locus-tag	class	description
BIZ35_RS00010	COG2079	MmgE PrpD family protein
BIZ35_RS00015	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BIZ35_RS00025	COG0154	amidase activity
BIZ35_RS00035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIZ35_RS00040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIZ35_RS00045	COG1116	anion transmembrane transporter activity
BIZ35_RS00050	COG0083	homoserine kinase activity
BIZ35_RS00055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BIZ35_RS00060	COG0460	homoserine dehydrogenase
BIZ35_RS00065	COG0010	Belongs to the arginase family
BIZ35_RS00075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BIZ35_RS00080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIZ35_RS00090	COG4145	pantothenate transmembrane transporter activity
BIZ35_RS00125	COG1388	LysM domain
BIZ35_RS00125	COG0791	NLP P60 protein
BIZ35_RS00130	COG0024	Methionine aminopeptidase
BIZ35_RS00135	COG1268	BioY protein
BIZ35_RS00150	COG1960	acyl-CoA dehydrogenase activity
BIZ35_RS00155	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS00160	COG2746	aminoglycoside 3-N-acetyltransferase activity
BIZ35_RS00165	COG2244	polysaccharide biosynthetic process
BIZ35_RS00170	COG0589	response to stress
BIZ35_RS00185	COG0535	radical SAM domain protein
BIZ35_RS00195	COG0457	Tetratricopeptide repeat
BIZ35_RS00215	COG1609	Transcriptional regulator
BIZ35_RS00225	COG0561	phosphatase activity
BIZ35_RS00260	COG0656	L-ascorbic acid biosynthetic process
BIZ35_RS00265	COG0431	NADPH-dependent FMN reductase
BIZ35_RS00270	COG0420	3'-5' exonuclease activity
BIZ35_RS00275	COG4717	serine-type aminopeptidase activity
BIZ35_RS00280	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIZ35_RS00285	COG0534	Mate efflux family protein
BIZ35_RS00300	COG1664	Polymer-forming cytoskeletal
BIZ35_RS00310	COG0789	Transcriptional regulator
BIZ35_RS00315	COG0436	Aminotransferase
BIZ35_RS00320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BIZ35_RS00340	COG2226	methyltransferase
BIZ35_RS00355	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BIZ35_RS00390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BIZ35_RS00395	COG1113	amino acid transport
BIZ35_RS00400	COG2814	Major facilitator Superfamily
BIZ35_RS00415	COG2409	Drug exporters of the RND superfamily
BIZ35_RS00415	COG1033	growth of symbiont in host cell
BIZ35_RS00425	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BIZ35_RS00440	COG1960	acyl-CoA dehydrogenase activity
BIZ35_RS00455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIZ35_RS00460	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BIZ35_RS00475	COG1609	Transcriptional regulator
BIZ35_RS00490	COG2996	Protein conserved in bacteria
BIZ35_RS00495	COG0346	lactoylglutathione lyase activity
BIZ35_RS00500	COG1482	cell wall glycoprotein biosynthetic process
BIZ35_RS00510	COG0477	Major facilitator Superfamily
BIZ35_RS00515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BIZ35_RS00525	COG2188	Transcriptional regulator
BIZ35_RS00530	COG0791	NLP P60 protein
BIZ35_RS00530	COG1388	LysM domain
BIZ35_RS00540	COG0768	penicillin binding
BIZ35_RS00545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIZ35_RS00550	COG1739	Uncharacterized protein family UPF0029
BIZ35_RS00560	COG2197	response regulator
BIZ35_RS00570	COG0531	amino acid
BIZ35_RS00575	COG1307	EDD domain protein, DegV family
BIZ35_RS00580	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BIZ35_RS00585	COG1040	competence protein
BIZ35_RS00595	COG2747	anti-sigma28 factor FlgM
BIZ35_RS00605	COG1256	bacterial-type flagellum assembly
BIZ35_RS00605	COG4786	Flagellar basal body rod
BIZ35_RS00610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BIZ35_RS00620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BIZ35_RS00640	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BIZ35_RS00645	COG1285	pathogenesis
BIZ35_RS00650	COG0647	UMP catabolic process
BIZ35_RS00660	COG2271	Major facilitator Superfamily
BIZ35_RS00665	COG1113	amino acid transport
BIZ35_RS00675	COG1113	amino acid transport
BIZ35_RS00690	COG1067	ATP-dependent peptidase activity
BIZ35_RS00700	COG2094	Belongs to the DNA glycosylase MPG family
BIZ35_RS00715	COG1334	flagellar protein FlaG
BIZ35_RS00720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BIZ35_RS00725	COG1516	flagellar protein fliS
BIZ35_RS00745	COG0653	protein targeting
BIZ35_RS00750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BIZ35_RS00755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIZ35_RS00765	COG2884	Cell division ATP-binding protein ftsE
BIZ35_RS00770	COG2177	Part of the ABC transporter FtsEX involved in
BIZ35_RS00775	COG0739	heme binding
BIZ35_RS00790	COG0460	homoserine dehydrogenase
BIZ35_RS00795	COG0793	Belongs to the peptidase S41A family
BIZ35_RS00795	COG3409	Peptidoglycan-binding domain 1 protein
BIZ35_RS00805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIZ35_RS00810	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIZ35_RS00815	COG4605	iron ion homeostasis
BIZ35_RS00820	COG4604	ABC transporter, ATP-binding protein
BIZ35_RS00825	COG4607	ABC-type enterochelin transport system periplasmic component
BIZ35_RS00840	COG0745	RESPONSE REGULATOR receiver
BIZ35_RS00845	COG5002	protein histidine kinase activity
BIZ35_RS00850	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BIZ35_RS00865	COG0573	inorganic phosphate transmembrane transporter activity
BIZ35_RS00870	COG0581	inorganic phosphate transmembrane transporter activity
BIZ35_RS00880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BIZ35_RS00925	COG0556	nucleotide-excision repair
BIZ35_RS00930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIZ35_RS00935	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BIZ35_RS00945	COG0463	Glycosyl transferase, family 2
BIZ35_RS00955	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIZ35_RS00960	COG0463	Glycosyl transferase, family 2
BIZ35_RS00960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIZ35_RS00965	COG1682	transport, permease protein
BIZ35_RS00970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIZ35_RS00975	COG3595	metallopeptidase activity
BIZ35_RS00985	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BIZ35_RS00990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BIZ35_RS00995	COG0546	phosphoglycolate phosphatase activity
BIZ35_RS01000	COG0110	maltose O-acetyltransferase activity
BIZ35_RS01005	COG0457	Tetratricopeptide repeat
BIZ35_RS01010	COG0492	ferredoxin-NADP+ reductase activity
BIZ35_RS01020	COG1051	belongs to the nudix hydrolase family
BIZ35_RS01025	COG1660	Displays ATPase and GTPase activities
BIZ35_RS01030	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BIZ35_RS01035	COG1481	regulation of sporulation
BIZ35_RS01040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_RS01075	COG3842	ATPase activity
BIZ35_RS01080	COG2508	Transcriptional regulator
BIZ35_RS01090	COG0189	ligase activity
BIZ35_RS01095	COG0189	ligase activity
BIZ35_RS01110	COG4399	Belongs to the UPF0754 family
BIZ35_RS01120	COG0561	phosphatase activity
BIZ35_RS01125	COG1024	Enoyl-CoA hydratase
BIZ35_RS01135	COG0861	Integral membrane protein TerC family
BIZ35_RS01140	COG0701	Predicted permease
BIZ35_RS01145	COG3689	TIGRFAM TIGR03943 family protein
BIZ35_RS01150	COG0420	3'-5' exonuclease activity
BIZ35_RS01155	COG4717	serine-type aminopeptidase activity
BIZ35_RS01160	COG3481	metal-dependent phosphohydrolase, HD sub domain
BIZ35_RS01170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BIZ35_RS01190	COG1846	Transcriptional regulator
BIZ35_RS01210	COG0537	adenosine 5'-monophosphoramidase activity
BIZ35_RS01215	COG1131	(ABC) transporter
BIZ35_RS01220	COG4473	ABC transporter
BIZ35_RS01225	COG1473	amidohydrolase
BIZ35_RS01230	COG3069	C4-dicarboxylate transmembrane transporter activity
BIZ35_RS01235	COG2329	Antibiotic biosynthesis monooxygenase
BIZ35_RS01240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BIZ35_RS01245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BIZ35_RS01250	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BIZ35_RS01255	COG1309	transcriptional regulator
BIZ35_RS01260	COG1511	domain protein
BIZ35_RS01265	COG2190	(PTS) system
BIZ35_RS01265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_RS01265	COG2190	(PTS) system
BIZ35_RS01265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_RS01265	COG1263	PTS System
BIZ35_RS01265	COG1263	PTS System
BIZ35_RS01270	COG1349	DNA-binding transcription factor activity
BIZ35_RS01280	COG0697	spore germination
BIZ35_RS01285	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS01290	COG1999	signal sequence binding
BIZ35_RS01305	COG0095	Lipoate-protein ligase
BIZ35_RS01310	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_RS01320	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BIZ35_RS01330	COG0501	Belongs to the peptidase M48B family
BIZ35_RS01355	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BIZ35_RS01360	COG1074	ATP-dependent DNA helicase activity
BIZ35_RS01395	COG2311	Membrane
BIZ35_RS01400	COG0179	Fumarylacetoacetate (FAA) hydrolase
BIZ35_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS01420	COG1307	EDD domain protein, DegV family
BIZ35_RS01430	COG0561	phosphatase activity
BIZ35_RS01435	COG2151	metal-sulfur cluster biosynthetic enzyme
BIZ35_RS01465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIZ35_RS01470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIZ35_RS01485	COG4608	Belongs to the ABC transporter superfamily
BIZ35_RS01490	COG0601	transmembrane transport
BIZ35_RS01500	COG0747	negative chemotaxis
BIZ35_RS01515	COG0180	Tryptophanyl-tRNA synthetase
BIZ35_RS01530	COG4166	transmembrane transport
BIZ35_RS01535	COG0601	transmembrane transport
BIZ35_RS01540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIZ35_RS01545	COG0444	Belongs to the ABC transporter superfamily
BIZ35_RS01550	COG4608	Belongs to the ABC transporter superfamily
BIZ35_RS01555	COG1393	Belongs to the ArsC family
BIZ35_RS01565	COG4862	establishment of competence for transformation
BIZ35_RS01570	COG4469	Competence protein
BIZ35_RS01575	COG1164	Oligoendopeptidase f
BIZ35_RS01585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BIZ35_RS01590	COG2346	COG2346, Truncated hemoglobins
BIZ35_RS01595	COG0741	lytic transglycosylase activity
BIZ35_RS01600	COG4116	CYTH
BIZ35_RS01610	COG2357	RelA SpoT domain protein
BIZ35_RS01620	COG0564	pseudouridine synthase activity
BIZ35_RS01625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BIZ35_RS01630	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BIZ35_RS01665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIZ35_RS01685	COG2153	protein acetylation
BIZ35_RS01695	COG2382	esterase
BIZ35_RS01710	COG1940	carbohydrate kinase activity
BIZ35_RS01720	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS01725	COG4152	abc transporter atp-binding protein
BIZ35_RS01730	COG1668	transmembrane transport
BIZ35_RS01745	COG3579	cysteine-type endopeptidase activity
BIZ35_RS01810	COG1247	-acetyltransferase
BIZ35_RS01830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIZ35_RS01835	COG2059	Chromate
BIZ35_RS01840	COG2059	Chromate
BIZ35_RS01845	COG1522	sequence-specific DNA binding
BIZ35_RS01855	COG0405	Gamma-glutamyltransferase
BIZ35_RS01860	COG0154	amidase activity
BIZ35_RS01970	COG4974	Belongs to the 'phage' integrase family
BIZ35_RS01985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIZ35_RS01990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIZ35_RS02015	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS02035	COG1959	2 iron, 2 sulfur cluster binding
BIZ35_RS02050	COG0730	response to heat
BIZ35_RS02055	COG0783	Belongs to the Dps family
BIZ35_RS02065	COG0673	inositol 2-dehydrogenase activity
BIZ35_RS02070	COG3852	Histidine kinase
BIZ35_RS02075	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BIZ35_RS02085	COG0861	Integral membrane protein TerC family
BIZ35_RS02095	COG5002	protein histidine kinase activity
BIZ35_RS02100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BIZ35_RS02120	COG0542	response to heat
BIZ35_RS02125	COG3949	Membrane
BIZ35_RS02135	COG4873	Protein conserved in bacteria
BIZ35_RS02150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_RS02170	COG2084	Dehydrogenase
BIZ35_RS02175	COG0436	Aminotransferase
BIZ35_RS02180	COG0784	Response regulator, receiver
BIZ35_RS02180	COG0835	chemotaxis
BIZ35_RS02190	COG2409	Drug exporters of the RND superfamily
BIZ35_RS02190	COG1033	growth of symbiont in host cell
BIZ35_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS02220	COG4703	Protein of unknown function (DUF1797)
BIZ35_RS02225	COG0517	IMP dehydrogenase activity
BIZ35_RS02230	COG0583	DNA-binding transcription factor activity
BIZ35_RS02235	COG2171	N-acyltransferase activity
BIZ35_RS02240	COG1473	amidohydrolase
BIZ35_RS02250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIZ35_RS02290	COG1982	Orn Lys Arg decarboxylase major
BIZ35_RS02295	COG4476	Belongs to the UPF0223 family
BIZ35_RS02310	COG0483	inositol monophosphate 1-phosphatase activity
BIZ35_RS02320	COG1217	gtp-binding protein TYPA
BIZ35_RS02330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BIZ35_RS02335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BIZ35_RS02340	COG4838	Belongs to the UPF0358 family
BIZ35_RS02345	COG0772	Belongs to the SEDS family
BIZ35_RS02350	COG1612	heme a metabolic process
BIZ35_RS02355	COG0109	protoheme IX farnesyltransferase activity
BIZ35_RS02375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BIZ35_RS02380	COG3336	cytochrome c oxidase
BIZ35_RS02390	COG2340	Cysteine-rich secretory protein family
BIZ35_RS02395	COG2050	protein possibly involved in aromatic compounds catabolism
BIZ35_RS02415	COG3679	Belongs to the UPF0342 family
BIZ35_RS02420	COG4471	UPF0298 protein
BIZ35_RS02430	COG0742	ribosomal rna small subunit methyltransferase
BIZ35_RS02435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BIZ35_RS02440	COG3314	Sporulation integral membrane protein YlbJ
