locus-tag	class	description
L6489_RS00010	COG0592	DNA-directed DNA polymerase activity
L6489_RS00015	COG2501	S4 domain
L6489_RS00025	COG0187	DNA topoisomerase II activity
L6489_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6489_RS00065	COG0516	GMP reductase activity
L6489_RS00065	COG0517	IMP dehydrogenase activity
L6489_RS00070	COG1686	Belongs to the peptidase S11 family
L6489_RS00100	COG1428	Deoxynucleoside kinase
L6489_RS00105	COG1428	Deoxynucleoside kinase
L6489_RS00110	COG1335	isochorismatase
L6489_RS00115	COG0590	tRNA wobble adenosine to inosine editing
L6489_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L6489_RS00180	COG1982	Orn Lys Arg decarboxylase major
L6489_RS00190	COG0470	DNA polymerase III
L6489_RS00195	COG1774	PSP1 C-terminal conserved region
L6489_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L6489_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L6489_RS00220	COG2002	toxin-antitoxin pair type II binding
L6489_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6489_RS00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6489_RS00230	COG0084	hydrolase, TatD family'
L6489_RS00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6489_RS00250	COG4466	Protein conserved in bacteria
L6489_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L6489_RS00270	COG0251	oxidation-reduction process
L6489_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L6489_RS00305	COG2002	toxin-antitoxin pair type II binding
L6489_RS00310	COG2244	polysaccharide biosynthetic process
L6489_RS00315	COG3956	TIGRFAM MazG family protein
L6489_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L6489_RS00340	COG1098	S1 RNA binding domain
L6489_RS00355	COG2208	phosphoserine phosphatase activity
L6489_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L6489_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L6489_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6489_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L6489_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
L6489_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6489_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L6489_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L6489_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L6489_RS00420	COG1396	sequence-specific DNA binding
L6489_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6489_RS00515	COG3880	PFAM UvrB UvrC protein
L6489_RS00525	COG0542	response to heat
L6489_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L6489_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
L6489_RS00560	COG1045	serine acetyltransferase
L6489_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6489_RS00580	COG3688	RNA-binding protein containing a PIN domain
L6489_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6489_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
L6489_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L6489_RS00625	COG2813	Specifically methylates the guanine in position
L6489_RS00640	COG1358	cellular component organization or biogenesis
L6489_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
L6489_RS00770	COG0201	protein transport
L6489_RS00780	COG0024	Methionine aminopeptidase
L6489_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L6489_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L6489_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6489_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6489_RS00855	COG0489	protein tyrosine kinase activity
L6489_RS00865	COG2194	sulfuric ester hydrolase activity
L6489_RS00870	COG0726	polysaccharide deacetylase
L6489_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L6489_RS00955	COG4856	YbbR-like protein
L6489_RS00975	COG0596	Alpha beta hydrolase
L6489_RS00995	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L6489_RS01025	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS01030	COG2011	ABC-type metal ion transport system permease component
L6489_RS01040	COG1464	Belongs to the NlpA lipoprotein family
L6489_RS01045	COG0604	alcohol dehydrogenase
L6489_RS01055	COG0277	FAD linked oxidase domain protein
L6489_RS01060	COG2271	Major facilitator Superfamily
L6489_RS01070	COG2814	Major facilitator Superfamily
L6489_RS01085	COG0601	transmembrane transport
L6489_RS01090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6489_RS01095	COG0444	Belongs to the ABC transporter superfamily
L6489_RS01100	COG4608	Belongs to the ABC transporter superfamily
L6489_RS01105	COG4166	transmembrane transport
L6489_RS01115	COG2207	Transcriptional regulator
L6489_RS01125	COG1309	transcriptional regulator
L6489_RS01135	COG4166	transmembrane transport
L6489_RS01140	COG4166	transmembrane transport
L6489_RS01145	COG0656	L-ascorbic acid biosynthetic process
L6489_RS01150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6489_RS01165	COG4149	molybdate abc transporter
L6489_RS01170	COG0725	ABC transporter, periplasmic molybdate-binding protein
L6489_RS01175	COG1910	domain protein
L6489_RS01190	COG0697	spore germination
L6489_RS01205	COG0204	Acyl-transferase
L6489_RS01215	COG1609	Transcriptional regulator
L6489_RS01225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6489_RS01235	COG0084	hydrolase, TatD family'
L6489_RS01245	COG5298	Protein conserved in bacteria
L6489_RS01270	COG0488	(ABC) transporter
L6489_RS01275	COG4585	Histidine kinase
L6489_RS01280	COG2197	response regulator
L6489_RS01285	COG1131	(ABC) transporter
L6489_RS01290	COG0842	Transport permease protein
L6489_RS01290	COG1511	domain protein
L6489_RS01295	COG0842	Transport permease protein
L6489_RS01310	COG0747	negative chemotaxis
L6489_RS01315	COG0601	transmembrane transport
L6489_RS01320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6489_RS01325	COG0444	Belongs to the ABC transporter superfamily
L6489_RS01330	COG4608	Belongs to the ABC transporter superfamily
L6489_RS01335	COG0561	phosphatase activity
L6489_RS01365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L6489_RS01370	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6489_RS01380	COG2814	Major facilitator Superfamily
L6489_RS01390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L6489_RS01400	COG4294	response to UV
L6489_RS01405	COG0705	Rhomboid family
L6489_RS01405	COG0457	Tetratricopeptide repeat
L6489_RS01415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L6489_RS01420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6489_RS01425	COG0864	Transcriptional regulator
L6489_RS01430	COG2337	Toxic component of a toxin-antitoxin (TA) module
L6489_RS01435	COG2183	response to ionizing radiation
L6489_RS01530	COG0802	atpase or kinase
L6489_RS01535	COG1214	PFAM Peptidase M22, glycoprotease
L6489_RS01540	COG0456	acetyltransferase
L6489_RS01550	COG0488	(ABC) transporter
L6489_RS01565	COG1266	CAAX protease self-immunity
L6489_RS01585	COG2252	PERMEase
L6489_RS01595	COG5002	protein histidine kinase activity
L6489_RS01620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L6489_RS01695	COG2205	protein histidine kinase activity
L6489_RS01700	COG0745	RESPONSE REGULATOR receiver
L6489_RS01720	COG0697	spore germination
L6489_RS01750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L6489_RS01755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L6489_RS01760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L6489_RS01770	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L6489_RS01785	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L6489_RS01795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L6489_RS01805	COG0151	Belongs to the GarS family
L6489_RS01830	COG0210	DNA helicase
L6489_RS01840	COG4851	CamS sex pheromone cAM373 precursor
L6489_RS01860	COG1335	isochorismatase
L6489_RS01865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6489_RS01875	COG1464	Belongs to the NlpA lipoprotein family
L6489_RS01890	COG0003	Pfam Anion-transporting ATPase
L6489_RS01895	COG1846	Transcriptional regulator
L6489_RS01900	COG4682	membrane
L6489_RS01920	COG1597	lipid kinase activity
L6489_RS01925	COG0546	phosphoglycolate phosphatase activity
L6489_RS01930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6489_RS01940	COG1012	belongs to the aldehyde dehydrogenase family
L6489_RS01945	COG2076	Multidrug Resistance protein
L6489_RS01955	COG2309	aminopeptidase activity
L6489_RS01970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6489_RS01975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6489_RS01980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6489_RS01985	COG5002	protein histidine kinase activity
L6489_RS01990	COG4807	Protein conserved in bacteria
L6489_RS02015	COG1757	Na H antiporter
L6489_RS02020	COG1473	amidohydrolase
L6489_RS02035	COG0450	alkyl hydroperoxide reductase
L6489_RS02055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6489_RS02060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6489_RS02065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6489_RS02080	COG0166	Belongs to the GPI family
L6489_RS02125	COG3541	Predicted nucleotidyltransferase
L6489_RS02135	COG0723	plastoquinol--plastocyanin reductase activity
L6489_RS02135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6489_RS02160	COG0765	amino acid transport
L6489_RS02165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6489_RS02175	COG0840	transmembrane signaling receptor activity
L6489_RS02180	COG0840	transmembrane signaling receptor activity
L6489_RS02205	COG0366	Alpha amylase catalytic
L6489_RS02210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6489_RS02210	COG2190	(PTS) system
L6489_RS02210	COG1263	PTS System
L6489_RS02240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L6489_RS02255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6489_RS02265	COG1116	anion transmembrane transporter activity
L6489_RS02270	COG0488	(ABC) transporter
L6489_RS02320	COG2270	Major facilitator Superfamily
L6489_RS02350	COG2310	stress, protein
L6489_RS02355	COG2310	stress, protein
L6489_RS02360	COG2310	stress, protein
L6489_RS02365	COG0861	Integral membrane protein TerC family
L6489_RS02375	COG3853	Toxic anion resistance protein (TelA)
L6489_RS02390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L6489_RS02400	COG1295	ribonuclease BN
L6489_RS02405	COG2217	Heavy metal translocating P-type atpase
L6489_RS02410	COG0697	spore germination
L6489_RS02420	COG0681	Belongs to the peptidase S26 family
L6489_RS02430	COG0586	Pfam SNARE associated Golgi protein
L6489_RS02445	COG3871	stress protein (general stress protein 26)
L6489_RS02450	COG0387	Pfam Sodium calcium exchanger
L6489_RS02460	COG0535	radical SAM domain protein
L6489_RS02480	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L6489_RS02485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6489_RS02490	COG0101	tRNA pseudouridine synthase activity
L6489_RS02510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6489_RS02540	COG1263	PTS System
L6489_RS02540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6489_RS02545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6489_RS02565	COG0463	Glycosyl transferase, family 2
L6489_RS02575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6489_RS02590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6489_RS02610	COG1228	amidohydrolase
L6489_RS02615	COG1090	epimerase
L6489_RS02645	COG1988	membrane-bound metal-dependent
L6489_RS02650	COG1194	a g-specific adenine glycosylase
L6489_RS02675	COG1132	(ABC) transporter
L6489_RS02680	COG4129	membrane
L6489_RS02685	COG0067	glutamate synthase
L6489_RS02685	COG0069	glutamate synthase activity
L6489_RS02685	COG0070	glutamate synthase
L6489_RS02695	COG4555	ABC transporter
L6489_RS02715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L6489_RS02720	COG0735	belongs to the Fur family
L6489_RS02865	COG1201	RNA secondary structure unwinding
L6489_RS02940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6489_RS02960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L6489_RS02965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6489_RS02975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L6489_RS02985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L6489_RS02990	COG1716	ATPase activity
L6489_RS02990	COG5001	Diguanylate cyclase
L6489_RS02995	COG2766	serine protein kinase
L6489_RS03015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6489_RS03025	COG1585	Membrane protein implicated in regulation of membrane protease activity
L6489_RS03030	COG2268	Band 7 protein
L6489_RS03040	COG3290	protein histidine kinase activity
L6489_RS03045	COG4565	transcriptional regulatory protein
L6489_RS03050	COG2851	Citrate transporter
L6489_RS03070	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6489_RS03075	COG3842	ATPase activity
L6489_RS03080	COG1175	transmembrane transport
L6489_RS03085	COG0395	ABC-type sugar transport system, permease component
L6489_RS03100	COG0745	RESPONSE REGULATOR receiver
L6489_RS03105	COG5002	protein histidine kinase activity
L6489_RS03125	COG4990	cell redox homeostasis
L6489_RS03135	COG0697	spore germination
L6489_RS03140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6489_RS03150	COG5002	protein histidine kinase activity
L6489_RS03155	COG0745	RESPONSE REGULATOR receiver
L6489_RS03160	COG0454	-acetyltransferase
L6489_RS03160	COG0456	acetyltransferase
L6489_RS03165	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6489_RS03170	COG3383	formate dehydrogenase (NAD+) activity
L6489_RS03175	COG2427	Protein of unknown function (DUF1641)
L6489_RS03190	COG0531	amino acid
L6489_RS03195	COG0640	Transcriptional regulator
L6489_RS03200	COG2217	Heavy metal translocating P-type atpase
L6489_RS03205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L6489_RS03220	COG3227	Zinc metalloprotease (Elastase)
L6489_RS03240	COG2720	vancomycin resistance protein
L6489_RS03245	COG1316	TRANSCRIPTIONal
L6489_RS03250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6489_RS03255	COG0346	lactoylglutathione lyase activity
L6489_RS03260	COG1253	flavin adenine dinucleotide binding
L6489_RS03265	COG1027	Aspartate ammonia-lyase
L6489_RS03270	COG1620	l-lactate permease
L6489_RS03285	COG3104	oligopeptide transport
L6489_RS03290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6489_RS03295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6489_RS03300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6489_RS03310	COG2226	methyltransferase
L6489_RS03315	COG0156	8-amino-7-oxononanoate synthase activity
L6489_RS03320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6489_RS03325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L6489_RS03335	COG4548	von Willebrand factor, type A
L6489_RS03340	COG0714	Associated with various cellular activities
L6489_RS03345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6489_RS03360	COG0531	amino acid
L6489_RS03365	COG2188	Transcriptional regulator
L6489_RS03370	COG1263	PTS System
L6489_RS03370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6489_RS03375	COG0366	Alpha amylase catalytic
L6489_RS03390	COG0697	spore germination
L6489_RS03400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6489_RS03405	COG1115	amino acid carrier protein
L6489_RS03410	COG1126	abc transporter atp-binding protein
L6489_RS03415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6489_RS03420	COG0765	amino acid transport
L6489_RS03425	COG0765	amino acid transport
L6489_RS03430	COG0833	amino acid
L6489_RS03455	COG2378	regulation of single-species biofilm formation
L6489_RS03460	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L6489_RS03465	COG5002	protein histidine kinase activity
L6489_RS03480	COG0659	secondary active sulfate transmembrane transporter activity
L6489_RS03495	COG4166	transmembrane transport
L6489_RS03505	COG0601	transmembrane transport
L6489_RS03510	COG4608	Belongs to the ABC transporter superfamily
L6489_RS03520	COG2271	Major facilitator Superfamily
