locus-tag	class	description
BC8716_RS00010	COG5002	protein histidine kinase activity
BC8716_RS00015	COG5002	protein histidine kinase activity
BC8716_RS00050	COG1396	sequence-specific DNA binding
BC8716_RS00065	COG0395	ABC-type sugar transport system, permease component
BC8716_RS00070	COG1175	transmembrane transport
BC8716_RS00090	COG1131	(ABC) transporter
BC8716_RS00120	COG1522	sequence-specific DNA binding
BC8716_RS00125	COG1279	arginine transmembrane transporter activity
BC8716_RS00130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC8716_RS00135	COG2318	DinB family
BC8716_RS00140	COG3011	Protein conserved in bacteria
BC8716_RS00205	COG3546	catalase activity
BC8716_RS00220	COG5577	PFAM Coat F domain
BC8716_RS00230	COG2423	ornithine cyclodeaminase activity
BC8716_RS00235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BC8716_RS00250	COG0010	Belongs to the arginase family
BC8716_RS00265	COG1686	Belongs to the peptidase S11 family
BC8716_RS00270	COG0640	Transcriptional regulator
BC8716_RS00275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BC8716_RS00285	COG2814	Major facilitator Superfamily
BC8716_RS00295	COG1131	(ABC) transporter
BC8716_RS00300	COG2205	protein histidine kinase activity
BC8716_RS00305	COG0745	RESPONSE REGULATOR receiver
BC8716_RS00310	COG3344	reverse transcriptase
BC8716_RS00320	COG3764	Sortase (surface protein transpeptidase)
BC8716_RS00330	COG3397	chitin binding
BC8716_RS00335	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS00345	COG3732	PTS system glucitol sorbitol-specific
BC8716_RS00365	COG0246	Mannitol dehydrogenase
BC8716_RS00370	COG2721	sulfolactate sulfo-lyase activity
BC8716_RS00375	COG0673	inositol 2-dehydrogenase activity
BC8716_RS00380	COG5578	integral membrane protein
BC8716_RS00390	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BC8716_RS00405	COG0395	ABC-type sugar transport system, permease component
BC8716_RS00410	COG4209	transmembrane transport
BC8716_RS00415	COG1653	transport
BC8716_RS00420	COG2207	Transcriptional regulator
BC8716_RS00430	COG3250	beta-galactosidase activity
BC8716_RS00430	COG5297	Belongs to the glycosyl hydrolase family 6
BC8716_RS00440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC8716_RS00455	COG0395	ABC-type sugar transport system, permease component
BC8716_RS00460	COG4209	transmembrane transport
BC8716_RS00465	COG2207	Transcriptional regulator
BC8716_RS00465	COG4753	response regulator
BC8716_RS00470	COG2972	Histidine kinase
BC8716_RS00475	COG1501	Belongs to the glycosyl hydrolase 31 family
BC8716_RS00480	COG3344	reverse transcriptase
BC8716_RS00490	COG1940	carbohydrate kinase activity
BC8716_RS00490	COG1846	Transcriptional regulator
BC8716_RS00495	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BC8716_RS00505	COG0179	Fumarylacetoacetate (FAA) hydrolase
BC8716_RS00510	COG3340	Belongs to the peptidase S51 family
BC8716_RS00520	COG0717	Belongs to the dCTP deaminase family
BC8716_RS00525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BC8716_RS00535	COG0523	cobalamin synthesis protein
BC8716_RS00540	COG3443	Belongs to the bacterial solute-binding protein 9 family
BC8716_RS00545	COG0803	Belongs to the bacterial solute-binding protein 9 family
BC8716_RS00545	COG0803	Belongs to the bacterial solute-binding protein 9 family
BC8716_RS00550	COG1121	(ABC) transporter
BC8716_RS00555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC8716_RS00560	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS00565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC8716_RS00575	COG1414	Transcriptional regulator
BC8716_RS00580	COG0129	dihydroxy-acid dehydratase activity
BC8716_RS00605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC8716_RS00610	COG0716	FMN binding
BC8716_RS00615	COG1597	lipid kinase activity
BC8716_RS00620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BC8716_RS00625	COG0154	amidase activity
BC8716_RS00630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BC8716_RS00635	COG2318	DinB family
BC8716_RS00650	COG1079	Belongs to the binding-protein-dependent transport system permease family
BC8716_RS00655	COG4603	Belongs to the binding-protein-dependent transport system permease family
BC8716_RS00660	COG3845	ABC transporter
BC8716_RS00665	COG1744	ABC transporter substrate-binding protein PnrA-like
BC8716_RS00670	COG4851	CamS sex pheromone cAM373 precursor
BC8716_RS00675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BC8716_RS00680	COG0210	DNA helicase
BC8716_RS00685	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BC8716_RS00690	COG1120	ATPase activity
BC8716_RS00695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC8716_RS00700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC8716_RS00720	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BC8716_RS00725	COG4496	protein, YerC YecD
BC8716_RS00730	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BC8716_RS00735	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BC8716_RS00755	COG1510	regulation of RNA biosynthetic process
BC8716_RS00825	COG1131	(ABC) transporter
BC8716_RS00830	COG2197	response regulator
BC8716_RS00835	COG4585	Histidine kinase
BC8716_RS00855	COG0151	Belongs to the GarS family
BC8716_RS00860	COG0138	bifunctional purine biosynthesis protein purh
BC8716_RS00865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BC8716_RS00870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BC8716_RS00875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BC8716_RS00880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BC8716_RS00885	COG0047	phosphoribosylformylglycinamidine synthase activity
BC8716_RS00890	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BC8716_RS00895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BC8716_RS00900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BC8716_RS00905	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BC8716_RS00910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BC8716_RS00950	COG3654	unkown
BC8716_RS00975	COG4565	transcriptional regulatory protein
BC8716_RS00980	COG3290	protein histidine kinase activity
BC8716_RS00985	COG0025	NhaP-type Na H and K H
BC8716_RS01000	COG1191	sigma factor activity
BC8716_RS01010	COG3328	transposase activity
BC8716_RS01035	COG1132	(ABC) transporter
BC8716_RS01040	COG1132	(ABC) transporter
BC8716_RS01055	COG1755	Isoprenylcysteine carboxyl methyltransferase
BC8716_RS01060	COG3424	synthase
BC8716_RS01065	COG0789	Transcriptional regulator
BC8716_RS01070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC8716_RS01075	COG1904	glucuronate isomerase
BC8716_RS01080	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BC8716_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS01090	COG1349	DNA-binding transcription factor activity
BC8716_RS01095	COG2059	Chromate
BC8716_RS01100	COG2059	Chromate
BC8716_RS01105	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BC8716_RS01110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BC8716_RS01125	COG3764	Sortase (surface protein transpeptidase)
BC8716_RS01145	COG1510	regulation of RNA biosynthetic process
BC8716_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS01155	COG1454	alcohol dehydrogenase
BC8716_RS01160	COG2186	Transcriptional regulator
BC8716_RS01165	COG1556	Lactate utilization protein
BC8716_RS01170	COG1139	Iron-sulfur cluster binding protein
BC8716_RS01175	COG0247	lactate metabolic process
BC8716_RS01180	COG1620	l-lactate permease
BC8716_RS01190	COG2124	cytochrome p450
BC8716_RS01195	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BC8716_RS01200	COG0326	Molecular chaperone. Has ATPase activity
BC8716_RS01205	COG1335	isochorismatase
BC8716_RS01215	COG1476	TRANSCRIPTIONal
BC8716_RS01220	COG0737	Belongs to the 5'-nucleotidase family
BC8716_RS01225	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS01230	COG3290	protein histidine kinase activity
BC8716_RS01230	COG3829	transcription factor binding
BC8716_RS01240	COG1408	metallophosphoesterase
BC8716_RS01260	COG2252	PERMEase
BC8716_RS01285	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BC8716_RS01295	COG2376	Dihydroxyacetone kinase
BC8716_RS01305	COG1846	Transcriptional regulator
BC8716_RS01315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BC8716_RS01325	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BC8716_RS01330	COG0577	efflux transmembrane transporter activity
BC8716_RS01335	COG1136	(ABC) transporter
BC8716_RS01365	COG1595	DNA-templated transcription, initiation
BC8716_RS01405	COG0791	NLP P60 protein
BC8716_RS01405	COG0741	lytic transglycosylase activity
BC8716_RS01415	COG3226	Transcriptional regulator
BC8716_RS01420	COG0596	Alpha beta hydrolase
BC8716_RS01435	COG3226	Transcriptional regulator
BC8716_RS01485	COG3226	Transcriptional regulator
BC8716_RS01510	COG0577	efflux transmembrane transporter activity
BC8716_RS01515	COG1136	(ABC) transporter
BC8716_RS01525	COG5002	protein histidine kinase activity
BC8716_RS01545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BC8716_RS01545	COG0519	Catalyzes the synthesis of GMP from XMP
BC8716_RS01550	COG1305	Transglutaminase-like
BC8716_RS01555	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BC8716_RS01560	COG0714	Associated with various cellular activities
BC8716_RS01570	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BC8716_RS01590	COG0768	penicillin binding
BC8716_RS01600	COG0778	Nitroreductase
BC8716_RS01610	COG4824	toxin secretion phage lysis holin
BC8716_RS01650	COG0281	malic enzyme
BC8716_RS01655	COG3493	citrate carrier protein
BC8716_RS01660	COG4565	transcriptional regulatory protein
BC8716_RS01665	COG3290	protein histidine kinase activity
BC8716_RS01670	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BC8716_RS01675	COG1126	abc transporter atp-binding protein
BC8716_RS01680	COG0765	amino acid transport
BC8716_RS01685	COG0765	amino acid transport
BC8716_RS01705	COG0463	Glycosyl transferase, family 2
BC8716_RS01715	COG4485	Bacterial membrane protein, YfhO
BC8716_RS01730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BC8716_RS01735	COG2427	Protein of unknown function (DUF1641)
BC8716_RS01740	COG3383	formate dehydrogenase (NAD+) activity
BC8716_RS01745	COG2116	formate transmembrane transporter activity
BC8716_RS01750	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BC8716_RS01755	COG0314	molybdopterin synthase activity
BC8716_RS01760	COG1763	Mo-molybdopterin cofactor biosynthetic process
BC8716_RS01765	COG0303	'Molybdopterin
BC8716_RS01770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BC8716_RS01780	COG0746	molybdenum cofactor guanylyltransferase activity
BC8716_RS01785	COG0315	cyclic pyranopterin monophosphate synthase activity
BC8716_RS01790	COG2368	4-hydroxyphenylacetate
BC8716_RS01795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BC8716_RS01800	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BC8716_RS01805	COG4821	SIS domain
BC8716_RS01830	COG0459	protein refolding
BC8716_RS01835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BC8716_RS01840	COG1266	CAAX protease self-immunity
BC8716_RS01850	COG0371	Dehydrogenase
BC8716_RS01855	COG1464	Belongs to the NlpA lipoprotein family
BC8716_RS01860	COG2011	ABC-type metal ion transport system permease component
BC8716_RS01865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC8716_RS01870	COG0805	protein transport
BC8716_RS01875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BC8716_RS01880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BC8716_RS01885	COG0488	(ABC) transporter
BC8716_RS01890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BC8716_RS01895	COG0456	acetyltransferase
BC8716_RS01900	COG1214	PFAM Peptidase M22, glycoprotease
BC8716_RS01905	COG0802	atpase or kinase
BC8716_RS01910	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BC8716_RS01920	COG0626	cystathionine gamma-synthase activity
BC8716_RS01925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC8716_RS01930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC8716_RS01935	COG1285	pathogenesis
BC8716_RS01945	COG1396	sequence-specific DNA binding
BC8716_RS02025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS02025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS02025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS02035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS02035	COG3711	transcriptional antiterminator
BC8716_RS02045	COG0384	phenazine biosynthesis protein PhzF
BC8716_RS02060	COG0702	epimerase
BC8716_RS02075	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BC8716_RS02080	COG1687	branched-chain amino acid
BC8716_RS02085	COG5646	InterPro IPR014922
BC8716_RS02115	COG0473	3-isopropylmalate dehydrogenase activity
BC8716_RS02120	COG1802	Transcriptional regulator
BC8716_RS02125	COG2514	catechol 2,3-dioxygenase activity
BC8716_RS02130	COG2140	Oxalate decarboxylase
BC8716_RS02140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC8716_RS02145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BC8716_RS02150	COG0640	Transcriptional regulator
BC8716_RS02155	COG0346	lactoylglutathione lyase activity
BC8716_RS02160	COG0640	Transcriptional regulator
BC8716_RS02165	COG1329	Transcriptional regulator
BC8716_RS02170	COG1278	Cold shock
BC8716_RS02210	COG0662	Cupin 2, conserved barrel domain protein
BC8716_RS02215	COG2226	methyltransferase
BC8716_RS02220	COG4282	regulation of fungal-type cell wall biogenesis
BC8716_RS02260	COG3091	SprT-like family
BC8716_RS02270	COG2183	response to ionizing radiation
BC8716_RS02280	COG1191	sigma factor activity
BC8716_RS02285	COG2172	sigma factor antagonist activity
BC8716_RS02290	COG1366	Belongs to the anti-sigma-factor antagonist family
BC8716_RS02295	COG2208	phosphoserine phosphatase activity
BC8716_RS02300	COG2172	sigma factor antagonist activity
BC8716_RS02305	COG1366	Belongs to the anti-sigma-factor antagonist family
BC8716_RS02310	COG1366	Belongs to the anti-sigma-factor antagonist family
BC8716_RS02315	COG2337	Toxic component of a toxin-antitoxin (TA) module
BC8716_RS02320	COG0864	Transcriptional regulator
BC8716_RS02325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BC8716_RS02330	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BC8716_RS02335	COG0736	holo-[acyl-carrier-protein] synthase activity
BC8716_RS02340	COG0705	Rhomboid family
BC8716_RS02350	COG1368	sulfuric ester hydrolase activity
BC8716_RS02355	COG1876	peptidase activity
BC8716_RS02365	COG5578	integral membrane protein
BC8716_RS02370	COG3214	Protein conserved in bacteria
BC8716_RS02380	COG0673	inositol 2-dehydrogenase activity
BC8716_RS02385	COG1082	Xylose isomerase domain protein TIM barrel
BC8716_RS02395	COG1320	monovalent cation:proton antiporter activity
BC8716_RS02400	COG2212	antiporter activity
BC8716_RS02405	COG1863	multisubunit Na H antiporter MnhE subunit
BC8716_RS02410	COG0651	ATP synthesis coupled electron transport
BC8716_RS02415	COG1006	Multisubunit Na H antiporter MnhC subunit
BC8716_RS02420	COG2111	Na H antiporter
BC8716_RS02425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BC8716_RS02425	COG2111	Na H antiporter
BC8716_RS02430	COG2205	protein histidine kinase activity
BC8716_RS02440	COG1733	regulation of RNA biosynthetic process
BC8716_RS02445	COG4608	Belongs to the ABC transporter superfamily
BC8716_RS02450	COG0791	NLP P60 protein
BC8716_RS02455	COG1619	proteins homologs of microcin C7 resistance protein MccF
BC8716_RS02460	COG4166	transmembrane transport
BC8716_RS02465	COG0444	Belongs to the ABC transporter superfamily
BC8716_RS02470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC8716_RS02475	COG0601	transmembrane transport
BC8716_RS02480	COG2362	D-Aminopeptidase
BC8716_RS02485	COG4191	Histidine kinase
BC8716_RS02490	COG0784	Response regulator, receiver
BC8716_RS02495	COG0765	amino acid transport
BC8716_RS02500	COG0765	amino acid transport
BC8716_RS02505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC8716_RS02515	COG2962	Rard protein
BC8716_RS02520	COG2706	6-phosphogluconolactonase activity
BC8716_RS02525	COG0686	Belongs to the AlaDH PNT family
BC8716_RS02530	COG2508	Transcriptional regulator
BC8716_RS02530	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BC8716_RS02540	COG0531	amino acid
BC8716_RS02545	COG1876	peptidase activity
BC8716_RS02560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BC8716_RS02565	COG0596	Alpha beta hydrolase
BC8716_RS02570	COG0861	Integral membrane protein TerC family
BC8716_RS02580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BC8716_RS02585	COG2818	Glycosylase
BC8716_RS02600	COG1404	Belongs to the peptidase S8 family
BC8716_RS02605	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BC8716_RS02615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BC8716_RS02630	COG3835	regulator
BC8716_RS02635	COG1929	Belongs to the glycerate kinase type-1 family
BC8716_RS02650	COG0024	Methionine aminopeptidase
BC8716_RS02655	COG0456	acetyltransferase
BC8716_RS02660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC8716_RS02675	COG1846	Transcriptional regulator
BC8716_RS02680	COG2239	Acts as a magnesium transporter
BC8716_RS02685	COG2197	response regulator
BC8716_RS02690	COG4585	Histidine kinase
BC8716_RS02695	COG3239	Fatty acid desaturase
BC8716_RS02700	COG2207	Transcriptional regulator
BC8716_RS02705	COG1486	melibiose metabolic process
BC8716_RS02710	COG0586	Pfam SNARE associated Golgi protein
BC8716_RS02715	COG1191	sigma factor activity
BC8716_RS02725	COG0395	ABC-type sugar transport system, permease component
BC8716_RS02730	COG4209	transmembrane transport
BC8716_RS02735	COG2207	Transcriptional regulator
BC8716_RS02735	COG4753	response regulator
BC8716_RS02740	COG2972	Histidine kinase
BC8716_RS02755	COG2223	nitrite transmembrane transporter activity
BC8716_RS02765	COG2197	response regulator
BC8716_RS02780	COG2181	nitrate reductase activity
BC8716_RS02790	COG1140	nitrate reductase beta subunit
BC8716_RS02795	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BC8716_RS02805	COG2195	Cleaves the N-terminal amino acid of tripeptides
BC8716_RS02810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS02810	COG1263	PTS System
BC8716_RS02810	COG2190	(PTS) system
BC8716_RS02815	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BC8716_RS02820	COG1737	Transcriptional regulator
BC8716_RS02895	COG1511	domain protein
BC8716_RS02900	COG1674	ftsk spoiiie
BC8716_RS02905	COG4499	WXG100 protein secretion system (Wss), protein YukC
BC8716_RS02915	COG4842	Belongs to the WXG100 family
BC8716_RS02920	COG0395	ABC-type sugar transport system, permease component
BC8716_RS02925	COG1175	transmembrane transport
BC8716_RS02940	COG1119	ATPase activity
BC8716_RS02945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC8716_RS02950	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS02965	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BC8716_RS02970	COG3457	Alanine racemase
BC8716_RS02975	COG0626	cystathionine gamma-synthase activity
BC8716_RS02980	COG1735	metal-dependent hydrolase with the TIM-barrel fold
BC8716_RS03010	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BC8716_RS03015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC8716_RS03020	COG0159	tryptophan synthase activity
BC8716_RS03050	COG2610	gluconate transmembrane transporter activity
BC8716_RS03055	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BC8716_RS03060	COG3395	kinase activity
BC8716_RS03065	COG1349	DNA-binding transcription factor activity
BC8716_RS03070	COG0697	spore germination
BC8716_RS03095	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BC8716_RS03100	COG3844	kynureninase activity
BC8716_RS03105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BC8716_RS03110	COG2271	Major facilitator Superfamily
