locus-tag class description FOC77_RS00005 ENOG4105DWT malate dehydrogenase (quinone) FOC77_RS00010 ENOG4105D01 (LipO)protein FOC77_RS00015 ENOG4108UMI ABC transporter, permease FOC77_RS00020 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC77_RS00025 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC77_RS00030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC77_RS00040 ENOG4105X5K response regulator receiver protein FOC77_RS00045 ENOG4105DEN Luciferase family FOC77_RS00050 ENOG4105DEN Luciferase family FOC77_RS00060 ENOG4105BZU Histidine kinase FOC77_RS00080 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC77_RS00090 ENOG4106YBV Methyl-accepting chemotaxis FOC77_RS00095 ENOG4105CDA abc transporter atp-binding protein FOC77_RS00100 ENOG4105E5Q amino acid AbC transporter FOC77_RS00110 ENOG4108Y4K DNA-binding transcriptional activator FOC77_RS00115 ENOG4105D8G Major Facilitator superfamily FOC77_RS00125 ENOG4105C8J )-transporter FOC77_RS00130 ENOG4105C1J atp-dependent rna helicase FOC77_RS00135 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC77_RS00140 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) FOC77_RS00145 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC77_RS00150 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) FOC77_RS00160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC77_RS00165 ENOG4105BZU Histidine kinase FOC77_RS00170 ENOG4105EMU Dehydrogenase FOC77_RS00175 ENOG4105VUF Transcriptional regulator FOC77_RS00185 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC77_RS00200 ENOG4105CDA abc transporter atp-binding protein FOC77_RS00205 ENOG4105E5Q amino acid AbC transporter FOC77_RS00210 ENOG4105EAB amino acid AbC transporter FOC77_RS00225 ENOG4107Y9U Membrane FOC77_RS00255 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC77_RS00265 ENOG4108PCN EamA-like transporter family FOC77_RS00270 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC77_RS00360 ENOG4105W5Q DNA repair protein (RadC FOC77_RS00385 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FOC77_RS00395 ENOG4105C0H protease FOC77_RS00400 ENOG4105Q2H domain protein FOC77_RS00415 ENOG4105BZU Histidine kinase FOC77_RS00420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC77_RS00445 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOC77_RS00450 ENOG4105CDU Replicative dna helicase FOC77_RS00455 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FOC77_RS00460 ENOG4105BZR domain protein FOC77_RS00465 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FOC77_RS00470 ENOG4108UUM single-stranded DNA-binding protein FOC77_RS00475 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FOC77_RS00485 ENOG4105C3G gtp-binding protein FOC77_RS00490 ENOG4105VDK protein, conserved in bacteria FOC77_RS00495 ENOG4105D8X mechanosensitive ion channel FOC77_RS00500 ENOG4108ZDA Sporulation protein YyaC FOC77_RS00505 ENOG4105FA0 parb-like partition protein FOC77_RS00510 ENOG4107QJE Chromosome Partitioning Protein FOC77_RS00515 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) FOC77_RS00530 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC77_RS00535 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein FOC77_RS00540 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC77_RS00545 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FOC77_RS00550 ENOG4105VG0 50S ribosomal protein l34 FOC77_RS00555 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FOC77_RS00560 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC77_RS00565 ENOG410848D S4 domain protein YaaA FOC77_RS00570 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOC77_RS00580 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC77_RS00585 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC77_RS00590 ENOG4105DHT Metal Dependent Phosphohydrolase FOC77_RS00625 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC77_RS00635 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FOC77_RS00640 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FOC77_RS00645 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FOC77_RS00655 ENOG4105ZMH deoxynucleoside kinase FOC77_RS00665 ENOG4108VEU Thiamine monophosphate synthase FOC77_RS00680 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FOC77_RS00685 ENOG4105D06 uba thif-type nad fad binding protein FOC77_RS00690 ENOG4105VRS hydrolase family 18 FOC77_RS00695 ENOG4105GTG Isochorismatase FOC77_RS00700 ENOG4108Z6B deaminase FOC77_RS00710 ENOG4105C6E dna polymerase iii FOC77_RS00715 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FOC77_RS00720 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FOC77_RS00730 ENOG41067KS pro-sigma K processing FOC77_RS00765 ENOG4105CXN decarboxylase FOC77_RS00775 ENOG4105X0R protein from nitrogen regulatory protein P-II FOC77_RS00785 ENOG4105FA2 dna polymerase iii FOC77_RS00790 ENOG4105MA4 psp1 domain protein FOC77_RS00795 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) FOC77_RS00800 ENOG41060K3 Methyltransferase FOC77_RS00805 ENOG4105VC4 domain protein FOC77_RS00810 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC77_RS00815 ENOG4105KRN Transcriptional regulator, abrb family FOC77_RS00820 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC77_RS00825 ENOG4105F8V Hydrolase, tatD family FOC77_RS00830 ENOG41069ER domain protein FOC77_RS00835 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC77_RS00840 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FOC77_RS00845 ENOG4105XFA sporulation peptidase YabG FOC77_RS00850 ENOG4105W42 Veg protein FOC77_RS00860 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FOC77_RS00865 ENOG4105DFT pur operon repressor FOC77_RS00870 ENOG4105KME endoribonuclease L-psp FOC77_RS00875 ENOG4105K4W Could be involved in septation (By similarity) FOC77_RS00880 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FOC77_RS00885 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC77_RS00890 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FOC77_RS00905 ENOG4108JA2 transcriptioN-repair coupling factor FOC77_RS00910 ENOG4108M14 stage v sporulation protein t FOC77_RS00930 ENOG4108IY2 MazG family FOC77_RS00935 ENOG41082I2 s4 domain protein FOC77_RS00940 ENOG4105VYY sporulation protein yabp FOC77_RS00955 ENOG41060GV RNA binding s1 domain protein FOC77_RS00980 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC77_RS00985 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC77_RS00990 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC77_RS00995 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FOC77_RS01000 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FOC77_RS01005 ENOG4105C6T cysteine synthase FOC77_RS01010 ENOG4105CRQ synthase (Component I) FOC77_RS01015 ENOG4105DDQ anthranilate synthase FOC77_RS01020 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC77_RS01025 ENOG4105EEI dihydropteroate synthase FOC77_RS01030 ENOG4105KRF dihydroneopterin aldolase FOC77_RS01035 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC77_RS01045 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC77_RS01050 ENOG4105CRK lysyL-tRNA synthetase FOC77_RS01135 ENOG4108Z0C Uvrb UvrC protein FOC77_RS01140 ENOG41066A3 ATP guanido phosphotransferase FOC77_RS01150 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC77_RS01155 ENOG4105CTP PilT protein domain protein FOC77_RS01160 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOC77_RS01165 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FOC77_RS01170 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FOC77_RS01175 ENOG4105D7W serine acetyltransferase FOC77_RS01180 ENOG4105C8N cysteinyl-tRNA synthetase FOC77_RS01190 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC77_RS01195 ENOG4105M0M Tetracycline resistance protein FOC77_RS01200 ENOG4105QIV RNA polymerase FOC77_RS01205 ENOG4107FTN 50S ribosomal protein L33 FOC77_RS01215 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC77_RS01225 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FOC77_RS01235 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FOC77_RS01240 ENOG4107Y49 methyltransferase FOC77_RS01245 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC77_RS01250 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC77_RS01255 ENOG4105XPM ribosomal protein FOC77_RS01260 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FOC77_RS01265 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FOC77_RS01275 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOC77_RS01290 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FOC77_RS01295 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FOC77_RS01300 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FOC77_RS01305 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FOC77_RS01315 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FOC77_RS01320 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FOC77_RS01325 ENOG41082SA 50s ribosomal protein l29 FOC77_RS01330 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FOC77_RS01335 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FOC77_RS01355 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FOC77_RS01360 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC77_RS01365 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FOC77_RS01370 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FOC77_RS01375 ENOG4105VPB 50S ribosomal protein L30 FOC77_RS01380 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FOC77_RS01385 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC77_RS01390 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FOC77_RS01395 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FOC77_RS01405 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FOC77_RS01415 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC77_RS01420 ENOG4108ZT0 50S ribosomal protein l17 FOC77_RS01425 ENOG4108JJB ABC transporter FOC77_RS01430 ENOG4108JJB ABC transporter FOC77_RS01435 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC77_RS01445 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FOC77_RS01465 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC77_RS01475 ENOG4107TXC Transcriptional regulator FOC77_RS01480 ENOG4105FQP Beta-lactamase FOC77_RS01490 ENOG41079CX FOC77_RS01520 ENOG4105D1F ATP-binding protein FOC77_RS01530 ENOG4108NMV polysaccharide deacetylase FOC77_RS01605 ENOG4105EMN RNA polymerase sigma factor FOC77_RS01615 ENOG4105C8B TIGR00159 family FOC77_RS01620 ENOG4107U5W ybbr family FOC77_RS01625 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FOC77_RS01630 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC77_RS01635 ENOG4105F2Z 3-oxoadipate enol-lactonase FOC77_RS01640 ENOG410600Z Regulatory protein MarR FOC77_RS01645 ENOG4106WTF Glycosyl transferase, family 2 FOC77_RS01675 ENOG4105FS7 Transcriptional regulator FOC77_RS01690 ENOG4108TVJ Nitroreductase FOC77_RS01705 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC77_RS01735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC77_RS01760 ENOG4105KVH Transcriptional regulator FOC77_RS01770 ENOG4105CHR reductase FOC77_RS01785 ENOG4105DJ2 Major Facilitator Superfamily FOC77_RS01800 ENOG4105DQ5 transport system permease protein FOC77_RS01805 ENOG4105TVJ transport system, permease FOC77_RS01810 ENOG4105E0A ABC, transporter FOC77_RS01840 ENOG4108RCF TRANSCRIPTIONal FOC77_RS01850 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC77_RS01855 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC77_RS01870 ENOG4105C8Q Methyl-accepting chemotaxis FOC77_RS01885 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC77_RS01890 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC77_RS01910 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC77_RS01920 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC77_RS01930 ENOG4105EMN RNA polymerase sigma factor FOC77_RS01940 ENOG4108KGH TRANSCRIPTIONal FOC77_RS01950 ENOG4105I4A GCN5-related N-acetyltransferase FOC77_RS01990 ENOG4107FKK extracellular solute-binding protein family 1 FOC77_RS02000 ENOG4105EG2 ABC transporter, permease FOC77_RS02020 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC77_RS02025 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC77_RS02030 ENOG4105DUM transcriptional regulator, lysR family FOC77_RS02045 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FOC77_RS02055 ENOG4107RIQ Sulfate adenylate transferase FOC77_RS02060 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC77_RS02065 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC77_RS02070 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC77_RS02075 ENOG4108Z73 Siroheme synthase FOC77_RS02120 ENOG4105DQ6 Transposase FOC77_RS02145 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC77_RS02155 ENOG4105EWU Squalene--hopene cyclase FOC77_RS02160 ENOG4105C5S asparaginyl-tRNA synthetase FOC77_RS02165 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC77_RS02175 ENOG4105CHH sulfate transporter FOC77_RS02185 ENOG41067QW Transcriptional regulator FOC77_RS02190 ENOG4105F8D glycoside hydrolase family 4 FOC77_RS02195 ENOG4105CI1 PTS System FOC77_RS02200 ENOG4105HX0 Transcriptional regulator FOC77_RS02220 ENOG4105CK1 PTS System FOC77_RS02230 ENOG4105C72 UPF0176 protein FOC77_RS02245 ENOG4105E0C molybdate abc transporter FOC77_RS02250 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC77_RS02255 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC77_RS02290 ENOG4105CEP NADH dehydrogenase FOC77_RS02305 ENOG4108JJB ABC transporter FOC77_RS02325 ENOG4105D3Q Sugar transferase FOC77_RS02330 ENOG4105PSV Polysaccharide Biosynthesis Protein FOC77_RS02335 ENOG4107RA4 Glycosyl transferase (Group 1 FOC77_RS02340 ENOG4105CMR udp-glucose 4-epimerase FOC77_RS02345 ENOG4105QZI O-Antigen Polymerase FOC77_RS02360 ENOG4107EF8 Glycosyl transferase (Group 1 FOC77_RS02365 ENOG4108Z40 Transcriptional regulator FOC77_RS02370 ENOG4105C1Q protoporphyrinogen oxidase FOC77_RS02385 ENOG4108ME1 Peptidase M55 D-aminopeptidase FOC77_RS02390 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC77_RS02395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC77_RS02400 ENOG4105C3U ABC transporter FOC77_RS02410 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC77_RS02415 ENOG4105DTQ mandelate racemase muconate lactonizing FOC77_RS02420 ENOG4107SN7 NLP P60 protein FOC77_RS02425 ENOG4108JQ7 (ABC) transporter FOC77_RS02435 ENOG4105E0A ABC, transporter FOC77_RS02440 ENOG4105D4A Cell wall formation (By similarity) FOC77_RS02450 ENOG4107SET aldo keto reductase FOC77_RS02455 ENOG4105C01 Dihydroxy-acid dehydratase FOC77_RS02460 ENOG4106F5Q Membrane FOC77_RS02470 ENOG4105C37 (CBS) domain FOC77_RS02480 ENOG4105ETD TRANSCRIPTIONal FOC77_RS02490 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FOC77_RS02495 ENOG4105BZ4 penicillin-binding protein FOC77_RS02500 ENOG4105E2S oxidase) subunit II FOC77_RS02505 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC77_RS02520 ENOG4105DHS permease protein FOC77_RS02525 ENOG4105CM4 permease protein FOC77_RS02530 ENOG4108IPW abc transporter atp-binding protein FOC77_RS02540 ENOG4105EE0 oxidoreductase FOC77_RS02545 ENOG4105EVU fructokinase FOC77_RS02550 ENOG4105BZU Histidine kinase FOC77_RS02555 ENOG4105C0H protease FOC77_RS02560 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC77_RS02565 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC77_RS02590 ENOG4105F38 ABC transporter, permease FOC77_RS02595 ENOG4105D38 putrescine abc transporter FOC77_RS02600 ENOG4107RUE extracellular solute-binding protein family 1 FOC77_RS02605 ENOG4105PXI polysaccharide deacetylase FOC77_RS02615 ENOG4107ZYR domain protein FOC77_RS02620 ENOG4105HUF DNA protection during starvation protein FOC77_RS02630 ENOG4105CJW magnesium transporter FOC77_RS02635 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FOC77_RS02650 ENOG4105PW4 Sugar fermentation stimulation protein homolog FOC77_RS02655 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FOC77_RS02660 ENOG4105EHG Permease protein FOC77_RS02665 ENOG4105E0A ABC, transporter FOC77_RS02670 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FOC77_RS02675 ENOG4107QZB decarboxylase FOC77_RS02685 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FOC77_RS02690 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FOC77_RS02695 