L6489_RS03525	COG1846	Transcriptional regulator
L6489_RS03530	COG0477	Major facilitator Superfamily
L6489_RS03535	COG1609	Transcriptional regulator
L6489_RS03540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6489_RS03555	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6489_RS03560	COG1879	ABC-type sugar transport system periplasmic component
L6489_RS03585	COG1063	alcohol dehydrogenase
L6489_RS03600	COG3568	Endonuclease Exonuclease Phosphatase
L6489_RS03630	COG0840	transmembrane signaling receptor activity
L6489_RS03635	COG1388	LysM domain
L6489_RS03635	COG3584	3D domain protein
L6489_RS03640	COG1476	TRANSCRIPTIONal
L6489_RS03655	COG3104	oligopeptide transport
L6489_RS03660	COG1114	Component of the transport system for branched-chain amino acids
L6489_RS03665	COG1464	Belongs to the NlpA lipoprotein family
L6489_RS03670	COG1960	acyl-CoA dehydrogenase activity
L6489_RS03675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6489_RS03680	COG2011	ABC-type metal ion transport system permease component
L6489_RS03695	COG1113	amino acid transport
L6489_RS03700	COG2252	PERMEase
L6489_RS03715	COG2153	protein acetylation
L6489_RS03725	COG0475	glutathione-regulated potassium exporter activity
L6489_RS03725	COG0569	domain protein
L6489_RS03740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L6489_RS03745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L6489_RS03750	COG4990	cell redox homeostasis
L6489_RS03765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6489_RS03770	COG0697	spore germination
L6489_RS03775	COG0531	amino acid
L6489_RS03785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6489_RS03790	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6489_RS03795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6489_RS03795	COG1918	ferrous iron import across plasma membrane
L6489_RS03800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6489_RS03805	COG0573	inorganic phosphate transmembrane transporter activity
L6489_RS03810	COG0581	inorganic phosphate transmembrane transporter activity
L6489_RS03815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6489_RS03935	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
L6489_RS03955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6489_RS03960	COG1116	anion transmembrane transporter activity
L6489_RS03965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6489_RS03970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6489_RS03975	COG0352	thiamine-phosphate diphosphorylase activity
L6489_RS03980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6489_RS03985	COG2104	thiamine diphosphate biosynthetic process
L6489_RS03995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6489_RS04000	COG0351	phosphomethylpyrimidine kinase
L6489_RS04040	COG2205	protein histidine kinase activity
L6489_RS04045	COG2814	Major facilitator Superfamily
L6489_RS04050	COG1846	Transcriptional regulator
L6489_RS04070	COG1136	(ABC) transporter
L6489_RS04080	COG2252	PERMEase
L6489_RS04085	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS04105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6489_RS04145	COG0778	Nitroreductase
L6489_RS04150	COG2719	SpoVR family
L6489_RS04160	COG3591	Belongs to the peptidase S1B family
L6489_RS04170	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6489_RS04175	COG1937	Protein conserved in bacteria
L6489_RS04180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6489_RS04180	COG0425	Belongs to the sulfur carrier protein TusA family
L6489_RS04185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6489_RS04185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6489_RS04190	COG0425	Belongs to the sulfur carrier protein TusA family
L6489_RS04195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6489_RS04205	COG2210	Belongs to the sulfur carrier protein TusA family
L6489_RS04210	COG0730	response to heat
L6489_RS04220	COG1316	TRANSCRIPTIONal
L6489_RS04225	COG0604	alcohol dehydrogenase
L6489_RS04230	COG1283	sodium-dependent phosphate transmembrane transporter activity
L6489_RS04245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6489_RS04245	COG3711	transcriptional antiterminator
L6489_RS04250	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6489_RS04255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6489_RS04275	COG1388	LysM domain
L6489_RS04275	COG3584	3D domain protein
L6489_RS04280	COG0577	efflux transmembrane transporter activity
L6489_RS04285	COG1136	(ABC) transporter
L6489_RS04295	COG5522	Integral membrane protein (intg_mem_TP0381)
L6489_RS04310	COG0577	efflux transmembrane transporter activity
L6489_RS04315	COG1114	Component of the transport system for branched-chain amino acids
L6489_RS04320	COG3546	catalase activity
L6489_RS04355	COG0586	Pfam SNARE associated Golgi protein
L6489_RS04390	COG0531	amino acid
L6489_RS04395	COG0475	glutathione-regulated potassium exporter activity
L6489_RS04405	COG1737	Transcriptional regulator
L6489_RS04415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6489_RS04415	COG1263	PTS System
L6489_RS04425	COG2259	Doxx family
L6489_RS04440	COG1522	sequence-specific DNA binding
L6489_RS04455	COG2076	Multidrug Resistance protein
L6489_RS04460	COG1309	transcriptional regulator
L6489_RS04465	COG2814	Major facilitator Superfamily
L6489_RS04470	COG0657	acetylesterase activity
L6489_RS04475	COG1309	transcriptional regulator
L6489_RS04480	COG2124	cytochrome p450
L6489_RS04490	COG1063	alcohol dehydrogenase
L6489_RS04495	COG4533	DNA binding
L6489_RS04500	COG2211	Major facilitator Superfamily
L6489_RS04510	COG0693	protein deglycase activity
L6489_RS04515	COG0753	catalase activity
L6489_RS04525	COG0531	amino acid
L6489_RS04530	COG1012	belongs to the aldehyde dehydrogenase family
L6489_RS04535	COG1132	(ABC) transporter
L6489_RS04540	COG1132	(ABC) transporter
L6489_RS04545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6489_RS04550	COG0765	amino acid transport
L6489_RS04555	COG1126	abc transporter atp-binding protein
L6489_RS04570	COG0189	ligase activity
L6489_RS04600	COG0028	Belongs to the TPP enzyme family
L6489_RS04605	COG3527	Alpha-acetolactate decarboxylase
L6489_RS04615	COG0561	phosphatase activity
L6489_RS04620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6489_RS04635	COG0659	secondary active sulfate transmembrane transporter activity
L6489_RS04655	COG2244	polysaccharide biosynthetic process
L6489_RS04670	COG4193	domain, Protein
L6489_RS04670	COG5263	repeat protein
L6489_RS04685	COG1024	Enoyl-CoA hydratase
L6489_RS04705	COG1363	Peptidase, m42
L6489_RS04835	COG1649	PFAM Uncharacterised BCR, COG1649
L6489_RS04870	COG0601	transmembrane transport
L6489_RS04875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6489_RS04880	COG0444	Belongs to the ABC transporter superfamily
L6489_RS04885	COG4608	Belongs to the ABC transporter superfamily
L6489_RS04915	COG0477	Major facilitator Superfamily
L6489_RS04920	COG3290	protein histidine kinase activity
L6489_RS04925	COG4565	transcriptional regulatory protein
L6489_RS04930	COG3181	Tripartite tricarboxylate transporter family receptor
L6489_RS04945	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
L6489_RS04975	COG0789	Transcriptional regulator
L6489_RS04975	COG4978	Transcriptional regulator
L6489_RS05015	COG0305	Participates in initiation and elongation during chromosome replication
L6489_RS05065	COG0477	Major facilitator Superfamily
L6489_RS05140	COG1404	Belongs to the peptidase S8 family
L6489_RS05210	COG3711	transcriptional antiterminator
L6489_RS05215	COG1263	PTS System
L6489_RS05215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6489_RS05215	COG2190	(PTS) system
L6489_RS05220	COG2723	6-phospho-beta-galactosidase activity
L6489_RS05240	COG0367	asparagine synthase
L6489_RS05255	COG1132	(ABC) transporter
L6489_RS05265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6489_RS05265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L6489_RS05305	COG0577	efflux transmembrane transporter activity
L6489_RS05305	COG1136	(ABC) transporter
L6489_RS05325	COG1183	phosphatidylcholine synthase activity
L6489_RS05340	COG2376	Dihydroxyacetone kinase
L6489_RS05350	COG2376	Dihydroxyacetone kinase
L6489_RS05445	COG3237	CsbD-like
L6489_RS05470	COG1191	sigma factor activity
L6489_RS05480	COG2208	phosphoserine phosphatase activity
L6489_RS05485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6489_RS05490	COG0784	Response regulator, receiver
L6489_RS05490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6489_RS05490	COG2198	Histidine kinase
L6489_RS05490	COG2205	protein histidine kinase activity
L6489_RS05525	COG0745	RESPONSE REGULATOR receiver
L6489_RS05530	COG2205	protein histidine kinase activity
L6489_RS05570	COG0420	3'-5' exonuclease activity
L6489_RS05575	COG4717	serine-type aminopeptidase activity
L6489_RS05590	COG0346	lactoylglutathione lyase activity
L6489_RS05595	COG0346	lactoylglutathione lyase activity
L6489_RS05600	COG0457	Tetratricopeptide repeat
L6489_RS05610	COG2267	carboxylic ester hydrolase activity
L6489_RS05640	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6489_RS05645	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L6489_RS05655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L6489_RS05700	COG0477	Major facilitator Superfamily
L6489_RS05705	COG0477	Major facilitator Superfamily
L6489_RS05715	COG3973	AAA domain
L6489_RS05720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6489_RS05740	COG4980	gas vesicle protein
L6489_RS05745	COG0537	adenosine 5'-monophosphoramidase activity
L6489_RS05750	COG1131	(ABC) transporter
L6489_RS05755	COG4473	ABC transporter
L6489_RS05770	COG1309	transcriptional regulator
L6489_RS05780	COG3402	PFAM membrane-flanked domain
L6489_RS05785	COG3428	Bacterial PH domain
L6489_RS05815	COG3402	PFAM membrane-flanked domain
L6489_RS05820	COG3428	Bacterial PH domain
L6489_RS05825	COG2329	Antibiotic biosynthesis monooxygenase
L6489_RS05830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6489_RS05845	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6489_RS05870	COG1309	transcriptional regulator
L6489_RS05875	COG1511	domain protein
L6489_RS05905	COG2378	regulation of single-species biofilm formation
L6489_RS05910	COG1609	Transcriptional regulator
L6489_RS05920	COG1234	tRNA 3'-trailer cleavage
L6489_RS05925	COG0095	Lipoate-protein ligase
L6489_RS05930	COG3328	transposase activity
L6489_RS05935	COG2205	protein histidine kinase activity
L6489_RS05940	COG0745	RESPONSE REGULATOR receiver
L6489_RS05965	COG0501	Belongs to the peptidase M48B family
L6489_RS05970	COG0697	spore germination
L6489_RS05990	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L6489_RS05995	COG2224	Isocitrate lyase
L6489_RS06005	COG1278	Cold shock
L6489_RS06020	COG4903	ComK protein
L6489_RS06030	COG4585	Histidine kinase
L6489_RS06035	COG2197	response regulator
L6489_RS06045	COG0398	Pfam SNARE associated Golgi protein
L6489_RS06120	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6489_RS06145	COG0367	asparagine synthase
L6489_RS06150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6489_RS06155	COG0753	catalase activity
L6489_RS06165	COG0004	ammonium transporteR
L6489_RS06185	COG2996	Protein conserved in bacteria
L6489_RS06190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6489_RS06200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6489_RS06215	COG0561	phosphatase activity
L6489_RS06225	COG0542	response to heat
L6489_RS06235	COG2267	carboxylic ester hydrolase activity
L6489_RS06250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6489_RS06255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6489_RS06260	COG5504	Zn-dependent protease
L6489_RS06270	COG0180	Tryptophanyl-tRNA synthetase
L6489_RS06280	COG4166	transmembrane transport
L6489_RS06285	COG0601	transmembrane transport
L6489_RS06290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6489_RS06295	COG0444	Belongs to the ABC transporter superfamily
L6489_RS06300	COG4608	Belongs to the ABC transporter superfamily
L6489_RS06305	COG0534	Mate efflux family protein
L6489_RS06310	COG4166	transmembrane transport
L6489_RS06325	COG0861	Integral membrane protein TerC family
L6489_RS06330	COG4862	establishment of competence for transformation
L6489_RS06335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6489_RS06345	COG1164	Oligoendopeptidase f
L6489_RS06360	COG2346	COG2346, Truncated hemoglobins
L6489_RS06365	COG4116	CYTH
L6489_RS06375	COG2357	RelA SpoT domain protein
L6489_RS06385	COG0564	pseudouridine synthase activity
L6489_RS06400	COG0772	Belongs to the SEDS family
L6489_RS06405	COG1216	Glycosyl transferase, family 2
L6489_RS06425	COG0463	Glycosyl transferase, family 2
L6489_RS06425	COG0457	Tetratricopeptide repeat
L6489_RS06445	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L6489_RS06460	COG1091	dTDP-4-dehydrorhamnose reductase activity
L6489_RS06505	COG2153	protein acetylation
L6489_RS06515	COG2382	esterase
L6489_RS06530	COG5492	domain, Protein
L6489_RS06535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6489_RS06545	COG0512	Glutamine amidotransferase of anthranilate synthase
L6489_RS06545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L6489_RS06580	COG1620	l-lactate permease
L6489_RS06585	COG5634	Uncharacterized conserved protein (DUF2278)
L6489_RS06650	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6489_RS06660	COG1476	TRANSCRIPTIONal
L6489_RS06705	COG2226	methyltransferase
L6489_RS06715	COG1686	Belongs to the peptidase S11 family
L6489_RS06720	COG0681	Belongs to the peptidase S26 family
L6489_RS06740	COG1396	sequence-specific DNA binding
L6489_RS06755	COG1012	belongs to the aldehyde dehydrogenase family
L6489_RS06765	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6489_RS06770	COG1177	transmembrane transport
L6489_RS06775	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L6489_RS06785	COG2409	Drug exporters of the RND superfamily
L6489_RS06795	COG0564	pseudouridine synthase activity
L6489_RS06805	COG2340	Cysteine-rich secretory protein family
L6489_RS06810	COG0247	lactate metabolic process
L6489_RS06815	COG0277	FAD linked oxidase domain protein
L6489_RS06820	COG3835	regulator
L6489_RS06830	COG0745	RESPONSE REGULATOR receiver
L6489_RS06835	COG5002	protein histidine kinase activity
L6489_RS06840	COG2186	Transcriptional regulator
L6489_RS06860	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L6489_RS06870	COG2116	formate transmembrane transporter activity
L6489_RS06875	COG0861	Integral membrane protein TerC family
L6489_RS06880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6489_RS06890	COG2030	dehydratase
L6489_RS06910	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS06915	COG3243	poly(R)-hydroxyalkanoic acid synthase
L6489_RS06920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6489_RS06925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6489_RS06945	COG1840	ABC-type Fe3 transport system, periplasmic component
L6489_RS06950	COG3842	ATPase activity
L6489_RS06975	COG1349	DNA-binding transcription factor activity
L6489_RS06985	COG0235	Class ii aldolase
L6489_RS06995	COG2861	carbohydrate metabolic process
L6489_RS07005	COG3852	Histidine kinase
L6489_RS07020	COG2318	DinB family
L6489_RS07030	COG5002	protein histidine kinase activity
L6489_RS07040	COG0720	synthase
L6489_RS07055	COG4873	Protein conserved in bacteria
L6489_RS07085	COG1780	Probably involved in ribonucleotide reductase function
L6489_RS07095	COG1403	HNH endonuclease
L6489_RS07105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6489_RS07110	COG1725	Transcriptional regulator
L6489_RS07115	COG1131	(ABC) transporter
L6489_RS07125	COG1131	(ABC) transporter
L6489_RS07130	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6489_RS07145	COG1522	sequence-specific DNA binding
L6489_RS07155	COG1335	isochorismatase
