locus-tag	class	description
C2I25_RS00015	COG5506	Protein of unknown function (DUF1694)
C2I25_RS00020	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_RS00025	COG1253	flavin adenine dinucleotide binding
C2I25_RS00060	COG1732	Glycine betaine
C2I25_RS00105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2I25_RS00130	COG1064	alcohol dehydrogenase
C2I25_RS00135	COG0384	phenazine biosynthesis protein PhzF
C2I25_RS00140	COG1737	Transcriptional regulator
C2I25_RS00145	COG2197	response regulator
C2I25_RS00150	COG2203	Gaf domain
C2I25_RS00150	COG4585	Histidine kinase
C2I25_RS00155	COG0668	transmembrane transport
C2I25_RS00160	COG1335	isochorismatase
C2I25_RS00180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I25_RS00185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_RS00190	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I25_RS00205	COG0367	asparagine synthase
C2I25_RS00210	COG0071	Belongs to the small heat shock protein (HSP20) family
C2I25_RS00215	COG1999	signal sequence binding
C2I25_RS00225	COG1307	EDD domain protein, DegV family
C2I25_RS00240	COG0805	protein transport
C2I25_RS00250	COG1272	protein, Hemolysin III
C2I25_RS00255	COG0204	Acyl-transferase
C2I25_RS00265	COG0768	penicillin binding
C2I25_RS00280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I25_RS00295	COG0546	phosphoglycolate phosphatase activity
C2I25_RS00305	COG4473	ABC transporter
C2I25_RS00310	COG1131	(ABC) transporter
C2I25_RS00320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2I25_RS00325	COG3655	Transcriptional regulator
C2I25_RS00335	COG0456	acetyltransferase
C2I25_RS00345	COG1794	racemase activity, acting on amino acids and derivatives
C2I25_RS00355	COG2610	gluconate transmembrane transporter activity
C2I25_RS00380	COG0733	neurotransmitter:sodium symporter activity
C2I25_RS00405	COG5444	nuclease activity
C2I25_RS00435	COG1674	ftsk spoiiie
C2I25_RS00455	COG0017	Asparaginyl-tRNA synthetase
C2I25_RS00500	COG0018	arginyl-trna synthetase
C2I25_RS00505	COG2136	Putative SAM-dependent methyltransferase
C2I25_RS00505	COG2521	methyltransferase
C2I25_RS00520	COG1413	lyase activity
C2I25_RS00530	COG0629	single-stranded DNA binding
C2I25_RS00545	COG0488	(ABC) transporter
C2I25_RS00550	COG1418	mRNA catabolic process
C2I25_RS00595	COG0457	Tetratricopeptide repeat
C2I25_RS00680	COG3547	Transposase (IS116 IS110 IS902 family)
C2I25_RS00725	COG4653	Phage capsid family
C2I25_RS00730	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2I25_RS00745	COG1783	phage Terminase large subunit
C2I25_RS00750	COG5484	DNA packaging
C2I25_RS00760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2I25_RS00800	COG0662	Cupin 2, conserved barrel domain protein
C2I25_RS00805	COG0582	viral genome integration into host DNA
C2I25_RS00880	COG1396	sequence-specific DNA binding
C2I25_RS00885	COG0515	serine threonine protein kinase
C2I25_RS00885	COG2815	serine threonine protein kinase
C2I25_RS00900	COG2856	Zn peptidase
C2I25_RS00925	COG2359	stage V sporulation protein S
C2I25_RS00960	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C2I25_RS00965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2I25_RS00970	COG2146	nitrite reductase [NAD(P)H] activity
C2I25_RS00975	COG1587	Uroporphyrinogen-III synthase
C2I25_RS00975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2I25_RS00985	COG1648	precorrin-2 dehydrogenase activity
C2I25_RS01005	COG2223	nitrite transmembrane transporter activity
C2I25_RS01015	COG0314	molybdopterin synthase activity
C2I25_RS01020	COG0303	'Molybdopterin
C2I25_RS01025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I25_RS01030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2I25_RS01035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I25_RS01040	COG2181	nitrate reductase activity
C2I25_RS01045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2I25_RS01050	COG1140	nitrate reductase beta subunit
C2I25_RS01055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2I25_RS01060	COG0714	Associated with various cellular activities
C2I25_RS01065	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C2I25_RS01070	COG1305	Transglutaminase-like
C2I25_RS01075	COG0386	Belongs to the glutathione peroxidase family
C2I25_RS01085	COG0426	domain, Protein
C2I25_RS01085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2I25_RS01100	COG1595	DNA-templated transcription, initiation
C2I25_RS01105	COG0604	alcohol dehydrogenase
C2I25_RS01115	COG0346	lactoylglutathione lyase activity
C2I25_RS01120	COG1082	Xylose isomerase domain protein TIM barrel
C2I25_RS01140	COG2226	methyltransferase
C2I25_RS01165	COG3874	Sporulation protein YtfJ
C2I25_RS01190	COG0456	acetyltransferase
C2I25_RS01220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_RS01225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_RS01230	COG1819	glycosyl
C2I25_RS01245	COG4106	trans-aconitate 2-methyltransferase activity
C2I25_RS01250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2I25_RS01260	COG2814	Major facilitator Superfamily
C2I25_RS01265	COG1846	Transcriptional regulator
C2I25_RS01270	COG0561	phosphatase activity
C2I25_RS01280	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I25_RS01295	COG2211	Major facilitator Superfamily
C2I25_RS01310	COG1876	peptidase activity
C2I25_RS01325	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I25_RS01345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2I25_RS01350	COG1114	Component of the transport system for branched-chain amino acids
C2I25_RS01375	COG1253	flavin adenine dinucleotide binding
C2I25_RS01380	COG2839	Protein conserved in bacteria
C2I25_RS01385	COG0702	epimerase
C2I25_RS01400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I25_RS01410	COG1607	acyl-coa hydrolase
C2I25_RS01415	COG3689	TIGRFAM TIGR03943 family protein
C2I25_RS01420	COG0701	Predicted permease
C2I25_RS01430	COG2244	polysaccharide biosynthetic process
C2I25_RS01435	COG0586	Pfam SNARE associated Golgi protein
C2I25_RS01440	COG1051	belongs to the nudix hydrolase family
C2I25_RS01445	COG5337	Spore coat protein CotH
C2I25_RS01470	COG4166	transmembrane transport
C2I25_RS01480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2I25_RS01490	COG0702	epimerase
C2I25_RS01495	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2I25_RS01500	COG0456	acetyltransferase
C2I25_RS01505	COG0523	cobalamin synthesis protein
C2I25_RS01515	COG4989	oxidoreductase activity
C2I25_RS01520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS01525	COG1231	oxidoreductase activity
C2I25_RS01535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I25_RS01550	COG0783	Belongs to the Dps family
C2I25_RS01555	COG3949	Membrane
C2I25_RS01575	COG0840	transmembrane signaling receptor activity
C2I25_RS01600	COG2814	Major facilitator Superfamily
C2I25_RS01605	COG0667	Aldo Keto reductase
C2I25_RS01610	COG0640	Transcriptional regulator
C2I25_RS01615	COG1404	Belongs to the peptidase S8 family
C2I25_RS01620	COG2002	toxin-antitoxin pair type II binding
C2I25_RS01625	COG0577	efflux transmembrane transporter activity
C2I25_RS01660	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2I25_RS01670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_RS01675	COG1279	arginine transmembrane transporter activity
C2I25_RS01680	COG2814	Major facilitator Superfamily
C2I25_RS01690	COG1082	Xylose isomerase domain protein TIM barrel
C2I25_RS01700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2I25_RS01720	COG1247	-acetyltransferase
C2I25_RS01725	COG1285	pathogenesis
C2I25_RS01740	COG5002	protein histidine kinase activity
C2I25_RS01745	COG0745	RESPONSE REGULATOR receiver
C2I25_RS01755	COG1316	TRANSCRIPTIONal
C2I25_RS01780	COG0460	homoserine dehydrogenase
C2I25_RS01810	COG4122	O-methyltransferase activity
C2I25_RS01815	COG0300	oxidoreductase activity
C2I25_RS01825	COG5002	protein histidine kinase activity
C2I25_RS01830	COG0745	RESPONSE REGULATOR receiver
C2I25_RS01835	COG1132	(ABC) transporter
C2I25_RS01845	COG1388	LysM domain
C2I25_RS01845	COG0791	NLP P60 protein
C2I25_RS01860	COG1686	Belongs to the peptidase S11 family
C2I25_RS01895	COG1216	Glycosyl transferase, family 2
C2I25_RS01905	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2I25_RS01910	COG4988	ABC transporter
C2I25_RS01915	COG1294	oxidase, subunit
C2I25_RS01920	COG1271	oxidase subunit
C2I25_RS01940	COG1942	4-Oxalocrotonate Tautomerase
C2I25_RS01950	COG0583	DNA-binding transcription factor activity
C2I25_RS01970	COG0411	ABC transporter
C2I25_RS01980	COG0523	cobalamin synthesis protein
C2I25_RS01990	COG1231	oxidoreductase activity
C2I25_RS02000	COG0628	permease
C2I25_RS02015	COG0778	Nitroreductase
C2I25_RS02020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2I25_RS02025	COG1959	2 iron, 2 sulfur cluster binding
C2I25_RS02030	COG0583	DNA-binding transcription factor activity
C2I25_RS02035	COG0697	spore germination
C2I25_RS02040	COG4549	nuclear export factor GLE1
C2I25_RS02045	COG2372	response to copper ion
C2I25_RS02045	COG1276	copper resistance
C2I25_RS02085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I25_RS02095	COG1834	amidinotransferase
C2I25_RS02115	COG1114	Component of the transport system for branched-chain amino acids
C2I25_RS02135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2I25_RS02150	COG2132	Multicopper oxidase
C2I25_RS02160	COG0006	proline dipeptidase activity
C2I25_RS02175	COG0583	DNA-binding transcription factor activity
C2I25_RS02195	COG4846	Membrane protein involved in cytochrome C biogenesis
C2I25_RS02200	COG0295	cytidine deaminase activity
C2I25_RS02205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2I25_RS02210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_RS02220	COG2390	Transcriptional regulator
C2I25_RS02225	COG1309	transcriptional regulator
C2I25_RS02230	COG1266	CAAX protease self-immunity
C2I25_RS02245	COG0456	acetyltransferase
C2I25_RS02260	COG2309	aminopeptidase activity
C2I25_RS02290	COG0531	amino acid
C2I25_RS02295	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2I25_RS02310	COG1914	H( )-stimulated, divalent metal cation uptake system
C2I25_RS02330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS02335	COG4166	transmembrane transport
C2I25_RS02355	COG0427	acetyl-CoA hydrolase
C2I25_RS02360	COG3279	Response regulator of the LytR AlgR family
C2I25_RS02365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2I25_RS02375	COG3384	dioxygenase
C2I25_RS02380	COG2814	Major facilitator Superfamily
C2I25_RS02400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2I25_RS02420	COG0028	Belongs to the TPP enzyme family
C2I25_RS02425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I25_RS02435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2I25_RS02465	COG2323	membrane
C2I25_RS02470	COG5566	PFAM Mor transcription activator
C2I25_RS02480	COG0733	neurotransmitter:sodium symporter activity
C2I25_RS02495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I25_RS02500	COG2223	nitrite transmembrane transporter activity
C2I25_RS02505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2I25_RS02515	COG0477	Major facilitator Superfamily
C2I25_RS02525	COG1695	Transcriptional regulator
C2I25_RS02595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2I25_RS02600	COG0784	Response regulator, receiver
C2I25_RS02605	COG4191	Histidine kinase
C2I25_RS02610	COG0281	malic enzyme
C2I25_RS02615	COG1027	Aspartate ammonia-lyase
C2I25_RS02625	COG0528	UMP kinase activity
C2I25_RS02630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I25_RS02645	COG1131	(ABC) transporter
C2I25_RS02685	COG2733	membrane
C2I25_RS02705	COG0457	Tetratricopeptide repeat
C2I25_RS02720	COG0785	Cytochrome C biogenesis protein
C2I25_RS02740	COG3340	Belongs to the peptidase S51 family
C2I25_RS02745	COG0534	Mate efflux family protein
C2I25_RS02775	COG0789	Transcriptional regulator
C2I25_RS02780	COG1757	Na H antiporter
C2I25_RS02795	COG0701	Predicted permease
C2I25_RS02805	COG0523	cobalamin synthesis protein
C2I25_RS02815	COG0697	spore germination
C2I25_RS02820	COG1802	Transcriptional regulator
C2I25_RS02850	COG0367	asparagine synthase
C2I25_RS02880	COG0406	alpha-ribazole phosphatase activity
C2I25_RS02925	COG3842	ATPase activity
C2I25_RS02930	COG0583	DNA-binding transcription factor activity
C2I25_RS02955	COG2329	Antibiotic biosynthesis monooxygenase
C2I25_RS02995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I25_RS03000	COG4786	Flagellar basal body rod
C2I25_RS03005	COG1419	protein localization to endoplasmic reticulum
C2I25_RS03010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2I25_RS03015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2I25_RS03025	COG1987	bacterial-type flagellum assembly
C2I25_RS03030	COG1338	Plays a role in the flagellum-specific transport system
C2I25_RS03040	COG1776	CheC inhibitor of MCP methylation
C2I25_RS03040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I25_RS03045	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I25_RS03055	COG0741	lytic transglycosylase activity
C2I25_RS03060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I25_RS03065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I25_RS03070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I25_RS03075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I25_RS03085	COG0835	chemotaxis
C2I25_RS03085	COG0784	Response regulator, receiver
C2I25_RS03120	COG1157	protein secretion by the type III secretion system
C2I25_RS03130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I25_RS03135	COG1766	The M ring may be actively involved in energy transduction
C2I25_RS03145	COG1558	bacterial-type flagellum-dependent cell motility
C2I25_RS03150	COG1815	bacterial-type flagellum-dependent cell motility
C2I25_RS03165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2I25_RS03170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I25_RS03175	COG1256	bacterial-type flagellum assembly
C2I25_RS03195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2I25_RS03210	COG1776	CheC inhibitor of MCP methylation
C2I25_RS03210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I25_RS03215	COG0643	Histidine kinase
C2I25_RS03215	COG2198	Histidine kinase
C2I25_RS03220	COG2201	protein-glutamate methylesterase activity
C2I25_RS03225	COG1360	Flagellar Motor Protein
C2I25_RS03230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2I25_RS03240	COG1923	regulation of RNA biosynthetic process
C2I25_RS03300	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2I25_RS03305	COG2323	membrane
C2I25_RS03315	COG4978	Transcriptional regulator
C2I25_RS03315	COG0789	Transcriptional regulator
C2I25_RS03320	COG0475	glutathione-regulated potassium exporter activity
C2I25_RS03330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2I25_RS03335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I25_RS03355	COG1280	lysine exporter protein (LysE YggA)
C2I25_RS03360	COG3403	YqcI/YcgG family
C2I25_RS03395	COG0328	RNA-DNA hybrid ribonuclease activity
C2I25_RS03415	COG0454	-acetyltransferase
C2I25_RS03430	COG0438	transferase activity, transferring glycosyl groups
C2I25_RS03435	COG1215	transferase activity, transferring glycosyl groups
C2I25_RS03450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2I25_RS03460	COG3944	biosynthesis protein
C2I25_RS03475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2I25_RS03525	COG0456	acetyltransferase
C2I25_RS03535	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2I25_RS03545	COG2311	Membrane
C2I25_RS03550	COG2233	PERMEase
C2I25_RS03560	COG0024	Methionine aminopeptidase
C2I25_RS03570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2I25_RS03575	COG1199	ATP-dependent helicase activity
