locus-tag	class	description
ESP47_RS00005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ESP47_RS00010	COG2226	methyltransferase
ESP47_RS00030	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ESP47_RS00080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ESP47_RS00085	COG1113	amino acid transport
ESP47_RS00090	COG2814	Major facilitator Superfamily
ESP47_RS00100	COG1033	growth of symbiont in host cell
ESP47_RS00100	COG2409	Drug exporters of the RND superfamily
ESP47_RS00110	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
ESP47_RS00125	COG1960	acyl-CoA dehydrogenase activity
ESP47_RS00145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ESP47_RS00150	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ESP47_RS00160	COG1609	Transcriptional regulator
ESP47_RS00175	COG2996	Protein conserved in bacteria
ESP47_RS00180	COG0346	lactoylglutathione lyase activity
ESP47_RS00185	COG1482	cell wall glycoprotein biosynthetic process
ESP47_RS00195	COG0477	Major facilitator Superfamily
ESP47_RS00200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ESP47_RS00210	COG2188	Transcriptional regulator
ESP47_RS00215	COG1388	LysM domain
ESP47_RS00215	COG0791	NLP P60 protein
ESP47_RS00225	COG0768	penicillin binding
ESP47_RS00230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ESP47_RS00235	COG1739	Uncharacterized protein family UPF0029
ESP47_RS00245	COG2197	response regulator
ESP47_RS00250	COG0531	amino acid
ESP47_RS00255	COG1307	EDD domain protein, DegV family
ESP47_RS00260	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ESP47_RS00265	COG1040	competence protein
ESP47_RS00275	COG2747	anti-sigma28 factor FlgM
ESP47_RS00285	COG4786	Flagellar basal body rod
ESP47_RS00285	COG1256	bacterial-type flagellum assembly
ESP47_RS00290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ESP47_RS00300	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ESP47_RS00320	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ESP47_RS00325	COG1285	pathogenesis
ESP47_RS00330	COG0647	UMP catabolic process
ESP47_RS00340	COG2271	Major facilitator Superfamily
ESP47_RS00345	COG1113	amino acid transport
ESP47_RS00355	COG1113	amino acid transport
ESP47_RS00360	COG1067	ATP-dependent peptidase activity
ESP47_RS00375	COG2094	Belongs to the DNA glycosylase MPG family
ESP47_RS00385	COG1334	flagellar protein FlaG
ESP47_RS00390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ESP47_RS00395	COG1516	flagellar protein fliS
ESP47_RS00420	COG0653	protein targeting
ESP47_RS00430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ESP47_RS00440	COG2884	Cell division ATP-binding protein ftsE
ESP47_RS00445	COG2177	Part of the ABC transporter FtsEX involved in
ESP47_RS00450	COG0739	heme binding
ESP47_RS00475	COG0460	homoserine dehydrogenase
ESP47_RS00485	COG0793	Belongs to the peptidase S41A family
ESP47_RS00485	COG3409	Peptidoglycan-binding domain 1 protein
ESP47_RS00500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ESP47_RS00505	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESP47_RS00510	COG4605	iron ion homeostasis
ESP47_RS00515	COG4604	ABC transporter, ATP-binding protein
ESP47_RS00520	COG4607	ABC-type enterochelin transport system periplasmic component
ESP47_RS00535	COG0745	RESPONSE REGULATOR receiver
ESP47_RS00540	COG5002	protein histidine kinase activity
ESP47_RS00545	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ESP47_RS00555	COG0573	inorganic phosphate transmembrane transporter activity
ESP47_RS00560	COG0581	inorganic phosphate transmembrane transporter activity
ESP47_RS00570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ESP47_RS00575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ESP47_RS00625	COG0556	nucleotide-excision repair
ESP47_RS00630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ESP47_RS00635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ESP47_RS00645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ESP47_RS00650	COG1682	transport, permease protein
ESP47_RS00655	COG0463	Glycosyl transferase, family 2
ESP47_RS00655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ESP47_RS00660	COG3595	metallopeptidase activity
ESP47_RS00670	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ESP47_RS00675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ESP47_RS00680	COG0546	phosphoglycolate phosphatase activity
ESP47_RS00685	COG0110	maltose O-acetyltransferase activity
ESP47_RS00690	COG0457	Tetratricopeptide repeat
ESP47_RS00695	COG0492	ferredoxin-NADP+ reductase activity
ESP47_RS00700	COG1051	belongs to the nudix hydrolase family
ESP47_RS00705	COG1660	Displays ATPase and GTPase activities
ESP47_RS00710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ESP47_RS00715	COG1481	regulation of sporulation
ESP47_RS00720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_RS00755	COG3842	ATPase activity
ESP47_RS00760	COG2508	Transcriptional regulator
ESP47_RS00770	COG0189	ligase activity
ESP47_RS00775	COG0189	ligase activity
ESP47_RS00790	COG4399	Belongs to the UPF0754 family
ESP47_RS00800	COG0561	phosphatase activity
ESP47_RS00805	COG1024	Enoyl-CoA hydratase
ESP47_RS00815	COG0861	Integral membrane protein TerC family
ESP47_RS00820	COG0701	Predicted permease
ESP47_RS00825	COG3689	TIGRFAM TIGR03943 family protein
ESP47_RS00830	COG0420	3'-5' exonuclease activity
ESP47_RS00840	COG3481	metal-dependent phosphohydrolase, HD sub domain
ESP47_RS00850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ESP47_RS00865	COG1846	Transcriptional regulator
ESP47_RS00885	COG0537	adenosine 5'-monophosphoramidase activity
ESP47_RS00890	COG1131	(ABC) transporter
ESP47_RS00895	COG4473	ABC transporter
ESP47_RS00900	COG1473	amidohydrolase
ESP47_RS00905	COG3069	C4-dicarboxylate transmembrane transporter activity
ESP47_RS00910	COG2329	Antibiotic biosynthesis monooxygenase
ESP47_RS00915	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ESP47_RS00920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ESP47_RS00925	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ESP47_RS00930	COG1309	transcriptional regulator
ESP47_RS00935	COG1511	domain protein
ESP47_RS00940	COG2190	(PTS) system
ESP47_RS00940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_RS00940	COG1263	PTS System
ESP47_RS00940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_RS00940	COG1263	PTS System
ESP47_RS00940	COG2190	(PTS) system
ESP47_RS00945	COG1349	DNA-binding transcription factor activity
ESP47_RS00950	COG3254	rhamnose metabolic process
ESP47_RS00955	COG2814	Major facilitator Superfamily
ESP47_RS00960	COG0697	spore germination
ESP47_RS00965	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS00970	COG1999	signal sequence binding
ESP47_RS00985	COG0095	Lipoate-protein ligase
ESP47_RS00990	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_RS00995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ESP47_RS01005	COG0501	Belongs to the peptidase M48B family
ESP47_RS01025	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ESP47_RS01030	COG1074	ATP-dependent DNA helicase activity
ESP47_RS01065	COG2311	Membrane
ESP47_RS01070	COG0179	Fumarylacetoacetate (FAA) hydrolase
ESP47_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS01090	COG1307	EDD domain protein, DegV family
ESP47_RS01100	COG0561	phosphatase activity
ESP47_RS01105	COG2151	metal-sulfur cluster biosynthetic enzyme
ESP47_RS01135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ESP47_RS01140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ESP47_RS01155	COG4608	Belongs to the ABC transporter superfamily
ESP47_RS01160	COG0601	transmembrane transport
ESP47_RS01170	COG0747	negative chemotaxis
ESP47_RS01185	COG0180	Tryptophanyl-tRNA synthetase
ESP47_RS01195	COG4166	transmembrane transport
ESP47_RS01200	COG0601	transmembrane transport
ESP47_RS01205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESP47_RS01210	COG0444	Belongs to the ABC transporter superfamily
ESP47_RS01215	COG4608	Belongs to the ABC transporter superfamily
ESP47_RS01220	COG1393	Belongs to the ArsC family
ESP47_RS01225	COG4862	establishment of competence for transformation
ESP47_RS01230	COG4469	Competence protein
ESP47_RS01235	COG1164	Oligoendopeptidase f
ESP47_RS01250	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ESP47_RS01255	COG2346	COG2346, Truncated hemoglobins
ESP47_RS01275	COG0741	lytic transglycosylase activity
ESP47_RS01290	COG2357	RelA SpoT domain protein
ESP47_RS01300	COG0564	pseudouridine synthase activity
ESP47_RS01310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ESP47_RS01315	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ESP47_RS01350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ESP47_RS01385	COG2153	protein acetylation
ESP47_RS01395	COG2382	esterase
ESP47_RS01420	COG1940	carbohydrate kinase activity
ESP47_RS01430	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS01435	COG4152	abc transporter atp-binding protein
ESP47_RS01440	COG1668	transmembrane transport
ESP47_RS01450	COG3579	cysteine-type endopeptidase activity
ESP47_RS01505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESP47_RS01510	COG3344	reverse transcriptase
ESP47_RS01515	COG2059	Chromate
ESP47_RS01520	COG2059	Chromate
ESP47_RS01525	COG1522	sequence-specific DNA binding
ESP47_RS01550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ESP47_RS01555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ESP47_RS01575	COG1609	Transcriptional regulator
ESP47_RS01585	COG1554	hydrolase, family 65, central catalytic
ESP47_RS01590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESP47_RS01635	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS01650	COG1959	2 iron, 2 sulfur cluster binding
ESP47_RS01660	COG0730	response to heat
ESP47_RS01665	COG0783	Belongs to the Dps family
ESP47_RS01670	COG0673	inositol 2-dehydrogenase activity
ESP47_RS01675	COG3852	Histidine kinase
ESP47_RS01680	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ESP47_RS01695	COG0861	Integral membrane protein TerC family
ESP47_RS01720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ESP47_RS01740	COG0542	response to heat
ESP47_RS01745	COG3949	Membrane
ESP47_RS01755	COG4873	Protein conserved in bacteria
ESP47_RS01770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_RS01785	COG2084	Dehydrogenase
ESP47_RS01790	COG0436	Aminotransferase
ESP47_RS01795	COG0835	chemotaxis
ESP47_RS01795	COG0784	Response regulator, receiver
ESP47_RS01805	COG2409	Drug exporters of the RND superfamily
ESP47_RS01805	COG1033	growth of symbiont in host cell
ESP47_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS01830	COG4703	Protein of unknown function (DUF1797)
ESP47_RS01835	COG0517	IMP dehydrogenase activity
ESP47_RS01840	COG0583	DNA-binding transcription factor activity
ESP47_RS01845	COG2171	N-acyltransferase activity
ESP47_RS01850	COG1473	amidohydrolase
ESP47_RS01860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ESP47_RS01905	COG1982	Orn Lys Arg decarboxylase major
ESP47_RS01910	COG4476	Belongs to the UPF0223 family
ESP47_RS01925	COG0483	inositol monophosphate 1-phosphatase activity
ESP47_RS01935	COG1217	gtp-binding protein TYPA
ESP47_RS01945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ESP47_RS01950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ESP47_RS01955	COG4838	Belongs to the UPF0358 family
ESP47_RS01960	COG0772	Belongs to the SEDS family
ESP47_RS01965	COG1612	heme a metabolic process
ESP47_RS01970	COG0109	protoheme IX farnesyltransferase activity
ESP47_RS01975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ESP47_RS01975	COG2010	Cytochrome c
ESP47_RS01990	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ESP47_RS01995	COG3336	cytochrome c oxidase
ESP47_RS02005	COG2340	Cysteine-rich secretory protein family
ESP47_RS02010	COG2050	protein possibly involved in aromatic compounds catabolism
ESP47_RS02030	COG3679	Belongs to the UPF0342 family
ESP47_RS02035	COG4471	UPF0298 protein
ESP47_RS02050	COG0742	ribosomal rna small subunit methyltransferase
ESP47_RS02055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ESP47_RS02060	COG3314	Sporulation integral membrane protein YlbJ
ESP47_RS02065	COG1752	Esterase of the alpha-beta hydrolase superfamily
ESP47_RS02070	COG3480	Lon protease (S16) C-terminal proteolytic domain
ESP47_RS02075	COG1323	Belongs to the UPF0348 family
ESP47_RS02080	COG1399	metal-binding, possibly nucleic acid-binding protein
ESP47_RS02085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ESP47_RS02095	COG0454	-acetyltransferase
ESP47_RS02100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ESP47_RS02105	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ESP47_RS02110	COG2001	Belongs to the MraZ family
ESP47_RS02115	COG0275	rRNA processing
ESP47_RS02120	COG4839	cell division protein FtsL
ESP47_RS02125	COG0768	penicillin binding
ESP47_RS02130	COG0768	penicillin binding
ESP47_RS02145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ESP47_RS02150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ESP47_RS02155	COG0772	Belongs to the SEDS family
ESP47_RS02160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ESP47_RS02165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ESP47_RS02170	COG0849	cell division
ESP47_RS02175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ESP47_RS02190	COG1191	sigma factor activity
ESP47_RS02195	COG1191	sigma factor activity
ESP47_RS02200	COG1873	PFAM PRC-barrel domain
ESP47_RS02205	COG1388	LysM domain
ESP47_RS02205	COG3584	3D domain protein
ESP47_RS02215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ESP47_RS02220	COG1799	cell septum assembly
ESP47_RS02225	COG0762	integral membrane protein
ESP47_RS02230	COG2302	S4 RNA-binding domain
ESP47_RS02235	COG3599	regulation of cell shape
ESP47_RS02250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ESP47_RS02255	COG0564	pseudouridine synthase activity
ESP47_RS02270	COG0540	Belongs to the ATCase OTCase family
ESP47_RS02275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ESP47_RS02295	COG0167	dihydroorotate dehydrogenase activity
