locus-tag	class	description
HLB41_RS00010	COG4466	Protein conserved in bacteria
HLB41_RS00030	COG0084	hydrolase, TatD family'
HLB41_RS00040	COG2002	toxin-antitoxin pair type II binding
HLB41_RS00045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HLB41_RS00055	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HLB41_RS00065	COG1774	PSP1 C-terminal conserved region
HLB41_RS00070	COG0470	DNA polymerase III
HLB41_RS00080	COG1982	Orn Lys Arg decarboxylase major
HLB41_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLB41_RS00145	COG0590	tRNA wobble adenosine to inosine editing
HLB41_RS00150	COG1335	isochorismatase
HLB41_RS00155	COG1428	Deoxynucleoside kinase
HLB41_RS00160	COG1428	Deoxynucleoside kinase
HLB41_RS00190	COG1686	Belongs to the peptidase S11 family
HLB41_RS00195	COG0517	IMP dehydrogenase activity
HLB41_RS00195	COG0516	GMP reductase activity
HLB41_RS00230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLB41_RS00235	COG0187	DNA topoisomerase II activity
HLB41_RS00245	COG2501	S4 domain
HLB41_RS00250	COG0592	DNA-directed DNA polymerase activity
HLB41_RS00260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HLB41_RS00275	COG1847	R3H domain protein
HLB41_RS00300	COG1192	Involved in chromosome partitioning
HLB41_RS00305	COG1475	DNA binding
HLB41_RS00315	COG0668	transmembrane transport
HLB41_RS00320	COG4481	Protein conserved in bacteria
HLB41_RS00325	COG0012	GTP binding
HLB41_RS00345	COG4241	membrane
HLB41_RS00350	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HLB41_RS00360	COG0305	Participates in initiation and elongation during chromosome replication
HLB41_RS00390	COG0745	RESPONSE REGULATOR receiver
HLB41_RS00395	COG5002	protein histidine kinase activity
HLB41_RS00405	COG4853	Protein conserved in bacteria
HLB41_RS00410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HLB41_RS00415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB41_RS00430	COG5002	protein histidine kinase activity
HLB41_RS00440	COG1164	Oligoendopeptidase f
HLB41_RS00460	COG1272	protein, Hemolysin III
HLB41_RS00465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLB41_RS00485	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HLB41_RS00490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB41_RS00495	COG2814	Major facilitator Superfamily
HLB41_RS00500	COG3275	phosphorelay sensor kinase activity
HLB41_RS00520	COG0628	permease
HLB41_RS00525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLB41_RS00525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLB41_RS00530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB41_RS00535	COG1309	transcriptional regulator
HLB41_RS00540	COG0488	(ABC) transporter
HLB41_RS00545	COG0463	Glycosyl transferase, family 2
HLB41_RS00550	COG4485	Bacterial membrane protein, YfhO
HLB41_RS00560	COG1216	Glycosyl transferase, family 2
HLB41_RS00570	COG1216	Glycosyl transferase, family 2
HLB41_RS00575	COG1607	acyl-coa hydrolase
HLB41_RS00585	COG0840	transmembrane signaling receptor activity
HLB41_RS00600	COG0438	transferase activity, transferring glycosyl groups
HLB41_RS00610	COG0477	Major facilitator Superfamily
HLB41_RS00615	COG3279	Response regulator of the LytR AlgR family
HLB41_RS00620	COG1966	Carbon starvation protein
HLB41_RS00625	COG2879	small protein
HLB41_RS00630	COG3706	GGDEF domain
HLB41_RS00635	COG0351	phosphomethylpyrimidine kinase
HLB41_RS00640	COG2203	Gaf domain
HLB41_RS00640	COG4585	Histidine kinase
HLB41_RS00645	COG2197	response regulator
HLB41_RS00655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB41_RS00660	COG1011	Hydrolase
HLB41_RS00670	COG2873	o-acetylhomoserine
HLB41_RS00680	COG0460	homoserine dehydrogenase
HLB41_RS00690	COG1609	Transcriptional regulator
HLB41_RS00695	COG2755	lipolytic protein G-D-S-L family
HLB41_RS00700	COG1131	(ABC) transporter
HLB41_RS00705	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HLB41_RS00715	COG2814	Major facilitator Superfamily
HLB41_RS00720	COG0561	phosphatase activity
HLB41_RS00725	COG2233	PERMEase
HLB41_RS00730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLB41_RS00740	COG2363	Small membrane protein
HLB41_RS00750	COG3773	Cell wall hydrolase
HLB41_RS00765	COG0280	phosphate acetyltransferase
HLB41_RS00785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_RS00790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_RS00795	COG1120	ATPase activity
HLB41_RS00800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_RS00805	COG1078	dGTPase activity
HLB41_RS00815	COG1994	Peptidase M50
HLB41_RS00825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB41_RS00830	COG0584	glycerophosphoryl diester phosphodiesterase
HLB41_RS00835	COG0789	Transcriptional regulator
HLB41_RS00840	COG2814	Major facilitator Superfamily
HLB41_RS00865	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLB41_RS00870	COG4506	Protein conserved in bacteria
HLB41_RS00880	COG1595	DNA-templated transcription, initiation
HLB41_RS00900	COG2234	aminopeptidase activity
HLB41_RS00910	COG0024	Methionine aminopeptidase
HLB41_RS00915	COG1131	(ABC) transporter
HLB41_RS00920	COG0842	Transport permease protein
HLB41_RS00925	COG4585	Histidine kinase
HLB41_RS00930	COG2197	response regulator
HLB41_RS00935	COG3227	Zinc metalloprotease (Elastase)
HLB41_RS00950	COG3300	MHYT domain
HLB41_RS00950	COG5001	Diguanylate cyclase
HLB41_RS00960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLB41_RS00965	COG0247	lactate metabolic process
HLB41_RS00965	COG2181	nitrate reductase activity
HLB41_RS00970	COG0183	Belongs to the thiolase family
HLB41_RS00975	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB41_RS00980	COG1960	acyl-CoA dehydrogenase activity
HLB41_RS00985	COG1960	acyl-CoA dehydrogenase activity
HLB41_RS01005	COG4821	SIS domain
HLB41_RS01025	COG1494	fructose-1,6-bisphosphatase
HLB41_RS01030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HLB41_RS01065	COG0009	L-threonylcarbamoyladenylate synthase
HLB41_RS01080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLB41_RS01085	COG2259	Doxx family
HLB41_RS01100	COG0698	ribose 5-phosphate isomerase
HLB41_RS01135	COG0356	it plays a direct role in the translocation of protons across the membrane
HLB41_RS01185	COG5001	Diguanylate cyclase
HLB41_RS01185	COG3300	MHYT domain
HLB41_RS01200	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB41_RS01220	COG0839	Belongs to the complex I subunit 6 family
HLB41_RS01230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLB41_RS01235	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB41_RS01240	COG1007	ATP synthesis coupled electron transport
HLB41_RS01245	COG4836	Membrane
HLB41_RS01260	COG2385	sporulation resulting in formation of a cellular spore
HLB41_RS01265	COG4555	ABC transporter
HLB41_RS01280	COG0739	heme binding
HLB41_RS01290	COG1609	Transcriptional regulator
HLB41_RS01305	COG0489	protein tyrosine kinase activity
HLB41_RS01310	COG3944	biosynthesis protein
HLB41_RS01315	COG0489	protein tyrosine kinase activity
HLB41_RS01320	COG4464	protein tyrosine phosphatase activity
HLB41_RS01325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLB41_RS01330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLB41_RS01335	COG1215	transferase activity, transferring glycosyl groups
HLB41_RS01350	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HLB41_RS01355	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HLB41_RS01365	COG0438	transferase activity, transferring glycosyl groups
HLB41_RS01370	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HLB41_RS01385	COG1091	dTDP-4-dehydrorhamnose reductase activity
HLB41_RS01400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLB41_RS01405	COG0745	RESPONSE REGULATOR receiver
HLB41_RS01410	COG5002	protein histidine kinase activity
HLB41_RS01435	COG1136	(ABC) transporter
HLB41_RS01440	COG0577	efflux transmembrane transporter activity
HLB41_RS01480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLB41_RS01485	COG4715	Zinc finger, swim domain protein
HLB41_RS01510	COG1388	LysM domain
HLB41_RS01510	COG3584	3D domain protein
HLB41_RS01515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB41_RS01520	COG1215	transferase activity, transferring glycosyl groups
HLB41_RS01530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_RS01535	COG0791	NLP P60 protein
HLB41_RS01535	COG1388	LysM domain
HLB41_RS01545	COG1368	sulfuric ester hydrolase activity
HLB41_RS01555	COG2389	metal-binding protein
HLB41_RS01565	COG1620	l-lactate permease
HLB41_RS01575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLB41_RS01580	COG1294	oxidase, subunit
HLB41_RS01585	COG1271	oxidase subunit
HLB41_RS01595	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HLB41_RS01600	COG0583	DNA-binding transcription factor activity
HLB41_RS01605	COG1511	domain protein
HLB41_RS01635	COG1301	dicarboxylic acid transport
HLB41_RS01640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLB41_RS01650	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLB41_RS01670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLB41_RS01675	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLB41_RS01680	COG1486	melibiose metabolic process
HLB41_RS01700	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HLB41_RS01700	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HLB41_RS01710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLB41_RS01715	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HLB41_RS01720	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLB41_RS01725	COG1316	TRANSCRIPTIONal
HLB41_RS01730	COG1739	Uncharacterized protein family UPF0029
HLB41_RS01735	COG1307	EDD domain protein, DegV family
HLB41_RS01740	COG1733	regulation of RNA biosynthetic process
HLB41_RS01745	COG0791	NLP P60 protein
HLB41_RS01750	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HLB41_RS01755	COG1040	competence protein
HLB41_RS01760	COG1278	Cold shock
HLB41_RS01765	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLB41_RS01795	COG1131	(ABC) transporter
HLB41_RS01820	COG2884	Cell division ATP-binding protein ftsE
HLB41_RS01825	COG2177	Part of the ABC transporter FtsEX involved in
HLB41_RS01830	COG3409	Peptidoglycan-binding domain 1 protein
HLB41_RS01830	COG0793	Belongs to the peptidase S41A family
HLB41_RS01835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB41_RS01840	COG1132	(ABC) transporter
HLB41_RS01855	COG0655	NAD(P)H dehydrogenase (quinone) activity
HLB41_RS01865	COG0583	DNA-binding transcription factor activity
HLB41_RS01885	COG0789	Transcriptional regulator
HLB41_RS01900	COG0556	nucleotide-excision repair
HLB41_RS01905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLB41_RS01910	COG1950	PFAM Membrane protein of
HLB41_RS01930	COG0110	maltose O-acetyltransferase activity
HLB41_RS01935	COG0457	Tetratricopeptide repeat
HLB41_RS01940	COG0492	ferredoxin-NADP+ reductase activity
HLB41_RS01950	COG1051	belongs to the nudix hydrolase family
HLB41_RS01960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HLB41_RS01970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB41_RS01980	COG2323	membrane
HLB41_RS01995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLB41_RS02025	COG4585	Histidine kinase
HLB41_RS02030	COG4152	abc transporter atp-binding protein
HLB41_RS02035	COG1668	transmembrane transport
HLB41_RS02045	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HLB41_RS02060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLB41_RS02095	COG1346	cytolysis
HLB41_RS02100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLB41_RS02105	COG1647	Serine aminopeptidase, S33
HLB41_RS02110	COG0557	exoribonuclease II activity
HLB41_RS02185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS02190	COG0488	(ABC) transporter
HLB41_RS02240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLB41_RS02245	COG1252	NADH dehydrogenase
HLB41_RS02255	COG1733	regulation of RNA biosynthetic process
HLB41_RS02260	COG2814	Major facilitator Superfamily
HLB41_RS02265	COG0656	L-ascorbic acid biosynthetic process
HLB41_RS02280	COG2910	NAD(P)H-binding
HLB41_RS02285	COG1115	amino acid carrier protein
HLB41_RS02290	COG1115	amino acid carrier protein
HLB41_RS02295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_RS02300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_RS02310	COG1528	Iron-storage protein
HLB41_RS02320	COG1611	Belongs to the LOG family
HLB41_RS02335	COG0783	Belongs to the Dps family
HLB41_RS02340	COG1115	amino acid carrier protein
HLB41_RS02345	COG0490	domain, Protein
HLB41_RS02350	COG0475	glutathione-regulated potassium exporter activity
HLB41_RS02355	COG0586	Pfam SNARE associated Golgi protein
HLB41_RS02370	COG1741	Belongs to the pirin family
HLB41_RS02375	COG3227	Zinc metalloprotease (Elastase)
HLB41_RS02380	COG2151	metal-sulfur cluster biosynthetic enzyme
HLB41_RS02385	COG0840	transmembrane signaling receptor activity
HLB41_RS02425	COG5002	protein histidine kinase activity
HLB41_RS02430	COG0745	RESPONSE REGULATOR receiver
HLB41_RS02435	COG1376	ErfK ybiS ycfS ynhG family protein
HLB41_RS02445	COG0586	Pfam SNARE associated Golgi protein
HLB41_RS02485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_RS02515	COG0531	amino acid
HLB41_RS02525	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HLB41_RS02530	COG2814	Major facilitator Superfamily
HLB41_RS02545	COG0840	transmembrane signaling receptor activity
HLB41_RS02550	COG0011	TIGRFAM Protein of
HLB41_RS02565	COG1686	Belongs to the peptidase S11 family
HLB41_RS02575	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB41_RS02575	COG1024	Enoyl-CoA hydratase
HLB41_RS02580	COG0183	Belongs to the thiolase family
HLB41_RS02585	COG1960	acyl-CoA dehydrogenase activity
HLB41_RS02590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_RS02595	COG1309	transcriptional regulator
HLB41_RS02635	COG1393	Belongs to the ArsC family
HLB41_RS02645	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HLB41_RS02650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_RS02665	COG2011	ABC-type metal ion transport system permease component
HLB41_RS02670	COG1464	Belongs to the NlpA lipoprotein family
HLB41_RS02675	COG1464	Belongs to the NlpA lipoprotein family
HLB41_RS02680	COG0396	ATPase activity
HLB41_RS02685	COG0719	Fe-S assembly protein
HLB41_RS02690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLB41_RS02695	COG0822	iron-sulfur transferase activity
HLB41_RS02700	COG0719	Fe-S assembly protein
HLB41_RS02705	COG0737	Belongs to the 5'-nucleotidase family
HLB41_RS02710	COG3377	Domain of unknown function (DUF1805)
HLB41_RS02720	COG0739	heme binding
HLB41_RS02745	COG4377	Putative membrane peptidase family (DUF2324)
HLB41_RS02750	COG0789	Transcriptional regulator
HLB41_RS02760	COG4470	Protein conserved in bacteria
HLB41_RS02780	COG1494	fructose-1,6-bisphosphatase
HLB41_RS02785	COG2445	Protein of unknown function DUF86
HLB41_RS02795	COG0647	UMP catabolic process
HLB41_RS02805	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLB41_RS02815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLB41_RS02820	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLB41_RS02830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HLB41_RS02835	COG4837	Protein of unknown function (DUF1462)
HLB41_RS02875	COG2824	Alkylphosphonate utilization operon protein PhnA
HLB41_RS02880	COG0390	transport system, permease component
HLB41_RS02895	COG1252	NADH dehydrogenase
HLB41_RS02910	COG0316	Belongs to the HesB IscA family
HLB41_RS02930	COG1683	Conserved Protein
HLB41_RS02945	COG3708	Transcriptional regulator
HLB41_RS02960	COG1252	NADH dehydrogenase
