locus-tag	class	description
CG476_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CG476_RS00010	COG0592	DNA-directed DNA polymerase activity
CG476_RS00015	COG2501	S4 domain
CG476_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CG476_RS00025	COG0187	DNA topoisomerase II activity
CG476_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG476_RS00065	COG0516	GMP reductase activity
CG476_RS00065	COG0517	IMP dehydrogenase activity
CG476_RS00070	COG1686	Belongs to the peptidase S11 family
CG476_RS00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CG476_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CG476_RS00085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CG476_RS00100	COG1428	Deoxynucleoside kinase
CG476_RS00105	COG1428	Deoxynucleoside kinase
CG476_RS00110	COG1335	isochorismatase
CG476_RS00115	COG0590	tRNA wobble adenosine to inosine editing
CG476_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CG476_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CG476_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CG476_RS00180	COG1982	Orn Lys Arg decarboxylase major
CG476_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CG476_RS00190	COG0470	DNA polymerase III
CG476_RS00195	COG1774	PSP1 C-terminal conserved region
CG476_RS00200	COG4467	Involved in initiation control of chromosome replication
CG476_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CG476_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CG476_RS00220	COG2002	toxin-antitoxin pair type II binding
CG476_RS00230	COG0084	hydrolase, TatD family'
CG476_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CG476_RS00250	COG4466	Protein conserved in bacteria
CG476_RS00260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CG476_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG476_RS00270	COG0251	oxidation-reduction process
CG476_RS00275	COG2088	sporulation resulting in formation of a cellular spore
CG476_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CG476_RS00290	COG0193	aminoacyl-tRNA hydrolase activity
CG476_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CG476_RS00305	COG2002	toxin-antitoxin pair type II binding
CG476_RS00310	COG2244	polysaccharide biosynthetic process
CG476_RS00315	COG3956	TIGRFAM MazG family protein
CG476_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CG476_RS00340	COG1098	S1 RNA binding domain
CG476_RS00355	COG2208	phosphoserine phosphatase activity
CG476_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CG476_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CG476_RS00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CG476_RS00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CG476_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG476_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
CG476_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG476_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CG476_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CG476_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CG476_RS00420	COG1396	sequence-specific DNA binding
CG476_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG476_RS00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CG476_RS00465	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG476_RS00515	COG3880	PFAM UvrB UvrC protein
CG476_RS00520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CG476_RS00525	COG0542	response to heat
CG476_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CG476_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
CG476_RS00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CG476_RS00550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CG476_RS00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CG476_RS00560	COG1045	serine acetyltransferase
CG476_RS00565	COG0215	cysteine-tRNA ligase activity
CG476_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG476_RS00580	COG3688	RNA-binding protein containing a PIN domain
CG476_RS00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG476_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
CG476_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CG476_RS00610	COG0081	regulation of translation
CG476_RS00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CG476_RS00620	COG0222	ribosome binding
CG476_RS00625	COG2813	Specifically methylates the guanine in position
CG476_RS00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CG476_RS00640	COG1358	cellular component organization or biogenesis
CG476_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CG476_RS00650	COG0049	tRNA binding
CG476_RS00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CG476_RS00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CG476_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CG476_RS00675	COG0088	Forms part of the polypeptide exit tunnel
CG476_RS00680	COG0089	rRNA binding
CG476_RS00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CG476_RS00690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CG476_RS00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CG476_RS00700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CG476_RS00705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CG476_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
CG476_RS00715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CG476_RS00720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CG476_RS00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CG476_RS00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CG476_RS00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CG476_RS00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CG476_RS00755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CG476_RS00760	COG1841	ribosomal large subunit assembly
CG476_RS00765	COG0200	Binds to the 23S rRNA
CG476_RS00770	COG0201	protein transport
CG476_RS00775	COG0563	adenylate kinase activity
CG476_RS00780	COG0024	Methionine aminopeptidase
CG476_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CG476_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CG476_RS00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CG476_RS00805	COG0202	RNA polymerase activity
CG476_RS00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG476_RS00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CG476_RS00845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CG476_RS00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG476_RS00860	COG0489	protein tyrosine kinase activity
CG476_RS00870	COG2194	sulfuric ester hydrolase activity
CG476_RS00875	COG0726	polysaccharide deacetylase
CG476_RS00905	COG4974	Belongs to the 'phage' integrase family
CG476_RS01060	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CG476_RS01070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG476_RS01105	COG1396	sequence-specific DNA binding
CG476_RS01110	COG0602	queuosine metabolic process
CG476_RS01220	COG3681	Belongs to the UPF0597 family
CG476_RS01225	COG3681	Belongs to the UPF0597 family
CG476_RS01250	COG2814	Major facilitator Superfamily
CG476_RS01260	COG0601	transmembrane transport
CG476_RS01265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG476_RS01270	COG0444	Belongs to the ABC transporter superfamily
CG476_RS01275	COG4608	Belongs to the ABC transporter superfamily
CG476_RS01280	COG4166	transmembrane transport
CG476_RS01290	COG2207	Transcriptional regulator
CG476_RS01300	COG1309	transcriptional regulator
CG476_RS01310	COG0656	L-ascorbic acid biosynthetic process
CG476_RS01315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG476_RS01325	COG4149	molybdate abc transporter
CG476_RS01330	COG0725	ABC transporter, periplasmic molybdate-binding protein
CG476_RS01335	COG1910	domain protein
CG476_RS01340	COG0204	Acyl-transferase
CG476_RS01345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_RS01350	COG1648	precorrin-2 dehydrogenase activity
CG476_RS01350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG476_RS01360	COG1587	Uroporphyrinogen-III synthase
CG476_RS01360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG476_RS01365	COG2146	nitrite reductase [NAD(P)H] activity
CG476_RS01370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG476_RS01400	COG4585	Histidine kinase
CG476_RS01405	COG2197	response regulator
CG476_RS01410	COG1131	(ABC) transporter
CG476_RS01415	COG0842	Transport permease protein
CG476_RS01415	COG1511	domain protein
CG476_RS01420	COG0842	Transport permease protein
CG476_RS01430	COG0747	negative chemotaxis
CG476_RS01435	COG0601	transmembrane transport
CG476_RS01440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG476_RS01445	COG0444	Belongs to the ABC transporter superfamily
CG476_RS01450	COG4608	Belongs to the ABC transporter superfamily
CG476_RS01455	COG0561	phosphatase activity
CG476_RS01475	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CG476_RS01480	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG476_RS01490	COG2814	Major facilitator Superfamily
CG476_RS01495	COG1181	Belongs to the D-alanine--D-alanine ligase family
CG476_RS01500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CG476_RS01510	COG0705	Rhomboid family
CG476_RS01510	COG0457	Tetratricopeptide repeat
CG476_RS01515	COG0736	holo-[acyl-carrier-protein] synthase activity
CG476_RS01520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CG476_RS01530	COG0864	Transcriptional regulator
CG476_RS01535	COG2337	Toxic component of a toxin-antitoxin (TA) module
CG476_RS01540	COG2183	response to ionizing radiation
CG476_RS01550	COG3091	SprT-like family
CG476_RS01590	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG476_RS01640	COG0802	atpase or kinase
CG476_RS01645	COG1214	PFAM Peptidase M22, glycoprotease
CG476_RS01650	COG0456	acetyltransferase
CG476_RS01660	COG0488	(ABC) transporter
CG476_RS01665	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CG476_RS01675	COG1266	CAAX protease self-immunity
CG476_RS01680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CG476_RS01685	COG0459	protein refolding
CG476_RS01690	COG0519	Catalyzes the synthesis of GMP from XMP
CG476_RS01690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CG476_RS01695	COG2252	PERMEase
CG476_RS01705	COG5002	protein histidine kinase activity
CG476_RS01775	COG2205	protein histidine kinase activity
CG476_RS01780	COG0745	RESPONSE REGULATOR receiver
CG476_RS01800	COG0697	spore germination
CG476_RS01825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CG476_RS01830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CG476_RS01835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CG476_RS01840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CG476_RS01845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG476_RS01850	COG0047	phosphoribosylformylglycinamidine synthase activity
CG476_RS01855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG476_RS01860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CG476_RS01865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CG476_RS01870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CG476_RS01875	COG0138	bifunctional purine biosynthesis protein purh
CG476_RS01880	COG0151	Belongs to the GarS family
CG476_RS01890	COG0583	DNA-binding transcription factor activity
CG476_RS01910	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CG476_RS01915	COG0210	DNA helicase
CG476_RS01920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CG476_RS01925	COG4851	CamS sex pheromone cAM373 precursor
CG476_RS01935	COG1012	belongs to the aldehyde dehydrogenase family
CG476_RS01940	COG1335	isochorismatase
CG476_RS01950	COG2011	ABC-type metal ion transport system permease component
CG476_RS01955	COG1464	Belongs to the NlpA lipoprotein family
CG476_RS01970	COG4682	membrane
CG476_RS01975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG476_RS01980	COG0154	amidase activity
CG476_RS01985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG476_RS01990	COG1597	lipid kinase activity
CG476_RS01995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CG476_RS02000	COG0546	phosphoglycolate phosphatase activity
CG476_RS02005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CG476_RS02015	COG0531	amino acid
CG476_RS02020	COG1012	belongs to the aldehyde dehydrogenase family
CG476_RS02025	COG2076	Multidrug Resistance protein
CG476_RS02030	COG2309	aminopeptidase activity
CG476_RS02045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG476_RS02050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG476_RS02055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG476_RS02070	COG0450	alkyl hydroperoxide reductase
CG476_RS02095	COG0714	Associated with various cellular activities
CG476_RS02130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_RS02135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_RS02140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG476_RS02145	COG0492	ferredoxin-NADP+ reductase activity
CG476_RS02155	COG0166	Belongs to the GPI family
CG476_RS02160	COG5002	protein histidine kinase activity
CG476_RS02185	COG3541	Predicted nucleotidyltransferase
CG476_RS02190	COG2814	Major facilitator Superfamily
CG476_RS02195	COG0723	plastoquinol--plastocyanin reductase activity
CG476_RS02195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG476_RS02205	COG0765	amino acid transport
CG476_RS02210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG476_RS02220	COG0840	transmembrane signaling receptor activity
CG476_RS02235	COG2235	arginine
CG476_RS02250	COG0549	Belongs to the carbamate kinase family
CG476_RS02255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG476_RS02265	COG0366	Alpha amylase catalytic
CG476_RS02270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG476_RS02270	COG2190	(PTS) system
CG476_RS02270	COG1263	PTS System
CG476_RS02290	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_RS02295	COG4605	iron ion homeostasis
CG476_RS02300	COG4604	ABC transporter, ATP-binding protein
CG476_RS02305	COG4607	ABC-type enterochelin transport system periplasmic component
CG476_RS02310	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CG476_RS02315	COG0352	thiamine-phosphate diphosphorylase activity
CG476_RS02320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CG476_RS02340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG476_RS02350	COG1116	anion transmembrane transporter activity
CG476_RS02430	COG2963	transposase activity
CG476_RS02435	COG2801	Transposase and inactivated derivatives
CG476_RS02445	COG2270	Major facilitator Superfamily
CG476_RS02470	COG2310	stress, protein
CG476_RS02475	COG2310	stress, protein
CG476_RS02480	COG2310	stress, protein
CG476_RS02485	COG0861	Integral membrane protein TerC family
CG476_RS02495	COG3853	Toxic anion resistance protein (TelA)
CG476_RS02505	COG4840	Belongs to the UPF0435 family
CG476_RS02510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG476_RS02520	COG1295	ribonuclease BN
CG476_RS02525	COG2217	Heavy metal translocating P-type atpase
CG476_RS02530	COG0697	spore germination
CG476_RS02540	COG0681	Belongs to the peptidase S26 family
CG476_RS02550	COG0586	Pfam SNARE associated Golgi protein
CG476_RS02565	COG0387	Pfam Sodium calcium exchanger
CG476_RS02575	COG0535	radical SAM domain protein
CG476_RS02595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CG476_RS02620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG476_RS02645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG476_RS02675	COG2066	Belongs to the glutaminase family
CG476_RS02680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG476_RS02680	COG1263	PTS System
CG476_RS02685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG476_RS02695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG476_RS02695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG476_RS02705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CG476_RS02710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG476_RS02725	COG0402	S-adenosylhomocysteine deaminase activity
CG476_RS02730	COG2137	regulation of response to DNA damage stimulus
CG476_RS02755	COG1988	membrane-bound metal-dependent
CG476_RS02760	COG1194	a g-specific adenine glycosylase
CG476_RS02785	COG3557	Belongs to the UPF0374 family
CG476_RS02790	COG1132	(ABC) transporter
CG476_RS02795	COG4129	membrane
CG476_RS02800	COG0067	glutamate synthase
CG476_RS02800	COG0069	glutamate synthase activity
CG476_RS02800	COG0070	glutamate synthase
CG476_RS02805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG476_RS02810	COG4555	ABC transporter
CG476_RS02830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CG476_RS02835	COG0735	belongs to the Fur family
CG476_RS02935	COG3157	Type VI secretion system effector, Hcp
CG476_RS02955	COG0457	Tetratricopeptide repeat
CG476_RS02960	COG0217	transcriptional regulatory protein
CG476_RS02965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CG476_RS02970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CG476_RS02990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CG476_RS03000	COG2766	serine protein kinase
CG476_RS03010	COG2718	Belongs to the UPF0229 family
CG476_RS03025	COG1280	lysine exporter protein (LysE YggA)
CG476_RS03065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG476_RS03075	COG1585	Membrane protein implicated in regulation of membrane protease activity
CG476_RS03080	COG2268	Band 7 protein
CG476_RS03105	COG4990	cell redox homeostasis
CG476_RS03115	COG3290	protein histidine kinase activity
CG476_RS03120	COG4565	transcriptional regulatory protein
CG476_RS03125	COG3493	citrate carrier protein
CG476_RS03130	COG0281	malic enzyme
CG476_RS03145	COG5002	protein histidine kinase activity
CG476_RS03150	COG0745	RESPONSE REGULATOR receiver
CG476_RS03160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CG476_RS03165	COG3383	formate dehydrogenase (NAD+) activity
CG476_RS03170	COG2427	Protein of unknown function (DUF1641)
CG476_RS03180	COG0840	transmembrane signaling receptor activity
CG476_RS03190	COG0531	amino acid
CG476_RS03205	COG0640	Transcriptional regulator
CG476_RS03210	COG2217	Heavy metal translocating P-type atpase
CG476_RS03215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CG476_RS03225	COG3227	Zinc metalloprotease (Elastase)
CG476_RS03240	COG2217	Heavy metal translocating P-type atpase
CG476_RS03260	COG2720	vancomycin resistance protein
CG476_RS03265	COG1316	TRANSCRIPTIONal
CG476_RS03275	COG1253	flavin adenine dinucleotide binding
CG476_RS03280	COG1027	Aspartate ammonia-lyase
CG476_RS03285	COG1620	l-lactate permease
CG476_RS03305	COG3104	oligopeptide transport
CG476_RS03310	COG0156	8-amino-7-oxononanoate synthase activity
CG476_RS03315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG476_RS03330	COG4548	von Willebrand factor, type A
CG476_RS03335	COG0714	Associated with various cellular activities
CG476_RS03340	COG0531	amino acid
CG476_RS03345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG476_RS03350	COG1115	amino acid carrier protein
CG476_RS03360	COG1126	abc transporter atp-binding protein
CG476_RS03365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG476_RS03370	COG0765	amino acid transport
CG476_RS03375	COG0765	amino acid transport
CG476_RS03380	COG0833	amino acid
CG476_RS03390	COG5002	protein histidine kinase activity
CG476_RS03395	COG0745	RESPONSE REGULATOR receiver
CG476_RS03405	COG0659	secondary active sulfate transmembrane transporter activity
CG476_RS03410	COG0589	response to stress
CG476_RS03420	COG0747	negative chemotaxis
CG476_RS03430	COG0601	transmembrane transport
CG476_RS03435	COG4608	Belongs to the ABC transporter superfamily
CG476_RS03445	COG2271	Major facilitator Superfamily
CG476_RS03450	COG1846	Transcriptional regulator
CG476_RS03455	COG0477	Major facilitator Superfamily
CG476_RS03460	COG1609	Transcriptional regulator
CG476_RS03465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG476_RS03470	COG1869	D-ribose catabolic process
CG476_RS03480	COG1172	Belongs to the binding-protein-dependent transport system permease family
CG476_RS03485	COG1879	ABC-type sugar transport system periplasmic component
CG476_RS03490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CG476_RS03530	COG3568	Endonuclease Exonuclease Phosphatase
CG476_RS03555	COG0840	transmembrane signaling receptor activity
CG476_RS03560	COG1388	LysM domain
CG476_RS03560	COG3584	3D domain protein
CG476_RS03565	COG1476	TRANSCRIPTIONal
CG476_RS03600	COG1114	Component of the transport system for branched-chain amino acids
CG476_RS03610	COG1113	amino acid transport
CG476_RS03615	COG2153	protein acetylation
CG476_RS03625	COG0475	glutathione-regulated potassium exporter activity
CG476_RS03625	COG0569	domain protein
CG476_RS03640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CG476_RS03645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CG476_RS03650	COG0833	amino acid
CG476_RS03655	COG4990	cell redox homeostasis
CG476_RS03670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_RS03675	COG0697	spore germination
CG476_RS03680	COG0531	amino acid
CG476_RS03690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG476_RS03695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG476_RS03700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG476_RS03700	COG1918	ferrous iron import across plasma membrane
CG476_RS03705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG476_RS03710	COG0573	inorganic phosphate transmembrane transporter activity
CG476_RS03720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG476_RS03760	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG476_RS03845	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CG476_RS03870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG476_RS03875	COG1116	anion transmembrane transporter activity
CG476_RS03880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG476_RS03885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG476_RS03890	COG0352	thiamine-phosphate diphosphorylase activity
CG476_RS03895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG476_RS03900	COG2104	thiamine diphosphate biosynthetic process
CG476_RS03905	COG2022	thiamine diphosphate biosynthetic process
CG476_RS03910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG476_RS03915	COG0351	phosphomethylpyrimidine kinase
CG476_RS03945	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CG476_RS03950	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CG476_RS03955	COG2205	protein histidine kinase activity
CG476_RS03965	COG4974	Belongs to the 'phage' integrase family
CG476_RS03975	COG2816	NAD+ diphosphatase activity
CG476_RS03985	COG0735	belongs to the Fur family
CG476_RS04010	COG1846	Transcriptional regulator
CG476_RS04020	COG2252	PERMEase
CG476_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS04030	COG1376	ErfK ybiS ycfS ynhG family protein
CG476_RS04085	COG0778	Nitroreductase
CG476_RS04095	COG2719	SpoVR family
CG476_RS04105	COG1316	TRANSCRIPTIONal
CG476_RS04110	COG1283	sodium-dependent phosphate transmembrane transporter activity
CG476_RS04125	COG0577	efflux transmembrane transporter activity
CG476_RS04130	COG1136	(ABC) transporter
CG476_RS04140	COG1114	Component of the transport system for branched-chain amino acids
CG476_RS04145	COG3546	catalase activity
CG476_RS04195	COG0475	glutathione-regulated potassium exporter activity
CG476_RS04200	COG1737	Transcriptional regulator
CG476_RS04210	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CG476_RS04215	COG1263	PTS System
CG476_RS04215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG476_RS04260	COG1522	sequence-specific DNA binding
CG476_RS04275	COG0531	amino acid
CG476_RS04285	COG1012	belongs to the aldehyde dehydrogenase family
CG476_RS04295	COG1132	(ABC) transporter
CG476_RS04300	COG1132	(ABC) transporter
CG476_RS04310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG476_RS04315	COG0765	amino acid transport
CG476_RS04320	COG1126	abc transporter atp-binding protein
CG476_RS04335	COG0189	ligase activity
CG476_RS04340	COG4399	Belongs to the UPF0754 family
CG476_RS04345	COG3679	Belongs to the UPF0342 family
CG476_RS04350	COG4585	Histidine kinase
CG476_RS04355	COG2197	response regulator
CG476_RS04415	COG2094	Belongs to the DNA glycosylase MPG family
CG476_RS04420	COG0561	phosphatase activity
CG476_RS04430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG476_RS04435	COG0318	PFAM AMP-dependent synthetase and ligase
CG476_RS04460	COG2244	polysaccharide biosynthetic process
CG476_RS04470	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG476_RS04490	COG1696	Membrane protein involved in D-alanine export
CG476_RS04505	COG1024	Enoyl-CoA hydratase
CG476_RS04515	COG1363	Peptidase, m42
CG476_RS04530	COG2239	Acts as a magnesium transporter
CG476_RS04535	COG0772	Belongs to the SEDS family
CG476_RS04540	COG1115	amino acid carrier protein
CG476_RS04650	COG1476	TRANSCRIPTIONal
CG476_RS04690	COG1131	(ABC) transporter
CG476_RS04735	COG0494	nUDIX hydrolase
CG476_RS04750	COG1061	Type III restriction enzyme res subunit
CG476_RS04760	COG3829	transcription factor binding
CG476_RS04765	COG4638	Rieske (2fe-2S)
CG476_RS04770	COG1012	belongs to the aldehyde dehydrogenase family
CG476_RS04775	COG0473	3-isopropylmalate dehydrogenase activity
CG476_RS04785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_RS04795	COG1064	alcohol dehydrogenase
CG476_RS04810	COG3246	L-lysine catabolic process to acetate
CG476_RS04855	COG4641	Protein conserved in bacteria
CG476_RS04870	COG3711	transcriptional antiterminator
CG476_RS04875	COG2190	(PTS) system
CG476_RS04875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG476_RS04875	COG1263	PTS System
CG476_RS04880	COG2723	6-phospho-beta-galactosidase activity
CG476_RS04890	COG2376	Dihydroxyacetone kinase
CG476_RS04925	COG0420	3'-5' exonuclease activity
CG476_RS04930	COG4717	serine-type aminopeptidase activity
CG476_RS04935	COG3481	metal-dependent phosphohydrolase, HD sub domain
CG476_RS04950	COG0577	efflux transmembrane transporter activity
CG476_RS04955	COG1136	(ABC) transporter
CG476_RS04960	COG5002	protein histidine kinase activity
CG476_RS04965	COG0745	RESPONSE REGULATOR receiver
CG476_RS04975	COG1316	TRANSCRIPTIONal
CG476_RS04990	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CG476_RS04995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG476_RS05000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CG476_RS05005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CG476_RS05030	COG1846	Transcriptional regulator
CG476_RS05035	COG4980	gas vesicle protein
CG476_RS05045	COG0537	adenosine 5'-monophosphoramidase activity
CG476_RS05055	COG1131	(ABC) transporter
CG476_RS05060	COG4473	ABC transporter
CG476_RS05080	COG3402	PFAM membrane-flanked domain
CG476_RS05090	COG2329	Antibiotic biosynthesis monooxygenase
CG476_RS05095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG476_RS05100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CG476_RS05105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CG476_RS05110	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CG476_RS05140	COG1309	transcriptional regulator
CG476_RS05150	COG1216	Glycosyl transferase, family 2
CG476_RS05150	COG0438	transferase activity, transferring glycosyl groups
CG476_RS05160	COG1609	Transcriptional regulator
CG476_RS05170	COG1234	tRNA 3'-trailer cleavage
CG476_RS05175	COG0095	Lipoate-protein ligase
CG476_RS05185	COG0318	PFAM AMP-dependent synthetase and ligase
CG476_RS05200	COG2205	protein histidine kinase activity
CG476_RS05205	COG0745	RESPONSE REGULATOR receiver
CG476_RS05225	COG0501	Belongs to the peptidase M48B family
CG476_RS05230	COG0840	transmembrane signaling receptor activity
CG476_RS05235	COG0697	spore germination
CG476_RS05250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CG476_RS05255	COG2224	Isocitrate lyase
CG476_RS05260	COG1278	Cold shock
CG476_RS05265	COG4903	ComK protein
CG476_RS05270	COG0398	Pfam SNARE associated Golgi protein
CG476_RS05280	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CG476_RS05285	COG1074	ATP-dependent DNA helicase activity
CG476_RS05325	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG476_RS05345	COG0367	asparagine synthase
CG476_RS05355	COG0753	catalase activity
CG476_RS05365	COG1874	Beta-galactosidase
CG476_RS05365	COG0366	Alpha amylase catalytic
CG476_RS05370	COG1666	GTP binding
CG476_RS05375	COG2996	Protein conserved in bacteria
CG476_RS05390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_RS05405	COG0561	phosphatase activity
CG476_RS05425	COG2267	carboxylic ester hydrolase activity
CG476_RS05440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG476_RS05445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CG476_RS05450	COG5504	Zn-dependent protease
CG476_RS05465	COG0180	Tryptophanyl-tRNA synthetase
CG476_RS05485	COG4166	transmembrane transport
CG476_RS05490	COG0601	transmembrane transport
CG476_RS05495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG476_RS05500	COG0444	Belongs to the ABC transporter superfamily
CG476_RS05505	COG4608	Belongs to the ABC transporter superfamily
CG476_RS05510	COG0534	Mate efflux family protein
CG476_RS05515	COG4166	transmembrane transport
CG476_RS05535	COG0861	Integral membrane protein TerC family
CG476_RS05555	COG1164	Oligoendopeptidase f
CG476_RS05565	COG2346	COG2346, Truncated hemoglobins
CG476_RS05570	COG4116	CYTH
CG476_RS05580	COG2357	RelA SpoT domain protein
CG476_RS05590	COG0564	pseudouridine synthase activity
CG476_RS05600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG476_RS05605	COG0772	Belongs to the SEDS family
CG476_RS05650	COG1216	Glycosyl transferase, family 2
CG476_RS05670	COG0463	Glycosyl transferase, family 2
CG476_RS05670	COG0457	Tetratricopeptide repeat
CG476_RS05690	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CG476_RS05705	COG1091	dTDP-4-dehydrorhamnose reductase activity
CG476_RS05730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CG476_RS05735	COG2382	esterase
CG476_RS05750	COG5492	domain, Protein
CG476_RS05755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_RS05770	COG1620	l-lactate permease
CG476_RS05775	COG5634	Uncharacterized conserved protein (DUF2278)
CG476_RS05815	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG476_RS05820	COG0567	Dehydrogenase, E1 component
CG476_RS05830	COG0583	DNA-binding transcription factor activity
CG476_RS05835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG476_RS05840	COG1012	belongs to the aldehyde dehydrogenase family
CG476_RS05855	COG0196	riboflavin kinase activity
CG476_RS05860	COG3162	membrane
CG476_RS05865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_RS05870	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG476_RS05885	COG0457	Tetratricopeptide repeat
CG476_RS05950	COG0673	inositol 2-dehydrogenase activity
CG476_RS05980	COG0457	Tetratricopeptide repeat
CG476_RS05985	COG0582	viral genome integration into host DNA
CG476_RS06040	COG0582	viral genome integration into host DNA
CG476_RS06065	COG1686	Belongs to the peptidase S11 family
CG476_RS06070	COG0681	Belongs to the peptidase S26 family
CG476_RS06105	COG1012	belongs to the aldehyde dehydrogenase family
CG476_RS06115	COG1176	ABC-type spermidine putrescine transport system, permease component I
CG476_RS06120	COG1177	transmembrane transport
CG476_RS06125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CG476_RS06130	COG0671	phosphoesterase, PA-phosphatase related
CG476_RS06135	COG2409	Drug exporters of the RND superfamily
CG476_RS06145	COG0564	pseudouridine synthase activity
CG476_RS06155	COG2340	Cysteine-rich secretory protein family
CG476_RS06160	COG0247	lactate metabolic process
CG476_RS06165	COG0277	FAD linked oxidase domain protein
CG476_RS06170	COG3835	regulator
CG476_RS06180	COG0745	RESPONSE REGULATOR receiver
CG476_RS06185	COG5002	protein histidine kinase activity
CG476_RS06190	COG2186	Transcriptional regulator
CG476_RS06195	COG0247	lactate metabolic process
CG476_RS06200	COG1139	Iron-sulfur cluster binding protein
CG476_RS06205	COG1556	Lactate utilization protein
CG476_RS06210	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CG476_RS06215	COG0584	glycerophosphoryl diester phosphodiesterase
CG476_RS06230	COG2267	carboxylic ester hydrolase activity
CG476_RS06235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG476_RS06260	COG2116	formate transmembrane transporter activity
CG476_RS06265	COG0861	Integral membrane protein TerC family
CG476_RS06270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG476_RS06280	COG2030	dehydratase
CG476_RS06300	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS06305	COG3243	poly(R)-hydroxyalkanoic acid synthase
CG476_RS06310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG476_RS06325	COG1840	ABC-type Fe3 transport system, periplasmic component
CG476_RS06330	COG3842	ATPase activity
CG476_RS06340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG476_RS06345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CG476_RS06350	COG1349	DNA-binding transcription factor activity
CG476_RS06355	COG0235	Class ii aldolase
CG476_RS06365	COG2861	carbohydrate metabolic process
CG476_RS06375	COG3852	Histidine kinase
CG476_RS06380	COG1846	Transcriptional regulator
CG476_RS06400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CG476_RS06405	COG0720	synthase
CG476_RS06415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CG476_RS06420	COG4873	Protein conserved in bacteria
CG476_RS06430	COG0456	acetyltransferase
CG476_RS06450	COG1780	Probably involved in ribonucleotide reductase function
CG476_RS06470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CG476_RS06475	COG1725	Transcriptional regulator
CG476_RS06480	COG1131	(ABC) transporter
CG476_RS06490	COG1131	(ABC) transporter
CG476_RS06495	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG476_RS06510	COG1522	sequence-specific DNA binding
CG476_RS06525	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG476_RS06530	COG2070	2-Nitropropane dioxygenase
CG476_RS06535	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CG476_RS06545	COG1696	Membrane protein involved in D-alanine export
CG476_RS06550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG476_RS06565	COG0716	FMN binding
CG476_RS06590	COG1368	sulfuric ester hydrolase activity
CG476_RS06600	COG3173	Aminoglycoside phosphotransferase
CG476_RS06610	COG5609	conserved protein (DUF2294)
CG476_RS06615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG476_RS06620	COG3002	Belongs to the UPF0753 family
CG476_RS06625	COG0288	reversible hydration of carbon dioxide
CG476_RS06630	COG0534	Mate efflux family protein
CG476_RS06645	COG1846	Transcriptional regulator
CG476_RS06655	COG1301	dicarboxylic acid transport
CG476_RS06660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG476_RS06670	COG3874	Sporulation protein YtfJ
CG476_RS06700	COG0028	Belongs to the TPP enzyme family
CG476_RS06705	COG0440	acetolactate synthase activity
CG476_RS06710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CG476_RS06715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG476_RS06725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CG476_RS06730	COG0066	3-isopropylmalate dehydratase activity
CG476_RS06740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CG476_RS06750	COG0131	Imidazoleglycerol-phosphate dehydratase
CG476_RS06755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CG476_RS06760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CG476_RS06765	COG0107	imidazoleglycerol-phosphate synthase activity
CG476_RS06770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CG476_RS06775	COG0140	phosphoribosyl-ATP diphosphatase activity
CG476_RS06790	COG1183	phosphatidylcholine synthase activity
CG476_RS06795	COG1368	sulfuric ester hydrolase activity
CG476_RS06805	COG0019	diaminopimelate decarboxylase activity
CG476_RS06815	COG0175	sulfate reduction
CG476_RS06820	COG2046	Belongs to the sulfate adenylyltransferase family
CG476_RS06825	COG0529	Catalyzes the synthesis of activated sulfate
CG476_RS06830	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG476_RS06850	COG1648	precorrin-2 dehydrogenase activity
CG476_RS06850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG476_RS06855	COG0733	neurotransmitter:sodium symporter activity
CG476_RS06870	COG3557	Belongs to the UPF0374 family
CG476_RS06875	COG1757	Na H antiporter
CG476_RS06890	COG4758	membrane
CG476_RS06895	COG4585	Histidine kinase
CG476_RS06900	COG2197	response regulator
CG476_RS06905	COG1114	Component of the transport system for branched-chain amino acids
CG476_RS06910	COG0737	Belongs to the 5'-nucleotidase family
CG476_RS06910	COG1525	nuclease
CG476_RS06910	COG4085	toxin activity
CG476_RS06940	COG3711	transcriptional antiterminator
CG476_RS06950	COG2723	6-phospho-beta-galactosidase activity
CG476_RS06965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_RS06965	COG3711	transcriptional antiterminator
CG476_RS06970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG476_RS06970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_RS06970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG476_RS06975	COG1482	cell wall glycoprotein biosynthetic process
CG476_RS06985	COG2801	Transposase and inactivated derivatives
CG476_RS07005	COG0730	response to heat
CG476_RS07010	COG0306	phosphate transporter
CG476_RS07015	COG1392	Phosphate transport regulator
CG476_RS07020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG476_RS07030	COG3852	Histidine kinase
CG476_RS07035	COG1801	Protein of unknown function DUF72
CG476_RS07045	COG0582	viral genome integration into host DNA
CG476_RS07050	COG5002	protein histidine kinase activity
CG476_RS07055	COG0813	purine-nucleoside phosphorylase activity
CG476_RS07065	COG0392	lysyltransferase activity
CG476_RS07065	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CG476_RS07080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG476_RS07085	COG1686	Belongs to the peptidase S11 family
CG476_RS07090	COG2715	membrane protein required for spore maturation
CG476_RS07095	COG0700	Nucleoside recognition
CG476_RS07100	COG1187	pseudouridine synthase activity
CG476_RS07110	COG1333	cytochrome c biogenesis protein
CG476_RS07115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG476_RS07120	COG0745	RESPONSE REGULATOR receiver
CG476_RS07125	COG5002	protein histidine kinase activity
CG476_RS07130	COG2096	Adenosyltransferase
CG476_RS07150	COG1141	Ferredoxin
CG476_RS07160	COG0514	ATP-dependent DNA helicase (RecQ)
CG476_RS07165	COG1266	CAAX protease self-immunity
CG476_RS07175	COG1408	metallophosphoesterase
CG476_RS07190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG476_RS07205	COG0492	ferredoxin-NADP+ reductase activity
CG476_RS07215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CG476_RS07225	COG1304	FMN binding
CG476_RS07260	COG1160	GTP binding
CG476_RS07265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CG476_RS07285	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG476_RS07295	COG0302	gtp cyclohydrolase
CG476_RS07300	COG0142	geranyltranstransferase activity
CG476_RS07305	COG2226	methyltransferase
CG476_RS07310	COG0142	geranyltranstransferase activity
CG476_RS07320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CG476_RS07325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CG476_RS07330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CG476_RS07335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CG476_RS07340	COG0457	Tetratricopeptide repeat
CG476_RS07345	COG5582	Belongs to the UPF0302 family
CG476_RS07360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CG476_RS07370	COG4347	Protein of unknown function (DUF1405)
CG476_RS07385	COG2738	Putative neutral zinc metallopeptidase
CG476_RS07395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_RS07400	COG1694	Mazg nucleotide pyrophosphohydrolase
CG476_RS07405	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CG476_RS07410	COG1803	Methylglyoxal synthase
CG476_RS07415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG476_RS07420	COG0438	transferase activity, transferring glycosyl groups
CG476_RS07425	COG0617	tRNA 3'-terminal CCA addition
CG476_RS07440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CG476_RS07445	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CG476_RS07450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CG476_RS07455	COG1199	ATP-dependent helicase activity
CG476_RS07455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CG476_RS07475	COG3935	DnaD domain protein
CG476_RS07480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CG476_RS07490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG476_RS07490	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG476_RS07495	COG3331	DNA recombination
CG476_RS07530	COG4474	Belongs to the UPF0398 family
CG476_RS07535	COG3599	regulation of cell shape
CG476_RS07545	COG0116	Belongs to the methyltransferase superfamily
CG476_RS07555	COG1199	ATP-dependent helicase activity
CG476_RS07560	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CG476_RS07570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG476_RS07575	COG2233	PERMEase
CG476_RS07580	COG2311	Membrane
CG476_RS07585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG476_RS07595	COG0456	acetyltransferase
CG476_RS07635	COG3766	membrane
CG476_RS07645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG476_RS07650	COG1733	regulation of RNA biosynthetic process
CG476_RS07670	COG0328	RNA-DNA hybrid ribonuclease activity
CG476_RS07700	COG1278	Cold shock
CG476_RS07710	COG3162	membrane
CG476_RS07715	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_RS07720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG476_RS07725	COG0475	glutathione-regulated potassium exporter activity
CG476_RS07760	COG2323	membrane
CG476_RS07765	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CG476_RS07790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG476_RS07800	COG2201	protein-glutamate methylesterase activity
CG476_RS07805	COG0643	Histidine kinase
CG476_RS07805	COG2198	Histidine kinase
CG476_RS07810	COG1776	CheC inhibitor of MCP methylation
CG476_RS07810	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG476_RS07825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CG476_RS07845	COG1256	bacterial-type flagellum assembly
CG476_RS07850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG476_RS07855	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CG476_RS07870	COG1815	bacterial-type flagellum-dependent cell motility
CG476_RS07890	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG476_RS07900	COG1157	protein secretion by the type III secretion system
CG476_RS07935	COG0835	chemotaxis
CG476_RS07935	COG0784	Response regulator, receiver
CG476_RS07945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG476_RS07950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG476_RS07955	COG0741	lytic transglycosylase activity
CG476_RS07965	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG476_RS07970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG476_RS07970	COG1776	CheC inhibitor of MCP methylation
CG476_RS07980	COG1338	Plays a role in the flagellum-specific transport system
CG476_RS07985	COG1987	bacterial-type flagellum assembly
CG476_RS07995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG476_RS08000	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG476_RS08005	COG1419	protein localization to endoplasmic reticulum
CG476_RS08010	COG4786	Flagellar basal body rod
CG476_RS08015	COG1136	(ABC) transporter
CG476_RS08015	COG0577	efflux transmembrane transporter activity
CG476_RS08065	COG2814	Major facilitator Superfamily
CG476_RS08110	COG0367	asparagine synthase
CG476_RS08130	COG1802	Transcriptional regulator
CG476_RS08135	COG0697	spore germination
CG476_RS08145	COG1757	Na H antiporter
CG476_RS08180	COG0534	Mate efflux family protein
CG476_RS08185	COG3340	Belongs to the peptidase S51 family
CG476_RS08190	COG2733	membrane
CG476_RS08200	COG1280	lysine exporter protein (LysE YggA)
CG476_RS08205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG476_RS08220	COG2502	aspartate--ammonia ligase
CG476_RS08230	COG0109	protoheme IX farnesyltransferase activity
CG476_RS08260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG476_RS08265	COG0488	(ABC) transporter
CG476_RS08270	COG4166	transmembrane transport
CG476_RS08275	COG2223	nitrite transmembrane transporter activity
CG476_RS08280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG476_RS08285	COG2244	polysaccharide biosynthetic process
CG476_RS08290	COG0733	neurotransmitter:sodium symporter activity
CG476_RS08295	COG5566	PFAM Mor transcription activator
CG476_RS08310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG476_RS08315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG476_RS08330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CG476_RS08360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG476_RS08365	COG2814	Major facilitator Superfamily
CG476_RS08370	COG3384	dioxygenase
CG476_RS08390	COG0402	S-adenosylhomocysteine deaminase activity
CG476_RS08395	COG4166	transmembrane transport
CG476_RS08405	COG1914	H( )-stimulated, divalent metal cation uptake system
CG476_RS08410	COG1054	Belongs to the UPF0176 family
CG476_RS08420	COG0083	homoserine kinase activity
CG476_RS08430	COG2390	Transcriptional regulator
CG476_RS08435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CG476_RS08450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG476_RS08460	COG1510	regulation of RNA biosynthetic process
CG476_RS08465	COG1012	belongs to the aldehyde dehydrogenase family
CG476_RS08470	COG1454	alcohol dehydrogenase
CG476_RS08485	COG1012	belongs to the aldehyde dehydrogenase family
CG476_RS08490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CG476_RS08500	COG0628	permease
CG476_RS08515	COG0523	cobalamin synthesis protein
CG476_RS08540	COG1686	Belongs to the peptidase S11 family
CG476_RS08555	COG0791	NLP P60 protein
CG476_RS08555	COG1388	LysM domain
CG476_RS08560	COG0300	oxidoreductase activity
CG476_RS08570	COG0460	homoserine dehydrogenase
CG476_RS08580	COG0083	homoserine kinase activity
CG476_RS08585	COG1316	TRANSCRIPTIONal
CG476_RS08600	COG1285	pathogenesis
CG476_RS08605	COG1247	-acetyltransferase
CG476_RS08620	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG476_RS08640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CG476_RS08645	COG0577	efflux transmembrane transporter activity
CG476_RS08650	COG2409	Drug exporters of the RND superfamily
CG476_RS08655	COG1404	Belongs to the peptidase S8 family
CG476_RS08670	COG0840	transmembrane signaling receptor activity
CG476_RS08685	COG3949	Membrane
CG476_RS08690	COG0783	Belongs to the Dps family
CG476_RS08710	COG0523	cobalamin synthesis protein
CG476_RS08720	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG476_RS08735	COG1902	pentaerythritol trinitrate reductase activity
CG476_RS08740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CG476_RS08750	COG4166	transmembrane transport
CG476_RS08755	COG0346	lactoylglutathione lyase activity
CG476_RS08765	COG5337	Spore coat protein CotH
CG476_RS08770	COG1051	belongs to the nudix hydrolase family
CG476_RS08775	COG0586	Pfam SNARE associated Golgi protein
CG476_RS08780	COG2244	polysaccharide biosynthetic process
CG476_RS08790	COG0701	Predicted permease
CG476_RS08795	COG3689	TIGRFAM TIGR03943 family protein
CG476_RS08800	COG1607	acyl-coa hydrolase
CG476_RS08810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG476_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS08830	COG2839	Protein conserved in bacteria
CG476_RS08835	COG1253	flavin adenine dinucleotide binding
CG476_RS08875	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG476_RS08885	COG1876	peptidase activity
CG476_RS08940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CG476_RS08945	COG1819	glycosyl
CG476_RS08950	COG1819	glycosyl
CG476_RS08955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG476_RS09005	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG476_RS09060	COG3874	Sporulation protein YtfJ
CG476_RS09085	COG2226	methyltransferase
CG476_RS09110	COG0386	Belongs to the glutathione peroxidase family
CG476_RS09140	COG0640	Transcriptional regulator
CG476_RS09145	COG0798	PFAM Bile acid sodium symporter
CG476_RS09150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG476_RS09195	COG1418	mRNA catabolic process
CG476_RS09200	COG0488	(ABC) transporter
CG476_RS09210	COG0629	single-stranded DNA binding
CG476_RS09215	COG1413	lyase activity
CG476_RS09230	COG2521	methyltransferase
CG476_RS09230	COG2136	Putative SAM-dependent methyltransferase
CG476_RS09235	COG0018	arginyl-trna synthetase
CG476_RS09245	COG0733	neurotransmitter:sodium symporter activity
CG476_RS09250	COG0596	Alpha beta hydrolase
CG476_RS09270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG476_RS09275	COG0477	Major facilitator Superfamily
CG476_RS09300	COG2610	gluconate transmembrane transporter activity
CG476_RS09310	COG0456	acetyltransferase
CG476_RS09315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CG476_RS09325	COG1131	(ABC) transporter
CG476_RS09330	COG4473	ABC transporter
CG476_RS09345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG476_RS09350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CG476_RS09360	COG0768	penicillin binding
CG476_RS09370	COG0204	Acyl-transferase
CG476_RS09375	COG1272	protein, Hemolysin III
CG476_RS09380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CG476_RS09385	COG0805	protein transport
CG476_RS09395	COG1307	EDD domain protein, DegV family
CG476_RS09405	COG1999	signal sequence binding
CG476_RS09410	COG0071	Belongs to the small heat shock protein (HSP20) family
CG476_RS09415	COG0367	asparagine synthase
CG476_RS09430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG476_RS09455	COG0071	Belongs to the small heat shock protein (HSP20) family
CG476_RS09465	COG1737	Transcriptional regulator
CG476_RS09470	COG1070	Carbohydrate kinase
CG476_RS09480	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CG476_RS09535	COG1151	hydroxylamine reductase activity
CG476_RS09545	COG1253	flavin adenine dinucleotide binding
CG476_RS09550	COG5506	Protein of unknown function (DUF1694)
CG476_RS09570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG476_RS09575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CG476_RS09580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CG476_RS09585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG476_RS09590	COG0456	acetyltransferase
CG476_RS09595	COG3829	transcription factor binding
CG476_RS09605	COG1509	lysine 2,3-aminomutase activity
CG476_RS09615	COG4479	Belongs to the UPF0346 family
CG476_RS09640	COG1357	PFAM Pentapeptide repeats (8 copies)
CG476_RS09640	COG0515	serine threonine protein kinase
CG476_RS09645	COG0671	phosphoesterase, PA-phosphatase related
CG476_RS09650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG476_RS09655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG476_RS09705	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CG476_RS09715	COG0726	polysaccharide deacetylase
CG476_RS09720	COG1408	metallophosphoesterase
CG476_RS09725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG476_RS09730	COG2323	membrane
CG476_RS09735	COG0671	phosphoesterase, PA-phosphatase related
CG476_RS09745	COG1280	lysine exporter protein (LysE YggA)
CG476_RS09750	COG3403	YqcI/YcgG family
CG476_RS09780	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG476_RS09780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG476_RS09790	COG0372	Belongs to the citrate synthase family
CG476_RS09795	COG2079	MmgE PrpD family protein
CG476_RS09800	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CG476_RS09805	COG1960	acyl-CoA dehydrogenase activity
CG476_RS09810	COG2084	Dehydrogenase
CG476_RS09815	COG1012	belongs to the aldehyde dehydrogenase family
CG476_RS09825	COG1280	lysine exporter protein (LysE YggA)
CG476_RS09845	COG0420	3'-5' exonuclease activity
CG476_RS09850	COG0419	ATPase involved in DNA repair
CG476_RS09855	COG3104	oligopeptide transport
CG476_RS09890	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG476_RS09895	COG1131	(ABC) transporter
CG476_RS09915	COG1131	(ABC) transporter
CG476_RS09920	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG476_RS09940	COG1942	4-Oxalocrotonate Tautomerase
CG476_RS09975	COG0457	Tetratricopeptide repeat
CG476_RS10010	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS10015	COG1169	isochorismate synthase
CG476_RS10020	COG1021	2,3-dihydroxybenzoate-AMP ligase
CG476_RS10025	COG1535	isochorismatase
CG476_RS10025	COG3433	isochorismatase activity
CG476_RS10030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG476_RS10035	COG3251	PFAM MbtH domain protein
CG476_RS10040	COG2814	Major facilitator Superfamily
CG476_RS10055	COG0776	regulation of translation
CG476_RS10070	COG2329	Antibiotic biosynthesis monooxygenase
CG476_RS10075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG476_RS10115	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG476_RS10120	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CG476_RS10125	COG0667	Aldo Keto reductase
CG476_RS10145	COG0010	Belongs to the arginase family
CG476_RS10155	COG1132	(ABC) transporter
CG476_RS10160	COG1132	(ABC) transporter
CG476_RS10165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG476_RS10190	COG1649	PFAM Uncharacterised BCR, COG1649
CG476_RS10210	COG2971	BadF BadG BcrA BcrD
CG476_RS10230	COG0588	phosphoglycerate mutase activity
CG476_RS10265	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG476_RS10275	COG1960	acyl-CoA dehydrogenase activity
CG476_RS10280	COG0439	Biotin carboxylase
CG476_RS10285	COG0511	ligase activity, forming carbon-carbon bonds
CG476_RS10290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG476_RS10295	COG1024	Enoyl-CoA hydratase
CG476_RS10300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CG476_RS10305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG476_RS10315	COG1216	Glycosyl transferase, family 2
CG476_RS10320	COG0640	Transcriptional regulator
CG476_RS10330	COG1686	Belongs to the peptidase S11 family
CG476_RS10335	COG5002	protein histidine kinase activity
CG476_RS10365	COG0789	Transcriptional regulator
CG476_RS10385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG476_RS10395	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS10415	COG0475	glutathione-regulated potassium exporter activity
CG476_RS10435	COG1309	transcriptional regulator
CG476_RS10445	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS10450	COG2002	toxin-antitoxin pair type II binding
CG476_RS10470	COG0693	protein deglycase activity
CG476_RS10475	COG0201	protein transport
CG476_RS10495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG476_RS10500	COG0322	excinuclease ABC activity
CG476_RS10505	COG2318	DinB family
CG476_RS10515	COG4667	esterase of the alpha-beta hydrolase superfamily
CG476_RS10535	COG1051	belongs to the nudix hydrolase family
CG476_RS10585	COG2223	nitrite transmembrane transporter activity
CG476_RS10630	COG1216	Glycosyl transferase, family 2
CG476_RS10645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG476_RS10650	COG1279	arginine transmembrane transporter activity
CG476_RS10685	COG1794	racemase activity, acting on amino acids and derivatives
CG476_RS10695	COG2828	Protein conserved in bacteria
CG476_RS10700	COG5002	protein histidine kinase activity
CG476_RS10705	COG0561	phosphatase activity
CG476_RS10725	COG2124	cytochrome p450
CG476_RS10760	COG0457	Tetratricopeptide repeat
CG476_RS10770	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG476_RS10800	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG476_RS10805	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_RS10810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG476_RS10820	COG2959	enzyme of heme biosynthesis
CG476_RS10850	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CG476_RS10855	COG3844	kynureninase activity
CG476_RS10865	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS10875	COG4176	ABC-type proline glycine betaine transport system permease component
CG476_RS10880	COG0517	IMP dehydrogenase activity
CG476_RS10880	COG4175	Glycine betaine
CG476_RS10910	COG2153	protein acetylation
CG476_RS10940	COG0514	ATP-dependent DNA helicase (RecQ)
CG476_RS10960	COG4637	Psort location Cytoplasmic, score
CG476_RS10965	COG1227	inorganic diphosphatase activity
CG476_RS10975	COG3397	chitin binding
CG476_RS11015	COG4166	transmembrane transport
CG476_RS11025	COG4948	Mandelate Racemase Muconate Lactonizing
CG476_RS11105	COG1307	EDD domain protein, DegV family
CG476_RS11150	COG5444	nuclease activity
CG476_RS11250	COG5444	nuclease activity
CG476_RS11270	COG2261	transglycosylase associated protein
CG476_RS11275	COG0675	Transposase, IS605 OrfB family
CG476_RS11300	COG0436	Aminotransferase
CG476_RS11315	COG3973	AAA domain
CG476_RS11325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG476_RS11350	COG0628	permease
CG476_RS11365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG476_RS11370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG476_RS11375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG476_RS11390	COG2746	aminoglycoside 3-N-acetyltransferase activity
CG476_RS11400	COG0456	acetyltransferase
CG476_RS11400	COG0454	-acetyltransferase
CG476_RS11425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_RS11430	COG1368	sulfuric ester hydrolase activity
CG476_RS11435	COG0488	(ABC) transporter
CG476_RS11440	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG476_RS11440	COG1605	Chorismate mutase
CG476_RS11460	COG0346	lactoylglutathione lyase activity
CG476_RS11470	COG3547	Transposase (IS116 IS110 IS902 family)
CG476_RS11475	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG476_RS11515	COG2329	Antibiotic biosynthesis monooxygenase
CG476_RS11530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG476_RS11555	COG0494	nUDIX hydrolase
CG476_RS11570	COG0456	acetyltransferase
CG476_RS11575	COG0477	Major facilitator Superfamily
CG476_RS11590	COG0697	spore germination
CG476_RS11595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG476_RS11605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG476_RS11620	COG0730	response to heat
CG476_RS11630	COG0833	amino acid
CG476_RS11655	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CG476_RS11670	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CG476_RS11675	COG1984	allophanate hydrolase subunit 2
CG476_RS11680	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CG476_RS11685	COG1414	Transcriptional regulator
CG476_RS11700	COG1960	acyl-CoA dehydrogenase activity
CG476_RS11715	COG3314	Sporulation integral membrane protein YlbJ
CG476_RS11730	COG0346	lactoylglutathione lyase activity
CG476_RS11740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG476_RS11745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CG476_RS11750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG476_RS11755	COG0438	transferase activity, transferring glycosyl groups
CG476_RS11770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG476_RS11775	COG0438	transferase activity, transferring glycosyl groups
CG476_RS11780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG476_RS11795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CG476_RS11815	COG4851	CamS sex pheromone cAM373 precursor
CG476_RS11930	COG0477	Major facilitator Superfamily
CG476_RS11945	COG1846	Transcriptional regulator
CG476_RS11950	COG2814	Major facilitator Superfamily
CG476_RS11960	COG2031	fatty acid transporter
CG476_RS11995	COG1122	ATPase activity
CG476_RS12020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CG476_RS12035	COG1131	(ABC) transporter
CG476_RS12055	COG2365	Tyrosine phosphatase family
CG476_RS12095	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CG476_RS12100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_RS12105	COG0579	oxidoreductase
CG476_RS12110	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CG476_RS12120	COG1253	flavin adenine dinucleotide binding
CG476_RS12125	COG0789	Transcriptional regulator
CG476_RS12130	COG3813	Protein conserved in bacteria
CG476_RS12205	COG0582	viral genome integration into host DNA
CG476_RS12310	COG2072	flavoprotein involved in K transport
CG476_RS12340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG476_RS12345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG476_RS12355	COG1193	negative regulation of DNA recombination
CG476_RS12360	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CG476_RS12365	COG1164	Oligoendopeptidase f
CG476_RS12385	COG0584	glycerophosphoryl diester phosphodiesterase
CG476_RS12390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG476_RS12420	COG3397	chitin binding
CG476_RS12435	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CG476_RS12440	COG0277	FAD linked oxidase domain protein
CG476_RS12445	COG1285	pathogenesis
CG476_RS12450	COG2720	vancomycin resistance protein
CG476_RS12655	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CG476_RS12760	COG1484	DNA-dependent DNA replication
CG476_RS12810	COG0582	viral genome integration into host DNA
CG476_RS12835	COG1278	Cold shock
CG476_RS12845	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS12850	COG0165	Argininosuccinate lyase
CG476_RS12865	COG3409	Peptidoglycan-binding domain 1 protein
CG476_RS12880	COG4145	pantothenate transmembrane transporter activity
CG476_RS12885	COG3924	membrane
CG476_RS12890	COG1012	belongs to the aldehyde dehydrogenase family
CG476_RS12900	COG1657	PFAM Prenyltransferase squalene oxidase
CG476_RS12905	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CG476_RS12910	COG2962	Rard protein
CG476_RS12945	COG2226	methyltransferase
CG476_RS12950	COG4166	transmembrane transport
CG476_RS12955	COG4166	transmembrane transport
CG476_RS12960	COG1301	dicarboxylic acid transport
CG476_RS12970	COG0673	inositol 2-dehydrogenase activity
CG476_RS12975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG476_RS12980	COG0187	DNA topoisomerase II activity
CG476_RS12990	COG1832	CoA-binding protein
CG476_RS12995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG476_RS13000	COG0745	RESPONSE REGULATOR receiver
CG476_RS13015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CG476_RS13020	COG4841	protein insertion into membrane
CG476_RS13030	COG0824	Thioesterase
CG476_RS13060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG476_RS13065	COG3655	Transcriptional regulator
CG476_RS13085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CG476_RS13125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG476_RS13130	COG0318	PFAM AMP-dependent synthetase and ligase
CG476_RS13160	COG0457	Tetratricopeptide repeat
CG476_RS13240	COG2826	transposase and inactivated derivatives, IS30 family
CG476_RS13255	COG0534	Mate efflux family protein
CG476_RS13285	COG3023	N-Acetylmuramoyl-L-alanine amidase
CG476_RS13295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_RS13305	COG5002	protein histidine kinase activity
CG476_RS13310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_RS13315	COG0010	Belongs to the arginase family
CG476_RS13320	COG1228	amidohydrolase
CG476_RS13325	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CG476_RS13330	COG2986	histidine ammonia-lyase
CG476_RS13350	COG4846	Membrane protein involved in cytochrome C biogenesis
CG476_RS13355	COG0785	Cytochrome C biogenesis protein
CG476_RS13370	COG0583	DNA-binding transcription factor activity
CG476_RS13375	COG1380	Effector of murein hydrolase LrgA
CG476_RS13380	COG1346	cytolysis
CG476_RS13385	COG4187	Peptidase family M20/M25/M40
CG476_RS13395	COG0833	amino acid
CG476_RS13405	COG0730	response to heat
CG476_RS13415	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG476_RS13415	COG3409	Peptidoglycan-binding domain 1 protein
CG476_RS13430	COG1132	(ABC) transporter
CG476_RS13435	COG1132	(ABC) transporter
CG476_RS13440	COG3763	UPF0154 protein
CG476_RS13455	COG3639	organic phosphonate transmembrane transporter activity
CG476_RS13460	COG3639	organic phosphonate transmembrane transporter activity
CG476_RS13475	COG0737	Belongs to the 5'-nucleotidase family
CG476_RS13480	COG4224	UPF0291 protein
CG476_RS13485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG476_RS13490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CG476_RS13505	COG1695	Transcriptional regulator
CG476_RS13540	COG3328	transposase activity
CG476_RS13545	COG3328	transposase activity
CG476_RS13550	COG3328	transposase activity
CG476_RS13565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG476_RS13590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG476_RS13610	COG0730	response to heat
CG476_RS13665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG476_RS13735	COG3723	Recombinational DNA repair protein, rece pathway
CG476_RS13780	COG0582	viral genome integration into host DNA
CG476_RS13785	COG0174	glutamine synthetase
CG476_RS13790	COG0789	Transcriptional regulator
CG476_RS13795	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CG476_RS13800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG476_RS13805	COG2860	membrane
CG476_RS13810	COG0464	growth
CG476_RS13825	COG1923	regulation of RNA biosynthetic process
CG476_RS13830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CG476_RS13840	COG1388	LysM domain
CG476_RS13840	COG3584	3D domain protein
CG476_RS13845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG476_RS13845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_RS13845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG476_RS13850	COG1105	Belongs to the carbohydrate kinase PfkB family
CG476_RS13855	COG1349	DNA-binding transcription factor activity
CG476_RS13860	COG2322	membrane
CG476_RS13885	COG2116	formate transmembrane transporter activity
CG476_RS13895	COG1937	Protein conserved in bacteria
CG476_RS13900	COG2819	hydrolase of the alpha beta superfamily
CG476_RS13905	COG1120	ATPase activity
CG476_RS13910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_RS13915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_RS13920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG476_RS13925	COG2706	6-phosphogluconolactonase activity
CG476_RS13930	COG2826	transposase and inactivated derivatives, IS30 family
CG476_RS13935	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG476_RS13945	COG0346	lactoylglutathione lyase activity
CG476_RS13960	COG1113	amino acid transport
CG476_RS13985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CG476_RS13990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CG476_RS14000	COG4550	Control of competence regulator ComK, YlbF/YmcA
CG476_RS14005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG476_RS14010	COG1013	pyruvate-flavodoxin oxidoreductase activity
CG476_RS14015	COG0674	pyruvate-flavodoxin oxidoreductase activity
CG476_RS14015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CG476_RS14025	COG2359	stage V sporulation protein S
CG476_RS14030	COG1692	metallophosphoesterase
CG476_RS14035	COG1418	mRNA catabolic process
CG476_RS14040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CG476_RS14045	COG1546	Belongs to the CinA family
CG476_RS14045	COG1058	Belongs to the CinA family
CG476_RS14050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG476_RS14055	COG1426	Protein conserved in bacteria
CG476_RS14070	COG0300	oxidoreductase activity
CG476_RS14075	COG0612	Peptidase, M16
CG476_RS14080	COG0612	Peptidase, M16
CG476_RS14085	COG1079	Belongs to the binding-protein-dependent transport system permease family
CG476_RS14090	COG4603	Belongs to the binding-protein-dependent transport system permease family
CG476_RS14095	COG3845	ABC transporter
CG476_RS14100	COG1744	ABC transporter substrate-binding protein PnrA-like
CG476_RS14105	COG2188	Transcriptional regulator
CG476_RS14125	COG0740	serine-type endopeptidase activity
CG476_RS14150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG476_RS14165	COG0527	aspartate kinase activity
CG476_RS14170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CG476_RS14175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG476_RS14180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG476_RS14185	COG1873	PFAM PRC-barrel domain
CG476_RS14190	COG0612	Peptidase, M16
CG476_RS14195	COG0726	polysaccharide deacetylase
CG476_RS14200	COG1185	polyribonucleotide nucleotidyltransferase activity
CG476_RS14210	COG0196	riboflavin kinase activity
CG476_RS14215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CG476_RS14220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CG476_RS14225	COG1550	Protein conserved in bacteria
CG476_RS14230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CG476_RS14235	COG1358	cellular component organization or biogenesis
CG476_RS14240	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CG476_RS14245	COG0195	Participates in both transcription termination and antitermination
CG476_RS14250	COG0779	Required for maturation of 30S ribosomal subunits
CG476_RS14260	COG0442	prolyl-tRNA aminoacylation
CG476_RS14265	COG0750	zinc metalloprotease
CG476_RS14275	COG4589	Belongs to the CDS family
CG476_RS14285	COG0233	cytoplasmic translational termination
CG476_RS14290	COG0528	UMP kinase activity
CG476_RS14295	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CG476_RS14300	COG0052	Belongs to the universal ribosomal protein uS2 family
CG476_RS14305	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CG476_RS14310	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CG476_RS14315	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CG476_RS14320	COG4974	Belongs to the 'phage' integrase family
CG476_RS14325	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CG476_RS14330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG476_RS14335	COG0758	DNA mediated transformation
CG476_RS14340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CG476_RS14345	COG0045	succinate-CoA ligase (ADP-forming) activity
CG476_RS14350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG476_RS14365	COG0335	large ribosomal subunit rRNA binding
CG476_RS14370	COG0336	Belongs to the RNA methyltransferase TrmD family
CG476_RS14375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CG476_RS14380	COG1837	Belongs to the UPF0109 family
CG476_RS14385	COG0228	four-way junction DNA binding
CG476_RS14390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CG476_RS14395	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CG476_RS14400	COG0552	protein localization to endoplasmic reticulum
CG476_RS14405	COG1196	nuclear chromosome segregation
CG476_RS14410	COG0571	ribonuclease III activity
CG476_RS14415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG476_RS14420	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS14425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CG476_RS14430	COG0416	fatty acid biosynthetic process
CG476_RS14435	COG2050	protein possibly involved in aromatic compounds catabolism
CG476_RS14435	COG1349	DNA-binding transcription factor activity
CG476_RS14440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CG476_RS14445	COG1461	Dihydroxyacetone kinase
CG476_RS14450	COG1302	Protein conserved in bacteria
CG476_RS14455	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CG476_RS14465	COG1564	THIamine pyrophosphokinase
CG476_RS14470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CG476_RS14475	COG1162	GTPase activity
CG476_RS14480	COG0515	serine threonine protein kinase
CG476_RS14480	COG2815	serine threonine protein kinase
CG476_RS14485	COG0631	protein serine/threonine phosphatase activity
CG476_RS14490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CG476_RS14495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CG476_RS14495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG476_RS14500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG476_RS14505	COG0242	peptide deformylase activity
CG476_RS14510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CG476_RS14515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG476_RS14520	COG1758	RNA polymerase activity
CG476_RS14535	COG1561	YicC-like family, N-terminal region
CG476_RS14540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG476_RS14565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CG476_RS14570	COG0284	orotidine-5'-phosphate decarboxylase activity
CG476_RS14575	COG0167	dihydroorotate dehydrogenase activity
CG476_RS14580	COG0543	2 iron, 2 sulfur cluster binding
CG476_RS14585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CG476_RS14595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CG476_RS14600	COG0540	Belongs to the ATCase OTCase family
CG476_RS14610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CG476_RS14620	COG0564	pseudouridine synthase activity
CG476_RS14625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CG476_RS14635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CG476_RS14640	COG3599	regulation of cell shape
CG476_RS14645	COG2302	S4 RNA-binding domain
CG476_RS14650	COG0762	integral membrane protein
CG476_RS14655	COG1799	cell septum assembly
CG476_RS14660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CG476_RS14670	COG1873	PFAM PRC-barrel domain
CG476_RS14675	COG1191	sigma factor activity
CG476_RS14680	COG1191	sigma factor activity
CG476_RS14690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CG476_RS14695	COG0849	cell division
CG476_RS14700	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CG476_RS14710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG476_RS14715	COG0772	Belongs to the SEDS family
CG476_RS14720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CG476_RS14725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG476_RS14730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CG476_RS14735	COG0768	penicillin binding
CG476_RS14740	COG0768	penicillin binding
CG476_RS14745	COG4839	cell division protein FtsL
CG476_RS14750	COG0275	rRNA processing
CG476_RS14755	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CG476_RS14760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CG476_RS14765	COG0454	-acetyltransferase
CG476_RS14775	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CG476_RS14780	COG1399	metal-binding, possibly nucleic acid-binding protein
CG476_RS14890	COG4626	Terminase
CG476_RS14890	COG1802	Transcriptional regulator
CG476_RS14980	COG0756	dUTP diphosphatase activity
CG476_RS15010	COG3723	Recombinational DNA repair protein, rece pathway
CG476_RS15020	COG5377	YqaJ viral recombinase family
CG476_RS15060	COG0582	viral genome integration into host DNA
CG476_RS15065	COG1323	Belongs to the UPF0348 family
CG476_RS15070	COG3480	Lon protease (S16) C-terminal proteolytic domain
CG476_RS15075	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG476_RS15080	COG3314	Sporulation integral membrane protein YlbJ
CG476_RS15085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CG476_RS15090	COG0742	ribosomal rna small subunit methyltransferase
CG476_RS15100	COG4471	UPF0298 protein
CG476_RS15105	COG3679	Belongs to the UPF0342 family
CG476_RS15110	COG0406	alpha-ribazole phosphatase activity
CG476_RS15125	COG2340	Cysteine-rich secretory protein family
CG476_RS15135	COG3336	cytochrome c oxidase
CG476_RS15160	COG0109	protoheme IX farnesyltransferase activity
CG476_RS15165	COG1612	heme a metabolic process
CG476_RS15170	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CG476_RS15180	COG0772	Belongs to the SEDS family
CG476_RS15185	COG4838	Belongs to the UPF0358 family
CG476_RS15190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CG476_RS15195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CG476_RS15205	COG4896	Protein conserved in bacteria
CG476_RS15220	COG1217	gtp-binding protein TYPA
CG476_RS15230	COG0483	inositol monophosphate 1-phosphatase activity
CG476_RS15240	COG4493	Belongs to the UPF0637 family
CG476_RS15245	COG4476	Belongs to the UPF0223 family
CG476_RS15250	COG1982	Orn Lys Arg decarboxylase major
CG476_RS15290	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG476_RS15300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG476_RS15315	COG0561	phosphatase activity
CG476_RS15325	COG5503	Protein of unknown function (DUF1447)
CG476_RS15330	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG476_RS15335	COG0569	domain protein
CG476_RS15345	COG1473	amidohydrolase
CG476_RS15350	COG2171	N-acyltransferase activity
CG476_RS15355	COG0583	DNA-binding transcription factor activity
CG476_RS15360	COG0517	IMP dehydrogenase activity
CG476_RS15370	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CG476_RS15390	COG4703	Protein of unknown function (DUF1797)
CG476_RS15405	COG2200	EAL domain
CG476_RS15410	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS15415	COG1408	metallophosphoesterase
CG476_RS15425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CG476_RS15430	COG0248	Ppx GppA phosphatase
CG476_RS15465	COG2814	Major facilitator Superfamily
CG476_RS15470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CG476_RS15480	COG3209	COG3209 Rhs family protein
CG476_RS15490	COG2205	protein histidine kinase activity
CG476_RS15500	COG0436	Aminotransferase
CG476_RS15505	COG1609	Transcriptional regulator
CG476_RS15510	COG3833	ABC-type maltose transport systems, permease component
CG476_RS15515	COG1175	transmembrane transport
CG476_RS15520	COG2182	Extracellular solute-binding protein
CG476_RS15540	COG0366	Alpha amylase catalytic
CG476_RS15545	COG3842	ATPase activity
CG476_RS15575	COG0183	Belongs to the thiolase family
CG476_RS15605	COG1695	Transcriptional regulator
CG476_RS15610	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS15620	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CG476_RS15625	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CG476_RS15630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CG476_RS15635	COG0436	Aminotransferase
CG476_RS15640	COG1850	ribulose-bisphosphate carboxylase activity
CG476_RS15645	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CG476_RS15650	COG0235	Class ii aldolase
CG476_RS15655	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CG476_RS15670	COG2084	Dehydrogenase
CG476_RS15680	COG2199	diguanylate cyclase activity
CG476_RS15685	COG0778	Nitroreductase
CG476_RS15710	COG2190	(PTS) system
CG476_RS15710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG476_RS15710	COG1263	PTS System
CG476_RS15715	COG3711	transcriptional antiterminator
CG476_RS15725	COG2188	Transcriptional regulator
CG476_RS15730	COG0363	glucosamine-6-phosphate deaminase activity
CG476_RS15745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CG476_RS15750	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CG476_RS15760	COG1547	Domain of unknown function (DUF309)
CG476_RS15770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CG476_RS15775	COG4086	secreted protein
CG476_RS15780	COG0561	phosphatase activity
CG476_RS15785	COG0697	spore germination
CG476_RS15800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG476_RS15825	COG0733	neurotransmitter:sodium symporter activity
CG476_RS15835	COG2172	sigma factor antagonist activity
CG476_RS15845	COG1686	Belongs to the peptidase S11 family
CG476_RS15855	COG1725	Transcriptional regulator
CG476_RS15860	COG1131	(ABC) transporter
CG476_RS15885	COG1846	Transcriptional regulator
CG476_RS15900	COG0598	Magnesium transport protein CorA
CG476_RS15930	COG4974	Belongs to the 'phage' integrase family
CG476_RS15940	COG0735	belongs to the Fur family
CG476_RS15945	COG1300	Membrane
CG476_RS15965	COG0667	Aldo Keto reductase
CG476_RS15970	COG0656	L-ascorbic acid biosynthetic process
CG476_RS15975	COG0456	acetyltransferase
CG476_RS15975	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CG476_RS15985	COG1525	nuclease
CG476_RS15985	COG4085	toxin activity
CG476_RS15985	COG0737	Belongs to the 5'-nucleotidase family
CG476_RS15995	COG0596	Alpha beta hydrolase
CG476_RS16000	COG2056	Na+-H+ antiporter family
CG476_RS16005	COG1609	Transcriptional regulator
CG476_RS16010	COG0456	acetyltransferase
CG476_RS16015	COG1073	alpha beta
CG476_RS16030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG476_RS16030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG476_RS16035	COG0307	riboflavin synthase, alpha
CG476_RS16040	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG476_RS16040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG476_RS16055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CG476_RS16060	COG4106	trans-aconitate 2-methyltransferase activity
CG476_RS16065	COG0596	Alpha beta hydrolase
CG476_RS16070	COG0156	8-amino-7-oxononanoate synthase activity
CG476_RS16080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG476_RS16090	COG1757	Na H antiporter
CG476_RS16095	COG0737	Belongs to the 5'-nucleotidase family
CG476_RS16120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CG476_RS16130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CG476_RS16140	COG0300	oxidoreductase activity
CG476_RS16145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG476_RS16150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG476_RS16155	COG1760	l-serine dehydratase
CG476_RS16160	COG1760	l-serine dehydratase
CG476_RS16170	COG1234	tRNA 3'-trailer cleavage
CG476_RS16190	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG476_RS16195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG476_RS16210	COG1376	ErfK ybiS ycfS ynhG family protein
CG476_RS16215	COG4129	membrane
CG476_RS16220	COG1126	abc transporter atp-binding protein
CG476_RS16225	COG0765	amino acid transport
CG476_RS16230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG476_RS16245	COG2816	NAD+ diphosphatase activity
CG476_RS16250	COG0772	Belongs to the SEDS family
CG476_RS16260	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG476_RS16265	COG0022	dehydrogenase e1 component
CG476_RS16270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG476_RS16275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG476_RS16280	COG3426	butyrate kinase activity
CG476_RS16290	COG0280	phosphate acetyltransferase
CG476_RS16300	COG3290	protein histidine kinase activity
CG476_RS16300	COG3829	transcription factor binding
CG476_RS16310	COG0584	glycerophosphoryl diester phosphodiesterase
CG476_RS16315	COG3093	addiction module antidote protein HigA
CG476_RS16320	COG0745	RESPONSE REGULATOR receiver
CG476_RS16330	COG0750	zinc metalloprotease
CG476_RS16335	COG0497	DNA recombination
CG476_RS16345	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CG476_RS16350	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CG476_RS16360	COG1722	exodeoxyribonuclease VII activity
CG476_RS16365	COG1570	exodeoxyribonuclease VII activity
CG476_RS16370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CG476_RS16375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG476_RS16380	COG1302	Protein conserved in bacteria
CG476_RS16385	COG0439	Biotin carboxylase
CG476_RS16390	COG0511	ligase activity, forming carbon-carbon bonds
CG476_RS16435	COG3854	ATPases associated with a variety of cellular activities
CG476_RS16455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CG476_RS16460	COG0006	proline dipeptidase activity
CG476_RS16465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CG476_RS16475	COG3872	metal-dependent enzyme
CG476_RS16485	COG1321	iron dependent repressor
CG476_RS16500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG476_RS16510	COG1609	Transcriptional regulator
CG476_RS16520	COG2076	Multidrug Resistance protein
CG476_RS16525	COG2076	Multidrug Resistance protein
CG476_RS16545	COG1131	(ABC) transporter
CG476_RS16550	COG1725	Transcriptional regulator
CG476_RS16565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG476_RS16570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG476_RS16575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CG476_RS16580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG476_RS16610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CG476_RS16635	COG1459	type II secretion system
CG476_RS16660	COG4824	toxin secretion phage lysis holin
CG476_RS16745	COG3728	DNA packaging
CG476_RS16755	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG476_RS16820	COG1484	DNA-dependent DNA replication
CG476_RS16835	COG3723	Recombinational DNA repair protein, rece pathway
CG476_RS16840	COG5377	YqaJ viral recombinase family
CG476_RS16865	COG1396	sequence-specific DNA binding
CG476_RS16880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CG476_RS16915	COG1078	dGTPase activity
CG476_RS16935	COG1410	methionine synthase
CG476_RS16935	COG0646	methionine synthase
CG476_RS16940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CG476_RS16940	COG0646	methionine synthase
CG476_RS16945	COG0626	cystathionine gamma-synthase activity
CG476_RS16950	COG0626	cystathionine gamma-synthase activity
CG476_RS16970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG476_RS16980	COG1940	carbohydrate kinase activity
CG476_RS16985	COG4483	Protein conserved in bacteria
CG476_RS16990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CG476_RS16995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG476_RS17005	COG0704	Plays a role in the regulation of phosphate uptake
CG476_RS17015	COG0581	inorganic phosphate transmembrane transporter activity
CG476_RS17020	COG0573	inorganic phosphate transmembrane transporter activity
CG476_RS17025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG476_RS17030	COG0768	penicillin binding
CG476_RS17035	COG0477	Major facilitator Superfamily
CG476_RS17040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG476_RS17060	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CG476_RS17065	COG0735	belongs to the Fur family
CG476_RS17070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG476_RS17075	COG1121	(ABC) transporter
CG476_RS17080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_RS17090	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CG476_RS17105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CG476_RS17110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CG476_RS17115	COG2384	SAM-dependent methyltransferase
CG476_RS17125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CG476_RS17130	COG0358	DNA primase activity
CG476_RS17135	COG1671	Belongs to the UPF0178 family
CG476_RS17140	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CG476_RS17145	COG0517	IMP dehydrogenase activity
CG476_RS17150	COG1381	Involved in DNA repair and RecF pathway recombination
CG476_RS17160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CG476_RS17170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CG476_RS17175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CG476_RS17180	COG1480	7TM receptor with intracellular HD hydrolase
CG476_RS17185	COG1702	phosphate starvation-inducible protein PhoH
CG476_RS17200	COG1610	YqeY-like protein
CG476_RS17205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CG476_RS17210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG476_RS17215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CG476_RS17220	COG2264	protein methyltransferase activity
CG476_RS17225	COG0484	heat shock protein binding
CG476_RS17230	COG0443	Heat shock 70 kDa protein
CG476_RS17235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CG476_RS17240	COG1420	regulation of RNA biosynthetic process
CG476_RS17245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG476_RS17250	COG1733	regulation of RNA biosynthetic process
CG476_RS17255	COG0693	protein deglycase activity
CG476_RS17260	COG0481	GTPase activity
CG476_RS17270	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CG476_RS17275	COG0268	Binds directly to 16S ribosomal RNA
CG476_RS17280	COG1466	dna polymerase III delta subunit
CG476_RS17290	COG2333	competence protein COMEC
CG476_RS17290	COG0658	competence protein
CG476_RS17295	COG2131	deaminase
CG476_RS17300	COG1555	photosystem II stabilization
CG476_RS17300	COG1596	polysaccharide export
CG476_RS17305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG476_RS17310	COG2226	methyltransferase
CG476_RS17315	COG0799	negative regulation of ribosome biogenesis
CG476_RS17320	COG1713	HD superfamily hydrolase involved in NAD metabolism
CG476_RS17325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CG476_RS17330	COG1534	Rna-binding protein
CG476_RS17335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CG476_RS17340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CG476_RS17345	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CG476_RS17355	COG0688	phosphatidylethanolamine metabolic process
CG476_RS17370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG476_RS17375	COG2357	RelA SpoT domain protein
CG476_RS17380	COG1785	Belongs to the alkaline phosphatase family
CG476_RS17385	COG0456	acetyltransferase
CG476_RS17390	COG2267	carboxylic ester hydrolase activity
CG476_RS17415	COG3186	Phenylalanine-4-hydroxylase
CG476_RS17420	COG2154	pterin-4-alpha-carbinolamine dehydratase
CG476_RS17425	COG2514	catechol 2,3-dioxygenase activity
CG476_RS17430	COG2259	Doxx family
CG476_RS17445	COG1609	Transcriptional regulator
CG476_RS17460	COG0626	cystathionine gamma-synthase activity
CG476_RS17465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG476_RS17470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CG476_RS17475	COG2226	methyltransferase
CG476_RS17490	COG0768	penicillin binding
CG476_RS17500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CG476_RS17505	COG0572	uridine kinase
CG476_RS17510	COG0826	peptidase U32
CG476_RS17515	COG0826	peptidase U32
CG476_RS17520	COG4122	O-methyltransferase activity
CG476_RS17525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CG476_RS17535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CG476_RS17540	COG4472	Bacterial protein of unknown function (DUF965)
CG476_RS17545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG476_RS17550	COG0628	permease
CG476_RS17570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CG476_RS17580	COG0482	sulfurtransferase activity
CG476_RS17585	COG1104	cysteine desulfurase activity
CG476_RS17590	COG1959	2 iron, 2 sulfur cluster binding
CG476_RS17595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CG476_RS17615	COG2207	Transcriptional regulator
CG476_RS17625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CG476_RS17630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CG476_RS17635	COG0124	histidyl-tRNA synthetase
CG476_RS17655	COG1490	D-aminoacyl-tRNA deacylase activity
CG476_RS17660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG476_RS17665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG476_RS17670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CG476_RS17670	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CG476_RS17675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG476_RS17680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG476_RS17680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG476_RS17690	COG2244	polysaccharide biosynthetic process
CG476_RS17715	COG1862	Preprotein translocase
CG476_RS17720	COG0343	queuine tRNA-ribosyltransferase activity
CG476_RS17725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CG476_RS17735	COG2255	four-way junction helicase activity
CG476_RS17740	COG0632	four-way junction helicase activity
CG476_RS17745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CG476_RS17765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CG476_RS17770	COG0157	Belongs to the NadC ModD family
CG476_RS17775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CG476_RS17780	COG1104	cysteine desulfurase activity
CG476_RS17785	COG1827	regulation of RNA biosynthetic process
CG476_RS17790	COG2258	MOSC domain
CG476_RS17795	COG0077	Prephenate dehydratase
CG476_RS17800	COG0577	efflux transmembrane transporter activity
CG476_RS17805	COG0577	efflux transmembrane transporter activity
CG476_RS17810	COG1136	(ABC) transporter
CG476_RS17815	COG5002	protein histidine kinase activity
CG476_RS17820	COG0745	RESPONSE REGULATOR receiver
CG476_RS17830	COG3290	protein histidine kinase activity
CG476_RS17835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CG476_RS17840	COG2868	ribosomal protein
CG476_RS17845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CG476_RS17850	COG1530	ribonuclease E activity
CG476_RS17855	COG1994	Peptidase M50
CG476_RS17860	COG0739	heme binding
CG476_RS17865	COG2894	cell division
CG476_RS17870	COG0850	regulation of cytokinetic process
CG476_RS17880	COG1792	Involved in formation and maintenance of cell shape
CG476_RS17885	COG1077	Cell shape determining protein MreB Mrl
CG476_RS17905	COG0424	maF-like protein
CG476_RS17915	COG0285	dihydrofolate synthase activity
CG476_RS17940	COG1388	LysM domain
CG476_RS17940	COG1388	LysM domain
CG476_RS17945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG476_RS17950	COG0113	porphobilinogen synthase activity
CG476_RS17955	COG1587	Uroporphyrinogen-III synthase
CG476_RS17960	COG0181	hydroxymethylbilane synthase activity
CG476_RS17965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG476_RS17970	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CG476_RS17975	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CG476_RS17985	COG1067	ATP-dependent peptidase activity
CG476_RS17985	COG0470	DNA polymerase III
CG476_RS17990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CG476_RS17995	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG476_RS18020	COG3321	synthase
CG476_RS18020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG476_RS18020	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS18020	COG4221	oxidoreductase activity
CG476_RS18035	COG2409	Drug exporters of the RND superfamily
CG476_RS18035	COG1033	growth of symbiont in host cell
CG476_RS18045	COG1309	transcriptional regulator
CG476_RS18105	COG0622	Phosphoesterase
CG476_RS18115	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CG476_RS18120	COG5401	PFAM Sporulation and spore germination
CG476_RS18130	COG2197	response regulator
CG476_RS18140	COG1959	2 iron, 2 sulfur cluster binding
CG476_RS18145	COG1668	transmembrane transport
CG476_RS18150	COG4152	abc transporter atp-binding protein
CG476_RS18155	COG1360	Flagellar Motor Protein
CG476_RS18160	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG476_RS18170	COG1876	peptidase activity
CG476_RS18180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CG476_RS18185	COG1053	succinate dehydrogenase
CG476_RS18190	COG2009	succinate dehydrogenase
CG476_RS18195	COG1719	4-vinyl reductase, 4VR
CG476_RS18210	COG3118	belongs to the thioredoxin family
CG476_RS18215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CG476_RS18220	COG2086	electron transfer activity
CG476_RS18225	COG1024	Enoyl-CoA hydratase
CG476_RS18230	COG1309	transcriptional regulator
CG476_RS18235	COG0318	PFAM AMP-dependent synthetase and ligase
CG476_RS18245	COG2318	DinB family
CG476_RS18260	COG1131	(ABC) transporter
CG476_RS18265	COG2205	protein histidine kinase activity
CG476_RS18270	COG0745	RESPONSE REGULATOR receiver
CG476_RS18280	COG4895	conserved protein (DUF2196)
CG476_RS18285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CG476_RS18290	COG1114	Component of the transport system for branched-chain amino acids
CG476_RS18295	COG1187	pseudouridine synthase activity
CG476_RS18305	COG1193	negative regulation of DNA recombination
CG476_RS18310	COG1796	DNA polymerase
CG476_RS18310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CG476_RS18315	COG1286	toxin biosynthetic process
CG476_RS18320	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CG476_RS18325	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG476_RS18345	COG0017	Asparaginyl-tRNA synthetase
CG476_RS18355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CG476_RS18360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG476_RS18370	COG1418	mRNA catabolic process
CG476_RS18385	COG2814	Major facilitator Superfamily
CG476_RS18390	COG1566	PFAM secretion protein HlyD family protein
CG476_RS18395	COG1309	transcriptional regulator
CG476_RS18400	COG1363	Peptidase, m42
CG476_RS18410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CG476_RS18415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CG476_RS18425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG476_RS18435	COG1484	DNA-dependent DNA replication
CG476_RS18440	COG3611	Membrane attachment protein
CG476_RS18445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CG476_RS18450	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CG476_RS18455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG476_RS18465	COG1971	Probably functions as a manganese efflux pump
CG476_RS18475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG476_RS18475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG476_RS18480	COG5002	protein histidine kinase activity
CG476_RS18485	COG0745	RESPONSE REGULATOR receiver
CG476_RS18495	COG0039	L-malate dehydrogenase activity
CG476_RS18500	COG0538	isocitrate dehydrogenase activity
CG476_RS18505	COG0372	Belongs to the citrate synthase family
CG476_RS18515	COG2707	UPF0756 membrane protein
CG476_RS18525	COG0628	permease
CG476_RS18530	COG3030	protein affecting phage T7 exclusion by the F plasmid
CG476_RS18540	COG0205	6-phosphofructokinase activity
CG476_RS18545	COG0825	malonyl-CoA metabolic process
CG476_RS18550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CG476_RS18555	COG1725	Transcriptional regulator
CG476_RS18560	COG0281	malic enzyme
CG476_RS18565	COG0587	DNA-directed DNA polymerase activity
CG476_RS18580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CG476_RS18595	COG4109	DRTGG domain
CG476_RS18600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CG476_RS18605	COG0006	proline dipeptidase activity
CG476_RS18630	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS18635	COG0589	response to stress
CG476_RS18660	COG0165	Argininosuccinate lyase
CG476_RS18665	COG0137	argininosuccinate synthase activity
CG476_RS18675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_RS18685	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG476_RS18690	COG0827	DNA restriction-modification system
CG476_RS18695	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CG476_RS18700	COG3874	Sporulation protein YtfJ
CG476_RS18715	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CG476_RS18720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG476_RS18730	COG0301	tRNA thio-modification
CG476_RS18735	COG1104	cysteine desulfurase activity
CG476_RS18740	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CG476_RS18745	COG0583	DNA-binding transcription factor activity
CG476_RS18750	COG0697	spore germination
CG476_RS18755	COG1309	transcriptional regulator
CG476_RS18760	COG1956	GAF domain-containing protein
CG476_RS18765	COG0626	cystathionine gamma-synthase activity
CG476_RS18775	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CG476_RS18810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG476_RS18815	COG0454	-acetyltransferase
CG476_RS18820	COG0517	IMP dehydrogenase activity
CG476_RS18825	COG0123	including yeast histone deacetylase and acetoin utilization protein
CG476_RS18830	COG1970	mechanosensitive ion channel activity
CG476_RS18840	COG1609	Transcriptional regulator
CG476_RS18850	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG476_RS18850	COG1605	Chorismate mutase
CG476_RS18855	COG3118	belongs to the thioredoxin family
CG476_RS18865	COG2309	aminopeptidase activity
CG476_RS18880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CG476_RS18890	COG1674	ftsk spoiiie
CG476_RS18900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG476_RS18905	COG4848	Belongs to the UPF0354 family
CG476_RS18910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG476_RS18915	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CG476_RS18935	COG1363	Peptidase, m42
CG476_RS18945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG476_RS18950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CG476_RS18960	COG0510	thiamine kinase activity
CG476_RS18965	COG1523	belongs to the glycosyl hydrolase 13 family
CG476_RS18975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG476_RS18980	COG1349	DNA-binding transcription factor activity
CG476_RS18985	COG1187	pseudouridine synthase activity
CG476_RS18990	COG2244	polysaccharide biosynthetic process
CG476_RS18995	COG2081	HI0933 family
CG476_RS19000	COG2814	Major facilitator Superfamily
CG476_RS19010	COG3832	glyoxalase III activity
CG476_RS19030	COG1329	Transcriptional regulator
CG476_RS19040	COG2223	nitrite transmembrane transporter activity
CG476_RS19050	COG0314	molybdopterin synthase activity
CG476_RS19055	COG1763	Mo-molybdopterin cofactor biosynthetic process
CG476_RS19060	COG0303	'Molybdopterin
CG476_RS19065	COG0315	cyclic pyranopterin monophosphate synthase activity
CG476_RS19070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG476_RS19075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CG476_RS19080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG476_RS19085	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CG476_RS19090	COG1140	nitrate reductase beta subunit
CG476_RS19095	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CG476_RS19100	COG2181	nitrate reductase activity
CG476_RS19115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG476_RS19125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CG476_RS19165	COG0495	leucyl-tRNA aminoacylation
CG476_RS19170	COG2814	Major facilitator Superfamily
CG476_RS19180	COG1136	(ABC) transporter
CG476_RS19185	COG0346	lactoylglutathione lyase activity
CG476_RS19200	COG1242	4 iron, 4 sulfur cluster binding
CG476_RS19205	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CG476_RS19210	COG1121	(ABC) transporter
CG476_RS19220	COG1794	racemase activity, acting on amino acids and derivatives
CG476_RS19230	COG2378	regulation of single-species biofilm formation
CG476_RS19240	COG2267	carboxylic ester hydrolase activity
CG476_RS19255	COG0746	molybdenum cofactor guanylyltransferase activity
CG476_RS19280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CG476_RS19290	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CG476_RS19340	COG0800	Aldolase
CG476_RS19345	COG2610	gluconate transmembrane transporter activity
CG476_RS19350	COG1312	Catalyzes the dehydration of D-mannonate
CG476_RS19355	COG0246	Mannitol dehydrogenase
CG476_RS19360	COG1414	Transcriptional regulator
CG476_RS19365	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG476_RS19365	COG3409	Peptidoglycan-binding domain 1 protein
CG476_RS19375	COG1368	sulfuric ester hydrolase activity
CG476_RS19390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG476_RS19395	COG1116	anion transmembrane transporter activity
CG476_RS19400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG476_RS19415	COG0494	nUDIX hydrolase
CG476_RS19425	COG1854	S-ribosylhomocysteine lyase activity
CG476_RS19430	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CG476_RS19435	COG0288	reversible hydration of carbon dioxide
CG476_RS19440	COG1271	oxidase subunit
CG476_RS19445	COG1294	oxidase, subunit
CG476_RS19475	COG1842	Phage shock protein A
CG476_RS19515	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CG476_RS19520	COG1597	lipid kinase activity
CG476_RS19525	COG1136	(ABC) transporter
CG476_RS19535	COG0745	RESPONSE REGULATOR receiver
CG476_RS19540	COG2205	protein histidine kinase activity
CG476_RS19545	COG0577	efflux transmembrane transporter activity
CG476_RS19550	COG1136	(ABC) transporter
CG476_RS19555	COG0577	efflux transmembrane transporter activity
CG476_RS19570	COG4948	Mandelate Racemase Muconate Lactonizing
CG476_RS19575	COG0318	PFAM AMP-dependent synthetase and ligase
CG476_RS19580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CG476_RS19585	COG0596	Alpha beta hydrolase
CG476_RS19590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CG476_RS19595	COG1169	isochorismate synthase
CG476_RS19600	COG1575	Belongs to the MenA family. Type 1 subfamily
CG476_RS19605	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CG476_RS19625	COG0058	SHG alpha-glucan phosphorylase activity
CG476_RS19630	COG0297	glycogen (starch) synthase activity
CG476_RS19635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG476_RS19640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG476_RS19645	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CG476_RS19750	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG476_RS19785	COG1285	pathogenesis
CG476_RS19790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG476_RS19800	COG0166	Belongs to the GPI family
CG476_RS19810	COG2155	Conserved Protein
CG476_RS19815	COG1098	S1 RNA binding domain
CG476_RS19820	COG0436	Aminotransferase
CG476_RS19825	COG1522	sequence-specific DNA binding
CG476_RS19830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG476_RS19835	COG2267	carboxylic ester hydrolase activity
CG476_RS19845	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CG476_RS19850	COG2032	superoxide dismutase activity
CG476_RS19860	COG5018	Exonuclease
CG476_RS19865	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG476_RS19890	COG2050	protein possibly involved in aromatic compounds catabolism
CG476_RS19900	COG1268	BioY protein
CG476_RS19905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG476_RS19910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG476_RS19920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CG476_RS19930	COG3584	3D domain protein
CG476_RS19950	COG1252	NADH dehydrogenase
CG476_RS19955	COG0492	ferredoxin-NADP+ reductase activity
CG476_RS19970	COG1683	Conserved Protein
CG476_RS20005	COG1131	(ABC) transporter
CG476_RS20030	COG0316	Belongs to the HesB IscA family
CG476_RS20035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CG476_RS20040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG476_RS20050	COG1252	NADH dehydrogenase
CG476_RS20055	COG2824	Alkylphosphonate utilization operon protein PhnA
CG476_RS20065	COG3655	Transcriptional regulator
CG476_RS20080	COG4837	Protein of unknown function (DUF1462)
CG476_RS20085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CG476_RS20090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG476_RS20095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CG476_RS20100	COG0647	UMP catabolic process
CG476_RS20110	COG2445	Protein of unknown function DUF86
CG476_RS20115	COG1494	fructose-1,6-bisphosphatase
CG476_RS20125	COG4470	Protein conserved in bacteria
CG476_RS20135	COG0789	Transcriptional regulator
CG476_RS20140	COG4377	Putative membrane peptidase family (DUF2324)
CG476_RS20155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CG476_RS20160	COG0739	heme binding
CG476_RS20170	COG3377	Domain of unknown function (DUF1805)
CG476_RS20175	COG0737	Belongs to the 5'-nucleotidase family
CG476_RS20195	COG0719	Fe-S assembly protein
CG476_RS20200	COG0822	iron-sulfur transferase activity
CG476_RS20205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CG476_RS20210	COG0719	Fe-S assembly protein
CG476_RS20215	COG0396	ATPase activity
CG476_RS20220	COG1464	Belongs to the NlpA lipoprotein family
CG476_RS20225	COG2011	ABC-type metal ion transport system permease component
CG476_RS20245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG476_RS20250	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CG476_RS20255	COG0509	glycine decarboxylation via glycine cleavage system
CG476_RS20260	COG1393	Belongs to the ArsC family
CG476_RS20300	COG1960	acyl-CoA dehydrogenase activity
CG476_RS20305	COG0183	Belongs to the thiolase family
CG476_RS20310	COG1024	Enoyl-CoA hydratase
CG476_RS20310	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG476_RS20320	COG1686	Belongs to the peptidase S11 family
CG476_RS20345	COG0011	TIGRFAM Protein of
CG476_RS20350	COG0840	transmembrane signaling receptor activity
CG476_RS20365	COG0531	amino acid
CG476_RS20370	COG0706	membrane insertase activity
CG476_RS20380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_RS20390	COG0586	Pfam SNARE associated Golgi protein
CG476_RS20400	COG1376	ErfK ybiS ycfS ynhG family protein
CG476_RS20405	COG0745	RESPONSE REGULATOR receiver
CG476_RS20410	COG5002	protein histidine kinase activity
CG476_RS20415	COG0840	transmembrane signaling receptor activity
CG476_RS20420	COG0840	transmembrane signaling receptor activity
CG476_RS20425	COG2151	metal-sulfur cluster biosynthetic enzyme
CG476_RS20430	COG3227	Zinc metalloprotease (Elastase)
CG476_RS20435	COG1741	Belongs to the pirin family
CG476_RS20450	COG0783	Belongs to the Dps family
CG476_RS20455	COG1611	Belongs to the LOG family
CG476_RS20480	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG476_RS20485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG476_RS20490	COG1121	(ABC) transporter
CG476_RS20515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG476_RS20520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG476_RS20525	COG1115	amino acid carrier protein
CG476_RS20530	COG2910	NAD(P)H-binding
CG476_RS20545	COG1252	NADH dehydrogenase
CG476_RS20560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG476_RS20575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG476_RS20580	COG4977	sequence-specific DNA binding
CG476_RS20580	COG1917	Cupin 2, conserved barrel domain protein
CG476_RS20590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CG476_RS20610	COG0697	spore germination
CG476_RS20625	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CG476_RS20630	COG0557	exoribonuclease II activity
CG476_RS20635	COG1647	Serine aminopeptidase, S33
CG476_RS20640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CG476_RS20645	COG1346	cytolysis
CG476_RS20655	COG0148	phosphopyruvate hydratase activity
CG476_RS20660	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CG476_RS20665	COG0149	triose-phosphate isomerase activity
CG476_RS20670	COG0126	phosphoglycerate kinase activity
CG476_RS20675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG476_RS20690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CG476_RS20740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG476_RS20755	COG2323	membrane
CG476_RS20770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_RS20775	COG1481	regulation of sporulation
CG476_RS20780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CG476_RS20785	COG1660	Displays ATPase and GTPase activities
CG476_RS20790	COG1051	belongs to the nudix hydrolase family
CG476_RS20800	COG0492	ferredoxin-NADP+ reductase activity
CG476_RS20805	COG0457	Tetratricopeptide repeat
CG476_RS20810	COG0110	maltose O-acetyltransferase activity
CG476_RS20820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CG476_RS20825	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CG476_RS20830	COG1950	PFAM Membrane protein of
CG476_RS20840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CG476_RS20855	COG0789	Transcriptional regulator
CG476_RS20875	COG0583	DNA-binding transcription factor activity
CG476_RS20890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG476_RS20895	COG3409	Peptidoglycan-binding domain 1 protein
CG476_RS20895	COG0793	Belongs to the peptidase S41A family
CG476_RS20900	COG2177	Part of the ABC transporter FtsEX involved in
CG476_RS20905	COG2884	Cell division ATP-binding protein ftsE
CG476_RS20930	COG1278	Cold shock
CG476_RS20935	COG1040	competence protein
CG476_RS20940	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CG476_RS20945	COG0791	NLP P60 protein
CG476_RS20945	COG1388	LysM domain
CG476_RS20950	COG1733	regulation of RNA biosynthetic process
CG476_RS20955	COG1307	EDD domain protein, DegV family
CG476_RS20960	COG1739	Uncharacterized protein family UPF0029
CG476_RS20965	COG1316	TRANSCRIPTIONal
CG476_RS20975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CG476_RS20985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG476_RS20995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CG476_RS20995	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CG476_RS21010	COG1486	melibiose metabolic process
CG476_RS21015	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG476_RS21030	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG476_RS21035	COG1301	dicarboxylic acid transport
CG476_RS21040	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CG476_RS21045	COG1271	oxidase subunit
CG476_RS21050	COG1294	oxidase, subunit
CG476_RS21055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CG476_RS21060	COG1620	l-lactate permease
CG476_RS21065	COG2389	metal-binding protein
CG476_RS21075	COG1368	sulfuric ester hydrolase activity
CG476_RS21085	COG0791	NLP P60 protein
CG476_RS21085	COG1388	LysM domain
CG476_RS21090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG476_RS21100	COG1215	transferase activity, transferring glycosyl groups
CG476_RS21110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG476_RS21115	COG3584	3D domain protein
CG476_RS21115	COG1388	LysM domain
CG476_RS21130	COG4715	Zinc finger, swim domain protein
CG476_RS21135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG476_RS21175	COG0577	efflux transmembrane transporter activity
CG476_RS21180	COG1136	(ABC) transporter
CG476_RS21215	COG5002	protein histidine kinase activity
CG476_RS21215	COG3850	Histidine kinase
CG476_RS21220	COG0745	RESPONSE REGULATOR receiver
CG476_RS21230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG476_RS21240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG476_RS21240	COG1215	transferase activity, transferring glycosyl groups
CG476_RS21245	COG1134	teichoic acid transport
CG476_RS21250	COG1682	transport, permease protein
CG476_RS21255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG476_RS21260	COG0463	Glycosyl transferase, family 2
CG476_RS21260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG476_RS21265	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG476_RS21270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CG476_RS21285	COG1609	Transcriptional regulator
CG476_RS21295	COG0739	heme binding
CG476_RS21315	COG2385	sporulation resulting in formation of a cellular spore
CG476_RS21330	COG4836	Membrane
CG476_RS21335	COG1007	ATP synthesis coupled electron transport
CG476_RS21340	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG476_RS21345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG476_RS21350	COG0713	ATP synthesis coupled electron transport
CG476_RS21355	COG0839	Belongs to the complex I subunit 6 family
CG476_RS21365	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CG476_RS21370	COG0649	NAD binding
CG476_RS21375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG476_RS21380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG476_RS21385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG476_RS21390	COG3300	MHYT domain
CG476_RS21390	COG5001	Diguanylate cyclase
CG476_RS21395	COG5001	Diguanylate cyclase
CG476_RS21395	COG3300	MHYT domain
CG476_RS21410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CG476_RS21415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CG476_RS21425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CG476_RS21430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CG476_RS21435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG476_RS21440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CG476_RS21445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG476_RS21470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CG476_RS21475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CG476_RS21485	COG0698	ribose 5-phosphate isomerase
CG476_RS21510	COG2259	Doxx family
CG476_RS21515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CG476_RS21530	COG0009	L-threonylcarbamoyladenylate synthase
CG476_RS21545	COG2890	protein-(glutamine-N5) methyltransferase activity
CG476_RS21550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CG476_RS21555	COG1435	thymidine kinase activity
CG476_RS21565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CG476_RS21570	COG1494	fructose-1,6-bisphosphatase
CG476_RS21590	COG4821	SIS domain
CG476_RS21595	COG0504	CTP synthase activity
CG476_RS21610	COG1960	acyl-CoA dehydrogenase activity
CG476_RS21615	COG1960	acyl-CoA dehydrogenase activity
CG476_RS21620	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG476_RS21625	COG0183	Belongs to the thiolase family
CG476_RS21630	COG0247	lactate metabolic process
CG476_RS21630	COG2181	nitrate reductase activity
CG476_RS21635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG476_RS21655	COG2197	response regulator
CG476_RS21660	COG4585	Histidine kinase
CG476_RS21665	COG0842	Transport permease protein
CG476_RS21670	COG1131	(ABC) transporter
CG476_RS21675	COG0024	Methionine aminopeptidase
CG476_RS21680	COG2234	aminopeptidase activity
CG476_RS21695	COG4506	Protein conserved in bacteria
CG476_RS21700	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG476_RS21715	COG0010	Belongs to the arginase family
CG476_RS21720	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CG476_RS21725	COG2814	Major facilitator Superfamily
CG476_RS21730	COG0789	Transcriptional regulator
CG476_RS21735	COG0584	glycerophosphoryl diester phosphodiesterase
CG476_RS21740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG476_RS21750	COG1994	Peptidase M50
CG476_RS21760	COG1078	dGTPase activity
CG476_RS21765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG476_RS21770	COG1120	ATPase activity
CG476_RS21775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_RS21780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_RS21785	COG4844	belongs to the
CG476_RS21800	COG0280	phosphate acetyltransferase
CG476_RS21805	COG3253	May function as heme-dependent peroxidase
CG476_RS21815	COG3773	Cell wall hydrolase
CG476_RS21825	COG2363	Small membrane protein
CG476_RS21835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG476_RS21840	COG2233	PERMEase
CG476_RS21845	COG0561	phosphatase activity
CG476_RS21850	COG2814	Major facilitator Superfamily
CG476_RS21855	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CG476_RS21860	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG476_RS21865	COG1131	(ABC) transporter
CG476_RS21870	COG2755	lipolytic protein G-D-S-L family
CG476_RS21875	COG0460	homoserine dehydrogenase
CG476_RS21880	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CG476_RS21885	COG2873	o-acetylhomoserine
CG476_RS21895	COG0351	phosphomethylpyrimidine kinase
CG476_RS21905	COG1966	Carbon starvation protein
CG476_RS21910	COG3279	Response regulator of the LytR AlgR family
CG476_RS21915	COG0477	Major facilitator Superfamily
CG476_RS21925	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CG476_RS21930	COG0438	transferase activity, transferring glycosyl groups
CG476_RS21945	COG0840	transmembrane signaling receptor activity
CG476_RS21960	COG1607	acyl-coa hydrolase
CG476_RS21965	COG1216	Glycosyl transferase, family 2
CG476_RS21980	COG0463	Glycosyl transferase, family 2
CG476_RS21995	COG0463	Glycosyl transferase, family 2
CG476_RS22000	COG0488	(ABC) transporter
CG476_RS22005	COG1309	transcriptional regulator
CG476_RS22010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG476_RS22015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG476_RS22015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG476_RS22020	COG0628	permease
CG476_RS22025	COG1346	cytolysis
CG476_RS22035	COG3279	Response regulator of the LytR AlgR family
CG476_RS22040	COG3275	phosphorelay sensor kinase activity
CG476_RS22045	COG2814	Major facilitator Superfamily
CG476_RS22050	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CG476_RS22055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG476_RS22065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG476_RS22070	COG3711	transcriptional antiterminator
CG476_RS22070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_RS22130	COG0582	viral genome integration into host DNA
CG476_RS22145	COG1132	(ABC) transporter
CG476_RS22155	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CG476_RS22165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG476_RS22170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CG476_RS22175	COG4853	Protein conserved in bacteria
CG476_RS22185	COG5002	protein histidine kinase activity
CG476_RS22190	COG0745	RESPONSE REGULATOR receiver
CG476_RS22215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CG476_RS22220	COG0305	Participates in initiation and elongation during chromosome replication
CG476_RS22225	COG0359	binds to the 23S rRNA
CG476_RS22230	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CG476_RS22235	COG4241	membrane
CG476_RS22240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CG476_RS22250	COG0360	Binds together with S18 to 16S ribosomal RNA
CG476_RS22255	COG0012	GTP binding
CG476_RS22260	COG4481	Protein conserved in bacteria
CG476_RS22265	COG0668	transmembrane transport
CG476_RS22275	COG1475	DNA binding
CG476_RS22280	COG1192	Involved in chromosome partitioning
CG476_RS22285	COG1475	DNA binding
CG476_RS22290	COG0357	Ribosomal RNA small subunit methyltransferase G
CG476_RS22295	COG0445	tRNA wobble uridine modification
CG476_RS22300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CG476_RS22305	COG1847	R3H domain protein
CG476_RS22310	COG0706	membrane insertase activity
CG476_RS22315	COG0594	ribonuclease P activity
CG476_RS22320	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CG476_RS22455	COG3209	COG3209 Rhs family protein
CG476_RS22460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CG476_RS22495	COG0457	Tetratricopeptide repeat
CG476_RS22530	COG1073	alpha beta
CG476_RS22540	COG2197	response regulator
CG476_RS22545	COG1476	TRANSCRIPTIONal
CG476_RS22720	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_RS22740	COG0583	DNA-binding transcription factor activity
CG476_RS22755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG476_RS22835	COG4974	Belongs to the 'phage' integrase family
CG476_RS22870	COG4166	transmembrane transport
CG476_RS22880	COG0457	Tetratricopeptide repeat
CG476_RS22920	COG1192	Involved in chromosome partitioning
CG476_RS23070	COG0791	NLP P60 protein
CG476_RS23070	COG0741	lytic transglycosylase activity