ESP47_RS02300	COG0284	orotidine-5'-phosphate decarboxylase activity
ESP47_RS02305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ESP47_RS02335	COG1917	Cupin 2, conserved barrel domain protein
ESP47_RS02335	COG2207	Transcriptional regulator
ESP47_RS02340	COG1070	Carbohydrate kinase
ESP47_RS02345	COG4806	L-rhamnose isomerase
ESP47_RS02350	COG0235	Class ii aldolase
ESP47_RS02355	COG1803	Methylglyoxal synthase
ESP47_RS02370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ESP47_RS02375	COG0477	Major facilitator Superfamily
ESP47_RS02380	COG0477	Major facilitator Superfamily
ESP47_RS02385	COG1309	transcriptional regulator
ESP47_RS02395	COG2076	Multidrug Resistance protein
ESP47_RS02410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_RS02425	COG0628	permease
ESP47_RS02430	COG0561	phosphatase activity
ESP47_RS02435	COG3573	Dehydrogenase
ESP47_RS02440	COG3573	Dehydrogenase
ESP47_RS02470	COG0720	synthase
ESP47_RS02480	COG0385	Bile acid
ESP47_RS02490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ESP47_RS02495	COG1561	YicC-like family, N-terminal region
ESP47_RS02500	COG2052	Domain of unknown function (DUF370)
ESP47_RS02505	COG0194	GDP metabolic process
ESP47_RS02510	COG1758	RNA polymerase activity
ESP47_RS02515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ESP47_RS02520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ESP47_RS02525	COG0242	peptide deformylase activity
ESP47_RS02530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ESP47_RS02535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ESP47_RS02535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ESP47_RS02540	COG0631	protein serine/threonine phosphatase activity
ESP47_RS02545	COG0515	serine threonine protein kinase
ESP47_RS02545	COG2815	serine threonine protein kinase
ESP47_RS02555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ESP47_RS02560	COG1564	THIamine pyrophosphokinase
ESP47_RS02570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ESP47_RS02575	COG1302	Protein conserved in bacteria
ESP47_RS02580	COG1461	Dihydroxyacetone kinase
ESP47_RS02585	COG1760	l-serine dehydratase
ESP47_RS02590	COG1760	l-serine dehydratase
ESP47_RS02595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ESP47_RS02600	COG1349	DNA-binding transcription factor activity
ESP47_RS02605	COG0416	fatty acid biosynthetic process
ESP47_RS02610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ESP47_RS02615	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS02625	COG0571	ribonuclease III activity
ESP47_RS02630	COG1196	nuclear chromosome segregation
ESP47_RS02635	COG0552	protein localization to endoplasmic reticulum
ESP47_RS02640	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ESP47_RS02645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ESP47_RS02655	COG1837	Belongs to the UPF0109 family
ESP47_RS02665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ESP47_RS02670	COG0336	Belongs to the RNA methyltransferase TrmD family
ESP47_RS02685	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ESP47_RS02700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ESP47_RS02705	COG0045	succinate-CoA ligase (ADP-forming) activity
ESP47_RS02710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ESP47_RS02715	COG0758	DNA mediated transformation
ESP47_RS02720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ESP47_RS02730	COG4974	Belongs to the 'phage' integrase family
ESP47_RS02735	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ESP47_RS02745	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ESP47_RS02750	COG1815	bacterial-type flagellum-dependent cell motility
ESP47_RS02755	COG1558	bacterial-type flagellum-dependent cell motility
ESP47_RS02760	COG1677	Flagellar hook-basal body complex protein FliE
ESP47_RS02765	COG1766	The M ring may be actively involved in energy transduction
ESP47_RS02770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ESP47_RS02780	COG1317	bacterial-type flagellum organization
ESP47_RS02785	COG1157	protein secretion by the type III secretion system
ESP47_RS02790	COG2882	bacterial-type flagellum organization
ESP47_RS02805	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ESP47_RS02815	COG4786	Flagellar basal body rod
ESP47_RS02825	COG1580	Controls the rotational direction of flagella during chemotaxis
ESP47_RS02830	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ESP47_RS02835	COG1776	CheC inhibitor of MCP methylation
ESP47_RS02835	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ESP47_RS02840	COG2201	protein-glutamate methylesterase activity
ESP47_RS02845	COG3190	flagellar
ESP47_RS02850	COG1338	Plays a role in the flagellum-specific transport system
ESP47_RS02855	COG1987	bacterial-type flagellum assembly
ESP47_RS02860	COG1684	flagellar biosynthetic protein fliR
ESP47_RS02865	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ESP47_RS02870	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ESP47_RS02875	COG1419	protein localization to endoplasmic reticulum
ESP47_RS02880	COG0455	bacterial-type flagellum organization
ESP47_RS02885	COG2201	protein-glutamate methylesterase activity
ESP47_RS02890	COG0643	Histidine kinase
ESP47_RS02890	COG2198	Histidine kinase
ESP47_RS02895	COG0835	chemotaxis
ESP47_RS02900	COG1776	CheC inhibitor of MCP methylation
ESP47_RS02905	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ESP47_RS02910	COG1191	sigma factor activity
ESP47_RS02920	COG0052	Belongs to the universal ribosomal protein uS2 family
ESP47_RS02925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ESP47_RS02930	COG0528	UMP kinase activity
ESP47_RS02935	COG0233	cytoplasmic translational termination
ESP47_RS02945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ESP47_RS02950	COG4589	Belongs to the CDS family
ESP47_RS02960	COG0750	zinc metalloprotease
ESP47_RS02965	COG0442	prolyl-tRNA aminoacylation
ESP47_RS02970	COG2176	DNA-directed DNA polymerase activity
ESP47_RS02975	COG0779	Required for maturation of 30S ribosomal subunits
ESP47_RS02980	COG0195	Participates in both transcription termination and antitermination
ESP47_RS02985	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ESP47_RS02990	COG1358	cellular component organization or biogenesis
ESP47_RS03000	COG1550	Protein conserved in bacteria
ESP47_RS03005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ESP47_RS03010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ESP47_RS03015	COG0196	riboflavin kinase activity
ESP47_RS03020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ESP47_RS03025	COG1185	polyribonucleotide nucleotidyltransferase activity
ESP47_RS03030	COG0726	polysaccharide deacetylase
ESP47_RS03035	COG0612	Peptidase, M16
ESP47_RS03040	COG1873	PFAM PRC-barrel domain
ESP47_RS03045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ESP47_RS03050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ESP47_RS03055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ESP47_RS03065	COG0527	aspartate kinase activity
ESP47_RS03075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ESP47_RS03080	COG0740	serine-type endopeptidase activity
ESP47_RS03090	COG4980	gas vesicle protein
ESP47_RS03090	COG1674	ftsk spoiiie
ESP47_RS03095	COG1744	ABC transporter substrate-binding protein PnrA-like
ESP47_RS03100	COG3845	ABC transporter
ESP47_RS03105	COG4603	Belongs to the binding-protein-dependent transport system permease family
ESP47_RS03110	COG1079	Belongs to the binding-protein-dependent transport system permease family
ESP47_RS03115	COG0612	Peptidase, M16
ESP47_RS03120	COG0612	Peptidase, M16
ESP47_RS03125	COG0300	oxidoreductase activity
ESP47_RS03140	COG1426	Protein conserved in bacteria
ESP47_RS03145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ESP47_RS03150	COG1546	Belongs to the CinA family
ESP47_RS03150	COG1058	Belongs to the CinA family
ESP47_RS03160	COG1418	mRNA catabolic process
ESP47_RS03165	COG1692	metallophosphoesterase
ESP47_RS03170	COG2359	stage V sporulation protein S
ESP47_RS03175	COG0826	peptidase U32
ESP47_RS03180	COG0826	peptidase U32
ESP47_RS03185	COG0531	amino acid
ESP47_RS03190	COG3829	transcription factor binding
ESP47_RS03195	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS03205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ESP47_RS03210	COG4550	Control of competence regulator ComK, YlbF/YmcA
ESP47_RS03220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ESP47_RS03225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ESP47_RS03250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ESP47_RS03265	COG0464	growth
ESP47_RS03275	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ESP47_RS03280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ESP47_RS03300	COG1321	iron dependent repressor
ESP47_RS03310	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ESP47_RS03320	COG1418	mRNA catabolic process
ESP47_RS03325	COG0488	(ABC) transporter
ESP47_RS03330	COG1413	lyase activity
ESP47_RS03345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ESP47_RS03350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ESP47_RS03355	COG1272	protein, Hemolysin III
ESP47_RS03360	COG2755	lipolytic protein G-D-S-L family
ESP47_RS03375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ESP47_RS03380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ESP47_RS03390	COG0840	transmembrane signaling receptor activity
ESP47_RS03395	COG4479	Belongs to the UPF0346 family
ESP47_RS03415	COG1876	peptidase activity
ESP47_RS03420	COG0793	Belongs to the peptidase S41A family
ESP47_RS03420	COG3409	Peptidoglycan-binding domain 1 protein
ESP47_RS03425	COG1846	Transcriptional regulator
ESP47_RS03430	COG2340	Cysteine-rich secretory protein family
ESP47_RS03435	COG0534	Mate efflux family protein
ESP47_RS03450	COG3285	dna ligase
ESP47_RS03450	COG1793	dna ligase
ESP47_RS03455	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ESP47_RS03460	COG0671	phosphoesterase, PA-phosphatase related
ESP47_RS03465	COG1368	sulfuric ester hydrolase activity
ESP47_RS03470	COG1331	Highly conserved protein containing a thioredoxin domain
ESP47_RS03475	COG2814	Major facilitator Superfamily
ESP47_RS03485	COG0745	RESPONSE REGULATOR receiver
ESP47_RS03490	COG5002	protein histidine kinase activity
ESP47_RS03500	COG0567	Dehydrogenase, E1 component
ESP47_RS03505	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESP47_RS03510	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS03540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ESP47_RS03550	COG1054	Belongs to the UPF0176 family
ESP47_RS03555	COG2135	peptidase activity
ESP47_RS03565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESP47_RS03570	COG0516	GMP reductase activity
ESP47_RS03570	COG0517	IMP dehydrogenase activity
ESP47_RS03575	COG0723	plastoquinol--plastocyanin reductase activity
ESP47_RS03575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ESP47_RS03580	COG3584	3D domain protein
ESP47_RS03580	COG1388	LysM domain
ESP47_RS03585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ESP47_RS03590	COG1113	amino acid transport
ESP47_RS03595	COG1280	lysine exporter protein (LysE YggA)
ESP47_RS03600	COG0598	Magnesium transport protein CorA
ESP47_RS03615	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ESP47_RS03620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ESP47_RS03625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ESP47_RS03630	COG0131	Imidazoleglycerol-phosphate dehydratase
ESP47_RS03635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ESP47_RS03645	COG0107	imidazoleglycerol-phosphate synthase activity
ESP47_RS03650	COG0140	phosphoribosyl-ATP diphosphatase activity
ESP47_RS03650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ESP47_RS03660	COG2391	methyltransferase activity
ESP47_RS03665	COG2962	Rard protein
ESP47_RS03670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ESP47_RS03675	COG0569	domain protein
ESP47_RS03695	COG2807	transmembrane transport
ESP47_RS03700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ESP47_RS03710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ESP47_RS03720	COG1278	Cold shock
ESP47_RS03725	COG0302	gtp cyclohydrolase
ESP47_RS03730	COG3634	alkyl hydroperoxide reductase activity
ESP47_RS03745	COG0577	efflux transmembrane transporter activity
ESP47_RS03750	COG1136	(ABC) transporter
ESP47_RS03755	COG0642	Histidine kinase
ESP47_RS03760	COG0745	RESPONSE REGULATOR receiver
ESP47_RS03780	COG3328	transposase activity
ESP47_RS03790	COG0640	Transcriptional regulator
ESP47_RS03795	COG2814	Major facilitator Superfamily
ESP47_RS03800	COG5039	Polysaccharide pyruvyl transferase
ESP47_RS03805	COG1113	amino acid transport
ESP47_RS03820	COG0477	Major facilitator Superfamily
ESP47_RS03830	COG1132	(ABC) transporter
ESP47_RS03835	COG1132	(ABC) transporter
ESP47_RS03845	COG1380	Effector of murein hydrolase LrgA
ESP47_RS03850	COG1346	cytolysis
ESP47_RS03855	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_RS03880	COG2309	aminopeptidase activity
ESP47_RS03890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ESP47_RS03910	COG0824	Thioesterase
ESP47_RS03920	COG4841	protein insertion into membrane
ESP47_RS03925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ESP47_RS03935	COG1832	CoA-binding protein
ESP47_RS03940	COG0187	DNA topoisomerase II activity
ESP47_RS03945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ESP47_RS03965	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ESP47_RS03970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ESP47_RS03970	COG0574	Belongs to the PEP-utilizing enzyme family
ESP47_RS03990	COG2070	2-Nitropropane dioxygenase
ESP47_RS04000	COG0681	Belongs to the peptidase S26 family
ESP47_RS04015	COG2226	methyltransferase
ESP47_RS04040	COG0456	acetyltransferase
ESP47_RS04045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ESP47_RS04050	COG0456	acetyltransferase
ESP47_RS04055	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS04060	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ESP47_RS04065	COG0351	phosphomethylpyrimidine kinase