HLB41_RS02975	COG3584	3D domain protein
HLB41_RS02985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HLB41_RS02990	COG2076	Multidrug Resistance protein
HLB41_RS03010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLB41_RS03015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLB41_RS03020	COG1268	BioY protein
HLB41_RS03030	COG2050	protein possibly involved in aromatic compounds catabolism
HLB41_RS03050	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLB41_RS03055	COG5018	Exonuclease
HLB41_RS03075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HLB41_RS03085	COG2267	carboxylic ester hydrolase activity
HLB41_RS03090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLB41_RS03095	COG1522	sequence-specific DNA binding
HLB41_RS03100	COG0436	Aminotransferase
HLB41_RS03105	COG1098	S1 RNA binding domain
HLB41_RS03110	COG2155	Conserved Protein
HLB41_RS03125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLB41_RS03130	COG1285	pathogenesis
HLB41_RS03165	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLB41_RS03265	COG1404	Belongs to the peptidase S8 family
HLB41_RS03285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLB41_RS03295	COG0058	SHG alpha-glucan phosphorylase activity
HLB41_RS03320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLB41_RS03325	COG1575	Belongs to the MenA family. Type 1 subfamily
HLB41_RS03330	COG1169	isochorismate synthase
HLB41_RS03340	COG0596	Alpha beta hydrolase
HLB41_RS03345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HLB41_RS03355	COG4948	Mandelate Racemase Muconate Lactonizing
HLB41_RS03375	COG3964	amidohydrolase
HLB41_RS03395	COG2188	Transcriptional regulator
HLB41_RS03420	COG0577	efflux transmembrane transporter activity
HLB41_RS03425	COG1136	(ABC) transporter
HLB41_RS03430	COG0577	efflux transmembrane transporter activity
HLB41_RS03435	COG0577	efflux transmembrane transporter activity
HLB41_RS03440	COG2205	protein histidine kinase activity
HLB41_RS03445	COG0745	RESPONSE REGULATOR receiver
HLB41_RS03450	COG0640	Transcriptional regulator
HLB41_RS03455	COG5658	integral membrane protein
HLB41_RS03460	COG2207	Transcriptional regulator
HLB41_RS03460	COG3708	Transcriptional regulator
HLB41_RS03465	COG1136	(ABC) transporter
HLB41_RS03470	COG0577	efflux transmembrane transporter activity
HLB41_RS03480	COG0586	Pfam SNARE associated Golgi protein
HLB41_RS03495	COG1136	(ABC) transporter
HLB41_RS03500	COG0577	efflux transmembrane transporter activity
HLB41_RS03540	COG1597	lipid kinase activity
HLB41_RS03570	COG0745	RESPONSE REGULATOR receiver
HLB41_RS03575	COG5002	protein histidine kinase activity
HLB41_RS03605	COG1842	Phage shock protein A
HLB41_RS03625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_RS03640	COG1294	oxidase, subunit
HLB41_RS03645	COG1271	oxidase subunit
HLB41_RS03650	COG0288	reversible hydration of carbon dioxide
HLB41_RS03660	COG1854	S-ribosylhomocysteine lyase activity
HLB41_RS03690	COG0494	nUDIX hydrolase
HLB41_RS03715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB41_RS03720	COG1116	anion transmembrane transporter activity
HLB41_RS03725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB41_RS03740	COG1368	sulfuric ester hydrolase activity
HLB41_RS03745	COG2267	carboxylic ester hydrolase activity
HLB41_RS03760	COG3852	Histidine kinase
HLB41_RS03765	COG5002	protein histidine kinase activity
HLB41_RS03810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS03830	COG0438	transferase activity, transferring glycosyl groups
HLB41_RS03835	COG0671	phosphoesterase, PA-phosphatase related
HLB41_RS03840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HLB41_RS03845	COG2267	carboxylic ester hydrolase activity
HLB41_RS03860	COG1794	racemase activity, acting on amino acids and derivatives
HLB41_RS03875	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HLB41_RS03880	COG1242	4 iron, 4 sulfur cluster binding
HLB41_RS03900	COG1136	(ABC) transporter
HLB41_RS03910	COG0582	viral genome integration into host DNA
HLB41_RS03915	COG0490	domain, Protein
HLB41_RS03920	COG0475	glutathione-regulated potassium exporter activity
HLB41_RS03925	COG2814	Major facilitator Superfamily
HLB41_RS03965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB41_RS03975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_RS03995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLB41_RS04000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLB41_RS04010	COG0303	'Molybdopterin
HLB41_RS04015	COG1763	Mo-molybdopterin cofactor biosynthetic process
HLB41_RS04020	COG0314	molybdopterin synthase activity
HLB41_RS04045	COG1329	Transcriptional regulator
HLB41_RS04065	COG3832	glyoxalase III activity
HLB41_RS04075	COG2814	Major facilitator Superfamily
HLB41_RS04080	COG2081	HI0933 family
HLB41_RS04085	COG2244	polysaccharide biosynthetic process
HLB41_RS04090	COG1187	pseudouridine synthase activity
HLB41_RS04095	COG1349	DNA-binding transcription factor activity
HLB41_RS04100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB41_RS04110	COG1523	belongs to the glycosyl hydrolase 13 family
HLB41_RS04115	COG0510	thiamine kinase activity
HLB41_RS04130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_RS04140	COG1363	Peptidase, m42
HLB41_RS04145	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HLB41_RS04150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_RS04160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLB41_RS04170	COG1388	LysM domain
HLB41_RS04170	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_RS04175	COG1674	ftsk spoiiie
HLB41_RS04190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS04215	COG2309	aminopeptidase activity
HLB41_RS04225	COG3118	belongs to the thioredoxin family
HLB41_RS04230	COG4851	CamS sex pheromone cAM373 precursor
HLB41_RS04235	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HLB41_RS04235	COG1605	Chorismate mutase
HLB41_RS04240	COG1609	Transcriptional regulator
HLB41_RS04275	COG0666	response to abiotic stimulus
HLB41_RS04285	COG0745	RESPONSE REGULATOR receiver
HLB41_RS04300	COG0123	including yeast histone deacetylase and acetoin utilization protein
HLB41_RS04305	COG0517	IMP dehydrogenase activity
HLB41_RS04310	COG0454	-acetyltransferase
HLB41_RS04315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB41_RS04320	COG0110	maltose O-acetyltransferase activity
HLB41_RS04355	COG0626	cystathionine gamma-synthase activity
HLB41_RS04360	COG1956	GAF domain-containing protein
HLB41_RS04365	COG1309	transcriptional regulator
HLB41_RS04370	COG0697	spore germination
HLB41_RS04375	COG0583	DNA-binding transcription factor activity
HLB41_RS04385	COG1104	cysteine desulfurase activity
HLB41_RS04400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB41_RS04410	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HLB41_RS04425	COG3874	Sporulation protein YtfJ
HLB41_RS04435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HLB41_RS04440	COG0827	DNA restriction-modification system
HLB41_RS04465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_RS04505	COG0589	response to stress
HLB41_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS04525	COG0662	Cupin 2, conserved barrel domain protein
HLB41_RS04530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS04565	COG0006	proline dipeptidase activity
HLB41_RS04580	COG4109	DRTGG domain
HLB41_RS04595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLB41_RS04610	COG0587	DNA-directed DNA polymerase activity
HLB41_RS04615	COG0281	malic enzyme
HLB41_RS04620	COG1725	Transcriptional regulator
HLB41_RS04645	COG3030	protein affecting phage T7 exclusion by the F plasmid
HLB41_RS04650	COG0628	permease
HLB41_RS04660	COG0372	Belongs to the citrate synthase family
HLB41_RS04665	COG0538	isocitrate dehydrogenase activity
HLB41_RS04685	COG0745	RESPONSE REGULATOR receiver
HLB41_RS04690	COG5002	protein histidine kinase activity
HLB41_RS04695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLB41_RS04695	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLB41_RS04705	COG1971	Probably functions as a manganese efflux pump
HLB41_RS04715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLB41_RS04720	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HLB41_RS04730	COG3611	Membrane attachment protein
HLB41_RS04735	COG1484	DNA-dependent DNA replication
HLB41_RS04750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLB41_RS04775	COG1363	Peptidase, m42
HLB41_RS04780	COG1309	transcriptional regulator
HLB41_RS04785	COG1566	PFAM secretion protein HlyD family protein
HLB41_RS04790	COG2814	Major facilitator Superfamily
HLB41_RS04800	COG1418	mRNA catabolic process
HLB41_RS04810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLB41_RS04850	COG1286	toxin biosynthetic process
HLB41_RS04855	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLB41_RS04855	COG1796	DNA polymerase
HLB41_RS04865	COG1187	pseudouridine synthase activity
HLB41_RS04870	COG1114	Component of the transport system for branched-chain amino acids
HLB41_RS04875	COG5386	Cell surface protein
HLB41_RS04885	COG5386	Cell surface protein
HLB41_RS04900	COG1120	ATPase activity
HLB41_RS04905	COG4509	Sortase family
HLB41_RS04915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLB41_RS04920	COG4895	conserved protein (DUF2196)
HLB41_RS04930	COG0745	RESPONSE REGULATOR receiver
HLB41_RS04935	COG2205	protein histidine kinase activity
HLB41_RS04940	COG1131	(ABC) transporter
HLB41_RS04965	COG2318	DinB family
HLB41_RS04990	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_RS04995	COG1309	transcriptional regulator
HLB41_RS05000	COG1024	Enoyl-CoA hydratase
HLB41_RS05005	COG2086	electron transfer activity
HLB41_RS05010	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HLB41_RS05015	COG3118	belongs to the thioredoxin family
HLB41_RS05025	COG1719	4-vinyl reductase, 4VR
HLB41_RS05030	COG2009	succinate dehydrogenase
HLB41_RS05035	COG1053	succinate dehydrogenase
HLB41_RS05040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLB41_RS05045	COG0824	Thioesterase
HLB41_RS05050	COG1876	peptidase activity
HLB41_RS05055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HLB41_RS05060	COG1360	Flagellar Motor Protein
HLB41_RS05065	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HLB41_RS05070	COG4152	abc transporter atp-binding protein
HLB41_RS05075	COG1668	transmembrane transport
HLB41_RS05080	COG1959	2 iron, 2 sulfur cluster binding
HLB41_RS05090	COG0697	spore germination
HLB41_RS05095	COG1396	sequence-specific DNA binding
HLB41_RS05100	COG1983	PspC domain protein
HLB41_RS05105	COG0402	S-adenosylhomocysteine deaminase activity
HLB41_RS05110	COG2233	PERMEase
HLB41_RS05115	COG2197	response regulator
HLB41_RS05140	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLB41_RS05205	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HLB41_RS05210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLB41_RS05215	COG1999	signal sequence binding
HLB41_RS05245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB41_RS05255	COG2197	response regulator
HLB41_RS05265	COG1309	transcriptional regulator
HLB41_RS05285	COG5401	PFAM Sporulation and spore germination
HLB41_RS05300	COG0622	Phosphoesterase
HLB41_RS05345	COG1067	ATP-dependent peptidase activity
HLB41_RS05345	COG0470	DNA polymerase III
HLB41_RS05360	COG1764	response to oxidative stress
HLB41_RS05365	COG1846	Transcriptional regulator
HLB41_RS05375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLB41_RS05385	COG1587	Uroporphyrinogen-III synthase
HLB41_RS05390	COG0113	porphobilinogen synthase activity
HLB41_RS05400	COG1388	LysM domain
HLB41_RS05415	COG0285	dihydrofolate synthase activity
HLB41_RS05435	COG1077	Cell shape determining protein MreB Mrl
HLB41_RS05455	COG2894	cell division
HLB41_RS05460	COG0739	heme binding
HLB41_RS05465	COG1994	Peptidase M50
HLB41_RS05470	COG1530	ribonuclease E activity
HLB41_RS05480	COG2868	ribosomal protein
HLB41_RS05490	COG3290	protein histidine kinase activity
HLB41_RS05500	COG0745	RESPONSE REGULATOR receiver
HLB41_RS05505	COG5002	protein histidine kinase activity
HLB41_RS05510	COG1136	(ABC) transporter
HLB41_RS05515	COG0577	efflux transmembrane transporter activity
HLB41_RS05520	COG0577	efflux transmembrane transporter activity
HLB41_RS05525	COG0077	Prephenate dehydratase
HLB41_RS05530	COG2258	MOSC domain
HLB41_RS05535	COG1827	regulation of RNA biosynthetic process
HLB41_RS05540	COG1104	cysteine desulfurase activity
HLB41_RS05545	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HLB41_RS05550	COG0157	Belongs to the NadC ModD family
HLB41_RS05580	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HLB41_RS05610	COG1862	Preprotein translocase
HLB41_RS05620	COG2323	membrane
HLB41_RS05625	COG2244	polysaccharide biosynthetic process
HLB41_RS05635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLB41_RS05635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLB41_RS05640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLB41_RS05645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HLB41_RS05645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLB41_RS05655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLB41_RS05680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLB41_RS05690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLB41_RS05695	COG1959	2 iron, 2 sulfur cluster binding
HLB41_RS05700	COG1104	cysteine desulfurase activity
HLB41_RS05715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLB41_RS05735	COG0628	permease
HLB41_RS05765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLB41_RS05770	COG4122	O-methyltransferase activity
HLB41_RS05800	COG0768	penicillin binding
HLB41_RS05825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLB41_RS05830	COG0626	cystathionine gamma-synthase activity
HLB41_RS05835	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_RS05835	COG1454	alcohol dehydrogenase
HLB41_RS05845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_RS05885	COG2259	Doxx family
HLB41_RS05890	COG2514	catechol 2,3-dioxygenase activity
HLB41_RS05900	COG3186	Phenylalanine-4-hydroxylase
HLB41_RS05905	COG1404	Belongs to the peptidase S8 family
HLB41_RS05940	COG2267	carboxylic ester hydrolase activity
HLB41_RS05950	COG1785	Belongs to the alkaline phosphatase family
HLB41_RS05960	COG2357	RelA SpoT domain protein
HLB41_RS05965	COG0778	Nitroreductase
HLB41_RS06000	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HLB41_RS06005	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HLB41_RS06015	COG1534	Rna-binding protein
HLB41_RS06025	COG1713	HD superfamily hydrolase involved in NAD metabolism
HLB41_RS06030	COG0799	negative regulation of ribosome biogenesis
HLB41_RS06035	COG2226	methyltransferase
HLB41_RS06040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLB41_RS06045	COG1596	polysaccharide export
HLB41_RS06045	COG1555	photosystem II stabilization
HLB41_RS06050	COG2131	deaminase
HLB41_RS06055	COG0658	competence protein
HLB41_RS06055	COG2333	competence protein COMEC
HLB41_RS06065	COG1466	dna polymerase III delta subunit
HLB41_RS06090	COG1733	regulation of RNA biosynthetic process
HLB41_RS06095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLB41_RS06125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLB41_RS06130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLB41_RS06135	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HLB41_RS06140	COG1610	YqeY-like protein
HLB41_RS06155	COG1702	phosphate starvation-inducible protein PhoH
HLB41_RS06160	COG1480	7TM receptor with intracellular HD hydrolase
