	COG0372	Belongs to the citrate synthase family
L6497_RS11610	COG2079	MmgE PrpD family protein
L6497_RS11615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L6497_RS11620	COG1960	acyl-CoA dehydrogenase activity
L6497_RS11635	COG1280	lysine exporter protein (LysE YggA)
L6497_RS11640	COG1024	Enoyl-CoA hydratase
L6497_RS11655	COG0420	3'-5' exonuclease activity
L6497_RS11660	COG0419	ATPase involved in DNA repair
L6497_RS11680	COG2223	nitrite transmembrane transporter activity
L6497_RS11685	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS11690	COG1169	isochorismate synthase
L6497_RS11695	COG1021	2,3-dihydroxybenzoate-AMP ligase
L6497_RS11700	COG3433	isochorismatase activity
L6497_RS11700	COG1535	isochorismatase
L6497_RS11705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6497_RS11710	COG3251	PFAM MbtH domain protein
L6497_RS11715	COG2814	Major facilitator Superfamily
L6497_RS11730	COG0776	regulation of translation
L6497_RS11740	COG2318	DinB family
L6497_RS11750	COG1115	amino acid carrier protein
L6497_RS11765	COG2329	Antibiotic biosynthesis monooxygenase
L6497_RS11770	COG1187	pseudouridine synthase activity
L6497_RS11775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6497_RS11785	COG1136	(ABC) transporter
L6497_RS11795	COG0596	Alpha beta hydrolase
L6497_RS11800	COG2814	Major facilitator Superfamily
L6497_RS11820	COG2226	methyltransferase
L6497_RS11865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6497_RS11900	COG1247	-acetyltransferase
L6497_RS11930	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6497_RS11940	COG2226	methyltransferase
L6497_RS11945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6497_RS11955	COG1278	Cold shock
L6497_RS11970	COG0010	Belongs to the arginase family
L6497_RS11980	COG0583	DNA-binding transcription factor activity
L6497_RS11985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6497_RS12000	COG0583	DNA-binding transcription factor activity
L6497_RS12005	COG2258	MOSC domain
L6497_RS12020	COG1132	(ABC) transporter
L6497_RS12025	COG1132	(ABC) transporter
L6497_RS12045	COG1396	sequence-specific DNA binding
L6497_RS12075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6497_RS12085	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
L6497_RS12090	COG1595	DNA-templated transcription, initiation
L6497_RS12115	COG1649	PFAM Uncharacterised BCR, COG1649
L6497_RS12140	COG2971	BadF BadG BcrA BcrD
L6497_RS12150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L6497_RS12215	COG1309	transcriptional regulator
L6497_RS12230	COG0577	efflux transmembrane transporter activity
L6497_RS12230	COG1136	(ABC) transporter
L6497_RS12235	COG0500	methyltransferase
L6497_RS12235	COG3615	Tellurite resistance protein tehB
L6497_RS12335	COG1846	Transcriptional regulator
L6497_RS12370	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6497_RS12385	COG1595	DNA-templated transcription, initiation
L6497_RS12395	COG0768	penicillin binding
L6497_RS12410	COG0768	penicillin binding
L6497_RS12415	COG2367	Beta-lactamase
L6497_RS12420	COG1408	metallophosphoesterase
L6497_RS12425	COG0675	Transposase, IS605 OrfB family
L6497_RS12455	COG1960	acyl-CoA dehydrogenase activity
L6497_RS12460	COG0439	Biotin carboxylase
L6497_RS12465	COG0511	ligase activity, forming carbon-carbon bonds
L6497_RS12470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6497_RS12475	COG1024	Enoyl-CoA hydratase
L6497_RS12480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L6497_RS12485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6497_RS12495	COG1247	-acetyltransferase
L6497_RS12500	COG0572	uridine kinase
L6497_RS12510	COG2318	DinB family
L6497_RS12515	COG1686	Belongs to the peptidase S11 family
L6497_RS12540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L6497_RS12560	COG3227	Zinc metalloprotease (Elastase)
L6497_RS12580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6497_RS12580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6497_RS12605	COG2814	Major facilitator Superfamily
L6497_RS12615	COG2226	methyltransferase
L6497_RS12630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6497_RS12650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6497_RS12670	COG1063	alcohol dehydrogenase
L6497_RS12690	COG3386	PFAM SMP-30 Gluconolaconase
L6497_RS12700	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
L6497_RS12705	COG3773	Cell wall hydrolase
L6497_RS12715	COG0745	RESPONSE REGULATOR receiver
L6497_RS12720	COG2205	protein histidine kinase activity
L6497_RS12730	COG0488	(ABC) transporter
L6497_RS12745	COG1136	(ABC) transporter
L6497_RS12750	COG0577	efflux transmembrane transporter activity
L6497_RS12770	COG0460	homoserine dehydrogenase
L6497_RS12775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6497_RS12785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6497_RS12860	COG2124	cytochrome p450
L6497_RS12895	COG0561	phosphatase activity
L6497_RS12900	COG5002	protein histidine kinase activity
L6497_RS12905	COG0768	penicillin binding
L6497_RS12910	COG1819	glycosyl
L6497_RS12915	COG1794	racemase activity, acting on amino acids and derivatives
L6497_RS12950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6497_RS12955	COG0604	alcohol dehydrogenase
L6497_RS12960	COG0671	phosphoesterase, PA-phosphatase related
L6497_RS12965	COG0768	penicillin binding
L6497_RS12985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6497_RS13020	COG0693	protein deglycase activity
L6497_RS13040	COG2814	Major facilitator Superfamily
L6497_RS13060	COG0584	glycerophosphoryl diester phosphodiesterase
L6497_RS13080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6497_RS13085	COG0697	spore germination
L6497_RS13110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6497_RS13120	COG2223	nitrite transmembrane transporter activity
L6497_RS13125	COG2816	NAD+ diphosphatase activity
L6497_RS13130	COG0592	DNA-directed DNA polymerase activity
L6497_RS13135	COG1051	belongs to the nudix hydrolase family
L6497_RS13160	COG0406	alpha-ribazole phosphatase activity
L6497_RS13170	COG3878	Protein conserved in bacteria
L6497_RS13195	COG4667	esterase of the alpha-beta hydrolase superfamily
L6497_RS13220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6497_RS13235	COG0322	excinuclease ABC activity
L6497_RS13275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6497_RS13300	COG1011	Hydrolase
L6497_RS13320	COG1523	belongs to the glycosyl hydrolase 13 family
L6497_RS13325	COG3227	Zinc metalloprotease (Elastase)
L6497_RS13345	COG0346	lactoylglutathione lyase activity
L6497_RS13350	COG0201	protein transport
L6497_RS13360	COG0697	spore germination
L6497_RS13365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6497_RS13400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6497_RS13415	COG2959	enzyme of heme biosynthesis
L6497_RS13450	COG1309	transcriptional regulator
L6497_RS13490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6497_RS13495	COG1349	DNA-binding transcription factor activity
L6497_RS13515	COG1959	2 iron, 2 sulfur cluster binding
L6497_RS13530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6497_RS13535	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6497_RS13540	COG0022	dehydrogenase e1 component
L6497_RS13545	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6497_RS13555	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS13560	COG0456	acetyltransferase
L6497_RS13560	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6497_RS13565	COG0572	uridine kinase
L6497_RS13575	COG0494	nUDIX hydrolase
L6497_RS13600	COG4176	ABC-type proline glycine betaine transport system permease component
L6497_RS13605	COG0517	IMP dehydrogenase activity
L6497_RS13605	COG4175	Glycine betaine
L6497_RS13635	COG2153	protein acetylation
L6497_RS13640	COG3397	chitin binding
L6497_RS13655	COG2205	protein histidine kinase activity
L6497_RS13665	COG2315	Protein conserved in bacteria
L6497_RS13670	COG2153	protein acetylation
L6497_RS13675	COG0658	competence protein
L6497_RS13675	COG2333	competence protein COMEC
L6497_RS13725	COG3973	AAA domain
L6497_RS13745	COG0514	ATP-dependent DNA helicase (RecQ)
L6497_RS13770	COG4637	Psort location Cytoplasmic, score
L6497_RS13795	COG3397	chitin binding
L6497_RS13810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6497_RS13815	COG1115	amino acid carrier protein
L6497_RS13820	COG1012	belongs to the aldehyde dehydrogenase family
L6497_RS13825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6497_RS13835	COG3938	Belongs to the proline racemase family
L6497_RS13840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6497_RS13880	COG0586	Pfam SNARE associated Golgi protein
L6497_RS13895	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6497_RS13900	COG0519	Catalyzes the synthesis of GMP from XMP
L6497_RS13905	COG4166	transmembrane transport
L6497_RS13915	COG4948	Mandelate Racemase Muconate Lactonizing
L6497_RS13960	COG2936	dipeptidyl-peptidase activity
L6497_RS13965	COG5002	protein histidine kinase activity
L6497_RS13970	COG0745	RESPONSE REGULATOR receiver
L6497_RS14000	COG1164	Oligoendopeptidase f
L6497_RS14010	COG1522	sequence-specific DNA binding
L6497_RS14015	COG1307	EDD domain protein, DegV family
L6497_RS14050	COG2814	Major facilitator Superfamily
L6497_RS14060	COG1664	Polymer-forming cytoskeletal
L6497_RS14065	COG0789	Transcriptional regulator
L6497_RS14070	COG4533	DNA binding
L6497_RS14075	COG0477	Major facilitator Superfamily
L6497_RS14075	COG2814	Major facilitator Superfamily
L6497_RS14095	COG2261	transglycosylase associated protein
L6497_RS14140	COG0436	Aminotransferase