C2I25_RS03585	COG0116	Belongs to the methyltransferase superfamily
C2I25_RS03645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I25_RS03645	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2I25_RS03655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2I25_RS03660	COG3935	DnaD domain protein
C2I25_RS03680	COG1199	ATP-dependent helicase activity
C2I25_RS03680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2I25_RS03720	COG0438	transferase activity, transferring glycosyl groups
C2I25_RS03740	COG1694	Mazg nucleotide pyrophosphohydrolase
C2I25_RS03750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_RS03760	COG2738	Putative neutral zinc metallopeptidase
C2I25_RS03775	COG4347	Protein of unknown function (DUF1405)
C2I25_RS03780	COG2010	Cytochrome c
C2I25_RS03780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2I25_RS03785	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2I25_RS03805	COG0457	Tetratricopeptide repeat
C2I25_RS03830	COG0142	geranyltranstransferase activity
C2I25_RS03840	COG0142	geranyltranstransferase activity
C2I25_RS03855	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2I25_RS03925	COG0252	asparaginase activity
C2I25_RS03930	COG0492	ferredoxin-NADP+ reductase activity
C2I25_RS03950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2I25_RS03965	COG1408	metallophosphoesterase
C2I25_RS03975	COG1266	CAAX protease self-immunity
C2I25_RS03980	COG0514	ATP-dependent DNA helicase (RecQ)
C2I25_RS03990	COG1141	Ferredoxin
C2I25_RS03995	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2I25_RS04010	COG2096	Adenosyltransferase
C2I25_RS04015	COG5002	protein histidine kinase activity
C2I25_RS04020	COG0745	RESPONSE REGULATOR receiver
C2I25_RS04025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2I25_RS04030	COG1333	cytochrome c biogenesis protein
C2I25_RS04040	COG1187	pseudouridine synthase activity
C2I25_RS04045	COG0700	Nucleoside recognition
C2I25_RS04050	COG2715	membrane protein required for spore maturation
C2I25_RS04055	COG1686	Belongs to the peptidase S11 family
C2I25_RS04060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2I25_RS04075	COG0392	lysyltransferase activity
C2I25_RS04075	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2I25_RS04095	COG5002	protein histidine kinase activity
C2I25_RS04100	COG0582	viral genome integration into host DNA
C2I25_RS04110	COG1801	Protein of unknown function DUF72
C2I25_RS04115	COG3852	Histidine kinase
C2I25_RS04130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I25_RS04135	COG1392	Phosphate transport regulator
C2I25_RS04140	COG0306	phosphate transporter
C2I25_RS04145	COG0730	response to heat
C2I25_RS04200	COG1114	Component of the transport system for branched-chain amino acids
C2I25_RS04210	COG2197	response regulator
C2I25_RS04215	COG4585	Histidine kinase
C2I25_RS04220	COG4758	membrane
C2I25_RS04235	COG1757	Na H antiporter
C2I25_RS04255	COG0733	neurotransmitter:sodium symporter activity
C2I25_RS04265	COG1648	precorrin-2 dehydrogenase activity
C2I25_RS04285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2I25_RS04290	COG0529	Catalyzes the synthesis of activated sulfate
C2I25_RS04310	COG0019	diaminopimelate decarboxylase activity
C2I25_RS04320	COG1368	sulfuric ester hydrolase activity
C2I25_RS04325	COG1183	phosphatidylcholine synthase activity
C2I25_RS04340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2I25_RS04415	COG0440	acetolactate synthase activity
C2I25_RS04420	COG0028	Belongs to the TPP enzyme family
C2I25_RS04425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I25_RS04455	COG3874	Sporulation protein YtfJ
C2I25_RS04460	COG4709	membrane
C2I25_RS04465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2I25_RS04470	COG1301	dicarboxylic acid transport
C2I25_RS04480	COG1846	Transcriptional regulator
C2I25_RS04525	COG3173	Aminoglycoside phosphotransferase
C2I25_RS04540	COG0716	FMN binding
C2I25_RS04565	COG1696	Membrane protein involved in D-alanine export
C2I25_RS04575	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2I25_RS04580	COG2070	2-Nitropropane dioxygenase
C2I25_RS04585	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2I25_RS04595	COG1335	isochorismatase
C2I25_RS04605	COG1522	sequence-specific DNA binding
C2I25_RS04615	COG1266	CAAX protease self-immunity
C2I25_RS04620	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2I25_RS04625	COG1131	(ABC) transporter
C2I25_RS04635	COG1131	(ABC) transporter
C2I25_RS04640	COG1725	Transcriptional regulator
C2I25_RS04645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2I25_RS04650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2I25_RS04655	COG1780	Probably involved in ribonucleotide reductase function
C2I25_RS04690	COG4873	Protein conserved in bacteria
C2I25_RS04705	COG0720	synthase
C2I25_RS04715	COG5002	protein histidine kinase activity
C2I25_RS04725	COG2318	DinB family
C2I25_RS04735	COG1846	Transcriptional regulator
C2I25_RS04740	COG3852	Histidine kinase
C2I25_RS04750	COG2861	carbohydrate metabolic process
C2I25_RS04760	COG0235	Class ii aldolase
C2I25_RS04775	COG1349	DNA-binding transcription factor activity
C2I25_RS04800	COG3842	ATPase activity
C2I25_RS04805	COG1840	ABC-type Fe3 transport system, periplasmic component
C2I25_RS04825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2I25_RS04835	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2I25_RS04840	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS04860	COG2030	dehydratase
C2I25_RS04870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2I25_RS04875	COG0861	Integral membrane protein TerC family
C2I25_RS04880	COG2116	formate transmembrane transporter activity
C2I25_RS04890	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2I25_RS04910	COG2186	Transcriptional regulator
C2I25_RS04915	COG5002	protein histidine kinase activity
C2I25_RS04920	COG0745	RESPONSE REGULATOR receiver
C2I25_RS04930	COG3835	regulator
C2I25_RS04935	COG0277	FAD linked oxidase domain protein
C2I25_RS04940	COG0247	lactate metabolic process
C2I25_RS04945	COG2340	Cysteine-rich secretory protein family
C2I25_RS04955	COG0564	pseudouridine synthase activity
C2I25_RS04965	COG2409	Drug exporters of the RND superfamily
C2I25_RS04980	COG1177	transmembrane transport
C2I25_RS04985	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2I25_RS04995	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_RS05030	COG0681	Belongs to the peptidase S26 family
C2I25_RS05035	COG1686	Belongs to the peptidase S11 family
C2I25_RS05065	COG1668	transmembrane transport
C2I25_RS05070	COG4152	abc transporter atp-binding protein
C2I25_RS05110	COG1476	TRANSCRIPTIONal
C2I25_RS05120	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I25_RS05180	COG5634	Uncharacterized conserved protein (DUF2278)
C2I25_RS05185	COG1620	l-lactate permease
C2I25_RS05220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2I25_RS05220	COG0512	Glutamine amidotransferase of anthranilate synthase
C2I25_RS05235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I25_RS05255	COG2382	esterase
C2I25_RS05265	COG2153	protein acetylation
C2I25_RS05310	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2I25_RS05325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2I25_RS05345	COG0463	Glycosyl transferase, family 2
C2I25_RS05345	COG0457	Tetratricopeptide repeat
C2I25_RS05365	COG1216	Glycosyl transferase, family 2
C2I25_RS05370	COG0772	Belongs to the SEDS family
C2I25_RS05385	COG0564	pseudouridine synthase activity
C2I25_RS05395	COG2357	RelA SpoT domain protein
C2I25_RS05405	COG4116	CYTH
C2I25_RS05410	COG2346	COG2346, Truncated hemoglobins
C2I25_RS05425	COG1164	Oligoendopeptidase f
C2I25_RS05435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I25_RS05445	COG0861	Integral membrane protein TerC family
C2I25_RS05465	COG4166	transmembrane transport
C2I25_RS05470	COG0534	Mate efflux family protein
C2I25_RS05475	COG4608	Belongs to the ABC transporter superfamily
C2I25_RS05480	COG0444	Belongs to the ABC transporter superfamily
C2I25_RS05485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I25_RS05490	COG0601	transmembrane transport
C2I25_RS05495	COG4166	transmembrane transport
C2I25_RS05510	COG0180	Tryptophanyl-tRNA synthetase
C2I25_RS05520	COG5504	Zn-dependent protease
C2I25_RS05525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2I25_RS05530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I25_RS05545	COG2267	carboxylic ester hydrolase activity
C2I25_RS05570	COG0561	phosphatase activity
C2I25_RS05585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_RS05600	COG2996	Protein conserved in bacteria
C2I25_RS05625	COG0004	ammonium transporteR
C2I25_RS05630	COG0753	catalase activity
C2I25_RS05640	COG0367	asparagine synthase
C2I25_RS05665	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2I25_RS05705	COG0202	RNA polymerase activity
C2I25_RS05725	COG0398	Pfam SNARE associated Golgi protein
C2I25_RS05760	COG2224	Isocitrate lyase
C2I25_RS05765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2I25_RS05775	COG3693	PFAM glycoside hydrolase, family 10
C2I25_RS05785	COG0840	transmembrane signaling receptor activity
C2I25_RS05790	COG0501	Belongs to the peptidase M48B family
C2I25_RS05810	COG0745	RESPONSE REGULATOR receiver
C2I25_RS05815	COG2205	protein histidine kinase activity
C2I25_RS05825	COG2207	Transcriptional regulator
C2I25_RS05825	COG3708	Transcriptional regulator
C2I25_RS05830	COG1595	DNA-templated transcription, initiation
C2I25_RS05840	COG0477	Major facilitator Superfamily
C2I25_RS05850	COG1078	dGTPase activity
C2I25_RS05860	COG1408	metallophosphoesterase
C2I25_RS05930	COG4208	sulfate ABC transporter
C2I25_RS05940	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2I25_RS05950	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_RS05960	COG0095	Lipoate-protein ligase
C2I25_RS05965	COG1234	tRNA 3'-trailer cleavage
C2I25_RS05975	COG1609	Transcriptional regulator
C2I25_RS06000	COG1511	domain protein
C2I25_RS06005	COG1309	transcriptional regulator
C2I25_RS06040	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C2I25_RS06055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I25_RS06060	COG2329	Antibiotic biosynthesis monooxygenase
C2I25_RS06065	COG3428	Bacterial PH domain
C2I25_RS06070	COG3402	PFAM membrane-flanked domain
C2I25_RS06075	COG0697	spore germination
C2I25_RS06115	COG3428	Bacterial PH domain
C2I25_RS06120	COG3402	PFAM membrane-flanked domain
C2I25_RS06130	COG1309	transcriptional regulator
C2I25_RS06165	COG4473	ABC transporter
C2I25_RS06170	COG1131	(ABC) transporter
C2I25_RS06180	COG0537	adenosine 5'-monophosphoramidase activity
C2I25_RS06185	COG4980	gas vesicle protein
C2I25_RS06220	COG3973	AAA domain
C2I25_RS06260	COG1695	Transcriptional regulator
C2I25_RS06265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2I25_RS06275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2I25_RS06280	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2I25_RS06290	COG2140	Oxalate decarboxylase
C2I25_RS06305	COG2267	carboxylic ester hydrolase activity
C2I25_RS06315	COG0457	Tetratricopeptide repeat
C2I25_RS06320	COG0346	lactoylglutathione lyase activity
C2I25_RS06325	COG0346	lactoylglutathione lyase activity
C2I25_RS06330	COG1280	lysine exporter protein (LysE YggA)
C2I25_RS06345	COG4717	serine-type aminopeptidase activity
C2I25_RS06350	COG0420	3'-5' exonuclease activity
C2I25_RS06370	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C2I25_RS06415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2I25_RS06420	COG2208	phosphoserine phosphatase activity
C2I25_RS06430	COG1191	sigma factor activity
C2I25_RS06455	COG3237	CsbD-like
C2I25_RS06485	COG0596	Alpha beta hydrolase
C2I25_RS06495	COG2373	Large extracellular alpha-helical protein
C2I25_RS06535	COG2376	Dihydroxyacetone kinase
C2I25_RS06550	COG2376	Dihydroxyacetone kinase
C2I25_RS06565	COG0640	Transcriptional regulator
C2I25_RS06570	COG2814	Major facilitator Superfamily
C2I25_RS06585	COG1183	phosphatidylcholine synthase activity
C2I25_RS06645	COG1073	alpha beta
C2I25_RS06670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS06685	COG0477	Major facilitator Superfamily
C2I25_RS06720	COG0305	Participates in initiation and elongation during chromosome replication
C2I25_RS06735	COG4978	Transcriptional regulator
C2I25_RS06735	COG0789	Transcriptional regulator
C2I25_RS06770	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C2I25_RS06800	COG3181	Tripartite tricarboxylate transporter family receptor
C2I25_RS06805	COG4565	transcriptional regulatory protein
C2I25_RS06810	COG3290	protein histidine kinase activity
C2I25_RS06815	COG0477	Major facilitator Superfamily
C2I25_RS06840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS06850	COG4608	Belongs to the ABC transporter superfamily
C2I25_RS06855	COG0444	Belongs to the ABC transporter superfamily
C2I25_RS06860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I25_RS06865	COG0601	transmembrane transport
C2I25_RS06905	COG1363	Peptidase, m42
C2I25_RS06925	COG1024	Enoyl-CoA hydratase
C2I25_RS06945	COG2244	polysaccharide biosynthetic process
C2I25_RS06950	COG0659	secondary active sulfate transmembrane transporter activity
C2I25_RS06965	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_RS06970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2I25_RS06975	COG3409	Peptidoglycan-binding domain 1 protein
C2I25_RS06975	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2I25_RS06985	COG0561	phosphatase activity
C2I25_RS07000	COG3527	Alpha-acetolactate decarboxylase
C2I25_RS07005	COG0028	Belongs to the TPP enzyme family
C2I25_RS07040	COG0189	ligase activity
C2I25_RS07055	COG1126	abc transporter atp-binding protein
C2I25_RS07060	COG0765	amino acid transport
C2I25_RS07065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I25_RS07075	COG1132	(ABC) transporter
C2I25_RS07080	COG1132	(ABC) transporter
C2I25_RS07100	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_RS07115	COG0531	amino acid
C2I25_RS07125	COG0693	protein deglycase activity
C2I25_RS07145	COG1733	regulation of RNA biosynthetic process
C2I25_RS07150	COG2814	Major facilitator Superfamily
C2I25_RS07155	COG1309	transcriptional regulator
C2I25_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS07180	COG0165	Argininosuccinate lyase
C2I25_RS07180	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2I25_RS07185	COG1522	sequence-specific DNA binding
C2I25_RS07205	COG2259	Doxx family
C2I25_RS07215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_RS07215	COG1263	PTS System
C2I25_RS07225	COG1737	Transcriptional regulator
C2I25_RS07235	COG0475	glutathione-regulated potassium exporter activity
C2I25_RS07240	COG0531	amino acid
C2I25_RS07275	COG0586	Pfam SNARE associated Golgi protein
C2I25_RS07310	COG3546	catalase activity
C2I25_RS07315	COG1114	Component of the transport system for branched-chain amino acids
C2I25_RS07330	COG5522	Integral membrane protein (intg_mem_TP0381)
C2I25_RS07340	COG1136	(ABC) transporter
C2I25_RS07345	COG0577	efflux transmembrane transporter activity
C2I25_RS07350	COG1388	LysM domain
C2I25_RS07350	COG3584	3D domain protein
C2I25_RS07375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I25_RS07380	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I25_RS07385	COG3711	transcriptional antiterminator
C2I25_RS07385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I25_RS07405	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2I25_RS07410	COG0604	alcohol dehydrogenase
C2I25_RS07415	COG1316	TRANSCRIPTIONal
C2I25_RS07425	COG0730	response to heat
C2I25_RS07430	COG2210	Belongs to the sulfur carrier protein TusA family
C2I25_RS07445	COG0425	Belongs to the sulfur carrier protein TusA family