HLB41_RS06170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HLB41_RS06175	COG0295	cytidine deaminase activity
HLB41_RS06180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLB41_RS06195	COG0517	IMP dehydrogenase activity
HLB41_RS06205	COG1671	Belongs to the UPF0178 family
HLB41_RS06210	COG0358	DNA primase activity
HLB41_RS06215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLB41_RS06225	COG2384	SAM-dependent methyltransferase
HLB41_RS06230	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLB41_RS06260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_RS06265	COG1121	(ABC) transporter
HLB41_RS06270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLB41_RS06275	COG0735	belongs to the Fur family
HLB41_RS06290	COG5521	maltodextrose utilization protein MalA
HLB41_RS06300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLB41_RS06305	COG0477	Major facilitator Superfamily
HLB41_RS06315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLB41_RS06320	COG0573	inorganic phosphate transmembrane transporter activity
HLB41_RS06325	COG0573	inorganic phosphate transmembrane transporter activity
HLB41_RS06335	COG0704	Plays a role in the regulation of phosphate uptake
HLB41_RS06340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HLB41_RS06345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLB41_RS06350	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLB41_RS06355	COG4483	Protein conserved in bacteria
HLB41_RS06360	COG1940	carbohydrate kinase activity
HLB41_RS06370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_RS06390	COG0626	cystathionine gamma-synthase activity
HLB41_RS06395	COG0626	cystathionine gamma-synthase activity
HLB41_RS06400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLB41_RS06400	COG0646	methionine synthase
HLB41_RS06405	COG0646	methionine synthase
HLB41_RS06405	COG1410	methionine synthase
HLB41_RS06460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLB41_RS06465	COG1459	type II secretion system
HLB41_RS06515	COG2264	protein methyltransferase activity
HLB41_RS06540	COG2169	Transcriptional regulator
HLB41_RS06545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLB41_RS06575	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HLB41_RS06580	COG2169	Transcriptional regulator
HLB41_RS06620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLB41_RS06650	COG1725	Transcriptional regulator
HLB41_RS06655	COG1131	(ABC) transporter
HLB41_RS06690	COG2076	Multidrug Resistance protein
HLB41_RS06695	COG2076	Multidrug Resistance protein
HLB41_RS06705	COG1609	Transcriptional regulator
HLB41_RS06715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_RS06750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLB41_RS06760	COG3872	metal-dependent enzyme
HLB41_RS06775	COG0006	proline dipeptidase activity
HLB41_RS06800	COG3854	ATPases associated with a variety of cellular activities
HLB41_RS06845	COG0511	ligase activity, forming carbon-carbon bonds
HLB41_RS06850	COG0439	Biotin carboxylase
HLB41_RS06855	COG1302	Protein conserved in bacteria
HLB41_RS06880	COG0142	geranyltranstransferase activity
HLB41_RS06890	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HLB41_RS06900	COG0497	DNA recombination
HLB41_RS06905	COG0750	zinc metalloprotease
HLB41_RS06920	COG3093	addiction module antidote protein HigA
HLB41_RS06925	COG0584	glycerophosphoryl diester phosphodiesterase
HLB41_RS06935	COG3829	transcription factor binding
HLB41_RS06935	COG3290	protein histidine kinase activity
HLB41_RS06940	COG0280	phosphate acetyltransferase
HLB41_RS06955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB41_RS06960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLB41_RS06965	COG0022	dehydrogenase e1 component
HLB41_RS06970	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLB41_RS06975	COG0772	Belongs to the SEDS family
HLB41_RS06980	COG2323	membrane
HLB41_RS07000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB41_RS07005	COG0765	amino acid transport
HLB41_RS07010	COG1126	abc transporter atp-binding protein
HLB41_RS07015	COG4129	membrane
HLB41_RS07020	COG1376	ErfK ybiS ycfS ynhG family protein
HLB41_RS07035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS07040	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLB41_RS07050	COG1285	pathogenesis
HLB41_RS07080	COG1760	l-serine dehydratase
HLB41_RS07085	COG1760	l-serine dehydratase
HLB41_RS07090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLB41_RS07095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_RS07100	COG0300	oxidoreductase activity
HLB41_RS07145	COG1522	sequence-specific DNA binding
HLB41_RS07155	COG0737	Belongs to the 5'-nucleotidase family
HLB41_RS07170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB41_RS07185	COG2226	methyltransferase
HLB41_RS07185	COG1073	alpha beta
HLB41_RS07215	COG0307	riboflavin synthase, alpha
HLB41_RS07220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB41_RS07220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB41_RS07235	COG1073	alpha beta
HLB41_RS07240	COG0456	acetyltransferase
HLB41_RS07245	COG1609	Transcriptional regulator
HLB41_RS07250	COG2056	Na+-H+ antiporter family
HLB41_RS07255	COG0596	Alpha beta hydrolase
HLB41_RS07265	COG4085	toxin activity
HLB41_RS07265	COG1525	nuclease
HLB41_RS07265	COG0737	Belongs to the 5'-nucleotidase family
HLB41_RS07275	COG0456	acetyltransferase
HLB41_RS07275	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HLB41_RS07280	COG0656	L-ascorbic acid biosynthetic process
HLB41_RS07285	COG0667	Aldo Keto reductase
HLB41_RS07305	COG1300	Membrane
HLB41_RS07310	COG0735	belongs to the Fur family
HLB41_RS07320	COG4974	Belongs to the 'phage' integrase family
HLB41_RS07345	COG0598	Magnesium transport protein CorA
HLB41_RS07360	COG1846	Transcriptional regulator
HLB41_RS07380	COG1131	(ABC) transporter
HLB41_RS07385	COG1725	Transcriptional regulator
HLB41_RS07390	COG1686	Belongs to the peptidase S11 family
HLB41_RS07410	COG0733	neurotransmitter:sodium symporter activity
HLB41_RS07435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLB41_RS07450	COG0697	spore germination
HLB41_RS07455	COG0561	phosphatase activity
HLB41_RS07460	COG4086	secreted protein
HLB41_RS07465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLB41_RS07470	COG0456	acetyltransferase
HLB41_RS07475	COG1547	Domain of unknown function (DUF309)
HLB41_RS07500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLB41_RS07510	COG2188	Transcriptional regulator
HLB41_RS07520	COG3711	transcriptional antiterminator
HLB41_RS07525	COG1263	PTS System
HLB41_RS07525	COG2190	(PTS) system
HLB41_RS07525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_RS07550	COG0778	Nitroreductase
HLB41_RS07555	COG2199	diguanylate cyclase activity
HLB41_RS07555	COG2203	Gaf domain
HLB41_RS07565	COG2084	Dehydrogenase
HLB41_RS07600	COG0436	Aminotransferase
HLB41_RS07605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLB41_RS07625	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS07630	COG1695	Transcriptional regulator
HLB41_RS07660	COG0183	Belongs to the thiolase family
HLB41_RS07700	COG3842	ATPase activity
HLB41_RS07705	COG0366	Alpha amylase catalytic
HLB41_RS07715	COG2182	Extracellular solute-binding protein
HLB41_RS07720	COG1175	transmembrane transport
HLB41_RS07725	COG3833	ABC-type maltose transport systems, permease component
HLB41_RS07730	COG1609	Transcriptional regulator
HLB41_RS07735	COG0436	Aminotransferase
HLB41_RS07745	COG2205	protein histidine kinase activity
HLB41_RS07755	COG3209	COG3209 Rhs family protein
HLB41_RS07775	COG2814	Major facilitator Superfamily
HLB41_RS07820	COG1408	metallophosphoesterase
HLB41_RS07825	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS07830	COG2200	EAL domain
HLB41_RS07845	COG4703	Protein of unknown function (DUF1797)
HLB41_RS07855	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HLB41_RS07865	COG0517	IMP dehydrogenase activity
HLB41_RS07870	COG0583	DNA-binding transcription factor activity
HLB41_RS07890	COG0569	domain protein
HLB41_RS07895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLB41_RS07905	COG0561	phosphatase activity
HLB41_RS07920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLB41_RS07925	COG0022	dehydrogenase e1 component
HLB41_RS07975	COG1982	Orn Lys Arg decarboxylase major
HLB41_RS07995	COG0483	inositol monophosphate 1-phosphatase activity
HLB41_RS08020	COG4896	Protein conserved in bacteria
HLB41_RS08030	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HLB41_RS08035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLB41_RS08045	COG0772	Belongs to the SEDS family
HLB41_RS08050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HLB41_RS08085	COG3336	cytochrome c oxidase
HLB41_RS08095	COG3344	reverse transcriptase
HLB41_RS08110	COG2340	Cysteine-rich secretory protein family
HLB41_RS08125	COG0406	alpha-ribazole phosphatase activity
HLB41_RS08130	COG3679	Belongs to the UPF0342 family
HLB41_RS08145	COG0742	ribosomal rna small subunit methyltransferase
HLB41_RS08155	COG3314	Sporulation integral membrane protein YlbJ
HLB41_RS08160	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLB41_RS08165	COG3480	Lon protease (S16) C-terminal proteolytic domain
HLB41_RS08175	COG1399	metal-binding, possibly nucleic acid-binding protein
HLB41_RS08180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HLB41_RS08195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLB41_RS08220	COG0768	penicillin binding
HLB41_RS08240	COG0772	Belongs to the SEDS family
HLB41_RS08260	COG0849	cell division
HLB41_RS08265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLB41_RS08275	COG1191	sigma factor activity
HLB41_RS08280	COG1191	sigma factor activity
HLB41_RS08285	COG1873	PFAM PRC-barrel domain
HLB41_RS08295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLB41_RS08300	COG1799	cell septum assembly
HLB41_RS08305	COG0762	integral membrane protein
HLB41_RS08310	COG2302	S4 RNA-binding domain
HLB41_RS08315	COG3599	regulation of cell shape
HLB41_RS08335	COG0564	pseudouridine synthase activity
HLB41_RS08400	COG3069	C4-dicarboxylate transmembrane transporter activity
HLB41_RS08410	COG0006	proline dipeptidase activity
HLB41_RS08420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLB41_RS08425	COG1561	YicC-like family, N-terminal region
HLB41_RS08445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLB41_RS08450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLB41_RS08465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLB41_RS08465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLB41_RS08475	COG0631	protein serine/threonine phosphatase activity
HLB41_RS08480	COG2815	serine threonine protein kinase
HLB41_RS08480	COG0515	serine threonine protein kinase
HLB41_RS08490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLB41_RS08495	COG1564	THIamine pyrophosphokinase
HLB41_RS08510	COG1302	Protein conserved in bacteria
HLB41_RS08515	COG1461	Dihydroxyacetone kinase
HLB41_RS08520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLB41_RS08535	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLB41_RS08540	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS08545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLB41_RS08555	COG1196	nuclear chromosome segregation
HLB41_RS08560	COG0552	protein localization to endoplasmic reticulum
HLB41_RS08570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLB41_RS08580	COG1837	Belongs to the UPF0109 family
HLB41_RS08620	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HLB41_RS08625	COG0758	DNA mediated transformation
HLB41_RS08630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLB41_RS08640	COG4974	Belongs to the 'phage' integrase family
HLB41_RS08685	COG4589	Belongs to the CDS family
HLB41_RS08695	COG0750	zinc metalloprotease
HLB41_RS08715	COG0195	Participates in both transcription termination and antitermination
HLB41_RS08720	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HLB41_RS08725	COG1358	cellular component organization or biogenesis
HLB41_RS08735	COG1550	Protein conserved in bacteria
HLB41_RS08740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HLB41_RS08750	COG0196	riboflavin kinase activity
HLB41_RS08765	COG0726	polysaccharide deacetylase
HLB41_RS08770	COG0612	Peptidase, M16
HLB41_RS08775	COG1873	PFAM PRC-barrel domain
HLB41_RS08780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLB41_RS08785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLB41_RS08790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLB41_RS08795	COG0527	aspartate kinase activity
HLB41_RS08805	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLB41_RS08810	COG0740	serine-type endopeptidase activity
HLB41_RS08825	COG2188	Transcriptional regulator
HLB41_RS08850	COG0612	Peptidase, M16
HLB41_RS08855	COG0612	Peptidase, M16
HLB41_RS08860	COG0300	oxidoreductase activity
HLB41_RS08875	COG1426	Protein conserved in bacteria
HLB41_RS08880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLB41_RS08900	COG1692	metallophosphoesterase
HLB41_RS08905	COG2359	stage V sporulation protein S
HLB41_RS08915	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HLB41_RS08915	COG0674	pyruvate-flavodoxin oxidoreductase activity
HLB41_RS08920	COG1013	pyruvate-flavodoxin oxidoreductase activity
HLB41_RS08930	COG4550	Control of competence regulator ComK, YlbF/YmcA
HLB41_RS08955	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLB41_RS08960	COG1368	sulfuric ester hydrolase activity
HLB41_RS08970	COG3773	Cell wall hydrolase
HLB41_RS08975	COG1404	Belongs to the peptidase S8 family
HLB41_RS08985	COG2723	6-phospho-beta-galactosidase activity
HLB41_RS08990	COG2188	Transcriptional regulator
HLB41_RS09000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_RS09010	COG1346	cytolysis
HLB41_RS09030	COG1086	Polysaccharide biosynthesis protein
HLB41_RS09050	COG5001	Diguanylate cyclase
HLB41_RS09050	COG3300	MHYT domain
HLB41_RS09055	COG2267	carboxylic ester hydrolase activity
HLB41_RS09075	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HLB41_RS09080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLB41_RS09085	COG2169	Transcriptional regulator
HLB41_RS09090	COG0708	Exodeoxyribonuclease III
HLB41_RS09095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_RS09100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_RS09105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_RS09110	COG1120	ATPase activity
HLB41_RS09115	COG2819	hydrolase of the alpha beta superfamily
HLB41_RS09125	COG1937	Protein conserved in bacteria
HLB41_RS09130	COG2608	mercury ion transmembrane transporter activity
HLB41_RS09135	COG2217	Heavy metal translocating P-type atpase
HLB41_RS09150	COG2116	formate transmembrane transporter activity
HLB41_RS09155	COG1408	metallophosphoesterase
HLB41_RS09165	COG1113	amino acid transport
HLB41_RS09175	COG2322	membrane
HLB41_RS09180	COG1979	alcohol dehydrogenase
HLB41_RS09185	COG1349	DNA-binding transcription factor activity
HLB41_RS09190	COG1105	Belongs to the carbohydrate kinase PfkB family
HLB41_RS09195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB41_RS09195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLB41_RS09195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLB41_RS09200	COG3584	3D domain protein
HLB41_RS09200	COG1388	LysM domain
HLB41_RS09230	COG0464	growth
HLB41_RS09240	COG2860	membrane
HLB41_RS09245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLB41_RS09250	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HLB41_RS09255	COG0789	Transcriptional regulator
HLB41_RS09260	COG0174	glutamine synthetase
