locus-tag	class	description
I6J17_RS00005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J17_RS00020	COG2010	Cytochrome c
I6J17_RS00025	COG2384	SAM-dependent methyltransferase
I6J17_RS00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J17_RS00035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J17_RS00045	COG0513	Belongs to the DEAD box helicase family
I6J17_RS00050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J17_RS00055	COG0791	NLP P60 protein
I6J17_RS00055	COG3883	PFAM NLP P60 protein
I6J17_RS00065	COG1121	(ABC) transporter
I6J17_RS00070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J17_RS00075	COG0735	belongs to the Fur family
I6J17_RS00080	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I6J17_RS00085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J17_RS00095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J17_RS00100	COG0477	Major facilitator Superfamily
I6J17_RS00105	COG0768	penicillin binding
I6J17_RS00115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J17_RS00125	COG0705	Rhomboid family
I6J17_RS00125	COG0457	Tetratricopeptide repeat
I6J17_RS00130	COG4483	Protein conserved in bacteria
I6J17_RS00135	COG1940	carbohydrate kinase activity
I6J17_RS00145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J17_RS00160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J17_RS00165	COG1459	type II secretion system
I6J17_RS00170	COG4537	Required for transformation and DNA binding
I6J17_RS00195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J17_RS00210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J17_RS00215	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J17_RS00225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J17_RS00230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J17_RS00235	COG0095	Lipoate-protein ligase
I6J17_RS00240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J17_RS00255	COG0183	Belongs to the thiolase family
I6J17_RS00280	COG3872	metal-dependent enzyme
I6J17_RS00290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J17_RS00295	COG0006	proline dipeptidase activity
I6J17_RS00300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J17_RS00305	COG3854	ATPases associated with a variety of cellular activities
I6J17_RS00345	COG0511	ligase activity, forming carbon-carbon bonds
I6J17_RS00350	COG0439	Biotin carboxylase
I6J17_RS00355	COG1302	Protein conserved in bacteria
I6J17_RS00365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J17_RS00370	COG1570	exodeoxyribonuclease VII activity
I6J17_RS00385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J17_RS00390	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6J17_RS00400	COG0497	DNA recombination
I6J17_RS00405	COG0750	zinc metalloprotease
I6J17_RS00410	COG0745	RESPONSE REGULATOR receiver
I6J17_RS00415	COG0584	glycerophosphoryl diester phosphodiesterase
I6J17_RS00430	COG3829	transcription factor binding
I6J17_RS00430	COG3290	protein histidine kinase activity
I6J17_RS00440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J17_RS00445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J17_RS00450	COG0022	dehydrogenase e1 component
I6J17_RS00455	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J17_RS00460	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J17_RS00470	COG1376	ErfK ybiS ycfS ynhG family protein
I6J17_RS00485	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J17_RS00500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J17_RS00510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J17_RS00515	COG0300	oxidoreductase activity
I6J17_RS00520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J17_RS00530	COG1388	LysM domain
I6J17_RS00530	COG3858	chitin binding
I6J17_RS00535	COG1073	alpha beta
I6J17_RS00540	COG3853	Toxic anion resistance protein (TelA)
I6J17_RS00545	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I6J17_RS00555	COG0667	Aldo Keto reductase
I6J17_RS00570	COG1379	DNA repair
I6J17_RS00575	COG1300	Membrane
I6J17_RS00580	COG0735	belongs to the Fur family
I6J17_RS00590	COG4974	Belongs to the 'phage' integrase family
I6J17_RS00595	COG1686	Belongs to the peptidase S11 family
I6J17_RS00610	COG1191	sigma factor activity
I6J17_RS00630	COG0697	spore germination
I6J17_RS00655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J17_RS00660	COG1686	Belongs to the peptidase S11 family
I6J17_RS00665	COG2715	membrane protein required for spore maturation
I6J17_RS00670	COG0700	Nucleoside recognition
I6J17_RS00675	COG1187	pseudouridine synthase activity
I6J17_RS00680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_RS00685	COG1333	cytochrome c biogenesis protein
I6J17_RS00690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J17_RS00695	COG0745	RESPONSE REGULATOR receiver
I6J17_RS00700	COG5002	protein histidine kinase activity
I6J17_RS00705	COG1196	nuclear chromosome segregation
I6J17_RS00705	COG0741	lytic transglycosylase activity
I6J17_RS00705	COG0739	heme binding
I6J17_RS00710	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6J17_RS00715	COG1141	Ferredoxin
I6J17_RS00730	COG0514	ATP-dependent DNA helicase (RecQ)
I6J17_RS00735	COG1266	CAAX protease self-immunity
I6J17_RS00750	COG3546	catalase activity
I6J17_RS00765	COG1408	metallophosphoesterase
I6J17_RS00775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J17_RS00780	COG0492	ferredoxin-NADP+ reductase activity
I6J17_RS00785	COG2339	peptidase activity
I6J17_RS00790	COG3409	Peptidoglycan-binding domain 1 protein
I6J17_RS00790	COG3773	Cell wall hydrolase
I6J17_RS00795	COG2959	enzyme of heme biosynthesis
I6J17_RS00805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J17_RS00810	COG0539	negative regulation of cytoplasmic translation
I6J17_RS00825	COG1160	GTP binding
I6J17_RS00845	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6J17_RS00850	COG0776	regulation of translation
I6J17_RS00860	COG0142	geranyltranstransferase activity
I6J17_RS00865	COG2226	methyltransferase
I6J17_RS00870	COG0142	geranyltranstransferase activity
I6J17_RS00875	COG0105	UTP biosynthetic process
I6J17_RS00880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6J17_RS00885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J17_RS00890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J17_RS00895	COG4401	Chorismate mutase type I
I6J17_RS00900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J17_RS00905	COG0287	Prephenate dehydrogenase
I6J17_RS00910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J17_RS00915	COG0457	Tetratricopeptide repeat
I6J17_RS00920	COG5582	Belongs to the UPF0302 family
I6J17_RS00935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6J17_RS00945	COG4347	Protein of unknown function (DUF1405)
I6J17_RS00955	COG2738	Putative neutral zinc metallopeptidase
I6J17_RS00965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J17_RS00970	COG1694	Mazg nucleotide pyrophosphohydrolase
I6J17_RS00975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J17_RS00980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J17_RS00985	COG0438	transferase activity, transferring glycosyl groups
I6J17_RS01005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J17_RS01010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J17_RS01015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J17_RS01015	COG1199	ATP-dependent helicase activity
I6J17_RS01030	COG0017	Asparaginyl-tRNA synthetase
I6J17_RS01035	COG3935	DnaD domain protein
I6J17_RS01040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J17_RS01045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J17_RS01045	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6J17_RS01050	COG3331	DNA recombination
I6J17_RS01075	COG0071	Belongs to the small heat shock protein (HSP20) family
I6J17_RS01080	COG1205	dead DEAH box helicase
I6J17_RS01080	COG1111	helicase
I6J17_RS01085	COG3359	exonuclease
I6J17_RS01095	COG4474	Belongs to the UPF0398 family
I6J17_RS01110	COG0116	Belongs to the methyltransferase superfamily
I6J17_RS01115	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6J17_RS01125	COG2233	PERMEase
I6J17_RS01140	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6J17_RS01145	COG0789	Transcriptional regulator
I6J17_RS01150	COG0174	glutamine synthetase
I6J17_RS01155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J17_RS01165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J17_RS01170	COG4224	UPF0291 protein
I6J17_RS01185	COG3763	UPF0154 protein
I6J17_RS01190	COG0785	Cytochrome C biogenesis protein
I6J17_RS01195	COG2201	protein-glutamate methylesterase activity
I6J17_RS01200	COG4846	Membrane protein involved in cytochrome C biogenesis
I6J17_RS01210	COG0204	Acyl-transferase
I6J17_RS01215	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J17_RS01220	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J17_RS01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J17_RS01260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J17_RS01265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J17_RS01270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J17_RS01275	COG0505	Belongs to the CarA family
I6J17_RS01280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J17_RS01285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J17_RS01290	COG0137	argininosuccinate synthase activity
I6J17_RS01295	COG0165	Argininosuccinate lyase
I6J17_RS01300	COG0436	Aminotransferase
I6J17_RS01330	COG0789	Transcriptional regulator
I6J17_RS01335	COG4990	cell redox homeostasis
I6J17_RS01345	COG2404	hydrolase activity, acting on ester bonds
I6J17_RS01350	COG1252	NADH dehydrogenase
I6J17_RS01360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J17_RS01365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J17_RS01370	COG0701	Predicted permease
I6J17_RS01380	COG0709	Synthesizes selenophosphate from selenide and ATP
I6J17_RS01385	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6J17_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS01410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J17_RS01440	COG1131	(ABC) transporter
I6J17_RS01445	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6J17_RS01455	COG0783	Belongs to the Dps family
I6J17_RS01460	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J17_RS01465	COG0494	nUDIX hydrolase
I6J17_RS01470	COG1247	-acetyltransferase
I6J17_RS01490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J17_RS01495	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6J17_RS01500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6J17_RS01505	COG0297	glycogen (starch) synthase activity
I6J17_RS01515	COG0708	Exodeoxyribonuclease III
I6J17_RS01520	COG3773	Cell wall hydrolase
I6J17_RS01525	COG2223	nitrite transmembrane transporter activity
I6J17_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS01570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J17_RS01575	COG0798	PFAM Bile acid sodium symporter
I6J17_RS01580	COG0640	Transcriptional regulator
I6J17_RS01615	COG0583	DNA-binding transcription factor activity
I6J17_RS01635	COG0589	response to stress
I6J17_RS01655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J17_RS01655	COG0475	glutathione-regulated potassium exporter activity
I6J17_RS01660	COG0039	L-malate dehydrogenase activity
I6J17_RS01675	COG2322	membrane
I6J17_RS01700	COG0561	phosphatase activity
I6J17_RS01710	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_RS01715	COG0183	Belongs to the thiolase family
I6J17_RS01730	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J17_RS01745	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6J17_RS01745	COG3264	Mechanosensitive ion channel
I6J17_RS01750	COG3284	Transcriptional regulator
I6J17_RS01755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J17_RS01760	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J17_RS01765	COG0022	dehydrogenase e1 component
I6J17_RS01770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J17_RS01775	COG0697	spore germination
I6J17_RS01780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J17_RS01805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J17_RS01810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J17_RS01815	COG2045	Belongs to the ComB family
I6J17_RS01830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J17_RS01835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J17_RS01850	COG1309	transcriptional regulator
I6J17_RS01890	COG2258	MOSC domain
