locus-tag class description HLB41_RS00010 ENOG4105W42 Veg protein HLB41_RS00015 ENOG4105XFA sporulation peptidase YabG HLB41_RS00025 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HLB41_RS00030 ENOG4105F8V Hydrolase, tatD family HLB41_RS00035 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HLB41_RS00040 ENOG4105KRN Transcriptional regulator, abrb family HLB41_RS00045 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HLB41_RS00055 ENOG41060K3 Methyltransferase HLB41_RS00065 ENOG4105MA4 psp1 domain protein HLB41_RS00070 ENOG4105FA2 dna polymerase iii HLB41_RS00080 ENOG4105CXN decarboxylase HLB41_RS00115 ENOG41067KS pro-sigma K processing HLB41_RS00135 ENOG4105C6E dna polymerase iii HLB41_RS00145 ENOG4108Z6B deaminase HLB41_RS00150 ENOG4105GTG Isochorismatase HLB41_RS00160 ENOG4105ZMH deoxynucleoside kinase HLB41_RS00195 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HLB41_RS00230 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLB41_RS00245 ENOG410848D S4 domain protein YaaA HLB41_RS00250 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HLB41_RS00270 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HLB41_RS00280 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HLB41_RS00285 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HLB41_RS00300 ENOG4107QJE Chromosome Partitioning Protein HLB41_RS00305 ENOG4105FA0 parb-like partition protein HLB41_RS00310 ENOG4108ZDA Sporulation protein YyaC HLB41_RS00315 ENOG4105D8X mechanosensitive ion channel HLB41_RS00320 ENOG4105VDK protein, conserved in bacteria HLB41_RS00325 ENOG4105C3G gtp-binding protein HLB41_RS00335 ENOG4108UUM single-stranded DNA-binding protein HLB41_RS00345 ENOG4108XMW Membrane HLB41_RS00350 ENOG4105BZR domain protein HLB41_RS00360 ENOG4105CDU Replicative dna helicase HLB41_RS00365 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HLB41_RS00390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS00395 ENOG4105BZU Histidine kinase HLB41_RS00410 ENOG4105Q2H domain protein HLB41_RS00415 ENOG4105C0H protease HLB41_RS00425 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HLB41_RS00430 ENOG4105BZU Histidine kinase HLB41_RS00440 ENOG4105DPN Oligoendopeptidase f HLB41_RS00445 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) HLB41_RS00450 ENOG4105C1J atp-dependent rna helicase HLB41_RS00460 ENOG4108UT2 hemolysin iii HLB41_RS00465 ENOG4105CMR udp-glucose 4-epimerase HLB41_RS00470 ENOG4105IW1 AmiS UreI transporter HLB41_RS00480 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HLB41_RS00495 ENOG4107RGD Major Facilitator superfamily HLB41_RS00500 ENOG4108HRK Histidine kinase HLB41_RS00505 ENOG4108NEV two component transcriptional regulator, LytTR family HLB41_RS00520 ENOG4106F5Q Membrane HLB41_RS00525 ENOG4105E0X reductase HLB41_RS00535 ENOG41067SE Tetr family transcriptional regulator HLB41_RS00540 ENOG4105C5H ABC transporter HLB41_RS00545 ENOG4105CKK Glycosyl transferase, family 2 HLB41_RS00550 ENOG4105EJV Membrane HLB41_RS00560 ENOG4105K64 Glycosyl transferase, family 2 HLB41_RS00570 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HLB41_RS00575 ENOG4108S4H thioesterase Superfamily protein HLB41_RS00585 ENOG4106YBV Methyl-accepting chemotaxis HLB41_RS00590 ENOG4105EN6 Membrane HLB41_RS00600 ENOG4105CG5 Glycosyl transferase (Group 1 HLB41_RS00610 ENOG41079KZ Major Facilitator Superfamily HLB41_RS00615 ENOG4105DY9 regulatoR HLB41_RS00620 ENOG4105D22 carbon starvation protein HLB41_RS00625 ENOG4105VCD cytoplasmic protein HLB41_RS00630 ENOG4105BZU Histidine kinase HLB41_RS00635 ENOG4105DWF phosphomethylpyrimidine kinase HLB41_RS00640 ENOG4105BZU Histidine kinase HLB41_RS00645 ENOG4105WH1 Two component transcriptional regulator luxr family HLB41_RS00655 ENOG4108Y4K DNA-binding transcriptional activator HLB41_RS00680 ENOG4105D6E homoserine dehydrogenase HLB41_RS00695 ENOG41090WU lipolytic protein G-D-S-L family HLB41_RS00700 ENOG4105CJ1 ABC, transporter HLB41_RS00705 ENOG4108TU7 Inherit from COG: (ABC) transporter HLB41_RS00715 ENOG4105VCH membrane HLB41_RS00720 ENOG410667J hydrolase HLB41_RS00730 ENOG4107SVH Potassium channel protein HLB41_RS00750 ENOG4108VKI Cell wall hydrolase HLB41_RS00765 ENOG4108IJ2 phosphate acetyltransferase HLB41_RS00770 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HLB41_RS00775 ENOG4108VCI transcription factor, rsfa family HLB41_RS00785 ENOG4105DQ5 transport system permease protein HLB41_RS00790 ENOG4105EHG Permease protein HLB41_RS00795 ENOG4105E0A ABC, transporter HLB41_RS00800 ENOG4108MES Periplasmic binding protein HLB41_RS00805 ENOG4105DCI Phosphohydrolase HLB41_RS00810 ENOG41069HH 4-oxalocrotonate tautomerase HLB41_RS00815 ENOG4108Z4T Peptidase M50 HLB41_RS00820 ENOG4108XFG YwhD family HLB41_RS00825 ENOG4105BZ4 penicillin-binding protein HLB41_RS00830 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HLB41_RS00835 ENOG4107SWG transcriptional regulator MERR family HLB41_RS00840 ENOG4105DXB Major Facilitator superfamily HLB41_RS00850 ENOG4105CYW agmatinase HLB41_RS00870 ENOG410684U Domain of unknown function (DUF1934) HLB41_RS00880 ENOG4105DU6 RNA polymerase HLB41_RS00900 ENOG4105IIU Aminopeptidase HLB41_RS00910 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HLB41_RS00915 ENOG4108M15 ABC transporter HLB41_RS00920 ENOG4105KCT ABC transporter HLB41_RS00925 ENOG4105BZU Histidine kinase HLB41_RS00935 ENOG4105D4Y metalloprotease HLB41_RS00950 ENOG4105BZU Histidine kinase HLB41_RS00965 ENOG4105DF6 Fe-S oxidoreductase HLB41_RS00975 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HLB41_RS00980 ENOG4105C1G acyl-Coa dehydrogenase HLB41_RS00985 ENOG4105C1G acyl-Coa dehydrogenase HLB41_RS01000 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HLB41_RS01020 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HLB41_RS01025 ENOG4105CBT Fructose-1,6-bisphosphatase HLB41_RS01030 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HLB41_RS01040 ENOG4107104 thymidine kinase HLB41_RS01045 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HLB41_RS01050 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HLB41_RS01055 ENOG4108ZXQ stage ii sporulation protein r HLB41_RS01065 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HLB41_RS01080 ENOG4107XC4 flavin reductase domain protein, FMN-binding HLB41_RS01085 ENOG4108VGI doxx family HLB41_RS01100 ENOG4108YZG isomerase HLB41_RS01105 ENOG4108UIC UPF0340 protein HLB41_RS01110 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HLB41_RS01130 ENOG41062M3 atp synthase HLB41_RS01135 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HLB41_RS01185 ENOG4105BZU Histidine kinase HLB41_RS01190 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HLB41_RS01200 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HLB41_RS01205 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HLB41_RS01230 ENOG4105D65 subunit l HLB41_RS01235 ENOG4105C8S subunit m HLB41_RS01240 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HLB41_RS01245 ENOG4106778 Protein of unknown function (DUF1146) HLB41_RS01265 ENOG4108IUW ABC transporter HLB41_RS01280 ENOG4105FRN stage II sporulation protein HLB41_RS01290 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HLB41_RS01305 ENOG4107YJ4 chain length determinant protein HLB41_RS01310 ENOG4105HTX biosynthesis protein HLB41_RS01315 ENOG4107YJ4 chain length determinant protein HLB41_RS01320 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HLB41_RS01325 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HLB41_RS01330 ENOG4105D3Q Sugar transferase HLB41_RS01335 ENOG4105K64 Glycosyl transferase, family 2 HLB41_RS01350 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HLB41_RS01355 ENOG4105H93 Acyltransferase family HLB41_RS01365 ENOG4107STW synthase HLB41_RS01370 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HLB41_RS01375 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HLB41_RS01385 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HLB41_RS01390 ENOG4108KGH TRANSCRIPTIONal HLB41_RS01400 ENOG4105CMR udp-glucose 4-epimerase HLB41_RS01405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS01410 ENOG4105BZU Histidine kinase HLB41_RS01425 ENOG4105CXY transporter HLB41_RS01435 ENOG4105C19 ABC transporter HLB41_RS01440 ENOG4107RBB ABC transporter, permease HLB41_RS01450 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_RS01480 ENOG4105C0D helicase HLB41_RS01485 ENOG4105KBK Zinc finger, swim domain protein HLB41_RS01510 ENOG41069ER domain protein HLB41_RS01515 ENOG4105C94 Transporter HLB41_RS01520 ENOG4107R8N Glycosyl transferase, family 2 HLB41_RS01535 ENOG4105K4H Nlp p60 protein HLB41_RS01545 ENOG4105E0M Sulfatase HLB41_RS01555 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) HLB41_RS01565 ENOG4105DAA L-lactate HLB41_RS01570 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HLB41_RS01600 ENOG4107RSM transcriptional regulator HLB41_RS01605 ENOG4105ECB domain protein HLB41_RS01640 ENOG4105VZJ PTS System HLB41_RS01650 ENOG4105VCP PTS System HLB41_RS01655 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HLB41_RS01660 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HLB41_RS01670 ENOG4105CK1 PTS System HLB41_RS01675 ENOG4105VCP PTS System HLB41_RS01680 ENOG4105F8D glycoside hydrolase family 4 HLB41_RS01700 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HLB41_RS01710 ENOG4105ESV Glycosyl transferase, family 4 HLB41_RS01715 ENOG4105C6Y Udp-glucose 6-dehydrogenase HLB41_RS01720 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HLB41_RS01725 ENOG4108KGH TRANSCRIPTIONal HLB41_RS01730 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HLB41_RS01740 ENOG4105KVH Transcriptional regulator HLB41_RS01745 ENOG4105K4H Nlp p60 protein HLB41_RS01755 ENOG41081UC Inherit from COG: Competence protein HLB41_RS01760 ENOG4105VEQ Cold shock protein HLB41_RS01765 ENOG4105MS2 ribosomal subunit Interface protein HLB41_RS01795 ENOG4108RDQ ABC transporter HLB41_RS01820 ENOG4105CAK Cell division ATP-binding protein ftsE HLB41_RS01825 ENOG4105CRP Part of the ABC transporter FtsEX involved in HLB41_RS01830 ENOG4105CN1 protease HLB41_RS01840 ENOG4105BZ1 (ABC) transporter HLB41_RS01855 ENOG4108WS4 fmn reductase HLB41_RS01865 ENOG4105DUM transcriptional regulator, lysR family HLB41_RS01870 ENOG4105HMI Membrane HLB41_RS01885 ENOG4107TXC Transcriptional regulator HLB41_RS01900 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HLB41_RS01905 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HLB41_RS01910 ENOG41086DT Membrane protein of unknown function HLB41_RS01920 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HLB41_RS01930 ENOG4108S4C acetyltransferase HLB41_RS01940 ENOG4105C3M thioredoxin reductase HLB41_RS01950 ENOG4108Z4K mutator MutT protein HLB41_RS01960 ENOG4105CHW UPF0052 protein HLB41_RS01970 ENOG4105KRI phosphocarrier protein (HPr HLB41_RS01980 ENOG4108QY0 Membrane HLB41_RS01995 ENOG4105CZ3 stage V sporulation protein ad HLB41_RS02000 ENOG41090VF Stage v sporulation protein ac HLB41_RS02025 ENOG4105BZU Histidine kinase HLB41_RS02030 ENOG4108IUX (ABC) transporter HLB41_RS02035 ENOG4105RHA ABC transporter, permease HLB41_RS02045 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_RS02095 ENOG41067MG lrgb family HLB41_RS02100 ENOG4105XZU Preprotein translocase, subunit SecG HLB41_RS02110 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HLB41_RS02125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS02140 ENOG4105CM4 permease protein HLB41_RS02145 ENOG4108IPW abc transporter atp-binding protein HLB41_RS02185 ENOG4108MK9 spermidine N(1)-acetyltransferase HLB41_RS02190 ENOG4105C5H ABC transporter HLB41_RS02210 ENOG4105WMR Protein CrcB homolog HLB41_RS02215 ENOG4105WMR Protein CrcB homolog HLB41_RS02235 ENOG4105D4A Cell wall formation (By similarity) HLB41_RS02240 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HLB41_RS02255 ENOG4105KVH Transcriptional regulator HLB41_RS02260 ENOG4105F27 Major Facilitator HLB41_RS02265 ENOG4105CV8 reductase HLB41_RS02280 ENOG4108RYK Nad-dependent epimerase dehydratase HLB41_RS02295 ENOG4105D9N nucleoside HLB41_RS02300 ENOG4105D9N nucleoside HLB41_RS02310 ENOG41090A1 ferritin HLB41_RS02320 ENOG4108URH decarboxylase HLB41_RS02335 ENOG4108RMU ferritin dps family protein HLB41_RS02345 ENOG4105NCW Trka-c domain protein HLB41_RS02350 ENOG4107S91 Sodium hydrogen exchanger HLB41_RS02355 ENOG4107T5V SNARE associated Golgi HLB41_RS02375 ENOG4105D4Y metalloprotease HLB41_RS02380 ENOG4105VG1 fes assembly suf system protein HLB41_RS02385 ENOG4105C8Q Methyl-accepting chemotaxis HLB41_RS02410 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HLB41_RS02425 ENOG4105BZU Histidine kinase HLB41_RS02430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS02435 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HLB41_RS02445 ENOG4107ZTW SNARE associated Golgi HLB41_RS02485 ENOG4107AYK membrAne HLB41_RS02495 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HLB41_RS02515 ENOG4107R7I amino acid HLB41_RS02525 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HLB41_RS02530 ENOG4108SUT Major Facilitator Superfamily HLB41_RS02545 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HLB41_RS02565 ENOG4105DZ1 carboxypeptidase HLB41_RS02580 ENOG4105CHU acetyl-coa acetyltransferase HLB41_RS02585 ENOG4105C1G acyl-Coa dehydrogenase HLB41_RS02590 ENOG4108W8B Beta-lactamase domain protein HLB41_RS02615 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HLB41_RS02635 ENOG41080E8 Transcriptional regulator, Spx MgsR family HLB41_RS02660 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HLB41_RS02665 ENOG4108UMI ABC transporter, permease HLB41_RS02670 ENOG4105D01 (LipO)protein HLB41_RS02675 ENOG4105D01 (LipO)protein HLB41_RS02680 ENOG4105C3K feS assembly ATPase SufC HLB41_RS02685 ENOG4105JRK feS assembly protein SufD HLB41_RS02690 ENOG4105C9B Cysteine desulfurase HLB41_RS02695 ENOG4108UNV SUF system FeS assembly protein, NifU family HLB41_RS02700 ENOG4105DIW FeS assembly protein SUFB HLB41_RS02705 ENOG4107R8B 5'-nucleotidase HLB41_RS02710 ENOG4105KZD Domain of unknown function (DUF1805) HLB41_RS02715 ENOG4108YTE sporulation protein YunB HLB41_RS02720 ENOG4105FAA peptidase M23 HLB41_RS02745 ENOG41090T1 Membrane HLB41_RS02750 ENOG4107TXC Transcriptional regulator HLB41_RS02755 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HLB41_RS02760 