ESP47_RS04070	COG0352	thiamine-phosphate diphosphorylase activity
ESP47_RS04075	COG2258	MOSC domain
ESP47_RS04110	COG1309	transcriptional regulator
ESP47_RS04115	COG2814	Major facilitator Superfamily
ESP47_RS04120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_RS04125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESP47_RS04135	COG1809	phosphosulfolactate synthase activity
ESP47_RS04140	COG2045	Belongs to the ComB family
ESP47_RS04145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ESP47_RS04150	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ESP47_RS04160	COG0789	Transcriptional regulator
ESP47_RS04165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ESP47_RS04170	COG0697	spore germination
ESP47_RS04175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ESP47_RS04180	COG0022	dehydrogenase e1 component
ESP47_RS04185	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESP47_RS04190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESP47_RS04195	COG3284	Transcriptional regulator
ESP47_RS04200	COG3264	Mechanosensitive ion channel
ESP47_RS04200	COG1511	domain protein
ESP47_RS04215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP47_RS04220	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ESP47_RS04235	COG0183	Belongs to the thiolase family
ESP47_RS04240	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_RS04260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ESP47_RS04265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ESP47_RS04270	COG2508	Transcriptional regulator
ESP47_RS04275	COG2233	PERMEase
ESP47_RS04285	COG2072	flavoprotein involved in K transport
ESP47_RS04295	COG0561	phosphatase activity
ESP47_RS04300	COG2322	membrane
ESP47_RS04315	COG0039	L-malate dehydrogenase activity
ESP47_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS04325	COG2223	nitrite transmembrane transporter activity
ESP47_RS04330	COG3773	Cell wall hydrolase
ESP47_RS04335	COG0708	Exodeoxyribonuclease III
ESP47_RS04345	COG0297	glycogen (starch) synthase activity
ESP47_RS04350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ESP47_RS04355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ESP47_RS04360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ESP47_RS04380	COG1247	-acetyltransferase
ESP47_RS04385	COG0494	nUDIX hydrolase
ESP47_RS04390	COG1914	H( )-stimulated, divalent metal cation uptake system
ESP47_RS04395	COG0783	Belongs to the Dps family
ESP47_RS04405	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ESP47_RS04410	COG1131	(ABC) transporter
ESP47_RS04435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ESP47_RS04445	COG2030	dehydratase
ESP47_RS04450	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS04465	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
ESP47_RS04470	COG0709	Synthesizes selenophosphate from selenide and ATP
ESP47_RS04480	COG0701	Predicted permease
ESP47_RS04485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ESP47_RS04490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ESP47_RS04500	COG1252	NADH dehydrogenase
ESP47_RS04505	COG2404	hydrolase activity, acting on ester bonds
ESP47_RS04515	COG4990	cell redox homeostasis
ESP47_RS04520	COG0789	Transcriptional regulator
ESP47_RS04545	COG0436	Aminotransferase
ESP47_RS04550	COG0165	Argininosuccinate lyase
ESP47_RS04555	COG0137	argininosuccinate synthase activity
ESP47_RS04560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ESP47_RS04565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ESP47_RS04570	COG0505	Belongs to the CarA family
ESP47_RS04575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ESP47_RS04580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ESP47_RS04585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ESP47_RS04590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ESP47_RS04605	COG3546	catalase activity
ESP47_RS04625	COG1619	proteins homologs of microcin C7 resistance protein MccF
ESP47_RS04630	COG2027	D-alanyl-D-alanine carboxypeptidase
ESP47_RS04635	COG0204	Acyl-transferase
ESP47_RS04645	COG4846	Membrane protein involved in cytochrome C biogenesis
ESP47_RS04650	COG2201	protein-glutamate methylesterase activity
ESP47_RS04655	COG0785	Cytochrome C biogenesis protein
ESP47_RS04660	COG3763	UPF0154 protein
ESP47_RS04675	COG4224	UPF0291 protein
ESP47_RS04680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ESP47_RS04690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ESP47_RS04700	COG0791	NLP P60 protein
ESP47_RS04700	COG1388	LysM domain
ESP47_RS04745	COG3953	SLT domain
ESP47_RS04745	COG5280	Phage tail tape measure protein TP901
ESP47_RS04785	COG0740	serine-type endopeptidase activity
ESP47_RS04820	COG0582	viral genome integration into host DNA
ESP47_RS04825	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ESP47_RS04865	COG0629	single-stranded DNA binding
ESP47_RS04905	COG1396	sequence-specific DNA binding
ESP47_RS04915	COG2176	DNA-directed DNA polymerase activity
ESP47_RS04920	COG0556	nucleotide-excision repair
ESP47_RS04935	COG0582	viral genome integration into host DNA
ESP47_RS04940	COG0174	glutamine synthetase
ESP47_RS04945	COG0789	Transcriptional regulator
ESP47_RS04950	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ESP47_RS04965	COG2233	PERMEase
ESP47_RS04975	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ESP47_RS04980	COG0116	Belongs to the methyltransferase superfamily
ESP47_RS04995	COG4474	Belongs to the UPF0398 family
ESP47_RS05005	COG3359	exonuclease
ESP47_RS05010	COG1205	dead DEAH box helicase
ESP47_RS05010	COG1111	helicase
ESP47_RS05015	COG0071	Belongs to the small heat shock protein (HSP20) family
ESP47_RS05040	COG3331	DNA recombination
ESP47_RS05045	COG4499	WXG100 protein secretion system (Wss), protein YukC
ESP47_RS05045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ESP47_RS05050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ESP47_RS05055	COG3935	DnaD domain protein
ESP47_RS05065	COG3344	reverse transcriptase
ESP47_RS05070	COG0017	Asparaginyl-tRNA synthetase
ESP47_RS05085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ESP47_RS05085	COG1199	ATP-dependent helicase activity
ESP47_RS05090	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ESP47_RS05095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ESP47_RS05115	COG0438	transferase activity, transferring glycosyl groups
ESP47_RS05120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ESP47_RS05125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ESP47_RS05130	COG1694	Mazg nucleotide pyrophosphohydrolase
ESP47_RS05135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ESP47_RS05145	COG2738	Putative neutral zinc metallopeptidase
ESP47_RS05155	COG4347	Protein of unknown function (DUF1405)
ESP47_RS05165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ESP47_RS05180	COG5582	Belongs to the UPF0302 family
ESP47_RS05185	COG0457	Tetratricopeptide repeat
ESP47_RS05195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ESP47_RS05200	COG0287	Prephenate dehydrogenase
ESP47_RS05205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ESP47_RS05210	COG4401	Chorismate mutase type I
ESP47_RS05215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ESP47_RS05220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ESP47_RS05225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ESP47_RS05230	COG0105	UTP biosynthetic process
ESP47_RS05235	COG0142	geranyltranstransferase activity
ESP47_RS05240	COG2226	methyltransferase
ESP47_RS05245	COG0142	geranyltranstransferase activity
ESP47_RS05255	COG0776	regulation of translation
ESP47_RS05260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ESP47_RS05280	COG1160	GTP binding
ESP47_RS05295	COG0539	negative regulation of cytoplasmic translation
ESP47_RS05300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ESP47_RS05305	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ESP47_RS05310	COG2959	enzyme of heme biosynthesis
ESP47_RS05315	COG3409	Peptidoglycan-binding domain 1 protein
ESP47_RS05315	COG3773	Cell wall hydrolase
ESP47_RS05320	COG2339	peptidase activity
ESP47_RS05325	COG0492	ferredoxin-NADP+ reductase activity
ESP47_RS05330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ESP47_RS05340	COG1408	metallophosphoesterase
ESP47_RS05355	COG3546	catalase activity
ESP47_RS05370	COG1266	CAAX protease self-immunity
ESP47_RS05375	COG0514	ATP-dependent DNA helicase (RecQ)
ESP47_RS05385	COG1141	Ferredoxin
ESP47_RS05390	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ESP47_RS05395	COG0739	heme binding
ESP47_RS05395	COG1196	nuclear chromosome segregation
ESP47_RS05395	COG0741	lytic transglycosylase activity
ESP47_RS05400	COG5002	protein histidine kinase activity
ESP47_RS05405	COG0745	RESPONSE REGULATOR receiver
ESP47_RS05410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ESP47_RS05415	COG1333	cytochrome c biogenesis protein
ESP47_RS05420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESP47_RS05425	COG1187	pseudouridine synthase activity
ESP47_RS05430	COG0700	Nucleoside recognition
ESP47_RS05435	COG2715	membrane protein required for spore maturation
ESP47_RS05440	COG1686	Belongs to the peptidase S11 family
ESP47_RS05445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ESP47_RS05470	COG0697	spore germination
ESP47_RS05490	COG1191	sigma factor activity
ESP47_RS05505	COG1686	Belongs to the peptidase S11 family
ESP47_RS05510	COG4974	Belongs to the 'phage' integrase family
ESP47_RS05520	COG0735	belongs to the Fur family
ESP47_RS05525	COG1300	Membrane
ESP47_RS05530	COG1379	DNA repair
ESP47_RS05545	COG0667	Aldo Keto reductase
ESP47_RS05555	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ESP47_RS05560	COG3853	Toxic anion resistance protein (TelA)
ESP47_RS05565	COG1073	alpha beta
ESP47_RS05570	COG1388	LysM domain
ESP47_RS05570	COG3858	chitin binding
ESP47_RS05580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ESP47_RS05585	COG0300	oxidoreductase activity
ESP47_RS05590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ESP47_RS05600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ESP47_RS05605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ESP47_RS05615	COG2195	Cleaves the N-terminal amino acid of tripeptides
ESP47_RS05635	COG1376	ErfK ybiS ycfS ynhG family protein
ESP47_RS05645	COG1105	Belongs to the carbohydrate kinase PfkB family
ESP47_RS05655	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESP47_RS05660	COG0022	dehydrogenase e1 component
ESP47_RS05665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ESP47_RS05670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESP47_RS05690	COG0584	glycerophosphoryl diester phosphodiesterase
ESP47_RS05695	COG0745	RESPONSE REGULATOR receiver
ESP47_RS05705	COG0750	zinc metalloprotease
ESP47_RS05710	COG0497	DNA recombination
ESP47_RS05720	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ESP47_RS05725	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ESP47_RS05740	COG1570	exodeoxyribonuclease VII activity
ESP47_RS05755	COG1302	Protein conserved in bacteria
ESP47_RS05760	COG0439	Biotin carboxylase
ESP47_RS05765	COG0511	ligase activity, forming carbon-carbon bonds
ESP47_RS05805	COG3854	ATPases associated with a variety of cellular activities
ESP47_RS05810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ESP47_RS05815	COG0006	proline dipeptidase activity
ESP47_RS05820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ESP47_RS05830	COG3872	metal-dependent enzyme
ESP47_RS05840	COG1752	Esterase of the alpha-beta hydrolase superfamily
ESP47_RS05850	COG3327	negative regulation of DNA-templated transcription, initiation
ESP47_RS05855	COG0183	Belongs to the thiolase family
ESP47_RS05860	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESP47_RS05865	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS05870	COG1024	Enoyl-CoA hydratase
ESP47_RS05875	COG0492	ferredoxin-NADP+ reductase activity
ESP47_RS05880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP47_RS05885	COG0095	Lipoate-protein ligase
ESP47_RS05890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ESP47_RS05895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ESP47_RS05905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ESP47_RS05910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ESP47_RS05925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ESP47_RS05950	COG4537	Required for transformation and DNA binding
ESP47_RS05955	COG1459	type II secretion system
ESP47_RS05960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ESP47_RS05975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESP47_RS05985	COG1940	carbohydrate kinase activity
ESP47_RS05990	COG4483	Protein conserved in bacteria
ESP47_RS05995	COG0457	Tetratricopeptide repeat
ESP47_RS05995	COG0705	Rhomboid family
ESP47_RS06000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ESP47_RS06010	COG0768	penicillin binding
ESP47_RS06015	COG0477	Major facilitator Superfamily
ESP47_RS06020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ESP47_RS06035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ESP47_RS06040	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ESP47_RS06045	COG0735	belongs to the Fur family
ESP47_RS06050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ESP47_RS06055	COG1121	(ABC) transporter
ESP47_RS06065	COG0791	NLP P60 protein
ESP47_RS06065	COG3883	PFAM NLP P60 protein
ESP47_RS06070	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ESP47_RS06075	COG0513	Belongs to the DEAD box helicase family
ESP47_RS06085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ESP47_RS06090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ESP47_RS06095	COG2384	SAM-dependent methyltransferase
ESP47_RS06100	COG2010	Cytochrome c
ESP47_RS06110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ESP47_RS06115	COG0358	DNA primase activity
ESP47_RS06125	COG0517	IMP dehydrogenase activity
ESP47_RS06135	COG1381	Involved in DNA repair and RecF pathway recombination