L6489_RS07165	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6489_RS07170	COG2070	2-Nitropropane dioxygenase
L6489_RS07175	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6489_RS07185	COG1696	Membrane protein involved in D-alanine export
L6489_RS07210	COG0716	FMN binding
L6489_RS07225	COG3173	Aminoglycoside phosphotransferase
L6489_RS07245	COG0534	Mate efflux family protein
L6489_RS07250	COG1968	undecaprenyl-diphosphatase activity
L6489_RS07265	COG1846	Transcriptional regulator
L6489_RS07275	COG1301	dicarboxylic acid transport
L6489_RS07280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6489_RS07285	COG4709	membrane
L6489_RS07290	COG3874	Sporulation protein YtfJ
L6489_RS07310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6489_RS07315	COG0028	Belongs to the TPP enzyme family
L6489_RS07320	COG0440	acetolactate synthase activity
L6489_RS07395	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6489_RS07410	COG1183	phosphatidylcholine synthase activity
L6489_RS07415	COG1368	sulfuric ester hydrolase activity
L6489_RS07425	COG0019	diaminopimelate decarboxylase activity
L6489_RS07445	COG0529	Catalyzes the synthesis of activated sulfate
L6489_RS07450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6489_RS07470	COG1648	precorrin-2 dehydrogenase activity
L6489_RS07475	COG0733	neurotransmitter:sodium symporter activity
L6489_RS07495	COG1757	Na H antiporter
L6489_RS07510	COG4758	membrane
L6489_RS07515	COG4585	Histidine kinase
L6489_RS07520	COG2197	response regulator
L6489_RS07530	COG1114	Component of the transport system for branched-chain amino acids
L6489_RS07540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6489_RS07580	COG0730	response to heat
L6489_RS07585	COG0306	phosphate transporter
L6489_RS07590	COG1392	Phosphate transport regulator
L6489_RS07595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6489_RS07610	COG3852	Histidine kinase
L6489_RS07615	COG1801	Protein of unknown function DUF72
L6489_RS07630	COG0582	viral genome integration into host DNA
L6489_RS07635	COG5002	protein histidine kinase activity
L6489_RS07655	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L6489_RS07655	COG0392	lysyltransferase activity
L6489_RS07670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6489_RS07675	COG1686	Belongs to the peptidase S11 family
L6489_RS07680	COG2715	membrane protein required for spore maturation
L6489_RS07685	COG0700	Nucleoside recognition
L6489_RS07690	COG1187	pseudouridine synthase activity
L6489_RS07700	COG1333	cytochrome c biogenesis protein
L6489_RS07705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6489_RS07710	COG0745	RESPONSE REGULATOR receiver
L6489_RS07715	COG5002	protein histidine kinase activity
L6489_RS07720	COG2096	Adenosyltransferase
L6489_RS07725	COG4942	peptidase
L6489_RS07735	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L6489_RS07740	COG1141	Ferredoxin
L6489_RS07750	COG0514	ATP-dependent DNA helicase (RecQ)
L6489_RS07755	COG1266	CAAX protease self-immunity
L6489_RS07765	COG1408	metallophosphoesterase
L6489_RS07775	COG4862	establishment of competence for transformation
L6489_RS07780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L6489_RS07800	COG0492	ferredoxin-NADP+ reductase activity
L6489_RS07805	COG0252	asparaginase activity
L6489_RS07875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6489_RS07890	COG0142	geranyltranstransferase activity
L6489_RS07900	COG0142	geranyltranstransferase activity
L6489_RS07925	COG0457	Tetratricopeptide repeat
L6489_RS07945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L6489_RS07955	COG4347	Protein of unknown function (DUF1405)
L6489_RS07970	COG2738	Putative neutral zinc metallopeptidase
L6489_RS07980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6489_RS07985	COG1694	Mazg nucleotide pyrophosphohydrolase
L6489_RS08000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6489_RS08005	COG0438	transferase activity, transferring glycosyl groups
L6489_RS08040	COG1199	ATP-dependent helicase activity
L6489_RS08040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L6489_RS08060	COG3935	DnaD domain protein
L6489_RS08065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L6489_RS08075	COG4499	WXG100 protein secretion system (Wss), protein YukC
L6489_RS08075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6489_RS08135	COG0116	Belongs to the methyltransferase superfamily
L6489_RS08145	COG1199	ATP-dependent helicase activity
L6489_RS08150	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L6489_RS08160	COG3173	Aminoglycoside phosphotransferase
L6489_RS08165	COG0024	Methionine aminopeptidase
L6489_RS08175	COG2233	PERMEase
L6489_RS08180	COG2311	Membrane
L6489_RS08185	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6489_RS08195	COG0456	acetyltransferase
L6489_RS08235	COG0754	glutathionylspermidine amidase activity
L6489_RS08250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6489_RS08265	COG0454	-acetyltransferase
L6489_RS08285	COG0328	RNA-DNA hybrid ribonuclease activity
L6489_RS08320	COG3403	YqcI/YcgG family
L6489_RS08325	COG1280	lysine exporter protein (LysE YggA)
L6489_RS08340	COG3162	membrane
L6489_RS08345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6489_RS08350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6489_RS08360	COG0475	glutathione-regulated potassium exporter activity
L6489_RS08365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6489_RS08370	COG0789	Transcriptional regulator
L6489_RS08370	COG4978	Transcriptional regulator
L6489_RS08380	COG2323	membrane
L6489_RS08385	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L6489_RS08420	COG2814	Major facilitator Superfamily
L6489_RS08450	COG1923	regulation of RNA biosynthetic process
L6489_RS08460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6489_RS08465	COG1360	Flagellar Motor Protein
L6489_RS08470	COG2201	protein-glutamate methylesterase activity
L6489_RS08475	COG2198	Histidine kinase
L6489_RS08475	COG0643	Histidine kinase
L6489_RS08480	COG1776	CheC inhibitor of MCP methylation
L6489_RS08480	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6489_RS08495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6489_RS08515	COG1256	bacterial-type flagellum assembly
L6489_RS08520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L6489_RS08525	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
L6489_RS08540	COG1815	bacterial-type flagellum-dependent cell motility
L6489_RS08545	COG1558	bacterial-type flagellum-dependent cell motility
L6489_RS08555	COG1766	The M ring may be actively involved in energy transduction
L6489_RS08560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6489_RS08570	COG1157	protein secretion by the type III secretion system
L6489_RS08605	COG0835	chemotaxis
L6489_RS08605	COG0784	Response regulator, receiver
L6489_RS08615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L6489_RS08625	COG0741	lytic transglycosylase activity
L6489_RS08635	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6489_RS08640	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6489_RS08640	COG1776	CheC inhibitor of MCP methylation
L6489_RS08650	COG1338	Plays a role in the flagellum-specific transport system
L6489_RS08655	COG1987	bacterial-type flagellum assembly
L6489_RS08665	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6489_RS08670	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6489_RS08675	COG1419	protein localization to endoplasmic reticulum
L6489_RS08680	COG4786	Flagellar basal body rod
L6489_RS08685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6489_RS08710	COG1309	transcriptional regulator
L6489_RS08730	COG2329	Antibiotic biosynthesis monooxygenase
L6489_RS08745	COG3764	Sortase (surface protein transpeptidase)
L6489_RS08750	COG3764	Sortase (surface protein transpeptidase)
L6489_RS08775	COG0583	DNA-binding transcription factor activity
L6489_RS08780	COG3842	ATPase activity
L6489_RS08785	COG0725	ABC transporter, periplasmic molybdate-binding protein
L6489_RS08795	COG1234	tRNA 3'-trailer cleavage
L6489_RS08810	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS08825	COG0406	alpha-ribazole phosphatase activity
L6489_RS08845	COG1846	Transcriptional regulator
L6489_RS08855	COG0367	asparagine synthase
L6489_RS08885	COG1802	Transcriptional regulator
L6489_RS08890	COG0697	spore germination
L6489_RS08895	COG0523	cobalamin synthesis protein
L6489_RS08900	COG0701	Predicted permease
L6489_RS08915	COG1757	Na H antiporter
L6489_RS08920	COG0114	fumarate hydratase activity
L6489_RS08935	COG0534	Mate efflux family protein
L6489_RS08940	COG3340	Belongs to the peptidase S51 family
L6489_RS08960	COG0785	Cytochrome C biogenesis protein
L6489_RS08995	COG2733	membrane
L6489_RS09030	COG1131	(ABC) transporter
L6489_RS09045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6489_RS09070	COG0528	UMP kinase activity
L6489_RS09080	COG1027	Aspartate ammonia-lyase
L6489_RS09085	COG0281	malic enzyme
L6489_RS09090	COG4191	Histidine kinase
L6489_RS09095	COG0784	Response regulator, receiver
L6489_RS09105	COG1361	Conserved repeat domain
L6489_RS09220	COG2814	Major facilitator Superfamily
L6489_RS09235	COG1966	Carbon starvation protein
L6489_RS09245	COG1695	Transcriptional regulator
L6489_RS09255	COG0477	Major facilitator Superfamily
L6489_RS09260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6489_RS09265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L6489_RS09270	COG4166	transmembrane transport
L6489_RS09275	COG2223	nitrite transmembrane transporter activity
L6489_RS09280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6489_RS09295	COG2244	polysaccharide biosynthetic process
L6489_RS09300	COG0733	neurotransmitter:sodium symporter activity
L6489_RS09310	COG5566	PFAM Mor transcription activator
L6489_RS09315	COG2323	membrane
L6489_RS09330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6489_RS09340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6489_RS09345	COG0028	Belongs to the TPP enzyme family
L6489_RS09355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6489_RS09365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6489_RS09390	COG2814	Major facilitator Superfamily
L6489_RS09395	COG3384	dioxygenase
L6489_RS09405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L6489_RS09415	COG0427	acetyl-CoA hydrolase
L6489_RS09435	COG1073	alpha beta
L6489_RS09440	COG4166	transmembrane transport
L6489_RS09465	COG0535	radical SAM domain protein
L6489_RS09470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6489_RS09495	COG1914	H( )-stimulated, divalent metal cation uptake system
L6489_RS09510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6489_RS09515	COG0531	amino acid
L6489_RS09550	COG0714	Associated with various cellular activities
L6489_RS09560	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L6489_RS09585	COG2390	Transcriptional regulator
L6489_RS09595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6489_RS09600	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L6489_RS09630	COG0006	proline dipeptidase activity
L6489_RS09635	COG2132	Multicopper oxidase
L6489_RS09650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6489_RS09680	COG1114	Component of the transport system for branched-chain amino acids
L6489_RS09690	COG1276	copper resistance
L6489_RS09690	COG2372	response to copper ion
L6489_RS09695	COG4549	nuclear export factor GLE1
L6489_RS09705	COG0697	spore germination
L6489_RS09710	COG0583	DNA-binding transcription factor activity
L6489_RS09715	COG1959	2 iron, 2 sulfur cluster binding
L6489_RS09720	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L6489_RS09725	COG0778	Nitroreductase
L6489_RS09735	COG0628	permease
L6489_RS09745	COG1231	oxidoreductase activity
L6489_RS09750	COG0523	cobalamin synthesis protein
L6489_RS09760	COG0318	PFAM AMP-dependent synthetase and ligase
L6489_RS09765	COG2030	dehydratase
L6489_RS09770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6489_RS09780	COG0411	ABC transporter
L6489_RS09800	COG0583	DNA-binding transcription factor activity
L6489_RS09830	COG1271	oxidase subunit
L6489_RS09835	COG1294	oxidase, subunit
L6489_RS09840	COG4988	ABC transporter
L6489_RS09845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L6489_RS09865	COG1686	Belongs to the peptidase S11 family
L6489_RS09880	COG0791	NLP P60 protein
L6489_RS09880	COG1388	LysM domain
L6489_RS09890	COG1132	(ABC) transporter
L6489_RS09895	COG0745	RESPONSE REGULATOR receiver
L6489_RS09900	COG5002	protein histidine kinase activity
L6489_RS09905	COG2205	protein histidine kinase activity
L6489_RS09910	COG0745	RESPONSE REGULATOR receiver
L6489_RS09935	COG0300	oxidoreductase activity
L6489_RS09940	COG4122	O-methyltransferase activity
L6489_RS09955	COG5658	integral membrane protein
L6489_RS09970	COG0460	homoserine dehydrogenase
L6489_RS09995	COG1316	TRANSCRIPTIONal
L6489_RS10005	COG0745	RESPONSE REGULATOR receiver
L6489_RS10010	COG5002	protein histidine kinase activity
L6489_RS10025	COG1285	pathogenesis
L6489_RS10030	COG1247	-acetyltransferase
L6489_RS10050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6489_RS10060	COG1082	Xylose isomerase domain protein TIM barrel
L6489_RS10070	COG2814	Major facilitator Superfamily
L6489_RS10075	COG1279	arginine transmembrane transporter activity
L6489_RS10085	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6489_RS10120	COG0577	efflux transmembrane transporter activity
L6489_RS10125	COG2002	toxin-antitoxin pair type II binding
L6489_RS10130	COG1404	Belongs to the peptidase S8 family
L6489_RS10135	COG0640	Transcriptional regulator
L6489_RS10140	COG0667	Aldo Keto reductase
L6489_RS10145	COG2814	Major facilitator Superfamily
L6489_RS10170	COG0840	transmembrane signaling receptor activity
L6489_RS10185	COG3949	Membrane
L6489_RS10190	COG0783	Belongs to the Dps family
L6489_RS10205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6489_RS10215	COG1231	oxidoreductase activity
L6489_RS10225	COG4989	oxidoreductase activity
L6489_RS10230	COG0523	cobalamin synthesis protein
L6489_RS10235	COG0456	acetyltransferase
L6489_RS10240	COG3443	Belongs to the bacterial solute-binding protein 9 family
L6489_RS10240	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6489_RS10250	COG0702	epimerase
L6489_RS10260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6489_RS10270	COG4166	transmembrane transport
L6489_RS10285	COG0406	alpha-ribazole phosphatase activity
L6489_RS10295	COG5337	Spore coat protein CotH
L6489_RS10300	COG1051	belongs to the nudix hydrolase family
L6489_RS10305	COG0586	Pfam SNARE associated Golgi protein
L6489_RS10310	COG2244	polysaccharide biosynthetic process
L6489_RS10320	COG0701	Predicted permease
L6489_RS10325	COG3689	TIGRFAM TIGR03943 family protein
L6489_RS10330	COG1607	acyl-coa hydrolase
L6489_RS10340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6489_RS10355	COG0702	epimerase
L6489_RS10360	COG2839	Protein conserved in bacteria
L6489_RS10365	COG1253	flavin adenine dinucleotide binding
L6489_RS10380	COG1114	Component of the transport system for branched-chain amino acids
L6489_RS10385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6489_RS10405	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6489_RS10415	COG1876	peptidase activity
L6489_RS10425	COG0154	amidase activity
L6489_RS10430	COG2211	Major facilitator Superfamily
L6489_RS10445	COG2368	4-hydroxyphenylacetate
L6489_RS10455	COG0196	riboflavin kinase activity
L6489_RS10470	COG0251	oxidation-reduction process
L6489_RS10480	COG3971	2-oxopent-4-enoate hydratase activity
L6489_RS10500	COG1942	4-Oxalocrotonate Tautomerase
L6489_RS10520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6489_RS10525	COG4106	trans-aconitate 2-methyltransferase activity
L6489_RS10540	COG1819	glycosyl
L6489_RS10545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6489_RS10550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6489_RS10580	COG0456	acetyltransferase
L6489_RS10620	COG4499	WXG100 protein secretion system (Wss), protein YukC
L6489_RS10720	COG3874	Sporulation protein YtfJ
L6489_RS10745	COG2226	methyltransferase
L6489_RS10770	COG0346	lactoylglutathione lyase activity
L6489_RS10780	COG0604	alcohol dehydrogenase
L6489_RS10785	COG1595	DNA-templated transcription, initiation
L6489_RS10815	COG0386	Belongs to the glutathione peroxidase family
L6489_RS10820	COG1305	Transglutaminase-like
L6489_RS10825	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
L6489_RS10830	COG0714	Associated with various cellular activities
L6489_RS10845	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
L6489_RS10850	COG1140	nitrate reductase beta subunit
L6489_RS10855	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
L6489_RS10860	COG2181	nitrate reductase activity
L6489_RS10865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6489_RS10870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L6489_RS10875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6489_RS10880	COG0303	'Molybdopterin
L6489_RS10885	COG0314	molybdopterin synthase activity
L6489_RS10895	COG2223	nitrite transmembrane transporter activity
L6489_RS10905	COG1648	precorrin-2 dehydrogenase activity
L6489_RS10915	COG1587	Uroporphyrinogen-III synthase
L6489_RS10915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6489_RS10920	COG2146	nitrite reductase [NAD(P)H] activity
L6489_RS10925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6489_RS10930	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
L6489_RS10965	COG2359	stage V sporulation protein S
L6489_RS10990	COG1418	mRNA catabolic process
L6489_RS10995	COG0488	(ABC) transporter
L6489_RS11010	COG0629	single-stranded DNA binding
L6489_RS11025	COG1413	lyase activity
L6489_RS11040	COG2521	methyltransferase
L6489_RS11040	COG2136	Putative SAM-dependent methyltransferase
L6489_RS11065	COG3328	transposase activity
L6489_RS11090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L6489_RS11095	COG0017	Asparaginyl-tRNA synthetase
L6489_RS11100	COG1929	Belongs to the glycerate kinase type-1 family
L6489_RS11105	COG0471	metal ion transport
L6489_RS11110	COG0745	RESPONSE REGULATOR receiver
L6489_RS11130	COG0733	neurotransmitter:sodium symporter activity
L6489_RS11155	COG2610	gluconate transmembrane transporter activity
L6489_RS11160	COG1454	alcohol dehydrogenase
L6489_RS11165	COG1794	racemase activity, acting on amino acids and derivatives
L6489_RS11175	COG0456	acetyltransferase
L6489_RS11180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L6489_RS11190	COG1131	(ABC) transporter
L6489_RS11195	COG4473	ABC transporter
L6489_RS11205	COG0546	phosphoglycolate phosphatase activity
L6489_RS11225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6489_RS11230	COG3250	beta-galactosidase activity
L6489_RS11245	COG0768	penicillin binding
L6489_RS11255	COG0204	Acyl-transferase
L6489_RS11260	COG1272	protein, Hemolysin III
L6489_RS11270	COG0805	protein transport
L6489_RS11280	COG1307	EDD domain protein, DegV family
L6489_RS11290	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L6489_RS11295	COG1999	signal sequence binding
L6489_RS11300	COG0071	Belongs to the small heat shock protein (HSP20) family
L6489_RS11305	COG0367	asparagine synthase
L6489_RS11325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6489_RS11330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6489_RS11350	COG1335	isochorismatase
L6489_RS11355	COG0071	Belongs to the small heat shock protein (HSP20) family
L6489_RS11360	COG0668	transmembrane transport
L6489_RS11365	COG2203	Gaf domain
L6489_RS11365	COG4585	Histidine kinase
L6489_RS11370	COG2197	response regulator
L6489_RS11380	COG1064	alcohol dehydrogenase
L6489_RS11435	COG0517	IMP dehydrogenase activity
L6489_RS11435	COG1125	glycine betaine transport
L6489_RS11440	COG1174	glycine betaine transport
L6489_RS11480	COG1253	flavin adenine dinucleotide binding
L6489_RS11485	COG1012	belongs to the aldehyde dehydrogenase family
L6489_RS11490	COG5506	Protein of unknown function (DUF1694)
L6489_RS11505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6489_RS11510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L6489_RS11515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L6489_RS11520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6489_RS11525	COG0456	acetyltransferase
L6489_RS11530	COG3829	transcription factor binding
L6489_RS11535	COG1509	lysine 2,3-aminomutase activity
L6489_RS11570	COG3064	Membrane
L6489_RS11570	COG4991	sh3 domain protein
L6489_RS11570	COG0515	serine threonine protein kinase
L6489_RS11575	COG4326	sporulation control protein
L6489_RS11580	COG0671	phosphoesterase, PA-phosphatase related
L6489_RS11605	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6489_RS11605	COG0456	acetyltransferase
L6489_RS11625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6489_RS11630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6489_RS11680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6489_RS11710	COG0300	oxidoreductase activity
L6489_RS11730	COG4499	WXG100 protein secretion system (Wss), protein YukC
L6489_RS11730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6489_RS11745	COG4841	protein insertion into membrane
L6489_RS11750	COG0372	Belongs to the citrate synthase family
L6489_RS11755	COG2079	MmgE PrpD family protein
L6489_RS11760	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L6489_RS11765	COG1960	acyl-CoA dehydrogenase activity
L6489_RS11770	COG2084	Dehydrogenase
L6489_RS11780	COG1280	lysine exporter protein (LysE YggA)
L6489_RS11785	COG1024	Enoyl-CoA hydratase
L6489_RS11800	COG0420	3'-5' exonuclease activity
L6489_RS11825	COG2223	nitrite transmembrane transporter activity
L6489_RS11830	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS11835	COG1169	isochorismate synthase
L6489_RS11840	COG1021	2,3-dihydroxybenzoate-AMP ligase
L6489_RS11845	COG1535	isochorismatase
L6489_RS11845	COG3433	isochorismatase activity
L6489_RS11850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6489_RS11855	COG3251	PFAM MbtH domain protein
L6489_RS11860	COG2814	Major facilitator Superfamily
L6489_RS11875	COG0776	regulation of translation
L6489_RS11885	COG2318	DinB family
L6489_RS11895	COG1115	amino acid carrier protein
L6489_RS11910	COG2329	Antibiotic biosynthesis monooxygenase
L6489_RS11915	COG1187	pseudouridine synthase activity
L6489_RS11920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6489_RS11925	COG1136	(ABC) transporter
L6489_RS11940	COG2814	Major facilitator Superfamily
L6489_RS12000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6489_RS12035	COG1247	-acetyltransferase
L6489_RS12065	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6489_RS12075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6489_RS12085	COG1278	Cold shock
L6489_RS12100	COG0010	Belongs to the arginase family
L6489_RS12110	COG1846	Transcriptional regulator
L6489_RS12115	COG2814	Major facilitator Superfamily
L6489_RS12120	COG0583	DNA-binding transcription factor activity
L6489_RS12125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6489_RS12140	COG0583	DNA-binding transcription factor activity
L6489_RS12145	COG2258	MOSC domain
L6489_RS12160	COG1132	(ABC) transporter
L6489_RS12165	COG1132	(ABC) transporter
L6489_RS12185	COG1396	sequence-specific DNA binding
L6489_RS12215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6489_RS12225	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
L6489_RS12230	COG1595	DNA-templated transcription, initiation
L6489_RS12255	COG1649	PFAM Uncharacterised BCR, COG1649
L6489_RS12280	COG2971	BadF BadG BcrA BcrD
L6489_RS12290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L6489_RS12310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6489_RS12340	COG1309	transcriptional regulator
L6489_RS12355	COG1136	(ABC) transporter
L6489_RS12355	COG0577	efflux transmembrane transporter activity
L6489_RS12405	COG1846	Transcriptional regulator
L6489_RS12435	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6489_RS12445	COG0110	maltose O-acetyltransferase activity
L6489_RS12450	COG1686	Belongs to the peptidase S11 family
L6489_RS12460	COG0768	penicillin binding
L6489_RS12465	COG1595	DNA-templated transcription, initiation
L6489_RS12475	COG0768	penicillin binding
L6489_RS12480	COG0768	penicillin binding
L6489_RS12485	COG2367	Beta-lactamase
L6489_RS12500	COG1131	(ABC) transporter
L6489_RS12510	COG1309	transcriptional regulator
L6489_RS12525	COG1960	acyl-CoA dehydrogenase activity
L6489_RS12530	COG0439	Biotin carboxylase
L6489_RS12535	COG0511	ligase activity, forming carbon-carbon bonds
L6489_RS12540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6489_RS12545	COG1024	Enoyl-CoA hydratase
L6489_RS12550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L6489_RS12555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6489_RS12565	COG1247	-acetyltransferase
L6489_RS12570	COG0572	uridine kinase
L6489_RS12580	COG1686	Belongs to the peptidase S11 family
L6489_RS12605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L6489_RS12625	COG3227	Zinc metalloprotease (Elastase)
L6489_RS12640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6489_RS12670	COG2814	Major facilitator Superfamily
L6489_RS12680	COG2226	methyltransferase
L6489_RS12715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6489_RS12760	COG3386	PFAM SMP-30 Gluconolaconase
L6489_RS12770	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
L6489_RS12775	COG3773	Cell wall hydrolase
L6489_RS12785	COG0745	RESPONSE REGULATOR receiver
L6489_RS12790	COG2205	protein histidine kinase activity
L6489_RS12800	COG0488	(ABC) transporter
L6489_RS12810	COG1136	(ABC) transporter
L6489_RS12815	COG0577	efflux transmembrane transporter activity
L6489_RS12840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6489_RS12850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6489_RS12965	COG2124	cytochrome p450
L6489_RS13000	COG0561	phosphatase activity
L6489_RS13005	COG5002	protein histidine kinase activity
L6489_RS13015	COG1819	glycosyl
L6489_RS13020	COG1794	racemase activity, acting on amino acids and derivatives
L6489_RS13045	COG2205	protein histidine kinase activity
L6489_RS13055	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6489_RS13060	COG0604	alcohol dehydrogenase
L6489_RS13065	COG0671	phosphoesterase, PA-phosphatase related
L6489_RS13070	COG0768	penicillin binding
L6489_RS13080	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS13090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6489_RS13130	COG0693	protein deglycase activity
L6489_RS13155	COG2814	Major facilitator Superfamily
L6489_RS13170	COG0584	glycerophosphoryl diester phosphodiesterase
L6489_RS13190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6489_RS13195	COG0697	spore germination
L6489_RS13215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6489_RS13225	COG2223	nitrite transmembrane transporter activity
L6489_RS13240	COG2816	NAD+ diphosphatase activity
L6489_RS13245	COG0592	DNA-directed DNA polymerase activity
L6489_RS13250	COG1051	belongs to the nudix hydrolase family
L6489_RS13280	COG3878	Protein conserved in bacteria
L6489_RS13305	COG4667	esterase of the alpha-beta hydrolase superfamily
L6489_RS13330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6489_RS13345	COG0322	excinuclease ABC activity
L6489_RS13385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6489_RS13410	COG1011	Hydrolase
L6489_RS13430	COG1523	belongs to the glycosyl hydrolase 13 family
L6489_RS13435	COG3227	Zinc metalloprotease (Elastase)
L6489_RS13455	COG0201	protein transport
L6489_RS13465	COG0697	spore germination
L6489_RS13470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6489_RS13505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6489_RS13520	COG2959	enzyme of heme biosynthesis
L6489_RS13550	COG3844	kynureninase activity
L6489_RS13555	COG1309	transcriptional regulator
L6489_RS13585	COG3284	Transcriptional regulator
L6489_RS13605	COG1349	DNA-binding transcription factor activity
L6489_RS13615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6489_RS13620	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6489_RS13625	COG0022	dehydrogenase e1 component
L6489_RS13630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6489_RS13640	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS13655	COG1051	belongs to the nudix hydrolase family
L6489_RS13675	COG4176	ABC-type proline glycine betaine transport system permease component
L6489_RS13680	COG4175	Glycine betaine
L6489_RS13680	COG0517	IMP dehydrogenase activity
L6489_RS13705	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L6489_RS13710	COG2153	protein acetylation
L6489_RS13715	COG3397	chitin binding
L6489_RS13730	COG2205	protein histidine kinase activity
L6489_RS13735	COG2226	methyltransferase
L6489_RS13740	COG2315	Protein conserved in bacteria
L6489_RS13745	COG2153	protein acetylation
L6489_RS13800	COG3973	AAA domain
L6489_RS13820	COG0514	ATP-dependent DNA helicase (RecQ)
L6489_RS13840	COG4637	Psort location Cytoplasmic, score
L6489_RS13865	COG3397	chitin binding
L6489_RS13880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6489_RS13885	COG1115	amino acid carrier protein
L6489_RS13950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6489_RS13960	COG3938	Belongs to the proline racemase family
L6489_RS13965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6489_RS14005	COG0586	Pfam SNARE associated Golgi protein
L6489_RS14020	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6489_RS14025	COG0519	Catalyzes the synthesis of GMP from XMP
L6489_RS14030	COG4166	transmembrane transport
L6489_RS14040	COG4948	Mandelate Racemase Muconate Lactonizing
L6489_RS14080	COG2936	dipeptidyl-peptidase activity
L6489_RS14085	COG5002	protein histidine kinase activity
L6489_RS14090	COG0745	RESPONSE REGULATOR receiver
L6489_RS14125	COG1164	Oligoendopeptidase f
L6489_RS14130	COG0531	amino acid
L6489_RS14135	COG1522	sequence-specific DNA binding
L6489_RS14140	COG1307	EDD domain protein, DegV family
L6489_RS14180	COG2814	Major facilitator Superfamily
L6489_RS14190	COG1664	Polymer-forming cytoskeletal
L6489_RS14195	COG0789	Transcriptional regulator
L6489_RS14200	COG4533	DNA binding
L6489_RS14205	COG0477	Major facilitator Superfamily
L6489_RS14205	COG2814	Major facilitator Superfamily
L6489_RS14225	COG2261	transglycosylase associated protein
L6489_RS14240	COG2226	methyltransferase
L6489_RS14275	COG0436	Aminotransferase
L6489_RS14280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L6489_RS14285	COG5146	pantothenate kinase activity
L6489_RS14290	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
L6489_RS14305	COG1131	(ABC) transporter
L6489_RS14355	COG0628	permease
L6489_RS14370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6489_RS14375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6489_RS14380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6489_RS14395	COG2816	NAD+ diphosphatase activity
L6489_RS14415	COG2746	aminoglycoside 3-N-acetyltransferase activity
L6489_RS14440	COG0697	spore germination
L6489_RS14445	COG2318	DinB family
L6489_RS14450	COG0454	-acetyltransferase
L6489_RS14465	COG4912	Dna alkylation repair
L6489_RS14485	COG0861	Integral membrane protein TerC family
L6489_RS14490	COG1368	sulfuric ester hydrolase activity
L6489_RS14495	COG0488	(ABC) transporter
L6489_RS14505	COG1033	growth of symbiont in host cell
L6489_RS14505	COG2409	Drug exporters of the RND superfamily
L6489_RS14510	COG1309	transcriptional regulator
L6489_RS14530	COG0287	Prephenate dehydrogenase
L6489_RS14535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6489_RS14545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L6489_RS14545	COG1605	Chorismate mutase
L6489_RS14580	COG3584	3D domain protein
L6489_RS14580	COG1388	LysM domain