L6497_RS14145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L6497_RS14155	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
L6497_RS14170	COG1131	(ABC) transporter
L6497_RS14220	COG0628	permease
L6497_RS14235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6497_RS14240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6497_RS14245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6497_RS14260	COG2816	NAD+ diphosphatase activity
L6497_RS14280	COG2746	aminoglycoside 3-N-acetyltransferase activity
L6497_RS14305	COG0697	spore germination
L6497_RS14310	COG2318	DinB family
L6497_RS14350	COG0861	Integral membrane protein TerC family
L6497_RS14355	COG1368	sulfuric ester hydrolase activity
L6497_RS14360	COG0488	(ABC) transporter
L6497_RS14370	COG2409	Drug exporters of the RND superfamily
L6497_RS14370	COG1033	growth of symbiont in host cell
L6497_RS14375	COG1309	transcriptional regulator
L6497_RS14390	COG0287	Prephenate dehydrogenase
L6497_RS14395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6497_RS14405	COG1605	Chorismate mutase
L6497_RS14405	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L6497_RS14440	COG3584	3D domain protein
L6497_RS14440	COG1388	LysM domain
L6497_RS14450	COG2610	gluconate transmembrane transporter activity
L6497_RS14455	COG1024	Enoyl-CoA hydratase
L6497_RS14465	COG3290	protein histidine kinase activity
L6497_RS14465	COG3829	transcription factor binding
L6497_RS14480	COG1879	ABC-type sugar transport system periplasmic component
L6497_RS14490	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6497_RS14500	COG2390	Transcriptional regulator
L6497_RS14505	COG1070	Carbohydrate kinase
L6497_RS14540	COG2329	Antibiotic biosynthesis monooxygenase
L6497_RS14560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6497_RS14570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L6497_RS14575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6497_RS14580	COG4187	Peptidase family M20/M25/M40
L6497_RS14585	COG1414	Transcriptional regulator
L6497_RS14590	COG0833	amino acid
L6497_RS14615	COG1690	Belongs to the RtcB family
L6497_RS14620	COG3239	Fatty acid desaturase
L6497_RS14625	COG1785	Belongs to the alkaline phosphatase family
L6497_RS14635	COG3655	Transcriptional regulator
L6497_RS14650	COG4377	Putative membrane peptidase family (DUF2324)
L6497_RS14660	COG3279	Response regulator of the LytR AlgR family
L6497_RS14685	COG0346	lactoylglutathione lyase activity
L6497_RS14705	COG0714	Associated with various cellular activities
L6497_RS14750	COG0463	Glycosyl transferase, family 2
L6497_RS14765	COG0753	catalase activity
L6497_RS14775	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L6497_RS14805	COG0778	Nitroreductase
L6497_RS14810	COG1846	Transcriptional regulator
L6497_RS14845	COG1725	Transcriptional regulator
L6497_RS14860	COG0577	efflux transmembrane transporter activity
L6497_RS14860	COG1136	(ABC) transporter
L6497_RS14885	COG2207	Transcriptional regulator
L6497_RS14890	COG0456	acetyltransferase
L6497_RS14910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6497_RS14950	COG0730	response to heat
L6497_RS14960	COG0833	amino acid
L6497_RS14970	COG4335	DNA alkylation repair
L6497_RS15000	COG0768	penicillin binding
L6497_RS15005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L6497_RS15030	COG1984	allophanate hydrolase subunit 2
L6497_RS15035	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L6497_RS15040	COG1414	Transcriptional regulator
L6497_RS15050	COG3142	Participates in the control of copper homeostasis
L6497_RS15055	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6497_RS15060	COG0640	Transcriptional regulator
L6497_RS15070	COG1960	acyl-CoA dehydrogenase activity
L6497_RS15085	COG3314	Sporulation integral membrane protein YlbJ
L6497_RS15110	COG0574	Belongs to the PEP-utilizing enzyme family
L6497_RS15110	COG3848	Pyruvate phosphate dikinase
L6497_RS15115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6497_RS15130	COG5577	PFAM Coat F domain
L6497_RS15135	COG3403	YqcI/YcgG family
L6497_RS15140	COG1280	lysine exporter protein (LysE YggA)
L6497_RS15145	COG1113	amino acid transport
L6497_RS15175	COG1063	alcohol dehydrogenase
L6497_RS15195	COG4974	Belongs to the 'phage' integrase family
L6497_RS15240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L6497_RS15285	COG0737	Belongs to the 5'-nucleotidase family
L6497_RS15290	COG3344	reverse transcriptase
L6497_RS15295	COG2329	Antibiotic biosynthesis monooxygenase
L6497_RS15305	COG0598	Magnesium transport protein CorA
L6497_RS15345	COG0415	Belongs to the DNA photolyase family
L6497_RS15350	COG0288	reversible hydration of carbon dioxide
L6497_RS15360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6497_RS15365	COG5609	conserved protein (DUF2294)
L6497_RS15380	COG0714	Associated with various cellular activities
L6497_RS15390	COG1575	Belongs to the MenA family. Type 1 subfamily
L6497_RS15395	COG2267	carboxylic ester hydrolase activity
L6497_RS15405	COG1136	(ABC) transporter
L6497_RS15410	COG0577	efflux transmembrane transporter activity
L6497_RS15425	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6497_RS15430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6497_RS15435	COG1121	(ABC) transporter
L6497_RS15460	COG0798	PFAM Bile acid sodium symporter
L6497_RS15465	COG0346	lactoylglutathione lyase activity
L6497_RS15470	COG0640	Transcriptional regulator
L6497_RS15485	COG0443	Heat shock 70 kDa protein
L6497_RS15505	COG0346	lactoylglutathione lyase activity
L6497_RS15545	COG2814	Major facilitator Superfamily
L6497_RS15570	COG0745	RESPONSE REGULATOR receiver
L6497_RS15575	COG3850	Histidine kinase
L6497_RS15575	COG5002	protein histidine kinase activity
L6497_RS15600	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L6497_RS15625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6497_RS15630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6497_RS15640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6497_RS15655	COG2309	aminopeptidase activity
L6497_RS15665	COG0789	Transcriptional regulator
L6497_RS15670	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L6497_RS15690	COG0577	efflux transmembrane transporter activity
L6497_RS15705	COG3850	Histidine kinase
L6497_RS15705	COG5002	protein histidine kinase activity
L6497_RS15715	COG2364	Membrane
L6497_RS15720	COG1846	Transcriptional regulator
L6497_RS15725	COG0456	acetyltransferase
L6497_RS15730	COG2808	Putative FMN-binding domain
L6497_RS15735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6497_RS15740	COG2271	Major facilitator Superfamily
L6497_RS15745	COG1556	Lactate utilization protein
L6497_RS15750	COG1139	Iron-sulfur cluster binding protein
L6497_RS15760	COG0583	DNA-binding transcription factor activity
L6497_RS15780	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6497_RS15795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6497_RS15815	COG1595	DNA-templated transcription, initiation
L6497_RS15830	COG0662	Cupin 2, conserved barrel domain protein
L6497_RS15835	COG2207	Transcriptional regulator
L6497_RS15835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6497_RS15865	COG3409	Peptidoglycan-binding domain 1 protein
L6497_RS15865	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6497_RS15905	COG0477	Major facilitator Superfamily
L6497_RS15915	COG1846	Transcriptional regulator
L6497_RS15920	COG2814	Major facilitator Superfamily
L6497_RS15930	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6497_RS15935	COG1131	(ABC) transporter
L6497_RS15955	COG2076	Multidrug Resistance protein
L6497_RS15960	COG1309	transcriptional regulator
L6497_RS15975	COG2031	fatty acid transporter
L6497_RS15985	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6497_RS16015	COG1122	ATPase activity
L6497_RS16020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6497_RS16035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6497_RS16040	COG1288	antiporter activity
L6497_RS16045	COG2356	endonuclease I
L6497_RS16050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L6497_RS16060	COG2197	response regulator
L6497_RS16080	COG1733	regulation of RNA biosynthetic process
L6497_RS16085	COG0778	Nitroreductase
L6497_RS16115	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS16125	COG1131	(ABC) transporter
L6497_RS16150	COG1011	Hydrolase
L6497_RS16170	COG2365	Tyrosine phosphatase family
L6497_RS16195	COG0346	lactoylglutathione lyase activity
L6497_RS16200	COG1940	carbohydrate kinase activity
L6497_RS16205	COG0110	maltose O-acetyltransferase activity
L6497_RS16210	COG0628	permease
L6497_RS16230	COG2226	methyltransferase
L6497_RS16240	COG0477	Major facilitator Superfamily
L6497_RS16270	COG1253	flavin adenine dinucleotide binding
L6497_RS16275	COG0789	Transcriptional regulator
L6497_RS16280	COG0697	spore germination
L6497_RS16285	COG1357	PFAM Pentapeptide repeats (8 copies)
L6497_RS16290	COG3813	Protein conserved in bacteria
L6497_RS16295	COG2706	6-phosphogluconolactonase activity
L6497_RS16310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L6497_RS16315	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L6497_RS16325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L6497_RS16365	COG0814	amino acid
L6497_RS16390	COG1393	Belongs to the ArsC family
L6497_RS16400	COG2188	Transcriptional regulator
L6497_RS16405	COG0673	inositol 2-dehydrogenase activity
L6497_RS16420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6497_RS16440	COG0384	phenazine biosynthesis protein PhzF
L6497_RS16455	COG0318	PFAM AMP-dependent synthetase and ligase
L6497_RS16460	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6497_RS16465	COG1733	regulation of RNA biosynthetic process