I6J17_RS01900	COG0352	thiamine-phosphate diphosphorylase activity
I6J17_RS01905	COG0351	phosphomethylpyrimidine kinase
I6J17_RS01910	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6J17_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS01925	COG0456	acetyltransferase
I6J17_RS01935	COG0456	acetyltransferase
I6J17_RS01950	COG0681	Belongs to the peptidase S26 family
I6J17_RS01955	COG2070	2-Nitropropane dioxygenase
I6J17_RS01975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J17_RS01975	COG0574	Belongs to the PEP-utilizing enzyme family
I6J17_RS01980	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6J17_RS01995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J17_RS02000	COG0187	DNA topoisomerase II activity
I6J17_RS02005	COG1832	CoA-binding protein
I6J17_RS02010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6J17_RS02015	COG4841	protein insertion into membrane
I6J17_RS02025	COG0824	Thioesterase
I6J17_RS02045	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J17_RS02055	COG2309	aminopeptidase activity
I6J17_RS02080	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_RS02085	COG1346	cytolysis
I6J17_RS02090	COG1380	Effector of murein hydrolase LrgA
I6J17_RS02100	COG1132	(ABC) transporter
I6J17_RS02105	COG1132	(ABC) transporter
I6J17_RS02115	COG0477	Major facilitator Superfamily
I6J17_RS02125	COG1113	amino acid transport
I6J17_RS02130	COG0745	RESPONSE REGULATOR receiver
I6J17_RS02135	COG0642	Histidine kinase
I6J17_RS02140	COG1136	(ABC) transporter
I6J17_RS02145	COG0577	efflux transmembrane transporter activity
I6J17_RS02160	COG3634	alkyl hydroperoxide reductase activity
I6J17_RS02165	COG0302	gtp cyclohydrolase
I6J17_RS02170	COG1278	Cold shock
I6J17_RS02180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J17_RS02190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J17_RS02195	COG2807	transmembrane transport
I6J17_RS02215	COG0569	domain protein
I6J17_RS02220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J17_RS02225	COG2962	Rard protein
I6J17_RS02230	COG2391	methyltransferase activity
I6J17_RS02240	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J17_RS02240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J17_RS02255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J17_RS02260	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J17_RS02270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J17_RS02275	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6J17_RS02285	COG0598	Magnesium transport protein CorA
I6J17_RS02290	COG1113	amino acid transport
I6J17_RS02295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J17_RS02300	COG1388	LysM domain
I6J17_RS02300	COG3584	3D domain protein
I6J17_RS02310	COG0516	GMP reductase activity
I6J17_RS02310	COG0517	IMP dehydrogenase activity
I6J17_RS02315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J17_RS02325	COG2135	peptidase activity
I6J17_RS02330	COG1054	Belongs to the UPF0176 family
I6J17_RS02340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J17_RS02360	COG1012	belongs to the aldehyde dehydrogenase family
I6J17_RS02365	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J17_RS02370	COG0567	Dehydrogenase, E1 component
I6J17_RS02385	COG5002	protein histidine kinase activity
I6J17_RS02390	COG0745	RESPONSE REGULATOR receiver
I6J17_RS02400	COG2814	Major facilitator Superfamily
I6J17_RS02405	COG1331	Highly conserved protein containing a thioredoxin domain
I6J17_RS02410	COG1368	sulfuric ester hydrolase activity
I6J17_RS02415	COG0671	phosphoesterase, PA-phosphatase related
I6J17_RS02420	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J17_RS02425	COG1793	dna ligase
I6J17_RS02425	COG3285	dna ligase
I6J17_RS02440	COG0534	Mate efflux family protein
I6J17_RS02445	COG2340	Cysteine-rich secretory protein family
I6J17_RS02450	COG1846	Transcriptional regulator
I6J17_RS02455	COG3409	Peptidoglycan-binding domain 1 protein
I6J17_RS02455	COG0793	Belongs to the peptidase S41A family
I6J17_RS02460	COG1876	peptidase activity
I6J17_RS02475	COG4479	Belongs to the UPF0346 family
I6J17_RS02480	COG0840	transmembrane signaling receptor activity
I6J17_RS02490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J17_RS02495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J17_RS02500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J17_RS02500	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6J17_RS02510	COG2755	lipolytic protein G-D-S-L family
I6J17_RS02515	COG1272	protein, Hemolysin III
I6J17_RS02520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J17_RS02525	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6J17_RS02540	COG1413	lyase activity
I6J17_RS02545	COG0488	(ABC) transporter
I6J17_RS02555	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6J17_RS02560	COG1321	iron dependent repressor
I6J17_RS02585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J17_RS02590	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6J17_RS02595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J17_RS02600	COG0464	growth
I6J17_RS02610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J17_RS02630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J17_RS02635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6J17_RS02645	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6J17_RS02650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J17_RS02655	COG0531	amino acid
I6J17_RS02660	COG0826	peptidase U32
I6J17_RS02665	COG0826	peptidase U32
I6J17_RS02670	COG2359	stage V sporulation protein S
I6J17_RS02675	COG1692	metallophosphoesterase
I6J17_RS02680	COG1418	mRNA catabolic process
I6J17_RS02690	COG1058	Belongs to the CinA family
I6J17_RS02690	COG1546	Belongs to the CinA family
I6J17_RS02695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J17_RS02700	COG1426	Protein conserved in bacteria
I6J17_RS02715	COG0300	oxidoreductase activity
I6J17_RS02720	COG0612	Peptidase, M16
I6J17_RS02725	COG0612	Peptidase, M16
I6J17_RS02730	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J17_RS02735	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6J17_RS02740	COG3845	ABC transporter
I6J17_RS02745	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J17_RS02750	COG1674	ftsk spoiiie
I6J17_RS02750	COG4980	gas vesicle protein
I6J17_RS02760	COG0740	serine-type endopeptidase activity
I6J17_RS02765	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J17_RS02775	COG0527	aspartate kinase activity
I6J17_RS02780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J17_RS02785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J17_RS02790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J17_RS02795	COG1873	PFAM PRC-barrel domain
I6J17_RS02800	COG0612	Peptidase, M16
I6J17_RS02805	COG0726	polysaccharide deacetylase
I6J17_RS02810	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J17_RS02815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J17_RS02820	COG0196	riboflavin kinase activity
I6J17_RS02825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J17_RS02830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J17_RS02835	COG1550	Protein conserved in bacteria
I6J17_RS02845	COG1358	cellular component organization or biogenesis
I6J17_RS02850	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6J17_RS02855	COG0195	Participates in both transcription termination and antitermination
I6J17_RS02860	COG0779	Required for maturation of 30S ribosomal subunits
I6J17_RS02865	COG2176	DNA-directed DNA polymerase activity
I6J17_RS02870	COG0442	prolyl-tRNA aminoacylation
I6J17_RS02875	COG0750	zinc metalloprotease
I6J17_RS02880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J17_RS02885	COG4589	Belongs to the CDS family
I6J17_RS02890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J17_RS02895	COG0233	cytoplasmic translational termination
I6J17_RS02900	COG0528	UMP kinase activity
I6J17_RS02905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J17_RS02910	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J17_RS02920	COG1191	sigma factor activity
I6J17_RS02925	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6J17_RS02930	COG1776	CheC inhibitor of MCP methylation
I6J17_RS02935	COG0835	chemotaxis
I6J17_RS02940	COG2198	Histidine kinase
I6J17_RS02940	COG0643	Histidine kinase
I6J17_RS02945	COG2201	protein-glutamate methylesterase activity
I6J17_RS02950	COG0455	bacterial-type flagellum organization
I6J17_RS02955	COG1419	protein localization to endoplasmic reticulum
I6J17_RS02960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J17_RS02965	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J17_RS02970	COG1684	flagellar biosynthetic protein fliR
I6J17_RS02975	COG1987	bacterial-type flagellum assembly
I6J17_RS02980	COG1338	Plays a role in the flagellum-specific transport system
I6J17_RS02985	COG3190	flagellar
I6J17_RS02990	COG2201	protein-glutamate methylesterase activity
I6J17_RS02995	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J17_RS02995	COG1776	CheC inhibitor of MCP methylation
I6J17_RS03000	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J17_RS03005	COG1580	Controls the rotational direction of flagella during chemotaxis
I6J17_RS03015	COG4786	Flagellar basal body rod
I6J17_RS03025	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6J17_RS03040	COG2882	bacterial-type flagellum organization
I6J17_RS03045	COG1157	protein secretion by the type III secretion system
I6J17_RS03050	COG1317	bacterial-type flagellum organization
I6J17_RS03055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J17_RS03060	COG1766	The M ring may be actively involved in energy transduction
I6J17_RS03065	COG1677	Flagellar hook-basal body complex protein FliE
I6J17_RS03070	COG1558	bacterial-type flagellum-dependent cell motility
I6J17_RS03075	COG1815	bacterial-type flagellum-dependent cell motility
I6J17_RS03080	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6J17_RS03090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6J17_RS03095	COG4974	Belongs to the 'phage' integrase family
I6J17_RS03100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J17_RS03110	COG0758	DNA mediated transformation
I6J17_RS03115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J17_RS03120	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J17_RS03125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J17_RS03140	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6J17_RS03155	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J17_RS03160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J17_RS03170	COG1837	Belongs to the UPF0109 family
I6J17_RS03180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J17_RS03185	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6J17_RS03190	COG0552	protein localization to endoplasmic reticulum
I6J17_RS03195	COG1196	nuclear chromosome segregation
I6J17_RS03200	COG0571	ribonuclease III activity
I6J17_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS03215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J17_RS03220	COG0416	fatty acid biosynthetic process
I6J17_RS03225	COG1349	DNA-binding transcription factor activity
I6J17_RS03230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J17_RS03235	COG1760	l-serine dehydratase
I6J17_RS03240	COG1760	l-serine dehydratase
I6J17_RS03245	COG1461	Dihydroxyacetone kinase
I6J17_RS03250	COG1302	Protein conserved in bacteria
I6J17_RS03260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J17_RS03270	COG1564	THIamine pyrophosphokinase
I6J17_RS03275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J17_RS03280	COG1162	GTPase activity
I6J17_RS03285	COG0515	serine threonine protein kinase
I6J17_RS03285	COG2815	serine threonine protein kinase
I6J17_RS03290	COG0631	protein serine/threonine phosphatase activity
I6J17_RS03295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J17_RS03295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J17_RS03300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J17_RS03305	COG0242	peptide deformylase activity
I6J17_RS03310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J17_RS03315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J17_RS03320	COG1758	RNA polymerase activity
I6J17_RS03325	COG0194	GDP metabolic process
I6J17_RS03330	COG2052	Domain of unknown function (DUF370)
I6J17_RS03335	COG1561	YicC-like family, N-terminal region
I6J17_RS03340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J17_RS03350	COG0385	Bile acid