C2I25_RS07450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I25_RS07450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS07455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I25_RS07455	COG0425	Belongs to the sulfur carrier protein TusA family
C2I25_RS07460	COG1937	Protein conserved in bacteria
C2I25_RS07465	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2I25_RS07485	COG1414	Transcriptional regulator
C2I25_RS07495	COG2719	SpoVR family
C2I25_RS07500	COG0778	Nitroreductase
C2I25_RS07550	COG1609	Transcriptional regulator
C2I25_RS07555	COG1263	PTS System
C2I25_RS07555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_RS07560	COG1621	beta-fructofuranosidase activity
C2I25_RS07565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I25_RS07580	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS07585	COG2252	PERMEase
C2I25_RS07590	COG1879	ABC-type sugar transport system periplasmic component
C2I25_RS07595	COG1129	ABC transporter
C2I25_RS07600	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2I25_RS07615	COG1136	(ABC) transporter
C2I25_RS07640	COG1846	Transcriptional regulator
C2I25_RS07645	COG2814	Major facilitator Superfamily
C2I25_RS07650	COG2205	protein histidine kinase activity
C2I25_RS07695	COG0351	phosphomethylpyrimidine kinase
C2I25_RS07700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I25_RS07710	COG2104	thiamine diphosphate biosynthetic process
C2I25_RS07715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I25_RS07720	COG0352	thiamine-phosphate diphosphorylase activity
C2I25_RS07725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2I25_RS07730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I25_RS07735	COG1116	anion transmembrane transporter activity
C2I25_RS07740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2I25_RS07765	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C2I25_RS07890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2I25_RS07900	COG0581	inorganic phosphate transmembrane transporter activity
C2I25_RS07905	COG0573	inorganic phosphate transmembrane transporter activity
C2I25_RS07910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2I25_RS07915	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2I25_RS07915	COG1918	ferrous iron import across plasma membrane
C2I25_RS07920	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2I25_RS07925	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2I25_RS07940	COG0531	amino acid
C2I25_RS07945	COG0697	spore germination
C2I25_RS07950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I25_RS07965	COG4990	cell redox homeostasis
C2I25_RS07970	COG0833	amino acid
C2I25_RS07980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2I25_RS07995	COG0475	glutathione-regulated potassium exporter activity
C2I25_RS07995	COG0569	domain protein
C2I25_RS08005	COG2153	protein acetylation
C2I25_RS08020	COG2252	PERMEase
C2I25_RS08025	COG1113	amino acid transport
C2I25_RS08040	COG1114	Component of the transport system for branched-chain amino acids
C2I25_RS08045	COG3104	oligopeptide transport
C2I25_RS08065	COG1476	TRANSCRIPTIONal
C2I25_RS08070	COG3584	3D domain protein
C2I25_RS08070	COG1388	LysM domain
C2I25_RS08075	COG0840	transmembrane signaling receptor activity
C2I25_RS08125	COG1063	alcohol dehydrogenase
C2I25_RS08155	COG1879	ABC-type sugar transport system periplasmic component
C2I25_RS08160	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2I25_RS08175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I25_RS08180	COG1609	Transcriptional regulator
C2I25_RS08185	COG0477	Major facilitator Superfamily
C2I25_RS08190	COG1846	Transcriptional regulator
C2I25_RS08195	COG2271	Major facilitator Superfamily
C2I25_RS08205	COG4608	Belongs to the ABC transporter superfamily
C2I25_RS08210	COG0601	transmembrane transport
C2I25_RS08235	COG0659	secondary active sulfate transmembrane transporter activity
C2I25_RS08250	COG5002	protein histidine kinase activity
C2I25_RS08260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2I25_RS08265	COG2378	regulation of single-species biofilm formation
C2I25_RS08280	COG0833	amino acid
C2I25_RS08285	COG0765	amino acid transport
C2I25_RS08290	COG0765	amino acid transport
C2I25_RS08295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I25_RS08300	COG1126	abc transporter atp-binding protein
C2I25_RS08305	COG1115	amino acid carrier protein
C2I25_RS08310	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2I25_RS08315	COG0697	spore germination
C2I25_RS08330	COG0366	Alpha amylase catalytic
C2I25_RS08335	COG1263	PTS System
C2I25_RS08335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_RS08340	COG2188	Transcriptional regulator
C2I25_RS08345	COG0531	amino acid
C2I25_RS08365	COG0714	Associated with various cellular activities
C2I25_RS08370	COG4548	von Willebrand factor, type A
C2I25_RS08380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2I25_RS08385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I25_RS08390	COG0156	8-amino-7-oxononanoate synthase activity
C2I25_RS08405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_RS08410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_RS08415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_RS08420	COG3104	oligopeptide transport
C2I25_RS08435	COG1620	l-lactate permease
C2I25_RS08440	COG1027	Aspartate ammonia-lyase
C2I25_RS08445	COG1253	flavin adenine dinucleotide binding
C2I25_RS08450	COG0346	lactoylglutathione lyase activity
C2I25_RS08455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_RS08460	COG1316	TRANSCRIPTIONal
C2I25_RS08465	COG2720	vancomycin resistance protein
C2I25_RS08485	COG3227	Zinc metalloprotease (Elastase)
C2I25_RS08495	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2I25_RS08500	COG2217	Heavy metal translocating P-type atpase
C2I25_RS08505	COG0640	Transcriptional regulator
C2I25_RS08520	COG0531	amino acid
C2I25_RS08535	COG2427	Protein of unknown function (DUF1641)
C2I25_RS08540	COG3383	formate dehydrogenase (NAD+) activity
C2I25_RS08545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2I25_RS08550	COG0454	-acetyltransferase
C2I25_RS08550	COG0456	acetyltransferase
C2I25_RS08565	COG5002	protein histidine kinase activity
C2I25_RS08575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_RS08580	COG0697	spore germination
C2I25_RS08590	COG0281	malic enzyme
C2I25_RS08595	COG3493	citrate carrier protein
C2I25_RS08600	COG4565	transcriptional regulatory protein
C2I25_RS08605	COG3290	protein histidine kinase activity
C2I25_RS08615	COG4990	cell redox homeostasis
C2I25_RS08625	COG5002	protein histidine kinase activity
C2I25_RS08630	COG0745	RESPONSE REGULATOR receiver
C2I25_RS08635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2I25_RS08645	COG0395	ABC-type sugar transport system, permease component
C2I25_RS08650	COG1175	transmembrane transport
C2I25_RS08655	COG3842	ATPase activity
C2I25_RS08660	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2I25_RS08685	COG2851	Citrate transporter
C2I25_RS08690	COG4565	transcriptional regulatory protein
C2I25_RS08695	COG3290	protein histidine kinase activity
C2I25_RS08705	COG2268	Band 7 protein
C2I25_RS08710	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2I25_RS08720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2I25_RS08725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS08750	COG2766	serine protein kinase
C2I25_RS08765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2I25_RS08790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2I25_RS08915	COG0735	belongs to the Fur family
C2I25_RS08920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2I25_RS08940	COG4555	ABC transporter
C2I25_RS08950	COG0067	glutamate synthase
C2I25_RS08950	COG0069	glutamate synthase activity
C2I25_RS08950	COG0070	glutamate synthase
C2I25_RS08955	COG4129	membrane
C2I25_RS08960	COG1132	(ABC) transporter
C2I25_RS08965	COG3557	Belongs to the UPF0374 family
C2I25_RS08985	COG1194	a g-specific adenine glycosylase
C2I25_RS08990	COG1988	membrane-bound metal-dependent
C2I25_RS09020	COG1090	epimerase
C2I25_RS09025	COG1228	amidohydrolase
C2I25_RS09045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2I25_RS09060	COG0463	Glycosyl transferase, family 2
C2I25_RS09065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I25_RS09065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2I25_RS09075	COG1216	Glycosyl transferase, family 2
C2I25_RS09090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I25_RS09095	COG1263	PTS System
C2I25_RS09095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_RS09135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I25_RS09140	COG0833	amino acid
C2I25_RS09150	COG3829	transcription factor binding
C2I25_RS09165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2I25_RS09170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2I25_RS09190	COG0535	radical SAM domain protein
C2I25_RS09200	COG0387	Pfam Sodium calcium exchanger
C2I25_RS09205	COG3871	stress protein (general stress protein 26)
C2I25_RS09220	COG0586	Pfam SNARE associated Golgi protein
C2I25_RS09240	COG0697	spore germination
C2I25_RS09245	COG2217	Heavy metal translocating P-type atpase
C2I25_RS09255	COG1295	ribonuclease BN
C2I25_RS09265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2I25_RS09280	COG3853	Toxic anion resistance protein (TelA)
C2I25_RS09290	COG0861	Integral membrane protein TerC family
C2I25_RS09295	COG2310	stress, protein
C2I25_RS09300	COG2310	stress, protein
C2I25_RS09305	COG2310	stress, protein
C2I25_RS09335	COG2270	Major facilitator Superfamily
C2I25_RS09385	COG0488	(ABC) transporter
C2I25_RS09390	COG1116	anion transmembrane transporter activity
C2I25_RS09400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I25_RS09420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2I25_RS09450	COG2190	(PTS) system
C2I25_RS09450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_RS09450	COG1263	PTS System
C2I25_RS09455	COG0366	Alpha amylase catalytic
C2I25_RS09460	COG0277	FAD linked oxidase domain protein
C2I25_RS09470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I25_RS09475	COG0549	Belongs to the carbamate kinase family
C2I25_RS09500	COG0840	transmembrane signaling receptor activity
C2I25_RS09505	COG1126	abc transporter atp-binding protein
C2I25_RS09510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I25_RS09515	COG0765	amino acid transport
C2I25_RS09525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I25_RS09525	COG0723	plastoquinol--plastocyanin reductase activity
C2I25_RS09530	COG2814	Major facilitator Superfamily
C2I25_RS09535	COG3541	Predicted nucleotidyltransferase
C2I25_RS09555	COG5002	protein histidine kinase activity
C2I25_RS09580	COG0166	Belongs to the GPI family
C2I25_RS09595	COG0492	ferredoxin-NADP+ reductase activity
C2I25_RS09605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_RS09610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_RS09615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_RS09635	COG0450	alkyl hydroperoxide reductase
C2I25_RS09650	COG1473	amidohydrolase
C2I25_RS09655	COG1757	Na H antiporter
C2I25_RS09680	COG4807	Protein conserved in bacteria
C2I25_RS09695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2I25_RS09705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_RS09720	COG2309	aminopeptidase activity
C2I25_RS09730	COG2076	Multidrug Resistance protein
C2I25_RS09735	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_RS09745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2I25_RS09750	COG0546	phosphoglycolate phosphatase activity
C2I25_RS09755	COG1597	lipid kinase activity
C2I25_RS09775	COG4682	membrane
C2I25_RS09780	COG1846	Transcriptional regulator
C2I25_RS09785	COG0003	Pfam Anion-transporting ATPase
C2I25_RS09800	COG1464	Belongs to the NlpA lipoprotein family
C2I25_RS09805	COG2011	ABC-type metal ion transport system permease component
C2I25_RS09820	COG1335	isochorismatase
C2I25_RS09840	COG4851	CamS sex pheromone cAM373 precursor
C2I25_RS09850	COG0210	DNA helicase
C2I25_RS09875	COG0583	DNA-binding transcription factor activity
C2I25_RS09885	COG0151	Belongs to the GarS family
C2I25_RS09895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2I25_RS09905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2I25_RS09920	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2I25_RS09930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2I25_RS09935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2I25_RS09940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2I25_RS09965	COG0697	spore germination
C2I25_RS09985	COG1215	transferase activity, transferring glycosyl groups
C2I25_RS09995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I25_RS10035	COG0506	proline dehydrogenase activity
C2I25_RS10040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_RS10060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2I25_RS10085	COG5002	protein histidine kinase activity
C2I25_RS10095	COG2252	PERMEase
C2I25_RS10115	COG1266	CAAX protease self-immunity
C2I25_RS10130	COG0488	(ABC) transporter
C2I25_RS10140	COG0456	acetyltransferase
C2I25_RS10145	COG1214	PFAM Peptidase M22, glycoprotease
C2I25_RS10150	COG0802	atpase or kinase
C2I25_RS10250	COG2183	response to ionizing radiation
C2I25_RS10255	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2I25_RS10260	COG0864	Transcriptional regulator
C2I25_RS10265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2I25_RS10270	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2I25_RS10280	COG0705	Rhomboid family
C2I25_RS10285	COG4294	response to UV
C2I25_RS10295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2I25_RS10305	COG2814	Major facilitator Superfamily
C2I25_RS10310	COG0531	amino acid
C2I25_RS10320	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2I25_RS10325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C2I25_RS10355	COG0561	phosphatase activity
C2I25_RS10360	COG4608	Belongs to the ABC transporter superfamily
C2I25_RS10365	COG0444	Belongs to the ABC transporter superfamily
C2I25_RS10370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I25_RS10375	COG0601	transmembrane transport
C2I25_RS10380	COG0747	negative chemotaxis
C2I25_RS10395	COG0488	(ABC) transporter
C2I25_RS10420	COG5298	Protein conserved in bacteria
C2I25_RS10440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_RS10450	COG1609	Transcriptional regulator
C2I25_RS10465	COG0204	Acyl-transferase
C2I25_RS10485	COG0697	spore germination
C2I25_RS10505	COG1910	domain protein
C2I25_RS10510	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2I25_RS10515	COG4149	molybdate abc transporter
C2I25_RS10535	COG0656	L-ascorbic acid biosynthetic process
C2I25_RS10540	COG4166	transmembrane transport
C2I25_RS10545	COG4166	transmembrane transport
C2I25_RS10560	COG4166	transmembrane transport
C2I25_RS10565	COG4608	Belongs to the ABC transporter superfamily
C2I25_RS10570	COG0444	Belongs to the ABC transporter superfamily
C2I25_RS10575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I25_RS10580	COG0601	transmembrane transport
C2I25_RS10600	COG2814	Major facilitator Superfamily
C2I25_RS10610	COG2271	Major facilitator Superfamily
C2I25_RS10615	COG0277	FAD linked oxidase domain protein
C2I25_RS10625	COG0604	alcohol dehydrogenase
C2I25_RS10630	COG1464	Belongs to the NlpA lipoprotein family
C2I25_RS10635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2I25_RS10640	COG2011	ABC-type metal ion transport system permease component
C2I25_RS10645	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS10685	COG4856	YbbR-like protein