HLB41_RS09265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLB41_RS09300	COG0741	lytic transglycosylase activity
HLB41_RS09305	COG0739	heme binding
HLB41_RS09310	COG5632	N-Acetylmuramoyl-L-alanine amidase
HLB41_RS09310	COG3409	Peptidoglycan-binding domain 1 protein
HLB41_RS09310	COG1388	LysM domain
HLB41_RS09320	COG1695	Transcriptional regulator
HLB41_RS09340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB41_RS09350	COG0737	Belongs to the 5'-nucleotidase family
HLB41_RS09355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB41_RS09365	COG3639	organic phosphonate transmembrane transporter activity
HLB41_RS09390	COG1132	(ABC) transporter
HLB41_RS09395	COG1132	(ABC) transporter
HLB41_RS09420	COG0730	response to heat
HLB41_RS09435	COG1346	cytolysis
HLB41_RS09445	COG0583	DNA-binding transcription factor activity
HLB41_RS09460	COG1131	(ABC) transporter
HLB41_RS09470	COG1473	amidohydrolase
HLB41_RS09480	COG0785	Cytochrome C biogenesis protein
HLB41_RS09485	COG4846	Membrane protein involved in cytochrome C biogenesis
HLB41_RS09535	COG0010	Belongs to the arginase family
HLB41_RS09540	COG1329	Transcriptional regulator
HLB41_RS09545	COG1902	pentaerythritol trinitrate reductase activity
HLB41_RS09550	COG0069	glutamate synthase activity
HLB41_RS09560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB41_RS09565	COG0346	lactoylglutathione lyase activity
HLB41_RS09570	COG0400	carboxylic ester hydrolase activity
HLB41_RS09575	COG5002	protein histidine kinase activity
HLB41_RS09585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_RS09620	COG1396	sequence-specific DNA binding
HLB41_RS09625	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_RS09630	COG1268	BioY protein
HLB41_RS09635	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_RS09640	COG0183	Belongs to the thiolase family
HLB41_RS09655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLB41_RS09665	COG2211	Major facilitator Superfamily
HLB41_RS09695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLB41_RS09700	COG1132	(ABC) transporter
HLB41_RS09715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_RS09740	COG0824	Thioesterase
HLB41_RS09745	COG4841	protein insertion into membrane
HLB41_RS09765	COG0745	RESPONSE REGULATOR receiver
HLB41_RS09770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB41_RS09775	COG1832	CoA-binding protein
HLB41_RS09780	COG0187	DNA topoisomerase II activity
HLB41_RS09785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLB41_RS09790	COG0673	inositol 2-dehydrogenase activity
HLB41_RS09825	COG1131	(ABC) transporter
HLB41_RS09835	COG1595	DNA-templated transcription, initiation
HLB41_RS09845	COG1316	TRANSCRIPTIONal
HLB41_RS09850	COG1301	dicarboxylic acid transport
HLB41_RS09855	COG4166	transmembrane transport
HLB41_RS09860	COG4166	transmembrane transport
HLB41_RS09865	COG4166	transmembrane transport
HLB41_RS09870	COG2226	methyltransferase
HLB41_RS09905	COG0531	amino acid
HLB41_RS09925	COG3383	formate dehydrogenase (NAD+) activity
HLB41_RS09930	COG2427	Protein of unknown function (DUF1641)
HLB41_RS09935	COG5609	conserved protein (DUF2294)
HLB41_RS09940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLB41_RS09950	COG2116	formate transmembrane transporter activity
HLB41_RS09955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLB41_RS09960	COG0303	'Molybdopterin
HLB41_RS09965	COG0314	molybdopterin synthase activity
HLB41_RS09975	COG0489	protein tyrosine kinase activity
HLB41_RS09990	COG3326	Membrane
HLB41_RS09995	COG2962	Rard protein
HLB41_RS10000	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HLB41_RS10005	COG1657	PFAM Prenyltransferase squalene oxidase
HLB41_RS10015	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS10020	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_RS10030	COG4145	pantothenate transmembrane transporter activity
HLB41_RS10045	COG0165	Argininosuccinate lyase
HLB41_RS10055	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS10075	COG0494	nUDIX hydrolase
HLB41_RS10085	COG0716	FMN binding
HLB41_RS10120	COG2720	vancomycin resistance protein
HLB41_RS10125	COG2514	catechol 2,3-dioxygenase activity
HLB41_RS10135	COG1285	pathogenesis
HLB41_RS10175	COG0277	FAD linked oxidase domain protein
HLB41_RS10195	COG2808	Putative FMN-binding domain
HLB41_RS10205	COG0457	Tetratricopeptide repeat
HLB41_RS10215	COG0604	alcohol dehydrogenase
HLB41_RS10220	COG0640	Transcriptional regulator
HLB41_RS10235	COG0584	glycerophosphoryl diester phosphodiesterase
HLB41_RS10260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLB41_RS10275	COG3781	membrane
HLB41_RS10300	COG1164	Oligoendopeptidase f
HLB41_RS10305	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HLB41_RS10320	COG1193	negative regulation of DNA recombination
HLB41_RS10340	COG0583	DNA-binding transcription factor activity
HLB41_RS10370	COG3739	integral membrane protein
HLB41_RS10375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_RS10380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_RS10385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_RS10400	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLB41_RS10405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLB41_RS10430	COG2814	Major facilitator Superfamily
HLB41_RS10435	COG1113	amino acid transport
HLB41_RS10470	COG2072	flavoprotein involved in K transport
HLB41_RS10495	COG1151	hydroxylamine reductase activity
HLB41_RS10575	COG1191	sigma factor activity
HLB41_RS10585	COG0726	polysaccharide deacetylase
HLB41_RS10600	COG1733	regulation of RNA biosynthetic process
HLB41_RS10605	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLB41_RS10610	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_RS10615	COG0384	phenazine biosynthesis protein PhzF
HLB41_RS10635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_RS10655	COG1733	regulation of RNA biosynthetic process
HLB41_RS10660	COG1733	regulation of RNA biosynthetic process
HLB41_RS10665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLB41_RS10670	COG0673	inositol 2-dehydrogenase activity
HLB41_RS10675	COG2188	Transcriptional regulator
HLB41_RS10680	COG1733	regulation of RNA biosynthetic process
HLB41_RS10710	COG0814	amino acid
HLB41_RS10735	COG2814	Major facilitator Superfamily
HLB41_RS10740	COG0656	L-ascorbic acid biosynthetic process
HLB41_RS10755	COG1733	regulation of RNA biosynthetic process
HLB41_RS10760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLB41_RS10760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLB41_RS10765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB41_RS10765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB41_RS10775	COG0840	transmembrane signaling receptor activity
HLB41_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS10800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB41_RS10805	COG0604	alcohol dehydrogenase
HLB41_RS10815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HLB41_RS10820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLB41_RS10825	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HLB41_RS10840	COG1070	Carbohydrate kinase
HLB41_RS10845	COG2706	6-phosphogluconolactonase activity
HLB41_RS10850	COG3813	Protein conserved in bacteria
HLB41_RS10855	COG1357	PFAM Pentapeptide repeats (8 copies)
HLB41_RS10865	COG0697	spore germination
HLB41_RS10870	COG0789	Transcriptional regulator
HLB41_RS10875	COG1253	flavin adenine dinucleotide binding
HLB41_RS10930	COG0628	permease
HLB41_RS10975	COG1011	Hydrolase
HLB41_RS11000	COG1131	(ABC) transporter
HLB41_RS11010	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS11040	COG0778	Nitroreductase
HLB41_RS11045	COG1733	regulation of RNA biosynthetic process
HLB41_RS11065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLB41_RS11085	COG2356	endonuclease I
HLB41_RS11090	COG1288	antiporter activity
HLB41_RS11145	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLB41_RS11155	COG2031	fatty acid transporter
HLB41_RS11175	COG1131	(ABC) transporter
HLB41_RS11180	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HLB41_RS11190	COG2814	Major facilitator Superfamily
HLB41_RS11195	COG1846	Transcriptional regulator
HLB41_RS11210	COG0477	Major facilitator Superfamily
HLB41_RS11220	COG2843	Capsule synthesis protein
HLB41_RS11225	COG1876	peptidase activity
HLB41_RS11250	COG5444	nuclease activity
HLB41_RS11255	COG2849	repeat protein
HLB41_RS11485	COG5632	N-Acetylmuramoyl-L-alanine amidase
HLB41_RS11485	COG3409	Peptidoglycan-binding domain 1 protein
HLB41_RS11510	COG2207	Transcriptional regulator
HLB41_RS11510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_RS11515	COG0662	Cupin 2, conserved barrel domain protein
HLB41_RS11535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLB41_RS11555	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLB41_RS11580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_RS11590	COG5002	protein histidine kinase activity
HLB41_RS11590	COG3850	Histidine kinase
HLB41_RS11610	COG0577	efflux transmembrane transporter activity
HLB41_RS11630	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HLB41_RS11645	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HLB41_RS11665	COG2814	Major facilitator Superfamily
HLB41_RS11715	COG3850	Histidine kinase
HLB41_RS11715	COG5002	protein histidine kinase activity
HLB41_RS11720	COG0745	RESPONSE REGULATOR receiver
HLB41_RS11780	COG1309	transcriptional regulator
HLB41_RS11830	COG0346	lactoylglutathione lyase activity
HLB41_RS11855	COG1522	sequence-specific DNA binding
HLB41_RS11860	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS11865	COG1309	transcriptional regulator
HLB41_RS11870	COG3320	Male sterility
HLB41_RS11870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLB41_RS11875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLB41_RS11885	COG0640	Transcriptional regulator
HLB41_RS11890	COG0346	lactoylglutathione lyase activity
HLB41_RS11895	COG0798	PFAM Bile acid sodium symporter
HLB41_RS11910	COG4154	Belongs to the RbsD FucU family
HLB41_RS11920	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB41_RS11930	COG0235	Class ii aldolase
HLB41_RS11935	COG1070	Carbohydrate kinase
HLB41_RS11945	COG3347	Dehydrogenase
HLB41_RS11945	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS11955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS11980	COG1575	Belongs to the MenA family. Type 1 subfamily
HLB41_RS11985	COG0456	acetyltransferase
HLB41_RS11995	COG0697	spore germination
HLB41_RS12010	COG5609	conserved protein (DUF2294)
HLB41_RS12015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLB41_RS12025	COG0288	reversible hydration of carbon dioxide
HLB41_RS12040	COG0415	Belongs to the DNA photolyase family
HLB41_RS12060	COG1073	alpha beta
HLB41_RS12080	COG0598	Magnesium transport protein CorA
HLB41_RS12085	COG1846	Transcriptional regulator
HLB41_RS12090	COG0583	DNA-binding transcription factor activity
HLB41_RS12110	COG1335	isochorismatase
HLB41_RS12115	COG2267	carboxylic ester hydrolase activity
HLB41_RS12120	COG0737	Belongs to the 5'-nucleotidase family
HLB41_RS12135	COG2124	cytochrome p450
HLB41_RS12145	COG1115	amino acid carrier protein
HLB41_RS12150	COG2066	Belongs to the glutaminase family
HLB41_RS12155	COG4191	Histidine kinase
HLB41_RS12165	COG0697	spore germination
HLB41_RS12170	COG0531	amino acid
HLB41_RS12185	COG0531	amino acid
HLB41_RS12190	COG0322	excinuclease ABC activity
HLB41_RS12205	COG2207	Transcriptional regulator
HLB41_RS12230	COG5002	protein histidine kinase activity
HLB41_RS12265	COG1396	sequence-specific DNA binding
HLB41_RS12270	COG0252	asparaginase activity
HLB41_RS12275	COG1027	Aspartate ammonia-lyase
HLB41_RS12285	COG1063	alcohol dehydrogenase
HLB41_RS12305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_RS12310	COG3848	Pyruvate phosphate dikinase
HLB41_RS12310	COG0574	Belongs to the PEP-utilizing enzyme family
HLB41_RS12370	COG1960	acyl-CoA dehydrogenase activity
HLB41_RS12380	COG0640	Transcriptional regulator
HLB41_RS12385	COG3142	Participates in the control of copper homeostasis
HLB41_RS12395	COG1414	Transcriptional regulator
HLB41_RS12400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HLB41_RS12405	COG1984	allophanate hydrolase subunit 2
HLB41_RS12470	COG4335	DNA alkylation repair
HLB41_RS12480	COG0833	amino acid
HLB41_RS12490	COG0730	response to heat
HLB41_RS12535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_RS12540	COG0697	spore germination
HLB41_RS12555	COG0456	acetyltransferase
HLB41_RS12585	COG1136	(ABC) transporter
HLB41_RS12600	COG4884	unkown
HLB41_RS12600	COG3831	ATPase activity
HLB41_RS12620	COG1846	Transcriptional regulator
HLB41_RS12625	COG0778	Nitroreductase
HLB41_RS12735	COG0714	Associated with various cellular activities
HLB41_RS12775	COG0753	catalase activity
HLB41_RS12780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLB41_RS12810	COG0463	Glycosyl transferase, family 2
HLB41_RS12835	COG0714	Associated with various cellular activities
HLB41_RS12860	COG0346	lactoylglutathione lyase activity
HLB41_RS12865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS12885	COG3655	Transcriptional regulator
HLB41_RS12895	COG1785	Belongs to the alkaline phosphatase family
HLB41_RS12900	COG2720	vancomycin resistance protein
HLB41_RS12910	COG3239	Fatty acid desaturase
HLB41_RS12920	COG0833	amino acid
HLB41_RS12925	COG1414	Transcriptional regulator
HLB41_RS12930	COG4187	Peptidase family M20/M25/M40
HLB41_RS12935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLB41_RS12950	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_RS12970	COG2329	Antibiotic biosynthesis monooxygenase
HLB41_RS12990	COG1070	Carbohydrate kinase
HLB41_RS12995	COG2390	Transcriptional regulator
HLB41_RS13005	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB41_RS13010	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB41_RS13015	COG1879	ABC-type sugar transport system periplasmic component
HLB41_RS13030	COG1309	transcriptional regulator
HLB41_RS13045	COG0346	lactoylglutathione lyase activity
HLB41_RS13055	COG1388	LysM domain
HLB41_RS13055	COG3584	3D domain protein
HLB41_RS13095	COG1605	Chorismate mutase
HLB41_RS13095	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HLB41_RS13110	COG0287	Prephenate dehydrogenase
HLB41_RS13125	COG1309	transcriptional regulator
HLB41_RS13130	COG2409	Drug exporters of the RND superfamily
HLB41_RS13130	COG1033	growth of symbiont in host cell
HLB41_RS13135	COG0488	(ABC) transporter
HLB41_RS13140	COG1368	sulfuric ester hydrolase activity
HLB41_RS13145	COG0861	Integral membrane protein TerC family
HLB41_RS13160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_RS13165	COG0346	lactoylglutathione lyase activity
HLB41_RS13170	COG4912	Dna alkylation repair
HLB41_RS13190	COG2318	DinB family
HLB41_RS13195	COG0697	spore germination
HLB41_RS13205	COG2746	aminoglycoside 3-N-acetyltransferase activity
HLB41_RS13245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB41_RS13250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB41_RS13255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB41_RS13265	COG0628	permease
HLB41_RS13315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLB41_RS13320	COG0436	Aminotransferase
HLB41_RS13355	COG2226	methyltransferase
HLB41_RS13370	COG2261	transglycosylase associated protein
HLB41_RS13395	COG4533	DNA binding
HLB41_RS13400	COG0789	Transcriptional regulator
HLB41_RS13405	COG1664	Polymer-forming cytoskeletal
HLB41_RS13415	COG2814	Major facilitator Superfamily
HLB41_RS13455	COG1307	EDD domain protein, DegV family
HLB41_RS13460	COG1164	Oligoendopeptidase f
