locus-tag	class	description
E4A35_RS00010	COG0592	DNA-directed DNA polymerase activity
E4A35_RS00015	COG2501	S4 domain
E4A35_RS00025	COG0187	DNA topoisomerase II activity
E4A35_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4A35_RS00065	COG0517	IMP dehydrogenase activity
E4A35_RS00065	COG0516	GMP reductase activity
E4A35_RS00070	COG1686	Belongs to the peptidase S11 family
E4A35_RS00100	COG1428	Deoxynucleoside kinase
E4A35_RS00105	COG1428	Deoxynucleoside kinase
E4A35_RS00110	COG1335	isochorismatase
E4A35_RS00115	COG0590	tRNA wobble adenosine to inosine editing
E4A35_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4A35_RS00180	COG1982	Orn Lys Arg decarboxylase major
E4A35_RS00190	COG0470	DNA polymerase III
E4A35_RS00195	COG1774	PSP1 C-terminal conserved region
E4A35_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4A35_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4A35_RS00220	COG2002	toxin-antitoxin pair type II binding
E4A35_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4A35_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4A35_RS00230	COG0084	hydrolase, TatD family'
E4A35_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E4A35_RS00250	COG4466	Protein conserved in bacteria
E4A35_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4A35_RS00270	COG0251	oxidation-reduction process
E4A35_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4A35_RS00305	COG2002	toxin-antitoxin pair type II binding
E4A35_RS00310	COG2244	polysaccharide biosynthetic process
E4A35_RS00315	COG3956	TIGRFAM MazG family protein
E4A35_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4A35_RS00340	COG1098	S1 RNA binding domain
E4A35_RS00355	COG2208	phosphoserine phosphatase activity
E4A35_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4A35_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4A35_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4A35_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4A35_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
E4A35_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4A35_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4A35_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4A35_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4A35_RS00420	COG1396	sequence-specific DNA binding
E4A35_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4A35_RS00515	COG3880	PFAM UvrB UvrC protein
E4A35_RS00525	COG0542	response to heat
E4A35_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4A35_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
E4A35_RS00560	COG1045	serine acetyltransferase
E4A35_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4A35_RS00580	COG3688	RNA-binding protein containing a PIN domain
E4A35_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4A35_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
E4A35_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4A35_RS00625	COG2813	Specifically methylates the guanine in position
E4A35_RS00640	COG1358	cellular component organization or biogenesis
E4A35_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
E4A35_RS00770	COG0201	protein transport
E4A35_RS00780	COG0024	Methionine aminopeptidase
E4A35_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4A35_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E4A35_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4A35_RS00855	COG0489	protein tyrosine kinase activity
E4A35_RS00865	COG2194	sulfuric ester hydrolase activity
E4A35_RS00870	COG0726	polysaccharide deacetylase
E4A35_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4A35_RS00955	COG4856	YbbR-like protein
E4A35_RS00980	COG0596	Alpha beta hydrolase
E4A35_RS01000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4A35_RS01005	COG0823	Involved in the tonB-independent uptake of proteins
E4A35_RS01005	COG4946	Tricorn protease homolog
E4A35_RS01005	COG1506	peptidase
E4A35_RS01035	COG0604	alcohol dehydrogenase
E4A35_RS01045	COG0277	FAD linked oxidase domain protein
E4A35_RS01050	COG2271	Major facilitator Superfamily
E4A35_RS01060	COG2814	Major facilitator Superfamily
E4A35_RS01075	COG0601	transmembrane transport
E4A35_RS01080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4A35_RS01085	COG0444	Belongs to the ABC transporter superfamily
E4A35_RS01090	COG4608	Belongs to the ABC transporter superfamily
E4A35_RS01095	COG4166	transmembrane transport
E4A35_RS01105	COG2207	Transcriptional regulator
E4A35_RS01120	COG4166	transmembrane transport
E4A35_RS01125	COG4166	transmembrane transport
E4A35_RS01130	COG0656	L-ascorbic acid biosynthetic process
E4A35_RS01135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4A35_RS01150	COG4149	molybdate abc transporter
E4A35_RS01155	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4A35_RS01160	COG1910	domain protein
E4A35_RS01175	COG0697	spore germination
E4A35_RS01190	COG0204	Acyl-transferase
E4A35_RS01200	COG1609	Transcriptional regulator
E4A35_RS01210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4A35_RS01230	COG5298	Protein conserved in bacteria
E4A35_RS01250	COG0488	(ABC) transporter
E4A35_RS01255	COG4585	Histidine kinase
E4A35_RS01260	COG2197	response regulator
E4A35_RS01265	COG1131	(ABC) transporter
E4A35_RS01270	COG1511	domain protein
E4A35_RS01270	COG0842	Transport permease protein
E4A35_RS01275	COG0842	Transport permease protein
E4A35_RS01290	COG0747	negative chemotaxis
E4A35_RS01295	COG0601	transmembrane transport
E4A35_RS01300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4A35_RS01305	COG0444	Belongs to the ABC transporter superfamily
E4A35_RS01310	COG4608	Belongs to the ABC transporter superfamily
E4A35_RS01315	COG0561	phosphatase activity
E4A35_RS01345	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E4A35_RS01350	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4A35_RS01360	COG2814	Major facilitator Superfamily
E4A35_RS01370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4A35_RS01380	COG4294	response to UV
E4A35_RS01385	COG0705	Rhomboid family
E4A35_RS01385	COG0457	Tetratricopeptide repeat
E4A35_RS01395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4A35_RS01400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4A35_RS01405	COG0864	Transcriptional regulator
E4A35_RS01410	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4A35_RS01415	COG2183	response to ionizing radiation
E4A35_RS01510	COG0802	atpase or kinase
E4A35_RS01515	COG1214	PFAM Peptidase M22, glycoprotease
E4A35_RS01520	COG0456	acetyltransferase
E4A35_RS01530	COG0488	(ABC) transporter
E4A35_RS01545	COG1266	CAAX protease self-immunity
E4A35_RS01565	COG2252	PERMEase
E4A35_RS01575	COG5002	protein histidine kinase activity
E4A35_RS01600	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4A35_RS01630	COG2226	methyltransferase
E4A35_RS01640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4A35_RS01650	COG1215	transferase activity, transferring glycosyl groups
E4A35_RS01690	COG2205	protein histidine kinase activity
E4A35_RS01695	COG0745	RESPONSE REGULATOR receiver
E4A35_RS01715	COG0697	spore germination
E4A35_RS01745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4A35_RS01750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4A35_RS01755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4A35_RS01765	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4A35_RS01780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4A35_RS01790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4A35_RS01800	COG0151	Belongs to the GarS family
E4A35_RS01830	COG0210	DNA helicase
E4A35_RS01840	COG4851	CamS sex pheromone cAM373 precursor
E4A35_RS01855	COG1335	isochorismatase
E4A35_RS01870	COG2011	ABC-type metal ion transport system permease component
E4A35_RS01875	COG1464	Belongs to the NlpA lipoprotein family
E4A35_RS01890	COG0003	Pfam Anion-transporting ATPase
E4A35_RS01895	COG1846	Transcriptional regulator
E4A35_RS01900	COG4682	membrane
E4A35_RS01920	COG1597	lipid kinase activity
E4A35_RS01925	COG0546	phosphoglycolate phosphatase activity
E4A35_RS01930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4A35_RS01940	COG1012	belongs to the aldehyde dehydrogenase family
E4A35_RS01945	COG2076	Multidrug Resistance protein
E4A35_RS01950	COG2309	aminopeptidase activity
E4A35_RS01965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4A35_RS01970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4A35_RS01975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4A35_RS01980	COG5002	protein histidine kinase activity
E4A35_RS01985	COG4807	Protein conserved in bacteria
E4A35_RS02010	COG1757	Na H antiporter
E4A35_RS02015	COG1473	amidohydrolase
E4A35_RS02030	COG0450	alkyl hydroperoxide reductase
E4A35_RS02050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4A35_RS02055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4A35_RS02060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4A35_RS02085	COG0166	Belongs to the GPI family
E4A35_RS02135	COG3541	Predicted nucleotidyltransferase
E4A35_RS02145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4A35_RS02145	COG0723	plastoquinol--plastocyanin reductase activity
E4A35_RS02155	COG0765	amino acid transport
E4A35_RS02160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4A35_RS02175	COG0840	transmembrane signaling receptor activity
E4A35_RS02180	COG0840	transmembrane signaling receptor activity
E4A35_RS02225	COG0366	Alpha amylase catalytic
E4A35_RS02230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4A35_RS02230	COG1263	PTS System
E4A35_RS02230	COG2190	(PTS) system
E4A35_RS02260	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4A35_RS02275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4A35_RS02285	COG1116	anion transmembrane transporter activity
E4A35_RS02295	COG0488	(ABC) transporter
E4A35_RS02345	COG2270	Major facilitator Superfamily
E4A35_RS02375	COG2310	stress, protein
E4A35_RS02380	COG2310	stress, protein
E4A35_RS02385	COG2310	stress, protein
E4A35_RS02390	COG0861	Integral membrane protein TerC family
E4A35_RS02400	COG3853	Toxic anion resistance protein (TelA)
E4A35_RS02415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4A35_RS02425	COG1295	ribonuclease BN
E4A35_RS02430	COG2217	Heavy metal translocating P-type atpase
E4A35_RS02435	COG0697	spore germination
E4A35_RS02460	COG0586	Pfam SNARE associated Golgi protein
E4A35_RS02475	COG3871	stress protein (general stress protein 26)
E4A35_RS02480	COG0387	Pfam Sodium calcium exchanger
E4A35_RS02490	COG0535	radical SAM domain protein
E4A35_RS02510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E4A35_RS02515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4A35_RS02530	COG3829	transcription factor binding
E4A35_RS02540	COG0833	amino acid
E4A35_RS02545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4A35_RS02575	COG1263	PTS System
E4A35_RS02575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4A35_RS02580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4A35_RS02600	COG0463	Glycosyl transferase, family 2
E4A35_RS02610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4A35_RS02610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4A35_RS02630	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4A35_RS02650	COG1228	amidohydrolase
E4A35_RS02655	COG1090	epimerase
E4A35_RS02685	COG1988	membrane-bound metal-dependent
E4A35_RS02690	COG1194	a g-specific adenine glycosylase
E4A35_RS02715	COG1132	(ABC) transporter
E4A35_RS02720	COG4129	membrane
E4A35_RS02725	COG0067	glutamate synthase
E4A35_RS02725	COG0069	glutamate synthase activity
E4A35_RS02725	COG0070	glutamate synthase
E4A35_RS02735	COG4555	ABC transporter
E4A35_RS02755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4A35_RS02760	COG0735	belongs to the Fur family
E4A35_RS02875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4A35_RS02880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4A35_RS02890	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4A35_RS02900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4A35_RS02910	COG2766	serine protein kinase
E4A35_RS02930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4A35_RS02940	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4A35_RS02945	COG2268	Band 7 protein
E4A35_RS02955	COG3290	protein histidine kinase activity
E4A35_RS02960	COG4565	transcriptional regulatory protein
E4A35_RS02965	COG2851	Citrate transporter
E4A35_RS02985	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E4A35_RS02990	COG3842	ATPase activity
E4A35_RS02995	COG1175	transmembrane transport
E4A35_RS03000	COG0395	ABC-type sugar transport system, permease component
E4A35_RS03010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4A35_RS03015	COG0745	RESPONSE REGULATOR receiver
E4A35_RS03020	COG5002	protein histidine kinase activity
E4A35_RS03030	COG4990	cell redox homeostasis
E4A35_RS03040	COG3290	protein histidine kinase activity
E4A35_RS03045	COG4565	transcriptional regulatory protein
E4A35_RS03050	COG3493	citrate carrier protein
E4A35_RS03055	COG0281	malic enzyme
E4A35_RS03070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4A35_RS03080	COG5002	protein histidine kinase activity
E4A35_RS03085	COG0745	RESPONSE REGULATOR receiver
E4A35_RS03090	COG0456	acetyltransferase
E4A35_RS03090	COG0454	-acetyltransferase
E4A35_RS03095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4A35_RS03100	COG3383	formate dehydrogenase (NAD+) activity
E4A35_RS03105	COG2427	Protein of unknown function (DUF1641)
E4A35_RS03120	COG0531	amino acid
E4A35_RS03125	COG0640	Transcriptional regulator
E4A35_RS03130	COG2217	Heavy metal translocating P-type atpase
E4A35_RS03135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4A35_RS03150	COG3227	Zinc metalloprotease (Elastase)
E4A35_RS03170	COG2720	vancomycin resistance protein
E4A35_RS03175	COG1316	TRANSCRIPTIONal
E4A35_RS03180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4A35_RS03185	COG0346	lactoylglutathione lyase activity
E4A35_RS03190	COG1253	flavin adenine dinucleotide binding
E4A35_RS03195	COG1027	Aspartate ammonia-lyase
E4A35_RS03200	COG1620	l-lactate permease
E4A35_RS03215	COG3104	oligopeptide transport
E4A35_RS03220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4A35_RS03225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4A35_RS03230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4A35_RS03240	COG2226	methyltransferase
E4A35_RS03245	COG0156	8-amino-7-oxononanoate synthase activity
E4A35_RS03250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4A35_RS03255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4A35_RS03265	COG4548	von Willebrand factor, type A
E4A35_RS03270	COG0714	Associated with various cellular activities
E4A35_RS03275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4A35_RS03295	COG0531	amino acid
E4A35_RS03300	COG2188	Transcriptional regulator
E4A35_RS03305	COG1263	PTS System
E4A35_RS03305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4A35_RS03310	COG0366	Alpha amylase catalytic
E4A35_RS03325	COG0697	spore germination
E4A35_RS03335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4A35_RS03340	COG1115	amino acid carrier protein
E4A35_RS03345	COG1126	abc transporter atp-binding protein
E4A35_RS03350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4A35_RS03355	COG0765	amino acid transport
E4A35_RS03360	COG0765	amino acid transport
E4A35_RS03365	COG0833	amino acid
E4A35_RS03390	COG2378	regulation of single-species biofilm formation
E4A35_RS03395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4A35_RS03400	COG5002	protein histidine kinase activity
E4A35_RS03415	COG0659	secondary active sulfate transmembrane transporter activity
E4A35_RS03430	COG0747	negative chemotaxis
E4A35_RS03440	COG0601	transmembrane transport
E4A35_RS03445	COG4608	Belongs to the ABC transporter superfamily