I6J17_RS03365	COG0628	permease
I6J17_RS03370	COG0477	Major facilitator Superfamily
I6J17_RS03375	COG0477	Major facilitator Superfamily
I6J17_RS03380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J17_RS03395	COG1803	Methylglyoxal synthase
I6J17_RS03420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J17_RS03430	COG0167	dihydroorotate dehydrogenase activity
I6J17_RS03435	COG0543	2 iron, 2 sulfur cluster binding
I6J17_RS03450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J17_RS03455	COG0540	Belongs to the ATCase OTCase family
I6J17_RS03460	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J17_RS03465	COG0564	pseudouridine synthase activity
I6J17_RS03470	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J17_RS03485	COG3599	regulation of cell shape
I6J17_RS03490	COG2302	S4 RNA-binding domain
I6J17_RS03495	COG0762	integral membrane protein
I6J17_RS03500	COG1799	cell septum assembly
I6J17_RS03505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J17_RS03515	COG3584	3D domain protein
I6J17_RS03515	COG1388	LysM domain
I6J17_RS03520	COG1873	PFAM PRC-barrel domain
I6J17_RS03525	COG1191	sigma factor activity
I6J17_RS03530	COG1191	sigma factor activity
I6J17_RS03540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J17_RS03545	COG0849	cell division
I6J17_RS03550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J17_RS03555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J17_RS03560	COG0772	Belongs to the SEDS family
I6J17_RS03565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J17_RS03570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J17_RS03585	COG0768	penicillin binding
I6J17_RS03590	COG0768	penicillin binding
I6J17_RS03595	COG4839	cell division protein FtsL
I6J17_RS03600	COG0275	rRNA processing
I6J17_RS03605	COG2001	Belongs to the MraZ family
I6J17_RS03610	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I6J17_RS03615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J17_RS03620	COG0454	-acetyltransferase
I6J17_RS03630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J17_RS03635	COG1399	metal-binding, possibly nucleic acid-binding protein
I6J17_RS03640	COG1323	Belongs to the UPF0348 family
I6J17_RS03645	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J17_RS03650	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J17_RS03655	COG3314	Sporulation integral membrane protein YlbJ
I6J17_RS03660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J17_RS03665	COG0742	ribosomal rna small subunit methyltransferase
I6J17_RS03675	COG4471	UPF0298 protein
I6J17_RS03680	COG3679	Belongs to the UPF0342 family
I6J17_RS03705	COG2340	Cysteine-rich secretory protein family
I6J17_RS03715	COG3336	cytochrome c oxidase
I6J17_RS03720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J17_RS03735	COG2010	Cytochrome c
I6J17_RS03735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J17_RS03740	COG0109	protoheme IX farnesyltransferase activity
I6J17_RS03745	COG1612	heme a metabolic process
I6J17_RS03750	COG0772	Belongs to the SEDS family
I6J17_RS03755	COG4838	Belongs to the UPF0358 family
I6J17_RS03760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J17_RS03765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J17_RS03775	COG1217	gtp-binding protein TYPA
I6J17_RS03785	COG0483	inositol monophosphate 1-phosphatase activity
I6J17_RS03805	COG1982	Orn Lys Arg decarboxylase major
I6J17_RS03845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J17_RS03855	COG1473	amidohydrolase
I6J17_RS03860	COG2171	N-acyltransferase activity
I6J17_RS03865	COG0583	DNA-binding transcription factor activity
I6J17_RS03870	COG0517	IMP dehydrogenase activity
I6J17_RS03875	COG4703	Protein of unknown function (DUF1797)
I6J17_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS03905	COG2409	Drug exporters of the RND superfamily
I6J17_RS03905	COG1033	growth of symbiont in host cell
I6J17_RS03915	COG0835	chemotaxis
I6J17_RS03915	COG0784	Response regulator, receiver
I6J17_RS03920	COG0436	Aminotransferase
I6J17_RS03925	COG2084	Dehydrogenase
I6J17_RS03940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J17_RS03950	COG4873	Protein conserved in bacteria
I6J17_RS03960	COG3949	Membrane
I6J17_RS03965	COG0542	response to heat
I6J17_RS03980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J17_RS03985	COG5002	protein histidine kinase activity
I6J17_RS04000	COG0861	Integral membrane protein TerC family
I6J17_RS04010	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J17_RS04015	COG3852	Histidine kinase
I6J17_RS04020	COG0673	inositol 2-dehydrogenase activity
I6J17_RS04025	COG0783	Belongs to the Dps family
I6J17_RS04030	COG0730	response to heat
I6J17_RS04040	COG1959	2 iron, 2 sulfur cluster binding
I6J17_RS04050	COG0477	Major facilitator Superfamily
I6J17_RS04100	COG2323	membrane
I6J17_RS04135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J17_RS04140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J17_RS04160	COG1522	sequence-specific DNA binding
I6J17_RS04165	COG2059	Chromate
I6J17_RS04170	COG2059	Chromate
I6J17_RS04175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J17_RS04190	COG3579	cysteine-type endopeptidase activity
I6J17_RS04200	COG1668	transmembrane transport
I6J17_RS04205	COG4152	abc transporter atp-binding protein
I6J17_RS04215	COG1940	carbohydrate kinase activity
I6J17_RS04235	COG2382	esterase
I6J17_RS04245	COG2153	protein acetylation
I6J17_RS04270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J17_RS04305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J17_RS04310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J17_RS04315	COG0564	pseudouridine synthase activity
I6J17_RS04325	COG2357	RelA SpoT domain protein
I6J17_RS04335	COG4116	CYTH
I6J17_RS04340	COG0741	lytic transglycosylase activity
I6J17_RS04345	COG2346	COG2346, Truncated hemoglobins
I6J17_RS04350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J17_RS04360	COG1164	Oligoendopeptidase f
I6J17_RS04365	COG4469	Competence protein
I6J17_RS04370	COG4862	establishment of competence for transformation
I6J17_RS04375	COG1393	Belongs to the ArsC family
I6J17_RS04380	COG4608	Belongs to the ABC transporter superfamily
I6J17_RS04385	COG0444	Belongs to the ABC transporter superfamily
I6J17_RS04390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J17_RS04395	COG0601	transmembrane transport
I6J17_RS04400	COG4166	transmembrane transport
I6J17_RS04415	COG0180	Tryptophanyl-tRNA synthetase
I6J17_RS04435	COG0601	transmembrane transport
I6J17_RS04440	COG4608	Belongs to the ABC transporter superfamily
I6J17_RS04455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J17_RS04460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J17_RS04495	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J17_RS04500	COG0561	phosphatase activity
I6J17_RS04510	COG1307	EDD domain protein, DegV family
I6J17_RS04530	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J17_RS04535	COG2311	Membrane
I6J17_RS04570	COG1074	ATP-dependent DNA helicase activity
I6J17_RS04575	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6J17_RS04585	COG4903	ComK protein
I6J17_RS04595	COG0501	Belongs to the peptidase M48B family
I6J17_RS04605	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J17_RS04610	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_RS04615	COG0095	Lipoate-protein ligase
I6J17_RS04630	COG1999	signal sequence binding
I6J17_RS04640	COG0697	spore germination
I6J17_RS04645	COG2814	Major facilitator Superfamily
I6J17_RS04650	COG1511	domain protein
I6J17_RS04655	COG1309	transcriptional regulator
I6J17_RS04660	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J17_RS04665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J17_RS04670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J17_RS04675	COG2329	Antibiotic biosynthesis monooxygenase
I6J17_RS04680	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J17_RS04685	COG1473	amidohydrolase
I6J17_RS04695	COG4473	ABC transporter
I6J17_RS04700	COG1131	(ABC) transporter
I6J17_RS04705	COG0537	adenosine 5'-monophosphoramidase activity
I6J17_RS04725	COG1846	Transcriptional regulator
I6J17_RS04740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J17_RS04750	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6J17_RS04755	COG4717	serine-type aminopeptidase activity
I6J17_RS04760	COG0420	3'-5' exonuclease activity
I6J17_RS04765	COG3689	TIGRFAM TIGR03943 family protein
I6J17_RS04770	COG0701	Predicted permease
I6J17_RS04775	COG0861	Integral membrane protein TerC family
I6J17_RS04785	COG1024	Enoyl-CoA hydratase
I6J17_RS04790	COG0561	phosphatase activity
I6J17_RS04800	COG4399	Belongs to the UPF0754 family
I6J17_RS04810	COG0189	ligase activity
I6J17_RS04815	COG0189	ligase activity
I6J17_RS04825	COG2508	Transcriptional regulator
I6J17_RS04830	COG3842	ATPase activity
I6J17_RS04870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J17_RS04875	COG1481	regulation of sporulation
I6J17_RS04880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J17_RS04885	COG1660	Displays ATPase and GTPase activities
I6J17_RS04890	COG1051	belongs to the nudix hydrolase family
I6J17_RS04895	COG0492	ferredoxin-NADP+ reductase activity
I6J17_RS04900	COG0457	Tetratricopeptide repeat
I6J17_RS04905	COG0110	maltose O-acetyltransferase activity
I6J17_RS04910	COG0546	phosphoglycolate phosphatase activity
I6J17_RS04920	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6J17_RS04930	COG3595	metallopeptidase activity
I6J17_RS04940	COG1682	transport, permease protein
I6J17_RS04945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J17_RS04955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J17_RS04995	COG0463	Glycosyl transferase, family 2
I6J17_RS05005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J17_RS05010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J17_RS05015	COG0556	nucleotide-excision repair
I6J17_RS05040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J17_RS05045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J17_RS05050	COG0581	inorganic phosphate transmembrane transporter activity
I6J17_RS05055	COG0573	inorganic phosphate transmembrane transporter activity
I6J17_RS05065	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J17_RS05070	COG5002	protein histidine kinase activity
I6J17_RS05075	COG0745	RESPONSE REGULATOR receiver
I6J17_RS05095	COG4607	ABC-type enterochelin transport system periplasmic component
I6J17_RS05100	COG4604	ABC transporter, ATP-binding protein
I6J17_RS05105	COG4605	iron ion homeostasis
I6J17_RS05110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J17_RS05115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J17_RS05120	COG3409	Peptidoglycan-binding domain 1 protein
I6J17_RS05120	COG0793	Belongs to the peptidase S41A family
I6J17_RS05125	COG0460	homoserine dehydrogenase
I6J17_RS05140	COG0739	heme binding
I6J17_RS05145	COG2177	Part of the ABC transporter FtsEX involved in
I6J17_RS05150	COG2884	Cell division ATP-binding protein ftsE
I6J17_RS05160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J17_RS05170	COG0653	protein targeting
I6J17_RS05190	COG0405	Gamma-glutamyltransferase
I6J17_RS05205	COG1516	flagellar protein fliS
I6J17_RS05210	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6J17_RS05215	COG1334	flagellar protein FlaG
I6J17_RS05225	COG2094	Belongs to the DNA glycosylase MPG family
I6J17_RS05275	COG1067	ATP-dependent peptidase activity
I6J17_RS05280	COG1113	amino acid transport
I6J17_RS05285	COG2271	Major facilitator Superfamily
I6J17_RS05295	COG0647	UMP catabolic process
I6J17_RS05300	COG1285	pathogenesis
I6J17_RS05305	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6J17_RS05330	COG0653	protein targeting
I6J17_RS05335	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6J17_RS05345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6J17_RS05350	COG1256	bacterial-type flagellum assembly
I6J17_RS05350	COG4786	Flagellar basal body rod
I6J17_RS05360	COG2747	anti-sigma28 factor FlgM
I6J17_RS05370	COG1040	competence protein
I6J17_RS05375	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6J17_RS05380	COG1307	EDD domain protein, DegV family
I6J17_RS05385	COG0531	amino acid
I6J17_RS05390	COG2197	response regulator
I6J17_RS05400	COG1739	Uncharacterized protein family UPF0029
I6J17_RS05405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J17_RS05410	COG0768	penicillin binding
I6J17_RS05420	COG0791	NLP P60 protein
I6J17_RS05420	COG1388	LysM domain
I6J17_RS05425	COG2188	Transcriptional regulator
I6J17_RS05435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J17_RS05440	COG0477	Major facilitator Superfamily
I6J17_RS05450	COG1482	cell wall glycoprotein biosynthetic process
I6J17_RS05455	COG0346	lactoylglutathione lyase activity
I6J17_RS05460	COG2996	Protein conserved in bacteria
I6J17_RS05480	COG1609	Transcriptional regulator
I6J17_RS05485	COG2017	converts alpha-aldose to the beta-anomer
I6J17_RS05490	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6J17_RS05495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J17_RS05510	COG1960	acyl-CoA dehydrogenase activity
I6J17_RS05525	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6J17_RS05540	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J17_RS05545	COG1090	epimerase
I6J17_RS05555	COG2226	methyltransferase
I6J17_RS05565	COG0798	PFAM Bile acid sodium symporter
I6J17_RS05615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J17_RS05625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J17_RS05630	COG0436	Aminotransferase
I6J17_RS05635	COG0789	Transcriptional regulator
I6J17_RS05640	COG0534	Mate efflux family protein
I6J17_RS05645	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J17_RS05655	COG4717	serine-type aminopeptidase activity
I6J17_RS05660	COG0420	3'-5' exonuclease activity
I6J17_RS05675	COG0431	NADPH-dependent FMN reductase
I6J17_RS05700	COG0561	phosphatase activity
I6J17_RS05710	COG0535	radical SAM domain protein
I6J17_RS05725	COG0589	response to stress
I6J17_RS05730	COG2244	polysaccharide biosynthetic process
I6J17_RS05735	COG2746	aminoglycoside 3-N-acetyltransferase activity
I6J17_RS05740	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS05780	COG1268	BioY protein
I6J17_RS05785	COG0024	Methionine aminopeptidase
I6J17_RS05790	COG0791	NLP P60 protein
I6J17_RS05790	COG1388	LysM domain
I6J17_RS05805	COG1454	alcohol dehydrogenase
I6J17_RS05805	COG1012	belongs to the aldehyde dehydrogenase family
I6J17_RS05820	COG4145	pantothenate transmembrane transporter activity
I6J17_RS05830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J17_RS05835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J17_RS05845	COG0010	Belongs to the arginase family
I6J17_RS05850	COG0460	homoserine dehydrogenase
I6J17_RS05855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J17_RS05860	COG0083	homoserine kinase activity
I6J17_RS05865	COG1116	anion transmembrane transporter activity
I6J17_RS05870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J17_RS05875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J17_RS05885	COG0154	amidase activity
I6J17_RS05895	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6J17_RS05900	COG2079	MmgE PrpD family protein
I6J17_RS05915	COG3716	PTS system mannose fructose sorbose family IID component
I6J17_RS05920	COG3715	PTS system
I6J17_RS05930	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J17_RS05930	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J17_RS05935	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6J17_RS05935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6J17_RS05945	COG2706	6-phosphogluconolactonase activity
I6J17_RS05950	COG0011	TIGRFAM Protein of
I6J17_RS05965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J17_RS05975	COG3584	3D domain protein
I6J17_RS05975	COG1388	LysM domain
I6J17_RS05990	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6J17_RS05995	COG1609	Transcriptional regulator
I6J17_RS06005	COG1554	hydrolase, family 65, central catalytic
I6J17_RS06010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J17_RS06015	COG2801	Transposase and inactivated derivatives
I6J17_RS06020	COG1316	TRANSCRIPTIONal
I6J17_RS06025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J17_RS06035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J17_RS06045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J17_RS06070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J17_RS06075	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6J17_RS06080	COG0604	alcohol dehydrogenase
I6J17_RS06095	COG2207	Transcriptional regulator
I6J17_RS06100	COG1653	transport
I6J17_RS06120	COG0626	cystathionine gamma-synthase activity
I6J17_RS06125	COG0626	cystathionine gamma-synthase activity
I6J17_RS06135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6J17_RS06140	COG3711	transcriptional antiterminator
I6J17_RS06140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J17_RS06150	COG2723	6-phospho-beta-galactosidase activity
I6J17_RS06155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J17_RS06155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J17_RS06180	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J17_RS06230	COG2186	Transcriptional regulator
I6J17_RS06235	COG1620	l-lactate permease
I6J17_RS06255	COG1363	Peptidase, m42
I6J17_RS06260	COG0737	Belongs to the 5'-nucleotidase family
I6J17_RS06265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J17_RS06315	COG0584	glycerophosphoryl diester phosphodiesterase
I6J17_RS06350	COG4720	Psort location CytoplasmicMembrane, score
I6J17_RS06365	COG2116	formate transmembrane transporter activity
I6J17_RS06380	COG1131	(ABC) transporter
I6J17_RS06400	COG1104	cysteine desulfurase activity
I6J17_RS06405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J17_RS06410	COG0157	Belongs to the NadC ModD family
I6J17_RS06420	COG0371	Dehydrogenase
I6J17_RS06435	COG0606	chelatase, subunit chli
I6J17_RS06440	COG2272	Belongs to the type-B carboxylesterase lipase family
I6J17_RS06445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J17_RS06455	COG4297	protein containing double-stranded beta helix domain
I6J17_RS06470	COG0110	maltose O-acetyltransferase activity
I6J17_RS06475	COG1510	regulation of RNA biosynthetic process
I6J17_RS06480	COG1125	glycine betaine transport
I6J17_RS06480	COG0517	IMP dehydrogenase activity
I6J17_RS06485	COG1174	glycine betaine transport
I6J17_RS06490	COG1732	Glycine betaine
I6J17_RS06495	COG1174	glycine betaine transport
I6J17_RS06510	COG1609	Transcriptional regulator
I6J17_RS06515	COG2814	Major facilitator Superfamily
I6J17_RS06540	COG2814	Major facilitator Superfamily
I6J17_RS06555	COG2190	(PTS) system
I6J17_RS06555	COG2211	Major facilitator Superfamily
I6J17_RS06585	COG2130	NADP-dependent
I6J17_RS06590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J17_RS06605	COG4989	oxidoreductase activity
I6J17_RS06615	COG1316	TRANSCRIPTIONal
I6J17_RS06625	COG0531	amino acid
I6J17_RS06685	COG0658	competence protein
I6J17_RS06685	COG2333	competence protein COMEC
I6J17_RS06695	COG2315	Protein conserved in bacteria
I6J17_RS06720	COG5263	repeat protein
I6J17_RS06720	COG0366	Alpha amylase catalytic
I6J17_RS06740	COG5504	Zn-dependent protease
I6J17_RS06755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J17_RS06760	COG4193	domain, Protein
I6J17_RS06775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J17_RS06780	COG1063	alcohol dehydrogenase
I6J17_RS06785	COG1070	Carbohydrate kinase
I6J17_RS06850	COG1442	glycosyl transferase family 8
I6J17_RS06850	COG1216	Glycosyl transferase, family 2
I6J17_RS06855	COG1216	Glycosyl transferase, family 2
I6J17_RS06855	COG1442	glycosyl transferase family 8
I6J17_RS06870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J17_RS06875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J17_RS06880	COG4464	protein tyrosine phosphatase activity
I6J17_RS06885	COG0489	protein tyrosine kinase activity
I6J17_RS06890	COG3944	biosynthesis protein
I6J17_RS06915	COG1410	methionine synthase
I6J17_RS06915	COG0646	methionine synthase
I6J17_RS06920	COG0646	methionine synthase
I6J17_RS06920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J17_RS06935	COG0586	Pfam SNARE associated Golgi protein
I6J17_RS06940	COG0586	Pfam SNARE associated Golgi protein
I6J17_RS06950	COG1733	regulation of RNA biosynthetic process
I6J17_RS06965	COG0765	amino acid transport
I6J17_RS06970	COG0765	amino acid transport
I6J17_RS06975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J17_RS06990	COG0628	permease
I6J17_RS06995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J17_RS07005	COG0531	amino acid
I6J17_RS07010	COG0423	glycine-tRNA ligase activity
I6J17_RS07025	COG1902	pentaerythritol trinitrate reductase activity
I6J17_RS07050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J17_RS07055	COG1301	dicarboxylic acid transport
I6J17_RS07060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J17_RS07065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J17_RS07070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J17_RS07075	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6J17_RS07120	COG3973	AAA domain
I6J17_RS07125	COG0463	Glycosyl transferase, family 2
I6J17_RS07130	COG2851	Citrate transporter
I6J17_RS07135	COG4565	transcriptional regulatory protein
I6J17_RS07140	COG3290	protein histidine kinase activity
I6J17_RS07145	COG0004	ammonium transporteR
I6J17_RS07150	COG1979	alcohol dehydrogenase
I6J17_RS07155	COG0531	amino acid
I6J17_RS07160	COG0247	lactate metabolic process
I6J17_RS07165	COG1139	Iron-sulfur cluster binding protein
I6J17_RS07170	COG1556	Lactate utilization protein
I6J17_RS07175	COG0531	amino acid
I6J17_RS07190	COG1177	transmembrane transport
I6J17_RS07195	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J17_RS07200	COG3842	ATPase activity
I6J17_RS07210	COG0833	amino acid
I6J17_RS07215	COG3104	oligopeptide transport
I6J17_RS07220	COG1113	amino acid transport
I6J17_RS07230	COG0667	Aldo Keto reductase
I6J17_RS07235	COG5577	PFAM Coat F domain
I6J17_RS07240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J17_RS07245	COG1609	Transcriptional regulator
I6J17_RS07260	COG2848	UPF0210 protein
I6J17_RS07280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J17_RS07295	COG0702	epimerase
I6J17_RS07310	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J17_RS07315	COG1442	glycosyl transferase family 8
I6J17_RS07315	COG1216	Glycosyl transferase, family 2
I6J17_RS07340	COG0697	spore germination
I6J17_RS07355	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_RS07370	COG0371	Dehydrogenase
I6J17_RS07380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J17_RS07400	COG0175	sulfate reduction
I6J17_RS07410	COG5434	Belongs to the glycosyl hydrolase 28 family
I6J17_RS07425	COG1012	belongs to the aldehyde dehydrogenase family
I6J17_RS07440	COG3226	Transcriptional regulator
I6J17_RS07520	COG1309	transcriptional regulator
I6J17_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS07535	COG1960	acyl-CoA dehydrogenase activity
I6J17_RS07540	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_RS07545	COG0217	transcriptional regulatory protein
I6J17_RS07565	COG1120	ATPase activity
I6J17_RS07570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J17_RS07575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J17_RS07580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J17_RS07590	COG2076	Multidrug Resistance protein
I6J17_RS07595	COG2076	Multidrug Resistance protein
I6J17_RS07610	COG1215	transferase activity, transferring glycosyl groups
I6J17_RS07615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6J17_RS07620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J17_RS07630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J17_RS07640	COG2217	Heavy metal translocating P-type atpase
I6J17_RS07645	COG2217	Heavy metal translocating P-type atpase
I6J17_RS07650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J17_RS07655	COG0322	excinuclease ABC activity
I6J17_RS07660	COG0716	FMN binding
I6J17_RS07665	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6J17_RS07675	COG1070	Carbohydrate kinase
I6J17_RS07685	COG2188	Transcriptional regulator
I6J17_RS07690	COG0366	Alpha amylase catalytic
I6J17_RS07695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J17_RS07695	COG1263	PTS System
I6J17_RS07700	COG2190	(PTS) system
I6J17_RS07705	COG1174	glycine betaine transport
I6J17_RS07710	COG1125	glycine betaine transport
I6J17_RS07710	COG0517	IMP dehydrogenase activity
I6J17_RS07730	COG0183	Belongs to the thiolase family
I6J17_RS07735	COG3425	synthase
I6J17_RS07780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J17_RS07795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J17_RS07805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J17_RS07810	COG4856	YbbR-like protein
