locus-tag	class	description
IR208_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IR208_RS00010	COG0592	DNA-directed DNA polymerase activity
IR208_RS00015	COG2501	S4 domain
IR208_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IR208_RS00030	COG0187	DNA topoisomerase II activity
IR208_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IR208_RS00040	COG3437	response regulator, receiver
IR208_RS00075	COG1982	Orn Lys Arg decarboxylase major
IR208_RS00085	COG3870	Protein conserved in bacteria
IR208_RS00090	COG1728	Protein conserved in bacteria
IR208_RS00095	COG0470	DNA polymerase III
IR208_RS00100	COG1774	PSP1 C-terminal conserved region
IR208_RS00105	COG4467	Involved in initiation control of chromosome replication
IR208_RS00110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IR208_RS00115	COG2827	Endonuclease containing a URI domain
IR208_RS00120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IR208_RS00125	COG2002	toxin-antitoxin pair type II binding
IR208_RS00135	COG0084	hydrolase, TatD family'
IR208_RS00145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IR208_RS00155	COG4466	Protein conserved in bacteria
IR208_RS00165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IR208_RS00170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IR208_RS00175	COG0251	oxidation-reduction process
IR208_RS00215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IR208_RS00220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IR208_RS00225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IR208_RS00230	COG0193	aminoacyl-tRNA hydrolase activity
IR208_RS00240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IR208_RS00245	COG2002	toxin-antitoxin pair type II binding
IR208_RS00250	COG2244	polysaccharide biosynthetic process
IR208_RS00255	COG3956	TIGRFAM MazG family protein
IR208_RS00260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IR208_RS00280	COG1098	S1 RNA binding domain
IR208_RS00290	COG2208	phosphoserine phosphatase activity
IR208_RS00295	COG2304	oxidoreductase activity
IR208_RS00300	COG0515	serine threonine protein kinase
IR208_RS00305	COG0037	tRNA processing
IR208_RS00310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IR208_RS00315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IR208_RS00320	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IR208_RS00325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IR208_RS00330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IR208_RS00335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IR208_RS00340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IR208_RS00345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IR208_RS00425	COG0517	IMP dehydrogenase activity
IR208_RS00425	COG0516	GMP reductase activity
IR208_RS00440	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IR208_RS00445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IR208_RS00460	COG1428	Deoxynucleoside kinase
IR208_RS00465	COG1428	Deoxynucleoside kinase
IR208_RS00470	COG1388	LysM domain
IR208_RS00470	COG3858	chitin binding
IR208_RS00480	COG0590	tRNA wobble adenosine to inosine editing
IR208_RS00490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IR208_RS00495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IR208_RS00500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IR208_RS00550	COG3880	PFAM UvrB UvrC protein
IR208_RS00555	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IR208_RS00560	COG0542	response to heat
IR208_RS00565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IR208_RS00570	COG4956	integral membrane protein (PIN domain superfamily)
IR208_RS00580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IR208_RS00585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IR208_RS00590	COG1045	serine acetyltransferase
IR208_RS00595	COG0215	cysteine-tRNA ligase activity
IR208_RS00605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IR208_RS00610	COG3688	RNA-binding protein containing a PIN domain
IR208_RS00620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IR208_RS00625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IR208_RS00630	COG0250	Participates in transcription elongation, termination and antitermination
IR208_RS00635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IR208_RS00640	COG0081	regulation of translation
IR208_RS00645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IR208_RS00655	COG2813	Specifically methylates the guanine in position
IR208_RS00660	COG0085	RNA polymerase activity
IR208_RS00670	COG1358	cellular component organization or biogenesis
IR208_RS00675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IR208_RS00680	COG0049	tRNA binding
IR208_RS00685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IR208_RS00690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IR208_RS00700	COG0051	transcription antitermination factor activity, RNA binding
IR208_RS00720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IR208_RS00725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IR208_RS00735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IR208_RS00740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IR208_RS00745	COG0255	Belongs to the universal ribosomal protein uL29 family
IR208_RS00750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IR208_RS00755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IR208_RS00760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IR208_RS00770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IR208_RS00775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IR208_RS00780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IR208_RS00785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IR208_RS00790	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IR208_RS00800	COG0200	Binds to the 23S rRNA
IR208_RS00805	COG0201	protein transport
IR208_RS00810	COG0563	adenylate kinase activity
IR208_RS00815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IR208_RS00820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IR208_RS00825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IR208_RS00830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IR208_RS00835	COG0202	RNA polymerase activity
IR208_RS00840	COG0203	ribosomal protein L17
IR208_RS00845	COG1122	ATPase activity
IR208_RS00850	COG1122	ATPase activity
IR208_RS00855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IR208_RS00865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IR208_RS00870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IR208_RS00875	COG0753	catalase activity
IR208_RS00885	COG2046	Belongs to the sulfate adenylyltransferase family
IR208_RS00890	COG0529	Catalyzes the synthesis of activated sulfate
IR208_RS00895	COG0833	amino acid
IR208_RS00905	COG0860	N-Acetylmuramoyl-L-alanine amidase
IR208_RS00910	COG0489	protein tyrosine kinase activity
IR208_RS00920	COG2194	sulfuric ester hydrolase activity
IR208_RS00945	COG0662	Cupin 2, conserved barrel domain protein
IR208_RS00955	COG0726	polysaccharide deacetylase
IR208_RS00965	COG1271	oxidase subunit
IR208_RS00970	COG1294	oxidase, subunit
IR208_RS00975	COG4988	ABC transporter
IR208_RS00980	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IR208_RS01055	COG1595	DNA-templated transcription, initiation
IR208_RS01060	COG5662	AntiSigma factor
IR208_RS01065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IR208_RS01070	COG4856	YbbR-like protein
IR208_RS01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IR208_RS01080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IR208_RS01105	COG2814	Major facilitator Superfamily
IR208_RS01125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IR208_RS01130	COG0840	transmembrane signaling receptor activity
IR208_RS01145	COG1695	Transcriptional regulator
IR208_RS01150	COG0840	transmembrane signaling receptor activity
IR208_RS01155	COG0477	Major facilitator Superfamily
IR208_RS01205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IR208_RS01210	COG2814	Major facilitator Superfamily
IR208_RS01220	COG0519	Catalyzes the synthesis of GMP from XMP
IR208_RS01245	COG0477	Major facilitator Superfamily
IR208_RS01245	COG2814	Major facilitator Superfamily
IR208_RS01280	COG3425	synthase
IR208_RS01285	COG0183	Belongs to the thiolase family
IR208_RS01290	COG0183	Belongs to the thiolase family
IR208_RS01310	COG1125	glycine betaine transport
IR208_RS01310	COG0517	IMP dehydrogenase activity
IR208_RS01315	COG1174	glycine betaine transport
IR208_RS01320	COG2190	(PTS) system
IR208_RS01325	COG1263	PTS System
IR208_RS01325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_RS01330	COG0366	Alpha amylase catalytic
IR208_RS01335	COG2188	Transcriptional regulator
IR208_RS01345	COG1070	Carbohydrate kinase
IR208_RS01355	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IR208_RS01360	COG0716	FMN binding
IR208_RS01365	COG0322	excinuclease ABC activity
IR208_RS01375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IR208_RS01385	COG2608	mercury ion transmembrane transporter activity
IR208_RS01390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR208_RS01400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR208_RS01405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IR208_RS01410	COG0463	Glycosyl transferase, family 2
IR208_RS01440	COG2076	Multidrug Resistance protein
IR208_RS01445	COG2076	Multidrug Resistance protein
IR208_RS01455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR208_RS01460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR208_RS01465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IR208_RS01470	COG1120	ATPase activity
IR208_RS01495	COG0217	transcriptional regulatory protein
IR208_RS01500	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_RS01510	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS01520	COG1309	transcriptional regulator
IR208_RS01535	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS01545	COG0765	amino acid transport
IR208_RS01555	COG5434	Belongs to the glycosyl hydrolase 28 family
IR208_RS01560	COG0175	sulfate reduction
IR208_RS01580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IR208_RS01585	COG0371	Dehydrogenase
IR208_RS01590	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_RS01605	COG0697	spore germination
IR208_RS01625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IR208_RS01635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IR208_RS01650	COG0702	epimerase
IR208_RS01670	COG2213	PTS system mannitol-specific
IR208_RS01670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_RS01675	COG3711	transcriptional antiterminator
IR208_RS01680	COG0246	Mannitol dehydrogenase
IR208_RS01685	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IR208_RS01705	COG2848	UPF0210 protein
IR208_RS01710	COG1609	Transcriptional regulator
IR208_RS01725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR208_RS01740	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IR208_RS01750	COG5577	PFAM Coat F domain
IR208_RS01760	COG0667	Aldo Keto reductase
IR208_RS01770	COG1113	amino acid transport
IR208_RS01775	COG3104	oligopeptide transport
IR208_RS01780	COG0833	amino acid
IR208_RS01790	COG3842	ATPase activity
IR208_RS01795	COG1176	ABC-type spermidine putrescine transport system, permease component I
IR208_RS01815	COG0531	amino acid
IR208_RS01820	COG1556	Lactate utilization protein
IR208_RS01825	COG1139	Iron-sulfur cluster binding protein
IR208_RS01830	COG0247	lactate metabolic process
IR208_RS01840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IR208_RS01845	COG1454	alcohol dehydrogenase
IR208_RS01855	COG1953	Uracil, thiamine, allantoin
IR208_RS01880	COG0531	amino acid
IR208_RS01885	COG1979	alcohol dehydrogenase
IR208_RS01890	COG0004	ammonium transporteR
IR208_RS01895	COG3290	protein histidine kinase activity
IR208_RS01900	COG4565	transcriptional regulatory protein
IR208_RS01905	COG2851	Citrate transporter
IR208_RS01910	COG0463	Glycosyl transferase, family 2
IR208_RS01915	COG3973	AAA domain
IR208_RS01940	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IR208_RS01945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IR208_RS01950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IR208_RS01955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IR208_RS01960	COG1301	dicarboxylic acid transport
IR208_RS01965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IR208_RS01980	COG1902	pentaerythritol trinitrate reductase activity
IR208_RS02000	COG0423	glycine-tRNA ligase activity
IR208_RS02005	COG0531	amino acid
IR208_RS02015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IR208_RS02020	COG0628	permease
IR208_RS02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR208_RS02040	COG0765	amino acid transport
IR208_RS02045	COG0765	amino acid transport
IR208_RS02060	COG1733	regulation of RNA biosynthetic process
IR208_RS02070	COG0586	Pfam SNARE associated Golgi protein
IR208_RS02075	COG0586	Pfam SNARE associated Golgi protein
IR208_RS02090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IR208_RS02090	COG0646	methionine synthase
IR208_RS02095	COG1410	methionine synthase
IR208_RS02095	COG0646	methionine synthase
IR208_RS02120	COG3944	biosynthesis protein
IR208_RS02125	COG0489	protein tyrosine kinase activity
IR208_RS02130	COG4464	protein tyrosine phosphatase activity
IR208_RS02135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IR208_RS02150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IR208_RS02185	COG0662	Cupin 2, conserved barrel domain protein
IR208_RS02185	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IR208_RS02190	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IR208_RS02220	COG1070	Carbohydrate kinase
IR208_RS02250	COG4193	domain, Protein
IR208_RS02270	COG5504	Zn-dependent protease
IR208_RS02275	COG2226	methyltransferase