E4A35_RS03455	COG2271	Major facilitator Superfamily
E4A35_RS03460	COG1846	Transcriptional regulator
E4A35_RS03465	COG0477	Major facilitator Superfamily
E4A35_RS03470	COG1609	Transcriptional regulator
E4A35_RS03475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4A35_RS03490	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4A35_RS03495	COG1879	ABC-type sugar transport system periplasmic component
E4A35_RS03530	COG1063	alcohol dehydrogenase
E4A35_RS03545	COG3568	Endonuclease Exonuclease Phosphatase
E4A35_RS03575	COG0840	transmembrane signaling receptor activity
E4A35_RS03580	COG3584	3D domain protein
E4A35_RS03580	COG1388	LysM domain
E4A35_RS03585	COG1476	TRANSCRIPTIONal
E4A35_RS03605	COG3104	oligopeptide transport
E4A35_RS03610	COG1114	Component of the transport system for branched-chain amino acids
E4A35_RS03625	COG1113	amino acid transport
E4A35_RS03630	COG2252	PERMEase
E4A35_RS03645	COG2153	protein acetylation
E4A35_RS03655	COG0569	domain protein
E4A35_RS03655	COG0475	glutathione-regulated potassium exporter activity
E4A35_RS03670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4A35_RS03675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4A35_RS03680	COG0833	amino acid
E4A35_RS03685	COG4990	cell redox homeostasis
E4A35_RS03700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4A35_RS03705	COG0697	spore germination
E4A35_RS03710	COG0531	amino acid
E4A35_RS03720	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4A35_RS03725	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4A35_RS03730	COG1918	ferrous iron import across plasma membrane
E4A35_RS03730	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4A35_RS03735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4A35_RS03740	COG0573	inorganic phosphate transmembrane transporter activity
E4A35_RS03745	COG0581	inorganic phosphate transmembrane transporter activity
E4A35_RS03755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4A35_RS03875	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
E4A35_RS03895	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E4A35_RS03900	COG1116	anion transmembrane transporter activity
E4A35_RS03905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4A35_RS03910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4A35_RS03915	COG0352	thiamine-phosphate diphosphorylase activity
E4A35_RS03920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4A35_RS03925	COG2104	thiamine diphosphate biosynthetic process
E4A35_RS03935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4A35_RS03940	COG0351	phosphomethylpyrimidine kinase
E4A35_RS03980	COG2205	protein histidine kinase activity
E4A35_RS03985	COG2814	Major facilitator Superfamily
E4A35_RS03990	COG1846	Transcriptional regulator
E4A35_RS04015	COG0577	efflux transmembrane transporter activity
E4A35_RS04015	COG1136	(ABC) transporter
E4A35_RS04025	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4A35_RS04035	COG1879	ABC-type sugar transport system periplasmic component
E4A35_RS04040	COG2252	PERMEase
E4A35_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS04050	COG1376	ErfK ybiS ycfS ynhG family protein
E4A35_RS04065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4A35_RS04105	COG0778	Nitroreductase
E4A35_RS04110	COG2719	SpoVR family
E4A35_RS04125	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4A35_RS04130	COG1937	Protein conserved in bacteria
E4A35_RS04135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4A35_RS04135	COG0425	Belongs to the sulfur carrier protein TusA family
E4A35_RS04140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4A35_RS04140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4A35_RS04145	COG0425	Belongs to the sulfur carrier protein TusA family
E4A35_RS04150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4A35_RS04160	COG2210	Belongs to the sulfur carrier protein TusA family
E4A35_RS04165	COG0730	response to heat
E4A35_RS04175	COG1316	TRANSCRIPTIONal
E4A35_RS04180	COG0604	alcohol dehydrogenase
E4A35_RS04185	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4A35_RS04200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4A35_RS04200	COG3711	transcriptional antiterminator
E4A35_RS04205	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4A35_RS04210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4A35_RS04230	COG1388	LysM domain
E4A35_RS04230	COG3584	3D domain protein
E4A35_RS04235	COG0577	efflux transmembrane transporter activity
E4A35_RS04240	COG1136	(ABC) transporter
E4A35_RS04250	COG5522	Integral membrane protein (intg_mem_TP0381)
E4A35_RS04265	COG1114	Component of the transport system for branched-chain amino acids
E4A35_RS04270	COG3546	catalase activity
E4A35_RS04305	COG0586	Pfam SNARE associated Golgi protein
E4A35_RS04335	COG0531	amino acid
E4A35_RS04340	COG0475	glutathione-regulated potassium exporter activity
E4A35_RS04350	COG1737	Transcriptional regulator
E4A35_RS04360	COG1263	PTS System
E4A35_RS04360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4A35_RS04370	COG2259	Doxx family
E4A35_RS04390	COG1522	sequence-specific DNA binding
E4A35_RS04415	COG2076	Multidrug Resistance protein
E4A35_RS04420	COG1309	transcriptional regulator
E4A35_RS04425	COG2814	Major facilitator Superfamily
E4A35_RS04430	COG1733	regulation of RNA biosynthetic process
E4A35_RS04440	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4A35_RS04445	COG4533	DNA binding
E4A35_RS04450	COG2211	Major facilitator Superfamily
E4A35_RS04460	COG0693	protein deglycase activity
E4A35_RS04465	COG0753	catalase activity
E4A35_RS04465	COG0693	protein deglycase activity
E4A35_RS04475	COG0531	amino acid
E4A35_RS04480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4A35_RS04490	COG1012	belongs to the aldehyde dehydrogenase family
E4A35_RS04505	COG1132	(ABC) transporter
E4A35_RS04510	COG1132	(ABC) transporter
E4A35_RS04520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4A35_RS04525	COG0765	amino acid transport
E4A35_RS04530	COG1126	abc transporter atp-binding protein
E4A35_RS04545	COG0189	ligase activity
E4A35_RS04575	COG0028	Belongs to the TPP enzyme family
E4A35_RS04580	COG3527	Alpha-acetolactate decarboxylase
E4A35_RS04590	COG0561	phosphatase activity
E4A35_RS04595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4A35_RS04610	COG0659	secondary active sulfate transmembrane transporter activity
E4A35_RS04640	COG2244	polysaccharide biosynthetic process
E4A35_RS04655	COG4193	domain, Protein
E4A35_RS04655	COG5263	repeat protein
E4A35_RS04670	COG1024	Enoyl-CoA hydratase
E4A35_RS04690	COG1363	Peptidase, m42
E4A35_RS04730	COG1649	PFAM Uncharacterised BCR, COG1649
E4A35_RS04760	COG0601	transmembrane transport
E4A35_RS04765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4A35_RS04770	COG0444	Belongs to the ABC transporter superfamily
E4A35_RS04775	COG4608	Belongs to the ABC transporter superfamily
E4A35_RS04805	COG0556	nucleotide-excision repair
E4A35_RS04860	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4A35_RS04870	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4A35_RS04955	COG0789	Transcriptional regulator
E4A35_RS04955	COG4978	Transcriptional regulator
E4A35_RS04970	COG0305	Participates in initiation and elongation during chromosome replication
E4A35_RS04990	COG0477	Major facilitator Superfamily
E4A35_RS05025	COG1404	Belongs to the peptidase S8 family
E4A35_RS05105	COG1183	phosphatidylcholine synthase activity
E4A35_RS05130	COG2376	Dihydroxyacetone kinase
E4A35_RS05145	COG2376	Dihydroxyacetone kinase
E4A35_RS05185	COG2770	Histidine kinase
E4A35_RS05185	COG3437	response regulator, receiver
E4A35_RS05270	COG1191	sigma factor activity
E4A35_RS05280	COG2208	phosphoserine phosphatase activity
E4A35_RS05285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4A35_RS05290	COG2205	protein histidine kinase activity
E4A35_RS05290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4A35_RS05290	COG0784	Response regulator, receiver
E4A35_RS05290	COG2198	Histidine kinase
E4A35_RS05355	COG0420	3'-5' exonuclease activity
E4A35_RS05360	COG4717	serine-type aminopeptidase activity
E4A35_RS05375	COG0346	lactoylglutathione lyase activity
E4A35_RS05380	COG0346	lactoylglutathione lyase activity
E4A35_RS05395	COG2267	carboxylic ester hydrolase activity
E4A35_RS05415	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E4A35_RS05420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4A35_RS05430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4A35_RS05465	COG0477	Major facilitator Superfamily
E4A35_RS05470	COG0477	Major facilitator Superfamily
E4A35_RS05480	COG3973	AAA domain
E4A35_RS05485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4A35_RS05505	COG4980	gas vesicle protein
E4A35_RS05510	COG0537	adenosine 5'-monophosphoramidase activity
E4A35_RS05515	COG1131	(ABC) transporter
E4A35_RS05520	COG4473	ABC transporter
E4A35_RS05535	COG1309	transcriptional regulator
E4A35_RS05540	COG3402	PFAM membrane-flanked domain
E4A35_RS05545	COG3428	Bacterial PH domain
E4A35_RS05580	COG3402	PFAM membrane-flanked domain
E4A35_RS05585	COG3428	Bacterial PH domain
E4A35_RS05590	COG2329	Antibiotic biosynthesis monooxygenase
E4A35_RS05595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4A35_RS05610	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E4A35_RS05635	COG1309	transcriptional regulator
E4A35_RS05640	COG1511	domain protein
E4A35_RS05655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4A35_RS05665	COG2378	regulation of single-species biofilm formation
E4A35_RS05675	COG1609	Transcriptional regulator
E4A35_RS05685	COG1234	tRNA 3'-trailer cleavage
E4A35_RS05690	COG0095	Lipoate-protein ligase
E4A35_RS05700	COG0318	PFAM AMP-dependent synthetase and ligase
E4A35_RS05720	COG1408	metallophosphoesterase
E4A35_RS05725	COG1078	dGTPase activity
E4A35_RS05735	COG1595	DNA-templated transcription, initiation
E4A35_RS05745	COG3708	Transcriptional regulator
E4A35_RS05745	COG2207	Transcriptional regulator
E4A35_RS05755	COG2205	protein histidine kinase activity
E4A35_RS05760	COG0745	RESPONSE REGULATOR receiver
E4A35_RS05785	COG0501	Belongs to the peptidase M48B family
E4A35_RS05790	COG0697	spore germination
E4A35_RS05810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4A35_RS05815	COG2224	Isocitrate lyase
E4A35_RS05840	COG4903	ComK protein
E4A35_RS05845	COG4585	Histidine kinase
E4A35_RS05850	COG2197	response regulator
E4A35_RS05865	COG0398	Pfam SNARE associated Golgi protein
E4A35_RS05925	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4A35_RS05950	COG0367	asparagine synthase
E4A35_RS05960	COG0753	catalase activity
E4A35_RS05965	COG0004	ammonium transporteR
E4A35_RS05990	COG2996	Protein conserved in bacteria
E4A35_RS05995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4A35_RS06005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4A35_RS06020	COG0561	phosphatase activity
E4A35_RS06030	COG0542	response to heat
E4A35_RS06040	COG2267	carboxylic ester hydrolase activity
E4A35_RS06055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4A35_RS06060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4A35_RS06065	COG5504	Zn-dependent protease
E4A35_RS06075	COG0180	Tryptophanyl-tRNA synthetase
E4A35_RS06090	COG4166	transmembrane transport
E4A35_RS06095	COG0601	transmembrane transport
E4A35_RS06100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4A35_RS06105	COG0444	Belongs to the ABC transporter superfamily
E4A35_RS06110	COG4608	Belongs to the ABC transporter superfamily
E4A35_RS06115	COG0534	Mate efflux family protein
E4A35_RS06120	COG4166	transmembrane transport
E4A35_RS06135	COG0861	Integral membrane protein TerC family
E4A35_RS06140	COG4862	establishment of competence for transformation
E4A35_RS06145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4A35_RS06155	COG1164	Oligoendopeptidase f
E4A35_RS06165	COG2346	COG2346, Truncated hemoglobins
E4A35_RS06170	COG4116	CYTH
E4A35_RS06180	COG2357	RelA SpoT domain protein
E4A35_RS06190	COG0564	pseudouridine synthase activity
E4A35_RS06205	COG0772	Belongs to the SEDS family
E4A35_RS06210	COG1216	Glycosyl transferase, family 2
E4A35_RS06230	COG0463	Glycosyl transferase, family 2
E4A35_RS06230	COG0457	Tetratricopeptide repeat
E4A35_RS06250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4A35_RS06265	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4A35_RS06310	COG2153	protein acetylation
E4A35_RS06320	COG2382	esterase
E4A35_RS06335	COG5492	domain, Protein
E4A35_RS06340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4A35_RS06355	COG0512	Glutamine amidotransferase of anthranilate synthase
E4A35_RS06355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4A35_RS06390	COG1620	l-lactate permease
E4A35_RS06395	COG5634	Uncharacterized conserved protein (DUF2278)
E4A35_RS06445	COG2226	methyltransferase
E4A35_RS06465	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4A35_RS06475	COG1476	TRANSCRIPTIONal
E4A35_RS06520	COG2226	methyltransferase
E4A35_RS06530	COG1686	Belongs to the peptidase S11 family
E4A35_RS06535	COG0681	Belongs to the peptidase S26 family
E4A35_RS06570	COG1012	belongs to the aldehyde dehydrogenase family
E4A35_RS06580	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4A35_RS06585	COG1177	transmembrane transport
E4A35_RS06590	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4A35_RS06600	COG2409	Drug exporters of the RND superfamily
E4A35_RS06610	COG0564	pseudouridine synthase activity
E4A35_RS06620	COG2340	Cysteine-rich secretory protein family
E4A35_RS06625	COG0247	lactate metabolic process
E4A35_RS06630	COG0277	FAD linked oxidase domain protein
E4A35_RS06635	COG3835	regulator
E4A35_RS06645	COG0745	RESPONSE REGULATOR receiver
E4A35_RS06650	COG5002	protein histidine kinase activity
E4A35_RS06655	COG2186	Transcriptional regulator
E4A35_RS06675	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E4A35_RS06685	COG2116	formate transmembrane transporter activity
E4A35_RS06690	COG0861	Integral membrane protein TerC family
E4A35_RS06695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4A35_RS06705	COG2030	dehydratase
E4A35_RS06725	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS06730	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4A35_RS06735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4A35_RS06740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4A35_RS06755	COG1840	ABC-type Fe3 transport system, periplasmic component
E4A35_RS06760	COG3842	ATPase activity
E4A35_RS06785	COG1349	DNA-binding transcription factor activity
E4A35_RS06805	COG2861	carbohydrate metabolic process
E4A35_RS06815	COG3852	Histidine kinase
E4A35_RS06820	COG1846	Transcriptional regulator
E4A35_RS06830	COG2318	DinB family
E4A35_RS06835	COG5002	protein histidine kinase activity
E4A35_RS06845	COG0720	synthase
E4A35_RS06860	COG4873	Protein conserved in bacteria
E4A35_RS06890	COG1780	Probably involved in ribonucleotide reductase function
E4A35_RS06910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4A35_RS06915	COG1725	Transcriptional regulator
E4A35_RS06920	COG1131	(ABC) transporter
E4A35_RS06930	COG1131	(ABC) transporter
E4A35_RS06935	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4A35_RS06950	COG1522	sequence-specific DNA binding
E4A35_RS06960	COG1335	isochorismatase
E4A35_RS06970	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4A35_RS06975	COG2070	2-Nitropropane dioxygenase
E4A35_RS06980	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E4A35_RS06990	COG1696	Membrane protein involved in D-alanine export
E4A35_RS07010	COG0716	FMN binding
E4A35_RS07020	COG3173	Aminoglycoside phosphotransferase
E4A35_RS07040	COG1968	undecaprenyl-diphosphatase activity
E4A35_RS07055	COG1846	Transcriptional regulator
E4A35_RS07065	COG1301	dicarboxylic acid transport