BC8716_RS03115	COG5294	Protein conserved in bacteria
BC8716_RS03130	COG2188	Transcriptional regulator
BC8716_RS03135	COG3394	polysaccharide catabolic process
BC8716_RS03140	COG1486	melibiose metabolic process
BC8716_RS03145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BC8716_RS03150	COG1447	Phosphotransferase system cellobiose-specific component IIA
BC8716_RS03155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BC8716_RS03160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BC8716_RS03170	COG0798	PFAM Bile acid sodium symporter
BC8716_RS03185	COG0163	prenyltransferase activity
BC8716_RS03190	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS03195	COG1312	Catalyzes the dehydration of D-mannonate
BC8716_RS03200	COG1063	alcohol dehydrogenase
BC8716_RS03205	COG1053	succinate dehydrogenase
BC8716_RS03210	COG0473	3-isopropylmalate dehydrogenase activity
BC8716_RS03215	COG0583	DNA-binding transcription factor activity
BC8716_RS03240	COG2188	Transcriptional regulator
BC8716_RS03245	COG1131	(ABC) transporter
BC8716_RS03255	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BC8716_RS03260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BC8716_RS03275	COG1587	Uroporphyrinogen-III synthase
BC8716_RS03275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BC8716_RS03280	COG0529	Catalyzes the synthesis of activated sulfate
BC8716_RS03285	COG0306	phosphate transporter
BC8716_RS03290	COG2046	Belongs to the sulfate adenylyltransferase family
BC8716_RS03295	COG0175	sulfate reduction
BC8716_RS03310	COG1116	anion transmembrane transporter activity
BC8716_RS03315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC8716_RS03320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC8716_RS03325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BC8716_RS03330	COG0431	NADPH-dependent FMN reductase
BC8716_RS03335	COG5583	Uncharacterized small protein (DUF2292)
BC8716_RS03345	COG2258	MOSC domain
BC8716_RS03370	COG0318	PFAM AMP-dependent synthetase and ligase
BC8716_RS03385	COG1942	4-Oxalocrotonate Tautomerase
BC8716_RS03390	COG0477	Major facilitator Superfamily
BC8716_RS03400	COG4126	flavin adenine dinucleotide binding
BC8716_RS03425	COG2508	Transcriptional regulator
BC8716_RS03430	COG0673	inositol 2-dehydrogenase activity
BC8716_RS03440	COG1940	carbohydrate kinase activity
BC8716_RS03450	COG1070	Carbohydrate kinase
BC8716_RS03455	COG2115	Belongs to the xylose isomerase family
BC8716_RS03460	COG1414	Transcriptional regulator
BC8716_RS03465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC8716_RS03475	COG4608	Belongs to the ABC transporter superfamily
BC8716_RS03480	COG0444	Belongs to the ABC transporter superfamily
BC8716_RS03485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC8716_RS03495	COG0747	negative chemotaxis
BC8716_RS03500	COG1228	amidohydrolase
BC8716_RS03505	COG1228	amidohydrolase
BC8716_RS03530	COG1653	transport
BC8716_RS03535	COG0395	ABC-type sugar transport system, permease component
BC8716_RS03540	COG4209	transmembrane transport
BC8716_RS03550	COG3507	Belongs to the glycosyl hydrolase 43 family
BC8716_RS03555	COG0662	Cupin 2, conserved barrel domain protein
BC8716_RS03555	COG2207	Transcriptional regulator
BC8716_RS03560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC8716_RS03565	COG2011	ABC-type metal ion transport system permease component
BC8716_RS03570	COG1464	Belongs to the NlpA lipoprotein family
BC8716_RS03575	COG1473	amidohydrolase
BC8716_RS03585	COG2084	Dehydrogenase
BC8716_RS03595	COG1737	Transcriptional regulator
BC8716_RS03600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BC8716_RS03605	COG2186	Transcriptional regulator
BC8716_RS03610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BC8716_RS03620	COG4145	pantothenate transmembrane transporter activity
BC8716_RS03660	COG0710	3-dehydroquinate dehydratase activity
BC8716_RS03670	COG0655	NAD(P)H dehydrogenase (quinone) activity
BC8716_RS03680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC8716_RS03695	COG0745	RESPONSE REGULATOR receiver
BC8716_RS03700	COG2205	protein histidine kinase activity
BC8716_RS03720	COG2610	gluconate transmembrane transporter activity
BC8716_RS03725	COG4948	Mandelate Racemase Muconate Lactonizing
BC8716_RS03730	COG0800	Aldolase
BC8716_RS03735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC8716_RS03745	COG2755	lipolytic protein G-D-S-L family
BC8716_RS03750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BC8716_RS03765	COG1215	transferase activity, transferring glycosyl groups
BC8716_RS03780	COG0438	transferase activity, transferring glycosyl groups
BC8716_RS03795	COG0438	transferase activity, transferring glycosyl groups
BC8716_RS03825	COG2226	methyltransferase
BC8716_RS03835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BC8716_RS03840	COG0535	radical SAM domain protein
BC8716_RS03845	COG0471	metal ion transport
BC8716_RS03850	COG1929	Belongs to the glycerate kinase type-1 family
BC8716_RS03855	COG3212	peptidase
BC8716_RS03860	COG3212	peptidase
BC8716_RS03865	COG3850	Histidine kinase
BC8716_RS03865	COG5002	protein histidine kinase activity
BC8716_RS03870	COG0745	RESPONSE REGULATOR receiver
BC8716_RS03875	COG4821	SIS domain
BC8716_RS03880	COG2188	Transcriptional regulator
BC8716_RS03890	COG3584	3D domain protein
BC8716_RS03890	COG1388	LysM domain
BC8716_RS03895	COG3344	reverse transcriptase
BC8716_RS03900	COG1940	carbohydrate kinase activity
BC8716_RS03905	COG1653	transport
BC8716_RS03910	COG0395	ABC-type sugar transport system, permease component
BC8716_RS03915	COG4209	transmembrane transport
BC8716_RS03920	COG4753	response regulator
BC8716_RS03920	COG2207	Transcriptional regulator
BC8716_RS03925	COG2972	Histidine kinase
BC8716_RS03930	COG5578	integral membrane protein
BC8716_RS03940	COG0383	alpha-mannosidase activity
BC8716_RS03955	COG2723	6-phospho-beta-galactosidase activity
BC8716_RS03970	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS03975	COG1309	transcriptional regulator
BC8716_RS03980	COG3711	transcriptional antiterminator
BC8716_RS03980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS03985	COG2723	6-phospho-beta-galactosidase activity
BC8716_RS03990	COG1447	Phosphotransferase system cellobiose-specific component IIA
BC8716_RS03995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BC8716_RS04000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BC8716_RS04005	COG1357	PFAM Pentapeptide repeats (8 copies)
BC8716_RS04025	COG2807	transmembrane transport
BC8716_RS04035	COG2186	Transcriptional regulator
BC8716_RS04040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC8716_RS04045	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS04065	COG1312	Catalyzes the dehydration of D-mannonate
BC8716_RS04110	COG0840	transmembrane signaling receptor activity
BC8716_RS04115	COG2851	Citrate transporter
BC8716_RS04130	COG3290	protein histidine kinase activity
BC8716_RS04130	COG3829	transcription factor binding
BC8716_RS04135	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BC8716_RS04140	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BC8716_RS04145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC8716_RS04155	COG1917	Cupin 2, conserved barrel domain protein
BC8716_RS04160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS04160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS04165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS04170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS04170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS04170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS04175	COG0191	fructose-bisphosphate aldolase activity
BC8716_RS04180	COG3711	transcriptional antiterminator
BC8716_RS04185	COG0246	Mannitol dehydrogenase
BC8716_RS04190	COG2721	sulfolactate sulfo-lyase activity
BC8716_RS04195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BC8716_RS04205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BC8716_RS04210	COG1063	alcohol dehydrogenase
BC8716_RS04220	COG1653	transport
BC8716_RS04225	COG1175	transmembrane transport
BC8716_RS04240	COG2873	o-acetylhomoserine
BC8716_RS04245	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC8716_RS04250	COG0673	inositol 2-dehydrogenase activity
BC8716_RS04255	COG0191	fructose-bisphosphate aldolase activity
BC8716_RS04260	COG1082	Xylose isomerase domain protein TIM barrel
BC8716_RS04265	COG0673	inositol 2-dehydrogenase activity
BC8716_RS04270	COG1082	Xylose isomerase domain protein TIM barrel
BC8716_RS04275	COG3962	Belongs to the TPP enzyme family
BC8716_RS04280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC8716_RS04285	COG3718	enzyme involved in inositol metabolism
BC8716_RS04290	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS04295	COG1349	DNA-binding transcription factor activity
BC8716_RS04300	COG2814	Major facilitator Superfamily
BC8716_RS04305	COG1309	transcriptional regulator
BC8716_RS04310	COG2076	Multidrug Resistance protein
BC8716_RS04315	COG2076	Multidrug Resistance protein
BC8716_RS04320	COG3279	Response regulator of the LytR AlgR family
BC8716_RS04340	COG1131	(ABC) transporter
BC8716_RS04345	COG1486	melibiose metabolic process
BC8716_RS04350	COG4214	carbohydrate transport
BC8716_RS04355	COG1129	ABC transporter
BC8716_RS04360	COG4213	ABC transporter substrate-binding protein
BC8716_RS04365	COG2160	L-arabinose isomerase activity
BC8716_RS04370	COG1069	ribulokinase activity
BC8716_RS04380	COG0371	Dehydrogenase
BC8716_RS04385	COG0647	UMP catabolic process
BC8716_RS04390	COG2207	Transcriptional regulator
BC8716_RS04400	COG5578	integral membrane protein
BC8716_RS04405	COG0395	ABC-type sugar transport system, permease component
BC8716_RS04410	COG1175	transmembrane transport
BC8716_RS04425	COG0395	ABC-type sugar transport system, permease component
BC8716_RS04430	COG1175	transmembrane transport
BC8716_RS04440	COG3401	FG-GAP repeat protein
BC8716_RS04455	COG0745	RESPONSE REGULATOR receiver
BC8716_RS04460	COG5002	protein histidine kinase activity
BC8716_RS04470	COG0395	ABC-type sugar transport system, permease component
BC8716_RS04475	COG1175	transmembrane transport
BC8716_RS04480	COG1653	transport
BC8716_RS04485	COG2207	Transcriptional regulator
BC8716_RS04485	COG4753	response regulator
BC8716_RS04490	COG2972	Histidine kinase
BC8716_RS04510	COG0673	inositol 2-dehydrogenase activity
BC8716_RS04515	COG1917	Cupin 2, conserved barrel domain protein
BC8716_RS04515	COG4977	sequence-specific DNA binding
BC8716_RS04520	COG2814	Major facilitator Superfamily
BC8716_RS04525	COG3254	rhamnose metabolic process
BC8716_RS04530	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS04530	COG3347	Dehydrogenase
BC8716_RS04535	COG4806	L-rhamnose isomerase
BC8716_RS04535	COG1070	Carbohydrate kinase
BC8716_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS04575	COG0726	polysaccharide deacetylase
BC8716_RS04580	COG0673	inositol 2-dehydrogenase activity
BC8716_RS04590	COG0584	glycerophosphoryl diester phosphodiesterase
BC8716_RS04595	COG0395	ABC-type sugar transport system, permease component
BC8716_RS04600	COG4209	transmembrane transport
BC8716_RS04605	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BC8716_RS04625	COG0584	glycerophosphoryl diester phosphodiesterase
BC8716_RS04630	COG1653	transport
BC8716_RS04635	COG0395	ABC-type sugar transport system, permease component
BC8716_RS04640	COG1175	transmembrane transport
BC8716_RS04645	COG3842	ATPase activity
BC8716_RS04650	COG0584	glycerophosphoryl diester phosphodiesterase
BC8716_RS04655	COG1017	nitric oxide dioxygenase activity
BC8716_RS04655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BC8716_RS04660	COG1959	2 iron, 2 sulfur cluster binding
BC8716_RS04675	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS04680	COG0183	Belongs to the thiolase family
BC8716_RS04685	COG0318	PFAM AMP-dependent synthetase and ligase
BC8716_RS04690	COG0318	PFAM AMP-dependent synthetase and ligase
BC8716_RS04705	COG2226	methyltransferase
BC8716_RS04710	COG0515	serine threonine protein kinase
BC8716_RS04720	COG3842	ATPase activity
BC8716_RS04725	COG0395	ABC-type sugar transport system, permease component
BC8716_RS04730	COG1175	transmembrane transport
BC8716_RS04745	COG1917	Cupin 2, conserved barrel domain protein
BC8716_RS04750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BC8716_RS04755	COG0456	acetyltransferase
BC8716_RS04765	COG0697	spore germination
BC8716_RS04770	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS04775	COG1454	alcohol dehydrogenase
BC8716_RS04780	COG2066	Belongs to the glutaminase family
BC8716_RS04785	COG2610	gluconate transmembrane transporter activity
BC8716_RS04795	COG3290	protein histidine kinase activity
BC8716_RS04795	COG3829	transcription factor binding
BC8716_RS04820	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
BC8716_RS04840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BC8716_RS04845	COG0395	ABC-type sugar transport system, permease component
BC8716_RS04850	COG1175	transmembrane transport
BC8716_RS04855	COG1940	carbohydrate kinase activity
BC8716_RS04860	COG2723	6-phospho-beta-galactosidase activity
BC8716_RS04865	COG1609	Transcriptional regulator
BC8716_RS04875	COG1263	PTS System
BC8716_RS04875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS04880	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BC8716_RS04900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BC8716_RS04905	COG1737	Transcriptional regulator
BC8716_RS04910	COG1132	(ABC) transporter
BC8716_RS04915	COG0789	Transcriptional regulator
BC8716_RS04920	COG1609	Transcriptional regulator
BC8716_RS04950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BC8716_RS04950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BC8716_RS04955	COG0628	permease
BC8716_RS04960	COG1528	Iron-storage protein
BC8716_RS04975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BC8716_RS04980	COG2267	carboxylic ester hydrolase activity
BC8716_RS04985	COG0569	domain protein
BC8716_RS04990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BC8716_RS04995	COG2358	TRAP transporter, solute receptor (TAXI family
BC8716_RS05015	COG1051	belongs to the nudix hydrolase family
BC8716_RS05035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC8716_RS05040	COG0697	spore germination
BC8716_RS05050	COG0180	Tryptophanyl-tRNA synthetase
BC8716_RS05055	COG2226	methyltransferase
BC8716_RS05070	COG2072	flavoprotein involved in K transport
BC8716_RS05105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BC8716_RS05130	COG0577	efflux transmembrane transporter activity
BC8716_RS05130	COG1136	(ABC) transporter
BC8716_RS05140	COG2814	Major facilitator Superfamily
BC8716_RS05145	COG1309	transcriptional regulator
BC8716_RS05155	COG0745	RESPONSE REGULATOR receiver
BC8716_RS05160	COG0577	efflux transmembrane transporter activity
BC8716_RS05165	COG1136	(ABC) transporter
BC8716_RS05170	COG1819	glycosyl
BC8716_RS05175	COG1396	sequence-specific DNA binding
BC8716_RS05185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC8716_RS05195	COG2207	Transcriptional regulator
BC8716_RS05195	COG1917	Cupin 2, conserved barrel domain protein
BC8716_RS05200	COG2723	6-phospho-beta-galactosidase activity
BC8716_RS05205	COG2190	(PTS) system
BC8716_RS05215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS05215	COG1263	PTS System
BC8716_RS05215	COG2190	(PTS) system
BC8716_RS05220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BC8716_RS05230	COG3959	Transketolase, thiamine diphosphate binding domain
BC8716_RS05240	COG1609	Transcriptional regulator
BC8716_RS05245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BC8716_RS05255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC8716_RS05265	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BC8716_RS05270	COG5662	AntiSigma factor
BC8716_RS05275	COG1595	DNA-templated transcription, initiation
BC8716_RS05325	COG0747	negative chemotaxis
BC8716_RS05330	COG2755	lipolytic protein G-D-S-L family
BC8716_RS05335	COG1063	alcohol dehydrogenase
BC8716_RS05370	COG2211	Major facilitator Superfamily
BC8716_RS05375	COG3829	transcription factor binding
BC8716_RS05375	COG3290	protein histidine kinase activity
BC8716_RS05380	COG4948	Mandelate Racemase Muconate Lactonizing
BC8716_RS05390	COG0789	Transcriptional regulator
BC8716_RS05410	COG0789	Transcriptional regulator
BC8716_RS05450	COG0726	polysaccharide deacetylase
BC8716_RS05465	COG1737	Transcriptional regulator
BC8716_RS05480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BC8716_RS05490	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BC8716_RS05495	COG1447	Phosphotransferase system cellobiose-specific component IIA
BC8716_RS05515	COG0489	protein tyrosine kinase activity
BC8716_RS05520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS05520	COG2190	(PTS) system
BC8716_RS05520	COG1263	PTS System
BC8716_RS05525	COG3711	transcriptional antiterminator
BC8716_RS05530	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC8716_RS05555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BC8716_RS05560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BC8716_RS05565	COG0101	tRNA pseudouridine synthase activity
BC8716_RS05570	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BC8716_RS05575	COG1122	ATPase activity
BC8716_RS05580	COG1122	ATPase activity
BC8716_RS05585	COG0203	ribosomal protein L17
BC8716_RS05590	COG0202	RNA polymerase activity
BC8716_RS05595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BC8716_RS05600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BC8716_RS05605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BC8716_RS05610	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BC8716_RS05615	COG0024	Methionine aminopeptidase
BC8716_RS05620	COG0563	adenylate kinase activity
BC8716_RS05625	COG0201	protein transport
BC8716_RS05630	COG0200	Binds to the 23S rRNA
BC8716_RS05635	COG1841	ribosomal large subunit assembly
BC8716_RS05640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BC8716_RS05645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BC8716_RS05650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BC8716_RS05655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BC8716_RS05660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BC8716_RS05665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BC8716_RS05670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BC8716_RS05675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BC8716_RS05680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BC8716_RS05685	COG0255	Belongs to the universal ribosomal protein uL29 family
BC8716_RS05690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BC8716_RS05695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BC8716_RS05700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BC8716_RS05705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BC8716_RS05710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BC8716_RS05715	COG0089	rRNA binding
BC8716_RS05720	COG0088	Forms part of the polypeptide exit tunnel
BC8716_RS05725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BC8716_RS05730	COG0051	transcription antitermination factor activity, RNA binding
BC8716_RS05735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BC8716_RS05740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BC8716_RS05745	COG0049	tRNA binding
BC8716_RS05750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BC8716_RS05755	COG1358	cellular component organization or biogenesis
BC8716_RS05760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BC8716_RS05765	COG0085	RNA polymerase activity
BC8716_RS05770	COG2813	Specifically methylates the guanine in position
BC8716_RS05775	COG0222	ribosome binding
BC8716_RS05780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BC8716_RS05785	COG0081	regulation of translation
BC8716_RS05790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BC8716_RS05795	COG0250	Participates in transcription elongation, termination and antitermination
BC8716_RS05800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BC8716_RS05815	COG3688	RNA-binding protein containing a PIN domain
BC8716_RS05820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC8716_RS05830	COG0215	cysteine-tRNA ligase activity
BC8716_RS05835	COG1045	serine acetyltransferase
BC8716_RS05840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BC8716_RS05845	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BC8716_RS05850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BC8716_RS05855	COG4956	integral membrane protein (PIN domain superfamily)
BC8716_RS05860	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BC8716_RS05865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BC8716_RS05870	COG0542	response to heat
BC8716_RS05875	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BC8716_RS05880	COG3880	PFAM UvrB UvrC protein
BC8716_RS05965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BC8716_RS05970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BC8716_RS05975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BC8716_RS05980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BC8716_RS05985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BC8716_RS05990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BC8716_RS05995	COG0512	Glutamine amidotransferase of anthranilate synthase
BC8716_RS06000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BC8716_RS06005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC8716_RS06010	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BC8716_RS06015	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BC8716_RS06020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BC8716_RS06025	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BC8716_RS06030	COG0037	tRNA processing
BC8716_RS06035	COG0515	serine threonine protein kinase
BC8716_RS06040	COG2304	oxidoreductase activity
BC8716_RS06045	COG2208	phosphoserine phosphatase activity
BC8716_RS06050	COG2851	Citrate transporter
BC8716_RS06060	COG1098	S1 RNA binding domain
BC8716_RS06085	COG0492	ferredoxin-NADP+ reductase activity
BC8716_RS06090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC8716_RS06095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC8716_RS06100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BC8716_RS06105	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BC8716_RS06110	COG3956	TIGRFAM MazG family protein
BC8716_RS06115	COG2244	polysaccharide biosynthetic process
BC8716_RS06125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BC8716_RS06135	COG2002	toxin-antitoxin pair type II binding
BC8716_RS06140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BC8716_RS06150	COG0193	aminoacyl-tRNA hydrolase activity
BC8716_RS06155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BC8716_RS06160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BC8716_RS06165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BC8716_RS06170	COG2088	sporulation resulting in formation of a cellular spore
BC8716_RS06175	COG0251	oxidation-reduction process
BC8716_RS06180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC8716_RS06185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BC8716_RS06195	COG4466	Protein conserved in bacteria
BC8716_RS06205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BC8716_RS06210	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BC8716_RS06215	COG3583	domain protein
BC8716_RS06215	COG3584	3D domain protein
BC8716_RS06220	COG0084	hydrolase, TatD family'
BC8716_RS06235	COG0488	(ABC) transporter
BC8716_RS06250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC8716_RS06250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC8716_RS06265	COG2002	toxin-antitoxin pair type II binding
BC8716_RS06270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BC8716_RS06275	COG2827	Endonuclease containing a URI domain
BC8716_RS06280	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BC8716_RS06285	COG4467	Involved in initiation control of chromosome replication
BC8716_RS06290	COG1774	PSP1 C-terminal conserved region
BC8716_RS06295	COG0470	DNA polymerase III
BC8716_RS06300	COG3870	Protein conserved in bacteria
BC8716_RS06305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BC8716_RS06310	COG1982	Orn Lys Arg decarboxylase major
BC8716_RS06320	COG1078	dGTPase activity
BC8716_RS06325	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS06335	COG2204	response regulator
BC8716_RS06340	COG4191	Histidine kinase
BC8716_RS06375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BC8716_RS06380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BC8716_RS06385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BC8716_RS06395	COG0740	serine-type endopeptidase activity
BC8716_RS06405	COG0590	tRNA wobble adenosine to inosine editing
BC8716_RS06420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC8716_RS06425	COG0601	transmembrane transport
BC8716_RS06430	COG0444	Belongs to the ABC transporter superfamily
BC8716_RS06435	COG4608	Belongs to the ABC transporter superfamily
BC8716_RS06445	COG0765	amino acid transport
BC8716_RS06450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC8716_RS06460	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS06480	COG0006	proline dipeptidase activity
BC8716_RS06490	COG1757	Na H antiporter
BC8716_RS06495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BC8716_RS06500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BC8716_RS06505	COG3829	transcription factor binding
BC8716_RS06510	COG2508	Transcriptional regulator
BC8716_RS06515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC8716_RS06520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BC8716_RS06530	COG0516	GMP reductase activity
BC8716_RS06530	COG0517	IMP dehydrogenase activity
BC8716_RS06560	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS06565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BC8716_RS06570	COG0187	DNA topoisomerase II activity
BC8716_RS06580	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BC8716_RS06585	COG2501	S4 domain
BC8716_RS06590	COG0592	DNA-directed DNA polymerase activity
BC8716_RS06595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BC8716_RS06600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BC8716_RS06605	COG0594	ribonuclease P activity
BC8716_RS06610	COG0706	membrane insertase activity
BC8716_RS06615	COG1847	R3H domain protein
BC8716_RS06620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BC8716_RS06625	COG0445	tRNA wobble uridine modification
BC8716_RS06630	COG0357	Ribosomal RNA small subunit methyltransferase G
BC8716_RS06635	COG1475	DNA binding
BC8716_RS06640	COG1192	Involved in chromosome partitioning
BC8716_RS06645	COG1475	DNA binding
BC8716_RS06650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BC8716_RS06660	COG3949	Membrane
BC8716_RS06665	COG4481	Protein conserved in bacteria
BC8716_RS06670	COG0012	GTP binding
BC8716_RS06675	COG0360	Binds together with S18 to 16S ribosomal RNA
BC8716_RS06680	COG0629	single-stranded DNA binding
BC8716_RS06685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BC8716_RS06695	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BC8716_RS06700	COG0359	binds to the 23S rRNA
BC8716_RS06705	COG0305	Participates in initiation and elongation during chromosome replication
BC8716_RS06710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BC8716_RS06740	COG0745	RESPONSE REGULATOR receiver
BC8716_RS06745	COG5002	protein histidine kinase activity
BC8716_RS06755	COG4853	Protein conserved in bacteria
BC8716_RS06760	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BC8716_RS06765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC8716_RS06775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BC8716_RS06780	COG0210	DNA helicase
BC8716_RS06790	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BC8716_RS06825	COG1063	alcohol dehydrogenase
BC8716_RS06835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BC8716_RS06840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BC8716_RS06840	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BC8716_RS06845	COG0235	Class ii aldolase
BC8716_RS06855	COG1131	(ABC) transporter
BC8716_RS06875	COG0601	transmembrane transport
BC8716_RS06885	COG0444	Belongs to the ABC transporter superfamily
BC8716_RS06890	COG4608	Belongs to the ABC transporter superfamily
BC8716_RS06910	COG3275	phosphorelay sensor kinase activity
BC8716_RS06920	COG1966	Carbon starvation protein
BC8716_RS06945	COG1595	DNA-templated transcription, initiation
BC8716_RS06960	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BC8716_RS06965	COG1802	Transcriptional regulator
BC8716_RS06970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BC8716_RS06985	COG0372	Belongs to the citrate synthase family
BC8716_RS06990	COG0583	DNA-binding transcription factor activity
BC8716_RS07005	COG2186	Transcriptional regulator
BC8716_RS07015	COG0277	FAD linked oxidase domain protein
BC8716_RS07020	COG0247	lactate metabolic process
BC8716_RS07025	COG0579	oxidoreductase
BC8716_RS07030	COG2508	Transcriptional regulator
BC8716_RS07035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BC8716_RS07040	COG0402	S-adenosylhomocysteine deaminase activity
BC8716_RS07050	COG2182	Extracellular solute-binding protein
BC8716_RS07055	COG1175	transmembrane transport
BC8716_RS07060	COG3833	ABC-type maltose transport systems, permease component
BC8716_RS07065	COG1609	Transcriptional regulator
BC8716_RS07070	COG2031	fatty acid transporter
BC8716_RS07075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BC8716_RS07080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BC8716_RS07090	COG0346	lactoylglutathione lyase activity
BC8716_RS07105	COG0813	purine-nucleoside phosphorylase activity
BC8716_RS07110	COG0523	cobalamin synthesis protein
BC8716_RS07115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BC8716_RS07120	COG1193	negative regulation of DNA recombination
BC8716_RS07125	COG1307	EDD domain protein, DegV family
BC8716_RS07155	COG2807	transmembrane transport
BC8716_RS07165	COG0745	RESPONSE REGULATOR receiver
BC8716_RS07185	COG2154	pterin-4-alpha-carbinolamine dehydratase
BC8716_RS07190	COG0733	neurotransmitter:sodium symporter activity
BC8716_RS07225	COG1114	Component of the transport system for branched-chain amino acids
BC8716_RS07240	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BC8716_RS07245	COG3290	protein histidine kinase activity
BC8716_RS07250	COG4565	transcriptional regulatory protein
BC8716_RS07255	COG0471	metal ion transport
BC8716_RS07270	COG1733	regulation of RNA biosynthetic process
BC8716_RS07275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC8716_RS07285	COG1116	anion transmembrane transporter activity
BC8716_RS07290	COG1137	ATPase activity
BC8716_RS07305	COG2972	Histidine kinase
BC8716_RS07305	COG0745	RESPONSE REGULATOR receiver
BC8716_RS07315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BC8716_RS07315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BC8716_RS07345	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
BC8716_RS07355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BC8716_RS07360	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BC8716_RS07365	COG5504	Zn-dependent protease
BC8716_RS07370	COG0789	Transcriptional regulator
BC8716_RS07375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BC8716_RS07380	COG1733	regulation of RNA biosynthetic process
BC8716_RS07385	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BC8716_RS07390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BC8716_RS07395	COG1597	lipid kinase activity
BC8716_RS07400	COG2323	membrane
BC8716_RS07405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BC8716_RS07410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BC8716_RS07415	COG1132	(ABC) transporter
BC8716_RS07420	COG0753	catalase activity
BC8716_RS07430	COG2814	Major facilitator Superfamily
BC8716_RS07435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BC8716_RS07440	COG0840	transmembrane signaling receptor activity
BC8716_RS07450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC8716_RS07455	COG0561	phosphatase activity
BC8716_RS07460	COG0803	Belongs to the bacterial solute-binding protein 9 family
BC8716_RS07465	COG1121	(ABC) transporter
BC8716_RS07470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC8716_RS07470	COG1321	iron dependent repressor
BC8716_RS07475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC8716_RS07490	COG2814	Major facilitator Superfamily
BC8716_RS07495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BC8716_RS07500	COG0551	DNA topoisomerase type I activity
BC8716_RS07500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC8716_RS07505	COG1785	Belongs to the alkaline phosphatase family
BC8716_RS07510	COG0024	Methionine aminopeptidase
BC8716_RS07515	COG2268	Band 7 protein
BC8716_RS07530	COG0723	plastoquinol--plastocyanin reductase activity
BC8716_RS07530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC8716_RS07535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BC8716_RS07540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC8716_RS07545	COG0513	Belongs to the DEAD box helicase family
BC8716_RS07580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC8716_RS07595	COG2986	histidine ammonia-lyase
BC8716_RS07600	COG0351	phosphomethylpyrimidine kinase
BC8716_RS07605	COG3314	Sporulation integral membrane protein YlbJ
BC8716_RS07610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BC8716_RS07620	COG0004	ammonium transporteR
BC8716_RS07640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC8716_RS07645	COG0456	acetyltransferase
BC8716_RS07650	COG2363	Small membrane protein
BC8716_RS07660	COG3773	Cell wall hydrolase
BC8716_RS07670	COG1725	Transcriptional regulator
BC8716_RS07675	COG1131	(ABC) transporter
BC8716_RS07680	COG4152	abc transporter atp-binding protein
BC8716_RS07685	COG1668	transmembrane transport
BC8716_RS07695	COG0706	membrane insertase activity
BC8716_RS07700	COG3253	May function as heme-dependent peroxidase
BC8716_RS07705	COG1024	Enoyl-CoA hydratase
BC8716_RS07710	COG0280	phosphate acetyltransferase
BC8716_RS07715	COG0095	Lipoate-protein ligase
BC8716_RS07720	COG1301	dicarboxylic acid transport
BC8716_RS07725	COG1078	dGTPase activity
BC8716_RS07730	COG3465	dGTPase activity
BC8716_RS07740	COG5577	PFAM Coat F domain
BC8716_RS07750	COG3764	Sortase (surface protein transpeptidase)
BC8716_RS07765	COG1164	Oligoendopeptidase f
BC8716_RS07775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC8716_RS07780	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BC8716_RS07785	COG0010	Belongs to the arginase family
BC8716_RS07795	COG0018	arginyl-trna synthetase
BC8716_RS07800	COG2839	Protein conserved in bacteria
BC8716_RS07805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC8716_RS07810	COG2181	nitrate reductase activity
BC8716_RS07810	COG0247	lactate metabolic process
BC8716_RS07815	COG0183	Belongs to the thiolase family
BC8716_RS07820	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC8716_RS07825	COG1960	acyl-CoA dehydrogenase activity
BC8716_RS07835	COG3343	RNA polymerase activity
BC8716_RS07840	COG0504	CTP synthase activity
BC8716_RS07855	COG0191	fructose-bisphosphate aldolase activity
BC8716_RS07860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BC8716_RS07865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BC8716_RS07870	COG1494	fructose-1,6-bisphosphatase
BC8716_RS07875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BC8716_RS07880	COG0254	rRNA binding
BC8716_RS07885	COG1435	thymidine kinase activity
BC8716_RS07895	COG0446	pyridine nucleotide-disulphide oxidoreductase
BC8716_RS07900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BC8716_RS07920	COG0009	L-threonylcarbamoyladenylate synthase
BC8716_RS07930	COG1971	Probably functions as a manganese efflux pump
BC8716_RS07940	COG5278	phosphoserine phosphatase activity
BC8716_RS07940	COG0840	transmembrane signaling receptor activity
BC8716_RS07945	COG0698	ribose 5-phosphate isomerase
BC8716_RS07950	COG4475	Protein of unknown function (DUF436)
BC8716_RS07955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BC8716_RS07960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BC8716_RS07965	COG0456	acetyltransferase
BC8716_RS07970	COG1404	Belongs to the peptidase S8 family
BC8716_RS07985	COG0356	it plays a direct role in the translocation of protons across the membrane
BC8716_RS07990	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC8716_RS07995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BC8716_RS08000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC8716_RS08005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BC8716_RS08010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BC8716_RS08015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BC8716_RS08020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BC8716_RS08035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BC8716_RS08040	COG2385	sporulation resulting in formation of a cellular spore
BC8716_RS08045	COG0739	heme binding
BC8716_RS08050	COG2076	Multidrug Resistance protein
BC8716_RS08055	COG2076	Multidrug Resistance protein
BC8716_RS08060	COG1609	Transcriptional regulator
BC8716_RS08065	COG1077	Cell shape determining protein MreB Mrl
BC8716_RS08070	COG4786	Flagellar basal body rod
BC8716_RS08075	COG4786	Flagellar basal body rod
BC8716_RS08100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BC8716_RS08110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BC8716_RS08125	COG2318	DinB family
BC8716_RS08135	COG0791	NLP P60 protein
BC8716_RS08135	COG1388	LysM domain
BC8716_RS08140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BC8716_RS08150	COG2388	GCN5-related N-acetyl-transferase
BC8716_RS08155	COG1316	TRANSCRIPTIONal
BC8716_RS08165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BC8716_RS08170	COG0772	Belongs to the SEDS family
BC8716_RS08175	COG2814	Major facilitator Superfamily
BC8716_RS08180	COG0537	adenosine 5'-monophosphoramidase activity
BC8716_RS08185	COG0590	tRNA wobble adenosine to inosine editing
BC8716_RS08200	COG1280	lysine exporter protein (LysE YggA)
BC8716_RS08210	COG1316	TRANSCRIPTIONal
BC8716_RS08215	COG3944	biosynthesis protein
BC8716_RS08220	COG0489	protein tyrosine kinase activity
BC8716_RS08225	COG4464	protein tyrosine phosphatase activity
BC8716_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS08265	COG2910	NAD(P)H-binding
BC8716_RS08275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BC8716_RS08300	COG0493	'glutamate synthase
BC8716_RS08305	COG1349	DNA-binding transcription factor activity
BC8716_RS08315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS08315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS08315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS08320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS08335	COG2376	Dihydroxyacetone kinase
BC8716_RS08345	COG0149	triose-phosphate isomerase activity
BC8716_RS08365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC8716_RS08370	COG3708	Transcriptional regulator
BC8716_RS08370	COG2207	Transcriptional regulator
BC8716_RS08375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BC8716_RS08385	COG0395	ABC-type sugar transport system, permease component
BC8716_RS08390	COG1175	transmembrane transport
BC8716_RS08400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BC8716_RS08405	COG1984	allophanate hydrolase subunit 2
BC8716_RS08410	COG1914	H( )-stimulated, divalent metal cation uptake system
BC8716_RS08415	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BC8716_RS08440	COG0778	Nitroreductase
BC8716_RS08445	COG1609	Transcriptional regulator
BC8716_RS08450	COG1621	beta-fructofuranosidase activity
BC8716_RS08455	COG1263	PTS System
BC8716_RS08455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS08465	COG0300	oxidoreductase activity
BC8716_RS08485	COG1959	2 iron, 2 sulfur cluster binding
BC8716_RS08490	COG0537	adenosine 5'-monophosphoramidase activity
BC8716_RS08505	COG1116	anion transmembrane transporter activity
BC8716_RS08510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC8716_RS08525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC8716_RS08535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BC8716_RS08540	COG2068	MobA-Related Protein
BC8716_RS08550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BC8716_RS08555	COG2080	2 iron, 2 sulfur cluster binding
BC8716_RS08560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BC8716_RS08565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC8716_RS08570	COG2508	Transcriptional regulator
BC8716_RS08580	COG3648	Uricase
BC8716_RS08580	COG3195	allantoin biosynthetic process
BC8716_RS08590	COG1288	antiporter activity
BC8716_RS08595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BC8716_RS08600	COG0154	amidase activity
BC8716_RS08605	COG3361	conserved protein (COG2071)
BC8716_RS08660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS08675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BC8716_RS08680	COG1116	anion transmembrane transporter activity
BC8716_RS08685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC8716_RS08700	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BC8716_RS08705	COG5658	integral membrane protein
BC8716_RS08710	COG0640	Transcriptional regulator
BC8716_RS08715	COG0583	DNA-binding transcription factor activity
BC8716_RS08720	COG4122	O-methyltransferase activity
BC8716_RS08725	COG1115	amino acid carrier protein
BC8716_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS08785	COG0697	spore germination
BC8716_RS08790	COG0814	amino acid
BC8716_RS08815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BC8716_RS08820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BC8716_RS08830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BC8716_RS08845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BC8716_RS08860	COG0463	Glycosyl transferase, family 2
BC8716_RS08860	COG1216	Glycosyl transferase, family 2
BC8716_RS08865	COG2244	polysaccharide biosynthetic process
BC8716_RS08870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BC8716_RS08890	COG2207	Transcriptional regulator
BC8716_RS08900	COG4221	oxidoreductase activity
BC8716_RS08905	COG2249	NAD(P)H dehydrogenase (quinone) activity
BC8716_RS08910	COG1733	regulation of RNA biosynthetic process
BC8716_RS08975	COG1486	melibiose metabolic process
BC8716_RS08990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BC8716_RS08990	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BC8716_RS08995	COG1447	Phosphotransferase system cellobiose-specific component IIA
BC8716_RS09005	COG2971	BadF BadG BcrA BcrD
BC8716_RS09015	COG0583	DNA-binding transcription factor activity
BC8716_RS09025	COG0747	negative chemotaxis
BC8716_RS09030	COG0601	transmembrane transport
BC8716_RS09035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC8716_RS09040	COG0444	Belongs to the ABC transporter superfamily
BC8716_RS09045	COG4608	Belongs to the ABC transporter superfamily
BC8716_RS09050	COG1473	amidohydrolase
BC8716_RS09055	COG0471	metal ion transport
BC8716_RS09065	COG1473	amidohydrolase
BC8716_RS09080	COG1840	ABC-type Fe3 transport system, periplasmic component
BC8716_RS09085	COG3842	ATPase activity
BC8716_RS09095	COG2972	Histidine kinase
BC8716_RS09100	COG2207	Transcriptional regulator
BC8716_RS09100	COG4753	response regulator
BC8716_RS09110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BC8716_RS09115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC8716_RS09125	COG3409	Peptidoglycan-binding domain 1 protein
BC8716_RS09135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC8716_RS09140	COG1464	Belongs to the NlpA lipoprotein family
BC8716_RS09145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC8716_RS09150	COG2011	ABC-type metal ion transport system permease component
BC8716_RS09155	COG1464	Belongs to the NlpA lipoprotein family
BC8716_RS09160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC8716_RS09165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC8716_RS09170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC8716_RS09180	COG0765	amino acid transport
BC8716_RS09185	COG1126	abc transporter atp-binding protein
BC8716_RS09190	COG0456	acetyltransferase
BC8716_RS09195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BC8716_RS09205	COG1473	amidohydrolase
BC8716_RS09210	COG0431	NADPH-dependent FMN reductase
BC8716_RS09220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC8716_RS09225	COG4172	Belongs to the ABC transporter superfamily
BC8716_RS09230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC8716_RS09240	COG0747	negative chemotaxis
BC8716_RS09245	COG0583	DNA-binding transcription factor activity
BC8716_RS09260	COG1741	Belongs to the pirin family
BC8716_RS09265	COG1733	regulation of RNA biosynthetic process
BC8716_RS09270	COG0402	S-adenosylhomocysteine deaminase activity
BC8716_RS09285	COG3546	catalase activity
BC8716_RS09305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BC8716_RS09310	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BC8716_RS09315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BC8716_RS09315	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BC8716_RS09320	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS09330	COG0318	PFAM AMP-dependent synthetase and ligase
BC8716_RS09345	COG2814	Major facilitator Superfamily
BC8716_RS09350	COG1063	alcohol dehydrogenase
BC8716_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS09360	COG1349	DNA-binding transcription factor activity
BC8716_RS09365	COG0698	ribose 5-phosphate isomerase
BC8716_RS09370	COG2376	Dihydroxyacetone kinase
BC8716_RS09375	COG2376	Dihydroxyacetone kinase
BC8716_RS09380	COG1494	fructose-1,6-bisphosphatase
BC8716_RS09385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC8716_RS09405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC8716_RS09410	COG1609	Transcriptional regulator
BC8716_RS09435	COG1175	transmembrane transport
BC8716_RS09440	COG0395	ABC-type sugar transport system, permease component
BC8716_RS09450	COG2972	Histidine kinase
BC8716_RS09455	COG2207	Transcriptional regulator
BC8716_RS09455	COG4753	response regulator
BC8716_RS09480	COG4682	membrane
BC8716_RS09545	COG2207	Transcriptional regulator
BC8716_RS09545	COG4753	response regulator
BC8716_RS09550	COG2972	Histidine kinase
BC8716_RS09555	COG1653	transport
BC8716_RS09560	COG1175	transmembrane transport
BC8716_RS09565	COG0395	ABC-type sugar transport system, permease component
BC8716_RS09570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BC8716_RS09585	COG1263	PTS System
BC8716_RS09585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS09590	COG1737	Transcriptional regulator
BC8716_RS09615	COG0456	acetyltransferase
BC8716_RS09625	COG1349	DNA-binding transcription factor activity
BC8716_RS09635	COG3414	Phosphotransferase system galactitol-specific IIB component
BC8716_RS09640	COG3775	system Galactitol-specific IIC component
BC8716_RS09645	COG1063	alcohol dehydrogenase
BC8716_RS09655	COG2315	Protein conserved in bacteria
BC8716_RS09660	COG1469	GTP cyclohydrolase I activity
BC8716_RS09670	COG3655	Transcriptional regulator
BC8716_RS09675	COG3739	integral membrane protein
BC8716_RS09695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BC8716_RS09710	COG2190	(PTS) system
BC8716_RS09710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS09710	COG1263	PTS System
BC8716_RS09720	COG2972	Histidine kinase
BC8716_RS09720	COG0745	RESPONSE REGULATOR receiver
BC8716_RS09725	COG3279	Response regulator of the LytR AlgR family
BC8716_RS09740	COG1396	sequence-specific DNA binding
BC8716_RS09750	COG0747	negative chemotaxis
BC8716_RS09755	COG0601	transmembrane transport
BC8716_RS09760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC8716_RS09765	COG0444	Belongs to the ABC transporter superfamily
BC8716_RS09770	COG4608	Belongs to the ABC transporter superfamily
BC8716_RS09775	COG2195	Cleaves the N-terminal amino acid of tripeptides
BC8716_RS09785	COG1132	(ABC) transporter
BC8716_RS09815	COG1131	(ABC) transporter
BC8716_RS09830	COG0745	RESPONSE REGULATOR receiver
BC8716_RS09835	COG5002	protein histidine kinase activity
BC8716_RS09885	COG1609	Transcriptional regulator
BC8716_RS09890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC8716_RS09895	COG1869	D-ribose catabolic process
BC8716_RS09900	COG1129	ABC transporter
BC8716_RS09905	COG1172	Belongs to the binding-protein-dependent transport system permease family
BC8716_RS09910	COG1879	ABC-type sugar transport system periplasmic component
BC8716_RS09965	COG1376	ErfK ybiS ycfS ynhG family protein
BC8716_RS09970	COG2312	Erythromycin esterase
BC8716_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS09995	COG2207	Transcriptional regulator
BC8716_RS10000	COG1131	(ABC) transporter
BC8716_RS10010	COG0562	UDP-galactopyranose mutase
BC8716_RS10025	COG1472	Belongs to the glycosyl hydrolase 3 family
BC8716_RS10035	COG0463	Glycosyl transferase, family 2
BC8716_RS10040	COG1472	Belongs to the glycosyl hydrolase 3 family
BC8716_RS10045	COG1378	Sugar-specific transcriptional regulator TrmB
BC8716_RS10050	COG0697	spore germination
BC8716_RS10075	COG1609	Transcriptional regulator
BC8716_RS10080	COG2182	Extracellular solute-binding protein
BC8716_RS10085	COG1175	transmembrane transport
BC8716_RS10090	COG3833	ABC-type maltose transport systems, permease component
BC8716_RS10095	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BC8716_RS10100	COG1874	Beta-galactosidase
BC8716_RS10115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC8716_RS10125	COG0789	Transcriptional regulator
BC8716_RS10145	COG0693	protein deglycase activity
BC8716_RS10155	COG0191	fructose-bisphosphate aldolase activity
BC8716_RS10170	COG0205	6-phosphofructokinase activity
BC8716_RS10175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS10190	COG1136	(ABC) transporter
BC8716_RS10195	COG0577	efflux transmembrane transporter activity
BC8716_RS10205	COG0531	amino acid
BC8716_RS10210	COG0697	spore germination
BC8716_RS10240	COG1414	Transcriptional regulator
BC8716_RS10245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC8716_RS10245	COG2207	Transcriptional regulator
BC8716_RS10250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC8716_RS10255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC8716_RS10260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC8716_RS10265	COG2819	hydrolase of the alpha beta superfamily
BC8716_RS10280	COG2602	Beta-lactamase
BC8716_RS10290	COG0840	transmembrane signaling receptor activity
BC8716_RS10295	COG1609	Transcriptional regulator
BC8716_RS10305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC8716_RS10310	COG2207	Transcriptional regulator
BC8716_RS10320	COG2826	transposase and inactivated derivatives, IS30 family
BC8716_RS10325	COG1609	Transcriptional regulator
BC8716_RS10330	COG0673	inositol 2-dehydrogenase activity
BC8716_RS10345	COG0395	ABC-type sugar transport system, permease component
BC8716_RS10350	COG1082	Xylose isomerase domain protein TIM barrel
BC8716_RS10365	COG2197	response regulator
BC8716_RS10385	COG1366	Belongs to the anti-sigma-factor antagonist family
BC8716_RS10410	COG2720	vancomycin resistance protein
BC8716_RS10420	COG2135	peptidase activity
BC8716_RS10450	COG0542	response to heat
BC8716_RS10455	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC8716_RS10490	COG2311	Membrane
BC8716_RS10495	COG1940	carbohydrate kinase activity
BC8716_RS10505	COG1175	transmembrane transport
BC8716_RS10510	COG0395	ABC-type sugar transport system, permease component
BC8716_RS10515	COG0673	inositol 2-dehydrogenase activity
BC8716_RS10520	COG0673	inositol 2-dehydrogenase activity
BC8716_RS10530	COG0596	Alpha beta hydrolase
BC8716_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS10550	COG0477	Major facilitator Superfamily
BC8716_RS10555	COG1309	transcriptional regulator
BC8716_RS10560	COG2226	methyltransferase
BC8716_RS10565	COG1063	alcohol dehydrogenase
BC8716_RS10580	COG2329	Antibiotic biosynthesis monooxygenase
BC8716_RS10585	COG5386	Cell surface protein
BC8716_RS10590	COG5386	Cell surface protein
BC8716_RS10605	COG1120	ATPase activity
BC8716_RS10610	COG4509	Sortase family
BC8716_RS10615	COG1253	flavin adenine dinucleotide binding
BC8716_RS10630	COG3546	catalase activity
BC8716_RS10635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC8716_RS10640	COG1063	alcohol dehydrogenase
BC8716_RS10645	COG1587	Uroporphyrinogen-III synthase
BC8716_RS10660	COG1131	(ABC) transporter
BC8716_RS10670	COG1309	transcriptional regulator
BC8716_RS10675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BC8716_RS10690	COG2323	membrane
BC8716_RS10700	COG0583	DNA-binding transcription factor activity
BC8716_RS10705	COG0431	NADPH-dependent FMN reductase
BC8716_RS10710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC8716_RS10720	COG1116	anion transmembrane transporter activity
BC8716_RS10725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC8716_RS10730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BC8716_RS10735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC8716_RS10740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BC8716_RS10745	COG0583	DNA-binding transcription factor activity
BC8716_RS10750	COG0640	Transcriptional regulator
BC8716_RS10760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BC8716_RS10775	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS10780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BC8716_RS10790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BC8716_RS10795	COG1653	transport
BC8716_RS10810	COG1609	Transcriptional regulator
BC8716_RS10845	COG4585	Histidine kinase
BC8716_RS10850	COG2197	response regulator
BC8716_RS10855	COG4149	molybdate abc transporter
BC8716_RS10860	COG0725	ABC transporter, periplasmic molybdate-binding protein
BC8716_RS10865	COG1609	Transcriptional regulator
BC8716_RS10875	COG1175	transmembrane transport
BC8716_RS10890	COG3534	alpha-L-arabinofuranosidase
BC8716_RS10900	COG3507	Belongs to the glycosyl hydrolase 43 family
BC8716_RS10905	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC8716_RS10915	COG1682	transport, permease protein
BC8716_RS10920	COG1134	teichoic acid transport
BC8716_RS10925	COG1694	Mazg nucleotide pyrophosphohydrolase
BC8716_RS10945	COG3328	transposase activity
BC8716_RS10955	COG0512	Glutamine amidotransferase of anthranilate synthase
BC8716_RS10955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BC8716_RS10965	COG1216	Glycosyl transferase, family 2
BC8716_RS10970	COG2814	Major facilitator Superfamily
BC8716_RS10990	COG1609	Transcriptional regulator
BC8716_RS10995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BC8716_RS11005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BC8716_RS11010	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BC8716_RS11020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BC8716_RS11030	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BC8716_RS11040	COG2217	Heavy metal translocating P-type atpase
BC8716_RS11055	COG3414	Phosphotransferase system galactitol-specific IIB component
BC8716_RS11060	COG3775	system Galactitol-specific IIC component
BC8716_RS11065	COG1063	alcohol dehydrogenase
BC8716_RS11070	COG1063	alcohol dehydrogenase
BC8716_RS11075	COG0488	(ABC) transporter
BC8716_RS11085	COG1388	LysM domain
BC8716_RS11090	COG1619	proteins homologs of microcin C7 resistance protein MccF
BC8716_RS11095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS11095	COG1263	PTS System
BC8716_RS11100	COG3711	transcriptional antiterminator
BC8716_RS11110	COG2197	response regulator
BC8716_RS11115	COG4585	Histidine kinase
BC8716_RS11130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BC8716_RS11135	COG1228	amidohydrolase
BC8716_RS11145	COG0402	S-adenosylhomocysteine deaminase activity
BC8716_RS11150	COG3314	Sporulation integral membrane protein YlbJ
BC8716_RS11175	COG1078	dGTPase activity
BC8716_RS11200	COG1309	transcriptional regulator
BC8716_RS11225	COG1418	mRNA catabolic process
BC8716_RS11230	COG0124	histidyl-tRNA synthetase
BC8716_RS11240	COG2261	transglycosylase associated protein
BC8716_RS11250	COG3344	reverse transcriptase
BC8716_RS11270	COG1653	transport
BC8716_RS11280	COG0395	ABC-type sugar transport system, permease component
BC8716_RS11290	COG0501	Belongs to the peptidase M48B family
BC8716_RS11315	COG1263	PTS System
BC8716_RS11315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS11315	COG2190	(PTS) system
BC8716_RS11320	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BC8716_RS11325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BC8716_RS11330	COG0583	DNA-binding transcription factor activity
BC8716_RS11335	COG2247	cell wall binding repeat
BC8716_RS11335	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC8716_RS11345	COG1368	sulfuric ester hydrolase activity
BC8716_RS11360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC8716_RS11365	COG0384	phenazine biosynthesis protein PhzF
BC8716_RS11375	COG0673	inositol 2-dehydrogenase activity
BC8716_RS11380	COG2207	Transcriptional regulator
BC8716_RS11380	COG1917	Cupin 2, conserved barrel domain protein
BC8716_RS11390	COG0673	inositol 2-dehydrogenase activity
BC8716_RS11400	COG1175	transmembrane transport
BC8716_RS11405	COG0395	ABC-type sugar transport system, permease component
BC8716_RS11415	COG2207	Transcriptional regulator
BC8716_RS11415	COG3708	Transcriptional regulator
BC8716_RS11425	COG0673	inositol 2-dehydrogenase activity
BC8716_RS11435	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BC8716_RS11440	COG1175	transmembrane transport
BC8716_RS11445	COG0395	ABC-type sugar transport system, permease component
BC8716_RS11465	COG3420	alginic acid biosynthetic process
BC8716_RS11475	COG1309	transcriptional regulator
BC8716_RS11485	COG0583	DNA-binding transcription factor activity
BC8716_RS11490	COG3842	ATPase activity
BC8716_RS11495	COG1840	ABC-type Fe3 transport system, periplasmic component
BC8716_RS11500	COG1177	transmembrane transport
BC8716_RS11530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC8716_RS11555	COG1482	cell wall glycoprotein biosynthetic process
BC8716_RS11560	COG1968	undecaprenyl-diphosphatase activity
BC8716_RS11565	COG2270	Major facilitator Superfamily
BC8716_RS11570	COG3835	regulator
BC8716_RS11575	COG0277	FAD linked oxidase domain protein
BC8716_RS11580	COG0247	lactate metabolic process
BC8716_RS11585	COG1116	anion transmembrane transporter activity
BC8716_RS11600	COG0456	acetyltransferase
BC8716_RS11605	COG1846	Transcriptional regulator
BC8716_RS11620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS11635	COG3730	PTS system glucitol sorbitol-specific
BC8716_RS11640	COG3732	PTS system glucitol sorbitol-specific
BC8716_RS11655	COG3344	reverse transcriptase
BC8716_RS11665	COG2217	Heavy metal translocating P-type atpase
BC8716_RS11670	COG0577	efflux transmembrane transporter activity
BC8716_RS11675	COG1136	(ABC) transporter
BC8716_RS11680	COG5002	protein histidine kinase activity
BC8716_RS11685	COG0745	RESPONSE REGULATOR receiver
BC8716_RS11700	COG1940	carbohydrate kinase activity
BC8716_RS11705	COG4187	Peptidase family M20/M25/M40
BC8716_RS11710	COG2814	Major facilitator Superfamily
BC8716_RS11715	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BC8716_RS11725	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BC8716_RS11730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BC8716_RS11735	COG1349	DNA-binding transcription factor activity
BC8716_RS11740	COG1368	sulfuric ester hydrolase activity
BC8716_RS11745	COG0516	GMP reductase activity
BC8716_RS11760	COG0395	ABC-type sugar transport system, permease component
BC8716_RS11780	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BC8716_RS11785	COG3842	ATPase activity
BC8716_RS11790	COG1177	transmembrane transport
BC8716_RS11800	COG1957	nucleoside hydrolase
BC8716_RS11825	COG0589	response to stress
BC8716_RS11840	COG1105	Belongs to the carbohydrate kinase PfkB family
BC8716_RS11845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS11845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS11845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS11865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BC8716_RS11885	COG1309	transcriptional regulator
BC8716_RS11890	COG0842	Transport permease protein
BC8716_RS11895	COG1131	(ABC) transporter
BC8716_RS11920	COG1473	amidohydrolase
BC8716_RS11925	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BC8716_RS11970	COG0438	transferase activity, transferring glycosyl groups
BC8716_RS11985	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BC8716_RS11995	COG1215	transferase activity, transferring glycosyl groups
BC8716_RS12000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BC8716_RS12070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BC8716_RS12075	COG2169	Transcriptional regulator
BC8716_RS12080	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BC8716_RS12085	COG0673	inositol 2-dehydrogenase activity
BC8716_RS12090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BC8716_RS12095	COG0561	phosphatase activity
BC8716_RS12100	COG2318	DinB family
BC8716_RS12105	COG2378	regulation of single-species biofilm formation
BC8716_RS12115	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS12120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BC8716_RS12130	COG2197	response regulator
BC8716_RS12135	COG2203	Gaf domain
BC8716_RS12135	COG4585	Histidine kinase
BC8716_RS12145	COG2112	serine threonine protein kinase
BC8716_RS12150	COG1959	2 iron, 2 sulfur cluster binding
BC8716_RS12160	COG0800	Aldolase
BC8716_RS12165	COG1476	TRANSCRIPTIONal
BC8716_RS12185	COG1131	(ABC) transporter
BC8716_RS12190	COG1725	Transcriptional regulator
BC8716_RS12210	COG1396	sequence-specific DNA binding
BC8716_RS12220	COG1472	Belongs to the glycosyl hydrolase 3 family
BC8716_RS12230	COG1175	transmembrane transport
BC8716_RS12235	COG0395	ABC-type sugar transport system, permease component
BC8716_RS12240	COG3842	ATPase activity
BC8716_RS12250	COG1609	Transcriptional regulator
BC8716_RS12255	COG4209	transmembrane transport
BC8716_RS12260	COG0395	ABC-type sugar transport system, permease component
BC8716_RS12270	COG1621	beta-fructofuranosidase activity
BC8716_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS12285	COG3858	chitin binding
BC8716_RS12285	COG1388	LysM domain
BC8716_RS12295	COG1335	isochorismatase
BC8716_RS12300	COG4112	unkown
BC8716_RS12305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC8716_RS12310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC8716_RS12325	COG1215	transferase activity, transferring glycosyl groups
BC8716_RS12330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BC8716_RS12335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BC8716_RS12345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BC8716_RS12350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BC8716_RS12350	COG0463	Glycosyl transferase, family 2
BC8716_RS12355	COG1215	transferase activity, transferring glycosyl groups
BC8716_RS12355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BC8716_RS12360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BC8716_RS12365	COG4193	domain, Protein
BC8716_RS12370	COG1316	TRANSCRIPTIONal
BC8716_RS12385	COG4608	Belongs to the ABC transporter superfamily
BC8716_RS12390	COG0601	transmembrane transport
BC8716_RS12400	COG4166	transmembrane transport
BC8716_RS12405	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BC8716_RS12410	COG1739	Uncharacterized protein family UPF0029
BC8716_RS12425	COG1307	EDD domain protein, DegV family
BC8716_RS12430	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BC8716_RS12445	COG2747	anti-sigma28 factor FlgM
BC8716_RS12455	COG4786	Flagellar basal body rod
BC8716_RS12455	COG1256	bacterial-type flagellum assembly
BC8716_RS12460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BC8716_RS12465	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BC8716_RS12470	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BC8716_RS12475	COG1334	flagellar protein FlaG
BC8716_RS12480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BC8716_RS12485	COG1516	flagellar protein fliS
BC8716_RS12500	COG1278	Cold shock
BC8716_RS12505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BC8716_RS12510	COG0653	protein targeting
BC8716_RS12515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BC8716_RS12520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC8716_RS12525	COG2884	Cell division ATP-binding protein ftsE
BC8716_RS12530	COG2177	Part of the ABC transporter FtsEX involved in
BC8716_RS12535	COG0739	heme binding
BC8716_RS12540	COG0793	Belongs to the peptidase S41A family
BC8716_RS12540	COG3409	Peptidoglycan-binding domain 1 protein
BC8716_RS12555	COG0556	nucleotide-excision repair
BC8716_RS12560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BC8716_RS12565	COG3595	metallopeptidase activity
BC8716_RS12570	COG1983	PspC domain protein
BC8716_RS12575	COG1950	PFAM Membrane protein of
BC8716_RS12580	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BC8716_RS12585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BC8716_RS12590	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BC8716_RS12595	COG0546	phosphoglycolate phosphatase activity
BC8716_RS12600	COG0110	maltose O-acetyltransferase activity
BC8716_RS12605	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BC8716_RS12610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BC8716_RS12615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BC8716_RS12620	COG0131	Imidazoleglycerol-phosphate dehydratase
BC8716_RS12625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BC8716_RS12630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BC8716_RS12635	COG0107	imidazoleglycerol-phosphate synthase activity
BC8716_RS12640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BC8716_RS12640	COG0140	phosphoribosyl-ATP diphosphatase activity
BC8716_RS12650	COG1917	Cupin 2, conserved barrel domain protein
BC8716_RS12650	COG2207	Transcriptional regulator
BC8716_RS12655	COG0697	spore germination
BC8716_RS12660	COG2124	cytochrome p450
BC8716_RS12670	COG0492	ferredoxin-NADP+ reductase activity
BC8716_RS12675	COG1051	belongs to the nudix hydrolase family
BC8716_RS12680	COG1660	Displays ATPase and GTPase activities
BC8716_RS12685	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BC8716_RS12690	COG1481	regulation of sporulation
BC8716_RS12695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS12700	COG1174	glycine betaine transport
BC8716_RS12705	COG1732	Glycine betaine
BC8716_RS12710	COG1174	glycine betaine transport
BC8716_RS12715	COG0517	IMP dehydrogenase activity
BC8716_RS12715	COG1125	glycine betaine transport
BC8716_RS12725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC8716_RS12730	COG0740	serine-type endopeptidase activity
BC8716_RS12735	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BC8716_RS12765	COG0126	phosphoglycerate kinase activity
BC8716_RS12770	COG0149	triose-phosphate isomerase activity
BC8716_RS12775	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BC8716_RS12780	COG0148	phosphopyruvate hydratase activity
BC8716_RS12800	COG1695	Transcriptional regulator
BC8716_RS12805	COG1802	Transcriptional regulator
BC8716_RS12810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC8716_RS12815	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS12820	COG4948	Mandelate Racemase Muconate Lactonizing
BC8716_RS12845	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BC8716_RS12850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC8716_RS12860	COG1647	Serine aminopeptidase, S33
BC8716_RS12865	COG0557	exoribonuclease II activity
BC8716_RS12870	COG2259	Doxx family
BC8716_RS12880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BC8716_RS12895	COG3314	Sporulation integral membrane protein YlbJ
BC8716_RS12900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BC8716_RS12905	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BC8716_RS12920	COG4533	DNA binding
BC8716_RS12930	COG1024	Enoyl-CoA hydratase
BC8716_RS12930	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC8716_RS12935	COG0183	Belongs to the thiolase family
BC8716_RS12940	COG1960	acyl-CoA dehydrogenase activity
BC8716_RS12945	COG1393	Belongs to the ArsC family
BC8716_RS12950	COG0509	glycine decarboxylation via glycine cleavage system
BC8716_RS12955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC8716_RS12960	COG2011	ABC-type metal ion transport system permease component
BC8716_RS12965	COG1464	Belongs to the NlpA lipoprotein family
BC8716_RS12975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC8716_RS12980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BC8716_RS12985	COG0396	ATPase activity
BC8716_RS12990	COG0719	Fe-S assembly protein
BC8716_RS12995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BC8716_RS13000	COG0822	iron-sulfur transferase activity
BC8716_RS13005	COG0719	Fe-S assembly protein
BC8716_RS13010	COG0726	polysaccharide deacetylase
BC8716_RS13015	COG5002	protein histidine kinase activity
BC8716_RS13020	COG0745	RESPONSE REGULATOR receiver
BC8716_RS13025	COG2224	Isocitrate lyase
BC8716_RS13035	COG3711	transcriptional antiterminator
BC8716_RS13040	COG2190	(PTS) system
BC8716_RS13040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS13040	COG1263	PTS System
BC8716_RS13045	COG2723	6-phospho-beta-galactosidase activity
BC8716_RS13050	COG2723	6-phospho-beta-galactosidase activity
BC8716_RS13055	COG2226	methyltransferase
BC8716_RS13060	COG0667	Aldo Keto reductase
BC8716_RS13065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC8716_RS13065	COG2207	Transcriptional regulator
BC8716_RS13070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC8716_RS13075	COG2814	Major facilitator Superfamily
BC8716_RS13080	COG0583	DNA-binding transcription factor activity
BC8716_RS13145	COG1801	Protein of unknown function DUF72
BC8716_RS13150	COG0730	response to heat
BC8716_RS13155	COG0737	Belongs to the 5'-nucleotidase family
BC8716_RS13160	COG3377	Domain of unknown function (DUF1805)
BC8716_RS13165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BC8716_RS13180	COG1757	Na H antiporter
BC8716_RS13185	COG0739	heme binding
BC8716_RS13190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BC8716_RS13200	COG4470	Protein conserved in bacteria
BC8716_RS13210	COG2445	Protein of unknown function DUF86
BC8716_RS13215	COG0647	UMP catabolic process
BC8716_RS13220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BC8716_RS13225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BC8716_RS13230	COG0460	homoserine dehydrogenase
BC8716_RS13235	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BC8716_RS13240	COG0083	homoserine kinase activity
BC8716_RS13245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BC8716_RS13250	COG4837	Protein of unknown function (DUF1462)
BC8716_RS13255	COG1252	NADH dehydrogenase
BC8716_RS13260	COG4844	belongs to the
BC8716_RS13270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BC8716_RS13275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BC8716_RS13285	COG0316	Belongs to the HesB IscA family
BC8716_RS13290	COG0765	amino acid transport
BC8716_RS13295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC8716_RS13305	COG3711	transcriptional antiterminator
BC8716_RS13310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS13315	COG0246	Mannitol dehydrogenase
BC8716_RS13320	COG0492	ferredoxin-NADP+ reductase activity
BC8716_RS13325	COG1252	NADH dehydrogenase
BC8716_RS13335	COG3584	3D domain protein
BC8716_RS13340	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BC8716_RS13355	COG2056	Na+-H+ antiporter family
BC8716_RS13360	COG0776	regulation of translation
BC8716_RS13365	COG1295	ribonuclease BN
BC8716_RS13370	COG1854	S-ribosylhomocysteine lyase activity
BC8716_RS13380	COG1522	sequence-specific DNA binding
BC8716_RS13385	COG0436	Aminotransferase
BC8716_RS13390	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BC8716_RS13400	COG1098	S1 RNA binding domain
BC8716_RS13405	COG2155	Conserved Protein
BC8716_RS13410	COG1979	alcohol dehydrogenase
BC8716_RS13415	COG1181	Belongs to the D-alanine--D-alanine ligase family
BC8716_RS13420	COG0166	Belongs to the GPI family
BC8716_RS13440	COG1227	inorganic diphosphatase activity
BC8716_RS13445	COG0109	protoheme IX farnesyltransferase activity
BC8716_RS13450	COG4846	Membrane protein involved in cytochrome C biogenesis
BC8716_RS13470	COG1823	symporter activity
BC8716_RS13475	COG0671	phosphoesterase, PA-phosphatase related
BC8716_RS13480	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC8716_RS13485	COG4605	iron ion homeostasis
BC8716_RS13490	COG4604	ABC transporter, ATP-binding protein
BC8716_RS13505	COG1428	Deoxynucleoside kinase
BC8716_RS13510	COG1428	Deoxynucleoside kinase
BC8716_RS13515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BC8716_RS13525	COG2814	Major facilitator Superfamily
BC8716_RS13530	COG0494	nUDIX hydrolase
BC8716_RS13535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC8716_RS13540	COG1116	anion transmembrane transporter activity
BC8716_RS13545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BC8716_RS13550	COG1506	peptidase
BC8716_RS13560	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BC8716_RS13565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BC8716_RS13570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BC8716_RS13575	COG2267	carboxylic ester hydrolase activity
BC8716_RS13580	COG0288	reversible hydration of carbon dioxide
BC8716_RS13585	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BC8716_RS13590	COG2814	Major facilitator Superfamily
BC8716_RS13595	COG0039	L-malate dehydrogenase activity
BC8716_RS13600	COG0495	leucyl-tRNA aminoacylation
BC8716_RS13630	COG2081	HI0933 family
BC8716_RS13635	COG1473	amidohydrolase
BC8716_RS13640	COG0432	Pfam Uncharacterised protein family UPF0047
BC8716_RS13645	COG3386	PFAM SMP-30 Gluconolaconase
BC8716_RS13650	COG2244	polysaccharide biosynthetic process
BC8716_RS13655	COG0772	Belongs to the SEDS family
BC8716_RS13660	COG0772	Belongs to the SEDS family
BC8716_RS13665	COG1187	pseudouridine synthase activity
BC8716_RS13670	COG1349	DNA-binding transcription factor activity
BC8716_RS13675	COG0346	lactoylglutathione lyase activity
BC8716_RS13690	COG2207	Transcriptional regulator
BC8716_RS13690	COG3708	Transcriptional regulator
BC8716_RS13695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC8716_RS13710	COG1346	cytolysis
BC8716_RS13725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BC8716_RS13730	COG0022	dehydrogenase e1 component
BC8716_RS13735	COG0508	dehydrogenase complex catalyzes the overall conversion of
BC8716_RS13750	COG0788	formyltetrahydrofolate deformylase activity
BC8716_RS13755	COG0510	thiamine kinase activity
BC8716_RS13765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BC8716_RS13775	COG1363	Peptidase, m42
BC8716_RS13780	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BC8716_RS13795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC8716_RS13800	COG4848	Belongs to the UPF0354 family
BC8716_RS13805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC8716_RS13810	COG1674	ftsk spoiiie
BC8716_RS13815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BC8716_RS13820	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BC8716_RS13825	COG4980	gas vesicle protein
BC8716_RS13830	COG1605	Chorismate mutase
BC8716_RS13830	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BC8716_RS13840	COG0123	including yeast histone deacetylase and acetoin utilization protein
BC8716_RS13845	COG0517	IMP dehydrogenase activity
BC8716_RS13850	COG0454	-acetyltransferase
BC8716_RS13855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC8716_RS13860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC8716_RS13865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BC8716_RS13870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BC8716_RS13875	COG1956	GAF domain-containing protein
BC8716_RS13885	COG1309	transcriptional regulator
BC8716_RS13890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BC8716_RS13895	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BC8716_RS13900	COG1104	cysteine desulfurase activity
BC8716_RS13905	COG0301	tRNA thio-modification
BC8716_RS13915	COG0616	signal peptide processing
BC8716_RS13920	COG1714	RDD family
BC8716_RS13930	COG3874	Sporulation protein YtfJ
BC8716_RS13935	COG2814	Major facilitator Superfamily
BC8716_RS13940	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BC8716_RS13945	COG0827	DNA restriction-modification system
BC8716_RS13950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BC8716_RS13955	COG3481	metal-dependent phosphohydrolase, HD sub domain
BC8716_RS13965	COG0137	argininosuccinate synthase activity
BC8716_RS13970	COG0165	Argininosuccinate lyase
BC8716_RS13975	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS13985	COG0006	proline dipeptidase activity
BC8716_RS13990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BC8716_RS14000	COG4109	DRTGG domain
BC8716_RS14010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BC8716_RS14025	COG0587	DNA-directed DNA polymerase activity
BC8716_RS14030	COG0281	malic enzyme
BC8716_RS14035	COG2186	Transcriptional regulator
BC8716_RS14040	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BC8716_RS14045	COG0825	malonyl-CoA metabolic process
BC8716_RS14050	COG0205	6-phosphofructokinase activity
BC8716_RS14060	COG3030	protein affecting phage T7 exclusion by the F plasmid
BC8716_RS14065	COG2707	UPF0756 membrane protein
BC8716_RS14070	COG0372	Belongs to the citrate synthase family
BC8716_RS14075	COG0538	isocitrate dehydrogenase activity
BC8716_RS14080	COG0039	L-malate dehydrogenase activity
BC8716_RS14085	COG1522	sequence-specific DNA binding
BC8716_RS14090	COG0745	RESPONSE REGULATOR receiver
BC8716_RS14095	COG5002	protein histidine kinase activity
BC8716_RS14100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC8716_RS14100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC8716_RS14105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BC8716_RS14110	COG1971	Probably functions as a manganese efflux pump
BC8716_RS14115	COG0237	dephospho-CoA kinase activity
BC8716_RS14120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BC8716_RS14125	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BC8716_RS14135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BC8716_RS14140	COG3611	Membrane attachment protein
BC8716_RS14145	COG1484	DNA-dependent DNA replication
BC8716_RS14150	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BC8716_RS14160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BC8716_RS14175	COG2027	D-alanyl-D-alanine carboxypeptidase
BC8716_RS14190	COG1136	(ABC) transporter
BC8716_RS14195	COG0577	efflux transmembrane transporter activity
BC8716_RS14200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BC8716_RS14205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BC8716_RS14210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BC8716_RS14215	COG3162	membrane
BC8716_RS14220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC8716_RS14230	COG1363	Peptidase, m42
BC8716_RS14250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC8716_RS14255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BC8716_RS14260	COG0072	phenylalanine-tRNA ligase activity
BC8716_RS14265	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BC8716_RS14270	COG1286	toxin biosynthetic process
BC8716_RS14275	COG1796	DNA polymerase
BC8716_RS14275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BC8716_RS14280	COG1193	negative regulation of DNA recombination
BC8716_RS14285	COG3766	membrane
BC8716_RS14290	COG0318	PFAM AMP-dependent synthetase and ligase
BC8716_RS14295	COG1309	transcriptional regulator
BC8716_RS14300	COG1024	Enoyl-CoA hydratase
BC8716_RS14305	COG2086	electron transfer activity
BC8716_RS14310	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BC8716_RS14315	COG3118	belongs to the thioredoxin family
BC8716_RS14320	COG0322	excinuclease ABC activity
BC8716_RS14330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BC8716_RS14335	COG2009	succinate dehydrogenase
BC8716_RS14340	COG1053	succinate dehydrogenase
BC8716_RS14345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BC8716_RS14350	COG0824	Thioesterase
BC8716_RS14355	COG2197	response regulator
BC8716_RS14365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS14370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BC8716_RS14375	COG1846	Transcriptional regulator
BC8716_RS14380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BC8716_RS14390	COG1054	Belongs to the UPF0176 family
BC8716_RS14395	COG5401	PFAM Sporulation and spore germination
BC8716_RS14400	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BC8716_RS14405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BC8716_RS14410	COG0622	Phosphoesterase
BC8716_RS14430	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BC8716_RS14445	COG2826	transposase and inactivated derivatives, IS30 family
BC8716_RS14450	COG2132	Multicopper oxidase
BC8716_RS14465	COG0129	dihydroxy-acid dehydratase activity
BC8716_RS14470	COG0028	Belongs to the TPP enzyme family
BC8716_RS14475	COG0440	acetolactate synthase activity
BC8716_RS14480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BC8716_RS14485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BC8716_RS14490	COG0473	3-isopropylmalate dehydrogenase activity
BC8716_RS14495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BC8716_RS14500	COG0066	3-isopropylmalate dehydratase activity
BC8716_RS14505	COG0457	Tetratricopeptide repeat
BC8716_RS14505	COG1477	protein flavinylation
BC8716_RS14510	COG0544	peptidyl-prolyl cis-trans isomerase activity
BC8716_RS14515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BC8716_RS14520	COG1067	ATP-dependent peptidase activity
BC8716_RS14520	COG0470	DNA polymerase III
BC8716_RS14525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BC8716_RS14530	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BC8716_RS14535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BC8716_RS14540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BC8716_RS14545	COG0181	hydroxymethylbilane synthase activity
BC8716_RS14555	COG0113	porphobilinogen synthase activity
BC8716_RS14560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BC8716_RS14565	COG1388	LysM domain
BC8716_RS14565	COG1388	LysM domain
BC8716_RS14590	COG0525	valine-tRNA ligase activity
BC8716_RS14595	COG0285	dihydrofolate synthase activity
BC8716_RS14600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BC8716_RS14610	COG4946	Tricorn protease homolog
BC8716_RS14610	COG1506	peptidase
BC8716_RS14610	COG0823	Involved in the tonB-independent uptake of proteins
BC8716_RS14615	COG0424	maF-like protein
BC8716_RS14620	COG2003	Belongs to the UPF0758 family
BC8716_RS14625	COG1077	Cell shape determining protein MreB Mrl
BC8716_RS14635	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BC8716_RS14640	COG0850	regulation of cytokinetic process
BC8716_RS14645	COG2894	cell division
BC8716_RS14650	COG0693	protein deglycase activity
BC8716_RS14655	COG0315	cyclic pyranopterin monophosphate synthase activity
BC8716_RS14660	COG1268	BioY protein
BC8716_RS14665	COG0667	Aldo Keto reductase
BC8716_RS14670	COG0739	heme binding
BC8716_RS14675	COG1994	Peptidase M50
BC8716_RS14680	COG1530	ribonuclease E activity
BC8716_RS14685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BC8716_RS14690	COG2868	ribosomal protein
BC8716_RS14695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BC8716_RS14700	COG2002	toxin-antitoxin pair type II binding
BC8716_RS14705	COG1228	amidohydrolase
BC8716_RS14710	COG1573	uracil-dna glycosylase
BC8716_RS14715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC8716_RS14720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BC8716_RS14730	COG2318	DinB family
BC8716_RS14740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BC8716_RS14745	COG0573	inorganic phosphate transmembrane transporter activity
BC8716_RS14750	COG0581	inorganic phosphate transmembrane transporter activity
BC8716_RS14755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC8716_RS14760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC8716_RS14785	COG0643	Histidine kinase
BC8716_RS14785	COG2198	Histidine kinase
BC8716_RS14790	COG0835	chemotaxis
BC8716_RS14795	COG0367	asparagine synthase
BC8716_RS14805	COG1834	amidinotransferase
BC8716_RS14810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BC8716_RS14820	COG0425	Belongs to the sulfur carrier protein TusA family
BC8716_RS14820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC8716_RS14830	COG1073	alpha beta
BC8716_RS14835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC8716_RS14845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BC8716_RS14865	COG0561	phosphatase activity
BC8716_RS14870	COG3336	cytochrome c oxidase
BC8716_RS14875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BC8716_RS14880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BC8716_RS14885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BC8716_RS14890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BC8716_RS14895	COG0505	Belongs to the CarA family
BC8716_RS14900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BC8716_RS14905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BC8716_RS14910	COG2267	carboxylic ester hydrolase activity
BC8716_RS14915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC8716_RS14920	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BC8716_RS14935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC8716_RS14940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC8716_RS14945	COG0617	tRNA 3'-terminal CCA addition
BC8716_RS14955	COG3773	Cell wall hydrolase
BC8716_RS14955	COG3409	Peptidoglycan-binding domain 1 protein
BC8716_RS14960	COG2340	Cysteine-rich secretory protein family
BC8716_RS14965	COG1072	(Pantothenic acid kinase))
BC8716_RS14970	COG2357	RelA SpoT domain protein
BC8716_RS14975	COG5504	Zn-dependent protease
BC8716_RS14985	COG0180	Tryptophanyl-tRNA synthetase
BC8716_RS14995	COG1418	mRNA catabolic process
BC8716_RS15000	COG1272	protein, Hemolysin III
BC8716_RS15015	COG0456	acetyltransferase
BC8716_RS15020	COG1393	Belongs to the ArsC family
BC8716_RS15025	COG4862	establishment of competence for transformation
BC8716_RS15040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BC8716_RS15045	COG2346	COG2346, Truncated hemoglobins
BC8716_RS15050	COG0741	lytic transglycosylase activity
BC8716_RS15065	COG2357	RelA SpoT domain protein
BC8716_RS15070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BC8716_RS15075	COG0564	pseudouridine synthase activity
BC8716_RS15090	COG2226	methyltransferase
BC8716_RS15120	COG0210	DNA helicase
BC8716_RS15125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BC8716_RS15180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BC8716_RS15185	COG4537	Required for transformation and DNA binding
BC8716_RS15220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC8716_RS15235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BC8716_RS15240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BC8716_RS15245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BC8716_RS15250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BC8716_RS15255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC8716_RS15260	COG0095	Lipoate-protein ligase
BC8716_RS15265	COG3973	AAA domain
BC8716_RS15275	COG1533	DNA photolyase activity
BC8716_RS15280	COG1321	iron dependent repressor
BC8716_RS15285	COG1752	Esterase of the alpha-beta hydrolase superfamily
BC8716_RS15300	COG0006	proline dipeptidase activity
BC8716_RS15305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BC8716_RS15310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BC8716_RS15325	COG3854	ATPases associated with a variety of cellular activities
BC8716_RS15370	COG0511	ligase activity, forming carbon-carbon bonds
BC8716_RS15375	COG0439	Biotin carboxylase
BC8716_RS15380	COG1302	Protein conserved in bacteria
BC8716_RS15385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC8716_RS15390	COG1570	exodeoxyribonuclease VII activity
BC8716_RS15395	COG1722	exodeoxyribonuclease VII activity
BC8716_RS15400	COG0142	geranyltranstransferase activity
BC8716_RS15405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BC8716_RS15410	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BC8716_RS15415	COG1438	arginine binding
BC8716_RS15425	COG0750	zinc metalloprotease
BC8716_RS15430	COG0745	RESPONSE REGULATOR receiver
BC8716_RS15445	COG3290	protein histidine kinase activity
BC8716_RS15445	COG3829	transcription factor binding
BC8716_RS15455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BC8716_RS15460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BC8716_RS15465	COG0022	dehydrogenase e1 component
BC8716_RS15470	COG0508	dehydrogenase complex catalyzes the overall conversion of
BC8716_RS15580	COG5280	Phage tail tape measure protein TP901
BC8716_RS15580	COG3953	SLT domain
BC8716_RS15590	COG5434	Belongs to the glycosyl hydrolase 28 family
BC8716_RS15625	COG4824	toxin secretion phage lysis holin
BC8716_RS15640	COG1793	dna ligase
BC8716_RS15685	COG3645	SOS response
BC8716_RS15685	COG3646	Phage regulatory protein
BC8716_RS15740	COG2226	methyltransferase
BC8716_RS15775	COG0561	phosphatase activity
BC8716_RS15785	COG1937	Protein conserved in bacteria
BC8716_RS15790	COG2608	mercury ion transmembrane transporter activity
BC8716_RS15805	COG1902	pentaerythritol trinitrate reductase activity
BC8716_RS15815	COG0702	epimerase
BC8716_RS15835	COG0668	transmembrane transport
BC8716_RS15850	COG2171	N-acyltransferase activity
BC8716_RS15855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BC8716_RS15860	COG1473	amidohydrolase
BC8716_RS15870	COG0668	transmembrane transport
BC8716_RS15875	COG0450	alkyl hydroperoxide reductase
BC8716_RS15880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC8716_RS15885	COG0569	domain protein
BC8716_RS15890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BC8716_RS15895	COG5503	Protein of unknown function (DUF1447)
BC8716_RS15900	COG0242	peptide deformylase activity
BC8716_RS15920	COG0022	dehydrogenase e1 component
BC8716_RS15925	COG0508	dehydrogenase complex catalyzes the overall conversion of
BC8716_RS15935	COG3344	reverse transcriptase
BC8716_RS15940	COG0444	Belongs to the ABC transporter superfamily
BC8716_RS15945	COG4608	Belongs to the ABC transporter superfamily
BC8716_RS15955	COG0601	transmembrane transport
BC8716_RS15960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC8716_RS15970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BC8716_RS15990	COG1982	Orn Lys Arg decarboxylase major
BC8716_RS16000	COG4493	Belongs to the UPF0637 family
BC8716_RS16005	COG0483	inositol monophosphate 1-phosphatase activity
BC8716_RS16020	COG1217	gtp-binding protein TYPA
BC8716_RS16030	COG4896	Protein conserved in bacteria
BC8716_RS16035	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BC8716_RS16040	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BC8716_RS16045	COG4838	Belongs to the UPF0358 family
BC8716_RS16050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BC8716_RS16055	COG1612	heme a metabolic process
BC8716_RS16060	COG2010	Cytochrome c
BC8716_RS16060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BC8716_RS16065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC8716_RS16070	COG1845	cytochrome c oxidase, subunit III
BC8716_RS16075	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BC8716_RS16080	COG2322	membrane
BC8716_RS16095	COG2340	Cysteine-rich secretory protein family
BC8716_RS16120	COG3679	Belongs to the UPF0342 family
BC8716_RS16125	COG4471	UPF0298 protein
BC8716_RS16135	COG0742	ribosomal rna small subunit methyltransferase
BC8716_RS16140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BC8716_RS16145	COG3314	Sporulation integral membrane protein YlbJ
BC8716_RS16150	COG1752	Esterase of the alpha-beta hydrolase superfamily
BC8716_RS16155	COG3480	Lon protease (S16) C-terminal proteolytic domain
BC8716_RS16160	COG1323	Belongs to the UPF0348 family
BC8716_RS16165	COG1399	metal-binding, possibly nucleic acid-binding protein
BC8716_RS16170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BC8716_RS16180	COG0454	-acetyltransferase
BC8716_RS16185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BC8716_RS16195	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BC8716_RS16200	COG2001	Belongs to the MraZ family
BC8716_RS16205	COG0275	rRNA processing
BC8716_RS16210	COG4839	cell division protein FtsL
BC8716_RS16215	COG0768	penicillin binding
BC8716_RS16220	COG0768	penicillin binding
BC8716_RS16225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BC8716_RS16230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BC8716_RS16235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BC8716_RS16240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BC8716_RS16245	COG0772	Belongs to the SEDS family
BC8716_RS16250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BC8716_RS16255	COG0849	cell division
BC8716_RS16260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BC8716_RS16270	COG1191	sigma factor activity
BC8716_RS16275	COG1191	sigma factor activity
BC8716_RS16280	COG1873	PFAM PRC-barrel domain
BC8716_RS16290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BC8716_RS16295	COG1799	cell septum assembly
BC8716_RS16300	COG0762	integral membrane protein
BC8716_RS16305	COG2302	S4 RNA-binding domain
BC8716_RS16310	COG3599	regulation of cell shape
BC8716_RS16315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BC8716_RS16320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BC8716_RS16325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BC8716_RS16330	COG0564	pseudouridine synthase activity
BC8716_RS16335	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BC8716_RS16340	COG2233	PERMEase
BC8716_RS16345	COG0540	Belongs to the ATCase OTCase family
BC8716_RS16350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BC8716_RS16355	COG0505	Belongs to the CarA family
BC8716_RS16360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BC8716_RS16365	COG0543	2 iron, 2 sulfur cluster binding
BC8716_RS16370	COG0167	dihydroorotate dehydrogenase activity
BC8716_RS16375	COG0284	orotidine-5'-phosphate decarboxylase activity
BC8716_RS16380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BC8716_RS16385	COG2226	methyltransferase
BC8716_RS16395	COG4485	Bacterial membrane protein, YfhO
BC8716_RS16405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC8716_RS16410	COG2052	Domain of unknown function (DUF370)
BC8716_RS16415	COG0194	GDP metabolic process
BC8716_RS16420	COG1758	RNA polymerase activity
BC8716_RS16425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BC8716_RS16430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BC8716_RS16435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BC8716_RS16440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC8716_RS16440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BC8716_RS16445	COG0631	protein serine/threonine phosphatase activity
BC8716_RS16450	COG2815	serine threonine protein kinase
BC8716_RS16450	COG0515	serine threonine protein kinase
BC8716_RS16455	COG1162	GTPase activity
BC8716_RS16460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BC8716_RS16470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BC8716_RS16475	COG1302	Protein conserved in bacteria
BC8716_RS16480	COG1461	Dihydroxyacetone kinase
BC8716_RS16485	COG1307	EDD domain protein, DegV family
BC8716_RS16490	COG1760	l-serine dehydratase
BC8716_RS16495	COG1760	l-serine dehydratase
BC8716_RS16500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BC8716_RS16505	COG1349	DNA-binding transcription factor activity
BC8716_RS16510	COG0416	fatty acid biosynthetic process
BC8716_RS16515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BC8716_RS16520	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS16525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC8716_RS16530	COG0571	ribonuclease III activity
BC8716_RS16540	COG1196	nuclear chromosome segregation
BC8716_RS16545	COG0552	protein localization to endoplasmic reticulum
BC8716_RS16550	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BC8716_RS16555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BC8716_RS16560	COG0228	four-way junction DNA binding
BC8716_RS16565	COG1837	Belongs to the UPF0109 family
BC8716_RS16575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BC8716_RS16580	COG0336	Belongs to the RNA methyltransferase TrmD family
BC8716_RS16585	COG0018	arginyl-trna synthetase
BC8716_RS16590	COG0335	large ribosomal subunit rRNA binding
BC8716_RS16600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC8716_RS16630	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS16635	COG3836	Belongs to the HpcH HpaI aldolase family
BC8716_RS16670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BC8716_RS16690	COG0045	succinate-CoA ligase (ADP-forming) activity
BC8716_RS16695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BC8716_RS16700	COG0758	DNA mediated transformation
BC8716_RS16705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC8716_RS16710	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BC8716_RS16715	COG4974	Belongs to the 'phage' integrase family
BC8716_RS16720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BC8716_RS16725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BC8716_RS16730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BC8716_RS16735	COG1815	bacterial-type flagellum-dependent cell motility
BC8716_RS16740	COG1558	bacterial-type flagellum-dependent cell motility
BC8716_RS16745	COG1677	Flagellar hook-basal body complex protein FliE
BC8716_RS16750	COG1766	The M ring may be actively involved in energy transduction
BC8716_RS16755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BC8716_RS16760	COG1317	bacterial-type flagellum organization
BC8716_RS16765	COG1157	protein secretion by the type III secretion system
BC8716_RS16785	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BC8716_RS16790	COG4786	Flagellar basal body rod
BC8716_RS16805	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BC8716_RS16810	COG1776	CheC inhibitor of MCP methylation
BC8716_RS16810	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BC8716_RS16815	COG2201	protein-glutamate methylesterase activity
BC8716_RS16820	COG3190	flagellar
BC8716_RS16825	COG1338	Plays a role in the flagellum-specific transport system
BC8716_RS16830	COG1987	bacterial-type flagellum assembly
BC8716_RS16835	COG1684	flagellar biosynthetic protein fliR
BC8716_RS16840	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BC8716_RS16845	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BC8716_RS16850	COG1419	protein localization to endoplasmic reticulum
BC8716_RS16860	COG2201	protein-glutamate methylesterase activity
BC8716_RS16870	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BC8716_RS16875	COG1191	sigma factor activity
BC8716_RS16885	COG0052	Belongs to the universal ribosomal protein uS2 family
BC8716_RS16890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BC8716_RS16895	COG0528	UMP kinase activity
BC8716_RS16900	COG0233	cytoplasmic translational termination
BC8716_RS16905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BC8716_RS16910	COG4589	Belongs to the CDS family
BC8716_RS16915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BC8716_RS16920	COG0750	zinc metalloprotease
BC8716_RS16925	COG0442	prolyl-tRNA aminoacylation
BC8716_RS16930	COG2176	DNA-directed DNA polymerase activity
BC8716_RS16935	COG0779	Required for maturation of 30S ribosomal subunits
BC8716_RS16940	COG0195	Participates in both transcription termination and antitermination
BC8716_RS16945	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BC8716_RS16950	COG1358	cellular component organization or biogenesis
BC8716_RS16955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BC8716_RS16965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BC8716_RS16970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BC8716_RS16975	COG0196	riboflavin kinase activity
BC8716_RS16980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BC8716_RS16985	COG1185	polyribonucleotide nucleotidyltransferase activity
BC8716_RS16990	COG0726	polysaccharide deacetylase
BC8716_RS16995	COG0612	Peptidase, M16
BC8716_RS17005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC8716_RS17010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BC8716_RS17015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BC8716_RS17020	COG0527	aspartate kinase activity
BC8716_RS17025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC8716_RS17030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BC8716_RS17035	COG0740	serine-type endopeptidase activity
BC8716_RS17045	COG1674	ftsk spoiiie
BC8716_RS17050	COG2188	Transcriptional regulator
BC8716_RS17055	COG0612	Peptidase, M16
BC8716_RS17060	COG0612	Peptidase, M16
BC8716_RS17065	COG0300	oxidoreductase activity
BC8716_RS17080	COG1426	Protein conserved in bacteria
BC8716_RS17085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BC8716_RS17090	COG1058	Belongs to the CinA family
BC8716_RS17090	COG1546	Belongs to the CinA family
BC8716_RS17095	COG0513	Belongs to the DEAD box helicase family
BC8716_RS17100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BC8716_RS17110	COG0497	DNA recombination
BC8716_RS17125	COG1418	mRNA catabolic process
BC8716_RS17130	COG1692	metallophosphoesterase
BC8716_RS17135	COG2359	stage V sporulation protein S
BC8716_RS17145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BC8716_RS17150	COG4550	Control of competence regulator ComK, YlbF/YmcA
BC8716_RS17160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BC8716_RS17165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BC8716_RS17175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BC8716_RS17180	COG1923	regulation of RNA biosynthetic process
BC8716_RS17190	COG0464	growth
BC8716_RS17195	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BC8716_RS17200	COG0174	glutamine synthetase
BC8716_RS17205	COG0277	FAD linked oxidase domain protein
BC8716_RS17210	COG0247	lactate metabolic process
BC8716_RS17215	COG0277	FAD linked oxidase domain protein
BC8716_RS17220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BC8716_RS17225	COG0179	Fumarylacetoacetate (FAA) hydrolase
BC8716_RS17230	COG1414	Transcriptional regulator
BC8716_RS17245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BC8716_RS17250	COG2814	Major facilitator Superfamily
BC8716_RS17255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BC8716_RS17260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BC8716_RS17265	COG4224	UPF0291 protein
BC8716_RS17270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BC8716_RS17280	COG3763	UPF0154 protein
BC8716_RS17285	COG1132	(ABC) transporter
BC8716_RS17290	COG1132	(ABC) transporter
BC8716_RS17315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BC8716_RS17335	COG0464	growth
BC8716_RS17340	COG0824	Thioesterase
BC8716_RS17345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BC8716_RS17365	COG2200	EAL domain
BC8716_RS17390	COG0835	chemotaxis
BC8716_RS17390	COG0784	Response regulator, receiver
BC8716_RS17400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC8716_RS17420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC8716_RS17430	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BC8716_RS17440	COG1254	Belongs to the acylphosphatase family
BC8716_RS17445	COG1115	amino acid carrier protein
BC8716_RS17450	COG2309	aminopeptidase activity
BC8716_RS17455	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BC8716_RS17460	COG0720	synthase
BC8716_RS17465	COG0602	queuosine metabolic process
BC8716_RS17470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BC8716_RS17480	COG4585	Histidine kinase
BC8716_RS17495	COG1131	(ABC) transporter
BC8716_RS17505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC8716_RS17505	COG0551	DNA topoisomerase type I activity
BC8716_RS17510	COG1764	response to oxidative stress
BC8716_RS17530	COG0567	Dehydrogenase, E1 component
BC8716_RS17535	COG0508	dehydrogenase complex catalyzes the overall conversion of
BC8716_RS17550	COG0488	(ABC) transporter
BC8716_RS17555	COG0656	L-ascorbic acid biosynthetic process
BC8716_RS17560	COG0514	ATP-dependent DNA helicase (RecQ)
BC8716_RS17580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC8716_RS17585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BC8716_RS17590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BC8716_RS17595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC8716_RS17600	COG4876	unkown
BC8716_RS17605	COG1960	acyl-CoA dehydrogenase activity
BC8716_RS17610	COG3069	C4-dicarboxylate transmembrane transporter activity
BC8716_RS17630	COG1595	DNA-templated transcription, initiation
BC8716_RS17680	COG0561	phosphatase activity
BC8716_RS17685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS17685	COG1263	PTS System
BC8716_RS17690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BC8716_RS17725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS17725	COG1263	PTS System
BC8716_RS17730	COG3394	polysaccharide catabolic process
BC8716_RS17735	COG1486	melibiose metabolic process
BC8716_RS17740	COG2188	Transcriptional regulator
BC8716_RS17750	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC8716_RS17775	COG0438	transferase activity, transferring glycosyl groups
BC8716_RS17780	COG0617	tRNA 3'-terminal CCA addition
BC8716_RS17790	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BC8716_RS17795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BC8716_RS17800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BC8716_RS17810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BC8716_RS17810	COG1199	ATP-dependent helicase activity
BC8716_RS17815	COG0402	S-adenosylhomocysteine deaminase activity
BC8716_RS17835	COG0017	Asparaginyl-tRNA synthetase
BC8716_RS17840	COG3935	DnaD domain protein
BC8716_RS17845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BC8716_RS17850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BC8716_RS17855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC8716_RS17855	COG4499	WXG100 protein secretion system (Wss), protein YukC
BC8716_RS17860	COG3331	DNA recombination
BC8716_RS17870	COG0789	Transcriptional regulator
BC8716_RS17885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BC8716_RS17890	COG0693	protein deglycase activity
BC8716_RS17895	COG1234	tRNA 3'-trailer cleavage
BC8716_RS17920	COG1413	lyase activity
BC8716_RS17930	COG3402	PFAM membrane-flanked domain
BC8716_RS17935	COG3428	Bacterial PH domain
BC8716_RS17960	COG0069	glutamate synthase activity
BC8716_RS17960	COG0070	glutamate synthase
BC8716_RS17960	COG0067	glutamate synthase
BC8716_RS17965	COG0493	'glutamate synthase
BC8716_RS18005	COG0561	phosphatase activity
BC8716_RS18015	COG0346	lactoylglutathione lyase activity
BC8716_RS18020	COG0400	carboxylic ester hydrolase activity
BC8716_RS18035	COG0814	amino acid
BC8716_RS18040	COG0697	spore germination
BC8716_RS18050	COG1205	dead DEAH box helicase
BC8716_RS18050	COG1111	helicase
BC8716_RS18055	COG3359	exonuclease
BC8716_RS18065	COG4474	Belongs to the UPF0398 family
BC8716_RS18070	COG3599	regulation of cell shape
BC8716_RS18075	COG0328	RNA-DNA hybrid ribonuclease activity
BC8716_RS18090	COG0116	Belongs to the methyltransferase superfamily
BC8716_RS18095	COG0673	inositol 2-dehydrogenase activity
BC8716_RS18100	COG3960	tartronate-semialdehyde synthase activity
BC8716_RS18105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BC8716_RS18115	COG3290	protein histidine kinase activity
BC8716_RS18115	COG0840	transmembrane signaling receptor activity
BC8716_RS18155	COG1070	Carbohydrate kinase
BC8716_RS18185	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BC8716_RS18195	COG1396	sequence-specific DNA binding
BC8716_RS18205	COG2364	Membrane
BC8716_RS18215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BC8716_RS18230	COG2723	6-phospho-beta-galactosidase activity
BC8716_RS18235	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS18240	COG0517	IMP dehydrogenase activity
BC8716_RS18240	COG1125	glycine betaine transport
BC8716_RS18250	COG1832	CoA-binding protein
BC8716_RS18255	COG0187	DNA topoisomerase II activity
BC8716_RS18260	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BC8716_RS18270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BC8716_RS18275	COG0628	permease
BC8716_RS18280	COG1360	Flagellar Motor Protein
BC8716_RS18285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BC8716_RS18290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC8716_RS18305	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BC8716_RS18310	COG1413	lyase activity
BC8716_RS18325	COG0596	Alpha beta hydrolase
BC8716_RS18350	COG0778	Nitroreductase
BC8716_RS18355	COG0778	Nitroreductase
BC8716_RS18375	COG1595	DNA-templated transcription, initiation
BC8716_RS18385	COG1131	(ABC) transporter
BC8716_RS18405	COG3708	Transcriptional regulator
BC8716_RS18405	COG2207	Transcriptional regulator
BC8716_RS18425	COG2814	Major facilitator Superfamily
BC8716_RS18450	COG0733	neurotransmitter:sodium symporter activity
BC8716_RS18460	COG2151	metal-sulfur cluster biosynthetic enzyme
BC8716_RS18470	COG0697	spore germination
BC8716_RS18475	COG0217	transcriptional regulatory protein
BC8716_RS18480	COG0708	Exodeoxyribonuclease III
BC8716_RS18485	COG3048	D-serine ammonia-lyase activity
BC8716_RS18490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BC8716_RS18495	COG1082	Xylose isomerase domain protein TIM barrel
BC8716_RS18505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC8716_RS18525	COG2329	Antibiotic biosynthesis monooxygenase
BC8716_RS18530	COG0626	cystathionine gamma-synthase activity
BC8716_RS18535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC8716_RS18540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC8716_RS18550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC8716_RS18555	COG1309	transcriptional regulator
BC8716_RS18565	COG1388	LysM domain
BC8716_RS18565	COG0791	NLP P60 protein
BC8716_RS18580	COG2094	Belongs to the DNA glycosylase MPG family
BC8716_RS18585	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BC8716_RS18590	COG1122	ATPase activity
BC8716_RS18600	COG1011	Hydrolase
BC8716_RS18605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BC8716_RS18610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BC8716_RS18615	COG1388	LysM domain
BC8716_RS18615	COG3584	3D domain protein
BC8716_RS18620	COG1388	LysM domain
BC8716_RS18620	COG3584	3D domain protein
BC8716_RS18625	COG2226	methyltransferase
BC8716_RS18630	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BC8716_RS18640	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BC8716_RS18655	COG2153	protein acetylation
BC8716_RS18665	COG1690	Belongs to the RtcB family
BC8716_RS18675	COG1803	Methylglyoxal synthase
BC8716_RS18680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BC8716_RS18685	COG1694	Mazg nucleotide pyrophosphohydrolase
BC8716_RS18690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC8716_RS18695	COG2814	Major facilitator Superfamily
BC8716_RS18700	COG2738	Putative neutral zinc metallopeptidase
BC8716_RS18710	COG4347	Protein of unknown function (DUF1405)
BC8716_RS18720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BC8716_RS18725	COG0723	plastoquinol--plastocyanin reductase activity
BC8716_RS18735	COG5582	Belongs to the UPF0302 family
BC8716_RS18740	COG0457	Tetratricopeptide repeat
BC8716_RS18745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BC8716_RS18750	COG0287	Prephenate dehydrogenase
BC8716_RS18755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BC8716_RS18760	COG0159	tryptophan synthase activity
BC8716_RS18765	COG0133	tryptophan synthase activity
BC8716_RS18770	COG0135	phosphoribosylanthranilate isomerase activity
BC8716_RS18775	COG0134	indole-3-glycerol-phosphate synthase activity
BC8716_RS18780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BC8716_RS18790	COG4401	Chorismate mutase type I
BC8716_RS18795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BC8716_RS18800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BC8716_RS18805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BC8716_RS18810	COG0105	UTP biosynthetic process
BC8716_RS18815	COG0142	geranyltranstransferase activity
BC8716_RS18825	COG0109	protoheme IX farnesyltransferase activity
BC8716_RS18830	COG2226	methyltransferase
BC8716_RS18835	COG0142	geranyltranstransferase activity
BC8716_RS18845	COG0302	gtp cyclohydrolase
BC8716_RS18850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BC8716_RS18870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BC8716_RS18875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BC8716_RS18880	COG1160	GTP binding
BC8716_RS18890	COG0539	negative regulation of cytoplasmic translation
BC8716_RS18895	COG0204	Acyl-transferase
BC8716_RS18900	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BC8716_RS18905	COG2959	enzyme of heme biosynthesis
BC8716_RS18910	COG3773	Cell wall hydrolase
BC8716_RS18910	COG3409	Peptidoglycan-binding domain 1 protein
BC8716_RS18915	COG1410	methionine synthase
BC8716_RS18915	COG0646	methionine synthase
BC8716_RS18920	COG0646	methionine synthase
BC8716_RS18920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BC8716_RS18925	COG0626	cystathionine gamma-synthase activity
BC8716_RS18930	COG2339	peptidase activity
BC8716_RS18940	COG0492	ferredoxin-NADP+ reductase activity
BC8716_RS18945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BC8716_RS18955	COG5002	protein histidine kinase activity
BC8716_RS18960	COG0745	RESPONSE REGULATOR receiver
BC8716_RS18965	COG4862	establishment of competence for transformation
BC8716_RS18970	COG0789	Transcriptional regulator
BC8716_RS18975	COG1408	metallophosphoesterase
BC8716_RS18985	COG1473	amidohydrolase
BC8716_RS18995	COG0438	transferase activity, transferring glycosyl groups
BC8716_RS19000	COG0438	transferase activity, transferring glycosyl groups
BC8716_RS19030	COG1266	CAAX protease self-immunity
BC8716_RS19035	COG0514	ATP-dependent DNA helicase (RecQ)
BC8716_RS19040	COG4955	Helix-turn-helix domain
BC8716_RS19050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BC8716_RS19055	COG0446	pyridine nucleotide-disulphide oxidoreductase
BC8716_RS19060	COG0861	Integral membrane protein TerC family
BC8716_RS19070	COG1120	ATPase activity
BC8716_RS19075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC8716_RS19080	COG5002	protein histidine kinase activity
BC8716_RS19085	COG0745	RESPONSE REGULATOR receiver
BC8716_RS19090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BC8716_RS19095	COG1333	cytochrome c biogenesis protein
BC8716_RS19100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC8716_RS19105	COG1187	pseudouridine synthase activity
BC8716_RS19110	COG0700	Nucleoside recognition
BC8716_RS19115	COG2715	membrane protein required for spore maturation
BC8716_RS19120	COG1686	Belongs to the peptidase S11 family
BC8716_RS19130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC8716_RS19145	COG2323	membrane
BC8716_RS19160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC8716_RS19165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BC8716_RS19170	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS19180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BC8716_RS19185	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BC8716_RS19190	COG1547	Domain of unknown function (DUF309)
BC8716_RS19195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BC8716_RS19200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC8716_RS19200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC8716_RS19205	COG0307	riboflavin synthase, alpha
BC8716_RS19210	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BC8716_RS19215	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS19220	COG2084	Dehydrogenase
BC8716_RS19225	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BC8716_RS19230	COG2079	MmgE PrpD family protein
BC8716_RS19235	COG0372	Belongs to the citrate synthase family
BC8716_RS19255	COG0583	DNA-binding transcription factor activity
BC8716_RS19260	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BC8716_RS19265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BC8716_RS19270	COG0019	diaminopimelate decarboxylase activity
BC8716_RS19275	COG0697	spore germination
BC8716_RS19290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC8716_RS19310	COG2172	sigma factor antagonist activity
BC8716_RS19320	COG1686	Belongs to the peptidase S11 family
BC8716_RS19330	COG1988	membrane-bound metal-dependent
BC8716_RS19345	COG2814	Major facilitator Superfamily
BC8716_RS19355	COG1764	response to oxidative stress
BC8716_RS19365	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BC8716_RS19370	COG4974	Belongs to the 'phage' integrase family
BC8716_RS19380	COG0735	belongs to the Fur family
BC8716_RS19385	COG1300	Membrane
BC8716_RS19390	COG0494	nUDIX hydrolase
BC8716_RS19400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC8716_RS19405	COG1968	undecaprenyl-diphosphatase activity
BC8716_RS19420	COG0395	ABC-type sugar transport system, permease component
BC8716_RS19425	COG1175	transmembrane transport
BC8716_RS19435	COG2972	Histidine kinase
BC8716_RS19445	COG1850	ribulose-bisphosphate carboxylase activity
BC8716_RS19450	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BC8716_RS19455	COG2190	(PTS) system
BC8716_RS19465	COG1510	regulation of RNA biosynthetic process
BC8716_RS19485	COG0367	asparagine synthase
BC8716_RS19490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BC8716_RS19495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BC8716_RS19500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BC8716_RS19510	COG0527	aspartate kinase activity
BC8716_RS19520	COG0789	Transcriptional regulator
BC8716_RS19525	COG2861	carbohydrate metabolic process
BC8716_RS19540	COG0517	IMP dehydrogenase activity
BC8716_RS19550	COG1728	Protein conserved in bacteria
BC8716_RS19560	COG2195	Cleaves the N-terminal amino acid of tripeptides
BC8716_RS19565	COG0346	lactoylglutathione lyase activity
BC8716_RS19570	COG1376	ErfK ybiS ycfS ynhG family protein
BC8716_RS19575	COG4129	membrane
BC8716_RS19580	COG4191	Histidine kinase
BC8716_RS19595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC8716_RS19600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC8716_RS19605	COG0114	fumarate hydratase activity
BC8716_RS19615	COG1396	sequence-specific DNA binding
BC8716_RS19620	COG1396	sequence-specific DNA binding
BC8716_RS19630	COG2382	esterase
BC8716_RS19635	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BC8716_RS19640	COG2153	protein acetylation
BC8716_RS19645	COG0011	TIGRFAM Protein of
BC8716_RS19655	COG0351	phosphomethylpyrimidine kinase
BC8716_RS19660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC8716_RS19665	COG2022	thiamine diphosphate biosynthetic process
BC8716_RS19675	COG0352	thiamine-phosphate diphosphorylase activity
BC8716_RS19680	COG1027	Aspartate ammonia-lyase
BC8716_RS19685	COG1940	carbohydrate kinase activity
BC8716_RS19705	COG0697	spore germination
BC8716_RS19710	COG0457	Tetratricopeptide repeat
BC8716_RS19710	COG0705	Rhomboid family
BC8716_RS19720	COG1757	Na H antiporter
BC8716_RS19725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BC8716_RS19735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BC8716_RS19740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BC8716_RS19760	COG0768	penicillin binding
BC8716_RS19770	COG0477	Major facilitator Superfamily
BC8716_RS19775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BC8716_RS19805	COG0704	Plays a role in the regulation of phosphate uptake
BC8716_RS19820	COG4086	secreted protein
BC8716_RS19825	COG2814	Major facilitator Superfamily
BC8716_RS19835	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BC8716_RS19840	COG4709	membrane
BC8716_RS19845	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BC8716_RS19855	COG0735	belongs to the Fur family
BC8716_RS19860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC8716_RS19865	COG1121	(ABC) transporter
BC8716_RS19875	COG5002	protein histidine kinase activity
BC8716_RS19885	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BC8716_RS19890	COG0513	Belongs to the DEAD box helicase family
BC8716_RS19900	COG1329	Transcriptional regulator
BC8716_RS19905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BC8716_RS19910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BC8716_RS19915	COG2384	SAM-dependent methyltransferase
BC8716_RS19920	COG2010	Cytochrome c
BC8716_RS19925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BC8716_RS19930	COG0358	DNA primase activity
BC8716_RS19935	COG1671	Belongs to the UPF0178 family
BC8716_RS19940	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BC8716_RS19945	COG0517	IMP dehydrogenase activity
BC8716_RS19950	COG0751	glycine-tRNA ligase activity
BC8716_RS19955	COG0752	glycyl-tRNA synthetase alpha subunit
BC8716_RS19960	COG1381	Involved in DNA repair and RecF pathway recombination
BC8716_RS19970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BC8716_RS19975	COG0295	cytidine deaminase activity
BC8716_RS19980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BC8716_RS19985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BC8716_RS19990	COG1480	7TM receptor with intracellular HD hydrolase
BC8716_RS19995	COG1702	phosphate starvation-inducible protein PhoH
BC8716_RS20015	COG4864	UPF0365 protein
BC8716_RS20020	COG1030	water channel activity
BC8716_RS20025	COG1610	YqeY-like protein
BC8716_RS20030	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BC8716_RS20035	COG1283	sodium-dependent phosphate transmembrane transporter activity
BC8716_RS20040	COG0667	Aldo Keto reductase
BC8716_RS20045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BC8716_RS20050	COG1301	dicarboxylic acid transport
BC8716_RS20055	COG2226	methyltransferase
BC8716_RS20060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BC8716_RS20065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BC8716_RS20070	COG2264	protein methyltransferase activity
BC8716_RS20075	COG0484	heat shock protein binding
BC8716_RS20080	COG0443	Heat shock 70 kDa protein
BC8716_RS20085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BC8716_RS20090	COG1420	regulation of RNA biosynthetic process
BC8716_RS20095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BC8716_RS20100	COG0481	GTPase activity
BC8716_RS20110	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC8716_RS20115	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BC8716_RS20120	COG0268	Binds directly to 16S ribosomal RNA
BC8716_RS20125	COG1466	dna polymerase III delta subunit
BC8716_RS20135	COG0658	competence protein
BC8716_RS20135	COG2333	competence protein COMEC
BC8716_RS20140	COG2131	deaminase
BC8716_RS20145	COG1596	polysaccharide export
BC8716_RS20145	COG1555	photosystem II stabilization
BC8716_RS20150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BC8716_RS20155	COG2226	methyltransferase
BC8716_RS20160	COG2996	Protein conserved in bacteria
BC8716_RS20165	COG0799	negative regulation of ribosome biogenesis
BC8716_RS20170	COG1713	HD superfamily hydrolase involved in NAD metabolism
BC8716_RS20175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BC8716_RS20180	COG1534	Rna-binding protein
BC8716_RS20185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BC8716_RS20190	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BC8716_RS20195	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BC8716_RS20205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BC8716_RS20205	COG2111	Na H antiporter
BC8716_RS20210	COG2111	Na H antiporter
BC8716_RS20215	COG1006	Multisubunit Na H antiporter MnhC subunit
BC8716_RS20220	COG0651	ATP synthesis coupled electron transport
BC8716_RS20225	COG1863	multisubunit Na H antiporter MnhE subunit
BC8716_RS20230	COG2212	antiporter activity
BC8716_RS20235	COG1320	monovalent cation:proton antiporter activity
BC8716_RS20240	COG0776	regulation of translation
BC8716_RS20255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BC8716_RS20260	COG2223	nitrite transmembrane transporter activity
BC8716_RS20265	COG0243	molybdopterin cofactor binding
BC8716_RS20270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BC8716_RS20275	COG2146	nitrite reductase [NAD(P)H] activity
BC8716_RS20280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BC8716_RS20285	COG1587	Uroporphyrinogen-III synthase
BC8716_RS20285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BC8716_RS20300	COG4536	flavin adenine dinucleotide binding
BC8716_RS20310	COG0385	Bile acid
BC8716_RS20320	COG1288	antiporter activity
BC8716_RS20325	COG0095	Lipoate-protein ligase
BC8716_RS20330	COG0494	nUDIX hydrolase
BC8716_RS20335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BC8716_RS20340	COG0366	Alpha amylase catalytic
BC8716_RS20345	COG1309	transcriptional regulator
BC8716_RS20355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC8716_RS20360	COG0444	Belongs to the ABC transporter superfamily
BC8716_RS20365	COG4608	Belongs to the ABC transporter superfamily
BC8716_RS20370	COG0747	negative chemotaxis
BC8716_RS20385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BC8716_RS20390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BC8716_RS20395	COG3285	dna ligase
BC8716_RS20395	COG1793	dna ligase
BC8716_RS20405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BC8716_RS20410	COG0572	uridine kinase
BC8716_RS20415	COG4122	O-methyltransferase activity
BC8716_RS20420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BC8716_RS20425	COG3906	Belongs to the UPF0473 family
BC8716_RS20430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BC8716_RS20435	COG4472	Bacterial protein of unknown function (DUF965)
BC8716_RS20440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BC8716_RS20445	COG0628	permease
BC8716_RS20460	COG3881	PFAM PRC-barrel domain
BC8716_RS20465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BC8716_RS20475	COG0482	sulfurtransferase activity
BC8716_RS20480	COG1104	cysteine desulfurase activity
BC8716_RS20485	COG1959	2 iron, 2 sulfur cluster binding
BC8716_RS20490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BC8716_RS20500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BC8716_RS20505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BC8716_RS20525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BC8716_RS20530	COG0124	histidyl-tRNA synthetase
BC8716_RS20535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC8716_RS20540	COG0673	inositol 2-dehydrogenase activity
BC8716_RS20550	COG1609	Transcriptional regulator
BC8716_RS20555	COG2826	transposase and inactivated derivatives, IS30 family
BC8716_RS20560	COG1490	D-aminoacyl-tRNA deacylase activity
BC8716_RS20565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BC8716_RS20570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC8716_RS20575	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BC8716_RS20575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BC8716_RS20580	COG5416	Lipopolysaccharide assembly protein A domain
BC8716_RS20585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BC8716_RS20585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BC8716_RS20590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BC8716_RS20590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BC8716_RS20600	COG2244	polysaccharide biosynthetic process
BC8716_RS20620	COG1862	Preprotein translocase
BC8716_RS20625	COG0343	queuine tRNA-ribosyltransferase activity
BC8716_RS20630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BC8716_RS20640	COG2255	four-way junction helicase activity
BC8716_RS20645	COG0632	four-way junction helicase activity
BC8716_RS20665	COG1388	LysM domain
BC8716_RS20670	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BC8716_RS20675	COG0157	Belongs to the NadC ModD family
BC8716_RS20680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BC8716_RS20685	COG1104	cysteine desulfurase activity
BC8716_RS20690	COG1827	regulation of RNA biosynthetic process
BC8716_RS20695	COG0077	Prephenate dehydratase
BC8716_RS20700	COG4492	Belongs to the UPF0735 family
BC8716_RS20705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BC8716_RS20710	COG3290	protein histidine kinase activity
BC8716_RS20720	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BC8716_RS20725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BC8716_RS20730	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BC8716_RS20735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC8716_RS20740	COG0785	Cytochrome C biogenesis protein
BC8716_RS20750	COG4473	ABC transporter
BC8716_RS20755	COG1131	(ABC) transporter
BC8716_RS20760	COG0537	adenosine 5'-monophosphoramidase activity
BC8716_RS20765	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BC8716_RS20775	COG1846	Transcriptional regulator
BC8716_RS20790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC8716_RS20800	COG3481	metal-dependent phosphohydrolase, HD sub domain
BC8716_RS20805	COG2770	Histidine kinase
BC8716_RS20805	COG2205	protein histidine kinase activity
BC8716_RS20810	COG0745	RESPONSE REGULATOR receiver
BC8716_RS20825	COG0561	phosphatase activity
BC8716_RS20830	COG3679	Belongs to the UPF0342 family
BC8716_RS20835	COG4399	Belongs to the UPF0754 family
BC8716_RS20845	COG2508	Transcriptional regulator
BC8716_RS20850	COG3842	ATPase activity
BC8716_RS20875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BC8716_RS20880	COG1024	Enoyl-CoA hydratase
BC8716_RS20885	COG0511	ligase activity, forming carbon-carbon bonds
BC8716_RS20890	COG0439	Biotin carboxylase
BC8716_RS20895	COG1960	acyl-CoA dehydrogenase activity
BC8716_RS20900	COG1704	LemA family
BC8716_RS20915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC8716_RS20920	COG1132	(ABC) transporter
BC8716_RS20925	COG1132	(ABC) transporter
BC8716_RS20930	COG2719	SpoVR family
BC8716_RS20935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC8716_RS20940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BC8716_RS20945	COG1489	DNA binding
BC8716_RS20950	COG3153	acetyltransferase
BC8716_RS20950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC8716_RS20960	COG0584	glycerophosphoryl diester phosphodiesterase
BC8716_RS20965	COG0179	Fumarylacetoacetate (FAA) hydrolase
BC8716_RS20970	COG0436	Aminotransferase
BC8716_RS20975	COG0778	Nitroreductase
BC8716_RS20980	COG0363	glucosamine-6-phosphate deaminase activity
BC8716_RS20985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BC8716_RS20990	COG2188	Transcriptional regulator
BC8716_RS20995	COG0165	Argininosuccinate lyase
BC8716_RS21000	COG2188	Transcriptional regulator
BC8716_RS21010	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS21040	COG2814	Major facilitator Superfamily
BC8716_RS21055	COG2718	Belongs to the UPF0229 family
BC8716_RS21080	COG2766	serine protein kinase
BC8716_RS21085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC8716_RS21100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BC8716_RS21115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BC8716_RS21130	COG0783	Belongs to the Dps family
BC8716_RS21135	COG1363	Peptidase, m42
BC8716_RS21145	COG1131	(ABC) transporter
BC8716_RS21150	COG1725	Transcriptional regulator
BC8716_RS21160	COG1131	(ABC) transporter
BC8716_RS21170	COG2207	Transcriptional regulator
BC8716_RS21170	COG1917	Cupin 2, conserved barrel domain protein
BC8716_RS21175	COG1621	beta-fructofuranosidase activity
BC8716_RS21185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS21185	COG1263	PTS System
BC8716_RS21195	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS21205	COG1966	Carbon starvation protein
BC8716_RS21220	COG3012	SEC-C Motif Domain Protein
BC8716_RS21220	COG1405	negative regulation of cell septum assembly
BC8716_RS21230	COG0737	Belongs to the 5'-nucleotidase family
BC8716_RS21240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC8716_RS21255	COG0584	glycerophosphoryl diester phosphodiesterase
BC8716_RS21265	COG4894	glucomannan catabolic process
BC8716_RS21270	COG1442	glycosyl transferase family 8
BC8716_RS21285	COG1131	(ABC) transporter
BC8716_RS21290	COG2197	response regulator
BC8716_RS21295	COG4585	Histidine kinase
BC8716_RS21300	COG0406	alpha-ribazole phosphatase activity
BC8716_RS21315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BC8716_RS21330	COG1733	regulation of RNA biosynthetic process
BC8716_RS21340	COG0789	Transcriptional regulator
BC8716_RS21355	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BC8716_RS21365	COG2267	carboxylic ester hydrolase activity
BC8716_RS21380	COG1621	beta-fructofuranosidase activity
BC8716_RS21385	COG1263	PTS System
BC8716_RS21385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS21430	COG3964	amidohydrolase
BC8716_RS21460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC8716_RS21465	COG0789	Transcriptional regulator
BC8716_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS21500	COG2814	Major facilitator Superfamily
BC8716_RS21505	COG0640	Transcriptional regulator
BC8716_RS21515	COG5434	Belongs to the glycosyl hydrolase 28 family
BC8716_RS21620	COG0735	belongs to the Fur family
BC8716_RS21630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BC8716_RS21635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BC8716_RS21640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BC8716_RS21645	COG4129	membrane
BC8716_RS21650	COG1132	(ABC) transporter
BC8716_RS21655	COG3557	Belongs to the UPF0374 family
BC8716_RS21665	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS21680	COG1028	Short-chain dehydrogenase reductase Sdr
BC8716_RS21690	COG1988	membrane-bound metal-dependent
BC8716_RS21710	COG2137	regulation of response to DNA damage stimulus
BC8716_RS21715	COG1090	epimerase
BC8716_RS21725	COG1619	proteins homologs of microcin C7 resistance protein MccF
BC8716_RS21730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC8716_RS21755	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BC8716_RS21770	COG0445	tRNA wobble uridine modification
BC8716_RS21780	COG0726	polysaccharide deacetylase
BC8716_RS21790	COG1253	flavin adenine dinucleotide binding
BC8716_RS21800	COG0535	radical SAM domain protein
BC8716_RS21820	COG1271	oxidase subunit
BC8716_RS21825	COG1294	oxidase, subunit
BC8716_RS21835	COG1164	Oligoendopeptidase f
BC8716_RS21840	COG0753	catalase activity
BC8716_RS21850	COG1012	belongs to the aldehyde dehydrogenase family
BC8716_RS21855	COG0328	RNA-DNA hybrid ribonuclease activity
BC8716_RS21855	COG3341	Caulimovirus viroplasmin
BC8716_RS21865	COG2002	toxin-antitoxin pair type II binding
BC8716_RS21875	COG0733	neurotransmitter:sodium symporter activity
BC8716_RS21885	COG1077	Cell shape determining protein MreB Mrl
BC8716_RS21890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC8716_RS21890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS21890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC8716_RS21895	COG1105	Belongs to the carbohydrate kinase PfkB family
BC8716_RS21900	COG1349	DNA-binding transcription factor activity
BC8716_RS21905	COG0488	(ABC) transporter
BC8716_RS21910	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BC8716_RS21920	COG2188	Transcriptional regulator
BC8716_RS21925	COG0366	Alpha amylase catalytic
BC8716_RS21930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC8716_RS21930	COG1263	PTS System
BC8716_RS21940	COG1649	PFAM Uncharacterised BCR, COG1649
BC8716_RS21945	COG2244	polysaccharide biosynthetic process
BC8716_RS21950	COG1115	amino acid carrier protein
BC8716_RS21955	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BC8716_RS21960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BC8716_RS21975	COG1132	(ABC) transporter
BC8716_RS21980	COG1132	(ABC) transporter
BC8716_RS21985	COG3973	AAA domain
BC8716_RS21995	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BC8716_RS22000	COG3639	organic phosphonate transmembrane transporter activity
BC8716_RS22005	COG3639	organic phosphonate transmembrane transporter activity
BC8716_RS22010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BC8716_RS22035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC8716_RS22040	COG0601	transmembrane transport
BC8716_RS22045	COG0747	negative chemotaxis
BC8716_RS22050	COG4608	Belongs to the ABC transporter superfamily
BC8716_RS22055	COG0444	Belongs to the ABC transporter superfamily
BC8716_RS22065	COG2391	methyltransferase activity
BC8716_RS22075	COG4120	Belongs to the binding-protein-dependent transport system permease family
BC8716_RS22080	COG1116	anion transmembrane transporter activity
BC8716_RS22095	COG4208	sulfate ABC transporter
BC8716_RS22105	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BC8716_RS22110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BC8716_RS22115	COG5002	protein histidine kinase activity
BC8716_RS22120	COG0277	FAD linked oxidase domain protein
BC8716_RS22125	COG0385	Bile acid
BC8716_RS22130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BC8716_RS22150	COG1396	sequence-specific DNA binding
BC8716_RS22170	COG1175	transmembrane transport