L6497_RS16485	COG1191	sigma factor activity
L6497_RS16495	COG1266	CAAX protease self-immunity
L6497_RS16500	COG1309	transcriptional regulator
L6497_RS16520	COG3152	Membrane
L6497_RS16565	COG1151	hydroxylamine reductase activity
L6497_RS16575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6497_RS16580	COG3757	hydrolase, family 25
L6497_RS16580	COG3409	Peptidoglycan-binding domain 1 protein
L6497_RS16615	COG2072	flavoprotein involved in K transport
L6497_RS16660	COG1113	amino acid transport
L6497_RS16665	COG2814	Major facilitator Superfamily
L6497_RS16690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6497_RS16695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6497_RS16710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6497_RS16715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6497_RS16720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6497_RS16725	COG3739	integral membrane protein
L6497_RS16730	COG0384	phenazine biosynthesis protein PhzF
L6497_RS16750	COG0583	DNA-binding transcription factor activity
L6497_RS16770	COG1193	negative regulation of DNA recombination
L6497_RS16790	COG2162	N-hydroxyarylamine O-acetyltransferase activity
L6497_RS16795	COG1164	Oligoendopeptidase f
L6497_RS16800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6497_RS16830	COG0584	glycerophosphoryl diester phosphodiesterase
L6497_RS16855	COG0640	Transcriptional regulator
L6497_RS16860	COG0604	alcohol dehydrogenase
L6497_RS16870	COG0457	Tetratricopeptide repeat
L6497_RS16880	COG2808	Putative FMN-binding domain
L6497_RS16885	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6497_RS16895	COG0385	Bile acid
L6497_RS16900	COG0277	FAD linked oxidase domain protein
L6497_RS16930	COG1216	Glycosyl transferase, family 2
L6497_RS16935	COG1024	Enoyl-CoA hydratase
L6497_RS16945	COG1285	pathogenesis
L6497_RS16960	COG2514	catechol 2,3-dioxygenase activity
L6497_RS16965	COG2720	vancomycin resistance protein
L6497_RS17005	COG0716	FMN binding
L6497_RS17055	COG0739	heme binding
L6497_RS17060	COG0741	lytic transglycosylase activity
L6497_RS17065	COG3409	Peptidoglycan-binding domain 1 protein
L6497_RS17065	COG3757	hydrolase, family 25
L6497_RS17115	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS17125	COG0165	Argininosuccinate lyase
L6497_RS17140	COG4145	pantothenate transmembrane transporter activity
L6497_RS17150	COG1012	belongs to the aldehyde dehydrogenase family
L6497_RS17155	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS17165	COG1657	PFAM Prenyltransferase squalene oxidase
L6497_RS17170	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
L6497_RS17175	COG2962	Rard protein
L6497_RS17180	COG3326	Membrane
L6497_RS17195	COG0489	protein tyrosine kinase activity
L6497_RS17205	COG0314	molybdopterin synthase activity
L6497_RS17210	COG0303	'Molybdopterin
L6497_RS17215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6497_RS17220	COG2116	formate transmembrane transporter activity
L6497_RS17230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6497_RS17235	COG5609	conserved protein (DUF2294)
L6497_RS17240	COG2427	Protein of unknown function (DUF1641)
L6497_RS17245	COG3383	formate dehydrogenase (NAD+) activity
L6497_RS17250	COG0697	spore germination
L6497_RS17290	COG2226	methyltransferase
L6497_RS17295	COG4166	transmembrane transport
L6497_RS17305	COG4166	transmembrane transport
L6497_RS17310	COG4166	transmembrane transport
L6497_RS17315	COG1301	dicarboxylic acid transport
L6497_RS17330	COG1595	DNA-templated transcription, initiation
L6497_RS17350	COG1131	(ABC) transporter
L6497_RS17375	COG0673	inositol 2-dehydrogenase activity
L6497_RS17385	COG0187	DNA topoisomerase II activity
L6497_RS17390	COG1832	CoA-binding protein
L6497_RS17395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6497_RS17400	COG0745	RESPONSE REGULATOR receiver
L6497_RS17420	COG4841	protein insertion into membrane
L6497_RS17425	COG0824	Thioesterase
L6497_RS17455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6497_RS17465	COG2274	protein secretion by the type I secretion system
L6497_RS17470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L6497_RS17510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6497_RS17525	COG0183	Belongs to the thiolase family
L6497_RS17530	COG0318	PFAM AMP-dependent synthetase and ligase
L6497_RS17535	COG1268	BioY protein
L6497_RS17540	COG0318	PFAM AMP-dependent synthetase and ligase
L6497_RS17550	COG1396	sequence-specific DNA binding
L6497_RS17600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6497_RS17610	COG5002	protein histidine kinase activity
L6497_RS17615	COG0400	carboxylic ester hydrolase activity
L6497_RS17620	COG0346	lactoylglutathione lyase activity
L6497_RS17625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6497_RS17630	COG0069	glutamate synthase activity
L6497_RS17635	COG1902	pentaerythritol trinitrate reductase activity
L6497_RS17640	COG1329	Transcriptional regulator
L6497_RS17645	COG0010	Belongs to the arginase family
L6497_RS17670	COG2226	methyltransferase
L6497_RS17710	COG3344	reverse transcriptase
L6497_RS17720	COG4846	Membrane protein involved in cytochrome C biogenesis
L6497_RS17725	COG0785	Cytochrome C biogenesis protein
L6497_RS17735	COG1473	amidohydrolase
L6497_RS17745	COG1131	(ABC) transporter
L6497_RS17755	COG0583	DNA-binding transcription factor activity
L6497_RS17765	COG1346	cytolysis
L6497_RS17780	COG0730	response to heat
L6497_RS17790	COG3409	Peptidoglycan-binding domain 1 protein
L6497_RS17790	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6497_RS17805	COG1132	(ABC) transporter
L6497_RS17810	COG1132	(ABC) transporter
L6497_RS17835	COG3639	organic phosphonate transmembrane transporter activity
L6497_RS17850	COG0737	Belongs to the 5'-nucleotidase family
L6497_RS17860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6497_RS17880	COG1695	Transcriptional regulator
L6497_RS17885	COG0174	glutamine synthetase
L6497_RS17890	COG0789	Transcriptional regulator
L6497_RS17895	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
L6497_RS17900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L6497_RS17905	COG2860	membrane
L6497_RS17910	COG0464	growth
L6497_RS17940	COG3584	3D domain protein
L6497_RS17940	COG1388	LysM domain
L6497_RS17945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6497_RS17945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6497_RS17945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6497_RS17950	COG1105	Belongs to the carbohydrate kinase PfkB family
L6497_RS17955	COG1349	DNA-binding transcription factor activity
L6497_RS17960	COG1979	alcohol dehydrogenase
L6497_RS17965	COG2322	membrane
L6497_RS17975	COG1113	amino acid transport
L6497_RS17990	COG1408	metallophosphoesterase
L6497_RS17995	COG2116	formate transmembrane transporter activity
L6497_RS18005	COG2217	Heavy metal translocating P-type atpase
L6497_RS18010	COG2608	mercury ion transmembrane transporter activity
L6497_RS18015	COG1937	Protein conserved in bacteria
L6497_RS18020	COG1464	Belongs to the NlpA lipoprotein family
L6497_RS18030	COG2819	hydrolase of the alpha beta superfamily
L6497_RS18035	COG1120	ATPase activity
L6497_RS18040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6497_RS18045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6497_RS18050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6497_RS18055	COG0708	Exodeoxyribonuclease III
L6497_RS18060	COG2169	Transcriptional regulator
L6497_RS18065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6497_RS18070	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L6497_RS18080	COG2364	Membrane
L6497_RS18090	COG0489	protein tyrosine kinase activity
L6497_RS18105	COG3300	MHYT domain
L6497_RS18105	COG5001	Diguanylate cyclase
L6497_RS18165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6497_RS18190	COG1404	Belongs to the peptidase S8 family
L6497_RS18195	COG3773	Cell wall hydrolase
L6497_RS18205	COG1368	sulfuric ester hydrolase activity
L6497_RS18210	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6497_RS18220	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
L6497_RS18240	COG4550	Control of competence regulator ComK, YlbF/YmcA
L6497_RS18250	COG1013	pyruvate-flavodoxin oxidoreductase activity
L6497_RS18255	COG0674	pyruvate-flavodoxin oxidoreductase activity
L6497_RS18255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L6497_RS18265	COG2359	stage V sporulation protein S
L6497_RS18270	COG1692	metallophosphoesterase
L6497_RS18290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L6497_RS18295	COG1426	Protein conserved in bacteria
L6497_RS18310	COG0300	oxidoreductase activity
L6497_RS18315	COG0612	Peptidase, M16
L6497_RS18320	COG0612	Peptidase, M16
L6497_RS18325	COG1079	Belongs to the binding-protein-dependent transport system permease family
L6497_RS18330	COG4603	Belongs to the binding-protein-dependent transport system permease family
L6497_RS18335	COG3845	ABC transporter
L6497_RS18340	COG1744	ABC transporter substrate-binding protein PnrA-like
L6497_RS18345	COG2188	Transcriptional regulator
L6497_RS18350	COG1674	ftsk spoiiie
L6497_RS18360	COG0740	serine-type endopeptidase activity
L6497_RS18365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6497_RS18375	COG0527	aspartate kinase activity
L6497_RS18380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6497_RS18385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6497_RS18390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6497_RS18395	COG1873	PFAM PRC-barrel domain
L6497_RS18400	COG0612	Peptidase, M16
L6497_RS18405	COG0726	polysaccharide deacetylase