ESP47_RS06150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ESP47_RS06155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ESP47_RS06160	COG1480	7TM receptor with intracellular HD hydrolase
ESP47_RS06165	COG1702	phosphate starvation-inducible protein PhoH
ESP47_RS06180	COG1610	YqeY-like protein
ESP47_RS06195	COG1283	sodium-dependent phosphate transmembrane transporter activity
ESP47_RS06200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ESP47_RS06205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ESP47_RS06210	COG2264	protein methyltransferase activity
ESP47_RS06220	COG0443	Heat shock 70 kDa protein
ESP47_RS06225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ESP47_RS06235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ESP47_RS06240	COG0481	GTPase activity
ESP47_RS06245	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESP47_RS06250	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ESP47_RS06255	COG0268	Binds directly to 16S ribosomal RNA
ESP47_RS06260	COG1466	dna polymerase III delta subunit
ESP47_RS06270	COG2333	competence protein COMEC
ESP47_RS06270	COG0658	competence protein
ESP47_RS06275	COG2131	deaminase
ESP47_RS06280	COG1596	polysaccharide export
ESP47_RS06280	COG1555	photosystem II stabilization
ESP47_RS06285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ESP47_RS06290	COG2226	methyltransferase
ESP47_RS06295	COG0799	negative regulation of ribosome biogenesis
ESP47_RS06300	COG1713	HD superfamily hydrolase involved in NAD metabolism
ESP47_RS06305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ESP47_RS06310	COG1534	Rna-binding protein
ESP47_RS06320	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ESP47_RS06325	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ESP47_RS06330	COG0247	lactate metabolic process
ESP47_RS06335	COG0277	FAD linked oxidase domain protein
ESP47_RS06340	COG3835	regulator
ESP47_RS06345	COG2132	Multicopper oxidase
ESP47_RS06350	COG0071	Belongs to the small heat shock protein (HSP20) family
ESP47_RS06360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESP47_RS06400	COG1183	phosphatidylcholine synthase activity
ESP47_RS06415	COG3634	alkyl hydroperoxide reductase activity
ESP47_RS06420	COG0450	alkyl hydroperoxide reductase
ESP47_RS06455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ESP47_RS06460	COG0572	uridine kinase
ESP47_RS06465	COG4122	O-methyltransferase activity
ESP47_RS06470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ESP47_RS06475	COG3906	Belongs to the UPF0473 family
ESP47_RS06480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ESP47_RS06485	COG4472	Bacterial protein of unknown function (DUF965)
ESP47_RS06490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ESP47_RS06495	COG0628	permease
ESP47_RS06525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ESP47_RS06535	COG0482	sulfurtransferase activity
ESP47_RS06540	COG1104	cysteine desulfurase activity
ESP47_RS06545	COG1959	2 iron, 2 sulfur cluster binding
ESP47_RS06565	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS06570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ESP47_RS06575	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ESP47_RS06580	COG0385	Bile acid
ESP47_RS06590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ESP47_RS06595	COG0124	histidyl-tRNA synthetase
ESP47_RS06600	COG4991	sh3 domain protein
ESP47_RS06600	COG3103	Sh3 type 3 domain protein
ESP47_RS06600	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESP47_RS06605	COG2814	Major facilitator Superfamily
ESP47_RS06610	COG1566	PFAM secretion protein HlyD family protein
ESP47_RS06615	COG1846	Transcriptional regulator
ESP47_RS06620	COG1490	D-aminoacyl-tRNA deacylase activity
ESP47_RS06625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ESP47_RS06630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ESP47_RS06635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ESP47_RS06635	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ESP47_RS06650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ESP47_RS06650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ESP47_RS06660	COG2244	polysaccharide biosynthetic process
ESP47_RS06665	COG2323	membrane
ESP47_RS06675	COG1862	Preprotein translocase
ESP47_RS06680	COG0343	queuine tRNA-ribosyltransferase activity
ESP47_RS06685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ESP47_RS06700	COG0632	four-way junction helicase activity
ESP47_RS06705	COG0217	transcriptional regulatory protein
ESP47_RS06715	COG1388	LysM domain
ESP47_RS06720	COG1827	regulation of RNA biosynthetic process
ESP47_RS06725	COG0077	Prephenate dehydratase
ESP47_RS06730	COG4492	Belongs to the UPF0735 family
ESP47_RS06735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ESP47_RS06740	COG3290	protein histidine kinase activity
ESP47_RS06745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ESP47_RS06750	COG2868	ribosomal protein
ESP47_RS06755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ESP47_RS06760	COG1530	ribonuclease E activity
ESP47_RS06765	COG1994	Peptidase M50
ESP47_RS06775	COG2894	cell division
ESP47_RS06780	COG0850	regulation of cytokinetic process
ESP47_RS06790	COG1792	Involved in formation and maintenance of cell shape
ESP47_RS06795	COG1077	Cell shape determining protein MreB Mrl
ESP47_RS06800	COG2003	Belongs to the UPF0758 family
ESP47_RS06810	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ESP47_RS06835	COG1459	type II secretion system
ESP47_RS06845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ESP47_RS06880	COG0285	dihydrofolate synthase activity
ESP47_RS06895	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ESP47_RS06900	COG1388	LysM domain
ESP47_RS06900	COG1388	LysM domain
ESP47_RS06905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ESP47_RS06910	COG0113	porphobilinogen synthase activity
ESP47_RS06920	COG0181	hydroxymethylbilane synthase activity
ESP47_RS06925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ESP47_RS06940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ESP47_RS06945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ESP47_RS06950	COG1067	ATP-dependent peptidase activity
ESP47_RS06950	COG0470	DNA polymerase III
ESP47_RS06960	COG0544	peptidyl-prolyl cis-trans isomerase activity
ESP47_RS06965	COG0457	Tetratricopeptide repeat
ESP47_RS06965	COG1477	protein flavinylation
ESP47_RS06995	COG0622	Phosphoesterase
ESP47_RS07000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ESP47_RS07005	COG5401	PFAM Sporulation and spore germination
ESP47_RS07015	COG5577	PFAM Coat F domain
ESP47_RS07020	COG1063	alcohol dehydrogenase
ESP47_RS07025	COG5577	PFAM Coat F domain
ESP47_RS07040	COG1846	Transcriptional regulator
ESP47_RS07070	COG2197	response regulator
ESP47_RS07075	COG0824	Thioesterase
ESP47_RS07080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ESP47_RS07085	COG1053	succinate dehydrogenase
ESP47_RS07090	COG2009	succinate dehydrogenase
ESP47_RS07095	COG1719	4-vinyl reductase, 4VR
ESP47_RS07105	COG0322	excinuclease ABC activity
ESP47_RS07110	COG3118	belongs to the thioredoxin family
ESP47_RS07125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ESP47_RS07130	COG2086	electron transfer activity
ESP47_RS07135	COG1024	Enoyl-CoA hydratase
ESP47_RS07140	COG1309	transcriptional regulator
ESP47_RS07145	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_RS07150	COG1193	negative regulation of DNA recombination
ESP47_RS07155	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ESP47_RS07155	COG1796	DNA polymerase
ESP47_RS07160	COG1286	toxin biosynthetic process
ESP47_RS07165	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ESP47_RS07175	COG0072	phenylalanine-tRNA ligase activity
ESP47_RS07175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ESP47_RS07180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ESP47_RS07185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESP47_RS07220	COG2329	Antibiotic biosynthesis monooxygenase
ESP47_RS07235	COG1695	Transcriptional regulator
ESP47_RS07255	COG0431	NADPH-dependent FMN reductase
ESP47_RS07285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ESP47_RS07295	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ESP47_RS07305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ESP47_RS07315	COG1484	DNA-dependent DNA replication
ESP47_RS07320	COG3611	Membrane attachment protein
ESP47_RS07325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ESP47_RS07330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ESP47_RS07335	COG0237	dephospho-CoA kinase activity
ESP47_RS07340	COG1971	Probably functions as a manganese efflux pump
ESP47_RS07345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ESP47_RS07350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ESP47_RS07350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ESP47_RS07355	COG0039	L-malate dehydrogenase activity
ESP47_RS07360	COG0538	isocitrate dehydrogenase activity
ESP47_RS07365	COG0372	Belongs to the citrate synthase family
ESP47_RS07370	COG2707	UPF0756 membrane protein
ESP47_RS07375	COG0628	permease
ESP47_RS07385	COG0205	6-phosphofructokinase activity
ESP47_RS07390	COG0825	malonyl-CoA metabolic process
ESP47_RS07395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ESP47_RS07400	COG0281	malic enzyme
ESP47_RS07405	COG0587	DNA-directed DNA polymerase activity
ESP47_RS07420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ESP47_RS07430	COG4109	DRTGG domain
ESP47_RS07435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ESP47_RS07440	COG0006	proline dipeptidase activity
ESP47_RS07450	COG0589	response to stress
ESP47_RS07460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ESP47_RS07465	COG0827	DNA restriction-modification system
ESP47_RS07470	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ESP47_RS07475	COG3874	Sporulation protein YtfJ
ESP47_RS07485	COG1714	RDD family
ESP47_RS07490	COG0616	signal peptide processing
ESP47_RS07495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESP47_RS07505	COG0301	tRNA thio-modification
ESP47_RS07510	COG1104	cysteine desulfurase activity
ESP47_RS07515	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ESP47_RS07520	COG1309	transcriptional regulator
ESP47_RS07525	COG1956	GAF domain-containing protein
ESP47_RS07530	COG2199	diguanylate cyclase activity
ESP47_RS07530	COG2203	Gaf domain
ESP47_RS07540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ESP47_RS07550	COG0506	proline dehydrogenase activity
ESP47_RS07555	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS07560	COG3290	protein histidine kinase activity
ESP47_RS07560	COG3829	transcription factor binding
ESP47_RS07575	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ESP47_RS07580	COG3383	formate dehydrogenase (NAD+) activity
ESP47_RS07585	COG2427	Protein of unknown function (DUF1641)
ESP47_RS07590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ESP47_RS07595	COG0315	cyclic pyranopterin monophosphate synthase activity
ESP47_RS07600	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ESP47_RS07605	COG0314	molybdopterin synthase activity
ESP47_RS07610	COG1763	Mo-molybdopterin cofactor biosynthetic process
ESP47_RS07615	COG0303	'Molybdopterin
ESP47_RS07630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ESP47_RS07635	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ESP47_RS07640	COG4149	molybdate abc transporter
ESP47_RS07650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESP47_RS07655	COG0454	-acetyltransferase
ESP47_RS07660	COG0517	IMP dehydrogenase activity
ESP47_RS07665	COG0123	including yeast histone deacetylase and acetoin utilization protein
ESP47_RS07675	COG1605	Chorismate mutase
ESP47_RS07675	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ESP47_RS07680	COG4980	gas vesicle protein
ESP47_RS07690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ESP47_RS07695	COG1674	ftsk spoiiie
ESP47_RS07705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ESP47_RS07710	COG4848	Belongs to the UPF0354 family
ESP47_RS07715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESP47_RS07720	COG2208	phosphoserine phosphatase activity
ESP47_RS07725	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ESP47_RS07730	COG5002	protein histidine kinase activity
ESP47_RS07730	COG0784	Response regulator, receiver
ESP47_RS07745	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ESP47_RS07750	COG1363	Peptidase, m42
ESP47_RS07755	COG5584	Small secreted protein
ESP47_RS07765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESP47_RS07770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ESP47_RS07780	COG0510	thiamine kinase activity
ESP47_RS07805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ESP47_RS07810	COG1349	DNA-binding transcription factor activity
ESP47_RS07815	COG2244	polysaccharide biosynthetic process
ESP47_RS07835	COG0495	leucyl-tRNA aminoacylation
ESP47_RS07840	COG2814	Major facilitator Superfamily
ESP47_RS07855	COG0275	rRNA processing
ESP47_RS07870	COG2267	carboxylic ester hydrolase activity
ESP47_RS07875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ESP47_RS07880	COG0367	asparagine synthase
ESP47_RS07885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ESP47_RS07890	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ESP47_RS07900	COG1506	peptidase
ESP47_RS07905	COG0655	NAD(P)H dehydrogenase (quinone) activity
ESP47_RS07915	COG1070	Carbohydrate kinase
ESP47_RS07920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESP47_RS07925	COG1116	anion transmembrane transporter activity
ESP47_RS07930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_RS07945	COG0783	Belongs to the Dps family
ESP47_RS07950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ESP47_RS07960	COG0803	Belongs to the bacterial solute-binding protein 9 family
ESP47_RS07970	COG4948	Mandelate Racemase Muconate Lactonizing
ESP47_RS07975	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_RS07980	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ESP47_RS07985	COG0596	Alpha beta hydrolase
ESP47_RS07990	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ESP47_RS07995	COG1169	isochorismate synthase
ESP47_RS08000	COG1575	Belongs to the MenA family. Type 1 subfamily
ESP47_RS08125	COG1285	pathogenesis
ESP47_RS08165	COG2217	Heavy metal translocating P-type atpase
ESP47_RS08170	COG2608	mercury ion transmembrane transporter activity
ESP47_RS08185	COG1522	sequence-specific DNA binding
ESP47_RS08205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ESP47_RS08225	COG0726	polysaccharide deacetylase
ESP47_RS08255	COG0038	chloride channel
ESP47_RS08265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ESP47_RS08270	COG1937	Protein conserved in bacteria
ESP47_RS08275	COG1525	nuclease
ESP47_RS08280	COG2190	(PTS) system
ESP47_RS08295	COG0235	Class ii aldolase
ESP47_RS08300	COG2160	L-arabinose isomerase activity
ESP47_RS08305	COG1609	Transcriptional regulator
ESP47_RS08310	COG4213	ABC transporter substrate-binding protein
ESP47_RS08320	COG4214	carbohydrate transport
ESP47_RS08325	COG2160	L-arabinose isomerase activity
ESP47_RS08335	COG1609	Transcriptional regulator
ESP47_RS08340	COG0840	transmembrane signaling receptor activity
ESP47_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS08360	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ESP47_RS08380	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS08400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ESP47_RS08410	COG2155	Conserved Protein
ESP47_RS08425	COG1098	S1 RNA binding domain
ESP47_RS08440	COG0656	L-ascorbic acid biosynthetic process
ESP47_RS08460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ESP47_RS08490	COG2814	Major facilitator Superfamily
ESP47_RS08495	COG2050	protein possibly involved in aromatic compounds catabolism
ESP47_RS08515	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ESP47_RS08525	COG0697	spore germination
ESP47_RS08535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ESP47_RS08540	COG3584	3D domain protein
ESP47_RS08550	COG1252	NADH dehydrogenase
ESP47_RS08555	COG0492	ferredoxin-NADP+ reductase activity
ESP47_RS08580	COG0316	Belongs to the HesB IscA family
ESP47_RS08585	COG4837	Protein of unknown function (DUF1462)
ESP47_RS08590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ESP47_RS08595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ESP47_RS08600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ESP47_RS08605	COG0647	UMP catabolic process
ESP47_RS08610	COG2445	Protein of unknown function DUF86
ESP47_RS08615	COG4470	Protein conserved in bacteria
ESP47_RS08620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ESP47_RS08625	COG0739	heme binding
ESP47_RS08635	COG3377	Domain of unknown function (DUF1805)
ESP47_RS08640	COG0737	Belongs to the 5'-nucleotidase family
ESP47_RS08645	COG0719	Fe-S assembly protein
ESP47_RS08650	COG0822	iron-sulfur transferase activity
ESP47_RS08655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ESP47_RS08660	COG0719	Fe-S assembly protein
ESP47_RS08665	COG0396	ATPase activity
ESP47_RS08680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESP47_RS08685	COG0509	glycine decarboxylation via glycine cleavage system
ESP47_RS08690	COG1393	Belongs to the ArsC family
ESP47_RS08695	COG1960	acyl-CoA dehydrogenase activity
ESP47_RS08700	COG0183	Belongs to the thiolase family
ESP47_RS08705	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESP47_RS08705	COG1024	Enoyl-CoA hydratase
ESP47_RS08720	COG5577	PFAM Coat F domain
ESP47_RS08725	COG0772	Belongs to the SEDS family
ESP47_RS08730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESP47_RS08745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ESP47_RS08750	COG2200	EAL domain
ESP47_RS08750	COG2202	Pas domain
ESP47_RS08750	COG2199	diguanylate cyclase activity
ESP47_RS08755	COG0753	catalase activity
ESP47_RS08760	COG0671	phosphoesterase, PA-phosphatase related
ESP47_RS08770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ESP47_RS08790	COG1595	DNA-templated transcription, initiation
ESP47_RS08795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ESP47_RS08810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ESP47_RS08820	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ESP47_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS08830	COG2211	Major facilitator Superfamily
ESP47_RS08835	COG1904	glucuronate isomerase
ESP47_RS08840	COG2721	sulfolactate sulfo-lyase activity
ESP47_RS08845	COG0246	Mannitol dehydrogenase
ESP47_RS08855	COG0800	Aldolase
ESP47_RS08860	COG1414	Transcriptional regulator
ESP47_RS08925	COG0557	exoribonuclease II activity
ESP47_RS08930	COG1647	Serine aminopeptidase, S33
ESP47_RS08935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ESP47_RS08950	COG0148	phosphopyruvate hydratase activity
ESP47_RS08955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ESP47_RS08965	COG0126	phosphoglycerate kinase activity
ESP47_RS08985	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ESP47_RS09000	COG3383	formate dehydrogenase (NAD+) activity
ESP47_RS09010	COG0840	transmembrane signaling receptor activity
ESP47_RS09040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ESP47_RS09055	COG4608	Belongs to the ABC transporter superfamily
ESP47_RS09060	COG0791	NLP P60 protein
ESP47_RS09065	COG4166	transmembrane transport
ESP47_RS09070	COG0444	Belongs to the ABC transporter superfamily
ESP47_RS09075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESP47_RS09080	COG0601	transmembrane transport
ESP47_RS09085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ESP47_RS09095	COG0598	Magnesium transport protein CorA
ESP47_RS09110	COG2719	SpoVR family
ESP47_RS09115	COG3594	Acyltransferase
ESP47_RS09140	COG1392	Phosphate transport regulator
ESP47_RS09145	COG0306	phosphate transporter
ESP47_RS09160	COG2718	Belongs to the UPF0229 family
ESP47_RS09165	COG2766	serine protein kinase
ESP47_RS09175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ESP47_RS09190	COG2095	MarC family integral membrane protein
ESP47_RS09200	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ESP47_RS09205	COG0596	Alpha beta hydrolase
ESP47_RS09210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_RS09215	COG0765	amino acid transport
ESP47_RS09220	COG1126	abc transporter atp-binding protein
ESP47_RS09225	COG2116	formate transmembrane transporter activity
ESP47_RS09245	COG1882	Formate acetyltransferase
ESP47_RS09250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ESP47_RS09255	COG0431	NADPH-dependent FMN reductase
ESP47_RS09270	COG1131	(ABC) transporter
ESP47_RS09310	COG0745	RESPONSE REGULATOR receiver
ESP47_RS09315	COG5002	protein histidine kinase activity
ESP47_RS09315	COG3850	Histidine kinase
ESP47_RS09325	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ESP47_RS09335	COG2188	Transcriptional regulator
ESP47_RS09340	COG3104	oligopeptide transport
ESP47_RS09345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ESP47_RS09350	COG1131	(ABC) transporter
ESP47_RS09355	COG4555	ABC transporter
ESP47_RS09375	COG1846	Transcriptional regulator
ESP47_RS09395	COG1136	(ABC) transporter
ESP47_RS09395	COG0577	efflux transmembrane transporter activity
ESP47_RS09425	COG2271	Major facilitator Superfamily
ESP47_RS09435	COG0697	spore germination
ESP47_RS09450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESP47_RS09560	COG3527	Alpha-acetolactate decarboxylase
ESP47_RS09565	COG0028	Belongs to the TPP enzyme family
ESP47_RS09570	COG0583	DNA-binding transcription factor activity
ESP47_RS09575	COG0735	belongs to the Fur family
ESP47_RS09590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ESP47_RS09595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESP47_RS09600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_RS09605	COG1116	anion transmembrane transporter activity
ESP47_RS09610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ESP47_RS09615	COG2814	Major facilitator Superfamily
ESP47_RS09635	COG1737	Transcriptional regulator
ESP47_RS09640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_RS09640	COG1263	PTS System
ESP47_RS09645	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ESP47_RS09655	COG1132	(ABC) transporter
ESP47_RS09660	COG3557	Belongs to the UPF0374 family
ESP47_RS09675	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS09680	COG0583	DNA-binding transcription factor activity
ESP47_RS09685	COG0070	glutamate synthase
ESP47_RS09685	COG0069	glutamate synthase activity
ESP47_RS09685	COG0067	glutamate synthase
ESP47_RS09690	COG0493	'glutamate synthase
ESP47_RS09710	COG1131	(ABC) transporter
ESP47_RS09720	COG1988	membrane-bound metal-dependent
ESP47_RS09725	COG1194	a g-specific adenine glycosylase
ESP47_RS09760	COG0159	tryptophan synthase activity
ESP47_RS09770	COG0133	tryptophan synthase activity
ESP47_RS09775	COG0134	indole-3-glycerol-phosphate synthase activity
ESP47_RS09780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ESP47_RS09785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ESP47_RS09785	COG0512	Glutamine amidotransferase of anthranilate synthase
ESP47_RS09795	COG0577	efflux transmembrane transporter activity
ESP47_RS09800	COG1136	(ABC) transporter
ESP47_RS09800	COG0577	efflux transmembrane transporter activity
ESP47_RS09805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ESP47_RS09825	COG1131	(ABC) transporter
ESP47_RS09860	COG2197	response regulator
ESP47_RS09865	COG4585	Histidine kinase
ESP47_RS09875	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS09875	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS09885	COG0058	SHG alpha-glucan phosphorylase activity
ESP47_RS09890	COG0840	transmembrane signaling receptor activity
ESP47_RS09895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ESP47_RS09900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ESP47_RS09905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ESP47_RS09920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ESP47_RS09925	COG0066	3-isopropylmalate dehydratase activity
ESP47_RS09930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ESP47_RS09940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ESP47_RS09945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ESP47_RS09950	COG0440	acetolactate synthase activity
ESP47_RS09955	COG0028	Belongs to the TPP enzyme family
ESP47_RS09960	COG0129	dihydroxy-acid dehydratase activity
ESP47_RS09970	COG1114	Component of the transport system for branched-chain amino acids
ESP47_RS09975	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_RS09985	COG2124	cytochrome p450
ESP47_RS09990	COG0670	Belongs to the BI1 family
ESP47_RS09995	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ESP47_RS10000	COG2223	nitrite transmembrane transporter activity
ESP47_RS10005	COG3279	Response regulator of the LytR AlgR family
ESP47_RS10010	COG3275	phosphorelay sensor kinase activity
ESP47_RS10015	COG0252	asparaginase activity
ESP47_RS10020	COG2132	Multicopper oxidase
ESP47_RS10025	COG1309	transcriptional regulator
ESP47_RS10030	COG1511	domain protein
ESP47_RS10060	COG0840	transmembrane signaling receptor activity
ESP47_RS10060	COG5278	phosphoserine phosphatase activity
ESP47_RS10065	COG3739	integral membrane protein
ESP47_RS10070	COG3655	Transcriptional regulator
ESP47_RS10085	COG1823	symporter activity
ESP47_RS10090	COG2839	Protein conserved in bacteria
ESP47_RS10110	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ESP47_RS10115	COG0477	Major facilitator Superfamily
ESP47_RS10120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ESP47_RS10125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ESP47_RS10130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ESP47_RS10135	COG0840	transmembrane signaling receptor activity
ESP47_RS10150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ESP47_RS10155	COG1132	(ABC) transporter
ESP47_RS10160	COG1846	Transcriptional regulator
ESP47_RS10170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ESP47_RS10175	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ESP47_RS10195	COG0387	Pfam Sodium calcium exchanger
ESP47_RS10200	COG0477	Major facilitator Superfamily
ESP47_RS10205	COG1295	ribonuclease BN
ESP47_RS10210	COG4840	Belongs to the UPF0435 family
ESP47_RS10215	COG0024	Methionine aminopeptidase
ESP47_RS10220	COG0693	protein deglycase activity
ESP47_RS10225	COG1360	Flagellar Motor Protein
ESP47_RS10230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ESP47_RS10240	COG3189	MarR family transcriptional regulator
ESP47_RS10250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ESP47_RS10255	COG1607	acyl-coa hydrolase
ESP47_RS10260	COG1077	Cell shape determining protein MreB Mrl
ESP47_RS10265	COG2268	Band 7 protein
ESP47_RS10270	COG1585	Membrane protein implicated in regulation of membrane protease activity
ESP47_RS10275	COG0626	cystathionine gamma-synthase activity
ESP47_RS10280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ESP47_RS10285	COG1854	S-ribosylhomocysteine lyase activity
ESP47_RS10290	COG2226	methyltransferase
ESP47_RS10295	COG0288	reversible hydration of carbon dioxide
ESP47_RS10300	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESP47_RS10310	COG2197	response regulator
ESP47_RS10330	COG4086	secreted protein
ESP47_RS10335	COG0737	Belongs to the 5'-nucleotidase family
ESP47_RS10350	COG3620	sequence-specific DNA binding
ESP47_RS10355	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ESP47_RS10360	COG1518	maintenance of DNA repeat elements
ESP47_RS10410	COG1304	FMN binding
ESP47_RS10420	COG0166	Belongs to the GPI family
ESP47_RS10425	COG0025	NhaP-type Na H and K H
ESP47_RS10430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ESP47_RS10430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_RS10430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ESP47_RS10435	COG1349	DNA-binding transcription factor activity
ESP47_RS10440	COG0371	Dehydrogenase
ESP47_RS10455	COG0561	phosphatase activity
ESP47_RS10470	COG2814	Major facilitator Superfamily
ESP47_RS10475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ESP47_RS10490	COG2357	RelA SpoT domain protein