BIZ35_RS02445	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIZ35_RS02450	COG3480	Lon protease (S16) C-terminal proteolytic domain
BIZ35_RS02455	COG1323	Belongs to the UPF0348 family
BIZ35_RS02460	COG1399	metal-binding, possibly nucleic acid-binding protein
BIZ35_RS02465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BIZ35_RS02475	COG0454	-acetyltransferase
BIZ35_RS02480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIZ35_RS02485	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BIZ35_RS02490	COG2001	Belongs to the MraZ family
BIZ35_RS02495	COG0275	rRNA processing
BIZ35_RS02500	COG4839	cell division protein FtsL
BIZ35_RS02505	COG0768	penicillin binding
BIZ35_RS02510	COG0768	penicillin binding
BIZ35_RS02525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIZ35_RS02530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BIZ35_RS02535	COG0772	Belongs to the SEDS family
BIZ35_RS02540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIZ35_RS02545	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BIZ35_RS02550	COG3328	transposase activity
BIZ35_RS02555	COG0849	cell division
BIZ35_RS02560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BIZ35_RS02570	COG1191	sigma factor activity
BIZ35_RS02575	COG1191	sigma factor activity
BIZ35_RS02580	COG1873	PFAM PRC-barrel domain
BIZ35_RS02585	COG1388	LysM domain
BIZ35_RS02585	COG3584	3D domain protein
BIZ35_RS02595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BIZ35_RS02600	COG1799	cell septum assembly
BIZ35_RS02605	COG0762	integral membrane protein
BIZ35_RS02610	COG2302	S4 RNA-binding domain
BIZ35_RS02615	COG3599	regulation of cell shape
BIZ35_RS02640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BIZ35_RS02645	COG0564	pseudouridine synthase activity
BIZ35_RS02650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BIZ35_RS02655	COG0540	Belongs to the ATCase OTCase family
BIZ35_RS02660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BIZ35_RS02675	COG0543	2 iron, 2 sulfur cluster binding
BIZ35_RS02680	COG0167	dihydroorotate dehydrogenase activity
BIZ35_RS02685	COG0284	orotidine-5'-phosphate decarboxylase activity
BIZ35_RS02690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BIZ35_RS02705	COG2207	Transcriptional regulator
BIZ35_RS02705	COG1917	Cupin 2, conserved barrel domain protein
BIZ35_RS02710	COG1070	Carbohydrate kinase
BIZ35_RS02715	COG4806	L-rhamnose isomerase
BIZ35_RS02720	COG0235	Class ii aldolase
BIZ35_RS02725	COG1454	alcohol dehydrogenase
BIZ35_RS02730	COG1803	Methylglyoxal synthase
BIZ35_RS02735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BIZ35_RS02740	COG0477	Major facilitator Superfamily
BIZ35_RS02745	COG0477	Major facilitator Superfamily
BIZ35_RS02750	COG1309	transcriptional regulator
BIZ35_RS02760	COG0628	permease
BIZ35_RS02765	COG0561	phosphatase activity
BIZ35_RS02785	COG0720	synthase
BIZ35_RS02795	COG0385	Bile acid
BIZ35_RS02810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BIZ35_RS02815	COG1561	YicC-like family, N-terminal region
BIZ35_RS02820	COG2052	Domain of unknown function (DUF370)
BIZ35_RS02825	COG0194	GDP metabolic process
BIZ35_RS02830	COG1758	RNA polymerase activity
BIZ35_RS02835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BIZ35_RS02840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BIZ35_RS02845	COG0242	peptide deformylase activity
BIZ35_RS02850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BIZ35_RS02855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BIZ35_RS02855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIZ35_RS02860	COG0631	protein serine/threonine phosphatase activity
BIZ35_RS02865	COG2815	serine threonine protein kinase
BIZ35_RS02865	COG0515	serine threonine protein kinase
BIZ35_RS02875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BIZ35_RS02880	COG1564	THIamine pyrophosphokinase
BIZ35_RS02890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BIZ35_RS02900	COG1302	Protein conserved in bacteria
BIZ35_RS02905	COG1461	Dihydroxyacetone kinase
BIZ35_RS02910	COG1760	l-serine dehydratase
BIZ35_RS02915	COG1760	l-serine dehydratase
BIZ35_RS02920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BIZ35_RS02925	COG1349	DNA-binding transcription factor activity
BIZ35_RS02930	COG0416	fatty acid biosynthetic process
BIZ35_RS02935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BIZ35_RS02940	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS02950	COG0571	ribonuclease III activity
BIZ35_RS02955	COG1196	nuclear chromosome segregation
BIZ35_RS02960	COG0552	protein localization to endoplasmic reticulum
BIZ35_RS02965	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BIZ35_RS02970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BIZ35_RS02980	COG1837	Belongs to the UPF0109 family
BIZ35_RS02990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BIZ35_RS02995	COG0336	Belongs to the RNA methyltransferase TrmD family
BIZ35_RS03010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BIZ35_RS03025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIZ35_RS03030	COG0045	succinate-CoA ligase (ADP-forming) activity
BIZ35_RS03035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BIZ35_RS03040	COG0758	DNA mediated transformation
BIZ35_RS03045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIZ35_RS03055	COG4974	Belongs to the 'phage' integrase family
BIZ35_RS03060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BIZ35_RS03070	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BIZ35_RS03075	COG1815	bacterial-type flagellum-dependent cell motility
BIZ35_RS03080	COG1558	bacterial-type flagellum-dependent cell motility
BIZ35_RS03085	COG1677	Flagellar hook-basal body complex protein FliE
BIZ35_RS03090	COG1766	The M ring may be actively involved in energy transduction
BIZ35_RS03095	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIZ35_RS03100	COG1317	bacterial-type flagellum organization
BIZ35_RS03105	COG1157	protein secretion by the type III secretion system
BIZ35_RS03110	COG2882	bacterial-type flagellum organization
BIZ35_RS03125	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BIZ35_RS03135	COG4786	Flagellar basal body rod
BIZ35_RS03145	COG1580	Controls the rotational direction of flagella during chemotaxis
BIZ35_RS03150	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIZ35_RS03155	COG1776	CheC inhibitor of MCP methylation
BIZ35_RS03155	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIZ35_RS03160	COG2201	protein-glutamate methylesterase activity
BIZ35_RS03165	COG3190	flagellar
BIZ35_RS03170	COG1338	Plays a role in the flagellum-specific transport system
BIZ35_RS03175	COG1987	bacterial-type flagellum assembly
BIZ35_RS03180	COG1684	flagellar biosynthetic protein fliR
BIZ35_RS03185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIZ35_RS03190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIZ35_RS03195	COG1419	protein localization to endoplasmic reticulum
BIZ35_RS03200	COG0455	bacterial-type flagellum organization
BIZ35_RS03205	COG2201	protein-glutamate methylesterase activity
BIZ35_RS03210	COG0643	Histidine kinase
BIZ35_RS03210	COG2198	Histidine kinase
BIZ35_RS03215	COG0835	chemotaxis
BIZ35_RS03220	COG1776	CheC inhibitor of MCP methylation
BIZ35_RS03225	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BIZ35_RS03230	COG1191	sigma factor activity
BIZ35_RS03240	COG0052	Belongs to the universal ribosomal protein uS2 family
BIZ35_RS03245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BIZ35_RS03250	COG0528	UMP kinase activity
BIZ35_RS03255	COG0233	cytoplasmic translational termination
BIZ35_RS03265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BIZ35_RS03270	COG4589	Belongs to the CDS family
BIZ35_RS03280	COG0750	zinc metalloprotease
BIZ35_RS03285	COG0442	prolyl-tRNA aminoacylation
BIZ35_RS03290	COG2176	DNA-directed DNA polymerase activity
BIZ35_RS03295	COG0779	Required for maturation of 30S ribosomal subunits
BIZ35_RS03300	COG0195	Participates in both transcription termination and antitermination
BIZ35_RS03305	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BIZ35_RS03310	COG1358	cellular component organization or biogenesis
BIZ35_RS03320	COG1550	Protein conserved in bacteria
BIZ35_RS03325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BIZ35_RS03330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BIZ35_RS03335	COG0196	riboflavin kinase activity
BIZ35_RS03340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BIZ35_RS03345	COG1185	polyribonucleotide nucleotidyltransferase activity
BIZ35_RS03350	COG0726	polysaccharide deacetylase
BIZ35_RS03355	COG0612	Peptidase, M16
BIZ35_RS03360	COG1873	PFAM PRC-barrel domain
BIZ35_RS03365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIZ35_RS03370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BIZ35_RS03375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BIZ35_RS03385	COG0527	aspartate kinase activity
BIZ35_RS03400	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIZ35_RS03405	COG0740	serine-type endopeptidase activity
BIZ35_RS03415	COG1674	ftsk spoiiie
BIZ35_RS03415	COG4980	gas vesicle protein
BIZ35_RS03420	COG1744	ABC transporter substrate-binding protein PnrA-like
BIZ35_RS03425	COG3845	ABC transporter
BIZ35_RS03430	COG4603	Belongs to the binding-protein-dependent transport system permease family
BIZ35_RS03435	COG1079	Belongs to the binding-protein-dependent transport system permease family
BIZ35_RS03440	COG0612	Peptidase, M16
BIZ35_RS03445	COG0612	Peptidase, M16
BIZ35_RS03450	COG0300	oxidoreductase activity
BIZ35_RS03465	COG1426	Protein conserved in bacteria
BIZ35_RS03470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIZ35_RS03475	COG1058	Belongs to the CinA family
BIZ35_RS03475	COG1546	Belongs to the CinA family
BIZ35_RS03490	COG1418	mRNA catabolic process
BIZ35_RS03495	COG1692	metallophosphoesterase
BIZ35_RS03500	COG2359	stage V sporulation protein S
BIZ35_RS03505	COG0826	peptidase U32
BIZ35_RS03510	COG0826	peptidase U32
BIZ35_RS03520	COG3829	transcription factor binding
BIZ35_RS03525	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS03535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BIZ35_RS03540	COG4550	Control of competence regulator ComK, YlbF/YmcA
BIZ35_RS03550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BIZ35_RS03555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BIZ35_RS03585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BIZ35_RS03600	COG0464	growth
BIZ35_RS03605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BIZ35_RS03610	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BIZ35_RS03615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIZ35_RS03635	COG1321	iron dependent repressor
BIZ35_RS03645	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BIZ35_RS03655	COG1418	mRNA catabolic process
BIZ35_RS03660	COG0488	(ABC) transporter
BIZ35_RS03665	COG1413	lyase activity
BIZ35_RS03685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BIZ35_RS03690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIZ35_RS03695	COG1272	protein, Hemolysin III
BIZ35_RS03700	COG2755	lipolytic protein G-D-S-L family
BIZ35_RS03710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BIZ35_RS03710	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BIZ35_RS03715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ35_RS03720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ35_RS03730	COG0840	transmembrane signaling receptor activity
BIZ35_RS03735	COG4479	Belongs to the UPF0346 family
BIZ35_RS03755	COG1876	peptidase activity
BIZ35_RS03760	COG3409	Peptidoglycan-binding domain 1 protein
BIZ35_RS03760	COG0793	Belongs to the peptidase S41A family
BIZ35_RS03765	COG1846	Transcriptional regulator
BIZ35_RS03770	COG2340	Cysteine-rich secretory protein family
BIZ35_RS03775	COG0534	Mate efflux family protein
BIZ35_RS03790	COG3285	dna ligase
BIZ35_RS03790	COG1793	dna ligase
BIZ35_RS03795	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BIZ35_RS03800	COG0671	phosphoesterase, PA-phosphatase related
BIZ35_RS03805	COG1368	sulfuric ester hydrolase activity
BIZ35_RS03820	COG1331	Highly conserved protein containing a thioredoxin domain
BIZ35_RS03825	COG2814	Major facilitator Superfamily
BIZ35_RS03835	COG0745	RESPONSE REGULATOR receiver
BIZ35_RS03840	COG5002	protein histidine kinase activity
BIZ35_RS03850	COG0567	Dehydrogenase, E1 component
BIZ35_RS03855	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIZ35_RS03860	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS03880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIZ35_RS03890	COG1054	Belongs to the UPF0176 family
BIZ35_RS03900	COG2135	peptidase activity
BIZ35_RS03910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIZ35_RS03915	COG0516	GMP reductase activity
BIZ35_RS03915	COG0517	IMP dehydrogenase activity
BIZ35_RS03920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIZ35_RS03920	COG0723	plastoquinol--plastocyanin reductase activity
BIZ35_RS03925	COG1388	LysM domain
BIZ35_RS03925	COG3584	3D domain protein
BIZ35_RS03930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIZ35_RS03935	COG1113	amino acid transport
BIZ35_RS03940	COG1280	lysine exporter protein (LysE YggA)
BIZ35_RS03945	COG0598	Magnesium transport protein CorA
BIZ35_RS03960	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BIZ35_RS03965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BIZ35_RS03970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BIZ35_RS03975	COG0131	Imidazoleglycerol-phosphate dehydratase
BIZ35_RS03980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BIZ35_RS03990	COG0107	imidazoleglycerol-phosphate synthase activity
BIZ35_RS03995	COG0140	phosphoribosyl-ATP diphosphatase activity
BIZ35_RS03995	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BIZ35_RS04005	COG2391	methyltransferase activity
BIZ35_RS04010	COG2962	Rard protein
BIZ35_RS04015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BIZ35_RS04020	COG0569	domain protein
BIZ35_RS04040	COG2807	transmembrane transport
BIZ35_RS04045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BIZ35_RS04055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ35_RS04065	COG1278	Cold shock
BIZ35_RS04070	COG0302	gtp cyclohydrolase
BIZ35_RS04075	COG3634	alkyl hydroperoxide reductase activity
BIZ35_RS04090	COG0577	efflux transmembrane transporter activity
BIZ35_RS04095	COG1136	(ABC) transporter
BIZ35_RS04100	COG0642	Histidine kinase
BIZ35_RS04105	COG0745	RESPONSE REGULATOR receiver
BIZ35_RS04130	COG0640	Transcriptional regulator
BIZ35_RS04135	COG2814	Major facilitator Superfamily
BIZ35_RS04140	COG5039	Polysaccharide pyruvyl transferase
BIZ35_RS04145	COG1113	amino acid transport
BIZ35_RS04165	COG0477	Major facilitator Superfamily
BIZ35_RS04175	COG1132	(ABC) transporter
BIZ35_RS04180	COG1132	(ABC) transporter
BIZ35_RS04190	COG1380	Effector of murein hydrolase LrgA
BIZ35_RS04195	COG1346	cytolysis
BIZ35_RS04200	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_RS04225	COG2309	aminopeptidase activity
BIZ35_RS04235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BIZ35_RS04250	COG0824	Thioesterase
BIZ35_RS04260	COG4841	protein insertion into membrane
BIZ35_RS04265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BIZ35_RS04270	COG1832	CoA-binding protein
BIZ35_RS04275	COG0187	DNA topoisomerase II activity
BIZ35_RS04280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIZ35_RS04295	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BIZ35_RS04300	COG0574	Belongs to the PEP-utilizing enzyme family
BIZ35_RS04300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BIZ35_RS04325	COG2070	2-Nitropropane dioxygenase
BIZ35_RS04335	COG0681	Belongs to the peptidase S26 family
BIZ35_RS04345	COG0473	3-isopropylmalate dehydrogenase activity
BIZ35_RS04355	COG2226	methyltransferase
BIZ35_RS04380	COG0456	acetyltransferase
BIZ35_RS04385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIZ35_RS04390	COG0456	acetyltransferase
BIZ35_RS04420	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIZ35_RS04425	COG0351	phosphomethylpyrimidine kinase
BIZ35_RS04430	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS04435	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BIZ35_RS04440	COG0351	phosphomethylpyrimidine kinase
BIZ35_RS04450	COG2258	MOSC domain
BIZ35_RS04485	COG1309	transcriptional regulator
BIZ35_RS04490	COG2814	Major facilitator Superfamily
BIZ35_RS04495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIZ35_RS04500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIZ35_RS04510	COG1809	phosphosulfolactate synthase activity
BIZ35_RS04515	COG2045	Belongs to the ComB family
BIZ35_RS04520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BIZ35_RS04525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BIZ35_RS04535	COG0789	Transcriptional regulator
BIZ35_RS04540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIZ35_RS04545	COG0697	spore germination
BIZ35_RS04550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BIZ35_RS04555	COG0022	dehydrogenase e1 component
BIZ35_RS04560	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIZ35_RS04565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIZ35_RS04570	COG3284	Transcriptional regulator
BIZ35_RS04575	COG3264	Mechanosensitive ion channel
BIZ35_RS04575	COG1511	domain protein
BIZ35_RS04590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ35_RS04595	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BIZ35_RS04610	COG0183	Belongs to the thiolase family
BIZ35_RS04615	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_RS04625	COG0561	phosphatase activity
BIZ35_RS04630	COG2322	membrane
BIZ35_RS04645	COG0039	L-malate dehydrogenase activity
BIZ35_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS04655	COG2223	nitrite transmembrane transporter activity
BIZ35_RS04660	COG3773	Cell wall hydrolase
BIZ35_RS04665	COG0708	Exodeoxyribonuclease III
BIZ35_RS04675	COG0297	glycogen (starch) synthase activity
BIZ35_RS04680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BIZ35_RS04685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BIZ35_RS04690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BIZ35_RS04715	COG1247	-acetyltransferase
BIZ35_RS04720	COG0494	nUDIX hydrolase
BIZ35_RS04725	COG1914	H( )-stimulated, divalent metal cation uptake system
BIZ35_RS04730	COG0783	Belongs to the Dps family
BIZ35_RS04740	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BIZ35_RS04745	COG1131	(ABC) transporter
BIZ35_RS04770	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BIZ35_RS04780	COG2030	dehydratase
BIZ35_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS04800	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BIZ35_RS04805	COG0709	Synthesizes selenophosphate from selenide and ATP
BIZ35_RS04820	COG0701	Predicted permease
BIZ35_RS04825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BIZ35_RS04830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BIZ35_RS04840	COG1252	NADH dehydrogenase
BIZ35_RS04845	COG2404	hydrolase activity, acting on ester bonds
BIZ35_RS04855	COG4990	cell redox homeostasis
BIZ35_RS04860	COG0789	Transcriptional regulator
BIZ35_RS04885	COG0436	Aminotransferase
BIZ35_RS04890	COG0165	Argininosuccinate lyase
BIZ35_RS04895	COG0137	argininosuccinate synthase activity
BIZ35_RS04900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BIZ35_RS04905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BIZ35_RS04910	COG0505	Belongs to the CarA family
BIZ35_RS04915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BIZ35_RS04920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BIZ35_RS04925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BIZ35_RS04930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BIZ35_RS04945	COG3546	catalase activity
BIZ35_RS04965	COG1619	proteins homologs of microcin C7 resistance protein MccF
BIZ35_RS04970	COG2027	D-alanyl-D-alanine carboxypeptidase
BIZ35_RS04975	COG0204	Acyl-transferase
BIZ35_RS04985	COG4846	Membrane protein involved in cytochrome C biogenesis
BIZ35_RS04990	COG2201	protein-glutamate methylesterase activity
BIZ35_RS04995	COG0785	Cytochrome C biogenesis protein
BIZ35_RS05000	COG3763	UPF0154 protein
BIZ35_RS05015	COG4224	UPF0291 protein
BIZ35_RS05020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BIZ35_RS05030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BIZ35_RS05035	COG0174	glutamine synthetase
BIZ35_RS05040	COG0789	Transcriptional regulator
BIZ35_RS05045	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BIZ35_RS05075	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BIZ35_RS05080	COG0116	Belongs to the methyltransferase superfamily
BIZ35_RS05095	COG4474	Belongs to the UPF0398 family
BIZ35_RS05105	COG3359	exonuclease
BIZ35_RS05110	COG1111	helicase
BIZ35_RS05110	COG1205	dead DEAH box helicase
BIZ35_RS05115	COG0071	Belongs to the small heat shock protein (HSP20) family
BIZ35_RS05140	COG3331	DNA recombination
BIZ35_RS05145	COG4499	WXG100 protein secretion system (Wss), protein YukC
BIZ35_RS05145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIZ35_RS05150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BIZ35_RS05155	COG3935	DnaD domain protein
BIZ35_RS05160	COG0017	Asparaginyl-tRNA synthetase
BIZ35_RS05175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BIZ35_RS05175	COG1199	ATP-dependent helicase activity
BIZ35_RS05180	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BIZ35_RS05185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BIZ35_RS05205	COG0438	transferase activity, transferring glycosyl groups
BIZ35_RS05210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BIZ35_RS05215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BIZ35_RS05220	COG1694	Mazg nucleotide pyrophosphohydrolase
BIZ35_RS05225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIZ35_RS05235	COG2738	Putative neutral zinc metallopeptidase
BIZ35_RS05245	COG4347	Protein of unknown function (DUF1405)
BIZ35_RS05255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BIZ35_RS05270	COG5582	Belongs to the UPF0302 family
BIZ35_RS05275	COG0457	Tetratricopeptide repeat
BIZ35_RS05285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BIZ35_RS05290	COG0287	Prephenate dehydrogenase
BIZ35_RS05295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BIZ35_RS05300	COG4401	Chorismate mutase type I
BIZ35_RS05305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BIZ35_RS05310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BIZ35_RS05315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BIZ35_RS05320	COG0105	UTP biosynthetic process
BIZ35_RS05325	COG0142	geranyltranstransferase activity
BIZ35_RS05330	COG2226	methyltransferase
BIZ35_RS05335	COG0142	geranyltranstransferase activity
BIZ35_RS05350	COG0776	regulation of translation
BIZ35_RS05355	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BIZ35_RS05375	COG1160	GTP binding
BIZ35_RS05390	COG0539	negative regulation of cytoplasmic translation
BIZ35_RS05395	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BIZ35_RS05400	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BIZ35_RS05405	COG2959	enzyme of heme biosynthesis
BIZ35_RS05410	COG3409	Peptidoglycan-binding domain 1 protein
BIZ35_RS05410	COG3773	Cell wall hydrolase
BIZ35_RS05415	COG2339	peptidase activity
BIZ35_RS05420	COG0492	ferredoxin-NADP+ reductase activity
BIZ35_RS05425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIZ35_RS05435	COG1408	metallophosphoesterase
BIZ35_RS05450	COG3546	catalase activity
BIZ35_RS05465	COG1266	CAAX protease self-immunity
BIZ35_RS05470	COG0514	ATP-dependent DNA helicase (RecQ)
BIZ35_RS05480	COG1141	Ferredoxin
BIZ35_RS05485	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BIZ35_RS05490	COG0741	lytic transglycosylase activity
BIZ35_RS05490	COG1196	nuclear chromosome segregation
BIZ35_RS05490	COG0739	heme binding
BIZ35_RS05495	COG5002	protein histidine kinase activity
BIZ35_RS05500	COG0745	RESPONSE REGULATOR receiver
BIZ35_RS05505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BIZ35_RS05510	COG1333	cytochrome c biogenesis protein
BIZ35_RS05515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ35_RS05520	COG1187	pseudouridine synthase activity
BIZ35_RS05525	COG0700	Nucleoside recognition
BIZ35_RS05530	COG2715	membrane protein required for spore maturation
BIZ35_RS05535	COG1686	Belongs to the peptidase S11 family
BIZ35_RS05540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BIZ35_RS05560	COG0697	spore germination
BIZ35_RS05580	COG1191	sigma factor activity
BIZ35_RS05595	COG1686	Belongs to the peptidase S11 family
BIZ35_RS05600	COG4974	Belongs to the 'phage' integrase family
BIZ35_RS05610	COG0735	belongs to the Fur family
BIZ35_RS05615	COG1300	Membrane
BIZ35_RS05620	COG1379	DNA repair
BIZ35_RS05635	COG0667	Aldo Keto reductase
BIZ35_RS05650	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BIZ35_RS05655	COG3853	Toxic anion resistance protein (TelA)
BIZ35_RS05660	COG1073	alpha beta
BIZ35_RS05665	COG1388	LysM domain
BIZ35_RS05665	COG3858	chitin binding
BIZ35_RS05675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIZ35_RS05680	COG0300	oxidoreductase activity
BIZ35_RS05690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIZ35_RS05700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BIZ35_RS05705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIZ35_RS05715	COG2195	Cleaves the N-terminal amino acid of tripeptides
BIZ35_RS05725	COG1376	ErfK ybiS ycfS ynhG family protein
BIZ35_RS05735	COG1105	Belongs to the carbohydrate kinase PfkB family
BIZ35_RS05740	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIZ35_RS05745	COG0022	dehydrogenase e1 component
BIZ35_RS05750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BIZ35_RS05755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIZ35_RS05765	COG3829	transcription factor binding
BIZ35_RS05765	COG3290	protein histidine kinase activity
BIZ35_RS05770	COG3829	transcription factor binding
BIZ35_RS05770	COG3290	protein histidine kinase activity
BIZ35_RS05780	COG0584	glycerophosphoryl diester phosphodiesterase
BIZ35_RS05785	COG0745	RESPONSE REGULATOR receiver
BIZ35_RS05795	COG0750	zinc metalloprotease
BIZ35_RS05800	COG0497	DNA recombination
BIZ35_RS05810	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BIZ35_RS05815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIZ35_RS05830	COG1570	exodeoxyribonuclease VII activity
BIZ35_RS05845	COG1302	Protein conserved in bacteria
BIZ35_RS05850	COG0439	Biotin carboxylase
BIZ35_RS05855	COG0511	ligase activity, forming carbon-carbon bonds
BIZ35_RS05895	COG3854	ATPases associated with a variety of cellular activities
BIZ35_RS05900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BIZ35_RS05905	COG0006	proline dipeptidase activity
BIZ35_RS05910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BIZ35_RS05920	COG3872	metal-dependent enzyme
BIZ35_RS05930	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIZ35_RS05940	COG3327	negative regulation of DNA-templated transcription, initiation
BIZ35_RS05945	COG0183	Belongs to the thiolase family
BIZ35_RS05950	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIZ35_RS05955	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS05960	COG1024	Enoyl-CoA hydratase
BIZ35_RS05965	COG0492	ferredoxin-NADP+ reductase activity
BIZ35_RS05975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ35_RS05980	COG0095	Lipoate-protein ligase
BIZ35_RS05985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BIZ35_RS05990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BIZ35_RS06000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BIZ35_RS06005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BIZ35_RS06020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BIZ35_RS06045	COG4537	Required for transformation and DNA binding
BIZ35_RS06050	COG1459	type II secretion system
BIZ35_RS06055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BIZ35_RS06070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIZ35_RS06080	COG1940	carbohydrate kinase activity
BIZ35_RS06085	COG4483	Protein conserved in bacteria
BIZ35_RS06090	COG0705	Rhomboid family
BIZ35_RS06090	COG0457	Tetratricopeptide repeat
BIZ35_RS06095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BIZ35_RS06105	COG0768	penicillin binding
BIZ35_RS06110	COG0477	Major facilitator Superfamily
BIZ35_RS06115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BIZ35_RS06125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BIZ35_RS06130	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BIZ35_RS06135	COG0735	belongs to the Fur family
BIZ35_RS06140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BIZ35_RS06145	COG1121	(ABC) transporter
BIZ35_RS06155	COG0791	NLP P60 protein
BIZ35_RS06155	COG3883	PFAM NLP P60 protein
BIZ35_RS06160	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BIZ35_RS06165	COG0513	Belongs to the DEAD box helicase family
BIZ35_RS06175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BIZ35_RS06180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BIZ35_RS06185	COG2384	SAM-dependent methyltransferase
BIZ35_RS06190	COG2010	Cytochrome c
BIZ35_RS06200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIZ35_RS06205	COG0358	DNA primase activity
BIZ35_RS06215	COG0517	IMP dehydrogenase activity
BIZ35_RS06220	COG1381	Involved in DNA repair and RecF pathway recombination
BIZ35_RS06235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BIZ35_RS06240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BIZ35_RS06245	COG1480	7TM receptor with intracellular HD hydrolase
BIZ35_RS06250	COG1702	phosphate starvation-inducible protein PhoH
BIZ35_RS06265	COG1610	YqeY-like protein
BIZ35_RS06280	COG1283	sodium-dependent phosphate transmembrane transporter activity
BIZ35_RS06285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BIZ35_RS06290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BIZ35_RS06295	COG2264	protein methyltransferase activity
BIZ35_RS06305	COG0443	Heat shock 70 kDa protein
BIZ35_RS06310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BIZ35_RS06320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BIZ35_RS06325	COG0481	GTPase activity
BIZ35_RS06330	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIZ35_RS06335	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BIZ35_RS06340	COG0268	Binds directly to 16S ribosomal RNA
BIZ35_RS06345	COG1466	dna polymerase III delta subunit
BIZ35_RS06350	COG0658	competence protein
BIZ35_RS06350	COG2333	competence protein COMEC
BIZ35_RS06355	COG2131	deaminase
BIZ35_RS06360	COG1555	photosystem II stabilization
BIZ35_RS06360	COG1596	polysaccharide export
BIZ35_RS06365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIZ35_RS06370	COG2226	methyltransferase
BIZ35_RS06375	COG0799	negative regulation of ribosome biogenesis
BIZ35_RS06380	COG1713	HD superfamily hydrolase involved in NAD metabolism
BIZ35_RS06385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BIZ35_RS06390	COG1534	Rna-binding protein
BIZ35_RS06400	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BIZ35_RS06405	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BIZ35_RS06410	COG0247	lactate metabolic process
BIZ35_RS06415	COG0277	FAD linked oxidase domain protein
BIZ35_RS06420	COG3835	regulator
BIZ35_RS06425	COG2132	Multicopper oxidase
BIZ35_RS06430	COG0071	Belongs to the small heat shock protein (HSP20) family
BIZ35_RS06435	COG2210	Belongs to the sulfur carrier protein TusA family
BIZ35_RS06450	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIZ35_RS06460	COG2132	Multicopper oxidase
BIZ35_RS06465	COG0071	Belongs to the small heat shock protein (HSP20) family
BIZ35_RS06475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ35_RS06485	COG1704	LemA family
BIZ35_RS06495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIZ35_RS06520	COG1183	phosphatidylcholine synthase activity
BIZ35_RS06540	COG0450	alkyl hydroperoxide reductase
BIZ35_RS06565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BIZ35_RS06570	COG0572	uridine kinase
BIZ35_RS06575	COG4122	O-methyltransferase activity
BIZ35_RS06580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BIZ35_RS06585	COG3906	Belongs to the UPF0473 family
BIZ35_RS06590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BIZ35_RS06595	COG4472	Bacterial protein of unknown function (DUF965)
BIZ35_RS06600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BIZ35_RS06605	COG0628	permease
BIZ35_RS06635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BIZ35_RS06645	COG0482	sulfurtransferase activity
BIZ35_RS06650	COG1104	cysteine desulfurase activity
BIZ35_RS06655	COG1959	2 iron, 2 sulfur cluster binding
BIZ35_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS06675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BIZ35_RS06680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BIZ35_RS06685	COG0385	Bile acid
BIZ35_RS06695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BIZ35_RS06700	COG0124	histidyl-tRNA synthetase
BIZ35_RS06705	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIZ35_RS06705	COG4991	sh3 domain protein
BIZ35_RS06705	COG3103	Sh3 type 3 domain protein
BIZ35_RS06710	COG2814	Major facilitator Superfamily
BIZ35_RS06715	COG1566	PFAM secretion protein HlyD family protein
BIZ35_RS06720	COG1846	Transcriptional regulator
BIZ35_RS06725	COG1490	D-aminoacyl-tRNA deacylase activity
BIZ35_RS06730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIZ35_RS06735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIZ35_RS06740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BIZ35_RS06740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BIZ35_RS06745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIZ35_RS06745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIZ35_RS06755	COG2244	polysaccharide biosynthetic process
BIZ35_RS06760	COG2323	membrane
BIZ35_RS06770	COG1862	Preprotein translocase
BIZ35_RS06775	COG0343	queuine tRNA-ribosyltransferase activity
BIZ35_RS06780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BIZ35_RS06795	COG0632	four-way junction helicase activity
BIZ35_RS06805	COG0217	transcriptional regulatory protein
BIZ35_RS06820	COG1827	regulation of RNA biosynthetic process
BIZ35_RS06825	COG0077	Prephenate dehydratase
BIZ35_RS06830	COG4492	Belongs to the UPF0735 family
BIZ35_RS06835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BIZ35_RS06840	COG3290	protein histidine kinase activity
BIZ35_RS06845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BIZ35_RS06850	COG2868	ribosomal protein
BIZ35_RS06855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BIZ35_RS06860	COG1530	ribonuclease E activity
BIZ35_RS06865	COG1994	Peptidase M50
BIZ35_RS06875	COG2894	cell division
BIZ35_RS06880	COG0850	regulation of cytokinetic process
BIZ35_RS06890	COG1792	Involved in formation and maintenance of cell shape
BIZ35_RS06895	COG1077	Cell shape determining protein MreB Mrl
BIZ35_RS06900	COG2003	Belongs to the UPF0758 family
BIZ35_RS06910	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BIZ35_RS06940	COG1459	type II secretion system
BIZ35_RS06950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BIZ35_RS06985	COG0285	dihydrofolate synthase activity
BIZ35_RS06990	COG0525	valine-tRNA ligase activity
BIZ35_RS07000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIZ35_RS07005	COG1388	LysM domain
BIZ35_RS07005	COG1388	LysM domain
BIZ35_RS07010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BIZ35_RS07015	COG0113	porphobilinogen synthase activity
BIZ35_RS07030	COG0181	hydroxymethylbilane synthase activity
BIZ35_RS07035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BIZ35_RS07050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BIZ35_RS07055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BIZ35_RS07060	COG1067	ATP-dependent peptidase activity
BIZ35_RS07060	COG0470	DNA polymerase III
BIZ35_RS07070	COG0544	peptidyl-prolyl cis-trans isomerase activity
BIZ35_RS07075	COG1477	protein flavinylation
BIZ35_RS07075	COG0457	Tetratricopeptide repeat
BIZ35_RS07105	COG0622	Phosphoesterase
BIZ35_RS07110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BIZ35_RS07115	COG5401	PFAM Sporulation and spore germination
BIZ35_RS07125	COG5577	PFAM Coat F domain
BIZ35_RS07130	COG1063	alcohol dehydrogenase
BIZ35_RS07135	COG5577	PFAM Coat F domain
BIZ35_RS07150	COG1846	Transcriptional regulator
BIZ35_RS07180	COG2197	response regulator
BIZ35_RS07185	COG0824	Thioesterase
BIZ35_RS07190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BIZ35_RS07195	COG1053	succinate dehydrogenase
BIZ35_RS07200	COG2009	succinate dehydrogenase
BIZ35_RS07205	COG1719	4-vinyl reductase, 4VR
BIZ35_RS07220	COG0322	excinuclease ABC activity
BIZ35_RS07225	COG3118	belongs to the thioredoxin family
BIZ35_RS07230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BIZ35_RS07235	COG2086	electron transfer activity
BIZ35_RS07240	COG1024	Enoyl-CoA hydratase
BIZ35_RS07245	COG1309	transcriptional regulator
BIZ35_RS07250	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_RS07255	COG1193	negative regulation of DNA recombination
BIZ35_RS07260	COG1796	DNA polymerase
BIZ35_RS07260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BIZ35_RS07265	COG1286	toxin biosynthetic process
BIZ35_RS07270	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BIZ35_RS07280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIZ35_RS07280	COG0072	phenylalanine-tRNA ligase activity
BIZ35_RS07285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BIZ35_RS07290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIZ35_RS07325	COG2329	Antibiotic biosynthesis monooxygenase
BIZ35_RS07335	COG1695	Transcriptional regulator
BIZ35_RS07355	COG0431	NADPH-dependent FMN reductase
BIZ35_RS07385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BIZ35_RS07395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BIZ35_RS07410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BIZ35_RS07420	COG1484	DNA-dependent DNA replication
BIZ35_RS07425	COG3611	Membrane attachment protein
BIZ35_RS07430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BIZ35_RS07435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BIZ35_RS07440	COG0237	dephospho-CoA kinase activity
BIZ35_RS07445	COG1971	Probably functions as a manganese efflux pump
BIZ35_RS07450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BIZ35_RS07455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIZ35_RS07455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIZ35_RS07465	COG0039	L-malate dehydrogenase activity
BIZ35_RS07470	COG0538	isocitrate dehydrogenase activity
BIZ35_RS07475	COG0372	Belongs to the citrate synthase family
BIZ35_RS07480	COG2707	UPF0756 membrane protein
BIZ35_RS07485	COG0628	permease
BIZ35_RS07495	COG0205	6-phosphofructokinase activity
BIZ35_RS07500	COG0825	malonyl-CoA metabolic process
BIZ35_RS07505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BIZ35_RS07510	COG0281	malic enzyme
BIZ35_RS07515	COG0587	DNA-directed DNA polymerase activity
BIZ35_RS07530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BIZ35_RS07540	COG4109	DRTGG domain
BIZ35_RS07545	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BIZ35_RS07550	COG0006	proline dipeptidase activity
BIZ35_RS07560	COG0589	response to stress
BIZ35_RS07570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIZ35_RS07575	COG0827	DNA restriction-modification system
BIZ35_RS07580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BIZ35_RS07585	COG3874	Sporulation protein YtfJ
BIZ35_RS07595	COG1714	RDD family
BIZ35_RS07600	COG0616	signal peptide processing
BIZ35_RS07605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIZ35_RS07615	COG0301	tRNA thio-modification
BIZ35_RS07620	COG1104	cysteine desulfurase activity
BIZ35_RS07625	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BIZ35_RS07630	COG1309	transcriptional regulator
BIZ35_RS07635	COG1956	GAF domain-containing protein
BIZ35_RS07640	COG2199	diguanylate cyclase activity
BIZ35_RS07640	COG2203	Gaf domain
BIZ35_RS07645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BIZ35_RS07660	COG0506	proline dehydrogenase activity
BIZ35_RS07665	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS07670	COG3829	transcription factor binding
BIZ35_RS07670	COG3290	protein histidine kinase activity
BIZ35_RS07685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BIZ35_RS07695	COG3383	formate dehydrogenase (NAD+) activity
BIZ35_RS07700	COG2427	Protein of unknown function (DUF1641)
BIZ35_RS07705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BIZ35_RS07710	COG0315	cyclic pyranopterin monophosphate synthase activity
BIZ35_RS07715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BIZ35_RS07720	COG0314	molybdopterin synthase activity
BIZ35_RS07725	COG1763	Mo-molybdopterin cofactor biosynthetic process
BIZ35_RS07730	COG0303	'Molybdopterin
BIZ35_RS07745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BIZ35_RS07750	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BIZ35_RS07755	COG4149	molybdate abc transporter
BIZ35_RS07765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIZ35_RS07770	COG0454	-acetyltransferase
BIZ35_RS07775	COG0517	IMP dehydrogenase activity
BIZ35_RS07780	COG0123	including yeast histone deacetylase and acetoin utilization protein
BIZ35_RS07790	COG1605	Chorismate mutase
BIZ35_RS07790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BIZ35_RS07795	COG4980	gas vesicle protein
BIZ35_RS07805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BIZ35_RS07810	COG1674	ftsk spoiiie
BIZ35_RS07820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIZ35_RS07825	COG4848	Belongs to the UPF0354 family
BIZ35_RS07830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ35_RS07835	COG2208	phosphoserine phosphatase activity
BIZ35_RS07840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BIZ35_RS07850	COG0784	Response regulator, receiver
BIZ35_RS07850	COG5002	protein histidine kinase activity
BIZ35_RS07875	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BIZ35_RS07880	COG1363	Peptidase, m42
BIZ35_RS07885	COG5584	Small secreted protein
BIZ35_RS07890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIZ35_RS07895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BIZ35_RS07905	COG0510	thiamine kinase activity
BIZ35_RS07925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIZ35_RS07930	COG1349	DNA-binding transcription factor activity
BIZ35_RS07935	COG2244	polysaccharide biosynthetic process
BIZ35_RS07955	COG0495	leucyl-tRNA aminoacylation
BIZ35_RS07960	COG2814	Major facilitator Superfamily
BIZ35_RS07970	COG0275	rRNA processing
BIZ35_RS07985	COG2267	carboxylic ester hydrolase activity
BIZ35_RS07990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BIZ35_RS07995	COG0367	asparagine synthase
BIZ35_RS08000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BIZ35_RS08005	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BIZ35_RS08015	COG1506	peptidase
BIZ35_RS08020	COG0655	NAD(P)H dehydrogenase (quinone) activity
BIZ35_RS08025	COG1070	Carbohydrate kinase
BIZ35_RS08030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIZ35_RS08035	COG1116	anion transmembrane transporter activity
BIZ35_RS08040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIZ35_RS08055	COG0783	Belongs to the Dps family
BIZ35_RS08060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BIZ35_RS08065	COG0803	Belongs to the bacterial solute-binding protein 9 family
BIZ35_RS08075	COG4948	Mandelate Racemase Muconate Lactonizing
BIZ35_RS08080	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_RS08085	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BIZ35_RS08090	COG0596	Alpha beta hydrolase
BIZ35_RS08095	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BIZ35_RS08100	COG1169	isochorismate synthase
BIZ35_RS08105	COG1575	Belongs to the MenA family. Type 1 subfamily
BIZ35_RS08250	COG1285	pathogenesis
BIZ35_RS08265	COG2217	Heavy metal translocating P-type atpase
BIZ35_RS08270	COG2608	mercury ion transmembrane transporter activity
BIZ35_RS08295	COG1522	sequence-specific DNA binding
BIZ35_RS08315	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIZ35_RS08340	COG5002	protein histidine kinase activity
BIZ35_RS08345	COG0745	RESPONSE REGULATOR receiver
BIZ35_RS08350	COG1388	LysM domain
BIZ35_RS08355	COG4221	oxidoreductase activity
BIZ35_RS08365	COG0726	polysaccharide deacetylase
BIZ35_RS08385	COG0038	chloride channel
BIZ35_RS08395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BIZ35_RS08395	COG0425	Belongs to the sulfur carrier protein TusA family
BIZ35_RS08400	COG1937	Protein conserved in bacteria
BIZ35_RS08410	COG1525	nuclease
BIZ35_RS08415	COG2190	(PTS) system
BIZ35_RS08435	COG3534	alpha-L-arabinofuranosidase
BIZ35_RS08440	COG2160	L-arabinose isomerase activity
BIZ35_RS08460	COG0395	ABC-type sugar transport system, permease component
BIZ35_RS08465	COG1175	transmembrane transport
BIZ35_RS08470	COG1653	transport
BIZ35_RS08475	COG1609	Transcriptional regulator
BIZ35_RS08480	COG3940	Belongs to the glycosyl hydrolase 43 family
BIZ35_RS08485	COG2223	nitrite transmembrane transporter activity
BIZ35_RS08490	COG3507	Belongs to the glycosyl hydrolase 43 family
BIZ35_RS08495	COG3328	transposase activity
BIZ35_RS08500	COG3507	Belongs to the glycosyl hydrolase 43 family
BIZ35_RS08505	COG0840	transmembrane signaling receptor activity
BIZ35_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS08525	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BIZ35_RS08540	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS08560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BIZ35_RS08570	COG2155	Conserved Protein
BIZ35_RS08580	COG1098	S1 RNA binding domain
BIZ35_RS08595	COG1902	pentaerythritol trinitrate reductase activity
BIZ35_RS08600	COG0656	L-ascorbic acid biosynthetic process
BIZ35_RS08620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BIZ35_RS08630	COG2814	Major facilitator Superfamily
BIZ35_RS08635	COG2050	protein possibly involved in aromatic compounds catabolism
BIZ35_RS08650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIZ35_RS08660	COG0697	spore germination
BIZ35_RS08670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BIZ35_RS08675	COG3584	3D domain protein
BIZ35_RS08690	COG1252	NADH dehydrogenase
BIZ35_RS08695	COG0492	ferredoxin-NADP+ reductase activity
BIZ35_RS08720	COG0316	Belongs to the HesB IscA family
BIZ35_RS08725	COG4837	Protein of unknown function (DUF1462)
BIZ35_RS08730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BIZ35_RS08740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIZ35_RS08745	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BIZ35_RS08750	COG0647	UMP catabolic process
BIZ35_RS08755	COG2445	Protein of unknown function DUF86
BIZ35_RS08760	COG4470	Protein conserved in bacteria
BIZ35_RS08765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BIZ35_RS08770	COG0739	heme binding
BIZ35_RS08780	COG3377	Domain of unknown function (DUF1805)
BIZ35_RS08785	COG0737	Belongs to the 5'-nucleotidase family
BIZ35_RS08790	COG0719	Fe-S assembly protein
BIZ35_RS08795	COG0822	iron-sulfur transferase activity
BIZ35_RS08800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BIZ35_RS08805	COG0719	Fe-S assembly protein
BIZ35_RS08810	COG0396	ATPase activity
BIZ35_RS08825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ35_RS08830	COG0509	glycine decarboxylation via glycine cleavage system
BIZ35_RS08835	COG1393	Belongs to the ArsC family
BIZ35_RS08840	COG1960	acyl-CoA dehydrogenase activity
BIZ35_RS08845	COG0183	Belongs to the thiolase family
BIZ35_RS08850	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIZ35_RS08850	COG1024	Enoyl-CoA hydratase
BIZ35_RS08860	COG5577	PFAM Coat F domain
BIZ35_RS08865	COG0772	Belongs to the SEDS family
BIZ35_RS08870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ35_RS08880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIZ35_RS08895	COG0753	catalase activity
BIZ35_RS08900	COG0671	phosphoesterase, PA-phosphatase related
BIZ35_RS08910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIZ35_RS08930	COG1595	DNA-templated transcription, initiation
BIZ35_RS08935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIZ35_RS08950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BIZ35_RS08960	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BIZ35_RS08965	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS08970	COG2211	Major facilitator Superfamily
BIZ35_RS08975	COG1904	glucuronate isomerase
BIZ35_RS08980	COG2721	sulfolactate sulfo-lyase activity
BIZ35_RS08985	COG0246	Mannitol dehydrogenase
BIZ35_RS08995	COG0800	Aldolase
BIZ35_RS09000	COG1414	Transcriptional regulator
BIZ35_RS09020	COG0488	(ABC) transporter
BIZ35_RS09090	COG0557	exoribonuclease II activity
BIZ35_RS09100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIZ35_RS09105	COG0148	phosphopyruvate hydratase activity
BIZ35_RS09110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BIZ35_RS09120	COG0126	phosphoglycerate kinase activity
BIZ35_RS09140	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BIZ35_RS09160	COG3383	formate dehydrogenase (NAD+) activity
BIZ35_RS09200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIZ35_RS09210	COG4608	Belongs to the ABC transporter superfamily
BIZ35_RS09215	COG0791	NLP P60 protein
BIZ35_RS09220	COG4166	transmembrane transport
BIZ35_RS09225	COG0444	Belongs to the ABC transporter superfamily
BIZ35_RS09230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIZ35_RS09235	COG0601	transmembrane transport
BIZ35_RS09240	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BIZ35_RS09250	COG0598	Magnesium transport protein CorA
BIZ35_RS09265	COG2719	SpoVR family
BIZ35_RS09270	COG3594	Acyltransferase
BIZ35_RS09295	COG1392	Phosphate transport regulator
BIZ35_RS09300	COG0306	phosphate transporter
BIZ35_RS09315	COG2718	Belongs to the UPF0229 family
BIZ35_RS09320	COG2766	serine protein kinase
BIZ35_RS09330	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BIZ35_RS09345	COG2095	MarC family integral membrane protein
BIZ35_RS09360	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BIZ35_RS09365	COG0596	Alpha beta hydrolase
BIZ35_RS09370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ35_RS09375	COG0765	amino acid transport
BIZ35_RS09380	COG1126	abc transporter atp-binding protein
BIZ35_RS09385	COG2116	formate transmembrane transporter activity
BIZ35_RS09410	COG1882	Formate acetyltransferase
BIZ35_RS09415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BIZ35_RS09420	COG0431	NADPH-dependent FMN reductase
BIZ35_RS09435	COG1131	(ABC) transporter
BIZ35_RS09460	COG0745	RESPONSE REGULATOR receiver
BIZ35_RS09465	COG3850	Histidine kinase
BIZ35_RS09465	COG5002	protein histidine kinase activity
BIZ35_RS09515	COG4977	sequence-specific DNA binding
BIZ35_RS09515	COG1917	Cupin 2, conserved barrel domain protein
BIZ35_RS09520	COG1874	Beta-galactosidase
BIZ35_RS09540	COG2271	Major facilitator Superfamily
BIZ35_RS09560	COG0697	spore germination
BIZ35_RS09575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIZ35_RS09695	COG3527	Alpha-acetolactate decarboxylase
BIZ35_RS09700	COG0028	Belongs to the TPP enzyme family
BIZ35_RS09705	COG0583	DNA-binding transcription factor activity
BIZ35_RS09710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ35_RS09715	COG0549	Belongs to the carbamate kinase family
BIZ35_RS09725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BIZ35_RS09735	COG0735	belongs to the Fur family
BIZ35_RS09750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BIZ35_RS09755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIZ35_RS09760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIZ35_RS09765	COG1116	anion transmembrane transporter activity
BIZ35_RS09770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIZ35_RS09775	COG2814	Major facilitator Superfamily
BIZ35_RS09790	COG4129	membrane
BIZ35_RS09795	COG1737	Transcriptional regulator
BIZ35_RS09800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_RS09800	COG1263	PTS System
BIZ35_RS09805	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BIZ35_RS09815	COG1132	(ABC) transporter
BIZ35_RS09820	COG3557	Belongs to the UPF0374 family
BIZ35_RS09835	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS09840	COG0583	DNA-binding transcription factor activity
BIZ35_RS09845	COG0069	glutamate synthase activity
BIZ35_RS09845	COG0070	glutamate synthase
BIZ35_RS09845	COG0067	glutamate synthase
BIZ35_RS09850	COG0493	'glutamate synthase
BIZ35_RS09870	COG1129	ABC transporter
BIZ35_RS09875	COG1194	a g-specific adenine glycosylase
BIZ35_RS09880	COG1988	membrane-bound metal-dependent
BIZ35_RS09905	COG0159	tryptophan synthase activity
BIZ35_RS09910	COG0133	tryptophan synthase activity
BIZ35_RS09915	COG0134	indole-3-glycerol-phosphate synthase activity
BIZ35_RS09920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIZ35_RS09925	COG0512	Glutamine amidotransferase of anthranilate synthase
BIZ35_RS09925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIZ35_RS09940	COG0577	efflux transmembrane transporter activity
BIZ35_RS09950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIZ35_RS09970	COG1131	(ABC) transporter
BIZ35_RS10010	COG2197	response regulator
BIZ35_RS10015	COG4585	Histidine kinase
BIZ35_RS10025	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS10025	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS10035	COG0058	SHG alpha-glucan phosphorylase activity
BIZ35_RS10040	COG0840	transmembrane signaling receptor activity
BIZ35_RS10045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIZ35_RS10050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BIZ35_RS10055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BIZ35_RS10070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BIZ35_RS10075	COG0066	3-isopropylmalate dehydratase activity
BIZ35_RS10080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BIZ35_RS10090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BIZ35_RS10095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BIZ35_RS10100	COG0440	acetolactate synthase activity
BIZ35_RS10105	COG0028	Belongs to the TPP enzyme family
BIZ35_RS10110	COG0129	dihydroxy-acid dehydratase activity
BIZ35_RS10120	COG1114	Component of the transport system for branched-chain amino acids
BIZ35_RS10125	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_RS10160	COG0670	Belongs to the BI1 family
BIZ35_RS10165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIZ35_RS10170	COG2223	nitrite transmembrane transporter activity
BIZ35_RS10175	COG3279	Response regulator of the LytR AlgR family
BIZ35_RS10180	COG3275	phosphorelay sensor kinase activity
BIZ35_RS10185	COG0252	asparaginase activity
BIZ35_RS10190	COG2132	Multicopper oxidase
BIZ35_RS10195	COG1309	transcriptional regulator
BIZ35_RS10200	COG1511	domain protein
BIZ35_RS10235	COG0840	transmembrane signaling receptor activity
BIZ35_RS10235	COG5278	phosphoserine phosphatase activity
BIZ35_RS10240	COG3739	integral membrane protein
BIZ35_RS10245	COG3655	Transcriptional regulator
BIZ35_RS10260	COG1823	symporter activity
BIZ35_RS10265	COG2839	Protein conserved in bacteria
BIZ35_RS10285	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
BIZ35_RS10310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIZ35_RS10315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BIZ35_RS10320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BIZ35_RS10325	COG0840	transmembrane signaling receptor activity
BIZ35_RS10345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BIZ35_RS10350	COG1132	(ABC) transporter
BIZ35_RS10355	COG1846	Transcriptional regulator
BIZ35_RS10380	COG0798	PFAM Bile acid sodium symporter
BIZ35_RS10420	COG0024	Methionine aminopeptidase
BIZ35_RS10440	COG0464	growth
BIZ35_RS10505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIZ35_RS10510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BIZ35_RS10535	COG0387	Pfam Sodium calcium exchanger
BIZ35_RS10540	COG0477	Major facilitator Superfamily
BIZ35_RS10545	COG1295	ribonuclease BN
BIZ35_RS10550	COG4840	Belongs to the UPF0435 family
BIZ35_RS10555	COG0024	Methionine aminopeptidase
BIZ35_RS10560	COG0693	protein deglycase activity
BIZ35_RS10565	COG1360	Flagellar Motor Protein
BIZ35_RS10570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BIZ35_RS10580	COG3189	MarR family transcriptional regulator
BIZ35_RS10590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BIZ35_RS10595	COG1607	acyl-coa hydrolase
BIZ35_RS10600	COG1077	Cell shape determining protein MreB Mrl
BIZ35_RS10605	COG2268	Band 7 protein
BIZ35_RS10610	COG1585	Membrane protein implicated in regulation of membrane protease activity
BIZ35_RS10615	COG0626	cystathionine gamma-synthase activity
BIZ35_RS10620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BIZ35_RS10625	COG1854	S-ribosylhomocysteine lyase activity
BIZ35_RS10635	COG0288	reversible hydration of carbon dioxide
BIZ35_RS10645	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIZ35_RS10660	COG2197	response regulator
BIZ35_RS10680	COG4086	secreted protein
BIZ35_RS10685	COG0737	Belongs to the 5'-nucleotidase family
BIZ35_RS10700	COG3620	sequence-specific DNA binding
BIZ35_RS10705	COG3328	transposase activity
BIZ35_RS10725	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BIZ35_RS10730	COG1518	maintenance of DNA repeat elements
BIZ35_RS10790	COG1304	FMN binding
BIZ35_RS10795	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BIZ35_RS10800	COG0166	Belongs to the GPI family
BIZ35_RS10805	COG0025	NhaP-type Na H and K H
BIZ35_RS10815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIZ35_RS10815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_RS10815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIZ35_RS10820	COG1349	DNA-binding transcription factor activity
BIZ35_RS10830	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BIZ35_RS10840	COG0561	phosphatase activity
BIZ35_RS10855	COG2814	Major facilitator Superfamily
BIZ35_RS10860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BIZ35_RS10885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BIZ35_RS10890	COG0667	Aldo Keto reductase
BIZ35_RS10895	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BIZ35_RS10900	COG1461	Dihydroxyacetone kinase
BIZ35_RS10905	COG2376	Dihydroxyacetone kinase
BIZ35_RS10915	COG0778	Nitroreductase
BIZ35_RS10920	COG1113	amino acid transport
BIZ35_RS10925	COG0730	response to heat
BIZ35_RS10935	COG2233	PERMEase
BIZ35_RS10945	COG2233	PERMEase
BIZ35_RS10955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIZ35_RS10975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BIZ35_RS10980	COG1024	Enoyl-CoA hydratase
BIZ35_RS10990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BIZ35_RS10995	COG0511	ligase activity, forming carbon-carbon bonds
BIZ35_RS11000	COG0439	Biotin carboxylase
BIZ35_RS11005	COG1960	acyl-CoA dehydrogenase activity
BIZ35_RS11010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIZ35_RS11030	COG1349	DNA-binding transcription factor activity
BIZ35_RS11040	COG2376	Dihydroxyacetone kinase
BIZ35_RS11050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BIZ35_RS11060	COG2271	Major facilitator Superfamily
BIZ35_RS11065	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIZ35_RS11080	COG0698	ribose 5-phosphate isomerase
BIZ35_RS11085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BIZ35_RS11090	COG1494	fructose-1,6-bisphosphatase
BIZ35_RS11095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BIZ35_RS11100	COG3829	transcription factor binding
BIZ35_RS11105	COG0833	amino acid
BIZ35_RS11145	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BIZ35_RS11150	COG1140	nitrate reductase beta subunit
BIZ35_RS11160	COG2181	nitrate reductase activity
BIZ35_RS11165	COG2223	nitrite transmembrane transporter activity
BIZ35_RS11170	COG3588	fructose-bisphosphate aldolase
BIZ35_RS11175	COG1657	PFAM Prenyltransferase squalene oxidase
BIZ35_RS11180	COG1349	DNA-binding transcription factor activity
BIZ35_RS11220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BIZ35_RS11245	COG1280	lysine exporter protein (LysE YggA)
BIZ35_RS11250	COG0386	Belongs to the glutathione peroxidase family
BIZ35_RS11255	COG2190	(PTS) system
BIZ35_RS11275	COG0582	viral genome integration into host DNA
BIZ35_RS11300	COG1328	CTP reductase activity
BIZ35_RS11310	COG1063	alcohol dehydrogenase
BIZ35_RS11315	COG1929	Belongs to the glycerate kinase type-1 family
BIZ35_RS11330	COG1879	ABC-type sugar transport system periplasmic component
BIZ35_RS11335	COG1172	Belongs to the binding-protein-dependent transport system permease family
BIZ35_RS11340	COG1129	ABC transporter
BIZ35_RS11345	COG1869	D-ribose catabolic process
BIZ35_RS11350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIZ35_RS11355	COG1609	Transcriptional regulator
BIZ35_RS11390	COG4549	nuclear export factor GLE1
BIZ35_RS11395	COG2372	response to copper ion
BIZ35_RS11395	COG1276	copper resistance
BIZ35_RS11405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BIZ35_RS11410	COG1609	Transcriptional regulator
BIZ35_RS11425	COG5002	protein histidine kinase activity
BIZ35_RS11430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIZ35_RS11445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BIZ35_RS11455	COG2204	response regulator
BIZ35_RS11460	COG1606	tRNA processing
BIZ35_RS11465	COG2610	gluconate transmembrane transporter activity
BIZ35_RS11470	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BIZ35_RS11475	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BIZ35_RS11480	COG1691	(AIR) carboxylase
BIZ35_RS11500	COG1278	Cold shock
BIZ35_RS11515	COG0697	spore germination
BIZ35_RS11520	COG1472	Belongs to the glycosyl hydrolase 3 family
BIZ35_RS11530	COG3876	Protein conserved in bacteria
BIZ35_RS11545	COG1132	(ABC) transporter
BIZ35_RS11550	COG1132	(ABC) transporter
BIZ35_RS11560	COG1349	DNA-binding transcription factor activity
BIZ35_RS11565	COG1082	Xylose isomerase domain protein TIM barrel
BIZ35_RS11570	COG1082	Xylose isomerase domain protein TIM barrel
BIZ35_RS11575	COG0673	inositol 2-dehydrogenase activity
BIZ35_RS11580	COG2814	Major facilitator Superfamily
BIZ35_RS11585	COG1082	Xylose isomerase domain protein TIM barrel
BIZ35_RS11590	COG0673	inositol 2-dehydrogenase activity
BIZ35_RS11595	COG1082	Xylose isomerase domain protein TIM barrel
BIZ35_RS11600	COG0673	inositol 2-dehydrogenase activity
BIZ35_RS11605	COG1082	Xylose isomerase domain protein TIM barrel
BIZ35_RS11610	COG2814	Major facilitator Superfamily
BIZ35_RS11615	COG2814	Major facilitator Superfamily
BIZ35_RS11620	COG0191	fructose-bisphosphate aldolase activity
BIZ35_RS11625	COG3962	Belongs to the TPP enzyme family
BIZ35_RS11630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIZ35_RS11635	COG3718	enzyme involved in inositol metabolism
BIZ35_RS11640	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS11645	COG1388	LysM domain
BIZ35_RS11645	COG0791	NLP P60 protein
BIZ35_RS11665	COG2272	Belongs to the type-B carboxylesterase lipase family
BIZ35_RS11670	COG0154	amidase activity
BIZ35_RS11675	COG2814	Major facilitator Superfamily
BIZ35_RS11680	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS11705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BIZ35_RS11705	COG3153	acetyltransferase
BIZ35_RS11710	COG5583	Uncharacterized small protein (DUF2292)
BIZ35_RS11715	COG0431	NADPH-dependent FMN reductase
BIZ35_RS11720	COG1116	anion transmembrane transporter activity
BIZ35_RS11725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIZ35_RS11730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIZ35_RS11735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIZ35_RS11760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIZ35_RS11775	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BIZ35_RS11785	COG2390	Transcriptional regulator
BIZ35_RS11795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BIZ35_RS11805	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BIZ35_RS11820	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BIZ35_RS11825	COG1984	allophanate hydrolase subunit 2
BIZ35_RS11830	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BIZ35_RS11835	COG2814	Major facilitator Superfamily
BIZ35_RS11840	COG1764	response to oxidative stress
BIZ35_RS11845	COG1126	abc transporter atp-binding protein
BIZ35_RS11850	COG0765	amino acid transport
BIZ35_RS11855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ35_RS11865	COG0326	Molecular chaperone. Has ATPase activity
BIZ35_RS11885	COG0800	Aldolase
BIZ35_RS11900	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_RS11905	COG3716	PTS system mannose fructose sorbose family IID component
BIZ35_RS11915	COG0371	Dehydrogenase
BIZ35_RS11925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIZ35_RS11930	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BIZ35_RS11940	COG1737	Transcriptional regulator
BIZ35_RS11945	COG0561	phosphatase activity
BIZ35_RS11960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIZ35_RS11975	COG1064	alcohol dehydrogenase
BIZ35_RS12010	COG2814	Major facilitator Superfamily
BIZ35_RS12015	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS12060	COG3716	PTS system mannose fructose sorbose family IID component
BIZ35_RS12155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIZ35_RS12165	COG1597	lipid kinase activity
BIZ35_RS12190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIZ35_RS12195	COG0154	amidase activity
BIZ35_RS12200	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIZ35_RS12205	COG2224	Isocitrate lyase
BIZ35_RS12210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BIZ35_RS12215	COG4851	CamS sex pheromone cAM373 precursor
BIZ35_RS12225	COG0210	DNA helicase
BIZ35_RS12230	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BIZ35_RS12235	COG4496	protein, YerC YecD
BIZ35_RS12240	COG1470	cell adhesion involved in biofilm formation
BIZ35_RS12255	COG0151	Belongs to the GarS family
BIZ35_RS12260	COG0138	bifunctional purine biosynthesis protein purh
BIZ35_RS12265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BIZ35_RS12270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BIZ35_RS12275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BIZ35_RS12280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIZ35_RS12285	COG0047	phosphoribosylformylglycinamidine synthase activity
BIZ35_RS12290	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIZ35_RS12300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BIZ35_RS12305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BIZ35_RS12310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BIZ35_RS12320	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BIZ35_RS12325	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BIZ35_RS12345	COG1301	dicarboxylic acid transport
BIZ35_RS12355	COG3711	transcriptional antiterminator
BIZ35_RS12360	COG2252	PERMEase
BIZ35_RS12370	COG1132	(ABC) transporter
BIZ35_RS12375	COG2814	Major facilitator Superfamily
BIZ35_RS12380	COG2197	response regulator
BIZ35_RS12385	COG3850	Histidine kinase
BIZ35_RS12390	COG1131	(ABC) transporter
BIZ35_RS12400	COG0842	Transport permease protein
BIZ35_RS12420	COG0471	metal ion transport
BIZ35_RS12445	COG1131	(ABC) transporter
BIZ35_RS12450	COG1725	Transcriptional regulator
BIZ35_RS12455	COG1695	Transcriptional regulator
BIZ35_RS12460	COG3479	Phenolic acid decarboxylase
BIZ35_RS12465	COG2910	NAD(P)H-binding
BIZ35_RS12470	COG1959	2 iron, 2 sulfur cluster binding
BIZ35_RS12490	COG0425	Belongs to the sulfur carrier protein TusA family
BIZ35_RS12495	COG2391	methyltransferase activity
BIZ35_RS12505	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS12525	COG1120	ATPase activity
BIZ35_RS12530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIZ35_RS12550	COG3620	sequence-specific DNA binding
BIZ35_RS12565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BIZ35_RS12565	COG0519	Catalyzes the synthesis of GMP from XMP
BIZ35_RS12570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BIZ35_RS12575	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BIZ35_RS12580	COG1335	isochorismatase
BIZ35_RS12590	COG4948	Mandelate Racemase Muconate Lactonizing
BIZ35_RS12600	COG0463	Glycosyl transferase, family 2
BIZ35_RS12605	COG2246	polysaccharide biosynthetic process
BIZ35_RS12610	COG0459	protein refolding
BIZ35_RS12615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BIZ35_RS12620	COG1266	CAAX protease self-immunity
BIZ35_RS12630	COG0805	protein transport
BIZ35_RS12635	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BIZ35_RS12640	COG0488	(ABC) transporter
BIZ35_RS12655	COG0456	acetyltransferase
BIZ35_RS12660	COG1214	PFAM Peptidase M22, glycoprotease
BIZ35_RS12665	COG0802	atpase or kinase
BIZ35_RS12750	COG3091	SprT-like family
BIZ35_RS12760	COG2183	response to ionizing radiation
BIZ35_RS12765	COG2208	phosphoserine phosphatase activity
BIZ35_RS12770	COG1191	sigma factor activity
BIZ35_RS12775	COG2172	sigma factor antagonist activity
BIZ35_RS12780	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_RS12785	COG2208	phosphoserine phosphatase activity
BIZ35_RS12790	COG2172	sigma factor antagonist activity
BIZ35_RS12795	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_RS12800	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_RS12810	COG2337	Toxic component of a toxin-antitoxin (TA) module
BIZ35_RS12815	COG0864	Transcriptional regulator
BIZ35_RS12825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BIZ35_RS12830	COG0736	holo-[acyl-carrier-protein] synthase activity
BIZ35_RS12835	COG0705	Rhomboid family
BIZ35_RS12845	COG0513	Belongs to the DEAD box helicase family
BIZ35_RS12860	COG1280	lysine exporter protein (LysE YggA)
BIZ35_RS12870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIZ35_RS12875	COG1609	Transcriptional regulator
BIZ35_RS12880	COG0366	Alpha amylase catalytic
BIZ35_RS12890	COG2182	Extracellular solute-binding protein
BIZ35_RS12895	COG1175	transmembrane transport
BIZ35_RS12900	COG3833	ABC-type maltose transport systems, permease component
BIZ35_RS12905	COG5521	maltodextrose utilization protein MalA
BIZ35_RS12910	COG1554	hydrolase, family 65, central catalytic
BIZ35_RS12920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIZ35_RS12925	COG1181	Belongs to the D-alanine--D-alanine ligase family
BIZ35_RS12940	COG1253	flavin adenine dinucleotide binding
BIZ35_RS12945	COG0789	Transcriptional regulator
BIZ35_RS12950	COG1253	flavin adenine dinucleotide binding
BIZ35_RS12960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BIZ35_RS12975	COG0629	single-stranded DNA binding
BIZ35_RS12980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BIZ35_RS12985	COG4786	Flagellar basal body rod
BIZ35_RS12990	COG4786	Flagellar basal body rod
BIZ35_RS12995	COG1077	Cell shape determining protein MreB Mrl
BIZ35_RS13000	COG1609	Transcriptional regulator
BIZ35_RS13005	COG0739	heme binding
BIZ35_RS13010	COG2385	sporulation resulting in formation of a cellular spore
BIZ35_RS13020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIZ35_RS13030	COG4836	Membrane
BIZ35_RS13035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BIZ35_RS13040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BIZ35_RS13045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BIZ35_RS13050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BIZ35_RS13055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIZ35_RS13065	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIZ35_RS13070	COG0356	it plays a direct role in the translocation of protons across the membrane
BIZ35_RS13080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BIZ35_RS13085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BIZ35_RS13095	COG4475	Protein of unknown function (DUF436)
BIZ35_RS13100	COG0698	ribose 5-phosphate isomerase
BIZ35_RS13105	COG0840	transmembrane signaling receptor activity
BIZ35_RS13115	COG1971	Probably functions as a manganese efflux pump
BIZ35_RS13120	COG0009	L-threonylcarbamoyladenylate synthase
BIZ35_RS13135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BIZ35_RS13145	COG1435	thymidine kinase activity
BIZ35_RS13150	COG0254	rRNA binding
BIZ35_RS13155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BIZ35_RS13160	COG1494	fructose-1,6-bisphosphatase
BIZ35_RS13165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIZ35_RS13170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BIZ35_RS13175	COG0191	fructose-bisphosphate aldolase activity
BIZ35_RS13180	COG2204	response regulator
BIZ35_RS13195	COG1131	(ABC) transporter
BIZ35_RS13200	COG1725	Transcriptional regulator
BIZ35_RS13205	COG0504	CTP synthase activity
BIZ35_RS13210	COG3343	RNA polymerase activity
BIZ35_RS13220	COG1136	(ABC) transporter
BIZ35_RS13235	COG1309	transcriptional regulator
BIZ35_RS13240	COG1960	acyl-CoA dehydrogenase activity
BIZ35_RS13245	COG1960	acyl-CoA dehydrogenase activity
BIZ35_RS13250	COG0183	Belongs to the thiolase family
BIZ35_RS13255	COG2181	nitrate reductase activity
BIZ35_RS13255	COG0247	lactate metabolic process
BIZ35_RS13260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIZ35_RS13265	COG0018	arginyl-trna synthetase
BIZ35_RS13275	COG0010	Belongs to the arginase family
BIZ35_RS13280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIZ35_RS13290	COG1994	Peptidase M50
BIZ35_RS13300	COG3465	dGTPase activity
BIZ35_RS13305	COG1078	dGTPase activity
BIZ35_RS13320	COG0095	Lipoate-protein ligase
BIZ35_RS13325	COG0280	phosphate acetyltransferase
BIZ35_RS13330	COG3253	May function as heme-dependent peroxidase
BIZ35_RS13340	COG2363	Small membrane protein
BIZ35_RS13355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BIZ35_RS13390	COG4555	ABC transporter
BIZ35_RS13405	COG1122	ATPase activity
BIZ35_RS13420	COG0351	phosphomethylpyrimidine kinase
BIZ35_RS13435	COG0561	phosphatase activity
BIZ35_RS13440	COG0514	ATP-dependent DNA helicase (RecQ)
BIZ35_RS13445	COG1785	Belongs to the alkaline phosphatase family
BIZ35_RS13450	COG1737	Transcriptional regulator
BIZ35_RS13460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIZ35_RS13465	COG1346	cytolysis
BIZ35_RS13470	COG1380	Effector of murein hydrolase LrgA
BIZ35_RS13475	COG0583	DNA-binding transcription factor activity
BIZ35_RS13480	COG0367	asparagine synthase
BIZ35_RS13505	COG2966	Psort location CytoplasmicMembrane, score
BIZ35_RS13510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIZ35_RS13515	COG1966	Carbon starvation protein
BIZ35_RS13525	COG3275	phosphorelay sensor kinase activity
BIZ35_RS13535	COG1464	Belongs to the NlpA lipoprotein family
BIZ35_RS13540	COG2011	ABC-type metal ion transport system permease component
BIZ35_RS13545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIZ35_RS13550	COG1119	ATPase activity
BIZ35_RS13565	COG0534	Mate efflux family protein
BIZ35_RS13570	COG1442	glycosyl transferase family 8
BIZ35_RS13575	COG2195	Cleaves the N-terminal amino acid of tripeptides
BIZ35_RS13580	COG2814	Major facilitator Superfamily
BIZ35_RS13595	COG0028	Belongs to the TPP enzyme family
BIZ35_RS13615	COG3842	ATPase activity
BIZ35_RS13635	COG0584	glycerophosphoryl diester phosphodiesterase
BIZ35_RS13675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BIZ35_RS13695	COG2188	Transcriptional regulator
BIZ35_RS13700	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BIZ35_RS13705	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_RS13730	COG3457	Alanine racemase
BIZ35_RS13740	COG1126	abc transporter atp-binding protein
BIZ35_RS13750	COG0765	amino acid transport
BIZ35_RS13755	COG0579	oxidoreductase
BIZ35_RS13760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BIZ35_RS13765	COG0732	type I restriction modification DNA specificity domain
BIZ35_RS13770	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BIZ35_RS13780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BIZ35_RS13785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIZ35_RS13790	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BIZ35_RS13795	COG4853	Protein conserved in bacteria
BIZ35_RS13800	COG4863	YycH protein
BIZ35_RS13805	COG5002	protein histidine kinase activity
BIZ35_RS13810	COG0745	RESPONSE REGULATOR receiver
BIZ35_RS13825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BIZ35_RS13830	COG0305	Participates in initiation and elongation during chromosome replication
BIZ35_RS13835	COG0359	binds to the 23S rRNA
BIZ35_RS13840	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BIZ35_RS13850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BIZ35_RS13855	COG0629	single-stranded DNA binding
BIZ35_RS13860	COG0360	Binds together with S18 to 16S ribosomal RNA
BIZ35_RS13865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BIZ35_RS13870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIZ35_RS13870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIZ35_RS13875	COG0307	riboflavin synthase, alpha
BIZ35_RS13880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIZ35_RS13880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIZ35_RS13885	COG0012	GTP binding
BIZ35_RS13890	COG4481	Protein conserved in bacteria
BIZ35_RS13895	COG0668	transmembrane transport
BIZ35_RS13910	COG1475	DNA binding
BIZ35_RS13915	COG1192	Involved in chromosome partitioning
BIZ35_RS13920	COG1475	DNA binding
BIZ35_RS13925	COG0357	Ribosomal RNA small subunit methyltransferase G
BIZ35_RS13930	COG0445	tRNA wobble uridine modification
BIZ35_RS13935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BIZ35_RS13940	COG1847	R3H domain protein
BIZ35_RS13945	COG0706	membrane insertase activity
BIZ35_RS13950	COG0594	ribonuclease P activity
BIZ35_RS13955	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BIZ35_RS13965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BIZ35_RS13970	COG0592	DNA-directed DNA polymerase activity
BIZ35_RS13975	COG2501	S4 domain
BIZ35_RS13980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BIZ35_RS13990	COG0187	DNA topoisomerase II activity
BIZ35_RS13995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIZ35_RS14000	COG3437	response regulator, receiver
BIZ35_RS14035	COG1982	Orn Lys Arg decarboxylase major
BIZ35_RS14045	COG3870	Protein conserved in bacteria
BIZ35_RS14050	COG1728	Protein conserved in bacteria
BIZ35_RS14055	COG0470	DNA polymerase III
BIZ35_RS14060	COG1774	PSP1 C-terminal conserved region
BIZ35_RS14065	COG4467	Involved in initiation control of chromosome replication
BIZ35_RS14070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BIZ35_RS14075	COG2827	Endonuclease containing a URI domain
BIZ35_RS14080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BIZ35_RS14085	COG2002	toxin-antitoxin pair type II binding
BIZ35_RS14095	COG0084	hydrolase, TatD family'
BIZ35_RS14105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BIZ35_RS14120	COG4466	Protein conserved in bacteria
BIZ35_RS14130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BIZ35_RS14135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIZ35_RS14140	COG0251	oxidation-reduction process
BIZ35_RS14180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BIZ35_RS14185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BIZ35_RS14190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BIZ35_RS14195	COG0193	aminoacyl-tRNA hydrolase activity
BIZ35_RS14205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BIZ35_RS14210	COG2002	toxin-antitoxin pair type II binding
BIZ35_RS14215	COG2244	polysaccharide biosynthetic process
BIZ35_RS14220	COG3956	TIGRFAM MazG family protein
BIZ35_RS14225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BIZ35_RS14245	COG1098	S1 RNA binding domain
BIZ35_RS14255	COG2208	phosphoserine phosphatase activity
BIZ35_RS14260	COG2304	oxidoreductase activity
BIZ35_RS14265	COG0515	serine threonine protein kinase
BIZ35_RS14270	COG0037	tRNA processing
BIZ35_RS14275	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BIZ35_RS14280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIZ35_RS14285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BIZ35_RS14290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BIZ35_RS14295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BIZ35_RS14300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BIZ35_RS14305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BIZ35_RS14310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BIZ35_RS14390	COG0516	GMP reductase activity
BIZ35_RS14390	COG0517	IMP dehydrogenase activity
BIZ35_RS14405	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BIZ35_RS14415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIZ35_RS14430	COG1428	Deoxynucleoside kinase
BIZ35_RS14435	COG1428	Deoxynucleoside kinase
BIZ35_RS14450	COG0590	tRNA wobble adenosine to inosine editing
BIZ35_RS14460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BIZ35_RS14465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BIZ35_RS14470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BIZ35_RS14525	COG3880	PFAM UvrB UvrC protein
BIZ35_RS14530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BIZ35_RS14535	COG0542	response to heat
BIZ35_RS14540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BIZ35_RS14545	COG4956	integral membrane protein (PIN domain superfamily)
BIZ35_RS14555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BIZ35_RS14560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BIZ35_RS14565	COG1045	serine acetyltransferase
BIZ35_RS14570	COG0215	cysteine-tRNA ligase activity
BIZ35_RS14580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIZ35_RS14585	COG3688	RNA-binding protein containing a PIN domain
BIZ35_RS14595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BIZ35_RS14600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIZ35_RS14605	COG0250	Participates in transcription elongation, termination and antitermination
BIZ35_RS14610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BIZ35_RS14615	COG0081	regulation of translation
BIZ35_RS14620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BIZ35_RS14630	COG2813	Specifically methylates the guanine in position
BIZ35_RS14635	COG0085	RNA polymerase activity
BIZ35_RS14645	COG1358	cellular component organization or biogenesis
BIZ35_RS14650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BIZ35_RS14655	COG0049	tRNA binding
BIZ35_RS14660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BIZ35_RS14665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BIZ35_RS14680	COG0051	transcription antitermination factor activity, RNA binding
BIZ35_RS14700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BIZ35_RS14705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BIZ35_RS14715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BIZ35_RS14720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BIZ35_RS14725	COG0255	Belongs to the universal ribosomal protein uL29 family
BIZ35_RS14730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BIZ35_RS14735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BIZ35_RS14740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BIZ35_RS14750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIZ35_RS14755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BIZ35_RS14760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BIZ35_RS14765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BIZ35_RS14770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BIZ35_RS14780	COG0200	Binds to the 23S rRNA
BIZ35_RS14785	COG0201	protein transport
BIZ35_RS14790	COG0563	adenylate kinase activity
BIZ35_RS14795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BIZ35_RS14800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BIZ35_RS14805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BIZ35_RS14810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BIZ35_RS14815	COG0202	RNA polymerase activity
BIZ35_RS14820	COG0203	ribosomal protein L17
BIZ35_RS14825	COG1122	ATPase activity
BIZ35_RS14830	COG1122	ATPase activity
BIZ35_RS14835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIZ35_RS14845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BIZ35_RS14850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BIZ35_RS14855	COG0753	catalase activity
BIZ35_RS14870	COG2046	Belongs to the sulfate adenylyltransferase family
BIZ35_RS14875	COG0529	Catalyzes the synthesis of activated sulfate
BIZ35_RS14880	COG0833	amino acid
BIZ35_RS14890	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIZ35_RS14895	COG0489	protein tyrosine kinase activity
BIZ35_RS14910	COG2194	sulfuric ester hydrolase activity
BIZ35_RS14940	COG0662	Cupin 2, conserved barrel domain protein
BIZ35_RS14950	COG0726	polysaccharide deacetylase
BIZ35_RS14960	COG1271	oxidase subunit
BIZ35_RS14965	COG1294	oxidase, subunit
BIZ35_RS14970	COG4988	ABC transporter
BIZ35_RS14975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BIZ35_RS15050	COG1525	nuclease
BIZ35_RS15065	COG3620	sequence-specific DNA binding
BIZ35_RS15110	COG5377	YqaJ viral recombinase family
BIZ35_RS15115	COG3723	Recombinational DNA repair protein, rece pathway
BIZ35_RS15180	COG4566	intracellular signal transduction
BIZ35_RS15310	COG1388	LysM domain
BIZ35_RS15310	COG3942	CHAP domain
BIZ35_RS15335	COG1595	DNA-templated transcription, initiation
BIZ35_RS15340	COG5662	AntiSigma factor
BIZ35_RS15345	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BIZ35_RS15350	COG4856	YbbR-like protein
BIZ35_RS15355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIZ35_RS15360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BIZ35_RS15385	COG2814	Major facilitator Superfamily
BIZ35_RS15390	COG0583	DNA-binding transcription factor activity
BIZ35_RS15405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BIZ35_RS15410	COG0840	transmembrane signaling receptor activity
BIZ35_RS15425	COG1695	Transcriptional regulator
BIZ35_RS15435	COG0840	transmembrane signaling receptor activity
BIZ35_RS15440	COG0477	Major facilitator Superfamily
BIZ35_RS15495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIZ35_RS15500	COG2814	Major facilitator Superfamily
BIZ35_RS15515	COG0519	Catalyzes the synthesis of GMP from XMP
BIZ35_RS15540	COG2814	Major facilitator Superfamily
BIZ35_RS15540	COG0477	Major facilitator Superfamily
BIZ35_RS15575	COG3425	synthase
BIZ35_RS15580	COG0183	Belongs to the thiolase family
BIZ35_RS15605	COG1125	glycine betaine transport
BIZ35_RS15605	COG0517	IMP dehydrogenase activity
BIZ35_RS15610	COG1174	glycine betaine transport
BIZ35_RS15615	COG2190	(PTS) system
BIZ35_RS15620	COG1263	PTS System
BIZ35_RS15620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_RS15625	COG0366	Alpha amylase catalytic
BIZ35_RS15630	COG2188	Transcriptional regulator
BIZ35_RS15640	COG1070	Carbohydrate kinase
BIZ35_RS15650	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BIZ35_RS15655	COG0716	FMN binding
BIZ35_RS15660	COG0322	excinuclease ABC activity
BIZ35_RS15665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ35_RS15675	COG2608	mercury ion transmembrane transporter activity
BIZ35_RS15680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ35_RS15690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ35_RS15695	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BIZ35_RS15700	COG0463	Glycosyl transferase, family 2
BIZ35_RS15730	COG2076	Multidrug Resistance protein
BIZ35_RS15735	COG2076	Multidrug Resistance protein
BIZ35_RS15745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIZ35_RS15750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIZ35_RS15755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIZ35_RS15765	COG1120	ATPase activity
BIZ35_RS15795	COG0217	transcriptional regulatory protein
BIZ35_RS15800	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_RS15810	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS15820	COG1309	transcriptional regulator
BIZ35_RS15835	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS15845	COG0765	amino acid transport
BIZ35_RS15855	COG5434	Belongs to the glycosyl hydrolase 28 family
BIZ35_RS15860	COG0175	sulfate reduction
BIZ35_RS15880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIZ35_RS15885	COG0371	Dehydrogenase
BIZ35_RS15890	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_RS15905	COG0697	spore germination
BIZ35_RS15925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BIZ35_RS15940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BIZ35_RS15965	COG0702	epimerase
BIZ35_RS15985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_RS15985	COG2213	PTS system mannitol-specific
BIZ35_RS15990	COG3711	transcriptional antiterminator
BIZ35_RS15995	COG0246	Mannitol dehydrogenase
BIZ35_RS16000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BIZ35_RS16020	COG2848	UPF0210 protein
BIZ35_RS16025	COG1609	Transcriptional regulator
BIZ35_RS16040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIZ35_RS16055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BIZ35_RS16065	COG5577	PFAM Coat F domain
BIZ35_RS16075	COG0667	Aldo Keto reductase
BIZ35_RS16085	COG1113	amino acid transport
BIZ35_RS16090	COG3104	oligopeptide transport
BIZ35_RS16095	COG0833	amino acid
BIZ35_RS16115	COG3842	ATPase activity
BIZ35_RS16120	COG1176	ABC-type spermidine putrescine transport system, permease component I
BIZ35_RS16145	COG0531	amino acid
BIZ35_RS16150	COG1556	Lactate utilization protein
BIZ35_RS16155	COG1139	Iron-sulfur cluster binding protein
BIZ35_RS16160	COG0247	lactate metabolic process
BIZ35_RS16170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BIZ35_RS16175	COG1454	alcohol dehydrogenase
BIZ35_RS16185	COG1953	Uracil, thiamine, allantoin
BIZ35_RS16210	COG0531	amino acid
BIZ35_RS16215	COG1979	alcohol dehydrogenase
BIZ35_RS16220	COG0004	ammonium transporteR
BIZ35_RS16225	COG3290	protein histidine kinase activity
BIZ35_RS16230	COG4565	transcriptional regulatory protein
BIZ35_RS16235	COG2851	Citrate transporter
BIZ35_RS16240	COG0463	Glycosyl transferase, family 2
BIZ35_RS16245	COG3973	AAA domain
BIZ35_RS16275	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BIZ35_RS16280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIZ35_RS16285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIZ35_RS16295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BIZ35_RS16300	COG1301	dicarboxylic acid transport
BIZ35_RS16305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ35_RS16335	COG1902	pentaerythritol trinitrate reductase activity
BIZ35_RS16355	COG0423	glycine-tRNA ligase activity
BIZ35_RS16360	COG0531	amino acid
BIZ35_RS16370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BIZ35_RS16380	COG0628	permease
BIZ35_RS16395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ35_RS16400	COG0765	amino acid transport
BIZ35_RS16405	COG0765	amino acid transport
BIZ35_RS16420	COG1733	regulation of RNA biosynthetic process
BIZ35_RS16435	COG0586	Pfam SNARE associated Golgi protein
BIZ35_RS16440	COG0586	Pfam SNARE associated Golgi protein
BIZ35_RS16460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BIZ35_RS16460	COG0646	methionine synthase
BIZ35_RS16465	COG1410	methionine synthase
BIZ35_RS16465	COG0646	methionine synthase
BIZ35_RS16495	COG3944	biosynthesis protein
BIZ35_RS16500	COG0489	protein tyrosine kinase activity
BIZ35_RS16505	COG4464	protein tyrosine phosphatase activity
BIZ35_RS16510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIZ35_RS16525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BIZ35_RS16560	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BIZ35_RS16560	COG0662	Cupin 2, conserved barrel domain protein
BIZ35_RS16565	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BIZ35_RS16595	COG1070	Carbohydrate kinase
BIZ35_RS16620	COG4193	domain, Protein
BIZ35_RS16635	COG5504	Zn-dependent protease
BIZ35_RS16640	COG2226	methyltransferase
BIZ35_RS16680	COG3716	PTS system mannose fructose sorbose family IID component
BIZ35_RS16685	COG3715	PTS system
BIZ35_RS16690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_RS16695	COG0363	glucosamine-6-phosphate deaminase activity
BIZ35_RS16700	COG2188	Transcriptional regulator
BIZ35_RS16705	COG1396	sequence-specific DNA binding
BIZ35_RS16715	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
BIZ35_RS16720	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIZ35_RS16725	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BIZ35_RS16725	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BIZ35_RS16735	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_RS16735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_RS16740	COG3715	PTS system
BIZ35_RS16745	COG3716	PTS system mannose fructose sorbose family IID component
BIZ35_RS16765	COG3414	Phosphotransferase system galactitol-specific IIB component
BIZ35_RS16770	COG3775	system Galactitol-specific IIC component
BIZ35_RS16780	COG1105	Belongs to the carbohydrate kinase PfkB family
BIZ35_RS16785	COG0235	Class ii aldolase
BIZ35_RS16805	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIZ35_RS16815	COG0145	ligase activity
BIZ35_RS16825	COG2315	Protein conserved in bacteria
BIZ35_RS16835	COG2333	competence protein COMEC
BIZ35_RS16835	COG0658	competence protein
BIZ35_RS16845	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BIZ35_RS16860	COG0531	amino acid
BIZ35_RS16870	COG1316	TRANSCRIPTIONal
BIZ35_RS16880	COG4989	oxidoreductase activity
BIZ35_RS16905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BIZ35_RS16910	COG2130	NADP-dependent
BIZ35_RS16925	COG3711	transcriptional antiterminator
BIZ35_RS16925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_RS16930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ35_RS16935	COG1447	Phosphotransferase system cellobiose-specific component IIA
BIZ35_RS16945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ35_RS16965	COG2814	Major facilitator Superfamily
BIZ35_RS16975	COG1609	Transcriptional regulator
BIZ35_RS16990	COG1174	glycine betaine transport
BIZ35_RS16995	COG1732	Glycine betaine
BIZ35_RS17000	COG1174	glycine betaine transport
BIZ35_RS17005	COG1125	glycine betaine transport
BIZ35_RS17005	COG0517	IMP dehydrogenase activity
BIZ35_RS17010	COG1510	regulation of RNA biosynthetic process
BIZ35_RS17015	COG0110	maltose O-acetyltransferase activity
BIZ35_RS17030	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS17045	COG4297	protein containing double-stranded beta helix domain
BIZ35_RS17055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIZ35_RS17070	COG0606	chelatase, subunit chli
BIZ35_RS17080	COG0371	Dehydrogenase
BIZ35_RS17085	COG2814	Major facilitator Superfamily
BIZ35_RS17090	COG1070	Carbohydrate kinase
BIZ35_RS17095	COG2115	Belongs to the xylose isomerase family
BIZ35_RS17110	COG0157	Belongs to the NadC ModD family
BIZ35_RS17115	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BIZ35_RS17120	COG1104	cysteine desulfurase activity
BIZ35_RS17130	COG2116	formate transmembrane transporter activity
BIZ35_RS17150	COG4720	Psort location CytoplasmicMembrane, score
BIZ35_RS17160	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS17165	COG2610	gluconate transmembrane transporter activity
BIZ35_RS17170	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_RS17180	COG3829	transcription factor binding
BIZ35_RS17180	COG3290	protein histidine kinase activity
BIZ35_RS17200	COG1960	acyl-CoA dehydrogenase activity
BIZ35_RS17205	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_RS17235	COG3344	reverse transcriptase
BIZ35_RS17240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ35_RS17245	COG0737	Belongs to the 5'-nucleotidase family
BIZ35_RS17250	COG1363	Peptidase, m42
BIZ35_RS17295	COG2972	Histidine kinase
BIZ35_RS17315	COG0531	amino acid
BIZ35_RS17325	COG1620	l-lactate permease
BIZ35_RS17330	COG2186	Transcriptional regulator
BIZ35_RS17375	COG0473	3-isopropylmalate dehydrogenase activity
BIZ35_RS17405	COG1447	Phosphotransferase system cellobiose-specific component IIA
BIZ35_RS17420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ35_RS17420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ35_RS17425	COG2723	6-phospho-beta-galactosidase activity
BIZ35_RS17430	COG3711	transcriptional antiterminator
BIZ35_RS17430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_RS17435	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BIZ35_RS17445	COG1131	(ABC) transporter
BIZ35_RS17455	COG0626	cystathionine gamma-synthase activity
BIZ35_RS17460	COG0626	cystathionine gamma-synthase activity
BIZ35_RS17480	COG1653	transport
BIZ35_RS17485	COG2207	Transcriptional regulator
BIZ35_RS17500	COG0604	alcohol dehydrogenase
BIZ35_RS17505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIZ35_RS17510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIZ35_RS17530	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_RS17535	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BIZ35_RS17545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BIZ35_RS17555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIZ35_RS17560	COG1316	TRANSCRIPTIONal
BIZ35_RS17575	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BIZ35_RS17585	COG1388	LysM domain
BIZ35_RS17585	COG3584	3D domain protein
BIZ35_RS17595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIZ35_RS17605	COG0011	TIGRFAM Protein of
BIZ35_RS17610	COG2706	6-phosphogluconolactonase activity
BIZ35_RS17625	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BIZ35_RS17625	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BIZ35_RS17630	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_RS17630	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_RS17640	COG3715	PTS system
BIZ35_RS17645	COG3716	PTS system mannose fructose sorbose family IID component