L6489_RS14590	COG1595	DNA-templated transcription, initiation
L6489_RS14615	COG1879	ABC-type sugar transport system periplasmic component
L6489_RS14625	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6489_RS14685	COG2390	Transcriptional regulator
L6489_RS14690	COG1070	Carbohydrate kinase
L6489_RS14720	COG2329	Antibiotic biosynthesis monooxygenase
L6489_RS14740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6489_RS14755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6489_RS14760	COG4187	Peptidase family M20/M25/M40
L6489_RS14765	COG1414	Transcriptional regulator
L6489_RS14770	COG0833	amino acid
L6489_RS14775	COG1690	Belongs to the RtcB family
L6489_RS14780	COG3239	Fatty acid desaturase
L6489_RS14785	COG1785	Belongs to the alkaline phosphatase family
L6489_RS14795	COG3655	Transcriptional regulator
L6489_RS14810	COG4377	Putative membrane peptidase family (DUF2324)
L6489_RS14820	COG3279	Response regulator of the LytR AlgR family
L6489_RS14830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6489_RS14835	COG0346	lactoylglutathione lyase activity
L6489_RS14860	COG0714	Associated with various cellular activities
L6489_RS14885	COG0463	Glycosyl transferase, family 2
L6489_RS14905	COG0463	Glycosyl transferase, family 2
L6489_RS14915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6489_RS14920	COG0753	catalase activity
L6489_RS14930	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L6489_RS14940	COG1280	lysine exporter protein (LysE YggA)
L6489_RS14965	COG0714	Associated with various cellular activities
L6489_RS15090	COG0778	Nitroreductase
L6489_RS15095	COG1846	Transcriptional regulator
L6489_RS15130	COG1725	Transcriptional regulator
L6489_RS15150	COG1136	(ABC) transporter
L6489_RS15150	COG0577	efflux transmembrane transporter activity
L6489_RS15175	COG2207	Transcriptional regulator
L6489_RS15180	COG0456	acetyltransferase
L6489_RS15195	COG0697	spore germination
L6489_RS15200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6489_RS15245	COG0730	response to heat
L6489_RS15255	COG0833	amino acid
L6489_RS15265	COG4335	DNA alkylation repair
L6489_RS15300	COG0768	penicillin binding
L6489_RS15335	COG1984	allophanate hydrolase subunit 2
L6489_RS15340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L6489_RS15345	COG1414	Transcriptional regulator
L6489_RS15365	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6489_RS15370	COG0640	Transcriptional regulator
L6489_RS15380	COG1960	acyl-CoA dehydrogenase activity
L6489_RS15395	COG3314	Sporulation integral membrane protein YlbJ
L6489_RS15420	COG0574	Belongs to the PEP-utilizing enzyme family
L6489_RS15420	COG3848	Pyruvate phosphate dikinase
L6489_RS15425	COG1819	glycosyl
L6489_RS15430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6489_RS15445	COG5577	PFAM Coat F domain
L6489_RS15450	COG3403	YqcI/YcgG family
L6489_RS15455	COG1280	lysine exporter protein (LysE YggA)
L6489_RS15460	COG1113	amino acid transport
L6489_RS15490	COG1063	alcohol dehydrogenase
L6489_RS15525	COG4974	Belongs to the 'phage' integrase family
L6489_RS15605	COG0753	catalase activity
L6489_RS15610	COG0598	Magnesium transport protein CorA
L6489_RS15650	COG0415	Belongs to the DNA photolyase family
L6489_RS15655	COG0288	reversible hydration of carbon dioxide
L6489_RS15665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6489_RS15670	COG5609	conserved protein (DUF2294)
L6489_RS15685	COG0714	Associated with various cellular activities
L6489_RS15695	COG1575	Belongs to the MenA family. Type 1 subfamily
L6489_RS15705	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6489_RS15710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6489_RS15715	COG1121	(ABC) transporter
L6489_RS15730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6489_RS15740	COG0798	PFAM Bile acid sodium symporter
L6489_RS15745	COG0346	lactoylglutathione lyase activity
L6489_RS15750	COG0640	Transcriptional regulator
L6489_RS15760	COG0456	acetyltransferase
L6489_RS15770	COG3320	Male sterility
L6489_RS15770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6489_RS15775	COG1309	transcriptional regulator
L6489_RS15780	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS15785	COG1522	sequence-specific DNA binding
L6489_RS15800	COG0346	lactoylglutathione lyase activity
L6489_RS15840	COG2814	Major facilitator Superfamily
L6489_RS15865	COG0745	RESPONSE REGULATOR receiver
L6489_RS15870	COG3850	Histidine kinase
L6489_RS15870	COG5002	protein histidine kinase activity
L6489_RS15895	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L6489_RS15915	COG1476	TRANSCRIPTIONal
L6489_RS15940	COG0789	Transcriptional regulator
L6489_RS15945	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L6489_RS15960	COG1136	(ABC) transporter
L6489_RS15965	COG0577	efflux transmembrane transporter activity
L6489_RS15980	COG3850	Histidine kinase
L6489_RS15980	COG5002	protein histidine kinase activity
L6489_RS15990	COG2364	Membrane
L6489_RS15995	COG1846	Transcriptional regulator
L6489_RS16000	COG0456	acetyltransferase
L6489_RS16005	COG2808	Putative FMN-binding domain
L6489_RS16010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6489_RS16015	COG2271	Major facilitator Superfamily
L6489_RS16020	COG1556	Lactate utilization protein
L6489_RS16025	COG1139	Iron-sulfur cluster binding protein
L6489_RS16035	COG0583	DNA-binding transcription factor activity
L6489_RS16055	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6489_RS16070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6489_RS16090	COG1595	DNA-templated transcription, initiation
L6489_RS16105	COG0662	Cupin 2, conserved barrel domain protein
L6489_RS16110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6489_RS16110	COG2207	Transcriptional regulator
L6489_RS16125	COG3409	Peptidoglycan-binding domain 1 protein
L6489_RS16125	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6489_RS16415	COG2373	Large extracellular alpha-helical protein
L6489_RS16435	COG0477	Major facilitator Superfamily
L6489_RS16445	COG1846	Transcriptional regulator
L6489_RS16450	COG2814	Major facilitator Superfamily
L6489_RS16460	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6489_RS16465	COG1131	(ABC) transporter
L6489_RS16485	COG2076	Multidrug Resistance protein
L6489_RS16490	COG1309	transcriptional regulator
L6489_RS16500	COG1476	TRANSCRIPTIONal
L6489_RS16515	COG2031	fatty acid transporter
L6489_RS16525	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6489_RS16560	COG1122	ATPase activity
L6489_RS16570	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6489_RS16585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6489_RS16590	COG1288	antiporter activity
L6489_RS16600	COG3409	Peptidoglycan-binding domain 1 protein
L6489_RS16600	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6489_RS16610	COG3620	sequence-specific DNA binding
L6489_RS16620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L6489_RS16640	COG1733	regulation of RNA biosynthetic process
L6489_RS16645	COG0778	Nitroreductase
L6489_RS16665	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS16675	COG1131	(ABC) transporter
L6489_RS16700	COG1011	Hydrolase
L6489_RS16710	COG2365	Tyrosine phosphatase family
L6489_RS16735	COG0346	lactoylglutathione lyase activity
L6489_RS16740	COG1940	carbohydrate kinase activity
L6489_RS16750	COG0110	maltose O-acetyltransferase activity
L6489_RS16760	COG1136	(ABC) transporter
L6489_RS16760	COG0577	efflux transmembrane transporter activity
L6489_RS16780	COG0628	permease
L6489_RS16800	COG2226	methyltransferase
L6489_RS16810	COG0477	Major facilitator Superfamily
L6489_RS16840	COG1253	flavin adenine dinucleotide binding
L6489_RS16845	COG0789	Transcriptional regulator
L6489_RS16855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L6489_RS16885	COG0697	spore germination
L6489_RS16890	COG1357	PFAM Pentapeptide repeats (8 copies)
L6489_RS16895	COG3813	Protein conserved in bacteria
L6489_RS16905	COG2706	6-phosphogluconolactonase activity
L6489_RS16920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L6489_RS16925	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L6489_RS16935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L6489_RS16950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6489_RS16965	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS17010	COG0814	amino acid
L6489_RS17040	COG1393	Belongs to the ArsC family
L6489_RS17045	COG1733	regulation of RNA biosynthetic process
L6489_RS17050	COG2188	Transcriptional regulator
L6489_RS17055	COG0673	inositol 2-dehydrogenase activity
L6489_RS17060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L6489_RS17065	COG1733	regulation of RNA biosynthetic process
L6489_RS17070	COG1733	regulation of RNA biosynthetic process
L6489_RS17090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6489_RS17135	COG0318	PFAM AMP-dependent synthetase and ligase
L6489_RS17140	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6489_RS17145	COG1733	regulation of RNA biosynthetic process
L6489_RS17175	COG1191	sigma factor activity
L6489_RS17195	COG1309	transcriptional regulator
L6489_RS17215	COG3152	Membrane
L6489_RS17240	COG1151	hydroxylamine reductase activity
L6489_RS17250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6489_RS17255	COG3757	hydrolase, family 25
L6489_RS17255	COG3409	Peptidoglycan-binding domain 1 protein
L6489_RS17290	COG2072	flavoprotein involved in K transport
L6489_RS17325	COG1113	amino acid transport
L6489_RS17330	COG2814	Major facilitator Superfamily
L6489_RS17360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6489_RS17365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6489_RS17370	COG3328	transposase activity
L6489_RS17385	COG3739	integral membrane protein
L6489_RS17390	COG0384	phenazine biosynthesis protein PhzF
L6489_RS17420	COG0583	DNA-binding transcription factor activity
L6489_RS17440	COG1193	negative regulation of DNA recombination
L6489_RS17455	COG2162	N-hydroxyarylamine O-acetyltransferase activity
L6489_RS17460	COG1164	Oligoendopeptidase f
L6489_RS17470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6489_RS17495	COG0584	glycerophosphoryl diester phosphodiesterase
L6489_RS17520	COG0640	Transcriptional regulator
L6489_RS17525	COG0604	alcohol dehydrogenase
L6489_RS17535	COG0457	Tetratricopeptide repeat
L6489_RS17545	COG2808	Putative FMN-binding domain
L6489_RS17555	COG0456	acetyltransferase
L6489_RS17555	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6489_RS17565	COG0385	Bile acid
L6489_RS17570	COG0277	FAD linked oxidase domain protein
L6489_RS17600	COG1216	Glycosyl transferase, family 2
L6489_RS17605	COG1024	Enoyl-CoA hydratase
L6489_RS17615	COG1285	pathogenesis
L6489_RS17630	COG2514	catechol 2,3-dioxygenase activity
L6489_RS17635	COG2720	vancomycin resistance protein
L6489_RS17675	COG0716	FMN binding
L6489_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS17715	COG0165	Argininosuccinate lyase
L6489_RS17730	COG4145	pantothenate transmembrane transporter activity
L6489_RS17790	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS17800	COG1657	PFAM Prenyltransferase squalene oxidase
L6489_RS17805	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
L6489_RS17810	COG2962	Rard protein
L6489_RS17815	COG3326	Membrane
L6489_RS17830	COG0489	protein tyrosine kinase activity
L6489_RS17840	COG0314	molybdopterin synthase activity
L6489_RS17845	COG0303	'Molybdopterin
L6489_RS17850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6489_RS17855	COG2116	formate transmembrane transporter activity
L6489_RS17865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6489_RS17870	COG5609	conserved protein (DUF2294)
L6489_RS17875	COG2427	Protein of unknown function (DUF1641)
L6489_RS17880	COG3383	formate dehydrogenase (NAD+) activity
L6489_RS17885	COG0697	spore germination
L6489_RS17925	COG2226	methyltransferase
L6489_RS17930	COG4166	transmembrane transport
L6489_RS17940	COG4166	transmembrane transport
L6489_RS17945	COG4166	transmembrane transport
L6489_RS17950	COG1301	dicarboxylic acid transport
L6489_RS17955	COG1316	TRANSCRIPTIONal
L6489_RS17965	COG1595	DNA-templated transcription, initiation
L6489_RS17980	COG1131	(ABC) transporter
L6489_RS18005	COG0673	inositol 2-dehydrogenase activity
L6489_RS18015	COG0187	DNA topoisomerase II activity
L6489_RS18020	COG1832	CoA-binding protein
L6489_RS18025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6489_RS18030	COG0745	RESPONSE REGULATOR receiver
L6489_RS18050	COG4841	protein insertion into membrane
L6489_RS18055	COG0824	Thioesterase
L6489_RS18085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6489_RS18095	COG1132	(ABC) transporter
L6489_RS18100	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L6489_RS18140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6489_RS18155	COG0183	Belongs to the thiolase family
L6489_RS18160	COG0318	PFAM AMP-dependent synthetase and ligase
L6489_RS18165	COG1268	BioY protein
L6489_RS18170	COG0318	PFAM AMP-dependent synthetase and ligase
L6489_RS18230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6489_RS18245	COG0400	carboxylic ester hydrolase activity
L6489_RS18250	COG0346	lactoylglutathione lyase activity
L6489_RS18255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6489_RS18260	COG0069	glutamate synthase activity
L6489_RS18265	COG1902	pentaerythritol trinitrate reductase activity
L6489_RS18270	COG1329	Transcriptional regulator
L6489_RS18275	COG0010	Belongs to the arginase family
L6489_RS18300	COG2226	methyltransferase
L6489_RS18335	COG3344	reverse transcriptase
L6489_RS18345	COG4846	Membrane protein involved in cytochrome C biogenesis
L6489_RS18350	COG0785	Cytochrome C biogenesis protein
L6489_RS18360	COG1473	amidohydrolase
L6489_RS18370	COG1131	(ABC) transporter
L6489_RS18380	COG0583	DNA-binding transcription factor activity
L6489_RS18390	COG1346	cytolysis
L6489_RS18405	COG0730	response to heat
L6489_RS18430	COG1132	(ABC) transporter
L6489_RS18435	COG1132	(ABC) transporter
L6489_RS18465	COG3639	organic phosphonate transmembrane transporter activity
L6489_RS18470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L6489_RS18475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6489_RS18480	COG0737	Belongs to the 5'-nucleotidase family
L6489_RS18490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6489_RS18510	COG1695	Transcriptional regulator
L6489_RS18515	COG0174	glutamine synthetase
L6489_RS18520	COG0789	Transcriptional regulator
L6489_RS18525	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
L6489_RS18530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L6489_RS18535	COG2860	membrane
L6489_RS18540	COG0464	growth
L6489_RS18575	COG1388	LysM domain
L6489_RS18575	COG3584	3D domain protein
L6489_RS18580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6489_RS18580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6489_RS18580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6489_RS18585	COG1105	Belongs to the carbohydrate kinase PfkB family
L6489_RS18590	COG1349	DNA-binding transcription factor activity
L6489_RS18595	COG1979	alcohol dehydrogenase
L6489_RS18600	COG2322	membrane
L6489_RS18610	COG1113	amino acid transport
L6489_RS18620	COG1408	metallophosphoesterase
L6489_RS18625	COG2116	formate transmembrane transporter activity
L6489_RS18635	COG2217	Heavy metal translocating P-type atpase
L6489_RS18640	COG2608	mercury ion transmembrane transporter activity
L6489_RS18645	COG1937	Protein conserved in bacteria
L6489_RS18685	COG2819	hydrolase of the alpha beta superfamily
L6489_RS18690	COG1120	ATPase activity
L6489_RS18695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6489_RS18700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6489_RS18705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6489_RS18710	COG0708	Exodeoxyribonuclease III
L6489_RS18715	COG2169	Transcriptional regulator
L6489_RS18720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6489_RS18725	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L6489_RS18735	COG2364	Membrane
L6489_RS18750	COG2267	carboxylic ester hydrolase activity
L6489_RS18755	COG0346	lactoylglutathione lyase activity
L6489_RS18760	COG3300	MHYT domain
L6489_RS18760	COG5001	Diguanylate cyclase
L6489_RS18780	COG1380	Effector of murein hydrolase LrgA
L6489_RS18785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6489_RS18805	COG1404	Belongs to the peptidase S8 family
L6489_RS18810	COG3773	Cell wall hydrolase
L6489_RS18815	COG0562	UDP-galactopyranose mutase
L6489_RS18820	COG1368	sulfuric ester hydrolase activity
L6489_RS18825	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6489_RS18845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L6489_RS18850	COG2814	Major facilitator Superfamily
L6489_RS18860	COG0640	Transcriptional regulator
L6489_RS18880	COG4550	Control of competence regulator ComK, YlbF/YmcA
L6489_RS18890	COG1013	pyruvate-flavodoxin oxidoreductase activity
L6489_RS18895	COG0674	pyruvate-flavodoxin oxidoreductase activity
L6489_RS18895	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L6489_RS18905	COG2359	stage V sporulation protein S
L6489_RS18910	COG1692	metallophosphoesterase
L6489_RS18945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L6489_RS18950	COG1426	Protein conserved in bacteria
L6489_RS18965	COG0300	oxidoreductase activity
L6489_RS18970	COG0612	Peptidase, M16
L6489_RS18975	COG0612	Peptidase, M16
L6489_RS18980	COG1079	Belongs to the binding-protein-dependent transport system permease family
L6489_RS18985	COG4603	Belongs to the binding-protein-dependent transport system permease family
L6489_RS18990	COG3845	ABC transporter
L6489_RS18995	COG1744	ABC transporter substrate-binding protein PnrA-like
L6489_RS19000	COG2188	Transcriptional regulator
L6489_RS19005	COG1674	ftsk spoiiie
L6489_RS19015	COG0740	serine-type endopeptidase activity
L6489_RS19020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6489_RS19030	COG0527	aspartate kinase activity
L6489_RS19035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6489_RS19040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6489_RS19045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6489_RS19050	COG1873	PFAM PRC-barrel domain
L6489_RS19055	COG0612	Peptidase, M16
L6489_RS19060	COG0726	polysaccharide deacetylase
L6489_RS19075	COG0196	riboflavin kinase activity
L6489_RS19090	COG1550	Protein conserved in bacteria
L6489_RS19100	COG1358	cellular component organization or biogenesis
L6489_RS19105	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L6489_RS19110	COG0195	Participates in both transcription termination and antitermination
L6489_RS19140	COG0750	zinc metalloprotease
L6489_RS19150	COG4589	Belongs to the CDS family
L6489_RS19165	COG0528	UMP kinase activity
L6489_RS19195	COG4974	Belongs to the 'phage' integrase family
L6489_RS19205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6489_RS19210	COG0758	DNA mediated transformation
L6489_RS19215	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L6489_RS19255	COG1837	Belongs to the UPF0109 family
L6489_RS19265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L6489_RS19275	COG0552	protein localization to endoplasmic reticulum
L6489_RS19280	COG1196	nuclear chromosome segregation
L6489_RS19290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6489_RS19295	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS19300	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L6489_RS19315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L6489_RS19320	COG1461	Dihydroxyacetone kinase
L6489_RS19325	COG1302	Protein conserved in bacteria
L6489_RS19340	COG1564	THIamine pyrophosphokinase
L6489_RS19345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L6489_RS19350	COG1162	GTPase activity
L6489_RS19355	COG0515	serine threonine protein kinase
L6489_RS19355	COG2815	serine threonine protein kinase
L6489_RS19360	COG0631	protein serine/threonine phosphatase activity
L6489_RS19370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6489_RS19370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6489_RS19380	COG0242	peptide deformylase activity
L6489_RS19385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L6489_RS19390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6489_RS19410	COG1561	YicC-like family, N-terminal region
L6489_RS19415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L6489_RS19425	COG0006	proline dipeptidase activity
L6489_RS19445	COG3069	C4-dicarboxylate transmembrane transporter activity
L6489_RS19505	COG0564	pseudouridine synthase activity
L6489_RS19525	COG3599	regulation of cell shape
L6489_RS19530	COG2302	S4 RNA-binding domain
L6489_RS19535	COG0762	integral membrane protein
L6489_RS19545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L6489_RS19550	COG1496	oxidoreductase activity
L6489_RS19555	COG1873	PFAM PRC-barrel domain
L6489_RS19560	COG1191	sigma factor activity
L6489_RS19565	COG1191	sigma factor activity
L6489_RS19575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L6489_RS19580	COG0849	cell division
L6489_RS19585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L6489_RS19600	COG0772	Belongs to the SEDS family
L6489_RS19615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6489_RS19620	COG0768	penicillin binding
L6489_RS19625	COG0768	penicillin binding
L6489_RS19630	COG4839	cell division protein FtsL
L6489_RS19645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6489_RS19660	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L6489_RS19665	COG1399	metal-binding, possibly nucleic acid-binding protein
L6489_RS19675	COG3480	Lon protease (S16) C-terminal proteolytic domain
L6489_RS19680	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6489_RS19685	COG3314	Sporulation integral membrane protein YlbJ
L6489_RS19695	COG0742	ribosomal rna small subunit methyltransferase
L6489_RS19710	COG3679	Belongs to the UPF0342 family
L6489_RS19715	COG0406	alpha-ribazole phosphatase activity
L6489_RS19730	COG2340	Cysteine-rich secretory protein family
L6489_RS19745	COG3336	cytochrome c oxidase
L6489_RS19780	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L6489_RS19785	COG0772	Belongs to the SEDS family
L6489_RS19795	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L6489_RS19800	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L6489_RS19810	COG4896	Protein conserved in bacteria
L6489_RS19825	COG1217	gtp-binding protein TYPA
L6489_RS19835	COG0483	inositol monophosphate 1-phosphatase activity
L6489_RS19855	COG1982	Orn Lys Arg decarboxylase major
L6489_RS19905	COG0022	dehydrogenase e1 component
L6489_RS19910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6489_RS19920	COG0242	peptide deformylase activity
L6489_RS19925	COG0561	phosphatase activity
L6489_RS19935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6489_RS19940	COG0569	domain protein
L6489_RS19960	COG0583	DNA-binding transcription factor activity
L6489_RS19965	COG0517	IMP dehydrogenase activity
L6489_RS19975	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
L6489_RS19985	COG4703	Protein of unknown function (DUF1797)
L6489_RS20000	COG2200	EAL domain
L6489_RS20005	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS20010	COG1408	metallophosphoesterase
L6489_RS20020	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L6489_RS20055	COG2814	Major facilitator Superfamily
L6489_RS20075	COG3209	COG3209 Rhs family protein
L6489_RS20085	COG2205	protein histidine kinase activity
L6489_RS20095	COG0436	Aminotransferase
L6489_RS20100	COG1609	Transcriptional regulator
L6489_RS20105	COG3833	ABC-type maltose transport systems, permease component
L6489_RS20110	COG1175	transmembrane transport
L6489_RS20115	COG2182	Extracellular solute-binding protein
L6489_RS20125	COG0366	Alpha amylase catalytic
L6489_RS20130	COG3842	ATPase activity
L6489_RS20170	COG0183	Belongs to the thiolase family
L6489_RS20210	COG1695	Transcriptional regulator
L6489_RS20215	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS20235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L6489_RS20240	COG0436	Aminotransferase
L6489_RS20275	COG2084	Dehydrogenase
L6489_RS20280	COG2199	diguanylate cyclase activity
L6489_RS20285	COG0778	Nitroreductase
L6489_RS20310	COG1263	PTS System
L6489_RS20310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6489_RS20310	COG2190	(PTS) system
L6489_RS20315	COG3711	transcriptional antiterminator
L6489_RS20325	COG2188	Transcriptional regulator
L6489_RS20335	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6489_RS20360	COG1547	Domain of unknown function (DUF309)
L6489_RS20365	COG0456	acetyltransferase
L6489_RS20375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L6489_RS20380	COG4086	secreted protein
L6489_RS20385	COG0561	phosphatase activity
L6489_RS20390	COG0697	spore germination
L6489_RS20405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6489_RS20430	COG0733	neurotransmitter:sodium symporter activity
L6489_RS20450	COG1686	Belongs to the peptidase S11 family
L6489_RS20455	COG1725	Transcriptional regulator
L6489_RS20460	COG1131	(ABC) transporter
L6489_RS20480	COG1846	Transcriptional regulator
L6489_RS20495	COG0598	Magnesium transport protein CorA
L6489_RS20520	COG4974	Belongs to the 'phage' integrase family
L6489_RS20530	COG0735	belongs to the Fur family
L6489_RS20535	COG1300	Membrane
L6489_RS20555	COG0667	Aldo Keto reductase
L6489_RS20560	COG0656	L-ascorbic acid biosynthetic process
L6489_RS20565	COG0456	acetyltransferase
L6489_RS20565	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6489_RS20575	COG4085	toxin activity
L6489_RS20575	COG1525	nuclease
L6489_RS20575	COG0737	Belongs to the 5'-nucleotidase family
L6489_RS20585	COG0596	Alpha beta hydrolase
L6489_RS20590	COG2056	Na+-H+ antiporter family
L6489_RS20595	COG1609	Transcriptional regulator
L6489_RS20600	COG0454	-acetyltransferase
L6489_RS20605	COG1073	alpha beta
L6489_RS20620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6489_RS20620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6489_RS20625	COG0307	riboflavin synthase, alpha
L6489_RS20650	COG4106	trans-aconitate 2-methyltransferase activity
L6489_RS20655	COG2226	methyltransferase
L6489_RS20655	COG1073	alpha beta
L6489_RS20670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6489_RS20680	COG1757	Na H antiporter
L6489_RS20685	COG0737	Belongs to the 5'-nucleotidase family
L6489_RS20695	COG1522	sequence-specific DNA binding
L6489_RS20715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6489_RS20740	COG0300	oxidoreductase activity
L6489_RS20745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6489_RS20750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6489_RS20755	COG1760	l-serine dehydratase
L6489_RS20760	COG1760	l-serine dehydratase
L6489_RS20780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6489_RS20790	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6489_RS20795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6489_RS20810	COG1376	ErfK ybiS ycfS ynhG family protein
L6489_RS20815	COG4129	membrane
L6489_RS20820	COG1126	abc transporter atp-binding protein
L6489_RS20825	COG0765	amino acid transport
L6489_RS20830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6489_RS20840	COG2816	NAD+ diphosphatase activity
L6489_RS20845	COG0772	Belongs to the SEDS family
L6489_RS20850	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6489_RS20855	COG0022	dehydrogenase e1 component
L6489_RS20860	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6489_RS20865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6489_RS20880	COG0280	phosphate acetyltransferase
L6489_RS20885	COG3290	protein histidine kinase activity
L6489_RS20885	COG3829	transcription factor binding
L6489_RS20895	COG0584	glycerophosphoryl diester phosphodiesterase
L6489_RS20900	COG3093	addiction module antidote protein HigA
L6489_RS20910	COG0745	RESPONSE REGULATOR receiver
L6489_RS20915	COG0750	zinc metalloprotease
L6489_RS20920	COG0497	DNA recombination
L6489_RS20930	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L6489_RS20940	COG0142	geranyltranstransferase activity
L6489_RS20965	COG1302	Protein conserved in bacteria
L6489_RS20970	COG0439	Biotin carboxylase
L6489_RS20975	COG0511	ligase activity, forming carbon-carbon bonds
L6489_RS21020	COG3854	ATPases associated with a variety of cellular activities
L6489_RS21045	COG0006	proline dipeptidase activity
L6489_RS21060	COG3872	metal-dependent enzyme
L6489_RS21070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6489_RS21105	COG0095	Lipoate-protein ligase
L6489_RS21110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6489_RS21115	COG1609	Transcriptional regulator
L6489_RS21125	COG2076	Multidrug Resistance protein
L6489_RS21130	COG2076	Multidrug Resistance protein
L6489_RS21165	COG1131	(ABC) transporter
L6489_RS21170	COG1725	Transcriptional regulator
L6489_RS21200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6489_RS21255	COG4970	Tfp pilus assembly protein FimT
L6489_RS21265	COG1459	type II secretion system
L6489_RS21270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6489_RS21320	COG1410	methionine synthase
L6489_RS21320	COG0646	methionine synthase
L6489_RS21325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L6489_RS21325	COG0646	methionine synthase
L6489_RS21330	COG0626	cystathionine gamma-synthase activity
L6489_RS21335	COG0626	cystathionine gamma-synthase activity
L6489_RS21355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6489_RS21365	COG1940	carbohydrate kinase activity
L6489_RS21370	COG4483	Protein conserved in bacteria
L6489_RS21375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L6489_RS21380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L6489_RS21385	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L6489_RS21390	COG0704	Plays a role in the regulation of phosphate uptake
L6489_RS21400	COG0581	inorganic phosphate transmembrane transporter activity
L6489_RS21405	COG0573	inorganic phosphate transmembrane transporter activity
L6489_RS21410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6489_RS21420	COG0768	penicillin binding
L6489_RS21425	COG0477	Major facilitator Superfamily
L6489_RS21430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6489_RS21455	COG0735	belongs to the Fur family
L6489_RS21460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6489_RS21465	COG1121	(ABC) transporter
L6489_RS21470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6489_RS21500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6489_RS21505	COG2384	SAM-dependent methyltransferase
L6489_RS21510	COG2010	Cytochrome c
L6489_RS21515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L6489_RS21520	COG0358	DNA primase activity
L6489_RS21530	COG0517	IMP dehydrogenase activity
L6489_RS21545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L6489_RS21550	COG0295	cytidine deaminase activity
L6489_RS21555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L6489_RS21565	COG1480	7TM receptor with intracellular HD hydrolase
L6489_RS21570	COG1702	phosphate starvation-inducible protein PhoH
L6489_RS21585	COG1610	YqeY-like protein
L6489_RS21590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L6489_RS21595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6489_RS21600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L6489_RS21630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6489_RS21635	COG1733	regulation of RNA biosynthetic process
L6489_RS21660	COG1466	dna polymerase III delta subunit
L6489_RS21670	COG0658	competence protein
L6489_RS21670	COG2333	competence protein COMEC
L6489_RS21675	COG2131	deaminase
L6489_RS21680	COG1555	photosystem II stabilization
L6489_RS21680	COG1596	polysaccharide export
L6489_RS21685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6489_RS21690	COG2226	methyltransferase