ENOG4105MMD transcriptional regulator HLB41_RS02780 ENOG4105CBT Fructose-1,6-bisphosphatase HLB41_RS02795 ENOG4105D4U had-superfamily hydrolase, subfamily iia HLB41_RS02805 ENOG4105DYS nad(p)h dehydrogenase (quinone) HLB41_RS02815 ENOG4108W5N phosphatidylglycerophosphatase a HLB41_RS02830 ENOG41083MR nifu domain-containing protein HLB41_RS02875 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HLB41_RS02880 ENOG4105C4B ABC transporter, permease HLB41_RS02885 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HLB41_RS02910 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HLB41_RS02930 ENOG4105EWC Purine nucleoside phosphorylase HLB41_RS02960 ENOG4105CEP NADH dehydrogenase HLB41_RS02975 ENOG41069ER domain protein HLB41_RS02980 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HLB41_RS02985 ENOG4106YN8 Prenyltransferase HLB41_RS02990 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HLB41_RS03015 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HLB41_RS03030 ENOG4105KA0 thioesterase Superfamily protein HLB41_RS03050 ENOG4107R3E Citrate transporter HLB41_RS03060 ENOG4105Y38 Kinase-associated protein B HLB41_RS03075 ENOG4105C87 Aminotransferase class I and II HLB41_RS03085 ENOG4108MUZ hydrolase HLB41_RS03090 ENOG4105C5I Dehydrogenase HLB41_RS03095 ENOG4108ZB6 transcriptional regulator AsnC family HLB41_RS03100 ENOG4105CHM Aminotransferase HLB41_RS03110 ENOG4105WG9 Conserved Protein HLB41_RS03125 ENOG4107PBV potassium channel HLB41_RS03130 ENOG4105KT7 mgtC SapB transporter HLB41_RS03165 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HLB41_RS03265 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HLB41_RS03280 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HLB41_RS03315 ENOG4105VEQ Cold shock protein HLB41_RS03325 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HLB41_RS03330 ENOG4105E4F Isochorismate synthase HLB41_RS03335 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HLB41_RS03340 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HLB41_RS03345 ENOG4108IPT Naphthoate synthase HLB41_RS03350 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_RS03355 ENOG4105DTQ mandelate racemase muconate lactonizing HLB41_RS03375 ENOG41069H0 dihydroorotase EC 3.5.2.3 HLB41_RS03400 ENOG4105C6Z Gluconate HLB41_RS03450 ENOG41082BM Transcriptional regulator, arsr family HLB41_RS03460 ENOG41086D8 Transcriptional regulator HLB41_RS03465 ENOG4105C19 ABC transporter HLB41_RS03480 ENOG4107ZTW SNARE associated Golgi HLB41_RS03495 ENOG4105C19 ABC transporter HLB41_RS03540 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HLB41_RS03545 ENOG4108UGV hypoxanthine phosphoribosyltransferase HLB41_RS03570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS03575 ENOG4105BZU Histidine kinase HLB41_RS03605 ENOG41087YS Phage shock protein A HLB41_RS03640 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HLB41_RS03645 ENOG4105C4M (Ubiquinol oxidase) subunit I HLB41_RS03650 ENOG4108V2W Carbonate dehydratase HLB41_RS03715 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HLB41_RS03725 ENOG4105D2X ABC transporter substrate-binding protein HLB41_RS03740 ENOG4107T7U Sulfatase HLB41_RS03745 ENOG4107S9D Alpha beta hydrolase HLB41_RS03755 ENOG4105CH6 catalase HLB41_RS03760 ENOG4105BZU Histidine kinase HLB41_RS03765 ENOG4105BZU Histidine kinase HLB41_RS03810 ENOG4108MK9 spermidine N(1)-acetyltransferase HLB41_RS03820 ENOG4105EPU Molybdenum cofactor synthesis domain protein HLB41_RS03830 ENOG4105BZF Glycosyl transferase (Group 1 HLB41_RS03835 ENOG4105YVM Phosphoesterase, PA-phosphatase related HLB41_RS03840 ENOG4108Z0R Transferase HLB41_RS03845 ENOG4105E8V Alpha Beta Hydrolase Fold protein HLB41_RS03870 ENOG4105CIG ABC transporter HLB41_RS03880 ENOG4105N5T Radical SAM Protein HLB41_RS03900 ENOG4105C19 ABC transporter HLB41_RS03915 ENOG4105NCW Trka-c domain protein HLB41_RS03920 ENOG4107S91 Sodium hydrogen exchanger HLB41_RS03925 ENOG410605W Major Facilitator HLB41_RS03930 ENOG4105C8T Leucyl-tRNA synthetase HLB41_RS03955 ENOG4108B31 Spore germination protein HLB41_RS03965 ENOG4105DWV Homoserine O-trans-acetylase HLB41_RS03975 ENOG41085GJ domain protein HLB41_RS03995 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HLB41_RS04000 ENOG4105D06 uba thif-type nad fad binding protein HLB41_RS04010 ENOG4105CVM Molybdenum cofactor synthesis domain protein HLB41_RS04015 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HLB41_RS04020 ENOG4108ZAF Molybdopterin HLB41_RS04035 ENOG4105CSC Glucose uptake protein HLB41_RS04040 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HLB41_RS04045 ENOG4108VJ1 Transcriptional regulator (CarD family HLB41_RS04080 ENOG4105CBX hi0933 family HLB41_RS04095 ENOG4105YW5 deoR family transcriptional regulator HLB41_RS04100 ENOG4107QSE Dipeptidase HLB41_RS04110 ENOG4108IUM Glycogen debranching enzyme HLB41_RS04115 ENOG4108V15 phosphotransferase enzyme family HLB41_RS04130 ENOG4105C8F Beta-lactamase domain protein HLB41_RS04160 ENOG4108VDD TRNA binding domain protein HLB41_RS04170 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HLB41_RS04215 ENOG4105C88 aminopeptidase HLB41_RS04235 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HLB41_RS04240 ENOG4105ETE Transcriptional regulator (LacI family HLB41_RS04270 ENOG4105EP9 oxidoreductase HLB41_RS04275 ENOG4107SNB ankyrin repeat protein YahD HLB41_RS04285 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_RS04300 ENOG4105DGU Histone deacetylase HLB41_RS04305 ENOG4105W87 Cbs domain HLB41_RS04310 ENOG4105F1V Acetoin utilization protein HLB41_RS04320 ENOG4108UW5 maltose o-acetyltransferase HLB41_RS04345 ENOG4108IBT Inherit from COG: transposase HLB41_RS04355 ENOG4105C28 cystathionine HLB41_RS04365 ENOG4105U5Y Transcriptional regulator HLB41_RS04375 ENOG4105RQF LysR family Transcriptional regulator HLB41_RS04400 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HLB41_RS04410 ENOG4105EFZ amidohydrolase HLB41_RS04425 ENOG4105KBJ sporulation protein ytfj HLB41_RS04430 ENOG4106F1P AAA ATPase, central domain protein HLB41_RS04435 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HLB41_RS04445 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HLB41_RS04465 ENOG4108JYZ YitT family HLB41_RS04485 ENOG4105CH7 arginosuccinase HLB41_RS04505 ENOG4107YZX Universal stress protein HLB41_RS04525 ENOG41082W1 Cupin 2, conserved barrel domain protein HLB41_RS04530 ENOG4105Z7P Acetyltransferase (GNAT) family HLB41_RS04565 ENOG4105DC7 peptidase M24 HLB41_RS04570 ENOG4105E8R UPF0173 metal-dependent hydrolase HLB41_RS04595 ENOG4105SFS phosphoesterase RecJ domain protein HLB41_RS04605 ENOG4105VV2 HLB41_RS04610 ENOG4105C0B DNA polymerase III (alpha subunit) HLB41_RS04615 ENOG4105C6K Malic enzyme HLB41_RS04620 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HLB41_RS04645 ENOG4105FS0 cytoplasmic membrane protein HLB41_RS04650 ENOG4108REF Sporulation integral membrane protein ytvi HLB41_RS04660 ENOG4105BZN citrate synthase HLB41_RS04665 ENOG4108HMX isocitrate dehydrogenase (NADP) HLB41_RS04670 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HLB41_RS04685 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_RS04690 ENOG4105BZU Histidine kinase HLB41_RS04695 ENOG4105C2M dna polymerase I HLB41_RS04700 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HLB41_RS04710 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HLB41_RS04715 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HLB41_RS04745 ENOG4108TDW sporulation protein YtxC HLB41_RS04750 ENOG4105C22 threonyL-tRNA synthetase HLB41_RS04755 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HLB41_RS04775 ENOG4105CN9 Peptidase m42 family protein HLB41_RS04780 ENOG4108JGH Tetr family transcriptional regulator HLB41_RS04785 ENOG4105CW7 secretion protein, HlyD family HLB41_RS04790 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLB41_RS04810 ENOG4108RWN rrna methyltransferase HLB41_RS04820 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HLB41_RS04825 ENOG4105C5S asparaginyl-tRNA synthetase HLB41_RS04840 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HLB41_RS04855 ENOG4105DCG PHP domain protein HLB41_RS04865 ENOG4105FE9 pseudouridine synthase HLB41_RS04875 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) HLB41_RS04885 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) HLB41_RS04900 ENOG4105E0A ABC, transporter HLB41_RS04905 ENOG4105KFN sortase, SrtB family HLB41_RS04915 ENOG4105DR4 Methyltransferase HLB41_RS04930 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_RS04975 ENOG4105S6R Iron-hydroxamate transporter permease subunit HLB41_RS04980 ENOG4105J76 Periplasmic binding protein HLB41_RS04990 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_RS04995 ENOG4107Z3H Transcriptional regulator, TetR family HLB41_RS05000 ENOG41060WC Enoyl-CoA hydratase HLB41_RS05005 ENOG4105BZJ Electron transfer flavoprotein HLB41_RS05010 ENOG4105C10 Electron transfer flavoprotein HLB41_RS05015 ENOG4105K63 Thioredoxin HLB41_RS05020 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HLB41_RS05030 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HLB41_RS05040 ENOG4105E33 succinate dehydrogenase HLB41_RS05050 ENOG4108VXD carboxy-peptidase HLB41_RS05055 ENOG4105E14 MotA TolQ exbB proton channel HLB41_RS05060 ENOG4105ER2 Ompa motb domain protein HLB41_RS05065 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HLB41_RS05070 ENOG4108IUX (ABC) transporter HLB41_RS05075 ENOG4105RHA ABC transporter, permease HLB41_RS05080 ENOG4108Z40 Transcriptional regulator HLB41_RS05085 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HLB41_RS05095 ENOG4108JCI Transcriptional regulator HLB41_RS05100 ENOG41067S9 phage shock protein C, PspC HLB41_RS05105 ENOG4105DZC cytosine deaminase HLB41_RS05115 ENOG4105PFC Transcriptional regulator HLB41_RS05140 ENOG4105CUZ uba thif-type nad fad binding protein HLB41_RS05210 ENOG4107ZQN disulfide bond HLB41_RS05215 ENOG4108KF3 Electron transport protein SCO1 SenC HLB41_RS05255 ENOG4105PFC Transcriptional regulator HLB41_RS05265 ENOG4105KBX Transcriptional regulator, TetR family HLB41_RS05275 ENOG4108PCX Major Facilitator HLB41_RS05285 ENOG4108XJQ germination protein HLB41_RS05295 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HLB41_RS05300 ENOG4105M59 Phosphodiesterase, mj0936 family HLB41_RS05320 ENOG4108QCI YvbH-like oligomerisation region HLB41_RS05345 ENOG4108IUQ atp-dependent protease HLB41_RS05365 ENOG4105K56 Transcriptional regulator HLB41_RS05390 ENOG4105D52 delta-aminolevulinic acid dehydratase HLB41_RS05400 ENOG41068KH stage VI sporulation protein D HLB41_RS05410 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HLB41_RS05415 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HLB41_RS05425 ENOG4108Z03 MAF-like protein HLB41_RS05435 ENOG4105DFF Rod shape-determining protein mreb HLB41_RS05455 ENOG4107QMS site-determining protein HLB41_RS05470 ENOG4105C03 ribonuclease HLB41_RS05480 ENOG4105X36 (ribosomal) protein HLB41_RS05495 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HLB41_RS05505 ENOG4105EWM Histidine kinase HLB41_RS05510 ENOG4105C19 ABC transporter HLB41_RS05525 ENOG4105CQC Prephenate dehydratase HLB41_RS05530 ENOG4108RPX mosc domain containing protein HLB41_RS05545 ENOG4108IYU L-aspartate oxidase HLB41_RS05550 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HLB41_RS05555 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HLB41_RS05580 ENOG4108HUF Transporter HLB41_RS05595 ENOG41061AI Protein of unknown function (DUF2905) HLB41_RS05610 ENOG4105VIE preprotein translocase, subunit YajC HLB41_RS05620 ENOG4108QG2 Membrane HLB41_RS05625 ENOG4105CKP Polysaccharide Biosynthesis Protein HLB41_RS05635 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HLB41_RS05640 ENOG41076HS cation diffusion facilitator family transporter HLB41_RS05645 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HLB41_RS05655 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HLB41_RS05660 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HLB41_RS05670 ENOG4105CUT histidyl-tRNA synthetase HLB41_RS05680 ENOG4105CUZ uba thif-type nad fad binding protein HLB41_RS05685 ENOG4108VCI transcription factor, rsfa family HLB41_RS05690 ENOG4105D1H recombination factor protein RarA HLB41_RS05700 ENOG4105C3J Cysteine desulfurase HLB41_RS05705 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HLB41_RS05715 ENOG4105C7H Helicase, RecD TraA family HLB41_RS05720 ENOG41060CR HLB41_RS05735 ENOG4105C02 permease HLB41_RS05745 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HLB41_RS05765 ENOG4105HHA aminodeoxychorismate lyase HLB41_RS05775 ENOG4105XYU peptidase (U32 family) HLB41_RS05780 ENOG4105CFP Peptidase U32 HLB41_RS05790 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HLB41_RS05800 ENOG4107XRG penicillin-binding protein HLB41_RS05830 ENOG4105C28 cystathionine HLB41_RS05835 ENOG4105C0A alcohol dehydrogenase HLB41_RS05845 ENOG4108V5C ABC transporter HLB41_RS05850 ENOG4105S6R Iron-hydroxamate transporter permease subunit HLB41_RS05890 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HLB41_RS05900 ENOG4105MIR Phenylalanine 4-monooxygenase HLB41_RS05905 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HLB41_RS05940 ENOG4108MUZ hydrolase HLB41_RS05945 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HLB41_RS05950 ENOG4105G6Z alkaline phosphatase HLB41_RS05965 ENOG4108TVJ Nitroreductase HLB41_RS05985 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_RS06000 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HLB41_RS06005 ENOG4105CQW ribosome biogenesis GTPase YqeH HLB41_RS06015 ENOG410812S Rna-binding protein HLB41_RS06025 ENOG4108WF2 Metal Dependent Phosphohydrolase HLB41_RS06035 ENOG4105DXX methyltransferase HLB41_RS06045 ENOG4105KQC Competence protein HLB41_RS06050 ENOG4108UK2 deaminase HLB41_RS06055 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HLB41_RS06065 ENOG4105TQK DNA polymerase iii, delta' subunit HLB41_RS06090 ENOG4105KVH Transcriptional regulator HLB41_RS06095 ENOG4105CSA Coproporphyrinogen iii oxidase HLB41_RS06125 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HLB41_RS06130 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HLB41_RS06140 ENOG4105KTH gatB Yqey HLB41_RS06145 ENOG41068P3 sporulation protein YqfC HLB41_RS06155 