C2I25_RS10690	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2I25_RS10775	COG0726	polysaccharide deacetylase
C2I25_RS10780	COG2194	sulfuric ester hydrolase activity
C2I25_RS10790	COG0489	protein tyrosine kinase activity
C2I25_RS10795	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I25_RS10820	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2I25_RS10855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2I25_RS10865	COG0024	Methionine aminopeptidase
C2I25_RS10875	COG0201	protein transport
C2I25_RS10935	COG0255	Belongs to the universal ribosomal protein uL29 family
C2I25_RS10975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2I25_RS10980	COG0051	transcription antitermination factor activity, RNA binding
C2I25_RS11005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2I25_RS11010	COG1358	cellular component organization or biogenesis
C2I25_RS11015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2I25_RS11025	COG2813	Specifically methylates the guanine in position
C2I25_RS11030	COG0222	ribosome binding
C2I25_RS11045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2I25_RS11050	COG0250	Participates in transcription elongation, termination and antitermination
C2I25_RS11055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2I25_RS11070	COG3688	RNA-binding protein containing a PIN domain
C2I25_RS11075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2I25_RS11090	COG1045	serine acetyltransferase
C2I25_RS11110	COG4956	integral membrane protein (PIN domain superfamily)
C2I25_RS11120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2I25_RS11125	COG0542	response to heat
C2I25_RS11135	COG3880	PFAM UvrB UvrC protein
C2I25_RS11225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2I25_RS11230	COG1396	sequence-specific DNA binding
C2I25_RS11235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2I25_RS11240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2I25_RS11245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2I25_RS11250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I25_RS11255	COG0512	Glutamine amidotransferase of anthranilate synthase
C2I25_RS11260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2I25_RS11265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I25_RS11280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2I25_RS11285	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2I25_RS11295	COG2208	phosphoserine phosphatase activity
C2I25_RS11310	COG1098	S1 RNA binding domain
C2I25_RS11330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2I25_RS11335	COG3956	TIGRFAM MazG family protein
C2I25_RS11340	COG2244	polysaccharide biosynthetic process
C2I25_RS11345	COG2002	toxin-antitoxin pair type II binding
C2I25_RS11350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2I25_RS11380	COG0251	oxidation-reduction process
C2I25_RS11385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2I25_RS11400	COG4466	Protein conserved in bacteria
C2I25_RS11420	COG0084	hydrolase, TatD family'
C2I25_RS11430	COG2002	toxin-antitoxin pair type II binding
C2I25_RS11435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2I25_RS11445	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2I25_RS11455	COG1774	PSP1 C-terminal conserved region
C2I25_RS11460	COG0470	DNA polymerase III
C2I25_RS11470	COG1982	Orn Lys Arg decarboxylase major
C2I25_RS11525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2I25_RS11535	COG0590	tRNA wobble adenosine to inosine editing
C2I25_RS11545	COG1335	isochorismatase
C2I25_RS11550	COG1428	Deoxynucleoside kinase
C2I25_RS11555	COG1428	Deoxynucleoside kinase
C2I25_RS11585	COG1686	Belongs to the peptidase S11 family
C2I25_RS11590	COG0516	GMP reductase activity
C2I25_RS11590	COG0517	IMP dehydrogenase activity
C2I25_RS11625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2I25_RS11630	COG0187	DNA topoisomerase II activity
C2I25_RS11640	COG2501	S4 domain
C2I25_RS11645	COG0592	DNA-directed DNA polymerase activity
C2I25_RS11655	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2I25_RS11670	COG1847	R3H domain protein
C2I25_RS11695	COG1192	Involved in chromosome partitioning
C2I25_RS11700	COG1475	DNA binding
C2I25_RS11710	COG0668	transmembrane transport
C2I25_RS11715	COG4481	Protein conserved in bacteria
C2I25_RS11720	COG0012	GTP binding
C2I25_RS11730	COG0629	single-stranded DNA binding
C2I25_RS11740	COG4241	membrane
C2I25_RS11745	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C2I25_RS11755	COG0305	Participates in initiation and elongation during chromosome replication
C2I25_RS11785	COG0745	RESPONSE REGULATOR receiver
C2I25_RS11790	COG5002	protein histidine kinase activity
C2I25_RS11800	COG4853	Protein conserved in bacteria
C2I25_RS11805	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2I25_RS11810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I25_RS11825	COG5002	protein histidine kinase activity
C2I25_RS11860	COG1272	protein, Hemolysin III
C2I25_RS11890	COG0515	serine threonine protein kinase
C2I25_RS11895	COG1132	(ABC) transporter
C2I25_RS11900	COG1695	Transcriptional regulator
C2I25_RS11920	COG2801	Transposase and inactivated derivatives
C2I25_RS11925	COG2801	Transposase and inactivated derivatives
C2I25_RS11930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2I25_RS11960	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C2I25_RS11965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2I25_RS11970	COG2814	Major facilitator Superfamily
C2I25_RS11975	COG3275	phosphorelay sensor kinase activity
C2I25_RS11995	COG0628	permease
C2I25_RS12000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2I25_RS12000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2I25_RS12005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2I25_RS12010	COG1309	transcriptional regulator
C2I25_RS12015	COG0463	Glycosyl transferase, family 2
C2I25_RS12030	COG0488	(ABC) transporter
C2I25_RS12040	COG1216	Glycosyl transferase, family 2
C2I25_RS12050	COG1607	acyl-coa hydrolase
C2I25_RS12060	COG0840	transmembrane signaling receptor activity
C2I25_RS12075	COG0438	transferase activity, transferring glycosyl groups
C2I25_RS12085	COG0477	Major facilitator Superfamily
C2I25_RS12090	COG3279	Response regulator of the LytR AlgR family
C2I25_RS12095	COG1966	Carbon starvation protein
C2I25_RS12100	COG2879	small protein
C2I25_RS12105	COG3706	GGDEF domain
C2I25_RS12110	COG0351	phosphomethylpyrimidine kinase
C2I25_RS12115	COG4585	Histidine kinase
C2I25_RS12115	COG2203	Gaf domain
C2I25_RS12120	COG2197	response regulator
C2I25_RS12130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I25_RS12135	COG1011	Hydrolase
C2I25_RS12145	COG2873	o-acetylhomoserine
C2I25_RS12155	COG0460	homoserine dehydrogenase
C2I25_RS12165	COG1609	Transcriptional regulator
C2I25_RS12170	COG2755	lipolytic protein G-D-S-L family
C2I25_RS12175	COG1131	(ABC) transporter
C2I25_RS12180	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2I25_RS12190	COG2814	Major facilitator Superfamily
C2I25_RS12195	COG0561	phosphatase activity
C2I25_RS12200	COG2233	PERMEase
C2I25_RS12205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2I25_RS12215	COG2363	Small membrane protein
C2I25_RS12225	COG3773	Cell wall hydrolase
C2I25_RS12240	COG0280	phosphate acetyltransferase
C2I25_RS12260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_RS12265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_RS12270	COG1120	ATPase activity
C2I25_RS12275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_RS12280	COG1078	dGTPase activity
C2I25_RS12290	COG1994	Peptidase M50
C2I25_RS12300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I25_RS12305	COG0584	glycerophosphoryl diester phosphodiesterase
C2I25_RS12310	COG0789	Transcriptional regulator
C2I25_RS12315	COG2814	Major facilitator Superfamily
C2I25_RS12345	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2I25_RS12350	COG4506	Protein conserved in bacteria
C2I25_RS12360	COG1595	DNA-templated transcription, initiation
C2I25_RS12380	COG2234	aminopeptidase activity
C2I25_RS12390	COG0024	Methionine aminopeptidase
C2I25_RS12395	COG1131	(ABC) transporter
C2I25_RS12400	COG0842	Transport permease protein
C2I25_RS12405	COG4585	Histidine kinase
C2I25_RS12410	COG2197	response regulator
C2I25_RS12415	COG3227	Zinc metalloprotease (Elastase)
C2I25_RS12430	COG3300	MHYT domain
C2I25_RS12430	COG5001	Diguanylate cyclase
C2I25_RS12440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I25_RS12445	COG2181	nitrate reductase activity
C2I25_RS12445	COG0247	lactate metabolic process
C2I25_RS12450	COG0183	Belongs to the thiolase family
C2I25_RS12455	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2I25_RS12460	COG1960	acyl-CoA dehydrogenase activity
C2I25_RS12465	COG1960	acyl-CoA dehydrogenase activity
C2I25_RS12485	COG4821	SIS domain
C2I25_RS12505	COG1494	fructose-1,6-bisphosphatase
C2I25_RS12510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2I25_RS12550	COG0009	L-threonylcarbamoyladenylate synthase
C2I25_RS12565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2I25_RS12570	COG2259	Doxx family
C2I25_RS12575	COG2190	(PTS) system
C2I25_RS12590	COG0698	ribose 5-phosphate isomerase
C2I25_RS12630	COG0356	it plays a direct role in the translocation of protons across the membrane
C2I25_RS12680	COG3300	MHYT domain
C2I25_RS12680	COG5001	Diguanylate cyclase
C2I25_RS12695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2I25_RS12715	COG0839	Belongs to the complex I subunit 6 family
C2I25_RS12725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2I25_RS12730	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2I25_RS12735	COG1007	ATP synthesis coupled electron transport
C2I25_RS12740	COG4836	Membrane
C2I25_RS12755	COG2385	sporulation resulting in formation of a cellular spore
C2I25_RS12760	COG3279	Response regulator of the LytR AlgR family
C2I25_RS12775	COG0739	heme binding
C2I25_RS12785	COG1609	Transcriptional regulator
C2I25_RS12800	COG0489	protein tyrosine kinase activity
C2I25_RS12805	COG3944	biosynthesis protein
C2I25_RS12810	COG0489	protein tyrosine kinase activity
C2I25_RS12815	COG4464	protein tyrosine phosphatase activity
C2I25_RS12820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2I25_RS12825	COG1086	Polysaccharide biosynthesis protein
C2I25_RS12835	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2I25_RS12845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2I25_RS12850	COG0438	transferase activity, transferring glycosyl groups
C2I25_RS12860	COG1216	Glycosyl transferase, family 2
C2I25_RS12880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2I25_RS12885	COG0745	RESPONSE REGULATOR receiver
C2I25_RS12890	COG5002	protein histidine kinase activity
C2I25_RS12925	COG1136	(ABC) transporter
C2I25_RS12930	COG0577	efflux transmembrane transporter activity
C2I25_RS12970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2I25_RS12975	COG4715	Zinc finger, swim domain protein
C2I25_RS13000	COG3584	3D domain protein
C2I25_RS13000	COG1388	LysM domain
C2I25_RS13010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2I25_RS13020	COG1215	transferase activity, transferring glycosyl groups
C2I25_RS13030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_RS13035	COG0791	NLP P60 protein
C2I25_RS13035	COG1388	LysM domain
C2I25_RS13055	COG1368	sulfuric ester hydrolase activity
C2I25_RS13070	COG2389	metal-binding protein
C2I25_RS13080	COG1620	l-lactate permease
C2I25_RS13115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2I25_RS13120	COG1294	oxidase, subunit
C2I25_RS13125	COG1271	oxidase subunit
C2I25_RS13130	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2I25_RS13135	COG0583	DNA-binding transcription factor activity
C2I25_RS13140	COG1511	domain protein
C2I25_RS13155	COG1301	dicarboxylic acid transport
C2I25_RS13160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I25_RS13170	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I25_RS13190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I25_RS13195	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I25_RS13200	COG1486	melibiose metabolic process
C2I25_RS13220	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2I25_RS13220	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2I25_RS13230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2I25_RS13235	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2I25_RS13240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2I25_RS13245	COG1316	TRANSCRIPTIONal
C2I25_RS13250	COG1739	Uncharacterized protein family UPF0029
C2I25_RS13255	COG1307	EDD domain protein, DegV family
C2I25_RS13265	COG1733	regulation of RNA biosynthetic process
C2I25_RS13270	COG1388	LysM domain
C2I25_RS13270	COG0791	NLP P60 protein
C2I25_RS13275	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2I25_RS13280	COG1040	competence protein
C2I25_RS13285	COG1278	Cold shock
C2I25_RS13290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2I25_RS13315	COG2884	Cell division ATP-binding protein ftsE
C2I25_RS13320	COG2177	Part of the ABC transporter FtsEX involved in
C2I25_RS13325	COG3409	Peptidoglycan-binding domain 1 protein
C2I25_RS13325	COG0793	Belongs to the peptidase S41A family
C2I25_RS13330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I25_RS13335	COG1132	(ABC) transporter
C2I25_RS13345	COG0488	(ABC) transporter
C2I25_RS13350	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2I25_RS13360	COG0583	DNA-binding transcription factor activity
C2I25_RS13380	COG0789	Transcriptional regulator
C2I25_RS13400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2I25_RS13410	COG1950	PFAM Membrane protein of
C2I25_RS13430	COG0110	maltose O-acetyltransferase activity
C2I25_RS13435	COG0457	Tetratricopeptide repeat
C2I25_RS13440	COG0492	ferredoxin-NADP+ reductase activity
C2I25_RS13450	COG1051	belongs to the nudix hydrolase family
C2I25_RS13460	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2I25_RS13470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I25_RS13480	COG2323	membrane
C2I25_RS13495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I25_RS13520	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2I25_RS13535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2I25_RS13570	COG1346	cytolysis
C2I25_RS13575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2I25_RS13580	COG1647	Serine aminopeptidase, S33
C2I25_RS13585	COG0557	exoribonuclease II activity
C2I25_RS13665	COG1335	isochorismatase
C2I25_RS13680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS13730	COG1252	NADH dehydrogenase
C2I25_RS13740	COG1733	regulation of RNA biosynthetic process
C2I25_RS13745	COG2814	Major facilitator Superfamily
C2I25_RS13750	COG0656	L-ascorbic acid biosynthetic process
C2I25_RS13770	COG2910	NAD(P)H-binding
C2I25_RS13775	COG1115	amino acid carrier protein
C2I25_RS13780	COG1115	amino acid carrier protein
C2I25_RS13785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_RS13790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_RS13795	COG2311	Membrane
C2I25_RS13800	COG1528	Iron-storage protein
C2I25_RS13810	COG1611	Belongs to the LOG family
C2I25_RS13815	COG2318	DinB family
C2I25_RS13825	COG0783	Belongs to the Dps family
C2I25_RS13830	COG1115	amino acid carrier protein
C2I25_RS13840	COG0490	domain, Protein
C2I25_RS13845	COG0475	glutathione-regulated potassium exporter activity
C2I25_RS13850	COG0586	Pfam SNARE associated Golgi protein
C2I25_RS13870	COG3227	Zinc metalloprotease (Elastase)
C2I25_RS13875	COG2151	metal-sulfur cluster biosynthetic enzyme
C2I25_RS13880	COG0840	transmembrane signaling receptor activity
C2I25_RS13910	COG5002	protein histidine kinase activity
C2I25_RS13915	COG0745	RESPONSE REGULATOR receiver
C2I25_RS13920	COG1376	ErfK ybiS ycfS ynhG family protein