E4A35_RS07070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4A35_RS07075	COG4709	membrane
E4A35_RS07080	COG3874	Sporulation protein YtfJ
E4A35_RS07105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4A35_RS07110	COG0028	Belongs to the TPP enzyme family
E4A35_RS07115	COG0440	acetolactate synthase activity
E4A35_RS07190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4A35_RS07205	COG1183	phosphatidylcholine synthase activity
E4A35_RS07210	COG1368	sulfuric ester hydrolase activity
E4A35_RS07220	COG0019	diaminopimelate decarboxylase activity
E4A35_RS07240	COG0529	Catalyzes the synthesis of activated sulfate
E4A35_RS07245	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4A35_RS07265	COG1648	precorrin-2 dehydrogenase activity
E4A35_RS07270	COG0733	neurotransmitter:sodium symporter activity
E4A35_RS07290	COG1757	Na H antiporter
E4A35_RS07305	COG4758	membrane
E4A35_RS07310	COG4585	Histidine kinase
E4A35_RS07315	COG2197	response regulator
E4A35_RS07325	COG1114	Component of the transport system for branched-chain amino acids
E4A35_RS07335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4A35_RS07375	COG0730	response to heat
E4A35_RS07380	COG0306	phosphate transporter
E4A35_RS07385	COG1392	Phosphate transport regulator
E4A35_RS07390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4A35_RS07405	COG3852	Histidine kinase
E4A35_RS07410	COG1801	Protein of unknown function DUF72
E4A35_RS07420	COG0582	viral genome integration into host DNA
E4A35_RS07425	COG5002	protein histidine kinase activity
E4A35_RS07455	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4A35_RS07455	COG0392	lysyltransferase activity
E4A35_RS07470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4A35_RS07475	COG1686	Belongs to the peptidase S11 family
E4A35_RS07480	COG2715	membrane protein required for spore maturation
E4A35_RS07485	COG0700	Nucleoside recognition
E4A35_RS07490	COG1187	pseudouridine synthase activity
E4A35_RS07500	COG1333	cytochrome c biogenesis protein
E4A35_RS07505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4A35_RS07510	COG0745	RESPONSE REGULATOR receiver
E4A35_RS07515	COG5002	protein histidine kinase activity
E4A35_RS07520	COG2096	Adenosyltransferase
E4A35_RS07525	COG4942	peptidase
E4A35_RS07535	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E4A35_RS07540	COG1141	Ferredoxin
E4A35_RS07550	COG0514	ATP-dependent DNA helicase (RecQ)
E4A35_RS07555	COG1266	CAAX protease self-immunity
E4A35_RS07565	COG1408	metallophosphoesterase
E4A35_RS07575	COG4862	establishment of competence for transformation
E4A35_RS07580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4A35_RS07600	COG0492	ferredoxin-NADP+ reductase activity
E4A35_RS07670	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E4A35_RS07685	COG0142	geranyltranstransferase activity
E4A35_RS07695	COG0142	geranyltranstransferase activity
E4A35_RS07720	COG0457	Tetratricopeptide repeat
E4A35_RS07740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4A35_RS07750	COG4347	Protein of unknown function (DUF1405)
E4A35_RS07765	COG2738	Putative neutral zinc metallopeptidase
E4A35_RS07775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4A35_RS07785	COG1694	Mazg nucleotide pyrophosphohydrolase
E4A35_RS07800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E4A35_RS07805	COG0438	transferase activity, transferring glycosyl groups
E4A35_RS07845	COG1199	ATP-dependent helicase activity
E4A35_RS07845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4A35_RS07865	COG3935	DnaD domain protein
E4A35_RS07870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4A35_RS07880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4A35_RS07880	COG4499	WXG100 protein secretion system (Wss), protein YukC
E4A35_RS07935	COG0116	Belongs to the methyltransferase superfamily
E4A35_RS07945	COG1199	ATP-dependent helicase activity
E4A35_RS07950	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4A35_RS07960	COG3173	Aminoglycoside phosphotransferase
E4A35_RS07965	COG0024	Methionine aminopeptidase
E4A35_RS07975	COG2233	PERMEase
E4A35_RS07980	COG2311	Membrane
E4A35_RS07985	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E4A35_RS07995	COG0456	acetyltransferase
E4A35_RS08030	COG0754	glutathionylspermidine amidase activity
E4A35_RS08045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4A35_RS08070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4A35_RS08085	COG1215	transferase activity, transferring glycosyl groups
E4A35_RS08090	COG0438	transferase activity, transferring glycosyl groups
E4A35_RS08105	COG0454	-acetyltransferase
E4A35_RS08125	COG0328	RNA-DNA hybrid ribonuclease activity
E4A35_RS08160	COG3403	YqcI/YcgG family
E4A35_RS08165	COG1280	lysine exporter protein (LysE YggA)
E4A35_RS08180	COG3162	membrane
E4A35_RS08185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4A35_RS08190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4A35_RS08200	COG0475	glutathione-regulated potassium exporter activity
E4A35_RS08205	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E4A35_RS08210	COG0789	Transcriptional regulator
E4A35_RS08210	COG4978	Transcriptional regulator
E4A35_RS08220	COG2323	membrane
E4A35_RS08225	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4A35_RS08280	COG1923	regulation of RNA biosynthetic process
E4A35_RS08290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4A35_RS08295	COG1360	Flagellar Motor Protein
E4A35_RS08300	COG2201	protein-glutamate methylesterase activity
E4A35_RS08305	COG0643	Histidine kinase
E4A35_RS08305	COG2198	Histidine kinase
E4A35_RS08310	COG1776	CheC inhibitor of MCP methylation
E4A35_RS08310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4A35_RS08325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4A35_RS08345	COG1256	bacterial-type flagellum assembly
E4A35_RS08350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4A35_RS08355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4A35_RS08370	COG1815	bacterial-type flagellum-dependent cell motility
E4A35_RS08375	COG1558	bacterial-type flagellum-dependent cell motility
E4A35_RS08385	COG1766	The M ring may be actively involved in energy transduction
E4A35_RS08390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4A35_RS08400	COG1157	protein secretion by the type III secretion system
E4A35_RS08435	COG0784	Response regulator, receiver
E4A35_RS08435	COG0835	chemotaxis
E4A35_RS08445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4A35_RS08450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4A35_RS08455	COG0741	lytic transglycosylase activity
E4A35_RS08465	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4A35_RS08470	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4A35_RS08470	COG1776	CheC inhibitor of MCP methylation
E4A35_RS08480	COG1338	Plays a role in the flagellum-specific transport system
E4A35_RS08485	COG1987	bacterial-type flagellum assembly
E4A35_RS08495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4A35_RS08500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4A35_RS08505	COG1419	protein localization to endoplasmic reticulum
E4A35_RS08510	COG4786	Flagellar basal body rod
E4A35_RS08515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4A35_RS08550	COG2329	Antibiotic biosynthesis monooxygenase
E4A35_RS08575	COG0583	DNA-binding transcription factor activity
E4A35_RS08580	COG3842	ATPase activity
E4A35_RS08585	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4A35_RS08595	COG1234	tRNA 3'-trailer cleavage
E4A35_RS08625	COG1686	Belongs to the peptidase S11 family
E4A35_RS08635	COG0406	alpha-ribazole phosphatase activity
E4A35_RS08650	COG1846	Transcriptional regulator
E4A35_RS08660	COG0367	asparagine synthase
E4A35_RS08690	COG1802	Transcriptional regulator
E4A35_RS08695	COG0697	spore germination
E4A35_RS08700	COG0523	cobalamin synthesis protein
E4A35_RS08710	COG0701	Predicted permease
E4A35_RS08720	COG1216	Glycosyl transferase, family 2
E4A35_RS08720	COG0438	transferase activity, transferring glycosyl groups
E4A35_RS08725	COG1757	Na H antiporter
E4A35_RS08730	COG0789	Transcriptional regulator
E4A35_RS08740	COG0114	fumarate hydratase activity
E4A35_RS08755	COG0534	Mate efflux family protein
E4A35_RS08760	COG3340	Belongs to the peptidase S51 family
E4A35_RS08780	COG0785	Cytochrome C biogenesis protein
E4A35_RS08810	COG2733	membrane
E4A35_RS08850	COG1131	(ABC) transporter
E4A35_RS08865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4A35_RS08870	COG0528	UMP kinase activity
E4A35_RS08880	COG1027	Aspartate ammonia-lyase
E4A35_RS08885	COG0281	malic enzyme
E4A35_RS08890	COG4191	Histidine kinase
E4A35_RS08895	COG0784	Response regulator, receiver
E4A35_RS08905	COG1361	Conserved repeat domain
E4A35_RS08910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4A35_RS08930	COG3620	sequence-specific DNA binding
E4A35_RS08965	COG2814	Major facilitator Superfamily
E4A35_RS08980	COG1966	Carbon starvation protein
E4A35_RS08990	COG1695	Transcriptional regulator
E4A35_RS09000	COG0477	Major facilitator Superfamily
E4A35_RS09005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4A35_RS09015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4A35_RS09020	COG4166	transmembrane transport
E4A35_RS09025	COG2223	nitrite transmembrane transporter activity
E4A35_RS09030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4A35_RS09045	COG2244	polysaccharide biosynthetic process
E4A35_RS09050	COG0733	neurotransmitter:sodium symporter activity
E4A35_RS09060	COG5566	PFAM Mor transcription activator
E4A35_RS09065	COG2323	membrane
E4A35_RS09080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4A35_RS09090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4A35_RS09095	COG0028	Belongs to the TPP enzyme family
E4A35_RS09100	COG0440	acetolactate synthase activity
E4A35_RS09115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4A35_RS09140	COG2814	Major facilitator Superfamily
E4A35_RS09145	COG3384	dioxygenase
E4A35_RS09155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4A35_RS09160	COG3279	Response regulator of the LytR AlgR family
E4A35_RS09165	COG0427	acetyl-CoA hydrolase
E4A35_RS09185	COG1073	alpha beta
E4A35_RS09190	COG4166	transmembrane transport
E4A35_RS09215	COG0535	radical SAM domain protein
E4A35_RS09220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4A35_RS09240	COG1914	H( )-stimulated, divalent metal cation uptake system
E4A35_RS09255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4A35_RS09260	COG0531	amino acid
E4A35_RS09295	COG0714	Associated with various cellular activities
E4A35_RS09305	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E4A35_RS09330	COG2390	Transcriptional regulator
E4A35_RS09340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4A35_RS09345	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4A35_RS09355	COG4846	Membrane protein involved in cytochrome C biogenesis
E4A35_RS09380	COG0006	proline dipeptidase activity
E4A35_RS09385	COG2132	Multicopper oxidase
E4A35_RS09405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4A35_RS09430	COG1114	Component of the transport system for branched-chain amino acids
E4A35_RS09440	COG2372	response to copper ion
E4A35_RS09440	COG1276	copper resistance
E4A35_RS09445	COG4549	nuclear export factor GLE1
E4A35_RS09455	COG0697	spore germination
E4A35_RS09460	COG0583	DNA-binding transcription factor activity
E4A35_RS09465	COG1959	2 iron, 2 sulfur cluster binding
E4A35_RS09470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4A35_RS09475	COG0778	Nitroreductase
E4A35_RS09485	COG0628	permease
E4A35_RS09495	COG1231	oxidoreductase activity
E4A35_RS09500	COG0523	cobalamin synthesis protein
E4A35_RS09510	COG0411	ABC transporter
E4A35_RS09530	COG0583	DNA-binding transcription factor activity
E4A35_RS09560	COG1271	oxidase subunit
E4A35_RS09565	COG1294	oxidase, subunit
E4A35_RS09570	COG4988	ABC transporter
E4A35_RS09575	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4A35_RS09590	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4A35_RS09595	COG1686	Belongs to the peptidase S11 family
E4A35_RS09610	COG0791	NLP P60 protein
E4A35_RS09610	COG1388	LysM domain
E4A35_RS09620	COG1132	(ABC) transporter
E4A35_RS09625	COG0745	RESPONSE REGULATOR receiver
E4A35_RS09630	COG5002	protein histidine kinase activity
E4A35_RS09640	COG0300	oxidoreductase activity
E4A35_RS09660	COG5658	integral membrane protein
E4A35_RS09680	COG0460	homoserine dehydrogenase
E4A35_RS09705	COG1316	TRANSCRIPTIONal
E4A35_RS09715	COG0745	RESPONSE REGULATOR receiver
E4A35_RS09735	COG1285	pathogenesis
E4A35_RS09740	COG1247	-acetyltransferase
E4A35_RS09760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4A35_RS09770	COG1082	Xylose isomerase domain protein TIM barrel
E4A35_RS09780	COG2814	Major facilitator Superfamily
E4A35_RS09785	COG1279	arginine transmembrane transporter activity
E4A35_RS09795	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4A35_RS09830	COG0577	efflux transmembrane transporter activity
E4A35_RS09835	COG2002	toxin-antitoxin pair type II binding
E4A35_RS09840	COG1404	Belongs to the peptidase S8 family
E4A35_RS09845	COG0640	Transcriptional regulator
E4A35_RS09850	COG0667	Aldo Keto reductase
E4A35_RS09855	COG2814	Major facilitator Superfamily
E4A35_RS09880	COG0840	transmembrane signaling receptor activity
E4A35_RS09895	COG3949	Membrane
E4A35_RS09900	COG0783	Belongs to the Dps family
E4A35_RS09915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4A35_RS09925	COG1231	oxidoreductase activity
E4A35_RS09930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4A35_RS09935	COG4989	oxidoreductase activity
E4A35_RS09940	COG0523	cobalamin synthesis protein
E4A35_RS09945	COG0456	acetyltransferase
E4A35_RS09950	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4A35_RS09950	COG3443	Belongs to the bacterial solute-binding protein 9 family
E4A35_RS09955	COG0702	epimerase
E4A35_RS09965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4A35_RS09975	COG4166	transmembrane transport
E4A35_RS09990	COG0406	alpha-ribazole phosphatase activity
E4A35_RS10000	COG5337	Spore coat protein CotH
E4A35_RS10005	COG1051	belongs to the nudix hydrolase family
E4A35_RS10010	COG0586	Pfam SNARE associated Golgi protein
E4A35_RS10015	COG2244	polysaccharide biosynthetic process
E4A35_RS10025	COG0701	Predicted permease
E4A35_RS10030	COG3689	TIGRFAM TIGR03943 family protein
E4A35_RS10035	COG1607	acyl-coa hydrolase
E4A35_RS10045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4A35_RS10060	COG0702	epimerase
E4A35_RS10070	COG1253	flavin adenine dinucleotide binding
E4A35_RS10085	COG1114	Component of the transport system for branched-chain amino acids
E4A35_RS10090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4A35_RS10110	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4A35_RS10120	COG1876	peptidase activity
E4A35_RS10130	COG0154	amidase activity
E4A35_RS10135	COG2211	Major facilitator Superfamily
E4A35_RS10155	COG0561	phosphatase activity
E4A35_RS10165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4A35_RS10170	COG4106	trans-aconitate 2-methyltransferase activity
E4A35_RS10185	COG1819	glycosyl
E4A35_RS10190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4A35_RS10195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4A35_RS10220	COG0456	acetyltransferase
E4A35_RS10260	COG4499	WXG100 protein secretion system (Wss), protein YukC
E4A35_RS10360	COG3874	Sporulation protein YtfJ
E4A35_RS10385	COG2226	methyltransferase
E4A35_RS10405	COG1082	Xylose isomerase domain protein TIM barrel
E4A35_RS10410	COG0346	lactoylglutathione lyase activity
E4A35_RS10420	COG0604	alcohol dehydrogenase
E4A35_RS10425	COG1595	DNA-templated transcription, initiation
E4A35_RS10460	COG0386	Belongs to the glutathione peroxidase family
E4A35_RS10465	COG1305	Transglutaminase-like
E4A35_RS10470	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
E4A35_RS10475	COG0714	Associated with various cellular activities
E4A35_RS10480	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4A35_RS10485	COG1140	nitrate reductase beta subunit
E4A35_RS10490	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4A35_RS10495	COG2181	nitrate reductase activity
E4A35_RS10500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4A35_RS10505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4A35_RS10510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4A35_RS10515	COG0303	'Molybdopterin
E4A35_RS10520	COG0314	molybdopterin synthase activity
E4A35_RS10530	COG2223	nitrite transmembrane transporter activity
E4A35_RS10540	COG1648	precorrin-2 dehydrogenase activity
E4A35_RS10550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4A35_RS10550	COG1587	Uroporphyrinogen-III synthase
E4A35_RS10555	COG2146	nitrite reductase [NAD(P)H] activity
E4A35_RS10560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4A35_RS10565	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
E4A35_RS10605	COG2359	stage V sporulation protein S
E4A35_RS10625	COG1418	mRNA catabolic process
E4A35_RS10630	COG0488	(ABC) transporter
E4A35_RS10650	COG1413	lyase activity
E4A35_RS10665	COG2521	methyltransferase
E4A35_RS10665	COG2136	Putative SAM-dependent methyltransferase
E4A35_RS10705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4A35_RS10715	COG0017	Asparaginyl-tRNA synthetase
E4A35_RS10720	COG1929	Belongs to the glycerate kinase type-1 family
E4A35_RS10725	COG0471	metal ion transport
E4A35_RS10730	COG0745	RESPONSE REGULATOR receiver
E4A35_RS10735	COG3850	Histidine kinase
E4A35_RS10735	COG5002	protein histidine kinase activity
E4A35_RS10750	COG0733	neurotransmitter:sodium symporter activity
E4A35_RS10775	COG2610	gluconate transmembrane transporter activity
E4A35_RS10780	COG1454	alcohol dehydrogenase
E4A35_RS10785	COG1794	racemase activity, acting on amino acids and derivatives
E4A35_RS10795	COG0456	acetyltransferase
E4A35_RS10800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4A35_RS10810	COG1131	(ABC) transporter
E4A35_RS10815	COG4473	ABC transporter
E4A35_RS10825	COG0546	phosphoglycolate phosphatase activity
E4A35_RS10845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4A35_RS10860	COG0768	penicillin binding
E4A35_RS10870	COG0204	Acyl-transferase
E4A35_RS10875	COG1272	protein, Hemolysin III
E4A35_RS10885	COG0805	protein transport
E4A35_RS10895	COG1307	EDD domain protein, DegV family
E4A35_RS10900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4A35_RS10905	COG1999	signal sequence binding
E4A35_RS10910	COG0071	Belongs to the small heat shock protein (HSP20) family
E4A35_RS10915	COG0367	asparagine synthase
E4A35_RS10930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4A35_RS10935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4A35_RS10955	COG1335	isochorismatase
E4A35_RS10960	COG1051	belongs to the nudix hydrolase family
E4A35_RS10965	COG0071	Belongs to the small heat shock protein (HSP20) family
E4A35_RS10970	COG0668	transmembrane transport
E4A35_RS10975	COG2203	Gaf domain
E4A35_RS10975	COG4585	Histidine kinase
E4A35_RS10980	COG2197	response regulator
E4A35_RS10990	COG1064	alcohol dehydrogenase
E4A35_RS11015	COG1070	Carbohydrate kinase
E4A35_RS11020	COG1070	Carbohydrate kinase
E4A35_RS11050	COG1125	glycine betaine transport
E4A35_RS11050	COG0517	IMP dehydrogenase activity
E4A35_RS11055	COG1174	glycine betaine transport
E4A35_RS11090	COG1253	flavin adenine dinucleotide binding
E4A35_RS11095	COG1012	belongs to the aldehyde dehydrogenase family
E4A35_RS11100	COG5506	Protein of unknown function (DUF1694)
E4A35_RS11105	COG3852	Histidine kinase
E4A35_RS11115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4A35_RS11120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4A35_RS11125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4A35_RS11130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4A35_RS11135	COG0456	acetyltransferase
E4A35_RS11140	COG3829	transcription factor binding
E4A35_RS11150	COG1509	lysine 2,3-aminomutase activity
E4A35_RS11190	COG4326	sporulation control protein
E4A35_RS11195	COG0671	phosphoesterase, PA-phosphatase related
E4A35_RS11200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4A35_RS11205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4A35_RS11275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4A35_RS11320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4A35_RS11320	COG4499	WXG100 protein secretion system (Wss), protein YukC
E4A35_RS11325	COG2814	Major facilitator Superfamily
E4A35_RS11330	COG4841	protein insertion into membrane
E4A35_RS11335	COG0372	Belongs to the citrate synthase family
E4A35_RS11340	COG2079	MmgE PrpD family protein
E4A35_RS11345	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4A35_RS11350	COG1960	acyl-CoA dehydrogenase activity
E4A35_RS11365	COG1280	lysine exporter protein (LysE YggA)
E4A35_RS11370	COG1024	Enoyl-CoA hydratase
E4A35_RS11385	COG0420	3'-5' exonuclease activity
E4A35_RS11390	COG0419	ATPase involved in DNA repair
E4A35_RS11410	COG2223	nitrite transmembrane transporter activity
E4A35_RS11420	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS11425	COG1169	isochorismate synthase
E4A35_RS11430	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4A35_RS11435	COG3433	isochorismatase activity
E4A35_RS11435	COG1535	isochorismatase
E4A35_RS11440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4A35_RS11445	COG3251	PFAM MbtH domain protein
E4A35_RS11450	COG2814	Major facilitator Superfamily
E4A35_RS11465	COG0776	regulation of translation
E4A35_RS11475	COG2318	DinB family
E4A35_RS11485	COG1115	amino acid carrier protein
E4A35_RS11500	COG2329	Antibiotic biosynthesis monooxygenase
E4A35_RS11505	COG1187	pseudouridine synthase activity
E4A35_RS11510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4A35_RS11515	COG1136	(ABC) transporter
E4A35_RS11525	COG0596	Alpha beta hydrolase
E4A35_RS11530	COG2814	Major facilitator Superfamily
E4A35_RS11550	COG2226	methyltransferase
E4A35_RS11595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4A35_RS11630	COG1247	-acetyltransferase
E4A35_RS11640	COG0640	Transcriptional regulator
E4A35_RS11655	COG2072	flavoprotein involved in K transport
E4A35_RS11670	COG0640	Transcriptional regulator
E4A35_RS11675	COG0798	PFAM Bile acid sodium symporter
E4A35_RS11750	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E4A35_RS11760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4A35_RS11770	COG1278	Cold shock
E4A35_RS11785	COG0010	Belongs to the arginase family
E4A35_RS11790	COG0561	phosphatase activity
E4A35_RS11835	COG0583	DNA-binding transcription factor activity
E4A35_RS11840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4A35_RS11855	COG0583	DNA-binding transcription factor activity
E4A35_RS11860	COG2258	MOSC domain
E4A35_RS11875	COG1132	(ABC) transporter
E4A35_RS11880	COG1132	(ABC) transporter
E4A35_RS11900	COG1396	sequence-specific DNA binding
E4A35_RS11930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4A35_RS11940	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E4A35_RS11945	COG1595	DNA-templated transcription, initiation
E4A35_RS11965	COG1649	PFAM Uncharacterised BCR, COG1649
E4A35_RS11990	COG2971	BadF BadG BcrA BcrD
E4A35_RS12000	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4A35_RS12040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4A35_RS12070	COG1309	transcriptional regulator
E4A35_RS12085	COG1136	(ABC) transporter
E4A35_RS12085	COG0577	efflux transmembrane transporter activity
E4A35_RS12090	COG0500	methyltransferase
E4A35_RS12090	COG3615	Tellurite resistance protein tehB
E4A35_RS12100	COG3961	Belongs to the TPP enzyme family
E4A35_RS12105	COG1846	Transcriptional regulator
E4A35_RS12135	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4A35_RS12150	COG1595	DNA-templated transcription, initiation
E4A35_RS12160	COG0768	penicillin binding
E4A35_RS12165	COG0768	penicillin binding
E4A35_RS12170	COG2367	Beta-lactamase
E4A35_RS12175	COG0671	phosphoesterase, PA-phosphatase related
E4A35_RS12180	COG1609	Transcriptional regulator
E4A35_RS12185	COG2814	Major facilitator Superfamily
E4A35_RS12190	COG0673	inositol 2-dehydrogenase activity
E4A35_RS12220	COG3718	enzyme involved in inositol metabolism
E4A35_RS12235	COG0737	Belongs to the 5'-nucleotidase family
E4A35_RS12245	COG0457	Tetratricopeptide repeat
E4A35_RS12250	COG1476	TRANSCRIPTIONal
E4A35_RS12270	COG1876	peptidase activity
E4A35_RS12290	COG1309	transcriptional regulator
E4A35_RS12295	COG0488	(ABC) transporter
E4A35_RS12340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4A35_RS12355	COG1131	(ABC) transporter
E4A35_RS12365	COG1309	transcriptional regulator
E4A35_RS12380	COG1960	acyl-CoA dehydrogenase activity
E4A35_RS12385	COG0439	Biotin carboxylase
E4A35_RS12390	COG0511	ligase activity, forming carbon-carbon bonds
E4A35_RS12395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4A35_RS12400	COG1024	Enoyl-CoA hydratase
E4A35_RS12405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4A35_RS12410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4A35_RS12420	COG1247	-acetyltransferase
E4A35_RS12425	COG0572	uridine kinase
E4A35_RS12435	COG2318	DinB family
E4A35_RS12440	COG1686	Belongs to the peptidase S11 family
E4A35_RS12465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4A35_RS12485	COG3227	Zinc metalloprotease (Elastase)
E4A35_RS12500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4A35_RS12525	COG2814	Major facilitator Superfamily
E4A35_RS12540	COG2226	methyltransferase
E4A35_RS12555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4A35_RS12575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4A35_RS12590	COG1063	alcohol dehydrogenase
E4A35_RS12615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4A35_RS12625	COG3386	PFAM SMP-30 Gluconolaconase
E4A35_RS12635	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4A35_RS12650	COG0745	RESPONSE REGULATOR receiver
E4A35_RS12655	COG2205	protein histidine kinase activity
E4A35_RS12665	COG0488	(ABC) transporter
E4A35_RS12680	COG1136	(ABC) transporter
E4A35_RS12685	COG0577	efflux transmembrane transporter activity
E4A35_RS12705	COG0460	homoserine dehydrogenase
E4A35_RS12710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4A35_RS12720	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E4A35_RS12790	COG2124	cytochrome p450
E4A35_RS12825	COG0561	phosphatase activity
E4A35_RS12830	COG5002	protein histidine kinase activity
E4A35_RS12835	COG0768	penicillin binding
E4A35_RS12840	COG1819	glycosyl
E4A35_RS12845	COG1794	racemase activity, acting on amino acids and derivatives
E4A35_RS12870	COG2205	protein histidine kinase activity
E4A35_RS12880	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E4A35_RS12885	COG0604	alcohol dehydrogenase
E4A35_RS12890	COG0768	penicillin binding
E4A35_RS12905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4A35_RS12940	COG0693	protein deglycase activity
E4A35_RS12965	COG2814	Major facilitator Superfamily
E4A35_RS12980	COG0584	glycerophosphoryl diester phosphodiesterase
E4A35_RS12995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4A35_RS13000	COG0697	spore germination
E4A35_RS13020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4A35_RS13025	COG2223	nitrite transmembrane transporter activity
E4A35_RS13030	COG2816	NAD+ diphosphatase activity
E4A35_RS13035	COG0592	DNA-directed DNA polymerase activity
E4A35_RS13040	COG1051	belongs to the nudix hydrolase family
E4A35_RS13070	COG0406	alpha-ribazole phosphatase activity
E4A35_RS13080	COG3878	Protein conserved in bacteria
E4A35_RS13100	COG4667	esterase of the alpha-beta hydrolase superfamily
E4A35_RS13125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4A35_RS13140	COG0322	excinuclease ABC activity
E4A35_RS13180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4A35_RS13205	COG1011	Hydrolase
E4A35_RS13230	COG1523	belongs to the glycosyl hydrolase 13 family
E4A35_RS13235	COG3227	Zinc metalloprotease (Elastase)
E4A35_RS13255	COG0201	protein transport
E4A35_RS13265	COG0697	spore germination
E4A35_RS13270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4A35_RS13315	COG4974	Belongs to the 'phage' integrase family
E4A35_RS13340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4A35_RS13355	COG2959	enzyme of heme biosynthesis
E4A35_RS13380	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E4A35_RS13385	COG3844	kynureninase activity
E4A35_RS13390	COG1309	transcriptional regulator
E4A35_RS13425	COG3284	Transcriptional regulator
E4A35_RS13440	COG1349	DNA-binding transcription factor activity
E4A35_RS13450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4A35_RS13455	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4A35_RS13460	COG0022	dehydrogenase e1 component
E4A35_RS13465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4A35_RS13475	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS13480	COG0456	acetyltransferase
E4A35_RS13480	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E4A35_RS13485	COG0572	uridine kinase
E4A35_RS13515	COG4176	ABC-type proline glycine betaine transport system permease component
E4A35_RS13520	COG0517	IMP dehydrogenase activity
E4A35_RS13520	COG4175	Glycine betaine
E4A35_RS13550	COG2153	protein acetylation
E4A35_RS13555	COG3397	chitin binding
E4A35_RS13570	COG2205	protein histidine kinase activity
E4A35_RS13575	COG2226	methyltransferase
E4A35_RS13595	COG0658	competence protein
E4A35_RS13595	COG2333	competence protein COMEC
E4A35_RS13645	COG3973	AAA domain
E4A35_RS13660	COG2105	PFAM AIG2 family protein
E4A35_RS13665	COG0514	ATP-dependent DNA helicase (RecQ)
E4A35_RS13695	COG4637	Psort location Cytoplasmic, score
E4A35_RS13715	COG3397	chitin binding
E4A35_RS13730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4A35_RS13735	COG1115	amino acid carrier protein
E4A35_RS13740	COG1012	belongs to the aldehyde dehydrogenase family
E4A35_RS13745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4A35_RS13755	COG3938	Belongs to the proline racemase family
E4A35_RS13760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4A35_RS13800	COG0586	Pfam SNARE associated Golgi protein
E4A35_RS13815	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E4A35_RS13820	COG0519	Catalyzes the synthesis of GMP from XMP
E4A35_RS13825	COG4166	transmembrane transport
E4A35_RS13835	COG4948	Mandelate Racemase Muconate Lactonizing
E4A35_RS13885	COG2936	dipeptidyl-peptidase activity
E4A35_RS13890	COG5002	protein histidine kinase activity
E4A35_RS13895	COG0745	RESPONSE REGULATOR receiver
E4A35_RS13940	COG1307	EDD domain protein, DegV family
E4A35_RS13960	COG2814	Major facilitator Superfamily
E4A35_RS13970	COG1664	Polymer-forming cytoskeletal
E4A35_RS13975	COG0789	Transcriptional regulator
E4A35_RS13980	COG4533	DNA binding
E4A35_RS13985	COG2814	Major facilitator Superfamily
E4A35_RS13985	COG0477	Major facilitator Superfamily
E4A35_RS14005	COG2261	transglycosylase associated protein
E4A35_RS14020	COG2226	methyltransferase
E4A35_RS14060	COG0436	Aminotransferase
E4A35_RS14065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4A35_RS14075	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4A35_RS14090	COG1131	(ABC) transporter
E4A35_RS14130	COG0628	permease
E4A35_RS14140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4A35_RS14145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4A35_RS14150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4A35_RS14175	COG2816	NAD+ diphosphatase activity
E4A35_RS14195	COG2746	aminoglycoside 3-N-acetyltransferase activity
E4A35_RS14220	COG0697	spore germination
E4A35_RS14225	COG2318	DinB family
E4A35_RS14265	COG0861	Integral membrane protein TerC family
E4A35_RS14270	COG1368	sulfuric ester hydrolase activity
E4A35_RS14280	COG0488	(ABC) transporter
E4A35_RS14290	COG1033	growth of symbiont in host cell
E4A35_RS14290	COG2409	Drug exporters of the RND superfamily
E4A35_RS14295	COG1309	transcriptional regulator
E4A35_RS14310	COG0287	Prephenate dehydrogenase
E4A35_RS14325	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E4A35_RS14325	COG1605	Chorismate mutase
E4A35_RS14360	COG1388	LysM domain
E4A35_RS14360	COG3584	3D domain protein
E4A35_RS14370	COG1595	DNA-templated transcription, initiation
E4A35_RS14395	COG1879	ABC-type sugar transport system periplasmic component
E4A35_RS14405	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4A35_RS14415	COG2390	Transcriptional regulator
E4A35_RS14420	COG1070	Carbohydrate kinase
E4A35_RS14450	COG2329	Antibiotic biosynthesis monooxygenase
E4A35_RS14470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4A35_RS14485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4A35_RS14490	COG4187	Peptidase family M20/M25/M40
E4A35_RS14495	COG1414	Transcriptional regulator
E4A35_RS14505	COG0833	amino acid
E4A35_RS14515	COG3239	Fatty acid desaturase
E4A35_RS14520	COG1785	Belongs to the alkaline phosphatase family
E4A35_RS14530	COG3655	Transcriptional regulator
E4A35_RS14545	COG4377	Putative membrane peptidase family (DUF2324)
E4A35_RS14555	COG3279	Response regulator of the LytR AlgR family
E4A35_RS14580	COG0346	lactoylglutathione lyase activity
E4A35_RS14605	COG0714	Associated with various cellular activities
E4A35_RS14630	COG0463	Glycosyl transferase, family 2
E4A35_RS14650	COG0463	Glycosyl transferase, family 2
E4A35_RS14665	COG0753	catalase activity
E4A35_RS14670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4A35_RS14675	COG1116	anion transmembrane transporter activity
E4A35_RS14690	COG1846	Transcriptional regulator
E4A35_RS14695	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E4A35_RS14705	COG1280	lysine exporter protein (LysE YggA)
E4A35_RS14730	COG0714	Associated with various cellular activities
E4A35_RS14835	COG0778	Nitroreductase
E4A35_RS14840	COG1846	Transcriptional regulator
E4A35_RS14885	COG1725	Transcriptional regulator
E4A35_RS14905	COG1136	(ABC) transporter
E4A35_RS14905	COG0577	efflux transmembrane transporter activity
E4A35_RS14930	COG2207	Transcriptional regulator
E4A35_RS14935	COG0456	acetyltransferase
E4A35_RS14955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4A35_RS14970	COG0642	Histidine kinase
E4A35_RS14975	COG0745	RESPONSE REGULATOR receiver
E4A35_RS14980	COG0596	Alpha beta hydrolase
E4A35_RS15010	COG0730	response to heat
E4A35_RS15020	COG0833	amino acid
E4A35_RS15030	COG4335	DNA alkylation repair
E4A35_RS15065	COG0768	penicillin binding
E4A35_RS15095	COG1984	allophanate hydrolase subunit 2
E4A35_RS15100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4A35_RS15105	COG1414	Transcriptional regulator
E4A35_RS15125	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4A35_RS15130	COG0640	Transcriptional regulator
E4A35_RS15140	COG1960	acyl-CoA dehydrogenase activity
E4A35_RS15155	COG3314	Sporulation integral membrane protein YlbJ
E4A35_RS15170	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
E4A35_RS15185	COG3848	Pyruvate phosphate dikinase
E4A35_RS15185	COG0574	Belongs to the PEP-utilizing enzyme family
E4A35_RS15215	COG0252	asparaginase activity
E4A35_RS15220	COG1396	sequence-specific DNA binding
E4A35_RS15230	COG0322	excinuclease ABC activity
E4A35_RS15235	COG0531	amino acid
E4A35_RS15240	COG1114	Component of the transport system for branched-chain amino acids
E4A35_RS15245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4A35_RS15260	COG0531	amino acid
E4A35_RS15265	COG0697	spore germination
E4A35_RS15270	COG0784	Response regulator, receiver
E4A35_RS15275	COG4191	Histidine kinase
E4A35_RS15280	COG2066	Belongs to the glutaminase family
E4A35_RS15285	COG1115	amino acid carrier protein
E4A35_RS15315	COG0737	Belongs to the 5'-nucleotidase family
E4A35_RS15320	COG0753	catalase activity
E4A35_RS15325	COG2267	carboxylic ester hydrolase activity
E4A35_RS15330	COG1335	isochorismatase
E4A35_RS15350	COG0583	DNA-binding transcription factor activity
E4A35_RS15365	COG0598	Magnesium transport protein CorA
E4A35_RS15400	COG0583	DNA-binding transcription factor activity
E4A35_RS15435	COG0415	Belongs to the DNA photolyase family
E4A35_RS15440	COG0288	reversible hydration of carbon dioxide
E4A35_RS15450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4A35_RS15455	COG5609	conserved protein (DUF2294)
E4A35_RS15470	COG0714	Associated with various cellular activities
E4A35_RS15505	COG1575	Belongs to the MenA family. Type 1 subfamily
E4A35_RS15520	COG2211	Major facilitator Superfamily
E4A35_RS15535	COG4641	Protein conserved in bacteria
E4A35_RS15540	COG1136	(ABC) transporter
E4A35_RS15545	COG0577	efflux transmembrane transporter activity
E4A35_RS15580	COG0798	PFAM Bile acid sodium symporter
E4A35_RS15585	COG0346	lactoylglutathione lyase activity
E4A35_RS15590	COG0640	Transcriptional regulator
E4A35_RS15610	COG5002	protein histidine kinase activity
E4A35_RS15615	COG0745	RESPONSE REGULATOR receiver
E4A35_RS15625	COG0456	acetyltransferase
E4A35_RS15635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4A35_RS15635	COG3320	Male sterility
E4A35_RS15640	COG1309	transcriptional regulator
E4A35_RS15645	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS15650	COG1522	sequence-specific DNA binding
E4A35_RS15665	COG0346	lactoylglutathione lyase activity
E4A35_RS15705	COG2814	Major facilitator Superfamily
E4A35_RS15715	COG4895	conserved protein (DUF2196)
E4A35_RS15770	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E4A35_RS15800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4A35_RS15805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4A35_RS15815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4A35_RS15830	COG2309	aminopeptidase activity
E4A35_RS15845	COG0789	Transcriptional regulator
E4A35_RS15850	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4A35_RS15870	COG0577	efflux transmembrane transporter activity
E4A35_RS15885	COG5002	protein histidine kinase activity
E4A35_RS15885	COG3850	Histidine kinase
E4A35_RS15895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4A35_RS15915	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4A35_RS15930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4A35_RS15950	COG1595	DNA-templated transcription, initiation
E4A35_RS15965	COG0662	Cupin 2, conserved barrel domain protein
E4A35_RS15975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4A35_RS15975	COG2207	Transcriptional regulator
E4A35_RS15990	COG3409	Peptidoglycan-binding domain 1 protein
E4A35_RS15990	COG5632	N-Acetylmuramoyl-L-alanine amidase
E4A35_RS16065	COG4282	regulation of fungal-type cell wall biogenesis
E4A35_RS16155	COG5444	nuclease activity
E4A35_RS16250	COG2849	repeat protein
E4A35_RS16295	COG5444	nuclease activity
E4A35_RS16320	COG2373	Large extracellular alpha-helical protein
E4A35_RS16340	COG0477	Major facilitator Superfamily
E4A35_RS16350	COG1846	Transcriptional regulator
E4A35_RS16355	COG2814	Major facilitator Superfamily
E4A35_RS16365	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4A35_RS16370	COG1131	(ABC) transporter
E4A35_RS16390	COG2076	Multidrug Resistance protein
E4A35_RS16395	COG1309	transcriptional regulator
E4A35_RS16410	COG2031	fatty acid transporter
E4A35_RS16420	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4A35_RS16455	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E4A35_RS16470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4A35_RS16480	COG3409	Peptidoglycan-binding domain 1 protein
E4A35_RS16480	COG5632	N-Acetylmuramoyl-L-alanine amidase
E4A35_RS16510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4A35_RS16525	COG2197	response regulator
E4A35_RS16530	COG0124	histidyl-tRNA synthetase
E4A35_RS16545	COG1733	regulation of RNA biosynthetic process
E4A35_RS16550	COG0778	Nitroreductase
E4A35_RS16570	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS16580	COG1131	(ABC) transporter
E4A35_RS16605	COG1011	Hydrolase
E4A35_RS16615	COG2365	Tyrosine phosphatase family
E4A35_RS16635	COG0346	lactoylglutathione lyase activity
E4A35_RS16640	COG1940	carbohydrate kinase activity
E4A35_RS16645	COG0738	Major facilitator superfamily
E4A35_RS16650	COG0110	maltose O-acetyltransferase activity
E4A35_RS16665	COG0628	permease
E4A35_RS16680	COG2226	methyltransferase
E4A35_RS16690	COG0477	Major facilitator Superfamily
E4A35_RS16720	COG1253	flavin adenine dinucleotide binding
E4A35_RS16725	COG0789	Transcriptional regulator
E4A35_RS16730	COG0697	spore germination
E4A35_RS16735	COG1357	PFAM Pentapeptide repeats (8 copies)
E4A35_RS16740	COG3813	Protein conserved in bacteria
E4A35_RS16750	COG2706	6-phosphogluconolactonase activity
E4A35_RS16755	COG1070	Carbohydrate kinase
E4A35_RS16765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4A35_RS16770	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E4A35_RS16780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4A35_RS16790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4A35_RS16810	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS16825	COG0840	transmembrane signaling receptor activity
E4A35_RS16835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4A35_RS16835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4A35_RS16840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4A35_RS16840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4A35_RS16845	COG1733	regulation of RNA biosynthetic process
E4A35_RS16875	COG0814	amino acid
E4A35_RS16905	COG1393	Belongs to the ArsC family
E4A35_RS16915	COG2188	Transcriptional regulator
E4A35_RS16920	COG0673	inositol 2-dehydrogenase activity
E4A35_RS16925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4A35_RS16930	COG1733	regulation of RNA biosynthetic process
E4A35_RS16935	COG1733	regulation of RNA biosynthetic process
E4A35_RS16955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4A35_RS16975	COG0384	phenazine biosynthesis protein PhzF
E4A35_RS16985	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS16995	COG0318	PFAM AMP-dependent synthetase and ligase
E4A35_RS17000	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4A35_RS17005	COG1733	regulation of RNA biosynthetic process
E4A35_RS17025	COG1191	sigma factor activity
E4A35_RS17035	COG1266	CAAX protease self-immunity
E4A35_RS17040	COG1309	transcriptional regulator
E4A35_RS17060	COG3152	Membrane
E4A35_RS17085	COG1151	hydroxylamine reductase activity
E4A35_RS17095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4A35_RS17100	COG3757	hydrolase, family 25
E4A35_RS17100	COG3409	Peptidoglycan-binding domain 1 protein
E4A35_RS17125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4A35_RS17135	COG2072	flavoprotein involved in K transport
E4A35_RS17170	COG0604	alcohol dehydrogenase
E4A35_RS17175	COG1113	amino acid transport
E4A35_RS17180	COG2814	Major facilitator Superfamily
E4A35_RS17210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E4A35_RS17215	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4A35_RS17230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4A35_RS17235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4A35_RS17240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4A35_RS17245	COG3739	integral membrane protein
E4A35_RS17250	COG0384	phenazine biosynthesis protein PhzF
E4A35_RS17285	COG0583	DNA-binding transcription factor activity
E4A35_RS17305	COG1193	negative regulation of DNA recombination
E4A35_RS17320	COG2162	N-hydroxyarylamine O-acetyltransferase activity
E4A35_RS17325	COG1164	Oligoendopeptidase f
E4A35_RS17330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4A35_RS17360	COG0584	glycerophosphoryl diester phosphodiesterase
E4A35_RS17385	COG0640	Transcriptional regulator
E4A35_RS17390	COG0604	alcohol dehydrogenase
E4A35_RS17400	COG0457	Tetratricopeptide repeat
E4A35_RS17410	COG0385	Bile acid
E4A35_RS17415	COG0277	FAD linked oxidase domain protein
E4A35_RS17450	COG1216	Glycosyl transferase, family 2
E4A35_RS17455	COG1024	Enoyl-CoA hydratase
E4A35_RS17465	COG1285	pathogenesis
E4A35_RS17480	COG2514	catechol 2,3-dioxygenase activity
E4A35_RS17485	COG2720	vancomycin resistance protein
E4A35_RS17520	COG0716	FMN binding
E4A35_RS17550	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS17560	COG0165	Argininosuccinate lyase
E4A35_RS17575	COG4145	pantothenate transmembrane transporter activity
E4A35_RS17585	COG1012	belongs to the aldehyde dehydrogenase family
E4A35_RS17590	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS17600	COG1657	PFAM Prenyltransferase squalene oxidase
E4A35_RS17605	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
E4A35_RS17610	COG2962	Rard protein
E4A35_RS17615	COG3326	Membrane
E4A35_RS17630	COG0489	protein tyrosine kinase activity
E4A35_RS17640	COG0314	molybdopterin synthase activity
E4A35_RS17645	COG0303	'Molybdopterin
E4A35_RS17650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4A35_RS17655	COG2116	formate transmembrane transporter activity
E4A35_RS17665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4A35_RS17670	COG5609	conserved protein (DUF2294)
E4A35_RS17675	COG2427	Protein of unknown function (DUF1641)
E4A35_RS17680	COG3383	formate dehydrogenase (NAD+) activity
E4A35_RS17685	COG0697	spore germination
E4A35_RS17725	COG2226	methyltransferase
E4A35_RS17730	COG4166	transmembrane transport
E4A35_RS17735	COG4166	transmembrane transport
E4A35_RS17740	COG4166	transmembrane transport
E4A35_RS17745	COG1301	dicarboxylic acid transport
E4A35_RS17750	COG1316	TRANSCRIPTIONal
E4A35_RS17760	COG1595	DNA-templated transcription, initiation
E4A35_RS17770	COG1131	(ABC) transporter
E4A35_RS17780	COG0673	inositol 2-dehydrogenase activity
E4A35_RS17785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4A35_RS17790	COG0187	DNA topoisomerase II activity
E4A35_RS17795	COG1832	CoA-binding protein
E4A35_RS17800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4A35_RS17805	COG0745	RESPONSE REGULATOR receiver
E4A35_RS17825	COG4841	protein insertion into membrane
E4A35_RS17830	COG0824	Thioesterase
E4A35_RS17860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4A35_RS17870	COG1132	(ABC) transporter
E4A35_RS17875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4A35_RS17915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4A35_RS17930	COG0183	Belongs to the thiolase family
E4A35_RS17935	COG0318	PFAM AMP-dependent synthetase and ligase
E4A35_RS17940	COG1268	BioY protein
E4A35_RS17945	COG0318	PFAM AMP-dependent synthetase and ligase
E4A35_RS17960	COG1396	sequence-specific DNA binding
E4A35_RS18005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4A35_RS18015	COG5002	protein histidine kinase activity
E4A35_RS18020	COG0400	carboxylic ester hydrolase activity
E4A35_RS18025	COG0346	lactoylglutathione lyase activity
E4A35_RS18030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4A35_RS18035	COG0069	glutamate synthase activity
E4A35_RS18040	COG1902	pentaerythritol trinitrate reductase activity
E4A35_RS18045	COG1329	Transcriptional regulator
E4A35_RS18050	COG0010	Belongs to the arginase family
E4A35_RS18075	COG2226	methyltransferase
E4A35_RS18115	COG4846	Membrane protein involved in cytochrome C biogenesis
E4A35_RS18120	COG0785	Cytochrome C biogenesis protein
E4A35_RS18135	COG1473	amidohydrolase
E4A35_RS18145	COG1131	(ABC) transporter
E4A35_RS18155	COG0583	DNA-binding transcription factor activity
E4A35_RS18165	COG1346	cytolysis
E4A35_RS18180	COG0730	response to heat
E4A35_RS18205	COG1132	(ABC) transporter
E4A35_RS18210	COG1132	(ABC) transporter
E4A35_RS18265	COG0737	Belongs to the 5'-nucleotidase family
E4A35_RS18275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4A35_RS18295	COG1695	Transcriptional regulator
E4A35_RS18300	COG0174	glutamine synthetase
E4A35_RS18305	COG0789	Transcriptional regulator
E4A35_RS18310	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E4A35_RS18315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4A35_RS18320	COG2860	membrane
E4A35_RS18325	COG0464	growth
E4A35_RS18365	COG1388	LysM domain
E4A35_RS18365	COG3584	3D domain protein
E4A35_RS18370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4A35_RS18370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4A35_RS18370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4A35_RS18375	COG1105	Belongs to the carbohydrate kinase PfkB family
E4A35_RS18380	COG1349	DNA-binding transcription factor activity
E4A35_RS18385	COG1979	alcohol dehydrogenase
E4A35_RS18390	COG2322	membrane
E4A35_RS18400	COG1113	amino acid transport
E4A35_RS18420	COG1408	metallophosphoesterase
E4A35_RS18425	COG2116	formate transmembrane transporter activity
E4A35_RS18440	COG2217	Heavy metal translocating P-type atpase
E4A35_RS18445	COG2608	mercury ion transmembrane transporter activity
E4A35_RS18450	COG1937	Protein conserved in bacteria
E4A35_RS18460	COG2819	hydrolase of the alpha beta superfamily
E4A35_RS18465	COG1120	ATPase activity
E4A35_RS18470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4A35_RS18475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4A35_RS18480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4A35_RS18485	COG0708	Exodeoxyribonuclease III
E4A35_RS18490	COG2169	Transcriptional regulator
E4A35_RS18495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4A35_RS18500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E4A35_RS18510	COG2364	Membrane
E4A35_RS18525	COG2267	carboxylic ester hydrolase activity
E4A35_RS18530	COG0346	lactoylglutathione lyase activity
E4A35_RS18535	COG5001	Diguanylate cyclase
E4A35_RS18535	COG3300	MHYT domain
E4A35_RS18555	COG1346	cytolysis
E4A35_RS18560	COG1380	Effector of murein hydrolase LrgA
E4A35_RS18565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4A35_RS18570	COG0596	Alpha beta hydrolase
E4A35_RS18570	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4A35_RS18575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E4A35_RS18595	COG1404	Belongs to the peptidase S8 family
E4A35_RS18600	COG3773	Cell wall hydrolase
E4A35_RS18605	COG0562	UDP-galactopyranose mutase
E4A35_RS18615	COG1368	sulfuric ester hydrolase activity
E4A35_RS18620	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E4A35_RS18630	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
E4A35_RS18655	COG1131	(ABC) transporter
E4A35_RS18675	COG4550	Control of competence regulator ComK, YlbF/YmcA
E4A35_RS18685	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4A35_RS18690	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4A35_RS18690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4A35_RS18700	COG2359	stage V sporulation protein S
E4A35_RS18705	COG1692	metallophosphoesterase
E4A35_RS18730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4A35_RS18735	COG1426	Protein conserved in bacteria
E4A35_RS18750	COG0300	oxidoreductase activity
E4A35_RS18755	COG0612	Peptidase, M16
E4A35_RS18760	COG0612	Peptidase, M16
E4A35_RS18765	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4A35_RS18770	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4A35_RS18775	COG3845	ABC transporter
E4A35_RS18780	COG1744	ABC transporter substrate-binding protein PnrA-like
E4A35_RS18785	COG2188	Transcriptional regulator
E4A35_RS18790	COG1674	ftsk spoiiie
E4A35_RS18800	COG0740	serine-type endopeptidase activity
E4A35_RS18820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E4A35_RS18835	COG0527	aspartate kinase activity
E4A35_RS18840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4A35_RS18845	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4A35_RS18850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4A35_RS18855	COG1873	PFAM PRC-barrel domain
E4A35_RS18860	COG0612	Peptidase, M16
E4A35_RS18865	COG0726	polysaccharide deacetylase
E4A35_RS18880	COG0196	riboflavin kinase activity
E4A35_RS18895	COG1550	Protein conserved in bacteria
E4A35_RS18905	COG1358	cellular component organization or biogenesis
E4A35_RS18910	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E4A35_RS18915	COG0195	Participates in both transcription termination and antitermination
E4A35_RS18935	COG0750	zinc metalloprotease
E4A35_RS18945	COG4589	Belongs to the CDS family
E4A35_RS18960	COG0528	UMP kinase activity
E4A35_RS18990	COG4974	Belongs to the 'phage' integrase family
E4A35_RS19000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4A35_RS19005	COG0758	DNA mediated transformation
E4A35_RS19010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4A35_RS19050	COG1837	Belongs to the UPF0109 family
E4A35_RS19060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4A35_RS19070	COG0552	protein localization to endoplasmic reticulum
E4A35_RS19075	COG1196	nuclear chromosome segregation
E4A35_RS19085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4A35_RS19090	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS19095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4A35_RS19110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4A35_RS19115	COG1461	Dihydroxyacetone kinase
E4A35_RS19120	COG1302	Protein conserved in bacteria
E4A35_RS19135	COG1564	THIamine pyrophosphokinase
E4A35_RS19140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4A35_RS19145	COG1162	GTPase activity
E4A35_RS19150	COG0515	serine threonine protein kinase
E4A35_RS19150	COG2815	serine threonine protein kinase
E4A35_RS19155	COG0631	protein serine/threonine phosphatase activity
E4A35_RS19165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4A35_RS19165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4A35_RS19175	COG0242	peptide deformylase activity
E4A35_RS19180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4A35_RS19185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4A35_RS19205	COG1561	YicC-like family, N-terminal region
E4A35_RS19210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4A35_RS19220	COG0006	proline dipeptidase activity
E4A35_RS19240	COG3069	C4-dicarboxylate transmembrane transporter activity
E4A35_RS19300	COG0564	pseudouridine synthase activity
E4A35_RS19320	COG3599	regulation of cell shape
E4A35_RS19325	COG2302	S4 RNA-binding domain
E4A35_RS19330	COG0762	integral membrane protein
E4A35_RS19340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4A35_RS19345	COG1496	oxidoreductase activity
E4A35_RS19350	COG1873	PFAM PRC-barrel domain
E4A35_RS19355	COG1191	sigma factor activity
E4A35_RS19360	COG1191	sigma factor activity
E4A35_RS19370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4A35_RS19375	COG0849	cell division
E4A35_RS19380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4A35_RS19395	COG0772	Belongs to the SEDS family
E4A35_RS19410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4A35_RS19415	COG0768	penicillin binding
E4A35_RS19420	COG0768	penicillin binding
E4A35_RS19425	COG4839	cell division protein FtsL
E4A35_RS19440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4A35_RS19455	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4A35_RS19460	COG1399	metal-binding, possibly nucleic acid-binding protein
E4A35_RS19470	COG3480	Lon protease (S16) C-terminal proteolytic domain
E4A35_RS19475	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4A35_RS19480	COG3314	Sporulation integral membrane protein YlbJ
E4A35_RS19490	COG0742	ribosomal rna small subunit methyltransferase
E4A35_RS19505	COG3679	Belongs to the UPF0342 family
E4A35_RS19510	COG0406	alpha-ribazole phosphatase activity
E4A35_RS19525	COG2340	Cysteine-rich secretory protein family
E4A35_RS19540	COG3336	cytochrome c oxidase
E4A35_RS19575	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E4A35_RS19585	COG0772	Belongs to the SEDS family
E4A35_RS19595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4A35_RS19600	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4A35_RS19610	COG4896	Protein conserved in bacteria
E4A35_RS19625	COG1217	gtp-binding protein TYPA
E4A35_RS19630	COG0483	inositol monophosphate 1-phosphatase activity
E4A35_RS19650	COG1982	Orn Lys Arg decarboxylase major
E4A35_RS19700	COG0022	dehydrogenase e1 component
E4A35_RS19705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4A35_RS19715	COG0242	peptide deformylase activity
E4A35_RS19720	COG0561	phosphatase activity
E4A35_RS19735	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E4A35_RS19740	COG0569	domain protein
E4A35_RS19760	COG0583	DNA-binding transcription factor activity
E4A35_RS19765	COG0517	IMP dehydrogenase activity
E4A35_RS19775	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
E4A35_RS19780	COG4703	Protein of unknown function (DUF1797)
E4A35_RS19795	COG2200	EAL domain
E4A35_RS19800	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS19805	COG1408	metallophosphoesterase
E4A35_RS19820	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4A35_RS19855	COG2814	Major facilitator Superfamily
E4A35_RS19880	COG3209	COG3209 Rhs family protein
E4A35_RS19890	COG2205	protein histidine kinase activity
E4A35_RS19900	COG0436	Aminotransferase
E4A35_RS19905	COG1609	Transcriptional regulator
E4A35_RS19910	COG3833	ABC-type maltose transport systems, permease component
E4A35_RS19915	COG1175	transmembrane transport
E4A35_RS19920	COG2182	Extracellular solute-binding protein
E4A35_RS19930	COG0366	Alpha amylase catalytic
E4A35_RS19935	COG3842	ATPase activity
E4A35_RS19980	COG0183	Belongs to the thiolase family
E4A35_RS20020	COG1695	Transcriptional regulator
E4A35_RS20025	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS20045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4A35_RS20050	COG0436	Aminotransferase
E4A35_RS20085	COG2084	Dehydrogenase
E4A35_RS20090	COG2199	diguanylate cyclase activity
E4A35_RS20095	COG0778	Nitroreductase
E4A35_RS20120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4A35_RS20120	COG2190	(PTS) system
E4A35_RS20120	COG1263	PTS System
E4A35_RS20125	COG3711	transcriptional antiterminator
E4A35_RS20135	COG2188	Transcriptional regulator
E4A35_RS20145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4A35_RS20175	COG1547	Domain of unknown function (DUF309)
E4A35_RS20180	COG0456	acetyltransferase
E4A35_RS20190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4A35_RS20195	COG4086	secreted protein
E4A35_RS20200	COG0561	phosphatase activity
E4A35_RS20205	COG0697	spore germination
E4A35_RS20220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4A35_RS20245	COG0733	neurotransmitter:sodium symporter activity
E4A35_RS20265	COG1686	Belongs to the peptidase S11 family
E4A35_RS20275	COG1725	Transcriptional regulator
E4A35_RS20280	COG1131	(ABC) transporter
E4A35_RS20300	COG1846	Transcriptional regulator
E4A35_RS20315	COG0598	Magnesium transport protein CorA
E4A35_RS20340	COG4974	Belongs to the 'phage' integrase family
E4A35_RS20350	COG0735	belongs to the Fur family
E4A35_RS20355	COG1300	Membrane
E4A35_RS20375	COG0667	Aldo Keto reductase
E4A35_RS20380	COG0656	L-ascorbic acid biosynthetic process
E4A35_RS20385	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E4A35_RS20385	COG0456	acetyltransferase
E4A35_RS20395	COG1525	nuclease
E4A35_RS20395	COG0737	Belongs to the 5'-nucleotidase family
E4A35_RS20395	COG4085	toxin activity
E4A35_RS20405	COG0596	Alpha beta hydrolase
E4A35_RS20410	COG2056	Na+-H+ antiporter family
E4A35_RS20415	COG1609	Transcriptional regulator
E4A35_RS20420	COG0456	acetyltransferase
E4A35_RS20425	COG1073	alpha beta
E4A35_RS20440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4A35_RS20440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4A35_RS20445	COG0307	riboflavin synthase, alpha
E4A35_RS20470	COG4106	trans-aconitate 2-methyltransferase activity
E4A35_RS20475	COG2226	methyltransferase
E4A35_RS20475	COG1073	alpha beta
E4A35_RS20490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4A35_RS20500	COG1757	Na H antiporter
E4A35_RS20505	COG0737	Belongs to the 5'-nucleotidase family
E4A35_RS20515	COG1522	sequence-specific DNA binding
E4A35_RS20570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4A35_RS20595	COG0300	oxidoreductase activity
E4A35_RS20600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4A35_RS20605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4A35_RS20610	COG1760	l-serine dehydratase
E4A35_RS20615	COG1760	l-serine dehydratase
E4A35_RS20640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4A35_RS20650	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4A35_RS20655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4A35_RS20665	COG1376	ErfK ybiS ycfS ynhG family protein
E4A35_RS20670	COG4129	membrane
E4A35_RS20675	COG1126	abc transporter atp-binding protein
E4A35_RS20680	COG0765	amino acid transport
E4A35_RS20685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4A35_RS20695	COG2816	NAD+ diphosphatase activity
E4A35_RS20700	COG0772	Belongs to the SEDS family
E4A35_RS20710	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4A35_RS20715	COG0022	dehydrogenase e1 component
E4A35_RS20720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4A35_RS20725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4A35_RS20740	COG0280	phosphate acetyltransferase
E4A35_RS20750	COG3290	protein histidine kinase activity
E4A35_RS20750	COG3829	transcription factor binding
E4A35_RS20760	COG0584	glycerophosphoryl diester phosphodiesterase
E4A35_RS20765	COG3093	addiction module antidote protein HigA
E4A35_RS20775	COG0745	RESPONSE REGULATOR receiver
E4A35_RS20785	COG0750	zinc metalloprotease
E4A35_RS20790	COG0497	DNA recombination
E4A35_RS20800	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E4A35_RS20810	COG0142	geranyltranstransferase activity
E4A35_RS20835	COG1302	Protein conserved in bacteria
E4A35_RS20840	COG0439	Biotin carboxylase
E4A35_RS20845	COG0511	ligase activity, forming carbon-carbon bonds
E4A35_RS20890	COG3854	ATPases associated with a variety of cellular activities
E4A35_RS20915	COG0006	proline dipeptidase activity
E4A35_RS20930	COG3872	metal-dependent enzyme
E4A35_RS20940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4A35_RS20975	COG0095	Lipoate-protein ligase
E4A35_RS20980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4A35_RS20985	COG1609	Transcriptional regulator
E4A35_RS20995	COG2076	Multidrug Resistance protein
E4A35_RS21000	COG2076	Multidrug Resistance protein
E4A35_RS21040	COG1725	Transcriptional regulator
E4A35_RS21075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4A35_RS21135	COG4970	Tfp pilus assembly protein FimT
E4A35_RS21185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4A35_RS21185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4A35_RS21210	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4A35_RS21235	COG1459	type II secretion system
E4A35_RS21240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4A35_RS21290	COG0646	methionine synthase
E4A35_RS21290	COG1410	methionine synthase
E4A35_RS21295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4A35_RS21295	COG0646	methionine synthase
E4A35_RS21300	COG0626	cystathionine gamma-synthase activity
E4A35_RS21305	COG0626	cystathionine gamma-synthase activity
E4A35_RS21325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4A35_RS21335	COG1940	carbohydrate kinase activity
E4A35_RS21340	COG4483	Protein conserved in bacteria
E4A35_RS21345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4A35_RS21350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4A35_RS21355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4A35_RS21360	COG0704	Plays a role in the regulation of phosphate uptake
E4A35_RS21370	COG0581	inorganic phosphate transmembrane transporter activity
E4A35_RS21375	COG0573	inorganic phosphate transmembrane transporter activity
E4A35_RS21380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4A35_RS21385	COG0768	penicillin binding
E4A35_RS21390	COG0477	Major facilitator Superfamily
E4A35_RS21395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4A35_RS21420	COG0735	belongs to the Fur family
E4A35_RS21425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4A35_RS21430	COG1121	(ABC) transporter
E4A35_RS21435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4A35_RS21465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4A35_RS21470	COG2384	SAM-dependent methyltransferase
E4A35_RS21475	COG2010	Cytochrome c
E4A35_RS21480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4A35_RS21485	COG0358	DNA primase activity
E4A35_RS21495	COG0517	IMP dehydrogenase activity
E4A35_RS21510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4A35_RS21515	COG0295	cytidine deaminase activity
E4A35_RS21520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4A35_RS21530	COG1480	7TM receptor with intracellular HD hydrolase
E4A35_RS21535	COG1702	phosphate starvation-inducible protein PhoH
E4A35_RS21550	COG1610	YqeY-like protein
E4A35_RS21555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4A35_RS21565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4A35_RS21570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4A35_RS21600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4A35_RS21605	COG1733	regulation of RNA biosynthetic process
E4A35_RS21630	COG1466	dna polymerase III delta subunit
E4A35_RS21640	COG0658	competence protein
E4A35_RS21640	COG2333	competence protein COMEC
E4A35_RS21645	COG2131	deaminase
E4A35_RS21650	COG1596	polysaccharide export
E4A35_RS21650	COG1555	photosystem II stabilization
E4A35_RS21655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4A35_RS21660	COG2226	methyltransferase
E4A35_RS21665	COG0799	negative regulation of ribosome biogenesis
E4A35_RS21670	COG1713	HD superfamily hydrolase involved in NAD metabolism
E4A35_RS21680	COG1534	Rna-binding protein
E4A35_RS21690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4A35_RS21695	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E4A35_RS21720	COG1595	DNA-templated transcription, initiation
E4A35_RS21730	COG0778	Nitroreductase
E4A35_RS21735	COG2357	RelA SpoT domain protein
E4A35_RS21745	COG1785	Belongs to the alkaline phosphatase family
E4A35_RS21755	COG2267	carboxylic ester hydrolase activity
E4A35_RS21790	COG1404	Belongs to the peptidase S8 family
E4A35_RS21795	COG3186	Phenylalanine-4-hydroxylase
E4A35_RS21805	COG2514	catechol 2,3-dioxygenase activity
E4A35_RS21810	COG2259	Doxx family
E4A35_RS21850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4A35_RS21860	COG1012	belongs to the aldehyde dehydrogenase family
E4A35_RS21860	COG1454	alcohol dehydrogenase
E4A35_RS21865	COG0626	cystathionine gamma-synthase activity
E4A35_RS21870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4A35_RS21895	COG0768	penicillin binding
E4A35_RS21910	COG0826	peptidase U32
E4A35_RS21915	COG0826	peptidase U32
E4A35_RS21920	COG4122	O-methyltransferase activity
E4A35_RS21925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4A35_RS21955	COG0628	permease
E4A35_RS21975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4A35_RS21990	COG1104	cysteine desulfurase activity
E4A35_RS21995	COG1959	2 iron, 2 sulfur cluster binding
E4A35_RS22000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4A35_RS22015	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4A35_RS22035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4A35_RS22045	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4A35_RS22045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4A35_RS22050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4A35_RS22055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4A35_RS22055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4A35_RS22065	COG2244	polysaccharide biosynthetic process
E4A35_RS22070	COG2323	membrane
E4A35_RS22080	COG1862	Preprotein translocase
E4A35_RS22110	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E4A35_RS22120	COG0697	spore germination
E4A35_RS22125	COG0640	Transcriptional regulator
E4A35_RS22150	COG0157	Belongs to the NadC ModD family
E4A35_RS22155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4A35_RS22160	COG1104	cysteine desulfurase activity
E4A35_RS22165	COG1827	regulation of RNA biosynthetic process
E4A35_RS22170	COG2258	MOSC domain
E4A35_RS22175	COG0077	Prephenate dehydratase
E4A35_RS22180	COG0577	efflux transmembrane transporter activity
E4A35_RS22185	COG0577	efflux transmembrane transporter activity
E4A35_RS22190	COG1136	(ABC) transporter
E4A35_RS22195	COG5002	protein histidine kinase activity
E4A35_RS22200	COG0745	RESPONSE REGULATOR receiver
E4A35_RS22210	COG3290	protein histidine kinase activity
E4A35_RS22220	COG2868	ribosomal protein
E4A35_RS22230	COG1530	ribonuclease E activity
E4A35_RS22235	COG1994	Peptidase M50
E4A35_RS22240	COG0739	heme binding
E4A35_RS22245	COG2894	cell division
E4A35_RS22265	COG1077	Cell shape determining protein MreB Mrl
E4A35_RS22290	COG0285	dihydrofolate synthase activity
E4A35_RS22295	COG0525	valine-tRNA ligase activity
E4A35_RS22305	COG1388	LysM domain
E4A35_RS22315	COG0113	porphobilinogen synthase activity
E4A35_RS22320	COG1587	Uroporphyrinogen-III synthase
E4A35_RS22330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4A35_RS22340	COG1846	Transcriptional regulator
E4A35_RS22345	COG1764	response to oxidative stress
E4A35_RS22360	COG0470	DNA polymerase III
E4A35_RS22360	COG1067	ATP-dependent peptidase activity
E4A35_RS22410	COG0622	Phosphoesterase
E4A35_RS22425	COG5401	PFAM Sporulation and spore germination
E4A35_RS22440	COG2197	response regulator
E4A35_RS22445	COG2233	PERMEase
E4A35_RS22450	COG0402	S-adenosylhomocysteine deaminase activity
E4A35_RS22460	COG1396	sequence-specific DNA binding
E4A35_RS22465	COG0697	spore germination
E4A35_RS22475	COG1959	2 iron, 2 sulfur cluster binding
E4A35_RS22480	COG1668	transmembrane transport
E4A35_RS22485	COG4152	abc transporter atp-binding protein
E4A35_RS22490	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
E4A35_RS22495	COG1360	Flagellar Motor Protein
E4A35_RS22500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4A35_RS22505	COG1876	peptidase activity
E4A35_RS22510	COG0824	Thioesterase
E4A35_RS22515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4A35_RS22520	COG1053	succinate dehydrogenase
E4A35_RS22525	COG2009	succinate dehydrogenase
E4A35_RS22530	COG1719	4-vinyl reductase, 4VR
E4A35_RS22540	COG3118	belongs to the thioredoxin family
E4A35_RS22545	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4A35_RS22550	COG2086	electron transfer activity
E4A35_RS22555	COG1024	Enoyl-CoA hydratase
E4A35_RS22560	COG1309	transcriptional regulator
E4A35_RS22565	COG0318	PFAM AMP-dependent synthetase and ligase
E4A35_RS22585	COG2318	DinB family
E4A35_RS22605	COG1131	(ABC) transporter
E4A35_RS22610	COG2205	protein histidine kinase activity
E4A35_RS22615	COG0745	RESPONSE REGULATOR receiver
E4A35_RS22620	COG4895	conserved protein (DUF2196)
E4A35_RS22625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4A35_RS22640	COG4509	Sortase family
E4A35_RS22645	COG1120	ATPase activity
E4A35_RS22660	COG5386	Cell surface protein
E4A35_RS22665	COG5386	Cell surface protein
E4A35_RS22670	COG1114	Component of the transport system for branched-chain amino acids
E4A35_RS22675	COG1187	pseudouridine synthase activity
E4A35_RS22685	COG1796	DNA polymerase
E4A35_RS22685	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4A35_RS22690	COG1286	toxin biosynthetic process
E4A35_RS22735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4A35_RS22745	COG1418	mRNA catabolic process
E4A35_RS22755	COG2814	Major facilitator Superfamily
E4A35_RS22760	COG1566	PFAM secretion protein HlyD family protein
E4A35_RS22765	COG1309	transcriptional regulator
E4A35_RS22770	COG1363	Peptidase, m42
E4A35_RS22795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4A35_RS22805	COG1484	DNA-dependent DNA replication
E4A35_RS22810	COG3611	Membrane attachment protein
E4A35_RS22820	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E4A35_RS22825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4A35_RS22830	COG0237	dephospho-CoA kinase activity
E4A35_RS22835	COG1971	Probably functions as a manganese efflux pump
E4A35_RS22845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4A35_RS22845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4A35_RS22850	COG5002	protein histidine kinase activity
E4A35_RS22855	COG0745	RESPONSE REGULATOR receiver
E4A35_RS22870	COG0538	isocitrate dehydrogenase activity
E4A35_RS22875	COG0372	Belongs to the citrate synthase family
E4A35_RS22890	COG0628	permease
E4A35_RS22895	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4A35_RS22920	COG1725	Transcriptional regulator
E4A35_RS22925	COG0281	malic enzyme
E4A35_RS22930	COG0587	DNA-directed DNA polymerase activity
E4A35_RS22945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4A35_RS22965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4A35_RS22975	COG4109	DRTGG domain
E4A35_RS22985	COG0006	proline dipeptidase activity
E4A35_RS23030	COG0662	Cupin 2, conserved barrel domain protein
E4A35_RS23045	COG1028	Short-chain dehydrogenase reductase Sdr
E4A35_RS23050	COG0589	response to stress
E4A35_RS23090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4A35_RS23110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4A35_RS23115	COG0827	DNA restriction-modification system
E4A35_RS23120	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E4A35_RS23125	COG3874	Sporulation protein YtfJ
E4A35_RS23140	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E4A35_RS23150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4A35_RS23165	COG1104	cysteine desulfurase activity
E4A35_RS23175	COG0583	DNA-binding transcription factor activity
E4A35_RS23180	COG0697	spore germination
E4A35_RS23185	COG1309	transcriptional regulator
E4A35_RS23190	COG1956	GAF domain-containing protein
E4A35_RS23240	COG1595	DNA-templated transcription, initiation
E4A35_RS23250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4A35_RS23255	COG0454	-acetyltransferase
E4A35_RS23260	COG0517	IMP dehydrogenase activity
E4A35_RS23265	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4A35_RS23280	COG0745	RESPONSE REGULATOR receiver
E4A35_RS23290	COG0666	response to abiotic stimulus
E4A35_RS23325	COG1609	Transcriptional regulator
E4A35_RS23340	COG4851	CamS sex pheromone cAM373 precursor
E4A35_RS23345	COG3118	belongs to the thioredoxin family
E4A35_RS23355	COG2309	aminopeptidase activity
E4A35_RS23375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4A35_RS23380	COG1695	Transcriptional regulator
E4A35_RS23400	COG1674	ftsk spoiiie
E4A35_RS23410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4A35_RS23420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4A35_RS23425	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
E4A35_RS23430	COG1363	Peptidase, m42
E4A35_RS23440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4A35_RS23455	COG0510	thiamine kinase activity
E4A35_RS23460	COG1523	belongs to the glycosyl hydrolase 13 family
E4A35_RS23470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4A35_RS23475	COG1349	DNA-binding transcription factor activity
E4A35_RS23480	COG1187	pseudouridine synthase activity
E4A35_RS23485	COG2244	polysaccharide biosynthetic process
E4A35_RS23490	COG2081	HI0933 family
E4A35_RS23495	COG2814	Major facilitator Superfamily
E4A35_RS23505	COG3832	glyoxalase III activity
E4A35_RS23530	COG1329	Transcriptional regulator
E4A35_RS23555	COG0314	molybdopterin synthase activity
E4A35_RS23560	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4A35_RS23565	COG0303	'Molybdopterin
E4A35_RS23575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4A35_RS23580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4A35_RS23600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4A35_RS23610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4A35_RS23650	COG2814	Major facilitator Superfamily
E4A35_RS23655	COG0475	glutathione-regulated potassium exporter activity
E4A35_RS23660	COG0490	domain, Protein
E4A35_RS23665	COG0582	viral genome integration into host DNA
E4A35_RS23675	COG1136	(ABC) transporter
E4A35_RS23695	COG1242	4 iron, 4 sulfur cluster binding
E4A35_RS23700	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E4A35_RS23715	COG1794	racemase activity, acting on amino acids and derivatives
E4A35_RS23725	COG5504	Zn-dependent protease
E4A35_RS23755	COG2267	carboxylic ester hydrolase activity
E4A35_RS23760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4A35_RS23765	COG0671	phosphoesterase, PA-phosphatase related
E4A35_RS23770	COG0438	transferase activity, transferring glycosyl groups
E4A35_RS23845	COG5002	protein histidine kinase activity
E4A35_RS23850	COG4191	Histidine kinase
E4A35_RS23855	COG2267	carboxylic ester hydrolase activity
E4A35_RS23860	COG1368	sulfuric ester hydrolase activity
E4A35_RS23875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4A35_RS23880	COG1116	anion transmembrane transporter activity
E4A35_RS23885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4A35_RS23900	COG0546	phosphoglycolate phosphatase activity
E4A35_RS23910	COG0494	nUDIX hydrolase
E4A35_RS23945	COG0288	reversible hydration of carbon dioxide
E4A35_RS23950	COG1271	oxidase subunit
E4A35_RS23955	COG1294	oxidase, subunit
E4A35_RS23975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4A35_RS24000	COG1842	Phage shock protein A
E4A35_RS24045	COG5002	protein histidine kinase activity
E4A35_RS24050	COG0745	RESPONSE REGULATOR receiver
E4A35_RS24080	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4A35_RS24085	COG1597	lipid kinase activity
E4A35_RS24100	COG0577	efflux transmembrane transporter activity
E4A35_RS24105	COG1136	(ABC) transporter
E4A35_RS24120	COG0586	Pfam SNARE associated Golgi protein
E4A35_RS24130	COG4977	sequence-specific DNA binding
E4A35_RS24140	COG0577	efflux transmembrane transporter activity
E4A35_RS24145	COG1136	(ABC) transporter
E4A35_RS24150	COG2207	Transcriptional regulator
E4A35_RS24150	COG3708	Transcriptional regulator
E4A35_RS24155	COG0745	RESPONSE REGULATOR receiver
E4A35_RS24160	COG2205	protein histidine kinase activity
E4A35_RS24165	COG0577	efflux transmembrane transporter activity
E4A35_RS24170	COG0577	efflux transmembrane transporter activity
E4A35_RS24175	COG1136	(ABC) transporter
E4A35_RS24180	COG0577	efflux transmembrane transporter activity
E4A35_RS24195	COG2188	Transcriptional regulator
E4A35_RS24215	COG3964	amidohydrolase
E4A35_RS24235	COG4948	Mandelate Racemase Muconate Lactonizing
E4A35_RS24245	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4A35_RS24250	COG0596	Alpha beta hydrolase
E4A35_RS24260	COG1169	isochorismate synthase
E4A35_RS24265	COG1575	Belongs to the MenA family. Type 1 subfamily
E4A35_RS24270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4A35_RS24290	COG0058	SHG alpha-glucan phosphorylase activity
E4A35_RS24300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4A35_RS24430	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4A35_RS24465	COG1285	pathogenesis
E4A35_RS24470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4A35_RS24490	COG2155	Conserved Protein
E4A35_RS24495	COG1098	S1 RNA binding domain
E4A35_RS24500	COG0436	Aminotransferase
E4A35_RS24505	COG1522	sequence-specific DNA binding
E4A35_RS24510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4A35_RS24515	COG2267	carboxylic ester hydrolase activity
E4A35_RS24525	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4A35_RS24540	COG5018	Exonuclease
E4A35_RS24545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4A35_RS24565	COG2050	protein possibly involved in aromatic compounds catabolism
E4A35_RS24575	COG1268	BioY protein
E4A35_RS24585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4A35_RS24590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4A35_RS24605	COG3584	3D domain protein
E4A35_RS24620	COG1252	NADH dehydrogenase
E4A35_RS24635	COG3708	Transcriptional regulator
E4A35_RS24650	COG1683	Conserved Protein
E4A35_RS24670	COG0316	Belongs to the HesB IscA family
E4A35_RS24685	COG1252	NADH dehydrogenase
E4A35_RS24700	COG0390	transport system, permease component
E4A35_RS24710	COG2824	Alkylphosphonate utilization operon protein PhnA
E4A35_RS24730	COG4837	Protein of unknown function (DUF1462)
E4A35_RS24735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4A35_RS24745	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4A35_RS24750	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4A35_RS24765	COG1136	(ABC) transporter
E4A35_RS24765	COG0577	efflux transmembrane transporter activity
E4A35_RS24770	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4A35_RS24780	COG0647	UMP catabolic process
E4A35_RS24790	COG2445	Protein of unknown function DUF86
E4A35_RS24795	COG1494	fructose-1,6-bisphosphatase
E4A35_RS24815	COG4470	Protein conserved in bacteria
E4A35_RS24825	COG0789	Transcriptional regulator
E4A35_RS24830	COG4377	Putative membrane peptidase family (DUF2324)
E4A35_RS24855	COG0739	heme binding
E4A35_RS24865	COG3377	Domain of unknown function (DUF1805)
E4A35_RS24870	COG0737	Belongs to the 5'-nucleotidase family
E4A35_RS24880	COG0719	Fe-S assembly protein
E4A35_RS24885	COG0822	iron-sulfur transferase activity
E4A35_RS24890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4A35_RS24895	COG0719	Fe-S assembly protein
E4A35_RS24900	COG0396	ATPase activity
E4A35_RS24905	COG1464	Belongs to the NlpA lipoprotein family
E4A35_RS24910	COG1464	Belongs to the NlpA lipoprotein family
E4A35_RS24915	COG2011	ABC-type metal ion transport system permease component
E4A35_RS24930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4A35_RS24935	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E4A35_RS24945	COG1393	Belongs to the ArsC family
E4A35_RS25020	COG1396	sequence-specific DNA binding
E4A35_RS25030	COG1309	transcriptional regulator
E4A35_RS25035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4A35_RS25040	COG1960	acyl-CoA dehydrogenase activity
E4A35_RS25045	COG0183	Belongs to the thiolase family
E4A35_RS25050	COG1024	Enoyl-CoA hydratase
E4A35_RS25050	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4A35_RS25060	COG1686	Belongs to the peptidase S11 family
E4A35_RS25075	COG0011	TIGRFAM Protein of
E4A35_RS25080	COG0840	transmembrane signaling receptor activity
E4A35_RS25100	COG0531	amino acid
E4A35_RS25110	COG0706	membrane insertase activity
E4A35_RS25120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4A35_RS25160	COG0586	Pfam SNARE associated Golgi protein
E4A35_RS25170	COG1376	ErfK ybiS ycfS ynhG family protein
E4A35_RS25175	COG0745	RESPONSE REGULATOR receiver
E4A35_RS25180	COG5002	protein histidine kinase activity
E4A35_RS25205	COG0840	transmembrane signaling receptor activity
E4A35_RS25210	COG2151	metal-sulfur cluster biosynthetic enzyme
E4A35_RS25215	COG3227	Zinc metalloprotease (Elastase)
E4A35_RS25220	COG1741	Belongs to the pirin family
E4A35_RS25235	COG0475	glutathione-regulated potassium exporter activity
E4A35_RS25240	COG0490	domain, Protein
E4A35_RS25245	COG1115	amino acid carrier protein
E4A35_RS25250	COG0783	Belongs to the Dps family
E4A35_RS25265	COG1611	Belongs to the LOG family
E4A35_RS25285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4A35_RS25290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4A35_RS25295	COG1115	amino acid carrier protein
E4A35_RS25300	COG2910	NAD(P)H-binding
E4A35_RS25320	COG0656	L-ascorbic acid biosynthetic process
E4A35_RS25325	COG2814	Major facilitator Superfamily
E4A35_RS25330	COG1733	regulation of RNA biosynthetic process
E4A35_RS25340	COG1252	NADH dehydrogenase
E4A35_RS25345	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4A35_RS25360	COG3290	protein histidine kinase activity
E4A35_RS25360	COG0840	transmembrane signaling receptor activity
E4A35_RS25370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4A35_RS25390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4A35_RS25455	COG0557	exoribonuclease II activity
E4A35_RS25460	COG1647	Serine aminopeptidase, S33
E4A35_RS25465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4A35_RS25470	COG1346	cytolysis
E4A35_RS25505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4A35_RS25520	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4A35_RS25540	COG0457	Tetratricopeptide repeat
E4A35_RS25570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4A35_RS25585	COG2323	membrane
E4A35_RS25600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4A35_RS25610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4A35_RS25620	COG1051	belongs to the nudix hydrolase family
E4A35_RS25630	COG0492	ferredoxin-NADP+ reductase activity
E4A35_RS25635	COG0457	Tetratricopeptide repeat
E4A35_RS25640	COG0110	maltose O-acetyltransferase activity
E4A35_RS25660	COG1950	PFAM Membrane protein of
E4A35_RS25670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4A35_RS25690	COG0789	Transcriptional regulator
E4A35_RS25720	COG2855	membrane
E4A35_RS25725	COG0583	DNA-binding transcription factor activity
E4A35_RS25735	COG0655	NAD(P)H dehydrogenase (quinone) activity
E4A35_RS25740	COG0488	(ABC) transporter
E4A35_RS25750	COG1132	(ABC) transporter
E4A35_RS25755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4A35_RS25760	COG0793	Belongs to the peptidase S41A family
E4A35_RS25760	COG3409	Peptidoglycan-binding domain 1 protein
E4A35_RS25765	COG2177	Part of the ABC transporter FtsEX involved in
E4A35_RS25770	COG2884	Cell division ATP-binding protein ftsE
E4A35_RS25790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4A35_RS25795	COG1278	Cold shock
E4A35_RS25800	COG1040	competence protein
E4A35_RS25805	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E4A35_RS25810	COG0791	NLP P60 protein
E4A35_RS25810	COG1388	LysM domain
E4A35_RS25815	COG1733	regulation of RNA biosynthetic process
E4A35_RS25820	COG1307	EDD domain protein, DegV family
E4A35_RS25825	COG1739	Uncharacterized protein family UPF0029
E4A35_RS25830	COG1316	TRANSCRIPTIONal
E4A35_RS25835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4A35_RS25840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4A35_RS25845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4A35_RS25855	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4A35_RS25855	COG3933	PFAM sigma-54 factor interaction domain-containing protein
E4A35_RS25870	COG3394	polysaccharide catabolic process
E4A35_RS25875	COG1486	melibiose metabolic process
E4A35_RS25880	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4A35_RS25885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4A35_RS25895	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E4A35_RS25900	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E4A35_RS25905	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4A35_RS25915	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4A35_RS25920	COG1301	dicarboxylic acid transport
E4A35_RS25930	COG0346	lactoylglutathione lyase activity
E4A35_RS25935	COG1511	domain protein
E4A35_RS25940	COG0583	DNA-binding transcription factor activity
E4A35_RS25945	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E4A35_RS25950	COG1271	oxidase subunit
E4A35_RS25955	COG1294	oxidase, subunit
E4A35_RS25960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4A35_RS25970	COG1620	l-lactate permease
E4A35_RS25980	COG2389	metal-binding protein
E4A35_RS25995	COG1368	sulfuric ester hydrolase activity
E4A35_RS26005	COG1388	LysM domain
E4A35_RS26005	COG0791	NLP P60 protein
E4A35_RS26010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4A35_RS26020	COG1215	transferase activity, transferring glycosyl groups
E4A35_RS26025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4A35_RS26035	COG3584	3D domain protein
E4A35_RS26035	COG1388	LysM domain
E4A35_RS26060	COG4715	Zinc finger, swim domain protein
E4A35_RS26065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4A35_RS26110	COG0577	efflux transmembrane transporter activity
E4A35_RS26115	COG1136	(ABC) transporter
E4A35_RS26150	COG5002	protein histidine kinase activity
E4A35_RS26155	COG0745	RESPONSE REGULATOR receiver
E4A35_RS26160	COG1482	cell wall glycoprotein biosynthetic process
E4A35_RS26165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4A35_RS26165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4A35_RS26165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4A35_RS26170	COG3711	transcriptional antiterminator
E4A35_RS26170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4A35_RS26175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4A35_RS26190	COG1482	cell wall glycoprotein biosynthetic process
E4A35_RS26200	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4A35_RS26200	COG0662	Cupin 2, conserved barrel domain protein
E4A35_RS26205	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4A35_RS26215	COG0110	maltose O-acetyltransferase activity
E4A35_RS26245	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4A35_RS26250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4A35_RS26255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4A35_RS26260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4A35_RS26265	COG4464	protein tyrosine phosphatase activity
E4A35_RS26270	COG0489	protein tyrosine kinase activity
E4A35_RS26275	COG3944	biosynthesis protein
E4A35_RS26280	COG0489	protein tyrosine kinase activity
E4A35_RS26295	COG1609	Transcriptional regulator
E4A35_RS26305	COG0739	heme binding
E4A35_RS26320	COG3279	Response regulator of the LytR AlgR family
E4A35_RS26325	COG2385	sporulation resulting in formation of a cellular spore
E4A35_RS26340	COG4836	Membrane
E4A35_RS26345	COG1007	ATP synthesis coupled electron transport
E4A35_RS26350	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4A35_RS26355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4A35_RS26365	COG0839	Belongs to the complex I subunit 6 family
E4A35_RS26385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4A35_RS26400	COG5001	Diguanylate cyclase
E4A35_RS26400	COG3300	MHYT domain
E4A35_RS26450	COG0356	it plays a direct role in the translocation of protons across the membrane
E4A35_RS26485	COG0698	ribose 5-phosphate isomerase
E4A35_RS26495	COG2190	(PTS) system
E4A35_RS26500	COG2259	Doxx family
E4A35_RS26505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4A35_RS26525	COG0009	L-threonylcarbamoyladenylate synthase
E4A35_RS26540	COG2890	protein-(glutamine-N5) methyltransferase activity
E4A35_RS26565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4A35_RS26570	COG1494	fructose-1,6-bisphosphatase
E4A35_RS26590	COG4821	SIS domain
E4A35_RS26610	COG1960	acyl-CoA dehydrogenase activity
E4A35_RS26615	COG1960	acyl-CoA dehydrogenase activity
E4A35_RS26620	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4A35_RS26625	COG0183	Belongs to the thiolase family
E4A35_RS26630	COG0247	lactate metabolic process
E4A35_RS26630	COG2181	nitrate reductase activity
E4A35_RS26635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4A35_RS26645	COG3300	MHYT domain
E4A35_RS26645	COG5001	Diguanylate cyclase
E4A35_RS26665	COG2197	response regulator
E4A35_RS26670	COG4585	Histidine kinase
E4A35_RS26675	COG0842	Transport permease protein
E4A35_RS26680	COG1131	(ABC) transporter
E4A35_RS26685	COG0024	Methionine aminopeptidase
E4A35_RS26695	COG2234	aminopeptidase activity
E4A35_RS26715	COG1595	DNA-templated transcription, initiation
E4A35_RS26725	COG4506	Protein conserved in bacteria
E4A35_RS26730	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4A35_RS26745	COG0010	Belongs to the arginase family
E4A35_RS26755	COG2814	Major facilitator Superfamily
E4A35_RS26760	COG0789	Transcriptional regulator
E4A35_RS26765	COG0584	glycerophosphoryl diester phosphodiesterase
E4A35_RS26770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4A35_RS26780	COG1994	Peptidase M50
E4A35_RS26790	COG1078	dGTPase activity
E4A35_RS26795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4A35_RS26800	COG1120	ATPase activity
E4A35_RS26805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4A35_RS26810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4A35_RS26830	COG0095	Lipoate-protein ligase
E4A35_RS26835	COG0280	phosphate acetyltransferase
E4A35_RS26850	COG3773	Cell wall hydrolase
E4A35_RS26860	COG2363	Small membrane protein
E4A35_RS26870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4A35_RS26875	COG2233	PERMEase
E4A35_RS26880	COG0561	phosphatase activity
E4A35_RS26885	COG2814	Major facilitator Superfamily
E4A35_RS26895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4A35_RS26900	COG1131	(ABC) transporter
E4A35_RS26905	COG2755	lipolytic protein G-D-S-L family
E4A35_RS26910	COG1609	Transcriptional regulator
E4A35_RS26920	COG0460	homoserine dehydrogenase
E4A35_RS26930	COG2873	o-acetylhomoserine
E4A35_RS26940	COG1011	Hydrolase
E4A35_RS26945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4A35_RS26955	COG2197	response regulator
E4A35_RS26960	COG4585	Histidine kinase
E4A35_RS26960	COG2203	Gaf domain
E4A35_RS26965	COG0351	phosphomethylpyrimidine kinase
E4A35_RS26970	COG3706	GGDEF domain
E4A35_RS26975	COG2879	small protein
E4A35_RS26980	COG1966	Carbon starvation protein
E4A35_RS26985	COG3279	Response regulator of the LytR AlgR family
E4A35_RS26990	COG0477	Major facilitator Superfamily
E4A35_RS27015	COG0840	transmembrane signaling receptor activity
E4A35_RS27025	COG1607	acyl-coa hydrolase
E4A35_RS27030	COG1216	Glycosyl transferase, family 2
E4A35_RS27040	COG0488	(ABC) transporter
E4A35_RS27060	COG0463	Glycosyl transferase, family 2
E4A35_RS27065	COG1309	transcriptional regulator
E4A35_RS27070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4A35_RS27075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4A35_RS27075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4A35_RS27080	COG0628	permease
E4A35_RS27095	COG3279	Response regulator of the LytR AlgR family
E4A35_RS27100	COG3275	phosphorelay sensor kinase activity
E4A35_RS27105	COG2814	Major facilitator Superfamily
E4A35_RS27110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4A35_RS27115	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
E4A35_RS27125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4A35_RS27145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4A35_RS27150	COG1272	protein, Hemolysin III
E4A35_RS27180	COG1164	Oligoendopeptidase f
E4A35_RS27200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4A35_RS27205	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4A35_RS27210	COG4853	Protein conserved in bacteria
E4A35_RS27215	COG4863	YycH protein
E4A35_RS27220	COG5002	protein histidine kinase activity
E4A35_RS27225	COG0745	RESPONSE REGULATOR receiver
E4A35_RS27255	COG0305	Participates in initiation and elongation during chromosome replication
E4A35_RS27265	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E4A35_RS27270	COG4241	membrane
E4A35_RS27280	COG0629	single-stranded DNA binding
E4A35_RS27290	COG0012	GTP binding
E4A35_RS27295	COG4481	Protein conserved in bacteria
E4A35_RS27300	COG0668	transmembrane transport
E4A35_RS27310	COG1475	DNA binding
E4A35_RS27315	COG1192	Involved in chromosome partitioning
E4A35_RS27340	COG1847	R3H domain protein
E4A35_RS27345	COG0706	membrane insertase activity
E4A35_RS27355	COG0230	Belongs to the bacterial ribosomal protein bL34 family