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC77_RS02705 ENOG4108WBT adenosyltransferase FOC77_RS02720 ENOG4105CPF Cell wall formation (By similarity) FOC77_RS02725 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC77_RS02735 ENOG4105C1J atp-dependent rna helicase FOC77_RS02740 ENOG410905X membrane-flanked domain protein FOC77_RS02745 ENOG4105CKV Membrane FOC77_RS02755 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FOC77_RS02760 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC77_RS02775 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC77_RS02785 ENOG4105FUA antagonist FOC77_RS02790 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FOC77_RS02795 ENOG4107SGM protein serine threonine phosphatase FOC77_RS02800 ENOG4105WN5 stage II sporulation protein FOC77_RS02805 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FOC77_RS02815 ENOG41064BQ Phosphatase FOC77_RS02830 ENOG410906U SprT-like FOC77_RS02910 ENOG4105K8N protein family UPF0079, ATPase FOC77_RS02915 ENOG41072GX Peptidase M22 Glycoprotease FOC77_RS02920 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC77_RS02925 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC77_RS02930 ENOG4105C5H ABC transporter FOC77_RS02935 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC77_RS02940 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FOC77_RS02950 ENOG4108TYN CAAX amino terminal protease family protein FOC77_RS02955 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FOC77_RS02960 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOC77_RS02965 ENOG4105VTR Integrase FOC77_RS02980 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase FOC77_RS03010 ENOG4108YRF PTS System FOC77_RS03015 ENOG4105DM4 PTS System FOC77_RS03020 ENOG4105DM4 PTS System FOC77_RS03025 ENOG4105UP7 3-epimerase FOC77_RS03045 ENOG4105ETZ PTS System FOC77_RS03050 ENOG4105F3R pts system mannose fructose sorbose family iid FOC77_RS03055 ENOG4105D9R oxidoreductase FOC77_RS03060 ENOG4105CN5 Metallo-Beta-Lactamase FOC77_RS03065 ENOG4105QE3 oxidoreductase FOC77_RS03080 ENOG4105C8Q Methyl-accepting chemotaxis FOC77_RS03095 ENOG4108MRH transcriptional regulatory protein FOC77_RS03100 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FOC77_RS03105 ENOG4105C6K Malic enzyme FOC77_RS03115 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FOC77_RS03130 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC77_RS03135 ENOG4105DCG PHP domain protein FOC77_RS03140 ENOG4105F6S Spore photoproduct lyase FOC77_RS03155 ENOG410606W general stress protein FOC77_RS03175 ENOG4105E5W Transporter FOC77_RS03200 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FOC77_RS03210 ENOG4105D2H Uronic isomerase FOC77_RS03215 ENOG4105C5Y PTS System FOC77_RS03220 ENOG4105CS2 ec 3.2.1.21 FOC77_RS03225 ENOG4105CID antiterminator FOC77_RS03235 ENOG4106FN3 tellurium resistance protein FOC77_RS03240 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC77_RS03255 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC77_RS03260 ENOG4105HF0 Membrane FOC77_RS03265 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FOC77_RS03275 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC77_RS03280 ENOG4105C7N Xanthine uracil vitamin C permease FOC77_RS03285 ENOG4105CID antiterminator FOC77_RS03310 ENOG4105DA5 (ABC) transporter FOC77_RS03335 ENOG4105FQP Beta-lactamase FOC77_RS03370 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC77_RS03375 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC77_RS03380 ENOG4105C83 adenylosuccinate lyase FOC77_RS03385 ENOG4105C8V SAICAR synthetase FOC77_RS03390 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC77_RS03395 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FOC77_RS03400 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FOC77_RS03410 ENOG4105CXB phosphoribosylaminoimidazole synthetase FOC77_RS03415 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC77_RS03420 ENOG4105DC1 bifunctional purine biosynthesis protein purh FOC77_RS03425 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC77_RS03430 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC77_RS03445 ENOG4108R5T secreted protein FOC77_RS03450 ENOG4105KGF protein, YerC YecD FOC77_RS03455 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) FOC77_RS03460 ENOG4105C4R Atp-dependent dna helicase FOC77_RS03465 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOC77_RS03485 ENOG4105K56 Transcriptional regulator FOC77_RS03490 ENOG4107RBI VanW family FOC77_RS03495 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOC77_RS03500 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC77_RS03505 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOC77_RS03515 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC77_RS03525 ENOG4105DU6 RNA polymerase FOC77_RS03545 ENOG4105CBD Diacylglycerol kinase FOC77_RS03550 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC77_RS03565 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC77_RS03620 ENOG4105Q2H domain protein FOC77_RS03635 ENOG4105CDU Replicative dna helicase FOC77_RS03760 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC77_RS03845 ENOG41060YP FOC77_RS03895 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) FOC77_RS03910 ENOG4108W0I acetyltransferase FOC77_RS03915 ENOG41069ER domain protein FOC77_RS03935 ENOG4105C2F Histidine kinase FOC77_RS03950 ENOG4105BZU Histidine kinase FOC77_RS03970 ENOG4105KVH Transcriptional regulator FOC77_RS03975 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC77_RS03990 ENOG4105G6Z alkaline phosphatase FOC77_RS04000 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC77_RS04005 ENOG41063PX domain protein FOC77_RS04015 ENOG4105DY9 regulatoR FOC77_RS04035 ENOG4105K7K Transcriptional regulator FOC77_RS04060 ENOG4105CJA serine threonine protein kinase FOC77_RS04065 ENOG4105BZ1 (ABC) transporter FOC77_RS04080 ENOG4105CX6 glutaminyL-tRNA synthetase FOC77_RS04090 ENOG4108UMN azlc family FOC77_RS04115 ENOG4105CFH Aspartokinase FOC77_RS04125 ENOG4105E5Q amino acid AbC transporter FOC77_RS04130 ENOG4105CDA abc transporter atp-binding protein FOC77_RS04150 ENOG4105C3U ABC transporter FOC77_RS04155 ENOG4108JQ7 (ABC) transporter FOC77_RS04165 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC77_RS04175 ENOG4105BZ1 (ABC) transporter FOC77_RS04180 ENOG4105BZ1 (ABC) transporter FOC77_RS04190 ENOG4105FDU atp-dependent rna helicase FOC77_RS04210 ENOG4105E1K spore germination protein FOC77_RS04215 ENOG4108NHD germination protein FOC77_RS04235 ENOG4105ENE Histidine kinase FOC77_RS04240 ENOG4105WH1 Two component transcriptional regulator luxr family FOC77_RS04265 ENOG4108S4H thioesterase Superfamily protein FOC77_RS04275 ENOG4106I4J membrane FOC77_RS04285 ENOG410855V Acylphosphatase FOC77_RS04300 ENOG4107URF beta-phospho-glucomutase FOC77_RS04305 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC77_RS04320 ENOG4105E14 MotA TolQ exbB proton channel FOC77_RS04325 ENOG4105ER2 Ompa motb domain protein FOC77_RS04330 ENOG4105DD7 kinase (PfkB family FOC77_RS04335 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FOC77_RS04355 ENOG4108IMY Transcriptional regulator FOC77_RS04360 ENOG4107414 GntR family transcriptional regulator FOC77_RS04365 ENOG4107RKG DJ-1/PfpI family FOC77_RS04370 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC77_RS04375 ENOG41068PA UPF0435 protein FOC77_RS04380 ENOG4105KJF protein tyrosine phosphatase FOC77_RS04390 ENOG4107U9T Pfam:Ribonuclease_BN FOC77_RS04395 ENOG4105C59 p-type ATPase FOC77_RS04400 ENOG4108ISG Major Facilitator FOC77_RS04405 ENOG4105UPD Calcium Proton FOC77_RS04445 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC77_RS04455 ENOG4108HW3 (ABC) transporter FOC77_RS04500 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FOC77_RS04505 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC77_RS04510 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC77_RS04515 ENOG4107V2S Transcriptional regulator FOC77_RS04520 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC77_RS04530 ENOG4107SWG transcriptional regulator MERR family FOC77_RS04605 ENOG4105C5H ABC transporter FOC77_RS04610 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) FOC77_RS04620 ENOG4105CGH 5'-nucleotidase FOC77_RS04625 ENOG4107T9C Alpha amylase catalytic region FOC77_RS04640 ENOG4108W15 Protein of unknown function (DUF1456) FOC77_RS04650 ENOG4107RSM transcriptional regulator FOC77_RS04660 ENOG4105IIP Membrane FOC77_RS04675 ENOG4108IJ8 ABC transporter FOC77_RS04680 ENOG4105E90 ABC transporter FOC77_RS04690 ENOG4105CVA phosphate FOC77_RS04695 ENOG4105C8U phosphate abc transporter FOC77_RS04700 ENOG4105E2Z phosphate ABC transporter (Permease FOC77_RS04725 ENOG4105EQD regulatoR FOC77_RS04730 ENOG4105DFW ABC transporter FOC77_RS04735 ENOG4105C2J ABC transporter FOC77_RS04740 ENOG4108HWW ABC transporter FOC77_RS04745 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC77_RS04765 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC77_RS04775 ENOG4105ECR NmrA family FOC77_RS04780 ENOG4105KVH Transcriptional regulator FOC77_RS04790 ENOG4105E5Q amino acid AbC transporter FOC77_RS04825 ENOG4105BZU Histidine kinase FOC77_RS04830 ENOG4105CNG UPF0061 protein FOC77_RS04835 ENOG4105DQX Zinc finger domain FOC77_RS04840 ENOG4108WV1 Pfam:DUF477 FOC77_RS04885 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FOC77_RS04895 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC77_RS04900 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC77_RS04905 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC77_RS04910 ENOG4108AEY RNA polymerase sigma factor FOC77_RS04915 ENOG4105J37 FOC77_RS04925 ENOG4105BZ1 (ABC) transporter FOC77_RS04930 ENOG4105BZ1 (ABC) transporter FOC77_RS04955 ENOG4105C8Q Methyl-accepting chemotaxis FOC77_RS04965 ENOG410746C Acid-soluble spore protein O FOC77_RS04975 ENOG4108HRK Histidine kinase FOC77_RS04980 ENOG4105DY9 regulatoR FOC77_RS04985 ENOG4105FCD Major Facilitator FOC77_RS04995 ENOG4105CDW Resistance protein FOC77_RS05000 ENOG410807C QueT transporter FOC77_RS05015 ENOG4105C19 ABC transporter FOC77_RS05020 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC77_RS05025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC77_RS05030 ENOG4105BZU Histidine kinase FOC77_RS05035 ENOG4108S4H thioesterase Superfamily protein FOC77_RS05045 ENOG4105CP9 extracellular ligand-binding receptor FOC77_RS05050 ENOG4105C32 Amino acid ABC transporter (Permease) FOC77_RS05055 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC77_RS05060 ENOG4105C0Z ABC transporter FOC77_RS05065 ENOG4108IV0 ABC, transporter FOC77_RS05070 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC77_RS05075 ENOG4106Z5D Glycoside Hydrolase Family 43 FOC77_RS05085 ENOG410902V Modulates RecA activity (By similarity) FOC77_RS05095 ENOG4105XHU Acid-soluble spore protein K FOC77_RS05105 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC77_RS05110 ENOG4105CEN a g-specific adenine glycosylase FOC77_RS05115 ENOG4106BXE FOC77_RS05120 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FOC77_RS05140 ENOG4105BZ1 (ABC) transporter FOC77_RS05145 ENOG4107NBY Membrane FOC77_RS05150 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FOC77_RS05160 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC77_RS05165 ENOG4105G5W regulator Fur family FOC77_RS05260 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC77_RS05395 ENOG4105C2M dna polymerase I FOC77_RS05420 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FOC77_RS05435 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC77_RS05440 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC77_RS05465 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC77_RS05485 ENOG4105DVF Cytosine-specific methyltransferase FOC77_RS05635 ENOG4107X35 defense response to bacterium FOC77_RS05760 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FOC77_RS05780 ENOG4105DZR Type I site-specific deoxyribonuclease FOC77_RS05785 ENOG4105DQ6 Transposase FOC77_RS05820 ENOG4105EQK -acetyltransferase FOC77_RS05840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC77_RS05845 ENOG4108SWU Histidine kinase FOC77_RS05855 ENOG4105BZ1 (ABC) transporter FOC77_RS05885 ENOG4105VCP PTS System FOC77_RS05900 ENOG4105CK1 PTS System FOC77_RS05905 ENOG4105CS2 ec 3.2.1.21 FOC77_RS05910 ENOG4105EMD TRANSCRIPTIONal FOC77_RS05950 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FOC77_RS05965 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FOC77_RS05990 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC77_RS05995 ENOG4108MEK Metal-binding protein YodA FOC77_RS06000 ENOG4105DSE periplasmic solute binding protein FOC77_RS06020 ENOG4108MES Periplasmic binding protein FOC77_RS06025 ENOG4105DQ5 transport system permease protein FOC77_RS06030 ENOG4108IHU transport system permease protein FOC77_RS06035 ENOG4105E0A ABC, transporter FOC77_RS06040 ENOG4105CPC Aldo Keto reductase FOC77_RS06050 ENOG4105CF7 AraC family transcriptional regulator FOC77_RS06055 ENOG4105F5H Glycosyl Hydrolase Family 88 FOC77_RS06060 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) FOC77_RS06085 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC77_RS06090 ENOG4105CID antiterminator FOC77_RS06095 ENOG4105C5Y PTS System FOC77_RS06100 ENOG4105CS2 ec 3.2.1.21 FOC77_RS06105 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC77_RS06115 ENOG4105C2C drug resistance transporter, Bcr CflA FOC77_RS06120 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FOC77_RS06125 ENOG4105DM4 PTS System FOC77_RS06130 ENOG4105D2N Aldolase FOC77_RS06135 ENOG4105E98 transcriptional regulator DeoR family FOC77_RS06140 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FOC77_RS06150 ENOG4105BZ1 (ABC) transporter FOC77_RS06155 ENOG4105C4X radical SAM domain protein FOC77_RS06165 ENOG4105CS2 ec 3.2.1.21 FOC77_RS06210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC77_RS06230 ENOG4107R6F Alpha Beta Hydrolase Fold protein FOC77_RS06235 ENOG4108MJI response regulator FOC77_RS06240 ENOG41090MY MarR family Transcriptional regulator FOC77_RS06245 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC77_RS06250 ENOG4107XWI flavin reductase domain protein, FMN-binding FOC77_RS06255 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC77_RS06260 ENOG4105FBA Phospholipase Carboxylesterase FOC77_RS06265 ENOG4105CS1 NAD(P)H quinone oxidoreductase FOC77_RS06275 ENOG4108NGU Transcriptional regulator FOC77_RS06285 ENOG4105CUC YeeE YedE family protein FOC77_RS06290 ENOG4105CGH 5'-nucleotidase FOC77_RS06300 ENOG4108XFG YwhD family FOC77_RS06310 ENOG4107V0Z fmn reductase FOC77_RS06330 ENOG4105C6T cysteine synthase FOC77_RS06350 ENOG4105PDP Short chain dehydrogenase FOC77_RS06365 ENOG4105KVH Transcriptional regulator FOC77_RS06370 ENOG4107ZTW SNARE associated Golgi FOC77_RS06390 ENOG4105E2A Dehydrogenase FOC77_RS06400 ENOG4108QTI )-transporter FOC77_RS06405 ENOG4105CNH Multidrug resistance protein MdtL FOC77_RS06420 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC77_RS06435 ENOG4108DBC nitroreductase FOC77_RS06440 ENOG4105CYN Serine protein kinase FOC77_RS06470 ENOG4105WD1 Membrane FOC77_RS06485 ENOG4105CPC Aldo Keto reductase FOC77_RS06490 ENOG4105ID8 Transcriptional regulator, ARAC family FOC77_RS06495 ENOG4105C5Y PTS System FOC77_RS06500 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FOC77_RS06505 ENOG4105DHI Methyltransferase FOC77_RS06520 ENOG4105DHI Methyltransferase FOC77_RS06535 ENOG4108XET gCN5-related N-acetyltransferase FOC77_RS06540 ENOG4108Z7R Chaperone CsaA FOC77_RS06565 ENOG4108XXK NUDIX hydrolase FOC77_RS06570 ENOG4105H67 Protein of unknown function (DUF421) FOC77_RS06595 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FOC77_RS06600 ENOG4105G7B Protein of unknown function (DUF2992) FOC77_RS06615 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC77_RS06620 ENOG4106AXJ AraC family transcriptional regulator FOC77_RS06630 ENOG4105UNS Pfam:DUF419 FOC77_RS06640 ENOG4105ETE Transcriptional regulator (LacI family FOC77_RS06650 ENOG4108HHA Transketolase FOC77_RS06655 ENOG4108IUS Transketolase FOC77_RS06660 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FOC77_RS06665 ENOG4105C5Y PTS System FOC77_RS06675 ENOG4105JQZ Methyltransferase FOC77_RS06685 ENOG4108S01 response regulator FOC77_RS06690 ENOG4108ZGX Histidine kinase FOC77_RS06695 ENOG4105ECK Fatty Acid Desaturase FOC77_RS06700 ENOG4105C22 threonyL-tRNA synthetase FOC77_RS06710 ENOG4108IMY Transcriptional regulator FOC77_RS06725 ENOG4105II7 pyrroline-5-carboxylate reductase FOC77_RS06740 ENOG4107QJZ Glycosyl transferase, family 2 FOC77_RS06750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC77_RS06755 ENOG4105BZU Histidine kinase FOC77_RS06760 ENOG4108JYZ YitT family FOC77_RS06770 ENOG4107XNU peptidase FOC77_RS06775 ENOG4105CJ3 phosphate transporter FOC77_RS06780 ENOG4107GRR phosphate transport regulator FOC77_RS06785 ENOG4105E1F short-chain dehydrogenase reductase FOC77_RS06795 ENOG4107BMA Transglycosylase associated protein FOC77_RS06800 ENOG4108YBP pseudouridine synthase FOC77_RS06820 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC77_RS06840 ENOG4105C7N Xanthine uracil vitamin C permease FOC77_RS06850 ENOG4105KBX Transcriptional regulator, TetR family FOC77_RS06855 ENOG4105KPY Small multidrug resistance protein FOC77_RS06860 ENOG4105RXJ FOC77_RS06865 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FOC77_RS06870 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC77_RS06900 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC77_RS06915 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC77_RS06935 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC77_RS06940 ENOG4105CJ1 ABC, transporter FOC77_RS06950 ENOG4108JYZ YitT family FOC77_RS06955 ENOG4105D7N magnesium and cobalt transport protein CorA FOC77_RS06960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC77_RS06965 ENOG4105C37 (CBS) domain FOC77_RS06970 ENOG4105C37 (CBS) domain FOC77_RS06980 ENOG4105EC8 Methyl-accepting chemotaxis FOC77_RS06995 ENOG4105BZ1 (ABC) transporter FOC77_RS07000 ENOG4105BZ1 (ABC) transporter FOC77_RS07005 ENOG4105NIV Esterase FOC77_RS07010 ENOG410874W AraC family transcriptional regulator FOC77_RS07030 ENOG4108SA1 esterase FOC77_RS07060 ENOG410839P FOC77_RS07065 ENOG410839P FOC77_RS07080 ENOG4105WZB UPF0342 protein FOC77_RS07085 ENOG4105YWU small acid-soluble spore protein FOC77_RS07095 ENOG4105D4P Coproporphyrinogen iii oxidase FOC77_RS07100 ENOG4105C7N Xanthine uracil vitamin C permease FOC77_RS07105 ENOG4108IUX (ABC) transporter FOC77_RS07110 ENOG4105RHA ABC transporter, permease FOC77_RS07115 ENOG4107VRP DNA repair exonuclease FOC77_RS07120 ENOG4106D4I domain protein FOC77_RS07165 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOC77_RS07170 ENOG4105K59 histidine triad (HIT) protein FOC77_RS07210 ENOG4105ENE Histidine kinase FOC77_RS07215 ENOG4105WH1 Two component transcriptional regulator luxr family FOC77_RS07225 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC77_RS07230 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC77_RS07240 ENOG4105ECB domain protein FOC77_RS07245 ENOG4105DF9 Lipoate-protein, ligase FOC77_RS07250 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC77_RS07265 ENOG41060YP FOC77_RS07270 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC77_RS07275 ENOG4108RCF TRANSCRIPTIONal FOC77_RS07295 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC77_RS07335 ENOG4105ERH Fumarylacetoacetate hydrolase FOC77_RS07340 ENOG4105YHS UPF0344 protein FOC77_RS07345 ENOG4105BZU Histidine kinase FOC77_RS07350 ENOG4105WH1 Two component transcriptional regulator luxr family FOC77_RS07355 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC77_RS07360 ENOG4105C37 (CBS) domain FOC77_RS07365 ENOG4105CJ1 ABC, transporter FOC77_RS07380 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC77_RS07385 ENOG4106KNT transcriptional regulator FOC77_RS07390 ENOG4105D9R oxidoreductase FOC77_RS07395 ENOG4105EE0 oxidoreductase FOC77_RS07405 ENOG41075H3 AraC family transcriptional regulator FOC77_RS07415 ENOG4105VRR gCN5-related N-acetyltransferase FOC77_RS07430 ENOG4105CAQ asparagine synthetase FOC77_RS07455 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC77_RS07460 ENOG4108VPT UPF0234 protein FOC77_RS07465 ENOG4105QNR S1 RNA binding domain protein FOC77_RS07475 ENOG4105EPR degv family FOC77_RS07480 ENOG4107AYK membrAne FOC77_RS07490 ENOG41073B9 FOC77_RS07500 ENOG4108KP7 hydrolase FOC77_RS07505 ENOG4108MXZ Esterase FOC77_RS07510 ENOG4105VG1 fes assembly suf system protein FOC77_RS07515 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC77_RS07520 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC77_RS07525 ENOG4105DAA L-lactate FOC77_RS07530 ENOG4105JXH GntR family transcriptional regulator FOC77_RS07535 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC77_RS07540 ENOG4107QR9 Iron-sulfur cluster binding protein FOC77_RS07545 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC77_RS07550 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FOC77_RS07555 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC77_RS07560 ENOG4105CAS nag kinase FOC77_RS07580 ENOG4105DBV ornithine carbamoyltransferase FOC77_RS07590 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC77_RS07610 ENOG4107RMD Basic membrane lipoprotein FOC77_RS07615 ENOG4105CHR reductase FOC77_RS07620 ENOG4105ETD TRANSCRIPTIONal FOC77_RS07630 ENOG410787A Pts system, glucitol sorbitol-specific FOC77_RS07635 ENOG4105DZY Pts system, glucitol sorbitol-specific FOC77_RS07645 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC77_RS07650 ENOG4108X4Q Hydrolase FOC77_RS07660 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC77_RS07665 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC77_RS07670 ENOG4105G5W regulator Fur family FOC77_RS07680 ENOG4108KU1 UPF0736 protein FOC77_RS07685 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC77_RS07690 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC77_RS07695 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC77_RS07700 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC77_RS07710 ENOG4108JQ7 (ABC) transporter FOC77_RS07725 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FOC77_RS07730 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis FOC77_RS07735 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC77_RS07745 ENOG4105DPN Oligoendopeptidase f FOC77_RS07750 ENOG4105T58 Dithiol-disulfide isomerase FOC77_RS07755 ENOG4108Z18 K06886 hemoglobin FOC77_RS07760 ENOG4105E4C Lytic transglycosylase catalytic FOC77_RS07765 ENOG4105MIX Adenylate cyclase FOC77_RS07780 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC77_RS07785 ENOG4105EMS pseudouridine synthase FOC77_RS07790 ENOG4107S1Q Phosphatase FOC77_RS07795 ENOG4105CJW magnesium transporter FOC77_RS07805 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FOC77_RS07830 ENOG41090VF Stage v sporulation protein ac FOC77_RS07835 ENOG4105CZ3 stage V sporulation protein ad FOC77_RS07850 ENOG4105EKQ RNA-directed DNA polymerase FOC77_RS07860 ENOG4105ENA helicase FOC77_RS07870 ENOG4105H67 Protein of unknown function (DUF421) FOC77_RS07880 ENOG4108ZMI UPF0477 protein FOC77_RS07890 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC77_RS07895 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FOC77_RS07905 ENOG4108UZX fmn reductase FOC77_RS07920 ENOG4108ZJ4 polysaccharide deacetylase FOC77_RS07925 ENOG4105C6Z Gluconate FOC77_RS07930 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC77_RS07945 ENOG4106KNT transcriptional regulator FOC77_RS07960 ENOG4105CMG Carbohydrate kinase FOC77_RS07975 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FOC77_RS07980 ENOG4105CMR udp-glucose 4-epimerase FOC77_RS07985 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase FOC77_RS07990 ENOG4105K64 Glycosyl transferase, family 2 FOC77_RS08000 ENOG4105CE4 GlcNAc 6-P deacetylase FOC77_RS08005 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FOC77_RS08020 ENOG4105ENE Histidine kinase FOC77_RS08025 ENOG4108VB1 regulatoR FOC77_RS08030 ENOG4105EYF MMPL domain protein FOC77_RS08035 ENOG4105E7W lamb ycsf family protein FOC77_RS08045 ENOG4105DUX Transporter FOC77_RS08060 ENOG4105DJV ribulose-phosphate 3-epimerase FOC77_RS08070 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC77_RS08090 ENOG4107XVH Transcriptional regulator FOC77_RS08095 ENOG4105DET Rhamnulokinase FOC77_RS08100 ENOG4105DKG l-rhamnose isomerase FOC77_RS08110 ENOG4105C2F Histidine kinase FOC77_RS08115 ENOG4107VQW regulatoR FOC77_RS08130 ENOG4108HWW ABC transporter FOC77_RS08135 ENOG4105E98 transcriptional regulator DeoR family FOC77_RS08150 ENOG4105CG3 alpha amylase, catalytic region FOC77_RS08160 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FOC77_RS08165 ENOG41090R9 glycosyltransferase FOC77_RS08175 ENOG4105FAW cDP-glucose 4,6-dehydratase FOC77_RS08195 ENOG4107S6X Glycosyl transferase, family 2 FOC77_RS08200 ENOG41076HS cation diffusion facilitator family transporter FOC77_RS08205 ENOG410756H nucleotidyltransferase FOC77_RS08215 ENOG4107TUM Amidinotransferase FOC77_RS08225 ENOG4108IG5 Transcriptional regulator FOC77_RS08230 ENOG4105CVA phosphate FOC77_RS08235 ENOG4108IUM Glycogen debranching enzyme FOC77_RS08250 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC77_RS08255 ENOG4105XTG Pfam:DUF156 FOC77_RS08260 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC77_RS08265 ENOG41082J7 Rhodanese domain protein FOC77_RS08300 ENOG4105WEF catalase FOC77_RS08340 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC77_RS08355 ENOG4105CJ1 ABC, transporter FOC77_RS08380 ENOG4108WS4 fmn reductase FOC77_RS08385 ENOG4108NEV two component transcriptional regulator, LytTR family FOC77_RS08390 ENOG4105C2F Histidine kinase FOC77_RS08430 ENOG4107RCC Major Facilitator Superfamily FOC77_RS08440 ENOG4105E2Y ABC, transporter FOC77_RS08445 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC77_RS08450 ENOG4105GVF (ABC) transporter FOC77_RS08460 ENOG4105ETE Transcriptional regulator (LacI family FOC77_RS08470 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOC77_RS08480 ENOG4108HKT sucrose-6-phosphate hydrolase FOC77_RS08485 ENOG4105D7K pfkb domain protein FOC77_RS08490 ENOG4108HKT sucrose-6-phosphate hydrolase FOC77_RS08495 ENOG4108HKT sucrose-6-phosphate hydrolase FOC77_RS08500 ENOG4105EDQ levansucrase EC 2.4.1.10 FOC77_RS08505 ENOG4105XN3 extracellular solute-binding protein family 1 FOC77_RS08510 ENOG4105EQD regulatoR FOC77_RS08515 ENOG4105C2F Histidine kinase FOC77_RS08520 ENOG4105C5Q Transcriptional regulator FOC77_RS08525 ENOG4107R37 Glutamate dehydrogenase FOC77_RS08530 ENOG4105DJB Major Facilitator Superfamily FOC77_RS08535 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC77_RS08545 ENOG4105CS2 ec 3.2.1.21 FOC77_RS08555 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC77_RS08560 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC77_RS08565 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC77_RS08570 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC77_RS08575 ENOG4107V9H nitrite transporter FOC77_RS08605 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FOC77_RS08615 ENOG4105WYW fructose-bisphosphate aldolase FOC77_RS08655 ENOG4105C2X Arabinose 5-phosphate isomerase FOC77_RS08660 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC77_RS08670 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FOC77_RS08680 ENOG4105C26 Dehydrogenase FOC77_RS08685 ENOG4105DH8 myo-inositol catabolism FOC77_RS08690 ENOG4105D7K pfkb domain protein FOC77_RS08705 ENOG4107QNK )-transporter FOC77_RS08710 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOC77_RS08715 ENOG4105F0H myo-inositol catabolism protein FOC77_RS08720 ENOG4107VG4 Xylose isomerase domain protein TIM barrel FOC77_RS08725 ENOG4105D2N Aldolase FOC77_RS08730 ENOG41090U3 tautomerase FOC77_RS08755 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC77_RS08770 ENOG4105ECQ AraC Family Transcriptional Regulator FOC77_RS08780 ENOG4105DRS transport system, permease FOC77_RS08790 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOC77_RS08810 ENOG4107S8A protein TIM barrel FOC77_RS08815 ENOG4105F0V Cell wall hydrolase FOC77_RS08825 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC77_RS08840 ENOG4108HQR Glycine betaine FOC77_RS08850 ENOG4105FTV AraC Family Transcriptional Regulator FOC77_RS08870 ENOG4105C4C beta-galactosidase FOC77_RS08875 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC77_RS08880 ENOG4105F0V Cell wall hydrolase FOC77_RS08890 ENOG4107HP6 Transcriptional regulator FOC77_RS08895 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC77_RS08900 ENOG4105C01 Dihydroxy-acid dehydratase FOC77_RS08910 ENOG4105DSG hydrolase family 43 FOC77_RS08920 ENOG41090KR LysR family transcriptional Regulator FOC77_RS08930 ENOG4108UQV Membrane FOC77_RS08940 ENOG4108IJ9 (ABC) transporter FOC77_RS08945 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FOC77_RS08960 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC77_RS08965 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC77_RS08980 ENOG4105CTB Polyprenyl synthetase FOC77_RS08985 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC77_RS09015 ENOG4105G9B Transcriptional regulator FOC77_RS09020 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FOC77_RS09040 ENOG4108TYN CAAX amino terminal protease family protein FOC77_RS09045 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FOC77_RS09050 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC77_RS09055 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC77_RS09060 ENOG4105EUJ GTP cyclohydrolase i FOC77_RS09065 ENOG4105EMN RNA polymerase sigma factor FOC77_RS09075 ENOG4107R6U sodium dicarboxylate symporter FOC77_RS09080 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC77_RS09105 ENOG4107V0Z fmn reductase FOC77_RS09120 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FOC77_RS09125 ENOG4106Z5D Glycoside Hydrolase Family 43 FOC77_RS09130 ENOG4105MU9 integral membrane protein FOC77_RS09135 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) FOC77_RS09145 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FOC77_RS09150 ENOG4107S2N Type III effector Hrp-dependent FOC77_RS09155 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FOC77_RS09160 ENOG4106R3P AraC family transcriptional regulator FOC77_RS09175 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOC77_RS09180 ENOG4105E0S extracellular solute-binding protein family 1 FOC77_RS09185 ENOG4105MU9 integral membrane protein FOC77_RS09195 ENOG4105C94 Transporter FOC77_RS09210 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC77_RS09215 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FOC77_RS09220 ENOG4108JQ1 Dehydrogenase FOC77_RS09225 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC77_RS09230 ENOG4105C85 amino acid FOC77_RS09235 ENOG4108IUW ABC transporter FOC77_RS09270 ENOG4105BZU Histidine kinase FOC77_RS09280 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC77_RS09295 ENOG4105C26 Dehydrogenase FOC77_RS09300 ENOG4105JVQ RNA Polymerase FOC77_RS09320 ENOG4105ETE Transcriptional regulator (LacI family FOC77_RS09325 ENOG4105CG3 alpha amylase, catalytic region FOC77_RS09330 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FOC77_RS09335 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FOC77_RS09340 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FOC77_RS09350 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) FOC77_RS09365 ENOG4105C2F Histidine kinase FOC77_RS09370 ENOG4107VQW regulatoR FOC77_RS09375 ENOG4105EP8 Glycosyl Hydrolase Family 88 FOC77_RS09400 ENOG4107FCW Abortive infection protein FOC77_RS09425 ENOG4105E35 Dipicolinate synthase subunit A FOC77_RS09445 ENOG4107QP6 Xylose isomerase domain protein TIM barrel FOC77_RS09450 ENOG4105CK5 oxidoreductase FOC77_RS09455 ENOG4105DSE periplasmic solute binding protein FOC77_RS09480 ENOG4105CNI cell division protein FtsW FOC77_RS09490 ENOG4105F04 LysR family Transcriptional regulator FOC77_RS09500 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC77_RS09525 ENOG4108Q5U germination protein, ger(x)c family FOC77_RS09530 ENOG4107Y03 Nitroreductase FOC77_RS09535 ENOG4105HDK L-asparaginase FOC77_RS09545 ENOG4107VFR oxidoreductase FOC77_RS09555 ENOG4105DIK (ABC) transporter FOC77_RS09570 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FOC77_RS09580 ENOG4105KRI phosphocarrier protein (HPr FOC77_RS09585 ENOG4105DKW ABC transporter FOC77_RS09590 ENOG4108X4Q Hydrolase FOC77_RS09605 ENOG4105DZ6 Band 7 protein FOC77_RS09615 ENOG4107SQ8 Glycine betaine FOC77_RS09620 ENOG4108IJ7 Glycine betaine FOC77_RS09625 ENOG4105TRT Transcriptional regulator FOC77_RS09640 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC77_RS09645 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FOC77_RS09650 ENOG4107QXX ABC transporter FOC77_RS09655 ENOG4105EZ7 amino acid ABC transporter FOC77_RS09660 ENOG4105DRP amino acid AbC transporter FOC77_RS09665 ENOG4105CDA abc transporter atp-binding protein FOC77_RS09675 ENOG4107TS3 membrane protein, TerC FOC77_RS09680 ENOG410681C small acid-soluble spore protein FOC77_RS09700 ENOG4108TGC Acyltransferase FOC77_RS09705 ENOG4105BZU Histidine kinase FOC77_RS09715 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC77_RS09730 ENOG4105BZU Histidine kinase FOC77_RS09735 ENOG41090MY MarR family Transcriptional regulator FOC77_RS09750 ENOG4108K88 Membrane FOC77_RS09780 ENOG4105KRI phosphocarrier protein (HPr FOC77_RS09785 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC77_RS09790 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOC77_RS09795 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC77_RS09800 ENOG4105CHM Aminotransferase FOC77_RS09810 ENOG41085PJ rdd domain containing protein FOC77_RS09820 ENOG4107R88 Chemotaxis protein (CheV) FOC77_RS09825 ENOG4105UIN FOC77_RS09830 ENOG4105BZU Histidine kinase FOC77_RS09840 ENOG4105EPM Diguanylate phosphodiesterase FOC77_RS09855 ENOG4107IN1 Protein of unknown function (DUF1797) FOC77_RS09875 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FOC77_RS09880 ENOG4105CH2 amidohydrolase FOC77_RS09890 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC77_RS09895 ENOG4107ZYR domain protein FOC77_RS09900 ENOG4105CN5 Metallo-Beta-Lactamase FOC77_RS09925 ENOG4105CPP Dehydrogenase, E1 component FOC77_RS09930 ENOG4105C7S Dehydrogenase FOC77_RS09950 ENOG4105CXN decarboxylase FOC77_RS09960 ENOG4108WQ8 UPF0637 protein FOC77_RS09970 ENOG4105ECY inositol monophosphatase FOC77_RS09975 ENOG4105CI3 gtp-binding protein typa FOC77_RS10000 ENOG4108IAB Phoh family FOC77_RS10015 ENOG4105CNI cell division protein FtsW FOC77_RS10020 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FOC77_RS10030 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC77_RS10060 ENOG4106H78 methyltransferase FOC77_RS10065 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FOC77_RS10070 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC77_RS10075 ENOG4105D78 K07001 NTE family protein FOC77_RS10080 ENOG4105CDE UPF0348 protein FOC77_RS10085 ENOG4105KNH Nucleic acid-binding protein FOC77_RS10095 ENOG4105EWC Purine nucleoside phosphorylase FOC77_RS10105 ENOG4107S3C Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC77_RS10115 ENOG41074B2 UPF0747 protein FOC77_RS10120 ENOG4108V6E Cell division protein mraZ FOC77_RS10135 ENOG4105CJN penicillin-binding protein FOC77_RS10145 ENOG4105CJN penicillin-binding protein FOC77_RS10150 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC77_RS10160 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FOC77_RS10165 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FOC77_RS10170 ENOG4105CNI cell division protein FtsW FOC77_RS10175 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC77_RS10180 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC77_RS10185 ENOG4108R2U division initiation protein FOC77_RS10195 ENOG4105K67 small basic protein FOC77_RS10200 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC77_RS10205 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC77_RS10210 ENOG4105FFI sigma-e processing peptidase spoiiga FOC77_RS10215 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC77_RS10225 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC77_RS10230 ENOG4105DFA alanine racemase domain protein FOC77_RS10235 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FOC77_RS10240 ENOG41067XK integral membrane protein FOC77_RS10245 ENOG4105DBK s4 domain protein FOC77_RS10255 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC77_RS10265 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FOC77_RS10270 ENOG4105C34 Pseudouridine synthase FOC77_RS10275 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FOC77_RS10285 ENOG4105CXT aspartate transcarbamylase FOC77_RS10290 ENOG4105CD3 dihydroorotase FOC77_RS10300 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FOC77_RS10310 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) FOC77_RS10335 ENOG4105DSJ YicC domain protein FOC77_RS10340 ENOG4105KC4 UPF0296 protein FOC77_RS10345 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FOC77_RS10355 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC77_RS10360 ENOG4105C25 Primosomal protein n' FOC77_RS10380 ENOG4105EG2 ABC transporter, permease FOC77_RS10405 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FOC77_RS10410 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC77_RS10415 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FOC77_RS10420 ENOG4108ZF3 Phosphatase FOC77_RS10425 ENOG4105D9P serine threonine protein kinase FOC77_RS10430 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC77_RS10435 ENOG4105FJ0 thiamine FOC77_RS10445 ENOG4105VB9 50S ribosomal protein l28 FOC77_RS10450 ENOG4108ZAA Alkaline-shock protein FOC77_RS10455 ENOG4105DP4 dak2 domain fusion protein ylov FOC77_RS10465 ENOG4105EJQ L-serine dehydratase FOC77_RS10470 ENOG4105CB5 ATP-dependent DNA helicase recG FOC77_RS10475 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) FOC77_RS10480 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FOC77_RS10485 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC77_RS10490 ENOG4105CHR reductase FOC77_RS10495 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FOC77_RS10500 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FOC77_RS10505 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC77_RS10510 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC77_RS10525 ENOG4105CJ1 ABC, transporter FOC77_RS10540 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC77_RS10575 ENOG4105K5M 30s ribosomal protein S16 FOC77_RS10580 ENOG4105VB6 UPF0109 protein FOC77_RS10590 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FOC77_RS10595 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FOC77_RS10605 ENOG4105C3F Signal peptidase i FOC77_RS10610 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC77_RS10625 ENOG4105VM1 flagellar FOC77_RS10630 ENOG4105CMV Succinyl-CoA synthetase subunit beta FOC77_RS10635 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC77_RS10640 ENOG4105C79 DNA protecting protein DprA FOC77_RS10645 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC77_RS10650 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC77_RS10655 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FOC77_RS10660 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FOC77_RS10665 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) FOC77_RS10670 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC77_RS10675 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC77_RS10680 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FOC77_RS10685 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FOC77_RS10690 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC77_RS10705 ENOG4106YF4 Flagellar biosynthesis chaperone FOC77_RS10720 ENOG410822I Flagellar hook capping protein FOC77_RS10730 ENOG4108JQA flagellar FOC77_RS10735 ENOG41068WV flagellar FlbD family protein FOC77_RS10745 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC77_RS10750 ENOG4105DD5 Flagellar motor switch protein FOC77_RS10755 ENOG4107YTP response regulator receiver protein FOC77_RS10765 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC77_RS10770 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC77_RS10775 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FOC77_RS10780 ENOG4105D00 flagellar biosynthetic protein flhB FOC77_RS10785 ENOG4105D7B Flagellar biosynthesis protein flha FOC77_RS10790 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC77_RS10800 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FOC77_RS10805 ENOG4105CBS Chea signal transduction histidine kinase FOC77_RS10810 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis FOC77_RS10820 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) FOC77_RS10825 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC77_RS10840 ENOG4105CE9 30S ribosomal protein S2 FOC77_RS10850 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC77_RS10855 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FOC77_RS10865 ENOG4105KNE Phosphatidate cytidylyltransferase FOC77_RS10870 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC77_RS10875 ENOG4105DZP Membrane-associated zinc metalloprotease FOC77_RS10885 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC77_RS10890 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FOC77_RS10895 ENOG4105CHV Transcription elongation factor NusA FOC77_RS10900 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC77_RS10905 ENOG4105VHM ribosomal protein FOC77_RS10910 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FOC77_RS10915 ENOG4105W7A Protein of unknown function (DUF503) FOC77_RS10925 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC77_RS10930 ENOG4105DTN riboflavin biosynthesis protein ribF FOC77_RS10935 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FOC77_RS10940 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FOC77_RS10950 ENOG4105C1V Peptidase, M16 FOC77_RS10955 ENOG4105E35 Dipicolinate synthase subunit A FOC77_RS10960 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC77_RS10965 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC77_RS10975 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC77_RS10990 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC77_RS11005 ENOG4105CNU cell division protein FtsK FOC77_RS11010 ENOG4105FDP GntR family transcriptional regulator FOC77_RS11015 ENOG4105DIH basic membrane FOC77_RS11020 ENOG4108JQ9 ABC transporter FOC77_RS11025 ENOG4105UIB (ABC) transporter FOC77_RS11050 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC77_RS11055 ENOG4105XZV Protein of unknown function (DUF3243) FOC77_RS11070 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC77_RS11075 ENOG4105CEV competence damage-inducible protein FOC77_RS11080 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FOC77_RS11085 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) FOC77_RS11090 ENOG4105D48 metallophosphoesterase FOC77_RS11095 ENOG4105MCT stage V sporulation protein S FOC77_RS11100 ENOG4108IGT Dipeptidase FOC77_RS11105 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC77_RS11135 ENOG4105X3H Excalibur domain protein FOC77_RS11140 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FOC77_RS11145 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FOC77_RS11185 ENOG4105EU9 FOC77_RS11195 ENOG4107T5V SNARE associated Golgi FOC77_RS11210 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC77_RS11215 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC77_RS11225 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC77_RS11230 ENOG4105DCM major facilitator superfamily FOC77_RS11235 ENOG410645S MarR family Transcriptional regulator FOC77_RS11275 ENOG4108QY0 Membrane FOC77_RS11290 ENOG41082JN Transcriptional regulator FOC77_RS11295 ENOG4108QY0 Membrane FOC77_RS11305 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOC77_RS11310 ENOG4108V4B ThiJ pfpI FOC77_RS11315 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC77_RS11320 ENOG4108VKI Cell wall hydrolase FOC77_RS11360 ENOG4105C0X amino acid FOC77_RS11380 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC77_RS11390 ENOG4108ZHR arsR family transcriptional regulator FOC77_RS11425 ENOG4105CVK Glutamate decarboxylase FOC77_RS11440 ENOG4107RF6 penicillin-binding protein FOC77_RS11445 ENOG4107RVG penicillin-binding protein FOC77_RS11450 ENOG4105NA0 Transcriptional regulator FOC77_RS11490 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold FOC77_RS11510 ENOG4105CHR reductase FOC77_RS11520 ENOG41086D8 Transcriptional regulator FOC77_RS11535 ENOG41068WN FOC77_RS11575 ENOG41060YP FOC77_RS11625 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC77_RS11635 ENOG4105CDY transcriptional regulatory protein FOC77_RS11640 ENOG4107TXC Transcriptional regulator FOC77_RS11680 ENOG4105CRK lysyL-tRNA synthetase FOC77_RS11690 ENOG4108UYN gCN5-related N-acetyltransferase FOC77_RS11720 ENOG41086D8 Transcriptional regulator FOC77_RS11735 ENOG4105KVH Transcriptional regulator FOC77_RS11740 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC77_RS11745 ENOG4108XXK NUDIX hydrolase FOC77_RS11750 ENOG4108UZ3 Transporter FOC77_RS11755 ENOG4108MCI Transcriptional regulator, ARAC family FOC77_RS11785 ENOG41081VB Hydrolase FOC77_RS11805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC77_RS11835 ENOG4105WAB arsR family transcriptional regulator FOC77_RS11840 ENOG4108RWP Major Facilitator Superfamily protein FOC77_RS11850 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC77_RS11855 ENOG4108IND Tetr family transcriptional regulator FOC77_RS11860 ENOG4105EQ0 Major Facilitator superfamily FOC77_RS11880 ENOG4105BZU Histidine kinase FOC77_RS11945 ENOG41086D8 Transcriptional regulator FOC77_RS11955 ENOG4105C75 arginyL-tRNA synthetase FOC77_RS11960 ENOG4105KTB nuclear export factor GLE1 FOC77_RS12000 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC77_RS12055 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FOC77_RS12090 ENOG4108JUA Transcriptional regulator FOC77_RS12095 ENOG4107RUY (E1 component), alpha subunit FOC77_RS12105 ENOG4107QKR Dehydrogenase FOC77_RS12115 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC77_RS12130 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FOC77_RS12140 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC77_RS12155 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC77_RS12160 ENOG4105DQ6 Transposase FOC77_RS12210 ENOG41080TC multidrug resistance protein FOC77_RS12215 ENOG4108RZE Tetr family transcriptional regulator FOC77_RS12265 ENOG4105EGI Transcriptional regulator FOC77_RS12300 ENOG4105BZU Histidine kinase FOC77_RS12370 ENOG410870W N-acetyltransferase FOC77_RS12395 ENOG4108U05 Transcriptional regulator FOC77_RS12400 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FOC77_RS12410 ENOG4108IYU L-aspartate oxidase FOC77_RS12415 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC77_RS12420 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FOC77_RS12435 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FOC77_RS12450 ENOG4106F1P AAA ATPase, central domain protein FOC77_RS12455 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC77_RS12460 ENOG4105CXI aluminum resistance protein FOC77_RS12465 ENOG4105KV4 Transcriptional regulator FOC77_RS12470 ENOG4105C5F glutamine synthetase FOC77_RS12505 ENOG4105KNA -acetyltransferase FOC77_RS12555 ENOG4108URH decarboxylase FOC77_RS12570 ENOG4105C7W Xanthine dehydrogenase FOC77_RS12580 ENOG4108XHQ (2Fe-2S)-binding domain protein FOC77_RS12595 ENOG4108UIN ybak prolyl-trna synthetase associated region FOC77_RS12600 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOC77_RS12610 ENOG4108SVB resolvase FOC77_RS12615 ENOG4105VPS UPF0291 protein FOC77_RS12660 ENOG4105BZ1 (ABC) transporter FOC77_RS12665 ENOG4105BZ1 (ABC) transporter FOC77_RS12675 ENOG4107QIV Cytochrome c biogenesis protein FOC77_RS12680 ENOG4107YTP response regulator receiver protein FOC77_RS12715 ENOG4105VEQ Cold shock protein FOC77_RS12720 ENOG4107RFY SbcCD D subunit FOC77_RS12725 ENOG4105EYH Exonuclease FOC77_RS12735 ENOG4105DER m42 family FOC77_RS12745 ENOG4105EEM helicase FOC77_RS12750 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FOC77_RS12770 ENOG4105KD7 acetyltransferase FOC77_RS12775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC77_RS12800 ENOG4105PGS Spore coat protein FOC77_RS12805 ENOG4105E2A Dehydrogenase FOC77_RS12850 ENOG4107DZX Small, acid-soluble spore protein P FOC77_RS12860 ENOG4108I0Z Aconitate hydratase FOC77_RS12865 ENOG4105WCN acetyltransferase FOC77_RS12880 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC77_RS12890 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FOC77_RS12900 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC77_RS12910 ENOG41075ZD Small, acid-soluble spore protein N FOC77_RS12915 ENOG4106F1P AAA ATPase, central domain protein FOC77_RS12930 ENOG4105MI2 FOC77_RS12935 ENOG4105W8X HesB YadR YfhF-family protein FOC77_RS12940 ENOG4105PNM synthesis protein FOC77_RS12945 ENOG4105BZU Histidine kinase FOC77_RS12950 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC77_RS12965 ENOG4105FDT acyl-CoA dehydrogenase FOC77_RS12975 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC77_RS12995 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC77_RS13025 ENOG4105C28 cystathionine FOC77_RS13030 ENOG4105C28 cystathionine FOC77_RS13035 ENOG41069DP small acid-soluble spore protein FOC77_RS13040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC77_RS13045 ENOG4105GR3 Histidine kinase FOC77_RS13050 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FOC77_RS13055 ENOG4105C7S Dehydrogenase FOC77_RS13070 ENOG4105WMR Protein CrcB homolog FOC77_RS13095 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC77_RS13110 ENOG4105F1A Pyruvate formate-lyase FOC77_RS13125 ENOG4105DZ1 carboxypeptidase FOC77_RS13130 ENOG4105C5H ABC transporter FOC77_RS13135 ENOG4108QTI )-transporter FOC77_RS13160 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC77_RS13175 ENOG4105BZU Histidine kinase FOC77_RS13180 ENOG41069ER domain protein FOC77_RS13195 ENOG4105XRQ Xanthine dehydrogenase accessory factor FOC77_RS13210 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FOC77_RS13215 ENOG4107YV9 domain protein FOC77_RS13220 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) FOC77_RS13225 ENOG4105VT2 5-hydroxyisourate hydrolase FOC77_RS13230 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) FOC77_RS13235 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FOC77_RS13255 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC77_RS13265 ENOG410667J hydrolase FOC77_RS13275 ENOG4105DPN Oligoendopeptidase f FOC77_RS13280 ENOG4105C5Q Transcriptional regulator FOC77_RS13285 ENOG4105CBC glutamate synthase FOC77_RS13290 ENOG4105BZ8 glutamate synthase FOC77_RS13305 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) FOC77_RS13310 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC77_RS13315 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC77_RS13320 ENOG4107TS3 membrane protein, TerC FOC77_RS13325 ENOG4108XRC Protein of unknown function (DUF458) FOC77_RS13350 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC77_RS13365 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC77_RS13380 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FOC77_RS13385 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOC77_RS13390 ENOG4108R6K riboflavin synthase, subunit alpha FOC77_RS13400 ENOG4105CGK Exodeoxyribonuclease III FOC77_RS13410 ENOG4105J7I hydrolase FOC77_RS13420 ENOG4105C1J atp-dependent rna helicase FOC77_RS13430 ENOG4105BZU Histidine kinase FOC77_RS13455 ENOG4105C19 ABC transporter FOC77_RS13470 ENOG4105YA8 Transcriptional regulator FOC77_RS13490 ENOG4105RHY Pfam:UPF0157 FOC77_RS13500 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FOC77_RS13510 ENOG4108B1Q Ribonuclease FOC77_RS13515 ENOG4108HRK Histidine kinase FOC77_RS13520 ENOG4105DY9 regulatoR FOC77_RS13530 ENOG4105BZU Histidine kinase FOC77_RS13535 ENOG4105CSV Glutaminase FOC77_RS13540 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC77_RS13550 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC77_RS13555 ENOG41067QW Transcriptional regulator FOC77_RS13575 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOC77_RS13705 ENOG4108M14 stage v sporulation protein t FOC77_RS13710 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FOC77_RS13745 ENOG4108UUM single-stranded DNA-binding protein FOC77_RS13815 ENOG4108TFU terminase (Small subunit) FOC77_RS13935 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC77_RS14000 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC77_RS14010 ENOG4105D5Q Arginine ornithine antiporter FOC77_RS14030 ENOG4105CD5 CoA-binding domain protein FOC77_RS14035 ENOG4105CH6 catalase FOC77_RS14040 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FOC77_RS14055 ENOG4105BZU Histidine kinase FOC77_RS14100 ENOG4108PJD permease FOC77_RS14115 ENOG4105C3M thioredoxin reductase FOC77_RS14120 ENOG4105ETE Transcriptional regulator (LacI family FOC77_RS14130 ENOG4105C5Y PTS System FOC77_RS14140 ENOG4105DUM transcriptional regulator, lysR family FOC77_RS14160 ENOG4105E98 transcriptional regulator DeoR family FOC77_RS14195 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC77_RS14215 ENOG4105CVJ phosphoglycerate mutase FOC77_RS14220 ENOG4107U9W Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) FOC77_RS14245 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC77_RS14250 ENOG4105K4P CoA-binding domain protein FOC77_RS14255 ENOG4105C8Q Methyl-accepting chemotaxis FOC77_RS14270 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FOC77_RS14280 ENOG41082JN Transcriptional regulator FOC77_RS14295 ENOG4108ZRV stage ii sporulation protein p FOC77_RS14300 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FOC77_RS14305 ENOG4105F6E Acyl-transferase FOC77_RS14310 ENOG410667J hydrolase FOC77_RS14315 ENOG4105E98 transcriptional regulator DeoR family FOC77_RS14330 ENOG4105DG6 mannose-6-phosphate isomerase FOC77_RS14335 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC77_RS14340 ENOG4105CZM Major Facilitator FOC77_RS14365 ENOG4105VKD bioY protein FOC77_RS14370 ENOG4108T5E Copper resistance protein FOC77_RS14390 ENOG4105DEN Luciferase family FOC77_RS14395 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FOC77_RS14405 ENOG4108X4Q Hydrolase FOC77_RS14415 ENOG4105SZ6 Thioredoxin FOC77_RS14420 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FOC77_RS14435 ENOG4107AYK membrAne FOC77_RS14440 ENOG4105EW9 transcriptional regulator AsnC family FOC77_RS14450 ENOG4105DR4 Methyltransferase FOC77_RS14460 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC77_RS14490 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FOC77_RS14495 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC77_RS14510 ENOG4105BZ1 (ABC) transporter FOC77_RS14515 ENOG4105DUM transcriptional regulator, lysR family FOC77_RS14520 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FOC77_RS14545 ENOG4105DDQ anthranilate synthase FOC77_RS14550 ENOG4105CRQ synthase (Component I) FOC77_RS14565 ENOG4105DM4 PTS System FOC77_RS14570 ENOG4105DE4 1-phosphofructokinase FOC77_RS14575 ENOG4105E98 transcriptional regulator DeoR family FOC77_RS14590 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC77_RS14615 ENOG4105DWF phosphomethylpyrimidine kinase FOC77_RS14630 ENOG4108PJD permease FOC77_RS14635 ENOG4105CKI cobalamin synthesis protein FOC77_RS14640 ENOG4105C8Q Methyl-accepting chemotaxis FOC77_RS14650 ENOG4107S1Q Phosphatase FOC77_RS14695 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FOC77_RS14730 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FOC77_RS14735 ENOG4105WDJ 50S ribosomal protein L33 FOC77_RS14740 ENOG4105CKI cobalamin synthesis protein FOC77_RS14785 ENOG4106YAD MORN repeat variant FOC77_RS14840 ENOG4105NX3 Membrane FOC77_RS14845 ENOG4105VMP Transcriptional regulator FOC77_RS14865 ENOG4105CZ9 Domain of unknown function (DU1801) FOC77_RS14870 ENOG4108ZMX Domain of unknown function (DU1801) FOC77_RS14900 ENOG4105DDN Pentapeptide repeat-containing protein FOC77_RS14920 ENOG4108TIT dATP pyrophosphohydrolase FOC77_RS14925 ENOG4105WG9 Conserved Protein FOC77_RS14930 ENOG4106BRA Membrane FOC77_RS14950 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC77_RS14970 ENOG4105E0Y RtcB Protein FOC77_RS14975 ENOG41090T1 Membrane FOC77_RS14990 ENOG4107T5V SNARE associated Golgi FOC77_RS14995 ENOG41068VA FOC77_RS15010 ENOG4105D9U N-acetyltransferase FOC77_RS15020 ENOG4105CVJ phosphoglycerate mutase FOC77_RS15025 ENOG41068WN FOC77_RS15055 ENOG4105KWG Pfam:DUF1696 FOC77_RS15075 ENOG4108ZJ4 polysaccharide deacetylase FOC77_RS15100 ENOG4105CMU LysR family (Transcriptional regulator FOC77_RS15105 ENOG4105VAW lrga family FOC77_RS15110 ENOG41067MG lrgb family FOC77_RS15130 ENOG4105VEQ Cold shock protein FOC77_RS15135 ENOG4105C1J atp-dependent rna helicase FOC77_RS15140 ENOG4105VEQ Cold shock protein FOC77_RS15145 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOC77_RS15150 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC77_RS15165 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC77_RS15170 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC77_RS15175 ENOG4105FDF Could be involved in DNA repair (By similarity) FOC77_RS15180 ENOG4105DQE DNA ligase FOC77_RS15190 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FOC77_RS15195 ENOG4105D58 Diguanylate phosphodiesterase FOC77_RS15225 ENOG4107R5R arsenical pump membrane protein FOC77_RS15230 ENOG41082YX Transcriptional regulator, arsr family FOC77_RS15235 ENOG4107QMU Mate efflux family protein FOC77_RS15255 ENOG4105K4I Scp-like extracellular FOC77_RS15270 ENOG4105CKI cobalamin synthesis protein FOC77_RS15280 ENOG4108VXD carboxy-peptidase FOC77_RS15310 ENOG4105VSD UPF0346 protein FOC77_RS15320 ENOG4105E0X reductase FOC77_RS15325 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC77_RS15345 ENOG41090WU lipolytic protein G-D-S-L family FOC77_RS15350 ENOG4105BZU Histidine kinase FOC77_RS15355 ENOG4108RCR degv family FOC77_RS15360 ENOG4105C7B Threonine dehydratase FOC77_RS15365 ENOG4108UT2 hemolysin iii FOC77_RS15370 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FOC77_RS15375 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FOC77_RS15385 ENOG4106FN3 tellurium resistance protein FOC77_RS15390 ENOG4108N0M stress protein FOC77_RS15400 ENOG4108TTB tellurium resistance protein FOC77_RS15410 ENOG4105DAX Pfam:DUF2983 FOC77_RS15425 ENOG4107TS3 membrane protein, TerC FOC77_RS15430 ENOG4106FN3 tellurium resistance protein FOC77_RS15440 ENOG4107YX5 Pfam:DUF548 FOC77_RS15455 ENOG4105C5H ABC transporter FOC77_RS15480 ENOG4108V06 Glutathione peroxidase FOC77_RS15490 ENOG4105CKU formyltetrahydrofolate synthetase FOC77_RS15495 ENOG4105CVG Homoserine O-transsuccinylase FOC77_RS15510 ENOG4105KST dependent repressor FOC77_RS15515 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC77_RS15520 ENOG4108QEG Membrane FOC77_RS15550 ENOG41081VK Ribonuclease FOC77_RS15580 ENOG4105CZV ABC transporter FOC77_RS15590 ENOG4105KHC sulfurtransferase FOC77_RS15595 ENOG410890F Dynamin family FOC77_RS15610 ENOG4105DVT helicase FOC77_RS15620 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC77_RS15630 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FOC77_RS15635 ENOG4106F55 Protein of unknown function (DUF1273) FOC77_RS15645 ENOG4107X2U Inherit from COG: Exonuclease-like protein FOC77_RS15650 ENOG4108I5C dEAD DEAH box helicase FOC77_RS15655 ENOG4108MUZ hydrolase FOC77_RS15660 ENOG4107Y70 Heat shock protein FOC77_RS15695 ENOG4105BZ4 penicillin-binding protein FOC77_RS15705 ENOG4105CSM endonuclease III FOC77_RS15715 ENOG4105C5S asparaginyl-tRNA synthetase FOC77_RS15720 ENOG4105CHM Aminotransferase FOC77_RS15730 ENOG4105DVT helicase FOC77_RS15735 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FOC77_RS15740 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FOC77_RS15755 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FOC77_RS15760 ENOG4105CPK Glycosyl transferase (Group 1 FOC77_RS15765 ENOG4105FJR Lmbe family FOC77_RS15770 ENOG4108Z5K methylglyoxal synthase FOC77_RS15775 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FOC77_RS15780 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC77_RS15785 ENOG4108JYZ YitT family FOC77_RS15795 ENOG4105EU0 Major facilitator Superfamily FOC77_RS15815 ENOG4108SXZ UPF0302 protein FOC77_RS15820 ENOG41068YB TPR repeat-containing protein FOC77_RS15830 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FOC77_RS15840 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC77_RS15845 ENOG4105KHN chorismate mutase FOC77_RS15850 ENOG4105D49 3-dehydroquinate synthase FOC77_RS15855 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC77_RS15860 ENOG4105BZU Histidine kinase FOC77_RS15865 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FOC77_RS15870 ENOG4105EAH synthase FOC77_RS15875 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC77_RS15880 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC77_RS15885 ENOG4105K70 DNA-binding protein FOC77_RS15890 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC77_RS15895 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FOC77_RS15900 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FOC77_RS15905 ENOG41065D1 FOC77_RS15910 ENOG4105S2F FOC77_RS15925 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FOC77_RS15945 ENOG4105MSI germination protein ypeb FOC77_RS15950 ENOG4105F0V Cell wall hydrolase FOC77_RS15960 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC77_RS15975 ENOG4107RGJ metallophosphoesterase FOC77_RS15990 ENOG4105WEF catalase FOC77_RS16005 ENOG4105I7S Abortive infection protein FOC77_RS16010 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC77_RS16015 ENOG4105T7X FOC77_RS16030 ENOG4108SAX Membrane FOC77_RS16035 ENOG4105DR5 peptidase FOC77_RS16055 ENOG4105BZU Histidine kinase FOC77_RS16060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC77_RS16065 ENOG4105FE9 pseudouridine synthase FOC77_RS16075 ENOG4108JIC nucleoside recognition domain protein FOC77_RS16080 ENOG4105DZ1 carboxypeptidase FOC77_RS16085 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC77_RS16090 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FOC77_RS16095 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FOC77_RS16110 ENOG4105PTM secreted protein FOC77_RS16125 ENOG4105G6R Stage v sporulation protein ae FOC77_RS16140 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC77_RS16145 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FOC77_RS16150 ENOG41082AN stage II sporulation protein FOC77_RS16155 ENOG4105DZ1 carboxypeptidase FOC77_RS16160 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC77_RS16165 ENOG4105JVQ RNA Polymerase FOC77_RS16185 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FOC77_RS16190 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC77_RS16200 ENOG4105I3K Ferric uptake regulator, Fur family FOC77_RS16205 ENOG4105MZ9 stage II sporulation protein m FOC77_RS16230 ENOG4105CPC Aldo Keto reductase FOC77_RS16245 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC77_RS16260 ENOG4107TVP HD domain protein FOC77_RS16310 ENOG4105EMN RNA polymerase sigma factor FOC77_RS16340 ENOG4108RVA ribokinase FOC77_RS16345 ENOG41067QW Transcriptional regulator FOC77_RS16375 ENOG4108X3M OsmC Ohr family protein FOC77_RS16410 ENOG4105X5K response regulator receiver protein FOC77_RS16420 ENOG4105C8Q Methyl-accepting chemotaxis FOC77_RS16425 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC77_RS16445 ENOG4108IXY short-chain dehydrogenase reductase FOC77_RS16455 ENOG4105II7 pyrroline-5-carboxylate reductase FOC77_RS16460 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC77_RS16465 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC77_RS16470 ENOG4107RN3 metallophosphoesterase FOC77_RS16480 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC77_RS16485 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC77_RS16495 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC77_RS16505 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC77_RS16510 ENOG4105CDA abc transporter atp-binding protein FOC77_RS16515 ENOG4105E5Q amino acid AbC transporter FOC77_RS16520 ENOG4108HW3 (ABC) transporter FOC77_RS16525 ENOG4108Y6J UPF0403 protein FOC77_RS16530 ENOG4105C7S Dehydrogenase FOC77_RS16535 ENOG4105CPP Dehydrogenase, E1 component FOC77_RS16550 ENOG4105CKM Branched-chain carboxylic acid kinase FOC77_RS16555 ENOG4108JUB Transcriptional regulator FOC77_RS16560 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC77_RS16610 ENOG4107QQR Sporulation FOC77_RS16615 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC77_RS16620 ENOG4105S1Z Stage IV sporulation protein B FOC77_RS16625 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC77_RS16630 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FOC77_RS16635 ENOG4105DX0 Hemolysin A FOC77_RS16640 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FOC77_RS16645 ENOG4105CTB Polyprenyl synthetase FOC77_RS16650 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOC77_RS16660 ENOG4105M7K Involved in the transcription termination process (By similarity) FOC77_RS16665 ENOG4108ZSR alkaline shock protein FOC77_RS16670 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC77_RS16690 ENOG410644B Stage III sporulation protein af FOC77_RS16700 ENOG4105KQ4 Stage iii sporulation protein ad FOC77_RS16705 ENOG4108CQH stage III sporulation protein AC FOC77_RS16710 ENOG4105KR5 Stage iii sporulation protein FOC77_RS16715 ENOG4105CD2 stage iii sporulation protein aa FOC77_RS16720 ENOG4105G6Z alkaline phosphatase FOC77_RS16730 ENOG4105CS2 ec 3.2.1.21 FOC77_RS16735 ENOG4105CJQ hydrolase, family 31 FOC77_RS16740 ENOG41066F8 ROK family FOC77_RS16750 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOC77_RS16770 ENOG4105EQD regulatoR FOC77_RS16775 ENOG4105C2F Histidine kinase FOC77_RS16790 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FOC77_RS16795 ENOG4105DC7 peptidase M24 FOC77_RS16805 ENOG4105CBJ Metal-dependent enzyme FOC77_RS16850 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC77_RS16855 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC77_RS16860 ENOG4105WZW rhodanese family FOC77_RS16865 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FOC77_RS16870 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FOC77_RS16875 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FOC77_RS16880 ENOG4105C0D helicase FOC77_RS16915 ENOG4106855 Competence protein FOC77_RS16935 ENOG4105PGM cation diffusion facilitator family transporter FOC77_RS16940 ENOG4105H3G oxidoreductase FOC77_RS16950 ENOG4105C5X domain protein FOC77_RS16970 ENOG4105E0M Sulfatase FOC77_RS16975 ENOG4105DKQ ROK family FOC77_RS16990 ENOG4107ZXI Rhomboid family FOC77_RS17010 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC77_RS17015 ENOG4105WDJ 50S ribosomal protein L33 FOC77_RS17045 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC77_RS17050 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC77_RS17055 ENOG4105E2Z phosphate ABC transporter (Permease FOC77_RS17060 ENOG4105C8U phosphate abc transporter FOC77_RS17065 ENOG4105CVA phosphate FOC77_RS17070 ENOG4107RF6 penicillin-binding protein FOC77_RS17075 ENOG4107RF6 penicillin-binding protein FOC77_RS17090 ENOG4107V6Q Cyclic nucleotide-binding domain FOC77_RS17095 ENOG4105SXS Protein of unknown function (DUF456) FOC77_RS17105 ENOG4105C8Q Methyl-accepting chemotaxis FOC77_RS17115 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FOC77_RS17125 ENOG4108U5J '-nucleotidase FOC77_RS17130 ENOG4105N80 Ferric uptake regulator, Fur family FOC77_RS17140 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FOC77_RS17155 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FOC77_RS17160 ENOG4105EGD dinuclear metal center protein, YbgI family FOC77_RS17175 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC77_RS17180 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC77_RS17185 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 FOC77_RS17190 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FOC77_RS17200 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FOC77_RS17205 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FOC77_RS17210 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) FOC77_RS17220 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC77_RS17230 ENOG4107YR5 Diacylglycerol kinase FOC77_RS17235 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FOC77_RS17240 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC77_RS17245 ENOG4105C9A Phoh family FOC77_RS17255 ENOG41068P3 sporulation protein YqfC FOC77_RS17265 ENOG4105DI5 UPF0365 protein FOC77_RS17270 ENOG4105F7J membrane-bound serine protease FOC77_RS17275 ENOG4105KTH gatB Yqey FOC77_RS17290 ENOG4105BZ1 (ABC) transporter FOC77_RS17295 ENOG4105BZ1 (ABC) transporter FOC77_RS17300 ENOG4106HBX Transcriptional Regulator AraC Family FOC77_RS17305 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FOC77_RS17310 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC77_RS17315 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC77_RS17320 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FOC77_RS17325 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOC77_RS17330 ENOG4105CFG Acts as a chaperone (By similarity) FOC77_RS17335 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC77_RS17340 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FOC77_RS17345 ENOG4105CSA Coproporphyrinogen iii oxidase FOC77_RS17350 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FOC77_RS17365 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FOC77_RS17370 ENOG4105TQK DNA polymerase iii, delta' subunit FOC77_RS17375 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC77_RS17380 ENOG4108UK2 deaminase FOC77_RS17385 ENOG4105KQC Competence protein FOC77_RS17395 ENOG4105DXX methyltransferase FOC77_RS17400 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FOC77_RS17405 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC77_RS17410 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FOC77_RS17415 ENOG410812S Rna-binding protein FOC77_RS17425 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC77_RS17430 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC77_RS17440 ENOG4105DJ4 phosphatidylserine decarboxylase FOC77_RS17445 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC77_RS17460 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC77_RS17480 ENOG4107Y5K Resolvase FOC77_RS17550 ENOG4105XSJ toxin secretion phage lysis holin FOC77_RS17645 ENOG4108TFU terminase (Small subunit) FOC77_RS17745 ENOG4108PNI recT protein FOC77_RS17750 ENOG4108NF7 phage-type endonuclease FOC77_RS17815 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC77_RS17820 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 FOC77_RS17840 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC77_RS17850 ENOG4107TXC Transcriptional regulator FOC77_RS17855 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOC77_RS17870 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) FOC77_RS17875 ENOG4105DBI uridine monophosphokinase FOC77_RS17885 ENOG4105C28 cystathionine FOC77_RS17895 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC77_RS17900 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC77_RS17915 ENOG4107XRG penicillin-binding protein FOC77_RS17920 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOC77_RS17925 ENOG4105DBI uridine monophosphokinase FOC77_RS17930 ENOG4105CFP Peptidase U32 FOC77_RS17935 ENOG4105XYU peptidase (U32 family) FOC77_RS17945 ENOG4105HHA aminodeoxychorismate lyase FOC77_RS17950 ENOG4105VPH UPF0473 protein FOC77_RS17960 ENOG4105VBH UPF0297 protein FOC77_RS17965 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC77_RS17970 ENOG4105C02 permease FOC77_RS17980 ENOG41060CR FOC77_RS17985 ENOG4105C7H Helicase, RecD TraA family FOC77_RS17995 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC77_RS18000 ENOG4105C3J Cysteine desulfurase FOC77_RS18025 ENOG4105DTQ mandelate racemase muconate lactonizing FOC77_RS18040 ENOG4105EG2 ABC transporter, permease FOC77_RS18055 ENOG4105D1H recombination factor protein RarA FOC77_RS18060 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC77_RS18065 ENOG4105CJ1 ABC, transporter FOC77_RS18070 ENOG4105CZV ABC transporter FOC77_RS18075 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC77_RS18085 ENOG4105CUZ uba thif-type nad fad binding protein FOC77_RS18090 ENOG4105C9M aspartyl-trna synthetase FOC77_RS18095 ENOG4105CUT histidyl-tRNA synthetase FOC77_RS18105 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC77_RS18115 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC77_RS18120 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FOC77_RS18125 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC77_RS18130 ENOG41067VP Protein of unknown function (DUF1049) FOC77_RS18135 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC77_RS18145 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC77_RS18150 ENOG4108QG2 Membrane FOC77_RS18155 ENOG4105NAP FOC77_RS18160 ENOG4105VIE preprotein translocase, subunit YajC FOC77_RS18170 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FOC77_RS18175 ENOG41061AI Protein of unknown function (DUF2905) FOC77_RS18185 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FOC77_RS18220 ENOG4105CQC Prephenate dehydratase FOC77_RS18225 ENOG41090I5 UPF0735 ACT domain-containing protein FOC77_RS18230 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC77_RS18240 ENOG4105K46 50S ribosomal protein l27 FOC77_RS18245 ENOG4105X36 (ribosomal) protein FOC77_RS18250 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FOC77_RS18255 ENOG4105C03 ribonuclease FOC77_RS18270 ENOG4107QMS site-determining protein FOC77_RS18275 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FOC77_RS18280 ENOG4105YHC Rod shape-determining protein MreD FOC77_RS18285 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC77_RS18290 ENOG4105DFF Rod shape-determining protein mreb FOC77_RS18295 ENOG4105W5Q DNA repair protein (RadC FOC77_RS18300 ENOG4108Z03 MAF-like protein FOC77_RS18310 ENOG4106855 Competence protein FOC77_RS18330 ENOG4106A3R peptidase FOC77_RS18345 ENOG4105CZX twitching motility protein FOC77_RS18350 ENOG4107QHF type ii secretion system protein e FOC77_RS18395 ENOG4105BZU Histidine kinase FOC77_RS18400 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC77_RS18405 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC77_RS18410 ENOG4106AR7 Spore coat protein FOC77_RS18415 ENOG41068KH stage VI sporulation protein D FOC77_RS18415 ENOG41068KH stage VI sporulation protein D FOC77_RS18420 ENOG4107BJW polysaccharide deacetylase FOC77_RS18430 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC77_RS18440 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FOC77_RS18445 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC77_RS18455 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FOC77_RS18465 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FOC77_RS18475 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FOC77_RS18480 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FOC77_RS18485 ENOG4108IUQ atp-dependent protease FOC77_RS18490 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FOC77_RS18495 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC77_RS18505 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC77_RS18510 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC77_RS18520 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FOC77_RS18525 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC77_RS18530 ENOG4108ZP8 Acetolactate synthase small subunit FOC77_RS18535 ENOG4105C7K acetolactate synthase FOC77_RS18545 ENOG4107KM7 Heat induced stress protein YflT FOC77_RS18560 ENOG4105M59 Phosphodiesterase, mj0936 family FOC77_RS18565 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC77_RS18575 ENOG4108XJQ germination protein FOC77_RS18580 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC77_RS18585 ENOG41067TZ transcriptional regulator, MarR family FOC77_RS18590 ENOG4105PFC Transcriptional regulator FOC77_RS18600 ENOG4105E33 succinate dehydrogenase FOC77_RS18610 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC77_RS18630 ENOG4105K63 Thioredoxin FOC77_RS18635 ENOG4105C10 Electron transfer flavoprotein FOC77_RS18640 ENOG4105BZJ Electron transfer flavoprotein FOC77_RS18645 ENOG4105CEY Amp-dependent synthetase and ligase FOC77_RS18655 ENOG4105C98 muts2 protein FOC77_RS18660 ENOG4105DCG PHP domain protein FOC77_RS18670 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FOC77_RS18675 ENOG41066F8 ROK family FOC77_RS18680 ENOG4105ETE Transcriptional regulator (LacI family FOC77_RS18685 ENOG4105DRS transport system, permease FOC77_RS18700 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC77_RS18705 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FOC77_RS18710 ENOG4108RWN rrna methyltransferase FOC77_RS18715 ENOG41067MF small acid-soluble spore protein FOC77_RS18720 ENOG4105CMG Carbohydrate kinase FOC77_RS18725 ENOG4105C93 Xylose Isomerase FOC77_RS18730 ENOG4105E2R ROK family FOC77_RS18735 ENOG4105C02 permease FOC77_RS18740 ENOG4105CN9 Peptidase m42 family protein FOC77_RS18755 ENOG410696E Membrane FOC77_RS18760 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FOC77_RS18770 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC77_RS18775 ENOG4105C22 threonyL-tRNA synthetase FOC77_RS18780 ENOG4108TDW sporulation protein YtxC FOC77_RS18795 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FOC77_RS18810 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC77_RS18815 ENOG4105C2M dna polymerase I FOC77_RS18820 ENOG4105BZU Histidine kinase FOC77_RS18825 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC77_RS18835 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC77_RS18840 ENOG4105BZN citrate synthase FOC77_RS18845 ENOG4108VMM UPF0756 membrane protein FOC77_RS18850 ENOG4108REF Sporulation integral membrane protein ytvi FOC77_RS18855 ENOG4107SET aldo keto reductase FOC77_RS18865 ENOG4105EK5 Glycoside hydrolase family 8 FOC77_RS18870 ENOG4105DMW Dehydrogenase reductase FOC77_RS18885 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOC77_RS18895 ENOG4107QNR UPF0135 protein FOC77_RS18900 ENOG4105MU9 integral membrane protein FOC77_RS18910 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FOC77_RS18915 ENOG4105XN3 extracellular solute-binding protein family 1 FOC77_RS18920 ENOG41075H3 AraC family transcriptional regulator FOC77_RS18925 ENOG4105C2F Histidine kinase FOC77_RS18930 ENOG4105FS0 cytoplasmic membrane protein FOC77_RS18935 ENOG4105CA9 Pyruvate kinase FOC77_RS18945 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FOC77_RS18950 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FOC77_RS18955 ENOG4107YCY Transcriptional regulator FOC77_RS18960 ENOG4105C0B DNA polymerase III (alpha subunit) FOC77_RS18965 ENOG4105VV2 FOC77_RS18975 ENOG4105SFS phosphoesterase RecJ domain protein FOC77_RS18990 ENOG4105DC7 peptidase M24 FOC77_RS19005 ENOG4107YZX Universal stress protein FOC77_RS19010 ENOG4105CH7 arginosuccinase FOC77_RS19015 ENOG4105CDH Citrulline--aspartate ligase FOC77_RS19020 ENOG4105EPU Molybdenum cofactor synthesis domain protein FOC77_RS19025 ENOG4105EEM helicase FOC77_RS19035 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC77_RS19045 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC77_RS19050 ENOG4105KBJ sporulation protein ytfj FOC77_RS19060 ENOG4105VK3 rdd domain containing protein FOC77_RS19065 ENOG4105D07 Signal peptide peptidase, SppA FOC77_RS19070 ENOG4105FR1 rard protein FOC77_RS19075 ENOG4105EFZ amidohydrolase FOC77_RS19080 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC77_RS19090 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FOC77_RS19100 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) FOC77_RS19105 ENOG4108W76 histidinol phosphate phosphatase hisj family FOC77_RS19110 ENOG4105U5Y Transcriptional regulator FOC77_RS19120 ENOG4105BZU Histidine kinase FOC77_RS19125 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FOC77_RS19145 ENOG4105ETE Transcriptional regulator (LacI family FOC77_RS19150 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC77_RS19155 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC77_RS19175 ENOG4105C88 aminopeptidase FOC77_RS19185 ENOG4105DFU Cell wall formation (By similarity) FOC77_RS19195 ENOG4108NKM UPF0354 protein FOC77_RS19220 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FOC77_RS19230 ENOG4108V15 phosphotransferase enzyme family FOC77_RS19235 ENOG4108IUM Glycogen debranching enzyme FOC77_RS19245 ENOG4107F58 2'-5' rna ligase FOC77_RS19255 ENOG4107QSE Dipeptidase FOC77_RS19260 ENOG4105E09 nadh pyrophosphatase FOC77_RS19265 ENOG4105YW5 deoR family transcriptional regulator FOC77_RS19280 ENOG4105CBX hi0933 family FOC77_RS19290 ENOG41085GJ domain protein FOC77_RS19295 ENOG4105C8T Leucyl-tRNA synthetase FOC77_RS19305 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) FOC77_RS19310 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC77_RS19315 ENOG4107TB6 phosphoglycerate mutase FOC77_RS19320 ENOG410605W Major Facilitator FOC77_RS19335 ENOG4105N5T Radical SAM Protein FOC77_RS19350 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC77_RS19360 ENOG4105CAQ asparagine synthetase FOC77_RS19365 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FOC77_RS19395 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC77_RS19405 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FOC77_RS19410 ENOG4108V2W Carbonate dehydratase FOC77_RS19425 ENOG4105CEY Amp-dependent synthetase and ligase FOC77_RS19430 ENOG4108IPT Naphthoate synthase FOC77_RS19435 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC77_RS19445 ENOG4105E4F Isochorismate synthase FOC77_RS19460 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC77_RS19605 ENOG4105KT7 mgtC SapB transporter FOC77_RS19625 ENOG4105BZU Histidine kinase FOC77_RS19635 ENOG41067CD Small, acid-soluble spore protein Tlp FOC77_RS19640 ENOG4105CIS alcohol dehydrogenase FOC77_RS19645 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC77_RS19650 ENOG4108DBC nitroreductase FOC77_RS19660 ENOG4105QVS general stress protein FOC77_RS19665 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC77_RS19680 ENOG4105CAH Chromate FOC77_RS19685 ENOG4105FGV Chromate FOC77_RS19690 ENOG4108UX3 '-nucleotidase FOC77_RS19695 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC77_RS19700 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOC77_RS19705 ENOG41067SE Tetr family transcriptional regulator FOC77_RS19710 ENOG4107PBV potassium channel FOC77_RS19725 ENOG4107QW4 alcohol dehydrogenase FOC77_RS19730 ENOG4105WG9 Conserved Protein FOC77_RS19735 ENOG4105C8Y Acetylornithine aminotransferase FOC77_RS19745 ENOG4105CHM Aminotransferase FOC77_RS19750 ENOG4108ZB6 transcriptional regulator AsnC family FOC77_RS19760 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC77_RS19765 ENOG4108UMI ABC transporter, permease FOC77_RS19770 ENOG4105D01 (LipO)protein FOC77_RS19780 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC77_RS19785 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC77_RS19805 ENOG4105D65 subunit l FOC77_RS19810 ENOG4105HC0 Na H antiporter FOC77_RS19815 ENOG4108ZE9 Monovalent cation H antiporter subunit C FOC77_RS19820 ENOG4108JPZ Monovalent cation H antiporter subunit D FOC77_RS19825 ENOG4105SC1 monovalent cation H antiporter subunit E FOC77_RS19835 ENOG4105KJM monovalent cation h antiporter subunit g FOC77_RS19870 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FOC77_RS19880 ENOG41069ER domain protein FOC77_RS19885 ENOG4105CAY ferredoxin--nadp reductase FOC77_RS19890 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC77_RS19900 ENOG4105ZKE UPF0349 protein FOC77_RS19915 ENOG41083MR nifu domain-containing protein FOC77_RS19925 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FOC77_RS19930 ENOG4105D6E homoserine dehydrogenase FOC77_RS19940 ENOG4108W5N phosphatidylglycerophosphatase a FOC77_RS19945 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC77_RS19955 ENOG4105BZU Histidine kinase FOC77_RS19960 ENOG4105MMD transcriptional regulator FOC77_RS19965 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FOC77_RS19970 ENOG4105FAA peptidase M23 FOC77_RS19975 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC77_RS19980 ENOG4105KZD Domain of unknown function (DUF1805) FOC77_RS19985 ENOG4107R8B 5'-nucleotidase FOC77_RS19990 ENOG4105I3N Conserved Protein FOC77_RS20000 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) FOC77_RS20015 ENOG4105J4Q Transcriptional regulator FOC77_RS20020 ENOG4108HCJ Hydrolase FOC77_RS20025 ENOG4108UW5 maltose o-acetyltransferase FOC77_RS20030 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC77_RS20040 ENOG4105DKQ ROK family FOC77_RS20045 ENOG4105DIW FeS assembly protein SUFB FOC77_RS20050 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC77_RS20055 ENOG4105C9B Cysteine desulfurase FOC77_RS20060 ENOG4105JRK feS assembly protein SufD FOC77_RS20065 ENOG4105C3K feS assembly ATPase SufC FOC77_RS20070 ENOG4105D01 (LipO)protein FOC77_RS20075 ENOG4108UMI ABC transporter, permease FOC77_RS20080 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC77_RS20100 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FOC77_RS20105 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC77_RS20110 ENOG4105C1G acyl-Coa dehydrogenase FOC77_RS20145 ENOG4105C8Q Methyl-accepting chemotaxis FOC77_RS20155 ENOG4105CDA abc transporter atp-binding protein FOC77_RS20160 ENOG4105DRP amino acid AbC transporter FOC77_RS20180 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC77_RS20185 ENOG4106F5Q Membrane FOC77_RS20190 ENOG4105EYF MMPL domain protein FOC77_RS20195 ENOG41067TZ transcriptional regulator, MarR family FOC77_RS20200 ENOG4105KA0 thioesterase Superfamily protein FOC77_RS20215 ENOG4105FKQ transcriptional regulator FOC77_RS20220 ENOG4105KVH Transcriptional regulator FOC77_RS20225 ENOG4108VA3 3-hexulose-6-phosphate synthase FOC77_RS20230 ENOG41080HJ 6-phospho 3-hexuloisomerase FOC77_RS20250 ENOG4105C5H ABC transporter FOC77_RS20260 ENOG4105ETE Transcriptional regulator (LacI family FOC77_RS20265 ENOG4105DDC Oxidoreductase domain protein FOC77_RS20275 ENOG4105F5H Glycosyl Hydrolase Family 88 FOC77_RS20280 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FOC77_RS20285 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC77_RS20290 ENOG410769Z extracellular solute-binding protein family 1 FOC77_RS20295 ENOG4105EQD regulatoR FOC77_RS20300 ENOG4105C2F Histidine kinase FOC77_RS20310 ENOG4105MU9 integral membrane protein FOC77_RS20325 ENOG4107MMM Anti-sigma-factor antagonist FOC77_RS20345 ENOG4105FF2 Type I DHQase FOC77_RS20350 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOC77_RS20365 ENOG4105DRS transport system, permease FOC77_RS20370 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC77_RS20375 ENOG4107YY3 extracellular solute-binding protein family 1 FOC77_RS20385 ENOG4108K2B transcriptional regulator FOC77_RS20390 ENOG4105C59 p-type ATPase FOC77_RS20395 ENOG410681U heavy metal transport detoxification protein FOC77_RS20405 ENOG4105DRR Transcriptional regulator, GntR family FOC77_RS20420 ENOG4107TXC Transcriptional regulator FOC77_RS20425 ENOG4108TZY GntR Family Transcriptional Regulator FOC77_RS20430 ENOG4107ZXU DSBA oxidoreductase FOC77_RS20450 ENOG4107XGZ Hydrolase FOC77_RS20465 ENOG4105ECW sulfate abc transporter FOC77_RS20470 ENOG4108I5D sulfate abc transporter FOC77_RS20475 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FOC77_RS20485 ENOG4105EAB amino acid AbC transporter FOC77_RS20490 ENOG4105DRP amino acid AbC transporter FOC77_RS20495 ENOG4105CDA abc transporter atp-binding protein FOC77_RS20515 ENOG4106UIA FOC77_RS20535 ENOG4105C26 Dehydrogenase FOC77_RS20545 ENOG4105CPQ Dehydrogenase FOC77_RS20550 ENOG4105DT3 PTS system, galactitol-specific IIc component FOC77_RS20560 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FOC77_RS20565 ENOG4105EMD TRANSCRIPTIONal FOC77_RS20575 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FOC77_RS20580 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC77_RS20590 ENOG4105XZU Preprotein translocase, subunit SecG FOC77_RS20600 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC77_RS20630 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC77_RS20635 ENOG4105KRI phosphocarrier protein (HPr FOC77_RS20645 ENOG4105CHW UPF0052 protein FOC77_RS20650 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FOC77_RS20655 ENOG4108Z4K mutator MutT protein FOC77_RS20665 ENOG4105C3M thioredoxin reductase FOC77_RS20675 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FOC77_RS20680 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FOC77_RS20685 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FOC77_RS20690 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOC77_RS20695 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOC77_RS20700 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC77_RS20705 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOC77_RS20710 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FOC77_RS20715 ENOG4108S4C acetyltransferase FOC77_RS20720 ENOG4107XGZ Hydrolase FOC77_RS20730 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FOC77_RS20735 ENOG41086DT Membrane protein of unknown function FOC77_RS20740 ENOG4108PY7 FOC77_RS20745 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC77_RS20750 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC77_RS20775 ENOG4105C0A alcohol dehydrogenase FOC77_RS20785 ENOG4105EYF MMPL domain protein FOC77_RS20790 ENOG4105JVQ RNA Polymerase FOC77_RS20795 ENOG4108P49 AntiSigma factor FOC77_RS20815 ENOG4105C5R Aminotransferase FOC77_RS20820 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FOC77_RS20825 ENOG4105G9B Transcriptional regulator FOC77_RS20835 ENOG4105C6K Malic enzyme FOC77_RS20840 ENOG4105E66 phosphoriboisomerase A FOC77_RS20860 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) FOC77_RS20870 ENOG4107EFR Flavocytochrome c FOC77_RS20875 ENOG4108ZMQ domain protein FOC77_RS20880 ENOG4105VUF Transcriptional regulator FOC77_RS20885 ENOG4105DQ4 alcohol dehydrogenase FOC77_RS20890 ENOG4108JJ8 (ABC) transporter FOC77_RS20895 ENOG4108JJ9 ABC, transporter FOC77_RS20915 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOC77_RS20920 ENOG4105CTQ phosphohexokinase FOC77_RS20925 ENOG4108YZG isomerase FOC77_RS20935 ENOG4105CPQ Dehydrogenase FOC77_RS20940 ENOG4105DT3 PTS system, galactitol-specific IIc component FOC77_RS20945 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FOC77_RS20950 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FOC77_RS20960 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FOC77_RS20965 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOC77_RS20970 ENOG4105CTQ phosphohexokinase FOC77_RS20975 ENOG4108YZG isomerase FOC77_RS20985 ENOG4105CV8 reductase FOC77_RS20990 ENOG4105F27 Major Facilitator FOC77_RS20995 ENOG4105KVH Transcriptional regulator FOC77_RS21005 ENOG4105CN1 protease FOC77_RS21015 ENOG4105C59 p-type ATPase FOC77_RS21020 ENOG4105KTU Transcriptional regulator, arsr family FOC77_RS21030 ENOG4108RS6 transposase FOC77_RS21035 ENOG4105DR5 peptidase FOC77_RS21040 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC77_RS21045 ENOG4105CAK Cell division ATP-binding protein ftsE FOC77_RS21080 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC77_RS21100 ENOG4108I5D sulfate abc transporter FOC77_RS21105 ENOG4105F38 ABC transporter, permease FOC77_RS21110 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC77_RS21125 ENOG4107XBN GntR Family Transcriptional Regulator FOC77_RS21135 ENOG4105FGV Chromate FOC77_RS21140 ENOG4105CAH Chromate FOC77_RS21145 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC77_RS21170 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC77_RS21180 ENOG4105MQ3 flagellar protein FliS FOC77_RS21185 ENOG4107RT6 flagellar hook-associated FOC77_RS21195 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOC77_RS21200 ENOG4105C1B dTDP-glucose 4-6-dehydratase FOC77_RS21205 ENOG4105D2T synthase FOC77_RS21225 ENOG4105CHR reductase FOC77_RS21235 ENOG4107TY6 Acylneuraminate cytidylyltransferase FOC77_RS21250 ENOG4105X1N Glycosyl transferase family 8 FOC77_RS21270 ENOG4105C5E polysaccharide biosynthesis protein FOC77_RS21280 ENOG4105I03 Flagellin FOC77_RS21285 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FOC77_RS21290 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) FOC77_RS21295 ENOG4105DTJ flagellar hook-associated protein FOC77_RS21300 ENOG4105E1Q flagellar hook-associated protein FOC77_RS21315 ENOG4105XVJ Protein of unknown function (DUF327) FOC77_RS21325 ENOG4105MQ3 flagellar protein FliS FOC77_RS21345 ENOG41081UC Inherit from COG: Competence protein FOC77_RS21370 ENOG4105WH1 Two component transcriptional regulator luxr family FOC77_RS21375 ENOG4105BZU Histidine kinase FOC77_RS21380 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC77_RS21385 ENOG4108KGH TRANSCRIPTIONal FOC77_RS21395 ENOG4105JFG SpoIID LytB domain protein FOC77_RS21400 ENOG4105ESV Glycosyl transferase, family 4 FOC77_RS21405 ENOG4105EY8 ABC transporter FOC77_RS21420 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase FOC77_RS21425 ENOG4107RZX Teichoic acid biosynthesis protein FOC77_RS21430 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOC77_RS21450 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC77_RS21455 ENOG4105CMR udp-glucose 4-epimerase FOC77_RS21460 ENOG4107T9C Alpha amylase catalytic region FOC77_RS21465 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family FOC77_RS21480 ENOG4105Z8H single-stranded DNA-binding protein FOC77_RS21490 ENOG4105Q95 Cupin 2, conserved barrel domain protein FOC77_RS21495 ENOG4105EC8 Methyl-accepting chemotaxis FOC77_RS21500 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC77_RS21505 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC77_RS21515 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC77_RS21530 ENOG4105C26 Dehydrogenase FOC77_RS21560 ENOG4105I1F Resistance protein FOC77_RS21565 ENOG4107SCQ Iron-containing alcohol dehydrogenase FOC77_RS21570 ENOG4106KE4 Dehydrogenase FOC77_RS21575 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC77_RS21580 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FOC77_RS21585 ENOG4105FTQ Dna gyrase FOC77_RS21610 ENOG4105D9N nucleoside FOC77_RS21620 ENOG4105D01 (LipO)protein FOC77_RS21625 ENOG4108UMI ABC transporter, permease FOC77_RS21630 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC77_RS21640 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FOC77_RS21650 ENOG4105CJZ response regulator FOC77_RS21655 ENOG4105EWM Histidine kinase FOC77_RS21660 ENOG4105C19 ABC transporter FOC77_RS21685 ENOG4105C87 Aminotransferase class I and II FOC77_RS21690 ENOG4105BZU Histidine kinase FOC77_RS21725 ENOG4108TVJ Nitroreductase FOC77_RS21740 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC77_RS21750 ENOG4108K4B hydrolase FOC77_RS21775 ENOG4105DPN Oligoendopeptidase f FOC77_RS21780 ENOG4105CS2 ec 3.2.1.21 FOC77_RS21785 ENOG4108S3Y transcriptional regulator FOC77_RS21795 ENOG4105EC8 Methyl-accepting chemotaxis FOC77_RS21810 ENOG4105K7K Transcriptional regulator FOC77_RS21820 ENOG4105D2N Aldolase FOC77_RS21825 ENOG4105DM4 PTS System FOC77_RS21830 ENOG4108YRF PTS System FOC77_RS21845 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC77_RS21865 ENOG4107E6A Cytochrome p-450 FOC77_RS21870 ENOG4107JEE Short-chain dehydrogenase reductase Sdr FOC77_RS21875 ENOG4105EQ0 Major Facilitator superfamily FOC77_RS21880 ENOG4105C8I hydrolase, family 38 FOC77_RS21900 ENOG4105EQD regulatoR FOC77_RS21905 ENOG4105C2F Histidine kinase FOC77_RS21920 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOC77_RS21930 ENOG4105CF7 AraC family transcriptional regulator FOC77_RS21935 ENOG4105CHR reductase FOC77_RS21940 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC77_RS21945 ENOG4105J7D transcriptional regulator FOC77_RS21955 ENOG4108RCM Nitroreductase FOC77_RS21960 ENOG4105EQD regulatoR FOC77_RS21965 ENOG4105C2F Histidine kinase FOC77_RS21980 ENOG4105EK5 Glycoside hydrolase family 8 FOC77_RS21985 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOC77_RS22000 ENOG4105FDP GntR family transcriptional regulator FOC77_RS22005 ENOG4105CXK mandelate racemase muconate lactonizing FOC77_RS22010 ENOG4105C5Y PTS System FOC77_RS22025 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC77_RS22030 ENOG4105C4Y ABC transporter FOC77_RS22035 ENOG4107VQW regulatoR FOC77_RS22045 ENOG4105C5Y PTS System FOC77_RS22055 ENOG4106XGU FOC77_RS22060 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FOC77_RS22065 ENOG4105BZW Glycerate kinase FOC77_RS22070 ENOG4107QQ0 gntp family FOC77_RS22090 ENOG4105F38 ABC transporter, permease FOC77_RS22095 ENOG4105F38 ABC transporter, permease FOC77_RS22100 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC77_RS22105 ENOG4105CPN adenine deaminase FOC77_RS22120 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC77_RS22125 ENOG4105CS2 ec 3.2.1.21 FOC77_RS22130 ENOG4105CS2 ec 3.2.1.21 FOC77_RS22135 ENOG4105C5Y PTS System FOC77_RS22150 ENOG4105DQ5 transport system permease protein FOC77_RS22155 ENOG4105EHG Permease protein FOC77_RS22160 ENOG4105WH1 Two component transcriptional regulator luxr family FOC77_RS22165 ENOG4108KMM Diguanylate cyclase FOC77_RS22170 ENOG4105DY9 regulatoR FOC77_RS22180 ENOG4108W8B Beta-lactamase domain protein FOC77_RS22205 ENOG4105D2N Aldolase FOC77_RS22225 ENOG4106ETB IIa component FOC77_RS22230 ENOG4105DEN Luciferase family FOC77_RS22240 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC77_RS22245 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC77_RS22265 ENOG4108KGH TRANSCRIPTIONal FOC77_RS22275 ENOG4105K4I Scp-like extracellular FOC77_RS22300 ENOG4107YB6 acetyltransferase, (GNAT) family FOC77_RS22310 ENOG4105CK1 PTS System FOC77_RS22315 ENOG4105VCP PTS System FOC77_RS22325 ENOG4105CK1 PTS System FOC77_RS22330 ENOG4105CS2 ec 3.2.1.21 FOC77_RS22335 ENOG4108TZY GntR Family Transcriptional Regulator FOC77_RS22370 ENOG4105DRS transport system, permease FOC77_RS22375 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC77_RS22385 ENOG4105E2R ROK family FOC77_RS22405 ENOG41073R8 VanW family FOC77_RS22410 ENOG4105CNN ABC, transporter FOC77_RS22415 ENOG4105C2J ABC transporter FOC77_RS22420 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC77_RS22425 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOC77_RS22430 ENOG4105ETE Transcriptional regulator (LacI family FOC77_RS22460 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) FOC77_RS22480 ENOG4105C19 ABC transporter FOC77_RS22485 ENOG4108HVR ABC transporter, permease FOC77_RS22495 ENOG4105CMD Transcriptional regulator, GntR family FOC77_RS22510 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FOC77_RS22555 ENOG4108NEV two component transcriptional regulator, LytTR family FOC77_RS22565 ENOG4108PGP mmge prpd family protein FOC77_RS22580 ENOG4108HW4 amino acid AbC transporter FOC77_RS22585 ENOG4105EAB amino acid AbC transporter FOC77_RS22595 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FOC77_RS22600 ENOG4105EAB amino acid AbC transporter FOC77_RS22610 ENOG4107SCQ Iron-containing alcohol dehydrogenase FOC77_RS22640 ENOG41061AU MarR family Transcriptional regulator FOC77_RS22650 ENOG4105DXB Major Facilitator superfamily FOC77_RS22655 ENOG4105DRS transport system, permease FOC77_RS22660 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC77_RS22670 ENOG4106IQC argininosuccinate lyase FOC77_RS22680 ENOG4105E2R ROK family FOC77_RS22695 ENOG4105C8Q Methyl-accepting chemotaxis FOC77_RS22700 ENOG4105CK1 PTS System FOC77_RS22710 ENOG4105D9R oxidoreductase FOC77_RS22720 ENOG4105VCP PTS System FOC77_RS22725 ENOG4105VZJ PTS System FOC77_RS22730 ENOG4105EMD TRANSCRIPTIONal FOC77_RS22740 ENOG4105C26 Dehydrogenase FOC77_RS22755 ENOG4105BZU Histidine kinase FOC77_RS22760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC77_RS22765 ENOG4108RTU Aldolase FOC77_RS22770 ENOG4108JQ1 Dehydrogenase FOC77_RS22775 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 FOC77_RS22780 ENOG4105C5I Dehydrogenase FOC77_RS22785 ENOG4105DAS pts system FOC77_RS22825 ENOG4105BZU Histidine kinase FOC77_RS22865 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC77_RS22870 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC77_RS22890 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC77_RS22895 ENOG4105F3R pts system mannose fructose sorbose family iid FOC77_RS22900 ENOG4105ETZ PTS System FOC77_RS22905 ENOG4105KPI PTS system sorbose subfamily IIB component FOC77_RS22910 ENOG4105DAS pts system FOC77_RS22915 ENOG4105E2R ROK family FOC77_RS22920 ENOG4108SU4 UPF0309 protein FOC77_RS22930 ENOG4107W9I Creatinine amidohydrolase FOC77_RS22940 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FOC77_RS22955 ENOG4106ETB IIa component FOC77_RS22970 ENOG4105DZC cytosine deaminase FOC77_RS22975 ENOG4105DZC cytosine deaminase FOC77_RS22985 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC77_RS23005 ENOG4105DJB Major Facilitator Superfamily FOC77_RS23010 ENOG4105CXK mandelate racemase muconate lactonizing FOC77_RS23015 ENOG4108UHU Aldolase FOC77_RS23020 ENOG4105D7K pfkb domain protein FOC77_RS23025 ENOG4105J4Q Transcriptional regulator FOC77_RS23045 ENOG4105C5Y PTS System FOC77_RS23050 ENOG4105CID antiterminator FOC77_RS23075 ENOG4105C5Y PTS System FOC77_RS23095 ENOG4105E2R ROK family FOC77_RS23100 ENOG4105DKQ ROK family FOC77_RS23110 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FOC77_RS23115 ENOG4108SU4 UPF0309 protein FOC77_RS23125 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain FOC77_RS23135 ENOG4108M26 parallel beta-helix repeat protein FOC77_RS23160 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FOC77_RS23165 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FOC77_RS23170 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FOC77_RS23180 ENOG4107RGD Major Facilitator superfamily FOC77_RS23190 ENOG4107TT2 Auxin Efflux Carrier FOC77_RS23195 ENOG4105C6K Malic enzyme FOC77_RS23215 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FOC77_RS23225 ENOG4105CI1 PTS System FOC77_RS23230 ENOG4108RVA ribokinase FOC77_RS23235 ENOG4105DJV ribulose-phosphate 3-epimerase FOC77_RS23240 ENOG4105ETE Transcriptional regulator (LacI family FOC77_RS23270 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC77_RS23275 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FOC77_RS23285 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FOC77_RS23320 ENOG4105D3Q Sugar transferase FOC77_RS23325 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC77_RS23330 ENOG4107YJ4 chain length determinant protein FOC77_RS23335 ENOG4105HTX biosynthesis protein FOC77_RS23345 ENOG4108IMY Transcriptional regulator FOC77_RS23370 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FOC77_RS23375 ENOG4105BZ1 (ABC) transporter FOC77_RS23395 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FOC77_RS23400 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FOC77_RS23435 ENOG4105C0K Gdp-mannose 4,6-dehydratase FOC77_RS23440 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FOC77_RS23450 ENOG4107STW synthase FOC77_RS23460 ENOG4108SHN Glycosyl transferase, family 2 FOC77_RS23465 ENOG4105D3Q Sugar transferase FOC77_RS23470 ENOG4107YJ4 chain length determinant protein FOC77_RS23475 ENOG4105HTX biosynthesis protein FOC77_RS23480 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC77_RS23485 ENOG4105D64 Mechanosensitive ion channel FOC77_RS23525 ENOG4105K56 Transcriptional regulator FOC77_RS23530 ENOG4105BZ1 (ABC) transporter FOC77_RS23560 ENOG4105KRN Transcriptional regulator, abrb family FOC77_RS23565 ENOG4106KTS Inner membrane protein yeaI FOC77_RS23570 ENOG4105KK4 UPF0060 membrane protein FOC77_RS23585 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC77_RS23590 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FOC77_RS23595 ENOG4105CW7 secretion protein, HlyD family FOC77_RS23600 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC77_RS23625 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FOC77_RS23630 ENOG4105YA8 Transcriptional regulator FOC77_RS23655 ENOG4105DRS transport system, permease FOC77_RS23660 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FOC77_RS23675 ENOG4105UQX Mate efflux family protein FOC77_RS23680 ENOG4105DFY n-acylglucosamine 2-epimerase FOC77_RS23690 ENOG4105CPC Aldo Keto reductase FOC77_RS23695 ENOG41066F8 ROK family FOC77_RS23700 ENOG4105CS2 ec 3.2.1.21 FOC77_RS23710 ENOG4105I82 acetyl xylan esterase FOC77_RS23715 ENOG4105CMD Transcriptional regulator, GntR family FOC77_RS23720 ENOG4107S21 permease FOC77_RS23730 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) FOC77_RS23745 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC77_RS23750 ENOG41090UD (LipO)protein FOC77_RS23755 ENOG4105BZU Histidine kinase FOC77_RS23760 ENOG4105EEQ Na H antiporter FOC77_RS23770 ENOG4108Z7F N-acetyltransferase FOC77_RS23815 ENOG4105BZU Histidine kinase FOC77_RS23820 ENOG4105KCT ABC transporter FOC77_RS23825 ENOG4108M15 ABC transporter FOC77_RS23850 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC77_RS23855 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC77_RS23870 ENOG4105K4H Nlp p60 protein FOC77_RS23875 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC77_RS23890 ENOG4105D6E homoserine dehydrogenase FOC77_RS23895 ENOG4105EMN RNA polymerase sigma factor FOC77_RS23900 ENOG4105J37 FOC77_RS23905 ENOG4105ED1 spovr family FOC77_RS23910 ENOG4107RVG penicillin-binding protein FOC77_RS23915 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FOC77_RS23935 ENOG4105KBK Zinc finger, swim domain protein FOC77_RS23940 ENOG4105C0D helicase FOC77_RS23970 ENOG4105CGA flagellar basal-body rod protein FlgG FOC77_RS23980 ENOG4105DFF Rod shape-determining protein mreb FOC77_RS23985 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC77_RS23990 ENOG4105FRN stage II sporulation protein FOC77_RS24000 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC77_RS24010 ENOG4106778 Protein of unknown function (DUF1146) FOC77_RS24015 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FOC77_RS24020 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FOC77_RS24025 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FOC77_RS24035 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOC77_RS24045 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOC77_RS24050 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC77_RS24055 ENOG41062M3 atp synthase FOC77_RS24060 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC77_RS24065 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FOC77_RS24070 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOC77_RS24075 ENOG4108UIC UPF0340 protein FOC77_RS24080 ENOG4105C8Q Methyl-accepting chemotaxis FOC77_RS24090 ENOG410815N Probably functions as a manganese efflux pump (By similarity) FOC77_RS24095 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC77_RS24115 ENOG4105C26 Dehydrogenase FOC77_RS24125 ENOG4105CC5 ABC transporter FOC77_RS24130 ENOG4105CC5 ABC transporter FOC77_RS24135 ENOG4105DIK (ABC) transporter FOC77_RS24140 ENOG4105DSE periplasmic solute binding protein FOC77_RS24145 ENOG4108ZXQ stage ii sporulation protein r FOC77_RS24150 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC77_RS24155 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC77_RS24160 ENOG4106SCS STAS domain FOC77_RS24165 ENOG4105C37 (CBS) domain FOC77_RS24170 ENOG4105C37 (CBS) domain FOC77_RS24180 ENOG4107104 thymidine kinase FOC77_RS24185 ENOG4105VFB Binds the 23S rRNA (By similarity) FOC77_RS24190 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC77_RS24195 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC77_RS24200 ENOG4105D2N Aldolase FOC77_RS24205 ENOG410812K response regulator receiver protein FOC77_RS24215 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOC77_RS24235 ENOG4107Y7X LytTR FOC77_RS24240 ENOG4108IUW ABC transporter FOC77_RS24245 ENOG4108SDH ABC, transporter FOC77_RS24260 ENOG4105DA5 (ABC) transporter FOC77_RS24285 ENOG4105C75 arginyL-tRNA synthetase FOC77_RS24290 ENOG410684U Domain of unknown function (DUF1934) FOC77_RS24300 ENOG4105CYW agmatinase FOC77_RS24305 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC77_RS24310 ENOG4105BZ4 penicillin-binding protein FOC77_RS24315 ENOG4105C98 muts2 protein FOC77_RS24320 ENOG4108XFG YwhD family FOC77_RS24325 ENOG4108Z4T Peptidase M50 FOC77_RS24330 ENOG41069HH 4-oxalocrotonate tautomerase FOC77_RS24340 ENOG4105DCI Phosphohydrolase FOC77_RS24350 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC77_RS24355 ENOG4108VCI transcription factor, rsfa family FOC77_RS24360 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FOC77_RS24365 ENOG4108IJ2 phosphate acetyltransferase FOC77_RS24370 ENOG4107JTW chlorite dismutase FOC77_RS24395 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FOC77_RS24410 ENOG4105D06 uba thif-type nad fad binding protein FOC77_RS24415 ENOG41067WU Molybdopterin converting factor (Subunit 1) FOC77_RS24420 ENOG4108ZAF Molybdopterin FOC77_RS24425 ENOG4105DWF phosphomethylpyrimidine kinase FOC77_RS24435 ENOG4108TN2 lmbE family FOC77_RS24450 ENOG4105CJ1 ABC, transporter FOC77_RS24465 ENOG4105J7I hydrolase FOC77_RS24470 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC77_RS24475 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC77_RS24480 ENOG4108JJ9 ABC, transporter FOC77_RS24485 ENOG4108JJ8 (ABC) transporter FOC77_RS24490 ENOG4108Z66 YbaK ebsC protein FOC77_RS24505 ENOG4105F8D glycoside hydrolase family 4 FOC77_RS24515 ENOG4105DWK Membrane FOC77_RS24535 ENOG4105CJ1 ABC, transporter FOC77_RS24540 ENOG4105DCF alanine dehydrogenase FOC77_RS24545 ENOG4108K8K Transcriptional regulator FOC77_RS24555 ENOG4105F8D glycoside hydrolase family 4 FOC77_RS24560 ENOG4105VCP PTS System FOC77_RS24565 ENOG4105CK1 PTS System FOC77_RS24570 ENOG4105VZJ PTS System FOC77_RS24585 ENOG4105D2X ABC transporter substrate-binding protein FOC77_RS24590 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC77_RS24605 ENOG4105VCP PTS System FOC77_RS24610 ENOG4105VZJ PTS System FOC77_RS24615 ENOG4105CS2 ec 3.2.1.21 FOC77_RS24620 ENOG4105CK1 PTS System FOC77_RS24625 ENOG4105EMD TRANSCRIPTIONal FOC77_RS24635 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC77_RS24685 ENOG4105G9B Transcriptional regulator FOC77_RS24695 ENOG41079KZ Major Facilitator Superfamily FOC77_RS24700 ENOG4105UQX Mate efflux family protein FOC77_RS24710 ENOG4105D7K pfkb domain protein FOC77_RS24730 ENOG41080HJ 6-phospho 3-hexuloisomerase FOC77_RS24735 ENOG4105FKQ transcriptional regulator FOC77_RS24745 ENOG4107URF beta-phospho-glucomutase FOC77_RS24760 ENOG4105EG2 ABC transporter, permease FOC77_RS24765 ENOG4105D56 permease protein FOC77_RS24770 ENOG4107FKK extracellular solute-binding protein family 1 FOC77_RS24775 ENOG4105C5Y PTS System FOC77_RS24780 ENOG4108W7F transporter, permease FOC77_RS24785 ENOG4108JJB ABC transporter FOC77_RS24790 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein FOC77_RS24795 ENOG4105ETU transcriptional activator (TenA FOC77_RS24805 ENOG41080UX Methyltransferase FOC77_RS24810 ENOG4108IV0 ABC, transporter FOC77_RS24815 ENOG4105C0Z ABC transporter FOC77_RS24820 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC77_RS24825 ENOG4105C32 Amino acid ABC transporter (Permease) FOC77_RS24830 ENOG4105CP9 extracellular ligand-binding receptor FOC77_RS24850 ENOG4108HQS Glycine betaine FOC77_RS24860 ENOG4105DSG hydrolase family 43 FOC77_RS24875 ENOG4105NTD Inherit from COG: Hydrolase FOC77_RS24885 ENOG4105F5H Glycosyl Hydrolase Family 88 FOC77_RS24905 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOC77_RS24910 ENOG41075H3 AraC family transcriptional regulator FOC77_RS24915 ENOG4107KJX Transcriptional regulator FOC77_RS24920 ENOG4105CTX dehydratase FOC77_RS24925 ENOG4105D2H Uronic isomerase FOC77_RS24935 ENOG4107TDE lipolytic protein G-D-S-L family FOC77_RS24945 ENOG4105BZ1 (ABC) transporter FOC77_RS24950 ENOG4107QNK )-transporter FOC77_RS24980 ENOG4105E1J oxidoreductase FOC77_RS24985 ENOG4105CH6 catalase FOC77_RS25015 ENOG4108MJI response regulator FOC77_RS25020 ENOG4105BZU Histidine kinase FOC77_RS25025 ENOG4105BZU Histidine kinase FOC77_RS25035 ENOG4108JQ7 (ABC) transporter FOC77_RS25045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC77_RS25050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC77_RS25070 ENOG4105E5K Alpha-amylase FOC77_RS25075 ENOG4107QM2 Aldo Keto reductase FOC77_RS25080 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FOC77_RS25085 ENOG4105KJM monovalent cation h antiporter subunit g FOC77_RS25095 ENOG4105SC1 monovalent cation H antiporter subunit E FOC77_RS25100 ENOG4108JPZ Monovalent cation H antiporter subunit D FOC77_RS25105 ENOG4105MKQ Monovalent cation H antiporter subunit C FOC77_RS25110 ENOG4105HC0 Na H antiporter FOC77_RS25115 ENOG4105D65 subunit l FOC77_RS25130 ENOG4105CUT histidyl-tRNA synthetase FOC77_RS25135 ENOG4106N3A copper homeostasis protein cutc FOC77_RS25145 ENOG4105ETE Transcriptional regulator (LacI family FOC77_RS25150 ENOG4107T40 Inherit from COG: Glycosyltransferase 36 FOC77_RS25155 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FOC77_RS25160 ENOG4105DRS transport system, permease FOC77_RS25165 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FOC77_RS25170 ENOG4107FKK extracellular solute-binding protein family 1 FOC77_RS25185 ENOG4106A2Z transcriptional regulator antitoxin, MazE FOC77_RS25205 ENOG4108IUW ABC transporter FOC77_RS25215 ENOG4107RZC phospholipase d FOC77_RS25220 ENOG4105D3R alkyl hydroperoxide reductase FOC77_RS25225 ENOG4108JU3 Alkyl hydroperoxide reductase FOC77_RS25250 ENOG4105CS2 ec 3.2.1.21 FOC77_RS25260 ENOG4105CK1 PTS System FOC77_RS25265 ENOG4105VZJ PTS System FOC77_RS25270 ENOG4105DSG hydrolase family 43