ESP47_RS10495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ESP47_RS10500	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ESP47_RS10505	COG1461	Dihydroxyacetone kinase
ESP47_RS10510	COG2376	Dihydroxyacetone kinase
ESP47_RS10520	COG0778	Nitroreductase
ESP47_RS10525	COG1113	amino acid transport
ESP47_RS10530	COG0730	response to heat
ESP47_RS10535	COG2233	PERMEase
ESP47_RS10545	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ESP47_RS10570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ESP47_RS10575	COG1024	Enoyl-CoA hydratase
ESP47_RS10580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ESP47_RS10585	COG0511	ligase activity, forming carbon-carbon bonds
ESP47_RS10590	COG0439	Biotin carboxylase
ESP47_RS10595	COG1960	acyl-CoA dehydrogenase activity
ESP47_RS10600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESP47_RS10615	COG1349	DNA-binding transcription factor activity
ESP47_RS10625	COG2376	Dihydroxyacetone kinase
ESP47_RS10635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ESP47_RS10645	COG2271	Major facilitator Superfamily
ESP47_RS10655	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESP47_RS10665	COG0698	ribose 5-phosphate isomerase
ESP47_RS10670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ESP47_RS10675	COG1494	fructose-1,6-bisphosphatase
ESP47_RS10680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ESP47_RS10690	COG3829	transcription factor binding
ESP47_RS10695	COG0833	amino acid
ESP47_RS10735	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ESP47_RS10740	COG1140	nitrate reductase beta subunit
ESP47_RS10750	COG2181	nitrate reductase activity
ESP47_RS10755	COG2223	nitrite transmembrane transporter activity
ESP47_RS10760	COG3588	fructose-bisphosphate aldolase
ESP47_RS10780	COG4268	DNA restriction-modification system
ESP47_RS10785	COG1401	restriction endodeoxyribonuclease activity
ESP47_RS10790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ESP47_RS10860	COG0583	DNA-binding transcription factor activity
ESP47_RS10865	COG0431	NADPH-dependent FMN reductase
ESP47_RS10870	COG0454	-acetyltransferase
ESP47_RS10875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_RS10880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_RS10885	COG0765	amino acid transport
ESP47_RS10890	COG0765	amino acid transport
ESP47_RS10895	COG1126	abc transporter atp-binding protein
ESP47_RS10900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESP47_RS10905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ESP47_RS10910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESP47_RS10920	COG0386	Belongs to the glutathione peroxidase family
ESP47_RS10925	COG2190	(PTS) system
ESP47_RS10940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_RS10940	COG1263	PTS System
ESP47_RS10945	COG0517	IMP dehydrogenase activity
ESP47_RS10945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ESP47_RS10955	COG0281	malic enzyme
ESP47_RS10970	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS10975	COG1301	dicarboxylic acid transport
ESP47_RS10985	COG1328	CTP reductase activity
ESP47_RS10995	COG1063	alcohol dehydrogenase
ESP47_RS11000	COG3835	regulator
ESP47_RS11005	COG1929	Belongs to the glycerate kinase type-1 family
ESP47_RS11010	COG2610	gluconate transmembrane transporter activity
ESP47_RS11015	COG1879	ABC-type sugar transport system periplasmic component
ESP47_RS11020	COG1172	Belongs to the binding-protein-dependent transport system permease family
ESP47_RS11025	COG1129	ABC transporter
ESP47_RS11030	COG1869	D-ribose catabolic process
ESP47_RS11035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ESP47_RS11040	COG1609	Transcriptional regulator
ESP47_RS11080	COG4549	nuclear export factor GLE1
ESP47_RS11085	COG2372	response to copper ion
ESP47_RS11085	COG1276	copper resistance
ESP47_RS11095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ESP47_RS11100	COG1609	Transcriptional regulator
ESP47_RS11115	COG5002	protein histidine kinase activity
ESP47_RS11120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ESP47_RS11125	COG1278	Cold shock
ESP47_RS11130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ESP47_RS11150	COG0697	spore germination
ESP47_RS11155	COG1472	Belongs to the glycosyl hydrolase 3 family
ESP47_RS11170	COG3876	Protein conserved in bacteria
ESP47_RS11195	COG1132	(ABC) transporter
ESP47_RS11200	COG1132	(ABC) transporter
ESP47_RS11220	COG0791	NLP P60 protein
ESP47_RS11220	COG1388	LysM domain
ESP47_RS11240	COG2272	Belongs to the type-B carboxylesterase lipase family
ESP47_RS11245	COG0154	amidase activity
ESP47_RS11250	COG2814	Major facilitator Superfamily
ESP47_RS11255	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS11295	COG3153	acetyltransferase
ESP47_RS11295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ESP47_RS11300	COG5583	Uncharacterized small protein (DUF2292)
ESP47_RS11305	COG0431	NADPH-dependent FMN reductase
ESP47_RS11310	COG1116	anion transmembrane transporter activity
ESP47_RS11315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_RS11320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESP47_RS11325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESP47_RS11360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ESP47_RS11375	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ESP47_RS11385	COG2390	Transcriptional regulator
ESP47_RS11395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ESP47_RS11410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ESP47_RS11425	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ESP47_RS11430	COG1984	allophanate hydrolase subunit 2
ESP47_RS11435	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ESP47_RS11440	COG2814	Major facilitator Superfamily
ESP47_RS11445	COG1764	response to oxidative stress
ESP47_RS11450	COG1126	abc transporter atp-binding protein
ESP47_RS11455	COG0765	amino acid transport
ESP47_RS11460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_RS11470	COG0326	Molecular chaperone. Has ATPase activity
ESP47_RS11540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ESP47_RS11555	COG1064	alcohol dehydrogenase
ESP47_RS11580	COG2814	Major facilitator Superfamily
ESP47_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS11625	COG3716	PTS system mannose fructose sorbose family IID component
ESP47_RS11705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ESP47_RS11710	COG1597	lipid kinase activity
ESP47_RS11735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ESP47_RS11740	COG0154	amidase activity
ESP47_RS11745	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ESP47_RS11750	COG2224	Isocitrate lyase
ESP47_RS11755	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ESP47_RS11760	COG4851	CamS sex pheromone cAM373 precursor
ESP47_RS11770	COG0210	DNA helicase
ESP47_RS11775	COG0210	DNA helicase
ESP47_RS11780	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ESP47_RS11785	COG4496	protein, YerC YecD
ESP47_RS11790	COG1470	cell adhesion involved in biofilm formation
ESP47_RS11805	COG0151	Belongs to the GarS family
ESP47_RS11815	COG0138	bifunctional purine biosynthesis protein purh
ESP47_RS11820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ESP47_RS11825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ESP47_RS11830	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ESP47_RS11835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ESP47_RS11840	COG0047	phosphoribosylformylglycinamidine synthase activity
ESP47_RS11845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ESP47_RS11855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ESP47_RS11860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ESP47_RS11865	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ESP47_RS11875	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ESP47_RS11880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ESP47_RS11885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_RS11885	COG2190	(PTS) system
ESP47_RS11885	COG1263	PTS System
ESP47_RS11900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_RS11900	COG1263	PTS System
ESP47_RS11925	COG1301	dicarboxylic acid transport
ESP47_RS11935	COG3711	transcriptional antiterminator
ESP47_RS11945	COG2252	PERMEase
ESP47_RS11955	COG1132	(ABC) transporter
ESP47_RS11960	COG2814	Major facilitator Superfamily
ESP47_RS11965	COG2197	response regulator
ESP47_RS11970	COG3850	Histidine kinase
ESP47_RS11975	COG1131	(ABC) transporter
ESP47_RS11985	COG0842	Transport permease protein
ESP47_RS12000	COG0179	Fumarylacetoacetate (FAA) hydrolase
ESP47_RS12020	COG0824	Thioesterase
ESP47_RS12025	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_RS12030	COG0183	Belongs to the thiolase family
ESP47_RS12040	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESP47_RS12045	COG2508	Transcriptional regulator
ESP47_RS12050	COG2814	Major facilitator Superfamily
ESP47_RS12060	COG0179	Fumarylacetoacetate (FAA) hydrolase
ESP47_RS12070	COG0471	metal ion transport
ESP47_RS12095	COG1131	(ABC) transporter
ESP47_RS12100	COG1725	Transcriptional regulator
ESP47_RS12105	COG1695	Transcriptional regulator
ESP47_RS12110	COG3479	Phenolic acid decarboxylase
ESP47_RS12115	COG2910	NAD(P)H-binding
ESP47_RS12120	COG1959	2 iron, 2 sulfur cluster binding
ESP47_RS12145	COG0425	Belongs to the sulfur carrier protein TusA family
ESP47_RS12150	COG2391	methyltransferase activity
ESP47_RS12160	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS12180	COG1120	ATPase activity
ESP47_RS12185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESP47_RS12215	COG3620	sequence-specific DNA binding
ESP47_RS12230	COG0519	Catalyzes the synthesis of GMP from XMP
ESP47_RS12230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ESP47_RS12235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ESP47_RS12240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ESP47_RS12245	COG1335	isochorismatase
ESP47_RS12250	COG4948	Mandelate Racemase Muconate Lactonizing
ESP47_RS12260	COG0463	Glycosyl transferase, family 2
ESP47_RS12265	COG2246	polysaccharide biosynthetic process
ESP47_RS12270	COG0459	protein refolding
ESP47_RS12275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ESP47_RS12280	COG1266	CAAX protease self-immunity
ESP47_RS12290	COG0805	protein transport
ESP47_RS12295	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ESP47_RS12300	COG0488	(ABC) transporter
ESP47_RS12310	COG0456	acetyltransferase
ESP47_RS12315	COG1214	PFAM Peptidase M22, glycoprotease
ESP47_RS12320	COG0802	atpase or kinase
ESP47_RS12405	COG3091	SprT-like family
ESP47_RS12415	COG2183	response to ionizing radiation
ESP47_RS12420	COG2208	phosphoserine phosphatase activity
ESP47_RS12425	COG1191	sigma factor activity
ESP47_RS12430	COG2172	sigma factor antagonist activity
ESP47_RS12435	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_RS12445	COG2172	sigma factor antagonist activity
ESP47_RS12450	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_RS12455	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_RS12465	COG2337	Toxic component of a toxin-antitoxin (TA) module
ESP47_RS12470	COG0864	Transcriptional regulator
ESP47_RS12480	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ESP47_RS12485	COG0736	holo-[acyl-carrier-protein] synthase activity
ESP47_RS12490	COG0705	Rhomboid family
ESP47_RS12495	COG0513	Belongs to the DEAD box helicase family
ESP47_RS12505	COG1280	lysine exporter protein (LysE YggA)
ESP47_RS12515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESP47_RS12520	COG1609	Transcriptional regulator
ESP47_RS12525	COG0366	Alpha amylase catalytic
ESP47_RS12535	COG2182	Extracellular solute-binding protein
ESP47_RS12540	COG1175	transmembrane transport
ESP47_RS12545	COG3833	ABC-type maltose transport systems, permease component
ESP47_RS12555	COG1554	hydrolase, family 65, central catalytic
ESP47_RS12565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ESP47_RS12570	COG1181	Belongs to the D-alanine--D-alanine ligase family
ESP47_RS12580	COG1253	flavin adenine dinucleotide binding
ESP47_RS12585	COG0789	Transcriptional regulator
ESP47_RS12590	COG1253	flavin adenine dinucleotide binding
ESP47_RS12605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ESP47_RS12620	COG0629	single-stranded DNA binding
ESP47_RS12625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ESP47_RS12630	COG4786	Flagellar basal body rod
ESP47_RS12635	COG4786	Flagellar basal body rod
ESP47_RS12640	COG1077	Cell shape determining protein MreB Mrl
ESP47_RS12645	COG1609	Transcriptional regulator
ESP47_RS12650	COG0739	heme binding
ESP47_RS12655	COG2385	sporulation resulting in formation of a cellular spore
ESP47_RS12665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ESP47_RS12675	COG4836	Membrane
ESP47_RS12680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ESP47_RS12685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ESP47_RS12690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ESP47_RS12695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ESP47_RS12700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ESP47_RS12710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ESP47_RS12715	COG0356	it plays a direct role in the translocation of protons across the membrane
ESP47_RS12725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ESP47_RS12730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ESP47_RS12740	COG0698	ribose 5-phosphate isomerase
ESP47_RS12755	COG1971	Probably functions as a manganese efflux pump
ESP47_RS12760	COG0009	L-threonylcarbamoyladenylate synthase
ESP47_RS12775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ESP47_RS12785	COG1435	thymidine kinase activity
ESP47_RS12790	COG0254	rRNA binding
ESP47_RS12795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ESP47_RS12800	COG1494	fructose-1,6-bisphosphatase
ESP47_RS12805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ESP47_RS12810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ESP47_RS12815	COG0191	fructose-bisphosphate aldolase activity
ESP47_RS12820	COG2204	response regulator
ESP47_RS12835	COG1131	(ABC) transporter