L6489_RS21695	COG0799	negative regulation of ribosome biogenesis
L6489_RS21700	COG1713	HD superfamily hydrolase involved in NAD metabolism
L6489_RS21710	COG1534	Rna-binding protein
L6489_RS21720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L6489_RS21725	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
L6489_RS21750	COG1595	DNA-templated transcription, initiation
L6489_RS21760	COG0778	Nitroreductase
L6489_RS21765	COG2357	RelA SpoT domain protein
L6489_RS21775	COG1785	Belongs to the alkaline phosphatase family
L6489_RS21785	COG2267	carboxylic ester hydrolase activity
L6489_RS21820	COG1404	Belongs to the peptidase S8 family
L6489_RS21825	COG3186	Phenylalanine-4-hydroxylase
L6489_RS21835	COG2514	catechol 2,3-dioxygenase activity
L6489_RS21840	COG2259	Doxx family
L6489_RS21880	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L6489_RS21890	COG1454	alcohol dehydrogenase
L6489_RS21890	COG1012	belongs to the aldehyde dehydrogenase family
L6489_RS21895	COG0626	cystathionine gamma-synthase activity
L6489_RS21900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6489_RS21925	COG0768	penicillin binding
L6489_RS21940	COG0826	peptidase U32
L6489_RS21945	COG0826	peptidase U32
L6489_RS21950	COG4122	O-methyltransferase activity
L6489_RS21955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L6489_RS21985	COG0628	permease
L6489_RS22005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6489_RS22020	COG1104	cysteine desulfurase activity
L6489_RS22025	COG1959	2 iron, 2 sulfur cluster binding
L6489_RS22030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L6489_RS22040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L6489_RS22075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6489_RS22085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L6489_RS22085	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L6489_RS22090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6489_RS22095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6489_RS22095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6489_RS22105	COG2244	polysaccharide biosynthetic process
L6489_RS22110	COG2323	membrane
L6489_RS22120	COG1862	Preprotein translocase
L6489_RS22150	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L6489_RS22160	COG0697	spore germination
L6489_RS22165	COG0640	Transcriptional regulator
L6489_RS22190	COG0157	Belongs to the NadC ModD family
L6489_RS22195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L6489_RS22200	COG1104	cysteine desulfurase activity
L6489_RS22205	COG1827	regulation of RNA biosynthetic process
L6489_RS22210	COG2258	MOSC domain
L6489_RS22215	COG0077	Prephenate dehydratase
L6489_RS22220	COG0577	efflux transmembrane transporter activity
L6489_RS22225	COG0577	efflux transmembrane transporter activity
L6489_RS22230	COG1136	(ABC) transporter
L6489_RS22235	COG5002	protein histidine kinase activity
L6489_RS22240	COG0745	RESPONSE REGULATOR receiver
L6489_RS22250	COG3290	protein histidine kinase activity
L6489_RS22260	COG2868	ribosomal protein
L6489_RS22265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L6489_RS22270	COG1530	ribonuclease E activity
L6489_RS22275	COG1994	Peptidase M50
L6489_RS22280	COG0739	heme binding
L6489_RS22285	COG2894	cell division
L6489_RS22305	COG1077	Cell shape determining protein MreB Mrl
L6489_RS22345	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L6489_RS22345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L6489_RS22470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L6489_RS22510	COG0285	dihydrofolate synthase activity
L6489_RS22525	COG1388	LysM domain
L6489_RS22535	COG0113	porphobilinogen synthase activity
L6489_RS22540	COG1587	Uroporphyrinogen-III synthase
L6489_RS22550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6489_RS22560	COG1846	Transcriptional regulator
L6489_RS22565	COG1764	response to oxidative stress
L6489_RS22580	COG0470	DNA polymerase III
L6489_RS22580	COG1067	ATP-dependent peptidase activity
L6489_RS22630	COG0622	Phosphoesterase
L6489_RS22645	COG5401	PFAM Sporulation and spore germination
L6489_RS22660	COG2197	response regulator
L6489_RS22665	COG2233	PERMEase
L6489_RS22670	COG0402	S-adenosylhomocysteine deaminase activity
L6489_RS22675	COG1983	PspC domain protein
L6489_RS22680	COG1396	sequence-specific DNA binding
L6489_RS22685	COG0697	spore germination
L6489_RS22695	COG1959	2 iron, 2 sulfur cluster binding
L6489_RS22700	COG1668	transmembrane transport
L6489_RS22705	COG4152	abc transporter atp-binding protein
L6489_RS22710	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L6489_RS22715	COG1360	Flagellar Motor Protein
L6489_RS22720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6489_RS22725	COG1876	peptidase activity
L6489_RS22730	COG0824	Thioesterase
L6489_RS22735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L6489_RS22740	COG1053	succinate dehydrogenase
L6489_RS22745	COG2009	succinate dehydrogenase
L6489_RS22750	COG1719	4-vinyl reductase, 4VR
L6489_RS22760	COG3118	belongs to the thioredoxin family
L6489_RS22765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L6489_RS22770	COG2086	electron transfer activity
L6489_RS22775	COG1024	Enoyl-CoA hydratase
L6489_RS22780	COG1309	transcriptional regulator
L6489_RS22785	COG0318	PFAM AMP-dependent synthetase and ligase
L6489_RS22805	COG2318	DinB family
L6489_RS22830	COG1131	(ABC) transporter
L6489_RS22835	COG2205	protein histidine kinase activity
L6489_RS22840	COG0745	RESPONSE REGULATOR receiver
L6489_RS22850	COG4895	conserved protein (DUF2196)
L6489_RS22855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L6489_RS22870	COG4509	Sortase family
L6489_RS22875	COG1120	ATPase activity
L6489_RS22890	COG5386	Cell surface protein
L6489_RS22895	COG5386	Cell surface protein
L6489_RS22900	COG1114	Component of the transport system for branched-chain amino acids
L6489_RS22905	COG1187	pseudouridine synthase activity
L6489_RS22915	COG1796	DNA polymerase
L6489_RS22915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6489_RS22920	COG1286	toxin biosynthetic process
L6489_RS22965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6489_RS22975	COG1418	mRNA catabolic process
L6489_RS22985	COG2814	Major facilitator Superfamily
L6489_RS22990	COG1566	PFAM secretion protein HlyD family protein
L6489_RS22995	COG1309	transcriptional regulator
L6489_RS23000	COG1363	Peptidase, m42
L6489_RS23025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6489_RS23035	COG1484	DNA-dependent DNA replication
L6489_RS23040	COG3611	Membrane attachment protein
L6489_RS23050	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L6489_RS23055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6489_RS23060	COG0237	dephospho-CoA kinase activity
L6489_RS23065	COG1971	Probably functions as a manganese efflux pump
L6489_RS23075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6489_RS23075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6489_RS23080	COG5002	protein histidine kinase activity
L6489_RS23085	COG0745	RESPONSE REGULATOR receiver
L6489_RS23105	COG0538	isocitrate dehydrogenase activity
L6489_RS23110	COG0372	Belongs to the citrate synthase family
L6489_RS23120	COG0628	permease
L6489_RS23125	COG3030	protein affecting phage T7 exclusion by the F plasmid
L6489_RS23150	COG1725	Transcriptional regulator
L6489_RS23155	COG0281	malic enzyme
L6489_RS23160	COG0587	DNA-directed DNA polymerase activity
L6489_RS23175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L6489_RS23190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6489_RS23200	COG4109	DRTGG domain
L6489_RS23215	COG0006	proline dipeptidase activity
L6489_RS23250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6489_RS23255	COG0662	Cupin 2, conserved barrel domain protein
L6489_RS23270	COG1028	Short-chain dehydrogenase reductase Sdr
L6489_RS23275	COG0589	response to stress
L6489_RS23315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6489_RS23330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L6489_RS23335	COG0827	DNA restriction-modification system
L6489_RS23340	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L6489_RS23350	COG3874	Sporulation protein YtfJ
L6489_RS23365	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L6489_RS23375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6489_RS23390	COG1104	cysteine desulfurase activity
L6489_RS23400	COG0583	DNA-binding transcription factor activity
L6489_RS23405	COG0697	spore germination
L6489_RS23410	COG1309	transcriptional regulator
L6489_RS23415	COG1956	GAF domain-containing protein
L6489_RS23420	COG0626	cystathionine gamma-synthase activity
L6489_RS23465	COG1595	DNA-templated transcription, initiation
L6489_RS23475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6489_RS23480	COG0454	-acetyltransferase
L6489_RS23485	COG0517	IMP dehydrogenase activity
L6489_RS23490	COG0123	including yeast histone deacetylase and acetoin utilization protein
L6489_RS23495	COG2267	carboxylic ester hydrolase activity
L6489_RS23505	COG0745	RESPONSE REGULATOR receiver
L6489_RS23515	COG0666	response to abiotic stimulus
L6489_RS23520	COG0745	RESPONSE REGULATOR receiver
L6489_RS23520	COG2972	Histidine kinase
L6489_RS23575	COG1609	Transcriptional regulator
L6489_RS23580	COG4851	CamS sex pheromone cAM373 precursor
L6489_RS23585	COG3118	belongs to the thioredoxin family
L6489_RS23595	COG2309	aminopeptidase activity
L6489_RS23605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6489_RS23610	COG0697	spore germination
L6489_RS23615	COG0789	Transcriptional regulator
L6489_RS23620	COG1695	Transcriptional regulator
L6489_RS23640	COG1674	ftsk spoiiie
L6489_RS23640	COG1674	ftsk spoiiie
L6489_RS23650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6489_RS23660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6489_RS23665	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
L6489_RS23670	COG1363	Peptidase, m42
L6489_RS23680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6489_RS23695	COG0510	thiamine kinase activity
L6489_RS23700	COG1523	belongs to the glycosyl hydrolase 13 family
L6489_RS23710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6489_RS23715	COG1349	DNA-binding transcription factor activity
L6489_RS23720	COG1187	pseudouridine synthase activity
L6489_RS23725	COG2244	polysaccharide biosynthetic process
L6489_RS23730	COG2081	HI0933 family
L6489_RS23740	COG2814	Major facilitator Superfamily
L6489_RS23750	COG3832	glyoxalase III activity
L6489_RS23770	COG1329	Transcriptional regulator
L6489_RS23795	COG0314	molybdopterin synthase activity
L6489_RS23810	COG1763	Mo-molybdopterin cofactor biosynthetic process
L6489_RS23815	COG0303	'Molybdopterin
L6489_RS23825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6489_RS23830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L6489_RS23850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6489_RS23860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L6489_RS23905	COG2814	Major facilitator Superfamily
L6489_RS23915	COG0475	glutathione-regulated potassium exporter activity
L6489_RS23920	COG0490	domain, Protein
L6489_RS23925	COG0582	viral genome integration into host DNA
L6489_RS23935	COG1136	(ABC) transporter
L6489_RS23955	COG1242	4 iron, 4 sulfur cluster binding
L6489_RS23960	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L6489_RS23975	COG1794	racemase activity, acting on amino acids and derivatives
L6489_RS24000	COG2267	carboxylic ester hydrolase activity
L6489_RS24005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L6489_RS24010	COG0671	phosphoesterase, PA-phosphatase related
L6489_RS24015	COG0438	transferase activity, transferring glycosyl groups
L6489_RS24025	COG0521	Mo-molybdopterin cofactor biosynthetic process
L6489_RS24075	COG3328	transposase activity
L6489_RS24095	COG5002	protein histidine kinase activity
L6489_RS24105	COG2267	carboxylic ester hydrolase activity
L6489_RS24110	COG1368	sulfuric ester hydrolase activity
L6489_RS24125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6489_RS24130	COG1116	anion transmembrane transporter activity
L6489_RS24135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6489_RS24160	COG0494	nUDIX hydrolase
L6489_RS24190	COG0288	reversible hydration of carbon dioxide
L6489_RS24195	COG1271	oxidase subunit
L6489_RS24200	COG1294	oxidase, subunit
L6489_RS24220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6489_RS24245	COG1842	Phage shock protein A
L6489_RS24280	COG0745	RESPONSE REGULATOR receiver
L6489_RS24310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L6489_RS24315	COG1597	lipid kinase activity
L6489_RS24340	COG0586	Pfam SNARE associated Golgi protein
L6489_RS24350	COG4977	sequence-specific DNA binding
L6489_RS24360	COG0577	efflux transmembrane transporter activity
L6489_RS24365	COG1136	(ABC) transporter
L6489_RS24370	COG2207	Transcriptional regulator
L6489_RS24370	COG3708	Transcriptional regulator
L6489_RS24385	COG0745	RESPONSE REGULATOR receiver
L6489_RS24390	COG2205	protein histidine kinase activity
L6489_RS24395	COG0577	efflux transmembrane transporter activity
L6489_RS24400	COG0577	efflux transmembrane transporter activity
L6489_RS24405	COG1136	(ABC) transporter
L6489_RS24410	COG0577	efflux transmembrane transporter activity
L6489_RS24435	COG2188	Transcriptional regulator
L6489_RS24455	COG3964	amidohydrolase
L6489_RS24480	COG4948	Mandelate Racemase Muconate Lactonizing
L6489_RS24490	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L6489_RS24495	COG0596	Alpha beta hydrolase
L6489_RS24505	COG1169	isochorismate synthase
L6489_RS24510	COG1575	Belongs to the MenA family. Type 1 subfamily
L6489_RS24515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L6489_RS24630	COG0058	SHG alpha-glucan phosphorylase activity
L6489_RS24640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L6489_RS24660	COG1404	Belongs to the peptidase S8 family
L6489_RS24675	COG1595	DNA-templated transcription, initiation
L6489_RS24770	COG0544	peptidyl-prolyl cis-trans isomerase activity
L6489_RS24805	COG1285	pathogenesis
L6489_RS24810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6489_RS24825	COG2155	Conserved Protein
L6489_RS24830	COG1098	S1 RNA binding domain
L6489_RS24835	COG0436	Aminotransferase
L6489_RS24840	COG1522	sequence-specific DNA binding
L6489_RS24845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6489_RS24850	COG2267	carboxylic ester hydrolase activity
L6489_RS24860	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L6489_RS24880	COG5018	Exonuclease
L6489_RS24885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6489_RS24910	COG2050	protein possibly involved in aromatic compounds catabolism
L6489_RS24920	COG1268	BioY protein
L6489_RS24925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L6489_RS24930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L6489_RS24945	COG3584	3D domain protein
L6489_RS24960	COG1252	NADH dehydrogenase
L6489_RS24970	COG3708	Transcriptional regulator
L6489_RS24985	COG1683	Conserved Protein
L6489_RS24995	COG0316	Belongs to the HesB IscA family
L6489_RS25020	COG1252	NADH dehydrogenase
L6489_RS25030	COG2274	protein secretion by the type I secretion system
L6489_RS25035	COG0390	transport system, permease component
L6489_RS25040	COG3328	transposase activity
L6489_RS25045	COG2824	Alkylphosphonate utilization operon protein PhnA
L6489_RS25065	COG4837	Protein of unknown function (DUF1462)
L6489_RS25070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L6489_RS25080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6489_RS25085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L6489_RS25095	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6489_RS25100	COG0647	UMP catabolic process
L6489_RS25110	COG2445	Protein of unknown function DUF86
L6489_RS25115	COG1494	fructose-1,6-bisphosphatase
L6489_RS25130	COG4470	Protein conserved in bacteria
L6489_RS25140	COG0789	Transcriptional regulator
L6489_RS25145	COG4377	Putative membrane peptidase family (DUF2324)
L6489_RS25170	COG0739	heme binding
L6489_RS25180	COG3377	Domain of unknown function (DUF1805)
L6489_RS25185	COG0737	Belongs to the 5'-nucleotidase family
L6489_RS25190	COG0719	Fe-S assembly protein
L6489_RS25195	COG0822	iron-sulfur transferase activity
L6489_RS25200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L6489_RS25205	COG0719	Fe-S assembly protein
L6489_RS25210	COG0396	ATPase activity
L6489_RS25215	COG1464	Belongs to the NlpA lipoprotein family
L6489_RS25220	COG1464	Belongs to the NlpA lipoprotein family
L6489_RS25225	COG2011	ABC-type metal ion transport system permease component
L6489_RS25240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6489_RS25245	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6489_RS25255	COG1393	Belongs to the ArsC family
L6489_RS25320	COG1396	sequence-specific DNA binding
L6489_RS25330	COG1309	transcriptional regulator
L6489_RS25335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6489_RS25340	COG1960	acyl-CoA dehydrogenase activity
L6489_RS25345	COG0183	Belongs to the thiolase family
L6489_RS25350	COG1024	Enoyl-CoA hydratase
L6489_RS25350	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6489_RS25360	COG1686	Belongs to the peptidase S11 family
L6489_RS25375	COG0011	TIGRFAM Protein of
L6489_RS25380	COG0840	transmembrane signaling receptor activity
L6489_RS25395	COG2814	Major facilitator Superfamily
L6489_RS25400	COG0531	amino acid
L6489_RS25425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6489_RS25470	COG0586	Pfam SNARE associated Golgi protein
L6489_RS25480	COG1376	ErfK ybiS ycfS ynhG family protein
L6489_RS25485	COG0745	RESPONSE REGULATOR receiver
L6489_RS25490	COG5002	protein histidine kinase activity
L6489_RS25515	COG0840	transmembrane signaling receptor activity
L6489_RS25520	COG2151	metal-sulfur cluster biosynthetic enzyme
L6489_RS25525	COG3227	Zinc metalloprotease (Elastase)
L6489_RS25530	COG1741	Belongs to the pirin family
L6489_RS25545	COG0475	glutathione-regulated potassium exporter activity
L6489_RS25550	COG0490	domain, Protein
L6489_RS25555	COG1115	amino acid carrier protein
L6489_RS25560	COG0783	Belongs to the Dps family
L6489_RS25575	COG1611	Belongs to the LOG family
L6489_RS25590	COG2311	Membrane
L6489_RS25595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6489_RS25600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6489_RS25605	COG1115	amino acid carrier protein
L6489_RS25610	COG1115	amino acid carrier protein
L6489_RS25615	COG2910	NAD(P)H-binding
L6489_RS25640	COG0656	L-ascorbic acid biosynthetic process
L6489_RS25645	COG2814	Major facilitator Superfamily
L6489_RS25650	COG1733	regulation of RNA biosynthetic process
L6489_RS25660	COG1252	NADH dehydrogenase
L6489_RS25670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L6489_RS25685	COG0840	transmembrane signaling receptor activity
L6489_RS25685	COG3290	protein histidine kinase activity
L6489_RS25720	COG0488	(ABC) transporter
L6489_RS25725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6489_RS25735	COG2814	Major facilitator Superfamily
L6489_RS25785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6489_RS25790	COG0697	spore germination
L6489_RS25810	COG0557	exoribonuclease II activity
L6489_RS25815	COG1647	Serine aminopeptidase, S33
L6489_RS25820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6489_RS25825	COG1346	cytolysis
L6489_RS25860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6489_RS25875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L6489_RS25900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6489_RS25915	COG2323	membrane
L6489_RS25925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6489_RS25935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L6489_RS25945	COG1051	belongs to the nudix hydrolase family
L6489_RS25955	COG0492	ferredoxin-NADP+ reductase activity
L6489_RS25960	COG0457	Tetratricopeptide repeat
L6489_RS25965	COG0110	maltose O-acetyltransferase activity
L6489_RS25985	COG1950	PFAM Membrane protein of
L6489_RS25995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6489_RS26000	COG0556	nucleotide-excision repair
L6489_RS26015	COG0789	Transcriptional regulator
L6489_RS26040	COG2855	membrane
L6489_RS26045	COG0583	DNA-binding transcription factor activity
L6489_RS26055	COG0655	NAD(P)H dehydrogenase (quinone) activity
L6489_RS26060	COG0488	(ABC) transporter
L6489_RS26070	COG1132	(ABC) transporter
L6489_RS26080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6489_RS26085	COG0793	Belongs to the peptidase S41A family
L6489_RS26085	COG3409	Peptidoglycan-binding domain 1 protein
L6489_RS26090	COG2177	Part of the ABC transporter FtsEX involved in
L6489_RS26095	COG2884	Cell division ATP-binding protein ftsE
L6489_RS26115	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L6489_RS26120	COG1278	Cold shock
L6489_RS26125	COG1040	competence protein
L6489_RS26130	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L6489_RS26140	COG1733	regulation of RNA biosynthetic process
L6489_RS26145	COG1307	EDD domain protein, DegV family
L6489_RS26150	COG1739	Uncharacterized protein family UPF0029
L6489_RS26155	COG1316	TRANSCRIPTIONal
L6489_RS26160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L6489_RS26165	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L6489_RS26170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L6489_RS26180	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L6489_RS26180	COG3933	PFAM sigma-54 factor interaction domain-containing protein
L6489_RS26200	COG1486	melibiose metabolic process
L6489_RS26205	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6489_RS26210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6489_RS26220	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L6489_RS26240	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6489_RS26250	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6489_RS26255	COG1301	dicarboxylic acid transport
L6489_RS26265	COG0346	lactoylglutathione lyase activity
L6489_RS26285	COG1511	domain protein
L6489_RS26290	COG0583	DNA-binding transcription factor activity
L6489_RS26295	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
L6489_RS26305	COG1271	oxidase subunit
L6489_RS26310	COG1294	oxidase, subunit
L6489_RS26315	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6489_RS26350	COG1620	l-lactate permease
L6489_RS26360	COG2389	metal-binding protein
L6489_RS26370	COG1368	sulfuric ester hydrolase activity
L6489_RS26380	COG0791	NLP P60 protein
L6489_RS26380	COG1388	LysM domain
L6489_RS26385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6489_RS26395	COG1215	transferase activity, transferring glycosyl groups
L6489_RS26405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6489_RS26410	COG1388	LysM domain
L6489_RS26410	COG3584	3D domain protein
L6489_RS26420	COG4715	Zinc finger, swim domain protein
L6489_RS26425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6489_RS26470	COG0577	efflux transmembrane transporter activity
L6489_RS26475	COG1136	(ABC) transporter
L6489_RS26510	COG5002	protein histidine kinase activity
L6489_RS26510	COG3850	Histidine kinase
L6489_RS26515	COG0745	RESPONSE REGULATOR receiver
L6489_RS26520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6489_RS26540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L6489_RS26550	COG0438	transferase activity, transferring glycosyl groups
L6489_RS26570	COG0438	transferase activity, transferring glycosyl groups
L6489_RS26575	COG0438	transferase activity, transferring glycosyl groups
L6489_RS26580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L6489_RS26585	COG0151	Belongs to the GarS family
L6489_RS26595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L6489_RS26600	COG1086	Polysaccharide biosynthesis protein
L6489_RS26605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L6489_RS26610	COG4464	protein tyrosine phosphatase activity
L6489_RS26615	COG0489	protein tyrosine kinase activity
L6489_RS26620	COG3944	biosynthesis protein
L6489_RS26625	COG0489	protein tyrosine kinase activity
L6489_RS26640	COG1609	Transcriptional regulator
L6489_RS26650	COG0739	heme binding
L6489_RS26665	COG3279	Response regulator of the LytR AlgR family
L6489_RS26670	COG2385	sporulation resulting in formation of a cellular spore
L6489_RS26685	COG4836	Membrane
L6489_RS26690	COG1007	ATP synthesis coupled electron transport
L6489_RS26700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6489_RS26710	COG0839	Belongs to the complex I subunit 6 family
L6489_RS26730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6489_RS26745	COG3300	MHYT domain
L6489_RS26745	COG5001	Diguanylate cyclase
L6489_RS26795	COG0356	it plays a direct role in the translocation of protons across the membrane
L6489_RS26830	COG0698	ribose 5-phosphate isomerase
L6489_RS26840	COG2190	(PTS) system
L6489_RS26845	COG2259	Doxx family
L6489_RS26850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L6489_RS26870	COG0009	L-threonylcarbamoyladenylate synthase
L6489_RS26885	COG2890	protein-(glutamine-N5) methyltransferase activity
L6489_RS26905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L6489_RS26910	COG1494	fructose-1,6-bisphosphatase
L6489_RS26930	COG4821	SIS domain
L6489_RS26950	COG1960	acyl-CoA dehydrogenase activity
L6489_RS26955	COG1960	acyl-CoA dehydrogenase activity
L6489_RS26960	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6489_RS26965	COG0183	Belongs to the thiolase family
L6489_RS26970	COG0247	lactate metabolic process
L6489_RS26970	COG2181	nitrate reductase activity
L6489_RS26975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6489_RS26985	COG5001	Diguanylate cyclase
L6489_RS26985	COG3300	MHYT domain
L6489_RS27005	COG2197	response regulator
L6489_RS27010	COG4585	Histidine kinase
L6489_RS27015	COG0842	Transport permease protein
L6489_RS27020	COG1131	(ABC) transporter
L6489_RS27025	COG0024	Methionine aminopeptidase
L6489_RS27030	COG2234	aminopeptidase activity
L6489_RS27050	COG1595	DNA-templated transcription, initiation
L6489_RS27060	COG4506	Protein conserved in bacteria
L6489_RS27065	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6489_RS27080	COG0010	Belongs to the arginase family
L6489_RS27090	COG2814	Major facilitator Superfamily
L6489_RS27095	COG0789	Transcriptional regulator
L6489_RS27100	COG0584	glycerophosphoryl diester phosphodiesterase
L6489_RS27105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6489_RS27115	COG1994	Peptidase M50
L6489_RS27125	COG1078	dGTPase activity
L6489_RS27130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6489_RS27135	COG1120	ATPase activity
L6489_RS27140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6489_RS27145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6489_RS27165	COG0095	Lipoate-protein ligase
L6489_RS27170	COG0280	phosphate acetyltransferase
L6489_RS27185	COG3773	Cell wall hydrolase
L6489_RS27195	COG2363	Small membrane protein
L6489_RS27205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6489_RS27210	COG2233	PERMEase
L6489_RS27215	COG0561	phosphatase activity
L6489_RS27220	COG2814	Major facilitator Superfamily
L6489_RS27230	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6489_RS27235	COG1131	(ABC) transporter
L6489_RS27240	COG2755	lipolytic protein G-D-S-L family
L6489_RS27245	COG1609	Transcriptional regulator
L6489_RS27255	COG0460	homoserine dehydrogenase
L6489_RS27265	COG2873	o-acetylhomoserine
L6489_RS27270	COG1011	Hydrolase
L6489_RS27275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6489_RS27285	COG2197	response regulator
L6489_RS27290	COG4585	Histidine kinase
L6489_RS27290	COG2203	Gaf domain
L6489_RS27295	COG0351	phosphomethylpyrimidine kinase
L6489_RS27300	COG3706	GGDEF domain
L6489_RS27305	COG2879	small protein
L6489_RS27310	COG1966	Carbon starvation protein
L6489_RS27315	COG3279	Response regulator of the LytR AlgR family
L6489_RS27320	COG0477	Major facilitator Superfamily
L6489_RS27345	COG0840	transmembrane signaling receptor activity
L6489_RS27355	COG1607	acyl-coa hydrolase
L6489_RS27360	COG1216	Glycosyl transferase, family 2
L6489_RS27370	COG0488	(ABC) transporter
L6489_RS27390	COG0463	Glycosyl transferase, family 2
L6489_RS27395	COG1309	transcriptional regulator
L6489_RS27400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6489_RS27405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6489_RS27405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6489_RS27410	COG0628	permease
L6489_RS27425	COG3279	Response regulator of the LytR AlgR family
L6489_RS27430	COG3275	phosphorelay sensor kinase activity
L6489_RS27435	COG2814	Major facilitator Superfamily
L6489_RS27440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6489_RS27445	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
L6489_RS27450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6489_RS27500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6489_RS27505	COG1272	protein, Hemolysin III
L6489_RS27535	COG1164	Oligoendopeptidase f
L6489_RS27545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6489_RS27575	COG4974	Belongs to the 'phage' integrase family
L6489_RS27635	COG1196	nuclear chromosome segregation
L6489_RS27655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6489_RS27660	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L6489_RS27665	COG4853	Protein conserved in bacteria
L6489_RS27670	COG4863	YycH protein
L6489_RS27675	COG5002	protein histidine kinase activity
L6489_RS27680	COG0745	RESPONSE REGULATOR receiver
L6489_RS27710	COG0305	Participates in initiation and elongation during chromosome replication
L6489_RS27720	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
L6489_RS27725	COG4241	membrane
L6489_RS27735	COG0629	single-stranded DNA binding
L6489_RS27745	COG0012	GTP binding
L6489_RS27750	COG4481	Protein conserved in bacteria
L6489_RS27755	COG0668	transmembrane transport
L6489_RS27765	COG1475	DNA binding
L6489_RS27770	COG1192	Involved in chromosome partitioning
L6489_RS27795	COG1847	R3H domain protein
L6489_RS27800	COG0706	membrane insertase activity
L6489_RS27810	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L6489_RS27835	COG3344	reverse transcriptase
L6489_RS27855	COG3344	reverse transcriptase
L6489_RS27975	COG0457	Tetratricopeptide repeat
L6489_RS27990	COG4974	Belongs to the 'phage' integrase family
L6489_RS28025	COG0745	RESPONSE REGULATOR receiver
L6489_RS28030	COG4990	cell redox homeostasis
L6489_RS28035	COG1335	isochorismatase
L6489_RS28070	COG2918	glutathione biosynthetic process
L6489_RS28070	COG1181	Belongs to the D-alanine--D-alanine ligase family
L6489_RS28080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L6489_RS28090	COG1733	regulation of RNA biosynthetic process
L6489_RS28110	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6489_RS28125	COG3708	Transcriptional regulator
L6489_RS28125	COG2207	Transcriptional regulator
L6489_RS28195	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L6489_RS28230	COG2002	toxin-antitoxin pair type II binding
L6489_RS28270	COG0776	regulation of translation
L6489_RS28300	COG2311	Membrane
L6489_RS28330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6489_RS28335	COG1621	beta-fructofuranosidase activity
L6489_RS28340	COG1263	PTS System
L6489_RS28340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6489_RS28345	COG1609	Transcriptional regulator
L6489_RS28890	COG0640	Transcriptional regulator
L6489_RS28935	COG0791	NLP P60 protein
L6489_RS28935	COG1388	LysM domain
L6489_RS28935	COG3103	Sh3 type 3 domain protein
L6489_RS28970	COG3397	chitin binding
L6489_RS29035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L6489_RS29050	COG2003	Belongs to the UPF0758 family
L6489_RS29080	COG0582	viral genome integration into host DNA
L6489_RS29085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6489_RS29120	COG1396	sequence-specific DNA binding