locus-tag	class	description
CG477_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CG477_RS00010	COG0592	DNA-directed DNA polymerase activity
CG477_RS00015	COG2501	S4 domain
CG477_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CG477_RS00025	COG0187	DNA topoisomerase II activity
CG477_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG477_RS00065	COG0517	IMP dehydrogenase activity
CG477_RS00065	COG0516	GMP reductase activity
CG477_RS00070	COG1686	Belongs to the peptidase S11 family
CG477_RS00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CG477_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CG477_RS00085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CG477_RS00100	COG1428	Deoxynucleoside kinase
CG477_RS00105	COG1428	Deoxynucleoside kinase
CG477_RS00110	COG1335	isochorismatase
CG477_RS00115	COG0590	tRNA wobble adenosine to inosine editing
CG477_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CG477_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CG477_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CG477_RS00180	COG1982	Orn Lys Arg decarboxylase major
CG477_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CG477_RS00190	COG0470	DNA polymerase III
CG477_RS00195	COG1774	PSP1 C-terminal conserved region
CG477_RS00200	COG4467	Involved in initiation control of chromosome replication
CG477_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CG477_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CG477_RS00220	COG2002	toxin-antitoxin pair type II binding
CG477_RS00230	COG0084	hydrolase, TatD family'
CG477_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CG477_RS00250	COG4466	Protein conserved in bacteria
CG477_RS00260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CG477_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG477_RS00270	COG0251	oxidation-reduction process
CG477_RS00275	COG2088	sporulation resulting in formation of a cellular spore
CG477_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CG477_RS00290	COG0193	aminoacyl-tRNA hydrolase activity
CG477_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CG477_RS00305	COG2002	toxin-antitoxin pair type II binding
CG477_RS00310	COG2244	polysaccharide biosynthetic process
CG477_RS00315	COG3956	TIGRFAM MazG family protein
CG477_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CG477_RS00340	COG1098	S1 RNA binding domain
CG477_RS00355	COG2208	phosphoserine phosphatase activity
CG477_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CG477_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CG477_RS00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CG477_RS00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CG477_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG477_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CG477_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
CG477_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG477_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CG477_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CG477_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CG477_RS00420	COG1396	sequence-specific DNA binding
CG477_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG477_RS00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CG477_RS00465	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG477_RS00515	COG3880	PFAM UvrB UvrC protein
CG477_RS00520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CG477_RS00525	COG0542	response to heat
CG477_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CG477_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
CG477_RS00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CG477_RS00550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CG477_RS00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CG477_RS00560	COG1045	serine acetyltransferase
CG477_RS00565	COG0215	cysteine-tRNA ligase activity
CG477_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG477_RS00580	COG3688	RNA-binding protein containing a PIN domain
CG477_RS00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG477_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
CG477_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CG477_RS00610	COG0081	regulation of translation
CG477_RS00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CG477_RS00620	COG0222	ribosome binding
CG477_RS00625	COG2813	Specifically methylates the guanine in position
CG477_RS00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CG477_RS00640	COG1358	cellular component organization or biogenesis
CG477_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CG477_RS00650	COG0049	tRNA binding
CG477_RS00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CG477_RS00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CG477_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CG477_RS00675	COG0088	Forms part of the polypeptide exit tunnel
CG477_RS00680	COG0089	rRNA binding
CG477_RS00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CG477_RS00690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CG477_RS00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CG477_RS00700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CG477_RS00705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CG477_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
CG477_RS00715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CG477_RS00720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CG477_RS00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CG477_RS00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CG477_RS00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CG477_RS00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CG477_RS00755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CG477_RS00760	COG1841	ribosomal large subunit assembly
CG477_RS00765	COG0200	Binds to the 23S rRNA
CG477_RS00770	COG0201	protein transport
CG477_RS00775	COG0563	adenylate kinase activity
CG477_RS00780	COG0024	Methionine aminopeptidase
CG477_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CG477_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CG477_RS00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CG477_RS00805	COG0202	RNA polymerase activity
CG477_RS00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG477_RS00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CG477_RS00845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CG477_RS00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG477_RS00860	COG0489	protein tyrosine kinase activity
CG477_RS00870	COG2194	sulfuric ester hydrolase activity
CG477_RS00875	COG0726	polysaccharide deacetylase
CG477_RS00905	COG4974	Belongs to the 'phage' integrase family
CG477_RS01060	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CG477_RS01070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG477_RS01105	COG1396	sequence-specific DNA binding
CG477_RS01110	COG0602	queuosine metabolic process
CG477_RS01220	COG3681	Belongs to the UPF0597 family
CG477_RS01225	COG3681	Belongs to the UPF0597 family
CG477_RS01250	COG2814	Major facilitator Superfamily
CG477_RS01260	COG0601	transmembrane transport
CG477_RS01265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG477_RS01270	COG0444	Belongs to the ABC transporter superfamily
CG477_RS01275	COG4608	Belongs to the ABC transporter superfamily
CG477_RS01280	COG4166	transmembrane transport
CG477_RS01290	COG2207	Transcriptional regulator
CG477_RS01300	COG1309	transcriptional regulator
CG477_RS01310	COG0656	L-ascorbic acid biosynthetic process
CG477_RS01315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG477_RS01325	COG4149	molybdate abc transporter
CG477_RS01330	COG0725	ABC transporter, periplasmic molybdate-binding protein
CG477_RS01335	COG1910	domain protein
CG477_RS01340	COG0204	Acyl-transferase
CG477_RS01345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_RS01350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG477_RS01350	COG1648	precorrin-2 dehydrogenase activity
CG477_RS01360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG477_RS01360	COG1587	Uroporphyrinogen-III synthase
CG477_RS01365	COG2146	nitrite reductase [NAD(P)H] activity
CG477_RS01370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG477_RS01400	COG4585	Histidine kinase
CG477_RS01405	COG2197	response regulator
CG477_RS01410	COG1131	(ABC) transporter
CG477_RS01415	COG1511	domain protein
CG477_RS01415	COG0842	Transport permease protein
CG477_RS01420	COG0842	Transport permease protein
CG477_RS01430	COG0747	negative chemotaxis
CG477_RS01435	COG0601	transmembrane transport
CG477_RS01440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG477_RS01445	COG0444	Belongs to the ABC transporter superfamily
CG477_RS01450	COG4608	Belongs to the ABC transporter superfamily
CG477_RS01455	COG0561	phosphatase activity
CG477_RS01475	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CG477_RS01480	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG477_RS01490	COG2814	Major facilitator Superfamily
CG477_RS01495	COG1181	Belongs to the D-alanine--D-alanine ligase family
CG477_RS01500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CG477_RS01510	COG0705	Rhomboid family
CG477_RS01510	COG0457	Tetratricopeptide repeat
CG477_RS01515	COG0736	holo-[acyl-carrier-protein] synthase activity
CG477_RS01520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CG477_RS01530	COG0864	Transcriptional regulator
CG477_RS01535	COG2337	Toxic component of a toxin-antitoxin (TA) module
CG477_RS01540	COG2183	response to ionizing radiation
CG477_RS01550	COG3091	SprT-like family
CG477_RS01590	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG477_RS01640	COG0802	atpase or kinase
CG477_RS01645	COG1214	PFAM Peptidase M22, glycoprotease
CG477_RS01650	COG0456	acetyltransferase
CG477_RS01660	COG0488	(ABC) transporter
CG477_RS01665	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CG477_RS01675	COG1266	CAAX protease self-immunity
CG477_RS01680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CG477_RS01685	COG0459	protein refolding
CG477_RS01690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CG477_RS01690	COG0519	Catalyzes the synthesis of GMP from XMP
CG477_RS01695	COG2252	PERMEase
CG477_RS01705	COG5002	protein histidine kinase activity
CG477_RS01775	COG2205	protein histidine kinase activity
CG477_RS01780	COG0745	RESPONSE REGULATOR receiver
CG477_RS01800	COG0697	spore germination
CG477_RS01825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CG477_RS01830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CG477_RS01835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CG477_RS01840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CG477_RS01845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG477_RS01850	COG0047	phosphoribosylformylglycinamidine synthase activity
CG477_RS01855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG477_RS01860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CG477_RS01865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CG477_RS01870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CG477_RS01875	COG0138	bifunctional purine biosynthesis protein purh
CG477_RS01880	COG0151	Belongs to the GarS family
CG477_RS01890	COG0583	DNA-binding transcription factor activity
CG477_RS01910	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CG477_RS01915	COG0210	DNA helicase
CG477_RS01920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CG477_RS01925	COG4851	CamS sex pheromone cAM373 precursor
CG477_RS01935	COG1012	belongs to the aldehyde dehydrogenase family
CG477_RS01940	COG1335	isochorismatase
CG477_RS01950	COG2011	ABC-type metal ion transport system permease component
CG477_RS01955	COG1464	Belongs to the NlpA lipoprotein family
CG477_RS01970	COG4682	membrane
CG477_RS01975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG477_RS01980	COG0154	amidase activity
CG477_RS01985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG477_RS01990	COG1597	lipid kinase activity
CG477_RS01995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CG477_RS02000	COG0546	phosphoglycolate phosphatase activity
CG477_RS02005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CG477_RS02015	COG0531	amino acid
CG477_RS02020	COG1012	belongs to the aldehyde dehydrogenase family
CG477_RS02025	COG2076	Multidrug Resistance protein
CG477_RS02030	COG2309	aminopeptidase activity
CG477_RS02045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG477_RS02050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG477_RS02055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG477_RS02070	COG0450	alkyl hydroperoxide reductase
CG477_RS02095	COG0714	Associated with various cellular activities
CG477_RS02130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_RS02135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_RS02140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG477_RS02145	COG0492	ferredoxin-NADP+ reductase activity
CG477_RS02155	COG0166	Belongs to the GPI family
CG477_RS02160	COG5002	protein histidine kinase activity
CG477_RS02185	COG3541	Predicted nucleotidyltransferase
CG477_RS02190	COG2814	Major facilitator Superfamily
CG477_RS02195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG477_RS02195	COG0723	plastoquinol--plastocyanin reductase activity
CG477_RS02205	COG0765	amino acid transport
CG477_RS02210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG477_RS02220	COG0840	transmembrane signaling receptor activity
CG477_RS02235	COG2235	arginine
CG477_RS02250	COG0549	Belongs to the carbamate kinase family
CG477_RS02255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG477_RS02265	COG0366	Alpha amylase catalytic
CG477_RS02270	COG2190	(PTS) system
CG477_RS02270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG477_RS02270	COG1263	PTS System
CG477_RS02290	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_RS02295	COG4605	iron ion homeostasis
CG477_RS02300	COG4604	ABC transporter, ATP-binding protein
CG477_RS02305	COG4607	ABC-type enterochelin transport system periplasmic component
CG477_RS02310	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CG477_RS02315	COG0352	thiamine-phosphate diphosphorylase activity
CG477_RS02320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CG477_RS02340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG477_RS02350	COG1116	anion transmembrane transporter activity
CG477_RS02430	COG2963	transposase activity
CG477_RS02435	COG2801	Transposase and inactivated derivatives
CG477_RS02445	COG2270	Major facilitator Superfamily
CG477_RS02470	COG2310	stress, protein
CG477_RS02475	COG2310	stress, protein
CG477_RS02480	COG2310	stress, protein
CG477_RS02485	COG0861	Integral membrane protein TerC family
CG477_RS02495	COG3853	Toxic anion resistance protein (TelA)
CG477_RS02505	COG4840	Belongs to the UPF0435 family
CG477_RS02510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG477_RS02520	COG1295	ribonuclease BN
CG477_RS02525	COG2217	Heavy metal translocating P-type atpase
CG477_RS02530	COG0697	spore germination
CG477_RS02540	COG0681	Belongs to the peptidase S26 family
CG477_RS02550	COG0586	Pfam SNARE associated Golgi protein
CG477_RS02565	COG0387	Pfam Sodium calcium exchanger
CG477_RS02575	COG0535	radical SAM domain protein
CG477_RS02595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CG477_RS02620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG477_RS02645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG477_RS02675	COG2066	Belongs to the glutaminase family
CG477_RS02680	COG1263	PTS System
CG477_RS02680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG477_RS02685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG477_RS02695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG477_RS02695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG477_RS02705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CG477_RS02710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG477_RS02725	COG0402	S-adenosylhomocysteine deaminase activity
CG477_RS02730	COG2137	regulation of response to DNA damage stimulus
CG477_RS02755	COG1988	membrane-bound metal-dependent
CG477_RS02760	COG1194	a g-specific adenine glycosylase
CG477_RS02785	COG3557	Belongs to the UPF0374 family
CG477_RS02790	COG1132	(ABC) transporter
CG477_RS02795	COG4129	membrane
CG477_RS02800	COG0069	glutamate synthase activity
CG477_RS02800	COG0067	glutamate synthase
CG477_RS02800	COG0070	glutamate synthase
CG477_RS02805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG477_RS02810	COG4555	ABC transporter
CG477_RS02830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CG477_RS02835	COG0735	belongs to the Fur family
CG477_RS02935	COG3157	Type VI secretion system effector, Hcp
CG477_RS02955	COG0457	Tetratricopeptide repeat
CG477_RS02960	COG0217	transcriptional regulatory protein
CG477_RS02965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CG477_RS02970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CG477_RS02990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CG477_RS03000	COG2766	serine protein kinase
CG477_RS03010	COG2718	Belongs to the UPF0229 family
CG477_RS03025	COG1280	lysine exporter protein (LysE YggA)
CG477_RS03065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG477_RS03075	COG1585	Membrane protein implicated in regulation of membrane protease activity
CG477_RS03080	COG2268	Band 7 protein
CG477_RS03105	COG4990	cell redox homeostasis
CG477_RS03115	COG3290	protein histidine kinase activity
CG477_RS03120	COG4565	transcriptional regulatory protein
CG477_RS03125	COG3493	citrate carrier protein
CG477_RS03130	COG0281	malic enzyme
CG477_RS03145	COG5002	protein histidine kinase activity
CG477_RS03150	COG0745	RESPONSE REGULATOR receiver
CG477_RS03160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CG477_RS03165	COG3383	formate dehydrogenase (NAD+) activity
CG477_RS03170	COG2427	Protein of unknown function (DUF1641)
CG477_RS03180	COG0840	transmembrane signaling receptor activity
CG477_RS03190	COG0531	amino acid
CG477_RS03205	COG0640	Transcriptional regulator
CG477_RS03210	COG2217	Heavy metal translocating P-type atpase
CG477_RS03215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CG477_RS03225	COG3227	Zinc metalloprotease (Elastase)
CG477_RS03240	COG2217	Heavy metal translocating P-type atpase
CG477_RS03260	COG2720	vancomycin resistance protein
CG477_RS03265	COG1316	TRANSCRIPTIONal
CG477_RS03275	COG1253	flavin adenine dinucleotide binding
CG477_RS03280	COG1027	Aspartate ammonia-lyase
CG477_RS03285	COG1620	l-lactate permease
CG477_RS03305	COG3104	oligopeptide transport
CG477_RS03310	COG0156	8-amino-7-oxononanoate synthase activity
CG477_RS03315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG477_RS03330	COG4548	von Willebrand factor, type A
CG477_RS03335	COG0714	Associated with various cellular activities
CG477_RS03340	COG0531	amino acid
CG477_RS03345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG477_RS03350	COG1115	amino acid carrier protein
CG477_RS03360	COG1126	abc transporter atp-binding protein
CG477_RS03365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG477_RS03370	COG0765	amino acid transport
CG477_RS03375	COG0765	amino acid transport
CG477_RS03380	COG0833	amino acid
CG477_RS03390	COG5002	protein histidine kinase activity
CG477_RS03395	COG0745	RESPONSE REGULATOR receiver
CG477_RS03405	COG0659	secondary active sulfate transmembrane transporter activity
CG477_RS03410	COG0589	response to stress
CG477_RS03420	COG0747	negative chemotaxis
CG477_RS03430	COG0601	transmembrane transport
CG477_RS03435	COG4608	Belongs to the ABC transporter superfamily
CG477_RS03445	COG2271	Major facilitator Superfamily
CG477_RS03450	COG1846	Transcriptional regulator
CG477_RS03455	COG0477	Major facilitator Superfamily
CG477_RS03460	COG1609	Transcriptional regulator
CG477_RS03465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG477_RS03470	COG1869	D-ribose catabolic process
CG477_RS03480	COG1172	Belongs to the binding-protein-dependent transport system permease family
CG477_RS03485	COG1879	ABC-type sugar transport system periplasmic component
CG477_RS03490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CG477_RS03530	COG3568	Endonuclease Exonuclease Phosphatase
CG477_RS03555	COG0840	transmembrane signaling receptor activity
CG477_RS03560	COG3584	3D domain protein
CG477_RS03560	COG1388	LysM domain
CG477_RS03565	COG1476	TRANSCRIPTIONal
CG477_RS03600	COG1114	Component of the transport system for branched-chain amino acids
CG477_RS03610	COG1113	amino acid transport
CG477_RS03615	COG2153	protein acetylation
CG477_RS03625	COG0569	domain protein
CG477_RS03625	COG0475	glutathione-regulated potassium exporter activity
CG477_RS03640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CG477_RS03645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CG477_RS03650	COG0833	amino acid
CG477_RS03655	COG4990	cell redox homeostasis
CG477_RS03670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_RS03675	COG0697	spore germination
CG477_RS03680	COG0531	amino acid
CG477_RS03690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG477_RS03695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG477_RS03700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG477_RS03700	COG1918	ferrous iron import across plasma membrane
CG477_RS03705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG477_RS03710	COG0573	inorganic phosphate transmembrane transporter activity
CG477_RS03715	COG0581	inorganic phosphate transmembrane transporter activity
CG477_RS03720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG477_RS03760	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG477_RS03845	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CG477_RS03870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG477_RS03875	COG1116	anion transmembrane transporter activity
CG477_RS03880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG477_RS03885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG477_RS03890	COG0352	thiamine-phosphate diphosphorylase activity
CG477_RS03895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG477_RS03900	COG2104	thiamine diphosphate biosynthetic process
CG477_RS03905	COG2022	thiamine diphosphate biosynthetic process
CG477_RS03910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG477_RS03915	COG0351	phosphomethylpyrimidine kinase
CG477_RS03945	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CG477_RS03950	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CG477_RS03955	COG2205	protein histidine kinase activity
CG477_RS03965	COG4974	Belongs to the 'phage' integrase family
CG477_RS03975	COG2816	NAD+ diphosphatase activity
CG477_RS03985	COG0735	belongs to the Fur family
CG477_RS04010	COG1846	Transcriptional regulator
CG477_RS04020	COG2252	PERMEase
CG477_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS04030	COG1376	ErfK ybiS ycfS ynhG family protein
CG477_RS04085	COG0778	Nitroreductase
CG477_RS04095	COG2719	SpoVR family
CG477_RS04105	COG1316	TRANSCRIPTIONal
CG477_RS04110	COG1283	sodium-dependent phosphate transmembrane transporter activity
CG477_RS04125	COG0577	efflux transmembrane transporter activity
CG477_RS04130	COG1136	(ABC) transporter
CG477_RS04140	COG1114	Component of the transport system for branched-chain amino acids
CG477_RS04145	COG3546	catalase activity
CG477_RS04195	COG0475	glutathione-regulated potassium exporter activity
CG477_RS04200	COG1737	Transcriptional regulator
CG477_RS04210	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CG477_RS04215	COG1263	PTS System
CG477_RS04215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG477_RS04260	COG1522	sequence-specific DNA binding
CG477_RS04275	COG0531	amino acid
CG477_RS04285	COG1012	belongs to the aldehyde dehydrogenase family
CG477_RS04295	COG1132	(ABC) transporter
CG477_RS04300	COG1132	(ABC) transporter
CG477_RS04310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG477_RS04315	COG0765	amino acid transport
CG477_RS04320	COG1126	abc transporter atp-binding protein
CG477_RS04335	COG0189	ligase activity
CG477_RS04340	COG4399	Belongs to the UPF0754 family
CG477_RS04345	COG3679	Belongs to the UPF0342 family
CG477_RS04350	COG4585	Histidine kinase
CG477_RS04355	COG2197	response regulator
CG477_RS04415	COG2094	Belongs to the DNA glycosylase MPG family
CG477_RS04420	COG0561	phosphatase activity
CG477_RS04430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG477_RS04435	COG0318	PFAM AMP-dependent synthetase and ligase
CG477_RS04460	COG2244	polysaccharide biosynthetic process
CG477_RS04470	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG477_RS04490	COG1696	Membrane protein involved in D-alanine export
CG477_RS04505	COG1024	Enoyl-CoA hydratase
CG477_RS04515	COG1363	Peptidase, m42
CG477_RS04530	COG2239	Acts as a magnesium transporter
CG477_RS04535	COG0772	Belongs to the SEDS family
CG477_RS04540	COG1115	amino acid carrier protein
CG477_RS04650	COG1476	TRANSCRIPTIONal
CG477_RS04690	COG1131	(ABC) transporter
CG477_RS04735	COG0494	nUDIX hydrolase
CG477_RS04750	COG1061	Type III restriction enzyme res subunit
CG477_RS04760	COG3829	transcription factor binding
CG477_RS04765	COG4638	Rieske (2fe-2S)
CG477_RS04770	COG1012	belongs to the aldehyde dehydrogenase family
CG477_RS04775	COG0473	3-isopropylmalate dehydrogenase activity
CG477_RS04785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_RS04795	COG1064	alcohol dehydrogenase
CG477_RS04810	COG3246	L-lysine catabolic process to acetate
CG477_RS04855	COG4641	Protein conserved in bacteria
CG477_RS04870	COG3711	transcriptional antiterminator
CG477_RS04875	COG2190	(PTS) system
CG477_RS04875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG477_RS04875	COG1263	PTS System
CG477_RS04880	COG2723	6-phospho-beta-galactosidase activity
CG477_RS04890	COG2376	Dihydroxyacetone kinase
CG477_RS04925	COG0420	3'-5' exonuclease activity
CG477_RS04930	COG4717	serine-type aminopeptidase activity
CG477_RS04935	COG3481	metal-dependent phosphohydrolase, HD sub domain
CG477_RS04950	COG0577	efflux transmembrane transporter activity
CG477_RS04955	COG1136	(ABC) transporter
CG477_RS04960	COG5002	protein histidine kinase activity
CG477_RS04965	COG0745	RESPONSE REGULATOR receiver
CG477_RS04975	COG1316	TRANSCRIPTIONal
CG477_RS04990	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CG477_RS04995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG477_RS05000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CG477_RS05005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CG477_RS05030	COG1846	Transcriptional regulator
CG477_RS05035	COG4980	gas vesicle protein
CG477_RS05045	COG0537	adenosine 5'-monophosphoramidase activity
CG477_RS05055	COG1131	(ABC) transporter
CG477_RS05060	COG4473	ABC transporter
CG477_RS05080	COG3402	PFAM membrane-flanked domain
CG477_RS05090	COG2329	Antibiotic biosynthesis monooxygenase
CG477_RS05095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG477_RS05100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CG477_RS05105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CG477_RS05110	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CG477_RS05140	COG1309	transcriptional regulator
CG477_RS05150	COG1216	Glycosyl transferase, family 2
CG477_RS05150	COG0438	transferase activity, transferring glycosyl groups
CG477_RS05160	COG1609	Transcriptional regulator
CG477_RS05170	COG1234	tRNA 3'-trailer cleavage
CG477_RS05175	COG0095	Lipoate-protein ligase
CG477_RS05185	COG0318	PFAM AMP-dependent synthetase and ligase
CG477_RS05200	COG2205	protein histidine kinase activity
CG477_RS05205	COG0745	RESPONSE REGULATOR receiver
CG477_RS05225	COG0501	Belongs to the peptidase M48B family
CG477_RS05230	COG0840	transmembrane signaling receptor activity
CG477_RS05235	COG0697	spore germination
CG477_RS05250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CG477_RS05255	COG2224	Isocitrate lyase
CG477_RS05260	COG1278	Cold shock
CG477_RS05265	COG4903	ComK protein
CG477_RS05270	COG0398	Pfam SNARE associated Golgi protein
CG477_RS05280	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CG477_RS05285	COG1074	ATP-dependent DNA helicase activity
CG477_RS05325	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG477_RS05345	COG0367	asparagine synthase
CG477_RS05355	COG0753	catalase activity
CG477_RS05365	COG1874	Beta-galactosidase
CG477_RS05365	COG0366	Alpha amylase catalytic
CG477_RS05370	COG1666	GTP binding
CG477_RS05375	COG2996	Protein conserved in bacteria
CG477_RS05390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_RS05405	COG0561	phosphatase activity
CG477_RS05425	COG2267	carboxylic ester hydrolase activity
CG477_RS05440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG477_RS05445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CG477_RS05450	COG5504	Zn-dependent protease
CG477_RS05465	COG0180	Tryptophanyl-tRNA synthetase
CG477_RS05485	COG4166	transmembrane transport
CG477_RS05490	COG0601	transmembrane transport
CG477_RS05495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG477_RS05500	COG0444	Belongs to the ABC transporter superfamily
CG477_RS05505	COG4608	Belongs to the ABC transporter superfamily
CG477_RS05510	COG0534	Mate efflux family protein
CG477_RS05515	COG4166	transmembrane transport
CG477_RS05535	COG0861	Integral membrane protein TerC family
CG477_RS05555	COG1164	Oligoendopeptidase f
CG477_RS05565	COG2346	COG2346, Truncated hemoglobins
CG477_RS05570	COG4116	CYTH
CG477_RS05580	COG2357	RelA SpoT domain protein
CG477_RS05590	COG0564	pseudouridine synthase activity
CG477_RS05600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG477_RS05605	COG0772	Belongs to the SEDS family
CG477_RS05650	COG1216	Glycosyl transferase, family 2
CG477_RS05670	COG0457	Tetratricopeptide repeat
CG477_RS05670	COG0463	Glycosyl transferase, family 2
CG477_RS05690	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CG477_RS05705	COG1091	dTDP-4-dehydrorhamnose reductase activity
CG477_RS05730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CG477_RS05735	COG2382	esterase
CG477_RS05750	COG5492	domain, Protein
CG477_RS05755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_RS05770	COG1620	l-lactate permease
CG477_RS05775	COG5634	Uncharacterized conserved protein (DUF2278)
CG477_RS05815	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG477_RS05820	COG0567	Dehydrogenase, E1 component
CG477_RS05830	COG0583	DNA-binding transcription factor activity
CG477_RS05835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG477_RS05840	COG1012	belongs to the aldehyde dehydrogenase family
CG477_RS05855	COG0196	riboflavin kinase activity
CG477_RS05860	COG3162	membrane
CG477_RS05865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_RS05870	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG477_RS05885	COG0457	Tetratricopeptide repeat
CG477_RS05950	COG0673	inositol 2-dehydrogenase activity
CG477_RS05980	COG0457	Tetratricopeptide repeat
CG477_RS05985	COG0582	viral genome integration into host DNA
CG477_RS06025	COG1686	Belongs to the peptidase S11 family
CG477_RS06030	COG0681	Belongs to the peptidase S26 family
CG477_RS06065	COG1012	belongs to the aldehyde dehydrogenase family
CG477_RS06075	COG1176	ABC-type spermidine putrescine transport system, permease component I
CG477_RS06080	COG1177	transmembrane transport
CG477_RS06085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CG477_RS06090	COG0671	phosphoesterase, PA-phosphatase related
CG477_RS06095	COG2409	Drug exporters of the RND superfamily
CG477_RS06105	COG0564	pseudouridine synthase activity
CG477_RS06115	COG2340	Cysteine-rich secretory protein family
CG477_RS06120	COG0247	lactate metabolic process
CG477_RS06125	COG0277	FAD linked oxidase domain protein
CG477_RS06130	COG3835	regulator
CG477_RS06140	COG0745	RESPONSE REGULATOR receiver
CG477_RS06145	COG5002	protein histidine kinase activity
CG477_RS06150	COG2186	Transcriptional regulator
CG477_RS06155	COG0247	lactate metabolic process
CG477_RS06160	COG1139	Iron-sulfur cluster binding protein
CG477_RS06165	COG1556	Lactate utilization protein
CG477_RS06170	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CG477_RS06175	COG0584	glycerophosphoryl diester phosphodiesterase
CG477_RS06190	COG2267	carboxylic ester hydrolase activity
CG477_RS06195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG477_RS06225	COG2116	formate transmembrane transporter activity
CG477_RS06230	COG0861	Integral membrane protein TerC family
CG477_RS06235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG477_RS06245	COG2030	dehydratase
CG477_RS06265	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS06270	COG3243	poly(R)-hydroxyalkanoic acid synthase
CG477_RS06275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG477_RS06290	COG1840	ABC-type Fe3 transport system, periplasmic component
CG477_RS06295	COG3842	ATPase activity
CG477_RS06305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG477_RS06310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CG477_RS06315	COG1349	DNA-binding transcription factor activity
CG477_RS06320	COG0235	Class ii aldolase
CG477_RS06330	COG2861	carbohydrate metabolic process
CG477_RS06340	COG3852	Histidine kinase
CG477_RS06345	COG1846	Transcriptional regulator
CG477_RS06365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CG477_RS06370	COG0720	synthase
CG477_RS06380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CG477_RS06385	COG4873	Protein conserved in bacteria
CG477_RS06395	COG0456	acetyltransferase
CG477_RS06415	COG1780	Probably involved in ribonucleotide reductase function
CG477_RS06435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CG477_RS06440	COG1725	Transcriptional regulator
CG477_RS06445	COG1131	(ABC) transporter
CG477_RS06455	COG1131	(ABC) transporter
CG477_RS06460	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG477_RS06475	COG1522	sequence-specific DNA binding
CG477_RS06490	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG477_RS06495	COG2070	2-Nitropropane dioxygenase
CG477_RS06500	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CG477_RS06510	COG1696	Membrane protein involved in D-alanine export
CG477_RS06515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG477_RS06530	COG0716	FMN binding
CG477_RS06555	COG1368	sulfuric ester hydrolase activity
CG477_RS06565	COG3173	Aminoglycoside phosphotransferase
CG477_RS06575	COG5609	conserved protein (DUF2294)
CG477_RS06580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG477_RS06585	COG3002	Belongs to the UPF0753 family
CG477_RS06590	COG0288	reversible hydration of carbon dioxide
CG477_RS06595	COG0534	Mate efflux family protein
CG477_RS06610	COG1846	Transcriptional regulator
CG477_RS06620	COG1301	dicarboxylic acid transport
CG477_RS06625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG477_RS06635	COG3874	Sporulation protein YtfJ
CG477_RS06665	COG0028	Belongs to the TPP enzyme family
CG477_RS06670	COG0440	acetolactate synthase activity
CG477_RS06675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CG477_RS06680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG477_RS06690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CG477_RS06695	COG0066	3-isopropylmalate dehydratase activity
CG477_RS06705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CG477_RS06715	COG0131	Imidazoleglycerol-phosphate dehydratase
CG477_RS06720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CG477_RS06725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CG477_RS06730	COG0107	imidazoleglycerol-phosphate synthase activity
CG477_RS06735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CG477_RS06740	COG0140	phosphoribosyl-ATP diphosphatase activity
CG477_RS06755	COG1183	phosphatidylcholine synthase activity
CG477_RS06760	COG1368	sulfuric ester hydrolase activity
CG477_RS06780	COG0175	sulfate reduction
CG477_RS06785	COG2046	Belongs to the sulfate adenylyltransferase family
CG477_RS06790	COG0529	Catalyzes the synthesis of activated sulfate
CG477_RS06795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG477_RS06815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG477_RS06815	COG1648	precorrin-2 dehydrogenase activity
CG477_RS06820	COG0733	neurotransmitter:sodium symporter activity
CG477_RS06835	COG3557	Belongs to the UPF0374 family
CG477_RS06840	COG1757	Na H antiporter
CG477_RS06855	COG4758	membrane
CG477_RS06860	COG4585	Histidine kinase
CG477_RS06865	COG2197	response regulator
CG477_RS06870	COG1114	Component of the transport system for branched-chain amino acids
CG477_RS06875	COG0737	Belongs to the 5'-nucleotidase family
CG477_RS06875	COG4085	toxin activity
CG477_RS06875	COG1525	nuclease
CG477_RS06905	COG3711	transcriptional antiterminator
CG477_RS06915	COG2723	6-phospho-beta-galactosidase activity
CG477_RS06930	COG3711	transcriptional antiterminator
CG477_RS06930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_RS06935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG477_RS06935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG477_RS06935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_RS06940	COG1482	cell wall glycoprotein biosynthetic process
CG477_RS06950	COG2801	Transposase and inactivated derivatives
CG477_RS06970	COG0730	response to heat
CG477_RS06975	COG0306	phosphate transporter
CG477_RS06980	COG1392	Phosphate transport regulator
CG477_RS06985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG477_RS06995	COG3852	Histidine kinase
CG477_RS07000	COG1801	Protein of unknown function DUF72
CG477_RS07010	COG0582	viral genome integration into host DNA
CG477_RS07015	COG5002	protein histidine kinase activity
CG477_RS07020	COG0813	purine-nucleoside phosphorylase activity
CG477_RS07030	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CG477_RS07030	COG0392	lysyltransferase activity
CG477_RS07045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG477_RS07050	COG1686	Belongs to the peptidase S11 family
CG477_RS07055	COG2715	membrane protein required for spore maturation
CG477_RS07060	COG0700	Nucleoside recognition
CG477_RS07065	COG1187	pseudouridine synthase activity
CG477_RS07075	COG1333	cytochrome c biogenesis protein
CG477_RS07080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG477_RS07085	COG0745	RESPONSE REGULATOR receiver
CG477_RS07090	COG5002	protein histidine kinase activity
CG477_RS07110	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CG477_RS07115	COG1141	Ferredoxin
CG477_RS07125	COG0514	ATP-dependent DNA helicase (RecQ)
CG477_RS07130	COG1266	CAAX protease self-immunity
CG477_RS07140	COG1408	metallophosphoesterase
CG477_RS07155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG477_RS07170	COG0492	ferredoxin-NADP+ reductase activity
CG477_RS07180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CG477_RS07190	COG1304	FMN binding
CG477_RS07225	COG1160	GTP binding
CG477_RS07230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CG477_RS07250	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG477_RS07260	COG0302	gtp cyclohydrolase
CG477_RS07265	COG0142	geranyltranstransferase activity
CG477_RS07270	COG2226	methyltransferase
CG477_RS07275	COG0142	geranyltranstransferase activity
CG477_RS07285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CG477_RS07290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CG477_RS07295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CG477_RS07300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CG477_RS07305	COG0457	Tetratricopeptide repeat
CG477_RS07310	COG5582	Belongs to the UPF0302 family
CG477_RS07325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CG477_RS07335	COG4347	Protein of unknown function (DUF1405)
CG477_RS07350	COG2738	Putative neutral zinc metallopeptidase
CG477_RS07360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_RS07365	COG1694	Mazg nucleotide pyrophosphohydrolase
CG477_RS07370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CG477_RS07375	COG1803	Methylglyoxal synthase
CG477_RS07380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG477_RS07385	COG0438	transferase activity, transferring glycosyl groups
CG477_RS07390	COG0617	tRNA 3'-terminal CCA addition
CG477_RS07405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CG477_RS07410	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CG477_RS07415	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CG477_RS07420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CG477_RS07420	COG1199	ATP-dependent helicase activity
CG477_RS07440	COG3935	DnaD domain protein
CG477_RS07445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CG477_RS07455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG477_RS07455	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG477_RS07460	COG3331	DNA recombination
CG477_RS07495	COG4474	Belongs to the UPF0398 family
CG477_RS07500	COG3599	regulation of cell shape
CG477_RS07510	COG0116	Belongs to the methyltransferase superfamily
CG477_RS07520	COG1199	ATP-dependent helicase activity
CG477_RS07525	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CG477_RS07535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG477_RS07540	COG2233	PERMEase
CG477_RS07545	COG2311	Membrane
CG477_RS07550	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG477_RS07560	COG0456	acetyltransferase
CG477_RS07600	COG3766	membrane
CG477_RS07610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG477_RS07615	COG1733	regulation of RNA biosynthetic process
CG477_RS07635	COG0328	RNA-DNA hybrid ribonuclease activity
CG477_RS07665	COG1278	Cold shock
CG477_RS07675	COG3162	membrane
CG477_RS07680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_RS07685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG477_RS07690	COG0475	glutathione-regulated potassium exporter activity
CG477_RS07695	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG477_RS07725	COG2323	membrane
CG477_RS07730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CG477_RS07755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG477_RS07765	COG2201	protein-glutamate methylesterase activity
CG477_RS07770	COG0643	Histidine kinase
CG477_RS07770	COG2198	Histidine kinase
CG477_RS07775	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG477_RS07775	COG1776	CheC inhibitor of MCP methylation
CG477_RS07790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CG477_RS07810	COG1256	bacterial-type flagellum assembly
CG477_RS07815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG477_RS07820	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CG477_RS07835	COG1815	bacterial-type flagellum-dependent cell motility
CG477_RS07855	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG477_RS07865	COG1157	protein secretion by the type III secretion system
CG477_RS07900	COG0835	chemotaxis
CG477_RS07900	COG0784	Response regulator, receiver
CG477_RS07910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG477_RS07915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG477_RS07920	COG0741	lytic transglycosylase activity
CG477_RS07930	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG477_RS07935	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG477_RS07935	COG1776	CheC inhibitor of MCP methylation
CG477_RS07945	COG1338	Plays a role in the flagellum-specific transport system
CG477_RS07950	COG1987	bacterial-type flagellum assembly
CG477_RS07960	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG477_RS07965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG477_RS07970	COG1419	protein localization to endoplasmic reticulum
CG477_RS07975	COG4786	Flagellar basal body rod
CG477_RS07980	COG0577	efflux transmembrane transporter activity
CG477_RS07980	COG1136	(ABC) transporter
CG477_RS08030	COG2814	Major facilitator Superfamily
CG477_RS08075	COG0367	asparagine synthase
CG477_RS08095	COG1802	Transcriptional regulator
CG477_RS08100	COG0697	spore germination
CG477_RS08110	COG1757	Na H antiporter
CG477_RS08145	COG0534	Mate efflux family protein
CG477_RS08150	COG3340	Belongs to the peptidase S51 family
CG477_RS08155	COG2733	membrane
CG477_RS08165	COG1280	lysine exporter protein (LysE YggA)
CG477_RS08170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG477_RS08185	COG2502	aspartate--ammonia ligase
CG477_RS08195	COG0109	protoheme IX farnesyltransferase activity
CG477_RS08225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG477_RS08230	COG0488	(ABC) transporter
CG477_RS08235	COG4166	transmembrane transport
CG477_RS08240	COG2223	nitrite transmembrane transporter activity
CG477_RS08245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG477_RS08250	COG2244	polysaccharide biosynthetic process
CG477_RS08255	COG0733	neurotransmitter:sodium symporter activity
CG477_RS08260	COG5566	PFAM Mor transcription activator
CG477_RS08275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG477_RS08280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG477_RS08290	COG0129	dihydroxy-acid dehydratase activity
CG477_RS08295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CG477_RS08300	COG1811	Na channel or pump
CG477_RS08325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG477_RS08330	COG2814	Major facilitator Superfamily
CG477_RS08335	COG3384	dioxygenase
CG477_RS08355	COG0402	S-adenosylhomocysteine deaminase activity
CG477_RS08360	COG4166	transmembrane transport
CG477_RS08370	COG1914	H( )-stimulated, divalent metal cation uptake system
CG477_RS08375	COG1054	Belongs to the UPF0176 family
CG477_RS08385	COG0083	homoserine kinase activity
CG477_RS08395	COG2390	Transcriptional regulator
CG477_RS08400	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CG477_RS08415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG477_RS08425	COG1510	regulation of RNA biosynthetic process
CG477_RS08430	COG1012	belongs to the aldehyde dehydrogenase family
CG477_RS08435	COG1454	alcohol dehydrogenase
CG477_RS08450	COG1012	belongs to the aldehyde dehydrogenase family
CG477_RS08455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CG477_RS08465	COG0628	permease
CG477_RS08480	COG0523	cobalamin synthesis protein
CG477_RS08505	COG1686	Belongs to the peptidase S11 family
CG477_RS08520	COG0791	NLP P60 protein
CG477_RS08520	COG1388	LysM domain
CG477_RS08525	COG0300	oxidoreductase activity
CG477_RS08535	COG0460	homoserine dehydrogenase
CG477_RS08545	COG0083	homoserine kinase activity
CG477_RS08550	COG1316	TRANSCRIPTIONal
CG477_RS08565	COG1285	pathogenesis
CG477_RS08570	COG1247	-acetyltransferase
CG477_RS08585	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG477_RS08605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CG477_RS08610	COG0577	efflux transmembrane transporter activity
CG477_RS08615	COG2409	Drug exporters of the RND superfamily
CG477_RS08620	COG1404	Belongs to the peptidase S8 family
CG477_RS08635	COG0840	transmembrane signaling receptor activity
CG477_RS08650	COG3949	Membrane
CG477_RS08655	COG0783	Belongs to the Dps family
CG477_RS08675	COG0523	cobalamin synthesis protein
CG477_RS08685	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG477_RS08700	COG1902	pentaerythritol trinitrate reductase activity
CG477_RS08705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CG477_RS08715	COG4166	transmembrane transport
CG477_RS08720	COG0346	lactoylglutathione lyase activity
CG477_RS08730	COG5337	Spore coat protein CotH
CG477_RS08735	COG1051	belongs to the nudix hydrolase family
CG477_RS08740	COG0586	Pfam SNARE associated Golgi protein
CG477_RS08745	COG2244	polysaccharide biosynthetic process
CG477_RS08755	COG0701	Predicted permease
CG477_RS08760	COG3689	TIGRFAM TIGR03943 family protein
CG477_RS08765	COG1607	acyl-coa hydrolase
CG477_RS08775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG477_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS08795	COG2839	Protein conserved in bacteria
CG477_RS08800	COG1253	flavin adenine dinucleotide binding
CG477_RS08815	COG1114	Component of the transport system for branched-chain amino acids
CG477_RS08840	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG477_RS08850	COG1876	peptidase activity
CG477_RS08905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CG477_RS08910	COG1819	glycosyl
CG477_RS08915	COG1819	glycosyl
CG477_RS08920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG477_RS08970	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG477_RS09025	COG3874	Sporulation protein YtfJ
CG477_RS09050	COG2226	methyltransferase
CG477_RS09075	COG0386	Belongs to the glutathione peroxidase family
CG477_RS09105	COG0640	Transcriptional regulator
CG477_RS09110	COG0798	PFAM Bile acid sodium symporter
CG477_RS09115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG477_RS09160	COG1418	mRNA catabolic process
CG477_RS09165	COG0488	(ABC) transporter
CG477_RS09175	COG0629	single-stranded DNA binding
CG477_RS09180	COG1413	lyase activity
CG477_RS09195	COG2136	Putative SAM-dependent methyltransferase
CG477_RS09195	COG2521	methyltransferase
CG477_RS09200	COG0018	arginyl-trna synthetase
CG477_RS09210	COG0733	neurotransmitter:sodium symporter activity
CG477_RS09215	COG0596	Alpha beta hydrolase
CG477_RS09235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG477_RS09240	COG0477	Major facilitator Superfamily
CG477_RS09265	COG2610	gluconate transmembrane transporter activity
CG477_RS09275	COG0456	acetyltransferase
CG477_RS09280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CG477_RS09290	COG1131	(ABC) transporter
CG477_RS09295	COG4473	ABC transporter
CG477_RS09310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG477_RS09315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CG477_RS09325	COG0768	penicillin binding
CG477_RS09335	COG0204	Acyl-transferase
CG477_RS09340	COG1272	protein, Hemolysin III
CG477_RS09345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CG477_RS09350	COG0805	protein transport
CG477_RS09360	COG1307	EDD domain protein, DegV family
CG477_RS09370	COG1999	signal sequence binding
CG477_RS09375	COG0071	Belongs to the small heat shock protein (HSP20) family
CG477_RS09380	COG0367	asparagine synthase
CG477_RS09395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG477_RS09420	COG0071	Belongs to the small heat shock protein (HSP20) family
CG477_RS09430	COG1737	Transcriptional regulator
CG477_RS09435	COG1070	Carbohydrate kinase
CG477_RS09445	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CG477_RS09500	COG1151	hydroxylamine reductase activity
CG477_RS09510	COG1253	flavin adenine dinucleotide binding
CG477_RS09515	COG5506	Protein of unknown function (DUF1694)
CG477_RS09535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG477_RS09540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CG477_RS09545	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CG477_RS09550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG477_RS09555	COG0456	acetyltransferase
CG477_RS09560	COG3829	transcription factor binding
CG477_RS09570	COG1509	lysine 2,3-aminomutase activity
CG477_RS09580	COG4479	Belongs to the UPF0346 family
CG477_RS09605	COG1357	PFAM Pentapeptide repeats (8 copies)
CG477_RS09605	COG0515	serine threonine protein kinase
CG477_RS09610	COG0671	phosphoesterase, PA-phosphatase related
CG477_RS09615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG477_RS09620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG477_RS09670	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CG477_RS09680	COG0726	polysaccharide deacetylase
CG477_RS09685	COG1408	metallophosphoesterase
CG477_RS09690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG477_RS09695	COG2323	membrane
CG477_RS09700	COG0671	phosphoesterase, PA-phosphatase related
CG477_RS09710	COG1280	lysine exporter protein (LysE YggA)
CG477_RS09715	COG3403	YqcI/YcgG family
CG477_RS09745	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG477_RS09745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG477_RS09755	COG0372	Belongs to the citrate synthase family
CG477_RS09760	COG2079	MmgE PrpD family protein
CG477_RS09765	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CG477_RS09770	COG1960	acyl-CoA dehydrogenase activity
CG477_RS09775	COG2084	Dehydrogenase
CG477_RS09780	COG1012	belongs to the aldehyde dehydrogenase family
CG477_RS09790	COG1280	lysine exporter protein (LysE YggA)
CG477_RS09810	COG0420	3'-5' exonuclease activity
CG477_RS09815	COG0419	ATPase involved in DNA repair
CG477_RS09820	COG3104	oligopeptide transport
CG477_RS09855	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG477_RS09860	COG1131	(ABC) transporter
CG477_RS09880	COG1131	(ABC) transporter
CG477_RS09885	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG477_RS09905	COG1942	4-Oxalocrotonate Tautomerase
CG477_RS09940	COG0457	Tetratricopeptide repeat
CG477_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS09980	COG1169	isochorismate synthase
CG477_RS09985	COG1021	2,3-dihydroxybenzoate-AMP ligase
CG477_RS09990	COG1535	isochorismatase
CG477_RS09990	COG3433	isochorismatase activity
CG477_RS09995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG477_RS10000	COG3251	PFAM MbtH domain protein
CG477_RS10005	COG2814	Major facilitator Superfamily
CG477_RS10020	COG0776	regulation of translation
CG477_RS10035	COG2329	Antibiotic biosynthesis monooxygenase
CG477_RS10040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG477_RS10080	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG477_RS10085	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CG477_RS10090	COG0667	Aldo Keto reductase
CG477_RS10110	COG0010	Belongs to the arginase family
CG477_RS10120	COG1132	(ABC) transporter
CG477_RS10125	COG1132	(ABC) transporter
CG477_RS10130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG477_RS10155	COG1649	PFAM Uncharacterised BCR, COG1649
CG477_RS10175	COG2971	BadF BadG BcrA BcrD
CG477_RS10195	COG0588	phosphoglycerate mutase activity
CG477_RS10230	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG477_RS10240	COG1960	acyl-CoA dehydrogenase activity
CG477_RS10245	COG0439	Biotin carboxylase
CG477_RS10250	COG0511	ligase activity, forming carbon-carbon bonds
CG477_RS10255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG477_RS10260	COG1024	Enoyl-CoA hydratase
CG477_RS10265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CG477_RS10270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG477_RS10280	COG1216	Glycosyl transferase, family 2
CG477_RS10285	COG0640	Transcriptional regulator
CG477_RS10295	COG1686	Belongs to the peptidase S11 family
CG477_RS10300	COG5002	protein histidine kinase activity
CG477_RS10330	COG0789	Transcriptional regulator
CG477_RS10350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG477_RS10360	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS10380	COG0475	glutathione-regulated potassium exporter activity
CG477_RS10400	COG1309	transcriptional regulator
CG477_RS10410	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS10415	COG2002	toxin-antitoxin pair type II binding
CG477_RS10435	COG0693	protein deglycase activity
CG477_RS10440	COG0201	protein transport
CG477_RS10460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG477_RS10465	COG0322	excinuclease ABC activity
CG477_RS10470	COG2318	DinB family
CG477_RS10480	COG4667	esterase of the alpha-beta hydrolase superfamily
CG477_RS10500	COG1051	belongs to the nudix hydrolase family
CG477_RS10550	COG2223	nitrite transmembrane transporter activity
CG477_RS10595	COG1216	Glycosyl transferase, family 2
CG477_RS10610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG477_RS10615	COG1279	arginine transmembrane transporter activity
CG477_RS10650	COG1794	racemase activity, acting on amino acids and derivatives
CG477_RS10660	COG2828	Protein conserved in bacteria
CG477_RS10665	COG5002	protein histidine kinase activity
CG477_RS10670	COG0561	phosphatase activity
CG477_RS10690	COG2124	cytochrome p450
CG477_RS10725	COG0457	Tetratricopeptide repeat
CG477_RS10735	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG477_RS10765	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG477_RS10770	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_RS10775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG477_RS10785	COG2959	enzyme of heme biosynthesis
CG477_RS10815	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CG477_RS10820	COG3844	kynureninase activity
CG477_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS10840	COG4176	ABC-type proline glycine betaine transport system permease component
CG477_RS10845	COG0517	IMP dehydrogenase activity
CG477_RS10845	COG4175	Glycine betaine
CG477_RS10875	COG2153	protein acetylation
CG477_RS10910	COG0514	ATP-dependent DNA helicase (RecQ)
CG477_RS10930	COG4637	Psort location Cytoplasmic, score
CG477_RS10935	COG1227	inorganic diphosphatase activity
CG477_RS10945	COG3397	chitin binding
CG477_RS10985	COG4166	transmembrane transport
CG477_RS10995	COG4948	Mandelate Racemase Muconate Lactonizing
CG477_RS11075	COG1307	EDD domain protein, DegV family
CG477_RS11120	COG5444	nuclease activity
CG477_RS11220	COG5444	nuclease activity
CG477_RS11240	COG2261	transglycosylase associated protein
CG477_RS11245	COG0675	Transposase, IS605 OrfB family
CG477_RS11270	COG0436	Aminotransferase
CG477_RS11285	COG3973	AAA domain
CG477_RS11295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG477_RS11320	COG0628	permease
CG477_RS11335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG477_RS11340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG477_RS11345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG477_RS11360	COG2746	aminoglycoside 3-N-acetyltransferase activity
CG477_RS11370	COG0456	acetyltransferase
CG477_RS11370	COG0454	-acetyltransferase
CG477_RS11395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_RS11400	COG1368	sulfuric ester hydrolase activity
CG477_RS11405	COG0488	(ABC) transporter
CG477_RS11410	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG477_RS11410	COG1605	Chorismate mutase
CG477_RS11430	COG0346	lactoylglutathione lyase activity
CG477_RS11440	COG3547	Transposase (IS116 IS110 IS902 family)
CG477_RS11445	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG477_RS11485	COG2329	Antibiotic biosynthesis monooxygenase
CG477_RS11500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG477_RS11525	COG0494	nUDIX hydrolase
CG477_RS11540	COG0456	acetyltransferase
CG477_RS11545	COG0477	Major facilitator Superfamily
CG477_RS11560	COG0697	spore germination
CG477_RS11565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG477_RS11575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG477_RS11590	COG0730	response to heat
CG477_RS11600	COG0833	amino acid
CG477_RS11625	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CG477_RS11640	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CG477_RS11645	COG1984	allophanate hydrolase subunit 2
CG477_RS11650	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CG477_RS11655	COG1414	Transcriptional regulator
CG477_RS11670	COG1960	acyl-CoA dehydrogenase activity
CG477_RS11685	COG3314	Sporulation integral membrane protein YlbJ
CG477_RS11700	COG0346	lactoylglutathione lyase activity
CG477_RS11710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG477_RS11715	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CG477_RS11720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG477_RS11725	COG0438	transferase activity, transferring glycosyl groups
CG477_RS11740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG477_RS11745	COG0438	transferase activity, transferring glycosyl groups
CG477_RS11750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG477_RS11765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CG477_RS11785	COG4851	CamS sex pheromone cAM373 precursor
CG477_RS11905	COG0477	Major facilitator Superfamily
CG477_RS11920	COG1846	Transcriptional regulator
CG477_RS11925	COG2814	Major facilitator Superfamily
CG477_RS11935	COG2031	fatty acid transporter
CG477_RS11970	COG1122	ATPase activity
CG477_RS11995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CG477_RS12010	COG1131	(ABC) transporter
CG477_RS12030	COG2365	Tyrosine phosphatase family
CG477_RS12070	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CG477_RS12075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_RS12080	COG0579	oxidoreductase
CG477_RS12085	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CG477_RS12095	COG1253	flavin adenine dinucleotide binding
CG477_RS12100	COG0789	Transcriptional regulator
CG477_RS12105	COG3813	Protein conserved in bacteria
CG477_RS12180	COG0582	viral genome integration into host DNA
CG477_RS12285	COG2072	flavoprotein involved in K transport
CG477_RS12315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG477_RS12320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG477_RS12330	COG1193	negative regulation of DNA recombination
CG477_RS12335	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CG477_RS12340	COG1164	Oligoendopeptidase f
CG477_RS12360	COG0584	glycerophosphoryl diester phosphodiesterase
CG477_RS12365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG477_RS12395	COG3397	chitin binding
CG477_RS12410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CG477_RS12415	COG0277	FAD linked oxidase domain protein
CG477_RS12420	COG1285	pathogenesis
CG477_RS12425	COG2720	vancomycin resistance protein
CG477_RS12630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CG477_RS12735	COG1484	DNA-dependent DNA replication
CG477_RS12785	COG0582	viral genome integration into host DNA
CG477_RS12810	COG1278	Cold shock
CG477_RS12820	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS12825	COG0165	Argininosuccinate lyase
CG477_RS12840	COG3409	Peptidoglycan-binding domain 1 protein
CG477_RS12855	COG4145	pantothenate transmembrane transporter activity
CG477_RS12865	COG1012	belongs to the aldehyde dehydrogenase family
CG477_RS12875	COG1657	PFAM Prenyltransferase squalene oxidase
CG477_RS12880	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CG477_RS12885	COG2962	Rard protein
CG477_RS12920	COG2226	methyltransferase
CG477_RS12925	COG4166	transmembrane transport
CG477_RS12930	COG4166	transmembrane transport
CG477_RS12935	COG1301	dicarboxylic acid transport
CG477_RS12945	COG0673	inositol 2-dehydrogenase activity
CG477_RS12950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG477_RS12955	COG0187	DNA topoisomerase II activity
CG477_RS12965	COG1832	CoA-binding protein
CG477_RS12970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG477_RS12975	COG0745	RESPONSE REGULATOR receiver
CG477_RS12990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CG477_RS12995	COG4841	protein insertion into membrane
CG477_RS13005	COG0824	Thioesterase
CG477_RS13035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG477_RS13040	COG3655	Transcriptional regulator
CG477_RS13060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CG477_RS13100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG477_RS13105	COG0318	PFAM AMP-dependent synthetase and ligase
CG477_RS13135	COG0457	Tetratricopeptide repeat
CG477_RS13215	COG2826	transposase and inactivated derivatives, IS30 family
CG477_RS13230	COG0534	Mate efflux family protein
CG477_RS13260	COG3023	N-Acetylmuramoyl-L-alanine amidase
CG477_RS13270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_RS13280	COG5002	protein histidine kinase activity
CG477_RS13285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_RS13290	COG0010	Belongs to the arginase family
CG477_RS13295	COG1228	amidohydrolase
CG477_RS13300	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CG477_RS13305	COG2986	histidine ammonia-lyase
CG477_RS13325	COG4846	Membrane protein involved in cytochrome C biogenesis
CG477_RS13330	COG0785	Cytochrome C biogenesis protein
CG477_RS13345	COG0583	DNA-binding transcription factor activity
CG477_RS13350	COG1380	Effector of murein hydrolase LrgA
CG477_RS13355	COG1346	cytolysis
CG477_RS13360	COG4187	Peptidase family M20/M25/M40
CG477_RS13370	COG0833	amino acid
CG477_RS13380	COG0730	response to heat
CG477_RS13390	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG477_RS13390	COG3409	Peptidoglycan-binding domain 1 protein
CG477_RS13405	COG1132	(ABC) transporter
CG477_RS13410	COG1132	(ABC) transporter
CG477_RS13415	COG3763	UPF0154 protein
CG477_RS13430	COG3639	organic phosphonate transmembrane transporter activity
CG477_RS13435	COG3639	organic phosphonate transmembrane transporter activity
CG477_RS13450	COG0737	Belongs to the 5'-nucleotidase family
CG477_RS13455	COG4224	UPF0291 protein
CG477_RS13460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG477_RS13465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CG477_RS13480	COG1695	Transcriptional regulator
CG477_RS13515	COG3328	transposase activity
CG477_RS13520	COG3328	transposase activity
CG477_RS13525	COG3328	transposase activity
CG477_RS13540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG477_RS13565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG477_RS13585	COG0730	response to heat
CG477_RS13640	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG477_RS13710	COG3723	Recombinational DNA repair protein, rece pathway
CG477_RS13755	COG0582	viral genome integration into host DNA
CG477_RS13760	COG0174	glutamine synthetase
CG477_RS13765	COG0789	Transcriptional regulator
CG477_RS13770	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CG477_RS13775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG477_RS13780	COG2860	membrane
CG477_RS13785	COG0464	growth
CG477_RS13800	COG1923	regulation of RNA biosynthetic process
CG477_RS13805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CG477_RS13815	COG1388	LysM domain
CG477_RS13815	COG3584	3D domain protein
CG477_RS13820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG477_RS13820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG477_RS13820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_RS13825	COG1105	Belongs to the carbohydrate kinase PfkB family
CG477_RS13830	COG1349	DNA-binding transcription factor activity
CG477_RS13835	COG2322	membrane
CG477_RS13860	COG2116	formate transmembrane transporter activity
CG477_RS13870	COG1937	Protein conserved in bacteria
CG477_RS13875	COG2819	hydrolase of the alpha beta superfamily
CG477_RS13880	COG1120	ATPase activity
CG477_RS13885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_RS13890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_RS13895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG477_RS13900	COG2706	6-phosphogluconolactonase activity
CG477_RS13905	COG2826	transposase and inactivated derivatives, IS30 family
CG477_RS13910	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG477_RS13920	COG0346	lactoylglutathione lyase activity
CG477_RS13935	COG1113	amino acid transport
CG477_RS13960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CG477_RS13965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CG477_RS13975	COG4550	Control of competence regulator ComK, YlbF/YmcA
CG477_RS13980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG477_RS13985	COG1013	pyruvate-flavodoxin oxidoreductase activity
CG477_RS13990	COG0674	pyruvate-flavodoxin oxidoreductase activity
CG477_RS13990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CG477_RS14000	COG2359	stage V sporulation protein S
CG477_RS14005	COG1692	metallophosphoesterase
CG477_RS14010	COG1418	mRNA catabolic process
CG477_RS14015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CG477_RS14020	COG1546	Belongs to the CinA family
CG477_RS14020	COG1058	Belongs to the CinA family
CG477_RS14025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG477_RS14030	COG1426	Protein conserved in bacteria
CG477_RS14045	COG0300	oxidoreductase activity
CG477_RS14050	COG0612	Peptidase, M16
CG477_RS14055	COG0612	Peptidase, M16
CG477_RS14060	COG1079	Belongs to the binding-protein-dependent transport system permease family
CG477_RS14065	COG4603	Belongs to the binding-protein-dependent transport system permease family
CG477_RS14070	COG3845	ABC transporter
CG477_RS14075	COG1744	ABC transporter substrate-binding protein PnrA-like
CG477_RS14080	COG2188	Transcriptional regulator
CG477_RS14100	COG0740	serine-type endopeptidase activity
CG477_RS14125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG477_RS14140	COG0527	aspartate kinase activity
CG477_RS14145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CG477_RS14150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG477_RS14155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG477_RS14160	COG1873	PFAM PRC-barrel domain
CG477_RS14165	COG0612	Peptidase, M16
CG477_RS14170	COG0726	polysaccharide deacetylase
CG477_RS14175	COG1185	polyribonucleotide nucleotidyltransferase activity
CG477_RS14185	COG0196	riboflavin kinase activity
CG477_RS14190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CG477_RS14195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CG477_RS14200	COG1550	Protein conserved in bacteria
CG477_RS14205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CG477_RS14210	COG1358	cellular component organization or biogenesis
CG477_RS14215	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CG477_RS14220	COG0195	Participates in both transcription termination and antitermination
CG477_RS14225	COG0779	Required for maturation of 30S ribosomal subunits
CG477_RS14235	COG0442	prolyl-tRNA aminoacylation
CG477_RS14240	COG0750	zinc metalloprotease
CG477_RS14250	COG4589	Belongs to the CDS family
CG477_RS14260	COG0233	cytoplasmic translational termination
CG477_RS14265	COG0528	UMP kinase activity
CG477_RS14270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CG477_RS14275	COG0052	Belongs to the universal ribosomal protein uS2 family
CG477_RS14280	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CG477_RS14285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CG477_RS14290	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CG477_RS14295	COG4974	Belongs to the 'phage' integrase family
CG477_RS14300	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CG477_RS14305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG477_RS14310	COG0758	DNA mediated transformation
CG477_RS14315	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CG477_RS14320	COG0045	succinate-CoA ligase (ADP-forming) activity
CG477_RS14325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG477_RS14340	COG0335	large ribosomal subunit rRNA binding
CG477_RS14345	COG0336	Belongs to the RNA methyltransferase TrmD family
CG477_RS14350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CG477_RS14355	COG1837	Belongs to the UPF0109 family
CG477_RS14360	COG0228	four-way junction DNA binding
CG477_RS14365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CG477_RS14370	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CG477_RS14375	COG0552	protein localization to endoplasmic reticulum
CG477_RS14380	COG1196	nuclear chromosome segregation
CG477_RS14385	COG0571	ribonuclease III activity
CG477_RS14390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG477_RS14395	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS14400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CG477_RS14405	COG0416	fatty acid biosynthetic process
CG477_RS14410	COG2050	protein possibly involved in aromatic compounds catabolism
CG477_RS14410	COG1349	DNA-binding transcription factor activity
CG477_RS14415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CG477_RS14420	COG1461	Dihydroxyacetone kinase
CG477_RS14425	COG1302	Protein conserved in bacteria
CG477_RS14430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CG477_RS14440	COG1564	THIamine pyrophosphokinase
CG477_RS14445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CG477_RS14450	COG1162	GTPase activity
CG477_RS14455	COG2815	serine threonine protein kinase
CG477_RS14455	COG0515	serine threonine protein kinase
CG477_RS14460	COG0631	protein serine/threonine phosphatase activity
CG477_RS14465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CG477_RS14470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CG477_RS14470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG477_RS14475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG477_RS14480	COG0242	peptide deformylase activity
CG477_RS14485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CG477_RS14490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG477_RS14495	COG1758	RNA polymerase activity
CG477_RS14510	COG1561	YicC-like family, N-terminal region
CG477_RS14515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG477_RS14540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CG477_RS14545	COG0284	orotidine-5'-phosphate decarboxylase activity
CG477_RS14550	COG0167	dihydroorotate dehydrogenase activity
CG477_RS14555	COG0543	2 iron, 2 sulfur cluster binding
CG477_RS14560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CG477_RS14570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CG477_RS14575	COG0540	Belongs to the ATCase OTCase family
CG477_RS14585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CG477_RS14595	COG0564	pseudouridine synthase activity
CG477_RS14600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CG477_RS14610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CG477_RS14615	COG3599	regulation of cell shape
CG477_RS14620	COG2302	S4 RNA-binding domain
CG477_RS14625	COG0762	integral membrane protein
CG477_RS14630	COG1799	cell septum assembly
CG477_RS14635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CG477_RS14645	COG1873	PFAM PRC-barrel domain
CG477_RS14650	COG1191	sigma factor activity
CG477_RS14655	COG1191	sigma factor activity
CG477_RS14665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CG477_RS14670	COG0849	cell division
CG477_RS14675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CG477_RS14685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG477_RS14690	COG0772	Belongs to the SEDS family
CG477_RS14695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CG477_RS14700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG477_RS14705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CG477_RS14710	COG0768	penicillin binding
CG477_RS14715	COG0768	penicillin binding
CG477_RS14720	COG4839	cell division protein FtsL
CG477_RS14725	COG0275	rRNA processing
CG477_RS14730	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CG477_RS14735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CG477_RS14740	COG0454	-acetyltransferase
CG477_RS14750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CG477_RS14755	COG1399	metal-binding, possibly nucleic acid-binding protein
CG477_RS14865	COG1802	Transcriptional regulator
CG477_RS14865	COG4626	Terminase
CG477_RS14955	COG0756	dUTP diphosphatase activity
CG477_RS14985	COG3723	Recombinational DNA repair protein, rece pathway
CG477_RS14995	COG5377	YqaJ viral recombinase family
CG477_RS15035	COG0582	viral genome integration into host DNA
CG477_RS15040	COG1323	Belongs to the UPF0348 family
CG477_RS15045	COG3480	Lon protease (S16) C-terminal proteolytic domain
CG477_RS15050	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG477_RS15055	COG3314	Sporulation integral membrane protein YlbJ
CG477_RS15060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CG477_RS15065	COG0742	ribosomal rna small subunit methyltransferase
CG477_RS15075	COG4471	UPF0298 protein
CG477_RS15080	COG3679	Belongs to the UPF0342 family
CG477_RS15085	COG0406	alpha-ribazole phosphatase activity
CG477_RS15100	COG2340	Cysteine-rich secretory protein family
CG477_RS15110	COG3336	cytochrome c oxidase
CG477_RS15135	COG0109	protoheme IX farnesyltransferase activity
CG477_RS15140	COG1612	heme a metabolic process
CG477_RS15145	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CG477_RS15155	COG0772	Belongs to the SEDS family
CG477_RS15160	COG4838	Belongs to the UPF0358 family
CG477_RS15165	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CG477_RS15170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CG477_RS15180	COG4896	Protein conserved in bacteria
CG477_RS15195	COG1217	gtp-binding protein TYPA
CG477_RS15205	COG0483	inositol monophosphate 1-phosphatase activity
CG477_RS15215	COG4493	Belongs to the UPF0637 family
CG477_RS15220	COG4476	Belongs to the UPF0223 family
CG477_RS15225	COG1982	Orn Lys Arg decarboxylase major
CG477_RS15265	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG477_RS15275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG477_RS15290	COG0561	phosphatase activity
CG477_RS15300	COG5503	Protein of unknown function (DUF1447)
CG477_RS15305	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG477_RS15310	COG0569	domain protein
CG477_RS15320	COG1473	amidohydrolase
CG477_RS15325	COG2171	N-acyltransferase activity
CG477_RS15330	COG0583	DNA-binding transcription factor activity
CG477_RS15335	COG0517	IMP dehydrogenase activity
CG477_RS15345	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CG477_RS15365	COG4703	Protein of unknown function (DUF1797)
CG477_RS15380	COG2200	EAL domain
CG477_RS15385	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS15390	COG1408	metallophosphoesterase
CG477_RS15400	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CG477_RS15440	COG2814	Major facilitator Superfamily
CG477_RS15445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CG477_RS15455	COG3209	COG3209 Rhs family protein
CG477_RS15465	COG2205	protein histidine kinase activity
CG477_RS15475	COG0436	Aminotransferase
CG477_RS15480	COG1609	Transcriptional regulator
CG477_RS15485	COG3833	ABC-type maltose transport systems, permease component
CG477_RS15490	COG1175	transmembrane transport
CG477_RS15495	COG2182	Extracellular solute-binding protein
CG477_RS15515	COG0366	Alpha amylase catalytic
CG477_RS15520	COG3842	ATPase activity
CG477_RS15550	COG0183	Belongs to the thiolase family
CG477_RS15580	COG1695	Transcriptional regulator
CG477_RS15585	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS15595	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CG477_RS15600	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CG477_RS15605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CG477_RS15610	COG0436	Aminotransferase
CG477_RS15615	COG1850	ribulose-bisphosphate carboxylase activity
CG477_RS15620	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CG477_RS15625	COG0235	Class ii aldolase
CG477_RS15630	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CG477_RS15645	COG2084	Dehydrogenase
CG477_RS15655	COG2199	diguanylate cyclase activity
CG477_RS15660	COG0778	Nitroreductase
CG477_RS15685	COG2190	(PTS) system
CG477_RS15685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG477_RS15685	COG1263	PTS System
CG477_RS15690	COG3711	transcriptional antiterminator
CG477_RS15700	COG2188	Transcriptional regulator
CG477_RS15705	COG0363	glucosamine-6-phosphate deaminase activity
CG477_RS15720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CG477_RS15725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CG477_RS15735	COG1547	Domain of unknown function (DUF309)
CG477_RS15745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CG477_RS15750	COG4086	secreted protein
CG477_RS15755	COG0561	phosphatase activity
CG477_RS15760	COG0697	spore germination
CG477_RS15775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG477_RS15800	COG0733	neurotransmitter:sodium symporter activity
CG477_RS15810	COG2172	sigma factor antagonist activity
CG477_RS15820	COG1686	Belongs to the peptidase S11 family
CG477_RS15830	COG1725	Transcriptional regulator
CG477_RS15835	COG1131	(ABC) transporter
CG477_RS15860	COG1846	Transcriptional regulator
CG477_RS15875	COG0598	Magnesium transport protein CorA
CG477_RS15905	COG4974	Belongs to the 'phage' integrase family
CG477_RS15915	COG0735	belongs to the Fur family
CG477_RS15920	COG1300	Membrane
CG477_RS15940	COG0667	Aldo Keto reductase
CG477_RS15945	COG0656	L-ascorbic acid biosynthetic process
CG477_RS15950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CG477_RS15950	COG0456	acetyltransferase
CG477_RS15960	COG4085	toxin activity
CG477_RS15960	COG1525	nuclease
CG477_RS15960	COG0737	Belongs to the 5'-nucleotidase family
CG477_RS15970	COG0596	Alpha beta hydrolase
CG477_RS15975	COG2056	Na+-H+ antiporter family
CG477_RS15980	COG1609	Transcriptional regulator
CG477_RS15985	COG0456	acetyltransferase
CG477_RS15990	COG1073	alpha beta
CG477_RS16005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG477_RS16005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG477_RS16010	COG0307	riboflavin synthase, alpha
CG477_RS16015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG477_RS16015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG477_RS16030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CG477_RS16035	COG4106	trans-aconitate 2-methyltransferase activity
CG477_RS16040	COG0596	Alpha beta hydrolase
CG477_RS16045	COG0156	8-amino-7-oxononanoate synthase activity
CG477_RS16055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG477_RS16065	COG1757	Na H antiporter
CG477_RS16070	COG0737	Belongs to the 5'-nucleotidase family
CG477_RS16095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CG477_RS16105	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CG477_RS16115	COG0300	oxidoreductase activity
CG477_RS16120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG477_RS16125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG477_RS16130	COG1760	l-serine dehydratase
CG477_RS16135	COG1760	l-serine dehydratase
CG477_RS16145	COG1234	tRNA 3'-trailer cleavage
CG477_RS16165	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG477_RS16170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG477_RS16185	COG1376	ErfK ybiS ycfS ynhG family protein
CG477_RS16190	COG4129	membrane
CG477_RS16195	COG1126	abc transporter atp-binding protein
CG477_RS16200	COG0765	amino acid transport
CG477_RS16205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG477_RS16220	COG2816	NAD+ diphosphatase activity
CG477_RS16225	COG0772	Belongs to the SEDS family
CG477_RS16235	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG477_RS16240	COG0022	dehydrogenase e1 component
CG477_RS16245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG477_RS16250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG477_RS16255	COG3426	butyrate kinase activity
CG477_RS16265	COG0280	phosphate acetyltransferase
CG477_RS16275	COG3290	protein histidine kinase activity
CG477_RS16275	COG3829	transcription factor binding
CG477_RS16285	COG0584	glycerophosphoryl diester phosphodiesterase
CG477_RS16290	COG3093	addiction module antidote protein HigA
CG477_RS16295	COG0745	RESPONSE REGULATOR receiver
CG477_RS16305	COG0750	zinc metalloprotease
CG477_RS16310	COG0497	DNA recombination
CG477_RS16320	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CG477_RS16325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CG477_RS16335	COG1722	exodeoxyribonuclease VII activity
CG477_RS16340	COG1570	exodeoxyribonuclease VII activity
CG477_RS16345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CG477_RS16350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG477_RS16355	COG1302	Protein conserved in bacteria
CG477_RS16360	COG0439	Biotin carboxylase
CG477_RS16365	COG0511	ligase activity, forming carbon-carbon bonds
CG477_RS16410	COG3854	ATPases associated with a variety of cellular activities
CG477_RS16430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CG477_RS16435	COG0006	proline dipeptidase activity
CG477_RS16440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CG477_RS16450	COG3872	metal-dependent enzyme
CG477_RS16460	COG1321	iron dependent repressor
CG477_RS16475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG477_RS16485	COG1609	Transcriptional regulator
CG477_RS16495	COG2076	Multidrug Resistance protein
CG477_RS16500	COG2076	Multidrug Resistance protein
CG477_RS16520	COG1131	(ABC) transporter
CG477_RS16525	COG1725	Transcriptional regulator
CG477_RS16540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG477_RS16545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG477_RS16550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CG477_RS16555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG477_RS16585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CG477_RS16610	COG1459	type II secretion system
CG477_RS16635	COG4824	toxin secretion phage lysis holin
CG477_RS16720	COG3728	DNA packaging
CG477_RS16730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG477_RS16795	COG1484	DNA-dependent DNA replication
CG477_RS16810	COG3723	Recombinational DNA repair protein, rece pathway
CG477_RS16815	COG5377	YqaJ viral recombinase family
CG477_RS16840	COG1396	sequence-specific DNA binding
CG477_RS16855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CG477_RS16890	COG1078	dGTPase activity
CG477_RS16910	COG0646	methionine synthase
CG477_RS16910	COG1410	methionine synthase
CG477_RS16915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CG477_RS16915	COG0646	methionine synthase
CG477_RS16920	COG0626	cystathionine gamma-synthase activity
CG477_RS16925	COG0626	cystathionine gamma-synthase activity
CG477_RS16945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG477_RS16955	COG1940	carbohydrate kinase activity
CG477_RS16960	COG4483	Protein conserved in bacteria
CG477_RS16965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CG477_RS16970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG477_RS16975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CG477_RS16980	COG0704	Plays a role in the regulation of phosphate uptake
CG477_RS16990	COG0581	inorganic phosphate transmembrane transporter activity
CG477_RS16995	COG0573	inorganic phosphate transmembrane transporter activity
CG477_RS17000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG477_RS17005	COG0768	penicillin binding
CG477_RS17010	COG0477	Major facilitator Superfamily
CG477_RS17015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG477_RS17035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CG477_RS17040	COG0735	belongs to the Fur family
CG477_RS17045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG477_RS17050	COG1121	(ABC) transporter
CG477_RS17055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_RS17065	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CG477_RS17080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CG477_RS17085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CG477_RS17090	COG2384	SAM-dependent methyltransferase
CG477_RS17100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CG477_RS17105	COG0358	DNA primase activity
CG477_RS17110	COG1671	Belongs to the UPF0178 family
CG477_RS17115	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CG477_RS17120	COG0517	IMP dehydrogenase activity
CG477_RS17125	COG1381	Involved in DNA repair and RecF pathway recombination
CG477_RS17135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CG477_RS17145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CG477_RS17150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CG477_RS17155	COG1480	7TM receptor with intracellular HD hydrolase
CG477_RS17160	COG1702	phosphate starvation-inducible protein PhoH
CG477_RS17175	COG1610	YqeY-like protein
CG477_RS17180	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CG477_RS17185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG477_RS17190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CG477_RS17195	COG2264	protein methyltransferase activity
CG477_RS17200	COG0484	heat shock protein binding
CG477_RS17205	COG0443	Heat shock 70 kDa protein
CG477_RS17210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CG477_RS17215	COG1420	regulation of RNA biosynthetic process
CG477_RS17220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG477_RS17225	COG1733	regulation of RNA biosynthetic process
CG477_RS17230	COG0693	protein deglycase activity
CG477_RS17235	COG0481	GTPase activity
CG477_RS17245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CG477_RS17250	COG0268	Binds directly to 16S ribosomal RNA
CG477_RS17255	COG1466	dna polymerase III delta subunit
CG477_RS17265	COG2333	competence protein COMEC
CG477_RS17265	COG0658	competence protein
CG477_RS17270	COG2131	deaminase
CG477_RS17275	COG1596	polysaccharide export
CG477_RS17275	COG1555	photosystem II stabilization
CG477_RS17280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG477_RS17285	COG2226	methyltransferase
CG477_RS17290	COG0799	negative regulation of ribosome biogenesis
CG477_RS17295	COG1713	HD superfamily hydrolase involved in NAD metabolism
CG477_RS17300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CG477_RS17305	COG1534	Rna-binding protein
CG477_RS17310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CG477_RS17315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CG477_RS17320	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CG477_RS17330	COG0688	phosphatidylethanolamine metabolic process
CG477_RS17345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG477_RS17350	COG2357	RelA SpoT domain protein
CG477_RS17355	COG1785	Belongs to the alkaline phosphatase family
CG477_RS17360	COG0456	acetyltransferase
CG477_RS17365	COG2267	carboxylic ester hydrolase activity
CG477_RS17390	COG3186	Phenylalanine-4-hydroxylase
CG477_RS17395	COG2154	pterin-4-alpha-carbinolamine dehydratase
CG477_RS17400	COG2514	catechol 2,3-dioxygenase activity
CG477_RS17405	COG2259	Doxx family
CG477_RS17420	COG1609	Transcriptional regulator
CG477_RS17435	COG0626	cystathionine gamma-synthase activity
CG477_RS17440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG477_RS17445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CG477_RS17450	COG2226	methyltransferase
CG477_RS17465	COG0768	penicillin binding
CG477_RS17475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CG477_RS17480	COG0572	uridine kinase
CG477_RS17485	COG0826	peptidase U32
CG477_RS17490	COG0826	peptidase U32
CG477_RS17495	COG4122	O-methyltransferase activity
CG477_RS17500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CG477_RS17510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CG477_RS17515	COG4472	Bacterial protein of unknown function (DUF965)
CG477_RS17520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG477_RS17525	COG0628	permease
CG477_RS17545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CG477_RS17555	COG0482	sulfurtransferase activity
CG477_RS17560	COG1104	cysteine desulfurase activity
CG477_RS17565	COG1959	2 iron, 2 sulfur cluster binding
CG477_RS17570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CG477_RS17590	COG2207	Transcriptional regulator
CG477_RS17600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CG477_RS17605	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CG477_RS17610	COG0124	histidyl-tRNA synthetase
CG477_RS17630	COG1490	D-aminoacyl-tRNA deacylase activity
CG477_RS17635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG477_RS17640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG477_RS17645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CG477_RS17645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CG477_RS17650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG477_RS17655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG477_RS17655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG477_RS17665	COG2244	polysaccharide biosynthetic process
CG477_RS17690	COG1862	Preprotein translocase
CG477_RS17695	COG0343	queuine tRNA-ribosyltransferase activity
CG477_RS17700	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CG477_RS17710	COG2255	four-way junction helicase activity
CG477_RS17715	COG0632	four-way junction helicase activity
CG477_RS17720	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CG477_RS17740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CG477_RS17745	COG0157	Belongs to the NadC ModD family
CG477_RS17750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CG477_RS17755	COG1104	cysteine desulfurase activity
CG477_RS17760	COG1827	regulation of RNA biosynthetic process
CG477_RS17765	COG2258	MOSC domain
CG477_RS17770	COG0077	Prephenate dehydratase
CG477_RS17775	COG0577	efflux transmembrane transporter activity
CG477_RS17780	COG0577	efflux transmembrane transporter activity
CG477_RS17785	COG1136	(ABC) transporter
CG477_RS17790	COG5002	protein histidine kinase activity
CG477_RS17795	COG0745	RESPONSE REGULATOR receiver
CG477_RS17805	COG3290	protein histidine kinase activity
CG477_RS17810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CG477_RS17815	COG2868	ribosomal protein
CG477_RS17820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CG477_RS17825	COG1530	ribonuclease E activity
CG477_RS17830	COG1994	Peptidase M50
CG477_RS17835	COG0739	heme binding
CG477_RS17840	COG2894	cell division
CG477_RS17845	COG0850	regulation of cytokinetic process
CG477_RS17855	COG1792	Involved in formation and maintenance of cell shape
CG477_RS17860	COG1077	Cell shape determining protein MreB Mrl
CG477_RS17880	COG0424	maF-like protein
CG477_RS17890	COG0285	dihydrofolate synthase activity
CG477_RS17915	COG1388	LysM domain
CG477_RS17915	COG1388	LysM domain
CG477_RS17920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG477_RS17925	COG0113	porphobilinogen synthase activity
CG477_RS17930	COG1587	Uroporphyrinogen-III synthase
CG477_RS17935	COG0181	hydroxymethylbilane synthase activity
CG477_RS17940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG477_RS17945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CG477_RS17950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CG477_RS17960	COG1067	ATP-dependent peptidase activity
CG477_RS17960	COG0470	DNA polymerase III
CG477_RS17965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CG477_RS17970	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG477_RS17995	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS17995	COG3321	synthase
CG477_RS17995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG477_RS17995	COG4221	oxidoreductase activity
CG477_RS18010	COG1033	growth of symbiont in host cell
CG477_RS18010	COG2409	Drug exporters of the RND superfamily
CG477_RS18020	COG1309	transcriptional regulator
CG477_RS18080	COG0622	Phosphoesterase
CG477_RS18090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CG477_RS18095	COG5401	PFAM Sporulation and spore germination
CG477_RS18105	COG2197	response regulator
CG477_RS18115	COG1959	2 iron, 2 sulfur cluster binding
CG477_RS18120	COG1668	transmembrane transport
CG477_RS18125	COG4152	abc transporter atp-binding protein
CG477_RS18130	COG1360	Flagellar Motor Protein
CG477_RS18135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG477_RS18145	COG1876	peptidase activity
CG477_RS18155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CG477_RS18160	COG1053	succinate dehydrogenase
CG477_RS18165	COG2009	succinate dehydrogenase
CG477_RS18170	COG1719	4-vinyl reductase, 4VR
CG477_RS18185	COG3118	belongs to the thioredoxin family
CG477_RS18190	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CG477_RS18195	COG2086	electron transfer activity
CG477_RS18200	COG1024	Enoyl-CoA hydratase
CG477_RS18205	COG1309	transcriptional regulator
CG477_RS18210	COG0318	PFAM AMP-dependent synthetase and ligase
CG477_RS18220	COG2318	DinB family
CG477_RS18235	COG1131	(ABC) transporter
CG477_RS18240	COG2205	protein histidine kinase activity
CG477_RS18245	COG0745	RESPONSE REGULATOR receiver
CG477_RS18255	COG4895	conserved protein (DUF2196)
CG477_RS18260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CG477_RS18265	COG1114	Component of the transport system for branched-chain amino acids
CG477_RS18270	COG1187	pseudouridine synthase activity
CG477_RS18280	COG1193	negative regulation of DNA recombination
CG477_RS18285	COG1796	DNA polymerase
CG477_RS18285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CG477_RS18290	COG1286	toxin biosynthetic process
CG477_RS18295	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CG477_RS18300	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG477_RS18320	COG0017	Asparaginyl-tRNA synthetase
CG477_RS18330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CG477_RS18335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG477_RS18345	COG1418	mRNA catabolic process
CG477_RS18360	COG2814	Major facilitator Superfamily
CG477_RS18365	COG1566	PFAM secretion protein HlyD family protein
CG477_RS18370	COG1309	transcriptional regulator
CG477_RS18375	COG1363	Peptidase, m42
CG477_RS18385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CG477_RS18390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CG477_RS18400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG477_RS18410	COG1484	DNA-dependent DNA replication
CG477_RS18415	COG3611	Membrane attachment protein
CG477_RS18420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CG477_RS18425	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CG477_RS18430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG477_RS18440	COG1971	Probably functions as a manganese efflux pump
CG477_RS18450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG477_RS18450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG477_RS18455	COG5002	protein histidine kinase activity
CG477_RS18460	COG0745	RESPONSE REGULATOR receiver
CG477_RS18470	COG0039	L-malate dehydrogenase activity
CG477_RS18475	COG0538	isocitrate dehydrogenase activity
CG477_RS18480	COG0372	Belongs to the citrate synthase family
CG477_RS18490	COG2707	UPF0756 membrane protein
CG477_RS18500	COG0628	permease
CG477_RS18505	COG3030	protein affecting phage T7 exclusion by the F plasmid
CG477_RS18515	COG0205	6-phosphofructokinase activity
CG477_RS18520	COG0825	malonyl-CoA metabolic process
CG477_RS18525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CG477_RS18530	COG1725	Transcriptional regulator
CG477_RS18535	COG0281	malic enzyme
CG477_RS18540	COG0587	DNA-directed DNA polymerase activity
CG477_RS18555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CG477_RS18570	COG4109	DRTGG domain
CG477_RS18575	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CG477_RS18580	COG0006	proline dipeptidase activity
CG477_RS18605	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_RS18610	COG0589	response to stress
CG477_RS18635	COG0165	Argininosuccinate lyase
CG477_RS18640	COG0137	argininosuccinate synthase activity
CG477_RS18650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_RS18660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG477_RS18665	COG0827	DNA restriction-modification system
CG477_RS18670	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CG477_RS18675	COG3874	Sporulation protein YtfJ
CG477_RS18690	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CG477_RS18695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG477_RS18705	COG0301	tRNA thio-modification
CG477_RS18710	COG1104	cysteine desulfurase activity
CG477_RS18715	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CG477_RS18720	COG0583	DNA-binding transcription factor activity
CG477_RS18725	COG0697	spore germination
CG477_RS18730	COG1309	transcriptional regulator
CG477_RS18735	COG1956	GAF domain-containing protein
CG477_RS18740	COG0626	cystathionine gamma-synthase activity
CG477_RS18750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CG477_RS18785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG477_RS18790	COG0454	-acetyltransferase
CG477_RS18795	COG0517	IMP dehydrogenase activity
CG477_RS18800	COG0123	including yeast histone deacetylase and acetoin utilization protein
CG477_RS18805	COG1970	mechanosensitive ion channel activity
CG477_RS18815	COG1609	Transcriptional regulator
CG477_RS18825	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG477_RS18825	COG1605	Chorismate mutase
CG477_RS18830	COG3118	belongs to the thioredoxin family
CG477_RS18840	COG2309	aminopeptidase activity
CG477_RS18855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CG477_RS18865	COG1674	ftsk spoiiie
CG477_RS18875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG477_RS18880	COG4848	Belongs to the UPF0354 family
CG477_RS18885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG477_RS18890	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CG477_RS18910	COG1363	Peptidase, m42
CG477_RS18920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG477_RS18925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CG477_RS18935	COG0510	thiamine kinase activity
CG477_RS18940	COG1523	belongs to the glycosyl hydrolase 13 family
CG477_RS18950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG477_RS18955	COG1349	DNA-binding transcription factor activity
CG477_RS18960	COG1187	pseudouridine synthase activity
CG477_RS18965	COG2244	polysaccharide biosynthetic process
CG477_RS18970	COG2081	HI0933 family
CG477_RS18975	COG2814	Major facilitator Superfamily
CG477_RS18985	COG3832	glyoxalase III activity
CG477_RS19005	COG1329	Transcriptional regulator
CG477_RS19015	COG2223	nitrite transmembrane transporter activity
CG477_RS19025	COG0314	molybdopterin synthase activity
CG477_RS19030	COG1763	Mo-molybdopterin cofactor biosynthetic process
CG477_RS19035	COG0303	'Molybdopterin
CG477_RS19040	COG0315	cyclic pyranopterin monophosphate synthase activity
CG477_RS19045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG477_RS19050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CG477_RS19055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG477_RS19060	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CG477_RS19065	COG1140	nitrate reductase beta subunit
CG477_RS19070	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CG477_RS19075	COG2181	nitrate reductase activity
CG477_RS19090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG477_RS19100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CG477_RS19140	COG0495	leucyl-tRNA aminoacylation
CG477_RS19145	COG2814	Major facilitator Superfamily
CG477_RS19155	COG1136	(ABC) transporter
CG477_RS19160	COG0346	lactoylglutathione lyase activity
CG477_RS19175	COG1242	4 iron, 4 sulfur cluster binding
CG477_RS19180	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CG477_RS19185	COG1121	(ABC) transporter
CG477_RS19195	COG1794	racemase activity, acting on amino acids and derivatives
CG477_RS19205	COG2378	regulation of single-species biofilm formation
CG477_RS19215	COG2267	carboxylic ester hydrolase activity
CG477_RS19220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CG477_RS19230	COG0746	molybdenum cofactor guanylyltransferase activity
CG477_RS19255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CG477_RS19265	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CG477_RS19315	COG0800	Aldolase
CG477_RS19320	COG2610	gluconate transmembrane transporter activity
CG477_RS19325	COG1312	Catalyzes the dehydration of D-mannonate
CG477_RS19330	COG0246	Mannitol dehydrogenase
CG477_RS19335	COG1414	Transcriptional regulator
CG477_RS19340	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG477_RS19340	COG3409	Peptidoglycan-binding domain 1 protein
CG477_RS19350	COG1368	sulfuric ester hydrolase activity
CG477_RS19365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG477_RS19370	COG1116	anion transmembrane transporter activity
CG477_RS19375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG477_RS19390	COG0494	nUDIX hydrolase
CG477_RS19400	COG1854	S-ribosylhomocysteine lyase activity
CG477_RS19405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CG477_RS19410	COG0288	reversible hydration of carbon dioxide
CG477_RS19415	COG1271	oxidase subunit
CG477_RS19420	COG1294	oxidase, subunit
CG477_RS19450	COG1842	Phage shock protein A
CG477_RS19490	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CG477_RS19495	COG1597	lipid kinase activity
CG477_RS19500	COG1136	(ABC) transporter
CG477_RS19510	COG0745	RESPONSE REGULATOR receiver
CG477_RS19515	COG2205	protein histidine kinase activity
CG477_RS19520	COG0577	efflux transmembrane transporter activity
CG477_RS19525	COG1136	(ABC) transporter
CG477_RS19530	COG0577	efflux transmembrane transporter activity
CG477_RS19545	COG4948	Mandelate Racemase Muconate Lactonizing
CG477_RS19550	COG0318	PFAM AMP-dependent synthetase and ligase
CG477_RS19555	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CG477_RS19560	COG0596	Alpha beta hydrolase
CG477_RS19565	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CG477_RS19570	COG1169	isochorismate synthase
CG477_RS19575	COG1575	Belongs to the MenA family. Type 1 subfamily
CG477_RS19580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CG477_RS19600	COG0058	SHG alpha-glucan phosphorylase activity
CG477_RS19605	COG0297	glycogen (starch) synthase activity
CG477_RS19610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG477_RS19615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG477_RS19620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CG477_RS19725	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG477_RS19760	COG1285	pathogenesis
CG477_RS19765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG477_RS19775	COG0166	Belongs to the GPI family
CG477_RS19785	COG2155	Conserved Protein
CG477_RS19790	COG1098	S1 RNA binding domain
CG477_RS19795	COG0436	Aminotransferase
CG477_RS19800	COG1522	sequence-specific DNA binding
CG477_RS19805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG477_RS19810	COG2267	carboxylic ester hydrolase activity
CG477_RS19820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CG477_RS19825	COG2032	superoxide dismutase activity
CG477_RS19835	COG5018	Exonuclease
CG477_RS19840	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG477_RS19865	COG2050	protein possibly involved in aromatic compounds catabolism
CG477_RS19875	COG1268	BioY protein
CG477_RS19880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG477_RS19885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG477_RS19895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CG477_RS19905	COG3584	3D domain protein
CG477_RS19925	COG1252	NADH dehydrogenase
CG477_RS19930	COG0492	ferredoxin-NADP+ reductase activity
CG477_RS19945	COG1683	Conserved Protein
CG477_RS19980	COG1131	(ABC) transporter
CG477_RS20005	COG0316	Belongs to the HesB IscA family
CG477_RS20010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CG477_RS20015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG477_RS20025	COG1252	NADH dehydrogenase
CG477_RS20030	COG2824	Alkylphosphonate utilization operon protein PhnA
CG477_RS20040	COG3655	Transcriptional regulator
CG477_RS20055	COG4837	Protein of unknown function (DUF1462)
CG477_RS20060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CG477_RS20065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG477_RS20070	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CG477_RS20075	COG0647	UMP catabolic process
CG477_RS20085	COG2445	Protein of unknown function DUF86
CG477_RS20090	COG1494	fructose-1,6-bisphosphatase
CG477_RS20100	COG4470	Protein conserved in bacteria
CG477_RS20110	COG0789	Transcriptional regulator
CG477_RS20115	COG4377	Putative membrane peptidase family (DUF2324)
CG477_RS20130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CG477_RS20135	COG0739	heme binding
CG477_RS20145	COG3377	Domain of unknown function (DUF1805)
CG477_RS20150	COG0737	Belongs to the 5'-nucleotidase family
CG477_RS20170	COG0719	Fe-S assembly protein
CG477_RS20175	COG0822	iron-sulfur transferase activity
CG477_RS20180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CG477_RS20185	COG0719	Fe-S assembly protein
CG477_RS20190	COG0396	ATPase activity
CG477_RS20195	COG1464	Belongs to the NlpA lipoprotein family
CG477_RS20200	COG2011	ABC-type metal ion transport system permease component
CG477_RS20220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG477_RS20225	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CG477_RS20230	COG0509	glycine decarboxylation via glycine cleavage system
CG477_RS20235	COG1393	Belongs to the ArsC family
CG477_RS20275	COG1960	acyl-CoA dehydrogenase activity
CG477_RS20280	COG0183	Belongs to the thiolase family
CG477_RS20285	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG477_RS20285	COG1024	Enoyl-CoA hydratase
CG477_RS20295	COG1686	Belongs to the peptidase S11 family
CG477_RS20320	COG0011	TIGRFAM Protein of
CG477_RS20325	COG0840	transmembrane signaling receptor activity
CG477_RS20340	COG0531	amino acid
CG477_RS20345	COG0706	membrane insertase activity
CG477_RS20355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_RS20365	COG0586	Pfam SNARE associated Golgi protein
CG477_RS20375	COG1376	ErfK ybiS ycfS ynhG family protein
CG477_RS20380	COG0745	RESPONSE REGULATOR receiver
CG477_RS20385	COG5002	protein histidine kinase activity
CG477_RS20390	COG0840	transmembrane signaling receptor activity
CG477_RS20395	COG0840	transmembrane signaling receptor activity
CG477_RS20400	COG2151	metal-sulfur cluster biosynthetic enzyme
CG477_RS20405	COG3227	Zinc metalloprotease (Elastase)
CG477_RS20410	COG1741	Belongs to the pirin family
CG477_RS20425	COG0783	Belongs to the Dps family
CG477_RS20430	COG1611	Belongs to the LOG family
CG477_RS20460	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG477_RS20465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG477_RS20470	COG1121	(ABC) transporter
CG477_RS20495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG477_RS20500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG477_RS20505	COG1115	amino acid carrier protein
CG477_RS20510	COG2910	NAD(P)H-binding
CG477_RS20525	COG1252	NADH dehydrogenase
CG477_RS20540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG477_RS20555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG477_RS20560	COG1917	Cupin 2, conserved barrel domain protein
CG477_RS20560	COG4977	sequence-specific DNA binding
CG477_RS20570	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CG477_RS20590	COG0697	spore germination
CG477_RS20605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CG477_RS20610	COG0557	exoribonuclease II activity
CG477_RS20615	COG1647	Serine aminopeptidase, S33
CG477_RS20620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CG477_RS20625	COG1346	cytolysis
CG477_RS20635	COG0148	phosphopyruvate hydratase activity
CG477_RS20640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CG477_RS20645	COG0149	triose-phosphate isomerase activity
CG477_RS20650	COG0126	phosphoglycerate kinase activity
CG477_RS20655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG477_RS20670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CG477_RS20720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG477_RS20735	COG2323	membrane
CG477_RS20750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_RS20755	COG1481	regulation of sporulation
CG477_RS20760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CG477_RS20765	COG1660	Displays ATPase and GTPase activities
CG477_RS20770	COG1051	belongs to the nudix hydrolase family
CG477_RS20780	COG0492	ferredoxin-NADP+ reductase activity
CG477_RS20785	COG0457	Tetratricopeptide repeat
CG477_RS20790	COG0110	maltose O-acetyltransferase activity
CG477_RS20800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CG477_RS20805	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CG477_RS20810	COG1950	PFAM Membrane protein of
CG477_RS20820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CG477_RS20835	COG0789	Transcriptional regulator
CG477_RS20855	COG0583	DNA-binding transcription factor activity
CG477_RS20870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG477_RS20875	COG0793	Belongs to the peptidase S41A family
CG477_RS20875	COG3409	Peptidoglycan-binding domain 1 protein
CG477_RS20880	COG2177	Part of the ABC transporter FtsEX involved in
CG477_RS20885	COG2884	Cell division ATP-binding protein ftsE
CG477_RS20910	COG1278	Cold shock
CG477_RS20915	COG1040	competence protein
CG477_RS20920	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CG477_RS20925	COG1388	LysM domain
CG477_RS20925	COG0791	NLP P60 protein
CG477_RS20930	COG1733	regulation of RNA biosynthetic process
CG477_RS20935	COG1307	EDD domain protein, DegV family
CG477_RS20940	COG1739	Uncharacterized protein family UPF0029
CG477_RS20945	COG1316	TRANSCRIPTIONal
CG477_RS20955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CG477_RS20965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG477_RS20975	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CG477_RS20975	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CG477_RS20990	COG1486	melibiose metabolic process
CG477_RS20995	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG477_RS21010	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG477_RS21015	COG1301	dicarboxylic acid transport
CG477_RS21020	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CG477_RS21025	COG1271	oxidase subunit
CG477_RS21030	COG1294	oxidase, subunit
CG477_RS21035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CG477_RS21040	COG1620	l-lactate permease
CG477_RS21045	COG2389	metal-binding protein
CG477_RS21055	COG1368	sulfuric ester hydrolase activity
CG477_RS21065	COG0791	NLP P60 protein
CG477_RS21065	COG1388	LysM domain
CG477_RS21070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG477_RS21080	COG1215	transferase activity, transferring glycosyl groups
CG477_RS21090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG477_RS21095	COG1388	LysM domain
CG477_RS21095	COG3584	3D domain protein
CG477_RS21110	COG4715	Zinc finger, swim domain protein
CG477_RS21115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG477_RS21155	COG0577	efflux transmembrane transporter activity
CG477_RS21160	COG1136	(ABC) transporter
CG477_RS21195	COG3850	Histidine kinase
CG477_RS21195	COG5002	protein histidine kinase activity
CG477_RS21200	COG0745	RESPONSE REGULATOR receiver
CG477_RS21210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG477_RS21220	COG1215	transferase activity, transferring glycosyl groups
CG477_RS21220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG477_RS21225	COG1134	teichoic acid transport
CG477_RS21230	COG1682	transport, permease protein
CG477_RS21235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG477_RS21240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG477_RS21240	COG0463	Glycosyl transferase, family 2
CG477_RS21245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG477_RS21250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CG477_RS21265	COG1609	Transcriptional regulator
CG477_RS21275	COG0739	heme binding
CG477_RS21290	COG3279	Response regulator of the LytR AlgR family
CG477_RS21295	COG2385	sporulation resulting in formation of a cellular spore
CG477_RS21310	COG4836	Membrane
CG477_RS21315	COG1007	ATP synthesis coupled electron transport
CG477_RS21320	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG477_RS21325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG477_RS21330	COG0713	ATP synthesis coupled electron transport
CG477_RS21335	COG0839	Belongs to the complex I subunit 6 family
CG477_RS21345	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CG477_RS21350	COG0649	NAD binding
CG477_RS21355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG477_RS21360	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG477_RS21365	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG477_RS21370	COG5001	Diguanylate cyclase
CG477_RS21370	COG3300	MHYT domain
CG477_RS21375	COG5001	Diguanylate cyclase
CG477_RS21375	COG3300	MHYT domain
CG477_RS21390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CG477_RS21395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CG477_RS21405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CG477_RS21410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CG477_RS21415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG477_RS21420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CG477_RS21425	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG477_RS21450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CG477_RS21455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CG477_RS21465	COG0698	ribose 5-phosphate isomerase
CG477_RS21490	COG2259	Doxx family
CG477_RS21495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CG477_RS21510	COG0009	L-threonylcarbamoyladenylate synthase
CG477_RS21525	COG2890	protein-(glutamine-N5) methyltransferase activity
CG477_RS21530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CG477_RS21535	COG1435	thymidine kinase activity
CG477_RS21545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CG477_RS21550	COG1494	fructose-1,6-bisphosphatase
CG477_RS21570	COG4821	SIS domain
CG477_RS21575	COG0504	CTP synthase activity
CG477_RS21590	COG1960	acyl-CoA dehydrogenase activity
CG477_RS21595	COG1960	acyl-CoA dehydrogenase activity
CG477_RS21600	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG477_RS21605	COG0183	Belongs to the thiolase family
CG477_RS21610	COG2181	nitrate reductase activity
CG477_RS21610	COG0247	lactate metabolic process
CG477_RS21615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG477_RS21635	COG2197	response regulator
CG477_RS21640	COG4585	Histidine kinase
CG477_RS21645	COG0842	Transport permease protein
CG477_RS21650	COG1131	(ABC) transporter
CG477_RS21655	COG0024	Methionine aminopeptidase
CG477_RS21660	COG2234	aminopeptidase activity
CG477_RS21675	COG4506	Protein conserved in bacteria
CG477_RS21680	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG477_RS21695	COG0010	Belongs to the arginase family
CG477_RS21700	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CG477_RS21705	COG2814	Major facilitator Superfamily
CG477_RS21710	COG0789	Transcriptional regulator
CG477_RS21715	COG0584	glycerophosphoryl diester phosphodiesterase
CG477_RS21720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG477_RS21730	COG1994	Peptidase M50
CG477_RS21740	COG1078	dGTPase activity
CG477_RS21745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG477_RS21750	COG1120	ATPase activity
CG477_RS21755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_RS21760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_RS21765	COG4844	belongs to the
CG477_RS21780	COG0280	phosphate acetyltransferase
CG477_RS21785	COG3253	May function as heme-dependent peroxidase
CG477_RS21795	COG3773	Cell wall hydrolase
CG477_RS21805	COG2363	Small membrane protein
CG477_RS21815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG477_RS21820	COG2233	PERMEase
CG477_RS21825	COG0561	phosphatase activity
CG477_RS21830	COG2814	Major facilitator Superfamily
CG477_RS21835	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CG477_RS21840	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG477_RS21845	COG1131	(ABC) transporter
CG477_RS21850	COG2755	lipolytic protein G-D-S-L family
CG477_RS21855	COG0460	homoserine dehydrogenase
CG477_RS21860	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CG477_RS21865	COG2873	o-acetylhomoserine
CG477_RS21875	COG0351	phosphomethylpyrimidine kinase
CG477_RS21885	COG1966	Carbon starvation protein
CG477_RS21890	COG3279	Response regulator of the LytR AlgR family
CG477_RS21895	COG0477	Major facilitator Superfamily
CG477_RS21905	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CG477_RS21910	COG0438	transferase activity, transferring glycosyl groups
CG477_RS21925	COG0840	transmembrane signaling receptor activity
CG477_RS21940	COG1607	acyl-coa hydrolase
CG477_RS21945	COG1216	Glycosyl transferase, family 2
CG477_RS21960	COG0463	Glycosyl transferase, family 2
CG477_RS21975	COG0463	Glycosyl transferase, family 2
CG477_RS21980	COG0488	(ABC) transporter
CG477_RS21985	COG1309	transcriptional regulator
CG477_RS21990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG477_RS21995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG477_RS21995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG477_RS22000	COG0628	permease
CG477_RS22005	COG1346	cytolysis
CG477_RS22015	COG3279	Response regulator of the LytR AlgR family
CG477_RS22020	COG3275	phosphorelay sensor kinase activity
CG477_RS22025	COG2814	Major facilitator Superfamily
CG477_RS22030	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CG477_RS22035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG477_RS22045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG477_RS22050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_RS22050	COG3711	transcriptional antiterminator
CG477_RS22110	COG0582	viral genome integration into host DNA
CG477_RS22125	COG1132	(ABC) transporter
CG477_RS22135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CG477_RS22145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG477_RS22150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CG477_RS22155	COG4853	Protein conserved in bacteria
CG477_RS22165	COG5002	protein histidine kinase activity
CG477_RS22170	COG0745	RESPONSE REGULATOR receiver
CG477_RS22195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CG477_RS22200	COG0305	Participates in initiation and elongation during chromosome replication
CG477_RS22205	COG0359	binds to the 23S rRNA
CG477_RS22210	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CG477_RS22215	COG4241	membrane
CG477_RS22220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CG477_RS22230	COG0360	Binds together with S18 to 16S ribosomal RNA
CG477_RS22235	COG0012	GTP binding
CG477_RS22240	COG4481	Protein conserved in bacteria
CG477_RS22245	COG0668	transmembrane transport
CG477_RS22255	COG1475	DNA binding
CG477_RS22260	COG1192	Involved in chromosome partitioning
CG477_RS22265	COG1475	DNA binding
CG477_RS22270	COG0357	Ribosomal RNA small subunit methyltransferase G
CG477_RS22275	COG0445	tRNA wobble uridine modification
CG477_RS22280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CG477_RS22285	COG1847	R3H domain protein
CG477_RS22290	COG0706	membrane insertase activity
CG477_RS22295	COG0594	ribonuclease P activity
CG477_RS22300	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CG477_RS22315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CG477_RS22320	COG3209	COG3209 Rhs family protein
CG477_RS22515	COG1476	TRANSCRIPTIONal
CG477_RS22520	COG2197	response regulator
CG477_RS22530	COG1073	alpha beta
CG477_RS22565	COG0457	Tetratricopeptide repeat
CG477_RS22685	COG0741	lytic transglycosylase activity
CG477_RS22685	COG0791	NLP P60 protein
CG477_RS22835	COG1192	Involved in chromosome partitioning
CG477_RS22875	COG0457	Tetratricopeptide repeat
CG477_RS22885	COG4166	transmembrane transport
CG477_RS22920	COG4974	Belongs to the 'phage' integrase family
CG477_RS23000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG477_RS23015	COG0583	DNA-binding transcription factor activity
CG477_RS23035	COG1028	Short-chain dehydrogenase reductase Sdr