ENOG4105C9A Phoh family HLB41_RS06160 ENOG4105CTJ Metal Dependent Phosphohydrolase HLB41_RS06165 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HLB41_RS06170 ENOG4107YR5 Diacylglycerol kinase HLB41_RS06175 ENOG4105KG3 cytidine deaminase HLB41_RS06180 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HLB41_RS06205 ENOG4107XJU UPF0178 protein HLB41_RS06210 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HLB41_RS06215 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_RS06230 ENOG4105EGD dinuclear metal center protein, YbgI family HLB41_RS06255 ENOG41069ZM Protein of unknown function (DUF2624) HLB41_RS06260 ENOG4108JYZ YitT family HLB41_RS06265 ENOG4105FDK ABC transporter HLB41_RS06275 ENOG4105N80 Ferric uptake regulator, Fur family HLB41_RS06300 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HLB41_RS06310 ENOG4107RF6 penicillin-binding protein HLB41_RS06315 ENOG4105EXS phosphate abc transporter HLB41_RS06320 ENOG4105C8U phosphate abc transporter HLB41_RS06325 ENOG4105C8U phosphate abc transporter HLB41_RS06330 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HLB41_RS06335 ENOG4108UTW Plays a role in the regulation of phosphate uptake HLB41_RS06350 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HLB41_RS06360 ENOG4105DKQ ROK family HLB41_RS06370 ENOG4105C5X domain protein HLB41_RS06390 ENOG4105C28 cystathionine HLB41_RS06395 ENOG4105C28 cystathionine HLB41_RS06405 ENOG4105C3R Methionine synthase HLB41_RS06410 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HLB41_RS06445 ENOG4107R6U sodium dicarboxylate symporter HLB41_RS06515 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HLB41_RS06545 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HLB41_RS06575 ENOG4105D03 DNA-3-methyladenine glycosylase II HLB41_RS06620 ENOG4105C0D helicase HLB41_RS06650 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HLB41_RS06655 ENOG4105CJ1 ABC, transporter HLB41_RS06690 ENOG41080TC multidrug resistance protein HLB41_RS06715 ENOG4105WZW rhodanese family HLB41_RS06720 ENOG41082GG biotin lipoate A B protein ligase HLB41_RS06750 ENOG4107YBY Hydrolase HLB41_RS06760 ENOG4105CBJ Metal-dependent enzyme HLB41_RS06775 ENOG4105DC7 peptidase M24 HLB41_RS06800 ENOG4105CD2 stage iii sporulation protein aa HLB41_RS06805 ENOG4105KR5 Stage iii sporulation protein HLB41_RS06810 ENOG4108CQH stage III sporulation protein AC HLB41_RS06815 ENOG4105KQ4 Stage iii sporulation protein ad HLB41_RS06825 ENOG410644B Stage III sporulation protein af HLB41_RS06850 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HLB41_RS06855 ENOG4108ZSR alkaline shock protein HLB41_RS06865 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HLB41_RS06880 ENOG4105CTB Polyprenyl synthetase HLB41_RS06890 ENOG4105DX0 Hemolysin A HLB41_RS06895 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HLB41_RS06900 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HLB41_RS06905 ENOG4105S1Z Stage IV sporulation protein B HLB41_RS06910 ENOG4107QQR Sporulation HLB41_RS06925 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HLB41_RS06935 ENOG4108JUB Transcriptional regulator HLB41_RS06945 ENOG4107RDP Dehydrogenase HLB41_RS06950 ENOG4105CKM Branched-chain carboxylic acid kinase HLB41_RS06965 ENOG4105CPP Dehydrogenase, E1 component HLB41_RS06970 ENOG4105C7S Dehydrogenase HLB41_RS06980 ENOG4108QY0 Membrane HLB41_RS06990 ENOG4105G7B Protein of unknown function (DUF2992) HLB41_RS07000 ENOG4108HW3 (ABC) transporter HLB41_RS07005 ENOG4105E5Q amino acid AbC transporter HLB41_RS07010 ENOG4105CDA abc transporter atp-binding protein HLB41_RS07015 ENOG4108QEG Membrane HLB41_RS07020 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HLB41_RS07035 ENOG4105D9U N-acetyltransferase HLB41_RS07040 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HLB41_RS07070 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HLB41_RS07085 ENOG4105EJQ L-serine dehydratase HLB41_RS07090 ENOG4105II7 pyrroline-5-carboxylate reductase HLB41_RS07095 ENOG41069FQ Metallo-beta-lactamase superfamily HLB41_RS07100 ENOG4108IXY short-chain dehydrogenase reductase HLB41_RS07115 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HLB41_RS07130 ENOG4105DBV ornithine carbamoyltransferase HLB41_RS07155 ENOG4105CGH 5'-nucleotidase HLB41_RS07160 ENOG4105DFD Na H antiporter HLB41_RS07170 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HLB41_RS07175 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HLB41_RS07185 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HLB41_RS07190 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HLB41_RS07215 ENOG4108R6K riboflavin synthase, subunit alpha HLB41_RS07220 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HLB41_RS07240 ENOG4108YM7 Gcn5-related n-acetyltransferase HLB41_RS07245 ENOG4105ETE Transcriptional regulator (LacI family HLB41_RS07255 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HLB41_RS07275 ENOG4105RHY Pfam:UPF0157 HLB41_RS07285 ENOG4105CPC Aldo Keto reductase HLB41_RS07305 ENOG4105MZ9 stage II sporulation protein m HLB41_RS07310 ENOG4105I3K Ferric uptake regulator, Fur family HLB41_RS07320 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_RS07345 ENOG4105D7N magnesium and cobalt transport protein CorA HLB41_RS07380 ENOG4105DVE abc transporter atp-binding protein HLB41_RS07385 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HLB41_RS07390 ENOG4105DZ1 carboxypeptidase HLB41_RS07395 ENOG41082AN stage II sporulation protein HLB41_RS07405 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_RS07410 ENOG4105C8J )-transporter HLB41_RS07430 ENOG41090VF Stage v sporulation protein ac HLB41_RS07435 ENOG4105CZ3 stage V sporulation protein ad HLB41_RS07445 ENOG4105G6R Stage v sporulation protein ae HLB41_RS07455 ENOG4105DQF Hydrolase HLB41_RS07460 ENOG4105PTM secreted protein HLB41_RS07465 ENOG4107ZE5 PPIases accelerate the folding of proteins HLB41_RS07500 ENOG4105CE4 GlcNAc 6-P deacetylase HLB41_RS07520 ENOG4105CID antiterminator HLB41_RS07535 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HLB41_RS07555 ENOG4105BZU Histidine kinase HLB41_RS07565 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HLB41_RS07580 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HLB41_RS07595 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HLB41_RS07605 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HLB41_RS07610 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HLB41_RS07625 ENOG4105DTD Dehydrogenase HLB41_RS07630 ENOG4105K7K Transcriptional regulator HLB41_RS07660 ENOG4105CHU acetyl-coa acetyltransferase HLB41_RS07705 ENOG4105CG3 alpha amylase, catalytic region HLB41_RS07715 ENOG4107FKK extracellular solute-binding protein family 1 HLB41_RS07725 ENOG4105EG2 ABC transporter, permease HLB41_RS07730 ENOG4105FKQ transcriptional regulator HLB41_RS07735 ENOG4105CHM Aminotransferase HLB41_RS07745 ENOG4108HGU Histidine kinase HLB41_RS07765 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HLB41_RS07800 ENOG4105UIN HLB41_RS07810 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HLB41_RS07825 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HLB41_RS07830 ENOG4105EPM Diguanylate phosphodiesterase HLB41_RS07845 ENOG4107IN1 Protein of unknown function (DUF1797) HLB41_RS07855 ENOG4108XRC Protein of unknown function (DUF458) HLB41_RS07890 ENOG4107ZYR domain protein HLB41_RS07895 ENOG4105CN5 Metallo-Beta-Lactamase HLB41_RS07905 ENOG4108X4Q Hydrolase HLB41_RS07910 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HLB41_RS07925 ENOG4105CPP Dehydrogenase, E1 component HLB41_RS07975 ENOG4105CXN decarboxylase HLB41_RS07995 ENOG4105ECY inositol monophosphatase HLB41_RS08005 ENOG4105CI3 gtp-binding protein typa HLB41_RS08010 ENOG4105QA2 HLB41_RS08030 ENOG4108IAB Phoh family HLB41_RS08045 ENOG4105CNI cell division protein FtsW HLB41_RS08050 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HLB41_RS08055 ENOG4107VFP cytochrome oxidase assembly HLB41_RS08095 ENOG4105EKQ RNA-directed DNA polymerase HLB41_RS08110 ENOG4106UY4 Inherit from COG: Scp-like extracellular HLB41_RS08125 ENOG4107TB6 phosphoglycerate mutase HLB41_RS08145 ENOG4106H78 methyltransferase HLB41_RS08155 ENOG4105H20 Sporulation integral membrane protein YlbJ HLB41_RS08160 ENOG4105D78 K07001 NTE family protein HLB41_RS08165 ENOG41063PX domain protein HLB41_RS08175 ENOG4105KNH Nucleic acid-binding protein HLB41_RS08200 ENOG41074B2 UPF0747 protein HLB41_RS08215 ENOG4105CJN penicillin-binding protein HLB41_RS08220 ENOG4105CJN penicillin-binding protein HLB41_RS08225 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HLB41_RS08235 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HLB41_RS08240 ENOG4105CNI cell division protein FtsW HLB41_RS08245 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HLB41_RS08250 ENOG4105D4A Cell wall formation (By similarity) HLB41_RS08260 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HLB41_RS08265 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HLB41_RS08275 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_RS08285 ENOG4105WR5 sporulation protein, YlmC YmxH family HLB41_RS08290 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HLB41_RS08295 ENOG4105DFA alanine racemase domain protein HLB41_RS08300 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HLB41_RS08305 ENOG41067XK integral membrane protein HLB41_RS08310 ENOG4105DBK s4 domain protein HLB41_RS08335 ENOG4105C34 Pseudouridine synthase HLB41_RS08355 ENOG4105CD3 dihydroorotase HLB41_RS08365 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HLB41_RS08370 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HLB41_RS08385 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HLB41_RS08410 ENOG4105DC7 peptidase M24 HLB41_RS08425 ENOG4105DSJ YicC domain protein HLB41_RS08445 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HLB41_RS08450 ENOG4105C25 Primosomal protein n' HLB41_RS08465 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HLB41_RS08470 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HLB41_RS08475 ENOG4108ZF3 Phosphatase HLB41_RS08480 ENOG4105D9P serine threonine protein kinase HLB41_RS08485 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HLB41_RS08490 ENOG4105DJV ribulose-phosphate 3-epimerase HLB41_RS08495 ENOG4105FJ0 thiamine HLB41_RS08510 ENOG4108ZAA Alkaline-shock protein HLB41_RS08515 ENOG4105DP4 dak2 domain fusion protein ylov HLB41_RS08520 ENOG4105CB5 ATP-dependent DNA helicase recG HLB41_RS08535 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HLB41_RS08540 ENOG4105CHR reductase HLB41_RS08555 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HLB41_RS08560 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HLB41_RS08580 ENOG4105VB6 UPF0109 protein HLB41_RS08605 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HLB41_RS08620 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HLB41_RS08625 ENOG4105C79 DNA protecting protein DprA HLB41_RS08630 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HLB41_RS08640 ENOG4108HE4 integrase family HLB41_RS08670 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HLB41_RS08680 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HLB41_RS08685 ENOG4105KNE Phosphatidate cytidylyltransferase HLB41_RS08690 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HLB41_RS08695 ENOG4105DZP Membrane-associated zinc metalloprotease HLB41_RS08705 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HLB41_RS08715 ENOG4105CHV Transcription elongation factor NusA HLB41_RS08720 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HLB41_RS08725 ENOG4105VHM ribosomal protein HLB41_RS08735 ENOG4105W7A Protein of unknown function (DUF503) HLB41_RS08750 ENOG4105DTN riboflavin biosynthesis protein ribF HLB41_RS08770 ENOG4105C1V Peptidase, M16 HLB41_RS08780 ENOG4105E35 Dipicolinate synthase subunit A HLB41_RS08785 ENOG4108S0H Dipicolinic acid synthetase, b subunit HLB41_RS08790 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HLB41_RS08800 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HLB41_RS08810 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HLB41_RS08820 ENOG4105CNU cell division protein FtsK HLB41_RS08825 ENOG4105FDP GntR family transcriptional regulator HLB41_RS08830 ENOG4105DIH basic membrane HLB41_RS08835 ENOG4108JQ9 ABC transporter HLB41_RS08840 ENOG4105UIB (ABC) transporter HLB41_RS08860 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HLB41_RS08865 ENOG4105XZV Protein of unknown function (DUF3243) HLB41_RS08880 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HLB41_RS08885 ENOG4105CEV competence damage-inducible protein HLB41_RS08900 ENOG4105D48 metallophosphoesterase HLB41_RS08905 ENOG4105MCT stage V sporulation protein S HLB41_RS08910 ENOG4108IGT Dipeptidase HLB41_RS08915 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HLB41_RS08920 ENOG4105DQU oxidoreductase, subunit beta HLB41_RS08925 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HLB41_RS08955 ENOG410890F Dynamin family HLB41_RS08960 ENOG4105E0M Sulfatase HLB41_RS08970 ENOG4105F0V Cell wall hydrolase HLB41_RS08985 ENOG4105CS2 ec 3.2.1.21 HLB41_RS08990 ENOG4108S3Y transcriptional regulator HLB41_RS09010 ENOG41067MG lrgb family HLB41_RS09050 ENOG4105BZU Histidine kinase HLB41_RS09070 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HLB41_RS09075 ENOG4105D03 DNA-3-methyladenine glycosylase II HLB41_RS09080 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HLB41_RS09090 ENOG4105CGK Exodeoxyribonuclease III HLB41_RS09110 ENOG4105E0A ABC, transporter HLB41_RS09115 ENOG4105NIV Esterase HLB41_RS09125 ENOG4105VPX protein, conserved in bacteria HLB41_RS09130 ENOG410681U heavy metal transport detoxification protein HLB41_RS09135 ENOG4105C59 p-type ATPase HLB41_RS09145 ENOG4105K70 DNA-binding protein HLB41_RS09150 ENOG4105TMB Formate nitrite transporter HLB41_RS09165 ENOG4105C85 amino acid HLB41_RS09175 ENOG4108SJC Membrane HLB41_RS09180 ENOG4107QW4 alcohol dehydrogenase HLB41_RS09185 ENOG4105E98 transcriptional regulator DeoR family HLB41_RS09190 ENOG4105DE4 1-phosphofructokinase HLB41_RS09195 ENOG4105DM4 PTS System HLB41_RS09200 ENOG41069ER domain protein HLB41_RS09230 ENOG4106F1P AAA ATPase, central domain protein HLB41_RS09240 ENOG4105EN6 Membrane HLB41_RS09245 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HLB41_RS09250 