HLB41_RS13500	COG0745	RESPONSE REGULATOR receiver
HLB41_RS13505	COG3850	Histidine kinase
HLB41_RS13505	COG5002	protein histidine kinase activity
HLB41_RS13550	COG0667	Aldo Keto reductase
HLB41_RS13565	COG4948	Mandelate Racemase Muconate Lactonizing
HLB41_RS13575	COG4166	transmembrane transport
HLB41_RS13585	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HLB41_RS13595	COG0586	Pfam SNARE associated Golgi protein
HLB41_RS13600	COG1078	dGTPase activity
HLB41_RS13640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB41_RS13645	COG3938	Belongs to the proline racemase family
HLB41_RS13655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLB41_RS13660	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_RS13665	COG1115	amino acid carrier protein
HLB41_RS13670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLB41_RS13685	COG3397	chitin binding
HLB41_RS13700	COG4637	Psort location Cytoplasmic, score
HLB41_RS13735	COG0514	ATP-dependent DNA helicase (RecQ)
HLB41_RS13750	COG3973	AAA domain
HLB41_RS13795	COG2315	Protein conserved in bacteria
HLB41_RS13800	COG2226	methyltransferase
HLB41_RS13805	COG2205	protein histidine kinase activity
HLB41_RS13825	COG1819	glycosyl
HLB41_RS13830	COG3397	chitin binding
HLB41_RS13835	COG2153	protein acetylation
HLB41_RS13865	COG4175	Glycine betaine
HLB41_RS13865	COG0517	IMP dehydrogenase activity
HLB41_RS13870	COG4176	ABC-type proline glycine betaine transport system permease component
HLB41_RS13900	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS13915	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLB41_RS13920	COG0022	dehydrogenase e1 component
HLB41_RS13925	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLB41_RS13930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB41_RS13945	COG1959	2 iron, 2 sulfur cluster binding
HLB41_RS13960	COG1349	DNA-binding transcription factor activity
HLB41_RS13975	COG3284	Transcriptional regulator
HLB41_RS14000	COG1309	transcriptional regulator
HLB41_RS14040	COG2959	enzyme of heme biosynthesis
HLB41_RS14055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS14085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB41_RS14090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_RS14095	COG0697	spore germination
HLB41_RS14100	COG0201	protein transport
HLB41_RS14120	COG0737	Belongs to the 5'-nucleotidase family
HLB41_RS14125	COG3227	Zinc metalloprotease (Elastase)
HLB41_RS14130	COG1523	belongs to the glycosyl hydrolase 13 family
HLB41_RS14135	COG1073	alpha beta
HLB41_RS14150	COG1011	Hydrolase
HLB41_RS14185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB41_RS14205	COG1131	(ABC) transporter
HLB41_RS14235	COG0322	excinuclease ABC activity
HLB41_RS14275	COG4667	esterase of the alpha-beta hydrolase superfamily
HLB41_RS14295	COG3878	Protein conserved in bacteria
HLB41_RS14300	COG0251	oxidation-reduction process
HLB41_RS14320	COG0592	DNA-directed DNA polymerase activity
HLB41_RS14340	COG2223	nitrite transmembrane transporter activity
HLB41_RS14385	COG0697	spore germination
HLB41_RS14390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_RS14410	COG0584	glycerophosphoryl diester phosphodiesterase
HLB41_RS14425	COG2814	Major facilitator Superfamily
HLB41_RS14480	COG0671	phosphoesterase, PA-phosphatase related
HLB41_RS14485	COG0604	alcohol dehydrogenase
HLB41_RS14550	COG2205	protein histidine kinase activity
HLB41_RS14575	COG1794	racemase activity, acting on amino acids and derivatives
HLB41_RS14580	COG1819	glycosyl
HLB41_RS14595	COG5002	protein histidine kinase activity
HLB41_RS14600	COG0561	phosphatase activity
HLB41_RS14645	COG2124	cytochrome p450
HLB41_RS14700	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLB41_RS14710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_RS14715	COG0460	homoserine dehydrogenase
HLB41_RS14735	COG0577	efflux transmembrane transporter activity
HLB41_RS14740	COG1136	(ABC) transporter
HLB41_RS14760	COG2205	protein histidine kinase activity
HLB41_RS14765	COG0745	RESPONSE REGULATOR receiver
HLB41_RS14775	COG3773	Cell wall hydrolase
HLB41_RS14780	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HLB41_RS14790	COG3386	PFAM SMP-30 Gluconolaconase
HLB41_RS14800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLB41_RS14805	COG2323	membrane
HLB41_RS14815	COG1063	alcohol dehydrogenase
HLB41_RS14840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_RS14890	COG1733	regulation of RNA biosynthetic process
HLB41_RS14895	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS14900	COG2814	Major facilitator Superfamily
HLB41_RS14910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLB41_RS14940	COG2207	Transcriptional regulator
HLB41_RS14945	COG3227	Zinc metalloprotease (Elastase)
HLB41_RS14960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLB41_RS14985	COG1686	Belongs to the peptidase S11 family
HLB41_RS15020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB41_RS15025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLB41_RS15030	COG1024	Enoyl-CoA hydratase
HLB41_RS15035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLB41_RS15040	COG0511	ligase activity, forming carbon-carbon bonds
HLB41_RS15045	COG0439	Biotin carboxylase
HLB41_RS15050	COG1960	acyl-CoA dehydrogenase activity
HLB41_RS15065	COG1309	transcriptional regulator
HLB41_RS15075	COG1131	(ABC) transporter
HLB41_RS15085	COG1408	metallophosphoesterase
HLB41_RS15100	COG0768	penicillin binding
HLB41_RS15110	COG1595	DNA-templated transcription, initiation
HLB41_RS15115	COG0768	penicillin binding
HLB41_RS15120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLB41_RS15155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS15160	COG0741	lytic transglycosylase activity
HLB41_RS15165	COG2312	Erythromycin esterase
HLB41_RS15200	COG2814	Major facilitator Superfamily
HLB41_RS15215	COG1686	Belongs to the peptidase S11 family
HLB41_RS15220	COG0110	maltose O-acetyltransferase activity
HLB41_RS15225	COG0730	response to heat
HLB41_RS15235	COG2002	toxin-antitoxin pair type II binding
HLB41_RS15260	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLB41_RS15290	COG1846	Transcriptional regulator
HLB41_RS15295	COG3961	Belongs to the TPP enzyme family
HLB41_RS15310	COG0500	methyltransferase
HLB41_RS15310	COG3615	Tellurite resistance protein tehB
HLB41_RS15330	COG1309	transcriptional regulator
HLB41_RS15350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_RS15370	COG1846	Transcriptional regulator
HLB41_RS15380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLB41_RS15390	COG2971	BadF BadG BcrA BcrD
HLB41_RS15415	COG1649	PFAM Uncharacterised BCR, COG1649
HLB41_RS15445	COG1595	DNA-templated transcription, initiation
HLB41_RS15450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB41_RS15480	COG1396	sequence-specific DNA binding
HLB41_RS15505	COG1132	(ABC) transporter
HLB41_RS15510	COG1132	(ABC) transporter
HLB41_RS15525	COG2258	MOSC domain
HLB41_RS15530	COG0583	DNA-binding transcription factor activity
HLB41_RS15550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLB41_RS15555	COG0583	DNA-binding transcription factor activity
HLB41_RS15585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS15620	COG1247	-acetyltransferase
HLB41_RS15650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_RS15670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB41_RS15710	COG1136	(ABC) transporter
HLB41_RS15715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLB41_RS15720	COG1187	pseudouridine synthase activity
HLB41_RS15740	COG1115	amino acid carrier protein
HLB41_RS15750	COG2318	DinB family
HLB41_RS15760	COG0776	regulation of translation
HLB41_RS15775	COG2814	Major facilitator Superfamily
HLB41_RS15780	COG3251	PFAM MbtH domain protein
HLB41_RS15785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLB41_RS15790	COG1535	isochorismatase
HLB41_RS15790	COG3433	isochorismatase activity
HLB41_RS15795	COG1021	2,3-dihydroxybenzoate-AMP ligase
HLB41_RS15800	COG1169	isochorismate synthase
HLB41_RS15805	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS15810	COG2223	nitrite transmembrane transporter activity
HLB41_RS15835	COG0419	ATPase involved in DNA repair
HLB41_RS15840	COG0420	3'-5' exonuclease activity
HLB41_RS15855	COG1024	Enoyl-CoA hydratase
HLB41_RS15860	COG1280	lysine exporter protein (LysE YggA)
HLB41_RS15870	COG2084	Dehydrogenase
HLB41_RS15875	COG1960	acyl-CoA dehydrogenase activity
HLB41_RS15880	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HLB41_RS15885	COG2079	MmgE PrpD family protein
HLB41_RS15890	COG0372	Belongs to the citrate synthase family
HLB41_RS15895	COG4841	protein insertion into membrane
HLB41_RS15900	COG2814	Major facilitator Superfamily
HLB41_RS15910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB41_RS15910	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLB41_RS15930	COG0300	oxidoreductase activity
HLB41_RS16020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_RS16025	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLB41_RS16030	COG0671	phosphoesterase, PA-phosphatase related
HLB41_RS16040	COG4991	sh3 domain protein
HLB41_RS16040	COG0515	serine threonine protein kinase
HLB41_RS16040	COG3064	Membrane
HLB41_RS16075	COG1509	lysine 2,3-aminomutase activity
HLB41_RS16080	COG3829	transcription factor binding
HLB41_RS16085	COG0456	acetyltransferase
HLB41_RS16090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB41_RS16095	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLB41_RS16100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLB41_RS16105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB41_RS16120	COG5506	Protein of unknown function (DUF1694)
HLB41_RS16125	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_RS16130	COG1253	flavin adenine dinucleotide binding
HLB41_RS16165	COG1174	glycine betaine transport
HLB41_RS16170	COG0517	IMP dehydrogenase activity
HLB41_RS16170	COG1125	glycine betaine transport
HLB41_RS16205	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HLB41_RS16230	COG1064	alcohol dehydrogenase
HLB41_RS16235	COG0384	phenazine biosynthesis protein PhzF
HLB41_RS16240	COG1737	Transcriptional regulator
HLB41_RS16245	COG2197	response regulator
HLB41_RS16250	COG4585	Histidine kinase
HLB41_RS16250	COG2203	Gaf domain
HLB41_RS16255	COG0668	transmembrane transport
HLB41_RS16265	COG1335	isochorismatase
HLB41_RS16285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLB41_RS16290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_RS16295	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_RS16310	COG0367	asparagine synthase
HLB41_RS16315	COG0071	Belongs to the small heat shock protein (HSP20) family
HLB41_RS16320	COG1999	signal sequence binding
HLB41_RS16330	COG1307	EDD domain protein, DegV family
HLB41_RS16340	COG0805	protein transport
HLB41_RS16350	COG1272	protein, Hemolysin III
HLB41_RS16355	COG0204	Acyl-transferase
HLB41_RS16365	COG0768	penicillin binding
HLB41_RS16380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLB41_RS16395	COG0546	phosphoglycolate phosphatase activity
HLB41_RS16405	COG4473	ABC transporter
HLB41_RS16410	COG1131	(ABC) transporter
HLB41_RS16420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HLB41_RS16425	COG3655	Transcriptional regulator
HLB41_RS16435	COG0456	acetyltransferase
HLB41_RS16445	COG1794	racemase activity, acting on amino acids and derivatives
HLB41_RS16455	COG2610	gluconate transmembrane transporter activity
HLB41_RS16480	COG0733	neurotransmitter:sodium symporter activity
HLB41_RS16495	COG3850	Histidine kinase
HLB41_RS16495	COG5002	protein histidine kinase activity
HLB41_RS16500	COG0745	RESPONSE REGULATOR receiver
HLB41_RS16510	COG1929	Belongs to the glycerate kinase type-1 family
HLB41_RS16515	COG0017	Asparaginyl-tRNA synthetase
HLB41_RS16555	COG0018	arginyl-trna synthetase
HLB41_RS16560	COG2136	Putative SAM-dependent methyltransferase
HLB41_RS16560	COG2521	methyltransferase
HLB41_RS16575	COG1413	lyase activity
HLB41_RS16580	COG0629	single-stranded DNA binding
HLB41_RS16595	COG0488	(ABC) transporter
HLB41_RS16600	COG1418	mRNA catabolic process
HLB41_RS16615	COG0457	Tetratricopeptide repeat
HLB41_RS16640	COG4974	Belongs to the 'phage' integrase family
HLB41_RS16670	COG2359	stage V sporulation protein S
HLB41_RS16705	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HLB41_RS16710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB41_RS16715	COG2146	nitrite reductase [NAD(P)H] activity
HLB41_RS16720	COG1587	Uroporphyrinogen-III synthase
HLB41_RS16720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLB41_RS16730	COG1648	precorrin-2 dehydrogenase activity
HLB41_RS16750	COG2223	nitrite transmembrane transporter activity
HLB41_RS16760	COG0314	molybdopterin synthase activity
HLB41_RS16765	COG0303	'Molybdopterin
HLB41_RS16770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLB41_RS16775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLB41_RS16780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB41_RS16785	COG2181	nitrate reductase activity
HLB41_RS16790	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HLB41_RS16795	COG1140	nitrate reductase beta subunit
HLB41_RS16800	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HLB41_RS16805	COG0714	Associated with various cellular activities
HLB41_RS16810	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HLB41_RS16815	COG1305	Transglutaminase-like
HLB41_RS16820	COG0386	Belongs to the glutathione peroxidase family
HLB41_RS16830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLB41_RS16830	COG0426	domain, Protein
HLB41_RS16840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLB41_RS16850	COG1595	DNA-templated transcription, initiation
HLB41_RS16855	COG0604	alcohol dehydrogenase
HLB41_RS16865	COG0346	lactoylglutathione lyase activity
HLB41_RS16890	COG2226	methyltransferase
HLB41_RS16915	COG3874	Sporulation protein YtfJ
HLB41_RS17035	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLB41_RS17070	COG0456	acetyltransferase
HLB41_RS17100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_RS17105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_RS17110	COG1819	glycosyl
HLB41_RS17125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLB41_RS17140	COG0561	phosphatase activity
HLB41_RS17150	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_RS17165	COG2211	Major facilitator Superfamily
HLB41_RS17170	COG0154	amidase activity
HLB41_RS17180	COG1876	peptidase activity
HLB41_RS17190	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_RS17210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLB41_RS17215	COG1114	Component of the transport system for branched-chain amino acids
HLB41_RS17230	COG1253	flavin adenine dinucleotide binding
HLB41_RS17235	COG2839	Protein conserved in bacteria
HLB41_RS17240	COG0702	epimerase
HLB41_RS17255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLB41_RS17265	COG1607	acyl-coa hydrolase
HLB41_RS17270	COG3689	TIGRFAM TIGR03943 family protein
HLB41_RS17275	COG0701	Predicted permease
HLB41_RS17285	COG2244	polysaccharide biosynthetic process
HLB41_RS17290	COG0586	Pfam SNARE associated Golgi protein
HLB41_RS17295	COG1051	belongs to the nudix hydrolase family
HLB41_RS17300	COG5337	Spore coat protein CotH
HLB41_RS17325	COG4166	transmembrane transport
HLB41_RS17335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLB41_RS17345	COG0702	epimerase
HLB41_RS17355	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLB41_RS17360	COG0456	acetyltransferase
HLB41_RS17365	COG0523	cobalamin synthesis protein
HLB41_RS17370	COG4989	oxidoreductase activity