C2I25_RS13930	COG0586	Pfam SNARE associated Golgi protein
C2I25_RS13975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_RS14000	COG0531	amino acid
C2I25_RS14005	COG2814	Major facilitator Superfamily
C2I25_RS14020	COG0840	transmembrane signaling receptor activity
C2I25_RS14025	COG0011	TIGRFAM Protein of
C2I25_RS14040	COG1686	Belongs to the peptidase S11 family
C2I25_RS14050	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2I25_RS14050	COG1024	Enoyl-CoA hydratase
C2I25_RS14055	COG0183	Belongs to the thiolase family
C2I25_RS14065	COG1960	acyl-CoA dehydrogenase activity
C2I25_RS14070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS14075	COG1309	transcriptional regulator
C2I25_RS14095	COG0039	L-malate dehydrogenase activity
C2I25_RS14140	COG1393	Belongs to the ArsC family
C2I25_RS14155	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2I25_RS14160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I25_RS14175	COG2011	ABC-type metal ion transport system permease component
C2I25_RS14180	COG1464	Belongs to the NlpA lipoprotein family
C2I25_RS14185	COG1464	Belongs to the NlpA lipoprotein family
C2I25_RS14190	COG0396	ATPase activity
C2I25_RS14195	COG0719	Fe-S assembly protein
C2I25_RS14200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2I25_RS14205	COG0822	iron-sulfur transferase activity
C2I25_RS14210	COG0719	Fe-S assembly protein
C2I25_RS14220	COG0737	Belongs to the 5'-nucleotidase family
C2I25_RS14225	COG3377	Domain of unknown function (DUF1805)
C2I25_RS14235	COG0739	heme binding
C2I25_RS14260	COG4377	Putative membrane peptidase family (DUF2324)
C2I25_RS14265	COG0789	Transcriptional regulator
C2I25_RS14275	COG4470	Protein conserved in bacteria
C2I25_RS14295	COG1494	fructose-1,6-bisphosphatase
C2I25_RS14300	COG2445	Protein of unknown function DUF86
C2I25_RS14310	COG0647	UMP catabolic process
C2I25_RS14315	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2I25_RS14330	COG1358	cellular component organization or biogenesis
C2I25_RS14350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2I25_RS14355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2I25_RS14365	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2I25_RS14370	COG4837	Protein of unknown function (DUF1462)
C2I25_RS14420	COG2824	Alkylphosphonate utilization operon protein PhnA
C2I25_RS14430	COG0390	transport system, permease component
C2I25_RS14435	COG2274	protein secretion by the type I secretion system
C2I25_RS14445	COG1252	NADH dehydrogenase
C2I25_RS14460	COG0316	Belongs to the HesB IscA family
C2I25_RS14495	COG1683	Conserved Protein
C2I25_RS14510	COG3708	Transcriptional regulator
C2I25_RS14525	COG1252	NADH dehydrogenase
C2I25_RS14540	COG3584	3D domain protein
C2I25_RS14555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2I25_RS14560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2I25_RS14565	COG1268	BioY protein
C2I25_RS14575	COG2050	protein possibly involved in aromatic compounds catabolism
C2I25_RS14600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2I25_RS14605	COG5018	Exonuclease
C2I25_RS14620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2I25_RS14630	COG2267	carboxylic ester hydrolase activity
C2I25_RS14635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2I25_RS14640	COG1522	sequence-specific DNA binding
C2I25_RS14645	COG0436	Aminotransferase
C2I25_RS14650	COG1098	S1 RNA binding domain
C2I25_RS14655	COG2155	Conserved Protein
C2I25_RS14675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2I25_RS14680	COG1285	pathogenesis
C2I25_RS14825	COG1404	Belongs to the peptidase S8 family
C2I25_RS14845	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2I25_RS14855	COG0058	SHG alpha-glucan phosphorylase activity
C2I25_RS14885	COG1278	Cold shock
C2I25_RS14890	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2I25_RS14895	COG1575	Belongs to the MenA family. Type 1 subfamily
C2I25_RS14900	COG1169	isochorismate synthase
C2I25_RS14910	COG0596	Alpha beta hydrolase
C2I25_RS14915	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2I25_RS14925	COG4948	Mandelate Racemase Muconate Lactonizing
C2I25_RS14945	COG3964	amidohydrolase
C2I25_RS14965	COG2188	Transcriptional regulator
C2I25_RS14990	COG0577	efflux transmembrane transporter activity
C2I25_RS14995	COG1136	(ABC) transporter
C2I25_RS15000	COG0577	efflux transmembrane transporter activity
C2I25_RS15005	COG0577	efflux transmembrane transporter activity
C2I25_RS15010	COG2205	protein histidine kinase activity
C2I25_RS15015	COG0745	RESPONSE REGULATOR receiver
C2I25_RS15020	COG1595	DNA-templated transcription, initiation
C2I25_RS15035	COG0640	Transcriptional regulator
C2I25_RS15040	COG5658	integral membrane protein
C2I25_RS15050	COG2207	Transcriptional regulator
C2I25_RS15050	COG3708	Transcriptional regulator
C2I25_RS15055	COG1136	(ABC) transporter
C2I25_RS15060	COG0577	efflux transmembrane transporter activity
C2I25_RS15070	COG0586	Pfam SNARE associated Golgi protein
C2I25_RS15110	COG1597	lipid kinase activity
C2I25_RS15115	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2I25_RS15140	COG0745	RESPONSE REGULATOR receiver
C2I25_RS15145	COG5002	protein histidine kinase activity
C2I25_RS15150	COG3859	Proton-coupled thiamine transporter YuaJ
C2I25_RS15175	COG1842	Phage shock protein A
C2I25_RS15200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_RS15215	COG1294	oxidase, subunit
C2I25_RS15220	COG1271	oxidase subunit
C2I25_RS15225	COG0288	reversible hydration of carbon dioxide
C2I25_RS15235	COG1854	S-ribosylhomocysteine lyase activity
C2I25_RS15240	COG0789	Transcriptional regulator
C2I25_RS15245	COG2076	Multidrug Resistance protein
C2I25_RS15250	COG2076	Multidrug Resistance protein
C2I25_RS15285	COG0494	nUDIX hydrolase
C2I25_RS15310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I25_RS15315	COG1116	anion transmembrane transporter activity
C2I25_RS15320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2I25_RS15335	COG1368	sulfuric ester hydrolase activity
C2I25_RS15340	COG2267	carboxylic ester hydrolase activity
C2I25_RS15345	COG0753	catalase activity
C2I25_RS15350	COG3852	Histidine kinase
C2I25_RS15355	COG5002	protein histidine kinase activity
C2I25_RS15450	COG0438	transferase activity, transferring glycosyl groups
C2I25_RS15455	COG0671	phosphoesterase, PA-phosphatase related
C2I25_RS15460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2I25_RS15465	COG2267	carboxylic ester hydrolase activity
C2I25_RS15490	COG1794	racemase activity, acting on amino acids and derivatives
C2I25_RS15510	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2I25_RS15515	COG1242	4 iron, 4 sulfur cluster binding
C2I25_RS15535	COG1136	(ABC) transporter
C2I25_RS15545	COG0582	viral genome integration into host DNA
C2I25_RS15550	COG0490	domain, Protein
C2I25_RS15555	COG0475	glutathione-regulated potassium exporter activity
C2I25_RS15560	COG2814	Major facilitator Superfamily
C2I25_RS15600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2I25_RS15610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I25_RS15635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2I25_RS15640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I25_RS15650	COG0303	'Molybdopterin
C2I25_RS15655	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2I25_RS15660	COG0314	molybdopterin synthase activity
C2I25_RS15685	COG1329	Transcriptional regulator
C2I25_RS15710	COG3832	glyoxalase III activity
C2I25_RS15720	COG2814	Major facilitator Superfamily
C2I25_RS15725	COG2081	HI0933 family
C2I25_RS15730	COG2244	polysaccharide biosynthetic process
C2I25_RS15735	COG1187	pseudouridine synthase activity
C2I25_RS15740	COG1349	DNA-binding transcription factor activity
C2I25_RS15745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I25_RS15755	COG1523	belongs to the glycosyl hydrolase 13 family
C2I25_RS15760	COG0510	thiamine kinase activity
C2I25_RS15775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS15785	COG1363	Peptidase, m42
C2I25_RS15790	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C2I25_RS15795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I25_RS15805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2I25_RS15815	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I25_RS15820	COG1674	ftsk spoiiie
C2I25_RS15840	COG1695	Transcriptional regulator
C2I25_RS15845	COG0789	Transcriptional regulator
C2I25_RS15850	COG0697	spore germination
C2I25_RS15855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS15865	COG2309	aminopeptidase activity
C2I25_RS15875	COG3118	belongs to the thioredoxin family
C2I25_RS15880	COG4851	CamS sex pheromone cAM373 precursor
C2I25_RS15885	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2I25_RS15885	COG1605	Chorismate mutase
C2I25_RS15895	COG1605	Chorismate mutase
C2I25_RS15895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2I25_RS15905	COG1609	Transcriptional regulator
C2I25_RS15935	COG0666	response to abiotic stimulus
C2I25_RS15940	COG5002	protein histidine kinase activity
C2I25_RS15945	COG0745	RESPONSE REGULATOR receiver
C2I25_RS15960	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2I25_RS15965	COG0517	IMP dehydrogenase activity
C2I25_RS15970	COG0454	-acetyltransferase
C2I25_RS15975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2I25_RS15990	COG1595	DNA-templated transcription, initiation
C2I25_RS16030	COG0626	cystathionine gamma-synthase activity
C2I25_RS16035	COG1956	GAF domain-containing protein
C2I25_RS16040	COG1309	transcriptional regulator
C2I25_RS16045	COG0697	spore germination
C2I25_RS16050	COG0583	DNA-binding transcription factor activity
C2I25_RS16060	COG1104	cysteine desulfurase activity
C2I25_RS16075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2I25_RS16085	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2I25_RS16105	COG3874	Sporulation protein YtfJ
C2I25_RS16110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2I25_RS16115	COG0827	DNA restriction-modification system
C2I25_RS16140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_RS16180	COG0589	response to stress
C2I25_RS16185	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS16200	COG0662	Cupin 2, conserved barrel domain protein
C2I25_RS16205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS16245	COG0006	proline dipeptidase activity
C2I25_RS16260	COG4109	DRTGG domain
C2I25_RS16275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2I25_RS16290	COG0587	DNA-directed DNA polymerase activity
C2I25_RS16295	COG0281	malic enzyme
C2I25_RS16300	COG1725	Transcriptional regulator
C2I25_RS16325	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2I25_RS16330	COG0628	permease
C2I25_RS16345	COG0372	Belongs to the citrate synthase family
C2I25_RS16350	COG0538	isocitrate dehydrogenase activity
C2I25_RS16375	COG0745	RESPONSE REGULATOR receiver
C2I25_RS16380	COG5002	protein histidine kinase activity
C2I25_RS16385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2I25_RS16385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2I25_RS16395	COG1971	Probably functions as a manganese efflux pump
C2I25_RS16400	COG0237	dephospho-CoA kinase activity
C2I25_RS16405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2I25_RS16415	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2I25_RS16425	COG3611	Membrane attachment protein
C2I25_RS16430	COG1484	DNA-dependent DNA replication
C2I25_RS16445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2I25_RS16470	COG1363	Peptidase, m42
C2I25_RS16475	COG1309	transcriptional regulator
C2I25_RS16480	COG1566	PFAM secretion protein HlyD family protein
C2I25_RS16485	COG2814	Major facilitator Superfamily
C2I25_RS16505	COG1418	mRNA catabolic process
C2I25_RS16515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2I25_RS16520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2I25_RS16560	COG1286	toxin biosynthetic process
C2I25_RS16565	COG1796	DNA polymerase
C2I25_RS16565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2I25_RS16580	COG1187	pseudouridine synthase activity
C2I25_RS16585	COG1114	Component of the transport system for branched-chain amino acids
C2I25_RS16590	COG5386	Cell surface protein
C2I25_RS16600	COG5386	Cell surface protein
C2I25_RS16615	COG1120	ATPase activity
C2I25_RS16620	COG4509	Sortase family
C2I25_RS16630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2I25_RS16635	COG4895	conserved protein (DUF2196)
C2I25_RS16645	COG0745	RESPONSE REGULATOR receiver
C2I25_RS16650	COG2205	protein histidine kinase activity
C2I25_RS16655	COG1131	(ABC) transporter
C2I25_RS16685	COG2318	DinB family
C2I25_RS16710	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_RS16715	COG1309	transcriptional regulator
C2I25_RS16720	COG1024	Enoyl-CoA hydratase
C2I25_RS16725	COG2086	electron transfer activity
C2I25_RS16730	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2I25_RS16735	COG3118	belongs to the thioredoxin family
C2I25_RS16745	COG1719	4-vinyl reductase, 4VR
C2I25_RS16750	COG2009	succinate dehydrogenase
C2I25_RS16755	COG1053	succinate dehydrogenase
C2I25_RS16760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2I25_RS16765	COG0824	Thioesterase
C2I25_RS16770	COG1876	peptidase activity
C2I25_RS16780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2I25_RS16785	COG1360	Flagellar Motor Protein
C2I25_RS16790	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C2I25_RS16795	COG4152	abc transporter atp-binding protein
C2I25_RS16800	COG1668	transmembrane transport
C2I25_RS16805	COG1959	2 iron, 2 sulfur cluster binding
C2I25_RS16815	COG0697	spore germination
C2I25_RS16820	COG1396	sequence-specific DNA binding
C2I25_RS16825	COG1983	PspC domain protein
C2I25_RS16830	COG0402	S-adenosylhomocysteine deaminase activity
C2I25_RS16835	COG2233	PERMEase
C2I25_RS16840	COG2197	response regulator
C2I25_RS16850	COG1309	transcriptional regulator
C2I25_RS16870	COG5401	PFAM Sporulation and spore germination
C2I25_RS16885	COG0622	Phosphoesterase
C2I25_RS16940	COG1067	ATP-dependent peptidase activity
C2I25_RS16940	COG0470	DNA polymerase III
C2I25_RS16955	COG1764	response to oxidative stress
C2I25_RS16960	COG1846	Transcriptional regulator
C2I25_RS16970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2I25_RS16980	COG1587	Uroporphyrinogen-III synthase
C2I25_RS16985	COG0113	porphobilinogen synthase activity
C2I25_RS16995	COG1388	LysM domain
C2I25_RS17010	COG0285	dihydrofolate synthase activity
C2I25_RS17030	COG1077	Cell shape determining protein MreB Mrl
C2I25_RS17050	COG2894	cell division
C2I25_RS17055	COG0739	heme binding
C2I25_RS17060	COG1994	Peptidase M50
C2I25_RS17065	COG1530	ribonuclease E activity
C2I25_RS17075	COG2868	ribosomal protein
C2I25_RS17085	COG3290	protein histidine kinase activity
C2I25_RS17095	COG0745	RESPONSE REGULATOR receiver
C2I25_RS17100	COG5002	protein histidine kinase activity
C2I25_RS17105	COG1136	(ABC) transporter
C2I25_RS17110	COG0577	efflux transmembrane transporter activity
C2I25_RS17115	COG0577	efflux transmembrane transporter activity
C2I25_RS17120	COG0077	Prephenate dehydratase
C2I25_RS17125	COG2258	MOSC domain
C2I25_RS17130	COG1827	regulation of RNA biosynthetic process
C2I25_RS17135	COG1104	cysteine desulfurase activity
C2I25_RS17140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2I25_RS17145	COG0157	Belongs to the NadC ModD family
C2I25_RS17175	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2I25_RS17205	COG1862	Preprotein translocase
C2I25_RS17215	COG2323	membrane
C2I25_RS17220	COG2244	polysaccharide biosynthetic process