ENOG4105CXI aluminum resistance protein HLB41_RS09255 ENOG4105KV4 Transcriptional regulator HLB41_RS09260 ENOG4105C5F glutamine synthetase HLB41_RS09300 ENOG41065S2 pneumococcal vaccine antigen HLB41_RS09305 ENOG4105DR5 peptidase HLB41_RS09310 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HLB41_RS09320 ENOG4105K7K Transcriptional regulator HLB41_RS09340 ENOG4108SVB resolvase HLB41_RS09350 ENOG4105CGH 5'-nucleotidase HLB41_RS09355 ENOG4108HW3 (ABC) transporter HLB41_RS09390 ENOG4105BZ1 (ABC) transporter HLB41_RS09395 ENOG4105BZ1 (ABC) transporter HLB41_RS09435 ENOG41067MG lrgb family HLB41_RS09445 ENOG4107RSM transcriptional regulator HLB41_RS09460 ENOG4105CJ1 ABC, transporter HLB41_RS09480 ENOG4107QIV Cytochrome c biogenesis protein HLB41_RS09535 ENOG4108903 Formimidoylglutamase HLB41_RS09540 ENOG4108VJ1 Transcriptional regulator (CarD family HLB41_RS09545 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HLB41_RS09550 ENOG4105CBC glutamate synthase HLB41_RS09560 ENOG4105CK7 Sodium proline symporter HLB41_RS09565 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HLB41_RS09570 ENOG4105FBA Phospholipase Carboxylesterase HLB41_RS09575 ENOG4105BZU Histidine kinase HLB41_RS09585 ENOG4107AYK membrAne HLB41_RS09620 ENOG4108IMY Transcriptional regulator HLB41_RS09625 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_RS09630 ENOG4107ZYJ bioY protein HLB41_RS09635 ENOG4107F3J Amp-dependent synthetase and ligase HLB41_RS09655 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HLB41_RS09665 ENOG4105E5W Transporter HLB41_RS09695 ENOG4108I0Z Aconitate hydratase HLB41_RS09700 ENOG4105BZ1 (ABC) transporter HLB41_RS09715 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HLB41_RS09720 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HLB41_RS09745 ENOG4105W8X HesB YadR YfhF-family protein HLB41_RS09755 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HLB41_RS09765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS09770 ENOG4105C0H protease HLB41_RS09775 ENOG4105K4P CoA-binding domain protein HLB41_RS09780 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLB41_RS09790 ENOG4105D9R oxidoreductase HLB41_RS09795 ENOG4108FPN Integrase HLB41_RS09800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_RS09805 ENOG4105ZX1 Transposase C HLB41_RS09825 ENOG4105CIG ABC transporter HLB41_RS09835 ENOG4105EMN RNA polymerase sigma factor HLB41_RS09845 ENOG4108KGH TRANSCRIPTIONal HLB41_RS09850 ENOG4107QJT sodium dicarboxylate symporter HLB41_RS09905 ENOG4105CUB amino acid HLB41_RS09925 ENOG4108JB9 formate dehydrogenase HLB41_RS09935 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HLB41_RS09940 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HLB41_RS09950 ENOG4105TMB Formate nitrite transporter HLB41_RS09955 ENOG4105D06 uba thif-type nad fad binding protein HLB41_RS09960 ENOG4105CVM Molybdenum cofactor synthesis domain protein HLB41_RS09965 ENOG4108ZAF Molybdopterin HLB41_RS09975 ENOG4105D1F ATP-binding protein HLB41_RS09990 ENOG410696E Membrane HLB41_RS09995 ENOG4105FR1 rard protein HLB41_RS10005 ENOG4105EWU Squalene--hopene cyclase HLB41_RS10015 ENOG4105CHR reductase HLB41_RS10020 ENOG4105C26 Dehydrogenase HLB41_RS10030 ENOG4108IA2 Sodium pantothenate symporter HLB41_RS10045 ENOG4106IQC argininosuccinate lyase HLB41_RS10055 ENOG410904N short-chain dehydrogenase reductase HLB41_RS10075 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HLB41_RS10095 ENOG4105VEQ Cold shock protein HLB41_RS10110 ENOG4108R1P HLB41_RS10120 ENOG41073R8 VanW family HLB41_RS10125 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HLB41_RS10135 ENOG4105KT7 mgtC SapB transporter HLB41_RS10175 ENOG4105CQB FAD linked oxidase domain protein HLB41_RS10210 ENOG4105CNG UPF0061 protein HLB41_RS10215 ENOG4105CIS alcohol dehydrogenase HLB41_RS10220 ENOG41082BM Transcriptional regulator, arsr family HLB41_RS10235 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HLB41_RS10260 ENOG4108A04 Beta-lactamase HLB41_RS10275 ENOG4105FFC UPF0187 protein HLB41_RS10300 ENOG4105DPN Oligoendopeptidase f HLB41_RS10305 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HLB41_RS10310 ENOG4105E5K Alpha-amylase HLB41_RS10340 ENOG4107V2S Transcriptional regulator HLB41_RS10350 ENOG4107CUJ Protein of unknown function (DUF2690) HLB41_RS10370 ENOG4105NX3 Membrane HLB41_RS10375 ENOG4105DQ5 transport system permease protein HLB41_RS10380 ENOG4105EHG Permease protein HLB41_RS10385 ENOG4108MES Periplasmic binding protein HLB41_RS10400 ENOG4107R3E Citrate transporter HLB41_RS10410 ENOG4108TN2 lmbE family HLB41_RS10470 ENOG4105H3G oxidoreductase HLB41_RS10495 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HLB41_RS10585 ENOG4108ZJ4 polysaccharide deacetylase HLB41_RS10600 ENOG4105KVH Transcriptional regulator HLB41_RS10605 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HLB41_RS10615 ENOG4105JAB phenazine biosynthesis protein, phzf family HLB41_RS10655 ENOG4105KVH Transcriptional regulator HLB41_RS10660 ENOG4105KVH Transcriptional regulator HLB41_RS10665 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HLB41_RS10670 ENOG4105D9R oxidoreductase HLB41_RS10675 ENOG4108TZY GntR Family Transcriptional Regulator HLB41_RS10680 ENOG4105KVH Transcriptional regulator HLB41_RS10710 ENOG4105C44 Serine transporter HLB41_RS10725 ENOG41090KN UPF0303 protein HLB41_RS10735 ENOG4105F27 Major Facilitator HLB41_RS10740 ENOG4105CV8 reductase HLB41_RS10755 ENOG4105KVH Transcriptional regulator HLB41_RS10760 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HLB41_RS10765 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HLB41_RS10770 ENOG4108UX3 '-nucleotidase HLB41_RS10775 ENOG4105C8Q Methyl-accepting chemotaxis HLB41_RS10790 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HLB41_RS10800 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HLB41_RS10805 ENOG4105CIS alcohol dehydrogenase HLB41_RS10815 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HLB41_RS10820 ENOG4105CV1 Transketolase (EC 2.2.1.1) HLB41_RS10835 ENOG4105C6Z Gluconate HLB41_RS10840 ENOG4105CMG Carbohydrate kinase HLB41_RS10845 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HLB41_RS10850 ENOG4105XDF Protein of unknown function (DUF1272) HLB41_RS10855 ENOG4105DDN Pentapeptide repeat-containing protein HLB41_RS10875 ENOG4105C37 (CBS) domain HLB41_RS11010 ENOG4108PSK reductase HLB41_RS11040 ENOG4108RCM Nitroreductase HLB41_RS11045 ENOG4105KVH Transcriptional regulator HLB41_RS11060 ENOG4105CUT histidyl-tRNA synthetase HLB41_RS11065 ENOG4108Z66 YbaK ebsC protein HLB41_RS11085 ENOG4108K8S endonuclease I HLB41_RS11145 ENOG4105DYS nad(p)h dehydrogenase (quinone) HLB41_RS11155 ENOG4105CRW Short chain fatty acid transporter HLB41_RS11170 ENOG41069JR HLB41_RS11175 ENOG4105DA5 (ABC) transporter HLB41_RS11190 ENOG4105CZM Major Facilitator HLB41_RS11195 ENOG4107MII Sugar-specific transcriptional regulator TrmB HLB41_RS11210 ENOG4108ISG Major Facilitator HLB41_RS11220 ENOG4105PNM synthesis protein HLB41_RS11225 ENOG4108VXD carboxy-peptidase HLB41_RS11255 ENOG4106YAD MORN repeat variant HLB41_RS11485 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HLB41_RS11510 ENOG410874W AraC family transcriptional regulator HLB41_RS11515 ENOG41082W1 Cupin 2, conserved barrel domain protein HLB41_RS11530 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HLB41_RS11535 ENOG4108JQ1 Dehydrogenase HLB41_RS11555 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HLB41_RS11580 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HLB41_RS11590 ENOG4105BZU Histidine kinase HLB41_RS11610 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HLB41_RS11630 ENOG4105JQZ Methyltransferase HLB41_RS11645 ENOG4105K6H D-cysteine desulfhydrase HLB41_RS11665 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLB41_RS11670 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HLB41_RS11715 ENOG41062D9 Histidine kinase HLB41_RS11720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS11840 ENOG4105D7V transposase HLB41_RS11855 ENOG4108YXU transcriptional regulator AsnC family HLB41_RS11860 ENOG4105CHR reductase HLB41_RS11865 ENOG4108IG5 Transcriptional regulator HLB41_RS11870 ENOG4107P5I polyketide synthase HLB41_RS11875 ENOG4105NAE bifunctional deaminase-reductase domain protein HLB41_RS11885 ENOG41085FC arsR family transcriptional regulator HLB41_RS11890 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HLB41_RS11895 ENOG4105D6J arsenicaL-resistance protein HLB41_RS11905 ENOG4105ETE Transcriptional regulator (LacI family HLB41_RS11910 ENOG4105NWF RbsD or FucU transport HLB41_RS11920 ENOG4105CNN ABC, transporter HLB41_RS11930 ENOG4107W7X Aldolase HLB41_RS11935 ENOG4105DET Rhamnulokinase HLB41_RS11955 ENOG4105Z7P Acetyltransferase (GNAT) family HLB41_RS11980 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HLB41_RS11995 ENOG4105E1K spore germination protein HLB41_RS12010 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HLB41_RS12015 ENOG4108TWJ NADH dehydrogenase subunit 5 HLB41_RS12040 ENOG4105CVP deoxyribo-dipyrimidine photolyase HLB41_RS12045 ENOG4108606 TspO/MBR family HLB41_RS12060 ENOG4105F6J Alpha beta hydrolase fold HLB41_RS12085 ENOG41090MY MarR family Transcriptional regulator HLB41_RS12110 ENOG4105CHJ isochorismatase hydrolase HLB41_RS12120 ENOG4105CGH 5'-nucleotidase HLB41_RS12135 ENOG4106A3M Cytochrome p-450 HLB41_RS12150 ENOG4105CSV Glutaminase HLB41_RS12170 ENOG4108Q8B Spore germination protein HLB41_RS12175 ENOG4108NHD germination protein HLB41_RS12185 ENOG4105CUB amino acid HLB41_RS12190 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HLB41_RS12195 ENOG4105YWU small acid-soluble spore protein HLB41_RS12205 ENOG41075H3 AraC family transcriptional regulator HLB41_RS12230 ENOG4105BZU Histidine kinase HLB41_RS12240 ENOG4108B31 Spore germination protein HLB41_RS12265 ENOG4108IMY Transcriptional regulator HLB41_RS12270 ENOG4105HDK L-asparaginase HLB41_RS12275 ENOG4108IJ0 Aspartate ammonia-lyase HLB41_RS12285 ENOG4105E2A Dehydrogenase HLB41_RS12310 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HLB41_RS12355 ENOG4105DWD nucleoside recognition domain protein HLB41_RS12370 ENOG4105FDT acyl-CoA dehydrogenase HLB41_RS12380 ENOG4108ZHR arsR family transcriptional regulator HLB41_RS12385 ENOG4106N3A copper homeostasis protein cutc HLB41_RS12395 ENOG4107258 Transcriptional regulator HLB41_RS12400 ENOG4105P4J Allophanate hydrolase, subunit 1 HLB41_RS12410 ENOG4105E7W lamb ycsf family protein HLB41_RS12425 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HLB41_RS12430 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HLB41_RS12435 ENOG4107RF6 penicillin-binding protein HLB41_RS12470 ENOG4105F1N DNA alkylation repair HLB41_RS12480 ENOG4108IQI permease HLB41_RS12490 ENOG410635A Membrane HLB41_RS12540 ENOG4108PCN EamA-like transporter family HLB41_RS12555 ENOG4108XET gCN5-related N-acetyltransferase HLB41_RS12560 ENOG4108DMH HTH_ARAC HLB41_RS12585 ENOG4105C19 ABC transporter HLB41_RS12590 ENOG4105CMR udp-glucose 4-epimerase HLB41_RS12600 ENOG4105WEC Molybdate metabolism regulator HLB41_RS12605 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HLB41_RS12620 ENOG4105FS7 Transcriptional regulator HLB41_RS12625 ENOG4108TVJ Nitroreductase HLB41_RS12645 ENOG4108IBT Inherit from COG: transposase HLB41_RS12735 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HLB41_RS12780 ENOG4105C8Y Acetylornithine aminotransferase HLB41_RS12810 ENOG4105CKK Glycosyl transferase, family 2 HLB41_RS12820 ENOG4105CSH Transporter HLB41_RS12835 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HLB41_RS12865 ENOG41068WN HLB41_RS12885 ENOG4105VMP Transcriptional regulator HLB41_RS12895 ENOG4105G6Z alkaline phosphatase HLB41_RS12900 ENOG4107RBI VanW family HLB41_RS12910 ENOG4105ECK Fatty Acid Desaturase HLB41_RS12925 ENOG4107258 Transcriptional regulator HLB41_RS12935 ENOG4105II7 pyrroline-5-carboxylate reductase HLB41_RS12970 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HLB41_RS12980 ENOG41061GT Aldolase HLB41_RS12990 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HLB41_RS12995 ENOG4105DKT Transcriptional regulator HLB41_RS13005 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HLB41_RS13010 ENOG4105F5R ABC transporter HLB41_RS13015 ENOG4105D4B ABC, transporter HLB41_RS13030 ENOG4105MKU Transcriptional regulator HLB41_RS13045 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HLB41_RS13055 ENOG41069ER domain protein HLB41_RS13075 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) HLB41_RS13095 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HLB41_RS13100 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HLB41_RS13105 ENOG4105CIH Imidazole acetol-phosphate transaminase HLB41_RS13125 ENOG41082JN Transcriptional regulator HLB41_RS13130 ENOG4105EYF MMPL domain protein HLB41_RS13135 ENOG4105C5H ABC transporter HLB41_RS13140 ENOG4105E0M Sulfatase HLB41_RS13145 ENOG4108ZCF integral membrane protein HLB41_RS13165 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HLB41_RS13170 ENOG4107VC0 DNA alkylation repair enzyme HLB41_RS13205 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HLB41_RS13240 ENOG4105D7T ABC transporter HLB41_RS13245 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HLB41_RS13250 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HLB41_RS13255 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HLB41_RS13265 ENOG4105C02 permease HLB41_RS13320 ENOG4105CHM Aminotransferase HLB41_RS13355 ENOG41089UC methyltransferase, type 11 HLB41_RS13370 ENOG4107BMA Transglycosylase associated protein HLB41_RS13395 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HLB41_RS13455 ENOG4105EPR degv family HLB41_RS13460 ENOG4105DPN Oligoendopeptidase f HLB41_RS13475 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HLB41_RS13500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS13505 ENOG4105BZU Histidine kinase HLB41_RS13510 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HLB41_RS13515 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HLB41_RS13550 ENOG4107SET aldo keto reductase HLB41_RS13565 ENOG4105DTQ mandelate racemase muconate lactonizing HLB41_RS13585 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HLB41_RS13595 ENOG4107T5V SNARE associated Golgi HLB41_RS13600 ENOG4105DCI Phosphohydrolase HLB41_RS13630 