HLB41_RS17375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS17380	COG1231	oxidoreductase activity
HLB41_RS17390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB41_RS17405	COG0783	Belongs to the Dps family
HLB41_RS17410	COG3949	Membrane
HLB41_RS17425	COG0840	transmembrane signaling receptor activity
HLB41_RS17450	COG3152	Membrane
HLB41_RS17455	COG2814	Major facilitator Superfamily
HLB41_RS17460	COG0667	Aldo Keto reductase
HLB41_RS17465	COG0640	Transcriptional regulator
HLB41_RS17470	COG1404	Belongs to the peptidase S8 family
HLB41_RS17475	COG2002	toxin-antitoxin pair type II binding
HLB41_RS17480	COG0577	efflux transmembrane transporter activity
HLB41_RS17515	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLB41_RS17525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_RS17530	COG1279	arginine transmembrane transporter activity
HLB41_RS17535	COG2814	Major facilitator Superfamily
HLB41_RS17545	COG1082	Xylose isomerase domain protein TIM barrel
HLB41_RS17560	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_RS17565	COG4264	IucA IucC family
HLB41_RS17575	COG1247	-acetyltransferase
HLB41_RS17580	COG1285	pathogenesis
HLB41_RS17595	COG5002	protein histidine kinase activity
HLB41_RS17600	COG0745	RESPONSE REGULATOR receiver
HLB41_RS17610	COG1316	TRANSCRIPTIONal
HLB41_RS17635	COG0460	homoserine dehydrogenase
HLB41_RS17665	COG0300	oxidoreductase activity
HLB41_RS17675	COG5002	protein histidine kinase activity
HLB41_RS17680	COG0745	RESPONSE REGULATOR receiver
HLB41_RS17685	COG1132	(ABC) transporter
HLB41_RS17695	COG0791	NLP P60 protein
HLB41_RS17695	COG1388	LysM domain
HLB41_RS17710	COG1686	Belongs to the peptidase S11 family
HLB41_RS17750	COG1216	Glycosyl transferase, family 2
HLB41_RS17760	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HLB41_RS17765	COG4988	ABC transporter
HLB41_RS17770	COG1294	oxidase, subunit
HLB41_RS17775	COG1271	oxidase subunit
HLB41_RS17805	COG0583	DNA-binding transcription factor activity
HLB41_RS17825	COG0411	ABC transporter
HLB41_RS17835	COG0523	cobalamin synthesis protein
HLB41_RS17840	COG1231	oxidoreductase activity
HLB41_RS17850	COG0628	permease
HLB41_RS17860	COG0778	Nitroreductase
HLB41_RS17865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HLB41_RS17870	COG1959	2 iron, 2 sulfur cluster binding
HLB41_RS17875	COG0583	DNA-binding transcription factor activity
HLB41_RS17880	COG0697	spore germination
HLB41_RS17885	COG4549	nuclear export factor GLE1
HLB41_RS17890	COG2372	response to copper ion
HLB41_RS17890	COG1276	copper resistance
HLB41_RS17900	COG1114	Component of the transport system for branched-chain amino acids
HLB41_RS17930	COG2132	Multicopper oxidase
HLB41_RS17940	COG0006	proline dipeptidase activity
HLB41_RS17950	COG4846	Membrane protein involved in cytochrome C biogenesis
HLB41_RS17960	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HLB41_RS17965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_RS17975	COG2390	Transcriptional regulator
HLB41_RS17980	COG1309	transcriptional regulator
HLB41_RS17995	COG0456	acetyltransferase
HLB41_RS18010	COG2309	aminopeptidase activity
HLB41_RS18040	COG0531	amino acid
HLB41_RS18045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLB41_RS18060	COG1914	H( )-stimulated, divalent metal cation uptake system
HLB41_RS18080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS18105	COG4166	transmembrane transport
HLB41_RS18125	COG0427	acetyl-CoA hydrolase
HLB41_RS18130	COG3279	Response regulator of the LytR AlgR family
HLB41_RS18140	COG3384	dioxygenase
HLB41_RS18145	COG2814	Major facilitator Superfamily
HLB41_RS18170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLB41_RS18190	COG0028	Belongs to the TPP enzyme family
HLB41_RS18195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLB41_RS18205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLB41_RS18225	COG2323	membrane
HLB41_RS18230	COG5566	PFAM Mor transcription activator
HLB41_RS18240	COG0733	neurotransmitter:sodium symporter activity
HLB41_RS18260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLB41_RS18265	COG2223	nitrite transmembrane transporter activity
HLB41_RS18270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLB41_RS18285	COG0477	Major facilitator Superfamily
HLB41_RS18295	COG1695	Transcriptional regulator
HLB41_RS18310	COG2814	Major facilitator Superfamily
HLB41_RS18355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLB41_RS18360	COG0784	Response regulator, receiver
HLB41_RS18365	COG4191	Histidine kinase
HLB41_RS18370	COG0281	malic enzyme
HLB41_RS18375	COG1027	Aspartate ammonia-lyase
HLB41_RS18390	COG0528	UMP kinase activity
HLB41_RS18395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLB41_RS18410	COG1131	(ABC) transporter
HLB41_RS18445	COG2733	membrane
HLB41_RS18465	COG0457	Tetratricopeptide repeat
HLB41_RS18480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_RS18485	COG0785	Cytochrome C biogenesis protein
HLB41_RS18505	COG3340	Belongs to the peptidase S51 family
HLB41_RS18510	COG0534	Mate efflux family protein
HLB41_RS18535	COG0789	Transcriptional regulator
HLB41_RS18540	COG1757	Na H antiporter
HLB41_RS18555	COG0701	Predicted permease
HLB41_RS18560	COG0523	cobalamin synthesis protein
HLB41_RS18570	COG0697	spore germination
HLB41_RS18575	COG1802	Transcriptional regulator
HLB41_RS18605	COG0367	asparagine synthase
HLB41_RS18635	COG0406	alpha-ribazole phosphatase activity
HLB41_RS18675	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLB41_RS18685	COG0583	DNA-binding transcription factor activity
HLB41_RS18710	COG2329	Antibiotic biosynthesis monooxygenase
HLB41_RS18745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLB41_RS18750	COG4786	Flagellar basal body rod
HLB41_RS18755	COG1419	protein localization to endoplasmic reticulum
HLB41_RS18760	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLB41_RS18765	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLB41_RS18775	COG1987	bacterial-type flagellum assembly
HLB41_RS18780	COG1338	Plays a role in the flagellum-specific transport system
HLB41_RS18790	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLB41_RS18790	COG1776	CheC inhibitor of MCP methylation
HLB41_RS18795	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLB41_RS18805	COG0741	lytic transglycosylase activity
HLB41_RS18815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLB41_RS18825	COG0835	chemotaxis
HLB41_RS18825	COG0784	Response regulator, receiver
HLB41_RS18840	COG1749	Flagellar hook protein flgE
HLB41_RS18860	COG1157	protein secretion by the type III secretion system
HLB41_RS18870	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLB41_RS18875	COG1766	The M ring may be actively involved in energy transduction
HLB41_RS18885	COG1558	bacterial-type flagellum-dependent cell motility
HLB41_RS18890	COG1815	bacterial-type flagellum-dependent cell motility
HLB41_RS18910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLB41_RS18915	COG1256	bacterial-type flagellum assembly
HLB41_RS18935	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLB41_RS18950	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLB41_RS18950	COG1776	CheC inhibitor of MCP methylation
HLB41_RS18955	COG2198	Histidine kinase
HLB41_RS18955	COG0643	Histidine kinase
HLB41_RS18960	COG2201	protein-glutamate methylesterase activity
HLB41_RS18965	COG1360	Flagellar Motor Protein
HLB41_RS18970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HLB41_RS18980	COG1923	regulation of RNA biosynthetic process
HLB41_RS19015	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HLB41_RS19020	COG2323	membrane
HLB41_RS19030	COG0789	Transcriptional regulator
HLB41_RS19030	COG4978	Transcriptional regulator
HLB41_RS19035	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLB41_RS19040	COG0475	glutathione-regulated potassium exporter activity
HLB41_RS19050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB41_RS19055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB41_RS19075	COG1280	lysine exporter protein (LysE YggA)
HLB41_RS19080	COG3403	YqcI/YcgG family
HLB41_RS19115	COG0328	RNA-DNA hybrid ribonuclease activity
HLB41_RS19135	COG0454	-acetyltransferase
HLB41_RS19150	COG0438	transferase activity, transferring glycosyl groups
HLB41_RS19155	COG1215	transferase activity, transferring glycosyl groups
HLB41_RS19170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLB41_RS19180	COG3944	biosynthesis protein
HLB41_RS19195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLB41_RS19245	COG0456	acetyltransferase
HLB41_RS19255	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLB41_RS19260	COG2311	Membrane
HLB41_RS19265	COG2233	PERMEase
HLB41_RS19275	COG0024	Methionine aminopeptidase
HLB41_RS19285	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HLB41_RS19290	COG1199	ATP-dependent helicase activity
HLB41_RS19300	COG0116	Belongs to the methyltransferase superfamily
HLB41_RS19355	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLB41_RS19355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB41_RS19365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLB41_RS19370	COG3935	DnaD domain protein
HLB41_RS19390	COG1199	ATP-dependent helicase activity
HLB41_RS19390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLB41_RS19425	COG0438	transferase activity, transferring glycosyl groups
HLB41_RS19445	COG1694	Mazg nucleotide pyrophosphohydrolase
HLB41_RS19450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_RS19460	COG2738	Putative neutral zinc metallopeptidase
HLB41_RS19475	COG4347	Protein of unknown function (DUF1405)
HLB41_RS19480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HLB41_RS19480	COG2010	Cytochrome c
HLB41_RS19485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HLB41_RS19505	COG0457	Tetratricopeptide repeat
HLB41_RS19530	COG0142	geranyltranstransferase activity
HLB41_RS19540	COG0142	geranyltranstransferase activity
HLB41_RS19555	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLB41_RS19625	COG0252	asparaginase activity
HLB41_RS19630	COG0492	ferredoxin-NADP+ reductase activity
HLB41_RS19650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLB41_RS19660	COG0789	Transcriptional regulator
HLB41_RS19665	COG1408	metallophosphoesterase
HLB41_RS19675	COG1266	CAAX protease self-immunity
HLB41_RS19680	COG0514	ATP-dependent DNA helicase (RecQ)
HLB41_RS19690	COG1141	Ferredoxin
HLB41_RS19695	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HLB41_RS19710	COG2096	Adenosyltransferase
HLB41_RS19715	COG5002	protein histidine kinase activity
HLB41_RS19720	COG0745	RESPONSE REGULATOR receiver
HLB41_RS19725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLB41_RS19730	COG1333	cytochrome c biogenesis protein
HLB41_RS19740	COG1187	pseudouridine synthase activity
HLB41_RS19745	COG0700	Nucleoside recognition
HLB41_RS19750	COG2715	membrane protein required for spore maturation
HLB41_RS19755	COG1686	Belongs to the peptidase S11 family
HLB41_RS19760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLB41_RS19775	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HLB41_RS19775	COG0392	lysyltransferase activity
HLB41_RS19790	COG5002	protein histidine kinase activity
HLB41_RS19795	COG0582	viral genome integration into host DNA
HLB41_RS19805	COG1801	Protein of unknown function DUF72
HLB41_RS19810	COG3852	Histidine kinase
HLB41_RS19825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB41_RS19830	COG1392	Phosphate transport regulator
HLB41_RS19835	COG0306	phosphate transporter
HLB41_RS19840	COG0730	response to heat
HLB41_RS19890	COG1114	Component of the transport system for branched-chain amino acids
HLB41_RS19900	COG2197	response regulator
HLB41_RS19905	COG4585	Histidine kinase
HLB41_RS19910	COG4758	membrane
HLB41_RS19925	COG1757	Na H antiporter
HLB41_RS19950	COG0733	neurotransmitter:sodium symporter activity
HLB41_RS19955	COG1648	precorrin-2 dehydrogenase activity
HLB41_RS19975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB41_RS19980	COG0529	Catalyzes the synthesis of activated sulfate
HLB41_RS20000	COG0019	diaminopimelate decarboxylase activity
HLB41_RS20010	COG1368	sulfuric ester hydrolase activity
HLB41_RS20015	COG1183	phosphatidylcholine synthase activity
HLB41_RS20030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLB41_RS20105	COG0440	acetolactate synthase activity
HLB41_RS20110	COG0028	Belongs to the TPP enzyme family
HLB41_RS20115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLB41_RS20135	COG3874	Sporulation protein YtfJ
HLB41_RS20140	COG4709	membrane
HLB41_RS20145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLB41_RS20150	COG1301	dicarboxylic acid transport
HLB41_RS20160	COG1846	Transcriptional regulator
HLB41_RS20200	COG3173	Aminoglycoside phosphotransferase
HLB41_RS20215	COG0716	FMN binding
HLB41_RS20235	COG1696	Membrane protein involved in D-alanine export
HLB41_RS20245	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HLB41_RS20250	COG2070	2-Nitropropane dioxygenase
HLB41_RS20255	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLB41_RS20265	COG1335	isochorismatase
HLB41_RS20275	COG1522	sequence-specific DNA binding
HLB41_RS20295	COG1131	(ABC) transporter
HLB41_RS20305	COG1131	(ABC) transporter
HLB41_RS20310	COG1725	Transcriptional regulator
HLB41_RS20315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLB41_RS20320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLB41_RS20325	COG1780	Probably involved in ribonucleotide reductase function
HLB41_RS20350	COG4873	Protein conserved in bacteria
HLB41_RS20365	COG0720	synthase
HLB41_RS20375	COG5002	protein histidine kinase activity
HLB41_RS20380	COG2318	DinB family
HLB41_RS20390	COG1846	Transcriptional regulator
HLB41_RS20395	COG3852	Histidine kinase
HLB41_RS20405	COG2861	carbohydrate metabolic process
HLB41_RS20415	COG0235	Class ii aldolase
HLB41_RS20425	COG1349	DNA-binding transcription factor activity
HLB41_RS20450	COG3842	ATPase activity
HLB41_RS20455	COG1840	ABC-type Fe3 transport system, periplasmic component
HLB41_RS20470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLB41_RS20480	COG3243	poly(R)-hydroxyalkanoic acid synthase
HLB41_RS20485	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS20505	COG2030	dehydratase
HLB41_RS20515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLB41_RS20520	COG0861	Integral membrane protein TerC family
HLB41_RS20525	COG2116	formate transmembrane transporter activity
HLB41_RS20535	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HLB41_RS20555	COG2186	Transcriptional regulator
HLB41_RS20560	COG5002	protein histidine kinase activity
HLB41_RS20565	COG0745	RESPONSE REGULATOR receiver
HLB41_RS20575	COG3835	regulator
HLB41_RS20580	COG0277	FAD linked oxidase domain protein
HLB41_RS20585	COG0247	lactate metabolic process
HLB41_RS20590	COG2340	Cysteine-rich secretory protein family
HLB41_RS20600	COG0564	pseudouridine synthase activity
HLB41_RS20610	COG2409	Drug exporters of the RND superfamily
HLB41_RS20625	COG1177	transmembrane transport
HLB41_RS20630	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLB41_RS20640	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_RS20675	COG0681	Belongs to the peptidase S26 family
HLB41_RS20680	COG1686	Belongs to the peptidase S11 family
HLB41_RS20710	COG1668	transmembrane transport
HLB41_RS20715	COG4152	abc transporter atp-binding protein
HLB41_RS20730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB41_RS20780	COG1476	TRANSCRIPTIONal
HLB41_RS20790	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLB41_RS20840	COG5634	Uncharacterized conserved protein (DUF2278)