C2I25_RS17230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2I25_RS17230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2I25_RS17235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2I25_RS17240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2I25_RS17240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2I25_RS17250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2I25_RS17275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2I25_RS17295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2I25_RS17300	COG1959	2 iron, 2 sulfur cluster binding
C2I25_RS17305	COG1104	cysteine desulfurase activity
C2I25_RS17320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2I25_RS17340	COG0628	permease
C2I25_RS17355	COG4472	Bacterial protein of unknown function (DUF965)
C2I25_RS17370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2I25_RS17375	COG4122	O-methyltransferase activity
C2I25_RS17380	COG0826	peptidase U32
C2I25_RS17385	COG0826	peptidase U32
C2I25_RS17400	COG0768	penicillin binding
C2I25_RS17425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I25_RS17430	COG0626	cystathionine gamma-synthase activity
C2I25_RS17435	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_RS17435	COG1454	alcohol dehydrogenase
C2I25_RS17450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_RS17495	COG2259	Doxx family
C2I25_RS17500	COG2514	catechol 2,3-dioxygenase activity
C2I25_RS17510	COG3186	Phenylalanine-4-hydroxylase
C2I25_RS17515	COG1404	Belongs to the peptidase S8 family
C2I25_RS17550	COG2267	carboxylic ester hydrolase activity
C2I25_RS17560	COG1785	Belongs to the alkaline phosphatase family
C2I25_RS17570	COG2357	RelA SpoT domain protein
C2I25_RS17575	COG0778	Nitroreductase
C2I25_RS17585	COG1595	DNA-templated transcription, initiation
C2I25_RS17610	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2I25_RS17615	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2I25_RS17625	COG1534	Rna-binding protein
C2I25_RS17635	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2I25_RS17640	COG0799	negative regulation of ribosome biogenesis
C2I25_RS17645	COG2226	methyltransferase
C2I25_RS17650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I25_RS17655	COG1596	polysaccharide export
C2I25_RS17655	COG1555	photosystem II stabilization
C2I25_RS17660	COG2131	deaminase
C2I25_RS17665	COG0658	competence protein
C2I25_RS17665	COG2333	competence protein COMEC
C2I25_RS17675	COG1466	dna polymerase III delta subunit
C2I25_RS17700	COG1733	regulation of RNA biosynthetic process
C2I25_RS17705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2I25_RS17735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2I25_RS17740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2I25_RS17750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2I25_RS17755	COG1610	YqeY-like protein
C2I25_RS17775	COG1702	phosphate starvation-inducible protein PhoH
C2I25_RS17780	COG1480	7TM receptor with intracellular HD hydrolase
C2I25_RS17790	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2I25_RS17795	COG0295	cytidine deaminase activity
C2I25_RS17800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2I25_RS17815	COG0517	IMP dehydrogenase activity
C2I25_RS17835	COG0358	DNA primase activity
C2I25_RS17840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2I25_RS17850	COG2384	SAM-dependent methyltransferase
C2I25_RS17855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2I25_RS17885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_RS17890	COG1121	(ABC) transporter
C2I25_RS17895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2I25_RS17900	COG0735	belongs to the Fur family
C2I25_RS17915	COG5521	maltodextrose utilization protein MalA
C2I25_RS17925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2I25_RS17930	COG0477	Major facilitator Superfamily
C2I25_RS17935	COG0768	penicillin binding
C2I25_RS17940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2I25_RS17945	COG0573	inorganic phosphate transmembrane transporter activity
C2I25_RS17950	COG0573	inorganic phosphate transmembrane transporter activity
C2I25_RS17965	COG0704	Plays a role in the regulation of phosphate uptake
C2I25_RS17975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2I25_RS17980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2I25_RS17985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2I25_RS17990	COG4483	Protein conserved in bacteria
C2I25_RS17995	COG1940	carbohydrate kinase activity
C2I25_RS18005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS18025	COG0626	cystathionine gamma-synthase activity
C2I25_RS18030	COG0626	cystathionine gamma-synthase activity
C2I25_RS18035	COG0646	methionine synthase
C2I25_RS18035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2I25_RS18040	COG1410	methionine synthase
C2I25_RS18040	COG0646	methionine synthase
C2I25_RS18110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2I25_RS18115	COG1459	type II secretion system
C2I25_RS18185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2I25_RS18220	COG1725	Transcriptional regulator
C2I25_RS18260	COG2076	Multidrug Resistance protein
C2I25_RS18265	COG2076	Multidrug Resistance protein
C2I25_RS18275	COG1609	Transcriptional regulator
C2I25_RS18285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I25_RS18320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2I25_RS18330	COG3872	metal-dependent enzyme
C2I25_RS18345	COG0006	proline dipeptidase activity
C2I25_RS18370	COG3854	ATPases associated with a variety of cellular activities
C2I25_RS18415	COG0511	ligase activity, forming carbon-carbon bonds
C2I25_RS18420	COG0439	Biotin carboxylase
C2I25_RS18425	COG1302	Protein conserved in bacteria
C2I25_RS18450	COG0142	geranyltranstransferase activity
C2I25_RS18460	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2I25_RS18470	COG0497	DNA recombination
C2I25_RS18475	COG0750	zinc metalloprotease
C2I25_RS18575	COG3093	addiction module antidote protein HigA
C2I25_RS18580	COG0584	glycerophosphoryl diester phosphodiesterase
C2I25_RS18590	COG3290	protein histidine kinase activity
C2I25_RS18590	COG3829	transcription factor binding
C2I25_RS18600	COG0280	phosphate acetyltransferase
C2I25_RS18615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2I25_RS18620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2I25_RS18625	COG0022	dehydrogenase e1 component
C2I25_RS18630	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I25_RS18640	COG0772	Belongs to the SEDS family
C2I25_RS18645	COG2323	membrane
C2I25_RS18665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I25_RS18670	COG0765	amino acid transport
C2I25_RS18675	COG1126	abc transporter atp-binding protein
C2I25_RS18680	COG4129	membrane
C2I25_RS18685	COG1376	ErfK ybiS ycfS ynhG family protein
C2I25_RS18700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS18705	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2I25_RS18720	COG1285	pathogenesis
C2I25_RS18750	COG1760	l-serine dehydratase
C2I25_RS18755	COG1760	l-serine dehydratase
C2I25_RS18760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I25_RS18765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS18770	COG0300	oxidoreductase activity
C2I25_RS18805	COG5444	nuclease activity
C2I25_RS18840	COG1522	sequence-specific DNA binding
C2I25_RS18850	COG0737	Belongs to the 5'-nucleotidase family
C2I25_RS18855	COG1757	Na H antiporter
C2I25_RS18870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2I25_RS18885	COG1073	alpha beta
C2I25_RS18885	COG2226	methyltransferase
C2I25_RS18915	COG0307	riboflavin synthase, alpha
C2I25_RS18920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I25_RS18920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I25_RS18940	COG1073	alpha beta
C2I25_RS18945	COG0456	acetyltransferase
C2I25_RS18950	COG1609	Transcriptional regulator
C2I25_RS18955	COG2056	Na+-H+ antiporter family
C2I25_RS18960	COG0596	Alpha beta hydrolase
C2I25_RS18970	COG0737	Belongs to the 5'-nucleotidase family
C2I25_RS18970	COG4085	toxin activity
C2I25_RS18970	COG1525	nuclease
C2I25_RS18980	COG0456	acetyltransferase
C2I25_RS18980	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2I25_RS18985	COG0656	L-ascorbic acid biosynthetic process
C2I25_RS18990	COG0667	Aldo Keto reductase
C2I25_RS19010	COG1300	Membrane
C2I25_RS19015	COG0735	belongs to the Fur family
C2I25_RS19025	COG4974	Belongs to the 'phage' integrase family
C2I25_RS19050	COG0598	Magnesium transport protein CorA
C2I25_RS19065	COG1846	Transcriptional regulator
C2I25_RS19085	COG1131	(ABC) transporter
C2I25_RS19090	COG1725	Transcriptional regulator
C2I25_RS19100	COG1686	Belongs to the peptidase S11 family
C2I25_RS19120	COG0733	neurotransmitter:sodium symporter activity
C2I25_RS19145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I25_RS19160	COG0697	spore germination
C2I25_RS19165	COG0561	phosphatase activity
C2I25_RS19170	COG4086	secreted protein
C2I25_RS19175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2I25_RS19180	COG0456	acetyltransferase
C2I25_RS19185	COG1547	Domain of unknown function (DUF309)
C2I25_RS19215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2I25_RS19225	COG2188	Transcriptional regulator
C2I25_RS19235	COG3711	transcriptional antiterminator
C2I25_RS19240	COG2190	(PTS) system
C2I25_RS19240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_RS19240	COG1263	PTS System
C2I25_RS19265	COG0778	Nitroreductase
C2I25_RS19270	COG2199	diguanylate cyclase activity
C2I25_RS19280	COG2084	Dehydrogenase
C2I25_RS19315	COG0436	Aminotransferase
C2I25_RS19320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2I25_RS19340	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS19345	COG1695	Transcriptional regulator
C2I25_RS19380	COG0183	Belongs to the thiolase family
C2I25_RS19420	COG3842	ATPase activity
C2I25_RS19425	COG0366	Alpha amylase catalytic
C2I25_RS19435	COG2182	Extracellular solute-binding protein
C2I25_RS19440	COG1175	transmembrane transport
C2I25_RS19445	COG3833	ABC-type maltose transport systems, permease component
C2I25_RS19450	COG1609	Transcriptional regulator
C2I25_RS19455	COG0436	Aminotransferase
C2I25_RS19465	COG2205	protein histidine kinase activity
C2I25_RS19480	COG3209	COG3209 Rhs family protein
C2I25_RS19500	COG2814	Major facilitator Superfamily
C2I25_RS19545	COG1408	metallophosphoesterase
C2I25_RS19550	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS19555	COG2200	EAL domain
C2I25_RS19570	COG4703	Protein of unknown function (DUF1797)
C2I25_RS19580	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C2I25_RS19590	COG0517	IMP dehydrogenase activity
C2I25_RS19595	COG0583	DNA-binding transcription factor activity
C2I25_RS19615	COG0569	domain protein
C2I25_RS19620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2I25_RS19635	COG0561	phosphatase activity
C2I25_RS19650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2I25_RS19655	COG0022	dehydrogenase e1 component
C2I25_RS19700	COG1982	Orn Lys Arg decarboxylase major
C2I25_RS19720	COG0483	inositol monophosphate 1-phosphatase activity
C2I25_RS19730	COG1217	gtp-binding protein TYPA
C2I25_RS19745	COG4896	Protein conserved in bacteria
C2I25_RS19755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2I25_RS19760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2I25_RS19770	COG0772	Belongs to the SEDS family
C2I25_RS19780	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C2I25_RS19815	COG3336	cytochrome c oxidase
C2I25_RS19830	COG2340	Cysteine-rich secretory protein family
C2I25_RS19845	COG0406	alpha-ribazole phosphatase activity
C2I25_RS19850	COG3679	Belongs to the UPF0342 family
C2I25_RS19865	COG0742	ribosomal rna small subunit methyltransferase
C2I25_RS19875	COG3314	Sporulation integral membrane protein YlbJ
C2I25_RS19880	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2I25_RS19885	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2I25_RS19895	COG1399	metal-binding, possibly nucleic acid-binding protein
C2I25_RS19900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2I25_RS19915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2I25_RS19935	COG0768	penicillin binding
C2I25_RS19940	COG0768	penicillin binding
C2I25_RS19960	COG0772	Belongs to the SEDS family
C2I25_RS19980	COG0849	cell division
C2I25_RS19985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2I25_RS19995	COG1191	sigma factor activity
C2I25_RS20000	COG1191	sigma factor activity
C2I25_RS20005	COG1873	PFAM PRC-barrel domain
C2I25_RS20015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2I25_RS20025	COG0762	integral membrane protein
C2I25_RS20030	COG2302	S4 RNA-binding domain
C2I25_RS20035	COG3599	regulation of cell shape
C2I25_RS20055	COG0564	pseudouridine synthase activity
C2I25_RS20120	COG3069	C4-dicarboxylate transmembrane transporter activity
C2I25_RS20140	COG0006	proline dipeptidase activity
C2I25_RS20155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2I25_RS20160	COG1561	YicC-like family, N-terminal region
C2I25_RS20180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2I25_RS20185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2I25_RS20200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2I25_RS20200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2I25_RS20210	COG0631	protein serine/threonine phosphatase activity
C2I25_RS20215	COG2815	serine threonine protein kinase
C2I25_RS20215	COG0515	serine threonine protein kinase
C2I25_RS20225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2I25_RS20230	COG1564	THIamine pyrophosphokinase
C2I25_RS20245	COG1302	Protein conserved in bacteria
C2I25_RS20250	COG1461	Dihydroxyacetone kinase
C2I25_RS20255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2I25_RS20270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2I25_RS20275	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS20280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2I25_RS20290	COG1196	nuclear chromosome segregation
C2I25_RS20295	COG0552	protein localization to endoplasmic reticulum
C2I25_RS20305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2I25_RS20315	COG1837	Belongs to the UPF0109 family
C2I25_RS20355	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2I25_RS20360	COG0758	DNA mediated transformation
C2I25_RS20365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2I25_RS20375	COG4974	Belongs to the 'phage' integrase family
C2I25_RS20420	COG4589	Belongs to the CDS family
C2I25_RS20430	COG0750	zinc metalloprotease
C2I25_RS20455	COG0195	Participates in both transcription termination and antitermination
C2I25_RS20460	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2I25_RS20465	COG1358	cellular component organization or biogenesis
C2I25_RS20475	COG1550	Protein conserved in bacteria
C2I25_RS20480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2I25_RS20490	COG0196	riboflavin kinase activity
C2I25_RS20505	COG0726	polysaccharide deacetylase
C2I25_RS20510	COG0612	Peptidase, M16
C2I25_RS20515	COG1873	PFAM PRC-barrel domain
C2I25_RS20520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2I25_RS20525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2I25_RS20530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2I25_RS20535	COG0527	aspartate kinase activity
C2I25_RS20545	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2I25_RS20550	COG0740	serine-type endopeptidase activity
C2I25_RS20570	COG2188	Transcriptional regulator
C2I25_RS20575	COG1744	ABC transporter substrate-binding protein PnrA-like
C2I25_RS20580	COG3845	ABC transporter
C2I25_RS20585	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2I25_RS20590	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2I25_RS20595	COG0612	Peptidase, M16
C2I25_RS20600	COG0612	Peptidase, M16
C2I25_RS20605	COG0300	oxidoreductase activity
C2I25_RS20620	COG1426	Protein conserved in bacteria
C2I25_RS20625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2I25_RS20650	COG1692	metallophosphoesterase
C2I25_RS20655	COG2359	stage V sporulation protein S
C2I25_RS20665	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2I25_RS20665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2I25_RS20670	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2I25_RS20680	COG4550	Control of competence regulator ComK, YlbF/YmcA
C2I25_RS20705	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2I25_RS20710	COG1368	sulfuric ester hydrolase activity
C2I25_RS20725	COG3773	Cell wall hydrolase
C2I25_RS20735	COG0823	Involved in the tonB-independent uptake of proteins
C2I25_RS20740	COG2723	6-phospho-beta-galactosidase activity
C2I25_RS20745	COG2188	Transcriptional regulator
C2I25_RS20755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_RS20765	COG1346	cytolysis
C2I25_RS20785	COG1086	Polysaccharide biosynthesis protein
C2I25_RS20805	COG5001	Diguanylate cyclase
C2I25_RS20805	COG3300	MHYT domain
C2I25_RS20810	COG2267	carboxylic ester hydrolase activity
C2I25_RS20825	COG2364	Membrane
C2I25_RS20835	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2I25_RS20840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2I25_RS20845	COG2169	Transcriptional regulator
C2I25_RS20850	COG0708	Exodeoxyribonuclease III
C2I25_RS20855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_RS20860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_RS20865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_RS20870	COG1120	ATPase activity
C2I25_RS20875	COG2819	hydrolase of the alpha beta superfamily
C2I25_RS20885	COG1937	Protein conserved in bacteria
C2I25_RS20890	COG2608	mercury ion transmembrane transporter activity
C2I25_RS20895	COG2217	Heavy metal translocating P-type atpase
C2I25_RS20910	COG2116	formate transmembrane transporter activity
C2I25_RS20915	COG1408	metallophosphoesterase
C2I25_RS20930	COG1113	amino acid transport
C2I25_RS20945	COG2322	membrane
C2I25_RS20950	COG1979	alcohol dehydrogenase
C2I25_RS20955	COG1349	DNA-binding transcription factor activity
C2I25_RS20960	COG1105	Belongs to the carbohydrate kinase PfkB family
C2I25_RS20965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I25_RS20965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I25_RS20965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I25_RS20975	COG3584	3D domain protein
C2I25_RS20975	COG1388	LysM domain
C2I25_RS21005	COG0464	growth
C2I25_RS21010	COG2860	membrane
C2I25_RS21015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2I25_RS21020	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C2I25_RS21025	COG0789	Transcriptional regulator
C2I25_RS21030	COG0174	glutamine synthetase
C2I25_RS21035	COG1695	Transcriptional regulator
C2I25_RS21055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2I25_RS21065	COG0737	Belongs to the 5'-nucleotidase family
C2I25_RS21105	COG1132	(ABC) transporter
C2I25_RS21110	COG1132	(ABC) transporter
C2I25_RS21135	COG0730	response to heat
C2I25_RS21150	COG1346	cytolysis
C2I25_RS21160	COG0583	DNA-binding transcription factor activity
C2I25_RS21175	COG1131	(ABC) transporter
C2I25_RS21185	COG1473	amidohydrolase
C2I25_RS21200	COG0785	Cytochrome C biogenesis protein
C2I25_RS21205	COG4846	Membrane protein involved in cytochrome C biogenesis
C2I25_RS21235	COG2226	methyltransferase
C2I25_RS21260	COG0010	Belongs to the arginase family
C2I25_RS21265	COG1329	Transcriptional regulator
C2I25_RS21270	COG1902	pentaerythritol trinitrate reductase activity
C2I25_RS21275	COG0069	glutamate synthase activity
C2I25_RS21280	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I25_RS21285	COG0346	lactoylglutathione lyase activity
C2I25_RS21290	COG0400	carboxylic ester hydrolase activity
C2I25_RS21295	COG5002	protein histidine kinase activity
C2I25_RS21310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_RS21395	COG1131	(ABC) transporter
C2I25_RS21410	COG1136	(ABC) transporter
C2I25_RS21425	COG5002	protein histidine kinase activity
C2I25_RS21435	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_RS21440	COG1268	BioY protein
C2I25_RS21445	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_RS21450	COG0183	Belongs to the thiolase family
C2I25_RS21465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2I25_RS21475	COG2211	Major facilitator Superfamily
C2I25_RS21505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2I25_RS21510	COG2274	protein secretion by the type I secretion system
C2I25_RS21520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I25_RS21545	COG0824	Thioesterase
C2I25_RS21550	COG4841	protein insertion into membrane
C2I25_RS21570	COG0745	RESPONSE REGULATOR receiver
C2I25_RS21575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I25_RS21580	COG1832	CoA-binding protein
C2I25_RS21590	COG0187	DNA topoisomerase II activity
C2I25_RS21595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2I25_RS21600	COG0673	inositol 2-dehydrogenase activity
C2I25_RS21620	COG1131	(ABC) transporter
C2I25_RS21630	COG1595	DNA-templated transcription, initiation
C2I25_RS21640	COG1316	TRANSCRIPTIONal
C2I25_RS21645	COG4166	transmembrane transport
C2I25_RS21650	COG4166	transmembrane transport
C2I25_RS21665	COG4166	transmembrane transport
C2I25_RS21670	COG2226	methyltransferase
C2I25_RS21705	COG0531	amino acid
C2I25_RS21720	COG0697	spore germination
C2I25_RS21730	COG3383	formate dehydrogenase (NAD+) activity
C2I25_RS21735	COG2427	Protein of unknown function (DUF1641)
C2I25_RS21740	COG5609	conserved protein (DUF2294)
C2I25_RS21745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2I25_RS21760	COG2116	formate transmembrane transporter activity
C2I25_RS21765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I25_RS21770	COG0303	'Molybdopterin
C2I25_RS21775	COG0314	molybdopterin synthase activity
C2I25_RS21785	COG0489	protein tyrosine kinase activity
C2I25_RS21800	COG3326	Membrane
C2I25_RS21805	COG2962	Rard protein
C2I25_RS21810	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2I25_RS21815	COG1657	PFAM Prenyltransferase squalene oxidase
C2I25_RS21825	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS21830	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_RS21840	COG4145	pantothenate transmembrane transporter activity
C2I25_RS21855	COG0165	Argininosuccinate lyase
C2I25_RS21865	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS21885	COG1051	belongs to the nudix hydrolase family
C2I25_RS21895	COG0716	FMN binding
C2I25_RS21930	COG2720	vancomycin resistance protein
C2I25_RS21935	COG2514	catechol 2,3-dioxygenase activity
C2I25_RS21945	COG1285	pathogenesis
C2I25_RS21955	COG3852	Histidine kinase
C2I25_RS21980	COG1876	peptidase activity
C2I25_RS21995	COG1309	transcriptional regulator
C2I25_RS22040	COG0457	Tetratricopeptide repeat
C2I25_RS22055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I25_RS22065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2I25_RS22085	COG0697	spore germination
C2I25_RS22100	COG3397	chitin binding
C2I25_RS22105	COG0823	Involved in the tonB-independent uptake of proteins
C2I25_RS22150	COG0584	glycerophosphoryl diester phosphodiesterase
C2I25_RS22165	COG1252	NADH dehydrogenase
C2I25_RS22170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I25_RS22170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS22185	COG0277	FAD linked oxidase domain protein
C2I25_RS22200	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2I25_RS22205	COG2808	Putative FMN-binding domain
C2I25_RS22215	COG0457	Tetratricopeptide repeat
C2I25_RS22225	COG0604	alcohol dehydrogenase
C2I25_RS22230	COG0640	Transcriptional regulator
C2I25_RS22240	COG0584	glycerophosphoryl diester phosphodiesterase
C2I25_RS22265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I25_RS22280	COG3781	membrane
C2I25_RS22300	COG1164	Oligoendopeptidase f
C2I25_RS22305	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2I25_RS22320	COG1193	negative regulation of DNA recombination
C2I25_RS22340	COG0583	DNA-binding transcription factor activity
C2I25_RS22375	COG3739	integral membrane protein
C2I25_RS22380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_RS22385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_RS22390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_RS22405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2I25_RS22410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2I25_RS22455	COG2814	Major facilitator Superfamily
C2I25_RS22460	COG1113	amino acid transport
C2I25_RS22495	COG2072	flavoprotein involved in K transport
C2I25_RS22540	COG1151	hydroxylamine reductase activity
C2I25_RS22595	COG1280	lysine exporter protein (LysE YggA)
C2I25_RS22605	COG1191	sigma factor activity
C2I25_RS22625	COG1733	regulation of RNA biosynthetic process
C2I25_RS22630	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2I25_RS22635	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_RS22650	COG0367	asparagine synthase
C2I25_RS22705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS22725	COG1733	regulation of RNA biosynthetic process
C2I25_RS22730	COG1733	regulation of RNA biosynthetic process
C2I25_RS22735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2I25_RS22740	COG0673	inositol 2-dehydrogenase activity
C2I25_RS22745	COG2188	Transcriptional regulator
C2I25_RS22750	COG1733	regulation of RNA biosynthetic process
C2I25_RS22790	COG0814	amino acid
C2I25_RS22805	COG0659	secondary active sulfate transmembrane transporter activity
C2I25_RS22810	COG2824	Alkylphosphonate utilization operon protein PhnA
C2I25_RS22845	COG2814	Major facilitator Superfamily
C2I25_RS22850	COG0656	L-ascorbic acid biosynthetic process
C2I25_RS22865	COG1733	regulation of RNA biosynthetic process
C2I25_RS22870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2I25_RS22870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2I25_RS22875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I25_RS22875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I25_RS22900	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS22915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I25_RS22920	COG0604	alcohol dehydrogenase
C2I25_RS22925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2I25_RS22930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2I25_RS22935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2I25_RS22940	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2I25_RS22955	COG1070	Carbohydrate kinase
C2I25_RS22960	COG2706	6-phosphogluconolactonase activity
C2I25_RS22965	COG3813	Protein conserved in bacteria
C2I25_RS22970	COG1357	PFAM Pentapeptide repeats (8 copies)
C2I25_RS22980	COG0697	spore germination
C2I25_RS23005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2I25_RS23015	COG0789	Transcriptional regulator
C2I25_RS23020	COG1253	flavin adenine dinucleotide binding
C2I25_RS23050	COG0477	Major facilitator Superfamily
C2I25_RS23060	COG0500	methyltransferase
C2I25_RS23090	COG0628	permease
C2I25_RS23105	COG0110	maltose O-acetyltransferase activity
C2I25_RS23110	COG0738	Major facilitator superfamily
C2I25_RS23115	COG1940	carbohydrate kinase activity
C2I25_RS23120	COG0346	lactoylglutathione lyase activity
C2I25_RS23145	COG2365	Tyrosine phosphatase family
C2I25_RS23155	COG1011	Hydrolase
C2I25_RS23185	COG1131	(ABC) transporter
C2I25_RS23195	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS23215	COG0469	pyruvate kinase activity
C2I25_RS23225	COG0778	Nitroreductase
C2I25_RS23230	COG1733	regulation of RNA biosynthetic process
C2I25_RS23250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2I25_RS23270	COG2356	endonuclease I
C2I25_RS23275	COG1288	antiporter activity
C2I25_RS23330	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2I25_RS23340	COG2031	fatty acid transporter
C2I25_RS23360	COG1131	(ABC) transporter
C2I25_RS23365	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2I25_RS23375	COG2814	Major facilitator Superfamily
C2I25_RS23380	COG1846	Transcriptional regulator
C2I25_RS23395	COG0477	Major facilitator Superfamily
C2I25_RS23405	COG2843	Capsule synthesis protein
C2I25_RS23410	COG1876	peptidase activity
C2I25_RS23430	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2I25_RS23430	COG3409	Peptidoglycan-binding domain 1 protein
C2I25_RS23455	COG2207	Transcriptional regulator
C2I25_RS23455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_RS23465	COG0662	Cupin 2, conserved barrel domain protein
C2I25_RS23485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2I25_RS23505	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2I25_RS23515	COG4990	cell redox homeostasis
C2I25_RS23520	COG0745	RESPONSE REGULATOR receiver
C2I25_RS23525	COG5002	protein histidine kinase activity
C2I25_RS23530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_RS23540	COG3850	Histidine kinase
C2I25_RS23540	COG5002	protein histidine kinase activity
C2I25_RS23560	COG0577	efflux transmembrane transporter activity
C2I25_RS23580	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2I25_RS23590	COG1690	Belongs to the RtcB family
C2I25_RS23600	COG2309	aminopeptidase activity
C2I25_RS23615	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C2I25_RS23640	COG2814	Major facilitator Superfamily
C2I25_RS23680	COG1136	(ABC) transporter
C2I25_RS23720	COG5002	protein histidine kinase activity
C2I25_RS23720	COG3850	Histidine kinase
C2I25_RS23725	COG0745	RESPONSE REGULATOR receiver
C2I25_RS23765	COG1725	Transcriptional regulator
C2I25_RS23770	COG1131	(ABC) transporter
C2I25_RS23805	COG0583	DNA-binding transcription factor activity
C2I25_RS23810	COG0814	amino acid
C2I25_RS23845	COG0346	lactoylglutathione lyase activity
C2I25_RS23860	COG1522	sequence-specific DNA binding
C2I25_RS23865	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS23870	COG1309	transcriptional regulator
C2I25_RS23875	COG2814	Major facilitator Superfamily
C2I25_RS23880	COG1309	transcriptional regulator
C2I25_RS23885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2I25_RS23885	COG3320	Male sterility
C2I25_RS23905	COG2814	Major facilitator Superfamily
C2I25_RS23915	COG0640	Transcriptional regulator
C2I25_RS23920	COG0346	lactoylglutathione lyase activity
C2I25_RS23925	COG0798	PFAM Bile acid sodium symporter
C2I25_RS23935	COG1575	Belongs to the MenA family. Type 1 subfamily
C2I25_RS23940	COG0456	acetyltransferase
C2I25_RS23955	COG5609	conserved protein (DUF2294)
C2I25_RS23960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2I25_RS23970	COG0288	reversible hydration of carbon dioxide
C2I25_RS23975	COG0415	Belongs to the DNA photolyase family
C2I25_RS24000	COG0814	amino acid
C2I25_RS24040	COG0598	Magnesium transport protein CorA
C2I25_RS24045	COG1846	Transcriptional regulator
C2I25_RS24050	COG0583	DNA-binding transcription factor activity
C2I25_RS24070	COG1335	isochorismatase
C2I25_RS24075	COG2267	carboxylic ester hydrolase activity
C2I25_RS24080	COG0737	Belongs to the 5'-nucleotidase family
C2I25_RS24100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2I25_RS24110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2I25_RS24120	COG1063	alcohol dehydrogenase
C2I25_RS24140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS24145	COG0574	Belongs to the PEP-utilizing enzyme family
C2I25_RS24145	COG3848	Pyruvate phosphate dikinase
C2I25_RS24170	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C2I25_RS24190	COG3314	Sporulation integral membrane protein YlbJ
C2I25_RS24205	COG1960	acyl-CoA dehydrogenase activity
C2I25_RS24215	COG0640	Transcriptional regulator
C2I25_RS24220	COG3142	Participates in the control of copper homeostasis
C2I25_RS24230	COG1414	Transcriptional regulator
C2I25_RS24235	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2I25_RS24240	COG1984	allophanate hydrolase subunit 2
C2I25_RS24270	COG0768	penicillin binding
C2I25_RS24305	COG4335	DNA alkylation repair
C2I25_RS24315	COG0833	amino acid
C2I25_RS24325	COG0730	response to heat
C2I25_RS24345	COG0456	acetyltransferase
C2I25_RS24345	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2I25_RS24365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_RS24370	COG0697	spore germination
C2I25_RS24385	COG0456	acetyltransferase
C2I25_RS24410	COG3831	ATPase activity
C2I25_RS24410	COG4884	unkown
C2I25_RS24435	COG1846	Transcriptional regulator
C2I25_RS24440	COG0778	Nitroreductase
C2I25_RS24475	COG0753	catalase activity
C2I25_RS24480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2I25_RS24500	COG0714	Associated with various cellular activities
C2I25_RS24525	COG0346	lactoylglutathione lyase activity
C2I25_RS24530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS24540	COG3279	Response regulator of the LytR AlgR family
C2I25_RS24550	COG4377	Putative membrane peptidase family (DUF2324)
C2I25_RS24570	COG3655	Transcriptional regulator
C2I25_RS24580	COG1785	Belongs to the alkaline phosphatase family
C2I25_RS24585	COG2720	vancomycin resistance protein
C2I25_RS24595	COG3239	Fatty acid desaturase
C2I25_RS24625	COG1414	Transcriptional regulator
C2I25_RS24630	COG4187	Peptidase family M20/M25/M40
C2I25_RS24635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I25_RS24655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_RS24670	COG2329	Antibiotic biosynthesis monooxygenase
C2I25_RS24695	COG1070	Carbohydrate kinase
C2I25_RS24700	COG2390	Transcriptional regulator
C2I25_RS24710	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2I25_RS24715	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2I25_RS24720	COG1879	ABC-type sugar transport system periplasmic component
C2I25_RS24745	COG0277	FAD linked oxidase domain protein
C2I25_RS24760	COG3584	3D domain protein
C2I25_RS24760	COG1388	LysM domain
C2I25_RS24815	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2I25_RS24815	COG1605	Chorismate mutase
C2I25_RS24835	COG0287	Prephenate dehydrogenase
C2I25_RS24850	COG1309	transcriptional regulator
C2I25_RS24855	COG1033	growth of symbiont in host cell
C2I25_RS24855	COG2409	Drug exporters of the RND superfamily
C2I25_RS24860	COG0488	(ABC) transporter
C2I25_RS24865	COG1368	sulfuric ester hydrolase activity
C2I25_RS24870	COG0861	Integral membrane protein TerC family
C2I25_RS24890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS24895	COG0346	lactoylglutathione lyase activity
C2I25_RS24900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I25_RS24905	COG4912	Dna alkylation repair
C2I25_RS24925	COG2318	DinB family
C2I25_RS24935	COG0697	spore germination
C2I25_RS24945	COG2746	aminoglycoside 3-N-acetyltransferase activity
C2I25_RS24985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2I25_RS24990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I25_RS24995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I25_RS25010	COG0628	permease
C2I25_RS25065	COG1131	(ABC) transporter
C2I25_RS25085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2I25_RS25095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2I25_RS25100	COG0436	Aminotransferase
C2I25_RS25140	COG2226	methyltransferase
C2I25_RS25155	COG2261	transglycosylase associated protein
C2I25_RS25180	COG2814	Major facilitator Superfamily
C2I25_RS25180	COG0477	Major facilitator Superfamily
C2I25_RS25185	COG4533	DNA binding
C2I25_RS25190	COG0789	Transcriptional regulator
C2I25_RS25195	COG1664	Polymer-forming cytoskeletal
C2I25_RS25205	COG2814	Major facilitator Superfamily
C2I25_RS25250	COG1307	EDD domain protein, DegV family
C2I25_RS25255	COG1164	Oligoendopeptidase f
C2I25_RS25290	COG0745	RESPONSE REGULATOR receiver
C2I25_RS25295	COG5002	protein histidine kinase activity
C2I25_RS25295	COG3850	Histidine kinase
C2I25_RS25340	COG0667	Aldo Keto reductase
C2I25_RS25355	COG4948	Mandelate Racemase Muconate Lactonizing
C2I25_RS25365	COG4166	transmembrane transport
C2I25_RS25370	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2I25_RS25380	COG0586	Pfam SNARE associated Golgi protein
C2I25_RS25425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I25_RS25430	COG3938	Belongs to the proline racemase family
C2I25_RS25440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2I25_RS25445	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_RS25450	COG1115	amino acid carrier protein
C2I25_RS25455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2I25_RS25470	COG3397	chitin binding
C2I25_RS25495	COG4637	Psort location Cytoplasmic, score
C2I25_RS25530	COG0514	ATP-dependent DNA helicase (RecQ)
C2I25_RS25550	COG3973	AAA domain
C2I25_RS25595	COG2315	Protein conserved in bacteria
C2I25_RS25605	COG2205	protein histidine kinase activity
C2I25_RS25620	COG1819	glycosyl
C2I25_RS25625	COG3397	chitin binding
C2I25_RS25630	COG2153	protein acetylation
C2I25_RS25660	COG4175	Glycine betaine
C2I25_RS25660	COG0517	IMP dehydrogenase activity
C2I25_RS25665	COG4176	ABC-type proline glycine betaine transport system permease component
C2I25_RS25705	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2I25_RS25705	COG0456	acetyltransferase
C2I25_RS25710	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS25720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2I25_RS25725	COG0022	dehydrogenase e1 component
C2I25_RS25730	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I25_RS25735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2I25_RS25750	COG1959	2 iron, 2 sulfur cluster binding
C2I25_RS25765	COG1349	DNA-binding transcription factor activity
C2I25_RS25785	COG3284	Transcriptional regulator
C2I25_RS25815	COG1309	transcriptional regulator
C2I25_RS25855	COG2959	enzyme of heme biosynthesis
C2I25_RS25870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS25900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2I25_RS25910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_RS25915	COG0697	spore germination
C2I25_RS25920	COG0201	protein transport
C2I25_RS25935	COG0737	Belongs to the 5'-nucleotidase family
C2I25_RS25940	COG3227	Zinc metalloprotease (Elastase)
C2I25_RS25945	COG1523	belongs to the glycosyl hydrolase 13 family
C2I25_RS25960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS25965	COG1073	alpha beta
C2I25_RS25970	COG0577	efflux transmembrane transporter activity
C2I25_RS25975	COG1136	(ABC) transporter
C2I25_RS25990	COG5002	protein histidine kinase activity
C2I25_RS25995	COG0745	RESPONSE REGULATOR receiver
C2I25_RS26000	COG1011	Hydrolase
C2I25_RS26025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I25_RS26065	COG0322	excinuclease ABC activity
C2I25_RS26105	COG4667	esterase of the alpha-beta hydrolase superfamily
C2I25_RS26130	COG3878	Protein conserved in bacteria
C2I25_RS26135	COG0251	oxidation-reduction process
C2I25_RS26160	COG0592	DNA-directed DNA polymerase activity
C2I25_RS26180	COG2223	nitrite transmembrane transporter activity
C2I25_RS26190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I25_RS26225	COG0697	spore germination
C2I25_RS26230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_RS26250	COG0584	glycerophosphoryl diester phosphodiesterase
C2I25_RS26275	COG4978	Transcriptional regulator
C2I25_RS26275	COG0789	Transcriptional regulator
C2I25_RS26280	COG2814	Major facilitator Superfamily
C2I25_RS26330	COG0768	penicillin binding
C2I25_RS26335	COG0671	phosphoesterase, PA-phosphatase related
C2I25_RS26340	COG0604	alcohol dehydrogenase
C2I25_RS26345	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2I25_RS26405	COG2205	protein histidine kinase activity
C2I25_RS26430	COG1794	racemase activity, acting on amino acids and derivatives
C2I25_RS26435	COG1819	glycosyl
C2I25_RS26445	COG0768	penicillin binding
C2I25_RS26450	COG5002	protein histidine kinase activity
C2I25_RS26455	COG0561	phosphatase activity
C2I25_RS26495	COG2124	cytochrome p450
C2I25_RS26555	COG3409	Peptidoglycan-binding domain 1 protein
C2I25_RS26555	COG1388	LysM domain
C2I25_RS26555	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2I25_RS26560	COG4824	toxin secretion phage lysis holin
C2I25_RS26615	COG0740	serine-type endopeptidase activity
C2I25_RS26630	COG5484	DNA packaging
C2I25_RS26670	COG0582	viral genome integration into host DNA
C2I25_RS26725	COG2002	toxin-antitoxin pair type II binding
C2I25_RS26745	COG1396	sequence-specific DNA binding
C2I25_RS26765	COG0582	viral genome integration into host DNA
C2I25_RS26795	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2I25_RS26805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_RS26810	COG0460	homoserine dehydrogenase
C2I25_RS26830	COG0577	efflux transmembrane transporter activity
C2I25_RS26835	COG1136	(ABC) transporter
C2I25_RS26845	COG0488	(ABC) transporter
C2I25_RS26855	COG2205	protein histidine kinase activity
C2I25_RS26860	COG0745	RESPONSE REGULATOR receiver
C2I25_RS26870	COG3773	Cell wall hydrolase
C2I25_RS26885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2I25_RS26890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2I25_RS26895	COG2323	membrane
C2I25_RS26915	COG2368	4-hydroxyphenylacetate
C2I25_RS26925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_RS26970	COG1733	regulation of RNA biosynthetic process
C2I25_RS26975	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS27000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2I25_RS27030	COG2207	Transcriptional regulator
C2I25_RS27035	COG3227	Zinc metalloprotease (Elastase)
C2I25_RS27055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2I25_RS27080	COG1686	Belongs to the peptidase S11 family
C2I25_RS27085	COG2318	DinB family
C2I25_RS27100	COG0572	uridine kinase
C2I25_RS27120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2I25_RS27125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2I25_RS27130	COG1024	Enoyl-CoA hydratase
C2I25_RS27135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2I25_RS27140	COG0511	ligase activity, forming carbon-carbon bonds
C2I25_RS27145	COG0439	Biotin carboxylase
C2I25_RS27150	COG1960	acyl-CoA dehydrogenase activity
C2I25_RS27165	COG1309	transcriptional regulator
C2I25_RS27175	COG1131	(ABC) transporter
C2I25_RS27185	COG1408	metallophosphoesterase
C2I25_RS27195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS27205	COG0768	penicillin binding
C2I25_RS27210	COG0768	penicillin binding
C2I25_RS27220	COG1595	DNA-templated transcription, initiation
C2I25_RS27225	COG0768	penicillin binding
C2I25_RS27280	COG2267	carboxylic ester hydrolase activity
C2I25_RS27290	COG5002	protein histidine kinase activity
C2I25_RS27315	COG2207	Transcriptional regulator
C2I25_RS27340	COG0322	excinuclease ABC activity
C2I25_RS27345	COG0531	amino acid
C2I25_RS27350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I25_RS27360	COG0531	amino acid
C2I25_RS27365	COG0697	spore germination
C2I25_RS27380	COG0784	Response regulator, receiver
C2I25_RS27385	COG4191	Histidine kinase
C2I25_RS27395	COG1115	amino acid carrier protein
C2I25_RS27435	COG2814	Major facilitator Superfamily
C2I25_RS27450	COG1686	Belongs to the peptidase S11 family
C2I25_RS27455	COG0110	maltose O-acetyltransferase activity
C2I25_RS27460	COG0730	response to heat
C2I25_RS27470	COG2002	toxin-antitoxin pair type II binding
C2I25_RS27505	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2I25_RS27560	COG1846	Transcriptional regulator
C2I25_RS27565	COG3961	Belongs to the TPP enzyme family
C2I25_RS27580	COG3615	Tellurite resistance protein tehB
C2I25_RS27580	COG0500	methyltransferase
C2I25_RS27620	COG2002	toxin-antitoxin pair type II binding
C2I25_RS27640	COG0582	viral genome integration into host DNA
C2I25_RS27665	COG1309	transcriptional regulator
C2I25_RS27690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS27705	COG1846	Transcriptional regulator
C2I25_RS27725	COG2971	BadF BadG BcrA BcrD
C2I25_RS27750	COG1649	PFAM Uncharacterised BCR, COG1649
C2I25_RS27780	COG1595	DNA-templated transcription, initiation
C2I25_RS27785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2I25_RS27820	COG1396	sequence-specific DNA binding
C2I25_RS27855	COG1132	(ABC) transporter
C2I25_RS27860	COG1132	(ABC) transporter
C2I25_RS27875	COG2258	MOSC domain
C2I25_RS27880	COG0583	DNA-binding transcription factor activity
C2I25_RS27900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2I25_RS27905	COG0583	DNA-binding transcription factor activity
C2I25_RS27915	COG0561	phosphatase activity
C2I25_RS27940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_RS27950	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C2I25_RS27975	COG1247	-acetyltransferase
C2I25_RS28010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_RS28025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I25_RS28055	COG1234	tRNA 3'-trailer cleavage
C2I25_RS28065	COG0028	Belongs to the TPP enzyme family
C2I25_RS28080	COG2814	Major facilitator Superfamily
C2I25_RS28090	COG1136	(ABC) transporter
C2I25_RS28095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2I25_RS28100	COG1187	pseudouridine synthase activity
C2I25_RS28120	COG1115	amino acid carrier protein
C2I25_RS28130	COG2318	DinB family
C2I25_RS28140	COG0776	regulation of translation
C2I25_RS28155	COG2814	Major facilitator Superfamily
C2I25_RS28160	COG3251	PFAM MbtH domain protein
C2I25_RS28165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I25_RS28170	COG1535	isochorismatase
C2I25_RS28170	COG3433	isochorismatase activity
C2I25_RS28175	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2I25_RS28180	COG1169	isochorismate synthase
C2I25_RS28185	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_RS28195	COG2223	nitrite transmembrane transporter activity
C2I25_RS28220	COG0419	ATPase involved in DNA repair
C2I25_RS28225	COG0420	3'-5' exonuclease activity
C2I25_RS28240	COG1024	Enoyl-CoA hydratase
C2I25_RS28245	COG1280	lysine exporter protein (LysE YggA)
C2I25_RS28255	COG2084	Dehydrogenase
C2I25_RS28260	COG1960	acyl-CoA dehydrogenase activity
C2I25_RS28265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2I25_RS28270	COG2079	MmgE PrpD family protein
C2I25_RS28275	COG0372	Belongs to the citrate synthase family
C2I25_RS28280	COG4841	protein insertion into membrane
C2I25_RS28285	COG2814	Major facilitator Superfamily
C2I25_RS28295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I25_RS28295	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2I25_RS28315	COG0300	oxidoreductase activity
C2I25_RS28405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I25_RS28410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2I25_RS28415	COG0671	phosphoesterase, PA-phosphatase related
C2I25_RS28425	COG3064	Membrane
C2I25_RS28425	COG0515	serine threonine protein kinase
C2I25_RS28425	COG4991	sh3 domain protein
C2I25_RS28460	COG1509	lysine 2,3-aminomutase activity
C2I25_RS28465	COG3829	transcription factor binding
C2I25_RS28470	COG0456	acetyltransferase
C2I25_RS28475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I25_RS28480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2I25_RS28485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2I25_RS28490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2I25_RS28505	COG5506	Protein of unknown function (DUF1694)
C2I25_RS28510	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_RS28515	COG1253	flavin adenine dinucleotide binding
C2I25_RS28550	COG5506	Protein of unknown function (DUF1694)
C2I25_RS28555	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_RS28560	COG1253	flavin adenine dinucleotide binding
C2I25_RS28595	COG1174	glycine betaine transport