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HLB41_RS13640 ENOG41080HI glycine oxidase HLB41_RS13645 ENOG4105CTU Proline racemase HLB41_RS13650 ENOG4105CTU Proline racemase HLB41_RS13655 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HLB41_RS13660 ENOG4105C26 Dehydrogenase HLB41_RS13665 ENOG4105BZG amino acid carrier protein HLB41_RS13685 ENOG4108M1A Chitin-binding protein HLB41_RS13735 ENOG4105C9U ATP-dependent DNA helicase RecQ HLB41_RS13750 ENOG4105EEM helicase HLB41_RS13770 ENOG4108Z7F N-acetyltransferase HLB41_RS13795 ENOG4105MSB protein, conserved in bacteria HLB41_RS13800 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HLB41_RS13830 ENOG4108M1A Chitin-binding protein HLB41_RS13835 ENOG41082BV acetyltransferase HLB41_RS13840 ENOG4105E66 phosphoriboisomerase A HLB41_RS13855 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HLB41_RS13865 ENOG4108IJ7 Glycine betaine HLB41_RS13870 ENOG4107SQ8 Glycine betaine HLB41_RS13900 ENOG4105E1F short-chain dehydrogenase reductase HLB41_RS13915 ENOG4107RUY (E1 component), alpha subunit HLB41_RS13925 ENOG4107QKR Dehydrogenase HLB41_RS13945 ENOG41062ES Transcriptional regulator HLB41_RS13960 ENOG4105E98 transcriptional regulator DeoR family HLB41_RS13975 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HLB41_RS14000 ENOG4107Z3H Transcriptional regulator, TetR family HLB41_RS14005 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HLB41_RS14010 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HLB41_RS14040 ENOG4105MSI germination protein ypeb HLB41_RS14085 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HLB41_RS14095 ENOG4105FDR Membrane HLB41_RS14100 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HLB41_RS14105 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HLB41_RS14120 ENOG4105CGH 5'-nucleotidase HLB41_RS14130 ENOG4108IUM Glycogen debranching enzyme HLB41_RS14185 ENOG4107VFR oxidoreductase HLB41_RS14205 ENOG4105CJ1 ABC, transporter HLB41_RS14235 ENOG4105PKS Excinuclease abc c subunit domain protein HLB41_RS14245 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HLB41_RS14270 ENOG4105KWG Pfam:DUF1696 HLB41_RS14275 ENOG4108NRW Phospholipase, patatin family HLB41_RS14295 ENOG4108XI2 Domain of unknown function (DUF1963) HLB41_RS14300 ENOG4105KME endoribonuclease L-psp HLB41_RS14320 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HLB41_RS14325 ENOG4105E09 nadh pyrophosphatase HLB41_RS14340 ENOG4105FCD Major Facilitator HLB41_RS14385 ENOG4107Y9U Membrane HLB41_RS14410 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HLB41_RS14425 ENOG4107Y80 Major Facilitator superfamily HLB41_RS14475 ENOG4105CJN penicillin-binding protein HLB41_RS14480 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HLB41_RS14485 ENOG4105CB2 alcohol dehydrogenase HLB41_RS14550 ENOG4108HGU Histidine kinase HLB41_RS14565 ENOG4108JJB ABC transporter HLB41_RS14590 ENOG4107RF6 penicillin-binding protein HLB41_RS14595 ENOG4105BZU Histidine kinase HLB41_RS14600 ENOG410667J hydrolase HLB41_RS14700 ENOG4105ETU transcriptional activator (TenA HLB41_RS14705 ENOG4105CPF Cell wall formation (By similarity) HLB41_RS14715 ENOG4105D6E homoserine dehydrogenase HLB41_RS14780 ENOG4105DK7 lysyl-tRNA synthetase HLB41_RS14790 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HLB41_RS14800 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HLB41_RS14805 ENOG410900G Protein of unknown function (DUF421) HLB41_RS14815 ENOG4105CPQ Dehydrogenase HLB41_RS14890 ENOG4105KVH Transcriptional regulator HLB41_RS14895 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HLB41_RS14900 ENOG4107Y80 Major Facilitator superfamily HLB41_RS14910 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HLB41_RS14940 ENOG41075H3 AraC family transcriptional regulator HLB41_RS14960 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HLB41_RS14970 ENOG4105T9C HD domain HLB41_RS14985 ENOG4105DZ1 carboxypeptidase HLB41_RS15020 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HLB41_RS15025 ENOG4107QX3 carboxylase HLB41_RS15030 ENOG4105E39 Enoyl-CoA hydratase HLB41_RS15035 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HLB41_RS15040 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HLB41_RS15045 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HLB41_RS15050 ENOG4105C1G acyl-Coa dehydrogenase HLB41_RS15065 ENOG4107Z3H Transcriptional regulator, TetR family HLB41_RS15075 ENOG4105CJ1 ABC, transporter HLB41_RS15085 ENOG4105DIN metallophosphoesterase HLB41_RS15095 ENOG4107RF6 penicillin-binding protein HLB41_RS15100 ENOG4107RF6 penicillin-binding protein HLB41_RS15115 ENOG4107RVG penicillin-binding protein HLB41_RS15120 ENOG4105FQP Beta-lactamase HLB41_RS15180 ENOG4105W8Z 4'-phosphopantetheinyl transferase HLB41_RS15220 ENOG4105EQK -acetyltransferase HLB41_RS15225 ENOG4105EJ9 Membrane HLB41_RS15235 ENOG4105KRN Transcriptional regulator, abrb family HLB41_RS15260 ENOG4105CIN aminoacyl-histidine dipeptidase HLB41_RS15285 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HLB41_RS15290 ENOG41090HR transcriptional regulator HLB41_RS15295 ENOG4107RA9 decarboxylase HLB41_RS15310 ENOG41088CC tellurite resistance protein tehB HLB41_RS15330 ENOG4108RZE Tetr family transcriptional regulator HLB41_RS15340 ENOG4105C1J atp-dependent rna helicase HLB41_RS15350 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HLB41_RS15370 ENOG4108INS Transcriptional regulator HLB41_RS15380 ENOG4107STF Involved in phosphonate degradation (By similarity) HLB41_RS15385 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HLB41_RS15390 ENOG4105RD7 BadF BadG BcrA BcrD HLB41_RS15395 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HLB41_RS15415 ENOG4105F32 YngK protein HLB41_RS15445 ENOG4108KPJ rna polymerase sigma factor HLB41_RS15450 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HLB41_RS15480 ENOG4108JCI Transcriptional regulator HLB41_RS15505 ENOG4105BZ1 (ABC) transporter HLB41_RS15510 ENOG4105BZ1 (ABC) transporter HLB41_RS15525 ENOG4108RPX mosc domain containing protein HLB41_RS15530 ENOG4105DND Transcriptional regulator HLB41_RS15550 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HLB41_RS15555 ENOG4107V2S Transcriptional regulator HLB41_RS15585 ENOG41068WN HLB41_RS15595 ENOG4105C1Q protoporphyrinogen oxidase HLB41_RS15620 ENOG4105WCN acetyltransferase HLB41_RS15640 ENOG4105EYF MMPL domain protein HLB41_RS15650 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HLB41_RS15660 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) HLB41_RS15670 ENOG4108Y4K DNA-binding transcriptional activator HLB41_RS15680 ENOG41081I9 integral membrane protein HLB41_RS15695 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HLB41_RS15710 ENOG4105C19 ABC transporter HLB41_RS15715 ENOG4105C22 threonyL-tRNA synthetase HLB41_RS15720 ENOG4105FE9 pseudouridine synthase HLB41_RS15740 ENOG4105BZG amino acid carrier protein HLB41_RS15760 ENOG4105K70 DNA-binding protein HLB41_RS15775 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLB41_RS15780 ENOG4105WQT MbtH domain protein HLB41_RS15785 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_RS15790 ENOG4105WQI isochorismatase HLB41_RS15795 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HLB41_RS15800 ENOG4105E4F Isochorismate synthase HLB41_RS15805 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HLB41_RS15810 ENOG4105FCD Major Facilitator HLB41_RS15835 ENOG4105EYH Exonuclease HLB41_RS15840 ENOG4107RFY SbcCD D subunit HLB41_RS15855 ENOG4105E39 Enoyl-CoA hydratase HLB41_RS15860 ENOG4105N14 lysine exporter protein LysE YggA HLB41_RS15870 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HLB41_RS15875 ENOG4105C1G acyl-Coa dehydrogenase HLB41_RS15880 ENOG4105CR4 methylisocitrate lyase HLB41_RS15885 ENOG4105DXD 2-methylcitrate dehydratase HLB41_RS15895 ENOG4105W8X HesB YadR YfhF-family protein HLB41_RS15900 ENOG4105CZM Major Facilitator HLB41_RS15910 ENOG4105BZ4 penicillin-binding protein HLB41_RS15970 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HLB41_RS16015 ENOG4105KNA -acetyltransferase HLB41_RS16020 ENOG4105SZ6 Thioredoxin HLB41_RS16030 ENOG410841Q phosphoesterase PA-phosphatase related protein HLB41_RS16075 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HLB41_RS16080 ENOG4108JUB Transcriptional regulator HLB41_RS16085 ENOG4108TSC N-acetyltransferase HLB41_RS16090 ENOG4107S4Y M20 DapE family protein YgeY HLB41_RS16105 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HLB41_RS16130 ENOG4105C37 (CBS) domain HLB41_RS16165 ENOG4105E90 ABC transporter HLB41_RS16170 ENOG4108IJ8 ABC transporter HLB41_RS16200 ENOG4108YV3 Protein of unknown function (DUF2711) HLB41_RS16210 ENOG4105C6Z Gluconate HLB41_RS16215 ENOG4105CMG Carbohydrate kinase HLB41_RS16235 ENOG4107ZY0 Phenazine biosynthesis-like protein HLB41_RS16240 ENOG4106KNT transcriptional regulator HLB41_RS16245 ENOG4105WH1 Two component transcriptional regulator luxr family HLB41_RS16250 ENOG4105BZU Histidine kinase HLB41_RS16255 ENOG4105D8X mechanosensitive ion channel HLB41_RS16285 ENOG4105F0I Aminotransferase HLB41_RS16290 ENOG4108MES Periplasmic binding protein HLB41_RS16295 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HLB41_RS16310 ENOG4105CAQ asparagine synthetase HLB41_RS16315 ENOG4107Y70 Heat shock protein HLB41_RS16320 ENOG4108KF3 Electron transport protein SCO1 SenC HLB41_RS16330 ENOG4108RCR degv family HLB41_RS16340 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HLB41_RS16350 ENOG4108UT2 hemolysin iii HLB41_RS16355 ENOG4105E9Q Acyl-transferase HLB41_RS16360 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HLB41_RS16365 ENOG4107RVG penicillin-binding protein HLB41_RS16375 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HLB41_RS16380 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) HLB41_RS16395 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 HLB41_RS16420 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HLB41_RS16425 ENOG4105VMP Transcriptional regulator HLB41_RS16435 ENOG4105KD7 acetyltransferase HLB41_RS16455 ENOG4105CY2 Citrate transporter HLB41_RS16460 ENOG4107XGZ Hydrolase HLB41_RS16480 ENOG4105C8J )-transporter HLB41_RS16495 ENOG41062D9 Histidine kinase HLB41_RS16500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS16510 ENOG4105BZW Glycerate kinase HLB41_RS16515 ENOG4105C5S asparaginyl-tRNA synthetase HLB41_RS16530 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HLB41_RS16555 ENOG4105C75 arginyL-tRNA synthetase HLB41_RS16560 ENOG4107YX5 Pfam:DUF548 HLB41_RS16580 ENOG4108UUM single-stranded DNA-binding protein HLB41_RS16595 ENOG4105C5H ABC transporter HLB41_RS16640 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_RS16645 ENOG4108FPN Integrase HLB41_RS16670 ENOG4105MCT stage V sporulation protein S HLB41_RS16705 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HLB41_RS16710 ENOG4108IFG nitrite reductase, (NAD(P)H) HLB41_RS16715 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HLB41_RS16720 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HLB41_RS16725 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HLB41_RS16730 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HLB41_RS16760 ENOG4108ZAF Molybdopterin HLB41_RS16765 ENOG4105CVM Molybdenum cofactor synthesis domain protein HLB41_RS16770 ENOG4105D06 uba thif-type nad fad binding protein HLB41_RS16775 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HLB41_RS16780 ENOG4107V6Q Cyclic nucleotide-binding domain HLB41_RS16790 ENOG4105R3A Nitrate reductase HLB41_RS16795 ENOG4108IUE nitrate reductase beta subunit HLB41_RS16805 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HLB41_RS16820 ENOG4108V06 Glutathione peroxidase HLB41_RS16830 ENOG4105CNW domain protein HLB41_RS16840 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HLB41_RS16850 ENOG4105EMN RNA polymerase sigma factor HLB41_RS16855 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HLB41_RS16865 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HLB41_RS16890 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HLB41_RS16915 ENOG4105KBJ sporulation protein ytfj HLB41_RS17035 ENOG4108MGT Required for secretion of EsxA and EsxB HLB41_RS17070 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HLB41_RS17100 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLB41_RS17105 ENOG4108JYZ YitT family HLB41_RS17110 ENOG41087PP glycosyltransferase MGT family HLB41_RS17125 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HLB41_RS17140 ENOG4108X4Q Hydrolase HLB41_RS17150 ENOG4108ZRV stage ii sporulation protein p HLB41_RS17170 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HLB41_RS17180 ENOG4108VXD carboxy-peptidase HLB41_RS17190 ENOG4108ZRV stage ii sporulation protein p HLB41_RS17210 ENOG4108Z7R Chaperone CsaA HLB41_RS17230 ENOG4105C37 (CBS) domain HLB41_RS17235 ENOG4105SXS Protein of unknown function (DUF456) HLB41_RS17255 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HLB41_RS17265 ENOG4108S4H thioesterase Superfamily protein HLB41_RS17275 ENOG4108PJD permease HLB41_RS17290 ENOG4107T5V SNARE associated Golgi HLB41_RS17335 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HLB41_RS17345 ENOG4105K4T epimerase HLB41_RS17355 ENOG4105DSE periplasmic solute binding protein HLB41_RS17365 ENOG4105CKI cobalamin synthesis protein HLB41_RS17370 ENOG4107QM2 Aldo Keto reductase HLB41_RS17375 ENOG4105VMI -acetyltransferase HLB41_RS17390 ENOG4105DEN Luciferase family HLB41_RS17405 ENOG4108WPJ Ferritin-like domain HLB41_RS17410 ENOG4108K88 Membrane HLB41_RS17425 ENOG4105C8Q Methyl-accepting chemotaxis HLB41_RS17450 ENOG4105KAF membrAne HLB41_RS17455 ENOG4107XZQ multidrug resistance protein HLB41_RS17460 ENOG4105CPC Aldo Keto reductase HLB41_RS17465 ENOG4105YVS arsR family transcriptional regulator HLB41_RS17475 ENOG4105KRN Transcriptional regulator, abrb family HLB41_RS17525 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLB41_RS17530 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HLB41_RS17540 ENOG4105YWU small acid-soluble spore protein HLB41_RS17545 ENOG4108WBH protein TIM barrel HLB41_RS17560 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_RS17565 ENOG4105DUU IucA IucC family protein HLB41_RS17575 ENOG4105VRR gCN5-related N-acetyltransferase HLB41_RS17580 ENOG4105KT7 mgtC SapB transporter HLB41_RS17595 ENOG4105BZU Histidine kinase HLB41_RS17600 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_RS17610 ENOG4108KGH TRANSCRIPTIONal HLB41_RS17625 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HLB41_RS17635 ENOG4105D6E homoserine dehydrogenase HLB41_RS17660 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HLB41_RS17675 ENOG4105BZU Histidine kinase HLB41_RS17680 ENOG4105EFI regulatoR HLB41_RS17685 ENOG4105BZ1 (ABC) transporter HLB41_RS17740 ENOG4108UT6 Transferase hexapeptide repeat containing protein HLB41_RS17750 ENOG4105K64 Glycosyl transferase, family 2 HLB41_RS17760 ENOG4108JJ8 (ABC) transporter HLB41_RS17765 ENOG4108JJ9 ABC, transporter HLB41_RS17770 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HLB41_RS17775 ENOG4105C4M (Ubiquinol oxidase) subunit I HLB41_RS17785 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HLB41_RS17805 ENOG4105SKE transcriptional Regulator LysR family HLB41_RS17815 ENOG4105C32 Amino acid ABC transporter (Permease) HLB41_RS17820 ENOG4108IV0 ABC, transporter HLB41_RS17825 ENOG4105C0Z ABC transporter HLB41_RS17835 ENOG4105CKI cobalamin synthesis protein HLB41_RS17845 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HLB41_RS17850 ENOG4106F5Q Membrane HLB41_RS17855 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HLB41_RS17860 ENOG4108TVJ Nitroreductase HLB41_RS17865 ENOG4107ZXU DSBA oxidoreductase HLB41_RS17870 ENOG4108Z40 Transcriptional regulator HLB41_RS17875 ENOG4105GZI Transcriptional regulator HLB41_RS17880 ENOG4107RT3 EamA-like transporter family HLB41_RS17885 ENOG4105KTB nuclear export factor GLE1 HLB41_RS17890 ENOG4108T5E Copper resistance protein HLB41_RS17930 ENOG4107R16 Multicopper oxidase HLB41_RS17940 ENOG4107RAQ aminopeptidase HLB41_RS17960 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HLB41_RS17965 ENOG4105D9N nucleoside HLB41_RS17975 ENOG4107RHR regulatoR HLB41_RS17990 ENOG4105K8R UPF0145 protein HLB41_RS17995 ENOG410849A acetyltransferase, (GNAT) family HLB41_RS18040 ENOG4105C0X amino acid HLB41_RS18045 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HLB41_RS18060 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HLB41_RS18080 ENOG41068WN HLB41_RS18125 ENOG4105CYC Transferase HLB41_RS18130 ENOG4105DY9 regulatoR HLB41_RS18140 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HLB41_RS18145 ENOG4105C6X Major Facilitator HLB41_RS18170 ENOG4105C7B Threonine dehydratase HLB41_RS18175 ENOG4105C01 Dihydroxy-acid dehydratase HLB41_RS18180 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HLB41_RS18190 ENOG4105C7K acetolactate synthase HLB41_RS18195 ENOG4105CM2 brancheD-chain amino acid aminotransferase HLB41_RS18200 ENOG4105CHR reductase HLB41_RS18205 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HLB41_RS18225 ENOG4105H67 Protein of unknown function (DUF421) HLB41_RS18230 ENOG4105X5K response regulator receiver protein HLB41_RS18240 ENOG4105C8J )-transporter HLB41_RS18260 ENOG4105C6T cysteine synthase HLB41_RS18265 ENOG4105EU0 Major facilitator Superfamily HLB41_RS18270 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HLB41_RS18285 ENOG4105DXI Major Facilitator superfamily HLB41_RS18295 ENOG4105U3E Transcriptional regulator HLB41_RS18300 ENOG4105CSR polyphosphate kinase 2 HLB41_RS18315 ENOG4105E09 nadh pyrophosphatase HLB41_RS18320 ENOG4105FVX HLB41_RS18370 ENOG4105C6K Malic enzyme HLB41_RS18375 ENOG4108IJ0 Aspartate ammonia-lyase HLB41_RS18390 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HLB41_RS18410 ENOG4105CJ1 ABC, transporter HLB41_RS18445 ENOG4106BRA Membrane HLB41_RS18450 ENOG4105BZC d-serine deaminase HLB41_RS18465 ENOG4107JM4 Tetratricopeptide repeat HLB41_RS18480 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HLB41_RS18485 ENOG4107QIV Cytochrome c biogenesis protein HLB41_RS18505 ENOG4105EC3 peptidase S51, dipeptidase E HLB41_RS18510 ENOG4107QJQ Mate efflux family protein HLB41_RS18525 ENOG4105C9Q fumarate hydratase class II HLB41_RS18535 ENOG4105VUF Transcriptional regulator HLB41_RS18540 ENOG4105DFD Na H antiporter HLB41_RS18555 ENOG4108PJD permease HLB41_RS18560 ENOG4105CKI cobalamin synthesis protein HLB41_RS18570 ENOG4108UZ3 Transporter HLB41_RS18575 ENOG4105DRR Transcriptional regulator, GntR family HLB41_RS18585 ENOG4105PGM cation diffusion facilitator family transporter HLB41_RS18605 ENOG4105CAQ asparagine synthetase HLB41_RS18625 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HLB41_RS18635 ENOG4105CVJ phosphoglycerate mutase HLB41_RS18670 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HLB41_RS18675 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HLB41_RS18710 ENOG4105KAC Antibiotic biosynthesis monooxygenase HLB41_RS18745 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HLB41_RS18750 ENOG4105KTQ flagellar basal-body rod protein HLB41_RS18755 ENOG4105FZW flagellar biosynthesis regulator FlhF HLB41_RS18760 ENOG4105D7B Flagellar biosynthesis protein flha HLB41_RS18765 ENOG4105D00 flagellar biosynthetic protein flhB HLB41_RS18775 ENOG4105VS8 Flagellar biosynthetic protein fliq HLB41_RS18780 ENOG4105CN7 Flagellar biosynthetic protein FliP HLB41_RS18790 ENOG4105DD5 Flagellar motor switch protein HLB41_RS18795 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HLB41_RS18805 ENOG4105E4C Lytic transglycosylase catalytic HLB41_RS18810 ENOG4105I03 Flagellin HLB41_RS18815 ENOG4105I03 Flagellin HLB41_RS18825 ENOG4107R88 Chemotaxis protein (CheV) HLB41_RS18840 ENOG4105BZE flagellar hook protein, FlgE HLB41_RS18870 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HLB41_RS18875 ENOG4107U2N Flagellar M-ring protein HLB41_RS18885 ENOG4108ZC9 flagellar basal-body rod protein flgc HLB41_RS18890 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HLB41_RS18910 ENOG4105DTJ flagellar hook-associated protein HLB41_RS18915 ENOG4105E1Q flagellar hook-associated protein HLB41_RS18935 ENOG4105BZU Histidine kinase HLB41_RS18950 ENOG4105DD5 Flagellar motor switch protein HLB41_RS18955 ENOG4105CBS Chea signal transduction histidine kinase HLB41_RS18960 ENOG4107YTP response regulator receiver protein HLB41_RS18965 ENOG4105ER2 Ompa motb domain protein HLB41_RS18970 ENOG4107R0U MotA TolQ exbB proton channel HLB41_RS18980 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HLB41_RS19015 ENOG41080C8 DUF218 domain HLB41_RS19020 ENOG4105H67 Protein of unknown function (DUF421) HLB41_RS19030 ENOG4108Z5V transcriptional regulator, merr family HLB41_RS19035 ENOG4105CN5 Metallo-Beta-Lactamase HLB41_RS19040 ENOG4107RWR Sodium hydrogen exchanger HLB41_RS19050 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HLB41_RS19115 ENOG41081VK Ribonuclease HLB41_RS19135 ENOG4108SZE gCN5-related N-acetyltransferase HLB41_RS19150 ENOG4105CPK Glycosyl transferase (Group 1 HLB41_RS19180 ENOG4105HTX biosynthesis protein HLB41_RS19235 ENOG4105KHC sulfurtransferase HLB41_RS19245 ENOG4108W0I acetyltransferase HLB41_RS19255 ENOG410890F Dynamin family HLB41_RS19260 ENOG4105DHF Membrane HLB41_RS19265 ENOG4105C2W permease HLB41_RS19270 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HLB41_RS19275 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HLB41_RS19285 ENOG4105CTD carboxy-peptidase HLB41_RS19290 ENOG4105DVT helicase HLB41_RS19300 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HLB41_RS19315 ENOG4106F55 Protein of unknown function (DUF1273) HLB41_RS19355 ENOG4105BZ4 penicillin-binding protein HLB41_RS19365 ENOG4105CSM endonuclease III HLB41_RS19385 ENOG4105YAC HLB41_RS19390 ENOG4105DVT helicase HLB41_RS19405 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HLB41_RS19425 ENOG4105CPK Glycosyl transferase (Group 1 HLB41_RS19430 ENOG4105FJR Lmbe family HLB41_RS19440 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HLB41_RS19445 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HLB41_RS19450 ENOG4108JYZ YitT family HLB41_RS19485 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HLB41_RS19490 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HLB41_RS19505 ENOG41068YB TPR repeat-containing protein HLB41_RS19515 ENOG4105D49 3-dehydroquinate synthase HLB41_RS19520 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HLB41_RS19525 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HLB41_RS19530 ENOG4105EAH synthase HLB41_RS19540 ENOG4105XXQ heptaprenyl diphosphate synthase component I HLB41_RS19555 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HLB41_RS19585 ENOG41065D1 HLB41_RS19590 ENOG4105S2F HLB41_RS19605 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HLB41_RS19625 ENOG4107RB3 L-asparaginase HLB41_RS19630 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HLB41_RS19655 ENOG4108S6Z Negative regulator of genetic competence HLB41_RS19660 ENOG4108XDN Transcriptional regulator HLB41_RS19665 ENOG4107RGJ metallophosphoesterase HLB41_RS19675 ENOG4105I7S Abortive infection protein HLB41_RS19680 ENOG4105C9U ATP-dependent DNA helicase RecQ HLB41_RS19695 ENOG4108SAX Membrane HLB41_RS19710 ENOG4108WBT adenosyltransferase HLB41_RS19715 ENOG4105BZU Histidine kinase HLB41_RS19720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS19725 ENOG4105CRE cytochrome C HLB41_RS19730 ENOG4107TWT Cytochrome c biogenesis protein HLB41_RS19735 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HLB41_RS19740 ENOG4105FE9 pseudouridine synthase HLB41_RS19750 ENOG4108JIC nucleoside recognition domain protein HLB41_RS19755 ENOG4105DZ1 carboxypeptidase HLB41_RS19760 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HLB41_RS19785 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HLB41_RS19790 ENOG4105BZU Histidine kinase HLB41_RS19805 ENOG4105I3N Conserved Protein HLB41_RS19810 ENOG4105BZU Histidine kinase HLB41_RS19825 ENOG4105BZ4 penicillin-binding protein HLB41_RS19830 ENOG4107GRR phosphate transport regulator HLB41_RS19835 ENOG4105CJ3 phosphate transporter HLB41_RS19855 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HLB41_RS19880 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HLB41_RS19900 ENOG4105WH1 Two component transcriptional regulator luxr family HLB41_RS19905 ENOG4105ENE Histidine kinase HLB41_RS19925 ENOG4105DFD Na H antiporter HLB41_RS19950 ENOG4105C8J )-transporter HLB41_RS19955 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HLB41_RS19960 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HLB41_RS19965 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HLB41_RS19975 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HLB41_RS19980 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HLB41_RS19985 ENOG4107S4M Sulfate adenylate transferase HLB41_RS20000 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HLB41_RS20010 ENOG4105E0M Sulfatase HLB41_RS20015 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HLB41_RS20030 ENOG4107RVV histidinol phosphate phosphatase, hisj family HLB41_RS20035 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase HLB41_RS20045 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HLB41_RS20050 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HLB41_RS20055 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HLB41_RS20060 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HLB41_RS20065 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HLB41_RS20070 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HLB41_RS20085 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HLB41_RS20100 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HLB41_RS20105 ENOG4108ZP8 Acetolactate synthase small subunit HLB41_RS20110 ENOG4105C7K acetolactate synthase HLB41_RS20115 ENOG4105CM2 brancheD-chain amino acid aminotransferase HLB41_RS20135 ENOG4105KBJ sporulation protein ytfj HLB41_RS20140 ENOG41063Y9 HLB41_RS20145 ENOG4105CZN Potassium uptake protein HLB41_RS20175 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HLB41_RS20215 ENOG4105NQC Flavodoxin HLB41_RS20235 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HLB41_RS20245 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HLB41_RS20250 ENOG4105EA8 2-Nitropropane dioxygenase HLB41_RS20255 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HLB41_RS20295 ENOG4105CJ1 ABC, transporter HLB41_RS20305 ENOG4105CZV ABC transporter HLB41_RS20310 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HLB41_RS20315 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HLB41_RS20320 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HLB41_RS20325 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HLB41_RS20360 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HLB41_RS20365 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HLB41_RS20370 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HLB41_RS20375 ENOG4105BZU Histidine kinase HLB41_RS20380 ENOG4106DF1 HLB41_RS20390 ENOG41090MY MarR family Transcriptional regulator HLB41_RS20395 ENOG4105BZU Histidine kinase HLB41_RS20405 ENOG4105PXI polysaccharide deacetylase HLB41_RS20415 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HLB41_RS20425 ENOG4105E98 transcriptional regulator DeoR family HLB41_RS20445 ENOG4107RCV ABC transporter, permease HLB41_RS20450 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HLB41_RS20455 ENOG4105C4Y ABC transporter HLB41_RS20485 ENOG4105CHR reductase HLB41_RS20505 ENOG4108Z7G MaoC domain protein dehydratase HLB41_RS20510 ENOG410681C small acid-soluble spore protein HLB41_RS20515 ENOG4105CZN Potassium uptake protein HLB41_RS20520 ENOG4107TS3 membrane protein, TerC HLB41_RS20525 ENOG4108QTI )-transporter HLB41_RS20535 ENOG4106A3R peptidase HLB41_RS20555 ENOG4105JXH GntR family transcriptional regulator HLB41_RS20560 ENOG4105BZU Histidine kinase HLB41_RS20565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS20580 ENOG4105CQB FAD linked oxidase domain protein HLB41_RS20585 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HLB41_RS20590 ENOG4105K4I Scp-like extracellular HLB41_RS20600 ENOG4108YBP pseudouridine synthase HLB41_RS20610 ENOG4105EYF MMPL domain protein HLB41_RS20620 ENOG4108HM4 ABC transporter HLB41_RS20625 ENOG4105D38 putrescine abc transporter HLB41_RS20630 ENOG4105F38 ABC transporter, permease HLB41_RS20635 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HLB41_RS20640 ENOG4105C26 Dehydrogenase HLB41_RS20675 ENOG4105VFR signal peptidase HLB41_RS20680 ENOG4105DZ1 carboxypeptidase HLB41_RS20710 ENOG4105RHA ABC transporter, permease HLB41_RS20715 ENOG4108IUX (ABC) transporter HLB41_RS20730 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HLB41_RS20780 ENOG4105VZ8 Transcriptional regulator HLB41_RS20790 ENOG4105C7S Dehydrogenase HLB41_RS20855 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HLB41_RS20860 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HLB41_RS20865 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HLB41_RS20870 ENOG4105DK0 Indole-3-glycerol phosphate synthase HLB41_RS20875 ENOG4108I0Q anthranilate phosphoribosyltransferase HLB41_RS20880 ENOG4105DDQ anthranilate synthase HLB41_RS20890 ENOG4105CK7 Sodium proline symporter HLB41_RS20965 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HLB41_RS20975 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HLB41_RS20980 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HLB41_RS21000 ENOG4107TVC Glycosyl transferase, family 2 HLB41_RS21020 ENOG4105K64 Glycosyl transferase, family 2 HLB41_RS21040 ENOG4105EMS pseudouridine synthase HLB41_RS21045 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HLB41_RS21060 ENOG4105MIX Adenylate cyclase HLB41_RS21065 ENOG4108Z18 K06886 hemoglobin HLB41_RS21080 ENOG4105DPN Oligoendopeptidase f HLB41_RS21090 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HLB41_RS21100 ENOG4108ZCF integral membrane protein HLB41_RS21120 ENOG4105UQX Mate efflux family protein HLB41_RS21125 ENOG4108JQ7 (ABC) transporter HLB41_RS21135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLB41_RS21140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HLB41_RS21155 ENOG4105C31 Tryptophanyl-tRNA synthetase HLB41_RS21170 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HLB41_RS21175 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HLB41_RS21200 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HLB41_RS21210 ENOG4108KP7 hydrolase HLB41_RS21220 ENOG41073B9 HLB41_RS21225 ENOG4107AYK membrAne HLB41_RS21235 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HLB41_RS21295 ENOG4105QNR S1 RNA binding domain protein HLB41_RS21315 ENOG4105BZU Histidine kinase HLB41_RS21320 ENOG4105CH6 catalase HLB41_RS21325 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HLB41_RS21330 ENOG4105CAQ asparagine synthetase HLB41_RS21345 ENOG4105C8Y Acetylornithine aminotransferase HLB41_RS21355 ENOG4105ERH Fumarylacetoacetate hydrolase HLB41_RS21400 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HLB41_RS21460 ENOG4107QP3 malate synthase g HLB41_RS21470 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HLB41_RS21475 ENOG4105C8Q Methyl-accepting chemotaxis HLB41_RS21480 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HLB41_RS21500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_RS21510 ENOG41086D8 Transcriptional regulator HLB41_RS21515 ENOG4108AEY RNA polymerase sigma factor HLB41_RS21525 ENOG4107TVP HD domain protein HLB41_RS21530 ENOG4107RN3 metallophosphoesterase HLB41_RS21535 ENOG4105ENX hydrolase HLB41_RS21690 ENOG4108IJ6 ABC transporter HLB41_RS21695 ENOG4105ECW sulfate abc transporter HLB41_RS21700 ENOG4108I5D sulfate abc transporter HLB41_RS21705 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HLB41_RS21715 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_RS21725 ENOG4105DF9 Lipoate-protein, ligase HLB41_RS21730 ENOG4108RQ5 Beta-lactamase domain-containing protein HLB41_RS21735 ENOG4106AXD HLB41_RS21745 ENOG4108MK9 spermidine N(1)-acetyltransferase HLB41_RS21765 ENOG4105ECB domain protein HLB41_RS21780 ENOG4105NA0 Transcriptional regulator HLB41_RS21805 ENOG4105C1Q protoporphyrinogen oxidase HLB41_RS21810 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HLB41_RS21820 ENOG4105BZ4 penicillin-binding protein HLB41_RS21825 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HLB41_RS21830 ENOG4105CKV Membrane HLB41_RS21835 ENOG410905X membrane-flanked domain protein HLB41_RS21870 ENOG4105CKV Membrane HLB41_RS21875 ENOG410905X membrane-flanked domain protein HLB41_RS21910 ENOG4105K59 histidine triad (HIT) protein HLB41_RS21935 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HLB41_RS21945 ENOG4105EEM helicase HLB41_RS21960 ENOG4105DU6 RNA polymerase HLB41_RS21980 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HLB41_RS21995 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HLB41_RS22000 ENOG41067QW Transcriptional regulator HLB41_RS22005 ENOG4105F0F Oxalate decarboxylase HLB41_RS22030 ENOG4108MUZ hydrolase HLB41_RS22060 ENOG4106D4I domain protein HLB41_RS22065 ENOG4107VRP DNA repair exonuclease HLB41_RS22085 ENOG4107QHE Choloylglycine hydrolase HLB41_RS22130 ENOG4105BZU Histidine kinase HLB41_RS22135 ENOG4105BZU Histidine kinase HLB41_RS22140 ENOG4108MJI response regulator HLB41_RS22150 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_RS22160 ENOG4105WN5 stage II sporulation protein HLB41_RS22220 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HLB41_RS22255 ENOG41069ER domain protein HLB41_RS22295 ENOG4105CMT Dihydroxyacetone kinase HLB41_RS22305 ENOG4105CMT Dihydroxyacetone kinase HLB41_RS22320 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HLB41_RS22360 ENOG4105F6J Alpha beta hydrolase fold HLB41_RS22380 ENOG4105EKQ RNA-directed DNA polymerase HLB41_RS22385 ENOG4105D9U N-acetyltransferase HLB41_RS22400 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLB41_RS22425 ENOG4105CDU Replicative dna helicase HLB41_RS22460 ENOG4105DZR Type I site-specific deoxyribonuclease HLB41_RS22475 ENOG4105M6F mutator MutT protein HLB41_RS22485 ENOG4108MRH transcriptional regulatory protein HLB41_RS22495 ENOG4105CSH Transporter HLB41_RS22675 ENOG4108IBT Inherit from COG: transposase HLB41_RS22750 ENOG4108JQ7 (ABC) transporter HLB41_RS22755 ENOG4105C3U ABC transporter HLB41_RS22760 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLB41_RS22775 ENOG4105CIF Ornithine Cyclodeaminase HLB41_RS22780 ENOG4105CTU Proline racemase HLB41_RS22800 ENOG4105DER m42 family HLB41_RS22820 ENOG4105CGU Enoyl-CoA hydratase HLB41_RS22845 ENOG4105CHH sulfate transporter HLB41_RS22860 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_RS22865 ENOG4105D4P Coproporphyrinogen iii oxidase HLB41_RS22870 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HLB41_RS22885 ENOG4108VX5 3-methyladenine DNA glycosylase HLB41_RS22890 ENOG4107FQX Alpha-acetolactate decarboxylase HLB41_RS22900 ENOG4105WH1 Two component transcriptional regulator luxr family HLB41_RS22905 ENOG4105BZU Histidine kinase HLB41_RS22915 ENOG4108UH6 UPF0754 membrane protein HLB41_RS22925 ENOG410839P HLB41_RS22940 ENOG4105CDA abc transporter atp-binding protein HLB41_RS22945 ENOG4105DRP amino acid AbC transporter HLB41_RS22955 ENOG4105BZ1 (ABC) transporter HLB41_RS22960 ENOG4105BZ1 (ABC) transporter HLB41_RS22965 ENOG4105C26 Dehydrogenase HLB41_RS22975 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HLB41_RS22980 ENOG4105D5Q Arginine ornithine antiporter HLB41_RS22990 ENOG4105CH6 catalase HLB41_RS22995 ENOG4107RKG DJ-1/PfpI family HLB41_RS23010 ENOG4105E5W Transporter HLB41_RS23015 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HLB41_RS23020 ENOG4105NF4 modulator of drug activity HLB41_RS23060 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HLB41_RS23065 ENOG4105CH7 arginosuccinase HLB41_RS23070 ENOG4108YXU transcriptional regulator AsnC family HLB41_RS23105 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HLB41_RS23110 ENOG4106KNT transcriptional regulator HLB41_RS23120 ENOG4107RWR Sodium hydrogen exchanger HLB41_RS23125 ENOG4105CUB amino acid HLB41_RS23160 ENOG4107T5V SNARE associated Golgi HLB41_RS23195 ENOG4105WEF catalase HLB41_RS23225 ENOG4105C19 ABC transporter HLB41_RS23230 ENOG4107RBB ABC transporter, permease HLB41_RS23235 ENOG41069ER domain protein HLB41_RS23255 ENOG4105VZJ PTS System HLB41_RS23260 ENOG4105VCP PTS System HLB41_RS23265 ENOG4105EMD TRANSCRIPTIONal HLB41_RS23290 ENOG4108KGH TRANSCRIPTIONal HLB41_RS23300 ENOG41087NI Sulfite exporter TauE/SafE HLB41_RS23305 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HLB41_RS23310 ENOG41085GJ domain protein HLB41_RS23315 ENOG4105VFE sira family HLB41_RS23320 ENOG4105VFE sira family HLB41_RS23325 ENOG4107TPS domain protein HLB41_RS23330 ENOG4105VFE sira family HLB41_RS23335 ENOG4105XTG Pfam:DUF156 HLB41_RS23340 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HLB41_RS23355 ENOG4105J4Q Transcriptional regulator HLB41_RS23365 ENOG4105ED1 spovr family HLB41_RS23370 ENOG4107Y03 Nitroreductase HLB41_RS23390 ENOG4108B31 Spore germination protein HLB41_RS23410 ENOG4105K63 Thioredoxin HLB41_RS23425 ENOG4105C5Y PTS System HLB41_RS23445 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HLB41_RS23455 ENOG4105C7N Xanthine uracil vitamin C permease HLB41_RS23465 ENOG4105C2J ABC transporter HLB41_RS23470 ENOG4105CNN ABC, transporter HLB41_RS23485 ENOG4105C19 ABC transporter HLB41_RS23510 ENOG4108INS Transcriptional regulator HLB41_RS23525 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HLB41_RS23560 ENOG4105DWF phosphomethylpyrimidine kinase HLB41_RS23565 ENOG4105D06 uba thif-type nad fad binding protein HLB41_RS23580 ENOG41080HI glycine oxidase HLB41_RS23585 ENOG4108VEU Thiamine monophosphate synthase HLB41_RS23595 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HLB41_RS23605 ENOG4105ETU transcriptional activator (TenA HLB41_RS23625 ENOG41080XQ Signal transduction protein with cbs domains HLB41_RS23755 ENOG4105E2Z phosphate ABC transporter (Permease HLB41_RS23760 ENOG4105C8U phosphate abc transporter HLB41_RS23765 ENOG4105CVA phosphate HLB41_RS23770 ENOG4105CE1 Ferrous iron transport protein b HLB41_RS23775 ENOG4105CE1 Ferrous iron transport protein b HLB41_RS23780 ENOG4105CE1 Ferrous iron transport protein b HLB41_RS23785 ENOG4108NHD germination protein HLB41_RS23800 ENOG4105E1V na solute symporter HLB41_RS23805 ENOG4106CAD Protein of unknown function (DUF3311) HLB41_RS23825 ENOG4105E2S oxidase) subunit II HLB41_RS23830 ENOG4105BZ9 Cytochrome C oxidase, subunit I HLB41_RS23855 ENOG4105MA6 gCN5-related N-acetyltransferase HLB41_RS23870 ENOG4105C7N Xanthine uracil vitamin C permease HLB41_RS23875 ENOG4105C85 amino acid HLB41_RS23895 ENOG4105DUX Transporter HLB41_RS23910 ENOG4107D63 HLB41_RS23915 ENOG4105VZ8 Transcriptional regulator HLB41_RS23920 ENOG41069ER domain protein HLB41_RS23925 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HLB41_RS23930 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HLB41_RS23960 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) HLB41_RS23990 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HLB41_RS23995 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HLB41_RS24000 ENOG4105CNN ABC, transporter HLB41_RS24005 ENOG4105C2J ABC transporter HLB41_RS24010 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HLB41_RS24015 ENOG4108RVA ribokinase HLB41_RS24020 ENOG4105ETE Transcriptional regulator (LacI family HLB41_RS24025 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLB41_RS24030 ENOG41067TZ transcriptional regulator, MarR family HLB41_RS24035 ENOG4105CXY transporter HLB41_RS24045 ENOG41068KF Universal stress protein HLB41_RS24050 ENOG4105CHH sulfate transporter HLB41_RS24070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS24075 ENOG4105BZU Histidine kinase HLB41_RS24080 ENOG4105NAE bifunctional deaminase-reductase domain protein HLB41_RS24085 ENOG4105D29 Helix-turn-helix type 11 domain protein HLB41_RS24110 ENOG4108IQI permease HLB41_RS24115 ENOG4105DRP amino acid AbC transporter HLB41_RS24120 ENOG4105EAD ABC transporter HLB41_RS24125 ENOG4105CT1 (ABC) transporter HLB41_RS24130 ENOG4105CDA abc transporter atp-binding protein HLB41_RS24135 ENOG4105BZG amino acid carrier protein HLB41_RS24140 ENOG4105CRN Aminoglycoside phosphotransferase HLB41_RS24150 ENOG4105E1K spore germination protein HLB41_RS24165 ENOG4105CG3 alpha amylase, catalytic region HLB41_RS24170 ENOG4105C5Y PTS System HLB41_RS24175 ENOG4107414 GntR family transcriptional regulator HLB41_RS24180 ENOG4105D5Q Arginine ornithine antiporter HLB41_RS24185 ENOG4105BZU Histidine kinase HLB41_RS24195 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HLB41_RS24200 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HLB41_RS24205 ENOG4107T89 von Willebrand factor, type A HLB41_RS24215 ENOG4105EXW epimerase dehydratase HLB41_RS24220 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HLB41_RS24230 ENOG4105E0A ABC, transporter HLB41_RS24235 ENOG4108IHU transport system permease protein HLB41_RS24240 ENOG4105DQ5 transport system permease protein HLB41_RS24245 ENOG4108MES Periplasmic binding protein HLB41_RS24250 ENOG4105DUX Transporter HLB41_RS24265 ENOG4105DAA L-lactate HLB41_RS24270 ENOG4108IJ0 Aspartate ammonia-lyase HLB41_RS24275 ENOG4105C37 (CBS) domain HLB41_RS24280 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HLB41_RS24285 ENOG4105D9N nucleoside HLB41_RS24290 ENOG4108KGH TRANSCRIPTIONal HLB41_RS24295 ENOG41073R8 VanW family HLB41_RS24335 ENOG4105C59 p-type ATPase HLB41_RS24345 ENOG4105CUB amino acid HLB41_RS24365 ENOG4108JB9 formate dehydrogenase HLB41_RS24370 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HLB41_RS24380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS24385 ENOG4105BZU Histidine kinase HLB41_RS24395 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLB41_RS24400 ENOG4108UZ3 Transporter HLB41_RS24410 ENOG4105C6K Malic enzyme HLB41_RS24420 ENOG4108MRH transcriptional regulatory protein HLB41_RS24445 ENOG4105US7 Histidine kinase HLB41_RS24450 ENOG4108STX response regulator HLB41_RS24455 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HLB41_RS24460 ENOG4105BZ7 extracellular solute-binding protein family 1 HLB41_RS24465 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HLB41_RS24470 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HLB41_RS24475 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HLB41_RS24480 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HLB41_RS24505 ENOG4105D4T Citrate transporter HLB41_RS24510 ENOG4108V9W transcriptional regulatory protein HLB41_RS24515 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HLB41_RS24525 ENOG4105DZ6 Band 7 protein HLB41_RS24540 ENOG4105C94 Transporter HLB41_RS24555 ENOG4106AKX UPF0229 protein HLB41_RS24560 ENOG4105CYN Serine protein kinase HLB41_RS24565 ENOG4105BZU Histidine kinase HLB41_RS24570 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HLB41_RS24580 