HLB41_RS20845	COG1620	l-lactate permease
HLB41_RS20880	COG0512	Glutamine amidotransferase of anthranilate synthase
HLB41_RS20880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLB41_RS20890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB41_RS20910	COG2382	esterase
HLB41_RS20920	COG2153	protein acetylation
HLB41_RS20965	COG1091	dTDP-4-dehydrorhamnose reductase activity
HLB41_RS20980	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HLB41_RS21000	COG0463	Glycosyl transferase, family 2
HLB41_RS21000	COG0457	Tetratricopeptide repeat
HLB41_RS21020	COG1216	Glycosyl transferase, family 2
HLB41_RS21025	COG0772	Belongs to the SEDS family
HLB41_RS21040	COG0564	pseudouridine synthase activity
HLB41_RS21050	COG2357	RelA SpoT domain protein
HLB41_RS21060	COG4116	CYTH
HLB41_RS21065	COG2346	COG2346, Truncated hemoglobins
HLB41_RS21080	COG1164	Oligoendopeptidase f
HLB41_RS21100	COG0861	Integral membrane protein TerC family
HLB41_RS21115	COG4166	transmembrane transport
HLB41_RS21120	COG0534	Mate efflux family protein
HLB41_RS21125	COG4608	Belongs to the ABC transporter superfamily
HLB41_RS21130	COG0444	Belongs to the ABC transporter superfamily
HLB41_RS21135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB41_RS21140	COG0601	transmembrane transport
HLB41_RS21145	COG4166	transmembrane transport
HLB41_RS21155	COG0180	Tryptophanyl-tRNA synthetase
HLB41_RS21165	COG5504	Zn-dependent protease
HLB41_RS21170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLB41_RS21190	COG2267	carboxylic ester hydrolase activity
HLB41_RS21210	COG0561	phosphatase activity
HLB41_RS21225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_RS21295	COG2996	Protein conserved in bacteria
HLB41_RS21315	COG0004	ammonium transporteR
HLB41_RS21320	COG0753	catalase activity
HLB41_RS21330	COG0367	asparagine synthase
HLB41_RS21355	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLB41_RS21415	COG0398	Pfam SNARE associated Golgi protein
HLB41_RS21455	COG2224	Isocitrate lyase
HLB41_RS21460	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HLB41_RS21470	COG3693	PFAM glycoside hydrolase, family 10
HLB41_RS21475	COG0840	transmembrane signaling receptor activity
HLB41_RS21480	COG0501	Belongs to the peptidase M48B family
HLB41_RS21500	COG0745	RESPONSE REGULATOR receiver
HLB41_RS21505	COG2205	protein histidine kinase activity
HLB41_RS21510	COG2207	Transcriptional regulator
HLB41_RS21510	COG3708	Transcriptional regulator
HLB41_RS21515	COG1595	DNA-templated transcription, initiation
HLB41_RS21525	COG1078	dGTPase activity
HLB41_RS21530	COG1408	metallophosphoesterase
HLB41_RS21535	COG1073	alpha beta
HLB41_RS21695	COG4208	sulfate ABC transporter
HLB41_RS21705	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HLB41_RS21715	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_RS21725	COG0095	Lipoate-protein ligase
HLB41_RS21730	COG1234	tRNA 3'-trailer cleavage
HLB41_RS21740	COG1609	Transcriptional regulator
HLB41_RS21745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS21765	COG1511	domain protein
HLB41_RS21770	COG1309	transcriptional regulator
HLB41_RS21820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB41_RS21825	COG2329	Antibiotic biosynthesis monooxygenase
HLB41_RS21830	COG3428	Bacterial PH domain
HLB41_RS21835	COG3402	PFAM membrane-flanked domain
HLB41_RS21840	COG0697	spore germination
HLB41_RS21870	COG3428	Bacterial PH domain
HLB41_RS21875	COG3402	PFAM membrane-flanked domain
HLB41_RS21900	COG4473	ABC transporter
HLB41_RS21905	COG1131	(ABC) transporter
HLB41_RS21910	COG0537	adenosine 5'-monophosphoramidase activity
HLB41_RS21915	COG4980	gas vesicle protein
HLB41_RS21935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLB41_RS21945	COG3973	AAA domain
HLB41_RS21960	COG1595	DNA-templated transcription, initiation
HLB41_RS21975	COG1695	Transcriptional regulator
HLB41_RS21980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLB41_RS21990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLB41_RS21995	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HLB41_RS22000	COG3620	sequence-specific DNA binding
HLB41_RS22005	COG2140	Oxalate decarboxylase
HLB41_RS22030	COG2267	carboxylic ester hydrolase activity
HLB41_RS22040	COG0457	Tetratricopeptide repeat
HLB41_RS22045	COG0346	lactoylglutathione lyase activity
HLB41_RS22050	COG0346	lactoylglutathione lyase activity
HLB41_RS22060	COG4717	serine-type aminopeptidase activity
HLB41_RS22065	COG0420	3'-5' exonuclease activity
HLB41_RS22085	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HLB41_RS22130	COG0784	Response regulator, receiver
HLB41_RS22130	COG5002	protein histidine kinase activity
HLB41_RS22130	COG2205	protein histidine kinase activity
HLB41_RS22135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLB41_RS22140	COG2208	phosphoserine phosphatase activity
HLB41_RS22150	COG1191	sigma factor activity
HLB41_RS22220	COG0596	Alpha beta hydrolase
HLB41_RS22240	COG2373	Large extracellular alpha-helical protein
HLB41_RS22250	COG0791	NLP P60 protein
HLB41_RS22250	COG1388	LysM domain
HLB41_RS22255	COG3584	3D domain protein
HLB41_RS22255	COG1388	LysM domain
HLB41_RS22295	COG2376	Dihydroxyacetone kinase
HLB41_RS22305	COG2376	Dihydroxyacetone kinase
HLB41_RS22320	COG1183	phosphatidylcholine synthase activity
HLB41_RS22360	COG1073	alpha beta
HLB41_RS22380	COG3344	reverse transcriptase
HLB41_RS22385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_RS22400	COG0477	Major facilitator Superfamily
HLB41_RS22425	COG0305	Participates in initiation and elongation during chromosome replication
HLB41_RS22460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HLB41_RS22475	COG0494	nUDIX hydrolase
HLB41_RS22480	COG3181	Tripartite tricarboxylate transporter family receptor
HLB41_RS22485	COG4565	transcriptional regulatory protein
HLB41_RS22490	COG3290	protein histidine kinase activity
HLB41_RS22495	COG0477	Major facilitator Superfamily
HLB41_RS22720	COG0457	Tetratricopeptide repeat
HLB41_RS22740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_RS22750	COG4608	Belongs to the ABC transporter superfamily
HLB41_RS22755	COG0444	Belongs to the ABC transporter superfamily
HLB41_RS22760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB41_RS22765	COG0601	transmembrane transport
HLB41_RS22800	COG1363	Peptidase, m42
HLB41_RS22820	COG1024	Enoyl-CoA hydratase
HLB41_RS22840	COG2244	polysaccharide biosynthetic process
HLB41_RS22845	COG0659	secondary active sulfate transmembrane transporter activity
HLB41_RS22860	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_RS22865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLB41_RS22870	COG5632	N-Acetylmuramoyl-L-alanine amidase
HLB41_RS22870	COG3409	Peptidoglycan-binding domain 1 protein
HLB41_RS22880	COG0561	phosphatase activity
HLB41_RS22890	COG3527	Alpha-acetolactate decarboxylase
HLB41_RS22895	COG0028	Belongs to the TPP enzyme family
HLB41_RS22900	COG2197	response regulator
HLB41_RS22905	COG4585	Histidine kinase
HLB41_RS22925	COG0189	ligase activity
HLB41_RS22940	COG1126	abc transporter atp-binding protein
HLB41_RS22945	COG0765	amino acid transport
HLB41_RS22950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB41_RS22955	COG1132	(ABC) transporter
HLB41_RS22960	COG1132	(ABC) transporter
HLB41_RS22965	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_RS22975	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLB41_RS22980	COG0531	amino acid
HLB41_RS22990	COG0753	catalase activity
HLB41_RS22990	COG0693	protein deglycase activity
HLB41_RS22995	COG0693	protein deglycase activity
HLB41_RS23010	COG2211	Major facilitator Superfamily
HLB41_RS23015	COG4533	DNA binding
HLB41_RS23020	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLB41_RS23030	COG1733	regulation of RNA biosynthetic process
HLB41_RS23035	COG2814	Major facilitator Superfamily
HLB41_RS23040	COG1309	transcriptional regulator
HLB41_RS23060	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS23065	COG0165	Argininosuccinate lyase
HLB41_RS23065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HLB41_RS23070	COG1522	sequence-specific DNA binding
HLB41_RS23090	COG2259	Doxx family
HLB41_RS23100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_RS23100	COG1263	PTS System
HLB41_RS23110	COG1737	Transcriptional regulator
HLB41_RS23120	COG0475	glutathione-regulated potassium exporter activity
HLB41_RS23125	COG0531	amino acid
HLB41_RS23160	COG0586	Pfam SNARE associated Golgi protein
HLB41_RS23195	COG3546	catalase activity
HLB41_RS23200	COG1114	Component of the transport system for branched-chain amino acids
HLB41_RS23215	COG5522	Integral membrane protein (intg_mem_TP0381)
HLB41_RS23225	COG1136	(ABC) transporter
HLB41_RS23230	COG0577	efflux transmembrane transporter activity
HLB41_RS23235	COG3584	3D domain protein
HLB41_RS23235	COG1388	LysM domain
HLB41_RS23255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLB41_RS23260	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLB41_RS23265	COG3711	transcriptional antiterminator
HLB41_RS23265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB41_RS23280	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLB41_RS23285	COG0604	alcohol dehydrogenase
HLB41_RS23290	COG1316	TRANSCRIPTIONal
HLB41_RS23300	COG0730	response to heat
HLB41_RS23305	COG2210	Belongs to the sulfur carrier protein TusA family
HLB41_RS23310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_RS23315	COG0425	Belongs to the sulfur carrier protein TusA family
HLB41_RS23315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_RS23320	COG0425	Belongs to the sulfur carrier protein TusA family
HLB41_RS23325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_RS23325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_RS23330	COG0425	Belongs to the sulfur carrier protein TusA family
HLB41_RS23330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_RS23335	COG1937	Protein conserved in bacteria
HLB41_RS23340	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLB41_RS23355	COG1414	Transcriptional regulator
HLB41_RS23365	COG2719	SpoVR family
HLB41_RS23370	COG0778	Nitroreductase
HLB41_RS23420	COG1609	Transcriptional regulator
HLB41_RS23425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_RS23425	COG1263	PTS System
HLB41_RS23430	COG1621	beta-fructofuranosidase activity
HLB41_RS23435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLB41_RS23450	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS23455	COG2252	PERMEase
HLB41_RS23465	COG1129	ABC transporter
HLB41_RS23470	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB41_RS23485	COG1136	(ABC) transporter
HLB41_RS23510	COG1846	Transcriptional regulator
HLB41_RS23515	COG2814	Major facilitator Superfamily
HLB41_RS23520	COG2205	protein histidine kinase activity
HLB41_RS23560	COG0351	phosphomethylpyrimidine kinase
HLB41_RS23565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLB41_RS23575	COG2104	thiamine diphosphate biosynthetic process
HLB41_RS23580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB41_RS23585	COG0352	thiamine-phosphate diphosphorylase activity
HLB41_RS23590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB41_RS23595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB41_RS23600	COG1116	anion transmembrane transporter activity
HLB41_RS23605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLB41_RS23625	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HLB41_RS23745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB41_RS23755	COG0581	inorganic phosphate transmembrane transporter activity
HLB41_RS23760	COG0573	inorganic phosphate transmembrane transporter activity
HLB41_RS23765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLB41_RS23770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HLB41_RS23770	COG1918	ferrous iron import across plasma membrane
HLB41_RS23775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HLB41_RS23780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HLB41_RS23790	COG0531	amino acid
HLB41_RS23795	COG0697	spore germination
HLB41_RS23800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB41_RS23815	COG4990	cell redox homeostasis
HLB41_RS23820	COG0833	amino acid
HLB41_RS23830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLB41_RS23845	COG0475	glutathione-regulated potassium exporter activity
HLB41_RS23845	COG0569	domain protein
HLB41_RS23855	COG2153	protein acetylation
HLB41_RS23870	COG2252	PERMEase
HLB41_RS23875	COG1113	amino acid transport
HLB41_RS23890	COG1114	Component of the transport system for branched-chain amino acids
HLB41_RS23895	COG3104	oligopeptide transport
HLB41_RS23915	COG1476	TRANSCRIPTIONal
HLB41_RS23920	COG3584	3D domain protein
HLB41_RS23920	COG1388	LysM domain
HLB41_RS23925	COG0840	transmembrane signaling receptor activity
HLB41_RS23975	COG1063	alcohol dehydrogenase
HLB41_RS23995	COG1879	ABC-type sugar transport system periplasmic component
HLB41_RS24000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB41_RS24015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLB41_RS24020	COG1609	Transcriptional regulator
HLB41_RS24025	COG0477	Major facilitator Superfamily
HLB41_RS24030	COG1846	Transcriptional regulator
HLB41_RS24035	COG2271	Major facilitator Superfamily
HLB41_RS24050	COG0659	secondary active sulfate transmembrane transporter activity
HLB41_RS24075	COG5002	protein histidine kinase activity
HLB41_RS24080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLB41_RS24085	COG2378	regulation of single-species biofilm formation
HLB41_RS24110	COG0833	amino acid
HLB41_RS24115	COG0765	amino acid transport
HLB41_RS24120	COG0765	amino acid transport
HLB41_RS24125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB41_RS24130	COG1126	abc transporter atp-binding protein
HLB41_RS24135	COG1115	amino acid carrier protein
HLB41_RS24140	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLB41_RS24150	COG0697	spore germination
HLB41_RS24165	COG0366	Alpha amylase catalytic
HLB41_RS24170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_RS24170	COG1263	PTS System
HLB41_RS24175	COG2188	Transcriptional regulator
HLB41_RS24180	COG0531	amino acid
HLB41_RS24200	COG0714	Associated with various cellular activities
HLB41_RS24205	COG4548	von Willebrand factor, type A
HLB41_RS24215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB41_RS24235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_RS24240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_RS24245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_RS24250	COG3104	oligopeptide transport
HLB41_RS24265	COG1620	l-lactate permease
HLB41_RS24270	COG1027	Aspartate ammonia-lyase
HLB41_RS24275	COG1253	flavin adenine dinucleotide binding
HLB41_RS24280	COG0346	lactoylglutathione lyase activity
HLB41_RS24285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_RS24290	COG1316	TRANSCRIPTIONal
HLB41_RS24295	COG2720	vancomycin resistance protein
HLB41_RS24315	COG3227	Zinc metalloprotease (Elastase)
HLB41_RS24335	COG2217	Heavy metal translocating P-type atpase
HLB41_RS24340	COG0640	Transcriptional regulator
HLB41_RS24345	COG0531	amino acid
HLB41_RS24360	COG2427	Protein of unknown function (DUF1641)
HLB41_RS24365	COG3383	formate dehydrogenase (NAD+) activity
HLB41_RS24370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLB41_RS24385	COG5002	protein histidine kinase activity
HLB41_RS24395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_RS24400	COG0697	spore germination
HLB41_RS24410	COG0281	malic enzyme
HLB41_RS24415	COG3493	citrate carrier protein
HLB41_RS24420	COG4565	transcriptional regulatory protein
HLB41_RS24425	COG3290	protein histidine kinase activity
HLB41_RS24435	COG4990	cell redox homeostasis
HLB41_RS24445	COG5002	protein histidine kinase activity
HLB41_RS24450	COG0745	RESPONSE REGULATOR receiver
HLB41_RS24455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLB41_RS24465	COG0395	ABC-type sugar transport system, permease component
HLB41_RS24470	COG1175	transmembrane transport
HLB41_RS24475	COG3842	ATPase activity
HLB41_RS24480	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HLB41_RS24505	COG2851	Citrate transporter
HLB41_RS24510	COG4565	transcriptional regulatory protein
HLB41_RS24515	COG3290	protein histidine kinase activity
HLB41_RS24525	COG2268	Band 7 protein
HLB41_RS24530	COG1585	Membrane protein implicated in regulation of membrane protease activity
HLB41_RS24540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB41_RS24560	COG2766	serine protein kinase
HLB41_RS24570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HLB41_RS24595	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HLB41_RS24715	COG0735	belongs to the Fur family
HLB41_RS24720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLB41_RS24740	COG4555	ABC transporter
HLB41_RS24750	COG0067	glutamate synthase
HLB41_RS24750	COG0069	glutamate synthase activity
HLB41_RS24750	COG0070	glutamate synthase
HLB41_RS24755	COG4129	membrane
HLB41_RS24760	COG1132	(ABC) transporter
HLB41_RS24785	COG1194	a g-specific adenine glycosylase
HLB41_RS24790	COG1988	membrane-bound metal-dependent
HLB41_RS24820	COG1090	epimerase
HLB41_RS24825	COG1228	amidohydrolase
HLB41_RS24845	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLB41_RS24865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLB41_RS24865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB41_RS24875	COG0463	Glycosyl transferase, family 2
HLB41_RS24890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLB41_RS24895	COG1263	PTS System
HLB41_RS24895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_RS24925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB41_RS24930	COG0833	amino acid
HLB41_RS24940	COG3829	transcription factor binding
HLB41_RS24955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLB41_RS24960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HLB41_RS24980	COG0535	radical SAM domain protein
HLB41_RS24990	COG0387	Pfam Sodium calcium exchanger
HLB41_RS24995	COG3871	stress protein (general stress protein 26)
HLB41_RS25010	COG0586	Pfam SNARE associated Golgi protein
HLB41_RS25020	COG0681	Belongs to the peptidase S26 family
HLB41_RS25030	COG0697	spore germination
HLB41_RS25035	COG2217	Heavy metal translocating P-type atpase
HLB41_RS25040	COG1295	ribonuclease BN
HLB41_RS25050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLB41_RS25065	COG3853	Toxic anion resistance protein (TelA)
HLB41_RS25075	COG0861	Integral membrane protein TerC family
HLB41_RS25080	COG2310	stress, protein
HLB41_RS25085	COG2310	stress, protein
HLB41_RS25090	COG2310	stress, protein
HLB41_RS25120	COG2270	Major facilitator Superfamily
HLB41_RS25170	COG1116	anion transmembrane transporter activity
HLB41_RS25175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB41_RS25180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB41_RS25200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HLB41_RS25230	COG2190	(PTS) system
HLB41_RS25230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_RS25230	COG1263	PTS System
HLB41_RS25235	COG0366	Alpha amylase catalytic
HLB41_RS25240	COG0277	FAD linked oxidase domain protein
HLB41_RS25250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB41_RS25255	COG0549	Belongs to the carbamate kinase family
HLB41_RS25280	COG0840	transmembrane signaling receptor activity
HLB41_RS25285	COG1126	abc transporter atp-binding protein
HLB41_RS25290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB41_RS25295	COG0765	amino acid transport
HLB41_RS25305	COG0723	plastoquinol--plastocyanin reductase activity
HLB41_RS25305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB41_RS25310	COG2814	Major facilitator Superfamily
HLB41_RS25315	COG3541	Predicted nucleotidyltransferase
HLB41_RS25335	COG5002	protein histidine kinase activity
HLB41_RS25360	COG0166	Belongs to the GPI family
HLB41_RS25370	COG0492	ferredoxin-NADP+ reductase activity
HLB41_RS25375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_RS25380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_RS25385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_RS25405	COG0450	alkyl hydroperoxide reductase
HLB41_RS25420	COG1473	amidohydrolase
HLB41_RS25450	COG4807	Protein conserved in bacteria
HLB41_RS25465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLB41_RS25475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_RS25495	COG2309	aminopeptidase activity
HLB41_RS25505	COG2076	Multidrug Resistance protein
HLB41_RS25510	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_RS25520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLB41_RS25530	COG1597	lipid kinase activity
HLB41_RS25550	COG4682	membrane
HLB41_RS25555	COG1846	Transcriptional regulator
HLB41_RS25560	COG0003	Pfam Anion-transporting ATPase
HLB41_RS25575	COG1464	Belongs to the NlpA lipoprotein family
HLB41_RS25580	COG2011	ABC-type metal ion transport system permease component
HLB41_RS25590	COG1335	isochorismatase
HLB41_RS25605	COG4851	CamS sex pheromone cAM373 precursor
HLB41_RS25615	COG0210	DNA helicase
HLB41_RS25640	COG0151	Belongs to the GarS family
HLB41_RS25650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLB41_RS25660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLB41_RS25675	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLB41_RS25685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLB41_RS25690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLB41_RS25695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLB41_RS25720	COG0697	spore germination
HLB41_RS25740	COG1215	transferase activity, transferring glycosyl groups
HLB41_RS25750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB41_RS25760	COG2226	methyltransferase
HLB41_RS25790	COG0745	RESPONSE REGULATOR receiver
HLB41_RS25795	COG2205	protein histidine kinase activity
HLB41_RS25835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HLB41_RS25860	COG5002	protein histidine kinase activity
HLB41_RS25870	COG2252	PERMEase
HLB41_RS25890	COG1266	CAAX protease self-immunity
HLB41_RS25905	COG0488	(ABC) transporter
HLB41_RS25915	COG0456	acetyltransferase
HLB41_RS25920	COG1214	PFAM Peptidase M22, glycoprotease
HLB41_RS25925	COG0802	atpase or kinase
HLB41_RS26025	COG2183	response to ionizing radiation
HLB41_RS26030	COG2337	Toxic component of a toxin-antitoxin (TA) module
HLB41_RS26035	COG0864	Transcriptional regulator
HLB41_RS26040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLB41_RS26045	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HLB41_RS26055	COG0705	Rhomboid family
HLB41_RS26060	COG4294	response to UV
HLB41_RS26070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLB41_RS26080	COG2814	Major facilitator Superfamily
HLB41_RS26085	COG0531	amino acid
HLB41_RS26095	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLB41_RS26100	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HLB41_RS26130	COG0561	phosphatase activity
HLB41_RS26135	COG4608	Belongs to the ABC transporter superfamily
HLB41_RS26140	COG0444	Belongs to the ABC transporter superfamily
HLB41_RS26150	COG0601	transmembrane transport
HLB41_RS26155	COG0747	negative chemotaxis
HLB41_RS26165	COG0488	(ABC) transporter
HLB41_RS26185	COG5298	Protein conserved in bacteria
HLB41_RS26200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_RS26210	COG1609	Transcriptional regulator
HLB41_RS26220	COG0204	Acyl-transferase
HLB41_RS26235	COG0697	spore germination
HLB41_RS26250	COG1910	domain protein
HLB41_RS26255	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLB41_RS26260	COG4149	molybdate abc transporter
HLB41_RS26280	COG0656	L-ascorbic acid biosynthetic process
HLB41_RS26285	COG4166	transmembrane transport
HLB41_RS26290	COG4166	transmembrane transport
HLB41_RS26305	COG2207	Transcriptional regulator
HLB41_RS26315	COG4166	transmembrane transport
HLB41_RS26320	COG4608	Belongs to the ABC transporter superfamily
HLB41_RS26325	COG0444	Belongs to the ABC transporter superfamily
HLB41_RS26330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB41_RS26335	COG0601	transmembrane transport
HLB41_RS26350	COG2814	Major facilitator Superfamily
HLB41_RS26360	COG2271	Major facilitator Superfamily
HLB41_RS26365	COG0277	FAD linked oxidase domain protein
HLB41_RS26375	COG0604	alcohol dehydrogenase
HLB41_RS26380	COG1464	Belongs to the NlpA lipoprotein family
HLB41_RS26385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLB41_RS26390	COG2011	ABC-type metal ion transport system permease component
HLB41_RS26395	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_RS26485	COG4856	YbbR-like protein
HLB41_RS26490	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HLB41_RS26570	COG0726	polysaccharide deacetylase
HLB41_RS26575	COG2194	sulfuric ester hydrolase activity
HLB41_RS26585	COG0489	protein tyrosine kinase activity
HLB41_RS26590	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_RS26615	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HLB41_RS26650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLB41_RS26660	COG0024	Methionine aminopeptidase
HLB41_RS26670	COG0201	protein transport
HLB41_RS26730	COG0255	Belongs to the universal ribosomal protein uL29 family
HLB41_RS26795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLB41_RS26800	COG1358	cellular component organization or biogenesis
HLB41_RS26815	COG2813	Specifically methylates the guanine in position
HLB41_RS26835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLB41_RS26840	COG0250	Participates in transcription elongation, termination and antitermination
HLB41_RS26845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLB41_RS26860	COG3688	RNA-binding protein containing a PIN domain
HLB41_RS26865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLB41_RS26880	COG1045	serine acetyltransferase
HLB41_RS26900	COG4956	integral membrane protein (PIN domain superfamily)
HLB41_RS26910	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLB41_RS26915	COG0542	response to heat
HLB41_RS26925	COG3880	PFAM UvrB UvrC protein
HLB41_RS27015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLB41_RS27020	COG1396	sequence-specific DNA binding
HLB41_RS27025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLB41_RS27030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HLB41_RS27035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLB41_RS27040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLB41_RS27045	COG0512	Glutamine amidotransferase of anthranilate synthase
HLB41_RS27050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLB41_RS27055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLB41_RS27070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLB41_RS27085	COG2208	phosphoserine phosphatase activity
HLB41_RS27100	COG1098	S1 RNA binding domain
HLB41_RS27120	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLB41_RS27125	COG3956	TIGRFAM MazG family protein
HLB41_RS27130	COG2244	polysaccharide biosynthetic process
HLB41_RS27135	COG2002	toxin-antitoxin pair type II binding
HLB41_RS27140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLB41_RS27170	COG0251	oxidation-reduction process
HLB41_RS27175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLB41_RS27190	COG2217	Heavy metal translocating P-type atpase
HLB41_RS27195	COG1937	Protein conserved in bacteria
HLB41_RS27200	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLB41_RS27200	COG3443	Belongs to the bacterial solute-binding protein 9 family
HLB41_RS27220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_RS27270	COG3118	belongs to the thioredoxin family
HLB41_RS27290	COG1126	abc transporter atp-binding protein
HLB41_RS27295	COG2304	oxidoreductase activity
HLB41_RS27300	COG2132	Multicopper oxidase
HLB41_RS27305	COG0745	RESPONSE REGULATOR receiver
HLB41_RS27310	COG5002	protein histidine kinase activity
HLB41_RS27320	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_RS27330	COG4974	Belongs to the 'phage' integrase family
HLB41_RS27345	COG0457	Tetratricopeptide repeat
HLB41_RS27465	COG3344	reverse transcriptase
HLB41_RS27485	COG3344	reverse transcriptase
HLB41_RS27535	COG1396	sequence-specific DNA binding
HLB41_RS27570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLB41_RS27575	COG0582	viral genome integration into host DNA
HLB41_RS27610	COG2003	Belongs to the UPF0758 family
HLB41_RS27685	COG3397	chitin binding
HLB41_RS27720	COG3103	Sh3 type 3 domain protein
HLB41_RS27720	COG0791	NLP P60 protein
HLB41_RS27720	COG1388	LysM domain
HLB41_RS27760	COG0640	Transcriptional regulator
HLB41_RS27885	COG3344	reverse transcriptase
HLB41_RS28025	COG3344	reverse transcriptase
HLB41_RS28135	COG4962	Type ii secretion system protein e
HLB41_RS28220	COG0640	Transcriptional regulator
HLB41_RS28235	COG2072	flavoprotein involved in K transport
HLB41_RS28245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLB41_RS28250	COG0589	response to stress
HLB41_RS28255	COG0659	secondary active sulfate transmembrane transporter activity
HLB41_RS28260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB41_RS28275	COG0659	secondary active sulfate transmembrane transporter activity
HLB41_RS28290	COG2824	Alkylphosphonate utilization operon protein PhnA
HLB41_RS28310	COG0640	Transcriptional regulator
HLB41_RS28315	COG0798	PFAM Bile acid sodium symporter
HLB41_RS28405	COG3344	reverse transcriptase
HLB41_RS28485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLB41_RS28500	COG1063	alcohol dehydrogenase
HLB41_RS28505	COG1733	regulation of RNA biosynthetic process
HLB41_RS28515	COG3791	Glutathione-dependent formaldehyde-activating
HLB41_RS28525	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HLB41_RS28535	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLB41_RS28540	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLB41_RS28540	COG2918	glutathione biosynthetic process
HLB41_RS28580	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLB41_RS28595	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLB41_RS28595	COG2918	glutathione biosynthetic process
HLB41_RS28635	COG2311	Membrane
HLB41_RS28705	COG2002	toxin-antitoxin pair type II binding
HLB41_RS28740	COG4974	Belongs to the 'phage' integrase family
HLB41_RS28765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLB41_RS28795	COG4166	transmembrane transport
HLB41_RS28810	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HLB41_RS28890	COG0789	Transcriptional regulator
HLB41_RS28940	COG1733	regulation of RNA biosynthetic process
HLB41_RS28950	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLB41_RS28960	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLB41_RS28960	COG2918	glutathione biosynthetic process
HLB41_RS28990	COG1335	isochorismatase
HLB41_RS28995	COG4990	cell redox homeostasis
HLB41_RS29000	COG0745	RESPONSE REGULATOR receiver
HLB41_RS29050	COG0798	PFAM Bile acid sodium symporter
HLB41_RS29055	COG0640	Transcriptional regulator
HLB41_RS29075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLB41_RS29085	COG3620	sequence-specific DNA binding
HLB41_RS29090	COG0306	phosphate transporter
HLB41_RS29095	COG0640	Transcriptional regulator
HLB41_RS29110	COG1846	Transcriptional regulator