ESP47_RS12840	COG1725	Transcriptional regulator
ESP47_RS12845	COG0504	CTP synthase activity
ESP47_RS12850	COG3343	RNA polymerase activity
ESP47_RS12860	COG1136	(ABC) transporter
ESP47_RS12870	COG1703	isobutyryl-CoA mutase activity
ESP47_RS12870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESP47_RS12870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESP47_RS12875	COG1309	transcriptional regulator
ESP47_RS12880	COG1960	acyl-CoA dehydrogenase activity
ESP47_RS12885	COG1960	acyl-CoA dehydrogenase activity
ESP47_RS12890	COG0183	Belongs to the thiolase family
ESP47_RS12895	COG2181	nitrate reductase activity
ESP47_RS12895	COG0247	lactate metabolic process
ESP47_RS12900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ESP47_RS12905	COG0018	arginyl-trna synthetase
ESP47_RS12915	COG0010	Belongs to the arginase family
ESP47_RS12920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ESP47_RS12930	COG1994	Peptidase M50
ESP47_RS12940	COG3465	dGTPase activity
ESP47_RS12945	COG1078	dGTPase activity
ESP47_RS12955	COG0095	Lipoate-protein ligase
ESP47_RS12960	COG0280	phosphate acetyltransferase
ESP47_RS12965	COG3253	May function as heme-dependent peroxidase
ESP47_RS12975	COG2363	Small membrane protein
ESP47_RS12985	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ESP47_RS13015	COG4555	ABC transporter
ESP47_RS13030	COG1121	(ABC) transporter
ESP47_RS13040	COG0351	phosphomethylpyrimidine kinase
ESP47_RS13055	COG0561	phosphatase activity
ESP47_RS13060	COG0514	ATP-dependent DNA helicase (RecQ)
ESP47_RS13065	COG1785	Belongs to the alkaline phosphatase family
ESP47_RS13070	COG1737	Transcriptional regulator
ESP47_RS13080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ESP47_RS13085	COG1346	cytolysis
ESP47_RS13090	COG1380	Effector of murein hydrolase LrgA
ESP47_RS13095	COG0583	DNA-binding transcription factor activity
ESP47_RS13100	COG0367	asparagine synthase
ESP47_RS13125	COG2966	Psort location CytoplasmicMembrane, score
ESP47_RS13130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ESP47_RS13135	COG1966	Carbon starvation protein
ESP47_RS13145	COG3275	phosphorelay sensor kinase activity
ESP47_RS13150	COG1464	Belongs to the NlpA lipoprotein family
ESP47_RS13155	COG2011	ABC-type metal ion transport system permease component
ESP47_RS13160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ESP47_RS13165	COG1119	ATPase activity
ESP47_RS13180	COG0534	Mate efflux family protein
ESP47_RS13185	COG1442	glycosyl transferase family 8
ESP47_RS13190	COG2195	Cleaves the N-terminal amino acid of tripeptides
ESP47_RS13195	COG2814	Major facilitator Superfamily
ESP47_RS13205	COG0028	Belongs to the TPP enzyme family
ESP47_RS13210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ESP47_RS13220	COG1132	(ABC) transporter
ESP47_RS13230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ESP47_RS13250	COG2188	Transcriptional regulator
ESP47_RS13255	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ESP47_RS13260	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_RS13265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_RS13270	COG0765	amino acid transport
ESP47_RS13275	COG1126	abc transporter atp-binding protein
ESP47_RS13295	COG3457	Alanine racemase
ESP47_RS13305	COG1126	abc transporter atp-binding protein
ESP47_RS13315	COG0765	amino acid transport
ESP47_RS13330	COG0579	oxidoreductase
ESP47_RS13335	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ESP47_RS13340	COG0732	type I restriction modification DNA specificity domain
ESP47_RS13425	COG1280	lysine exporter protein (LysE YggA)
ESP47_RS13435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ESP47_RS13460	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ESP47_RS13470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ESP47_RS13475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ESP47_RS13480	COG4853	Protein conserved in bacteria
ESP47_RS13485	COG4863	YycH protein
ESP47_RS13490	COG5002	protein histidine kinase activity
ESP47_RS13495	COG0745	RESPONSE REGULATOR receiver
ESP47_RS13510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ESP47_RS13515	COG0305	Participates in initiation and elongation during chromosome replication
ESP47_RS13520	COG0359	binds to the 23S rRNA
ESP47_RS13525	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ESP47_RS13535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ESP47_RS13545	COG0360	Binds together with S18 to 16S ribosomal RNA
ESP47_RS13550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ESP47_RS13555	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ESP47_RS13555	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ESP47_RS13560	COG0307	riboflavin synthase, alpha
ESP47_RS13565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ESP47_RS13565	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ESP47_RS13570	COG0012	GTP binding
ESP47_RS13575	COG4481	Protein conserved in bacteria
ESP47_RS13580	COG0668	transmembrane transport
ESP47_RS13595	COG1475	DNA binding
ESP47_RS13600	COG1192	Involved in chromosome partitioning
ESP47_RS13605	COG1475	DNA binding
ESP47_RS13610	COG0357	Ribosomal RNA small subunit methyltransferase G
ESP47_RS13615	COG0445	tRNA wobble uridine modification
ESP47_RS13620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ESP47_RS13625	COG1847	R3H domain protein
ESP47_RS13630	COG0706	membrane insertase activity
ESP47_RS13635	COG0594	ribonuclease P activity
ESP47_RS13640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ESP47_RS13645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ESP47_RS13650	COG0592	DNA-directed DNA polymerase activity
ESP47_RS13655	COG2501	S4 domain
ESP47_RS13660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ESP47_RS13670	COG0187	DNA topoisomerase II activity
ESP47_RS13675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ESP47_RS13680	COG3437	response regulator, receiver
ESP47_RS13720	COG1982	Orn Lys Arg decarboxylase major
ESP47_RS13730	COG3870	Protein conserved in bacteria
ESP47_RS13735	COG1728	Protein conserved in bacteria
ESP47_RS13740	COG0470	DNA polymerase III
ESP47_RS13745	COG1774	PSP1 C-terminal conserved region
ESP47_RS13750	COG4467	Involved in initiation control of chromosome replication
ESP47_RS13755	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ESP47_RS13760	COG2827	Endonuclease containing a URI domain
ESP47_RS13765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ESP47_RS13770	COG2002	toxin-antitoxin pair type II binding
ESP47_RS13780	COG0084	hydrolase, TatD family'
ESP47_RS13790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ESP47_RS13800	COG4466	Protein conserved in bacteria
ESP47_RS13810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ESP47_RS13815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ESP47_RS13820	COG0251	oxidation-reduction process
ESP47_RS13850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ESP47_RS13855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ESP47_RS13860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ESP47_RS13865	COG0193	aminoacyl-tRNA hydrolase activity
ESP47_RS13875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ESP47_RS13880	COG2002	toxin-antitoxin pair type II binding
ESP47_RS13885	COG2244	polysaccharide biosynthetic process
ESP47_RS13890	COG3956	TIGRFAM MazG family protein
ESP47_RS13895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ESP47_RS13915	COG1098	S1 RNA binding domain
ESP47_RS13925	COG2208	phosphoserine phosphatase activity
ESP47_RS13930	COG2304	oxidoreductase activity
ESP47_RS13935	COG0515	serine threonine protein kinase
ESP47_RS13940	COG0037	tRNA processing
ESP47_RS13945	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ESP47_RS13950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ESP47_RS13955	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ESP47_RS13960	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ESP47_RS13965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ESP47_RS13970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ESP47_RS13975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ESP47_RS13980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ESP47_RS14060	COG0517	IMP dehydrogenase activity
ESP47_RS14060	COG0516	GMP reductase activity
ESP47_RS14075	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ESP47_RS14085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ESP47_RS14095	COG1428	Deoxynucleoside kinase
ESP47_RS14100	COG1428	Deoxynucleoside kinase
ESP47_RS14105	COG3858	chitin binding
ESP47_RS14105	COG1388	LysM domain
ESP47_RS14135	COG0590	tRNA wobble adenosine to inosine editing
ESP47_RS14145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ESP47_RS14150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ESP47_RS14155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ESP47_RS14205	COG3880	PFAM UvrB UvrC protein
ESP47_RS14210	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ESP47_RS14215	COG0542	response to heat
ESP47_RS14220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ESP47_RS14225	COG4956	integral membrane protein (PIN domain superfamily)
ESP47_RS14235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ESP47_RS14240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ESP47_RS14245	COG1045	serine acetyltransferase
ESP47_RS14250	COG0215	cysteine-tRNA ligase activity
ESP47_RS14260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESP47_RS14265	COG3688	RNA-binding protein containing a PIN domain
ESP47_RS14275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ESP47_RS14280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ESP47_RS14285	COG0250	Participates in transcription elongation, termination and antitermination
ESP47_RS14290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ESP47_RS14295	COG0081	regulation of translation
ESP47_RS14300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ESP47_RS14305	COG0222	ribosome binding
ESP47_RS14310	COG2813	Specifically methylates the guanine in position
ESP47_RS14325	COG1358	cellular component organization or biogenesis
ESP47_RS14330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ESP47_RS14335	COG0049	tRNA binding
ESP47_RS14340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ESP47_RS14345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ESP47_RS14350	COG0051	transcription antitermination factor activity, RNA binding
ESP47_RS14360	COG0088	Forms part of the polypeptide exit tunnel
ESP47_RS14365	COG0089	rRNA binding
ESP47_RS14370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ESP47_RS14375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ESP47_RS14385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ESP47_RS14390	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ESP47_RS14395	COG0255	Belongs to the universal ribosomal protein uL29 family
ESP47_RS14400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ESP47_RS14405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ESP47_RS14410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ESP47_RS14420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ESP47_RS14425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ESP47_RS14430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ESP47_RS14435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ESP47_RS14440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ESP47_RS14450	COG0200	Binds to the 23S rRNA
ESP47_RS14455	COG0201	protein transport
ESP47_RS14460	COG0563	adenylate kinase activity
ESP47_RS14465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ESP47_RS14470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ESP47_RS14475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ESP47_RS14480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ESP47_RS14485	COG0202	RNA polymerase activity
ESP47_RS14490	COG0203	ribosomal protein L17
ESP47_RS14495	COG1122	ATPase activity
ESP47_RS14500	COG1122	ATPase activity
ESP47_RS14505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ESP47_RS14515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ESP47_RS14520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ESP47_RS14535	COG2046	Belongs to the sulfate adenylyltransferase family
ESP47_RS14540	COG0529	Catalyzes the synthesis of activated sulfate
ESP47_RS14545	COG0833	amino acid
ESP47_RS14555	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESP47_RS14560	COG0489	protein tyrosine kinase activity
ESP47_RS14570	COG2194	sulfuric ester hydrolase activity
ESP47_RS14585	COG0726	polysaccharide deacetylase
ESP47_RS14595	COG1271	oxidase subunit
ESP47_RS14600	COG1294	oxidase, subunit
ESP47_RS14610	COG4988	ABC transporter
ESP47_RS14615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ESP47_RS14620	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS14695	COG1525	nuclease
ESP47_RS14715	COG3620	sequence-specific DNA binding
ESP47_RS14760	COG5377	YqaJ viral recombinase family
ESP47_RS14765	COG3723	Recombinational DNA repair protein, rece pathway
ESP47_RS14770	COG3935	DnaD domain protein
ESP47_RS14780	COG0305	Participates in initiation and elongation during chromosome replication
ESP47_RS14940	COG3942	CHAP domain
ESP47_RS14940	COG1388	LysM domain
ESP47_RS14955	COG1595	DNA-templated transcription, initiation
ESP47_RS14960	COG5662	AntiSigma factor
ESP47_RS14965	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ESP47_RS14970	COG4856	YbbR-like protein
ESP47_RS14975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ESP47_RS14980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ESP47_RS15050	COG2814	Major facilitator Superfamily
ESP47_RS15055	COG0583	DNA-binding transcription factor activity
ESP47_RS15065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ESP47_RS15075	COG0840	transmembrane signaling receptor activity
ESP47_RS15090	COG1695	Transcriptional regulator
ESP47_RS15095	COG0840	transmembrane signaling receptor activity
ESP47_RS15100	COG0477	Major facilitator Superfamily
ESP47_RS15160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESP47_RS15165	COG2814	Major facilitator Superfamily