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HLB41_RS24590 ENOG4108R9S DSBA oxidoreductase HLB41_RS24595 ENOG4108JQC penicillin-binding protein 1A HLB41_RS24715 ENOG4105G5W regulator Fur family HLB41_RS24720 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HLB41_RS24740 ENOG4108IUW ABC transporter HLB41_RS24750 ENOG4105CBC glutamate synthase HLB41_RS24755 ENOG4107NBY Membrane HLB41_RS24760 ENOG4105BZ1 (ABC) transporter HLB41_RS24780 ENOG4106BXE HLB41_RS24785 ENOG4105CEN a g-specific adenine glycosylase HLB41_RS24790 ENOG41067AE Membrane-bound metal-dependent hydrolase HLB41_RS24820 ENOG4105ECP epimerase HLB41_RS24825 ENOG4105CI2 imidazolone-5-propionate hydrolase HLB41_RS24840 ENOG4108QBV Monogalactosyldiacylglycerol synthase HLB41_RS24845 ENOG4105F1A Pyruvate formate-lyase HLB41_RS24865 ENOG4105C3I Nad-dependent epimerase dehydratase HLB41_RS24870 ENOG4107QQG Dehydrogenase HLB41_RS24875 ENOG4105CKK Glycosyl transferase, family 2 HLB41_RS24890 ENOG4108A04 Beta-lactamase HLB41_RS24930 ENOG4108IQI permease HLB41_RS24940 ENOG4108JUB Transcriptional regulator HLB41_RS24950 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HLB41_RS24955 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HLB41_RS24990 ENOG4105UPD Calcium Proton HLB41_RS24995 ENOG410606W general stress protein HLB41_RS25010 ENOG4107ZTW SNARE associated Golgi HLB41_RS25020 ENOG4105C3F Signal peptidase i HLB41_RS25030 ENOG4108IPJ Membrane HLB41_RS25035 ENOG4105C59 p-type ATPase HLB41_RS25040 ENOG4107U9T Pfam:Ribonuclease_BN HLB41_RS25050 ENOG4105KJF protein tyrosine phosphatase HLB41_RS25070 ENOG4108TTB tellurium resistance protein HLB41_RS25075 ENOG4107TS3 membrane protein, TerC HLB41_RS25080 ENOG4106FN3 tellurium resistance protein HLB41_RS25085 ENOG4106FN3 tellurium resistance protein HLB41_RS25090 ENOG4108N0M stress protein HLB41_RS25105 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HLB41_RS25120 ENOG4105DEU major facilitator superfamily HLB41_RS25135 ENOG41062JF Transcriptional regulator HLB41_RS25175 ENOG4105D2X ABC transporter substrate-binding protein HLB41_RS25180 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HLB41_RS25200 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HLB41_RS25205 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HLB41_RS25210 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HLB41_RS25215 ENOG4105C9U ATP-dependent DNA helicase RecQ HLB41_RS25230 ENOG4105CI1 PTS System HLB41_RS25240 ENOG4105DNP FAD linked oxidase domain protein HLB41_RS25250 ENOG4108W63 CRP FNR family transcriptional regulator HLB41_RS25255 ENOG4105C5B carbamate kinase HLB41_RS25265 ENOG4105DBV ornithine carbamoyltransferase HLB41_RS25280 ENOG4105C8Q Methyl-accepting chemotaxis HLB41_RS25285 ENOG4105CDA abc transporter atp-binding protein HLB41_RS25290 ENOG4105EAB amino acid AbC transporter HLB41_RS25295 ENOG4105E5Q amino acid AbC transporter HLB41_RS25310 ENOG4105D2S major facilitator superfamily HLB41_RS25315 ENOG410756H nucleotidyltransferase HLB41_RS25335 ENOG4105BZU Histidine kinase HLB41_RS25350 ENOG4106UIA HLB41_RS25355 ENOG4106UIA HLB41_RS25375 ENOG4108V5C ABC transporter HLB41_RS25380 ENOG4105DQ5 transport system permease protein HLB41_RS25385 ENOG4105EHG Permease protein HLB41_RS25405 ENOG4105D3R alkyl hydroperoxide reductase HLB41_RS25425 ENOG4105DFD Na H antiporter HLB41_RS25435 ENOG4105DTQ mandelate racemase muconate lactonizing HLB41_RS25450 ENOG4108W15 Protein of unknown function (DUF1456) HLB41_RS25470 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HLB41_RS25475 ENOG4105D9N nucleoside HLB41_RS25505 ENOG4105KPY Small multidrug resistance protein HLB41_RS25510 ENOG4105C26 Dehydrogenase HLB41_RS25520 ENOG4108JPW Aminotransferase HLB41_RS25530 ENOG4105CBD Diacylglycerol kinase HLB41_RS25540 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HLB41_RS25550 ENOG4107I77 yiaA/B two helix domain HLB41_RS25555 ENOG410834F Transcriptional regulator HLB41_RS25575 ENOG4105D01 (LipO)protein HLB41_RS25580 ENOG4108UMI ABC transporter, permease HLB41_RS25585 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HLB41_RS25590 ENOG4108W2Y isochorismatase HLB41_RS25610 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HLB41_RS25615 ENOG4105C4R Atp-dependent dna helicase HLB41_RS25640 ENOG4105C12 Phosphoribosylglycinamide synthetase HLB41_RS25645 ENOG4105DC1 bifunctional purine biosynthesis protein purh HLB41_RS25650 ENOG4108V3E phosphoribosylglycinamide formyltransferase HLB41_RS25675 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HLB41_RS25685 ENOG4105C83 adenylosuccinate lyase HLB41_RS25690 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HLB41_RS25695 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HLB41_RS25720 ENOG4105SX7 Transporter HLB41_RS25740 ENOG4108SHN Glycosyl transferase, family 2 HLB41_RS25750 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HLB41_RS25760 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HLB41_RS25790 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_RS25835 ENOG4107ZXU DSBA oxidoreductase HLB41_RS25860 ENOG4105BZU Histidine kinase HLB41_RS25870 ENOG4105C7N Xanthine uracil vitamin C permease HLB41_RS25875 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HLB41_RS25890 ENOG4108TYN CAAX amino terminal protease family protein HLB41_RS25905 ENOG4105C5H ABC transporter HLB41_RS25910 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HLB41_RS25915 ENOG410801F ribosomal-protein-alanine acetyltransferase HLB41_RS25920 ENOG41072GX Peptidase M22 Glycoprotease HLB41_RS25925 ENOG4105K8N protein family UPF0079, ATPase HLB41_RS26030 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HLB41_RS26040 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HLB41_RS26045 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HLB41_RS26070 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HLB41_RS26075 ENOG4105CPF Cell wall formation (By similarity) HLB41_RS26080 ENOG4108SC4 )-transporter HLB41_RS26085 ENOG4105CUB amino acid HLB41_RS26095 ENOG4105ERH Fumarylacetoacetate hydrolase HLB41_RS26100 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HLB41_RS26130 ENOG410667J hydrolase HLB41_RS26135 ENOG4108JQ7 (ABC) transporter HLB41_RS26140 ENOG4105C3U ABC transporter HLB41_RS26145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLB41_RS26155 ENOG4105DEF Extracellular solute-binding protein, family 5 HLB41_RS26165 ENOG4105C5H ABC transporter HLB41_RS26185 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HLB41_RS26200 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HLB41_RS26220 ENOG4105F6E Acyl-transferase HLB41_RS26240 ENOG4105EGI Transcriptional regulator HLB41_RS26250 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HLB41_RS26255 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HLB41_RS26260 ENOG4105E0C molybdate abc transporter HLB41_RS26270 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HLB41_RS26285 ENOG4108J59 Extracellular solute-binding protein, family 5 HLB41_RS26290 ENOG4108J59 Extracellular solute-binding protein, family 5 HLB41_RS26320 ENOG4108JQ7 (ABC) transporter HLB41_RS26325 ENOG4105C3U ABC transporter HLB41_RS26330 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLB41_RS26335 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HLB41_RS26350 ENOG4105C2C drug resistance transporter, Bcr CflA HLB41_RS26365 ENOG4105IQ5 FAD linked oxidase domain protein HLB41_RS26375 ENOG4105CB2 alcohol dehydrogenase HLB41_RS26380 ENOG4105D01 (LipO)protein HLB41_RS26385 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HLB41_RS26390 ENOG4108UMI ABC transporter, permease HLB41_RS26395 ENOG4108PSK reductase HLB41_RS26470 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HLB41_RS26485 ENOG4107U5W ybbr family HLB41_RS26490 ENOG4105C8B TIGR00159 family HLB41_RS26570 ENOG4108NMV polysaccharide deacetylase HLB41_RS26585 ENOG4105D1F ATP-binding protein HLB41_RS26610 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HLB41_RS26615 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HLB41_RS26620 ENOG4108JJB ABC transporter HLB41_RS26625 ENOG4108JJB ABC transporter HLB41_RS26660 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HLB41_RS26670 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HLB41_RS26800 ENOG4105XPM ribosomal protein HLB41_RS26815 ENOG4107Y49 methyltransferase HLB41_RS26840 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HLB41_RS26855 ENOG4105QIV RNA polymerase HLB41_RS26860 ENOG4105M0M Tetracycline resistance protein HLB41_RS26865 ENOG4105C2N RNA methyltransferase TrmH family group 3 HLB41_RS26880 ENOG4105D7W serine acetyltransferase HLB41_RS26895 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HLB41_RS26900 ENOG4105CTP PilT protein domain protein HLB41_RS26905 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HLB41_RS26910 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HLB41_RS26925 ENOG4108Z0C Uvrb UvrC protein HLB41_RS27015 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HLB41_RS27025 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HLB41_RS27030 ENOG4105KRF dihydroneopterin aldolase HLB41_RS27035 ENOG4105EEI dihydropteroate synthase HLB41_RS27040 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HLB41_RS27045 ENOG4105DDQ anthranilate synthase HLB41_RS27050 ENOG4105CRQ synthase (Component I) HLB41_RS27055 ENOG4105C6T cysteine synthase HLB41_RS27070 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HLB41_RS27075 ENOG4108UGV hypoxanthine phosphoribosyltransferase HLB41_RS27080 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HLB41_RS27100 ENOG41060GV RNA binding s1 domain protein HLB41_RS27115 ENOG4105VYY sporulation protein yabp HLB41_RS27120 ENOG41082I2 s4 domain protein HLB41_RS27125 ENOG4108IY2 MazG family HLB41_RS27135 ENOG4108M14 stage v sporulation protein t HLB41_RS27140 ENOG4108JA2 transcriptioN-repair coupling factor HLB41_RS27150 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HLB41_RS27170 ENOG4105KME endoribonuclease L-psp HLB41_RS27175 ENOG4105DFT pur operon repressor HLB41_RS27190 ENOG4105C59 p-type ATPase HLB41_RS27195 ENOG4105VPX protein, conserved in bacteria HLB41_RS27200 ENOG4105DSE periplasmic solute binding protein HLB41_RS27270 ENOG4105K63 Thioredoxin HLB41_RS27280 ENOG4105EAB amino acid AbC transporter HLB41_RS27285 ENOG4105E5Q amino acid AbC transporter HLB41_RS27290 ENOG4105CDA abc transporter atp-binding protein HLB41_RS27300 ENOG4107R16 Multicopper oxidase HLB41_RS27305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS27310 ENOG4105BZU Histidine kinase HLB41_RS27320 ENOG4108ZRV stage ii sporulation protein p HLB41_RS27330 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) HLB41_RS27465 ENOG4105EKQ RNA-directed DNA polymerase HLB41_RS27485 ENOG4105EKQ RNA-directed DNA polymerase HLB41_RS27535 ENOG4108IMY Transcriptional regulator HLB41_RS27570 ENOG4107QYX exodeoxyribonuclease v alpha HLB41_RS27575 ENOG4105VTR Integrase HLB41_RS27610 ENOG4105W5Q DNA repair protein (RadC HLB41_RS27685 ENOG4108M1A Chitin-binding protein HLB41_RS27700 ENOG4107SDU Methyl-accepting chemotaxis HLB41_RS27720 ENOG4105K4H Nlp p60 protein HLB41_RS27760 ENOG41080HT Transcriptional regulator, arsr family HLB41_RS27785 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HLB41_RS27885 ENOG4105EKQ RNA-directed DNA polymerase HLB41_RS27905 ENOG4105EKQ RNA-directed DNA polymerase HLB41_RS27965 ENOG4105EKQ RNA-directed DNA polymerase HLB41_RS28025 ENOG4105EKQ RNA-directed DNA polymerase HLB41_RS28030 ENOG4105CNU cell division protein FtsK HLB41_RS28060 ENOG4105D7V transposase HLB41_RS28220 ENOG41085FC arsR family transcriptional regulator HLB41_RS28225 ENOG4105CAY ferredoxin--nadp reductase HLB41_RS28235 ENOG4105H3G oxidoreductase HLB41_RS28245 ENOG4105CN5 Metallo-Beta-Lactamase HLB41_RS28250 ENOG4107YZX Universal stress protein HLB41_RS28255 ENOG4105CHH sulfate transporter HLB41_RS28275 ENOG4105CHH sulfate transporter HLB41_RS28290 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HLB41_RS28310 ENOG41082YX Transcriptional regulator, arsr family HLB41_RS28315 ENOG4105D6J arsenicaL-resistance protein HLB41_RS28335 ENOG4105C3M thioredoxin reductase HLB41_RS28405 ENOG4105EKQ RNA-directed DNA polymerase HLB41_RS28485 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HLB41_RS28500 ENOG4105E2A Dehydrogenase HLB41_RS28505 ENOG4105KVH Transcriptional regulator HLB41_RS28515 ENOG4108QBQ Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione (By similarity) HLB41_RS28535 ENOG4105C4W S-formylglutathione hydrolase HLB41_RS28540 ENOG4105D9M gamma-glutamylcysteine synthetase HLB41_RS28545 ENOG4108B31 Spore germination protein HLB41_RS28580 ENOG4105C4W S-formylglutathione hydrolase HLB41_RS28595 ENOG4105D9M gamma-glutamylcysteine synthetase HLB41_RS28600 ENOG4105D9M gamma-glutamylcysteine synthetase HLB41_RS28625 ENOG41067QW Transcriptional regulator HLB41_RS28635 ENOG4105DHF Membrane HLB41_RS28705 ENOG4105KRN Transcriptional regulator, abrb family HLB41_RS28715 ENOG4108FPN Integrase HLB41_RS28720 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_RS28725 ENOG4105ZX1 Transposase C HLB41_RS28735 ENOG4108FPN Integrase HLB41_RS28740 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_RS28765 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HLB41_RS28795 ENOG4108J59 Extracellular solute-binding protein, family 5 HLB41_RS28810 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_RS28890 ENOG4105W1Y Transcriptional regulator HLB41_RS28920 ENOG4108IBT Inherit from COG: transposase HLB41_RS28940 ENOG4105KVH Transcriptional regulator HLB41_RS28950 ENOG4105C4W S-formylglutathione hydrolase HLB41_RS28960 ENOG4105D9M gamma-glutamylcysteine synthetase HLB41_RS28980 ENOG4108NHD germination protein HLB41_RS28990 ENOG4108W2Y isochorismatase HLB41_RS29000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_RS29050 ENOG4105D6J arsenicaL-resistance protein HLB41_RS29055 ENOG41082YX Transcriptional regulator, arsr family HLB41_RS29075 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HLB41_RS29085 ENOG41067QW Transcriptional regulator HLB41_RS29090 ENOG4105CJ3 phosphate transporter HLB41_RS29095 ENOG41085FC arsR family transcriptional regulator HLB41_RS29110 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes