locus-tag	class	description
HLK66_RS00010	COG0592	DNA-directed DNA polymerase activity
HLK66_RS00015	COG2501	S4 domain
HLK66_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLK66_RS00030	COG0187	DNA topoisomerase II activity
HLK66_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLK66_RS00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HLK66_RS00075	COG0517	IMP dehydrogenase activity
HLK66_RS00075	COG0516	GMP reductase activity
HLK66_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HLK66_RS00105	COG1428	Deoxynucleoside kinase
HLK66_RS00110	COG1428	Deoxynucleoside kinase
HLK66_RS00115	COG0352	thiamine-phosphate diphosphorylase activity
HLK66_RS00125	COG2104	thiamine diphosphate biosynthetic process
HLK66_RS00130	COG2022	thiamine diphosphate biosynthetic process
HLK66_RS00135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLK66_RS00140	COG3858	chitin binding
HLK66_RS00140	COG1388	LysM domain
HLK66_RS00145	COG1335	isochorismatase
HLK66_RS00150	COG0590	tRNA wobble adenosine to inosine editing
HLK66_RS00160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLK66_RS00165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HLK66_RS00170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLK66_RS00215	COG1982	Orn Lys Arg decarboxylase major
HLK66_RS00225	COG3870	Protein conserved in bacteria
HLK66_RS00230	COG1728	Protein conserved in bacteria
HLK66_RS00235	COG0470	DNA polymerase III
HLK66_RS00240	COG1774	PSP1 C-terminal conserved region
HLK66_RS00245	COG4467	Involved in initiation control of chromosome replication
HLK66_RS00250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HLK66_RS00255	COG2827	Endonuclease containing a URI domain
HLK66_RS00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HLK66_RS00265	COG2002	toxin-antitoxin pair type II binding
HLK66_RS00275	COG0084	hydrolase, TatD family'
HLK66_RS00280	COG3584	3D domain protein
HLK66_RS00280	COG3583	domain protein
HLK66_RS00290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLK66_RS00300	COG4466	Protein conserved in bacteria
HLK66_RS00310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HLK66_RS00315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLK66_RS00320	COG0251	oxidation-reduction process
HLK66_RS00325	COG2088	sporulation resulting in formation of a cellular spore
HLK66_RS00330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLK66_RS00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLK66_RS00340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HLK66_RS00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLK66_RS00360	COG2002	toxin-antitoxin pair type II binding
HLK66_RS00365	COG2188	Transcriptional regulator
HLK66_RS00375	COG2244	polysaccharide biosynthetic process
HLK66_RS00380	COG3956	TIGRFAM MazG family protein
HLK66_RS00385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLK66_RS00400	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HLK66_RS00405	COG1098	S1 RNA binding domain
HLK66_RS00415	COG2208	phosphoserine phosphatase activity
HLK66_RS00420	COG2304	oxidoreductase activity
HLK66_RS00425	COG0515	serine threonine protein kinase
HLK66_RS00430	COG0037	tRNA processing
HLK66_RS00445	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HLK66_RS00450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HLK66_RS00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLK66_RS00460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLK66_RS00465	COG0512	Glutamine amidotransferase of anthranilate synthase
HLK66_RS00470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLK66_RS00475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLK66_RS00480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HLK66_RS00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLK66_RS00490	COG1396	sequence-specific DNA binding
HLK66_RS00495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLK66_RS00500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HLK66_RS00585	COG3880	PFAM UvrB UvrC protein
HLK66_RS00590	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HLK66_RS00595	COG0542	response to heat
HLK66_RS00600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLK66_RS00605	COG4956	integral membrane protein (PIN domain superfamily)
HLK66_RS00610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HLK66_RS00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HLK66_RS00620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLK66_RS00625	COG1045	serine acetyltransferase
HLK66_RS00630	COG0215	cysteine-tRNA ligase activity
HLK66_RS00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLK66_RS00645	COG3688	RNA-binding protein containing a PIN domain
HLK66_RS00655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLK66_RS00660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLK66_RS00665	COG0250	Participates in transcription elongation, termination and antitermination
HLK66_RS00670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLK66_RS00675	COG0081	regulation of translation
HLK66_RS00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HLK66_RS00685	COG0222	ribosome binding
HLK66_RS00690	COG2813	Specifically methylates the guanine in position
HLK66_RS00700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLK66_RS00705	COG1358	cellular component organization or biogenesis
HLK66_RS00710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLK66_RS00715	COG0049	tRNA binding
HLK66_RS00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLK66_RS00730	COG0051	transcription antitermination factor activity, RNA binding
HLK66_RS00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HLK66_RS00740	COG0088	Forms part of the polypeptide exit tunnel
HLK66_RS00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLK66_RS00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HLK66_RS00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HLK66_RS00775	COG0255	Belongs to the universal ribosomal protein uL29 family
HLK66_RS00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HLK66_RS00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HLK66_RS00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HLK66_RS00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HLK66_RS00825	COG1841	ribosomal large subunit assembly
HLK66_RS00835	COG0201	protein transport
HLK66_RS00840	COG0563	adenylate kinase activity
HLK66_RS00845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HLK66_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLK66_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HLK66_RS00865	COG0202	RNA polymerase activity
HLK66_RS00870	COG0203	ribosomal protein L17
HLK66_RS00875	COG1122	ATPase activity
HLK66_RS00880	COG1122	ATPase activity
HLK66_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HLK66_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HLK66_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLK66_RS00955	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS00960	COG1263	PTS System
HLK66_RS00960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS00960	COG2190	(PTS) system
HLK66_RS00970	COG2190	(PTS) system
HLK66_RS01010	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK66_RS01015	COG0489	protein tyrosine kinase activity
HLK66_RS01025	COG0726	polysaccharide deacetylase
HLK66_RS01100	COG1595	DNA-templated transcription, initiation
HLK66_RS01105	COG5662	AntiSigma factor
HLK66_RS01110	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HLK66_RS01115	COG4856	YbbR-like protein
HLK66_RS01120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLK66_RS01125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLK66_RS01150	COG1846	Transcriptional regulator
HLK66_RS01165	COG0778	Nitroreductase
HLK66_RS01180	COG0745	RESPONSE REGULATOR receiver
HLK66_RS01185	COG2205	protein histidine kinase activity
HLK66_RS01210	COG0745	RESPONSE REGULATOR receiver
HLK66_RS01215	COG0642	Histidine kinase
HLK66_RS01235	COG1733	regulation of RNA biosynthetic process
HLK66_RS01245	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_RS01255	COG1063	alcohol dehydrogenase
HLK66_RS01260	COG3730	PTS system glucitol sorbitol-specific
HLK66_RS01265	COG3732	PTS system glucitol sorbitol-specific
HLK66_RS01280	COG0656	L-ascorbic acid biosynthetic process
HLK66_RS01290	COG2188	Transcriptional regulator
HLK66_RS01295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS01295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS01300	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS01300	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS01310	COG3716	PTS system mannose fructose sorbose family IID component
HLK66_RS01315	COG2807	transmembrane transport
HLK66_RS01320	COG3344	reverse transcriptase
HLK66_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS01340	COG2807	transmembrane transport
HLK66_RS01350	COG4607	ABC-type enterochelin transport system periplasmic component
HLK66_RS01355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_RS01360	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_RS01365	COG1120	ATPase activity
HLK66_RS01370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLK66_RS01380	COG0730	response to heat
HLK66_RS01395	COG2210	Belongs to the sulfur carrier protein TusA family
HLK66_RS01405	COG1114	Component of the transport system for branched-chain amino acids
HLK66_RS01410	COG2378	regulation of single-species biofilm formation
HLK66_RS01420	COG0519	Catalyzes the synthesis of GMP from XMP
HLK66_RS01425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLK66_RS01435	COG1595	DNA-templated transcription, initiation
HLK66_RS01440	COG0492	ferredoxin-NADP+ reductase activity
HLK66_RS01445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLK66_RS01455	COG0456	acetyltransferase
HLK66_RS01480	COG1595	DNA-templated transcription, initiation
HLK66_RS01490	COG1316	TRANSCRIPTIONal
HLK66_RS01500	COG0454	-acetyltransferase
HLK66_RS01525	COG1011	Hydrolase
HLK66_RS01535	COG1609	Transcriptional regulator
HLK66_RS01540	COG2182	Extracellular solute-binding protein
HLK66_RS01545	COG1175	transmembrane transport
HLK66_RS01550	COG3833	ABC-type maltose transport systems, permease component
HLK66_RS01555	COG1874	Beta-galactosidase
HLK66_RS01570	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLK66_RS01575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HLK66_RS01580	COG0583	DNA-binding transcription factor activity
HLK66_RS01595	COG0175	sulfate reduction
HLK66_RS01600	COG0306	phosphate transporter
HLK66_RS01605	COG2046	Belongs to the sulfate adenylyltransferase family
HLK66_RS01610	COG0529	Catalyzes the synthesis of activated sulfate
HLK66_RS01635	COG2205	protein histidine kinase activity
HLK66_RS01635	COG0784	Response regulator, receiver
HLK66_RS01640	COG5002	protein histidine kinase activity
HLK66_RS01655	COG0604	alcohol dehydrogenase
HLK66_RS01660	COG2404	hydrolase activity, acting on ester bonds
HLK66_RS01675	COG1657	PFAM Prenyltransferase squalene oxidase
HLK66_RS01680	COG0017	Asparaginyl-tRNA synthetase
HLK66_RS01685	COG3386	PFAM SMP-30 Gluconolaconase
HLK66_RS01690	COG0659	secondary active sulfate transmembrane transporter activity
HLK66_RS01700	COG3620	sequence-specific DNA binding
HLK66_RS01710	COG1263	PTS System
HLK66_RS01710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS01710	COG2190	(PTS) system
HLK66_RS01735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_RS01750	COG3328	transposase activity
HLK66_RS01760	COG4149	molybdate abc transporter
HLK66_RS01765	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLK66_RS01770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK66_RS01805	COG1252	NADH dehydrogenase
HLK66_RS01820	COG1122	ATPase activity
HLK66_RS01840	COG2244	polysaccharide biosynthetic process
HLK66_RS01845	COG0438	transferase activity, transferring glycosyl groups
HLK66_RS01845	COG0297	glycogen (starch) synthase activity
HLK66_RS01850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK66_RS01855	COG3307	-O-antigen
HLK66_RS01860	COG3206	protein involved in exopolysaccharide biosynthesis
HLK66_RS01865	COG1215	transferase activity, transferring glycosyl groups
HLK66_RS01870	COG0438	transferase activity, transferring glycosyl groups
HLK66_RS01875	COG1959	2 iron, 2 sulfur cluster binding
HLK66_RS01895	COG2362	D-Aminopeptidase
HLK66_RS01900	COG0601	transmembrane transport
HLK66_RS01905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK66_RS01910	COG0444	Belongs to the ABC transporter superfamily
HLK66_RS01915	COG4166	transmembrane transport
HLK66_RS01920	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLK66_RS01925	COG4948	Mandelate Racemase Muconate Lactonizing
HLK66_RS01930	COG0791	NLP P60 protein
HLK66_RS01935	COG4608	Belongs to the ABC transporter superfamily
HLK66_RS01945	COG1120	ATPase activity
HLK66_RS01960	COG0667	Aldo Keto reductase
HLK66_RS01965	COG0129	dihydroxy-acid dehydratase activity
HLK66_RS01970	COG0628	permease
HLK66_RS01975	COG0789	Transcriptional regulator
HLK66_RS01980	COG1253	flavin adenine dinucleotide binding
HLK66_RS01990	COG3711	transcriptional antiterminator
HLK66_RS01995	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS02000	COG0246	Mannitol dehydrogenase
HLK66_RS02005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLK66_RS02015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLK66_RS02030	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_RS02035	COG4605	iron ion homeostasis
HLK66_RS02040	COG4604	ABC transporter, ATP-binding protein
HLK66_RS02045	COG4607	ABC-type enterochelin transport system periplasmic component
HLK66_RS02050	COG0673	inositol 2-dehydrogenase activity
HLK66_RS02055	COG1940	carbohydrate kinase activity
HLK66_RS02060	COG5002	protein histidine kinase activity
HLK66_RS02060	COG3850	Histidine kinase
HLK66_RS02065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLK66_RS02070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLK66_RS02100	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK66_RS02105	COG1177	transmembrane transport
HLK66_RS02110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HLK66_RS02115	COG2861	carbohydrate metabolic process
HLK66_RS02120	COG0668	transmembrane transport
HLK66_RS02125	COG0569	domain protein
HLK66_RS02130	COG0783	Belongs to the Dps family
HLK66_RS02135	COG0772	Belongs to the SEDS family
HLK66_RS02140	COG2239	Acts as a magnesium transporter
HLK66_RS02145	COG0402	S-adenosylhomocysteine deaminase activity
HLK66_RS02155	COG1489	DNA binding
HLK66_RS02160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLK66_RS02170	COG1120	ATPase activity
HLK66_RS02175	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HLK66_RS02190	COG1492	cobalamin metabolic process
HLK66_RS02195	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HLK66_RS02200	COG0588	phosphoglycerate mutase activity
HLK66_RS02205	COG2096	Adenosyltransferase
HLK66_RS02225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLK66_RS02235	COG0513	Belongs to the DEAD box helicase family
HLK66_RS02240	COG3402	PFAM membrane-flanked domain
HLK66_RS02245	COG3428	Bacterial PH domain
HLK66_RS02250	COG0705	Rhomboid family
HLK66_RS02255	COG0736	holo-[acyl-carrier-protein] synthase activity
HLK66_RS02260	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HLK66_RS02270	COG0864	Transcriptional regulator
HLK66_RS02275	COG2337	Toxic component of a toxin-antitoxin (TA) module
HLK66_RS02280	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_RS02285	COG2172	sigma factor antagonist activity
HLK66_RS02290	COG2208	phosphoserine phosphatase activity
HLK66_RS02295	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_RS02300	COG2172	sigma factor antagonist activity
HLK66_RS02305	COG1191	sigma factor activity
HLK66_RS02310	COG2208	phosphoserine phosphatase activity
HLK66_RS02315	COG2183	response to ionizing radiation
HLK66_RS02325	COG3091	SprT-like family
HLK66_RS02405	COG0802	atpase or kinase
HLK66_RS02410	COG1214	PFAM Peptidase M22, glycoprotease
HLK66_RS02415	COG0456	acetyltransferase
HLK66_RS02425	COG0488	(ABC) transporter
HLK66_RS02430	COG0315	cyclic pyranopterin monophosphate synthase activity
HLK66_RS02435	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HLK66_RS02445	COG1266	CAAX protease self-immunity
HLK66_RS02450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HLK66_RS02455	COG0459	protein refolding
HLK66_RS02460	COG0346	lactoylglutathione lyase activity
HLK66_RS02490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_RS02495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS02495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_RS02495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_RS02505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLK66_RS02510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLK66_RS02525	COG3715	PTS system
HLK66_RS02530	COG3716	PTS system mannose fructose sorbose family IID component
HLK66_RS02535	COG0673	inositol 2-dehydrogenase activity
HLK66_RS02540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLK66_RS02545	COG0277	FAD linked oxidase domain protein
HLK66_RS02560	COG0840	transmembrane signaling receptor activity
HLK66_RS02565	COG0733	neurotransmitter:sodium symporter activity
HLK66_RS02580	COG4565	transcriptional regulatory protein
HLK66_RS02600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HLK66_RS02605	COG1840	ABC-type Fe3 transport system, periplasmic component
HLK66_RS02615	COG3842	ATPase activity
HLK66_RS02625	COG1533	DNA photolyase activity
HLK66_RS02635	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLK66_RS02640	COG3871	stress protein (general stress protein 26)
HLK66_RS02645	COG4294	response to UV
HLK66_RS02650	COG4294	response to UV
HLK66_RS02660	COG2211	Major facilitator Superfamily
HLK66_RS02670	COG0583	DNA-binding transcription factor activity
HLK66_RS02675	COG1473	amidohydrolase
HLK66_RS02680	COG1288	antiporter activity
HLK66_RS02690	COG0702	epimerase
HLK66_RS02695	COG2188	Transcriptional regulator
HLK66_RS02700	COG2222	sugar isomerase
HLK66_RS02705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_RS02710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HLK66_RS02740	COG1312	Catalyzes the dehydration of D-mannonate
HLK66_RS02750	COG1904	glucuronate isomerase
HLK66_RS02760	COG2190	(PTS) system
HLK66_RS02760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS02760	COG1263	PTS System
HLK66_RS02765	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS02770	COG3711	transcriptional antiterminator
HLK66_RS02780	COG2310	stress, protein
HLK66_RS02785	COG0714	Associated with various cellular activities
HLK66_RS02790	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HLK66_RS02795	COG1305	Transglutaminase-like
HLK66_RS02800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLK66_RS02800	COG0519	Catalyzes the synthesis of GMP from XMP
HLK66_RS02805	COG0730	response to heat
HLK66_RS02810	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HLK66_RS02815	COG0517	IMP dehydrogenase activity
HLK66_RS02820	COG0574	Belongs to the PEP-utilizing enzyme family
HLK66_RS02820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLK66_RS02825	COG2252	PERMEase
HLK66_RS02830	COG3711	transcriptional antiterminator
HLK66_RS02835	COG1263	PTS System
HLK66_RS02835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS02835	COG2190	(PTS) system
HLK66_RS02855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLK66_RS02900	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HLK66_RS02910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLK66_RS02915	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLK66_RS02920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLK66_RS02925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLK66_RS02930	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLK66_RS02935	COG0047	phosphoribosylformylglycinamidine synthase activity
HLK66_RS02945	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLK66_RS02950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HLK66_RS02955	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLK66_RS02960	COG0138	bifunctional purine biosynthesis protein purh
HLK66_RS02965	COG0151	Belongs to the GarS family
HLK66_RS02970	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS02985	COG1470	cell adhesion involved in biofilm formation
HLK66_RS02990	COG4496	protein, YerC YecD
HLK66_RS02995	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HLK66_RS03000	COG0210	DNA helicase
HLK66_RS03005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLK66_RS03010	COG4851	CamS sex pheromone cAM373 precursor
HLK66_RS03015	COG5506	Protein of unknown function (DUF1694)
HLK66_RS03020	COG1764	response to oxidative stress
HLK66_RS03025	COG1846	Transcriptional regulator
HLK66_RS03035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLK66_RS03045	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLK66_RS03065	COG1595	DNA-templated transcription, initiation
HLK66_RS03085	COG1597	lipid kinase activity
HLK66_RS03110	COG3173	Aminoglycoside phosphotransferase
HLK66_RS03140	COG2226	methyltransferase
HLK66_RS03155	COG0500	methyltransferase
HLK66_RS03170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLK66_RS03175	COG0210	DNA helicase
HLK66_RS03195	COG2814	Major facilitator Superfamily
HLK66_RS03200	COG0604	alcohol dehydrogenase
HLK66_RS03210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLK66_RS03215	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HLK66_RS03220	COG2205	protein histidine kinase activity
HLK66_RS03230	COG0456	acetyltransferase
HLK66_RS03235	COG1388	LysM domain
HLK66_RS03235	COG3584	3D domain protein
HLK66_RS03255	COG2972	Histidine kinase
HLK66_RS03280	COG0166	Belongs to the GPI family
HLK66_RS03285	COG1733	regulation of RNA biosynthetic process
HLK66_RS03290	COG2514	catechol 2,3-dioxygenase activity
HLK66_RS03295	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_RS03305	COG1785	Belongs to the alkaline phosphatase family
HLK66_RS03310	COG1794	racemase activity, acting on amino acids and derivatives
HLK66_RS03315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS03320	COG3480	Lon protease (S16) C-terminal proteolytic domain
HLK66_RS03330	COG3279	Response regulator of the LytR AlgR family
HLK66_RS03350	COG1695	Transcriptional regulator
HLK66_RS03390	COG1132	(ABC) transporter
HLK66_RS03405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLK66_RS03415	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLK66_RS03425	COG2814	Major facilitator Superfamily
HLK66_RS03430	COG0527	aspartate kinase activity
HLK66_RS03440	COG0765	amino acid transport
HLK66_RS03445	COG1126	abc transporter atp-binding protein
HLK66_RS03455	COG1473	amidohydrolase
HLK66_RS03460	COG1473	amidohydrolase
HLK66_RS03465	COG0444	Belongs to the ABC transporter superfamily
HLK66_RS03470	COG4608	Belongs to the ABC transporter superfamily
HLK66_RS03475	COG0601	transmembrane transport
HLK66_RS03480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK66_RS03490	COG1132	(ABC) transporter
HLK66_RS03495	COG1132	(ABC) transporter
HLK66_RS03500	COG2357	RelA SpoT domain protein
HLK66_RS03505	COG0513	Belongs to the DEAD box helicase family
HLK66_RS03520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLK66_RS03525	COG0697	spore germination
HLK66_RS03560	COG2197	response regulator
HLK66_RS03565	COG2244	polysaccharide biosynthetic process
HLK66_RS03580	COG0598	Magnesium transport protein CorA
HLK66_RS03585	COG1607	acyl-coa hydrolase
HLK66_RS03595	COG0670	Belongs to the BI1 family
HLK66_RS03600	COG1970	mechanosensitive ion channel activity
HLK66_RS03605	COG1254	Belongs to the acylphosphatase family
HLK66_RS03615	COG2309	aminopeptidase activity
HLK66_RS03620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLK66_RS03625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLK66_RS03625	COG0551	DNA topoisomerase type I activity
HLK66_RS03640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HLK66_RS03645	COG1360	Flagellar Motor Protein
HLK66_RS03655	COG1522	sequence-specific DNA binding
HLK66_RS03655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_RS03660	COG2313	pseudouridylate synthase activity
HLK66_RS03665	COG1396	sequence-specific DNA binding
HLK66_RS03680	COG1396	sequence-specific DNA binding
HLK66_RS03685	COG2188	Transcriptional regulator
HLK66_RS03695	COG0024	Methionine aminopeptidase
HLK66_RS03700	COG4840	Belongs to the UPF0435 family
HLK66_RS03705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLK66_RS03715	COG1295	ribonuclease BN
HLK66_RS03720	COG2217	Heavy metal translocating P-type atpase
HLK66_RS03725	COG0477	Major facilitator Superfamily
HLK66_RS03730	COG0387	Pfam Sodium calcium exchanger
HLK66_RS03735	COG2364	Membrane
HLK66_RS03745	COG0535	radical SAM domain protein
HLK66_RS03760	COG1309	transcriptional regulator
HLK66_RS03780	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HLK66_RS03785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_RS03795	COG1959	2 iron, 2 sulfur cluster binding
HLK66_RS03815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLK66_RS03820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLK66_RS03880	COG0210	DNA helicase
HLK66_RS03905	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLK66_RS03940	COG4842	Belongs to the WXG100 family
HLK66_RS03945	COG5417	Belongs to the EsaB family
HLK66_RS03950	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLK66_RS03955	COG1674	ftsk spoiiie
HLK66_RS03955	COG0433	COG0433 Predicted ATPase
HLK66_RS03960	COG1511	domain protein
HLK66_RS03970	COG0488	(ABC) transporter
HLK66_RS03975	COG3940	Belongs to the glycosyl hydrolase 43 family
HLK66_RS03985	COG0737	Belongs to the 5'-nucleotidase family
HLK66_RS03990	COG0366	Alpha amylase catalytic
HLK66_RS03990	COG1874	Beta-galactosidase
HLK66_RS04005	COG0784	Response regulator, receiver
HLK66_RS04005	COG2205	protein histidine kinase activity
HLK66_RS04030	COG4191	Histidine kinase
HLK66_RS04050	COG4807	Protein conserved in bacteria
HLK66_RS04060	COG0583	DNA-binding transcription factor activity
HLK66_RS04085	COG1125	glycine betaine transport
HLK66_RS04085	COG0517	IMP dehydrogenase activity
HLK66_RS04090	COG1174	glycine betaine transport
HLK66_RS04110	COG0573	inorganic phosphate transmembrane transporter activity
HLK66_RS04115	COG0581	inorganic phosphate transmembrane transporter activity
HLK66_RS04120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLK66_RS04140	COG2207	Transcriptional regulator
HLK66_RS04140	COG4753	response regulator
HLK66_RS04145	COG4213	ABC transporter substrate-binding protein
HLK66_RS04150	COG1129	ABC transporter
HLK66_RS04155	COG4214	carbohydrate transport
HLK66_RS04160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLK66_RS04165	COG2211	Major facilitator Superfamily
HLK66_RS04185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLK66_RS04195	COG0702	epimerase
HLK66_RS04200	COG1733	regulation of RNA biosynthetic process
HLK66_RS04210	COG0765	amino acid transport
HLK66_RS04225	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLK66_RS04230	COG0322	excinuclease ABC activity
HLK66_RS04250	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HLK66_RS04255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLK66_RS04260	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HLK66_RS04265	COG4260	virion core protein, lumpy skin disease virus
HLK66_RS04300	COG3534	alpha-L-arabinofuranosidase
HLK66_RS04305	COG1780	Probably involved in ribonucleotide reductase function
HLK66_RS04310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLK66_RS04315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLK66_RS04320	COG1595	DNA-templated transcription, initiation
HLK66_RS04335	COG1132	(ABC) transporter
HLK66_RS04340	COG1132	(ABC) transporter
HLK66_RS04365	COG0840	transmembrane signaling receptor activity
HLK66_RS04390	COG3275	phosphorelay sensor kinase activity
HLK66_RS04395	COG3279	Response regulator of the LytR AlgR family
HLK66_RS04400	COG2223	nitrite transmembrane transporter activity
HLK66_RS04405	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HLK66_RS04410	COG3853	Toxic anion resistance protein (TelA)
HLK66_RS04415	COG0384	phenazine biosynthesis protein PhzF
HLK66_RS04420	COG4708	membrane
HLK66_RS04430	COG1136	(ABC) transporter
HLK66_RS04435	COG0577	efflux transmembrane transporter activity
HLK66_RS04435	COG1136	(ABC) transporter
HLK66_RS04445	COG5002	protein histidine kinase activity
HLK66_RS04445	COG3850	Histidine kinase
HLK66_RS04450	COG1607	acyl-coa hydrolase
HLK66_RS04460	COG0683	leucine binding
HLK66_RS04485	COG2706	6-phosphogluconolactonase activity
HLK66_RS04490	COG3507	Belongs to the glycosyl hydrolase 43 family
HLK66_RS04500	COG2137	regulation of response to DNA damage stimulus
HLK66_RS04520	COG1988	membrane-bound metal-dependent
HLK66_RS04525	COG1194	a g-specific adenine glycosylase
HLK66_RS04535	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS04555	COG1132	(ABC) transporter
HLK66_RS04560	COG4129	membrane
HLK66_RS04565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HLK66_RS04575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLK66_RS04580	COG0735	belongs to the Fur family
HLK66_RS04785	COG0398	Pfam SNARE associated Golgi protein
HLK66_RS04790	COG0745	RESPONSE REGULATOR receiver
HLK66_RS04795	COG5002	protein histidine kinase activity
HLK66_RS04795	COG0642	Histidine kinase
HLK66_RS04810	COG1132	(ABC) transporter
HLK66_RS04820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS04830	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_RS04845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_RS04850	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS04855	COG3711	transcriptional antiterminator
HLK66_RS04855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS04910	COG1304	FMN binding
HLK66_RS04920	COG1846	Transcriptional regulator
HLK66_RS04935	COG0477	Major facilitator Superfamily
HLK66_RS04940	COG3443	Belongs to the bacterial solute-binding protein 9 family
HLK66_RS04945	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLK66_RS04945	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLK66_RS04965	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HLK66_RS04965	COG0456	acetyltransferase
HLK66_RS04970	COG0789	Transcriptional regulator
HLK66_RS04975	COG0697	spore germination
HLK66_RS04985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLK66_RS04990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_RS04995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_RS05005	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HLK66_RS05015	COG0745	RESPONSE REGULATOR receiver
HLK66_RS05020	COG2205	protein histidine kinase activity
HLK66_RS05025	COG1136	(ABC) transporter
HLK66_RS05035	COG1902	pentaerythritol trinitrate reductase activity
HLK66_RS05040	COG3711	transcriptional antiterminator
HLK66_RS05045	COG1263	PTS System
HLK66_RS05045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS05045	COG2190	(PTS) system
HLK66_RS05050	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS05055	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HLK66_RS05060	COG1984	allophanate hydrolase subunit 2
HLK66_RS05065	COG2814	Major facilitator Superfamily
HLK66_RS05085	COG1349	DNA-binding transcription factor activity
HLK66_RS05090	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HLK66_RS05100	COG1132	(ABC) transporter
HLK66_RS05105	COG0641	radical SAM
HLK66_RS05115	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS05145	COG2205	protein histidine kinase activity
HLK66_RS05150	COG2205	protein histidine kinase activity
HLK66_RS05170	COG1846	Transcriptional regulator
HLK66_RS05175	COG0346	lactoylglutathione lyase activity
HLK66_RS05180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLK66_RS05185	COG0346	lactoylglutathione lyase activity
HLK66_RS05190	COG0400	carboxylic ester hydrolase activity
HLK66_RS05205	COG2391	methyltransferase activity
HLK66_RS05220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLK66_RS05225	COG0431	NADPH-dependent FMN reductase
HLK66_RS05240	COG2972	Histidine kinase
HLK66_RS05245	COG2207	Transcriptional regulator
HLK66_RS05245	COG4753	response regulator
HLK66_RS05250	COG3344	reverse transcriptase
HLK66_RS05255	COG2814	Major facilitator Superfamily
HLK66_RS05255	COG0477	Major facilitator Superfamily
HLK66_RS05260	COG3328	transposase activity
HLK66_RS05270	COG0741	lytic transglycosylase activity
HLK66_RS05275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLK66_RS05290	COG4221	oxidoreductase activity
HLK66_RS05295	COG0789	Transcriptional regulator
HLK66_RS05325	COG0586	Pfam SNARE associated Golgi protein
HLK66_RS05340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLK66_RS05355	COG1063	alcohol dehydrogenase
HLK66_RS05370	COG2116	formate transmembrane transporter activity
HLK66_RS05385	COG3382	B3 4 domain protein
HLK66_RS05390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HLK66_RS05405	COG0778	Nitroreductase
HLK66_RS05410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLK66_RS05415	COG2766	serine protein kinase
HLK66_RS05450	COG2832	Protein of unknown function (DUF454)
HLK66_RS05465	COG0667	Aldo Keto reductase
HLK66_RS05475	COG1737	Transcriptional regulator
HLK66_RS05480	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS05485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS05485	COG2190	(PTS) system
HLK66_RS05485	COG1263	PTS System
HLK66_RS05490	COG0641	radical SAM
HLK66_RS05510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HLK66_RS05520	COG1917	Cupin 2, conserved barrel domain protein
HLK66_RS05520	COG4977	sequence-specific DNA binding
HLK66_RS05525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS05525	COG1263	PTS System
HLK66_RS05580	COG0346	lactoylglutathione lyase activity
HLK66_RS05585	COG1733	regulation of RNA biosynthetic process
HLK66_RS05590	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS05610	COG2329	Antibiotic biosynthesis monooxygenase
HLK66_RS05615	COG2207	Transcriptional regulator
HLK66_RS05615	COG1917	Cupin 2, conserved barrel domain protein
HLK66_RS05620	COG0697	spore germination
HLK66_RS05625	COG2315	Protein conserved in bacteria
HLK66_RS05630	COG2207	Transcriptional regulator
HLK66_RS05635	COG2211	Major facilitator Superfamily
HLK66_RS05640	COG3250	beta-galactosidase activity
HLK66_RS05650	COG1312	Catalyzes the dehydration of D-mannonate
HLK66_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS05660	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HLK66_RS05670	COG2197	response regulator
HLK66_RS05675	COG4585	Histidine kinase
HLK66_RS05680	COG3239	Fatty acid desaturase
HLK66_RS05685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLK66_RS05695	COG1396	sequence-specific DNA binding
HLK66_RS05710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLK66_RS05735	COG0745	RESPONSE REGULATOR receiver
HLK66_RS05740	COG5002	protein histidine kinase activity
HLK66_RS05745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_RS05750	COG0306	phosphate transporter
HLK66_RS05755	COG1392	Phosphate transport regulator
HLK66_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS05770	COG0656	L-ascorbic acid biosynthetic process
HLK66_RS05775	COG2261	transglycosylase associated protein
HLK66_RS05780	COG0564	pseudouridine synthase activity
HLK66_RS05790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_RS05800	COG3153	acetyltransferase
HLK66_RS05800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLK66_RS05825	COG2252	PERMEase
HLK66_RS05840	COG0583	DNA-binding transcription factor activity
HLK66_RS05845	COG1309	transcriptional regulator
HLK66_RS05850	COG2076	Multidrug Resistance protein
HLK66_RS05875	COG2378	regulation of single-species biofilm formation
HLK66_RS05935	COG1694	Mazg nucleotide pyrophosphohydrolase
HLK66_RS05945	COG4978	Transcriptional regulator
HLK66_RS05945	COG0789	Transcriptional regulator
HLK66_RS05950	COG1811	Na channel or pump
HLK66_RS05955	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HLK66_RS05960	COG1131	(ABC) transporter
HLK66_RS05970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_RS05975	COG0598	Magnesium transport protein CorA
HLK66_RS05980	COG0745	RESPONSE REGULATOR receiver
HLK66_RS05985	COG1253	flavin adenine dinucleotide binding
HLK66_RS05990	COG1253	flavin adenine dinucleotide binding
HLK66_RS05995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_RS06000	COG0840	transmembrane signaling receptor activity
HLK66_RS06000	COG5278	phosphoserine phosphatase activity
HLK66_RS06015	COG2814	Major facilitator Superfamily
HLK66_RS06025	COG1132	(ABC) transporter
HLK66_RS06030	COG1132	(ABC) transporter
HLK66_RS06035	COG2819	hydrolase of the alpha beta superfamily
HLK66_RS06040	COG2207	Transcriptional regulator
HLK66_RS06040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLK66_RS06045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLK66_RS06050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_RS06065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_RS06070	COG2819	hydrolase of the alpha beta superfamily
HLK66_RS06085	COG3842	ATPase activity
HLK66_RS06090	COG2508	Transcriptional regulator
HLK66_RS06115	COG0189	ligase activity
HLK66_RS06120	COG0189	ligase activity
HLK66_RS06125	COG0189	ligase activity
HLK66_RS06145	COG0561	phosphatase activity
HLK66_RS06150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLK66_RS06155	COG2252	PERMEase
HLK66_RS06160	COG4152	abc transporter atp-binding protein
HLK66_RS06165	COG1668	transmembrane transport
HLK66_RS06170	COG0420	3'-5' exonuclease activity
HLK66_RS06175	COG4717	serine-type aminopeptidase activity
HLK66_RS06210	COG1846	Transcriptional regulator
HLK66_RS06220	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HLK66_RS06225	COG0537	adenosine 5'-monophosphoramidase activity
HLK66_RS06230	COG1131	(ABC) transporter
HLK66_RS06235	COG4473	ABC transporter
HLK66_RS06245	COG1473	amidohydrolase
HLK66_RS06255	COG3069	C4-dicarboxylate transmembrane transporter activity
HLK66_RS06265	COG4585	Histidine kinase
HLK66_RS06270	COG2197	response regulator
HLK66_RS06280	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HLK66_RS06290	COG1309	transcriptional regulator
HLK66_RS06295	COG1511	domain protein
HLK66_RS06300	COG0095	Lipoate-protein ligase
HLK66_RS06305	COG0501	Belongs to the peptidase M48B family
HLK66_RS06335	COG0823	Involved in the tonB-independent uptake of proteins
HLK66_RS06335	COG4946	Tricorn protease homolog
HLK66_RS06335	COG1506	peptidase
HLK66_RS06345	COG0398	Pfam SNARE associated Golgi protein
HLK66_RS06400	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLK66_RS06410	COG4585	Histidine kinase
HLK66_RS06415	COG2197	response regulator
HLK66_RS06420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_RS06425	COG1253	flavin adenine dinucleotide binding
HLK66_RS06430	COG1131	(ABC) transporter
HLK66_RS06445	COG2226	methyltransferase
HLK66_RS06450	COG1131	(ABC) transporter
HLK66_RS06460	COG1737	Transcriptional regulator
HLK66_RS06465	COG0673	inositol 2-dehydrogenase activity
HLK66_RS06470	COG0673	inositol 2-dehydrogenase activity
HLK66_RS06480	COG2207	Transcriptional regulator
HLK66_RS06480	COG0662	Cupin 2, conserved barrel domain protein
HLK66_RS06495	COG1247	-acetyltransferase
HLK66_RS06505	COG0367	asparagine synthase
HLK66_RS06510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLK66_RS06515	COG0697	spore germination
HLK66_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS06530	COG1666	GTP binding
HLK66_RS06540	COG2996	Protein conserved in bacteria
HLK66_RS06550	COG1307	EDD domain protein, DegV family
HLK66_RS06555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_RS06575	COG0561	phosphatase activity
HLK66_RS06580	COG1073	alpha beta
HLK66_RS06585	COG2151	metal-sulfur cluster biosynthetic enzyme
HLK66_RS06590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLK66_RS06595	COG0303	'Molybdopterin
HLK66_RS06600	COG1620	l-lactate permease
HLK66_RS06605	COG2186	Transcriptional regulator
HLK66_RS06610	COG0247	lactate metabolic process
HLK66_RS06615	COG1139	Iron-sulfur cluster binding protein
HLK66_RS06620	COG1556	Lactate utilization protein
HLK66_RS06625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLK66_RS06630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HLK66_RS06635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLK66_RS06655	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HLK66_RS06675	COG2267	carboxylic ester hydrolase activity
HLK66_RS06685	COG1744	ABC transporter substrate-binding protein PnrA-like
HLK66_RS06695	COG3711	transcriptional antiterminator
HLK66_RS06705	COG3730	PTS system glucitol sorbitol-specific
HLK66_RS06710	COG3732	PTS system glucitol sorbitol-specific
HLK66_RS06725	COG0561	phosphatase activity
HLK66_RS06735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLK66_RS06740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLK66_RS06745	COG0735	belongs to the Fur family
HLK66_RS06750	COG5504	Zn-dependent protease
HLK66_RS06760	COG0180	Tryptophanyl-tRNA synthetase
HLK66_RS06765	COG4166	transmembrane transport
HLK66_RS06770	COG0601	transmembrane transport
HLK66_RS06775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK66_RS06780	COG0444	Belongs to the ABC transporter superfamily
HLK66_RS06785	COG4608	Belongs to the ABC transporter superfamily
HLK66_RS06795	COG0456	acetyltransferase
HLK66_RS06800	COG1393	Belongs to the ArsC family
HLK66_RS06805	COG4862	establishment of competence for transformation
HLK66_RS06810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK66_RS06820	COG1164	Oligoendopeptidase f
HLK66_RS06830	COG2346	COG2346, Truncated hemoglobins
HLK66_RS06835	COG0741	lytic transglycosylase activity
HLK66_RS06840	COG4116	CYTH
HLK66_RS06850	COG2357	RelA SpoT domain protein
HLK66_RS06860	COG0564	pseudouridine synthase activity
HLK66_RS06865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLK66_RS06870	COG2239	Acts as a magnesium transporter
HLK66_RS06875	COG0475	glutathione-regulated potassium exporter activity
HLK66_RS06875	COG0569	domain protein
HLK66_RS06880	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HLK66_RS06910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLK66_RS06930	COG0210	DNA helicase
HLK66_RS06940	COG2323	membrane
HLK66_RS06945	COG2153	protein acetylation
HLK66_RS06950	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HLK66_RS06955	COG2382	esterase
HLK66_RS06960	COG1328	CTP reductase activity
HLK66_RS06965	COG0602	queuosine metabolic process
HLK66_RS06975	COG0431	NADPH-dependent FMN reductase
HLK66_RS06995	COG0726	polysaccharide deacetylase
HLK66_RS07015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HLK66_RS07025	COG1070	Carbohydrate kinase
HLK66_RS07035	COG2169	Transcriptional regulator
HLK66_RS07040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HLK66_RS07045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK66_RS07050	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HLK66_RS07055	COG1215	transferase activity, transferring glycosyl groups
HLK66_RS07060	COG1609	Transcriptional regulator
HLK66_RS07065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLK66_RS07070	COG0363	glucosamine-6-phosphate deaminase activity
HLK66_RS07075	COG2188	Transcriptional regulator
HLK66_RS07080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HLK66_RS07085	COG1595	DNA-templated transcription, initiation
HLK66_RS07090	COG3104	oligopeptide transport
HLK66_RS07110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLK66_RS07120	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLK66_RS07135	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS07135	COG3347	Dehydrogenase
HLK66_RS07150	COG1070	Carbohydrate kinase
HLK66_RS07155	COG4806	L-rhamnose isomerase
HLK66_RS07175	COG2972	Histidine kinase
HLK66_RS07195	COG4214	carbohydrate transport
HLK66_RS07200	COG1349	DNA-binding transcription factor activity
HLK66_RS07210	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_RS07215	COG0366	Alpha amylase catalytic
HLK66_RS07220	COG2190	(PTS) system
HLK66_RS07220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS07220	COG1263	PTS System
HLK66_RS07225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HLK66_RS07230	COG1442	glycosyl transferase family 8
HLK66_RS07235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLK66_RS07260	COG1216	Glycosyl transferase, family 2
HLK66_RS07265	COG3328	transposase activity
HLK66_RS07270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLK66_RS07275	COG3541	Predicted nucleotidyltransferase
HLK66_RS07285	COG1834	amidinotransferase
HLK66_RS07290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLK66_RS07295	COG1309	transcriptional regulator
HLK66_RS07300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLK66_RS07305	COG1523	belongs to the glycosyl hydrolase 13 family
HLK66_RS07320	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLK66_RS07325	COG1937	Protein conserved in bacteria
HLK66_RS07330	COG2210	Belongs to the sulfur carrier protein TusA family
HLK66_RS07335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLK66_RS07350	COG5577	PFAM Coat F domain
HLK66_RS07360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLK66_RS07365	COG3162	membrane
HLK66_RS07370	COG3546	catalase activity
HLK66_RS07375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HLK66_RS07410	COG2205	protein histidine kinase activity
HLK66_RS07415	COG0745	RESPONSE REGULATOR receiver
HLK66_RS07465	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLK66_RS07470	COG0840	transmembrane signaling receptor activity
HLK66_RS07475	COG0655	NAD(P)H dehydrogenase (quinone) activity
HLK66_RS07480	COG2207	Transcriptional regulator
HLK66_RS07480	COG4753	response regulator
HLK66_RS07485	COG2972	Histidine kinase
HLK66_RS07495	COG1175	transmembrane transport
HLK66_RS07530	COG2814	Major facilitator Superfamily
HLK66_RS07535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_RS07540	COG1116	anion transmembrane transporter activity
HLK66_RS07545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLK66_RS07550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLK66_RS07555	COG0697	spore germination
HLK66_RS07560	COG1609	Transcriptional regulator
HLK66_RS07565	COG4209	transmembrane transport
HLK66_RS07570	COG0395	ABC-type sugar transport system, permease component
HLK66_RS07580	COG1621	beta-fructofuranosidase activity
HLK66_RS07585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_RS07590	COG1621	beta-fructofuranosidase activity
HLK66_RS07595	COG1621	beta-fructofuranosidase activity
HLK66_RS07600	COG1621	beta-fructofuranosidase activity
HLK66_RS07605	COG1653	transport
HLK66_RS07610	COG2207	Transcriptional regulator
HLK66_RS07610	COG4753	response regulator
HLK66_RS07615	COG2972	Histidine kinase
HLK66_RS07625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLK66_RS07630	COG2271	Major facilitator Superfamily
HLK66_RS07635	COG0405	Gamma-glutamyltransferase
HLK66_RS07650	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS07655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLK66_RS07660	COG2146	nitrite reductase [NAD(P)H] activity
HLK66_RS07665	COG1587	Uroporphyrinogen-III synthase
HLK66_RS07665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLK66_RS07675	COG2116	formate transmembrane transporter activity
HLK66_RS07680	COG3604	Transcriptional regulator
HLK66_RS07690	COG2223	nitrite transmembrane transporter activity
HLK66_RS07720	COG0523	cobalamin synthesis protein
HLK66_RS07725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLK66_RS07735	COG3588	fructose-bisphosphate aldolase
HLK66_RS07770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK66_RS07780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS07790	COG1175	transmembrane transport
HLK66_RS07795	COG0395	ABC-type sugar transport system, permease component
HLK66_RS07805	COG0673	inositol 2-dehydrogenase activity
HLK66_RS07825	COG1082	Xylose isomerase domain protein TIM barrel
HLK66_RS07830	COG3773	Cell wall hydrolase
HLK66_RS07840	COG1136	(ABC) transporter
HLK66_RS07855	COG1732	Glycine betaine
HLK66_RS07865	COG0662	Cupin 2, conserved barrel domain protein
HLK66_RS07865	COG2207	Transcriptional regulator
HLK66_RS07885	COG1874	Beta-galactosidase
HLK66_RS07890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLK66_RS07895	COG3773	Cell wall hydrolase
HLK66_RS07905	COG1414	Transcriptional regulator
HLK66_RS07910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK66_RS07915	COG0129	dihydroxy-acid dehydratase activity
HLK66_RS07925	COG3507	Belongs to the glycosyl hydrolase 43 family
HLK66_RS07940	COG0583	DNA-binding transcription factor activity
HLK66_RS07960	COG3842	ATPase activity
HLK66_RS07980	COG0584	glycerophosphoryl diester phosphodiesterase
HLK66_RS07985	COG0584	glycerophosphoryl diester phosphodiesterase
HLK66_RS08000	COG0142	geranyltranstransferase activity
HLK66_RS08005	COG1234	tRNA 3'-trailer cleavage
HLK66_RS08015	COG0154	amidase activity
HLK66_RS08035	COG2508	Transcriptional regulator
HLK66_RS08040	COG1953	Uracil, thiamine, allantoin
HLK66_RS08060	COG1266	CAAX protease self-immunity
HLK66_RS08070	COG0720	synthase
HLK66_RS08080	COG0302	gtp cyclohydrolase
HLK66_RS08090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLK66_RS08115	COG0431	NADPH-dependent FMN reductase
HLK66_RS08130	COG0395	ABC-type sugar transport system, permease component
HLK66_RS08135	COG3507	Belongs to the glycosyl hydrolase 43 family
HLK66_RS08140	COG5578	integral membrane protein
HLK66_RS08145	COG3940	Belongs to the glycosyl hydrolase 43 family
HLK66_RS08165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HLK66_RS08170	COG2207	Transcriptional regulator
HLK66_RS08180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLK66_RS08195	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HLK66_RS08200	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLK66_RS08205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLK66_RS08215	COG1113	amino acid transport
HLK66_RS08220	COG4555	ABC transporter
HLK66_RS08255	COG5002	protein histidine kinase activity
HLK66_RS08255	COG3850	Histidine kinase
HLK66_RS08260	COG1136	(ABC) transporter
HLK66_RS08270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLK66_RS08280	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_RS08285	COG1595	DNA-templated transcription, initiation
HLK66_RS08315	COG0366	Alpha amylase catalytic
HLK66_RS08320	COG2017	converts alpha-aldose to the beta-anomer
HLK66_RS08325	COG1175	transmembrane transport
HLK66_RS08330	COG0395	ABC-type sugar transport system, permease component
HLK66_RS08340	COG3254	rhamnose metabolic process
HLK66_RS08345	COG5578	integral membrane protein
HLK66_RS08360	COG2972	Histidine kinase
HLK66_RS08365	COG2207	Transcriptional regulator
HLK66_RS08365	COG4753	response regulator
HLK66_RS08395	COG1266	CAAX protease self-immunity
HLK66_RS08400	COG1404	Belongs to the peptidase S8 family
HLK66_RS08405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLK66_RS08420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK66_RS08425	COG2169	Transcriptional regulator
HLK66_RS08435	COG0673	inositol 2-dehydrogenase activity
HLK66_RS08440	COG1082	Xylose isomerase domain protein TIM barrel
HLK66_RS08445	COG0673	inositol 2-dehydrogenase activity
HLK66_RS08450	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLK66_RS08465	COG1595	DNA-templated transcription, initiation
HLK66_RS08475	COG0772	Belongs to the SEDS family
HLK66_RS08485	COG0583	DNA-binding transcription factor activity
HLK66_RS08490	COG1063	alcohol dehydrogenase
HLK66_RS08495	COG2814	Major facilitator Superfamily
HLK66_RS08505	COG1113	amino acid transport
HLK66_RS08510	COG2205	protein histidine kinase activity
HLK66_RS08520	COG1252	NADH dehydrogenase
HLK66_RS08530	COG0778	Nitroreductase
HLK66_RS08535	COG0252	asparaginase activity
HLK66_RS08540	COG4193	domain, Protein
HLK66_RS08545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLK66_RS08550	COG0791	NLP P60 protein
HLK66_RS08550	COG3883	PFAM NLP P60 protein
HLK66_RS08555	COG1121	(ABC) transporter
HLK66_RS08560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLK66_RS08580	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HLK66_RS08595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HLK66_RS08600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS08605	COG1119	ATPase activity
HLK66_RS08610	COG0561	phosphatase activity
HLK66_RS08620	COG1585	Membrane protein implicated in regulation of membrane protease activity
HLK66_RS08625	COG2268	Band 7 protein
HLK66_RS08630	COG2113	Glycine betaine
HLK66_RS08635	COG4176	ABC-type proline glycine betaine transport system permease component
HLK66_RS08640	COG4175	Glycine betaine
HLK66_RS08640	COG0517	IMP dehydrogenase activity
HLK66_RS08645	COG1510	regulation of RNA biosynthetic process
HLK66_RS08660	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLK66_RS08665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HLK66_RS08670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_RS08675	COG4597	amino acid ABC transporter
HLK66_RS08685	COG1126	abc transporter atp-binding protein
HLK66_RS08695	COG0861	Integral membrane protein TerC family
HLK66_RS08705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLK66_RS08720	COG3594	Acyltransferase
HLK66_RS08725	COG5002	protein histidine kinase activity
HLK66_RS08735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLK66_RS08750	COG3852	Histidine kinase
HLK66_RS08755	COG1846	Transcriptional regulator
HLK66_RS08765	COG0542	response to heat
HLK66_RS08770	COG3949	Membrane
HLK66_RS08785	COG4873	Protein conserved in bacteria
HLK66_RS08805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLK66_RS08810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLK66_RS08815	COG2084	Dehydrogenase
HLK66_RS08820	COG0436	Aminotransferase
HLK66_RS08840	COG0835	chemotaxis
HLK66_RS08840	COG0784	Response regulator, receiver
HLK66_RS08855	COG5001	Diguanylate cyclase
HLK66_RS08855	COG3300	MHYT domain
HLK66_RS08860	COG4990	cell redox homeostasis
HLK66_RS08865	COG2200	EAL domain
HLK66_RS08880	COG4703	Protein of unknown function (DUF1797)
HLK66_RS08885	COG0517	IMP dehydrogenase activity
HLK66_RS08890	COG0583	DNA-binding transcription factor activity
HLK66_RS08895	COG2171	N-acyltransferase activity
HLK66_RS08905	COG0668	transmembrane transport
HLK66_RS08920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_RS08925	COG0569	domain protein
HLK66_RS08935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLK66_RS08960	COG0022	dehydrogenase e1 component
HLK66_RS08965	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLK66_RS08985	COG1982	Orn Lys Arg decarboxylase major
HLK66_RS08995	COG4493	Belongs to the UPF0637 family
HLK66_RS09005	COG0483	inositol monophosphate 1-phosphatase activity
HLK66_RS09020	COG4896	Protein conserved in bacteria
HLK66_RS09030	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HLK66_RS09035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLK66_RS09045	COG0772	Belongs to the SEDS family
HLK66_RS09060	COG2340	Cysteine-rich secretory protein family
HLK66_RS09080	COG3679	Belongs to the UPF0342 family
HLK66_RS09085	COG4471	UPF0298 protein
HLK66_RS09090	COG0742	ribosomal rna small subunit methyltransferase
HLK66_RS09095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HLK66_RS09100	COG3314	Sporulation integral membrane protein YlbJ
HLK66_RS09105	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLK66_RS09110	COG1323	Belongs to the UPF0348 family
HLK66_RS09115	COG1399	metal-binding, possibly nucleic acid-binding protein
HLK66_RS09120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HLK66_RS09125	COG1683	Conserved Protein
HLK66_RS09145	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HLK66_RS09150	COG3344	reverse transcriptase
HLK66_RS09155	COG2001	Belongs to the MraZ family
HLK66_RS09180	COG0768	penicillin binding
HLK66_RS09185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLK66_RS09195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLK66_RS09200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HLK66_RS09205	COG0772	Belongs to the SEDS family
HLK66_RS09210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLK66_RS09215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HLK66_RS09220	COG3879	Bacterial protein of unknown function (DUF881)
HLK66_RS09225	COG3879	Bacterial protein of unknown function (DUF881)
HLK66_RS09230	COG3856	small basic protein
HLK66_RS09235	COG0849	cell division
HLK66_RS09240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLK66_RS09245	COG3344	reverse transcriptase
HLK66_RS09255	COG1191	sigma factor activity
HLK66_RS09260	COG1191	sigma factor activity
HLK66_RS09270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLK66_RS09275	COG1799	cell septum assembly
HLK66_RS09280	COG0762	integral membrane protein
HLK66_RS09285	COG2302	S4 RNA-binding domain
HLK66_RS09290	COG3599	regulation of cell shape
HLK66_RS09295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLK66_RS09300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLK66_RS09305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HLK66_RS09310	COG0564	pseudouridine synthase activity
HLK66_RS09315	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HLK66_RS09325	COG0540	Belongs to the ATCase OTCase family
HLK66_RS09340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLK66_RS09350	COG0167	dihydroorotate dehydrogenase activity
HLK66_RS09370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLK66_RS09375	COG1561	YicC-like family, N-terminal region
HLK66_RS09385	COG0194	GDP metabolic process
HLK66_RS09395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLK66_RS09400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLK66_RS09420	COG3833	ABC-type maltose transport systems, permease component
HLK66_RS09430	COG3250	beta-galactosidase activity
HLK66_RS09435	COG3250	beta-galactosidase activity
HLK66_RS09445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLK66_RS09450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLK66_RS09450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLK66_RS09460	COG0631	protein serine/threonine phosphatase activity
HLK66_RS09465	COG0515	serine threonine protein kinase
HLK66_RS09465	COG2815	serine threonine protein kinase
HLK66_RS09470	COG1162	GTPase activity
HLK66_RS09475	COG1564	THIamine pyrophosphokinase
HLK66_RS09485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HLK66_RS09490	COG1302	Protein conserved in bacteria
HLK66_RS09495	COG1461	Dihydroxyacetone kinase
HLK66_RS09500	COG1760	l-serine dehydratase
HLK66_RS09505	COG1760	l-serine dehydratase
HLK66_RS09515	COG1349	DNA-binding transcription factor activity
HLK66_RS09520	COG0416	fatty acid biosynthetic process
HLK66_RS09525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLK66_RS09530	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS09535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLK66_RS09540	COG0571	ribonuclease III activity
HLK66_RS09545	COG1196	nuclear chromosome segregation
HLK66_RS09550	COG0552	protein localization to endoplasmic reticulum
HLK66_RS09565	COG1131	(ABC) transporter
HLK66_RS09580	COG0714	Associated with various cellular activities
HLK66_RS09600	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HLK66_RS09605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLK66_RS09615	COG1837	Belongs to the UPF0109 family
HLK66_RS09625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLK66_RS09640	COG0681	Belongs to the peptidase S26 family
HLK66_RS09645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HLK66_RS09660	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLK66_RS09665	COG0045	succinate-CoA ligase (ADP-forming) activity
HLK66_RS09670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HLK66_RS09675	COG0758	DNA mediated transformation
HLK66_RS09680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLK66_RS09685	COG4974	Belongs to the 'phage' integrase family
HLK66_RS09695	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HLK66_RS09700	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HLK66_RS09705	COG1815	bacterial-type flagellum-dependent cell motility
HLK66_RS09710	COG1558	bacterial-type flagellum-dependent cell motility
HLK66_RS09715	COG1677	Flagellar hook-basal body complex protein FliE
HLK66_RS09720	COG1766	The M ring may be actively involved in energy transduction
HLK66_RS09725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLK66_RS09730	COG1317	bacterial-type flagellum organization
HLK66_RS09735	COG1157	protein secretion by the type III secretion system
HLK66_RS09740	COG2882	bacterial-type flagellum organization
HLK66_RS09755	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HLK66_RS09765	COG4786	Flagellar basal body rod
HLK66_RS09770	COG1582	Flagellar protein (FlbD)
HLK66_RS09775	COG1580	Controls the rotational direction of flagella during chemotaxis
HLK66_RS09780	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLK66_RS09785	COG1776	CheC inhibitor of MCP methylation
HLK66_RS09785	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLK66_RS09790	COG2201	protein-glutamate methylesterase activity
HLK66_RS09795	COG3190	flagellar
HLK66_RS09800	COG1338	Plays a role in the flagellum-specific transport system
HLK66_RS09805	COG1987	bacterial-type flagellum assembly
HLK66_RS09810	COG1684	flagellar biosynthetic protein fliR
HLK66_RS09815	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLK66_RS09820	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLK66_RS09825	COG1419	protein localization to endoplasmic reticulum
HLK66_RS09830	COG0455	bacterial-type flagellum organization
HLK66_RS09835	COG2201	protein-glutamate methylesterase activity
HLK66_RS09840	COG0643	Histidine kinase
HLK66_RS09840	COG2198	Histidine kinase
HLK66_RS09845	COG0835	chemotaxis
HLK66_RS09850	COG1776	CheC inhibitor of MCP methylation
HLK66_RS09855	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HLK66_RS09860	COG1191	sigma factor activity
HLK66_RS09890	COG0233	cytoplasmic translational termination
HLK66_RS09900	COG4589	Belongs to the CDS family
HLK66_RS09910	COG0750	zinc metalloprotease
HLK66_RS09915	COG0442	prolyl-tRNA aminoacylation
HLK66_RS09920	COG2176	DNA-directed DNA polymerase activity
HLK66_RS09925	COG0779	Required for maturation of 30S ribosomal subunits
HLK66_RS09930	COG0195	Participates in both transcription termination and antitermination
HLK66_RS09935	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HLK66_RS09940	COG1358	cellular component organization or biogenesis
HLK66_RS09950	COG1550	Protein conserved in bacteria
HLK66_RS09960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLK66_RS09965	COG0196	riboflavin kinase activity
HLK66_RS09970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HLK66_RS09975	COG1185	polyribonucleotide nucleotidyltransferase activity
HLK66_RS09980	COG0726	polysaccharide deacetylase
HLK66_RS09985	COG0612	Peptidase, M16
HLK66_RS09990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK66_RS09995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLK66_RS10000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLK66_RS10005	COG0527	aspartate kinase activity
HLK66_RS10010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK66_RS10015	COG1113	amino acid transport
HLK66_RS10020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLK66_RS10025	COG0740	serine-type endopeptidase activity
HLK66_RS10040	COG4980	gas vesicle protein
HLK66_RS10040	COG1674	ftsk spoiiie
HLK66_RS10045	COG2188	Transcriptional regulator
HLK66_RS10080	COG0612	Peptidase, M16
HLK66_RS10085	COG0612	Peptidase, M16
HLK66_RS10090	COG0300	oxidoreductase activity
HLK66_RS10105	COG1426	Protein conserved in bacteria
HLK66_RS10110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLK66_RS10115	COG1546	Belongs to the CinA family
HLK66_RS10115	COG1058	Belongs to the CinA family
HLK66_RS10120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HLK66_RS10125	COG1418	mRNA catabolic process
HLK66_RS10130	COG3344	reverse transcriptase
HLK66_RS10135	COG1692	metallophosphoesterase
HLK66_RS10140	COG2359	stage V sporulation protein S
HLK66_RS10150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLK66_RS10155	COG4550	Control of competence regulator ComK, YlbF/YmcA
HLK66_RS10160	COG3344	reverse transcriptase
HLK66_RS10190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLK66_RS10195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLK66_RS10210	COG3711	transcriptional antiterminator
HLK66_RS10210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS10225	COG3711	transcriptional antiterminator
HLK66_RS10225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS10230	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_RS10265	COG2217	Heavy metal translocating P-type atpase
HLK66_RS10275	COG0586	Pfam SNARE associated Golgi protein
HLK66_RS10290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK66_RS10305	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLK66_RS10310	COG2271	Major facilitator Superfamily
HLK66_RS10315	COG1846	Transcriptional regulator
HLK66_RS10315	COG0456	acetyltransferase
HLK66_RS10320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLK66_RS10325	COG0583	DNA-binding transcription factor activity
HLK66_RS10340	COG2318	DinB family
HLK66_RS10345	COG2207	Transcriptional regulator
HLK66_RS10355	COG1309	transcriptional regulator
HLK66_RS10360	COG3773	Cell wall hydrolase
HLK66_RS10395	COG0531	amino acid
HLK66_RS10410	COG0640	Transcriptional regulator
HLK66_RS10430	COG3848	Pyruvate phosphate dikinase
HLK66_RS10430	COG0574	Belongs to the PEP-utilizing enzyme family
HLK66_RS10435	COG1794	racemase activity, acting on amino acids and derivatives
HLK66_RS10440	COG0076	glutamate decarboxylase activity
HLK66_RS10445	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS10460	COG0768	penicillin binding
HLK66_RS10490	COG0723	plastoquinol--plastocyanin reductase activity
HLK66_RS10490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLK66_RS10520	COG3715	PTS system
HLK66_RS10525	COG3716	PTS system mannose fructose sorbose family IID component
HLK66_RS10530	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS10530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS10535	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HLK66_RS10565	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS10575	COG2207	Transcriptional regulator
HLK66_RS10575	COG3708	Transcriptional regulator
HLK66_RS10580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_RS10610	COG3546	catalase activity
HLK66_RS10635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_RS10670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLK66_RS10675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HLK66_RS10680	COG0217	transcriptional regulatory protein
HLK66_RS10690	COG0789	Transcriptional regulator
HLK66_RS10730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HLK66_RS10740	COG0454	-acetyltransferase
HLK66_RS10745	COG2814	Major facilitator Superfamily
HLK66_RS10755	COG2318	DinB family
HLK66_RS10780	COG0456	acetyltransferase
HLK66_RS10805	COG0596	Alpha beta hydrolase
HLK66_RS10820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS10850	COG0640	Transcriptional regulator
HLK66_RS10865	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS10875	COG1309	transcriptional regulator
HLK66_RS10880	COG2814	Major facilitator Superfamily
HLK66_RS10900	COG5002	protein histidine kinase activity
HLK66_RS10960	COG2267	carboxylic ester hydrolase activity
HLK66_RS10985	COG3708	Transcriptional regulator
HLK66_RS10985	COG2207	Transcriptional regulator
HLK66_RS11000	COG0018	arginyl-trna synthetase
HLK66_RS11005	COG4549	nuclear export factor GLE1
HLK66_RS11015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS11025	COG0592	DNA-directed DNA polymerase activity
HLK66_RS11030	COG2329	Antibiotic biosynthesis monooxygenase
HLK66_RS11090	COG2226	methyltransferase
HLK66_RS11110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS11130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLK66_RS11135	COG0022	dehydrogenase e1 component
HLK66_RS11140	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLK66_RS11145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLK66_RS11150	COG0316	Belongs to the HesB IscA family
HLK66_RS11180	COG3655	Transcriptional regulator
HLK66_RS11185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLK66_RS11200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLK66_RS11205	COG3002	Belongs to the UPF0753 family
HLK66_RS11210	COG0288	reversible hydration of carbon dioxide
HLK66_RS11215	COG5609	conserved protein (DUF2294)
HLK66_RS11265	COG2076	Multidrug Resistance protein
HLK66_RS11270	COG2076	Multidrug Resistance protein
HLK66_RS11275	COG1309	transcriptional regulator
HLK66_RS11290	COG0412	Dienelactone hydrolase
HLK66_RS11320	COG0583	DNA-binding transcription factor activity
HLK66_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS11370	COG5002	protein histidine kinase activity
HLK66_RS11375	COG0494	nUDIX hydrolase
HLK66_RS11425	COG2267	carboxylic ester hydrolase activity
HLK66_RS11435	COG2244	polysaccharide biosynthetic process
HLK66_RS11480	COG1104	cysteine desulfurase activity
HLK66_RS11485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HLK66_RS11490	COG0157	Belongs to the NadC ModD family
HLK66_RS11495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HLK66_RS11505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HLK66_RS11515	COG0464	growth
HLK66_RS11520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLK66_RS11525	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HLK66_RS11530	COG0789	Transcriptional regulator
HLK66_RS11535	COG0174	glutamine synthetase
HLK66_RS11555	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HLK66_RS11590	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HLK66_RS11635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLK66_RS11645	COG2080	2 iron, 2 sulfur cluster binding
HLK66_RS11660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLK66_RS11665	COG3344	reverse transcriptase
HLK66_RS11675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLK66_RS11685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLK66_RS11690	COG4224	UPF0291 protein
HLK66_RS11695	COG3344	reverse transcriptase
HLK66_RS11710	COG3763	UPF0154 protein
HLK66_RS11730	COG1132	(ABC) transporter
HLK66_RS11735	COG1132	(ABC) transporter
HLK66_RS11745	COG0785	Cytochrome C biogenesis protein
HLK66_RS11750	COG2201	protein-glutamate methylesterase activity
HLK66_RS11755	COG4846	Membrane protein involved in cytochrome C biogenesis
HLK66_RS11790	COG0420	3'-5' exonuclease activity
HLK66_RS11800	COG1876	peptidase activity
HLK66_RS11805	COG1363	Peptidase, m42
HLK66_RS11810	COG1368	sulfuric ester hydrolase activity
HLK66_RS11815	COG3973	AAA domain
HLK66_RS11820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLK66_RS11830	COG3764	Sortase (surface protein transpeptidase)
HLK66_RS11845	COG0456	acetyltransferase
HLK66_RS11850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS11860	COG3344	reverse transcriptase
HLK66_RS11870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLK66_RS11880	COG5577	PFAM Coat F domain
HLK66_RS11885	COG1063	alcohol dehydrogenase
HLK66_RS11895	COG5577	PFAM Coat F domain
HLK66_RS11900	COG1486	melibiose metabolic process
HLK66_RS11915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLK66_RS11920	COG1247	-acetyltransferase
HLK66_RS11935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS11945	COG1227	inorganic diphosphatase activity
HLK66_RS11950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_RS11965	COG0464	growth
HLK66_RS11985	COG4841	protein insertion into membrane
HLK66_RS11990	COG2843	Capsule synthesis protein
HLK66_RS11995	COG3852	Histidine kinase
HLK66_RS12000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HLK66_RS12025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLK66_RS12025	COG3153	acetyltransferase
HLK66_RS12035	COG5504	Zn-dependent protease
HLK66_RS12040	COG1846	Transcriptional regulator
HLK66_RS12045	COG0477	Major facilitator Superfamily
HLK66_RS12050	COG3344	reverse transcriptase
HLK66_RS12055	COG2755	lipolytic protein G-D-S-L family
HLK66_RS12075	COG0646	methionine synthase
HLK66_RS12075	COG1410	methionine synthase
HLK66_RS12080	COG0646	methionine synthase
HLK66_RS12080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLK66_RS12085	COG0626	cystathionine gamma-synthase activity
HLK66_RS12090	COG0626	cystathionine gamma-synthase activity
HLK66_RS12100	COG0745	RESPONSE REGULATOR receiver
HLK66_RS12105	COG5002	protein histidine kinase activity
HLK66_RS12110	COG0567	Dehydrogenase, E1 component
HLK66_RS12115	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLK66_RS12135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HLK66_RS12155	COG1335	isochorismatase
HLK66_RS12175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLK66_RS12185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HLK66_RS12185	COG0392	lysyltransferase activity
HLK66_RS12190	COG1686	Belongs to the peptidase S11 family
HLK66_RS12195	COG3344	reverse transcriptase
HLK66_RS12200	COG0488	(ABC) transporter
HLK66_RS12205	COG2116	formate transmembrane transporter activity
HLK66_RS12230	COG0514	ATP-dependent DNA helicase (RecQ)
HLK66_RS12235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLK66_RS12250	COG3584	3D domain protein
HLK66_RS12250	COG1388	LysM domain
HLK66_RS12265	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HLK66_RS12275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HLK66_RS12280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLK66_RS12285	COG2080	2 iron, 2 sulfur cluster binding
HLK66_RS12290	COG3195	allantoin biosynthetic process
HLK66_RS12290	COG3648	Uricase
HLK66_RS12295	COG2351	hydroxyisourate hydrolase activity
HLK66_RS12300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLK66_RS12310	COG2223	nitrite transmembrane transporter activity
HLK66_RS12325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLK66_RS12335	COG0561	phosphatase activity
HLK66_RS12345	COG1164	Oligoendopeptidase f
HLK66_RS12350	COG0583	DNA-binding transcription factor activity
HLK66_RS12355	COG0070	glutamate synthase
HLK66_RS12355	COG0069	glutamate synthase activity
HLK66_RS12355	COG0067	glutamate synthase
HLK66_RS12360	COG0493	'glutamate synthase
HLK66_RS12365	COG1418	mRNA catabolic process
HLK66_RS12375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLK66_RS12380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLK66_RS12385	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS12390	COG0861	Integral membrane protein TerC family
HLK66_RS12395	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HLK66_RS12410	COG0681	Belongs to the peptidase S26 family
HLK66_RS12420	COG1725	Transcriptional regulator
HLK66_RS12435	COG4974	Belongs to the 'phage' integrase family
HLK66_RS12450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HLK66_RS12455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLK66_RS12455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLK66_RS12460	COG0307	riboflavin synthase, alpha
HLK66_RS12465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLK66_RS12470	COG0708	Exodeoxyribonuclease III
HLK66_RS12475	COG0346	lactoylglutathione lyase activity
HLK66_RS12480	COG0561	phosphatase activity
HLK66_RS12500	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_RS12520	COG1733	regulation of RNA biosynthetic process
HLK66_RS12525	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLK66_RS12535	COG2027	D-alanyl-D-alanine carboxypeptidase
HLK66_RS12545	COG3341	Caulimovirus viroplasmin
HLK66_RS12545	COG0328	RNA-DNA hybrid ribonuclease activity
HLK66_RS12550	COG3275	phosphorelay sensor kinase activity
HLK66_RS12560	COG1966	Carbon starvation protein
HLK66_RS12570	COG3300	MHYT domain
HLK66_RS12570	COG5001	Diguanylate cyclase
HLK66_RS12575	COG2066	Belongs to the glutaminase family
HLK66_RS12580	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HLK66_RS12590	COG0840	transmembrane signaling receptor activity
HLK66_RS12600	COG1280	lysine exporter protein (LysE YggA)
HLK66_RS12605	COG0024	Methionine aminopeptidase
HLK66_RS12615	COG0531	amino acid
HLK66_RS12640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_RS12640	COG1042	CoA-binding domain protein
HLK66_RS12640	COG0045	succinate-CoA ligase (ADP-forming) activity
HLK66_RS12645	COG0753	catalase activity
HLK66_RS12650	COG0326	Molecular chaperone. Has ATPase activity
HLK66_RS12655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLK66_RS12660	COG1280	lysine exporter protein (LysE YggA)
HLK66_RS12705	COG3689	TIGRFAM TIGR03943 family protein
HLK66_RS12710	COG0701	Predicted permease
HLK66_RS12725	COG0492	ferredoxin-NADP+ reductase activity
HLK66_RS12730	COG1609	Transcriptional regulator
HLK66_RS12735	COG1621	beta-fructofuranosidase activity
HLK66_RS12750	COG0583	DNA-binding transcription factor activity
HLK66_RS12765	COG1349	DNA-binding transcription factor activity
HLK66_RS12770	COG4977	sequence-specific DNA binding
HLK66_RS12785	COG1051	belongs to the nudix hydrolase family
HLK66_RS12790	COG4473	ABC transporter
HLK66_RS12795	COG1131	(ABC) transporter
HLK66_RS12800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLK66_RS12820	COG0406	alpha-ribazole phosphatase activity
HLK66_RS12850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLK66_RS12860	COG1832	CoA-binding protein
HLK66_RS12880	COG3858	chitin binding
HLK66_RS12895	COG3859	Proton-coupled thiamine transporter YuaJ
HLK66_RS12905	COG1309	transcriptional regulator
HLK66_RS12920	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK66_RS12925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLK66_RS12930	COG0204	Acyl-transferase
HLK66_RS12935	COG0561	phosphatase activity
HLK66_RS12940	COG1349	DNA-binding transcription factor activity
HLK66_RS12955	COG1482	cell wall glycoprotein biosynthetic process
HLK66_RS12960	COG1404	Belongs to the peptidase S8 family
HLK66_RS12965	COG2814	Major facilitator Superfamily
HLK66_RS12990	COG1268	BioY protein
HLK66_RS12995	COG2372	response to copper ion
HLK66_RS12995	COG1276	copper resistance
HLK66_RS13015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLK66_RS13020	COG0737	Belongs to the 5'-nucleotidase family
HLK66_RS13030	COG0561	phosphatase activity
HLK66_RS13040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_RS13045	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HLK66_RS13060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_RS13070	COG1011	Hydrolase
HLK66_RS13075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLK66_RS13105	COG1695	Transcriptional regulator
HLK66_RS13115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HLK66_RS13120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HLK66_RS13125	COG0561	phosphatase activity
HLK66_RS13130	COG0697	spore germination
HLK66_RS13135	COG1132	(ABC) transporter
HLK66_RS13140	COG0583	DNA-binding transcription factor activity
HLK66_RS13165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLK66_RS13170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLK66_RS13170	COG0512	Glutamine amidotransferase of anthranilate synthase
HLK66_RS13175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLK66_RS13180	COG2258	MOSC domain
HLK66_RS13185	COG2814	Major facilitator Superfamily
HLK66_RS13190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS13190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_RS13190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_RS13195	COG1105	Belongs to the carbohydrate kinase PfkB family
HLK66_RS13200	COG1349	DNA-binding transcription factor activity
HLK66_RS13215	COG2176	DNA-directed DNA polymerase activity
HLK66_RS13225	COG0004	ammonium transporteR
HLK66_RS13240	COG0351	phosphomethylpyrimidine kinase
HLK66_RS13255	COG0701	Predicted permease
HLK66_RS13260	COG0523	cobalamin synthesis protein
HLK66_RS13265	COG0840	transmembrane signaling receptor activity
HLK66_RS13275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLK66_RS13295	COG2267	carboxylic ester hydrolase activity
HLK66_RS13300	COG0596	Alpha beta hydrolase
HLK66_RS13315	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HLK66_RS13320	COG1737	Transcriptional regulator
HLK66_RS13325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS13325	COG1263	PTS System
HLK66_RS13340	COG1609	Transcriptional regulator
HLK66_RS13350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLK66_RS13355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLK66_RS13360	COG0523	cobalamin synthesis protein
HLK66_RS13405	COG2849	repeat protein
HLK66_RS13470	COG3739	integral membrane protein
HLK66_RS13475	COG3655	Transcriptional regulator
HLK66_RS13490	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HLK66_RS13495	COG5646	InterPro IPR014922
HLK66_RS13525	COG1595	DNA-templated transcription, initiation
HLK66_RS13540	COG1357	PFAM Pentapeptide repeats (8 copies)
HLK66_RS13565	COG2155	Conserved Protein
HLK66_RS13570	COG2733	membrane
HLK66_RS13590	COG0384	phenazine biosynthesis protein PhzF
HLK66_RS13615	COG2207	Transcriptional regulator
HLK66_RS13615	COG3708	Transcriptional regulator
HLK66_RS13620	COG1115	amino acid carrier protein
HLK66_RS13650	COG1690	Belongs to the RtcB family
HLK66_RS13655	COG4377	Putative membrane peptidase family (DUF2324)
HLK66_RS13670	COG0586	Pfam SNARE associated Golgi protein
HLK66_RS13690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_RS13700	COG0406	alpha-ribazole phosphatase activity
HLK66_RS13705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_RS13755	COG0726	polysaccharide deacetylase
HLK66_RS13780	COG0583	DNA-binding transcription factor activity
HLK66_RS13790	COG1346	cytolysis
HLK66_RS13815	COG0513	Belongs to the DEAD box helicase family
HLK66_RS13825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLK66_RS13830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLK66_RS13840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLK66_RS13845	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HLK66_RS13850	COG0671	phosphoesterase, PA-phosphatase related
HLK66_RS13855	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HLK66_RS13860	COG1793	dna ligase
HLK66_RS13860	COG3285	dna ligase
HLK66_RS13870	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HLK66_RS13875	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HLK66_RS13905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLK66_RS13910	COG0640	Transcriptional regulator
HLK66_RS13915	COG0534	Mate efflux family protein
HLK66_RS13935	COG2340	Cysteine-rich secretory protein family
HLK66_RS13950	COG0523	cobalamin synthesis protein
HLK66_RS13955	COG3409	Peptidoglycan-binding domain 1 protein
HLK66_RS13955	COG0793	Belongs to the peptidase S41A family
HLK66_RS13960	COG1876	peptidase activity
HLK66_RS13990	COG4479	Belongs to the UPF0346 family
HLK66_RS14000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLK66_RS14025	COG2755	lipolytic protein G-D-S-L family
HLK66_RS14030	COG5002	protein histidine kinase activity
HLK66_RS14035	COG1307	EDD domain protein, DegV family
HLK66_RS14040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLK66_RS14045	COG1272	protein, Hemolysin III
HLK66_RS14050	COG3716	PTS system mannose fructose sorbose family IID component
HLK66_RS14055	COG3715	PTS system
HLK66_RS14060	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS14075	COG2188	Transcriptional regulator
HLK66_RS14080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLK66_RS14095	COG2310	stress, protein
HLK66_RS14100	COG2310	stress, protein
HLK66_RS14105	COG3853	Toxic anion resistance protein (TelA)
HLK66_RS14125	COG1358	cellular component organization or biogenesis
HLK66_RS14140	COG0861	Integral membrane protein TerC family
HLK66_RS14145	COG2310	stress, protein
HLK66_RS14155	COG2521	methyltransferase
HLK66_RS14155	COG2136	Putative SAM-dependent methyltransferase
HLK66_RS14165	COG1413	lyase activity
HLK66_RS14175	COG1418	mRNA catabolic process
HLK66_RS14195	COG0386	Belongs to the glutathione peroxidase family
HLK66_RS14210	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HLK66_RS14225	COG1321	iron dependent repressor
HLK66_RS14230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLK66_RS14230	COG0551	DNA topoisomerase type I activity
HLK66_RS14235	COG4129	membrane
HLK66_RS14250	COG1278	Cold shock
HLK66_RS14260	COG0328	RNA-DNA hybrid ribonuclease activity
HLK66_RS14265	COG0328	RNA-DNA hybrid ribonuclease activity
HLK66_RS14275	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HLK66_RS14285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLK66_RS14295	COG1131	(ABC) transporter
HLK66_RS14310	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLK66_RS14320	COG3344	reverse transcriptase
HLK66_RS14325	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HLK66_RS14330	COG1199	ATP-dependent helicase activity
HLK66_RS14340	COG0116	Belongs to the methyltransferase superfamily
HLK66_RS14355	COG4474	Belongs to the UPF0398 family
HLK66_RS14365	COG3359	exonuclease
HLK66_RS14375	COG2267	carboxylic ester hydrolase activity
HLK66_RS14380	COG0071	Belongs to the small heat shock protein (HSP20) family
HLK66_RS14415	COG3331	DNA recombination
HLK66_RS14420	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLK66_RS14420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLK66_RS14430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLK66_RS14435	COG3935	DnaD domain protein
HLK66_RS14440	COG0017	Asparaginyl-tRNA synthetase
HLK66_RS14445	COG0436	Aminotransferase
HLK66_RS14455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLK66_RS14455	COG1199	ATP-dependent helicase activity
HLK66_RS14460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HLK66_RS14465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HLK66_RS14470	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HLK66_RS14480	COG0617	tRNA 3'-terminal CCA addition
HLK66_RS14485	COG0438	transferase activity, transferring glycosyl groups
HLK66_RS14490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLK66_RS14500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HLK66_RS14505	COG1694	Mazg nucleotide pyrophosphohydrolase
HLK66_RS14510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_RS14520	COG2223	nitrite transmembrane transporter activity
HLK66_RS14525	COG2738	Putative neutral zinc metallopeptidase
HLK66_RS14535	COG4347	Protein of unknown function (DUF1405)
HLK66_RS14540	COG5582	Belongs to the UPF0302 family
HLK66_RS14545	COG0457	Tetratricopeptide repeat
HLK66_RS14555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLK66_RS14560	COG0287	Prephenate dehydrogenase
HLK66_RS14565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLK66_RS14570	COG4401	Chorismate mutase type I
HLK66_RS14575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HLK66_RS14585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLK66_RS14590	COG0105	UTP biosynthetic process
HLK66_RS14595	COG0142	geranyltranstransferase activity
HLK66_RS14600	COG2226	methyltransferase
HLK66_RS14605	COG0142	geranyltranstransferase activity
HLK66_RS14610	COG0776	regulation of translation
HLK66_RS14615	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLK66_RS14620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HLK66_RS14625	COG1160	GTP binding
HLK66_RS14645	COG0539	negative regulation of cytoplasmic translation
HLK66_RS14665	COG2959	enzyme of heme biosynthesis
HLK66_RS14670	COG3409	Peptidoglycan-binding domain 1 protein
HLK66_RS14670	COG3773	Cell wall hydrolase
HLK66_RS14675	COG2339	peptidase activity
HLK66_RS14680	COG0492	ferredoxin-NADP+ reductase activity
HLK66_RS14685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLK66_RS14690	COG4862	establishment of competence for transformation
HLK66_RS14695	COG1408	metallophosphoesterase
HLK66_RS14710	COG3546	catalase activity
HLK66_RS14725	COG1266	CAAX protease self-immunity
HLK66_RS14730	COG0514	ATP-dependent DNA helicase (RecQ)
HLK66_RS14740	COG1141	Ferredoxin
HLK66_RS14745	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HLK66_RS14750	COG0739	heme binding
HLK66_RS14765	COG1595	DNA-templated transcription, initiation
HLK66_RS14770	COG5002	protein histidine kinase activity
HLK66_RS14775	COG0745	RESPONSE REGULATOR receiver
HLK66_RS14780	COG1187	pseudouridine synthase activity
HLK66_RS14785	COG0700	Nucleoside recognition
HLK66_RS14790	COG2715	membrane protein required for spore maturation
HLK66_RS14795	COG1686	Belongs to the peptidase S11 family
HLK66_RS14800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLK66_RS14805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLK66_RS14810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HLK66_RS14815	COG1547	Domain of unknown function (DUF309)
HLK66_RS14825	COG4086	secreted protein
HLK66_RS14840	COG0697	spore germination
HLK66_RS14865	COG2172	sigma factor antagonist activity
HLK66_RS14875	COG1686	Belongs to the peptidase S11 family
HLK66_RS14880	COG0024	Methionine aminopeptidase
HLK66_RS14885	COG1595	DNA-templated transcription, initiation
HLK66_RS14905	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HLK66_RS14940	COG4974	Belongs to the 'phage' integrase family
HLK66_RS14950	COG0735	belongs to the Fur family
HLK66_RS14955	COG1300	Membrane
HLK66_RS14965	COG1379	DNA repair
HLK66_RS14980	COG0667	Aldo Keto reductase
HLK66_RS15000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS15005	COG0456	acetyltransferase
HLK66_RS15010	COG0346	lactoylglutathione lyase activity
HLK66_RS15015	COG1078	dGTPase activity
HLK66_RS15045	COG2271	Major facilitator Superfamily
HLK66_RS15050	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS15055	COG1063	alcohol dehydrogenase
HLK66_RS15060	COG4948	Mandelate Racemase Muconate Lactonizing
HLK66_RS15105	COG1595	DNA-templated transcription, initiation
HLK66_RS15130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_RS15135	COG3620	sequence-specific DNA binding
HLK66_RS15165	COG1764	response to oxidative stress
HLK66_RS15170	COG1073	alpha beta
HLK66_RS15175	COG2814	Major facilitator Superfamily
HLK66_RS15180	COG0640	Transcriptional regulator
HLK66_RS15225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLK66_RS15230	COG2814	Major facilitator Superfamily
HLK66_RS15235	COG1846	Transcriptional regulator
HLK66_RS15245	COG0300	oxidoreductase activity
HLK66_RS15255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLK66_RS15260	COG1234	tRNA 3'-trailer cleavage
HLK66_RS15265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HLK66_RS15270	COG1408	metallophosphoesterase
HLK66_RS15280	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HLK66_RS15285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLK66_RS15295	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLK66_RS15305	COG1376	ErfK ybiS ycfS ynhG family protein
HLK66_RS15310	COG1126	abc transporter atp-binding protein
HLK66_RS15315	COG0765	amino acid transport
HLK66_RS15320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_RS15330	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLK66_RS15335	COG0022	dehydrogenase e1 component
HLK66_RS15340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLK66_RS15345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLK66_RS15350	COG3426	butyrate kinase activity
HLK66_RS15355	COG3829	transcription factor binding
HLK66_RS15355	COG3290	protein histidine kinase activity
HLK66_RS15360	COG0584	glycerophosphoryl diester phosphodiesterase
HLK66_RS15375	COG0745	RESPONSE REGULATOR receiver
HLK66_RS15380	COG1575	Belongs to the MenA family. Type 1 subfamily
HLK66_RS15385	COG0750	zinc metalloprotease
HLK66_RS15390	COG0497	DNA recombination
HLK66_RS15395	COG1438	arginine binding
HLK66_RS15400	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HLK66_RS15405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLK66_RS15410	COG0142	geranyltranstransferase activity
HLK66_RS15415	COG1722	exodeoxyribonuclease VII activity
HLK66_RS15430	COG1302	Protein conserved in bacteria
HLK66_RS15435	COG0439	Biotin carboxylase
HLK66_RS15440	COG0511	ligase activity, forming carbon-carbon bonds
HLK66_RS15480	COG3854	ATPases associated with a variety of cellular activities
HLK66_RS15490	COG1785	Belongs to the alkaline phosphatase family
HLK66_RS15500	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS15505	COG1501	Belongs to the glycosyl hydrolase 31 family
HLK66_RS15520	COG0395	ABC-type sugar transport system, permease component
HLK66_RS15525	COG4209	transmembrane transport
HLK66_RS15540	COG4753	response regulator
HLK66_RS15540	COG2207	Transcriptional regulator
HLK66_RS15545	COG2972	Histidine kinase
HLK66_RS15565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HLK66_RS15570	COG0006	proline dipeptidase activity
HLK66_RS15580	COG3872	metal-dependent enzyme
HLK66_RS15590	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLK66_RS15625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLK66_RS15630	COG0095	Lipoate-protein ligase
HLK66_RS15635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLK66_RS15640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLK66_RS15645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLK66_RS15650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HLK66_RS15655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLK66_RS15690	COG4537	Required for transformation and DNA binding
HLK66_RS15695	COG1459	type II secretion system
HLK66_RS15770	COG1705	Flagellar rod assembly protein muramidase FlgJ
HLK66_RS15875	COG4626	Terminase
HLK66_RS15875	COG1802	Transcriptional regulator
HLK66_RS15955	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HLK66_RS15975	COG1484	DNA-dependent DNA replication
HLK66_RS16045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLK66_RS16125	COG1705	Flagellar rod assembly protein muramidase FlgJ
HLK66_RS16310	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HLK66_RS16330	COG1484	DNA-dependent DNA replication
HLK66_RS16405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLK66_RS16430	COG2072	flavoprotein involved in K transport
HLK66_RS16445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLK66_RS16450	COG0011	TIGRFAM Protein of
HLK66_RS16470	COG1940	carbohydrate kinase activity
HLK66_RS16495	COG2318	DinB family
HLK66_RS16510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLK66_RS16515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLK66_RS16545	COG0704	Plays a role in the regulation of phosphate uptake
HLK66_RS16550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLK66_RS16555	COG0581	inorganic phosphate transmembrane transporter activity
HLK66_RS16560	COG0573	inorganic phosphate transmembrane transporter activity
HLK66_RS16565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLK66_RS16580	COG0477	Major facilitator Superfamily
HLK66_RS16590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK66_RS16595	COG2839	Protein conserved in bacteria
HLK66_RS16600	COG5521	maltodextrose utilization protein MalA
HLK66_RS16615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HLK66_RS16625	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HLK66_RS16630	COG0735	belongs to the Fur family
HLK66_RS16640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HLK66_RS16645	COG0513	Belongs to the DEAD box helicase family
HLK66_RS16655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HLK66_RS16660	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLK66_RS16665	COG2384	SAM-dependent methyltransferase
HLK66_RS16675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLK66_RS16685	COG1671	Belongs to the UPF0178 family
HLK66_RS16695	COG0517	IMP dehydrogenase activity
HLK66_RS16700	COG0751	glycine-tRNA ligase activity
HLK66_RS16710	COG1381	Involved in DNA repair and RecF pathway recombination
HLK66_RS16720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLK66_RS16725	COG0295	cytidine deaminase activity
HLK66_RS16730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HLK66_RS16740	COG1480	7TM receptor with intracellular HD hydrolase
HLK66_RS16745	COG1702	phosphate starvation-inducible protein PhoH
HLK66_RS16765	COG4864	UPF0365 protein
HLK66_RS16770	COG1030	water channel activity
HLK66_RS16775	COG1610	YqeY-like protein
HLK66_RS16785	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLK66_RS16800	COG1132	(ABC) transporter
HLK66_RS16805	COG1132	(ABC) transporter
HLK66_RS16810	COG2207	Transcriptional regulator
HLK66_RS16810	COG1917	Cupin 2, conserved barrel domain protein
HLK66_RS16815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HLK66_RS16820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLK66_RS16825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLK66_RS16830	COG2264	protein methyltransferase activity
HLK66_RS16840	COG0443	Heat shock 70 kDa protein
HLK66_RS16845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLK66_RS16850	COG1420	regulation of RNA biosynthetic process
HLK66_RS16855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLK66_RS16860	COG0481	GTPase activity
HLK66_RS16870	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HLK66_RS16875	COG0268	Binds directly to 16S ribosomal RNA
HLK66_RS16880	COG1466	dna polymerase III delta subunit
HLK66_RS16885	COG0658	competence protein
HLK66_RS16885	COG2333	competence protein COMEC
HLK66_RS16890	COG2131	deaminase
HLK66_RS16895	COG1596	polysaccharide export
HLK66_RS16895	COG1555	photosystem II stabilization
HLK66_RS16900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLK66_RS16905	COG2226	methyltransferase
HLK66_RS16910	COG0799	negative regulation of ribosome biogenesis
HLK66_RS16915	COG1713	HD superfamily hydrolase involved in NAD metabolism
HLK66_RS16920	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLK66_RS16925	COG1534	Rna-binding protein
HLK66_RS16935	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HLK66_RS16940	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HLK66_RS16950	COG0688	phosphatidylethanolamine metabolic process
HLK66_RS16955	COG1183	phosphatidylcholine synthase activity
HLK66_RS16970	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK66_RS16990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLK66_RS17035	COG4977	sequence-specific DNA binding
HLK66_RS17050	COG0673	inositol 2-dehydrogenase activity
HLK66_RS17060	COG0789	Transcriptional regulator
HLK66_RS17090	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HLK66_RS17105	COG2801	Transposase and inactivated derivatives
HLK66_RS17120	COG0626	cystathionine gamma-synthase activity
HLK66_RS17125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLK66_RS17130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLK66_RS17135	COG2226	methyltransferase
HLK66_RS17160	COG0768	penicillin binding
HLK66_RS17165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLK66_RS17170	COG0572	uridine kinase
HLK66_RS17185	COG4122	O-methyltransferase activity
HLK66_RS17190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLK66_RS17195	COG3906	Belongs to the UPF0473 family
HLK66_RS17205	COG4472	Bacterial protein of unknown function (DUF965)
HLK66_RS17215	COG0628	permease
HLK66_RS17230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLK66_RS17245	COG1104	cysteine desulfurase activity
HLK66_RS17250	COG1959	2 iron, 2 sulfur cluster binding
HLK66_RS17255	COG2364	Membrane
HLK66_RS17260	COG1473	amidohydrolase
HLK66_RS17270	COG4948	Mandelate Racemase Muconate Lactonizing
HLK66_RS17285	COG3833	ABC-type maltose transport systems, permease component
HLK66_RS17300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLK66_RS17305	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HLK66_RS17310	COG1131	(ABC) transporter
HLK66_RS17315	COG1131	(ABC) transporter
HLK66_RS17320	COG1725	Transcriptional regulator
HLK66_RS17330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLK66_RS17335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HLK66_RS17340	COG0124	histidyl-tRNA synthetase
HLK66_RS17350	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK66_RS17350	COG3103	Sh3 type 3 domain protein
HLK66_RS17350	COG4991	sh3 domain protein
HLK66_RS17360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLK66_RS17365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLK66_RS17370	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HLK66_RS17370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLK66_RS17375	COG5416	Lipopolysaccharide assembly protein A domain
HLK66_RS17380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLK66_RS17380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLK66_RS17390	COG2244	polysaccharide biosynthetic process
HLK66_RS17395	COG2323	membrane
HLK66_RS17405	COG3344	reverse transcriptase
HLK66_RS17410	COG1862	Preprotein translocase
HLK66_RS17420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HLK66_RS17435	COG0632	four-way junction helicase activity
HLK66_RS17465	COG1827	regulation of RNA biosynthetic process
HLK66_RS17470	COG0077	Prephenate dehydratase
HLK66_RS17475	COG4492	Belongs to the UPF0735 family
HLK66_RS17480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLK66_RS17485	COG3290	protein histidine kinase activity
HLK66_RS17490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HLK66_RS17495	COG2868	ribosomal protein
HLK66_RS17500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HLK66_RS17505	COG1530	ribonuclease E activity
HLK66_RS17510	COG1994	Peptidase M50
HLK66_RS17515	COG0739	heme binding
HLK66_RS17520	COG2894	cell division
HLK66_RS17525	COG0850	regulation of cytokinetic process
HLK66_RS17530	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HLK66_RS17535	COG1792	Involved in formation and maintenance of cell shape
HLK66_RS17540	COG1077	Cell shape determining protein MreB Mrl
HLK66_RS17545	COG2003	Belongs to the UPF0758 family
HLK66_RS17550	COG0424	maF-like protein
HLK66_RS17580	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HLK66_RS17600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLK66_RS17640	COG3706	GGDEF domain
HLK66_RS17650	COG0525	valine-tRNA ligase activity
HLK66_RS17655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLK66_RS17660	COG1388	LysM domain
HLK66_RS17660	COG1388	LysM domain
HLK66_RS17665	COG0726	polysaccharide deacetylase
HLK66_RS17665	COG1649	PFAM Uncharacterised BCR, COG1649
HLK66_RS17675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLK66_RS17685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HLK66_RS17690	COG0113	porphobilinogen synthase activity
HLK66_RS17700	COG0181	hydroxymethylbilane synthase activity
HLK66_RS17705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLK66_RS17720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HLK66_RS17725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLK66_RS17730	COG0470	DNA polymerase III
HLK66_RS17730	COG1067	ATP-dependent peptidase activity
HLK66_RS17740	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLK66_RS17750	COG0066	3-isopropylmalate dehydratase activity
HLK66_RS17755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLK66_RS17760	COG0473	3-isopropylmalate dehydrogenase activity
HLK66_RS17765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLK66_RS17770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HLK66_RS17775	COG0440	acetolactate synthase activity
HLK66_RS17780	COG0028	Belongs to the TPP enzyme family
HLK66_RS17790	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HLK66_RS17805	COG0622	Phosphoesterase
HLK66_RS17820	COG5401	PFAM Sporulation and spore germination
HLK66_RS17825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLK66_RS17830	COG1846	Transcriptional regulator
HLK66_RS17835	COG2197	response regulator
HLK66_RS17845	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLK66_RS17850	COG1053	succinate dehydrogenase
HLK66_RS17855	COG2009	succinate dehydrogenase
HLK66_RS17860	COG1719	4-vinyl reductase, 4VR
HLK66_RS17875	COG3118	belongs to the thioredoxin family
HLK66_RS17880	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HLK66_RS17885	COG2086	electron transfer activity
HLK66_RS17890	COG0318	PFAM AMP-dependent synthetase and ligase
HLK66_RS17895	COG3766	membrane
HLK66_RS17905	COG1796	DNA polymerase
HLK66_RS17905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLK66_RS17915	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HLK66_RS17920	COG1940	carbohydrate kinase activity
HLK66_RS17930	COG0395	ABC-type sugar transport system, permease component
HLK66_RS17935	COG1175	transmembrane transport
HLK66_RS17945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLK66_RS17945	COG0072	phenylalanine-tRNA ligase activity
HLK66_RS17950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HLK66_RS17955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLK66_RS17965	COG1070	Carbohydrate kinase
HLK66_RS17970	COG2115	Belongs to the xylose isomerase family
HLK66_RS17975	COG1940	carbohydrate kinase activity
HLK66_RS17980	COG0628	permease
HLK66_RS17985	COG1363	Peptidase, m42
HLK66_RS18000	COG3326	Membrane
HLK66_RS18005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HLK66_RS18015	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HLK66_RS18020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLK66_RS18040	COG1484	DNA-dependent DNA replication
HLK66_RS18045	COG3611	Membrane attachment protein
HLK66_RS18050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLK66_RS18060	COG1971	Probably functions as a manganese efflux pump
HLK66_RS18065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HLK66_RS18070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLK66_RS18070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLK66_RS18075	COG5002	protein histidine kinase activity
HLK66_RS18080	COG0745	RESPONSE REGULATOR receiver
HLK66_RS18085	COG0039	L-malate dehydrogenase activity
HLK66_RS18090	COG0538	isocitrate dehydrogenase activity
HLK66_RS18095	COG0372	Belongs to the citrate synthase family
HLK66_RS18100	COG2707	UPF0756 membrane protein
HLK66_RS18105	COG0628	permease
HLK66_RS18155	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS18170	COG0395	ABC-type sugar transport system, permease component
HLK66_RS18175	COG4209	transmembrane transport
HLK66_RS18180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLK66_RS18185	COG5578	integral membrane protein
HLK66_RS18190	COG0395	ABC-type sugar transport system, permease component
HLK66_RS18195	COG1175	transmembrane transport
HLK66_RS18200	COG1653	transport
HLK66_RS18205	COG2207	Transcriptional regulator
HLK66_RS18210	COG2972	Histidine kinase
HLK66_RS18215	COG3030	protein affecting phage T7 exclusion by the F plasmid
HLK66_RS18230	COG0825	malonyl-CoA metabolic process
HLK66_RS18235	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HLK66_RS18240	COG2186	Transcriptional regulator
HLK66_RS18245	COG0587	DNA-directed DNA polymerase activity
HLK66_RS18260	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLK66_RS18265	COG4109	DRTGG domain
HLK66_RS18275	COG0006	proline dipeptidase activity
HLK66_RS18290	COG0589	response to stress
HLK66_RS18295	COG0165	Argininosuccinate lyase
HLK66_RS18300	COG0137	argininosuccinate synthase activity
HLK66_RS18305	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLK66_RS18310	COG3973	AAA domain
HLK66_RS18325	COG0827	DNA restriction-modification system
HLK66_RS18330	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HLK66_RS18335	COG3874	Sporulation protein YtfJ
HLK66_RS18345	COG1714	RDD family
HLK66_RS18350	COG0616	signal peptide processing
HLK66_RS18355	COG2962	Rard protein
HLK66_RS18360	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HLK66_RS18365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLK66_RS18375	COG0301	tRNA thio-modification
HLK66_RS18380	COG1104	cysteine desulfurase activity
HLK66_RS18385	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HLK66_RS18390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLK66_RS18395	COG1309	transcriptional regulator
HLK66_RS18400	COG1956	GAF domain-containing protein
HLK66_RS18405	COG2199	diguanylate cyclase activity
HLK66_RS18405	COG2203	Gaf domain
HLK66_RS18410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HLK66_RS18435	COG1605	Chorismate mutase
HLK66_RS18435	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HLK66_RS18440	COG0849	cell division
HLK66_RS18445	COG3118	belongs to the thioredoxin family
HLK66_RS18450	COG4980	gas vesicle protein
HLK66_RS18455	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HLK66_RS18460	COG2309	aminopeptidase activity
HLK66_RS18465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLK66_RS18470	COG1674	ftsk spoiiie
HLK66_RS18475	COG4848	Belongs to the UPF0354 family
HLK66_RS18480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_RS18485	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HLK66_RS18500	COG1363	Peptidase, m42
HLK66_RS18505	COG5584	Small secreted protein
HLK66_RS18510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HLK66_RS18520	COG0510	thiamine kinase activity
HLK66_RS18525	COG1523	belongs to the glycosyl hydrolase 13 family
HLK66_RS18535	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HLK66_RS18545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLK66_RS18555	COG1349	DNA-binding transcription factor activity
HLK66_RS18560	COG1187	pseudouridine synthase activity
HLK66_RS18565	COG2244	polysaccharide biosynthetic process
HLK66_RS18570	COG2081	HI0933 family
HLK66_RS18580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLK66_RS18585	COG0495	leucyl-tRNA aminoacylation
HLK66_RS18595	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HLK66_RS18600	COG0154	amidase activity
HLK66_RS18605	COG0406	alpha-ribazole phosphatase activity
HLK66_RS18610	COG2814	Major facilitator Superfamily
HLK66_RS18625	COG1242	4 iron, 4 sulfur cluster binding
HLK66_RS18630	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HLK66_RS18640	COG2267	carboxylic ester hydrolase activity
HLK66_RS18645	COG4990	cell redox homeostasis
HLK66_RS18650	COG0367	asparagine synthase
HLK66_RS18655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLK66_RS18665	COG1506	peptidase
HLK66_RS18670	COG0494	nUDIX hydrolase
HLK66_RS18685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK66_RS18695	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HLK66_RS18700	COG0288	reversible hydration of carbon dioxide
HLK66_RS18720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HLK66_RS18725	COG0596	Alpha beta hydrolase
HLK66_RS18730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HLK66_RS18735	COG1169	isochorismate synthase
HLK66_RS18740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLK66_RS18745	COG0058	SHG alpha-glucan phosphorylase activity
HLK66_RS18750	COG0297	glycogen (starch) synthase activity
HLK66_RS18755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLK66_RS18760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLK66_RS18890	COG1285	pathogenesis
HLK66_RS18910	COG5002	protein histidine kinase activity
HLK66_RS18925	COG0604	alcohol dehydrogenase
HLK66_RS18930	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS18935	COG0778	Nitroreductase
HLK66_RS18945	COG3729	General stress protein
HLK66_RS18965	COG2059	Chromate
HLK66_RS18970	COG2059	Chromate
HLK66_RS18980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLK66_RS18980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLK66_RS18985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLK66_RS18985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLK66_RS18990	COG1309	transcriptional regulator
HLK66_RS18995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLK66_RS19010	COG1979	alcohol dehydrogenase
HLK66_RS19015	COG2155	Conserved Protein
HLK66_RS19020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLK66_RS19025	COG1098	S1 RNA binding domain
HLK66_RS19030	COG0436	Aminotransferase
HLK66_RS19035	COG1522	sequence-specific DNA binding
HLK66_RS19045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK66_RS19050	COG2011	ABC-type metal ion transport system permease component
HLK66_RS19055	COG1464	Belongs to the NlpA lipoprotein family
HLK66_RS19065	COG1914	H( )-stimulated, divalent metal cation uptake system
HLK66_RS19070	COG2032	superoxide dismutase activity
HLK66_RS19080	COG5018	Exonuclease
HLK66_RS19090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLK66_RS19090	COG2111	Na H antiporter
HLK66_RS19095	COG2111	Na H antiporter
HLK66_RS19100	COG1006	Multisubunit Na H antiporter MnhC subunit
HLK66_RS19105	COG0651	ATP synthesis coupled electron transport
HLK66_RS19110	COG1863	multisubunit Na H antiporter MnhE subunit
HLK66_RS19115	COG2212	antiporter activity
HLK66_RS19120	COG1320	monovalent cation:proton antiporter activity
HLK66_RS19140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLK66_RS19170	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS19180	COG3243	poly(R)-hydroxyalkanoic acid synthase
HLK66_RS19185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HLK66_RS19190	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HLK66_RS19195	COG3584	3D domain protein
HLK66_RS19200	COG0492	ferredoxin-NADP+ reductase activity
HLK66_RS19205	COG0316	Belongs to the HesB IscA family
HLK66_RS19215	COG4844	belongs to the
HLK66_RS19225	COG4837	Protein of unknown function (DUF1462)
HLK66_RS19230	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HLK66_RS19235	COG0083	homoserine kinase activity
HLK66_RS19240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLK66_RS19245	COG0460	homoserine dehydrogenase
HLK66_RS19250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLK66_RS19255	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLK66_RS19260	COG0647	UMP catabolic process
HLK66_RS19265	COG2445	Protein of unknown function DUF86
HLK66_RS19270	COG2200	EAL domain
HLK66_RS19270	COG2199	diguanylate cyclase activity
HLK66_RS19270	COG3287	FIST C domain
HLK66_RS19280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLK66_RS19285	COG0739	heme binding
HLK66_RS19290	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HLK66_RS19290	COG2199	diguanylate cyclase activity
HLK66_RS19295	COG3377	Domain of unknown function (DUF1805)
HLK66_RS19300	COG0737	Belongs to the 5'-nucleotidase family
HLK66_RS19305	COG1801	Protein of unknown function DUF72
HLK66_RS19310	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS19315	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HLK66_RS19330	COG1414	Transcriptional regulator
HLK66_RS19335	COG0561	phosphatase activity
HLK66_RS19340	COG0110	maltose O-acetyltransferase activity
HLK66_RS19345	COG0346	lactoylglutathione lyase activity
HLK66_RS19355	COG1940	carbohydrate kinase activity
HLK66_RS19360	COG0719	Fe-S assembly protein
HLK66_RS19365	COG0822	iron-sulfur transferase activity
HLK66_RS19370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLK66_RS19375	COG0719	Fe-S assembly protein
HLK66_RS19380	COG0396	ATPase activity
HLK66_RS19385	COG1464	Belongs to the NlpA lipoprotein family
HLK66_RS19390	COG2011	ABC-type metal ion transport system permease component
HLK66_RS19395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK66_RS19405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_RS19410	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HLK66_RS19415	COG0509	glycine decarboxylation via glycine cleavage system
HLK66_RS19420	COG1393	Belongs to the ArsC family
HLK66_RS19425	COG1960	acyl-CoA dehydrogenase activity
HLK66_RS19445	COG5577	PFAM Coat F domain
HLK66_RS19455	COG0772	Belongs to the SEDS family
HLK66_RS19460	COG0840	transmembrane signaling receptor activity
HLK66_RS19470	COG1126	abc transporter atp-binding protein
HLK66_RS19475	COG0765	amino acid transport
HLK66_RS19480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_RS19490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_RS19495	COG1968	undecaprenyl-diphosphatase activity
HLK66_RS19500	COG0628	permease
HLK66_RS19505	COG1033	growth of symbiont in host cell
HLK66_RS19505	COG2409	Drug exporters of the RND superfamily
HLK66_RS19510	COG1846	Transcriptional regulator
HLK66_RS19515	COG2050	protein possibly involved in aromatic compounds catabolism
HLK66_RS19530	COG0366	Alpha amylase catalytic
HLK66_RS19535	COG1609	Transcriptional regulator
HLK66_RS19540	COG1733	regulation of RNA biosynthetic process
HLK66_RS19545	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HLK66_RS19550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HLK66_RS19560	COG3764	Sortase (surface protein transpeptidase)
HLK66_RS19565	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLK66_RS19575	COG0488	(ABC) transporter
HLK66_RS19585	COG1609	Transcriptional regulator
HLK66_RS19590	COG0673	inositol 2-dehydrogenase activity
HLK66_RS19595	COG1874	Beta-galactosidase
HLK66_RS19600	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HLK66_RS19605	COG0395	ABC-type sugar transport system, permease component
HLK66_RS19610	COG1175	transmembrane transport
HLK66_RS19615	COG1653	transport
HLK66_RS19620	COG2207	Transcriptional regulator
HLK66_RS19620	COG4753	response regulator
HLK66_RS19625	COG2972	Histidine kinase
HLK66_RS19630	COG5578	integral membrane protein
HLK66_RS19640	COG5577	PFAM Coat F domain
HLK66_RS19645	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_RS19660	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_RS19665	COG0710	3-dehydroquinate dehydratase activity
HLK66_RS19675	COG0753	catalase activity
HLK66_RS19685	COG0656	L-ascorbic acid biosynthetic process
HLK66_RS19690	COG0395	ABC-type sugar transport system, permease component
HLK66_RS19695	COG1175	transmembrane transport
HLK66_RS19700	COG1653	transport
HLK66_RS19705	COG1486	melibiose metabolic process
HLK66_RS19710	COG2207	Transcriptional regulator
HLK66_RS19720	COG2217	Heavy metal translocating P-type atpase
HLK66_RS19725	COG2608	mercury ion transmembrane transporter activity
HLK66_RS19735	COG1802	Transcriptional regulator
HLK66_RS19745	COG2814	Major facilitator Superfamily
HLK66_RS19750	COG0789	Transcriptional regulator
HLK66_RS19755	COG2188	Transcriptional regulator
HLK66_RS19760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HLK66_RS19775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS19805	COG0765	amino acid transport
HLK66_RS19810	COG1126	abc transporter atp-binding protein
HLK66_RS19825	COG0395	ABC-type sugar transport system, permease component
HLK66_RS19830	COG1175	transmembrane transport
HLK66_RS19835	COG1653	transport
HLK66_RS19845	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_RS19855	COG1063	alcohol dehydrogenase
HLK66_RS19860	COG3775	system Galactitol-specific IIC component
HLK66_RS19875	COG3711	transcriptional antiterminator
HLK66_RS19875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS19885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HLK66_RS19895	COG1647	Serine aminopeptidase, S33
HLK66_RS19900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLK66_RS19910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HLK66_RS19950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS19960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HLK66_RS19965	COG1660	Displays ATPase and GTPase activities
HLK66_RS19970	COG1051	belongs to the nudix hydrolase family
HLK66_RS19985	COG0492	ferredoxin-NADP+ reductase activity
HLK66_RS19995	COG0457	Tetratricopeptide repeat
HLK66_RS20000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HLK66_RS20000	COG0140	phosphoribosyl-ATP diphosphatase activity
HLK66_RS20005	COG0107	imidazoleglycerol-phosphate synthase activity
HLK66_RS20010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HLK66_RS20015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLK66_RS20020	COG0131	Imidazoleglycerol-phosphate dehydratase
HLK66_RS20025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLK66_RS20030	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HLK66_RS20035	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HLK66_RS20040	COG0110	maltose O-acetyltransferase activity
HLK66_RS20045	COG0546	phosphoglycolate phosphatase activity
HLK66_RS20060	COG1950	PFAM Membrane protein of
HLK66_RS20065	COG3595	metallopeptidase activity
HLK66_RS20070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLK66_RS20075	COG0556	nucleotide-excision repair
HLK66_RS20080	COG4897	Protein conserved in bacteria
HLK66_RS20085	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_RS20100	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_RS20100	COG1454	alcohol dehydrogenase
HLK66_RS20115	COG1595	DNA-templated transcription, initiation
HLK66_RS20125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLK66_RS20135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLK66_RS20140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLK66_RS20145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLK66_RS20150	COG2508	Transcriptional regulator
HLK66_RS20155	COG2233	PERMEase
HLK66_RS20160	COG0281	malic enzyme
HLK66_RS20165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HLK66_RS20185	COG1053	succinate dehydrogenase
HLK66_RS20190	COG2030	dehydratase
HLK66_RS20195	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HLK66_RS20200	COG4988	ABC transporter
HLK66_RS20205	COG1294	oxidase, subunit
HLK66_RS20210	COG1271	oxidase subunit
HLK66_RS20220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLK66_RS20225	COG0205	6-phosphofructokinase activity
HLK66_RS20230	COG0698	ribose 5-phosphate isomerase
HLK66_RS20240	COG1063	alcohol dehydrogenase
HLK66_RS20245	COG3775	system Galactitol-specific IIC component
HLK66_RS20250	COG3414	Phosphotransferase system galactitol-specific IIB component
HLK66_RS20255	COG3414	Phosphotransferase system galactitol-specific IIB component
HLK66_RS20270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLK66_RS20275	COG0205	6-phosphofructokinase activity
HLK66_RS20280	COG0698	ribose 5-phosphate isomerase
HLK66_RS20285	COG0656	L-ascorbic acid biosynthetic process
HLK66_RS20290	COG2814	Major facilitator Superfamily
HLK66_RS20295	COG1733	regulation of RNA biosynthetic process
HLK66_RS20300	COG0793	Belongs to the peptidase S41A family
HLK66_RS20300	COG3409	Peptidoglycan-binding domain 1 protein
HLK66_RS20305	COG3546	catalase activity
HLK66_RS20310	COG2217	Heavy metal translocating P-type atpase
HLK66_RS20315	COG2217	Heavy metal translocating P-type atpase
HLK66_RS20325	COG0739	heme binding
HLK66_RS20330	COG2177	Part of the ABC transporter FtsEX involved in
HLK66_RS20335	COG2884	Cell division ATP-binding protein ftsE
HLK66_RS20340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_RS20360	COG0463	Glycosyl transferase, family 2
HLK66_RS20370	COG0653	protein targeting
HLK66_RS20390	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HLK66_RS20395	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK66_RS20400	COG3842	ATPase activity
HLK66_RS20415	COG1802	Transcriptional regulator
HLK66_RS20420	COG2059	Chromate
HLK66_RS20425	COG2059	Chromate
HLK66_RS20430	COG0405	Gamma-glutamyltransferase
HLK66_RS20445	COG1522	sequence-specific DNA binding
HLK66_RS20455	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLK66_RS20470	COG1516	flagellar protein fliS
HLK66_RS20475	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HLK66_RS20480	COG1334	flagellar protein FlaG
HLK66_RS20500	COG4974	Belongs to the 'phage' integrase family
HLK66_RS20515	COG4974	Belongs to the 'phage' integrase family
HLK66_RS20525	COG0653	protein targeting
HLK66_RS20550	COG4974	Belongs to the 'phage' integrase family
HLK66_RS20565	COG4974	Belongs to the 'phage' integrase family
HLK66_RS20585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HLK66_RS20590	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HLK66_RS20600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLK66_RS20605	COG4786	Flagellar basal body rod
HLK66_RS20605	COG1256	bacterial-type flagellum assembly
HLK66_RS20630	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HLK66_RS20640	COG1307	EDD domain protein, DegV family
HLK66_RS20645	COG2197	response regulator
HLK66_RS20650	COG4585	Histidine kinase
HLK66_RS20655	COG1739	Uncharacterized protein family UPF0029
HLK66_RS20660	COG1316	TRANSCRIPTIONal
HLK66_RS20665	COG2385	sporulation resulting in formation of a cellular spore
HLK66_RS20665	COG2247	cell wall binding repeat
HLK66_RS20685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLK66_RS20690	COG1216	Glycosyl transferase, family 2
HLK66_RS20690	COG1442	glycosyl transferase family 8
HLK66_RS20695	COG1134	teichoic acid transport
HLK66_RS20700	COG1682	transport, permease protein
HLK66_RS20705	COG4193	domain, Protein
HLK66_RS20710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLK66_RS20720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HLK66_RS20725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLK66_RS20735	COG0346	lactoylglutathione lyase activity
HLK66_RS20740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK66_RS20745	COG0366	Alpha amylase catalytic
HLK66_RS20750	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HLK66_RS20765	COG0629	single-stranded DNA binding
HLK66_RS20770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLK66_RS20775	COG4297	protein containing double-stranded beta helix domain
HLK66_RS20780	COG0840	transmembrane signaling receptor activity
HLK66_RS20785	COG2814	Major facilitator Superfamily
HLK66_RS20790	COG1335	isochorismatase
HLK66_RS20815	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_RS20830	COG0604	alcohol dehydrogenase
HLK66_RS20835	COG1660	Displays ATPase and GTPase activities
HLK66_RS20840	COG0371	Dehydrogenase
HLK66_RS20845	COG2084	Dehydrogenase
HLK66_RS20850	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HLK66_RS20855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK66_RS20860	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HLK66_RS20875	COG3339	Conserved Protein
HLK66_RS20880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLK66_RS20895	COG2011	ABC-type metal ion transport system permease component
HLK66_RS20900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK66_RS20910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLK66_RS20915	COG0840	transmembrane signaling receptor activity
HLK66_RS20920	COG0745	RESPONSE REGULATOR receiver
HLK66_RS20925	COG0642	Histidine kinase
HLK66_RS20930	COG1136	(ABC) transporter
HLK66_RS20935	COG0577	efflux transmembrane transporter activity
HLK66_RS20950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HLK66_RS20955	COG4191	Histidine kinase
HLK66_RS20980	COG0300	oxidoreductase activity
HLK66_RS20985	COG0656	L-ascorbic acid biosynthetic process
HLK66_RS20990	COG3976	FMN-binding domain protein
HLK66_RS20990	COG0431	NADPH-dependent FMN reductase
HLK66_RS20990	COG1053	succinate dehydrogenase
HLK66_RS21000	COG0778	Nitroreductase
HLK66_RS21005	COG1115	amino acid carrier protein
HLK66_RS21015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HLK66_RS21025	COG0561	phosphatase activity
HLK66_RS21055	COG1164	Oligoendopeptidase f
HLK66_RS21060	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS21065	COG2188	Transcriptional regulator
HLK66_RS21075	COG5278	phosphoserine phosphatase activity
HLK66_RS21075	COG0840	transmembrane signaling receptor activity
HLK66_RS21090	COG1695	Transcriptional regulator
HLK66_RS21100	COG0191	fructose-bisphosphate aldolase activity
HLK66_RS21105	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HLK66_RS21105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_RS21105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_RS21110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_RS21145	COG2124	cytochrome p450
HLK66_RS21150	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS21155	COG2814	Major facilitator Superfamily
HLK66_RS21160	COG0383	alpha-mannosidase activity
HLK66_RS21180	COG2207	Transcriptional regulator
HLK66_RS21180	COG4753	response regulator
HLK66_RS21185	COG2972	Histidine kinase
HLK66_RS21200	COG0395	ABC-type sugar transport system, permease component
HLK66_RS21205	COG1175	transmembrane transport
HLK66_RS21210	COG2207	Transcriptional regulator
HLK66_RS21215	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS21220	COG0477	Major facilitator Superfamily
HLK66_RS21225	COG1309	transcriptional regulator
HLK66_RS21230	COG0778	Nitroreductase
HLK66_RS21235	COG2207	Transcriptional regulator
HLK66_RS21235	COG4753	response regulator
HLK66_RS21240	COG2972	Histidine kinase
HLK66_RS21255	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HLK66_RS21260	COG0395	ABC-type sugar transport system, permease component
HLK66_RS21265	COG4209	transmembrane transport
HLK66_RS21275	COG2188	Transcriptional regulator
HLK66_RS21280	COG4948	Mandelate Racemase Muconate Lactonizing
HLK66_RS21285	COG1263	PTS System
HLK66_RS21285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS21285	COG2190	(PTS) system
HLK66_RS21295	COG1178	ABC-type Fe3 transport system permease component
HLK66_RS21300	COG3842	ATPase activity
HLK66_RS21305	COG1840	ABC-type Fe3 transport system, periplasmic component
HLK66_RS21310	COG4753	response regulator
HLK66_RS21310	COG2207	Transcriptional regulator
HLK66_RS21320	COG1263	PTS System
HLK66_RS21320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS21340	COG3835	regulator
HLK66_RS21345	COG1929	Belongs to the glycerate kinase type-1 family
HLK66_RS21350	COG2610	gluconate transmembrane transporter activity
HLK66_RS21370	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK66_RS21375	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK66_RS21380	COG3842	ATPase activity
HLK66_RS21385	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HLK66_RS21400	COG2207	Transcriptional regulator
HLK66_RS21400	COG0662	Cupin 2, conserved barrel domain protein
HLK66_RS21410	COG4221	oxidoreductase activity
HLK66_RS21415	COG1595	DNA-templated transcription, initiation
HLK66_RS21435	COG1988	membrane-bound metal-dependent
HLK66_RS21440	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS21445	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS21450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS21450	COG2190	(PTS) system
HLK66_RS21450	COG1263	PTS System
HLK66_RS21460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLK66_RS21465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_RS21470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_RS21475	COG2197	response regulator
HLK66_RS21480	COG2199	diguanylate cyclase activity
HLK66_RS21480	COG2200	EAL domain
HLK66_RS21485	COG3279	Response regulator of the LytR AlgR family
HLK66_RS21495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLK66_RS21540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS21545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLK66_RS21560	COG1316	TRANSCRIPTIONal
HLK66_RS21565	COG2340	Cysteine-rich secretory protein family
HLK66_RS21595	COG2153	protein acetylation
HLK66_RS21610	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_RS21620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_RS21625	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS21630	COG2188	Transcriptional regulator
HLK66_RS21635	COG2368	4-hydroxyphenylacetate
HLK66_RS21665	COG0395	ABC-type sugar transport system, permease component
HLK66_RS21670	COG1175	transmembrane transport
HLK66_RS21680	COG1940	carbohydrate kinase activity
HLK66_RS21685	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLK66_RS21705	COG2720	vancomycin resistance protein
HLK66_RS21710	COG0346	lactoylglutathione lyase activity
HLK66_RS21725	COG1609	Transcriptional regulator
HLK66_RS21740	COG2160	L-arabinose isomerase activity
HLK66_RS21780	COG2079	MmgE PrpD family protein
HLK66_RS21785	COG1473	amidohydrolase
HLK66_RS21790	COG1126	abc transporter atp-binding protein
HLK66_RS21795	COG0765	amino acid transport
HLK66_RS21800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_RS21805	COG0456	acetyltransferase
HLK66_RS21815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_RS21820	COG0436	Aminotransferase
HLK66_RS21825	COG0371	Dehydrogenase
HLK66_RS21840	COG4895	conserved protein (DUF2196)
HLK66_RS21860	COG1846	Transcriptional regulator
HLK66_RS21870	COG2814	Major facilitator Superfamily
HLK66_RS21875	COG0395	ABC-type sugar transport system, permease component
HLK66_RS21880	COG1175	transmembrane transport
HLK66_RS21890	COG0165	Argininosuccinate lyase
HLK66_RS21910	COG0840	transmembrane signaling receptor activity
HLK66_RS21920	COG3344	reverse transcriptase
HLK66_RS21930	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_RS21935	COG2188	Transcriptional regulator
HLK66_RS21940	COG2222	sugar isomerase
HLK66_RS21945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_RS21950	COG1082	Xylose isomerase domain protein TIM barrel
HLK66_RS21955	COG1126	abc transporter atp-binding protein
HLK66_RS21960	COG0765	amino acid transport
HLK66_RS21985	COG0395	ABC-type sugar transport system, permease component
HLK66_RS21990	COG4209	transmembrane transport
HLK66_RS22000	COG3279	Response regulator of the LytR AlgR family
HLK66_RS22005	COG2972	Histidine kinase
HLK66_RS22010	COG0800	Aldolase
HLK66_RS22015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK66_RS22025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK66_RS22030	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS22030	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS22050	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HLK66_RS22090	COG1131	(ABC) transporter
HLK66_RS22095	COG2205	protein histidine kinase activity
HLK66_RS22100	COG0745	RESPONSE REGULATOR receiver
HLK66_RS22105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLK66_RS22115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLK66_RS22120	COG3716	PTS system mannose fructose sorbose family IID component
HLK66_RS22125	COG3715	PTS system
HLK66_RS22135	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS22135	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS22140	COG1846	Transcriptional regulator
HLK66_RS22140	COG1940	carbohydrate kinase activity
HLK66_RS22145	COG3328	transposase activity
HLK66_RS22155	COG4821	SIS domain
HLK66_RS22165	COG1402	creatininase
HLK66_RS22185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS22190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS22200	COG1141	Ferredoxin
HLK66_RS22205	COG0402	S-adenosylhomocysteine deaminase activity
HLK66_RS22210	COG0402	S-adenosylhomocysteine deaminase activity
HLK66_RS22220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLK66_RS22250	COG1522	sequence-specific DNA binding
HLK66_RS22275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS22275	COG1263	PTS System
HLK66_RS22275	COG2190	(PTS) system
HLK66_RS22325	COG1940	carbohydrate kinase activity
HLK66_RS22330	COG2188	Transcriptional regulator
HLK66_RS22340	COG4821	SIS domain
HLK66_RS22370	COG0543	2 iron, 2 sulfur cluster binding
HLK66_RS22375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLK66_RS22385	COG2814	Major facilitator Superfamily
HLK66_RS22400	COG0679	Auxin Efflux Carrier
HLK66_RS22405	COG0281	malic enzyme
HLK66_RS22435	COG0402	S-adenosylhomocysteine deaminase activity
HLK66_RS22445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS22445	COG1263	PTS System
HLK66_RS22445	COG2190	(PTS) system
HLK66_RS22455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLK66_RS22460	COG1609	Transcriptional regulator
HLK66_RS22500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLK66_RS22515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS22550	COG2801	Transposase and inactivated derivatives
HLK66_RS22585	COG1091	dTDP-4-dehydrorhamnose reductase activity
HLK66_RS22620	COG1215	transferase activity, transferring glycosyl groups
HLK66_RS22630	COG0110	maltose O-acetyltransferase activity
HLK66_RS22645	COG4464	protein tyrosine phosphatase activity
HLK66_RS22650	COG0489	protein tyrosine kinase activity
HLK66_RS22655	COG3944	biosynthesis protein
HLK66_RS22665	COG1396	sequence-specific DNA binding
HLK66_RS22675	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HLK66_RS22690	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HLK66_RS22690	COG0662	Cupin 2, conserved barrel domain protein
HLK66_RS22695	COG1132	(ABC) transporter
HLK66_RS22720	COG0438	transferase activity, transferring glycosyl groups
HLK66_RS22730	COG5039	Polysaccharide pyruvyl transferase
HLK66_RS22735	COG1216	Glycosyl transferase, family 2
HLK66_RS22735	COG1442	glycosyl transferase family 8
HLK66_RS22765	COG0438	transferase activity, transferring glycosyl groups
HLK66_RS22775	COG0438	transferase activity, transferring glycosyl groups
HLK66_RS22785	COG0438	transferase activity, transferring glycosyl groups
HLK66_RS22790	COG1215	transferase activity, transferring glycosyl groups
HLK66_RS22795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLK66_RS22800	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HLK66_RS22805	COG0489	protein tyrosine kinase activity
HLK66_RS22810	COG3944	biosynthesis protein
HLK66_RS22815	COG0668	transmembrane transport
HLK66_RS22840	COG2814	Major facilitator Superfamily
HLK66_RS22845	COG4978	Transcriptional regulator
HLK66_RS22845	COG0789	Transcriptional regulator
HLK66_RS22855	COG1846	Transcriptional regulator
HLK66_RS22860	COG1132	(ABC) transporter
HLK66_RS22880	COG3119	arylsulfatase activity
HLK66_RS22885	COG1263	PTS System
HLK66_RS22885	COG2190	(PTS) system
HLK66_RS22885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS22890	COG3711	transcriptional antiterminator
HLK66_RS22895	COG2190	(PTS) system
HLK66_RS22900	COG3711	transcriptional antiterminator
HLK66_RS22900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS22910	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_RS22915	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_RS22920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_RS22940	COG2002	toxin-antitoxin pair type II binding
HLK66_RS22945	COG3706	GGDEF domain
HLK66_RS22950	COG1742	UPF0060 membrane protein
HLK66_RS22970	COG1846	Transcriptional regulator
HLK66_RS22975	COG1566	PFAM secretion protein HlyD family protein
HLK66_RS22980	COG2814	Major facilitator Superfamily
HLK66_RS22990	COG0673	inositol 2-dehydrogenase activity
HLK66_RS23000	COG2814	Major facilitator Superfamily
HLK66_RS23005	COG0596	Alpha beta hydrolase
HLK66_RS23010	COG1309	transcriptional regulator
HLK66_RS23020	COG0667	Aldo Keto reductase
HLK66_RS23025	COG1940	carbohydrate kinase activity
HLK66_RS23030	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS23040	COG3458	cephalosporin-C deacetylase activity
HLK66_RS23045	COG1609	Transcriptional regulator
HLK66_RS23050	COG0701	Predicted permease
HLK66_RS23055	COG0709	Synthesizes selenophosphate from selenide and ATP
HLK66_RS23060	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HLK66_RS23070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLK66_RS23075	COG1388	LysM domain
HLK66_RS23080	COG4191	Histidine kinase
HLK66_RS23085	COG0025	NhaP-type Na H and K H
HLK66_RS23115	COG1408	metallophosphoesterase
HLK66_RS23125	COG2197	response regulator
HLK66_RS23130	COG4585	Histidine kinase
HLK66_RS23135	COG0842	Transport permease protein
HLK66_RS23140	COG1131	(ABC) transporter
HLK66_RS23165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLK66_RS23170	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS23180	COG0697	spore germination
HLK66_RS23185	COG0791	NLP P60 protein
HLK66_RS23185	COG1388	LysM domain
HLK66_RS23190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLK66_RS23195	COG5522	Integral membrane protein (intg_mem_TP0381)
HLK66_RS23205	COG0460	homoserine dehydrogenase
HLK66_RS23220	COG2719	SpoVR family
HLK66_RS23225	COG0768	penicillin binding
HLK66_RS23230	COG3011	Protein conserved in bacteria
HLK66_RS23240	COG1388	LysM domain
HLK66_RS23240	COG0791	NLP P60 protein
HLK66_RS23245	COG4715	Zinc finger, swim domain protein
HLK66_RS23250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLK66_RS23280	COG4786	Flagellar basal body rod
HLK66_RS23285	COG4786	Flagellar basal body rod
HLK66_RS23290	COG1077	Cell shape determining protein MreB Mrl
HLK66_RS23295	COG1609	Transcriptional regulator
HLK66_RS23300	COG0739	heme binding
HLK66_RS23310	COG2385	sporulation resulting in formation of a cellular spore
HLK66_RS23315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLK66_RS23325	COG4836	Membrane
HLK66_RS23330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HLK66_RS23335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HLK66_RS23340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HLK66_RS23350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLK66_RS23355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HLK66_RS23360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLK66_RS23365	COG0356	it plays a direct role in the translocation of protons across the membrane
HLK66_RS23375	COG1404	Belongs to the peptidase S8 family
HLK66_RS23380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HLK66_RS23385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLK66_RS23395	COG0840	transmembrane signaling receptor activity
HLK66_RS23405	COG1971	Probably functions as a manganese efflux pump
HLK66_RS23410	COG0009	L-threonylcarbamoyladenylate synthase
HLK66_RS23420	COG2204	response regulator
HLK66_RS23430	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_RS23435	COG0506	proline dehydrogenase activity
HLK66_RS23440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLK66_RS23445	COG1321	iron dependent repressor
HLK66_RS23445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLK66_RS23450	COG1121	(ABC) transporter
HLK66_RS23455	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLK66_RS23470	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HLK66_RS23475	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_RS23480	COG1253	flavin adenine dinucleotide binding
HLK66_RS23485	COG1253	flavin adenine dinucleotide binding
HLK66_RS23505	COG1435	thymidine kinase activity
HLK66_RS23515	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HLK66_RS23525	COG0191	fructose-bisphosphate aldolase activity
HLK66_RS23530	COG2204	response regulator
HLK66_RS23535	COG4821	SIS domain
HLK66_RS23540	COG0504	CTP synthase activity
HLK66_RS23545	COG3343	RNA polymerase activity
HLK66_RS23555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK66_RS23565	COG3279	Response regulator of the LytR AlgR family
HLK66_RS23570	COG4555	ABC transporter
HLK66_RS23575	COG1668	transmembrane transport
HLK66_RS23585	COG1131	(ABC) transporter
HLK66_RS23610	COG0018	arginyl-trna synthetase
HLK66_RS23615	COG4506	Protein conserved in bacteria
HLK66_RS23620	COG0791	NLP P60 protein
HLK66_RS23620	COG1388	LysM domain
HLK66_RS23620	COG3103	Sh3 type 3 domain protein
HLK66_RS23625	COG0010	Belongs to the arginase family
HLK66_RS23630	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HLK66_RS23635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLK66_RS23645	COG1193	negative regulation of DNA recombination
HLK66_RS23655	COG1994	Peptidase M50
HLK66_RS23660	COG1942	4-Oxalocrotonate Tautomerase
HLK66_RS23665	COG3465	dGTPase activity
HLK66_RS23670	COG1078	dGTPase activity
HLK66_RS23680	COG0477	Major facilitator Superfamily
HLK66_RS23695	COG0280	phosphate acetyltransferase
HLK66_RS23710	COG2363	Small membrane protein
HLK66_RS23725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HLK66_RS23740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLK66_RS23750	COG0314	molybdopterin synthase activity
HLK66_RS23755	COG0351	phosphomethylpyrimidine kinase
HLK66_RS23760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLK66_RS23780	COG0561	phosphatase activity
HLK66_RS23785	COG1271	oxidase subunit
HLK66_RS23790	COG1294	oxidase, subunit
HLK66_RS23795	COG4988	ABC transporter
HLK66_RS23800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HLK66_RS23805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLK66_RS23810	COG2226	methyltransferase
HLK66_RS23815	COG0492	ferredoxin-NADP+ reductase activity
HLK66_RS23820	COG1486	melibiose metabolic process
HLK66_RS23825	COG3610	response to peptide
HLK66_RS23830	COG2966	Psort location CytoplasmicMembrane, score
HLK66_RS23850	COG1131	(ABC) transporter
HLK66_RS23855	COG0686	Belongs to the AlaDH PNT family
HLK66_RS23860	COG2508	Transcriptional regulator
HLK66_RS23860	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HLK66_RS23870	COG1486	melibiose metabolic process
HLK66_RS23875	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_RS23880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_RS23885	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_RS23890	COG2188	Transcriptional regulator
HLK66_RS23900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLK66_RS23905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLK66_RS23915	COG0385	Bile acid
HLK66_RS23920	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_RS23925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_RS23930	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS23940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS23940	COG3711	transcriptional antiterminator
HLK66_RS23950	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLK66_RS24000	COG2508	Transcriptional regulator
HLK66_RS24010	COG0477	Major facilitator Superfamily
HLK66_RS24015	COG0534	Mate efflux family protein
HLK66_RS24025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_RS24035	COG1609	Transcriptional regulator
HLK66_RS24050	COG1609	Transcriptional regulator
HLK66_RS24060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLK66_RS24065	COG1554	hydrolase, family 65, central catalytic
HLK66_RS24075	COG3833	ABC-type maltose transport systems, permease component
HLK66_RS24080	COG1175	transmembrane transport
HLK66_RS24085	COG2182	Extracellular solute-binding protein
HLK66_RS24090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_RS24090	COG1263	PTS System
HLK66_RS24095	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HLK66_RS24100	COG1122	ATPase activity
HLK66_RS24105	COG4721	ABC-type cobalt transport system, permease component
HLK66_RS24110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLK66_RS24120	COG3695	enzyme binding
HLK66_RS24130	COG0411	ABC transporter
HLK66_RS24160	COG0492	ferredoxin-NADP+ reductase activity
HLK66_RS24170	COG4176	ABC-type proline glycine betaine transport system permease component
HLK66_RS24180	COG3507	Belongs to the glycosyl hydrolase 43 family
HLK66_RS24195	COG1073	alpha beta
HLK66_RS24205	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HLK66_RS24210	COG1653	transport
HLK66_RS24220	COG4209	transmembrane transport
HLK66_RS24225	COG0395	ABC-type sugar transport system, permease component
HLK66_RS24230	COG2207	Transcriptional regulator
HLK66_RS24240	COG2721	sulfolactate sulfo-lyase activity
HLK66_RS24245	COG1904	glucuronate isomerase
HLK66_RS24250	COG2755	lipolytic protein G-D-S-L family
HLK66_RS24250	COG0657	acetylesterase activity
HLK66_RS24255	COG2755	lipolytic protein G-D-S-L family
HLK66_RS24270	COG2814	Major facilitator Superfamily
HLK66_RS24300	COG2072	flavoprotein involved in K transport
HLK66_RS24335	COG2208	phosphoserine phosphatase activity
HLK66_RS24340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLK66_RS24345	COG0784	Response regulator, receiver
HLK66_RS24345	COG2198	Histidine kinase
HLK66_RS24345	COG2205	protein histidine kinase activity
HLK66_RS24355	COG4608	Belongs to the ABC transporter superfamily
HLK66_RS24360	COG0444	Belongs to the ABC transporter superfamily
HLK66_RS24365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK66_RS24370	COG0601	transmembrane transport
HLK66_RS24375	COG4166	transmembrane transport
HLK66_RS24385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLK66_RS24390	COG4989	oxidoreductase activity
HLK66_RS24395	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HLK66_RS24400	COG1320	monovalent cation:proton antiporter activity
HLK66_RS24405	COG2212	antiporter activity
HLK66_RS24410	COG1863	multisubunit Na H antiporter MnhE subunit
HLK66_RS24415	COG0651	ATP synthesis coupled electron transport
HLK66_RS24425	COG2111	Na H antiporter
HLK66_RS24440	COG0582	viral genome integration into host DNA
HLK66_RS24445	COG0124	histidyl-tRNA synthetase
HLK66_RS24450	COG3142	Participates in the control of copper homeostasis
HLK66_RS24455	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLK66_RS24460	COG1609	Transcriptional regulator
HLK66_RS24465	COG3459	Glycosyltransferase 36 associated
HLK66_RS24475	COG0395	ABC-type sugar transport system, permease component
HLK66_RS24480	COG1175	transmembrane transport
HLK66_RS24490	COG5039	Polysaccharide pyruvyl transferase
HLK66_RS24495	COG1994	Peptidase M50
HLK66_RS24500	COG1397	ADP-ribosylglycohydrolase
HLK66_RS24525	COG4555	ABC transporter
HLK66_RS24535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK66_RS24540	COG0450	alkyl hydroperoxide reductase
HLK66_RS24545	COG3634	alkyl hydroperoxide reductase activity
HLK66_RS24565	COG4166	transmembrane transport
HLK66_RS24570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_RS24570	COG3711	transcriptional antiterminator
HLK66_RS24575	COG2723	6-phospho-beta-galactosidase activity
HLK66_RS24585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_RS24590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_RS24595	COG3507	Belongs to the glycosyl hydrolase 43 family
HLK66_RS24600	COG0579	oxidoreductase
HLK66_RS24605	COG1464	Belongs to the NlpA lipoprotein family
HLK66_RS24615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK66_RS24620	COG1279	arginine transmembrane transporter activity
HLK66_RS24625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS24635	COG5566	PFAM Mor transcription activator
HLK66_RS24640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLK66_RS24645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLK66_RS24655	COG5002	protein histidine kinase activity
HLK66_RS24675	COG2824	Alkylphosphonate utilization operon protein PhnA
HLK66_RS24685	COG0840	transmembrane signaling receptor activity
HLK66_RS24690	COG1126	abc transporter atp-binding protein
HLK66_RS24695	COG0765	amino acid transport
HLK66_RS24705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK66_RS24710	COG2814	Major facilitator Superfamily
HLK66_RS24720	COG0733	neurotransmitter:sodium symporter activity
HLK66_RS24730	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HLK66_RS24735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLK66_RS24740	COG1696	Membrane protein involved in D-alanine export
HLK66_RS24745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLK66_RS24755	COG0745	RESPONSE REGULATOR receiver
HLK66_RS24760	COG5002	protein histidine kinase activity
HLK66_RS24770	COG0697	spore germination
HLK66_RS24775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS24785	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HLK66_RS24790	COG2169	Transcriptional regulator
HLK66_RS24800	COG1126	abc transporter atp-binding protein
HLK66_RS24805	COG0765	amino acid transport
HLK66_RS24810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_RS24845	COG2223	nitrite transmembrane transporter activity
HLK66_RS24850	COG0109	protoheme IX farnesyltransferase activity
HLK66_RS24855	COG0746	molybdenum cofactor guanylyltransferase activity
HLK66_RS24860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK66_RS24865	COG1763	Mo-molybdopterin cofactor biosynthetic process
HLK66_RS24875	COG0314	molybdopterin synthase activity
HLK66_RS24880	COG0303	'Molybdopterin
HLK66_RS24885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLK66_RS24890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLK66_RS24900	COG2181	nitrate reductase activity
HLK66_RS24905	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HLK66_RS24910	COG1140	nitrate reductase beta subunit
HLK66_RS24915	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HLK66_RS24920	COG4149	molybdate abc transporter
HLK66_RS24925	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLK66_RS24940	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_RS24950	COG0697	spore germination
HLK66_RS24955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_RS25005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLK66_RS25055	COG4974	Belongs to the 'phage' integrase family
HLK66_RS25065	COG1201	RNA secondary structure unwinding
HLK66_RS25095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HLK66_RS25115	COG1074	ATP-dependent DNA helicase activity
HLK66_RS25135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HLK66_RS25145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLK66_RS25150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HLK66_RS25155	COG4853	Protein conserved in bacteria
HLK66_RS25160	COG4863	YycH protein
HLK66_RS25165	COG5002	protein histidine kinase activity
HLK66_RS25170	COG0745	RESPONSE REGULATOR receiver
HLK66_RS25200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLK66_RS25215	COG0305	Participates in initiation and elongation during chromosome replication
HLK66_RS25220	COG0359	binds to the 23S rRNA
HLK66_RS25225	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HLK66_RS25240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HLK66_RS25250	COG0360	Binds together with S18 to 16S ribosomal RNA
HLK66_RS25255	COG0438	transferase activity, transferring glycosyl groups
HLK66_RS25260	COG0012	GTP binding
HLK66_RS25265	COG4481	Protein conserved in bacteria
HLK66_RS25270	COG0668	transmembrane transport
HLK66_RS25280	COG1475	DNA binding
HLK66_RS25285	COG1192	Involved in chromosome partitioning
HLK66_RS25290	COG1475	DNA binding
HLK66_RS25310	COG1847	R3H domain protein
HLK66_RS25320	COG0594	ribonuclease P activity
HLK66_RS25325	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HLK66_RS25355	COG1414	Transcriptional regulator
HLK66_RS25360	COG2814	Major facilitator Superfamily
HLK66_RS25370	COG2329	Antibiotic biosynthesis monooxygenase
HLK66_RS25395	COG0697	spore germination
HLK66_RS25425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLK66_RS25430	COG0640	Transcriptional regulator
HLK66_RS25435	COG0640	Transcriptional regulator
HLK66_RS25445	COG0492	ferredoxin-NADP+ reductase activity
HLK66_RS25455	COG1846	Transcriptional regulator
HLK66_RS25505	COG4712	double-strand break repair protein
HLK66_RS25510	COG0592	DNA-directed DNA polymerase activity
HLK66_RS25695	COG0583	DNA-binding transcription factor activity
HLK66_RS25705	COG2135	peptidase activity
HLK66_RS25750	COG0629	single-stranded DNA binding
HLK66_RS25775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HLK66_RS25815	COG3344	reverse transcriptase
HLK66_RS26055	COG1525	nuclease
HLK66_RS26090	COG3883	PFAM NLP P60 protein
HLK66_RS26090	COG0791	NLP P60 protein
HLK66_RS26155	COG4974	Belongs to the 'phage' integrase family
HLK66_RS26170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLK66_RS26185	COG1793	dna ligase