L6497_RS18420	COG0196	riboflavin kinase activity
L6497_RS18435	COG1550	Protein conserved in bacteria
L6497_RS18445	COG1358	cellular component organization or biogenesis
L6497_RS18450	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L6497_RS18455	COG0195	Participates in both transcription termination and antitermination
L6497_RS18490	COG0750	zinc metalloprotease
L6497_RS18500	COG4589	Belongs to the CDS family
L6497_RS18515	COG0528	UMP kinase activity
L6497_RS18545	COG4974	Belongs to the 'phage' integrase family
L6497_RS18555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6497_RS18560	COG0758	DNA mediated transformation
L6497_RS18565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L6497_RS18605	COG1837	Belongs to the UPF0109 family
L6497_RS18615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L6497_RS18625	COG0552	protein localization to endoplasmic reticulum
L6497_RS18630	COG1196	nuclear chromosome segregation
L6497_RS18640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6497_RS18645	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS18650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L6497_RS18665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L6497_RS18670	COG1461	Dihydroxyacetone kinase
L6497_RS18675	COG1302	Protein conserved in bacteria
L6497_RS18690	COG1564	THIamine pyrophosphokinase
L6497_RS18695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L6497_RS18700	COG1162	GTPase activity
L6497_RS18705	COG0515	serine threonine protein kinase
L6497_RS18705	COG2815	serine threonine protein kinase
L6497_RS18710	COG0631	protein serine/threonine phosphatase activity
L6497_RS18720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6497_RS18720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6497_RS18730	COG0242	peptide deformylase activity
L6497_RS18735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L6497_RS18740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6497_RS18760	COG1561	YicC-like family, N-terminal region
L6497_RS18765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L6497_RS18775	COG0006	proline dipeptidase activity
L6497_RS18795	COG3069	C4-dicarboxylate transmembrane transporter activity
L6497_RS18860	COG0564	pseudouridine synthase activity
L6497_RS18880	COG3599	regulation of cell shape
L6497_RS18885	COG2302	S4 RNA-binding domain
L6497_RS18890	COG0762	integral membrane protein
L6497_RS18900	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L6497_RS18905	COG1496	oxidoreductase activity
L6497_RS18910	COG1873	PFAM PRC-barrel domain
L6497_RS18915	COG1191	sigma factor activity
L6497_RS18920	COG1191	sigma factor activity
L6497_RS18930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L6497_RS18935	COG0849	cell division
L6497_RS18940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L6497_RS18945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L6497_RS18955	COG0772	Belongs to the SEDS family
L6497_RS18970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6497_RS18975	COG0768	penicillin binding
L6497_RS18980	COG0768	penicillin binding
L6497_RS18985	COG4839	cell division protein FtsL
L6497_RS19000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6497_RS19015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L6497_RS19020	COG1399	metal-binding, possibly nucleic acid-binding protein
L6497_RS19030	COG3480	Lon protease (S16) C-terminal proteolytic domain
L6497_RS19035	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6497_RS19040	COG3314	Sporulation integral membrane protein YlbJ
L6497_RS19050	COG0742	ribosomal rna small subunit methyltransferase
L6497_RS19065	COG3679	Belongs to the UPF0342 family
L6497_RS19070	COG0406	alpha-ribazole phosphatase activity
L6497_RS19085	COG2340	Cysteine-rich secretory protein family
L6497_RS19100	COG3336	cytochrome c oxidase
L6497_RS19135	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L6497_RS19140	COG0772	Belongs to the SEDS family
L6497_RS19150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L6497_RS19155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L6497_RS19165	COG4896	Protein conserved in bacteria
L6497_RS19180	COG1217	gtp-binding protein TYPA
L6497_RS19190	COG0483	inositol monophosphate 1-phosphatase activity
L6497_RS19210	COG1982	Orn Lys Arg decarboxylase major
L6497_RS19260	COG0022	dehydrogenase e1 component
L6497_RS19265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6497_RS19275	COG0242	peptide deformylase activity
L6497_RS19280	COG0561	phosphatase activity
L6497_RS19290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6497_RS19295	COG0569	domain protein
L6497_RS19315	COG0583	DNA-binding transcription factor activity
L6497_RS19320	COG0517	IMP dehydrogenase activity
L6497_RS19330	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
L6497_RS19340	COG4703	Protein of unknown function (DUF1797)
L6497_RS19360	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS19365	COG1408	metallophosphoesterase
L6497_RS19375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L6497_RS19410	COG2814	Major facilitator Superfamily
L6497_RS19430	COG3209	COG3209 Rhs family protein
L6497_RS19440	COG2205	protein histidine kinase activity
L6497_RS19450	COG0436	Aminotransferase
L6497_RS19455	COG1609	Transcriptional regulator
L6497_RS19460	COG3833	ABC-type maltose transport systems, permease component
L6497_RS19465	COG1175	transmembrane transport
L6497_RS19470	COG2182	Extracellular solute-binding protein
L6497_RS19480	COG0366	Alpha amylase catalytic
L6497_RS19485	COG3842	ATPase activity
L6497_RS19530	COG0183	Belongs to the thiolase family
L6497_RS19565	COG1695	Transcriptional regulator
L6497_RS19570	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS19590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L6497_RS19595	COG0436	Aminotransferase
L6497_RS19630	COG2084	Dehydrogenase
L6497_RS19640	COG0778	Nitroreductase
L6497_RS19665	COG1263	PTS System
L6497_RS19665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6497_RS19665	COG2190	(PTS) system
L6497_RS19670	COG3711	transcriptional antiterminator
L6497_RS19680	COG2188	Transcriptional regulator
L6497_RS19690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6497_RS19715	COG1547	Domain of unknown function (DUF309)
L6497_RS19720	COG0456	acetyltransferase
L6497_RS19730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L6497_RS19735	COG4086	secreted protein
L6497_RS19740	COG0561	phosphatase activity
L6497_RS19745	COG0697	spore germination
L6497_RS19760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6497_RS19785	COG0733	neurotransmitter:sodium symporter activity
L6497_RS19805	COG1686	Belongs to the peptidase S11 family
L6497_RS19810	COG1725	Transcriptional regulator
L6497_RS19815	COG1131	(ABC) transporter
L6497_RS19830	COG1846	Transcriptional regulator
L6497_RS19845	COG0598	Magnesium transport protein CorA
L6497_RS19870	COG4974	Belongs to the 'phage' integrase family
L6497_RS19880	COG0735	belongs to the Fur family
L6497_RS19885	COG1300	Membrane
L6497_RS19905	COG0667	Aldo Keto reductase
L6497_RS19910	COG0656	L-ascorbic acid biosynthetic process
L6497_RS19915	COG0456	acetyltransferase
L6497_RS19915	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6497_RS19925	COG0737	Belongs to the 5'-nucleotidase family
L6497_RS19925	COG1525	nuclease
L6497_RS19925	COG4085	toxin activity
L6497_RS19935	COG0596	Alpha beta hydrolase
L6497_RS19940	COG2056	Na+-H+ antiporter family
L6497_RS19945	COG1609	Transcriptional regulator
L6497_RS19950	COG0456	acetyltransferase
L6497_RS19955	COG1073	alpha beta
L6497_RS19970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6497_RS19970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6497_RS19975	COG0307	riboflavin synthase, alpha
L6497_RS20000	COG4106	trans-aconitate 2-methyltransferase activity
L6497_RS20005	COG1073	alpha beta
L6497_RS20005	COG2226	methyltransferase
L6497_RS20020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6497_RS20030	COG1757	Na H antiporter
L6497_RS20035	COG0737	Belongs to the 5'-nucleotidase family
L6497_RS20045	COG1522	sequence-specific DNA binding
L6497_RS20065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6497_RS20075	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L6497_RS20090	COG0300	oxidoreductase activity
L6497_RS20095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6497_RS20100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6497_RS20105	COG1760	l-serine dehydratase
L6497_RS20110	COG1760	l-serine dehydratase
L6497_RS20130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6497_RS20140	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6497_RS20145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6497_RS20160	COG1376	ErfK ybiS ycfS ynhG family protein
L6497_RS20165	COG4129	membrane
L6497_RS20170	COG1126	abc transporter atp-binding protein
L6497_RS20175	COG0765	amino acid transport
L6497_RS20180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6497_RS20195	COG2816	NAD+ diphosphatase activity
L6497_RS20200	COG0772	Belongs to the SEDS family
L6497_RS20205	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6497_RS20210	COG0022	dehydrogenase e1 component
L6497_RS20215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6497_RS20220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6497_RS20235	COG0280	phosphate acetyltransferase
L6497_RS20240	COG3290	protein histidine kinase activity
L6497_RS20240	COG3829	transcription factor binding
L6497_RS20250	COG0584	glycerophosphoryl diester phosphodiesterase
L6497_RS20255	COG3093	addiction module antidote protein HigA
L6497_RS20355	COG0745	RESPONSE REGULATOR receiver
L6497_RS20360	COG0750	zinc metalloprotease
L6497_RS20365	COG0497	DNA recombination
L6497_RS20375	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L6497_RS20385	COG0142	geranyltranstransferase activity
L6497_RS20410	COG1302	Protein conserved in bacteria
L6497_RS20415	COG0439	Biotin carboxylase
L6497_RS20420	COG0511	ligase activity, forming carbon-carbon bonds
L6497_RS20465	COG3854	ATPases associated with a variety of cellular activities
L6497_RS20490	COG0006	proline dipeptidase activity
L6497_RS20505	COG3872	metal-dependent enzyme
L6497_RS20515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6497_RS20530	COG1695	Transcriptional regulator
L6497_RS20545	COG0095	Lipoate-protein ligase
L6497_RS20550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6497_RS20555	COG1609	Transcriptional regulator
L6497_RS20565	COG2076	Multidrug Resistance protein
L6497_RS20570	COG2076	Multidrug Resistance protein
L6497_RS20605	COG1131	(ABC) transporter
L6497_RS20610	COG1725	Transcriptional regulator
L6497_RS20640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6497_RS20695	COG4970	Tfp pilus assembly protein FimT
L6497_RS20745	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L6497_RS20745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L6497_RS20780	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
L6497_RS20825	COG1459	type II secretion system
L6497_RS20830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6497_RS20880	COG0646	methionine synthase
L6497_RS20880	COG1410	methionine synthase
L6497_RS20885	COG0646	methionine synthase
L6497_RS20885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L6497_RS20890	COG0626	cystathionine gamma-synthase activity
L6497_RS20895	COG0626	cystathionine gamma-synthase activity
L6497_RS20915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6497_RS20925	COG1940	carbohydrate kinase activity
L6497_RS20930	COG4483	Protein conserved in bacteria
L6497_RS20935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L6497_RS20940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L6497_RS20945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L6497_RS20950	COG0704	Plays a role in the regulation of phosphate uptake
L6497_RS20960	COG0581	inorganic phosphate transmembrane transporter activity
L6497_RS20965	COG0573	inorganic phosphate transmembrane transporter activity
L6497_RS20970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6497_RS20975	COG0768	penicillin binding
L6497_RS20980	COG0477	Major facilitator Superfamily
L6497_RS20985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6497_RS21010	COG0735	belongs to the Fur family
L6497_RS21015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6497_RS21020	COG1121	(ABC) transporter
L6497_RS21025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6497_RS21055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6497_RS21060	COG2384	SAM-dependent methyltransferase
L6497_RS21065	COG2010	Cytochrome c
L6497_RS21070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L6497_RS21075	COG0358	DNA primase activity
L6497_RS21095	COG0517	IMP dehydrogenase activity
L6497_RS21110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L6497_RS21115	COG0295	cytidine deaminase activity
L6497_RS21120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L6497_RS21130	COG1480	7TM receptor with intracellular HD hydrolase
L6497_RS21135	COG1702	phosphate starvation-inducible protein PhoH
L6497_RS21150	COG1610	YqeY-like protein
L6497_RS21155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L6497_RS21160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6497_RS21165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L6497_RS21195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6497_RS21200	COG1733	regulation of RNA biosynthetic process
L6497_RS21225	COG1466	dna polymerase III delta subunit
L6497_RS21235	COG0658	competence protein
L6497_RS21235	COG2333	competence protein COMEC
L6497_RS21240	COG2131	deaminase
L6497_RS21245	COG1596	polysaccharide export
L6497_RS21245	COG1555	photosystem II stabilization
L6497_RS21250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6497_RS21255	COG2226	methyltransferase
L6497_RS21260	COG0799	negative regulation of ribosome biogenesis
L6497_RS21265	COG1713	HD superfamily hydrolase involved in NAD metabolism
L6497_RS21275	COG1534	Rna-binding protein
L6497_RS21285	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L6497_RS21290	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
L6497_RS21315	COG1595	DNA-templated transcription, initiation
L6497_RS21325	COG0778	Nitroreductase
L6497_RS21330	COG2357	RelA SpoT domain protein
L6497_RS21340	COG1785	Belongs to the alkaline phosphatase family
L6497_RS21350	COG2267	carboxylic ester hydrolase activity
L6497_RS21385	COG1404	Belongs to the peptidase S8 family
L6497_RS21390	COG3186	Phenylalanine-4-hydroxylase
L6497_RS21400	COG2514	catechol 2,3-dioxygenase activity
L6497_RS21405	COG2259	Doxx family
L6497_RS21445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6497_RS21455	COG1012	belongs to the aldehyde dehydrogenase family
L6497_RS21455	COG1454	alcohol dehydrogenase
L6497_RS21460	COG0626	cystathionine gamma-synthase activity
L6497_RS21465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6497_RS21490	COG0768	penicillin binding
L6497_RS21505	COG0826	peptidase U32
L6497_RS21510	COG0826	peptidase U32
L6497_RS21515	COG4122	O-methyltransferase activity
L6497_RS21520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L6497_RS21550	COG0628	permease
L6497_RS21570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6497_RS21585	COG1104	cysteine desulfurase activity
L6497_RS21590	COG1959	2 iron, 2 sulfur cluster binding
L6497_RS21595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L6497_RS21605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L6497_RS21630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6497_RS21640	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L6497_RS21640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L6497_RS21645	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6497_RS21650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6497_RS21650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6497_RS21660	COG2244	polysaccharide biosynthetic process
L6497_RS21665	COG2323	membrane
L6497_RS21675	COG1862	Preprotein translocase
L6497_RS21705	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L6497_RS21715	COG0697	spore germination
L6497_RS21720	COG0640	Transcriptional regulator
L6497_RS21745	COG0157	Belongs to the NadC ModD family
L6497_RS21750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L6497_RS21755	COG1104	cysteine desulfurase activity
L6497_RS21760	COG1827	regulation of RNA biosynthetic process
L6497_RS21765	COG2258	MOSC domain
L6497_RS21770	COG0077	Prephenate dehydratase
L6497_RS21775	COG0577	efflux transmembrane transporter activity
L6497_RS21780	COG0577	efflux transmembrane transporter activity
L6497_RS21785	COG1136	(ABC) transporter
L6497_RS21790	COG5002	protein histidine kinase activity
L6497_RS21795	COG0745	RESPONSE REGULATOR receiver
L6497_RS21805	COG3290	protein histidine kinase activity
L6497_RS21815	COG2868	ribosomal protein
L6497_RS21825	COG1530	ribonuclease E activity
L6497_RS21830	COG1994	Peptidase M50
L6497_RS21835	COG0739	heme binding
L6497_RS21840	COG2894	cell division
L6497_RS21860	COG1077	Cell shape determining protein MreB Mrl
L6497_RS21880	COG0285	dihydrofolate synthase activity
L6497_RS21895	COG1388	LysM domain
L6497_RS21905	COG0113	porphobilinogen synthase activity
L6497_RS21910	COG1587	Uroporphyrinogen-III synthase
L6497_RS21920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6497_RS21930	COG1846	Transcriptional regulator
L6497_RS21935	COG1764	response to oxidative stress
L6497_RS21950	COG1067	ATP-dependent peptidase activity
L6497_RS21950	COG0470	DNA polymerase III
L6497_RS22000	COG0622	Phosphoesterase
L6497_RS22015	COG5401	PFAM Sporulation and spore germination
L6497_RS22035	COG1309	transcriptional regulator
L6497_RS22050	COG2197	response regulator
L6497_RS22055	COG2233	PERMEase
L6497_RS22065	COG0402	S-adenosylhomocysteine deaminase activity
L6497_RS22070	COG0402	S-adenosylhomocysteine deaminase activity
L6497_RS22080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6497_RS22090	COG0444	Belongs to the ABC transporter superfamily
L6497_RS22095	COG4608	Belongs to the ABC transporter superfamily
L6497_RS22100	COG3275	phosphorelay sensor kinase activity
L6497_RS22105	COG3279	Response regulator of the LytR AlgR family
L6497_RS22115	COG1983	PspC domain protein
L6497_RS22120	COG1396	sequence-specific DNA binding
L6497_RS22125	COG0697	spore germination
L6497_RS22135	COG1959	2 iron, 2 sulfur cluster binding
L6497_RS22140	COG1668	transmembrane transport
L6497_RS22145	COG4152	abc transporter atp-binding protein
L6497_RS22150	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L6497_RS22155	COG1360	Flagellar Motor Protein
L6497_RS22160	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6497_RS22165	COG1876	peptidase activity
L6497_RS22170	COG0824	Thioesterase
L6497_RS22175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L6497_RS22180	COG1053	succinate dehydrogenase
L6497_RS22185	COG2009	succinate dehydrogenase
L6497_RS22190	COG1719	4-vinyl reductase, 4VR
L6497_RS22200	COG3118	belongs to the thioredoxin family
L6497_RS22205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L6497_RS22210	COG2086	electron transfer activity
L6497_RS22215	COG1024	Enoyl-CoA hydratase
L6497_RS22220	COG1309	transcriptional regulator
L6497_RS22225	COG0318	PFAM AMP-dependent synthetase and ligase
L6497_RS22245	COG2318	DinB family
L6497_RS22270	COG1131	(ABC) transporter
L6497_RS22275	COG2205	protein histidine kinase activity
L6497_RS22280	COG0745	RESPONSE REGULATOR receiver
L6497_RS22290	COG4895	conserved protein (DUF2196)
L6497_RS22295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L6497_RS22310	COG4509	Sortase family
L6497_RS22315	COG1120	ATPase activity
L6497_RS22330	COG5386	Cell surface protein
L6497_RS22335	COG5386	Cell surface protein
L6497_RS22340	COG1114	Component of the transport system for branched-chain amino acids
L6497_RS22345	COG1187	pseudouridine synthase activity
L6497_RS22355	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6497_RS22355	COG1796	DNA polymerase
L6497_RS22360	COG1286	toxin biosynthetic process
L6497_RS22405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6497_RS22415	COG1418	mRNA catabolic process
L6497_RS22450	COG2814	Major facilitator Superfamily
L6497_RS22455	COG1566	PFAM secretion protein HlyD family protein
L6497_RS22460	COG1309	transcriptional regulator
L6497_RS22465	COG1363	Peptidase, m42
L6497_RS22490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6497_RS22500	COG1484	DNA-dependent DNA replication
L6497_RS22505	COG3611	Membrane attachment protein
L6497_RS22515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L6497_RS22520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6497_RS22525	COG0237	dephospho-CoA kinase activity
L6497_RS22530	COG1971	Probably functions as a manganese efflux pump
L6497_RS22540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6497_RS22540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6497_RS22545	COG5002	protein histidine kinase activity
L6497_RS22550	COG0745	RESPONSE REGULATOR receiver
L6497_RS22570	COG0538	isocitrate dehydrogenase activity
L6497_RS22575	COG0372	Belongs to the citrate synthase family
L6497_RS22585	COG0628	permease
L6497_RS22590	COG3030	protein affecting phage T7 exclusion by the F plasmid
L6497_RS22615	COG1725	Transcriptional regulator
L6497_RS22620	COG0281	malic enzyme
L6497_RS22625	COG0587	DNA-directed DNA polymerase activity
L6497_RS22640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L6497_RS22660	COG4109	DRTGG domain
L6497_RS22675	COG0006	proline dipeptidase activity
L6497_RS22715	COG0662	Cupin 2, conserved barrel domain protein
L6497_RS22730	COG1028	Short-chain dehydrogenase reductase Sdr
L6497_RS22735	COG0589	response to stress
L6497_RS22775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6497_RS22790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L6497_RS22795	COG0827	DNA restriction-modification system
L6497_RS22800	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L6497_RS22805	COG3874	Sporulation protein YtfJ
L6497_RS22820	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L6497_RS22830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6497_RS22845	COG1104	cysteine desulfurase activity
L6497_RS22855	COG0583	DNA-binding transcription factor activity
L6497_RS22860	COG0697	spore germination
L6497_RS22865	COG1309	transcriptional regulator
L6497_RS22870	COG1956	GAF domain-containing protein
L6497_RS22875	COG0626	cystathionine gamma-synthase activity
L6497_RS22905	COG1595	DNA-templated transcription, initiation
L6497_RS22915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6497_RS22920	COG0454	-acetyltransferase
L6497_RS22925	COG0517	IMP dehydrogenase activity
L6497_RS22930	COG0123	including yeast histone deacetylase and acetoin utilization protein
L6497_RS22945	COG0745	RESPONSE REGULATOR receiver
L6497_RS22950	COG5002	protein histidine kinase activity
L6497_RS22955	COG0666	response to abiotic stimulus
L6497_RS22990	COG1609	Transcriptional regulator
L6497_RS22995	COG4851	CamS sex pheromone cAM373 precursor
L6497_RS23000	COG3118	belongs to the thioredoxin family
L6497_RS23010	COG2309	aminopeptidase activity
L6497_RS23030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6497_RS23035	COG1695	Transcriptional regulator
L6497_RS23055	COG1674	ftsk spoiiie
L6497_RS23070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6497_RS23080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6497_RS23085	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
L6497_RS23090	COG1363	Peptidase, m42
L6497_RS23100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6497_RS23115	COG0510	thiamine kinase activity
L6497_RS23120	COG1523	belongs to the glycosyl hydrolase 13 family
L6497_RS23130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6497_RS23135	COG1349	DNA-binding transcription factor activity
L6497_RS23140	COG1187	pseudouridine synthase activity
L6497_RS23145	COG2244	polysaccharide biosynthetic process
L6497_RS23150	COG2081	HI0933 family
L6497_RS23155	COG2814	Major facilitator Superfamily
L6497_RS23165	COG3832	glyoxalase III activity
L6497_RS23185	COG1329	Transcriptional regulator
L6497_RS23210	COG0314	molybdopterin synthase activity
L6497_RS23215	COG1763	Mo-molybdopterin cofactor biosynthetic process
L6497_RS23220	COG0303	'Molybdopterin
L6497_RS23230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6497_RS23235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L6497_RS23255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6497_RS23265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L6497_RS23310	COG2814	Major facilitator Superfamily
L6497_RS23315	COG0475	glutathione-regulated potassium exporter activity
L6497_RS23320	COG0490	domain, Protein
L6497_RS23325	COG0582	viral genome integration into host DNA
L6497_RS23335	COG1136	(ABC) transporter
L6497_RS23355	COG1242	4 iron, 4 sulfur cluster binding
L6497_RS23360	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L6497_RS23375	COG1794	racemase activity, acting on amino acids and derivatives
L6497_RS23385	COG5504	Zn-dependent protease
L6497_RS23410	COG2267	carboxylic ester hydrolase activity
L6497_RS23415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L6497_RS23420	COG0671	phosphoesterase, PA-phosphatase related
L6497_RS23425	COG0438	transferase activity, transferring glycosyl groups
L6497_RS23435	COG0521	Mo-molybdopterin cofactor biosynthetic process
L6497_RS23495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6497_RS23500	COG5002	protein histidine kinase activity
L6497_RS23505	COG4191	Histidine kinase
L6497_RS23510	COG2267	carboxylic ester hydrolase activity
L6497_RS23515	COG1368	sulfuric ester hydrolase activity
L6497_RS23530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6497_RS23535	COG1116	anion transmembrane transporter activity
L6497_RS23540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6497_RS23555	COG0546	phosphoglycolate phosphatase activity
L6497_RS23565	COG0494	nUDIX hydrolase
L6497_RS23600	COG0288	reversible hydration of carbon dioxide
L6497_RS23605	COG1271	oxidase subunit
L6497_RS23610	COG1294	oxidase, subunit
L6497_RS23630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6497_RS23655	COG1842	Phage shock protein A
L6497_RS23690	COG3859	Proton-coupled thiamine transporter YuaJ
L6497_RS23700	COG0745	RESPONSE REGULATOR receiver
L6497_RS23725	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L6497_RS23730	COG1597	lipid kinase activity
L6497_RS23750	COG0577	efflux transmembrane transporter activity
L6497_RS23755	COG1136	(ABC) transporter
L6497_RS23785	COG0586	Pfam SNARE associated Golgi protein
L6497_RS23795	COG4977	sequence-specific DNA binding
L6497_RS23805	COG0577	efflux transmembrane transporter activity
L6497_RS23810	COG1136	(ABC) transporter
L6497_RS23815	COG3708	Transcriptional regulator
L6497_RS23815	COG2207	Transcriptional regulator
L6497_RS23825	COG1595	DNA-templated transcription, initiation
L6497_RS23830	COG0745	RESPONSE REGULATOR receiver
L6497_RS23835	COG2205	protein histidine kinase activity
L6497_RS23840	COG0577	efflux transmembrane transporter activity
L6497_RS23845	COG0577	efflux transmembrane transporter activity
L6497_RS23850	COG1136	(ABC) transporter
L6497_RS23855	COG0577	efflux transmembrane transporter activity
L6497_RS23870	COG2188	Transcriptional regulator
L6497_RS23890	COG3964	amidohydrolase
L6497_RS23910	COG4948	Mandelate Racemase Muconate Lactonizing
L6497_RS23920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L6497_RS23925	COG0596	Alpha beta hydrolase
L6497_RS23935	COG1169	isochorismate synthase
L6497_RS23940	COG1575	Belongs to the MenA family. Type 1 subfamily
L6497_RS23945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L6497_RS23965	COG0058	SHG alpha-glucan phosphorylase activity
L6497_RS23975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L6497_RS23995	COG1404	Belongs to the peptidase S8 family
L6497_RS24095	COG0544	peptidyl-prolyl cis-trans isomerase activity
L6497_RS24130	COG1285	pathogenesis
L6497_RS24135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6497_RS24150	COG2155	Conserved Protein
L6497_RS24155	COG1098	S1 RNA binding domain
L6497_RS24160	COG0436	Aminotransferase
L6497_RS24165	COG1522	sequence-specific DNA binding
L6497_RS24170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6497_RS24175	COG2267	carboxylic ester hydrolase activity
L6497_RS24185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L6497_RS24205	COG5018	Exonuclease
L6497_RS24210	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6497_RS24230	COG2050	protein possibly involved in aromatic compounds catabolism
L6497_RS24240	COG1268	BioY protein
L6497_RS24245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L6497_RS24250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L6497_RS24265	COG3584	3D domain protein
L6497_RS24280	COG1252	NADH dehydrogenase
L6497_RS24295	COG3344	reverse transcriptase
L6497_RS24305	COG3708	Transcriptional regulator
L6497_RS24320	COG1683	Conserved Protein
L6497_RS24330	COG0316	Belongs to the HesB IscA family
L6497_RS24345	COG1252	NADH dehydrogenase
L6497_RS24355	COG2274	protein secretion by the type I secretion system
L6497_RS24360	COG0390	transport system, permease component
L6497_RS24365	COG2824	Alkylphosphonate utilization operon protein PhnA
L6497_RS24385	COG4837	Protein of unknown function (DUF1462)
L6497_RS24390	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L6497_RS24400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6497_RS24405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L6497_RS24420	COG0577	efflux transmembrane transporter activity
L6497_RS24420	COG1136	(ABC) transporter
L6497_RS24425	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6497_RS24430	COG0647	UMP catabolic process
L6497_RS24440	COG2445	Protein of unknown function DUF86
L6497_RS24445	COG1494	fructose-1,6-bisphosphatase
L6497_RS24460	COG4470	Protein conserved in bacteria
L6497_RS24470	COG0789	Transcriptional regulator
L6497_RS24475	COG4377	Putative membrane peptidase family (DUF2324)
L6497_RS24500	COG0739	heme binding
L6497_RS24510	COG3377	Domain of unknown function (DUF1805)
L6497_RS24515	COG0737	Belongs to the 5'-nucleotidase family
L6497_RS24520	COG1695	Transcriptional regulator
L6497_RS24530	COG0719	Fe-S assembly protein
L6497_RS24535	COG0822	iron-sulfur transferase activity
L6497_RS24540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L6497_RS24545	COG0719	Fe-S assembly protein
L6497_RS24550	COG0396	ATPase activity
L6497_RS24555	COG1464	Belongs to the NlpA lipoprotein family
L6497_RS24560	COG1464	Belongs to the NlpA lipoprotein family
L6497_RS24565	COG2011	ABC-type metal ion transport system permease component
L6497_RS24580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6497_RS24585	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6497_RS24595	COG1393	Belongs to the ArsC family
L6497_RS24640	COG0039	L-malate dehydrogenase activity
L6497_RS24665	COG1309	transcriptional regulator
L6497_RS24670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6497_RS24680	COG4555	ABC transporter
L6497_RS24715	COG1960	acyl-CoA dehydrogenase activity
L6497_RS24720	COG0183	Belongs to the thiolase family
L6497_RS24725	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6497_RS24725	COG1024	Enoyl-CoA hydratase
L6497_RS24735	COG1686	Belongs to the peptidase S11 family
L6497_RS24750	COG0011	TIGRFAM Protein of
L6497_RS24755	COG0840	transmembrane signaling receptor activity
L6497_RS24775	COG2814	Major facilitator Superfamily
L6497_RS24780	COG0531	amino acid
L6497_RS24795	COG0706	membrane insertase activity
L6497_RS24805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6497_RS24840	COG0586	Pfam SNARE associated Golgi protein
L6497_RS24850	COG1376	ErfK ybiS ycfS ynhG family protein
L6497_RS24855	COG0745	RESPONSE REGULATOR receiver
L6497_RS24860	COG5002	protein histidine kinase activity
L6497_RS24885	COG0840	transmembrane signaling receptor activity
L6497_RS24890	COG2151	metal-sulfur cluster biosynthetic enzyme
L6497_RS24895	COG3227	Zinc metalloprotease (Elastase)
L6497_RS24900	COG1741	Belongs to the pirin family
L6497_RS24915	COG0475	glutathione-regulated potassium exporter activity
L6497_RS24920	COG0490	domain, Protein
L6497_RS24925	COG1115	amino acid carrier protein
L6497_RS24935	COG0783	Belongs to the Dps family
L6497_RS24950	COG1611	Belongs to the LOG family
L6497_RS24970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6497_RS24975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6497_RS24980	COG1115	amino acid carrier protein
L6497_RS24985	COG1115	amino acid carrier protein
L6497_RS24990	COG2910	NAD(P)H-binding
L6497_RS25005	COG0656	L-ascorbic acid biosynthetic process
L6497_RS25010	COG2814	Major facilitator Superfamily
L6497_RS25015	COG1733	regulation of RNA biosynthetic process
L6497_RS25025	COG1252	NADH dehydrogenase
L6497_RS25030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L6497_RS25045	COG3290	protein histidine kinase activity
L6497_RS25045	COG0840	transmembrane signaling receptor activity
L6497_RS25055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6497_RS25080	COG0488	(ABC) transporter
L6497_RS25085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6497_RS25095	COG2814	Major facilitator Superfamily
L6497_RS25150	COG0557	exoribonuclease II activity
L6497_RS25155	COG1647	Serine aminopeptidase, S33
L6497_RS25160	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6497_RS25165	COG1346	cytolysis
L6497_RS25220	COG4974	Belongs to the 'phage' integrase family
L6497_RS25245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6497_RS25260	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L6497_RS25285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6497_RS25300	COG2323	membrane
L6497_RS25310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6497_RS25320	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L6497_RS25330	COG1051	belongs to the nudix hydrolase family
L6497_RS25340	COG0492	ferredoxin-NADP+ reductase activity
L6497_RS25345	COG0457	Tetratricopeptide repeat
L6497_RS25350	COG0110	maltose O-acetyltransferase activity
L6497_RS25370	COG1950	PFAM Membrane protein of
L6497_RS25380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6497_RS25385	COG0556	nucleotide-excision repair
L6497_RS25400	COG0789	Transcriptional regulator
L6497_RS25425	COG2855	membrane
L6497_RS25430	COG0583	DNA-binding transcription factor activity
L6497_RS25440	COG0655	NAD(P)H dehydrogenase (quinone) activity
L6497_RS25445	COG0488	(ABC) transporter
L6497_RS25455	COG1132	(ABC) transporter
L6497_RS25460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6497_RS25465	COG3409	Peptidoglycan-binding domain 1 protein
L6497_RS25465	COG0793	Belongs to the peptidase S41A family
L6497_RS25470	COG2177	Part of the ABC transporter FtsEX involved in
L6497_RS25475	COG2884	Cell division ATP-binding protein ftsE
L6497_RS25495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L6497_RS25500	COG1278	Cold shock
L6497_RS25505	COG1040	competence protein
L6497_RS25510	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L6497_RS25515	COG0791	NLP P60 protein
L6497_RS25515	COG1388	LysM domain
L6497_RS25520	COG1733	regulation of RNA biosynthetic process
L6497_RS25525	COG1307	EDD domain protein, DegV family
L6497_RS25530	COG1739	Uncharacterized protein family UPF0029
L6497_RS25535	COG1316	TRANSCRIPTIONal
L6497_RS25540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L6497_RS25545	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L6497_RS25550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L6497_RS25560	COG3933	PFAM sigma-54 factor interaction domain-containing protein
L6497_RS25560	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L6497_RS25580	COG1486	melibiose metabolic process
L6497_RS25585	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6497_RS25590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6497_RS25600	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L6497_RS25620	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6497_RS25630	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6497_RS25635	COG1301	dicarboxylic acid transport
L6497_RS25645	COG0346	lactoylglutathione lyase activity
L6497_RS25665	COG1511	domain protein
L6497_RS25670	COG0583	DNA-binding transcription factor activity
L6497_RS25675	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
L6497_RS25685	COG1271	oxidase subunit
L6497_RS25690	COG1294	oxidase, subunit
L6497_RS25695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6497_RS25705	COG1620	l-lactate permease
L6497_RS25720	COG2389	metal-binding protein
L6497_RS25730	COG1368	sulfuric ester hydrolase activity
L6497_RS25740	COG0791	NLP P60 protein
L6497_RS25740	COG1388	LysM domain
L6497_RS25745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6497_RS25755	COG1215	transferase activity, transferring glycosyl groups
L6497_RS25760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6497_RS25765	COG1388	LysM domain
L6497_RS25765	COG3584	3D domain protein
L6497_RS25790	COG4715	Zinc finger, swim domain protein
L6497_RS25795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6497_RS25840	COG0577	efflux transmembrane transporter activity
L6497_RS25845	COG1136	(ABC) transporter
L6497_RS25885	COG0745	RESPONSE REGULATOR receiver
L6497_RS25890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6497_RS25910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L6497_RS25915	COG1134	teichoic acid transport
L6497_RS25920	COG1682	transport, permease protein
L6497_RS25940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L6497_RS25945	COG1442	glycosyl transferase family 8
L6497_RS25945	COG1216	Glycosyl transferase, family 2
L6497_RS25950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L6497_RS25955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L6497_RS25965	COG1609	Transcriptional regulator
L6497_RS25975	COG0739	heme binding
L6497_RS25990	COG3279	Response regulator of the LytR AlgR family
L6497_RS25995	COG2385	sporulation resulting in formation of a cellular spore
L6497_RS26010	COG4836	Membrane
L6497_RS26015	COG1007	ATP synthesis coupled electron transport
L6497_RS26020	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6497_RS26025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6497_RS26035	COG0839	Belongs to the complex I subunit 6 family
L6497_RS26055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6497_RS26120	COG0356	it plays a direct role in the translocation of protons across the membrane
L6497_RS26155	COG0698	ribose 5-phosphate isomerase
L6497_RS26165	COG2190	(PTS) system
L6497_RS26170	COG2259	Doxx family
L6497_RS26175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L6497_RS26190	COG0009	L-threonylcarbamoyladenylate synthase
L6497_RS26205	COG2890	protein-(glutamine-N5) methyltransferase activity
L6497_RS26225	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L6497_RS26230	COG1494	fructose-1,6-bisphosphatase
L6497_RS26250	COG4821	SIS domain
L6497_RS26270	COG1960	acyl-CoA dehydrogenase activity
L6497_RS26275	COG1960	acyl-CoA dehydrogenase activity
L6497_RS26280	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6497_RS26285	COG0183	Belongs to the thiolase family
L6497_RS26290	COG0247	lactate metabolic process
L6497_RS26290	COG2181	nitrate reductase activity
L6497_RS26295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6497_RS26305	COG3300	MHYT domain
L6497_RS26305	COG5001	Diguanylate cyclase
L6497_RS26325	COG2197	response regulator
L6497_RS26330	COG4585	Histidine kinase
L6497_RS26335	COG0842	Transport permease protein
L6497_RS26340	COG1131	(ABC) transporter
L6497_RS26345	COG0024	Methionine aminopeptidase
L6497_RS26355	COG2234	aminopeptidase activity
L6497_RS26375	COG1595	DNA-templated transcription, initiation
L6497_RS26385	COG4506	Protein conserved in bacteria
L6497_RS26390	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6497_RS26405	COG0010	Belongs to the arginase family
L6497_RS26415	COG2814	Major facilitator Superfamily
L6497_RS26420	COG0789	Transcriptional regulator
L6497_RS26425	COG0584	glycerophosphoryl diester phosphodiesterase
L6497_RS26430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6497_RS26440	COG1994	Peptidase M50
L6497_RS26450	COG1078	dGTPase activity
L6497_RS26455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6497_RS26460	COG1120	ATPase activity
L6497_RS26465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6497_RS26470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6497_RS26490	COG0095	Lipoate-protein ligase
L6497_RS26495	COG0280	phosphate acetyltransferase
L6497_RS26510	COG3773	Cell wall hydrolase
L6497_RS26520	COG2363	Small membrane protein
L6497_RS26530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6497_RS26535	COG2233	PERMEase
L6497_RS26540	COG0561	phosphatase activity
L6497_RS26545	COG2814	Major facilitator Superfamily
L6497_RS26555	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6497_RS26560	COG1131	(ABC) transporter
L6497_RS26565	COG2755	lipolytic protein G-D-S-L family
L6497_RS26570	COG1609	Transcriptional regulator
L6497_RS26580	COG0460	homoserine dehydrogenase
L6497_RS26590	COG2873	o-acetylhomoserine
L6497_RS26600	COG1011	Hydrolase
L6497_RS26615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6497_RS26625	COG2197	response regulator
L6497_RS26630	COG4585	Histidine kinase
L6497_RS26630	COG2203	Gaf domain
L6497_RS26635	COG0351	phosphomethylpyrimidine kinase
L6497_RS26640	COG3706	GGDEF domain
L6497_RS26645	COG2879	small protein
L6497_RS26650	COG1966	Carbon starvation protein
L6497_RS26655	COG3279	Response regulator of the LytR AlgR family
L6497_RS26660	COG0477	Major facilitator Superfamily
L6497_RS26685	COG0840	transmembrane signaling receptor activity
L6497_RS26695	COG1607	acyl-coa hydrolase
L6497_RS26710	COG0488	(ABC) transporter
L6497_RS26730	COG0463	Glycosyl transferase, family 2
L6497_RS26735	COG1309	transcriptional regulator
L6497_RS26740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6497_RS26745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6497_RS26745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6497_RS26750	COG0628	permease
L6497_RS26760	COG1380	Effector of murein hydrolase LrgA
L6497_RS26765	COG3279	Response regulator of the LytR AlgR family
L6497_RS26770	COG3275	phosphorelay sensor kinase activity
L6497_RS26775	COG2814	Major facilitator Superfamily
L6497_RS26780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6497_RS26785	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
L6497_RS26790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6497_RS26810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6497_RS26815	COG1272	protein, Hemolysin III
L6497_RS26840	COG1164	Oligoendopeptidase f
L6497_RS26860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6497_RS26865	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L6497_RS26870	COG4853	Protein conserved in bacteria
L6497_RS26875	COG4863	YycH protein
L6497_RS26880	COG5002	protein histidine kinase activity
L6497_RS26885	COG0745	RESPONSE REGULATOR receiver
L6497_RS26915	COG0305	Participates in initiation and elongation during chromosome replication
L6497_RS26925	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
L6497_RS26930	COG4241	membrane
L6497_RS26940	COG0629	single-stranded DNA binding
L6497_RS26950	COG0012	GTP binding
L6497_RS26955	COG4481	Protein conserved in bacteria
L6497_RS26960	COG0668	transmembrane transport
L6497_RS26970	COG1475	DNA binding
L6497_RS26975	COG1192	Involved in chromosome partitioning
L6497_RS27000	COG1847	R3H domain protein
L6497_RS27005	COG0706	membrane insertase activity
L6497_RS27015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L6497_RS27075	COG0438	transferase activity, transferring glycosyl groups
L6497_RS27095	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6497_RS27140	COG1181	Belongs to the D-alanine--D-alanine ligase family
L6497_RS27140	COG2918	glutathione biosynthetic process
L6497_RS27150	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L6497_RS27160	COG1733	regulation of RNA biosynthetic process
L6497_RS27190	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
L6497_RS27205	COG3848	Pyruvate phosphate dikinase
L6497_RS27205	COG0574	Belongs to the PEP-utilizing enzyme family
L6497_RS27210	COG1819	glycosyl
L6497_RS27215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6497_RS27235	COG1063	alcohol dehydrogenase
L6497_RS27265	COG0697	spore germination
L6497_RS27290	COG2323	membrane
L6497_RS27305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6497_RS27345	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6497_RS27360	COG3708	Transcriptional regulator
L6497_RS27360	COG2207	Transcriptional regulator
L6497_RS27415	COG0789	Transcriptional regulator
L6497_RS27490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L6497_RS27525	COG2002	toxin-antitoxin pair type II binding
L6497_RS27560	COG0776	regulation of translation
L6497_RS27590	COG2311	Membrane
L6497_RS27620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6497_RS27625	COG1621	beta-fructofuranosidase activity
L6497_RS27630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6497_RS27630	COG1263	PTS System
L6497_RS27635	COG1609	Transcriptional regulator
L6497_RS28100	COG3344	reverse transcriptase
L6497_RS28120	COG0583	DNA-binding transcription factor activity
L6497_RS28125	COG2814	Major facilitator Superfamily
L6497_RS28170	COG0305	Participates in initiation and elongation during chromosome replication
L6497_RS28180	COG3546	catalase activity
L6497_RS28190	COG4372	Transposase
L6497_RS28230	COG0546	phosphoglycolate phosphatase activity
L6497_RS28245	COG0167	dihydroorotate dehydrogenase activity
L6497_RS28250	COG3238	Protein conserved in bacteria
L6497_RS28255	COG1611	Belongs to the LOG family
L6497_RS28260	COG1475	DNA binding
L6497_RS28265	COG2368	4-hydroxyphenylacetate
L6497_RS28270	COG0494	nUDIX hydrolase
L6497_RS28285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L6497_RS28355	COG1073	alpha beta
L6497_RS28365	COG3103	Sh3 type 3 domain protein
L6497_RS28365	COG1388	LysM domain
L6497_RS28365	COG0791	NLP P60 protein
L6497_RS28405	COG3397	chitin binding
L6497_RS28470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L6497_RS28485	COG2003	Belongs to the UPF0758 family
L6497_RS28515	COG0582	viral genome integration into host DNA
L6497_RS28520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6497_RS28555	COG1396	sequence-specific DNA binding
L6497_RS28620	COG3344	reverse transcriptase
L6497_RS28640	COG3344	reverse transcriptase
L6497_RS28650	COG3344	reverse transcriptase
L6497_RS28695	COG0758	DNA mediated transformation
L6497_RS28745	COG0457	Tetratricopeptide repeat
L6497_RS28760	COG4974	Belongs to the 'phage' integrase family
L6497_RS28795	COG0745	RESPONSE REGULATOR receiver
L6497_RS28800	COG4990	cell redox homeostasis
L6497_RS28805	COG1335	isochorismatase
L6497_RS28865	COG1674	ftsk spoiiie
L6497_RS28990	COG3012	SEC-C Motif Domain Protein
L6497_RS28990	COG1405	negative regulation of cell septum assembly
L6497_RS29005	COG2003	Belongs to the UPF0758 family
L6497_RS29035	COG3344	reverse transcriptase
L6497_RS29050	COG3344	reverse transcriptase
L6497_RS29065	COG0582	viral genome integration into host DNA
L6497_RS29085	COG0741	lytic transglycosylase activity
L6497_RS29085	COG0791	NLP P60 protein
L6497_RS29105	COG3344	reverse transcriptase
L6497_RS29175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L6497_RS29225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L6497_RS29250	COG0681	Belongs to the peptidase S26 family
L6497_RS29310	COG4372	Transposase
L6497_RS29330	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L6497_RS29420	COG4824	toxin secretion phage lysis holin
L6497_RS29455	COG2801	Transposase and inactivated derivatives
L6497_RS29515	COG3708	Transcriptional regulator
L6497_RS29515	COG2207	Transcriptional regulator
L6497_RS29525	COG4974	Belongs to the 'phage' integrase family
L6497_RS29630	COG0457	Tetratricopeptide repeat
L6497_RS29745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L6497_RS29745	COG0758	DNA mediated transformation