IR208_RS02310	COG3716	PTS system mannose fructose sorbose family IID component
IR208_RS02315	COG3715	PTS system
IR208_RS02320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_RS02325	COG0363	glucosamine-6-phosphate deaminase activity
IR208_RS02330	COG2188	Transcriptional regulator
IR208_RS02335	COG1396	sequence-specific DNA binding
IR208_RS02345	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
IR208_RS02350	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IR208_RS02355	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IR208_RS02355	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IR208_RS02365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_RS02365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_RS02370	COG3715	PTS system
IR208_RS02375	COG3716	PTS system mannose fructose sorbose family IID component
IR208_RS02395	COG3414	Phosphotransferase system galactitol-specific IIB component
IR208_RS02400	COG3775	system Galactitol-specific IIC component
IR208_RS02410	COG1105	Belongs to the carbohydrate kinase PfkB family
IR208_RS02415	COG0235	Class ii aldolase
IR208_RS02435	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IR208_RS02445	COG0145	ligase activity
IR208_RS02455	COG2315	Protein conserved in bacteria
IR208_RS02465	COG0658	competence protein
IR208_RS02465	COG2333	competence protein COMEC
IR208_RS02490	COG0531	amino acid
IR208_RS02500	COG1316	TRANSCRIPTIONal
IR208_RS02510	COG4989	oxidoreductase activity
IR208_RS02535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IR208_RS02540	COG2130	NADP-dependent
IR208_RS02550	COG3711	transcriptional antiterminator
IR208_RS02550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_RS02555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IR208_RS02560	COG1447	Phosphotransferase system cellobiose-specific component IIA
IR208_RS02570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IR208_RS02595	COG2814	Major facilitator Superfamily
IR208_RS02605	COG1609	Transcriptional regulator
IR208_RS02615	COG1174	glycine betaine transport
IR208_RS02620	COG1732	Glycine betaine
IR208_RS02625	COG1174	glycine betaine transport
IR208_RS02630	COG1125	glycine betaine transport
IR208_RS02630	COG0517	IMP dehydrogenase activity
IR208_RS02635	COG1510	regulation of RNA biosynthetic process
IR208_RS02640	COG0110	maltose O-acetyltransferase activity
IR208_RS02670	COG4297	protein containing double-stranded beta helix domain
IR208_RS02680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR208_RS02690	COG0606	chelatase, subunit chli
IR208_RS02705	COG0371	Dehydrogenase
IR208_RS02710	COG2814	Major facilitator Superfamily
IR208_RS02715	COG1070	Carbohydrate kinase
IR208_RS02720	COG2115	Belongs to the xylose isomerase family
IR208_RS02735	COG0157	Belongs to the NadC ModD family
IR208_RS02740	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IR208_RS02745	COG1104	cysteine desulfurase activity
IR208_RS02755	COG2116	formate transmembrane transporter activity
IR208_RS02775	COG4720	Psort location CytoplasmicMembrane, score
IR208_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS02790	COG2610	gluconate transmembrane transporter activity
IR208_RS02795	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS02805	COG3829	transcription factor binding
IR208_RS02805	COG3290	protein histidine kinase activity
IR208_RS02820	COG1960	acyl-CoA dehydrogenase activity
IR208_RS02850	COG3344	reverse transcriptase
IR208_RS02855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR208_RS02860	COG0737	Belongs to the 5'-nucleotidase family
IR208_RS02865	COG1363	Peptidase, m42
IR208_RS02905	COG2972	Histidine kinase
IR208_RS02925	COG0531	amino acid
IR208_RS02935	COG1620	l-lactate permease
IR208_RS02940	COG2186	Transcriptional regulator
IR208_RS02970	COG0473	3-isopropylmalate dehydrogenase activity
IR208_RS03005	COG1447	Phosphotransferase system cellobiose-specific component IIA
IR208_RS03020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IR208_RS03020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IR208_RS03025	COG2723	6-phospho-beta-galactosidase activity
IR208_RS03030	COG3711	transcriptional antiterminator
IR208_RS03030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_RS03035	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IR208_RS03045	COG1131	(ABC) transporter
IR208_RS03055	COG0626	cystathionine gamma-synthase activity
IR208_RS03060	COG0626	cystathionine gamma-synthase activity
IR208_RS03080	COG1653	transport
IR208_RS03085	COG2207	Transcriptional regulator
IR208_RS03100	COG0604	alcohol dehydrogenase
IR208_RS03105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IR208_RS03110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IR208_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS03135	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IR208_RS03145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IR208_RS03155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IR208_RS03160	COG1316	TRANSCRIPTIONal
IR208_RS03175	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IR208_RS03185	COG3584	3D domain protein
IR208_RS03185	COG1388	LysM domain
IR208_RS03195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IR208_RS03205	COG0011	TIGRFAM Protein of
IR208_RS03210	COG2706	6-phosphogluconolactonase activity
IR208_RS03220	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IR208_RS03220	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IR208_RS03225	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_RS03225	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_RS03235	COG3715	PTS system
IR208_RS03240	COG3716	PTS system mannose fructose sorbose family IID component
IR208_RS03255	COG2079	MmgE PrpD family protein
IR208_RS03260	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IR208_RS03270	COG0154	amidase activity
IR208_RS03280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR208_RS03285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR208_RS03290	COG1116	anion transmembrane transporter activity
IR208_RS03295	COG0083	homoserine kinase activity
IR208_RS03300	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IR208_RS03305	COG0460	homoserine dehydrogenase
IR208_RS03310	COG0010	Belongs to the arginase family
IR208_RS03320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IR208_RS03325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IR208_RS03335	COG4145	pantothenate transmembrane transporter activity
IR208_RS03350	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS03350	COG1454	alcohol dehydrogenase
IR208_RS03365	COG1388	LysM domain
IR208_RS03365	COG0791	NLP P60 protein
IR208_RS03370	COG0024	Methionine aminopeptidase
IR208_RS03375	COG1268	BioY protein
IR208_RS03390	COG1960	acyl-CoA dehydrogenase activity
IR208_RS03395	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS03400	COG2746	aminoglycoside 3-N-acetyltransferase activity
IR208_RS03405	COG2244	polysaccharide biosynthetic process
IR208_RS03410	COG0589	response to stress
IR208_RS03425	COG0535	radical SAM domain protein
IR208_RS03430	COG0457	Tetratricopeptide repeat
IR208_RS03445	COG1609	Transcriptional regulator
IR208_RS03455	COG0561	phosphatase activity
IR208_RS03490	COG0656	L-ascorbic acid biosynthetic process
IR208_RS03495	COG0431	NADPH-dependent FMN reductase
IR208_RS03500	COG0420	3'-5' exonuclease activity
IR208_RS03505	COG4717	serine-type aminopeptidase activity
IR208_RS03510	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR208_RS03515	COG0534	Mate efflux family protein
IR208_RS03520	COG1664	Polymer-forming cytoskeletal
IR208_RS03530	COG0789	Transcriptional regulator
IR208_RS03535	COG0436	Aminotransferase
IR208_RS03540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IR208_RS03560	COG2226	methyltransferase
IR208_RS03580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IR208_RS03605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IR208_RS03610	COG1113	amino acid transport
IR208_RS03615	COG2814	Major facilitator Superfamily
IR208_RS03630	COG2409	Drug exporters of the RND superfamily
IR208_RS03630	COG1033	growth of symbiont in host cell
IR208_RS03640	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IR208_RS03655	COG1960	acyl-CoA dehydrogenase activity
IR208_RS03670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IR208_RS03675	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IR208_RS03685	COG1609	Transcriptional regulator
IR208_RS03700	COG2996	Protein conserved in bacteria
IR208_RS03705	COG0346	lactoylglutathione lyase activity
IR208_RS03710	COG1482	cell wall glycoprotein biosynthetic process
IR208_RS03720	COG0477	Major facilitator Superfamily
IR208_RS03725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IR208_RS03735	COG2188	Transcriptional regulator
IR208_RS03740	COG0791	NLP P60 protein
IR208_RS03740	COG1388	LysM domain
IR208_RS03750	COG0768	penicillin binding
IR208_RS03755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IR208_RS03760	COG1739	Uncharacterized protein family UPF0029
IR208_RS03770	COG2197	response regulator
IR208_RS03775	COG0531	amino acid
IR208_RS03780	COG1307	EDD domain protein, DegV family
IR208_RS03785	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IR208_RS03790	COG1040	competence protein
IR208_RS03800	COG2747	anti-sigma28 factor FlgM
IR208_RS03810	COG4786	Flagellar basal body rod
IR208_RS03810	COG1256	bacterial-type flagellum assembly
IR208_RS03815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IR208_RS03825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IR208_RS03845	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IR208_RS03850	COG1285	pathogenesis
IR208_RS03855	COG0647	UMP catabolic process
IR208_RS03865	COG2271	Major facilitator Superfamily
IR208_RS03870	COG1113	amino acid transport
IR208_RS03880	COG1113	amino acid transport
IR208_RS03885	COG1067	ATP-dependent peptidase activity
IR208_RS03895	COG2094	Belongs to the DNA glycosylase MPG family
IR208_RS03905	COG1334	flagellar protein FlaG
IR208_RS03910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IR208_RS03915	COG1516	flagellar protein fliS
IR208_RS03935	COG0653	protein targeting
IR208_RS03945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IR208_RS03955	COG2884	Cell division ATP-binding protein ftsE
IR208_RS03960	COG2177	Part of the ABC transporter FtsEX involved in
IR208_RS03965	COG0739	heme binding
IR208_RS03980	COG0460	homoserine dehydrogenase
IR208_RS03985	COG0793	Belongs to the peptidase S41A family
IR208_RS03985	COG3409	Peptidoglycan-binding domain 1 protein
IR208_RS03995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IR208_RS04000	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR208_RS04005	COG4605	iron ion homeostasis
IR208_RS04010	COG4604	ABC transporter, ATP-binding protein
IR208_RS04015	COG4607	ABC-type enterochelin transport system periplasmic component
IR208_RS04030	COG0745	RESPONSE REGULATOR receiver
IR208_RS04035	COG5002	protein histidine kinase activity
IR208_RS04040	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IR208_RS04055	COG0573	inorganic phosphate transmembrane transporter activity
IR208_RS04060	COG0581	inorganic phosphate transmembrane transporter activity
IR208_RS04070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IR208_RS04110	COG0556	nucleotide-excision repair
IR208_RS04115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IR208_RS04120	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IR208_RS04130	COG0463	Glycosyl transferase, family 2
IR208_RS04140	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IR208_RS04145	COG0463	Glycosyl transferase, family 2
IR208_RS04145	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IR208_RS04150	COG1682	transport, permease protein
IR208_RS04155	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IR208_RS04160	COG3595	metallopeptidase activity
IR208_RS04170	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IR208_RS04175	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IR208_RS04180	COG0546	phosphoglycolate phosphatase activity
IR208_RS04185	COG0110	maltose O-acetyltransferase activity
IR208_RS04190	COG0457	Tetratricopeptide repeat
IR208_RS04195	COG0492	ferredoxin-NADP+ reductase activity
IR208_RS04200	COG1051	belongs to the nudix hydrolase family
IR208_RS04205	COG1660	Displays ATPase and GTPase activities
IR208_RS04210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IR208_RS04215	COG1481	regulation of sporulation
IR208_RS04220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_RS04255	COG3842	ATPase activity
IR208_RS04260	COG2508	Transcriptional regulator
IR208_RS04270	COG0189	ligase activity
IR208_RS04275	COG0189	ligase activity
IR208_RS04285	COG4399	Belongs to the UPF0754 family
IR208_RS04295	COG0561	phosphatase activity
IR208_RS04300	COG1024	Enoyl-CoA hydratase
IR208_RS04310	COG0861	Integral membrane protein TerC family
IR208_RS04315	COG0701	Predicted permease
IR208_RS04320	COG3689	TIGRFAM TIGR03943 family protein
IR208_RS04325	COG0420	3'-5' exonuclease activity
IR208_RS04330	COG4717	serine-type aminopeptidase activity
IR208_RS04335	COG3481	metal-dependent phosphohydrolase, HD sub domain
IR208_RS04345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IR208_RS04360	COG1846	Transcriptional regulator
IR208_RS04380	COG0537	adenosine 5'-monophosphoramidase activity
IR208_RS04385	COG1131	(ABC) transporter
IR208_RS04390	COG4473	ABC transporter
IR208_RS04395	COG1473	amidohydrolase
IR208_RS04400	COG3069	C4-dicarboxylate transmembrane transporter activity
IR208_RS04405	COG2329	Antibiotic biosynthesis monooxygenase
IR208_RS04410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IR208_RS04415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IR208_RS04420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IR208_RS04425	COG1309	transcriptional regulator
IR208_RS04430	COG1511	domain protein