ESP47_RS15175	COG0519	Catalyzes the synthesis of GMP from XMP
ESP47_RS15200	COG0477	Major facilitator Superfamily
ESP47_RS15200	COG2814	Major facilitator Superfamily
ESP47_RS15250	COG3425	synthase
ESP47_RS15265	COG0183	Belongs to the thiolase family
ESP47_RS15295	COG0517	IMP dehydrogenase activity
ESP47_RS15295	COG1125	glycine betaine transport
ESP47_RS15300	COG1174	glycine betaine transport
ESP47_RS15305	COG2190	(PTS) system
ESP47_RS15310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_RS15310	COG1263	PTS System
ESP47_RS15315	COG0366	Alpha amylase catalytic
ESP47_RS15320	COG2188	Transcriptional regulator
ESP47_RS15330	COG1070	Carbohydrate kinase
ESP47_RS15340	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ESP47_RS15345	COG0716	FMN binding
ESP47_RS15360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ESP47_RS15370	COG2217	Heavy metal translocating P-type atpase
ESP47_RS15385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP47_RS15395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP47_RS15400	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ESP47_RS15405	COG0463	Glycosyl transferase, family 2
ESP47_RS15435	COG2076	Multidrug Resistance protein
ESP47_RS15440	COG2076	Multidrug Resistance protein
ESP47_RS15455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESP47_RS15460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESP47_RS15465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ESP47_RS15470	COG1120	ATPase activity
ESP47_RS15495	COG0217	transcriptional regulatory protein
ESP47_RS15500	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_RS15510	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS15520	COG1309	transcriptional regulator
ESP47_RS15540	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS15560	COG5434	Belongs to the glycosyl hydrolase 28 family
ESP47_RS15570	COG0175	sulfate reduction
ESP47_RS15590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ESP47_RS15600	COG0371	Dehydrogenase
ESP47_RS15605	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_RS15620	COG0697	spore germination
ESP47_RS15640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ESP47_RS15650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ESP47_RS15665	COG0702	epimerase
ESP47_RS15685	COG2213	PTS system mannitol-specific
ESP47_RS15685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_RS15690	COG3711	transcriptional antiterminator
ESP47_RS15695	COG0246	Mannitol dehydrogenase
ESP47_RS15700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ESP47_RS15720	COG2848	UPF0210 protein
ESP47_RS15725	COG1609	Transcriptional regulator
ESP47_RS15740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ESP47_RS15755	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ESP47_RS15765	COG5577	PFAM Coat F domain
ESP47_RS15770	COG0667	Aldo Keto reductase
ESP47_RS15780	COG1113	amino acid transport
ESP47_RS15790	COG3104	oligopeptide transport
ESP47_RS15795	COG0833	amino acid
ESP47_RS15805	COG3842	ATPase activity
ESP47_RS15810	COG1176	ABC-type spermidine putrescine transport system, permease component I
ESP47_RS15870	COG0531	amino acid
ESP47_RS15875	COG1556	Lactate utilization protein
ESP47_RS15880	COG1139	Iron-sulfur cluster binding protein
ESP47_RS15885	COG0247	lactate metabolic process
ESP47_RS15895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ESP47_RS15900	COG1454	alcohol dehydrogenase
ESP47_RS15910	COG1953	Uracil, thiamine, allantoin
ESP47_RS15935	COG0531	amino acid
ESP47_RS15940	COG1979	alcohol dehydrogenase
ESP47_RS15945	COG0004	ammonium transporteR
ESP47_RS15950	COG3290	protein histidine kinase activity
ESP47_RS15955	COG4565	transcriptional regulatory protein
ESP47_RS15960	COG2851	Citrate transporter
ESP47_RS15965	COG0463	Glycosyl transferase, family 2
ESP47_RS15970	COG3973	AAA domain
ESP47_RS15985	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ESP47_RS15995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ESP47_RS16000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ESP47_RS16005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ESP47_RS16010	COG1301	dicarboxylic acid transport
ESP47_RS16015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ESP47_RS16050	COG1902	pentaerythritol trinitrate reductase activity
ESP47_RS16070	COG0423	glycine-tRNA ligase activity
ESP47_RS16075	COG0531	amino acid
ESP47_RS16085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ESP47_RS16090	COG0628	permease
ESP47_RS16105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_RS16110	COG0765	amino acid transport
ESP47_RS16115	COG0765	amino acid transport
ESP47_RS16130	COG1733	regulation of RNA biosynthetic process
ESP47_RS16140	COG0586	Pfam SNARE associated Golgi protein
ESP47_RS16145	COG0586	Pfam SNARE associated Golgi protein
ESP47_RS16160	COG0646	methionine synthase
ESP47_RS16160	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ESP47_RS16165	COG0646	methionine synthase
ESP47_RS16165	COG1410	methionine synthase
ESP47_RS16195	COG3944	biosynthesis protein
ESP47_RS16200	COG0489	protein tyrosine kinase activity
ESP47_RS16205	COG4464	protein tyrosine phosphatase activity
ESP47_RS16210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ESP47_RS16215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ESP47_RS16250	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ESP47_RS16250	COG0662	Cupin 2, conserved barrel domain protein
ESP47_RS16255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ESP47_RS16285	COG1501	Belongs to the glycosyl hydrolase 31 family
ESP47_RS16295	COG2115	Belongs to the xylose isomerase family
ESP47_RS16300	COG1070	Carbohydrate kinase
ESP47_RS16330	COG1070	Carbohydrate kinase
ESP47_RS16340	COG1940	carbohydrate kinase activity
ESP47_RS16345	COG1063	alcohol dehydrogenase
ESP47_RS16370	COG4193	domain, Protein
ESP47_RS16390	COG5504	Zn-dependent protease
ESP47_RS16395	COG2226	methyltransferase
ESP47_RS16445	COG3716	PTS system mannose fructose sorbose family IID component
ESP47_RS16450	COG3715	PTS system
ESP47_RS16455	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_RS16460	COG0363	glucosamine-6-phosphate deaminase activity
ESP47_RS16465	COG2188	Transcriptional regulator
ESP47_RS16470	COG1396	sequence-specific DNA binding
ESP47_RS16480	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
ESP47_RS16485	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ESP47_RS16490	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ESP47_RS16490	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ESP47_RS16500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_RS16500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_RS16505	COG3715	PTS system
ESP47_RS16510	COG3716	PTS system mannose fructose sorbose family IID component
ESP47_RS16530	COG3414	Phosphotransferase system galactitol-specific IIB component
ESP47_RS16535	COG3775	system Galactitol-specific IIC component
ESP47_RS16545	COG1105	Belongs to the carbohydrate kinase PfkB family
ESP47_RS16550	COG0235	Class ii aldolase
ESP47_RS16570	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ESP47_RS16580	COG0145	ligase activity
ESP47_RS16590	COG2315	Protein conserved in bacteria
ESP47_RS16600	COG0658	competence protein
ESP47_RS16600	COG2333	competence protein COMEC
ESP47_RS16625	COG0531	amino acid
ESP47_RS16630	COG1316	TRANSCRIPTIONal
ESP47_RS16640	COG4989	oxidoreductase activity
ESP47_RS16670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ESP47_RS16675	COG2130	NADP-dependent
ESP47_RS16685	COG3711	transcriptional antiterminator
ESP47_RS16685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_RS16690	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESP47_RS16695	COG1447	Phosphotransferase system cellobiose-specific component IIA
ESP47_RS16705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESP47_RS16710	COG2211	Major facilitator Superfamily
ESP47_RS16710	COG2190	(PTS) system
ESP47_RS16715	COG1113	amino acid transport
ESP47_RS16730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ESP47_RS16740	COG2814	Major facilitator Superfamily
ESP47_RS16745	COG1609	Transcriptional regulator
ESP47_RS16755	COG1174	glycine betaine transport
ESP47_RS16760	COG1732	Glycine betaine
ESP47_RS16765	COG1174	glycine betaine transport
ESP47_RS16770	COG1125	glycine betaine transport
ESP47_RS16770	COG0517	IMP dehydrogenase activity
ESP47_RS16775	COG1510	regulation of RNA biosynthetic process
ESP47_RS16780	COG0110	maltose O-acetyltransferase activity
ESP47_RS16785	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS16805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESP47_RS16825	COG2272	Belongs to the type-B carboxylesterase lipase family
ESP47_RS16830	COG0606	chelatase, subunit chli
ESP47_RS16840	COG0371	Dehydrogenase
ESP47_RS16845	COG2814	Major facilitator Superfamily
ESP47_RS16850	COG1070	Carbohydrate kinase
ESP47_RS16855	COG2115	Belongs to the xylose isomerase family
ESP47_RS16870	COG0157	Belongs to the NadC ModD family
ESP47_RS16875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ESP47_RS16880	COG1104	cysteine desulfurase activity
ESP47_RS16890	COG2116	formate transmembrane transporter activity
ESP47_RS16920	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS16925	COG2610	gluconate transmembrane transporter activity
ESP47_RS16930	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS16940	COG3829	transcription factor binding
ESP47_RS16940	COG3290	protein histidine kinase activity
ESP47_RS16945	COG1501	Belongs to the glycosyl hydrolase 31 family
ESP47_RS16970	COG1309	transcriptional regulator
ESP47_RS16985	COG1363	Peptidase, m42
ESP47_RS17025	COG2972	Histidine kinase
ESP47_RS17045	COG0531	amino acid
ESP47_RS17055	COG1620	l-lactate permease
ESP47_RS17060	COG2186	Transcriptional regulator
ESP47_RS17115	COG1447	Phosphotransferase system cellobiose-specific component IIA
ESP47_RS17130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESP47_RS17130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESP47_RS17135	COG2723	6-phospho-beta-galactosidase activity
ESP47_RS17140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_RS17140	COG3711	transcriptional antiterminator
ESP47_RS17145	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ESP47_RS17155	COG1131	(ABC) transporter
ESP47_RS17165	COG0626	cystathionine gamma-synthase activity
ESP47_RS17170	COG0626	cystathionine gamma-synthase activity
ESP47_RS17190	COG1653	transport
ESP47_RS17195	COG2207	Transcriptional regulator
ESP47_RS17210	COG0604	alcohol dehydrogenase
ESP47_RS17215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ESP47_RS17220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ESP47_RS17245	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS17250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ESP47_RS17260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ESP47_RS17270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESP47_RS17275	COG1316	TRANSCRIPTIONal
ESP47_RS17280	COG1136	(ABC) transporter
ESP47_RS17280	COG0577	efflux transmembrane transporter activity
ESP47_RS17295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ESP47_RS17310	COG1388	LysM domain
ESP47_RS17310	COG3584	3D domain protein
ESP47_RS17320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ESP47_RS17330	COG0011	TIGRFAM Protein of
ESP47_RS17335	COG2706	6-phosphogluconolactonase activity
ESP47_RS17345	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ESP47_RS17345	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ESP47_RS17350	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_RS17350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_RS17360	COG3715	PTS system
ESP47_RS17365	COG3716	PTS system mannose fructose sorbose family IID component
ESP47_RS17380	COG2079	MmgE PrpD family protein
ESP47_RS17385	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ESP47_RS17395	COG0154	amidase activity
ESP47_RS17405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_RS17410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESP47_RS17415	COG1116	anion transmembrane transporter activity
ESP47_RS17420	COG0083	homoserine kinase activity
ESP47_RS17425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ESP47_RS17430	COG0460	homoserine dehydrogenase
ESP47_RS17435	COG0010	Belongs to the arginase family
ESP47_RS17445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ESP47_RS17450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ESP47_RS17460	COG4145	pantothenate transmembrane transporter activity
ESP47_RS17480	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_RS17480	COG1454	alcohol dehydrogenase
ESP47_RS17495	COG1388	LysM domain
ESP47_RS17495	COG0791	NLP P60 protein
ESP47_RS17500	COG0024	Methionine aminopeptidase
ESP47_RS17505	COG1268	BioY protein
ESP47_RS17515	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_RS17520	COG1960	acyl-CoA dehydrogenase activity
ESP47_RS17525	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_RS17530	COG2746	aminoglycoside 3-N-acetyltransferase activity
ESP47_RS17535	COG2244	polysaccharide biosynthetic process
ESP47_RS17540	COG0589	response to stress
ESP47_RS17555	COG0535	radical SAM domain protein
ESP47_RS17560	COG0457	Tetratricopeptide repeat
ESP47_RS17565	COG1063	alcohol dehydrogenase
ESP47_RS17580	COG1609	Transcriptional regulator
ESP47_RS17590	COG0561	phosphatase activity
ESP47_RS17610	COG0656	L-ascorbic acid biosynthetic process
ESP47_RS17620	COG0657	acetylesterase activity
ESP47_RS17625	COG0656	L-ascorbic acid biosynthetic process
ESP47_RS17630	COG0431	NADPH-dependent FMN reductase
ESP47_RS17635	COG0420	3'-5' exonuclease activity
ESP47_RS17640	COG4717	serine-type aminopeptidase activity
ESP47_RS17645	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESP47_RS17650	COG0534	Mate efflux family protein
ESP47_RS17665	COG0789	Transcriptional regulator
ESP47_RS17670	COG0436	Aminotransferase
ESP47_RS17675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ESP47_RS17685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis