locus-tag	class	description
BC6307_RS00050	COG0456	acetyltransferase
BC6307_RS00055	COG1304	FMN binding
BC6307_RS00060	COG2814	Major facilitator Superfamily
BC6307_RS00065	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BC6307_RS00070	COG1131	(ABC) transporter
BC6307_RS00090	COG1595	DNA-templated transcription, initiation
BC6307_RS00100	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BC6307_RS00110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BC6307_RS00115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BC6307_RS00120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BC6307_RS00125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BC6307_RS00130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BC6307_RS00135	COG0047	phosphoribosylformylglycinamidine synthase activity
BC6307_RS00140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BC6307_RS00145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BC6307_RS00150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BC6307_RS00155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BC6307_RS00165	COG0151	Belongs to the GarS family
BC6307_RS00175	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BC6307_RS00180	COG1470	cell adhesion involved in biofilm formation
BC6307_RS00185	COG4496	protein, YerC YecD
BC6307_RS00190	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BC6307_RS00195	COG0210	DNA helicase
BC6307_RS00200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BC6307_RS00205	COG4851	CamS sex pheromone cAM373 precursor
BC6307_RS00210	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_RS00215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC6307_RS00220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC6307_RS00225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BC6307_RS00230	COG0154	amidase activity
BC6307_RS00240	COG1263	PTS System
BC6307_RS00240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_RS00240	COG2190	(PTS) system
BC6307_RS00245	COG1585	Membrane protein implicated in regulation of membrane protease activity
BC6307_RS00250	COG2268	Band 7 protein
BC6307_RS00255	COG1597	lipid kinase activity
BC6307_RS00265	COG1902	pentaerythritol trinitrate reductase activity
BC6307_RS00280	COG1733	regulation of RNA biosynthetic process
BC6307_RS00285	COG2514	catechol 2,3-dioxygenase activity
BC6307_RS00300	COG0395	ABC-type sugar transport system, permease component
BC6307_RS00310	COG3842	ATPase activity
BC6307_RS00315	COG1473	amidohydrolase
BC6307_RS00325	COG4948	Mandelate Racemase Muconate Lactonizing
BC6307_RS00330	COG3949	Membrane
BC6307_RS00335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BC6307_RS00340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC6307_RS00345	COG4807	Protein conserved in bacteria
BC6307_RS00350	COG1595	DNA-templated transcription, initiation
BC6307_RS00375	COG0167	dihydroorotate dehydrogenase activity
BC6307_RS00380	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BC6307_RS00405	COG2258	MOSC domain
BC6307_RS00410	COG2239	Acts as a magnesium transporter
BC6307_RS00440	COG1193	negative regulation of DNA recombination
BC6307_RS00445	COG1272	protein, Hemolysin III
BC6307_RS00465	COG2723	6-phospho-beta-galactosidase activity
BC6307_RS00475	COG1175	transmembrane transport
BC6307_RS00480	COG0395	ABC-type sugar transport system, permease component
BC6307_RS00485	COG5578	integral membrane protein
BC6307_RS00510	COG1595	DNA-templated transcription, initiation
BC6307_RS00525	COG4521	taurine ABC transporter
BC6307_RS00530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC6307_RS00535	COG1116	anion transmembrane transporter activity
BC6307_RS00540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC6307_RS00555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC6307_RS00575	COG0514	ATP-dependent DNA helicase (RecQ)
BC6307_RS00580	COG0745	RESPONSE REGULATOR receiver
BC6307_RS00600	COG1785	Belongs to the alkaline phosphatase family
BC6307_RS00620	COG2358	TRAP transporter, solute receptor (TAXI family
BC6307_RS00630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS00655	COG0861	Integral membrane protein TerC family
BC6307_RS00670	COG0346	lactoylglutathione lyase activity
BC6307_RS00675	COG1027	Aspartate ammonia-lyase
BC6307_RS00685	COG2076	Multidrug Resistance protein
BC6307_RS00695	COG1309	transcriptional regulator
BC6307_RS00745	COG1695	Transcriptional regulator
BC6307_RS00760	COG2409	Drug exporters of the RND superfamily
BC6307_RS00770	COG4895	conserved protein (DUF2196)
BC6307_RS00785	COG2502	aspartate--ammonia ligase
BC6307_RS00795	COG1408	metallophosphoesterase
BC6307_RS00800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BC6307_RS00800	COG4451	ribulose bisphosphate carboxylase, small
BC6307_RS00805	COG0745	RESPONSE REGULATOR receiver
BC6307_RS00810	COG5002	protein histidine kinase activity
BC6307_RS00815	COG1136	(ABC) transporter
BC6307_RS00825	COG0517	IMP dehydrogenase activity
BC6307_RS00825	COG4175	Glycine betaine
BC6307_RS00840	COG1737	Transcriptional regulator
BC6307_RS00845	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BC6307_RS00850	COG2610	gluconate transmembrane transporter activity
BC6307_RS00855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC6307_RS00860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC6307_RS00865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC6307_RS00870	COG1120	ATPase activity
BC6307_RS00875	COG0492	ferredoxin-NADP+ reductase activity
BC6307_RS00880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC6307_RS00885	COG0390	transport system, permease component
BC6307_RS00900	COG1183	phosphatidylcholine synthase activity
BC6307_RS00905	COG1609	Transcriptional regulator
BC6307_RS00910	COG0166	Belongs to the GPI family
BC6307_RS00925	COG3173	Aminoglycoside phosphotransferase
BC6307_RS00930	COG0154	amidase activity
BC6307_RS00940	COG2368	4-hydroxyphenylacetate
BC6307_RS00955	COG0084	hydrolase, TatD family'
BC6307_RS00960	COG1132	(ABC) transporter
BC6307_RS00965	COG1132	(ABC) transporter
BC6307_RS00975	COG1115	amino acid carrier protein
BC6307_RS00980	COG0723	plastoquinol--plastocyanin reductase activity
BC6307_RS00980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC6307_RS00990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC6307_RS01005	COG1309	transcriptional regulator
BC6307_RS01010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BC6307_RS01020	COG0145	ligase activity
BC6307_RS01025	COG2124	cytochrome p450
BC6307_RS01035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC6307_RS01045	COG2244	polysaccharide biosynthetic process
BC6307_RS01055	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BC6307_RS01070	COG1077	Cell shape determining protein MreB Mrl
BC6307_RS01095	COG2814	Major facilitator Superfamily
BC6307_RS01110	COG1115	amino acid carrier protein
BC6307_RS01125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS01135	COG1904	glucuronate isomerase
BC6307_RS01140	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BC6307_RS01145	COG2207	Transcriptional regulator
BC6307_RS01145	COG1917	Cupin 2, conserved barrel domain protein
BC6307_RS01155	COG0673	inositol 2-dehydrogenase activity
BC6307_RS01160	COG0673	inositol 2-dehydrogenase activity
BC6307_RS01170	COG2211	Major facilitator Superfamily
BC6307_RS01175	COG2211	Major facilitator Superfamily
BC6307_RS01180	COG1940	carbohydrate kinase activity
BC6307_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS01195	COG1606	tRNA processing
BC6307_RS01200	COG1070	Carbohydrate kinase
BC6307_RS01205	COG1691	(AIR) carboxylase
BC6307_RS01210	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BC6307_RS01215	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BC6307_RS01220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BC6307_RS01225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BC6307_RS01235	COG5002	protein histidine kinase activity
BC6307_RS01240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC6307_RS01265	COG1988	membrane-bound metal-dependent
BC6307_RS01270	COG4840	Belongs to the UPF0435 family
BC6307_RS01275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC6307_RS01285	COG1295	ribonuclease BN
BC6307_RS01305	COG2217	Heavy metal translocating P-type atpase
BC6307_RS01310	COG0477	Major facilitator Superfamily
BC6307_RS01320	COG2364	Membrane
BC6307_RS01340	COG0535	radical SAM domain protein
BC6307_RS01420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC6307_RS01425	COG1104	cysteine desulfurase activity
BC6307_RS01430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS01435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS01435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS01440	COG2814	Major facilitator Superfamily
BC6307_RS01445	COG1196	nuclear chromosome segregation
BC6307_RS01495	COG0785	Cytochrome C biogenesis protein
BC6307_RS01500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_RS01505	COG0745	RESPONSE REGULATOR receiver
BC6307_RS01510	COG3850	Histidine kinase
BC6307_RS01510	COG5002	protein histidine kinase activity
BC6307_RS01515	COG0737	Belongs to the 5'-nucleotidase family
BC6307_RS01530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS01530	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS01535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS01535	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS01540	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_RS01545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS01545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS01550	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS01560	COG0288	reversible hydration of carbon dioxide
BC6307_RS01585	COG1937	Protein conserved in bacteria
BC6307_RS01590	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS01595	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_RS01605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS01610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS01610	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS01620	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_RS01625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS01625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS01630	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS01640	COG0662	Cupin 2, conserved barrel domain protein
BC6307_RS01645	COG0446	pyridine nucleotide-disulphide oxidoreductase
BC6307_RS01660	COG0653	protein targeting
BC6307_RS01670	COG0515	serine threonine protein kinase
BC6307_RS01735	COG3773	Cell wall hydrolase
BC6307_RS01750	COG0697	spore germination
BC6307_RS01765	COG0402	S-adenosylhomocysteine deaminase activity
BC6307_RS01785	COG1114	Component of the transport system for branched-chain amino acids
BC6307_RS01790	COG0659	secondary active sulfate transmembrane transporter activity
BC6307_RS01810	COG1063	alcohol dehydrogenase
BC6307_RS01840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BC6307_RS01850	COG1307	EDD domain protein, DegV family
BC6307_RS01865	COG3829	transcription factor binding
BC6307_RS01865	COG3290	protein histidine kinase activity
BC6307_RS01875	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_RS01880	COG0564	pseudouridine synthase activity
BC6307_RS01885	COG1329	Transcriptional regulator
BC6307_RS01905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BC6307_RS01910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC6307_RS01925	COG0109	protoheme IX farnesyltransferase activity
BC6307_RS01930	COG1959	2 iron, 2 sulfur cluster binding
BC6307_RS01935	COG2910	NAD(P)H-binding
BC6307_RS01945	COG3481	metal-dependent phosphohydrolase, HD sub domain
BC6307_RS01960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BC6307_RS01970	COG1136	(ABC) transporter
BC6307_RS01990	COG3620	sequence-specific DNA binding
BC6307_RS02005	COG2072	flavoprotein involved in K transport
BC6307_RS02010	COG2217	Heavy metal translocating P-type atpase
BC6307_RS02015	COG3300	MHYT domain
BC6307_RS02015	COG5001	Diguanylate cyclase
BC6307_RS02020	COG0697	spore germination
BC6307_RS02025	COG0814	amino acid
BC6307_RS02050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BC6307_RS02060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BC6307_RS02075	COG0640	Transcriptional regulator
BC6307_RS02080	COG3832	glyoxalase III activity
BC6307_RS02085	COG3706	GGDEF domain
BC6307_RS02095	COG2323	membrane
BC6307_RS02100	COG0038	chloride channel
BC6307_RS02110	COG4555	ABC transporter
BC6307_RS02120	COG0656	L-ascorbic acid biosynthetic process
BC6307_RS02125	COG1131	(ABC) transporter
BC6307_RS02130	COG0842	Transport permease protein
BC6307_RS02130	COG1511	domain protein
BC6307_RS02140	COG1363	Peptidase, m42
BC6307_RS02170	COG0673	inositol 2-dehydrogenase activity
BC6307_RS02175	COG0673	inositol 2-dehydrogenase activity
BC6307_RS02200	COG2233	PERMEase
BC6307_RS02215	COG0840	transmembrane signaling receptor activity
BC6307_RS02220	COG0460	homoserine dehydrogenase
BC6307_RS02225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BC6307_RS02230	COG0083	homoserine kinase activity
BC6307_RS02235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BC6307_RS02240	COG0129	dihydroxy-acid dehydratase activity
BC6307_RS02245	COG0028	Belongs to the TPP enzyme family
BC6307_RS02250	COG0440	acetolactate synthase activity
BC6307_RS02255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BC6307_RS02260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BC6307_RS02270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BC6307_RS02275	COG0066	3-isopropylmalate dehydratase activity
BC6307_RS02280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BC6307_RS02285	COG1404	Belongs to the peptidase S8 family
BC6307_RS02290	COG2208	phosphoserine phosphatase activity
BC6307_RS02295	COG0596	Alpha beta hydrolase
BC6307_RS02315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BC6307_RS02315	COG0493	'glutamate synthase
BC6307_RS02325	COG0686	Belongs to the AlaDH PNT family
BC6307_RS02330	COG2508	Transcriptional regulator
BC6307_RS02330	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BC6307_RS02340	COG2409	Drug exporters of the RND superfamily
BC6307_RS02350	COG2814	Major facilitator Superfamily
BC6307_RS02365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BC6307_RS02375	COG1595	DNA-templated transcription, initiation
BC6307_RS02380	COG1757	Na H antiporter
BC6307_RS02385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BC6307_RS02390	COG3842	ATPase activity
BC6307_RS02400	COG0395	ABC-type sugar transport system, permease component
BC6307_RS02405	COG1653	transport
BC6307_RS02420	COG0733	neurotransmitter:sodium symporter activity
BC6307_RS02450	COG5577	PFAM Coat F domain
BC6307_RS02465	COG0427	acetyl-CoA hydrolase
BC6307_RS02470	COG1619	proteins homologs of microcin C7 resistance protein MccF
BC6307_RS02475	COG1834	amidinotransferase
BC6307_RS02480	COG2205	protein histidine kinase activity
BC6307_RS02485	COG2211	Major facilitator Superfamily
BC6307_RS02490	COG2329	Antibiotic biosynthesis monooxygenase
BC6307_RS02500	COG1280	lysine exporter protein (LysE YggA)
BC6307_RS02545	COG0534	Mate efflux family protein
BC6307_RS02550	COG1309	transcriptional regulator
BC6307_RS02555	COG2814	Major facilitator Superfamily
BC6307_RS02590	COG3279	Response regulator of the LytR AlgR family
BC6307_RS02595	COG4555	ABC transporter
BC6307_RS02600	COG1668	transmembrane transport
BC6307_RS02610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC6307_RS02620	COG1960	acyl-CoA dehydrogenase activity
BC6307_RS02630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC6307_RS02635	COG1846	Transcriptional regulator
BC6307_RS02640	COG2814	Major facilitator Superfamily
BC6307_RS02645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BC6307_RS02660	COG1757	Na H antiporter
BC6307_RS02685	COG1228	amidohydrolase
BC6307_RS02690	COG1090	epimerase
BC6307_RS02700	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS02725	COG1988	membrane-bound metal-dependent
BC6307_RS02730	COG1194	a g-specific adenine glycosylase
BC6307_RS02750	COG3557	Belongs to the UPF0374 family
BC6307_RS02755	COG1132	(ABC) transporter
BC6307_RS02760	COG4129	membrane
BC6307_RS02770	COG0070	glutamate synthase
BC6307_RS02770	COG0067	glutamate synthase
BC6307_RS02770	COG0069	glutamate synthase activity
BC6307_RS02790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BC6307_RS02795	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BC6307_RS02800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC6307_RS02805	COG2096	Adenosyltransferase
BC6307_RS02810	COG0735	belongs to the Fur family
BC6307_RS02925	COG3382	B3 4 domain protein
BC6307_RS02940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BC6307_RS02945	COG2766	serine protein kinase
BC6307_RS02950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC6307_RS02960	COG0747	negative chemotaxis
BC6307_RS02970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC6307_RS02975	COG0601	transmembrane transport
BC6307_RS02980	COG0444	Belongs to the ABC transporter superfamily
BC6307_RS02985	COG4608	Belongs to the ABC transporter superfamily
BC6307_RS02990	COG0697	spore germination
BC6307_RS03025	COG0372	Belongs to the citrate synthase family
BC6307_RS03030	COG0583	DNA-binding transcription factor activity
BC6307_RS03045	COG0708	Exodeoxyribonuclease III
BC6307_RS03050	COG4607	ABC-type enterochelin transport system periplasmic component
BC6307_RS03055	COG4667	esterase of the alpha-beta hydrolase superfamily
BC6307_RS03060	COG1164	Oligoendopeptidase f
BC6307_RS03065	COG4191	Histidine kinase
BC6307_RS03070	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC6307_RS03075	COG4605	iron ion homeostasis
BC6307_RS03080	COG4604	ABC transporter, ATP-binding protein
BC6307_RS03085	COG4607	ABC-type enterochelin transport system periplasmic component
BC6307_RS03090	COG4536	flavin adenine dinucleotide binding
BC6307_RS03100	COG0840	transmembrane signaling receptor activity
BC6307_RS03110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BC6307_RS03130	COG1968	undecaprenyl-diphosphatase activity
BC6307_RS03135	COG2205	protein histidine kinase activity
BC6307_RS03145	COG0789	Transcriptional regulator
BC6307_RS03165	COG0564	pseudouridine synthase activity
BC6307_RS03180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BC6307_RS03195	COG1228	amidohydrolase
BC6307_RS03210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC6307_RS03210	COG3153	acetyltransferase
BC6307_RS03215	COG1388	LysM domain
BC6307_RS03215	COG0791	NLP P60 protein
BC6307_RS03230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC6307_RS03235	COG4585	Histidine kinase
BC6307_RS03235	COG2203	Gaf domain
BC6307_RS03240	COG2197	response regulator
BC6307_RS03245	COG0431	NADPH-dependent FMN reductase
BC6307_RS03260	COG2239	Acts as a magnesium transporter
BC6307_RS03265	COG0730	response to heat
BC6307_RS03270	COG2719	SpoVR family
BC6307_RS03300	COG0640	Transcriptional regulator
BC6307_RS03305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC6307_RS03310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC6307_RS03315	COG0154	amidase activity
BC6307_RS03335	COG1794	racemase activity, acting on amino acids and derivatives
BC6307_RS03340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC6307_RS03345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BC6307_RS03370	COG1131	(ABC) transporter
BC6307_RS03385	COG0582	viral genome integration into host DNA
BC6307_RS03400	COG0534	Mate efflux family protein
BC6307_RS03405	COG2814	Major facilitator Superfamily
BC6307_RS03415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BC6307_RS03430	COG0521	Mo-molybdopterin cofactor biosynthetic process
BC6307_RS03435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BC6307_RS03450	COG0303	'Molybdopterin
BC6307_RS03455	COG1763	Mo-molybdopterin cofactor biosynthetic process
BC6307_RS03460	COG0314	molybdopterin synthase activity
BC6307_RS03465	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BC6307_RS03490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BC6307_RS03495	COG0746	molybdenum cofactor guanylyltransferase activity
BC6307_RS03500	COG0535	radical SAM domain protein
BC6307_RS03505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BC6307_RS03510	COG0489	protein tyrosine kinase activity
BC6307_RS03520	COG0243	molybdopterin cofactor binding
BC6307_RS03525	COG0437	4 iron, 4 sulfur cluster binding
BC6307_RS03540	COG1686	Belongs to the peptidase S11 family
BC6307_RS03555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC6307_RS03590	COG1078	dGTPase activity
BC6307_RS03595	COG0586	Pfam SNARE associated Golgi protein
BC6307_RS03605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC6307_RS03610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC6307_RS03620	COG1301	dicarboxylic acid transport
BC6307_RS03630	COG1970	mechanosensitive ion channel activity
BC6307_RS03640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC6307_RS03650	COG0393	Putative heavy-metal-binding
BC6307_RS03655	COG3773	Cell wall hydrolase
BC6307_RS03670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BC6307_RS03680	COG1122	ATPase activity
BC6307_RS03690	COG0352	thiamine-phosphate diphosphorylase activity
BC6307_RS03695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC6307_RS03700	COG2104	thiamine diphosphate biosynthetic process
BC6307_RS03705	COG2022	thiamine diphosphate biosynthetic process
BC6307_RS03710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BC6307_RS03715	COG0351	phosphomethylpyrimidine kinase
BC6307_RS03725	COG4989	oxidoreductase activity
BC6307_RS03740	COG1607	acyl-coa hydrolase
BC6307_RS03755	COG1132	(ABC) transporter
BC6307_RS03760	COG1132	(ABC) transporter
BC6307_RS03765	COG1253	flavin adenine dinucleotide binding
BC6307_RS03780	COG3842	ATPase activity
BC6307_RS03785	COG2508	Transcriptional regulator
BC6307_RS03800	COG0189	ligase activity
BC6307_RS03805	COG0189	ligase activity
BC6307_RS03810	COG0189	ligase activity
BC6307_RS03815	COG0189	ligase activity
BC6307_RS03825	COG3679	Belongs to the UPF0342 family
BC6307_RS03830	COG0561	phosphatase activity
BC6307_RS03835	COG1131	(ABC) transporter
BC6307_RS03840	COG0842	Transport permease protein
BC6307_RS03845	COG4585	Histidine kinase
BC6307_RS03850	COG2197	response regulator
BC6307_RS03855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BC6307_RS03860	COG4412	M6 family metalloprotease domain protein
BC6307_RS03860	COG1404	Belongs to the peptidase S8 family
BC6307_RS03880	COG0681	Belongs to the peptidase S26 family
BC6307_RS03885	COG1024	Enoyl-CoA hydratase
BC6307_RS03895	COG0420	3'-5' exonuclease activity
BC6307_RS03900	COG4717	serine-type aminopeptidase activity
BC6307_RS03905	COG3481	metal-dependent phosphohydrolase, HD sub domain
BC6307_RS03915	COG2233	PERMEase
BC6307_RS03920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC6307_RS03950	COG1846	Transcriptional regulator
BC6307_RS03970	COG0537	adenosine 5'-monophosphoramidase activity
BC6307_RS03975	COG1131	(ABC) transporter
BC6307_RS03980	COG4473	ABC transporter
BC6307_RS03990	COG1473	amidohydrolase
BC6307_RS04005	COG4585	Histidine kinase
BC6307_RS04010	COG2197	response regulator
BC6307_RS04015	COG2329	Antibiotic biosynthesis monooxygenase
BC6307_RS04020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC6307_RS04030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BC6307_RS04035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BC6307_RS04040	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BC6307_RS04050	COG1609	Transcriptional regulator
BC6307_RS04060	COG1234	tRNA 3'-trailer cleavage
BC6307_RS04065	COG0095	Lipoate-protein ligase
BC6307_RS04070	COG0318	PFAM AMP-dependent synthetase and ligase
BC6307_RS04075	COG1024	Enoyl-CoA hydratase
BC6307_RS04085	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BC6307_RS04095	COG1999	signal sequence binding
BC6307_RS04100	COG0501	Belongs to the peptidase M48B family
BC6307_RS04115	COG2323	membrane
BC6307_RS04125	COG0823	Involved in the tonB-independent uptake of proteins
BC6307_RS04130	COG0398	Pfam SNARE associated Golgi protein
BC6307_RS04140	COG0183	Belongs to the thiolase family
BC6307_RS04160	COG0411	ABC transporter
BC6307_RS04170	COG0559	Belongs to the binding-protein-dependent transport system permease family
BC6307_RS04180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC6307_RS04190	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS04195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC6307_RS04200	COG0318	PFAM AMP-dependent synthetase and ligase
BC6307_RS04210	COG0706	membrane insertase activity
BC6307_RS04215	COG2814	Major facilitator Superfamily
BC6307_RS04220	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BC6307_RS04225	COG1074	ATP-dependent DNA helicase activity
BC6307_RS04230	COG0420	3'-5' exonuclease activity
BC6307_RS04235	COG0419	ATPase involved in DNA repair
BC6307_RS04240	COG1403	HNH endonuclease
BC6307_RS04280	COG2311	Membrane
BC6307_RS04290	COG0179	Fumarylacetoacetate (FAA) hydrolase
BC6307_RS04295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BC6307_RS04305	COG3300	MHYT domain
BC6307_RS04305	COG5001	Diguanylate cyclase
BC6307_RS04315	COG0367	asparagine synthase
BC6307_RS04320	COG0004	ammonium transporteR
BC6307_RS04330	COG0534	Mate efflux family protein
BC6307_RS04335	COG1917	Cupin 2, conserved barrel domain protein
BC6307_RS04335	COG2207	Transcriptional regulator
BC6307_RS04345	COG2182	Extracellular solute-binding protein
BC6307_RS04350	COG1175	transmembrane transport
BC6307_RS04355	COG3833	ABC-type maltose transport systems, permease component
BC6307_RS04360	COG0366	Alpha amylase catalytic
BC6307_RS04360	COG1874	Beta-galactosidase
BC6307_RS04365	COG1609	Transcriptional regulator
BC6307_RS04370	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS04380	COG1666	GTP binding
BC6307_RS04385	COG2996	Protein conserved in bacteria
BC6307_RS04395	COG1307	EDD domain protein, DegV family
BC6307_RS04400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC6307_RS04415	COG0561	phosphatase activity
BC6307_RS04420	COG1073	alpha beta
BC6307_RS04425	COG2151	metal-sulfur cluster biosynthetic enzyme
BC6307_RS04435	COG0542	response to heat
BC6307_RS04445	COG2267	carboxylic ester hydrolase activity
BC6307_RS04455	COG1744	ABC transporter substrate-binding protein PnrA-like
BC6307_RS04470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC6307_RS04475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC6307_RS04480	COG5504	Zn-dependent protease
BC6307_RS04485	COG0444	Belongs to the ABC transporter superfamily
BC6307_RS04490	COG4608	Belongs to the ABC transporter superfamily
BC6307_RS04500	COG0601	transmembrane transport
BC6307_RS04505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC6307_RS04520	COG0180	Tryptophanyl-tRNA synthetase
BC6307_RS04535	COG1473	amidohydrolase
BC6307_RS04550	COG0601	transmembrane transport
BC6307_RS04555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC6307_RS04560	COG0444	Belongs to the ABC transporter superfamily
BC6307_RS04565	COG4608	Belongs to the ABC transporter superfamily
BC6307_RS04580	COG0456	acetyltransferase
BC6307_RS04600	COG1393	Belongs to the ArsC family
BC6307_RS04610	COG3344	reverse transcriptase
BC6307_RS04615	COG0861	Integral membrane protein TerC family
BC6307_RS04625	COG4862	establishment of competence for transformation
BC6307_RS04630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC6307_RS04640	COG1164	Oligoendopeptidase f
BC6307_RS04655	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BC6307_RS04660	COG2346	COG2346, Truncated hemoglobins
BC6307_RS04665	COG0741	lytic transglycosylase activity
BC6307_RS04670	COG4116	CYTH
BC6307_RS04680	COG2357	RelA SpoT domain protein
BC6307_RS04690	COG0564	pseudouridine synthase activity
BC6307_RS04695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BC6307_RS04700	COG0772	Belongs to the SEDS family
BC6307_RS04705	COG0475	glutathione-regulated potassium exporter activity
BC6307_RS04705	COG0589	response to stress
BC6307_RS04760	COG0438	transferase activity, transferring glycosyl groups
BC6307_RS04810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BC6307_RS04815	COG0463	Glycosyl transferase, family 2
BC6307_RS04860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC6307_RS04875	COG2323	membrane
BC6307_RS04915	COG0210	DNA helicase
BC6307_RS04925	COG2323	membrane
BC6307_RS04930	COG3385	transposase activity
BC6307_RS04945	COG2153	protein acetylation
BC6307_RS04950	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BC6307_RS04955	COG2382	esterase
BC6307_RS04960	COG1116	anion transmembrane transporter activity
BC6307_RS04975	COG1999	signal sequence binding
BC6307_RS04985	COG1418	mRNA catabolic process
BC6307_RS05030	COG2720	vancomycin resistance protein
BC6307_RS05040	COG1802	Transcriptional regulator
BC6307_RS05050	COG0601	transmembrane transport
BC6307_RS05055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC6307_RS05065	COG1124	(ABC) transporter
BC6307_RS05070	COG1114	Component of the transport system for branched-chain amino acids
BC6307_RS05095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC6307_RS05120	COG2188	Transcriptional regulator
BC6307_RS05125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_RS05125	COG1263	PTS System
BC6307_RS05130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BC6307_RS05135	COG4844	belongs to the
BC6307_RS05165	COG2270	Major facilitator Superfamily
BC6307_RS05180	COG0693	protein deglycase activity
BC6307_RS05220	COG5002	protein histidine kinase activity
BC6307_RS05240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BC6307_RS05245	COG2146	nitrite reductase [NAD(P)H] activity
BC6307_RS05250	COG1587	Uroporphyrinogen-III synthase
BC6307_RS05250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BC6307_RS05255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BC6307_RS05260	COG1177	transmembrane transport
BC6307_RS05265	COG1176	ABC-type spermidine putrescine transport system, permease component I
BC6307_RS05270	COG3842	ATPase activity
BC6307_RS05275	COG1132	(ABC) transporter
BC6307_RS05300	COG0789	Transcriptional regulator
BC6307_RS05310	COG2112	serine threonine protein kinase
BC6307_RS05315	COG0438	transferase activity, transferring glycosyl groups
BC6307_RS05320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BC6307_RS05325	COG4191	Histidine kinase
BC6307_RS05330	COG2105	PFAM AIG2 family protein
BC6307_RS05330	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BC6307_RS05340	COG1979	alcohol dehydrogenase
BC6307_RS05345	COG2304	oxidoreductase activity
BC6307_RS05350	COG4129	membrane
BC6307_RS05435	COG2814	Major facilitator Superfamily
BC6307_RS05440	COG1595	DNA-templated transcription, initiation
BC6307_RS05460	COG4533	DNA binding
BC6307_RS05470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BC6307_RS05475	COG5278	phosphoserine phosphatase activity
BC6307_RS05475	COG0840	transmembrane signaling receptor activity
BC6307_RS05480	COG3340	Belongs to the peptidase S51 family
BC6307_RS05485	COG2207	Transcriptional regulator
BC6307_RS05490	COG0789	Transcriptional regulator
BC6307_RS05495	COG2365	Tyrosine phosphatase family
BC6307_RS05500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC6307_RS05505	COG0765	amino acid transport
BC6307_RS05510	COG1126	abc transporter atp-binding protein
BC6307_RS05525	COG1132	(ABC) transporter
BC6307_RS05555	COG0697	spore germination
BC6307_RS05560	COG0628	permease
BC6307_RS05595	COG4251	negative regulation of phosphorylation
BC6307_RS05595	COG3706	GGDEF domain
BC6307_RS05595	COG2203	Gaf domain
BC6307_RS05595	COG5001	Diguanylate cyclase
BC6307_RS05610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BC6307_RS05615	COG0579	oxidoreductase
BC6307_RS05620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BC6307_RS05630	COG1649	PFAM Uncharacterised BCR, COG1649
BC6307_RS05635	COG3773	Cell wall hydrolase
BC6307_RS05650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC6307_RS05670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BC6307_RS05675	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_RS05685	COG0823	Involved in the tonB-independent uptake of proteins
BC6307_RS05685	COG1506	peptidase
BC6307_RS05685	COG4946	Tricorn protease homolog
BC6307_RS05690	COG1609	Transcriptional regulator
BC6307_RS05695	COG1263	PTS System
BC6307_RS05695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_RS05700	COG1621	beta-fructofuranosidase activity
BC6307_RS05705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC6307_RS05710	COG0702	epimerase
BC6307_RS05720	COG0753	catalase activity
BC6307_RS05730	COG1396	sequence-specific DNA binding
BC6307_RS05740	COG0657	acetylesterase activity
BC6307_RS05745	COG0561	phosphatase activity
BC6307_RS05750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BC6307_RS05755	COG0583	DNA-binding transcription factor activity
BC6307_RS05765	COG1595	DNA-templated transcription, initiation
BC6307_RS05790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BC6307_RS05820	COG1476	TRANSCRIPTIONal
BC6307_RS05845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC6307_RS05855	COG2851	Citrate transporter
BC6307_RS05860	COG4565	transcriptional regulatory protein
BC6307_RS05865	COG3290	protein histidine kinase activity
BC6307_RS05870	COG3300	MHYT domain
BC6307_RS05870	COG5001	Diguanylate cyclase
BC6307_RS05880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BC6307_RS05895	COG0450	alkyl hydroperoxide reductase
BC6307_RS05900	COG3634	alkyl hydroperoxide reductase activity
BC6307_RS05935	COG5578	integral membrane protein
BC6307_RS05945	COG3458	cephalosporin-C deacetylase activity
BC6307_RS05950	COG1737	Transcriptional regulator
BC6307_RS05960	COG4209	transmembrane transport
BC6307_RS05965	COG0395	ABC-type sugar transport system, permease component
BC6307_RS05970	COG1653	transport
BC6307_RS05985	COG1472	Belongs to the glycosyl hydrolase 3 family
BC6307_RS06005	COG4145	pantothenate transmembrane transporter activity
BC6307_RS06010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_RS06015	COG0473	3-isopropylmalate dehydrogenase activity
BC6307_RS06025	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_RS06030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BC6307_RS06035	COG1522	sequence-specific DNA binding
BC6307_RS06045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BC6307_RS06050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC6307_RS06055	COG0745	RESPONSE REGULATOR receiver
BC6307_RS06060	COG3850	Histidine kinase
BC6307_RS06060	COG5002	protein histidine kinase activity
BC6307_RS06065	COG1136	(ABC) transporter
BC6307_RS06075	COG0745	RESPONSE REGULATOR receiver
BC6307_RS06080	COG2205	protein histidine kinase activity
BC6307_RS06085	COG1136	(ABC) transporter
BC6307_RS06090	COG0577	efflux transmembrane transporter activity
BC6307_RS06105	COG1757	Na H antiporter
BC6307_RS06110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BC6307_RS06115	COG1126	abc transporter atp-binding protein
BC6307_RS06120	COG0765	amino acid transport
BC6307_RS06125	COG0765	amino acid transport
BC6307_RS06130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC6307_RS06135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BC6307_RS06150	COG2030	dehydratase
BC6307_RS06155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC6307_RS06205	COG0446	pyridine nucleotide-disulphide oxidoreductase
BC6307_RS06230	COG1136	(ABC) transporter
BC6307_RS06255	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS06260	COG0668	transmembrane transport
BC6307_RS06270	COG0477	Major facilitator Superfamily
BC6307_RS06305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BC6307_RS06310	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC6307_RS06320	COG4948	Mandelate Racemase Muconate Lactonizing
BC6307_RS06325	COG1288	antiporter activity
BC6307_RS06335	COG1473	amidohydrolase
BC6307_RS06350	COG1388	LysM domain
BC6307_RS06350	COG0791	NLP P60 protein
BC6307_RS06355	COG0745	RESPONSE REGULATOR receiver
BC6307_RS06360	COG5002	protein histidine kinase activity
BC6307_RS06360	COG3850	Histidine kinase
BC6307_RS06370	COG0577	efflux transmembrane transporter activity
BC6307_RS06375	COG1136	(ABC) transporter
BC6307_RS06380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_RS06390	COG0737	Belongs to the 5'-nucleotidase family
BC6307_RS06395	COG1191	sigma factor activity
BC6307_RS06415	COG1584	GPR1 FUN34 yaaH family protein
BC6307_RS06420	COG1657	PFAM Prenyltransferase squalene oxidase
BC6307_RS06445	COG2226	methyltransferase
BC6307_RS06455	COG2267	carboxylic ester hydrolase activity
BC6307_RS06475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BC6307_RS06485	COG1476	TRANSCRIPTIONal
BC6307_RS06490	COG2207	Transcriptional regulator
BC6307_RS06495	COG1472	Belongs to the glycosyl hydrolase 3 family
BC6307_RS06515	COG3314	Sporulation integral membrane protein YlbJ
BC6307_RS06525	COG0702	epimerase
BC6307_RS06540	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BC6307_RS06555	COG1115	amino acid carrier protein
BC6307_RS06560	COG1215	transferase activity, transferring glycosyl groups
BC6307_RS06565	COG1414	Transcriptional regulator
BC6307_RS06570	COG0531	amino acid
BC6307_RS06645	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BC6307_RS06660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BC6307_RS06665	COG0456	acetyltransferase
BC6307_RS06690	COG0745	RESPONSE REGULATOR receiver
BC6307_RS06705	COG2205	protein histidine kinase activity
BC6307_RS06745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC6307_RS06755	COG2814	Major facilitator Superfamily
BC6307_RS06760	COG0640	Transcriptional regulator
BC6307_RS06840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC6307_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS06870	COG4145	pantothenate transmembrane transporter activity
BC6307_RS06920	COG2197	response regulator
BC6307_RS06960	COG2200	EAL domain
BC6307_RS06970	COG3119	arylsulfatase activity
BC6307_RS06980	COG2746	aminoglycoside 3-N-acetyltransferase activity
BC6307_RS06990	COG0493	'glutamate synthase
BC6307_RS07045	COG2031	fatty acid transporter
BC6307_RS07050	COG2188	Transcriptional regulator
BC6307_RS07055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC6307_RS07060	COG1653	transport
BC6307_RS07065	COG1175	transmembrane transport
BC6307_RS07070	COG0395	ABC-type sugar transport system, permease component
BC6307_RS07075	COG1082	Xylose isomerase domain protein TIM barrel
BC6307_RS07080	COG2814	Major facilitator Superfamily
BC6307_RS07090	COG2222	sugar isomerase
BC6307_RS07095	COG0322	excinuclease ABC activity
BC6307_RS07120	COG1204	response to ionizing radiation
BC6307_RS07180	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BC6307_RS07190	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BC6307_RS07225	COG1401	restriction endodeoxyribonuclease activity
BC6307_RS07240	COG0494	nUDIX hydrolase
BC6307_RS07270	COG1401	restriction endodeoxyribonuclease activity
BC6307_RS07285	COG0583	DNA-binding transcription factor activity
BC6307_RS07290	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BC6307_RS07360	COG1192	Involved in chromosome partitioning
BC6307_RS07370	COG0561	phosphatase activity
BC6307_RS07385	COG1595	DNA-templated transcription, initiation
BC6307_RS07400	COG5646	InterPro IPR014922
BC6307_RS07405	COG2222	sugar isomerase
BC6307_RS07410	COG1653	transport
BC6307_RS07415	COG1175	transmembrane transport
BC6307_RS07420	COG0395	ABC-type sugar transport system, permease component
BC6307_RS07425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC6307_RS07430	COG2188	Transcriptional regulator
BC6307_RS07435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BC6307_RS07445	COG1404	Belongs to the peptidase S8 family
BC6307_RS07450	COG1595	DNA-templated transcription, initiation
BC6307_RS07465	COG1136	(ABC) transporter
BC6307_RS07480	COG0110	maltose O-acetyltransferase activity
BC6307_RS07490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BC6307_RS07525	COG0110	maltose O-acetyltransferase activity
BC6307_RS07550	COG2247	cell wall binding repeat
BC6307_RS07550	COG2385	sporulation resulting in formation of a cellular spore
BC6307_RS07570	COG0477	Major facilitator Superfamily
BC6307_RS07615	COG1280	lysine exporter protein (LysE YggA)
BC6307_RS07620	COG1378	Sugar-specific transcriptional regulator TrmB
BC6307_RS07650	COG5504	Zn-dependent protease
BC6307_RS07675	COG0454	-acetyltransferase
BC6307_RS07680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_RS07720	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BC6307_RS07725	COG3844	kynureninase activity
BC6307_RS07730	COG1309	transcriptional regulator
BC6307_RS07740	COG0494	nUDIX hydrolase
BC6307_RS07745	COG0494	nUDIX hydrolase
BC6307_RS07760	COG3615	Tellurite resistance protein tehB
BC6307_RS07760	COG0500	methyltransferase
BC6307_RS07765	COG0681	Belongs to the peptidase S26 family
BC6307_RS07785	COG0154	amidase activity
BC6307_RS07885	COG2267	carboxylic ester hydrolase activity
BC6307_RS07900	COG0488	(ABC) transporter
BC6307_RS07905	COG2746	aminoglycoside 3-N-acetyltransferase activity
BC6307_RS07920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BC6307_RS07955	COG1846	Transcriptional regulator
BC6307_RS07960	COG0456	acetyltransferase
BC6307_RS07965	COG2808	Putative FMN-binding domain
BC6307_RS07995	COG0202	RNA polymerase activity
BC6307_RS08035	COG1595	DNA-templated transcription, initiation
BC6307_RS08050	COG2226	methyltransferase
BC6307_RS08070	COG1063	alcohol dehydrogenase
BC6307_RS08100	COG1164	Oligoendopeptidase f
BC6307_RS08110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BC6307_RS08120	COG1595	DNA-templated transcription, initiation
BC6307_RS08135	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BC6307_RS08140	COG4978	Transcriptional regulator
BC6307_RS08140	COG0789	Transcriptional regulator
BC6307_RS08145	COG2814	Major facilitator Superfamily
BC6307_RS08200	COG1309	transcriptional regulator
BC6307_RS08215	COG0753	catalase activity
BC6307_RS08235	COG2323	membrane
BC6307_RS08240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_RS08255	COG1595	DNA-templated transcription, initiation
BC6307_RS08270	COG2226	methyltransferase
BC6307_RS08285	COG2213	PTS system mannitol-specific
BC6307_RS08285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC6307_RS08290	COG3711	transcriptional antiterminator
BC6307_RS08340	COG2135	peptidase activity
BC6307_RS08365	COG0778	Nitroreductase
BC6307_RS08370	COG0346	lactoylglutathione lyase activity
BC6307_RS08375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BC6307_RS08380	COG0346	lactoylglutathione lyase activity
BC6307_RS08385	COG0400	carboxylic ester hydrolase activity
BC6307_RS08390	COG2259	Doxx family
BC6307_RS08400	COG0662	Cupin 2, conserved barrel domain protein
BC6307_RS08405	COG0697	spore germination
BC6307_RS08410	COG1522	sequence-specific DNA binding
BC6307_RS08430	COG4149	molybdate abc transporter
BC6307_RS08435	COG1846	Transcriptional regulator
BC6307_RS08440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BC6307_RS08455	COG1714	RDD family
BC6307_RS08475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BC6307_RS08510	COG1595	DNA-templated transcription, initiation
BC6307_RS08540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_RS08550	COG4682	membrane
BC6307_RS08560	COG0697	spore germination
BC6307_RS08565	COG1917	Cupin 2, conserved barrel domain protein
BC6307_RS08565	COG2207	Transcriptional regulator
BC6307_RS08600	COG1051	belongs to the nudix hydrolase family
BC6307_RS08605	COG0596	Alpha beta hydrolase
BC6307_RS08650	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BC6307_RS08670	COG1131	(ABC) transporter
BC6307_RS08685	COG0714	Associated with various cellular activities
BC6307_RS08705	COG2364	Membrane
BC6307_RS08715	COG0114	fumarate hydratase activity
BC6307_RS08735	COG0435	Glutathione S-transferase
BC6307_RS08745	COG0300	oxidoreductase activity
BC6307_RS08750	COG3118	belongs to the thioredoxin family
BC6307_RS08765	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_RS08765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_RS08775	COG1405	negative regulation of cell septum assembly
BC6307_RS08775	COG3012	SEC-C Motif Domain Protein
BC6307_RS08780	COG0436	Aminotransferase
BC6307_RS08785	COG2329	Antibiotic biosynthesis monooxygenase
BC6307_RS08795	COG1929	Belongs to the glycerate kinase type-1 family
BC6307_RS08810	COG1271	oxidase subunit
BC6307_RS08815	COG1294	oxidase, subunit
BC6307_RS08820	COG4988	ABC transporter
BC6307_RS08825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BC6307_RS08830	COG2764	glyoxalase bleomycin resistance protein dioxygenase
BC6307_RS08845	COG1309	transcriptional regulator
BC6307_RS08850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BC6307_RS08855	COG1278	Cold shock
BC6307_RS08875	COG2188	Transcriptional regulator
BC6307_RS08880	COG1131	(ABC) transporter
BC6307_RS08885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_RS08910	COG1363	Peptidase, m42
BC6307_RS08915	COG1533	DNA photolyase activity
BC6307_RS08930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BC6307_RS08935	COG2224	Isocitrate lyase
BC6307_RS08950	COG2814	Major facilitator Superfamily
BC6307_RS08965	COG3584	3D domain protein
BC6307_RS08965	COG1388	LysM domain
BC6307_RS09005	COG0668	transmembrane transport
BC6307_RS09015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC6307_RS09030	COG3285	dna ligase
BC6307_RS09030	COG1793	dna ligase
BC6307_RS09035	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BC6307_RS09050	COG1191	sigma factor activity
BC6307_RS09065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BC6307_RS09070	COG2814	Major facilitator Superfamily
BC6307_RS09095	COG5002	protein histidine kinase activity
BC6307_RS09100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BC6307_RS09115	COG0640	Transcriptional regulator
BC6307_RS09120	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BC6307_RS09125	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BC6307_RS09130	COG1278	Cold shock
BC6307_RS09135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC6307_RS09140	COG0436	Aminotransferase
BC6307_RS09145	COG1850	ribulose-bisphosphate carboxylase activity
BC6307_RS09150	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BC6307_RS09155	COG0235	Class ii aldolase
BC6307_RS09160	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BC6307_RS09170	COG2861	carbohydrate metabolic process
BC6307_RS09190	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BC6307_RS09195	COG3639	organic phosphonate transmembrane transporter activity
BC6307_RS09200	COG3639	organic phosphonate transmembrane transporter activity
BC6307_RS09205	COG0737	Belongs to the 5'-nucleotidase family
BC6307_RS09210	COG1846	Transcriptional regulator
BC6307_RS09220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BC6307_RS09235	COG3949	Membrane
BC6307_RS09240	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC6307_RS09255	COG0720	synthase
BC6307_RS09265	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BC6307_RS09275	COG4873	Protein conserved in bacteria
BC6307_RS09320	COG1725	Transcriptional regulator
BC6307_RS09325	COG1131	(ABC) transporter
BC6307_RS09335	COG1131	(ABC) transporter
BC6307_RS09340	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BC6307_RS09345	COG1136	(ABC) transporter
BC6307_RS09350	COG0577	efflux transmembrane transporter activity
BC6307_RS09355	COG0726	polysaccharide deacetylase
BC6307_RS09375	COG0714	Associated with various cellular activities
BC6307_RS09410	COG3546	catalase activity
BC6307_RS09415	COG0791	NLP P60 protein
BC6307_RS09415	COG1388	LysM domain
BC6307_RS09450	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS09465	COG2986	histidine ammonia-lyase
BC6307_RS09470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BC6307_RS09480	COG0010	Belongs to the arginase family
BC6307_RS09485	COG3859	Proton-coupled thiamine transporter YuaJ
BC6307_RS09490	COG2084	Dehydrogenase
BC6307_RS09495	COG4191	Histidine kinase
BC6307_RS09500	COG0733	neurotransmitter:sodium symporter activity
BC6307_RS09510	COG0436	Aminotransferase
BC6307_RS09520	COG5582	Belongs to the UPF0302 family
BC6307_RS09530	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS09540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC6307_RS09545	COG3594	Acyltransferase
BC6307_RS09550	COG1607	acyl-coa hydrolase
BC6307_RS09560	COG1278	Cold shock
BC6307_RS09565	COG4191	Histidine kinase
BC6307_RS09570	COG1388	LysM domain
BC6307_RS09570	COG3584	3D domain protein
BC6307_RS09580	COG1404	Belongs to the peptidase S8 family
BC6307_RS09585	COG3620	sequence-specific DNA binding
BC6307_RS09600	COG0596	Alpha beta hydrolase
BC6307_RS09605	COG3011	Protein conserved in bacteria
BC6307_RS09610	COG5522	Integral membrane protein (intg_mem_TP0381)
BC6307_RS09620	COG1349	DNA-binding transcription factor activity
BC6307_RS09625	COG1105	Belongs to the carbohydrate kinase PfkB family
BC6307_RS09630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC6307_RS09630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC6307_RS09630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC6307_RS09640	COG3663	DNA glycosylase
BC6307_RS09650	COG0346	lactoylglutathione lyase activity
BC6307_RS09670	COG0714	Associated with various cellular activities
BC6307_RS09705	COG1842	Phage shock protein A
BC6307_RS09720	COG2197	response regulator
BC6307_RS09730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BC6307_RS09745	COG2873	o-acetylhomoserine
BC6307_RS09750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BC6307_RS09755	COG0326	Molecular chaperone. Has ATPase activity
BC6307_RS09770	COG4152	abc transporter atp-binding protein
BC6307_RS09775	COG2309	aminopeptidase activity
BC6307_RS09800	COG3858	chitin binding
BC6307_RS09800	COG1388	LysM domain
BC6307_RS09815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_RS09830	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BC6307_RS09840	COG0745	RESPONSE REGULATOR receiver
BC6307_RS09845	COG5002	protein histidine kinase activity
BC6307_RS09860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_RS09870	COG1686	Belongs to the peptidase S11 family
BC6307_RS09890	COG2190	(PTS) system
BC6307_RS09895	COG1263	PTS System
BC6307_RS09895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_RS09900	COG0366	Alpha amylase catalytic
BC6307_RS09910	COG0784	Response regulator, receiver
BC6307_RS09910	COG0835	chemotaxis
BC6307_RS09920	COG1408	metallophosphoesterase
BC6307_RS09925	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS09935	COG2200	EAL domain
BC6307_RS09950	COG4703	Protein of unknown function (DUF1797)
BC6307_RS09955	COG5506	Protein of unknown function (DUF1694)
BC6307_RS09965	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BC6307_RS09970	COG0517	IMP dehydrogenase activity
BC6307_RS09975	COG2814	Major facilitator Superfamily
BC6307_RS09990	COG0583	DNA-binding transcription factor activity
BC6307_RS10000	COG2171	N-acyltransferase activity
BC6307_RS10005	COG1473	amidohydrolase
BC6307_RS10015	COG0668	transmembrane transport
BC6307_RS10020	COG1132	(ABC) transporter
BC6307_RS10025	COG1132	(ABC) transporter
BC6307_RS10030	COG1199	ATP-dependent helicase activity
BC6307_RS10030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BC6307_RS10050	COG0436	Aminotransferase
BC6307_RS10055	COG0017	Asparaginyl-tRNA synthetase
BC6307_RS10060	COG3935	DnaD domain protein
BC6307_RS10065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BC6307_RS10075	COG4499	WXG100 protein secretion system (Wss), protein YukC
BC6307_RS10075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC6307_RS10080	COG3331	DNA recombination
BC6307_RS10125	COG0392	lysyltransferase activity
BC6307_RS10125	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BC6307_RS10130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BC6307_RS10135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BC6307_RS10140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BC6307_RS10145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BC6307_RS10150	COG0505	Belongs to the CarA family
BC6307_RS10160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BC6307_RS10165	COG0137	argininosuccinate synthase activity
BC6307_RS10170	COG0165	Argininosuccinate lyase
BC6307_RS10180	COG1737	Transcriptional regulator
BC6307_RS10185	COG2188	Transcriptional regulator
BC6307_RS10190	COG0363	glucosamine-6-phosphate deaminase activity
BC6307_RS10195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BC6307_RS10200	COG5609	conserved protein (DUF2294)
BC6307_RS10225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS10230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS10230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS10250	COG1205	dead DEAH box helicase
BC6307_RS10250	COG1111	helicase
BC6307_RS10255	COG3359	exonuclease
BC6307_RS10265	COG4474	Belongs to the UPF0398 family
BC6307_RS10280	COG0116	Belongs to the methyltransferase superfamily
BC6307_RS10295	COG1199	ATP-dependent helicase activity
BC6307_RS10300	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BC6307_RS10305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC6307_RS10310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BC6307_RS10335	COG3424	synthase
BC6307_RS10340	COG1755	Isoprenylcysteine carboxyl methyltransferase
BC6307_RS10345	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BC6307_RS10375	COG5658	integral membrane protein
BC6307_RS10385	COG1309	transcriptional regulator
BC6307_RS10390	COG1131	(ABC) transporter
BC6307_RS10395	COG3559	Exporter of polyketide antibiotics
BC6307_RS10410	COG0165	Argininosuccinate lyase
BC6307_RS10425	COG0395	ABC-type sugar transport system, permease component
BC6307_RS10430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BC6307_RS10435	COG3069	C4-dicarboxylate transmembrane transporter activity
BC6307_RS10445	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS10450	COG3711	transcriptional antiterminator
BC6307_RS10455	COG2190	(PTS) system
BC6307_RS10455	COG1263	PTS System
BC6307_RS10455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_RS10470	COG0346	lactoylglutathione lyase activity
BC6307_RS10475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC6307_RS10485	COG2357	RelA SpoT domain protein
BC6307_RS10510	COG0328	RNA-DNA hybrid ribonuclease activity
BC6307_RS10515	COG0328	RNA-DNA hybrid ribonuclease activity
BC6307_RS10530	COG1278	Cold shock
BC6307_RS10550	COG4974	Belongs to the 'phage' integrase family
BC6307_RS10570	COG1937	Protein conserved in bacteria
BC6307_RS10575	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_RS10585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS10590	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS10590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS10600	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_RS10605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS10605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS10610	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS10625	COG0288	reversible hydration of carbon dioxide
BC6307_RS10635	COG0726	polysaccharide deacetylase
BC6307_RS10640	COG1966	Carbon starvation protein
BC6307_RS10650	COG0517	IMP dehydrogenase activity
BC6307_RS10660	COG0697	spore germination
BC6307_RS10715	COG0517	IMP dehydrogenase activity
BC6307_RS10720	COG0662	Cupin 2, conserved barrel domain protein
BC6307_RS10730	COG1064	alcohol dehydrogenase
BC6307_RS10760	COG2226	methyltransferase
BC6307_RS10780	COG0584	glycerophosphoryl diester phosphodiesterase
BC6307_RS10795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_RS10805	COG2226	methyltransferase
BC6307_RS10825	COG1307	EDD domain protein, DegV family
BC6307_RS10835	COG1418	mRNA catabolic process
BC6307_RS10840	COG0488	(ABC) transporter
BC6307_RS10845	COG1413	lyase activity
BC6307_RS10855	COG2136	Putative SAM-dependent methyltransferase
BC6307_RS10855	COG2521	methyltransferase
BC6307_RS10875	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BC6307_RS10880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BC6307_RS10890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BC6307_RS10900	COG1307	EDD domain protein, DegV family
BC6307_RS10915	COG1999	signal sequence binding
BC6307_RS10920	COG2755	lipolytic protein G-D-S-L family
BC6307_RS10965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC6307_RS10965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC6307_RS10975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BC6307_RS10980	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BC6307_RS10985	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BC6307_RS10990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_RS10995	COG0456	acetyltransferase
BC6307_RS11000	COG3829	transcription factor binding
BC6307_RS11005	COG1509	lysine 2,3-aminomutase activity
BC6307_RS11015	COG4479	Belongs to the UPF0346 family
BC6307_RS11045	COG0813	purine-nucleoside phosphorylase activity
BC6307_RS11050	COG1876	peptidase activity
BC6307_RS11070	COG0400	carboxylic ester hydrolase activity
BC6307_RS11075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BC6307_RS11085	COG3396	Phenylacetate-CoA oxygenase
BC6307_RS11115	COG1024	Enoyl-CoA hydratase
BC6307_RS11120	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_RS11125	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC6307_RS11130	COG0183	Belongs to the thiolase family
BC6307_RS11135	COG3327	negative regulation of DNA-templated transcription, initiation
BC6307_RS11145	COG3344	reverse transcriptase
BC6307_RS11170	COG4120	Belongs to the binding-protein-dependent transport system permease family
BC6307_RS11175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC6307_RS11190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BC6307_RS11210	COG3185	4-Hydroxyphenylpyruvate dioxygenase
BC6307_RS11215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BC6307_RS11220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BC6307_RS11225	COG0179	Fumarylacetoacetate (FAA) hydrolase
BC6307_RS11235	COG2340	Cysteine-rich secretory protein family
BC6307_RS11245	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BC6307_RS11250	COG0534	Mate efflux family protein
BC6307_RS11255	COG0861	Integral membrane protein TerC family
BC6307_RS11260	COG0714	Associated with various cellular activities
BC6307_RS11265	COG4548	von Willebrand factor, type A
BC6307_RS11275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BC6307_RS11295	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_RS11305	COG3853	Toxic anion resistance protein (TelA)
BC6307_RS11325	COG3773	Cell wall hydrolase
BC6307_RS11330	COG2226	methyltransferase
BC6307_RS11340	COG0488	(ABC) transporter
BC6307_RS11355	COG1823	symporter activity
BC6307_RS11365	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_RS11370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BC6307_RS11375	COG0514	ATP-dependent DNA helicase (RecQ)
BC6307_RS11385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC6307_RS11390	COG2404	hydrolase activity, acting on ester bonds
BC6307_RS11395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BC6307_RS11400	COG2223	nitrite transmembrane transporter activity
BC6307_RS11410	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BC6307_RS11435	COG3546	catalase activity
BC6307_RS11445	COG2340	Cysteine-rich secretory protein family
BC6307_RS11460	COG4589	Belongs to the CDS family
BC6307_RS11470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BC6307_RS11480	COG0514	ATP-dependent DNA helicase (RecQ)
BC6307_RS11485	COG3610	response to peptide
BC6307_RS11490	COG2966	Psort location CytoplasmicMembrane, score
BC6307_RS11505	COG0768	penicillin binding
BC6307_RS11520	COG0542	response to heat
BC6307_RS11535	COG2323	membrane
BC6307_RS11550	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BC6307_RS11555	COG1733	regulation of RNA biosynthetic process
BC6307_RS11560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC6307_RS11560	COG3153	acetyltransferase
BC6307_RS11565	COG0456	acetyltransferase
BC6307_RS11575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC6307_RS11590	COG3621	Patatin-like phospholipase
BC6307_RS11605	COG0745	RESPONSE REGULATOR receiver
BC6307_RS11610	COG5002	protein histidine kinase activity
BC6307_RS11610	COG3850	Histidine kinase
BC6307_RS11620	COG3212	peptidase
BC6307_RS11625	COG1966	Carbon starvation protein
BC6307_RS11635	COG0003	Pfam Anion-transporting ATPase
BC6307_RS11640	COG3906	Belongs to the UPF0473 family
BC6307_RS11665	COG0697	spore germination
BC6307_RS11670	COG1054	Belongs to the UPF0176 family
BC6307_RS11675	COG0697	spore germination
BC6307_RS11680	COG0077	Prephenate dehydratase
BC6307_RS11685	COG3858	chitin binding
BC6307_RS11690	COG1404	Belongs to the peptidase S8 family
BC6307_RS11700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BC6307_RS11705	COG3739	integral membrane protein
BC6307_RS11710	COG3655	Transcriptional regulator
BC6307_RS11720	COG1247	-acetyltransferase
BC6307_RS11750	COG0346	lactoylglutathione lyase activity
BC6307_RS11755	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BC6307_RS11775	COG3340	Belongs to the peptidase S51 family
BC6307_RS11810	COG4473	ABC transporter
BC6307_RS11820	COG1271	oxidase subunit
BC6307_RS11825	COG1294	oxidase, subunit
BC6307_RS11830	COG4988	ABC transporter
BC6307_RS11835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BC6307_RS11840	COG1764	response to oxidative stress
BC6307_RS11870	COG0456	acetyltransferase
BC6307_RS11870	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BC6307_RS11915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC6307_RS11925	COG2385	sporulation resulting in formation of a cellular spore
BC6307_RS11945	COG2207	Transcriptional regulator
BC6307_RS11945	COG3708	Transcriptional regulator
BC6307_RS11960	COG1090	epimerase
BC6307_RS11965	COG0778	Nitroreductase
BC6307_RS12015	COG0671	phosphoesterase, PA-phosphatase related
BC6307_RS12020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BC6307_RS12025	COG0187	DNA topoisomerase II activity
BC6307_RS12030	COG1832	CoA-binding protein
BC6307_RS12035	COG3858	chitin binding
BC6307_RS12040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BC6307_RS12050	COG2843	Capsule synthesis protein
BC6307_RS12055	COG1051	belongs to the nudix hydrolase family
BC6307_RS12060	COG4841	protein insertion into membrane
BC6307_RS12070	COG0824	Thioesterase
BC6307_RS12090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_RS12095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BC6307_RS12125	COG1484	DNA-dependent DNA replication
BC6307_RS12135	COG4846	Membrane protein involved in cytochrome C biogenesis
BC6307_RS12140	COG2201	protein-glutamate methylesterase activity
BC6307_RS12145	COG0785	Cytochrome C biogenesis protein
BC6307_RS12155	COG1132	(ABC) transporter
BC6307_RS12160	COG1132	(ABC) transporter
BC6307_RS12165	COG3763	UPF0154 protein
BC6307_RS12180	COG4224	UPF0291 protein
BC6307_RS12185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BC6307_RS12200	COG0174	glutamine synthetase
BC6307_RS12205	COG0789	Transcriptional regulator
BC6307_RS12210	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BC6307_RS12215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BC6307_RS12220	COG2860	membrane
BC6307_RS12225	COG0464	growth
BC6307_RS12240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BC6307_RS12245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BC6307_RS12255	COG4550	Control of competence regulator ComK, YlbF/YmcA
BC6307_RS12260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BC6307_RS12265	COG1013	pyruvate-flavodoxin oxidoreductase activity
BC6307_RS12270	COG0674	pyruvate-flavodoxin oxidoreductase activity
BC6307_RS12270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BC6307_RS12280	COG2359	stage V sporulation protein S
BC6307_RS12285	COG1692	metallophosphoesterase
BC6307_RS12290	COG1418	mRNA catabolic process
BC6307_RS12295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BC6307_RS12300	COG1546	Belongs to the CinA family
BC6307_RS12300	COG1058	Belongs to the CinA family
BC6307_RS12305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BC6307_RS12310	COG1426	Protein conserved in bacteria
BC6307_RS12325	COG0300	oxidoreductase activity
BC6307_RS12330	COG0612	Peptidase, M16
BC6307_RS12335	COG0612	Peptidase, M16
BC6307_RS12340	COG2188	Transcriptional regulator
BC6307_RS12345	COG4980	gas vesicle protein
BC6307_RS12345	COG1674	ftsk spoiiie
BC6307_RS12355	COG0740	serine-type endopeptidase activity
BC6307_RS12360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BC6307_RS12365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC6307_RS12370	COG0527	aspartate kinase activity
BC6307_RS12375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BC6307_RS12380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BC6307_RS12385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC6307_RS12390	COG1873	PFAM PRC-barrel domain
BC6307_RS12395	COG0612	Peptidase, M16
BC6307_RS12400	COG0726	polysaccharide deacetylase
BC6307_RS12405	COG1185	polyribonucleotide nucleotidyltransferase activity
BC6307_RS12410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BC6307_RS12415	COG0196	riboflavin kinase activity
BC6307_RS12420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BC6307_RS12425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BC6307_RS12430	COG1550	Protein conserved in bacteria
BC6307_RS12440	COG1358	cellular component organization or biogenesis
BC6307_RS12445	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BC6307_RS12450	COG0195	Participates in both transcription termination and antitermination
BC6307_RS12455	COG0779	Required for maturation of 30S ribosomal subunits
BC6307_RS12460	COG2176	DNA-directed DNA polymerase activity
BC6307_RS12465	COG0750	zinc metalloprotease
BC6307_RS12470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BC6307_RS12475	COG4589	Belongs to the CDS family
BC6307_RS12480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BC6307_RS12500	COG0052	Belongs to the universal ribosomal protein uS2 family
BC6307_RS12515	COG1191	sigma factor activity
BC6307_RS12520	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BC6307_RS12525	COG1776	CheC inhibitor of MCP methylation
BC6307_RS12530	COG0835	chemotaxis
BC6307_RS12535	COG2198	Histidine kinase
BC6307_RS12535	COG0643	Histidine kinase
BC6307_RS12540	COG2201	protein-glutamate methylesterase activity
BC6307_RS12545	COG0455	bacterial-type flagellum organization
BC6307_RS12550	COG1419	protein localization to endoplasmic reticulum
BC6307_RS12555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BC6307_RS12560	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BC6307_RS12565	COG1684	flagellar biosynthetic protein fliR
BC6307_RS12570	COG1987	bacterial-type flagellum assembly
BC6307_RS12575	COG1338	Plays a role in the flagellum-specific transport system
BC6307_RS12580	COG3190	flagellar
BC6307_RS12585	COG2201	protein-glutamate methylesterase activity
BC6307_RS12590	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BC6307_RS12590	COG1776	CheC inhibitor of MCP methylation
BC6307_RS12595	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BC6307_RS12600	COG1580	Controls the rotational direction of flagella during chemotaxis
BC6307_RS12605	COG1582	Flagellar protein (FlbD)
BC6307_RS12610	COG4786	Flagellar basal body rod
BC6307_RS12615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BC6307_RS12620	COG3144	bacterial-type flagellum assembly
BC6307_RS12635	COG1157	protein secretion by the type III secretion system
BC6307_RS12640	COG1317	bacterial-type flagellum organization
BC6307_RS12645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BC6307_RS12650	COG1766	The M ring may be actively involved in energy transduction
BC6307_RS12655	COG1677	Flagellar hook-basal body complex protein FliE
BC6307_RS12660	COG1558	bacterial-type flagellum-dependent cell motility
BC6307_RS12665	COG1815	bacterial-type flagellum-dependent cell motility
BC6307_RS12670	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BC6307_RS12675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BC6307_RS12680	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BC6307_RS12685	COG4974	Belongs to the 'phage' integrase family
BC6307_RS12690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC6307_RS12695	COG0758	DNA mediated transformation
BC6307_RS12700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BC6307_RS12705	COG0045	succinate-CoA ligase (ADP-forming) activity
BC6307_RS12710	COG2257	FlhB HrpN YscU SpaS Family
BC6307_RS12725	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BC6307_RS12745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BC6307_RS12750	COG1837	Belongs to the UPF0109 family
BC6307_RS12760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BC6307_RS12765	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BC6307_RS12770	COG0552	protein localization to endoplasmic reticulum
BC6307_RS12775	COG1196	nuclear chromosome segregation
BC6307_RS12780	COG0571	ribonuclease III activity
BC6307_RS12785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC6307_RS12790	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS12795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BC6307_RS12800	COG0416	fatty acid biosynthetic process
BC6307_RS12810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BC6307_RS12815	COG1760	l-serine dehydratase
BC6307_RS12820	COG1760	l-serine dehydratase
BC6307_RS12825	COG1461	Dihydroxyacetone kinase
BC6307_RS12830	COG1302	Protein conserved in bacteria
BC6307_RS12835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BC6307_RS12845	COG1564	THIamine pyrophosphokinase
BC6307_RS12850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BC6307_RS12855	COG1162	GTPase activity
BC6307_RS12860	COG0515	serine threonine protein kinase
BC6307_RS12860	COG2815	serine threonine protein kinase
BC6307_RS12865	COG0631	protein serine/threonine phosphatase activity
BC6307_RS12870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BC6307_RS12875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BC6307_RS12875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC6307_RS12880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BC6307_RS12890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BC6307_RS12895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BC6307_RS12900	COG1758	RNA polymerase activity
BC6307_RS12905	COG0194	GDP metabolic process
BC6307_RS12910	COG2052	Domain of unknown function (DUF370)
BC6307_RS12915	COG1561	YicC-like family, N-terminal region
BC6307_RS12920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC6307_RS12925	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BC6307_RS12930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BC6307_RS12935	COG0284	orotidine-5'-phosphate decarboxylase activity
BC6307_RS12940	COG0167	dihydroorotate dehydrogenase activity
BC6307_RS12945	COG0543	2 iron, 2 sulfur cluster binding
BC6307_RS12950	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BC6307_RS12955	COG0505	Belongs to the CarA family
BC6307_RS12960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BC6307_RS12965	COG0540	Belongs to the ATCase OTCase family
BC6307_RS12970	COG2233	PERMEase
BC6307_RS12975	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BC6307_RS12980	COG0564	pseudouridine synthase activity
BC6307_RS12990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BC6307_RS12995	COG3599	regulation of cell shape
BC6307_RS13000	COG2302	S4 RNA-binding domain
BC6307_RS13005	COG0762	integral membrane protein
BC6307_RS13010	COG1799	cell septum assembly
BC6307_RS13015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BC6307_RS13020	COG1496	oxidoreductase activity
BC6307_RS13025	COG1873	PFAM PRC-barrel domain
BC6307_RS13035	COG1191	sigma factor activity
BC6307_RS13040	COG1191	sigma factor activity
BC6307_RS13050	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BC6307_RS13055	COG0849	cell division
BC6307_RS13060	COG3856	small basic protein
BC6307_RS13065	COG3879	Bacterial protein of unknown function (DUF881)
BC6307_RS13070	COG3879	Bacterial protein of unknown function (DUF881)
BC6307_RS13075	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BC6307_RS13080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BC6307_RS13085	COG0772	Belongs to the SEDS family
BC6307_RS13095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BC6307_RS13105	COG0768	penicillin binding
BC6307_RS13110	COG0768	penicillin binding
BC6307_RS13115	COG4839	cell division protein FtsL
BC6307_RS13120	COG0275	rRNA processing
BC6307_RS13125	COG2001	Belongs to the MraZ family
BC6307_RS13130	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BC6307_RS13140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BC6307_RS13145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BC6307_RS13150	COG0511	ligase activity, forming carbon-carbon bonds
BC6307_RS13155	COG0439	Biotin carboxylase
BC6307_RS13160	COG0454	-acetyltransferase
BC6307_RS13170	COG1024	Enoyl-CoA hydratase
BC6307_RS13175	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BC6307_RS13180	COG1399	metal-binding, possibly nucleic acid-binding protein
BC6307_RS13185	COG1323	Belongs to the UPF0348 family
BC6307_RS13190	COG3480	Lon protease (S16) C-terminal proteolytic domain
BC6307_RS13195	COG1752	Esterase of the alpha-beta hydrolase superfamily
BC6307_RS13200	COG3314	Sporulation integral membrane protein YlbJ
BC6307_RS13205	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BC6307_RS13210	COG0742	ribosomal rna small subunit methyltransferase
BC6307_RS13230	COG3679	Belongs to the UPF0342 family
BC6307_RS13260	COG2340	Cysteine-rich secretory protein family
BC6307_RS13265	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BC6307_RS13270	COG2340	Cysteine-rich secretory protein family
BC6307_RS13280	COG0628	permease
BC6307_RS13290	COG3336	cytochrome c oxidase
BC6307_RS13315	COG0109	protoheme IX farnesyltransferase activity
BC6307_RS13320	COG1612	heme a metabolic process
BC6307_RS13325	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BC6307_RS13330	COG4838	Belongs to the UPF0358 family
BC6307_RS13335	COG2066	Belongs to the glutaminase family
BC6307_RS13340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BC6307_RS13345	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BC6307_RS13355	COG4896	Protein conserved in bacteria
BC6307_RS13370	COG1217	gtp-binding protein TYPA
BC6307_RS13380	COG0483	inositol monophosphate 1-phosphatase activity
BC6307_RS13390	COG4493	Belongs to the UPF0637 family
BC6307_RS13395	COG4476	Belongs to the UPF0223 family
BC6307_RS13405	COG1982	Orn Lys Arg decarboxylase major
BC6307_RS13415	COG1846	Transcriptional regulator
BC6307_RS13420	COG0386	Belongs to the glutathione peroxidase family
BC6307_RS13445	COG0508	dehydrogenase complex catalyzes the overall conversion of
BC6307_RS13450	COG0022	dehydrogenase e1 component
BC6307_RS13470	COG5503	Protein of unknown function (DUF1447)
BC6307_RS13475	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BC6307_RS13480	COG0569	domain protein
BC6307_RS13485	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BC6307_RS13510	COG0438	transferase activity, transferring glycosyl groups
BC6307_RS13515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BC6307_RS13520	COG1803	Methylglyoxal synthase
BC6307_RS13525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BC6307_RS13530	COG1694	Mazg nucleotide pyrophosphohydrolase
BC6307_RS13535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC6307_RS13540	COG2738	Putative neutral zinc metallopeptidase
BC6307_RS13550	COG4347	Protein of unknown function (DUF1405)
BC6307_RS13560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BC6307_RS13575	COG5582	Belongs to the UPF0302 family
BC6307_RS13580	COG0457	Tetratricopeptide repeat
BC6307_RS13590	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BC6307_RS13595	COG0287	Prephenate dehydrogenase
BC6307_RS13600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BC6307_RS13605	COG0159	tryptophan synthase activity
BC6307_RS13610	COG0133	tryptophan synthase activity
BC6307_RS13615	COG0135	phosphoribosylanthranilate isomerase activity
BC6307_RS13620	COG0134	indole-3-glycerol-phosphate synthase activity
BC6307_RS13625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BC6307_RS13630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BC6307_RS13635	COG4401	Chorismate mutase type I
BC6307_RS13640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BC6307_RS13645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BC6307_RS13650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BC6307_RS13655	COG0105	UTP biosynthetic process
BC6307_RS13660	COG0142	geranyltranstransferase activity
BC6307_RS13665	COG2226	methyltransferase
BC6307_RS13670	COG0142	geranyltranstransferase activity
BC6307_RS13680	COG0302	gtp cyclohydrolase
BC6307_RS13685	COG0776	regulation of translation
BC6307_RS13690	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BC6307_RS13710	COG1160	GTP binding
BC6307_RS13735	COG1304	FMN binding
BC6307_RS13740	COG0539	negative regulation of cytoplasmic translation
BC6307_RS13745	COG0204	Acyl-transferase
BC6307_RS13765	COG2959	enzyme of heme biosynthesis
BC6307_RS13770	COG3409	Peptidoglycan-binding domain 1 protein
BC6307_RS13770	COG3773	Cell wall hydrolase
BC6307_RS13775	COG2339	peptidase activity
BC6307_RS13785	COG0492	ferredoxin-NADP+ reductase activity
BC6307_RS13790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BC6307_RS13795	COG4862	establishment of competence for transformation
BC6307_RS13800	COG1408	metallophosphoesterase
BC6307_RS13815	COG1388	LysM domain
BC6307_RS13820	COG1266	CAAX protease self-immunity
BC6307_RS13825	COG0514	ATP-dependent DNA helicase (RecQ)
BC6307_RS13830	COG4955	Helix-turn-helix domain
BC6307_RS13835	COG1141	Ferredoxin
BC6307_RS13840	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BC6307_RS13855	COG1595	DNA-templated transcription, initiation
BC6307_RS13870	COG5002	protein histidine kinase activity
BC6307_RS13875	COG0745	RESPONSE REGULATOR receiver
BC6307_RS13880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BC6307_RS13885	COG1333	cytochrome c biogenesis protein
BC6307_RS13890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_RS13895	COG1187	pseudouridine synthase activity
BC6307_RS13900	COG0700	Nucleoside recognition
BC6307_RS13905	COG2715	membrane protein required for spore maturation
BC6307_RS13910	COG1686	Belongs to the peptidase S11 family
BC6307_RS13915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BC6307_RS13935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BC6307_RS13940	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BC6307_RS13945	COG1547	Domain of unknown function (DUF309)
BC6307_RS13955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BC6307_RS13960	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_RS13960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_RS13965	COG0307	riboflavin synthase, alpha
BC6307_RS13970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BC6307_RS13970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BC6307_RS13975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BC6307_RS13990	COG0697	spore germination
BC6307_RS14005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC6307_RS14030	COG2172	sigma factor antagonist activity
BC6307_RS14040	COG1686	Belongs to the peptidase S11 family
BC6307_RS14060	COG4974	Belongs to the 'phage' integrase family
BC6307_RS14070	COG0735	belongs to the Fur family
BC6307_RS14075	COG1300	Membrane
BC6307_RS14085	COG1379	DNA repair
BC6307_RS14090	COG0494	nUDIX hydrolase
BC6307_RS14100	COG0667	Aldo Keto reductase
BC6307_RS14110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BC6307_RS14115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BC6307_RS14120	COG0183	Belongs to the thiolase family
BC6307_RS14125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BC6307_RS14130	COG1073	alpha beta
BC6307_RS14145	COG0494	nUDIX hydrolase
BC6307_RS14150	COG2223	nitrite transmembrane transporter activity
BC6307_RS14155	COG1882	Formate acetyltransferase
BC6307_RS14160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BC6307_RS14170	COG2076	Multidrug Resistance protein
BC6307_RS14175	COG2076	Multidrug Resistance protein
BC6307_RS14205	COG1595	DNA-templated transcription, initiation
BC6307_RS14235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BC6307_RS14260	COG0300	oxidoreductase activity
BC6307_RS14265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS14270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BC6307_RS14290	COG1131	(ABC) transporter
BC6307_RS14305	COG1051	belongs to the nudix hydrolase family
BC6307_RS14330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BC6307_RS14350	COG2824	Alkylphosphonate utilization operon protein PhnA
BC6307_RS14375	COG1247	-acetyltransferase
BC6307_RS14385	COG2385	sporulation resulting in formation of a cellular spore
BC6307_RS14385	COG2247	cell wall binding repeat
BC6307_RS14390	COG4187	Peptidase family M20/M25/M40
BC6307_RS14395	COG1902	pentaerythritol trinitrate reductase activity
BC6307_RS14405	COG0346	lactoylglutathione lyase activity
BC6307_RS14410	COG0681	Belongs to the peptidase S26 family
BC6307_RS14430	COG1131	(ABC) transporter
BC6307_RS14440	COG2197	response regulator
BC6307_RS14445	COG4585	Histidine kinase
BC6307_RS14450	COG1234	tRNA 3'-trailer cleavage
BC6307_RS14460	COG0546	phosphoglycolate phosphatase activity
BC6307_RS14475	COG1556	Lactate utilization protein
BC6307_RS14480	COG1139	Iron-sulfur cluster binding protein
BC6307_RS14485	COG0247	lactate metabolic process
BC6307_RS14490	COG0277	FAD linked oxidase domain protein
BC6307_RS14495	COG0247	lactate metabolic process
BC6307_RS14510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BC6307_RS14520	COG2195	Cleaves the N-terminal amino acid of tripeptides
BC6307_RS14525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BC6307_RS14530	COG0346	lactoylglutathione lyase activity
BC6307_RS14545	COG1376	ErfK ybiS ycfS ynhG family protein
BC6307_RS14550	COG4129	membrane
BC6307_RS14555	COG1164	Oligoendopeptidase f
BC6307_RS14565	COG1703	isobutyryl-CoA mutase activity
BC6307_RS14570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC6307_RS14570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC6307_RS14575	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC6307_RS14585	COG0508	dehydrogenase complex catalyzes the overall conversion of
BC6307_RS14590	COG0022	dehydrogenase e1 component
BC6307_RS14595	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BC6307_RS14600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BC6307_RS14615	COG0280	phosphate acetyltransferase
BC6307_RS14620	COG3829	transcription factor binding
BC6307_RS14620	COG3290	protein histidine kinase activity
BC6307_RS14630	COG0584	glycerophosphoryl diester phosphodiesterase
BC6307_RS14635	COG3093	addiction module antidote protein HigA
BC6307_RS14640	COG0745	RESPONSE REGULATOR receiver
BC6307_RS14645	COG0750	zinc metalloprotease
BC6307_RS14650	COG0497	DNA recombination
BC6307_RS14655	COG1438	arginine binding
BC6307_RS14660	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BC6307_RS14665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BC6307_RS14685	COG1570	exodeoxyribonuclease VII activity
BC6307_RS14690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BC6307_RS14695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC6307_RS14700	COG1302	Protein conserved in bacteria
BC6307_RS14705	COG0439	Biotin carboxylase
BC6307_RS14710	COG0511	ligase activity, forming carbon-carbon bonds
BC6307_RS14750	COG3854	ATPases associated with a variety of cellular activities
BC6307_RS14765	COG1131	(ABC) transporter
BC6307_RS14775	COG0366	Alpha amylase catalytic
BC6307_RS14785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BC6307_RS14790	COG0006	proline dipeptidase activity
BC6307_RS14795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BC6307_RS14810	COG1752	Esterase of the alpha-beta hydrolase superfamily
BC6307_RS14840	COG2318	DinB family
BC6307_RS14845	COG0697	spore germination
BC6307_RS14850	COG0531	amino acid
BC6307_RS14865	COG1309	transcriptional regulator
BC6307_RS14880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC6307_RS14890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS14910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BC6307_RS14915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BC6307_RS14920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BC6307_RS14940	COG3275	phosphorelay sensor kinase activity
BC6307_RS14950	COG1966	Carbon starvation protein
BC6307_RS14965	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_RS14970	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS14995	COG1272	protein, Hemolysin III
BC6307_RS15015	COG0793	Belongs to the peptidase S41A family
BC6307_RS15020	COG0456	acetyltransferase
BC6307_RS15060	COG2318	DinB family
BC6307_RS15065	COG2333	competence protein COMEC
BC6307_RS15065	COG0658	competence protein
BC6307_RS15080	COG1376	ErfK ybiS ycfS ynhG family protein
BC6307_RS15090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BC6307_RS15095	COG0697	spore germination
BC6307_RS15100	COG0592	DNA-directed DNA polymerase activity
BC6307_RS15115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BC6307_RS15120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC6307_RS15150	COG4970	Tfp pilus assembly protein FimT
BC6307_RS15155	COG4537	Required for transformation and DNA binding
BC6307_RS15160	COG1459	type II secretion system
BC6307_RS15165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BC6307_RS15170	COG4191	Histidine kinase
BC6307_RS15200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS15215	COG0011	TIGRFAM Protein of
BC6307_RS15230	COG1368	sulfuric ester hydrolase activity
BC6307_RS15235	COG1940	carbohydrate kinase activity
BC6307_RS15245	COG0697	spore germination
BC6307_RS15255	COG0705	Rhomboid family
BC6307_RS15255	COG0457	Tetratricopeptide repeat
BC6307_RS15275	COG0039	L-malate dehydrogenase activity
BC6307_RS15285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BC6307_RS15315	COG1172	Belongs to the binding-protein-dependent transport system permease family
BC6307_RS15320	COG1129	ABC transporter
BC6307_RS15335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC6307_RS15340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BC6307_RS15345	COG0640	Transcriptional regulator
BC6307_RS15350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BC6307_RS15355	COG0659	secondary active sulfate transmembrane transporter activity
BC6307_RS15360	COG0704	Plays a role in the regulation of phosphate uptake
BC6307_RS15365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC6307_RS15370	COG0581	inorganic phosphate transmembrane transporter activity
BC6307_RS15375	COG0573	inorganic phosphate transmembrane transporter activity
BC6307_RS15380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BC6307_RS15385	COG0768	penicillin binding
BC6307_RS15390	COG0477	Major facilitator Superfamily
BC6307_RS15400	COG0205	6-phosphofructokinase activity
BC6307_RS15405	COG1320	monovalent cation:proton antiporter activity
BC6307_RS15410	COG2212	antiporter activity
BC6307_RS15415	COG1863	multisubunit Na H antiporter MnhE subunit
BC6307_RS15420	COG0651	ATP synthesis coupled electron transport
BC6307_RS15425	COG1006	Multisubunit Na H antiporter MnhC subunit
BC6307_RS15430	COG2111	Na H antiporter
BC6307_RS15435	COG2111	Na H antiporter
BC6307_RS15435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BC6307_RS15445	COG0582	viral genome integration into host DNA
BC6307_RS15450	COG0628	permease
BC6307_RS15470	COG2839	Protein conserved in bacteria
BC6307_RS15475	COG1283	sodium-dependent phosphate transmembrane transporter activity
BC6307_RS15480	COG5521	maltodextrose utilization protein MalA
BC6307_RS15490	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BC6307_RS15495	COG4709	membrane
BC6307_RS15500	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BC6307_RS15505	COG0735	belongs to the Fur family
BC6307_RS15510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC6307_RS15515	COG1121	(ABC) transporter
BC6307_RS15520	COG4191	Histidine kinase
BC6307_RS15530	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BC6307_RS15545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BC6307_RS15550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BC6307_RS15555	COG2384	SAM-dependent methyltransferase
BC6307_RS15560	COG2010	Cytochrome c
BC6307_RS15565	COG1960	acyl-CoA dehydrogenase activity
BC6307_RS15575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BC6307_RS15580	COG0358	DNA primase activity
BC6307_RS15585	COG1671	Belongs to the UPF0178 family
BC6307_RS15590	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BC6307_RS15595	COG0517	IMP dehydrogenase activity
BC6307_RS15600	COG0751	glycine-tRNA ligase activity
BC6307_RS15610	COG1381	Involved in DNA repair and RecF pathway recombination
BC6307_RS15620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BC6307_RS15625	COG0295	cytidine deaminase activity
BC6307_RS15630	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BC6307_RS15640	COG1480	7TM receptor with intracellular HD hydrolase
BC6307_RS15645	COG1702	phosphate starvation-inducible protein PhoH
BC6307_RS15660	COG0494	nUDIX hydrolase
BC6307_RS15670	COG4864	UPF0365 protein
BC6307_RS15675	COG1030	water channel activity
BC6307_RS15680	COG1610	YqeY-like protein
BC6307_RS15695	COG1283	sodium-dependent phosphate transmembrane transporter activity
BC6307_RS15700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BC6307_RS15715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BC6307_RS15720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BC6307_RS15725	COG2264	protein methyltransferase activity
BC6307_RS15735	COG0443	Heat shock 70 kDa protein
BC6307_RS15745	COG1420	regulation of RNA biosynthetic process
BC6307_RS15750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BC6307_RS15770	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC6307_RS15785	COG1466	dna polymerase III delta subunit
BC6307_RS15795	COG0658	competence protein
BC6307_RS15795	COG2333	competence protein COMEC
BC6307_RS15800	COG2131	deaminase
BC6307_RS15805	COG1596	polysaccharide export
BC6307_RS15805	COG1555	photosystem II stabilization
BC6307_RS15810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BC6307_RS15815	COG2226	methyltransferase
BC6307_RS15820	COG0799	negative regulation of ribosome biogenesis
BC6307_RS15825	COG1713	HD superfamily hydrolase involved in NAD metabolism
BC6307_RS15830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BC6307_RS15835	COG1534	Rna-binding protein
BC6307_RS15845	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BC6307_RS15850	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BC6307_RS15860	COG0688	phosphatidylethanolamine metabolic process
BC6307_RS15885	COG1525	nuclease
BC6307_RS15910	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BC6307_RS15915	COG1595	DNA-templated transcription, initiation
BC6307_RS15925	COG0626	cystathionine gamma-synthase activity
BC6307_RS15930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC6307_RS15935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BC6307_RS15940	COG2226	methyltransferase
BC6307_RS15955	COG0768	penicillin binding
BC6307_RS15960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BC6307_RS15965	COG0572	uridine kinase
BC6307_RS15970	COG0826	peptidase U32
BC6307_RS15975	COG0826	peptidase U32
BC6307_RS15980	COG4122	O-methyltransferase activity
BC6307_RS15985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BC6307_RS15990	COG3906	Belongs to the UPF0473 family
BC6307_RS15995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BC6307_RS16015	COG0628	permease
BC6307_RS16020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BC6307_RS16040	COG3881	PFAM PRC-barrel domain
BC6307_RS16045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BC6307_RS16050	COG0457	Tetratricopeptide repeat
BC6307_RS16055	COG0482	sulfurtransferase activity
BC6307_RS16060	COG1104	cysteine desulfurase activity
BC6307_RS16065	COG1959	2 iron, 2 sulfur cluster binding
BC6307_RS16070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BC6307_RS16075	COG0018	arginyl-trna synthetase
BC6307_RS16085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BC6307_RS16090	COG0346	lactoylglutathione lyase activity
BC6307_RS16100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BC6307_RS16105	COG0124	histidyl-tRNA synthetase
BC6307_RS16115	COG3103	Sh3 type 3 domain protein
BC6307_RS16115	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC6307_RS16115	COG4991	sh3 domain protein
BC6307_RS16120	COG1490	D-aminoacyl-tRNA deacylase activity
BC6307_RS16125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BC6307_RS16130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC6307_RS16135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BC6307_RS16135	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BC6307_RS16140	COG5416	Lipopolysaccharide assembly protein A domain
BC6307_RS16145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BC6307_RS16150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BC6307_RS16150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BC6307_RS16160	COG2244	polysaccharide biosynthetic process
BC6307_RS16165	COG2323	membrane
BC6307_RS16175	COG1862	Preprotein translocase
BC6307_RS16185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BC6307_RS16195	COG2255	four-way junction helicase activity
BC6307_RS16200	COG0632	four-way junction helicase activity
BC6307_RS16215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BC6307_RS16225	COG1388	LysM domain
BC6307_RS16235	COG0157	Belongs to the NadC ModD family
BC6307_RS16240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BC6307_RS16245	COG1104	cysteine desulfurase activity
BC6307_RS16250	COG1827	regulation of RNA biosynthetic process
BC6307_RS16255	COG0366	Alpha amylase catalytic
BC6307_RS16260	COG4492	Belongs to the UPF0735 family
BC6307_RS16270	COG3290	protein histidine kinase activity
BC6307_RS16280	COG2868	ribosomal protein
BC6307_RS16285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BC6307_RS16290	COG1530	ribonuclease E activity
BC6307_RS16295	COG1994	Peptidase M50
BC6307_RS16300	COG0739	heme binding
BC6307_RS16305	COG2894	cell division
BC6307_RS16310	COG0850	regulation of cytokinetic process
BC6307_RS16315	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BC6307_RS16320	COG1792	Involved in formation and maintenance of cell shape
BC6307_RS16325	COG1077	Cell shape determining protein MreB Mrl
BC6307_RS16330	COG2003	Belongs to the UPF0758 family
BC6307_RS16360	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BC6307_RS16370	COG1459	type II secretion system
BC6307_RS16380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BC6307_RS16405	COG3706	GGDEF domain
BC6307_RS16410	COG0285	dihydrofolate synthase activity
BC6307_RS16415	COG0525	valine-tRNA ligase activity
BC6307_RS16430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BC6307_RS16435	COG1388	LysM domain
BC6307_RS16435	COG1388	LysM domain
BC6307_RS16445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BC6307_RS16450	COG0113	porphobilinogen synthase activity
BC6307_RS16455	COG1587	Uroporphyrinogen-III synthase
BC6307_RS16460	COG0181	hydroxymethylbilane synthase activity
BC6307_RS16465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BC6307_RS16485	COG0765	amino acid transport
BC6307_RS16495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BC6307_RS16500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BC6307_RS16505	COG1067	ATP-dependent peptidase activity
BC6307_RS16505	COG0470	DNA polymerase III
BC6307_RS16510	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BC6307_RS16515	COG0544	peptidyl-prolyl cis-trans isomerase activity
BC6307_RS16520	COG0457	Tetratricopeptide repeat
BC6307_RS16520	COG1477	protein flavinylation
BC6307_RS16530	COG0622	Phosphoesterase
BC6307_RS16535	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BC6307_RS16545	COG5401	PFAM Sporulation and spore germination
BC6307_RS16555	COG1846	Transcriptional regulator
BC6307_RS16560	COG2197	response regulator
BC6307_RS16565	COG0824	Thioesterase
BC6307_RS16570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BC6307_RS16575	COG1053	succinate dehydrogenase
BC6307_RS16580	COG2009	succinate dehydrogenase
BC6307_RS16585	COG1719	4-vinyl reductase, 4VR
BC6307_RS16595	COG0322	excinuclease ABC activity
BC6307_RS16600	COG3118	belongs to the thioredoxin family
BC6307_RS16605	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BC6307_RS16610	COG2086	electron transfer activity
BC6307_RS16615	COG1024	Enoyl-CoA hydratase
BC6307_RS16620	COG1309	transcriptional regulator
BC6307_RS16625	COG0318	PFAM AMP-dependent synthetase and ligase
BC6307_RS16635	COG3766	membrane
BC6307_RS16640	COG1193	negative regulation of DNA recombination
BC6307_RS16645	COG1796	DNA polymerase
BC6307_RS16645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BC6307_RS16650	COG1286	toxin biosynthetic process
BC6307_RS16655	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BC6307_RS16660	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BC6307_RS16675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC6307_RS16675	COG0072	phenylalanine-tRNA ligase activity
BC6307_RS16680	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BC6307_RS16695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC6307_RS16705	COG1363	Peptidase, m42
BC6307_RS16730	COG0398	Pfam SNARE associated Golgi protein
BC6307_RS16735	COG3326	Membrane
BC6307_RS16740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BC6307_RS16745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BC6307_RS16750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BC6307_RS16755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BC6307_RS16765	COG3611	Membrane attachment protein
BC6307_RS16770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BC6307_RS16780	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BC6307_RS16785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BC6307_RS16795	COG1971	Probably functions as a manganese efflux pump
BC6307_RS16800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BC6307_RS16805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC6307_RS16805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC6307_RS16810	COG0330	HflC and HflK could
BC6307_RS16815	COG0330	HflC and HflK could
BC6307_RS16820	COG5002	protein histidine kinase activity
BC6307_RS16825	COG0745	RESPONSE REGULATOR receiver
BC6307_RS16835	COG0039	L-malate dehydrogenase activity
BC6307_RS16840	COG0538	isocitrate dehydrogenase activity
BC6307_RS16845	COG0372	Belongs to the citrate synthase family
BC6307_RS16850	COG2707	UPF0756 membrane protein
BC6307_RS16855	COG0628	permease
BC6307_RS16860	COG3030	protein affecting phage T7 exclusion by the F plasmid
BC6307_RS16870	COG0205	6-phosphofructokinase activity
BC6307_RS16875	COG0825	malonyl-CoA metabolic process
BC6307_RS16885	COG1725	Transcriptional regulator
BC6307_RS16890	COG0281	malic enzyme
BC6307_RS16895	COG0587	DNA-directed DNA polymerase activity
BC6307_RS16910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BC6307_RS16920	COG4109	DRTGG domain
BC6307_RS16930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BC6307_RS16935	COG0006	proline dipeptidase activity
BC6307_RS16940	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS16945	COG0589	response to stress
BC6307_RS16965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BC6307_RS16970	COG0827	DNA restriction-modification system
BC6307_RS16975	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BC6307_RS16980	COG3874	Sporulation protein YtfJ
BC6307_RS16990	COG1714	RDD family
BC6307_RS16995	COG0616	signal peptide processing
BC6307_RS17000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BC6307_RS17005	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BC6307_RS17015	COG0301	tRNA thio-modification
BC6307_RS17020	COG1104	cysteine desulfurase activity
BC6307_RS17025	COG1114	Component of the transport system for branched-chain amino acids
BC6307_RS17030	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BC6307_RS17035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BC6307_RS17040	COG1309	transcriptional regulator
BC6307_RS17045	COG1956	GAF domain-containing protein
BC6307_RS17050	COG0626	cystathionine gamma-synthase activity
BC6307_RS17055	COG2199	diguanylate cyclase activity
BC6307_RS17055	COG2203	Gaf domain
BC6307_RS17065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BC6307_RS17070	COG2207	Transcriptional regulator
BC6307_RS17075	COG2190	(PTS) system
BC6307_RS17075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_RS17075	COG1263	PTS System
BC6307_RS17095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC6307_RS17100	COG0454	-acetyltransferase
BC6307_RS17105	COG0517	IMP dehydrogenase activity
BC6307_RS17110	COG0123	including yeast histone deacetylase and acetoin utilization protein
BC6307_RS17120	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BC6307_RS17130	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BC6307_RS17130	COG1605	Chorismate mutase
BC6307_RS17135	COG4980	gas vesicle protein
BC6307_RS17150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BC6307_RS17160	COG1674	ftsk spoiiie
BC6307_RS17165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC6307_RS17170	COG4848	Belongs to the UPF0354 family
BC6307_RS17175	COG4412	M6 family metalloprotease domain protein
BC6307_RS17175	COG1404	Belongs to the peptidase S8 family
BC6307_RS17180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_RS17190	COG0840	transmembrane signaling receptor activity
BC6307_RS17210	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BC6307_RS17215	COG1363	Peptidase, m42
BC6307_RS17220	COG5584	Small secreted protein
BC6307_RS17225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS17230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BC6307_RS17240	COG0510	thiamine kinase activity
BC6307_RS17245	COG1523	belongs to the glycosyl hydrolase 13 family
BC6307_RS17255	COG1346	cytolysis
BC6307_RS17260	COG1380	Effector of murein hydrolase LrgA
BC6307_RS17270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC6307_RS17280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BC6307_RS17285	COG1472	Belongs to the glycosyl hydrolase 3 family
BC6307_RS17290	COG3876	Protein conserved in bacteria
BC6307_RS17300	COG3842	ATPase activity
BC6307_RS17305	COG0395	ABC-type sugar transport system, permease component
BC6307_RS17310	COG1175	transmembrane transport
BC6307_RS17320	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BC6307_RS17335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_RS17345	COG1131	(ABC) transporter
BC6307_RS17350	COG1349	DNA-binding transcription factor activity
BC6307_RS17355	COG1187	pseudouridine synthase activity
BC6307_RS17365	COG2244	polysaccharide biosynthetic process
BC6307_RS17375	COG2081	HI0933 family
BC6307_RS17390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS17395	COG0495	leucyl-tRNA aminoacylation
BC6307_RS17405	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS17410	COG2610	gluconate transmembrane transporter activity
BC6307_RS17425	COG2814	Major facilitator Superfamily
BC6307_RS17440	COG1242	4 iron, 4 sulfur cluster binding
BC6307_RS17445	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BC6307_RS17455	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BC6307_RS17465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC6307_RS17470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BC6307_RS17480	COG2267	carboxylic ester hydrolase activity
BC6307_RS17485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BC6307_RS17495	COG0438	transferase activity, transferring glycosyl groups
BC6307_RS17500	COG0217	transcriptional regulatory protein
BC6307_RS17505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BC6307_RS17515	COG1506	peptidase
BC6307_RS17520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BC6307_RS17525	COG1116	anion transmembrane transporter activity
BC6307_RS17530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC6307_RS17535	COG0494	nUDIX hydrolase
BC6307_RS17550	COG0783	Belongs to the Dps family
BC6307_RS17565	COG0701	Predicted permease
BC6307_RS17570	COG1854	S-ribosylhomocysteine lyase activity
BC6307_RS17575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BC6307_RS17580	COG0288	reversible hydration of carbon dioxide
BC6307_RS17585	COG0523	cobalamin synthesis protein
BC6307_RS17595	COG1404	Belongs to the peptidase S8 family
BC6307_RS17600	COG0523	cobalamin synthesis protein
BC6307_RS17610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC6307_RS17615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC6307_RS17615	COG1321	iron dependent repressor
BC6307_RS17620	COG1121	(ABC) transporter
BC6307_RS17625	COG0803	Belongs to the bacterial solute-binding protein 9 family
BC6307_RS17630	COG0318	PFAM AMP-dependent synthetase and ligase
BC6307_RS17635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BC6307_RS17640	COG0596	Alpha beta hydrolase
BC6307_RS17645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BC6307_RS17650	COG1169	isochorismate synthase
BC6307_RS17655	COG1575	Belongs to the MenA family. Type 1 subfamily
BC6307_RS17660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BC6307_RS17670	COG0058	SHG alpha-glucan phosphorylase activity
BC6307_RS17675	COG0297	glycogen (starch) synthase activity
BC6307_RS17680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BC6307_RS17685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BC6307_RS17840	COG1285	pathogenesis
BC6307_RS17890	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC6307_RS18025	COG5484	DNA packaging
BC6307_RS18040	COG3677	Transposase
BC6307_RS18075	COG2201	protein-glutamate methylesterase activity
BC6307_RS18095	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BC6307_RS18110	COG1484	DNA-dependent DNA replication
BC6307_RS18190	COG1396	sequence-specific DNA binding
BC6307_RS18220	COG2223	nitrite transmembrane transporter activity
BC6307_RS18230	COG0243	molybdopterin cofactor binding
BC6307_RS18235	COG0437	4 iron, 4 sulfur cluster binding
BC6307_RS18240	COG0723	plastoquinol--plastocyanin reductase activity
BC6307_RS18255	COG0489	protein tyrosine kinase activity
BC6307_RS18265	COG1366	Belongs to the anti-sigma-factor antagonist family
BC6307_RS18280	COG1280	lysine exporter protein (LysE YggA)
BC6307_RS18295	COG1113	amino acid transport
BC6307_RS18300	COG1280	lysine exporter protein (LysE YggA)
BC6307_RS18310	COG3314	Sporulation integral membrane protein YlbJ
BC6307_RS18315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BC6307_RS18320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BC6307_RS18325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BC6307_RS18340	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BC6307_RS18345	COG0673	inositol 2-dehydrogenase activity
BC6307_RS18360	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS18375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BC6307_RS18395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BC6307_RS18395	COG2111	Na H antiporter
BC6307_RS18400	COG2111	Na H antiporter
BC6307_RS18405	COG1006	Multisubunit Na H antiporter MnhC subunit
BC6307_RS18410	COG0651	ATP synthesis coupled electron transport
BC6307_RS18415	COG1863	multisubunit Na H antiporter MnhE subunit
BC6307_RS18420	COG2212	antiporter activity
BC6307_RS18425	COG1320	monovalent cation:proton antiporter activity
BC6307_RS18430	COG1979	alcohol dehydrogenase
BC6307_RS18435	COG2155	Conserved Protein
BC6307_RS18440	COG1098	S1 RNA binding domain
BC6307_RS18445	COG2267	carboxylic ester hydrolase activity
BC6307_RS18460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BC6307_RS18470	COG2032	superoxide dismutase activity
BC6307_RS18480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BC6307_RS18490	COG5018	Exonuclease
BC6307_RS18495	COG2814	Major facilitator Superfamily
BC6307_RS18505	COG2050	protein possibly involved in aromatic compounds catabolism
BC6307_RS18530	COG1595	DNA-templated transcription, initiation
BC6307_RS18540	COG4555	ABC transporter
BC6307_RS18545	COG0772	Belongs to the SEDS family
BC6307_RS18550	COG0772	Belongs to the SEDS family
BC6307_RS18560	COG1268	BioY protein
BC6307_RS18565	COG2056	Na+-H+ antiporter family
BC6307_RS18580	COG0697	spore germination
BC6307_RS18585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BC6307_RS18595	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BC6307_RS18600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC6307_RS18605	COG3584	3D domain protein
BC6307_RS18620	COG1252	NADH dehydrogenase
BC6307_RS18635	COG0316	Belongs to the HesB IscA family
BC6307_RS18640	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BC6307_RS18645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BC6307_RS18655	COG1252	NADH dehydrogenase
BC6307_RS18660	COG4837	Protein of unknown function (DUF1462)
BC6307_RS18665	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BC6307_RS18670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC6307_RS18675	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BC6307_RS18680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BC6307_RS18685	COG0647	UMP catabolic process
BC6307_RS18690	COG2445	Protein of unknown function DUF86
BC6307_RS18705	COG4470	Protein conserved in bacteria
BC6307_RS18715	COG1011	Hydrolase
BC6307_RS18720	COG0527	aspartate kinase activity
BC6307_RS18730	COG0739	heme binding
BC6307_RS18740	COG0733	neurotransmitter:sodium symporter activity
BC6307_RS18745	COG1757	Na H antiporter
BC6307_RS18760	COG3377	Domain of unknown function (DUF1805)
BC6307_RS18765	COG0737	Belongs to the 5'-nucleotidase family
BC6307_RS18770	COG0730	response to heat
BC6307_RS18775	COG1801	Protein of unknown function DUF72
BC6307_RS18790	COG0719	Fe-S assembly protein
BC6307_RS18795	COG0822	iron-sulfur transferase activity
BC6307_RS18800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BC6307_RS18805	COG0719	Fe-S assembly protein
BC6307_RS18810	COG0396	ATPase activity
BC6307_RS18815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BC6307_RS18820	COG1464	Belongs to the NlpA lipoprotein family
BC6307_RS18825	COG2011	ABC-type metal ion transport system permease component
BC6307_RS18830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC6307_RS18840	COG2814	Major facilitator Superfamily
BC6307_RS18845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_RS18850	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BC6307_RS18870	COG0509	glycine decarboxylation via glycine cleavage system
BC6307_RS18875	COG1393	Belongs to the ArsC family
BC6307_RS18880	COG1960	acyl-CoA dehydrogenase activity
BC6307_RS18885	COG0183	Belongs to the thiolase family
BC6307_RS18890	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC6307_RS18890	COG1024	Enoyl-CoA hydratase
BC6307_RS18910	COG5577	PFAM Coat F domain
BC6307_RS18925	COG1120	ATPase activity
BC6307_RS18930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC6307_RS18935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC6307_RS18940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC6307_RS18945	COG0584	glycerophosphoryl diester phosphodiesterase
BC6307_RS18950	COG0737	Belongs to the 5'-nucleotidase family
BC6307_RS18960	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS18965	COG0750	zinc metalloprotease
BC6307_RS18985	COG1595	DNA-templated transcription, initiation
BC6307_RS18990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS18990	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS18995	COG1054	Belongs to the UPF0176 family
BC6307_RS19000	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_RS19005	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS19010	COG1937	Protein conserved in bacteria
BC6307_RS19015	COG0726	polysaccharide deacetylase
BC6307_RS19020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BC6307_RS19025	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BC6307_RS19035	COG1063	alcohol dehydrogenase
BC6307_RS19050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_RS19050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_RS19080	COG3344	reverse transcriptase
BC6307_RS19160	COG1131	(ABC) transporter
BC6307_RS19215	COG0210	DNA helicase
BC6307_RS19220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BC6307_RS19230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BC6307_RS19235	COG0557	exoribonuclease II activity
BC6307_RS19240	COG1647	Serine aminopeptidase, S33
BC6307_RS19250	COG1396	sequence-specific DNA binding
BC6307_RS19260	COG0681	Belongs to the peptidase S26 family
BC6307_RS19280	COG5002	protein histidine kinase activity
BC6307_RS19285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BC6307_RS19295	COG0148	phosphopyruvate hydratase activity
BC6307_RS19305	COG0149	triose-phosphate isomerase activity
BC6307_RS19315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BC6307_RS19330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BC6307_RS19460	COG0740	serine-type endopeptidase activity
BC6307_RS19470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC6307_RS19475	COG1481	regulation of sporulation
BC6307_RS19480	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BC6307_RS19485	COG1660	Displays ATPase and GTPase activities
BC6307_RS19490	COG1051	belongs to the nudix hydrolase family
BC6307_RS19495	COG0492	ferredoxin-NADP+ reductase activity
BC6307_RS19500	COG0457	Tetratricopeptide repeat
BC6307_RS19505	COG0140	phosphoribosyl-ATP diphosphatase activity
BC6307_RS19505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BC6307_RS19510	COG0107	imidazoleglycerol-phosphate synthase activity
BC6307_RS19515	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BC6307_RS19520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BC6307_RS19525	COG0131	Imidazoleglycerol-phosphate dehydratase
BC6307_RS19530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BC6307_RS19540	COG0110	maltose O-acetyltransferase activity
BC6307_RS19545	COG0546	phosphoglycolate phosphatase activity
BC6307_RS19550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BC6307_RS19565	COG1950	PFAM Membrane protein of
BC6307_RS19570	COG1983	PspC domain protein
BC6307_RS19575	COG3595	metallopeptidase activity
BC6307_RS19590	COG0840	transmembrane signaling receptor activity
BC6307_RS19595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BC6307_RS19600	COG0556	nucleotide-excision repair
BC6307_RS19615	COG1595	DNA-templated transcription, initiation
BC6307_RS19620	COG4897	Protein conserved in bacteria
BC6307_RS19630	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BC6307_RS19645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BC6307_RS19650	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BC6307_RS19655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC6307_RS19660	COG3409	Peptidoglycan-binding domain 1 protein
BC6307_RS19660	COG0793	Belongs to the peptidase S41A family
BC6307_RS19665	COG0739	heme binding
BC6307_RS19670	COG2177	Part of the ABC transporter FtsEX involved in
BC6307_RS19675	COG2884	Cell division ATP-binding protein ftsE
BC6307_RS19685	COG1404	Belongs to the peptidase S8 family
BC6307_RS19695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC6307_RS19710	COG0653	protein targeting
BC6307_RS19720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BC6307_RS19740	COG1516	flagellar protein fliS
BC6307_RS19745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BC6307_RS19760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BC6307_RS19765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BC6307_RS19770	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BC6307_RS19780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BC6307_RS19785	COG4786	Flagellar basal body rod
BC6307_RS19785	COG1256	bacterial-type flagellum assembly
BC6307_RS19805	COG1040	competence protein
BC6307_RS19810	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BC6307_RS19815	COG1307	EDD domain protein, DegV family
BC6307_RS19835	COG2197	response regulator
BC6307_RS19840	COG4585	Histidine kinase
BC6307_RS19845	COG1739	Uncharacterized protein family UPF0029
BC6307_RS19850	COG1316	TRANSCRIPTIONal
BC6307_RS19855	COG0438	transferase activity, transferring glycosyl groups
BC6307_RS19860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BC6307_RS19865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BC6307_RS19885	COG4464	protein tyrosine phosphatase activity
BC6307_RS19890	COG3764	Sortase (surface protein transpeptidase)
BC6307_RS19905	COG4715	Zinc finger, swim domain protein
BC6307_RS19910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BC6307_RS19925	COG0629	single-stranded DNA binding
BC6307_RS19935	COG3764	Sortase (surface protein transpeptidase)
BC6307_RS19960	COG1215	transferase activity, transferring glycosyl groups
BC6307_RS19970	COG4193	domain, Protein
BC6307_RS19975	COG0463	Glycosyl transferase, family 2
BC6307_RS19990	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC6307_RS19990	COG2247	cell wall binding repeat
BC6307_RS19995	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BC6307_RS19995	COG2755	lipolytic protein G-D-S-L family
BC6307_RS20010	COG1215	transferase activity, transferring glycosyl groups
BC6307_RS20015	COG0438	transferase activity, transferring glycosyl groups
BC6307_RS20020	COG1653	transport
BC6307_RS20025	COG0395	ABC-type sugar transport system, permease component
BC6307_RS20030	COG1175	transmembrane transport
BC6307_RS20040	COG1316	TRANSCRIPTIONal
BC6307_RS20045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC6307_RS20080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC6307_RS20090	COG1464	Belongs to the NlpA lipoprotein family
BC6307_RS20095	COG0371	Dehydrogenase
BC6307_RS20100	COG2031	fatty acid transporter
BC6307_RS20105	COG2962	Rard protein
BC6307_RS20130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BC6307_RS20160	COG2972	Histidine kinase
BC6307_RS20165	COG2182	Extracellular solute-binding protein
BC6307_RS20205	COG1404	Belongs to the peptidase S8 family
BC6307_RS20210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BC6307_RS20215	COG0673	inositol 2-dehydrogenase activity
BC6307_RS20225	COG0366	Alpha amylase catalytic
BC6307_RS20230	COG1653	transport
BC6307_RS20235	COG4753	response regulator
BC6307_RS20235	COG2207	Transcriptional regulator
BC6307_RS20250	COG0395	ABC-type sugar transport system, permease component
BC6307_RS20255	COG1175	transmembrane transport
BC6307_RS20260	COG1653	transport
BC6307_RS20425	COG1505	serine-type exopeptidase activity
BC6307_RS20440	COG4213	ABC transporter substrate-binding protein
BC6307_RS20445	COG2207	Transcriptional regulator
BC6307_RS20445	COG4753	response regulator
BC6307_RS20450	COG2972	Histidine kinase
BC6307_RS20460	COG4214	carbohydrate transport
BC6307_RS20470	COG4213	ABC transporter substrate-binding protein
BC6307_RS20525	COG2706	6-phosphogluconolactonase activity
BC6307_RS20530	COG1301	dicarboxylic acid transport
BC6307_RS20580	COG0561	phosphatase activity
BC6307_RS20595	COG1063	alcohol dehydrogenase
BC6307_RS20600	COG1172	Belongs to the binding-protein-dependent transport system permease family
BC6307_RS20605	COG1129	ABC transporter
BC6307_RS20610	COG1879	ABC-type sugar transport system periplasmic component
BC6307_RS20630	COG1473	amidohydrolase
BC6307_RS20650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BC6307_RS20660	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_RS20665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BC6307_RS20725	COG1131	(ABC) transporter
BC6307_RS20740	COG1757	Na H antiporter
BC6307_RS20790	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BC6307_RS20795	COG1072	(Pantothenic acid kinase))
BC6307_RS20805	COG2801	Transposase and inactivated derivatives
BC6307_RS20815	COG5583	Uncharacterized small protein (DUF2292)
BC6307_RS20820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BC6307_RS20830	COG3973	AAA domain
BC6307_RS20840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BC6307_RS20865	COG0561	phosphatase activity
BC6307_RS20915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC6307_RS20950	COG0457	Tetratricopeptide repeat
BC6307_RS20950	COG0463	Glycosyl transferase, family 2
BC6307_RS20980	COG2814	Major facilitator Superfamily
BC6307_RS21010	COG5002	protein histidine kinase activity
BC6307_RS21015	COG0745	RESPONSE REGULATOR receiver
BC6307_RS21020	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BC6307_RS21025	COG1131	(ABC) transporter
BC6307_RS21035	COG1505	serine-type exopeptidase activity
BC6307_RS21105	COG1078	dGTPase activity
BC6307_RS21110	COG2252	PERMEase
BC6307_RS21120	COG0606	chelatase, subunit chli
BC6307_RS21140	COG3273	potassium ion transport
BC6307_RS21140	COG0471	metal ion transport
BC6307_RS21145	COG5001	Diguanylate cyclase
BC6307_RS21145	COG3300	MHYT domain
BC6307_RS21165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_RS21170	COG0785	Cytochrome C biogenesis protein
BC6307_RS21180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS21200	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS21205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS21205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS21220	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS21220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS21235	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_RS21240	COG1937	Protein conserved in bacteria
BC6307_RS21250	COG0730	response to heat
BC6307_RS21255	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS21260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS21260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_RS21270	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_RS21275	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_RS21275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS21280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_RS21305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BC6307_RS21315	COG5444	nuclease activity
BC6307_RS21345	COG2801	Transposase and inactivated derivatives
BC6307_RS21355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BC6307_RS21360	COG0728	peptidoglycan biosynthetic process
BC6307_RS21370	COG0438	transferase activity, transferring glycosyl groups
BC6307_RS21400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BC6307_RS21400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC6307_RS21420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BC6307_RS21430	COG1086	Polysaccharide biosynthesis protein
BC6307_RS21435	COG0489	protein tyrosine kinase activity
BC6307_RS21440	COG3944	biosynthesis protein
BC6307_RS21485	COG4786	Flagellar basal body rod
BC6307_RS21500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC6307_RS21505	COG0765	amino acid transport
BC6307_RS21510	COG1126	abc transporter atp-binding protein
BC6307_RS21530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_RS21535	COG2323	membrane
BC6307_RS21545	COG2197	response regulator
BC6307_RS21550	COG4585	Histidine kinase
BC6307_RS21555	COG3239	Fatty acid desaturase
BC6307_RS21565	COG1511	domain protein
BC6307_RS21570	COG1309	transcriptional regulator
BC6307_RS21575	COG0702	epimerase
BC6307_RS21580	COG1393	Belongs to the ArsC family
BC6307_RS21600	COG2226	methyltransferase
BC6307_RS21605	COG1476	TRANSCRIPTIONal
BC6307_RS21615	COG2723	6-phospho-beta-galactosidase activity
BC6307_RS21625	COG1077	Cell shape determining protein MreB Mrl
BC6307_RS21630	COG1609	Transcriptional regulator
BC6307_RS21645	COG0604	alcohol dehydrogenase
BC6307_RS21725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_RS21735	COG0456	acetyltransferase
BC6307_RS21755	COG2153	protein acetylation
BC6307_RS21765	COG5002	protein histidine kinase activity
BC6307_RS21765	COG2176	DNA-directed DNA polymerase activity
BC6307_RS21780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC6307_RS21800	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BC6307_RS21805	COG2059	Chromate
BC6307_RS21810	COG2059	Chromate
BC6307_RS21820	COG0405	Gamma-glutamyltransferase
BC6307_RS21825	COG3852	Histidine kinase
BC6307_RS21830	COG3852	Histidine kinase
BC6307_RS21835	COG0739	heme binding
BC6307_RS21855	COG2385	sporulation resulting in formation of a cellular spore
BC6307_RS21860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BC6307_RS21870	COG4836	Membrane
BC6307_RS21875	COG1007	ATP synthesis coupled electron transport
BC6307_RS21885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BC6307_RS21890	COG0713	ATP synthesis coupled electron transport
BC6307_RS21895	COG0839	Belongs to the complex I subunit 6 family
BC6307_RS21900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC6307_RS21905	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BC6307_RS21915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC6307_RS21920	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC6307_RS21930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BC6307_RS21935	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BC6307_RS21940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BC6307_RS21945	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BC6307_RS21950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC6307_RS21955	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BC6307_RS21960	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC6307_RS21965	COG0356	it plays a direct role in the translocation of protons across the membrane
BC6307_RS21980	COG1404	Belongs to the peptidase S8 family
BC6307_RS21990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BC6307_RS22005	COG1595	DNA-templated transcription, initiation
BC6307_RS22015	COG0698	ribose 5-phosphate isomerase
BC6307_RS22020	COG0840	transmembrane signaling receptor activity
BC6307_RS22020	COG5278	phosphoserine phosphatase activity
BC6307_RS22025	COG0840	transmembrane signaling receptor activity
BC6307_RS22035	COG1971	Probably functions as a manganese efflux pump
BC6307_RS22040	COG0009	L-threonylcarbamoyladenylate synthase
BC6307_RS22055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BC6307_RS22090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BC6307_RS22100	COG0697	spore germination
BC6307_RS22105	COG1435	thymidine kinase activity
BC6307_RS22120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BC6307_RS22125	COG1494	fructose-1,6-bisphosphatase
BC6307_RS22135	COG0191	fructose-bisphosphate aldolase activity
BC6307_RS22140	COG2204	response regulator
BC6307_RS22145	COG4821	SIS domain
BC6307_RS22150	COG0504	CTP synthase activity
BC6307_RS22155	COG3343	RNA polymerase activity
BC6307_RS22160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC6307_RS22160	COG1703	isobutyryl-CoA mutase activity
BC6307_RS22160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC6307_RS22165	COG3226	Transcriptional regulator
BC6307_RS22170	COG1960	acyl-CoA dehydrogenase activity
BC6307_RS22175	COG1960	acyl-CoA dehydrogenase activity
BC6307_RS22180	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC6307_RS22190	COG0183	Belongs to the thiolase family
BC6307_RS22195	COG0247	lactate metabolic process
BC6307_RS22195	COG2181	nitrate reductase activity
BC6307_RS22200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC6307_RS22215	COG1595	DNA-templated transcription, initiation
BC6307_RS22235	COG0675	Transposase, IS605 OrfB family
BC6307_RS22240	COG0010	Belongs to the arginase family
BC6307_RS22245	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BC6307_RS22250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC6307_RS22260	COG1994	Peptidase M50
BC6307_RS22270	COG0456	acetyltransferase
BC6307_RS22280	COG3465	dGTPase activity
BC6307_RS22285	COG1078	dGTPase activity
BC6307_RS22305	COG0095	Lipoate-protein ligase
BC6307_RS22310	COG0280	phosphate acetyltransferase
BC6307_RS22315	COG3253	May function as heme-dependent peroxidase
BC6307_RS22325	COG2363	Small membrane protein
BC6307_RS22330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BC6307_RS22340	COG1984	allophanate hydrolase subunit 2
BC6307_RS22355	COG2322	membrane
BC6307_RS22380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BC6307_RS22385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BC6307_RS22405	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BC6307_RS22415	COG0501	Belongs to the peptidase M48B family
BC6307_RS22430	COG0778	Nitroreductase
BC6307_RS22440	COG2031	fatty acid transporter
BC6307_RS22445	COG0561	phosphatase activity
BC6307_RS22455	COG3314	Sporulation integral membrane protein YlbJ
BC6307_RS22490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC6307_RS22490	COG0551	DNA topoisomerase type I activity
BC6307_RS22495	COG0488	(ABC) transporter
BC6307_RS22520	COG1595	DNA-templated transcription, initiation
BC6307_RS22540	COG3842	ATPase activity
BC6307_RS22550	COG1840	ABC-type Fe3 transport system, periplasmic component
BC6307_RS22555	COG1794	racemase activity, acting on amino acids and derivatives
BC6307_RS22565	COG0367	asparagine synthase
BC6307_RS22570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BC6307_RS22575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BC6307_RS22580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BC6307_RS22595	COG4187	Peptidase family M20/M25/M40
BC6307_RS22600	COG1079	Belongs to the binding-protein-dependent transport system permease family
BC6307_RS22605	COG4603	Belongs to the binding-protein-dependent transport system permease family
BC6307_RS22610	COG3845	ABC transporter
BC6307_RS22615	COG1744	ABC transporter substrate-binding protein PnrA-like
BC6307_RS22620	COG1959	2 iron, 2 sulfur cluster binding
BC6307_RS22630	COG2814	Major facilitator Superfamily
BC6307_RS22645	COG1187	pseudouridine synthase activity
BC6307_RS22650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC6307_RS22665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_RS22675	COG4608	Belongs to the ABC transporter superfamily
BC6307_RS22680	COG0444	Belongs to the ABC transporter superfamily
BC6307_RS22685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC6307_RS22690	COG0601	transmembrane transport
BC6307_RS22695	COG0747	negative chemotaxis
BC6307_RS22710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC6307_RS22715	COG0561	phosphatase activity
BC6307_RS22720	COG0798	PFAM Bile acid sodium symporter
BC6307_RS22735	COG1279	arginine transmembrane transporter activity
BC6307_RS22750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BC6307_RS22755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BC6307_RS22770	COG4191	Histidine kinase
BC6307_RS22775	COG1966	Carbon starvation protein
BC6307_RS22805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC6307_RS22810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BC6307_RS22820	COG4863	YycH protein
BC6307_RS22825	COG5002	protein histidine kinase activity
BC6307_RS22830	COG0745	RESPONSE REGULATOR receiver
BC6307_RS22835	COG0741	lytic transglycosylase activity
BC6307_RS22835	COG1196	nuclear chromosome segregation
BC6307_RS22835	COG0739	heme binding
BC6307_RS22865	COG0305	Participates in initiation and elongation during chromosome replication
BC6307_RS22870	COG0359	binds to the 23S rRNA
BC6307_RS22875	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BC6307_RS22885	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BC6307_RS22895	COG0360	Binds together with S18 to 16S ribosomal RNA
BC6307_RS22900	COG0012	GTP binding
BC6307_RS22905	COG4481	Protein conserved in bacteria
BC6307_RS22910	COG3949	Membrane
BC6307_RS22925	COG1475	DNA binding
BC6307_RS22930	COG1192	Involved in chromosome partitioning
BC6307_RS22935	COG1475	DNA binding
BC6307_RS22940	COG0357	Ribosomal RNA small subunit methyltransferase G
BC6307_RS22945	COG0445	tRNA wobble uridine modification
BC6307_RS22950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BC6307_RS22955	COG1847	R3H domain protein
BC6307_RS22970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BC6307_RS22975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BC6307_RS22980	COG0592	DNA-directed DNA polymerase activity
BC6307_RS22985	COG2501	S4 domain
BC6307_RS22990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BC6307_RS23000	COG0187	DNA topoisomerase II activity
BC6307_RS23005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BC6307_RS23010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BC6307_RS23010	COG2199	diguanylate cyclase activity
BC6307_RS23050	COG0517	IMP dehydrogenase activity
BC6307_RS23050	COG0516	GMP reductase activity
BC6307_RS23060	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BC6307_RS23065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BC6307_RS23070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BC6307_RS23080	COG1428	Deoxynucleoside kinase
BC6307_RS23085	COG1428	Deoxynucleoside kinase
BC6307_RS23090	COG1335	isochorismatase
BC6307_RS23095	COG0590	tRNA wobble adenosine to inosine editing
BC6307_RS23105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BC6307_RS23110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BC6307_RS23160	COG1982	Orn Lys Arg decarboxylase major
BC6307_RS23165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BC6307_RS23170	COG3870	Protein conserved in bacteria
BC6307_RS23175	COG1728	Protein conserved in bacteria
BC6307_RS23180	COG0470	DNA polymerase III
BC6307_RS23185	COG1774	PSP1 C-terminal conserved region
BC6307_RS23190	COG4467	Involved in initiation control of chromosome replication
BC6307_RS23195	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BC6307_RS23200	COG2827	Endonuclease containing a URI domain
BC6307_RS23205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BC6307_RS23210	COG2002	toxin-antitoxin pair type II binding
BC6307_RS23220	COG0084	hydrolase, TatD family'
BC6307_RS23225	COG3583	domain protein
BC6307_RS23225	COG3584	3D domain protein
BC6307_RS23230	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BC6307_RS23235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BC6307_RS23245	COG4466	Protein conserved in bacteria
BC6307_RS23255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BC6307_RS23260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC6307_RS23265	COG0251	oxidation-reduction process
BC6307_RS23275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BC6307_RS23285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BC6307_RS23300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BC6307_RS23305	COG2002	toxin-antitoxin pair type II binding
BC6307_RS23310	COG2244	polysaccharide biosynthetic process
BC6307_RS23315	COG3956	TIGRFAM MazG family protein
BC6307_RS23320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BC6307_RS23340	COG1098	S1 RNA binding domain
BC6307_RS23355	COG2208	phosphoserine phosphatase activity
BC6307_RS23360	COG2304	oxidoreductase activity
BC6307_RS23365	COG0515	serine threonine protein kinase
BC6307_RS23375	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BC6307_RS23380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BC6307_RS23385	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BC6307_RS23390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BC6307_RS23395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC6307_RS23400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC6307_RS23405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BC6307_RS23410	COG0512	Glutamine amidotransferase of anthranilate synthase
BC6307_RS23415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BC6307_RS23420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BC6307_RS23425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BC6307_RS23430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BC6307_RS23435	COG1396	sequence-specific DNA binding
BC6307_RS23440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BC6307_RS23530	COG3880	PFAM UvrB UvrC protein
BC6307_RS23535	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BC6307_RS23540	COG0542	response to heat
BC6307_RS23545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BC6307_RS23550	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BC6307_RS23555	COG4956	integral membrane protein (PIN domain superfamily)
BC6307_RS23560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BC6307_RS23565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BC6307_RS23570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BC6307_RS23575	COG1045	serine acetyltransferase
BC6307_RS23580	COG0215	cysteine-tRNA ligase activity
BC6307_RS23590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC6307_RS23595	COG3688	RNA-binding protein containing a PIN domain
BC6307_RS23605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BC6307_RS23610	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BC6307_RS23615	COG0250	Participates in transcription elongation, termination and antitermination
BC6307_RS23620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BC6307_RS23625	COG0081	regulation of translation
BC6307_RS23630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BC6307_RS23635	COG0222	ribosome binding
BC6307_RS23640	COG2813	Specifically methylates the guanine in position
BC6307_RS23645	COG0085	RNA polymerase activity
BC6307_RS23655	COG1358	cellular component organization or biogenesis
BC6307_RS23660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BC6307_RS23670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BC6307_RS23675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BC6307_RS23680	COG0051	transcription antitermination factor activity, RNA binding
BC6307_RS23685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BC6307_RS23690	COG0088	Forms part of the polypeptide exit tunnel
BC6307_RS23695	COG0089	rRNA binding
BC6307_RS23700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BC6307_RS23705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BC6307_RS23720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BC6307_RS23725	COG0255	Belongs to the universal ribosomal protein uL29 family
BC6307_RS23730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BC6307_RS23735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BC6307_RS23740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BC6307_RS23745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BC6307_RS23750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BC6307_RS23755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BC6307_RS23760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BC6307_RS23765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BC6307_RS23770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BC6307_RS23775	COG1841	ribosomal large subunit assembly
BC6307_RS23780	COG0200	Binds to the 23S rRNA
BC6307_RS23785	COG0201	protein transport
BC6307_RS23790	COG0563	adenylate kinase activity
BC6307_RS23795	COG0024	Methionine aminopeptidase
BC6307_RS23800	COG2163	COG2163 Ribosomal protein L14E L6E L27E
BC6307_RS23805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BC6307_RS23810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BC6307_RS23815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BC6307_RS23820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BC6307_RS23830	COG0203	ribosomal protein L17
BC6307_RS23835	COG1122	ATPase activity
BC6307_RS23845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BC6307_RS23850	COG0101	tRNA pseudouridine synthase activity
BC6307_RS23855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BC6307_RS23860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BC6307_RS23865	COG1216	Glycosyl transferase, family 2
BC6307_RS23870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BC6307_RS23875	COG0655	NAD(P)H dehydrogenase (quinone) activity
BC6307_RS23890	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC6307_RS23895	COG0489	protein tyrosine kinase activity
BC6307_RS23905	COG2194	sulfuric ester hydrolase activity
BC6307_RS23910	COG0726	polysaccharide deacetylase
BC6307_RS23980	COG1595	DNA-templated transcription, initiation
BC6307_RS23985	COG5662	AntiSigma factor
BC6307_RS23990	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BC6307_RS23995	COG4856	YbbR-like protein
BC6307_RS24000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC6307_RS24005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BC6307_RS24010	COG0402	S-adenosylhomocysteine deaminase activity
BC6307_RS24025	COG0318	PFAM AMP-dependent synthetase and ligase
BC6307_RS24035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BC6307_RS24040	COG0432	Pfam Uncharacterised protein family UPF0047
BC6307_RS24045	COG2002	toxin-antitoxin pair type II binding
BC6307_RS24055	COG1733	regulation of RNA biosynthetic process
BC6307_RS24060	COG2514	catechol 2,3-dioxygenase activity
BC6307_RS24070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BC6307_RS24075	COG3973	AAA domain
BC6307_RS24090	COG1937	Protein conserved in bacteria
BC6307_RS24095	COG2608	mercury ion transmembrane transporter activity
BC6307_RS24100	COG2217	Heavy metal translocating P-type atpase
BC6307_RS24110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BC6307_RS24125	COG1181	Belongs to the D-alanine--D-alanine ligase family
BC6307_RS24130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BC6307_RS24135	COG0513	Belongs to the DEAD box helicase family
BC6307_RS24140	COG4294	response to UV
BC6307_RS24145	COG3402	PFAM membrane-flanked domain
BC6307_RS24150	COG3428	Bacterial PH domain
BC6307_RS24155	COG0705	Rhomboid family
BC6307_RS24160	COG0736	holo-[acyl-carrier-protein] synthase activity
BC6307_RS24165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BC6307_RS24170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BC6307_RS24175	COG0864	Transcriptional regulator
BC6307_RS24180	COG2337	Toxic component of a toxin-antitoxin (TA) module
BC6307_RS24185	COG1366	Belongs to the anti-sigma-factor antagonist family
BC6307_RS24190	COG1366	Belongs to the anti-sigma-factor antagonist family
BC6307_RS24195	COG2172	sigma factor antagonist activity
BC6307_RS24200	COG2208	phosphoserine phosphatase activity
BC6307_RS24205	COG1366	Belongs to the anti-sigma-factor antagonist family
BC6307_RS24210	COG2172	sigma factor antagonist activity
BC6307_RS24215	COG1191	sigma factor activity
BC6307_RS24220	COG2208	phosphoserine phosphatase activity
BC6307_RS24225	COG2183	response to ionizing radiation
BC6307_RS24235	COG3091	SprT-like family
BC6307_RS24325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BC6307_RS24335	COG1214	PFAM Peptidase M22, glycoprotease
BC6307_RS24340	COG0456	acetyltransferase
BC6307_RS24345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BC6307_RS24350	COG0488	(ABC) transporter
BC6307_RS24355	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BC6307_RS24360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BC6307_RS24365	COG0805	protein transport
BC6307_RS24375	COG1266	CAAX protease self-immunity
BC6307_RS24380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BC6307_RS24385	COG0459	protein refolding
BC6307_RS24400	COG0789	Transcriptional regulator
BC6307_RS24415	COG1842	Phage shock protein A
BC6307_RS24420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BC6307_RS24425	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BC6307_RS24430	COG4260	virion core protein, lumpy skin disease virus
BC6307_RS24435	COG1136	(ABC) transporter
BC6307_RS24440	COG0577	efflux transmembrane transporter activity
BC6307_RS24480	COG2304	oxidoreductase activity
BC6307_RS24530	COG0714	Associated with various cellular activities
BC6307_RS24535	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BC6307_RS24540	COG1305	Transglutaminase-like
BC6307_RS24550	COG2252	PERMEase