IR208_RS04435	COG2190	(PTS) system
IR208_RS04435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_RS04435	COG2190	(PTS) system
IR208_RS04435	COG1263	PTS System
IR208_RS04435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_RS04435	COG1263	PTS System
IR208_RS04440	COG1349	DNA-binding transcription factor activity
IR208_RS04450	COG0697	spore germination
IR208_RS04455	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS04460	COG1999	signal sequence binding
IR208_RS04475	COG0095	Lipoate-protein ligase
IR208_RS04480	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_RS04485	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IR208_RS04495	COG0501	Belongs to the peptidase M48B family
IR208_RS04515	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IR208_RS04520	COG1074	ATP-dependent DNA helicase activity
IR208_RS04555	COG2311	Membrane
IR208_RS04560	COG0179	Fumarylacetoacetate (FAA) hydrolase
IR208_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS04580	COG1307	EDD domain protein, DegV family
IR208_RS04600	COG0561	phosphatase activity
IR208_RS04605	COG2151	metal-sulfur cluster biosynthetic enzyme
IR208_RS04635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IR208_RS04640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR208_RS04655	COG4608	Belongs to the ABC transporter superfamily
IR208_RS04660	COG0601	transmembrane transport
IR208_RS04670	COG0747	negative chemotaxis
IR208_RS04680	COG0180	Tryptophanyl-tRNA synthetase
IR208_RS04695	COG4166	transmembrane transport
IR208_RS04700	COG0601	transmembrane transport
IR208_RS04705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR208_RS04710	COG0444	Belongs to the ABC transporter superfamily
IR208_RS04715	COG4608	Belongs to the ABC transporter superfamily
IR208_RS04720	COG1393	Belongs to the ArsC family
IR208_RS04725	COG4862	establishment of competence for transformation
IR208_RS04730	COG4469	Competence protein
IR208_RS04735	COG1164	Oligoendopeptidase f
IR208_RS04745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IR208_RS04750	COG2346	COG2346, Truncated hemoglobins
IR208_RS04755	COG0741	lytic transglycosylase activity
IR208_RS04760	COG4116	CYTH
IR208_RS04770	COG2357	RelA SpoT domain protein
IR208_RS04780	COG0564	pseudouridine synthase activity
IR208_RS04785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IR208_RS04790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IR208_RS04825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IR208_RS04850	COG2153	protein acetylation
IR208_RS04860	COG2382	esterase
IR208_RS04890	COG1940	carbohydrate kinase activity
IR208_RS04900	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS04905	COG4152	abc transporter atp-binding protein
IR208_RS04910	COG1668	transmembrane transport
IR208_RS04920	COG3579	cysteine-type endopeptidase activity
IR208_RS04980	COG1247	-acetyltransferase
IR208_RS05000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR208_RS05005	COG2059	Chromate
IR208_RS05010	COG2059	Chromate
IR208_RS05015	COG1522	sequence-specific DNA binding
IR208_RS05030	COG0154	amidase activity
IR208_RS05150	COG4974	Belongs to the 'phage' integrase family
IR208_RS05165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IR208_RS05170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IR208_RS05195	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS05210	COG1959	2 iron, 2 sulfur cluster binding
IR208_RS05220	COG0730	response to heat
IR208_RS05225	COG0783	Belongs to the Dps family
IR208_RS05230	COG0673	inositol 2-dehydrogenase activity
IR208_RS05235	COG3852	Histidine kinase
IR208_RS05240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IR208_RS05250	COG0861	Integral membrane protein TerC family
IR208_RS05270	COG5002	protein histidine kinase activity
IR208_RS05275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IR208_RS05290	COG0542	response to heat
IR208_RS05295	COG3949	Membrane
IR208_RS05305	COG4873	Protein conserved in bacteria
IR208_RS05315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_RS05330	COG2084	Dehydrogenase
IR208_RS05335	COG0436	Aminotransferase
IR208_RS05340	COG0835	chemotaxis
IR208_RS05340	COG0784	Response regulator, receiver
IR208_RS05350	COG1033	growth of symbiont in host cell
IR208_RS05350	COG2409	Drug exporters of the RND superfamily
IR208_RS05365	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS05375	COG4703	Protein of unknown function (DUF1797)
IR208_RS05380	COG0517	IMP dehydrogenase activity
IR208_RS05385	COG0583	DNA-binding transcription factor activity
IR208_RS05390	COG2171	N-acyltransferase activity
IR208_RS05395	COG1473	amidohydrolase
IR208_RS05405	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IR208_RS05450	COG1982	Orn Lys Arg decarboxylase major
IR208_RS05460	COG4476	Belongs to the UPF0223 family
IR208_RS05475	COG0483	inositol monophosphate 1-phosphatase activity
IR208_RS05485	COG1217	gtp-binding protein TYPA
IR208_RS05495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IR208_RS05500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IR208_RS05505	COG4838	Belongs to the UPF0358 family
IR208_RS05510	COG0772	Belongs to the SEDS family
IR208_RS05515	COG1612	heme a metabolic process
IR208_RS05520	COG0109	protoheme IX farnesyltransferase activity
IR208_RS05540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IR208_RS05545	COG3336	cytochrome c oxidase
IR208_RS05555	COG2340	Cysteine-rich secretory protein family
IR208_RS05560	COG2050	protein possibly involved in aromatic compounds catabolism
IR208_RS05580	COG3679	Belongs to the UPF0342 family
IR208_RS05585	COG4471	UPF0298 protein
IR208_RS05595	COG0742	ribosomal rna small subunit methyltransferase
IR208_RS05600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IR208_RS05605	COG3314	Sporulation integral membrane protein YlbJ
IR208_RS05610	COG1752	Esterase of the alpha-beta hydrolase superfamily
IR208_RS05615	COG3480	Lon protease (S16) C-terminal proteolytic domain
IR208_RS05620	COG1323	Belongs to the UPF0348 family
IR208_RS05625	COG1399	metal-binding, possibly nucleic acid-binding protein
IR208_RS05630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IR208_RS05640	COG0454	-acetyltransferase
IR208_RS05645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IR208_RS05650	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IR208_RS05655	COG2001	Belongs to the MraZ family
IR208_RS05660	COG0275	rRNA processing
IR208_RS05665	COG4839	cell division protein FtsL
IR208_RS05670	COG0768	penicillin binding
IR208_RS05675	COG0768	penicillin binding
IR208_RS05690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IR208_RS05695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IR208_RS05700	COG0772	Belongs to the SEDS family
IR208_RS05705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IR208_RS05710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IR208_RS05715	COG0849	cell division
IR208_RS05720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IR208_RS05730	COG1191	sigma factor activity
IR208_RS05735	COG1191	sigma factor activity
IR208_RS05740	COG1873	PFAM PRC-barrel domain
IR208_RS05745	COG1388	LysM domain
IR208_RS05745	COG3584	3D domain protein
IR208_RS05755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IR208_RS05760	COG1799	cell septum assembly
IR208_RS05765	COG0762	integral membrane protein
IR208_RS05770	COG2302	S4 RNA-binding domain
IR208_RS05775	COG3599	regulation of cell shape
IR208_RS05790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IR208_RS05795	COG0564	pseudouridine synthase activity
IR208_RS05800	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IR208_RS05805	COG0540	Belongs to the ATCase OTCase family
IR208_RS05810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IR208_RS05825	COG0543	2 iron, 2 sulfur cluster binding
IR208_RS05830	COG0167	dihydroorotate dehydrogenase activity
IR208_RS05835	COG0284	orotidine-5'-phosphate decarboxylase activity
IR208_RS05840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IR208_RS05855	COG2207	Transcriptional regulator
IR208_RS05855	COG1917	Cupin 2, conserved barrel domain protein
IR208_RS05860	COG1070	Carbohydrate kinase
IR208_RS05865	COG4806	L-rhamnose isomerase
IR208_RS05870	COG0235	Class ii aldolase
IR208_RS05875	COG1454	alcohol dehydrogenase
IR208_RS05880	COG1803	Methylglyoxal synthase
IR208_RS05885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IR208_RS05890	COG0477	Major facilitator Superfamily
IR208_RS05895	COG0477	Major facilitator Superfamily
IR208_RS05900	COG1309	transcriptional regulator
IR208_RS05915	COG0628	permease
IR208_RS05920	COG0561	phosphatase activity
IR208_RS05950	COG0720	synthase
IR208_RS05960	COG0385	Bile acid
IR208_RS05970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IR208_RS05975	COG1561	YicC-like family, N-terminal region
IR208_RS05980	COG2052	Domain of unknown function (DUF370)
IR208_RS05985	COG0194	GDP metabolic process
IR208_RS05990	COG1758	RNA polymerase activity
IR208_RS05995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IR208_RS06000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IR208_RS06005	COG0242	peptide deformylase activity
IR208_RS06010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IR208_RS06015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IR208_RS06015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IR208_RS06020	COG0631	protein serine/threonine phosphatase activity
IR208_RS06025	COG2815	serine threonine protein kinase
IR208_RS06025	COG0515	serine threonine protein kinase
IR208_RS06035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IR208_RS06040	COG1564	THIamine pyrophosphokinase
IR208_RS06050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IR208_RS06060	COG1302	Protein conserved in bacteria
IR208_RS06065	COG1461	Dihydroxyacetone kinase
IR208_RS06070	COG1760	l-serine dehydratase
IR208_RS06075	COG1760	l-serine dehydratase
IR208_RS06080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IR208_RS06085	COG1349	DNA-binding transcription factor activity
IR208_RS06090	COG0416	fatty acid biosynthetic process
IR208_RS06095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IR208_RS06100	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS06110	COG0571	ribonuclease III activity
IR208_RS06115	COG1196	nuclear chromosome segregation
IR208_RS06120	COG0552	protein localization to endoplasmic reticulum
IR208_RS06125	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IR208_RS06130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IR208_RS06140	COG1837	Belongs to the UPF0109 family
IR208_RS06150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IR208_RS06155	COG0336	Belongs to the RNA methyltransferase TrmD family
IR208_RS06170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IR208_RS06185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IR208_RS06190	COG0045	succinate-CoA ligase (ADP-forming) activity
IR208_RS06195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IR208_RS06200	COG0758	DNA mediated transformation
IR208_RS06205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IR208_RS06210	COG4974	Belongs to the 'phage' integrase family
IR208_RS06215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IR208_RS06225	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IR208_RS06230	COG1815	bacterial-type flagellum-dependent cell motility
IR208_RS06235	COG1558	bacterial-type flagellum-dependent cell motility
IR208_RS06240	COG1677	Flagellar hook-basal body complex protein FliE
IR208_RS06245	COG1766	The M ring may be actively involved in energy transduction
IR208_RS06250	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IR208_RS06255	COG1317	bacterial-type flagellum organization
IR208_RS06260	COG1157	protein secretion by the type III secretion system
IR208_RS06265	COG2882	bacterial-type flagellum organization
IR208_RS06280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IR208_RS06290	COG4786	Flagellar basal body rod
IR208_RS06300	COG1580	Controls the rotational direction of flagella during chemotaxis
IR208_RS06305	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IR208_RS06310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IR208_RS06310	COG1776	CheC inhibitor of MCP methylation
IR208_RS06315	COG2201	protein-glutamate methylesterase activity
IR208_RS06320	COG3190	flagellar
IR208_RS06325	COG1338	Plays a role in the flagellum-specific transport system
IR208_RS06330	COG1987	bacterial-type flagellum assembly
IR208_RS06340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IR208_RS06345	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IR208_RS06350	COG1419	protein localization to endoplasmic reticulum
IR208_RS06355	COG0455	bacterial-type flagellum organization
IR208_RS06360	COG2201	protein-glutamate methylesterase activity
IR208_RS06365	COG0643	Histidine kinase
IR208_RS06365	COG2198	Histidine kinase
IR208_RS06370	COG0835	chemotaxis
IR208_RS06375	COG1776	CheC inhibitor of MCP methylation
IR208_RS06380	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IR208_RS06385	COG1191	sigma factor activity
IR208_RS06395	COG0052	Belongs to the universal ribosomal protein uS2 family
IR208_RS06400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IR208_RS06405	COG0528	UMP kinase activity
IR208_RS06410	COG0233	cytoplasmic translational termination
IR208_RS06415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IR208_RS06420	COG4589	Belongs to the CDS family
IR208_RS06430	COG0750	zinc metalloprotease
IR208_RS06435	COG0442	prolyl-tRNA aminoacylation
IR208_RS06440	COG2176	DNA-directed DNA polymerase activity
IR208_RS06445	COG0779	Required for maturation of 30S ribosomal subunits
IR208_RS06450	COG0195	Participates in both transcription termination and antitermination
IR208_RS06455	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IR208_RS06460	COG1358	cellular component organization or biogenesis
IR208_RS06470	COG1550	Protein conserved in bacteria
IR208_RS06475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IR208_RS06480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IR208_RS06485	COG0196	riboflavin kinase activity
IR208_RS06490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IR208_RS06495	COG1185	polyribonucleotide nucleotidyltransferase activity
IR208_RS06500	COG0726	polysaccharide deacetylase
IR208_RS06505	COG0612	Peptidase, M16
IR208_RS06510	COG1873	PFAM PRC-barrel domain
IR208_RS06515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IR208_RS06520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IR208_RS06525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IR208_RS06530	COG0527	aspartate kinase activity
IR208_RS06540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IR208_RS06545	COG0740	serine-type endopeptidase activity
IR208_RS06555	COG4980	gas vesicle protein
IR208_RS06555	COG1674	ftsk spoiiie
IR208_RS06560	COG1744	ABC transporter substrate-binding protein PnrA-like
IR208_RS06570	COG4603	Belongs to the binding-protein-dependent transport system permease family
IR208_RS06575	COG1079	Belongs to the binding-protein-dependent transport system permease family
IR208_RS06580	COG0612	Peptidase, M16
IR208_RS06585	COG0612	Peptidase, M16
IR208_RS06590	COG0300	oxidoreductase activity
IR208_RS06605	COG1426	Protein conserved in bacteria
IR208_RS06610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IR208_RS06615	COG1058	Belongs to the CinA family
IR208_RS06615	COG1546	Belongs to the CinA family
IR208_RS06625	COG1418	mRNA catabolic process
IR208_RS06630	COG1692	metallophosphoesterase
IR208_RS06635	COG2359	stage V sporulation protein S
IR208_RS06640	COG0826	peptidase U32
IR208_RS06645	COG0826	peptidase U32
IR208_RS06655	COG3829	transcription factor binding
IR208_RS06660	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS06670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IR208_RS06675	COG4550	Control of competence regulator ComK, YlbF/YmcA
IR208_RS06685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IR208_RS06690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IR208_RS06720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IR208_RS06730	COG0464	growth
IR208_RS06735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IR208_RS06740	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IR208_RS06745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR208_RS06765	COG1321	iron dependent repressor
IR208_RS06770	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IR208_RS06780	COG1418	mRNA catabolic process
IR208_RS06785	COG0488	(ABC) transporter
IR208_RS06790	COG1413	lyase activity
IR208_RS06805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IR208_RS06810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IR208_RS06815	COG1272	protein, Hemolysin III
IR208_RS06820	COG2755	lipolytic protein G-D-S-L family
IR208_RS06830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IR208_RS06830	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IR208_RS06835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR208_RS06840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR208_RS06850	COG0840	transmembrane signaling receptor activity
IR208_RS06855	COG4479	Belongs to the UPF0346 family
IR208_RS06875	COG1876	peptidase activity
IR208_RS06880	COG3409	Peptidoglycan-binding domain 1 protein
IR208_RS06880	COG0793	Belongs to the peptidase S41A family
IR208_RS06885	COG1846	Transcriptional regulator
IR208_RS06890	COG2340	Cysteine-rich secretory protein family
IR208_RS06895	COG0534	Mate efflux family protein
IR208_RS06910	COG1793	dna ligase
IR208_RS06910	COG3285	dna ligase
IR208_RS06915	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IR208_RS06920	COG0671	phosphoesterase, PA-phosphatase related
IR208_RS06925	COG1368	sulfuric ester hydrolase activity
IR208_RS06940	COG1331	Highly conserved protein containing a thioredoxin domain
IR208_RS06945	COG2814	Major facilitator Superfamily
IR208_RS06950	COG0745	RESPONSE REGULATOR receiver
IR208_RS06955	COG5002	protein histidine kinase activity
IR208_RS06965	COG0567	Dehydrogenase, E1 component
IR208_RS06970	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR208_RS06975	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS06990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IR208_RS07000	COG1054	Belongs to the UPF0176 family
IR208_RS07005	COG2135	peptidase activity
IR208_RS07015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR208_RS07020	COG0516	GMP reductase activity
IR208_RS07020	COG0517	IMP dehydrogenase activity
IR208_RS07025	COG0723	plastoquinol--plastocyanin reductase activity
IR208_RS07025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR208_RS07030	COG3584	3D domain protein
IR208_RS07030	COG1388	LysM domain
IR208_RS07035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IR208_RS07040	COG1113	amino acid transport
IR208_RS07045	COG1280	lysine exporter protein (LysE YggA)
IR208_RS07050	COG0598	Magnesium transport protein CorA
IR208_RS07065	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IR208_RS07070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IR208_RS07075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IR208_RS07080	COG0131	Imidazoleglycerol-phosphate dehydratase
IR208_RS07085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IR208_RS07095	COG0107	imidazoleglycerol-phosphate synthase activity
IR208_RS07100	COG0140	phosphoribosyl-ATP diphosphatase activity
IR208_RS07100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IR208_RS07110	COG2391	methyltransferase activity
IR208_RS07115	COG2962	Rard protein
IR208_RS07120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IR208_RS07125	COG0569	domain protein
IR208_RS07145	COG2807	transmembrane transport
IR208_RS07150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IR208_RS07160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR208_RS07170	COG1278	Cold shock
IR208_RS07175	COG0302	gtp cyclohydrolase
IR208_RS07180	COG3634	alkyl hydroperoxide reductase activity
IR208_RS07195	COG0577	efflux transmembrane transporter activity
IR208_RS07200	COG1136	(ABC) transporter
IR208_RS07205	COG0642	Histidine kinase
IR208_RS07210	COG0745	RESPONSE REGULATOR receiver
IR208_RS07235	COG0640	Transcriptional regulator
IR208_RS07240	COG2814	Major facilitator Superfamily
IR208_RS07245	COG5039	Polysaccharide pyruvyl transferase
IR208_RS07255	COG1113	amino acid transport
IR208_RS07270	COG0477	Major facilitator Superfamily
IR208_RS07280	COG1132	(ABC) transporter
IR208_RS07285	COG1132	(ABC) transporter
IR208_RS07295	COG1380	Effector of murein hydrolase LrgA
IR208_RS07300	COG1346	cytolysis
IR208_RS07305	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_RS07330	COG2309	aminopeptidase activity
IR208_RS07340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IR208_RS07360	COG0824	Thioesterase
IR208_RS07370	COG4841	protein insertion into membrane
IR208_RS07375	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IR208_RS07380	COG1832	CoA-binding protein
IR208_RS07385	COG0187	DNA topoisomerase II activity
IR208_RS07390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IR208_RS07405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IR208_RS07410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IR208_RS07410	COG0574	Belongs to the PEP-utilizing enzyme family
IR208_RS07435	COG2070	2-Nitropropane dioxygenase
IR208_RS07445	COG0681	Belongs to the peptidase S26 family
IR208_RS07450	COG0473	3-isopropylmalate dehydrogenase activity
IR208_RS07455	COG2226	methyltransferase
IR208_RS07480	COG0456	acetyltransferase
IR208_RS07485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IR208_RS07490	COG0456	acetyltransferase
IR208_RS07520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IR208_RS07525	COG0351	phosphomethylpyrimidine kinase
IR208_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS07535	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IR208_RS07540	COG0351	phosphomethylpyrimidine kinase
IR208_RS07550	COG2258	MOSC domain
IR208_RS07585	COG1309	transcriptional regulator
IR208_RS07590	COG2814	Major facilitator Superfamily
IR208_RS07595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR208_RS07600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR208_RS07610	COG1809	phosphosulfolactate synthase activity
IR208_RS07615	COG2045	Belongs to the ComB family
IR208_RS07620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IR208_RS07625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IR208_RS07635	COG0789	Transcriptional regulator
IR208_RS07640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IR208_RS07645	COG0697	spore germination
IR208_RS07650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IR208_RS07655	COG0022	dehydrogenase e1 component
IR208_RS07660	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR208_RS07665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR208_RS07670	COG3284	Transcriptional regulator
IR208_RS07675	COG1511	domain protein
IR208_RS07675	COG3264	Mechanosensitive ion channel
IR208_RS07690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR208_RS07695	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IR208_RS07710	COG0183	Belongs to the thiolase family
IR208_RS07715	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_RS07725	COG0561	phosphatase activity
IR208_RS07730	COG2322	membrane
IR208_RS07745	COG0039	L-malate dehydrogenase activity
IR208_RS07750	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS07755	COG2223	nitrite transmembrane transporter activity
IR208_RS07760	COG3773	Cell wall hydrolase
IR208_RS07765	COG0708	Exodeoxyribonuclease III
IR208_RS07775	COG0297	glycogen (starch) synthase activity
IR208_RS07780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IR208_RS07785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IR208_RS07790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IR208_RS07810	COG1247	-acetyltransferase
IR208_RS07815	COG0494	nUDIX hydrolase
IR208_RS07820	COG1914	H( )-stimulated, divalent metal cation uptake system
IR208_RS07825	COG0783	Belongs to the Dps family
IR208_RS07835	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IR208_RS07840	COG1131	(ABC) transporter
IR208_RS07865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IR208_RS07875	COG2030	dehydratase
IR208_RS07880	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS07895	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IR208_RS07900	COG0709	Synthesizes selenophosphate from selenide and ATP
IR208_RS07915	COG0701	Predicted permease
IR208_RS07920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IR208_RS07925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IR208_RS07935	COG1252	NADH dehydrogenase
IR208_RS07940	COG2404	hydrolase activity, acting on ester bonds
IR208_RS07950	COG4990	cell redox homeostasis
IR208_RS07955	COG0789	Transcriptional regulator
IR208_RS07980	COG0436	Aminotransferase
IR208_RS07985	COG0165	Argininosuccinate lyase
IR208_RS07990	COG0137	argininosuccinate synthase activity
IR208_RS07995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IR208_RS08000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IR208_RS08005	COG0505	Belongs to the CarA family
IR208_RS08010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IR208_RS08015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IR208_RS08020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IR208_RS08025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IR208_RS08040	COG3546	catalase activity
IR208_RS08060	COG1619	proteins homologs of microcin C7 resistance protein MccF
IR208_RS08065	COG2027	D-alanyl-D-alanine carboxypeptidase
IR208_RS08070	COG0204	Acyl-transferase
IR208_RS08080	COG4846	Membrane protein involved in cytochrome C biogenesis
IR208_RS08085	COG2201	protein-glutamate methylesterase activity
IR208_RS08090	COG0785	Cytochrome C biogenesis protein
IR208_RS08095	COG3763	UPF0154 protein
IR208_RS08110	COG4224	UPF0291 protein
IR208_RS08115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IR208_RS08125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IR208_RS08130	COG0174	glutamine synthetase
IR208_RS08135	COG0789	Transcriptional regulator
IR208_RS08140	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IR208_RS08155	COG2233	PERMEase
IR208_RS08165	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IR208_RS08170	COG0116	Belongs to the methyltransferase superfamily
IR208_RS08185	COG4474	Belongs to the UPF0398 family
IR208_RS08195	COG3359	exonuclease
IR208_RS08200	COG1205	dead DEAH box helicase
IR208_RS08200	COG1111	helicase
IR208_RS08205	COG0071	Belongs to the small heat shock protein (HSP20) family
IR208_RS08230	COG3331	DNA recombination
IR208_RS08235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IR208_RS08235	COG4499	WXG100 protein secretion system (Wss), protein YukC
IR208_RS08240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IR208_RS08245	COG3935	DnaD domain protein
IR208_RS08250	COG0017	Asparaginyl-tRNA synthetase
IR208_RS08265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IR208_RS08265	COG1199	ATP-dependent helicase activity
IR208_RS08270	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IR208_RS08275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IR208_RS08295	COG0438	transferase activity, transferring glycosyl groups
IR208_RS08300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IR208_RS08305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IR208_RS08310	COG1694	Mazg nucleotide pyrophosphohydrolase
IR208_RS08315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IR208_RS08325	COG2738	Putative neutral zinc metallopeptidase
IR208_RS08335	COG4347	Protein of unknown function (DUF1405)
IR208_RS08345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IR208_RS08360	COG5582	Belongs to the UPF0302 family
IR208_RS08365	COG0457	Tetratricopeptide repeat
IR208_RS08370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IR208_RS08375	COG0287	Prephenate dehydrogenase
IR208_RS08380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IR208_RS08385	COG4401	Chorismate mutase type I
IR208_RS08390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IR208_RS08395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IR208_RS08400	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IR208_RS08405	COG0105	UTP biosynthetic process
IR208_RS08410	COG0142	geranyltranstransferase activity
IR208_RS08415	COG2226	methyltransferase
IR208_RS08420	COG0142	geranyltranstransferase activity
IR208_RS08430	COG0776	regulation of translation
IR208_RS08435	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IR208_RS08455	COG1160	GTP binding
IR208_RS08470	COG0539	negative regulation of cytoplasmic translation
IR208_RS08475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IR208_RS08480	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
IR208_RS08485	COG2959	enzyme of heme biosynthesis
IR208_RS08490	COG3409	Peptidoglycan-binding domain 1 protein
IR208_RS08490	COG3773	Cell wall hydrolase
IR208_RS08495	COG2339	peptidase activity
IR208_RS08500	COG0492	ferredoxin-NADP+ reductase activity
IR208_RS08505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IR208_RS08515	COG1408	metallophosphoesterase
IR208_RS08530	COG3546	catalase activity
IR208_RS08545	COG1266	CAAX protease self-immunity
IR208_RS08550	COG0514	ATP-dependent DNA helicase (RecQ)
IR208_RS08560	COG1141	Ferredoxin
IR208_RS08565	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IR208_RS08570	COG1196	nuclear chromosome segregation
IR208_RS08570	COG0741	lytic transglycosylase activity
IR208_RS08570	COG0739	heme binding
IR208_RS08575	COG5002	protein histidine kinase activity
IR208_RS08580	COG0745	RESPONSE REGULATOR receiver
IR208_RS08585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IR208_RS08590	COG1333	cytochrome c biogenesis protein
IR208_RS08595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR208_RS08600	COG1187	pseudouridine synthase activity
IR208_RS08605	COG0700	Nucleoside recognition
IR208_RS08610	COG2715	membrane protein required for spore maturation
IR208_RS08615	COG1686	Belongs to the peptidase S11 family
IR208_RS08620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IR208_RS08645	COG0697	spore germination
IR208_RS08665	COG1191	sigma factor activity
IR208_RS08680	COG1686	Belongs to the peptidase S11 family
IR208_RS08685	COG4974	Belongs to the 'phage' integrase family
IR208_RS08695	COG0735	belongs to the Fur family
IR208_RS08700	COG1300	Membrane
IR208_RS08705	COG1379	DNA repair
IR208_RS08720	COG0667	Aldo Keto reductase
IR208_RS08730	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
IR208_RS08735	COG3853	Toxic anion resistance protein (TelA)
IR208_RS08740	COG1073	alpha beta
IR208_RS08745	COG1388	LysM domain
IR208_RS08745	COG3858	chitin binding
IR208_RS08755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IR208_RS08760	COG0300	oxidoreductase activity
IR208_RS08765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IR208_RS08775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IR208_RS08780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IR208_RS08790	COG2195	Cleaves the N-terminal amino acid of tripeptides
IR208_RS08805	COG1376	ErfK ybiS ycfS ynhG family protein
IR208_RS08815	COG1105	Belongs to the carbohydrate kinase PfkB family
IR208_RS08820	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR208_RS08825	COG0022	dehydrogenase e1 component
IR208_RS08830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IR208_RS08835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR208_RS08855	COG0584	glycerophosphoryl diester phosphodiesterase
IR208_RS08860	COG0745	RESPONSE REGULATOR receiver
IR208_RS08865	COG0750	zinc metalloprotease
IR208_RS08870	COG0497	DNA recombination
IR208_RS08880	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IR208_RS08885	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IR208_RS08900	COG1570	exodeoxyribonuclease VII activity
IR208_RS08915	COG1302	Protein conserved in bacteria
IR208_RS08920	COG0439	Biotin carboxylase
IR208_RS08925	COG0511	ligase activity, forming carbon-carbon bonds
IR208_RS08965	COG3854	ATPases associated with a variety of cellular activities
IR208_RS08970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IR208_RS08975	COG0006	proline dipeptidase activity
IR208_RS08980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IR208_RS08990	COG3872	metal-dependent enzyme
IR208_RS09000	COG1752	Esterase of the alpha-beta hydrolase superfamily
IR208_RS09010	COG3327	negative regulation of DNA-templated transcription, initiation
IR208_RS09015	COG0183	Belongs to the thiolase family
IR208_RS09020	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR208_RS09025	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS09030	COG1024	Enoyl-CoA hydratase
IR208_RS09035	COG0492	ferredoxin-NADP+ reductase activity
IR208_RS09040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR208_RS09045	COG0095	Lipoate-protein ligase
IR208_RS09050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IR208_RS09055	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IR208_RS09065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IR208_RS09070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IR208_RS09085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IR208_RS09110	COG4537	Required for transformation and DNA binding
IR208_RS09115	COG1459	type II secretion system
IR208_RS09120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IR208_RS09135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR208_RS09145	COG1940	carbohydrate kinase activity
IR208_RS09150	COG4483	Protein conserved in bacteria
IR208_RS09155	COG0457	Tetratricopeptide repeat
IR208_RS09155	COG0705	Rhomboid family
IR208_RS09165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IR208_RS09175	COG0768	penicillin binding
IR208_RS09180	COG0477	Major facilitator Superfamily
IR208_RS09185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IR208_RS09195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IR208_RS09200	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
IR208_RS09205	COG0735	belongs to the Fur family
IR208_RS09210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IR208_RS09215	COG1121	(ABC) transporter
IR208_RS09225	COG0791	NLP P60 protein
IR208_RS09225	COG3883	PFAM NLP P60 protein
IR208_RS09230	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IR208_RS09235	COG0513	Belongs to the DEAD box helicase family
IR208_RS09245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IR208_RS09250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IR208_RS09255	COG2384	SAM-dependent methyltransferase
IR208_RS09260	COG2010	Cytochrome c
IR208_RS09270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IR208_RS09275	COG0358	DNA primase activity
IR208_RS09285	COG0517	IMP dehydrogenase activity
IR208_RS09290	COG1381	Involved in DNA repair and RecF pathway recombination
IR208_RS09305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IR208_RS09310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IR208_RS09315	COG1480	7TM receptor with intracellular HD hydrolase
IR208_RS09320	COG1702	phosphate starvation-inducible protein PhoH
IR208_RS09335	COG1610	YqeY-like protein
IR208_RS09350	COG1283	sodium-dependent phosphate transmembrane transporter activity
IR208_RS09355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IR208_RS09360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IR208_RS09365	COG2264	protein methyltransferase activity
IR208_RS09375	COG0443	Heat shock 70 kDa protein
IR208_RS09380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IR208_RS09390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IR208_RS09395	COG0481	GTPase activity
IR208_RS09400	COG0860	N-Acetylmuramoyl-L-alanine amidase
IR208_RS09405	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IR208_RS09410	COG0268	Binds directly to 16S ribosomal RNA
IR208_RS09415	COG1466	dna polymerase III delta subunit
IR208_RS09425	COG2333	competence protein COMEC
IR208_RS09425	COG0658	competence protein
IR208_RS09430	COG2131	deaminase
IR208_RS09435	COG1555	photosystem II stabilization
IR208_RS09435	COG1596	polysaccharide export
IR208_RS09440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IR208_RS09445	COG2226	methyltransferase
IR208_RS09450	COG0799	negative regulation of ribosome biogenesis
IR208_RS09455	COG1713	HD superfamily hydrolase involved in NAD metabolism
IR208_RS09460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IR208_RS09465	COG1534	Rna-binding protein
IR208_RS09475	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IR208_RS09480	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IR208_RS09485	COG0247	lactate metabolic process
IR208_RS09490	COG0277	FAD linked oxidase domain protein
IR208_RS09495	COG3835	regulator
IR208_RS09500	COG2132	Multicopper oxidase
IR208_RS09505	COG0071	Belongs to the small heat shock protein (HSP20) family
IR208_RS09510	COG2210	Belongs to the sulfur carrier protein TusA family
IR208_RS09525	COG0446	pyridine nucleotide-disulphide oxidoreductase
IR208_RS09540	COG0071	Belongs to the small heat shock protein (HSP20) family
IR208_RS09550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR208_RS09560	COG1704	LemA family
IR208_RS09570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IR208_RS09590	COG1183	phosphatidylcholine synthase activity
IR208_RS09610	COG0450	alkyl hydroperoxide reductase
IR208_RS09640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IR208_RS09645	COG0572	uridine kinase
IR208_RS09650	COG4122	O-methyltransferase activity
IR208_RS09655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IR208_RS09660	COG3906	Belongs to the UPF0473 family
IR208_RS09665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IR208_RS09670	COG4472	Bacterial protein of unknown function (DUF965)
IR208_RS09675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IR208_RS09680	COG0628	permease
IR208_RS09710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IR208_RS09720	COG0482	sulfurtransferase activity
IR208_RS09725	COG1104	cysteine desulfurase activity
IR208_RS09730	COG1959	2 iron, 2 sulfur cluster binding
IR208_RS09750	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS09755	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IR208_RS09760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IR208_RS09765	COG0385	Bile acid
IR208_RS09775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IR208_RS09780	COG0124	histidyl-tRNA synthetase
IR208_RS09790	COG4991	sh3 domain protein
IR208_RS09790	COG0860	N-Acetylmuramoyl-L-alanine amidase
IR208_RS09790	COG3103	Sh3 type 3 domain protein
IR208_RS09795	COG2814	Major facilitator Superfamily
IR208_RS09800	COG1566	PFAM secretion protein HlyD family protein
IR208_RS09805	COG1846	Transcriptional regulator
IR208_RS09810	COG1490	D-aminoacyl-tRNA deacylase activity
IR208_RS09815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IR208_RS09820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IR208_RS09825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IR208_RS09825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IR208_RS09830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IR208_RS09830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IR208_RS09840	COG2244	polysaccharide biosynthetic process
IR208_RS09845	COG2323	membrane
IR208_RS09855	COG1862	Preprotein translocase
IR208_RS09860	COG0343	queuine tRNA-ribosyltransferase activity
IR208_RS09865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IR208_RS09880	COG0632	four-way junction helicase activity
IR208_RS09885	COG0217	transcriptional regulatory protein
IR208_RS09895	COG1388	LysM domain
IR208_RS09900	COG1827	regulation of RNA biosynthetic process
IR208_RS09905	COG0077	Prephenate dehydratase
IR208_RS09910	COG4492	Belongs to the UPF0735 family
IR208_RS09915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IR208_RS09920	COG3290	protein histidine kinase activity
IR208_RS09925	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IR208_RS09930	COG2868	ribosomal protein
IR208_RS09935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IR208_RS09940	COG1530	ribonuclease E activity
IR208_RS09945	COG1994	Peptidase M50
IR208_RS09955	COG2894	cell division
IR208_RS09960	COG0850	regulation of cytokinetic process
IR208_RS09970	COG1792	Involved in formation and maintenance of cell shape
IR208_RS09975	COG1077	Cell shape determining protein MreB Mrl
IR208_RS09980	COG2003	Belongs to the UPF0758 family
IR208_RS09990	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IR208_RS10020	COG1459	type II secretion system
IR208_RS10030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IR208_RS10065	COG0285	dihydrofolate synthase activity
IR208_RS10070	COG0525	valine-tRNA ligase activity
IR208_RS10080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IR208_RS10085	COG1388	LysM domain
IR208_RS10085	COG1388	LysM domain
IR208_RS10090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IR208_RS10095	COG0113	porphobilinogen synthase activity
IR208_RS10105	COG0181	hydroxymethylbilane synthase activity
IR208_RS10110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IR208_RS10125	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IR208_RS10130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IR208_RS10135	COG1067	ATP-dependent peptidase activity
IR208_RS10135	COG0470	DNA polymerase III
IR208_RS10145	COG0544	peptidyl-prolyl cis-trans isomerase activity
IR208_RS10150	COG0457	Tetratricopeptide repeat
IR208_RS10150	COG1477	protein flavinylation
IR208_RS10175	COG0622	Phosphoesterase
IR208_RS10180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IR208_RS10185	COG5401	PFAM Sporulation and spore germination
IR208_RS10195	COG5577	PFAM Coat F domain
IR208_RS10200	COG1063	alcohol dehydrogenase
IR208_RS10205	COG5577	PFAM Coat F domain
IR208_RS10220	COG1846	Transcriptional regulator
IR208_RS10245	COG2197	response regulator
IR208_RS10250	COG0824	Thioesterase
IR208_RS10255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IR208_RS10260	COG1053	succinate dehydrogenase
IR208_RS10265	COG2009	succinate dehydrogenase
IR208_RS10270	COG1719	4-vinyl reductase, 4VR
IR208_RS10280	COG0322	excinuclease ABC activity
IR208_RS10285	COG3118	belongs to the thioredoxin family
IR208_RS10290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IR208_RS10295	COG2086	electron transfer activity
IR208_RS10300	COG1024	Enoyl-CoA hydratase
IR208_RS10305	COG1309	transcriptional regulator
IR208_RS10310	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_RS10315	COG1193	negative regulation of DNA recombination
IR208_RS10320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IR208_RS10320	COG1796	DNA polymerase
IR208_RS10325	COG1286	toxin biosynthetic process
IR208_RS10330	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IR208_RS10340	COG0072	phenylalanine-tRNA ligase activity
IR208_RS10340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR208_RS10345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IR208_RS10350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IR208_RS10385	COG2329	Antibiotic biosynthesis monooxygenase
IR208_RS10395	COG1695	Transcriptional regulator
IR208_RS10415	COG0431	NADPH-dependent FMN reductase
IR208_RS10450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IR208_RS10460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IR208_RS10475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IR208_RS10485	COG1484	DNA-dependent DNA replication
IR208_RS10490	COG3611	Membrane attachment protein
IR208_RS10495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IR208_RS10500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IR208_RS10505	COG0237	dephospho-CoA kinase activity
IR208_RS10510	COG1971	Probably functions as a manganese efflux pump
IR208_RS10515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IR208_RS10520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR208_RS10520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR208_RS10525	COG0039	L-malate dehydrogenase activity
IR208_RS10530	COG0538	isocitrate dehydrogenase activity
IR208_RS10535	COG0372	Belongs to the citrate synthase family
IR208_RS10540	COG2707	UPF0756 membrane protein
IR208_RS10545	COG0628	permease
IR208_RS10555	COG0205	6-phosphofructokinase activity
IR208_RS10560	COG0825	malonyl-CoA metabolic process
IR208_RS10565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IR208_RS10570	COG0281	malic enzyme
IR208_RS10575	COG0587	DNA-directed DNA polymerase activity
IR208_RS10590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IR208_RS10600	COG4109	DRTGG domain
IR208_RS10605	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IR208_RS10610	COG0006	proline dipeptidase activity
IR208_RS10620	COG0589	response to stress
IR208_RS10630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IR208_RS10635	COG0827	DNA restriction-modification system
IR208_RS10640	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IR208_RS10645	COG3874	Sporulation protein YtfJ
IR208_RS10655	COG1714	RDD family
IR208_RS10660	COG0616	signal peptide processing
IR208_RS10665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR208_RS10675	COG0301	tRNA thio-modification
IR208_RS10680	COG1104	cysteine desulfurase activity
IR208_RS10685	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
IR208_RS10690	COG1309	transcriptional regulator
IR208_RS10695	COG1956	GAF domain-containing protein
IR208_RS10700	COG2203	Gaf domain
IR208_RS10700	COG2199	diguanylate cyclase activity
IR208_RS10705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IR208_RS10720	COG0506	proline dehydrogenase activity
IR208_RS10725	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS10730	COG3290	protein histidine kinase activity
IR208_RS10730	COG3829	transcription factor binding
IR208_RS10740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IR208_RS10755	COG3383	formate dehydrogenase (NAD+) activity
IR208_RS10760	COG2427	Protein of unknown function (DUF1641)
IR208_RS10765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IR208_RS10770	COG0315	cyclic pyranopterin monophosphate synthase activity
IR208_RS10775	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IR208_RS10780	COG0314	molybdopterin synthase activity
IR208_RS10785	COG1763	Mo-molybdopterin cofactor biosynthetic process
IR208_RS10790	COG0303	'Molybdopterin
IR208_RS10805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IR208_RS10815	COG4149	molybdate abc transporter
IR208_RS10825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR208_RS10830	COG0454	-acetyltransferase
IR208_RS10835	COG0517	IMP dehydrogenase activity
IR208_RS10840	COG0123	including yeast histone deacetylase and acetoin utilization protein
IR208_RS10850	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IR208_RS10850	COG1605	Chorismate mutase
IR208_RS10855	COG4980	gas vesicle protein
IR208_RS10865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IR208_RS10870	COG1674	ftsk spoiiie
IR208_RS10880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR208_RS10885	COG4848	Belongs to the UPF0354 family
IR208_RS10890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR208_RS10895	COG2208	phosphoserine phosphatase activity
IR208_RS10900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IR208_RS10905	COG5002	protein histidine kinase activity
IR208_RS10905	COG0784	Response regulator, receiver
IR208_RS10930	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IR208_RS10935	COG1363	Peptidase, m42
IR208_RS10940	COG5584	Small secreted protein
IR208_RS10945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR208_RS10950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IR208_RS10960	COG0510	thiamine kinase activity
IR208_RS10985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IR208_RS10990	COG1349	DNA-binding transcription factor activity
IR208_RS10995	COG2244	polysaccharide biosynthetic process
IR208_RS11015	COG0495	leucyl-tRNA aminoacylation
IR208_RS11020	COG2814	Major facilitator Superfamily
IR208_RS11030	COG0275	rRNA processing
IR208_RS11040	COG2267	carboxylic ester hydrolase activity
IR208_RS11045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IR208_RS11050	COG0367	asparagine synthase
IR208_RS11055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IR208_RS11060	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IR208_RS11070	COG1506	peptidase
IR208_RS11075	COG0655	NAD(P)H dehydrogenase (quinone) activity
IR208_RS11080	COG1070	Carbohydrate kinase
IR208_RS11085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR208_RS11090	COG1116	anion transmembrane transporter activity
IR208_RS11095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR208_RS11110	COG0783	Belongs to the Dps family
IR208_RS11115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IR208_RS11125	COG0803	Belongs to the bacterial solute-binding protein 9 family
IR208_RS11135	COG4948	Mandelate Racemase Muconate Lactonizing
IR208_RS11140	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_RS11145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IR208_RS11150	COG0596	Alpha beta hydrolase
IR208_RS11155	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IR208_RS11160	COG1169	isochorismate synthase
IR208_RS11165	COG1575	Belongs to the MenA family. Type 1 subfamily
IR208_RS11310	COG1285	pathogenesis
IR208_RS11325	COG2217	Heavy metal translocating P-type atpase
IR208_RS11330	COG2608	mercury ion transmembrane transporter activity
IR208_RS11345	COG1522	sequence-specific DNA binding
IR208_RS11365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IR208_RS11400	COG5002	protein histidine kinase activity
IR208_RS11405	COG0745	RESPONSE REGULATOR receiver
IR208_RS11410	COG1388	LysM domain
IR208_RS11415	COG4221	oxidoreductase activity
IR208_RS11425	COG0726	polysaccharide deacetylase
IR208_RS11450	COG0038	chloride channel
IR208_RS11460	COG0425	Belongs to the sulfur carrier protein TusA family
IR208_RS11460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IR208_RS11465	COG1937	Protein conserved in bacteria
IR208_RS11470	COG1525	nuclease
IR208_RS11475	COG2190	(PTS) system
IR208_RS11490	COG3534	alpha-L-arabinofuranosidase
IR208_RS11495	COG2160	L-arabinose isomerase activity
IR208_RS11515	COG0395	ABC-type sugar transport system, permease component
IR208_RS11520	COG1175	transmembrane transport
IR208_RS11525	COG1653	transport
IR208_RS11530	COG1609	Transcriptional regulator
IR208_RS11535	COG3940	Belongs to the glycosyl hydrolase 43 family
IR208_RS11540	COG2223	nitrite transmembrane transporter activity
IR208_RS11545	COG3507	Belongs to the glycosyl hydrolase 43 family
IR208_RS11550	COG3328	transposase activity
IR208_RS11560	COG0840	transmembrane signaling receptor activity
IR208_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS11580	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
IR208_RS11595	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS11615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IR208_RS11625	COG2155	Conserved Protein
IR208_RS11635	COG1098	S1 RNA binding domain
IR208_RS11645	COG1902	pentaerythritol trinitrate reductase activity
IR208_RS11650	COG0656	L-ascorbic acid biosynthetic process
IR208_RS11670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IR208_RS11680	COG2814	Major facilitator Superfamily
IR208_RS11685	COG2050	protein possibly involved in aromatic compounds catabolism
IR208_RS11695	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IR208_RS11705	COG0697	spore germination
IR208_RS11715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IR208_RS11720	COG3584	3D domain protein
IR208_RS11730	COG1252	NADH dehydrogenase
IR208_RS11735	COG0492	ferredoxin-NADP+ reductase activity
IR208_RS11760	COG0316	Belongs to the HesB IscA family
IR208_RS11765	COG4837	Protein of unknown function (DUF1462)
IR208_RS11770	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IR208_RS11775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IR208_RS11780	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IR208_RS11785	COG0647	UMP catabolic process
IR208_RS11790	COG2445	Protein of unknown function DUF86
IR208_RS11795	COG4470	Protein conserved in bacteria
IR208_RS11800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IR208_RS11805	COG0739	heme binding
IR208_RS11815	COG3377	Domain of unknown function (DUF1805)
IR208_RS11820	COG0737	Belongs to the 5'-nucleotidase family
IR208_RS11825	COG0719	Fe-S assembly protein
IR208_RS11830	COG0822	iron-sulfur transferase activity
IR208_RS11835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IR208_RS11840	COG0719	Fe-S assembly protein
IR208_RS11845	COG0396	ATPase activity
IR208_RS11855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR208_RS11860	COG0509	glycine decarboxylation via glycine cleavage system
IR208_RS11865	COG1393	Belongs to the ArsC family
IR208_RS11870	COG1960	acyl-CoA dehydrogenase activity
IR208_RS11875	COG0183	Belongs to the thiolase family
IR208_RS11880	COG1024	Enoyl-CoA hydratase
IR208_RS11880	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR208_RS11895	COG5577	PFAM Coat F domain
IR208_RS11900	COG0772	Belongs to the SEDS family
IR208_RS11905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR208_RS11920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IR208_RS11935	COG0753	catalase activity
IR208_RS11940	COG0671	phosphoesterase, PA-phosphatase related
IR208_RS11950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IR208_RS11965	COG1595	DNA-templated transcription, initiation
IR208_RS11970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IR208_RS11985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IR208_RS11995	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IR208_RS12000	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS12005	COG2211	Major facilitator Superfamily
IR208_RS12010	COG1904	glucuronate isomerase
IR208_RS12015	COG2721	sulfolactate sulfo-lyase activity
IR208_RS12020	COG0246	Mannitol dehydrogenase
IR208_RS12030	COG0800	Aldolase
IR208_RS12035	COG1414	Transcriptional regulator
IR208_RS12050	COG0488	(ABC) transporter
IR208_RS12125	COG0557	exoribonuclease II activity
IR208_RS12135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IR208_RS12140	COG0148	phosphopyruvate hydratase activity
IR208_RS12145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IR208_RS12155	COG0126	phosphoglycerate kinase activity
IR208_RS12175	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IR208_RS12195	COG3383	formate dehydrogenase (NAD+) activity
IR208_RS12230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IR208_RS12245	COG4608	Belongs to the ABC transporter superfamily
IR208_RS12250	COG0791	NLP P60 protein
IR208_RS12255	COG4166	transmembrane transport
IR208_RS12260	COG0444	Belongs to the ABC transporter superfamily
IR208_RS12265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR208_RS12270	COG0601	transmembrane transport
IR208_RS12275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IR208_RS12285	COG0598	Magnesium transport protein CorA
IR208_RS12295	COG2719	SpoVR family
IR208_RS12300	COG3594	Acyltransferase
IR208_RS12325	COG1392	Phosphate transport regulator
IR208_RS12330	COG0306	phosphate transporter
IR208_RS12345	COG2718	Belongs to the UPF0229 family
IR208_RS12350	COG2766	serine protein kinase
IR208_RS12360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IR208_RS12375	COG2095	MarC family integral membrane protein
IR208_RS12385	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IR208_RS12390	COG0596	Alpha beta hydrolase
IR208_RS12395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR208_RS12400	COG0765	amino acid transport
IR208_RS12405	COG1126	abc transporter atp-binding protein
IR208_RS12410	COG2116	formate transmembrane transporter activity
IR208_RS12430	COG1882	Formate acetyltransferase
IR208_RS12435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IR208_RS12440	COG0431	NADPH-dependent FMN reductase
IR208_RS12455	COG1131	(ABC) transporter
IR208_RS12480	COG0745	RESPONSE REGULATOR receiver
IR208_RS12485	COG5002	protein histidine kinase activity
IR208_RS12485	COG3850	Histidine kinase
IR208_RS12495	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IR208_RS12535	COG4977	sequence-specific DNA binding
IR208_RS12535	COG1917	Cupin 2, conserved barrel domain protein
IR208_RS12540	COG1874	Beta-galactosidase
IR208_RS12560	COG2271	Major facilitator Superfamily
IR208_RS12585	COG0697	spore germination
IR208_RS12600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IR208_RS12715	COG3527	Alpha-acetolactate decarboxylase
IR208_RS12720	COG0028	Belongs to the TPP enzyme family
IR208_RS12725	COG0583	DNA-binding transcription factor activity
IR208_RS12730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IR208_RS12735	COG0549	Belongs to the carbamate kinase family
IR208_RS12745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IR208_RS12755	COG0735	belongs to the Fur family
IR208_RS12770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IR208_RS12775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR208_RS12780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR208_RS12785	COG1116	anion transmembrane transporter activity
IR208_RS12790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IR208_RS12795	COG2814	Major facilitator Superfamily
IR208_RS12815	COG1737	Transcriptional regulator
IR208_RS12820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_RS12820	COG1263	PTS System
IR208_RS12825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IR208_RS12835	COG1132	(ABC) transporter
IR208_RS12840	COG3557	Belongs to the UPF0374 family
IR208_RS12855	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS12860	COG0583	DNA-binding transcription factor activity
IR208_RS12865	COG0069	glutamate synthase activity
IR208_RS12865	COG0070	glutamate synthase
IR208_RS12865	COG0067	glutamate synthase
IR208_RS12870	COG0493	'glutamate synthase
IR208_RS12885	COG1194	a g-specific adenine glycosylase
IR208_RS12890	COG1988	membrane-bound metal-dependent
IR208_RS12920	COG0159	tryptophan synthase activity
IR208_RS12930	COG0133	tryptophan synthase activity
IR208_RS12935	COG0134	indole-3-glycerol-phosphate synthase activity
IR208_RS12940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IR208_RS12945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IR208_RS12945	COG0512	Glutamine amidotransferase of anthranilate synthase
IR208_RS12955	COG0577	efflux transmembrane transporter activity
IR208_RS12960	COG0577	efflux transmembrane transporter activity
IR208_RS12960	COG1136	(ABC) transporter
IR208_RS12965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR208_RS12980	COG1131	(ABC) transporter
IR208_RS13015	COG2197	response regulator
IR208_RS13020	COG4585	Histidine kinase
IR208_RS13035	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS13035	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS13045	COG0058	SHG alpha-glucan phosphorylase activity
IR208_RS13050	COG0840	transmembrane signaling receptor activity
IR208_RS13055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IR208_RS13060	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IR208_RS13065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IR208_RS13080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IR208_RS13085	COG0066	3-isopropylmalate dehydratase activity
IR208_RS13090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IR208_RS13100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IR208_RS13105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IR208_RS13110	COG0440	acetolactate synthase activity
IR208_RS13115	COG0028	Belongs to the TPP enzyme family
IR208_RS13120	COG0129	dihydroxy-acid dehydratase activity
IR208_RS13125	COG1114	Component of the transport system for branched-chain amino acids
IR208_RS13130	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_RS13160	COG0670	Belongs to the BI1 family
IR208_RS13165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IR208_RS13170	COG2223	nitrite transmembrane transporter activity
IR208_RS13175	COG3279	Response regulator of the LytR AlgR family
IR208_RS13180	COG3275	phosphorelay sensor kinase activity
IR208_RS13185	COG0252	asparaginase activity
IR208_RS13190	COG2132	Multicopper oxidase
IR208_RS13195	COG1309	transcriptional regulator
IR208_RS13200	COG1511	domain protein
IR208_RS13235	COG0840	transmembrane signaling receptor activity
IR208_RS13235	COG5278	phosphoserine phosphatase activity
IR208_RS13240	COG3739	integral membrane protein
IR208_RS13245	COG3655	Transcriptional regulator
IR208_RS13260	COG1823	symporter activity
IR208_RS13265	COG2839	Protein conserved in bacteria
IR208_RS13285	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
IR208_RS13310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IR208_RS13315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IR208_RS13320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IR208_RS13325	COG0840	transmembrane signaling receptor activity
IR208_RS13340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IR208_RS13345	COG1132	(ABC) transporter
IR208_RS13350	COG1846	Transcriptional regulator
IR208_RS13375	COG0798	PFAM Bile acid sodium symporter
IR208_RS13415	COG0024	Methionine aminopeptidase
IR208_RS13435	COG0464	growth
IR208_RS13575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IR208_RS13580	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IR208_RS13600	COG0387	Pfam Sodium calcium exchanger
IR208_RS13605	COG0477	Major facilitator Superfamily
IR208_RS13610	COG1295	ribonuclease BN
IR208_RS13615	COG4840	Belongs to the UPF0435 family
IR208_RS13620	COG0024	Methionine aminopeptidase
IR208_RS13625	COG0693	protein deglycase activity
IR208_RS13630	COG1360	Flagellar Motor Protein
IR208_RS13635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IR208_RS13650	COG3189	MarR family transcriptional regulator
IR208_RS13660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IR208_RS13665	COG1607	acyl-coa hydrolase
IR208_RS13670	COG1077	Cell shape determining protein MreB Mrl
IR208_RS13675	COG2268	Band 7 protein
IR208_RS13680	COG1585	Membrane protein implicated in regulation of membrane protease activity
IR208_RS13685	COG0626	cystathionine gamma-synthase activity
IR208_RS13690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IR208_RS13695	COG1854	S-ribosylhomocysteine lyase activity
IR208_RS13705	COG0288	reversible hydration of carbon dioxide
IR208_RS13715	COG0860	N-Acetylmuramoyl-L-alanine amidase
IR208_RS13725	COG2197	response regulator
IR208_RS13745	COG4086	secreted protein
IR208_RS13750	COG0737	Belongs to the 5'-nucleotidase family
IR208_RS13770	COG3620	sequence-specific DNA binding
IR208_RS13775	COG3328	transposase activity
IR208_RS13795	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IR208_RS13800	COG1518	maintenance of DNA repeat elements
IR208_RS13855	COG1304	FMN binding
IR208_RS13860	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IR208_RS13865	COG0166	Belongs to the GPI family
IR208_RS13870	COG0025	NhaP-type Na H and K H
IR208_RS13885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_RS13885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IR208_RS13885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IR208_RS13890	COG1349	DNA-binding transcription factor activity
IR208_RS13900	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IR208_RS13910	COG0561	phosphatase activity
IR208_RS13925	COG2814	Major facilitator Superfamily
IR208_RS13930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IR208_RS13950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IR208_RS13955	COG0667	Aldo Keto reductase
IR208_RS13960	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IR208_RS13965	COG1461	Dihydroxyacetone kinase
IR208_RS13970	COG2376	Dihydroxyacetone kinase
IR208_RS13980	COG0778	Nitroreductase
IR208_RS13985	COG1113	amino acid transport
IR208_RS13990	COG0730	response to heat
IR208_RS13995	COG2233	PERMEase
IR208_RS14010	COG2233	PERMEase
IR208_RS14020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IR208_RS14035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IR208_RS14040	COG1024	Enoyl-CoA hydratase
IR208_RS14045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IR208_RS14050	COG0511	ligase activity, forming carbon-carbon bonds
IR208_RS14055	COG0439	Biotin carboxylase
IR208_RS14060	COG1960	acyl-CoA dehydrogenase activity
IR208_RS14065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR208_RS14080	COG1349	DNA-binding transcription factor activity
IR208_RS14090	COG2376	Dihydroxyacetone kinase
IR208_RS14100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IR208_RS14110	COG2271	Major facilitator Superfamily
IR208_RS14115	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR208_RS14125	COG0698	ribose 5-phosphate isomerase
IR208_RS14130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IR208_RS14135	COG1494	fructose-1,6-bisphosphatase
IR208_RS14140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IR208_RS14145	COG3829	transcription factor binding
IR208_RS14150	COG0833	amino acid
IR208_RS14185	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IR208_RS14190	COG1140	nitrate reductase beta subunit
IR208_RS14200	COG2181	nitrate reductase activity
IR208_RS14205	COG2223	nitrite transmembrane transporter activity
IR208_RS14210	COG3588	fructose-bisphosphate aldolase
IR208_RS14215	COG1657	PFAM Prenyltransferase squalene oxidase
IR208_RS14220	COG1349	DNA-binding transcription factor activity
IR208_RS14255	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IR208_RS14280	COG1280	lysine exporter protein (LysE YggA)
IR208_RS14285	COG0386	Belongs to the glutathione peroxidase family
IR208_RS14290	COG2190	(PTS) system
IR208_RS14310	COG0582	viral genome integration into host DNA
IR208_RS14340	COG1328	CTP reductase activity
IR208_RS14350	COG1063	alcohol dehydrogenase
IR208_RS14355	COG1929	Belongs to the glycerate kinase type-1 family
IR208_RS14375	COG1879	ABC-type sugar transport system periplasmic component
IR208_RS14380	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR208_RS14385	COG1129	ABC transporter
IR208_RS14390	COG1869	D-ribose catabolic process
IR208_RS14395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR208_RS14400	COG1609	Transcriptional regulator
IR208_RS14440	COG4549	nuclear export factor GLE1
IR208_RS14445	COG2372	response to copper ion
IR208_RS14445	COG1276	copper resistance
IR208_RS14455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IR208_RS14460	COG1609	Transcriptional regulator
IR208_RS14475	COG5002	protein histidine kinase activity
IR208_RS14480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR208_RS14495	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IR208_RS14505	COG2204	response regulator
IR208_RS14510	COG1606	tRNA processing
IR208_RS14515	COG2610	gluconate transmembrane transporter activity
IR208_RS14525	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IR208_RS14530	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IR208_RS14535	COG1691	(AIR) carboxylase
IR208_RS14555	COG1278	Cold shock
IR208_RS14560	COG0697	spore germination
IR208_RS14565	COG1472	Belongs to the glycosyl hydrolase 3 family
IR208_RS14575	COG3876	Protein conserved in bacteria
IR208_RS14590	COG1132	(ABC) transporter
IR208_RS14595	COG1132	(ABC) transporter
IR208_RS14605	COG1349	DNA-binding transcription factor activity
IR208_RS14610	COG1082	Xylose isomerase domain protein TIM barrel
IR208_RS14615	COG1082	Xylose isomerase domain protein TIM barrel
IR208_RS14620	COG0673	inositol 2-dehydrogenase activity
IR208_RS14625	COG2814	Major facilitator Superfamily
IR208_RS14630	COG1082	Xylose isomerase domain protein TIM barrel
IR208_RS14635	COG0673	inositol 2-dehydrogenase activity
IR208_RS14640	COG1082	Xylose isomerase domain protein TIM barrel
IR208_RS14645	COG0673	inositol 2-dehydrogenase activity
IR208_RS14650	COG1082	Xylose isomerase domain protein TIM barrel
IR208_RS14655	COG2814	Major facilitator Superfamily
IR208_RS14660	COG2814	Major facilitator Superfamily
IR208_RS14665	COG0191	fructose-bisphosphate aldolase activity
IR208_RS14670	COG3962	Belongs to the TPP enzyme family
IR208_RS14675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR208_RS14680	COG3718	enzyme involved in inositol metabolism
IR208_RS14685	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS14690	COG0791	NLP P60 protein
IR208_RS14690	COG1388	LysM domain
IR208_RS14710	COG2272	Belongs to the type-B carboxylesterase lipase family
IR208_RS14715	COG0154	amidase activity
IR208_RS14720	COG2814	Major facilitator Superfamily
IR208_RS14725	COG1012	belongs to the aldehyde dehydrogenase family
IR208_RS14755	COG3153	acetyltransferase
IR208_RS14755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IR208_RS14760	COG5583	Uncharacterized small protein (DUF2292)
IR208_RS14765	COG0431	NADPH-dependent FMN reductase
IR208_RS14770	COG1116	anion transmembrane transporter activity
IR208_RS14775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR208_RS14780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IR208_RS14785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR208_RS14815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IR208_RS14830	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IR208_RS14840	COG2390	Transcriptional regulator
IR208_RS14850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IR208_RS14860	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IR208_RS14875	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IR208_RS14880	COG1984	allophanate hydrolase subunit 2
IR208_RS14885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IR208_RS14890	COG2814	Major facilitator Superfamily
IR208_RS14895	COG1764	response to oxidative stress
IR208_RS14900	COG1126	abc transporter atp-binding protein
IR208_RS14905	COG0765	amino acid transport
IR208_RS14910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR208_RS14920	COG0326	Molecular chaperone. Has ATPase activity
IR208_RS14940	COG0800	Aldolase
IR208_RS14955	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_RS14960	COG3716	PTS system mannose fructose sorbose family IID component
IR208_RS14970	COG0371	Dehydrogenase
IR208_RS14980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IR208_RS14985	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IR208_RS14990	COG1737	Transcriptional regulator
IR208_RS14995	COG0561	phosphatase activity
IR208_RS15010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR208_RS15025	COG1064	alcohol dehydrogenase
IR208_RS15060	COG2814	Major facilitator Superfamily
IR208_RS15065	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS15110	COG3716	PTS system mannose fructose sorbose family IID component
IR208_RS15165	COG3829	transcription factor binding
IR208_RS15210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IR208_RS15215	COG1597	lipid kinase activity
IR208_RS15235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IR208_RS15240	COG0154	amidase activity
IR208_RS15245	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IR208_RS15250	COG2224	Isocitrate lyase
IR208_RS15255	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IR208_RS15260	COG4851	CamS sex pheromone cAM373 precursor
IR208_RS15270	COG0210	DNA helicase
IR208_RS15275	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IR208_RS15280	COG4496	protein, YerC YecD
IR208_RS15285	COG1470	cell adhesion involved in biofilm formation
IR208_RS15300	COG0151	Belongs to the GarS family
IR208_RS15305	COG0138	bifunctional purine biosynthesis protein purh
IR208_RS15310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IR208_RS15315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IR208_RS15320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IR208_RS15325	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IR208_RS15330	COG0047	phosphoribosylformylglycinamidine synthase activity
IR208_RS15335	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IR208_RS15345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IR208_RS15350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IR208_RS15355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IR208_RS15365	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
IR208_RS15370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IR208_RS15390	COG1301	dicarboxylic acid transport
IR208_RS15400	COG3711	transcriptional antiterminator
IR208_RS15405	COG2252	PERMEase
IR208_RS15415	COG1132	(ABC) transporter
IR208_RS15420	COG2814	Major facilitator Superfamily
IR208_RS15425	COG2197	response regulator
IR208_RS15430	COG3850	Histidine kinase
IR208_RS15435	COG1131	(ABC) transporter
IR208_RS15445	COG0842	Transport permease protein
IR208_RS15470	COG0471	metal ion transport
IR208_RS15495	COG1131	(ABC) transporter
IR208_RS15500	COG1725	Transcriptional regulator
IR208_RS15505	COG1695	Transcriptional regulator
IR208_RS15510	COG3479	Phenolic acid decarboxylase
IR208_RS15515	COG2910	NAD(P)H-binding
IR208_RS15540	COG0425	Belongs to the sulfur carrier protein TusA family
IR208_RS15545	COG2391	methyltransferase activity
IR208_RS15555	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_RS15575	COG1120	ATPase activity
IR208_RS15580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR208_RS15595	COG3620	sequence-specific DNA binding
IR208_RS15610	COG0519	Catalyzes the synthesis of GMP from XMP
IR208_RS15610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IR208_RS15615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IR208_RS15620	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IR208_RS15625	COG1335	isochorismatase
IR208_RS15635	COG4948	Mandelate Racemase Muconate Lactonizing
IR208_RS15645	COG0463	Glycosyl transferase, family 2
IR208_RS15650	COG2246	polysaccharide biosynthetic process
IR208_RS15655	COG0459	protein refolding
IR208_RS15660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IR208_RS15665	COG1266	CAAX protease self-immunity
IR208_RS15675	COG0805	protein transport
IR208_RS15680	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IR208_RS15685	COG0488	(ABC) transporter
IR208_RS15790	COG3091	SprT-like family
IR208_RS15800	COG2183	response to ionizing radiation
IR208_RS15805	COG2208	phosphoserine phosphatase activity
IR208_RS15810	COG1191	sigma factor activity
IR208_RS15815	COG2172	sigma factor antagonist activity
IR208_RS15820	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_RS15825	COG2208	phosphoserine phosphatase activity
IR208_RS15830	COG2172	sigma factor antagonist activity
IR208_RS15835	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_RS15840	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_RS15845	COG2337	Toxic component of a toxin-antitoxin (TA) module
IR208_RS15850	COG0864	Transcriptional regulator
IR208_RS15860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IR208_RS15865	COG0736	holo-[acyl-carrier-protein] synthase activity
IR208_RS15870	COG0705	Rhomboid family
IR208_RS15875	COG0513	Belongs to the DEAD box helicase family
IR208_RS15890	COG1280	lysine exporter protein (LysE YggA)
IR208_RS15895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IR208_RS15900	COG1609	Transcriptional regulator
IR208_RS15905	COG0366	Alpha amylase catalytic
IR208_RS15915	COG2182	Extracellular solute-binding protein
IR208_RS15920	COG1175	transmembrane transport
IR208_RS15925	COG3833	ABC-type maltose transport systems, permease component
IR208_RS15930	COG5521	maltodextrose utilization protein MalA
IR208_RS15935	COG1554	hydrolase, family 65, central catalytic
IR208_RS15945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IR208_RS15950	COG1181	Belongs to the D-alanine--D-alanine ligase family
IR208_RS15960	COG1253	flavin adenine dinucleotide binding
IR208_RS15965	COG0789	Transcriptional regulator
IR208_RS15970	COG1253	flavin adenine dinucleotide binding
IR208_RS15985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IR208_RS16000	COG0629	single-stranded DNA binding
IR208_RS16010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IR208_RS16015	COG4786	Flagellar basal body rod
IR208_RS16020	COG4786	Flagellar basal body rod
IR208_RS16025	COG1077	Cell shape determining protein MreB Mrl
IR208_RS16030	COG1609	Transcriptional regulator
IR208_RS16035	COG0739	heme binding
IR208_RS16040	COG2385	sporulation resulting in formation of a cellular spore
IR208_RS16045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IR208_RS16055	COG4836	Membrane
IR208_RS16060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IR208_RS16065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IR208_RS16070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IR208_RS16075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IR208_RS16080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IR208_RS16090	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IR208_RS16095	COG0356	it plays a direct role in the translocation of protons across the membrane
IR208_RS16105	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IR208_RS16110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IR208_RS16120	COG4475	Protein of unknown function (DUF436)
IR208_RS16125	COG0698	ribose 5-phosphate isomerase
IR208_RS16130	COG0840	transmembrane signaling receptor activity
IR208_RS16140	COG1971	Probably functions as a manganese efflux pump
IR208_RS16145	COG0009	L-threonylcarbamoyladenylate synthase
IR208_RS16160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IR208_RS16170	COG1435	thymidine kinase activity
IR208_RS16175	COG0254	rRNA binding
IR208_RS16180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IR208_RS16185	COG1494	fructose-1,6-bisphosphatase
IR208_RS16190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IR208_RS16195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IR208_RS16200	COG0191	fructose-bisphosphate aldolase activity
IR208_RS16205	COG2204	response regulator
IR208_RS16220	COG1131	(ABC) transporter
IR208_RS16225	COG1725	Transcriptional regulator
IR208_RS16230	COG0504	CTP synthase activity
IR208_RS16235	COG3343	RNA polymerase activity
IR208_RS16240	COG1136	(ABC) transporter
IR208_RS16255	COG1309	transcriptional regulator
IR208_RS16260	COG1960	acyl-CoA dehydrogenase activity
IR208_RS16265	COG1960	acyl-CoA dehydrogenase activity
IR208_RS16270	COG0183	Belongs to the thiolase family
IR208_RS16275	COG0247	lactate metabolic process
IR208_RS16275	COG2181	nitrate reductase activity
IR208_RS16280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IR208_RS16285	COG0018	arginyl-trna synthetase
IR208_RS16295	COG0010	Belongs to the arginase family
IR208_RS16300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IR208_RS16310	COG1994	Peptidase M50
IR208_RS16320	COG3465	dGTPase activity
IR208_RS16325	COG1078	dGTPase activity
IR208_RS16335	COG0095	Lipoate-protein ligase
IR208_RS16340	COG0280	phosphate acetyltransferase
IR208_RS16345	COG3253	May function as heme-dependent peroxidase
IR208_RS16355	COG2363	Small membrane protein
IR208_RS16365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IR208_RS16400	COG4555	ABC transporter
IR208_RS16410	COG1122	ATPase activity
IR208_RS16425	COG0351	phosphomethylpyrimidine kinase
IR208_RS16440	COG0561	phosphatase activity
IR208_RS16445	COG0514	ATP-dependent DNA helicase (RecQ)
IR208_RS16450	COG1785	Belongs to the alkaline phosphatase family
IR208_RS16455	COG1737	Transcriptional regulator
IR208_RS16470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IR208_RS16480	COG1346	cytolysis
IR208_RS16485	COG1380	Effector of murein hydrolase LrgA
IR208_RS16490	COG0583	DNA-binding transcription factor activity
IR208_RS16495	COG0367	asparagine synthase
IR208_RS16515	COG2966	Psort location CytoplasmicMembrane, score
IR208_RS16520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IR208_RS16525	COG1966	Carbon starvation protein
IR208_RS16535	COG3275	phosphorelay sensor kinase activity
IR208_RS16540	COG1464	Belongs to the NlpA lipoprotein family
IR208_RS16545	COG2011	ABC-type metal ion transport system permease component
IR208_RS16550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IR208_RS16555	COG1119	ATPase activity
IR208_RS16570	COG0534	Mate efflux family protein
IR208_RS16575	COG1442	glycosyl transferase family 8
IR208_RS16580	COG2195	Cleaves the N-terminal amino acid of tripeptides
IR208_RS16585	COG2814	Major facilitator Superfamily
IR208_RS16595	COG0028	Belongs to the TPP enzyme family
IR208_RS16615	COG3842	ATPase activity
IR208_RS16635	COG0584	glycerophosphoryl diester phosphodiesterase
IR208_RS16670	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IR208_RS16690	COG2188	Transcriptional regulator
IR208_RS16695	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IR208_RS16700	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_RS16720	COG3457	Alanine racemase
IR208_RS16730	COG1126	abc transporter atp-binding protein
IR208_RS16740	COG0765	amino acid transport
IR208_RS16745	COG0579	oxidoreductase
IR208_RS16750	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IR208_RS16755	COG0732	type I restriction modification DNA specificity domain
IR208_RS16760	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IR208_RS16770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IR208_RS16775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IR208_RS16780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IR208_RS16785	COG4853	Protein conserved in bacteria
IR208_RS16790	COG4863	YycH protein
IR208_RS16795	COG5002	protein histidine kinase activity
IR208_RS16800	COG0745	RESPONSE REGULATOR receiver
IR208_RS16815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IR208_RS16820	COG0305	Participates in initiation and elongation during chromosome replication
IR208_RS16825	COG0359	binds to the 23S rRNA
IR208_RS16830	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IR208_RS16840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IR208_RS16845	COG0629	single-stranded DNA binding
IR208_RS16850	COG0360	Binds together with S18 to 16S ribosomal RNA
IR208_RS16855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IR208_RS16860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IR208_RS16860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IR208_RS16865	COG0307	riboflavin synthase, alpha
IR208_RS16870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IR208_RS16870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IR208_RS16875	COG0012	GTP binding
IR208_RS16880	COG4481	Protein conserved in bacteria
IR208_RS16885	COG0668	transmembrane transport
IR208_RS16900	COG1475	DNA binding
IR208_RS16905	COG1192	Involved in chromosome partitioning
IR208_RS16910	COG1475	DNA binding
IR208_RS16915	COG0357	Ribosomal RNA small subunit methyltransferase G
IR208_RS16920	COG0445	tRNA wobble uridine modification
IR208_RS16925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IR208_RS16930	COG1847	R3H domain protein
IR208_RS16935	COG0706	membrane insertase activity
IR208_RS16940	COG0594	ribonuclease P activity
IR208_RS16945	COG0230	Belongs to the bacterial ribosomal protein bL34 family