I6J17_RS07815	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6J17_RS07835	COG5662	AntiSigma factor
I6J17_RS07865	COG2333	competence protein COMEC
I6J17_RS07865	COG0658	competence protein
I6J17_RS08015	COG5484	DNA packaging
I6J17_RS08025	COG3677	Transposase
I6J17_RS08030	COG0175	sulfate reduction
I6J17_RS08115	COG3723	Recombinational DNA repair protein, rece pathway
I6J17_RS08120	COG5377	YqaJ viral recombinase family
I6J17_RS08160	COG3617	BRO family, N-terminal domain
I6J17_RS08185	COG1525	nuclease
I6J17_RS08255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6J17_RS08260	COG4988	ABC transporter
I6J17_RS08265	COG1294	oxidase, subunit
I6J17_RS08270	COG1271	oxidase subunit
I6J17_RS08280	COG0726	polysaccharide deacetylase
I6J17_RS08305	COG0662	Cupin 2, conserved barrel domain protein
I6J17_RS08320	COG2194	sulfuric ester hydrolase activity
I6J17_RS08330	COG0489	protein tyrosine kinase activity
I6J17_RS08335	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J17_RS08345	COG0833	amino acid
I6J17_RS08350	COG0529	Catalyzes the synthesis of activated sulfate
I6J17_RS08355	COG2046	Belongs to the sulfate adenylyltransferase family
I6J17_RS08365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J17_RS08370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J17_RS08380	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6J17_RS08385	COG1122	ATPase activity
I6J17_RS08390	COG1122	ATPase activity
I6J17_RS08395	COG0203	ribosomal protein L17
I6J17_RS08400	COG0202	RNA polymerase activity
I6J17_RS08405	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J17_RS08410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J17_RS08415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J17_RS08420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J17_RS08425	COG0563	adenylate kinase activity
I6J17_RS08430	COG0201	protein transport
I6J17_RS08435	COG0200	Binds to the 23S rRNA
I6J17_RS08445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J17_RS08450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J17_RS08455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J17_RS08460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J17_RS08465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J17_RS08470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J17_RS08480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J17_RS08490	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J17_RS08495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J17_RS08500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J17_RS08510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J17_RS08515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J17_RS08535	COG0051	transcription antitermination factor activity, RNA binding
I6J17_RS08540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J17_RS08545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J17_RS08550	COG0049	tRNA binding
I6J17_RS08555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J17_RS08560	COG1358	cellular component organization or biogenesis
I6J17_RS08570	COG0085	RNA polymerase activity
I6J17_RS08575	COG2813	Specifically methylates the guanine in position
I6J17_RS08585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J17_RS08590	COG0081	regulation of translation
I6J17_RS08595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J17_RS08600	COG0250	Participates in transcription elongation, termination and antitermination
I6J17_RS08605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J17_RS08610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J17_RS08630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J17_RS08640	COG0215	cysteine-tRNA ligase activity
I6J17_RS08645	COG1045	serine acetyltransferase
I6J17_RS08650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J17_RS08655	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6J17_RS08665	COG4956	integral membrane protein (PIN domain superfamily)
I6J17_RS08670	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J17_RS08675	COG0542	response to heat
I6J17_RS08680	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I6J17_RS08685	COG3880	PFAM UvrB UvrC protein
I6J17_RS08730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J17_RS08735	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J17_RS08740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J17_RS08750	COG0590	tRNA wobble adenosine to inosine editing
I6J17_RS08765	COG1428	Deoxynucleoside kinase
I6J17_RS08770	COG1428	Deoxynucleoside kinase
I6J17_RS08780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J17_RS08785	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J17_RS08800	COG0517	IMP dehydrogenase activity
I6J17_RS08800	COG0516	GMP reductase activity
I6J17_RS08880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J17_RS08885	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J17_RS08890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J17_RS08895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J17_RS08900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J17_RS08905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J17_RS08910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J17_RS08915	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6J17_RS08920	COG0037	tRNA processing
I6J17_RS08925	COG0515	serine threonine protein kinase
I6J17_RS08930	COG2304	oxidoreductase activity
I6J17_RS08935	COG2208	phosphoserine phosphatase activity
I6J17_RS08945	COG1098	S1 RNA binding domain
I6J17_RS08965	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J17_RS08970	COG3956	TIGRFAM MazG family protein
I6J17_RS08975	COG2244	polysaccharide biosynthetic process
I6J17_RS08980	COG2002	toxin-antitoxin pair type II binding
I6J17_RS08985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J17_RS09000	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J17_RS09005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J17_RS09010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J17_RS09020	COG0251	oxidation-reduction process
I6J17_RS09025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J17_RS09030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J17_RS09040	COG4466	Protein conserved in bacteria
I6J17_RS09060	COG0084	hydrolase, TatD family'
I6J17_RS09070	COG2002	toxin-antitoxin pair type II binding
I6J17_RS09075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J17_RS09080	COG2827	Endonuclease containing a URI domain
I6J17_RS09085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6J17_RS09090	COG4467	Involved in initiation control of chromosome replication
I6J17_RS09095	COG1774	PSP1 C-terminal conserved region
I6J17_RS09100	COG0470	DNA polymerase III
I6J17_RS09105	COG1728	Protein conserved in bacteria
I6J17_RS09110	COG3870	Protein conserved in bacteria
I6J17_RS09120	COG1982	Orn Lys Arg decarboxylase major
I6J17_RS09155	COG3437	response regulator, receiver
I6J17_RS09160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J17_RS09165	COG0187	DNA topoisomerase II activity
I6J17_RS09175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J17_RS09180	COG2501	S4 domain
I6J17_RS09190	COG0592	DNA-directed DNA polymerase activity
I6J17_RS09195	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6J17_RS09200	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6J17_RS09205	COG0594	ribonuclease P activity
I6J17_RS09210	COG0706	membrane insertase activity
I6J17_RS09215	COG1847	R3H domain protein
I6J17_RS09220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J17_RS09225	COG0445	tRNA wobble uridine modification
I6J17_RS09230	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J17_RS09235	COG1475	DNA binding
I6J17_RS09245	COG1192	Involved in chromosome partitioning
I6J17_RS09250	COG1475	DNA binding
I6J17_RS09255	COG1811	Na channel or pump
I6J17_RS09265	COG0668	transmembrane transport
I6J17_RS09270	COG4481	Protein conserved in bacteria
I6J17_RS09275	COG0012	GTP binding
I6J17_RS09280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J17_RS09280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J17_RS09285	COG0307	riboflavin synthase, alpha
I6J17_RS09290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J17_RS09290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J17_RS09295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J17_RS09300	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J17_RS09310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J17_RS09320	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6J17_RS09325	COG0359	binds to the 23S rRNA
I6J17_RS09330	COG0305	Participates in initiation and elongation during chromosome replication
I6J17_RS09335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J17_RS09350	COG0745	RESPONSE REGULATOR receiver
I6J17_RS09355	COG5002	protein histidine kinase activity
I6J17_RS09360	COG4863	YycH protein
I6J17_RS09365	COG4853	Protein conserved in bacteria
I6J17_RS09370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J17_RS09375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J17_RS09380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6J17_RS09460	COG0579	oxidoreductase
I6J17_RS09495	COG1126	abc transporter atp-binding protein
I6J17_RS09530	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_RS09550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6J17_RS09560	COG1132	(ABC) transporter
I6J17_RS09580	COG0584	glycerophosphoryl diester phosphodiesterase
I6J17_RS09600	COG3842	ATPase activity
I6J17_RS09620	COG0028	Belongs to the TPP enzyme family
I6J17_RS09630	COG2814	Major facilitator Superfamily
I6J17_RS09645	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J17_RS09650	COG1442	glycosyl transferase family 8
I6J17_RS09655	COG0534	Mate efflux family protein
I6J17_RS09670	COG1119	ATPase activity
I6J17_RS09675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J17_RS09680	COG2011	ABC-type metal ion transport system permease component
I6J17_RS09685	COG1464	Belongs to the NlpA lipoprotein family
I6J17_RS09690	COG1966	Carbon starvation protein
I6J17_RS09695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J17_RS09700	COG2966	Psort location CytoplasmicMembrane, score
I6J17_RS09775	COG0367	asparagine synthase
I6J17_RS09780	COG0583	DNA-binding transcription factor activity
I6J17_RS09785	COG1380	Effector of murein hydrolase LrgA
I6J17_RS09790	COG1346	cytolysis
I6J17_RS09800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J17_RS09815	COG3850	Histidine kinase
I6J17_RS09815	COG5002	protein histidine kinase activity
I6J17_RS09830	COG1737	Transcriptional regulator
I6J17_RS09835	COG1785	Belongs to the alkaline phosphatase family
I6J17_RS09840	COG0514	ATP-dependent DNA helicase (RecQ)
I6J17_RS09845	COG0561	phosphatase activity
I6J17_RS09860	COG0351	phosphomethylpyrimidine kinase
I6J17_RS09870	COG1473	amidohydrolase
I6J17_RS09880	COG4948	Mandelate Racemase Muconate Lactonizing
I6J17_RS09885	COG3949	Membrane
I6J17_RS09910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J17_RS09920	COG2363	Small membrane protein
I6J17_RS09950	COG3253	May function as heme-dependent peroxidase
I6J17_RS09955	COG0280	phosphate acetyltransferase
I6J17_RS09965	COG0095	Lipoate-protein ligase
I6J17_RS09975	COG1078	dGTPase activity
I6J17_RS09980	COG3465	dGTPase activity
I6J17_RS09990	COG1994	Peptidase M50
I6J17_RS10000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J17_RS10005	COG0010	Belongs to the arginase family
I6J17_RS10015	COG0018	arginyl-trna synthetase
I6J17_RS10020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J17_RS10025	COG0247	lactate metabolic process
I6J17_RS10025	COG2181	nitrate reductase activity
I6J17_RS10030	COG0183	Belongs to the thiolase family
I6J17_RS10035	COG1960	acyl-CoA dehydrogenase activity
I6J17_RS10040	COG1960	acyl-CoA dehydrogenase activity
I6J17_RS10045	COG1309	transcriptional regulator
I6J17_RS10060	COG3343	RNA polymerase activity
I6J17_RS10065	COG0504	CTP synthase activity
I6J17_RS10070	COG1725	Transcriptional regulator
I6J17_RS10075	COG1131	(ABC) transporter
I6J17_RS10100	COG2204	response regulator
I6J17_RS10105	COG0191	fructose-bisphosphate aldolase activity
I6J17_RS10110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J17_RS10115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J17_RS10120	COG1494	fructose-1,6-bisphosphatase
I6J17_RS10125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J17_RS10130	COG0254	rRNA binding
I6J17_RS10135	COG1435	thymidine kinase activity
I6J17_RS10145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J17_RS10160	COG0009	L-threonylcarbamoyladenylate synthase
I6J17_RS10165	COG1971	Probably functions as a manganese efflux pump
I6J17_RS10195	COG0840	transmembrane signaling receptor activity
I6J17_RS10200	COG0698	ribose 5-phosphate isomerase
I6J17_RS10205	COG4475	Protein of unknown function (DUF436)
I6J17_RS10215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J17_RS10220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J17_RS10230	COG0356	it plays a direct role in the translocation of protons across the membrane
I6J17_RS10235	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J17_RS10245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J17_RS10250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J17_RS10255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J17_RS10260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J17_RS10265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J17_RS10270	COG4836	Membrane
I6J17_RS10280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J17_RS10285	COG2385	sporulation resulting in formation of a cellular spore
I6J17_RS10290	COG0739	heme binding
I6J17_RS10295	COG1609	Transcriptional regulator
I6J17_RS10300	COG1077	Cell shape determining protein MreB Mrl
I6J17_RS10305	COG4786	Flagellar basal body rod
I6J17_RS10310	COG4786	Flagellar basal body rod
I6J17_RS10315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J17_RS10325	COG0629	single-stranded DNA binding
I6J17_RS10340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J17_RS10360	COG1253	flavin adenine dinucleotide binding
I6J17_RS10365	COG0789	Transcriptional regulator
I6J17_RS10370	COG1253	flavin adenine dinucleotide binding
I6J17_RS10380	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J17_RS10385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J17_RS10395	COG1554	hydrolase, family 65, central catalytic
I6J17_RS10400	COG5521	maltodextrose utilization protein MalA
I6J17_RS10405	COG3833	ABC-type maltose transport systems, permease component
I6J17_RS10410	COG1175	transmembrane transport
I6J17_RS10415	COG2182	Extracellular solute-binding protein
I6J17_RS10425	COG0366	Alpha amylase catalytic
I6J17_RS10430	COG1609	Transcriptional regulator
I6J17_RS10435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J17_RS10440	COG1280	lysine exporter protein (LysE YggA)
I6J17_RS10445	COG0513	Belongs to the DEAD box helicase family
I6J17_RS10460	COG0705	Rhomboid family
I6J17_RS10465	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J17_RS10470	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6J17_RS10475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J17_RS10480	COG0864	Transcriptional regulator
I6J17_RS10485	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6J17_RS10490	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_RS10495	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_RS10500	COG2172	sigma factor antagonist activity
I6J17_RS10505	COG2208	phosphoserine phosphatase activity
I6J17_RS10510	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_RS10515	COG2172	sigma factor antagonist activity
I6J17_RS10520	COG1191	sigma factor activity
I6J17_RS10525	COG2208	phosphoserine phosphatase activity
I6J17_RS10530	COG2183	response to ionizing radiation
I6J17_RS10540	COG3091	SprT-like family
I6J17_RS10625	COG0802	atpase or kinase
I6J17_RS10630	COG1214	PFAM Peptidase M22, glycoprotease
I6J17_RS10635	COG0456	acetyltransferase
I6J17_RS10640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J17_RS10645	COG0488	(ABC) transporter
I6J17_RS10650	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J17_RS10655	COG0805	protein transport
I6J17_RS10670	COG1266	CAAX protease self-immunity
I6J17_RS10675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J17_RS10680	COG0459	protein refolding
I6J17_RS10685	COG2246	polysaccharide biosynthetic process
I6J17_RS10690	COG0463	Glycosyl transferase, family 2
I6J17_RS10700	COG4948	Mandelate Racemase Muconate Lactonizing
I6J17_RS10705	COG1335	isochorismatase
I6J17_RS10710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J17_RS10715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J17_RS10720	COG0519	Catalyzes the synthesis of GMP from XMP
I6J17_RS10720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J17_RS10735	COG3620	sequence-specific DNA binding
I6J17_RS10765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J17_RS10770	COG1120	ATPase activity
I6J17_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS10800	COG2391	methyltransferase activity
I6J17_RS10805	COG0425	Belongs to the sulfur carrier protein TusA family
I6J17_RS10825	COG1279	arginine transmembrane transporter activity
I6J17_RS10830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J17_RS10840	COG0425	Belongs to the sulfur carrier protein TusA family
I6J17_RS10845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J17_RS10865	COG1131	(ABC) transporter
I6J17_RS10870	COG1994	Peptidase M50
I6J17_RS10875	COG0535	radical SAM domain protein
I6J17_RS10885	COG1959	2 iron, 2 sulfur cluster binding
I6J17_RS10890	COG2910	NAD(P)H-binding
I6J17_RS10895	COG3479	Phenolic acid decarboxylase
I6J17_RS10900	COG1695	Transcriptional regulator
I6J17_RS10905	COG1725	Transcriptional regulator
I6J17_RS10910	COG1131	(ABC) transporter
I6J17_RS10920	COG3328	transposase activity
I6J17_RS10955	COG0471	metal ion transport
I6J17_RS10995	COG2814	Major facilitator Superfamily
I6J17_RS11000	COG1132	(ABC) transporter
I6J17_RS11010	COG2252	PERMEase
I6J17_RS11015	COG3711	transcriptional antiterminator
I6J17_RS11025	COG1301	dicarboxylic acid transport
I6J17_RS11070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J17_RS11075	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6J17_RS11085	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J17_RS11090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J17_RS11095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J17_RS11105	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J17_RS11110	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J17_RS11115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J17_RS11120	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6J17_RS11125	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J17_RS11130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J17_RS11135	COG0138	bifunctional purine biosynthesis protein purh
I6J17_RS11140	COG0151	Belongs to the GarS family
I6J17_RS11155	COG1470	cell adhesion involved in biofilm formation
I6J17_RS11160	COG4496	protein, YerC YecD
I6J17_RS11165	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I6J17_RS11170	COG0210	DNA helicase
I6J17_RS11175	COG3344	reverse transcriptase
I6J17_RS11180	COG0210	DNA helicase
I6J17_RS11190	COG4851	CamS sex pheromone cAM373 precursor
I6J17_RS11195	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J17_RS11200	COG2224	Isocitrate lyase
I6J17_RS11205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J17_RS11210	COG0154	amidase activity
I6J17_RS11215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J17_RS11235	COG1597	lipid kinase activity
I6J17_RS11240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J17_RS11270	COG2963	transposase activity
I6J17_RS11400	COG1401	restriction endodeoxyribonuclease activity
I6J17_RS11470	COG1064	alcohol dehydrogenase
I6J17_RS11480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J17_RS11505	COG0326	Molecular chaperone. Has ATPase activity
I6J17_RS11510	COG1473	amidohydrolase
I6J17_RS11515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J17_RS11520	COG0765	amino acid transport
I6J17_RS11525	COG1126	abc transporter atp-binding protein
I6J17_RS11530	COG1764	response to oxidative stress
I6J17_RS11535	COG2814	Major facilitator Superfamily
I6J17_RS11540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J17_RS11545	COG1984	allophanate hydrolase subunit 2
I6J17_RS11550	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J17_RS11565	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6J17_RS11575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J17_RS11585	COG2390	Transcriptional regulator
I6J17_RS11595	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6J17_RS11600	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6J17_RS11610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J17_RS11620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J17_RS11625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J17_RS11630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J17_RS11640	COG0431	NADPH-dependent FMN reductase
I6J17_RS11645	COG5583	Uncharacterized small protein (DUF2292)
I6J17_RS11650	COG3153	acetyltransferase
I6J17_RS11650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J17_RS11685	COG0791	NLP P60 protein
I6J17_RS11685	COG1388	LysM domain
I6J17_RS11700	COG1132	(ABC) transporter
I6J17_RS11705	COG1132	(ABC) transporter
I6J17_RS11710	COG3876	Protein conserved in bacteria
I6J17_RS11720	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J17_RS11735	COG1278	Cold shock
I6J17_RS11740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J17_RS11765	COG2372	response to copper ion
I6J17_RS11765	COG1276	copper resistance
I6J17_RS11770	COG4549	nuclear export factor GLE1
I6J17_RS11790	COG1929	Belongs to the glycerate kinase type-1 family
I6J17_RS11805	COG1328	CTP reductase activity
I6J17_RS11820	COG1301	dicarboxylic acid transport
I6J17_RS11855	COG0582	viral genome integration into host DNA
I6J17_RS11860	COG3403	YqcI/YcgG family
I6J17_RS11875	COG2190	(PTS) system
I6J17_RS11880	COG0386	Belongs to the glutathione peroxidase family
I6J17_RS11885	COG1280	lysine exporter protein (LysE YggA)
I6J17_RS11910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J17_RS11915	COG1715	Restriction endonuclease
I6J17_RS11920	COG0494	nUDIX hydrolase
I6J17_RS11950	COG3588	fructose-bisphosphate aldolase
I6J17_RS11975	COG0833	amino acid
I6J17_RS11980	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6J17_RS12000	COG3829	transcription factor binding
I6J17_RS12005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J17_RS12040	COG1683	Conserved Protein
I6J17_RS12080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J17_RS12085	COG0210	DNA helicase
I6J17_RS12090	COG2233	PERMEase
I6J17_RS12095	COG0730	response to heat
I6J17_RS12100	COG1113	amino acid transport
I6J17_RS12105	COG0778	Nitroreductase
I6J17_RS12175	COG2376	Dihydroxyacetone kinase
I6J17_RS12180	COG1461	Dihydroxyacetone kinase
I6J17_RS12185	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6J17_RS12190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J17_RS12195	COG0531	amino acid
I6J17_RS12200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J17_RS12225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J17_RS12230	COG2814	Major facilitator Superfamily
I6J17_RS12245	COG0561	phosphatase activity
I6J17_RS12255	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6J17_RS12260	COG0371	Dehydrogenase
I6J17_RS12265	COG1349	DNA-binding transcription factor activity
I6J17_RS12270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J17_RS12270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J17_RS12270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J17_RS12275	COG0025	NhaP-type Na H and K H
I6J17_RS12280	COG0166	Belongs to the GPI family
I6J17_RS12285	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6J17_RS12290	COG1304	FMN binding
I6J17_RS12385	COG1518	maintenance of DNA repeat elements
I6J17_RS12390	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6J17_RS12400	COG3620	sequence-specific DNA binding
I6J17_RS12415	COG0737	Belongs to the 5'-nucleotidase family
I6J17_RS12420	COG1737	Transcriptional regulator
I6J17_RS12430	COG4086	secreted protein
I6J17_RS12450	COG2197	response regulator
I6J17_RS12465	COG0288	reversible hydration of carbon dioxide
I6J17_RS12470	COG2226	methyltransferase
I6J17_RS12475	COG1854	S-ribosylhomocysteine lyase activity
I6J17_RS12480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J17_RS12485	COG0626	cystathionine gamma-synthase activity
I6J17_RS12490	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J17_RS12495	COG2268	Band 7 protein
I6J17_RS12500	COG1077	Cell shape determining protein MreB Mrl
I6J17_RS12505	COG1607	acyl-coa hydrolase
I6J17_RS12510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J17_RS12520	COG3189	MarR family transcriptional regulator
I6J17_RS12535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6J17_RS12540	COG1360	Flagellar Motor Protein
I6J17_RS12550	COG0693	protein deglycase activity
I6J17_RS12555	COG0024	Methionine aminopeptidase
I6J17_RS12560	COG4840	Belongs to the UPF0435 family
I6J17_RS12565	COG1295	ribonuclease BN
I6J17_RS12570	COG0477	Major facilitator Superfamily
I6J17_RS12575	COG0387	Pfam Sodium calcium exchanger
I6J17_RS12595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6J17_RS12600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J17_RS12605	COG1846	Transcriptional regulator
I6J17_RS12630	COG1279	arginine transmembrane transporter activity
I6J17_RS12635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J17_RS12640	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I6J17_RS12660	COG2839	Protein conserved in bacteria
I6J17_RS12665	COG1823	symporter activity
I6J17_RS12680	COG3655	Transcriptional regulator
I6J17_RS12720	COG2132	Multicopper oxidase
I6J17_RS12725	COG0252	asparaginase activity
I6J17_RS12730	COG3275	phosphorelay sensor kinase activity
I6J17_RS12735	COG3279	Response regulator of the LytR AlgR family
I6J17_RS12740	COG2223	nitrite transmembrane transporter activity
I6J17_RS12745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J17_RS12750	COG0670	Belongs to the BI1 family
I6J17_RS12755	COG2124	cytochrome p450
I6J17_RS12765	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_RS12770	COG1114	Component of the transport system for branched-chain amino acids
I6J17_RS12775	COG0129	dihydroxy-acid dehydratase activity
I6J17_RS12780	COG0028	Belongs to the TPP enzyme family
I6J17_RS12785	COG0440	acetolactate synthase activity
I6J17_RS12790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J17_RS12795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J17_RS12805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J17_RS12810	COG0066	3-isopropylmalate dehydratase activity
I6J17_RS12815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J17_RS12830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J17_RS12835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J17_RS12840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J17_RS12845	COG0840	transmembrane signaling receptor activity
I6J17_RS12850	COG0058	SHG alpha-glucan phosphorylase activity
I6J17_RS12865	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J17_RS12865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J17_RS12870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J17_RS12875	COG0134	indole-3-glycerol-phosphate synthase activity
I6J17_RS12880	COG0133	tryptophan synthase activity
I6J17_RS12890	COG0159	tryptophan synthase activity
I6J17_RS12905	COG2137	regulation of response to DNA damage stimulus
I6J17_RS12920	COG1988	membrane-bound metal-dependent
I6J17_RS12925	COG1194	a g-specific adenine glycosylase
I6J17_RS12930	COG0493	'glutamate synthase
I6J17_RS12935	COG0069	glutamate synthase activity
I6J17_RS12935	COG0070	glutamate synthase
I6J17_RS12935	COG0067	glutamate synthase
I6J17_RS12940	COG0583	DNA-binding transcription factor activity
I6J17_RS12945	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS12960	COG3557	Belongs to the UPF0374 family
I6J17_RS12965	COG1132	(ABC) transporter
I6J17_RS13010	COG0579	oxidoreductase
I6J17_RS13040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J17_RS13045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J17_RS13045	COG1263	PTS System
I6J17_RS13050	COG1737	Transcriptional regulator
I6J17_RS13055	COG4129	membrane
I6J17_RS13065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J17_RS13080	COG0735	belongs to the Fur family
I6J17_RS13085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J17_RS13090	COG0583	DNA-binding transcription factor activity
I6J17_RS13095	COG0028	Belongs to the TPP enzyme family
I6J17_RS13100	COG3527	Alpha-acetolactate decarboxylase
I6J17_RS13210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J17_RS13235	COG1131	(ABC) transporter
I6J17_RS13250	COG0431	NADPH-dependent FMN reductase
I6J17_RS13255	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J17_RS13260	COG1882	Formate acetyltransferase
I6J17_RS13270	COG2116	formate transmembrane transporter activity
I6J17_RS13280	COG0765	amino acid transport
I6J17_RS13285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J17_RS13290	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I6J17_RS13300	COG2095	MarC family integral membrane protein
I6J17_RS13315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J17_RS13325	COG2766	serine protein kinase
I6J17_RS13330	COG2718	Belongs to the UPF0229 family
I6J17_RS13345	COG0306	phosphate transporter
I6J17_RS13350	COG1392	Phosphate transport regulator
I6J17_RS13375	COG3594	Acyltransferase
I6J17_RS13380	COG2719	SpoVR family
I6J17_RS13390	COG0598	Magnesium transport protein CorA
I6J17_RS13395	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J17_RS13400	COG0601	transmembrane transport
I6J17_RS13405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J17_RS13410	COG0444	Belongs to the ABC transporter superfamily
I6J17_RS13415	COG4166	transmembrane transport
I6J17_RS13420	COG0791	NLP P60 protein
I6J17_RS13425	COG4608	Belongs to the ABC transporter superfamily
I6J17_RS13440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J17_RS13455	COG3383	formate dehydrogenase (NAD+) activity
I6J17_RS13475	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6J17_RS13495	COG0126	phosphoglycerate kinase activity
I6J17_RS13505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6J17_RS13510	COG0148	phosphopyruvate hydratase activity
I6J17_RS13515	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J17_RS13525	COG0557	exoribonuclease II activity
I6J17_RS13530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J17_RS13595	COG0488	(ABC) transporter
I6J17_RS13620	COG0800	Aldolase
I6J17_RS13630	COG0246	Mannitol dehydrogenase
I6J17_RS13635	COG2721	sulfolactate sulfo-lyase activity
I6J17_RS13640	COG1904	glucuronate isomerase
I6J17_RS13645	COG2211	Major facilitator Superfamily
I6J17_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS13655	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I6J17_RS13665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J17_RS13680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J17_RS13685	COG1595	DNA-templated transcription, initiation
I6J17_RS13700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J17_RS13710	COG0671	phosphoesterase, PA-phosphatase related
I6J17_RS13715	COG0753	catalase activity
I6J17_RS13725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J17_RS13750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_RS13755	COG0772	Belongs to the SEDS family
I6J17_RS13760	COG5577	PFAM Coat F domain
I6J17_RS13775	COG1024	Enoyl-CoA hydratase
I6J17_RS13775	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J17_RS13780	COG0183	Belongs to the thiolase family
I6J17_RS13785	COG1960	acyl-CoA dehydrogenase activity
I6J17_RS13790	COG1393	Belongs to the ArsC family
I6J17_RS13795	COG0509	glycine decarboxylation via glycine cleavage system
I6J17_RS13800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_RS13810	COG0396	ATPase activity
I6J17_RS13815	COG0719	Fe-S assembly protein
I6J17_RS13820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J17_RS13825	COG0822	iron-sulfur transferase activity
I6J17_RS13830	COG0719	Fe-S assembly protein
I6J17_RS13835	COG0737	Belongs to the 5'-nucleotidase family
I6J17_RS13840	COG3377	Domain of unknown function (DUF1805)
I6J17_RS13850	COG0739	heme binding
I6J17_RS13855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J17_RS13860	COG4470	Protein conserved in bacteria
I6J17_RS13865	COG2445	Protein of unknown function DUF86
I6J17_RS13870	COG0647	UMP catabolic process
I6J17_RS13875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J17_RS13880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J17_RS13885	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6J17_RS13900	COG4837	Protein of unknown function (DUF1462)
I6J17_RS13905	COG0316	Belongs to the HesB IscA family
I6J17_RS13945	COG0726	polysaccharide deacetylase
I6J17_RS13960	COG0492	ferredoxin-NADP+ reductase activity
I6J17_RS13965	COG1252	NADH dehydrogenase
I6J17_RS13975	COG3584	3D domain protein
I6J17_RS13980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J17_RS13990	COG0697	spore germination
I6J17_RS14000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J17_RS14010	COG2050	protein possibly involved in aromatic compounds catabolism
I6J17_RS14015	COG2814	Major facilitator Superfamily
I6J17_RS14065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J17_RS14085	COG0656	L-ascorbic acid biosynthetic process
I6J17_RS14090	COG1902	pentaerythritol trinitrate reductase activity
I6J17_RS14100	COG1098	S1 RNA binding domain
I6J17_RS14110	COG2155	Conserved Protein
I6J17_RS14120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J17_RS14140	COG1012	belongs to the aldehyde dehydrogenase family
I6J17_RS14155	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I6J17_RS14160	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS14185	COG2190	(PTS) system
I6J17_RS14190	COG1525	nuclease
I6J17_RS14195	COG1937	Protein conserved in bacteria
I6J17_RS14200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J17_RS14210	COG0038	chloride channel
I6J17_RS14240	COG0726	polysaccharide deacetylase
I6J17_RS14255	COG1388	LysM domain
I6J17_RS14260	COG0745	RESPONSE REGULATOR receiver
I6J17_RS14265	COG5002	protein histidine kinase activity
I6J17_RS14295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J17_RS14315	COG1522	sequence-specific DNA binding
I6J17_RS14325	COG2608	mercury ion transmembrane transporter activity
I6J17_RS14330	COG2217	Heavy metal translocating P-type atpase
I6J17_RS14345	COG1285	pathogenesis
I6J17_RS14490	COG1575	Belongs to the MenA family. Type 1 subfamily
I6J17_RS14495	COG1169	isochorismate synthase
I6J17_RS14500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6J17_RS14505	COG0596	Alpha beta hydrolase
I6J17_RS14510	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6J17_RS14515	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_RS14520	COG4948	Mandelate Racemase Muconate Lactonizing
I6J17_RS14530	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J17_RS14540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J17_RS14545	COG0783	Belongs to the Dps family
I6J17_RS14560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J17_RS14565	COG1116	anion transmembrane transporter activity
I6J17_RS14570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J17_RS14580	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J17_RS14585	COG1506	peptidase
I6J17_RS14610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J17_RS14615	COG0367	asparagine synthase
I6J17_RS14620	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J17_RS14625	COG2267	carboxylic ester hydrolase activity
I6J17_RS14635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6J17_RS14645	COG2814	Major facilitator Superfamily
I6J17_RS14650	COG0495	leucyl-tRNA aminoacylation
I6J17_RS14665	COG2244	polysaccharide biosynthetic process
I6J17_RS14670	COG1349	DNA-binding transcription factor activity
I6J17_RS14675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J17_RS14705	COG0510	thiamine kinase activity
I6J17_RS14715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J17_RS14720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J17_RS14725	COG5584	Small secreted protein
I6J17_RS14730	COG5002	protein histidine kinase activity
I6J17_RS14730	COG0784	Response regulator, receiver
I6J17_RS14735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6J17_RS14740	COG2208	phosphoserine phosphatase activity
I6J17_RS14745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_RS14750	COG4848	Belongs to the UPF0354 family
I6J17_RS14755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J17_RS14765	COG1674	ftsk spoiiie
I6J17_RS14770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J17_RS14780	COG4980	gas vesicle protein
I6J17_RS14785	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6J17_RS14785	COG1605	Chorismate mutase
I6J17_RS14795	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6J17_RS14800	COG0517	IMP dehydrogenase activity
I6J17_RS14805	COG0454	-acetyltransferase
I6J17_RS14810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J17_RS14820	COG4149	molybdate abc transporter
I6J17_RS14825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J17_RS14830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J17_RS14845	COG0303	'Molybdopterin
I6J17_RS14850	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6J17_RS14855	COG0314	molybdopterin synthase activity
I6J17_RS14860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6J17_RS14865	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J17_RS14870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J17_RS14875	COG2427	Protein of unknown function (DUF1641)
I6J17_RS14880	COG3383	formate dehydrogenase (NAD+) activity
I6J17_RS14885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J17_RS14900	COG3829	transcription factor binding
I6J17_RS14900	COG3290	protein histidine kinase activity
I6J17_RS14905	COG1012	belongs to the aldehyde dehydrogenase family
I6J17_RS14910	COG0506	proline dehydrogenase activity
I6J17_RS14925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J17_RS14930	COG2203	Gaf domain
I6J17_RS14930	COG2199	diguanylate cyclase activity
I6J17_RS14935	COG1956	GAF domain-containing protein
I6J17_RS14940	COG1309	transcriptional regulator
I6J17_RS14945	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6J17_RS14950	COG1104	cysteine desulfurase activity
I6J17_RS14955	COG0301	tRNA thio-modification
I6J17_RS14965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J17_RS14970	COG0616	signal peptide processing
I6J17_RS14975	COG1714	RDD family
I6J17_RS14985	COG3874	Sporulation protein YtfJ
I6J17_RS14990	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6J17_RS14995	COG0827	DNA restriction-modification system
I6J17_RS15000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J17_RS15010	COG0589	response to stress
I6J17_RS15020	COG0006	proline dipeptidase activity
I6J17_RS15025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6J17_RS15030	COG4109	DRTGG domain
I6J17_RS15040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J17_RS15055	COG0587	DNA-directed DNA polymerase activity
I6J17_RS15060	COG0281	malic enzyme
I6J17_RS15065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J17_RS15070	COG0825	malonyl-CoA metabolic process
I6J17_RS15075	COG0205	6-phosphofructokinase activity
I6J17_RS15085	COG0628	permease
I6J17_RS15090	COG2707	UPF0756 membrane protein
I6J17_RS15095	COG0372	Belongs to the citrate synthase family
I6J17_RS15100	COG0538	isocitrate dehydrogenase activity
I6J17_RS15105	COG0039	L-malate dehydrogenase activity
I6J17_RS15115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J17_RS15115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J17_RS15120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J17_RS15125	COG1971	Probably functions as a manganese efflux pump
I6J17_RS15130	COG0237	dephospho-CoA kinase activity
I6J17_RS15135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J17_RS15145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J17_RS15150	COG3611	Membrane attachment protein
I6J17_RS15155	COG1484	DNA-dependent DNA replication
I6J17_RS15165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J17_RS15175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J17_RS15185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J17_RS15200	COG1363	Peptidase, m42
I6J17_RS15205	COG0431	NADPH-dependent FMN reductase
I6J17_RS15225	COG1695	Transcriptional regulator
I6J17_RS15260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J17_RS15265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J17_RS15270	COG0072	phenylalanine-tRNA ligase activity
I6J17_RS15270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J17_RS15290	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6J17_RS15295	COG1286	toxin biosynthetic process
I6J17_RS15300	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J17_RS15300	COG1796	DNA polymerase
I6J17_RS15305	COG1193	negative regulation of DNA recombination
I6J17_RS15310	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_RS15315	COG1309	transcriptional regulator
I6J17_RS15320	COG1024	Enoyl-CoA hydratase
I6J17_RS15325	COG2086	electron transfer activity
I6J17_RS15330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J17_RS15335	COG3118	belongs to the thioredoxin family
I6J17_RS15340	COG0322	excinuclease ABC activity
I6J17_RS15350	COG1719	4-vinyl reductase, 4VR
I6J17_RS15355	COG2009	succinate dehydrogenase
I6J17_RS15360	COG1053	succinate dehydrogenase
I6J17_RS15365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J17_RS15370	COG0824	Thioesterase
I6J17_RS15380	COG2197	response regulator
I6J17_RS15410	COG1846	Transcriptional regulator
I6J17_RS15420	COG5401	PFAM Sporulation and spore germination
I6J17_RS15425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J17_RS15430	COG0622	Phosphoesterase
I6J17_RS15450	COG0457	Tetratricopeptide repeat
I6J17_RS15450	COG1477	protein flavinylation
I6J17_RS15455	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J17_RS15465	COG1067	ATP-dependent peptidase activity
I6J17_RS15465	COG0470	DNA polymerase III
I6J17_RS15470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J17_RS15475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6J17_RS15490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J17_RS15495	COG0181	hydroxymethylbilane synthase activity
I6J17_RS15505	COG0113	porphobilinogen synthase activity
I6J17_RS15510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J17_RS15515	COG1388	LysM domain
I6J17_RS15515	COG1388	LysM domain
I6J17_RS15520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J17_RS15530	COG0525	valine-tRNA ligase activity
I6J17_RS15535	COG0285	dihydrofolate synthase activity
I6J17_RS15580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J17_RS15590	COG1459	type II secretion system
I6J17_RS15615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6J17_RS15625	COG2003	Belongs to the UPF0758 family
I6J17_RS15635	COG2003	Belongs to the UPF0758 family
I6J17_RS15640	COG1077	Cell shape determining protein MreB Mrl
I6J17_RS15645	COG1792	Involved in formation and maintenance of cell shape
I6J17_RS15655	COG0850	regulation of cytokinetic process
I6J17_RS15660	COG2894	cell division
I6J17_RS15670	COG1994	Peptidase M50
I6J17_RS15675	COG1530	ribonuclease E activity
I6J17_RS15680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J17_RS15685	COG2868	ribosomal protein
I6J17_RS15690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J17_RS15695	COG3290	protein histidine kinase activity
I6J17_RS15700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J17_RS15705	COG4492	Belongs to the UPF0735 family
I6J17_RS15710	COG0077	Prephenate dehydratase
I6J17_RS15715	COG1827	regulation of RNA biosynthetic process
I6J17_RS15720	COG1388	LysM domain
I6J17_RS15730	COG0217	transcriptional regulatory protein
I6J17_RS15735	COG0632	four-way junction helicase activity
I6J17_RS15750	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J17_RS15755	COG0343	queuine tRNA-ribosyltransferase activity
I6J17_RS15760	COG1862	Preprotein translocase
I6J17_RS15770	COG2323	membrane
I6J17_RS15775	COG2244	polysaccharide biosynthetic process
I6J17_RS15785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J17_RS15785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J17_RS15790	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6J17_RS15790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J17_RS15795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J17_RS15800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J17_RS15805	COG1490	D-aminoacyl-tRNA deacylase activity
I6J17_RS15810	COG1846	Transcriptional regulator
I6J17_RS15815	COG1566	PFAM secretion protein HlyD family protein
I6J17_RS15820	COG2814	Major facilitator Superfamily
I6J17_RS15825	COG3103	Sh3 type 3 domain protein
I6J17_RS15825	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J17_RS15825	COG4991	sh3 domain protein
I6J17_RS15835	COG0124	histidyl-tRNA synthetase
I6J17_RS15840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J17_RS15850	COG0385	Bile acid
I6J17_RS15855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J17_RS15860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J17_RS15870	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_RS15895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_RS15910	COG0785	Cytochrome C biogenesis protein
I6J17_RS15920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_RS15940	COG1937	Protein conserved in bacteria
I6J17_RS15945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J17_RS15950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J17_RS15950	COG0425	Belongs to the sulfur carrier protein TusA family
I6J17_RS15955	COG2210	Belongs to the sulfur carrier protein TusA family
I6J17_RS15960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J17_RS15960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J17_RS15965	COG0425	Belongs to the sulfur carrier protein TusA family
I6J17_RS15970	COG0730	response to heat
I6J17_RS15975	COG0697	spore germination
I6J17_RS15990	COG1959	2 iron, 2 sulfur cluster binding
I6J17_RS15995	COG1104	cysteine desulfurase activity
I6J17_RS16000	COG0482	sulfurtransferase activity
I6J17_RS16005	COG0457	Tetratricopeptide repeat
I6J17_RS16005	COG1477	protein flavinylation
I6J17_RS16010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J17_RS16035	COG0628	permease
I6J17_RS16040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J17_RS16045	COG4472	Bacterial protein of unknown function (DUF965)
I6J17_RS16050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J17_RS16055	COG3906	Belongs to the UPF0473 family
I6J17_RS16060	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J17_RS16065	COG4122	O-methyltransferase activity
I6J17_RS16070	COG0572	uridine kinase
I6J17_RS16075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J17_RS16090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J17_RS16105	COG0450	alkyl hydroperoxide reductase
I6J17_RS16110	COG3634	alkyl hydroperoxide reductase activity
I6J17_RS16120	COG1183	phosphatidylcholine synthase activity
I6J17_RS16170	COG1704	LemA family
I6J17_RS16180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_RS16190	COG0071	Belongs to the small heat shock protein (HSP20) family
I6J17_RS16195	COG2132	Multicopper oxidase
I6J17_RS16200	COG3835	regulator
I6J17_RS16205	COG0277	FAD linked oxidase domain protein
I6J17_RS16210	COG0247	lactate metabolic process
I6J17_RS16215	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6J17_RS16220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6J17_RS16230	COG1534	Rna-binding protein
I6J17_RS16235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J17_RS16240	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6J17_RS16245	COG0799	negative regulation of ribosome biogenesis
I6J17_RS16250	COG2226	methyltransferase
I6J17_RS16255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J17_RS16260	COG1596	polysaccharide export
I6J17_RS16260	COG1555	photosystem II stabilization
I6J17_RS16265	COG2131	deaminase
I6J17_RS16270	COG2333	competence protein COMEC
I6J17_RS16270	COG0658	competence protein
I6J17_RS16280	COG1466	dna polymerase III delta subunit
I6J17_RS16285	COG0268	Binds directly to 16S ribosomal RNA
I6J17_RS16290	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J17_RS16295	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J17_RS16300	COG0481	GTPase activity
I6J17_RS16305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J17_RS16315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J17_RS16320	COG0443	Heat shock 70 kDa protein
I6J17_RS16330	COG2264	protein methyltransferase activity
I6J17_RS16335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J17_RS16340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J17_RS16345	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J17_RS16350	COG1254	Belongs to the acylphosphatase family
I6J17_RS16360	COG1610	YqeY-like protein
I6J17_RS16375	COG1702	phosphate starvation-inducible protein PhoH
I6J17_RS16385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J17_RS16390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6J17_RS16395	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J17_RS16405	COG1381	Involved in DNA repair and RecF pathway recombination
I6J17_RS16415	COG0517	IMP dehydrogenase activity
I6J17_RS16425	COG0358	DNA primase activity