locus-tag class description FSZ17_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FSZ17_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FSZ17_RS00015 ENOG410848D S4 domain protein YaaA FSZ17_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FSZ17_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FSZ17_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FSZ17_RS00040 ENOG4105CPI Metal Dependent Phosphohydrolase FSZ17_RS00075 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FSZ17_RS00095 ENOG4105ZMH deoxynucleoside kinase FSZ17_RS00105 ENOG4105VRS hydrolase family 18 FSZ17_RS00110 ENOG4108Z6B deaminase FSZ17_RS00120 ENOG4105C6E dna polymerase iii FSZ17_RS00125 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FSZ17_RS00130 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FSZ17_RS00140 ENOG41067KS pro-sigma K processing FSZ17_RS00175 ENOG4105CXN decarboxylase FSZ17_RS00180 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FSZ17_RS00185 ENOG4105X0R protein from nitrogen regulatory protein P-II FSZ17_RS00190 ENOG4105FA2 dna polymerase iii FSZ17_RS00195 ENOG4105MA4 psp1 domain protein FSZ17_RS00200 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) FSZ17_RS00205 ENOG41060K3 Methyltransferase FSZ17_RS00210 ENOG4105VC4 domain protein FSZ17_RS00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FSZ17_RS00220 ENOG4105KRN Transcriptional regulator, abrb family FSZ17_RS00230 ENOG4105F8V Hydrolase, tatD family FSZ17_RS00235 ENOG41069ER domain protein FSZ17_RS00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FSZ17_RS00245 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FSZ17_RS00250 ENOG4105XFA sporulation peptidase YabG FSZ17_RS00255 ENOG4105W42 Veg protein FSZ17_RS00275 ENOG4105DFT pur operon repressor FSZ17_RS00280 ENOG4105KME endoribonuclease L-psp FSZ17_RS00290 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FSZ17_RS00300 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FSZ17_RS00315 ENOG4108JA2 transcriptioN-repair coupling factor FSZ17_RS00320 ENOG4108M14 stage v sporulation protein t FSZ17_RS00330 ENOG4108IY2 MazG family FSZ17_RS00335 ENOG41082I2 s4 domain protein FSZ17_RS00340 ENOG4105VYY sporulation protein yabp FSZ17_RS00355 ENOG41060GV RNA binding s1 domain protein FSZ17_RS00380 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FSZ17_RS00385 ENOG4108UGV hypoxanthine phosphoribosyltransferase FSZ17_RS00390 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FSZ17_RS00395 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FSZ17_RS00400 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FSZ17_RS00405 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase FSZ17_RS00410 ENOG4105C6T cysteine synthase FSZ17_RS00415 ENOG4105CRQ synthase (Component I) FSZ17_RS00420 ENOG4105DDQ anthranilate synthase FSZ17_RS00425 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FSZ17_RS00430 ENOG4105EEI dihydropteroate synthase FSZ17_RS00435 ENOG4105KRF dihydroneopterin aldolase FSZ17_RS00440 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FSZ17_RS00450 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FSZ17_RS00455 ENOG4105CRK lysyL-tRNA synthetase FSZ17_RS00540 ENOG4108Z0C Uvrb UvrC protein FSZ17_RS00545 ENOG41066A3 ATP guanido phosphotransferase FSZ17_RS00555 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FSZ17_RS00565 ENOG4105CTP PilT protein domain protein FSZ17_RS00570 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FSZ17_RS00575 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FSZ17_RS00580 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FSZ17_RS00585 ENOG4105D7W serine acetyltransferase FSZ17_RS00590 ENOG4105C8N cysteinyl-tRNA synthetase FSZ17_RS00600 ENOG4105C2N RNA methyltransferase TrmH family group 3 FSZ17_RS00605 ENOG4105M0M Tetracycline resistance protein FSZ17_RS00610 ENOG4105QIV RNA polymerase FSZ17_RS00625 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FSZ17_RS00635 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FSZ17_RS00640 ENOG4108VZM 50s ribosomal protein L10 FSZ17_RS00645 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FSZ17_RS00650 ENOG4107Y49 methyltransferase FSZ17_RS00655 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FSZ17_RS00665 ENOG4105XPM ribosomal protein FSZ17_RS00670 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FSZ17_RS00680 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FSZ17_RS00685 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FSZ17_RS00695 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FSZ17_RS00700 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FSZ17_RS00705 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FSZ17_RS00710 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FSZ17_RS00725 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FSZ17_RS00730 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FSZ17_RS00735 ENOG41082SA 50s ribosomal protein l29 FSZ17_RS00740 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FSZ17_RS00755 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FSZ17_RS00765 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FSZ17_RS00770 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FSZ17_RS00775 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FSZ17_RS00780 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FSZ17_RS00785 ENOG4105VPB 50S ribosomal protein L30 FSZ17_RS00790 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FSZ17_RS00795 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FSZ17_RS00800 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FSZ17_RS00805 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FSZ17_RS00810 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FSZ17_RS00820 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FSZ17_RS00830 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FSZ17_RS00835 ENOG4108ZT0 50S ribosomal protein l17 FSZ17_RS00840 ENOG4108JJB ABC transporter FSZ17_RS00845 ENOG4108JJB ABC transporter FSZ17_RS00850 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FSZ17_RS00860 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FSZ17_RS00865 ENOG4108UJD 30S ribosomal protein S9 FSZ17_RS00870 ENOG4105VTR Integrase FSZ17_RS00880 ENOG4108VQT Alpha beta hydrolase fold protein FSZ17_RS00920 ENOG4105D1F ATP-binding protein FSZ17_RS00935 ENOG4108NMV polysaccharide deacetylase FSZ17_RS01010 ENOG4105EMN RNA polymerase sigma factor FSZ17_RS01020 ENOG4105C8B TIGR00159 family FSZ17_RS01025 ENOG4107U5W ybbr family FSZ17_RS01030 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FSZ17_RS01035 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FSZ17_RS01040 ENOG4105CVR type I restriction-modification system FSZ17_RS01050 ENOG4105DZR Type I site-specific deoxyribonuclease FSZ17_RS01135 ENOG4105W1Y Transcriptional regulator FSZ17_RS01145 ENOG4108Z12 YiaAB two helix domain-containing protein FSZ17_RS01165 ENOG4108J2R molybdopterin oxidoreductase FSZ17_RS01170 ENOG4105QAX Iron-sulfur FSZ17_RS01175 ENOG4107YHD transcriptional regulator FSZ17_RS01190 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FSZ17_RS01205 ENOG4105KZX Pterin carbinolamine dehydratase FSZ17_RS01210 ENOG4105MIR Phenylalanine 4-monooxygenase FSZ17_RS01215 ENOG4105C6Y Udp-glucose 6-dehydrogenase FSZ17_RS01240 ENOG4105C3Q Glycosyl transferase, family 2 FSZ17_RS01250 ENOG4105EKT )-iron permease FSZ17_RS01265 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FSZ17_RS01305 ENOG4105SF0 DinB family FSZ17_RS01310 ENOG4108YYS metal-dependent hydrolase (By similarity) FSZ17_RS01340 ENOG4108NGU Transcriptional regulator FSZ17_RS01345 ENOG4105F27 Major Facilitator FSZ17_RS01360 ENOG410904A RNA polymerase FSZ17_RS01375 ENOG4107WA4 MmpL domain-containing protein FSZ17_RS01395 ENOG4105BZ1 (ABC) transporter FSZ17_RS01400 ENOG4105BZ1 (ABC) transporter FSZ17_RS01425 ENOG4105EC3 peptidase S51, dipeptidase E FSZ17_RS01435 ENOG4105C3F Signal peptidase i FSZ17_RS01440 ENOG4108KP7 hydrolase FSZ17_RS01495 ENOG4108HWY Beta-lactamase FSZ17_RS01515 ENOG4107RBI VanW family FSZ17_RS01555 ENOG4105X5K response regulator receiver protein FSZ17_RS01570 ENOG4105DU6 RNA polymerase FSZ17_RS01575 ENOG4108ZRV stage ii sporulation protein p FSZ17_RS01610 ENOG4108WS4 fmn reductase FSZ17_RS01615 ENOG4107V2S Transcriptional regulator FSZ17_RS01625 ENOG4105CHR reductase FSZ17_RS01635 ENOG4105C59 p-type ATPase FSZ17_RS01645 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FSZ17_RS01650 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FSZ17_RS01670 ENOG41088CC tellurite resistance protein tehB FSZ17_RS01680 ENOG4105C75 arginyL-tRNA synthetase FSZ17_RS01700 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FSZ17_RS01710 ENOG4105E2A Dehydrogenase FSZ17_RS01730 ENOG4105EV4 Multidrug resistance protein mdtH FSZ17_RS01735 ENOG4105DUM transcriptional regulator, lysR family FSZ17_RS01740 ENOG4108NGU Transcriptional regulator FSZ17_RS01755 ENOG4105DDN Pentapeptide repeat-containing protein FSZ17_RS01760 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FSZ17_RS01780 ENOG4108V7D UPF0397 protein FSZ17_RS01790 ENOG4105CG3 alpha amylase, catalytic region FSZ17_RS01795 ENOG4105DKQ ROK family FSZ17_RS01800 ENOG4108IJG ABC transporter substrate-binding protein FSZ17_RS01840 ENOG4108ZHR arsR family transcriptional regulator FSZ17_RS01845 ENOG4108SQ9 flavin reductase domain protein, FMN-binding FSZ17_RS01855 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FSZ17_RS01865 ENOG4105CHM Aminotransferase FSZ17_RS01870 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FSZ17_RS01875 ENOG4108RA0 tripartite ATP-independent periplasmic transporter, DctQ component FSZ17_RS01880 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FSZ17_RS01885 ENOG4105DRR Transcriptional regulator, GntR family FSZ17_RS01890 ENOG4105CQB FAD linked oxidase domain protein FSZ17_RS01930 ENOG4105KK4 UPF0060 membrane protein FSZ17_RS01935 ENOG4106YBV Methyl-accepting chemotaxis FSZ17_RS01945 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase FSZ17_RS01950 ENOG4105C98 muts2 protein FSZ17_RS01955 ENOG4105C6X Major Facilitator FSZ17_RS01985 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FSZ17_RS01990 ENOG4108MRH transcriptional regulatory protein FSZ17_RS01995 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FSZ17_RS02000 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FSZ17_RS02005 ENOG4108RA0 tripartite ATP-independent periplasmic transporter, DctQ component FSZ17_RS02010 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FSZ17_RS02020 ENOG4108W8B Beta-lactamase domain protein FSZ17_RS02040 ENOG4105KD7 acetyltransferase FSZ17_RS02075 ENOG4105D5T phosphonate abc transporter FSZ17_RS02085 ENOG4105CGH 5'-nucleotidase FSZ17_RS02225 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FSZ17_RS02245 ENOG4105C0R drug resistance transporter emrb qaca subfamily FSZ17_RS02250 ENOG4108UIN ybak prolyl-trna synthetase associated region FSZ17_RS02260 ENOG4105C8Q Methyl-accepting chemotaxis FSZ17_RS02355 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FSZ17_RS02375 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FSZ17_RS02380 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme FSZ17_RS02385 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FSZ17_RS02395 ENOG4105K64 Glycosyl transferase, family 2 FSZ17_RS02410 ENOG410839P FSZ17_RS02425 ENOG4105C6Y Udp-glucose 6-dehydrogenase FSZ17_RS02435 ENOG4105EYF MMPL domain protein FSZ17_RS02445 ENOG410839T multidrug resistance protein FSZ17_RS02455 ENOG4105BZU Histidine kinase FSZ17_RS02460 ENOG4105WH1 Two component transcriptional regulator luxr family FSZ17_RS02465 ENOG4105CJ1 ABC, transporter FSZ17_RS02485 ENOG4108K2B transcriptional regulator FSZ17_RS02510 ENOG41067QW Transcriptional regulator FSZ17_RS02515 ENOG4105CJ1 ABC, transporter FSZ17_RS02520 ENOG4108TU7 Inherit from COG: (ABC) transporter FSZ17_RS02525 ENOG4105EEM helicase FSZ17_RS02530 ENOG4105D03 DNA-3-methyladenine glycosylase II FSZ17_RS02540 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FSZ17_RS02550 ENOG4105DVE abc transporter atp-binding protein FSZ17_RS02575 ENOG4105KTU Transcriptional regulator, arsr family FSZ17_RS02580 ENOG4105PGM cation diffusion facilitator family transporter FSZ17_RS02590 ENOG4105E0M Sulfatase FSZ17_RS02605 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FSZ17_RS02610 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FSZ17_RS02615 ENOG4105CAQ asparagine synthetase FSZ17_RS02625 ENOG4105CG9 aspartate racemase FSZ17_RS02645 ENOG4105DMQ Methyltransferase FSZ17_RS02670 ENOG4105YVS arsR family transcriptional regulator FSZ17_RS02695 ENOG4105CUT histidyl-tRNA synthetase FSZ17_RS02715 ENOG4108HK0 -acetyltransferase FSZ17_RS02735 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FSZ17_RS02760 ENOG4105Z8B NlpC/P60 family FSZ17_RS02765 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FSZ17_RS02775 ENOG4107QWE )-transporter FSZ17_RS02800 ENOG4105CVJ phosphoglycerate mutase FSZ17_RS02815 ENOG4105ECQ AraC Family Transcriptional Regulator FSZ17_RS02820 ENOG4105CGP Urocanate hydratase FSZ17_RS02825 ENOG4105CI2 imidazolone-5-propionate hydrolase FSZ17_RS02830 ENOG4107W25 arginase agmatinase formiminoglutamase FSZ17_RS02835 ENOG4105DWD nucleoside recognition domain protein FSZ17_RS02840 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FSZ17_RS02850 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FSZ17_RS02865 ENOG4108ME1 Peptidase M55 D-aminopeptidase FSZ17_RS02870 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FSZ17_RS02875 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSZ17_RS02880 ENOG4105C3U ABC transporter FSZ17_RS02890 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FSZ17_RS02895 ENOG4105DTQ mandelate racemase muconate lactonizing FSZ17_RS02900 ENOG4107SN7 NLP P60 protein FSZ17_RS02905 ENOG4108JQ7 (ABC) transporter FSZ17_RS02920 ENOG4105CZN Potassium uptake protein FSZ17_RS02940 ENOG4108RMU ferritin dps family protein FSZ17_RS02955 ENOG4105C3U ABC transporter FSZ17_RS02960 ENOG4108JQ7 (ABC) transporter FSZ17_RS02965 ENOG4107258 Transcriptional regulator FSZ17_RS02970 ENOG4105DEF Extracellular solute-binding protein, family 5 FSZ17_RS02980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSZ17_RS02995 ENOG4105P4J Allophanate hydrolase, subunit 1 FSZ17_RS03000 ENOG4105E7W lamb ycsf family protein FSZ17_RS03005 ENOG4107R7A Allophanate hydrolase subunit 2 FSZ17_RS03015 ENOG4105CJW magnesium transporter FSZ17_RS03030 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FSZ17_RS03035 ENOG4105EHG Permease protein FSZ17_RS03040 ENOG4105E0A ABC, transporter FSZ17_RS03045 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FSZ17_RS03050 ENOG4107QZB decarboxylase FSZ17_RS03060 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FSZ17_RS03065 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FSZ17_RS03080 ENOG4108WBT adenosyltransferase FSZ17_RS03120 ENOG4105CPF Cell wall formation (By similarity) FSZ17_RS03125 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FSZ17_RS03135 ENOG4105EMN RNA polymerase sigma factor FSZ17_RS03155 ENOG4105DVE abc transporter atp-binding protein FSZ17_RS03165 ENOG4105C1J atp-dependent rna helicase FSZ17_RS03175 ENOG410905X membrane-flanked domain protein FSZ17_RS03180 ENOG4105CKV Membrane FSZ17_RS03185 ENOG4106YBV Methyl-accepting chemotaxis FSZ17_RS03200 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FSZ17_RS03205 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FSZ17_RS03220 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FSZ17_RS03320 ENOG4105K8N protein family UPF0079, ATPase FSZ17_RS03325 ENOG41072GX Peptidase M22 Glycoprotease FSZ17_RS03330 ENOG410801F ribosomal-protein-alanine acetyltransferase FSZ17_RS03335 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FSZ17_RS03340 ENOG4105C5H ABC transporter FSZ17_RS03345 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FSZ17_RS03350 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FSZ17_RS03360 ENOG4108TYN CAAX amino terminal protease family protein FSZ17_RS03365 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FSZ17_RS03370 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FSZ17_RS03410 ENOG4105VTR Integrase FSZ17_RS03440 ENOG4107TXC Transcriptional regulator FSZ17_RS03460 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FSZ17_RS03480 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin FSZ17_RS03495 ENOG4108IGT Dipeptidase FSZ17_RS03500 ENOG4107VRI Transcriptional regulator FSZ17_RS03510 ENOG4105EUB pirin domain protein FSZ17_RS03520 ENOG4105KVH Transcriptional regulator FSZ17_RS03560 ENOG4108TF4 von Willebrand factor, type A FSZ17_RS03590 ENOG4108TF4 von Willebrand factor, type A FSZ17_RS03615 ENOG4105F1A Pyruvate formate-lyase FSZ17_RS03620 ENOG4105C0A alcohol dehydrogenase FSZ17_RS03630 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FSZ17_RS03635 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FSZ17_RS03645 ENOG4108TF4 von Willebrand factor, type A FSZ17_RS03650 ENOG4108TF4 von Willebrand factor, type A FSZ17_RS03660 ENOG4108TF4 von Willebrand factor, type A FSZ17_RS03670 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FSZ17_RS03685 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FSZ17_RS03690 ENOG4105C7N Xanthine uracil vitamin C permease FSZ17_RS03720 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FSZ17_RS03725 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FSZ17_RS03730 ENOG4105C83 adenylosuccinate lyase FSZ17_RS03735 ENOG4105C8V SAICAR synthetase FSZ17_RS03740 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FSZ17_RS03745 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FSZ17_RS03765 ENOG4108V3E phosphoribosylglycinamide formyltransferase FSZ17_RS03770 ENOG4105DC1 bifunctional purine biosynthesis protein purh FSZ17_RS03775 ENOG4105C12 Phosphoribosylglycinamide synthetase FSZ17_RS03790 ENOG4108R5T secreted protein FSZ17_RS03795 ENOG4105KGF protein, YerC YecD FSZ17_RS03800 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) FSZ17_RS03805 ENOG4105C4R Atp-dependent dna helicase FSZ17_RS03810 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FSZ17_RS03820 ENOG4105C26 Dehydrogenase FSZ17_RS03875 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FSZ17_RS03880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FSZ17_RS03885 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FSZ17_RS03890 ENOG4108IMY Transcriptional regulator FSZ17_RS03895 ENOG4105DY9 regulatoR FSZ17_RS03920 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FSZ17_RS03925 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FSZ17_RS03935 ENOG4105EMN RNA polymerase sigma factor FSZ17_RS03955 ENOG4105CBD Diacylglycerol kinase FSZ17_RS03970 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FSZ17_RS03980 ENOG41088CC tellurite resistance protein tehB FSZ17_RS03990 ENOG4105E5W Transporter FSZ17_RS04005 ENOG4105DRS transport system, permease FSZ17_RS04015 ENOG4108JE9 extracellular solute-binding protein family 1 FSZ17_RS04025 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FSZ17_RS04040 ENOG4108KMM Diguanylate cyclase FSZ17_RS04075 ENOG4107Y80 Major Facilitator superfamily FSZ17_RS04080 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FSZ17_RS04085 ENOG4107YUH hydrolase FSZ17_RS04095 ENOG4105KVH Transcriptional regulator FSZ17_RS04105 ENOG4105C0R drug resistance transporter emrb qaca subfamily FSZ17_RS04110 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FSZ17_RS04130 ENOG4107RGD Major Facilitator superfamily FSZ17_RS04150 ENOG4105CJZ response regulator FSZ17_RS04155 ENOG4105EWM Histidine kinase FSZ17_RS04165 ENOG4108HVR ABC transporter, permease FSZ17_RS04170 ENOG4105C19 ABC transporter FSZ17_RS04175 ENOG4105IIU Aminopeptidase FSZ17_RS04185 ENOG4105C28 cystathionine FSZ17_RS04190 ENOG4105CUC YeeE YedE family protein FSZ17_RS04200 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FSZ17_RS04205 ENOG4107YZX Universal stress protein FSZ17_RS04215 ENOG4105CDW Resistance protein FSZ17_RS04220 ENOG4105BZU Histidine kinase FSZ17_RS04230 ENOG4105CHU acetyl-coa acetyltransferase FSZ17_RS04240 ENOG4106IPI cyclase, family FSZ17_RS04245 ENOG4105DZS Phenylacetate-CoA ligase FSZ17_RS04250 ENOG41079KZ Major Facilitator Superfamily FSZ17_RS04260 ENOG4105C3M thioredoxin reductase FSZ17_RS04265 ENOG4105IIU Aminopeptidase FSZ17_RS04275 ENOG4106FN3 tellurium resistance protein FSZ17_RS04290 ENOG4105CX6 glutaminyL-tRNA synthetase FSZ17_RS04310 ENOG4105D65 subunit l FSZ17_RS04315 ENOG4105HC0 Na H antiporter FSZ17_RS04320 ENOG4105MKQ Monovalent cation H antiporter subunit C FSZ17_RS04325 ENOG4108JPZ Monovalent cation H antiporter subunit D FSZ17_RS04330 ENOG4105SC1 monovalent cation H antiporter subunit E FSZ17_RS04340 ENOG4105KJM monovalent cation h antiporter subunit g FSZ17_RS04345 ENOG4105CFH Aspartokinase FSZ17_RS04355 ENOG4105CIY formyltetrahydrofolate deformylase FSZ17_RS04365 ENOG4107TS3 membrane protein, TerC FSZ17_RS04385 ENOG4105CDY transcriptional regulatory protein FSZ17_RS04405 ENOG4105EMN RNA polymerase sigma factor FSZ17_RS04430 ENOG4105MA6 gCN5-related N-acetyltransferase FSZ17_RS04435 ENOG4105C8Q Methyl-accepting chemotaxis FSZ17_RS04445 ENOG4107RBI VanW family FSZ17_RS04460 ENOG4105K5X acetyltransferase FSZ17_RS04490 ENOG4105IIU Aminopeptidase FSZ17_RS04515 ENOG4108SUT Major Facilitator Superfamily FSZ17_RS04535 ENOG4107Y9U Membrane FSZ17_RS04545 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FSZ17_RS04565 ENOG4105DY9 regulatoR FSZ17_RS04570 ENOG4105CYC Transferase FSZ17_RS04605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FSZ17_RS04610 ENOG4105BZU Histidine kinase FSZ17_RS04640 ENOG4105C0H protease FSZ17_RS04645 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FSZ17_RS04650 ENOG4105G6Z alkaline phosphatase FSZ17_RS04655 ENOG4105KPY Small multidrug resistance protein FSZ17_RS04660 ENOG4105C0X amino acid FSZ17_RS04665 ENOG4105CKI cobalamin synthesis protein FSZ17_RS04670 ENOG4105WDJ 50S ribosomal protein L33 FSZ17_RS04675 ENOG4108MK9 spermidine N(1)-acetyltransferase FSZ17_RS04685 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FSZ17_RS04700 ENOG4105E98 transcriptional regulator DeoR family FSZ17_RS04710 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FSZ17_RS04715 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FSZ17_RS04740 ENOG4105DA5 (ABC) transporter FSZ17_RS04755 ENOG4105F6E Acyl-transferase FSZ17_RS04765 ENOG4105JVQ RNA Polymerase FSZ17_RS04785 ENOG4107ZXU DSBA oxidoreductase FSZ17_RS04790 ENOG4105JVQ RNA Polymerase FSZ17_RS04805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSZ17_RS04810 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FSZ17_RS04815 ENOG4108JQ6 ABC transporter FSZ17_RS04825 ENOG4105DTE Xanthine uracil vitamin C permease FSZ17_RS04840 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FSZ17_RS04845 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FSZ17_RS04855 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FSZ17_RS04875 ENOG4107EFR Flavocytochrome c FSZ17_RS04885 ENOG4105CUW cytochrome C-TYPE protein FSZ17_RS04910 ENOG4105EWM Histidine kinase FSZ17_RS04915 ENOG4105C19 ABC transporter FSZ17_RS04925 ENOG4105CK7 Sodium proline symporter FSZ17_RS04940 ENOG4105DR4 Methyltransferase FSZ17_RS04945 ENOG4107R37 Glutamate dehydrogenase FSZ17_RS04950 ENOG4105C5Q Transcriptional regulator FSZ17_RS05020 ENOG4105VEQ Cold shock protein FSZ17_RS05045 ENOG4107ZXU DSBA oxidoreductase FSZ17_RS05055 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FSZ17_RS05075 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FSZ17_RS05090 ENOG4108YTE sporulation protein YunB FSZ17_RS05100 ENOG4108NEV two component transcriptional regulator, LytTR family FSZ17_RS05105 ENOG4108HRK Histidine kinase FSZ17_RS05115 ENOG4107TXC Transcriptional regulator FSZ17_RS05120 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FSZ17_RS05125 ENOG4105C8Q Methyl-accepting chemotaxis FSZ17_RS05130 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FSZ17_RS05135 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FSZ17_RS05165 ENOG4105BZG amino acid carrier protein FSZ17_RS05175 ENOG4105FDU atp-dependent rna helicase FSZ17_RS05190 ENOG41073R8 VanW family FSZ17_RS05200 ENOG41087YS Phage shock protein A FSZ17_RS05210 ENOG4105ENE Histidine kinase FSZ17_RS05215 ENOG4105WH1 Two component transcriptional regulator luxr family FSZ17_RS05220 ENOG4105H67 Protein of unknown function (DUF421) FSZ17_RS05240 ENOG4108S4H thioesterase Superfamily protein FSZ17_RS05245 ENOG4107XI7 Tetr family transcriptional regulator FSZ17_RS05255 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FSZ17_RS05260 ENOG4105BZU Histidine kinase FSZ17_RS05275 ENOG4105I4A GCN5-related N-acetyltransferase FSZ17_RS05280 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FSZ17_RS05290 ENOG4105D1U peptidase U62 modulator of DNA gyrase FSZ17_RS05295 ENOG4105CMS peptidase U62, modulator of DNA gyrase FSZ17_RS05300 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FSZ17_RS05305 ENOG4106I4J membrane FSZ17_RS05310 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FSZ17_RS05320 ENOG4108IA2 Sodium pantothenate symporter FSZ17_RS05350 ENOG4105DAA L-lactate FSZ17_RS05355 ENOG4108NHD germination protein FSZ17_RS05360 ENOG4108Q8B Spore germination protein FSZ17_RS05375 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FSZ17_RS05405 ENOG4105C84 Histidine ammonia-lyase FSZ17_RS05430 ENOG4105E14 MotA TolQ exbB proton channel FSZ17_RS05435 ENOG4105ER2 Ompa motb domain protein FSZ17_RS05515 ENOG4105CZM Major Facilitator FSZ17_RS05520 ENOG4107MII Sugar-specific transcriptional regulator TrmB FSZ17_RS05540 ENOG4105DA5 (ABC) transporter FSZ17_RS05550 ENOG4105DD7 kinase (PfkB family FSZ17_RS05555 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FSZ17_RS05570 ENOG4105VFR signal peptidase FSZ17_RS05605 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) FSZ17_RS05620 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FSZ17_RS05625 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FSZ17_RS05630 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FSZ17_RS05640 ENOG4105DB1 molybdopterin oxidoreductase FSZ17_RS05650 ENOG41068PA UPF0435 protein FSZ17_RS05655 ENOG4105KJF protein tyrosine phosphatase FSZ17_RS05665 ENOG4107U9T Pfam:Ribonuclease_BN FSZ17_RS05670 ENOG4105C59 p-type ATPase FSZ17_RS05680 ENOG4108ISG Major Facilitator FSZ17_RS05685 ENOG4105UPD Calcium Proton FSZ17_RS05695 ENOG4105BZU Histidine kinase FSZ17_RS05700 ENOG4105WH1 Two component transcriptional regulator luxr family FSZ17_RS05705 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FSZ17_RS05725 ENOG4105BZ4 penicillin-binding protein FSZ17_RS05745 ENOG4105VMP Transcriptional regulator FSZ17_RS05750 ENOG4105NX3 Membrane FSZ17_RS05765 ENOG4105DFD Na H antiporter FSZ17_RS05775 ENOG4105DTQ mandelate racemase muconate lactonizing FSZ17_RS05800 ENOG4105C94 Transporter FSZ17_RS05810 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FSZ17_RS05815 ENOG4107BJW polysaccharide deacetylase FSZ17_RS05835 ENOG4108W15 Protein of unknown function (DUF1456) FSZ17_RS05845 ENOG4105CVA phosphate FSZ17_RS05850 ENOG4105C8U phosphate abc transporter FSZ17_RS05855 ENOG4105E2Z phosphate ABC transporter (Permease FSZ17_RS05865 ENOG4108UTW Plays a role in the regulation of phosphate uptake FSZ17_RS05875 ENOG4105CI1 PTS System FSZ17_RS05895 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FSZ17_RS05900 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FSZ17_RS05905 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FSZ17_RS05925 ENOG4105K70 DNA-binding protein FSZ17_RS05930 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FSZ17_RS05950 ENOG4108ZMX Domain of unknown function (DU1801) FSZ17_RS05955 ENOG4105CZ9 Domain of unknown function (DU1801) FSZ17_RS05960 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FSZ17_RS05990 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FSZ17_RS06005 ENOG4105C1J atp-dependent rna helicase FSZ17_RS06010 ENOG4105CMU LysR family (Transcriptional regulator FSZ17_RS06015 ENOG4108S4H thioesterase Superfamily protein FSZ17_RS06025 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FSZ17_RS06055 ENOG4105EHZ conserved protein UCP016719 FSZ17_RS06060 ENOG4105D17 glycoside hydrolase, family 3 domain protein FSZ17_RS06085 ENOG41069ER domain protein FSZ17_RS06095 ENOG4105FE9 pseudouridine synthase FSZ17_RS06125 ENOG4105CTB Polyprenyl synthetase FSZ17_RS06215 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 FSZ17_RS06225 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FSZ17_RS06230 ENOG4105UQX Mate efflux family protein FSZ17_RS06240 ENOG4105E1K spore germination protein FSZ17_RS06255 ENOG4105EMN RNA polymerase sigma factor FSZ17_RS06265 ENOG4105CNI cell division protein FtsW FSZ17_RS06280 ENOG4108FUT Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FSZ17_RS06295 ENOG4108RE7 deoxyribonuclease FSZ17_RS06305 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FSZ17_RS06315 ENOG4107Z6I Thiamine biosynthesis protein FSZ17_RS06345 ENOG4105BZU Histidine kinase FSZ17_RS06350 ENOG4105C0H protease FSZ17_RS06375 ENOG4105CE4 GlcNAc 6-P deacetylase FSZ17_RS06385 ENOG4105BZU Histidine kinase FSZ17_RS06410 ENOG41086D8 Transcriptional regulator FSZ17_RS06430 ENOG4105DJ2 Major Facilitator Superfamily FSZ17_RS06435 ENOG4106U2H Protein of unknown function (DUF1360) FSZ17_RS06440 ENOG4105EXC Acyl-transferase FSZ17_RS06480 ENOG4105BZ1 (ABC) transporter FSZ17_RS06485 ENOG4105BZ1 (ABC) transporter FSZ17_RS06505 ENOG4105ECP epimerase FSZ17_RS06510 ENOG410902V Modulates RecA activity (By similarity) FSZ17_RS06515 ENOG4105CHR reductase FSZ17_RS06530 ENOG4105XHU Acid-soluble spore protein K FSZ17_RS06535 ENOG41067AE Membrane-bound metal-dependent hydrolase FSZ17_RS06540 ENOG4105CEN a g-specific adenine glycosylase FSZ17_RS06545 ENOG4106BXE FSZ17_RS06550 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FSZ17_RS06570 ENOG4105BZ1 (ABC) transporter FSZ17_RS06575 ENOG4107NBY Membrane FSZ17_RS06580 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FSZ17_RS06595 ENOG4105G5W regulator Fur family FSZ17_RS06600 ENOG4105TUA UPF0295 protein FSZ17_RS06800 ENOG4105HHM rdd domain containing protein FSZ17_RS06820 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FSZ17_RS06850 ENOG4105CZM Major Facilitator FSZ17_RS06855 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FSZ17_RS06905 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FSZ17_RS06940 ENOG4105ESF Peptidoglycan binding domain protein FSZ17_RS07000 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FSZ17_RS07020 ENOG41069I7 FSZ17_RS07045 ENOG41082BM Transcriptional regulator, arsr family FSZ17_RS07060 ENOG4105CHR reductase FSZ17_RS07070 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FSZ17_RS07080 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FSZ17_RS07115 ENOG4105D7W serine acetyltransferase FSZ17_RS07125 ENOG4105CAK Cell division ATP-binding protein ftsE FSZ17_RS07145 ENOG4105W8Z 4'-phosphopantetheinyl transferase FSZ17_RS07155 ENOG4105DHF Membrane FSZ17_RS07160 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FSZ17_RS07180 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FSZ17_RS07190 ENOG4105DZC cytosine deaminase FSZ17_RS07195 ENOG4105DZC cytosine deaminase FSZ17_RS07200 ENOG4105E98 transcriptional regulator DeoR family FSZ17_RS07205 ENOG4105G63 Type III effector Hrp-dependent FSZ17_RS07220 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FSZ17_RS07230 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FSZ17_RS07235 ENOG4108DBC nitroreductase FSZ17_RS07240 ENOG4105CYN Serine protein kinase FSZ17_RS07245 ENOG4106AKX UPF0229 protein FSZ17_RS07250 ENOG4105C3U ABC transporter FSZ17_RS07255 ENOG4108JQ7 (ABC) transporter FSZ17_RS07260 ENOG4105DEF Extracellular solute-binding protein, family 5 FSZ17_RS07265 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FSZ17_RS07270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSZ17_RS07275 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FSZ17_RS07280 ENOG4106IPI cyclase, family FSZ17_RS07300 ENOG4105II7 pyrroline-5-carboxylate reductase FSZ17_RS07310 ENOG4107R6U sodium dicarboxylate symporter FSZ17_RS07315 ENOG4105C7N Xanthine uracil vitamin C permease FSZ17_RS07325 ENOG4105CJ3 phosphate transporter FSZ17_RS07330 ENOG4107GRR phosphate transport regulator FSZ17_RS07335 ENOG4105CA0 peroxidase FSZ17_RS07340 ENOG4107BMA Transglycosylase associated protein FSZ17_RS07345 ENOG4108YBP pseudouridine synthase FSZ17_RS07355 ENOG4105K63 Thioredoxin FSZ17_RS07360 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) FSZ17_RS07375 ENOG4105BZU Histidine kinase FSZ17_RS07380 ENOG4105WH1 Two component transcriptional regulator luxr family FSZ17_RS07395 ENOG4105ED1 spovr family FSZ17_RS07400 ENOG4108JYZ YitT family FSZ17_RS07405 ENOG4108JYZ YitT family FSZ17_RS07410 ENOG4107YTP response regulator receiver protein FSZ17_RS07420 ENOG4105C7N Xanthine uracil vitamin C permease FSZ17_RS07430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FSZ17_RS07435 ENOG4105BZU Histidine kinase FSZ17_RS07440 ENOG4105C37 (CBS) domain FSZ17_RS07450 ENOG4105C37 (CBS) domain FSZ17_RS07460 ENOG4105BZU Histidine kinase FSZ17_RS07485 ENOG4105BZ4 penicillin-binding protein FSZ17_RS07515 ENOG4105C9Q fumarate hydratase class II FSZ17_RS07545 ENOG410839P FSZ17_RS07550 ENOG410839P FSZ17_RS07570 ENOG4105WZB UPF0342 protein FSZ17_RS07585 ENOG4105D4P Coproporphyrinogen iii oxidase FSZ17_RS07590 ENOG4105CEY Amp-dependent synthetase and ligase FSZ17_RS07595 ENOG4105CGU Enoyl-CoA hydratase FSZ17_RS07605 ENOG4108IUX (ABC) transporter FSZ17_RS07610 ENOG4105RHA ABC transporter, permease FSZ17_RS07615 ENOG4107VRP DNA repair exonuclease FSZ17_RS07620 ENOG4106D4I domain protein FSZ17_RS07635 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FSZ17_RS07665 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) FSZ17_RS07680 ENOG4105NBU tryptophan transport protein FSZ17_RS07695 ENOG4105K59 histidine triad (HIT) protein FSZ17_RS07725 ENOG410841Q phosphoesterase PA-phosphatase related protein FSZ17_RS07740 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FSZ17_RS07745 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FSZ17_RS07750 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FSZ17_RS07755 ENOG4105C1Q protoporphyrinogen oxidase FSZ17_RS07765 ENOG4105ECB domain protein FSZ17_RS07770 ENOG4106AXD FSZ17_RS07775 ENOG4108RQ5 Beta-lactamase domain-containing protein FSZ17_RS07780 ENOG4105DF9 Lipoate-protein, ligase FSZ17_RS07785 ENOG4105JVQ RNA Polymerase FSZ17_RS07790 ENOG4108P49 AntiSigma factor FSZ17_RS07795 ENOG4105CEY Amp-dependent synthetase and ligase FSZ17_RS07800 ENOG4105E39 Enoyl-CoA hydratase FSZ17_RS07810 ENOG4105C7J ABC transporter, permease FSZ17_RS07815 ENOG4108JJB ABC transporter FSZ17_RS07820 ENOG4108JCI Transcriptional regulator FSZ17_RS07830 ENOG4108UMN azlc family FSZ17_RS07840 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FSZ17_RS07850 ENOG4105XVF Competence transcription factor FSZ17_RS07855 ENOG41060YP FSZ17_RS07860 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FSZ17_RS07865 ENOG4108KGH TRANSCRIPTIONal FSZ17_RS07890 ENOG4105C0Z ABC transporter FSZ17_RS07895 ENOG4108IV0 ABC, transporter FSZ17_RS07900 ENOG4105C32 Amino acid ABC transporter (Permease) FSZ17_RS07920 ENOG4105CHR reductase FSZ17_RS07925 ENOG4105CEY Amp-dependent synthetase and ligase FSZ17_RS07980 ENOG4105CEY Amp-dependent synthetase and ligase FSZ17_RS07985 ENOG4105ERH Fumarylacetoacetate hydrolase FSZ17_RS07990 ENOG4105YHS UPF0344 protein FSZ17_RS07995 ENOG4105BZU Histidine kinase FSZ17_RS08005 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FSZ17_RS08010 ENOG4108VPT UPF0234 protein FSZ17_RS08015 ENOG4105QNR S1 RNA binding domain protein FSZ17_RS08025 ENOG4105EPR degv family FSZ17_RS08030 ENOG4107AYK membrAne FSZ17_RS08040 ENOG41073B9 FSZ17_RS08045 ENOG4108KP7 hydrolase FSZ17_RS08050 ENOG4108MXZ Esterase FSZ17_RS08055 ENOG4105VG1 fes assembly suf system protein FSZ17_RS08070 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FSZ17_RS08075 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FSZ17_RS08080 ENOG4105CVM Molybdenum cofactor synthesis domain protein FSZ17_RS08085 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FSZ17_RS08095 ENOG4107V6Q Cyclic nucleotide-binding domain FSZ17_RS08100 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FSZ17_RS08105 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FSZ17_RS08110 ENOG4105CAS nag kinase FSZ17_RS08130 ENOG4105DBV ornithine carbamoyltransferase FSZ17_RS08140 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FSZ17_RS08160 ENOG4107RMD Basic membrane lipoprotein FSZ17_RS08170 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FSZ17_RS08175 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FSZ17_RS08185 ENOG4105C3U ABC transporter FSZ17_RS08190 ENOG4108JQ7 (ABC) transporter FSZ17_RS08205 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSZ17_RS08210 ENOG4108KU1 UPF0736 protein FSZ17_RS08215 ENOG4105C31 Tryptophanyl-tRNA synthetase FSZ17_RS08220 ENOG4108J59 Extracellular solute-binding protein, family 5 FSZ17_RS08225 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FSZ17_RS08230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSZ17_RS08240 ENOG4108JQ7 (ABC) transporter FSZ17_RS08255 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FSZ17_RS08260 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis FSZ17_RS08265 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FSZ17_RS08275 ENOG4105DPN Oligoendopeptidase f FSZ17_RS08280 ENOG4105T58 Dithiol-disulfide isomerase FSZ17_RS08285 ENOG4108Z18 K06886 hemoglobin FSZ17_RS08290 ENOG4105E4C Lytic transglycosylase catalytic FSZ17_RS08295 ENOG4105MIX Adenylate cyclase FSZ17_RS08300 ENOG4106EFP UPF0738 protein FSZ17_RS08315 ENOG4105EMS pseudouridine synthase FSZ17_RS08320 ENOG4107S1Q Phosphatase FSZ17_RS08325 ENOG4105CJW magnesium transporter FSZ17_RS08335 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FSZ17_RS08360 ENOG41090VF Stage v sporulation protein ac FSZ17_RS08365 ENOG4105CZ3 stage V sporulation protein ad FSZ17_RS08380 ENOG4105ENA helicase FSZ17_RS08395 ENOG4108ZMI UPF0477 protein FSZ17_RS08405 ENOG4105H1G trap transporter solute receptor taxi family FSZ17_RS08420 ENOG4108IUW ABC transporter FSZ17_RS08450 ENOG4105BZ9 Cytochrome C oxidase, subunit I FSZ17_RS08455 ENOG4105E2S oxidase) subunit II FSZ17_RS08475 ENOG4105E5Q amino acid AbC transporter FSZ17_RS08500 ENOG4105DEU major facilitator superfamily FSZ17_RS08515 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FSZ17_RS08540 ENOG4105E1K spore germination protein FSZ17_RS08585 ENOG4105DZ6 Band 7 protein FSZ17_RS08605 ENOG4108AEY RNA polymerase sigma factor FSZ17_RS08620 ENOG4105F0V Cell wall hydrolase FSZ17_RS08630 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FSZ17_RS08635 ENOG4105DFD Na H antiporter FSZ17_RS08650 ENOG4108WZW RNA polymerase sigma FSZ17_RS08660 ENOG410681C small acid-soluble spore protein FSZ17_RS08680 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FSZ17_RS08685 ENOG4107QR9 Iron-sulfur cluster binding protein FSZ17_RS08690 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FSZ17_RS08700 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein FSZ17_RS08705 ENOG41068WN FSZ17_RS08715 ENOG4108TGC Acyltransferase FSZ17_RS08720 ENOG4105EJ5 oxidoreductase gamma subunit FSZ17_RS08725 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) FSZ17_RS08730 ENOG4105C8Q Methyl-accepting chemotaxis FSZ17_RS08735 ENOG4105BZU Histidine kinase FSZ17_RS08740 ENOG4105BZJ Electron transfer flavoprotein FSZ17_RS08745 ENOG4105C10 Electron transfer flavoprotein FSZ17_RS08765 ENOG4105EU0 Major facilitator Superfamily FSZ17_RS08770 ENOG4105CRN Aminoglycoside phosphotransferase FSZ17_RS08775 ENOG4105BZU Histidine kinase FSZ17_RS08780 ENOG41090MY MarR family Transcriptional regulator FSZ17_RS08795 ENOG4108K88 Membrane FSZ17_RS08835 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FSZ17_RS08845 ENOG41085PJ rdd domain containing protein FSZ17_RS08855 ENOG4107R88 Chemotaxis protein (CheV) FSZ17_RS08860 ENOG4105UIN FSZ17_RS08865 ENOG4105BZU Histidine kinase FSZ17_RS08875 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FSZ17_RS08880 ENOG4105CRK lysyL-tRNA synthetase FSZ17_RS08885 ENOG4108IJ0 Aspartate ammonia-lyase FSZ17_RS08890 ENOG4105EPM Diguanylate phosphodiesterase FSZ17_RS08905 ENOG4107IN1 Protein of unknown function (DUF1797) FSZ17_RS08920 ENOG4105D3R alkyl hydroperoxide reductase FSZ17_RS08925 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FSZ17_RS08935 ENOG4105BZ1 (ABC) transporter FSZ17_RS08940 ENOG4105BZ1 (ABC) transporter FSZ17_RS08950 ENOG4105CHM Aminotransferase FSZ17_RS08955 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FSZ17_RS08960 ENOG4105C5F glutamine synthetase FSZ17_RS08965 ENOG4105CAQ asparagine synthetase FSZ17_RS08970 ENOG4107ZYR domain protein FSZ17_RS08975 ENOG4105CN5 Metallo-Beta-Lactamase FSZ17_RS08980 ENOG4106148 UPF0356 protein FSZ17_RS08985 ENOG4108X4Q Hydrolase FSZ17_RS09010 ENOG4105CPP Dehydrogenase, E1 component FSZ17_RS09050 ENOG4105CXN decarboxylase FSZ17_RS09055 ENOG4105EA8 2-Nitropropane dioxygenase FSZ17_RS09060 ENOG4105WBI UPF0223 protein FSZ17_RS09075 ENOG4105ECY inositol monophosphatase FSZ17_RS09085 ENOG4105CI3 gtp-binding protein typa FSZ17_RS09090 ENOG4105QA2 FSZ17_RS09115 ENOG4108IAB Phoh family FSZ17_RS09125 ENOG4105CSV Glutaminase FSZ17_RS09135 ENOG4105CNI cell division protein FtsW FSZ17_RS09140 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FSZ17_RS09145 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FSZ17_RS09150 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FSZ17_RS09200 ENOG41080XQ Signal transduction protein with cbs domains FSZ17_RS09205 ENOG4106UY4 Inherit from COG: Scp-like extracellular FSZ17_RS09240 ENOG4105WUC UPF0298 protein FSZ17_RS09255 ENOG4106H78 methyltransferase FSZ17_RS09260 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FSZ17_RS09265 ENOG4105H20 Sporulation integral membrane protein YlbJ FSZ17_RS09270 ENOG4105D78 K07001 NTE family protein FSZ17_RS09275 ENOG41063PX domain protein FSZ17_RS09280 ENOG4105CDE UPF0348 protein FSZ17_RS09285 ENOG4105KNH Nucleic acid-binding protein FSZ17_RS09290 ENOG41067VY 50S ribosomal protein L32 FSZ17_RS09295 ENOG4105E39 Enoyl-CoA hydratase FSZ17_RS09305 ENOG4108YG3 N-acetyltransferase FSZ17_RS09310 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FSZ17_RS09315 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FSZ17_RS09320 ENOG4107QX3 carboxylase FSZ17_RS09335 ENOG41074B2 UPF0747 protein FSZ17_RS09340 ENOG4108V6E Cell division protein mraZ FSZ17_RS09350 ENOG41068DC Essential cell division protein (By similarity) FSZ17_RS09355 ENOG4105CJN penicillin-binding protein FSZ17_RS09360 ENOG4105CJN penicillin-binding protein FSZ17_RS09365 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FSZ17_RS09375 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FSZ17_RS09380 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FSZ17_RS09385 ENOG4105CNI cell division protein FtsW FSZ17_RS09390 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FSZ17_RS09395 ENOG4105D4A Cell wall formation (By similarity) FSZ17_RS09400 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FSZ17_RS09405 ENOG4108R2U division initiation protein FSZ17_RS09415 ENOG4105K67 small basic protein FSZ17_RS09420 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FSZ17_RS09425 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FSZ17_RS09435 ENOG4108AWX Sporulation factor SpoIIGA FSZ17_RS09440 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FSZ17_RS09450 ENOG4105WR5 sporulation protein, YlmC YmxH family FSZ17_RS09455 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FSZ17_RS09460 ENOG4105DFA alanine racemase domain protein FSZ17_RS09465 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FSZ17_RS09470 ENOG41067XK integral membrane protein FSZ17_RS09475 ENOG4105DBK s4 domain protein FSZ17_RS09485 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FSZ17_RS09500 ENOG4105C34 Pseudouridine synthase FSZ17_RS09505 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FSZ17_RS09515 ENOG4105CXT aspartate transcarbamylase FSZ17_RS09520 ENOG4105CD3 dihydroorotase FSZ17_RS09525 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FSZ17_RS09535 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FSZ17_RS09565 ENOG4105DSJ YicC domain protein FSZ17_RS09570 ENOG4105KC4 UPF0296 protein FSZ17_RS09575 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FSZ17_RS09585 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FSZ17_RS09590 ENOG4105C25 Primosomal protein n' FSZ17_RS09600 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FSZ17_RS09605 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FSZ17_RS09610 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FSZ17_RS09615 ENOG4108ZF3 Phosphatase FSZ17_RS09620 ENOG4105D9P serine threonine protein kinase FSZ17_RS09625 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FSZ17_RS09630 ENOG4105DJV ribulose-phosphate 3-epimerase FSZ17_RS09635 ENOG4105FJ0 thiamine FSZ17_RS09645 ENOG4105VB9 50S ribosomal protein l28 FSZ17_RS09650 ENOG4108ZAA Alkaline-shock protein FSZ17_RS09655 ENOG4105DP4 dak2 domain fusion protein ylov FSZ17_RS09660 ENOG4105CB5 ATP-dependent DNA helicase recG FSZ17_RS09665 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) FSZ17_RS09670 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FSZ17_RS09675 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FSZ17_RS09680 ENOG4105CHR reductase FSZ17_RS09685 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FSZ17_RS09690 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FSZ17_RS09695 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FSZ17_RS09700 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FSZ17_RS09710 ENOG4105CJ1 ABC, transporter FSZ17_RS09725 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FSZ17_RS09745 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) FSZ17_RS09755 ENOG4105K5M 30s ribosomal protein S16 FSZ17_RS09760 ENOG4105VB6 UPF0109 protein FSZ17_RS09770 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FSZ17_RS09775 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FSZ17_RS09780 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FSZ17_RS09790 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FSZ17_RS09805 ENOG4105VM1 flagellar FSZ17_RS09810 ENOG4105CMV Succinyl-CoA synthetase subunit beta FSZ17_RS09815 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FSZ17_RS09820 ENOG4105C79 DNA protecting protein DprA FSZ17_RS09825 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FSZ17_RS09830 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FSZ17_RS09835 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FSZ17_RS09840 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FSZ17_RS09845 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FSZ17_RS09850 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) FSZ17_RS09855 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FSZ17_RS09860 ENOG4108ZC9 flagellar basal-body rod protein flgc FSZ17_RS09865 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FSZ17_RS09870 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FSZ17_RS09875 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FSZ17_RS09890 ENOG4106YF4 Flagellar biosynthesis chaperone FSZ17_RS09905 ENOG410822I Flagellar hook capping protein FSZ17_RS09915 ENOG4105BZE flagellar hook protein, FlgE FSZ17_RS09920 ENOG41068WV flagellar FlbD family protein FSZ17_RS09930 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FSZ17_RS09935 ENOG4105DD5 Flagellar motor switch protein FSZ17_RS09940 ENOG4107YTP response regulator receiver protein FSZ17_RS09950 ENOG4105CN7 Flagellar biosynthetic protein FliP FSZ17_RS09955 ENOG4105VS8 Flagellar biosynthetic protein fliq FSZ17_RS09960 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FSZ17_RS09965 ENOG4105D00 flagellar biosynthetic protein flhB FSZ17_RS09970 ENOG4105D7B Flagellar biosynthesis protein flha FSZ17_RS09975 ENOG4105FZW flagellar biosynthesis regulator FlhF FSZ17_RS09985 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FSZ17_RS09990 ENOG4105CBS Chea signal transduction histidine kinase FSZ17_RS09995 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis FSZ17_RS10010 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FSZ17_RS10030 ENOG4105CE9 30S ribosomal protein S2 FSZ17_RS10045 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FSZ17_RS10050 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FSZ17_RS10055 ENOG4105KNE Phosphatidate cytidylyltransferase FSZ17_RS10065 ENOG4105DZP Membrane-associated zinc metalloprotease FSZ17_RS10070 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FSZ17_RS10075 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FSZ17_RS10080 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FSZ17_RS10085 ENOG4105CHV Transcription elongation factor NusA FSZ17_RS10090 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FSZ17_RS10095 ENOG4105VHM ribosomal protein FSZ17_RS10100 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FSZ17_RS10105 ENOG4105W7A Protein of unknown function (DUF503) FSZ17_RS10115 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FSZ17_RS10120 ENOG4105DTN riboflavin biosynthesis protein ribF FSZ17_RS10125 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FSZ17_RS10130 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FSZ17_RS10140 ENOG4105C1V Peptidase, M16 FSZ17_RS10150 ENOG4105E35 Dipicolinate synthase subunit A FSZ17_RS10155 ENOG4108S0H Dipicolinic acid synthetase, b subunit FSZ17_RS10160 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FSZ17_RS10170 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FSZ17_RS10180 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FSZ17_RS10190 ENOG4105CNU cell division protein FtsK FSZ17_RS10195 ENOG4105FDP GntR family transcriptional regulator FSZ17_RS10200 ENOG4105DIH basic membrane FSZ17_RS10205 ENOG4108JQ9 ABC transporter FSZ17_RS10210 ENOG4105UIB (ABC) transporter FSZ17_RS10230 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FSZ17_RS10235 ENOG4105XZV Protein of unknown function (DUF3243) FSZ17_RS10250 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FSZ17_RS10255 ENOG4105CEV competence damage-inducible protein FSZ17_RS10260 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FSZ17_RS10265 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) FSZ17_RS10270 ENOG4105D48 metallophosphoesterase FSZ17_RS10275 ENOG4105MCT stage V sporulation protein S FSZ17_RS10280 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FSZ17_RS10285 ENOG4105DQU oxidoreductase, subunit beta FSZ17_RS10290 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FSZ17_RS10305 ENOG4105N14 lysine exporter protein LysE YggA FSZ17_RS10310 ENOG4108QCI YvbH-like oligomerisation region FSZ17_RS10315 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FSZ17_RS10320 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FSZ17_RS10330 ENOG4105JQZ Methyltransferase FSZ17_RS10360 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FSZ17_RS10365 ENOG4106F1P AAA ATPase, central domain protein FSZ17_RS10370 ENOG4105EN6 Membrane FSZ17_RS10375 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FSZ17_RS10380 ENOG4105CXI aluminum resistance protein FSZ17_RS10385 ENOG4105KV4 Transcriptional regulator FSZ17_RS10390 ENOG4105C5F glutamine synthetase FSZ17_RS10405 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FSZ17_RS10410 ENOG41067Z0 domain protein FSZ17_RS10415 ENOG4108SVB resolvase FSZ17_RS10420 ENOG4105VPS UPF0291 protein FSZ17_RS10440 ENOG4105H67 Protein of unknown function (DUF421) FSZ17_RS10445 ENOG4105BZ1 (ABC) transporter FSZ17_RS10450 ENOG4105BZ1 (ABC) transporter FSZ17_RS10460 ENOG4107QIV Cytochrome c biogenesis protein FSZ17_RS10465 ENOG4107YTP response regulator receiver protein FSZ17_RS10520 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FSZ17_RS10525 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FSZ17_RS10530 ENOG4105CQB FAD linked oxidase domain protein FSZ17_RS10540 ENOG4105C8Q Methyl-accepting chemotaxis FSZ17_RS10560 ENOG4105VEQ Cold shock protein FSZ17_RS10570 ENOG4105EYH Exonuclease FSZ17_RS10585 ENOG4105EM7 Selenocysteine-specific translation elongation factor FSZ17_RS10590 ENOG41079KZ Major Facilitator Superfamily FSZ17_RS10595 ENOG4105DER m42 family FSZ17_RS10630 ENOG4105EJQ L-serine dehydratase FSZ17_RS10645 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FSZ17_RS10670 ENOG4105E39 Enoyl-CoA hydratase FSZ17_RS10675 ENOG4108UKI Enoyl-CoA hydratase FSZ17_RS10680 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FSZ17_RS10685 ENOG4105CHU acetyl-coa acetyltransferase FSZ17_RS10690 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FSZ17_RS10695 ENOG4105EA8 2-Nitropropane dioxygenase FSZ17_RS10705 ENOG4105C7J ABC transporter, permease FSZ17_RS10710 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FSZ17_RS10725 ENOG4107RUY (E1 component), alpha subunit FSZ17_RS10730 ENOG4105CPP Dehydrogenase, E1 component FSZ17_RS10745 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FSZ17_RS10750 ENOG4105CIH Imidazole acetol-phosphate transaminase FSZ17_RS10755 ENOG4107XWI flavin reductase domain protein, FMN-binding FSZ17_RS10760 ENOG4105ERH Fumarylacetoacetate hydrolase FSZ17_RS10770 ENOG4105EPR degv family FSZ17_RS10775 ENOG4105C5H ABC transporter FSZ17_RS10785 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FSZ17_RS10790 ENOG4105EXW epimerase dehydratase FSZ17_RS10795 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FSZ17_RS10815 ENOG41076DU acid-soluble spore protein P FSZ17_RS10825 ENOG410746C Acid-soluble spore protein O FSZ17_RS10830 ENOG4108I0Z Aconitate hydratase FSZ17_RS10840 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FSZ17_RS10855 ENOG41067CD Small, acid-soluble spore protein Tlp FSZ17_RS10860 ENOG4106F1P AAA ATPase, central domain protein FSZ17_RS10870 ENOG4105W8X HesB YadR YfhF-family protein FSZ17_RS10880 ENOG4105C8Q Methyl-accepting chemotaxis FSZ17_RS10885 ENOG4105PNM synthesis protein FSZ17_RS10890 ENOG4105BZU Histidine kinase FSZ17_RS10895 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FSZ17_RS10905 ENOG4105CPN adenine deaminase FSZ17_RS10910 ENOG4105C7N Xanthine uracil vitamin C permease FSZ17_RS10920 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family FSZ17_RS10925 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FSZ17_RS10935 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FSZ17_RS10960 ENOG4108RWI nicotinamidase FSZ17_RS10965 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FSZ17_RS10970 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FSZ17_RS10975 ENOG4105KNY Microcompartments protein FSZ17_RS10985 ENOG4105KNY Microcompartments protein FSZ17_RS10990 ENOG4105KNY Microcompartments protein FSZ17_RS11005 ENOG4105CPN adenine deaminase FSZ17_RS11010 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FSZ17_RS11015 ENOG4105EIG urea carboxylase-associated protein 1 FSZ17_RS11025 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FSZ17_RS11030 ENOG4105K4P CoA-binding domain protein FSZ17_RS11035 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FSZ17_RS11100 ENOG4105CJ1 ABC, transporter FSZ17_RS11120 ENOG4105QAX Iron-sulfur FSZ17_RS11125 ENOG4107QY8 reductase FSZ17_RS11195 ENOG4105DND Transcriptional regulator FSZ17_RS11205 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FSZ17_RS11215 ENOG4105SZ6 Thioredoxin FSZ17_RS11225 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FSZ17_RS11235 ENOG41069DP small acid-soluble spore protein FSZ17_RS11245 ENOG4105CI2 imidazolone-5-propionate hydrolase FSZ17_RS11275 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FSZ17_RS11295 ENOG4107VFR oxidoreductase FSZ17_RS11310 ENOG4105DPN Oligoendopeptidase f FSZ17_RS11325 ENOG41085PJ rdd domain containing protein FSZ17_RS11340 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FSZ17_RS11365 ENOG4107TYC hydantoinase B oxoprolinase FSZ17_RS11380 ENOG4105C26 Dehydrogenase FSZ17_RS11385 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FSZ17_RS11390 ENOG4108IQI permease FSZ17_RS11395 ENOG4105C1G acyl-Coa dehydrogenase FSZ17_RS11400 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FSZ17_RS11410 ENOG4105EWU Squalene--hopene cyclase FSZ17_RS11430 ENOG4105C7B Threonine dehydratase FSZ17_RS11440 ENOG4108HGU Histidine kinase FSZ17_RS11450 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FSZ17_RS11460 ENOG4105DWF phosphomethylpyrimidine kinase FSZ17_RS11475 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FSZ17_RS11485 ENOG4105ETU transcriptional activator (TenA FSZ17_RS11490 ENOG4105CM2 brancheD-chain amino acid aminotransferase FSZ17_RS11495 ENOG4108S01 response regulator FSZ17_RS11500 ENOG4108ZGX Histidine kinase FSZ17_RS11505 ENOG4105ECK Fatty Acid Desaturase FSZ17_RS11515 ENOG4105PTM secreted protein FSZ17_RS11525 ENOG4105ECY inositol monophosphatase FSZ17_RS11535 ENOG4108XHQ (2Fe-2S)-binding domain protein FSZ17_RS11555 ENOG4108YYC ycei family FSZ17_RS11560 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FSZ17_RS11575 ENOG4108VCA G U mismatch-specific DNA glycosylase FSZ17_RS11585 ENOG4107ZE5 PPIases accelerate the folding of proteins FSZ17_RS11600 ENOG4105BZ4 penicillin-binding protein FSZ17_RS11605 ENOG4105VRS hydrolase family 18 FSZ17_RS11610 ENOG4106FN3 tellurium resistance protein FSZ17_RS11615 ENOG4106FN3 tellurium resistance protein FSZ17_RS11620 ENOG4105BZU Histidine kinase FSZ17_RS11640 ENOG4105D8G Major Facilitator superfamily FSZ17_RS11650 ENOG4105CJ1 ABC, transporter FSZ17_RS11660 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FSZ17_RS11680 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FSZ17_RS11685 ENOG4108BGM Quinol dehydrogenase periplasmic component FSZ17_RS11690 ENOG4105C26 Dehydrogenase FSZ17_RS11700 ENOG4105C5H ABC transporter FSZ17_RS11715 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FSZ17_RS11720 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FSZ17_RS11725 ENOG4105E0C molybdate abc transporter FSZ17_RS11730 ENOG4105DZ1 carboxypeptidase FSZ17_RS11745 ENOG4105C4K Nad synthetase FSZ17_RS11750 ENOG4105DAP Nicotinate phosphoribosyltransferase FSZ17_RS11775 ENOG4105CA9 Pyruvate kinase FSZ17_RS11785 ENOG4105CEY Amp-dependent synthetase and ligase FSZ17_RS11805 ENOG4107RF6 penicillin-binding protein FSZ17_RS11810 ENOG4105C7S Dehydrogenase FSZ17_RS11820 ENOG4105C28 cystathionine FSZ17_RS11825 ENOG4105C28 cystathionine FSZ17_RS11845 ENOG4108Z18 K06886 hemoglobin FSZ17_RS11870 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FSZ17_RS11875 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FSZ17_RS11880 ENOG4105PXI polysaccharide deacetylase FSZ17_RS11885 ENOG4108HM4 ABC transporter FSZ17_RS11890 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component FSZ17_RS11895 ENOG4105F38 ABC transporter, permease FSZ17_RS11905 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FSZ17_RS11910 ENOG4105E1F short-chain dehydrogenase reductase FSZ17_RS11920 ENOG4106F5Q Membrane FSZ17_RS11930 ENOG4105J37 FSZ17_RS11935 ENOG4108AEY RNA polymerase sigma factor FSZ17_RS11945 ENOG4105BZ1 (ABC) transporter FSZ17_RS11970 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FSZ17_RS11985 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FSZ17_RS12060 ENOG4105C0R drug resistance transporter emrb qaca subfamily FSZ17_RS12065 ENOG4107RSM transcriptional regulator FSZ17_RS12080 ENOG4108W0I acetyltransferase FSZ17_RS12100 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FSZ17_RS12120 ENOG4105KGF protein, YerC YecD FSZ17_RS12140 ENOG4105DG4 malate L-lactate dehydrogenase FSZ17_RS12155 ENOG4108WYP Transcriptional regulator FSZ17_RS12165 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FSZ17_RS12175 ENOG4105D7N magnesium and cobalt transport protein CorA FSZ17_RS12205 ENOG4105EC8 Methyl-accepting chemotaxis FSZ17_RS12215 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FSZ17_RS12220 ENOG41080TC multidrug resistance protein FSZ17_RS12230 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FSZ17_RS12235 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FSZ17_RS12240 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FSZ17_RS12255 ENOG4105CGK Exodeoxyribonuclease III FSZ17_RS12265 ENOG4108X3M OsmC Ohr family protein FSZ17_RS12275 ENOG4108NFJ ABC transporter FSZ17_RS12290 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FSZ17_RS12300 ENOG4108JU6 CBS domain protein FSZ17_RS12310 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FSZ17_RS12325 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FSZ17_RS12330 ENOG4105F22 Major Facilitator Superfamily FSZ17_RS12335 ENOG4105DEN Luciferase family FSZ17_RS12350 ENOG4108UT2 hemolysin iii FSZ17_RS12360 ENOG4105C26 Dehydrogenase FSZ17_RS12380 ENOG4107S9D Alpha beta hydrolase FSZ17_RS12445 ENOG4107Y2X deaminase FSZ17_RS12450 ENOG4105CHH sulfate transporter FSZ17_RS12460 ENOG4105CZM Major Facilitator FSZ17_RS12470 ENOG4105CN5 Metallo-Beta-Lactamase FSZ17_RS12490 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FSZ17_RS12530 ENOG4105VZ8 Transcriptional regulator FSZ17_RS12550 ENOG4105PAD Hydrolase FSZ17_RS12580 ENOG4108KPJ rna polymerase sigma factor FSZ17_RS12590 ENOG4105CHM Aminotransferase FSZ17_RS12595 ENOG4108ZB6 transcriptional regulator AsnC family FSZ17_RS12630 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FSZ17_RS12640 ENOG4105CHJ isochorismatase hydrolase FSZ17_RS12645 ENOG4105DND Transcriptional regulator FSZ17_RS12680 ENOG4105KVH Transcriptional regulator FSZ17_RS12695 ENOG4105DRS transport system, permease FSZ17_RS12700 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FSZ17_RS12715 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FSZ17_RS12720 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FSZ17_RS12740 ENOG4105PGS Spore coat protein FSZ17_RS12790 ENOG4105CNG UPF0061 protein FSZ17_RS12800 ENOG4105IJJ transcriptional regulator, crp fnr family FSZ17_RS12805 ENOG4107EPV Aminotransferase class V FSZ17_RS12815 ENOG4105MWK D-amino acid dehydrogenase, small subunit FSZ17_RS12820 ENOG4108JQ7 (ABC) transporter FSZ17_RS12825 ENOG4105C3U ABC transporter FSZ17_RS12830 ENOG4105DC7 peptidase M24 FSZ17_RS12835 ENOG4105DEF Extracellular solute-binding protein, family 5 FSZ17_RS12840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSZ17_RS12850 ENOG4105DC7 peptidase M24 FSZ17_RS12855 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FSZ17_RS12865 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FSZ17_RS12880 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FSZ17_RS12930 ENOG4105CNN ABC, transporter FSZ17_RS12935 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FSZ17_RS12940 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FSZ17_RS12945 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FSZ17_RS12955 ENOG41087PP glycosyltransferase MGT family FSZ17_RS12985 ENOG4105M6F mutator MutT protein FSZ17_RS13010 ENOG4107S6Z Na H antiporter FSZ17_RS13040 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FSZ17_RS13075 ENOG4105KNA -acetyltransferase FSZ17_RS13170 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) FSZ17_RS13195 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FSZ17_RS13200 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FSZ17_RS13205 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) FSZ17_RS13210 ENOG4105KNY Microcompartments protein FSZ17_RS13215 ENOG4105KNY Microcompartments protein FSZ17_RS13225 ENOG4105KNY Microcompartments protein FSZ17_RS13235 ENOG4108EKI Dehydrogenase FSZ17_RS13240 ENOG4105FB2 class II Aldolase FSZ17_RS13250 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FSZ17_RS13260 ENOG4105CNN ABC, transporter FSZ17_RS13265 ENOG4105C2J ABC transporter FSZ17_RS13280 ENOG4105C8Q Methyl-accepting chemotaxis FSZ17_RS13290 ENOG4105CPI Metal Dependent Phosphohydrolase FSZ17_RS13300 ENOG4105EEM helicase FSZ17_RS13315 ENOG4107RT3 EamA-like transporter family FSZ17_RS13320 ENOG4105SX7 Transporter FSZ17_RS13340 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FSZ17_RS13350 ENOG4105C0H protease FSZ17_RS13405 ENOG4108W8W CRISPR-associated RAMP protein, Csm3 family FSZ17_RS13420 ENOG4105DTQ mandelate racemase muconate lactonizing FSZ17_RS13425 ENOG4107V0Z fmn reductase FSZ17_RS13435 ENOG4106TD9 Diguanylate cyclase FSZ17_RS13440 ENOG4105CPI Metal Dependent Phosphohydrolase FSZ17_RS13475 ENOG4108J2R molybdopterin oxidoreductase FSZ17_RS13480 ENOG4107TS3 membrane protein, TerC FSZ17_RS13485 ENOG4105BZU Histidine kinase FSZ17_RS13490 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FSZ17_RS13505 ENOG4105EKQ RNA-directed DNA polymerase FSZ17_RS13530 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FSZ17_RS13540 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FSZ17_RS13545 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FSZ17_RS13550 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FSZ17_RS13555 ENOG4105DRR Transcriptional regulator, GntR family FSZ17_RS13560 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FSZ17_RS13570 ENOG4105X3H Excalibur domain protein FSZ17_RS13575 ENOG4105JVQ RNA Polymerase FSZ17_RS13585 ENOG4105DVE abc transporter atp-binding protein FSZ17_RS13590 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FSZ17_RS13595 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FSZ17_RS13600 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FSZ17_RS13605 ENOG4105J4Q Transcriptional regulator FSZ17_RS13610 ENOG4105C82 Malate synthase FSZ17_RS13615 ENOG4105Z8B NlpC/P60 family FSZ17_RS13625 ENOG4108QY0 Membrane FSZ17_RS13650 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FSZ17_RS13660 ENOG4105DWK Membrane FSZ17_RS13705 ENOG4105DK0 Indole-3-glycerol phosphate synthase FSZ17_RS13715 ENOG4105DDQ anthranilate synthase FSZ17_RS13720 ENOG4105CRQ synthase (Component I) FSZ17_RS13725 ENOG4108RPX mosc domain containing protein FSZ17_RS13740 ENOG4107VMI polysaccharide deacetylase FSZ17_RS13745 ENOG4105C7Z Conserved Protein FSZ17_RS13750 ENOG4105C6Z Gluconate FSZ17_RS13755 ENOG4105BZW Glycerate kinase FSZ17_RS13760 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FSZ17_RS13765 ENOG4105CE1 Ferrous iron transport protein b FSZ17_RS13770 ENOG4105CE1 Ferrous iron transport protein b FSZ17_RS13785 ENOG4105E1K spore germination protein FSZ17_RS13790 ENOG4108Q8B Spore germination protein FSZ17_RS13800 ENOG4105WMR Protein CrcB homolog FSZ17_RS13805 ENOG4105WMR Protein CrcB homolog FSZ17_RS13840 ENOG4105CMR udp-glucose 4-epimerase FSZ17_RS13865 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FSZ17_RS13870 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FSZ17_RS13880 ENOG4105C01 Dihydroxy-acid dehydratase FSZ17_RS13895 ENOG4108J59 Extracellular solute-binding protein, family 5 FSZ17_RS13910 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FSZ17_RS13915 ENOG4105BZU Histidine kinase FSZ17_RS13925 ENOG4106GRI small acid-soluble spore protein H FSZ17_RS13950 ENOG4105VEQ Cold shock protein FSZ17_RS13955 ENOG4105C1J atp-dependent rna helicase FSZ17_RS13960 ENOG4105VEQ Cold shock protein FSZ17_RS13970 ENOG410756H nucleotidyltransferase FSZ17_RS13975 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FSZ17_RS13985 ENOG4105FDF Could be involved in DNA repair (By similarity) FSZ17_RS13990 ENOG4105DQE DNA ligase FSZ17_RS13995 ENOG4105D58 Diguanylate phosphodiesterase FSZ17_RS14000 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FSZ17_RS14005 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FSZ17_RS14010 ENOG4108R6K riboflavin synthase, subunit alpha FSZ17_RS14015 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FSZ17_RS14020 ENOG4105EU9 FSZ17_RS14025 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FSZ17_RS14045 ENOG4105DA5 (ABC) transporter FSZ17_RS14050 ENOG41069JR FSZ17_RS14065 ENOG4107T5V SNARE associated Golgi FSZ17_RS14070 ENOG4105CPN adenine deaminase FSZ17_RS14085 ENOG4107QMU Mate efflux family protein FSZ17_RS14100 ENOG4105K4I Scp-like extracellular FSZ17_RS14105 ENOG4105BZU Histidine kinase FSZ17_RS14110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FSZ17_RS14135 ENOG4105CKI cobalamin synthesis protein FSZ17_RS14150 ENOG4108VXD carboxy-peptidase FSZ17_RS14160 ENOG4106Z5R FSZ17_RS14165 ENOG4108N23 SpoOM-related protein FSZ17_RS14170 ENOG4105C5I Dehydrogenase FSZ17_RS14195 ENOG4107T5V SNARE associated Golgi FSZ17_RS14200 ENOG410841Q phosphoesterase PA-phosphatase related protein FSZ17_RS14205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FSZ17_RS14210 ENOG4105BZU Histidine kinase FSZ17_RS14230 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FSZ17_RS14235 ENOG4108JUB Transcriptional regulator FSZ17_RS14240 ENOG4108TSC N-acetyltransferase FSZ17_RS14245 ENOG4107S4Y M20 DapE family protein YgeY FSZ17_RS14260 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FSZ17_RS14290 ENOG41090WU lipolytic protein G-D-S-L family FSZ17_RS14295 ENOG4108KF3 Electron transport protein SCO1 SenC FSZ17_RS14300 ENOG4105BZU Histidine kinase FSZ17_RS14310 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FSZ17_RS14315 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FSZ17_RS14320 ENOG4105C7B Threonine dehydratase FSZ17_RS14330 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FSZ17_RS14345 ENOG4108N0M stress protein FSZ17_RS14355 ENOG4108TTB tellurium resistance protein FSZ17_RS14385 ENOG4107TS3 membrane protein, TerC FSZ17_RS14390 ENOG4106FN3 tellurium resistance protein FSZ17_RS14400 ENOG4105CHM Aminotransferase FSZ17_RS14410 ENOG4107YX5 Pfam:DUF548 FSZ17_RS14415 ENOG4108Y6J UPF0403 protein FSZ17_RS14430 ENOG4105C5H ABC transporter FSZ17_RS14440 ENOG4108D32 Methyltransferase FSZ17_RS14460 ENOG4108RCR degv family FSZ17_RS14505 ENOG4105CVG Homoserine O-transsuccinylase FSZ17_RS14525 ENOG4105KST dependent repressor FSZ17_RS14535 ENOG4105CS1 NAD(P)H quinone oxidoreductase FSZ17_RS14540 ENOG4105FBA Phospholipase Carboxylesterase FSZ17_RS14545 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FSZ17_RS14570 ENOG41081VK Ribonuclease FSZ17_RS14600 ENOG4105KHC sulfurtransferase FSZ17_RS14610 ENOG410890F Dynamin family FSZ17_RS14620 ENOG41065KQ synthase FSZ17_RS14650 ENOG4105NAA Cytochrome C oxidase, subunit II FSZ17_RS14655 ENOG4107RQ2 Cytochrome c oxidase, subunit I FSZ17_RS14665 ENOG4105CTD carboxy-peptidase FSZ17_RS14675 ENOG4105DVT helicase FSZ17_RS14680 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FSZ17_RS14685 ENOG4105BZU Histidine kinase FSZ17_RS14695 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FSZ17_RS14700 ENOG4106F55 Protein of unknown function (DUF1273) FSZ17_RS14710 ENOG4107X2U Inherit from COG: Exonuclease-like protein FSZ17_RS14715 ENOG4108I5C dEAD DEAH box helicase FSZ17_RS14720 ENOG4105IJJ transcriptional regulator, crp fnr family FSZ17_RS14725 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FSZ17_RS14730 ENOG4107Y70 Heat shock protein FSZ17_RS14735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSZ17_RS14740 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FSZ17_RS14775 ENOG4105BZ4 penicillin-binding protein FSZ17_RS14785 ENOG4105CSM endonuclease III FSZ17_RS14795 ENOG4105C5S asparaginyl-tRNA synthetase FSZ17_RS14810 ENOG4105YAC FSZ17_RS14815 ENOG4105DVT helicase FSZ17_RS14820 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FSZ17_RS14825 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FSZ17_RS14845 ENOG4105CPK Glycosyl transferase (Group 1 FSZ17_RS14850 ENOG4105FJR Lmbe family FSZ17_RS14855 ENOG4108Z5K methylglyoxal synthase FSZ17_RS14860 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FSZ17_RS14865 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FSZ17_RS14870 ENOG4108JYZ YitT family FSZ17_RS14890 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FSZ17_RS14895 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FSZ17_RS14900 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FSZ17_RS14915 ENOG41068YB TPR repeat-containing protein FSZ17_RS14925 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FSZ17_RS14935 ENOG4105CIH Imidazole acetol-phosphate transaminase FSZ17_RS14940 ENOG4105KHN chorismate mutase FSZ17_RS14945 ENOG4105D49 3-dehydroquinate synthase FSZ17_RS14950 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FSZ17_RS14955 ENOG4105BZU Histidine kinase FSZ17_RS14960 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FSZ17_RS14965 ENOG4105EAH synthase FSZ17_RS14970 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FSZ17_RS14975 ENOG4105XXQ heptaprenyl diphosphate synthase component I FSZ17_RS14985 ENOG4105EUJ GTP cyclohydrolase i FSZ17_RS14990 ENOG4105K70 DNA-binding protein FSZ17_RS14995 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FSZ17_RS15010 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FSZ17_RS15015 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FSZ17_RS15030 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FSZ17_RS15035 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FSZ17_RS15045 ENOG4105CAT Cytidine monophosphate kinase FSZ17_RS15060 ENOG4105MSI germination protein ypeb FSZ17_RS15065 ENOG4105F0V Cell wall hydrolase FSZ17_RS15075 ENOG4107RB3 L-asparaginase FSZ17_RS15080 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FSZ17_RS15095 ENOG4107RGJ metallophosphoesterase FSZ17_RS15120 ENOG4105WEF catalase FSZ17_RS15135 ENOG4105I7S Abortive infection protein FSZ17_RS15140 ENOG4105C9U ATP-dependent DNA helicase RecQ FSZ17_RS15145 ENOG4105T7X FSZ17_RS15155 ENOG4108SAX Membrane FSZ17_RS15170 ENOG4105BZU Histidine kinase FSZ17_RS15175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FSZ17_RS15180 ENOG4105CRE cytochrome C FSZ17_RS15185 ENOG4107TWT Cytochrome c biogenesis protein FSZ17_RS15190 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FSZ17_RS15195 ENOG4105FE9 pseudouridine synthase FSZ17_RS15205 ENOG4108JIC nucleoside recognition domain protein FSZ17_RS15210 ENOG4105DZ1 carboxypeptidase FSZ17_RS15215 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FSZ17_RS15230 ENOG4105DA5 (ABC) transporter FSZ17_RS15250 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FSZ17_RS15255 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FSZ17_RS15285 ENOG4105G6R Stage v sporulation protein ae FSZ17_RS15300 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FSZ17_RS15305 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FSZ17_RS15310 ENOG41082AN stage II sporulation protein FSZ17_RS15315 ENOG4105DZ1 carboxypeptidase FSZ17_RS15335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FSZ17_RS15350 ENOG4105I3K Ferric uptake regulator, Fur family FSZ17_RS15355 ENOG4105MZ9 stage II sporulation protein m FSZ17_RS15380 ENOG4105CPC Aldo Keto reductase FSZ17_RS15395 ENOG4108IIH CoA-transferase subunit B FSZ17_RS15400 ENOG4105D6N CoA-transferase, subunit a FSZ17_RS15405 ENOG4105CHU acetyl-coa acetyltransferase FSZ17_RS15410 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FSZ17_RS15430 ENOG4105EMN RNA polymerase sigma factor FSZ17_RS15435 ENOG4106HZJ FSZ17_RS15450 ENOG4107TVP HD domain protein FSZ17_RS15460 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FSZ17_RS15470 ENOG4108IXY short-chain dehydrogenase reductase FSZ17_RS15475 ENOG41069FQ Metallo-beta-lactamase superfamily FSZ17_RS15480 ENOG4108KGH TRANSCRIPTIONal FSZ17_RS15485 ENOG4108RAV Conserved protein FSZ17_RS15490 ENOG4108K8S endonuclease I FSZ17_RS15495 ENOG4105II7 pyrroline-5-carboxylate reductase FSZ17_RS15510 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FSZ17_RS15515 ENOG4105C8J )-transporter FSZ17_RS15525 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FSZ17_RS15530 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FSZ17_RS15535 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FSZ17_RS15540 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FSZ17_RS15545 ENOG4105YFD chemotaxis, protein FSZ17_RS15550 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FSZ17_RS15555 ENOG4108HNZ carboxyl transferase FSZ17_RS15560 ENOG4108ZVT methylmalonyl-coA epimerase FSZ17_RS15565 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FSZ17_RS15570 ENOG4108QEG Membrane FSZ17_RS15575 ENOG4105CDA abc transporter atp-binding protein FSZ17_RS15580 ENOG4105E5Q amino acid AbC transporter FSZ17_RS15585 ENOG4108HW3 (ABC) transporter FSZ17_RS15590 ENOG4108Y6J UPF0403 protein FSZ17_RS15595 ENOG4105DJT lAO AO transport system ATPase FSZ17_RS15600 ENOG4105D5P Methylmalonyl-coA mutase FSZ17_RS15605 ENOG4105CMN Methylmalonyl-coA mutase FSZ17_RS15610 ENOG4105C7S Dehydrogenase FSZ17_RS15615 ENOG4105CPP Dehydrogenase, E1 component FSZ17_RS15635 ENOG4107RDP Dehydrogenase FSZ17_RS15645 ENOG4108JUB Transcriptional regulator FSZ17_RS15650 ENOG4106CCJ Protein of unknown function (DUF2627) FSZ17_RS15655 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FSZ17_RS15665 ENOG4107QQR Sporulation FSZ17_RS15670 ENOG4105S1Z Stage IV sporulation protein B FSZ17_RS15675 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FSZ17_RS15685 ENOG4105DX0 Hemolysin A FSZ17_RS15690 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FSZ17_RS15700 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FSZ17_RS15705 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FSZ17_RS15715 ENOG4105M7K Involved in the transcription termination process (By similarity) FSZ17_RS15720 ENOG4108ZSR alkaline shock protein FSZ17_RS15725 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FSZ17_RS15745 ENOG410644B Stage III sporulation protein af FSZ17_RS15755 ENOG4105KQ4 Stage iii sporulation protein ad FSZ17_RS15760 ENOG4108CQH stage III sporulation protein AC FSZ17_RS15765 ENOG4105KR5 Stage iii sporulation protein FSZ17_RS15770 ENOG4105CD2 stage iii sporulation protein aa FSZ17_RS15785 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FSZ17_RS15790 ENOG4105CZM Major Facilitator FSZ17_RS15815 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FSZ17_RS15820 ENOG4105DC7 peptidase M24 FSZ17_RS15830 ENOG4105CBJ Metal-dependent enzyme FSZ17_RS15845 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FSZ17_RS15850 ENOG4105TRT Transcriptional regulator FSZ17_RS15855 ENOG4108IJ7 Glycine betaine FSZ17_RS15860 ENOG4107SQ8 Glycine betaine FSZ17_RS15875 ENOG4105BZU Histidine kinase FSZ17_RS15880 ENOG4105KCT ABC transporter FSZ17_RS15885 ENOG4108M15 ABC transporter FSZ17_RS15895 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FSZ17_RS15900 ENOG4105WZW rhodanese family FSZ17_RS15910 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FSZ17_RS15915 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FSZ17_RS15920 ENOG4105C0D helicase FSZ17_RS15955 ENOG4106855 Competence protein FSZ17_RS15985 ENOG4105C5X domain protein FSZ17_RS16005 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FSZ17_RS16015 ENOG4105E0M Sulfatase FSZ17_RS16025 ENOG4107ZXI Rhomboid family FSZ17_RS16040 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FSZ17_RS16070 ENOG4108UTW Plays a role in the regulation of phosphate uptake FSZ17_RS16075 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FSZ17_RS16080 ENOG4105E2Z phosphate ABC transporter (Permease FSZ17_RS16085 ENOG4105C8U phosphate abc transporter FSZ17_RS16090 ENOG4105CVA phosphate FSZ17_RS16095 ENOG4107RF6 penicillin-binding protein FSZ17_RS16110 ENOG4105SXS Protein of unknown function (DUF456) FSZ17_RS16135 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FSZ17_RS16140 ENOG41063Y9 FSZ17_RS16145 ENOG4108U5J '-nucleotidase FSZ17_RS16150 ENOG4105N80 Ferric uptake regulator, Fur family FSZ17_RS16155 ENOG4105FAV ABC, transporter FSZ17_RS16160 ENOG4105FDK ABC transporter FSZ17_RS16165 ENOG41069ZM Protein of unknown function (DUF2624) FSZ17_RS16170 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FSZ17_RS16185 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FSZ17_RS16190 ENOG4105EGD dinuclear metal center protein, YbgI family FSZ17_RS16210 ENOG4105C1G acyl-Coa dehydrogenase FSZ17_RS16220 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FSZ17_RS16225 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FSZ17_RS16245 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FSZ17_RS16250 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FSZ17_RS16255 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FSZ17_RS16265 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FSZ17_RS16270 ENOG4105KG3 cytidine deaminase FSZ17_RS16275 ENOG4107YR5 Diacylglycerol kinase FSZ17_RS16285 ENOG4105CTJ Metal Dependent Phosphohydrolase FSZ17_RS16290 ENOG4105C9A Phoh family FSZ17_RS16300 ENOG41068P3 sporulation protein YqfC FSZ17_RS16310 ENOG4105DI5 UPF0365 protein FSZ17_RS16315 ENOG4105F7J membrane-bound serine protease FSZ17_RS16320 ENOG4105KTH gatB Yqey FSZ17_RS16325 ENOG4105VCC 30S ribosomal protein S21 FSZ17_RS16335 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FSZ17_RS16340 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FSZ17_RS16345 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FSZ17_RS16350 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FSZ17_RS16355 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FSZ17_RS16360 ENOG4105CFG Acts as a chaperone (By similarity) FSZ17_RS16365 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FSZ17_RS16375 ENOG4105CSA Coproporphyrinogen iii oxidase FSZ17_RS16380 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FSZ17_RS16390 ENOG4108ZRV stage ii sporulation protein p FSZ17_RS16395 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) FSZ17_RS16400 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FSZ17_RS16405 ENOG4105TQK DNA polymerase iii, delta' subunit FSZ17_RS16415 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FSZ17_RS16425 ENOG4105KQC Competence protein FSZ17_RS16435 ENOG4105DXX methyltransferase FSZ17_RS16445 ENOG4108WF2 Metal Dependent Phosphohydrolase FSZ17_RS16450 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FSZ17_RS16455 ENOG410812S Rna-binding protein FSZ17_RS16465 ENOG4105CQW ribosome biogenesis GTPase YqeH FSZ17_RS16470 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FSZ17_RS16480 ENOG4105DJ4 phosphatidylserine decarboxylase FSZ17_RS16485 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FSZ17_RS16500 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FSZ17_RS16510 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FSZ17_RS16525 ENOG4107XRG penicillin-binding protein FSZ17_RS16530 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FSZ17_RS16535 ENOG4105DBI uridine monophosphokinase FSZ17_RS16540 ENOG4105CFP Peptidase U32 FSZ17_RS16545 ENOG4105XYU peptidase (U32 family) FSZ17_RS16555 ENOG4105HHA aminodeoxychorismate lyase FSZ17_RS16560 ENOG4105VPH UPF0473 protein FSZ17_RS16565 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FSZ17_RS16570 ENOG4105VBH UPF0297 protein FSZ17_RS16580 ENOG4105C02 permease FSZ17_RS16585 ENOG41060CR FSZ17_RS16595 ENOG4105C7H Helicase, RecD TraA family FSZ17_RS16605 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FSZ17_RS16610 ENOG4105C3J Cysteine desulfurase FSZ17_RS16625 ENOG4105D1H recombination factor protein RarA FSZ17_RS16630 ENOG4108TU7 Inherit from COG: (ABC) transporter FSZ17_RS16635 ENOG4105CJ1 ABC, transporter FSZ17_RS16640 ENOG4105CZV ABC transporter FSZ17_RS16645 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FSZ17_RS16655 ENOG4105CUZ uba thif-type nad fad binding protein FSZ17_RS16665 ENOG4105C9M aspartyl-trna synthetase FSZ17_RS16670 ENOG4105CUT histidyl-tRNA synthetase FSZ17_RS16675 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FSZ17_RS16680 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FSZ17_RS16685 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FSZ17_RS16690 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FSZ17_RS16695 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FSZ17_RS16700 ENOG41076HS cation diffusion facilitator family transporter FSZ17_RS16705 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FSZ17_RS16715 ENOG4105CKP Polysaccharide Biosynthesis Protein FSZ17_RS16720 ENOG4108QG2 Membrane FSZ17_RS16725 ENOG4105NAP FSZ17_RS16730 ENOG4105VIE preprotein translocase, subunit YajC FSZ17_RS16740 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FSZ17_RS16750 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FSZ17_RS16765 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FSZ17_RS16770 ENOG4105FF2 Type I DHQase FSZ17_RS16780 ENOG4105CJ1 ABC, transporter FSZ17_RS16785 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FSZ17_RS16810 ENOG4105CQC Prephenate dehydratase FSZ17_RS16815 ENOG41090I5 UPF0735 ACT domain-containing protein FSZ17_RS16820 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FSZ17_RS16830 ENOG4105K46 50S ribosomal protein l27 FSZ17_RS16835 ENOG4105X36 (ribosomal) protein FSZ17_RS16840 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FSZ17_RS16845 ENOG4105C03 ribonuclease FSZ17_RS16860 ENOG4107QMS site-determining protein FSZ17_RS16865 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FSZ17_RS16870 ENOG4105YHC Rod shape-determining protein MreD FSZ17_RS16875 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FSZ17_RS16880 ENOG4105DFF Rod shape-determining protein mreb FSZ17_RS16885 ENOG4105W5Q DNA repair protein (RadC FSZ17_RS16890 ENOG4108Z03 MAF-like protein FSZ17_RS16915 ENOG4106A3R peptidase FSZ17_RS16920 ENOG4105X0D Fimbrial protein FSZ17_RS16925 ENOG4105D7Q type ii secretion system FSZ17_RS16930 ENOG4105CZX twitching motility protein FSZ17_RS16935 ENOG4107QHF type ii secretion system protein e FSZ17_RS16965 ENOG4105BZU Histidine kinase FSZ17_RS16970 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FSZ17_RS16975 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FSZ17_RS16985 ENOG4106AR7 Spore coat protein FSZ17_RS16990 ENOG41068KH stage VI sporulation protein D FSZ17_RS16990 ENOG41068KH stage VI sporulation protein D FSZ17_RS16995 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FSZ17_RS17000 ENOG4105D52 delta-aminolevulinic acid dehydratase FSZ17_RS17010 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FSZ17_RS17020 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FSZ17_RS17030 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FSZ17_RS17035 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FSZ17_RS17040 ENOG4108IUQ atp-dependent protease FSZ17_RS17045 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FSZ17_RS17050 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FSZ17_RS17060 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FSZ17_RS17065 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FSZ17_RS17070 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FSZ17_RS17075 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FSZ17_RS17080 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FSZ17_RS17085 ENOG4108ZP8 Acetolactate synthase small subunit FSZ17_RS17090 ENOG4105C7K acetolactate synthase FSZ17_RS17100 ENOG4105M59 Phosphodiesterase, mj0936 family FSZ17_RS17115 ENOG4108XJQ germination protein FSZ17_RS17120 ENOG4105C9U ATP-dependent DNA helicase RecQ FSZ17_RS17130 ENOG41067TZ transcriptional regulator, MarR family FSZ17_RS17135 ENOG4105PFC Transcriptional regulator FSZ17_RS17145 ENOG4105E33 succinate dehydrogenase FSZ17_RS17155 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FSZ17_RS17170 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FSZ17_RS17175 ENOG4105K63 Thioredoxin FSZ17_RS17180 ENOG4105C10 Electron transfer flavoprotein FSZ17_RS17185 ENOG4105BZJ Electron transfer flavoprotein FSZ17_RS17190 ENOG41060WC Enoyl-CoA hydratase FSZ17_RS17195 ENOG4107Z3H Transcriptional regulator, TetR family FSZ17_RS17200 ENOG4105CEY Amp-dependent synthetase and ligase FSZ17_RS17210 ENOG4105C98 muts2 protein FSZ17_RS17215 ENOG4105DCG PHP domain protein FSZ17_RS17225 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FSZ17_RS17230 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FSZ17_RS17235 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FSZ17_RS17240 ENOG4108J2R molybdopterin oxidoreductase FSZ17_RS17245 ENOG4105G9B Transcriptional regulator FSZ17_RS17260 ENOG4105C3J Cysteine desulfurase FSZ17_RS17265 ENOG4105QAX Iron-sulfur FSZ17_RS17280 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FSZ17_RS17285 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FSZ17_RS17290 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FSZ17_RS17295 ENOG4108RWN rrna methyltransferase FSZ17_RS17305 ENOG4105CN9 Peptidase m42 family protein FSZ17_RS17310 ENOG4105DUM transcriptional regulator, lysR family FSZ17_RS17335 ENOG410696E Membrane FSZ17_RS17340 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FSZ17_RS17345 ENOG4105VJV 50s ribosomal protein L35 FSZ17_RS17350 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FSZ17_RS17355 ENOG4105C22 threonyL-tRNA synthetase FSZ17_RS17360 ENOG4108TDW sporulation protein YtxC FSZ17_RS17375 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FSZ17_RS17380 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FSZ17_RS17385 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FSZ17_RS17390 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FSZ17_RS17400 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FSZ17_RS17405 ENOG4105C2M dna polymerase I FSZ17_RS17410 ENOG4105EPW hflc protein FSZ17_RS17415 ENOG4107QJR hflk protein FSZ17_RS17420 ENOG4105BZU Histidine kinase FSZ17_RS17425 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FSZ17_RS17435 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FSZ17_RS17440 ENOG4108HMX isocitrate dehydrogenase (NADP) FSZ17_RS17445 ENOG4105BZN citrate synthase FSZ17_RS17450 ENOG4108VMM UPF0756 membrane protein FSZ17_RS17455 ENOG4108REF Sporulation integral membrane protein ytvi FSZ17_RS17460 ENOG4105FS0 cytoplasmic membrane protein FSZ17_RS17465 ENOG4105CA9 Pyruvate kinase FSZ17_RS17470 ENOG4105CTQ phosphohexokinase FSZ17_RS17475 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FSZ17_RS17485 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FSZ17_RS17490 ENOG4105C6K Malic enzyme FSZ17_RS17495 ENOG4105C0B DNA polymerase III (alpha subunit) FSZ17_RS17500 ENOG4105VV2 FSZ17_RS17510 ENOG4105SFS phosphoesterase RecJ domain protein FSZ17_RS17530 ENOG4105E8R UPF0173 metal-dependent hydrolase FSZ17_RS17535 ENOG4105DC7 peptidase M24 FSZ17_RS17540 ENOG4107YZX Universal stress protein FSZ17_RS17550 ENOG41081VB Hydrolase FSZ17_RS17560 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FSZ17_RS17575 ENOG4105F32 YngK protein FSZ17_RS17580 ENOG4105CH7 arginosuccinase FSZ17_RS17585 ENOG4105CDH Citrulline--aspartate ligase FSZ17_RS17600 ENOG4105EPU Molybdenum cofactor synthesis domain protein FSZ17_RS17610 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FSZ17_RS17620 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FSZ17_RS17625 ENOG4105KBJ sporulation protein ytfj FSZ17_RS17635 ENOG4105VK3 rdd domain containing protein FSZ17_RS17640 ENOG4105D07 Signal peptide peptidase, SppA FSZ17_RS17645 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FSZ17_RS17655 ENOG4105FR1 rard protein FSZ17_RS17660 ENOG4105EFZ amidohydrolase FSZ17_RS17665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FSZ17_RS17675 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FSZ17_RS17690 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) FSZ17_RS17695 ENOG4108W76 histidinol phosphate phosphatase hisj family FSZ17_RS17700 ENOG4105U5Y Transcriptional regulator FSZ17_RS17710 ENOG4105C28 cystathionine FSZ17_RS17715 ENOG4105BZU Histidine kinase FSZ17_RS17725 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FSZ17_RS17735 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FSZ17_RS17755 ENOG4105F1V Acetoin utilization protein FSZ17_RS17760 ENOG4105W87 Cbs domain FSZ17_RS17765 ENOG4105DGU Histone deacetylase FSZ17_RS17770 ENOG4106VK6 Flagellar motor protein FSZ17_RS17775 ENOG4105E14 MotA TolQ exbB proton channel FSZ17_RS17780 ENOG4105ETE Transcriptional regulator (LacI family FSZ17_RS17785 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FSZ17_RS17790 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FSZ17_RS17810 ENOG4105C88 aminopeptidase FSZ17_RS17815 ENOG4105DFU Cell wall formation (By similarity) FSZ17_RS17830 ENOG4108NKM UPF0354 protein FSZ17_RS17860 ENOG4105C26 Dehydrogenase FSZ17_RS17870 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FSZ17_RS17885 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FSZ17_RS17890 ENOG4105E39 Enoyl-CoA hydratase FSZ17_RS17900 ENOG4105E39 Enoyl-CoA hydratase FSZ17_RS17905 ENOG4108JUB Transcriptional regulator FSZ17_RS17915 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FSZ17_RS17925 ENOG4108V15 phosphotransferase enzyme family FSZ17_RS17930 ENOG4108IUM Glycogen debranching enzyme FSZ17_RS17945 ENOG4107F58 2'-5' rna ligase FSZ17_RS17955 ENOG4105BZU Histidine kinase FSZ17_RS17960 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FSZ17_RS17970 ENOG4107QSE Dipeptidase FSZ17_RS17990 ENOG4105YW5 deoR family transcriptional regulator FSZ17_RS18020 ENOG4107XUC SirA family FSZ17_RS18025 ENOG4105CBX hi0933 family FSZ17_RS18040 ENOG41066VF YeeE YedE family protein FSZ17_RS18050 ENOG41085GJ domain protein FSZ17_RS18055 ENOG4105C8T Leucyl-tRNA synthetase FSZ17_RS18060 ENOG4105DTD Dehydrogenase FSZ17_RS18065 ENOG4105CY2 Citrate transporter FSZ17_RS18080 ENOG410605W Major Facilitator FSZ17_RS18085 ENOG4105EAU Plays a role in nitrite reduction (By similarity) FSZ17_RS18095 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FSZ17_RS18105 ENOG41060IM Heme exporter protein FSZ17_RS18115 ENOG4108IUW ABC transporter FSZ17_RS18135 ENOG4105DA4 cytochrome c-type biogenesis protein FSZ17_RS18160 ENOG4105N5T Radical SAM Protein FSZ17_RS18175 ENOG4105E8V Alpha Beta Hydrolase Fold protein FSZ17_RS18180 ENOG4108Z0R Transferase FSZ17_RS18185 ENOG4105CAQ asparagine synthetase FSZ17_RS18190 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FSZ17_RS18220 ENOG4105D2X ABC transporter substrate-binding protein FSZ17_RS18230 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FSZ17_RS18235 ENOG41087AY ADP-Ribose pyrophosphatase FSZ17_RS18260 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FSZ17_RS18265 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FSZ17_RS18270 ENOG4108V2W Carbonate dehydratase FSZ17_RS18285 ENOG4105CEY Amp-dependent synthetase and ligase FSZ17_RS18290 ENOG4108IPT Naphthoate synthase FSZ17_RS18295 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FSZ17_RS18300 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FSZ17_RS18305 ENOG4105E4F Isochorismate synthase FSZ17_RS18310 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FSZ17_RS18335 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FSZ17_RS18345 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FSZ17_RS18495 ENOG4105KT7 mgtC SapB transporter FSZ17_RS18505 ENOG4107AUC FSZ17_RS18545 ENOG4108J59 Extracellular solute-binding protein, family 5 FSZ17_RS18550 ENOG4105DC7 peptidase M24 FSZ17_RS18565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSZ17_RS18570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FSZ17_RS18575 ENOG4105C26 Dehydrogenase FSZ17_RS18580 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FSZ17_RS18585 ENOG4105CTU Proline racemase FSZ17_RS18590 ENOG4105CTU Proline racemase FSZ17_RS18595 ENOG41080HI glycine oxidase FSZ17_RS18605 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FSZ17_RS18620 ENOG4105CP9 extracellular ligand-binding receptor FSZ17_RS18625 ENOG4105C32 Amino acid ABC transporter (Permease) FSZ17_RS18630 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FSZ17_RS18635 ENOG4105C0Z ABC transporter FSZ17_RS18640 ENOG4108IV0 ABC, transporter FSZ17_RS18645 ENOG4105DC7 peptidase M24 FSZ17_RS18650 ENOG4105DC7 peptidase M24 FSZ17_RS18655 ENOG4108J59 Extracellular solute-binding protein, family 5 FSZ17_RS18660 ENOG4105CI2 imidazolone-5-propionate hydrolase FSZ17_RS18670 ENOG4108JQ7 (ABC) transporter FSZ17_RS18685 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FSZ17_RS18690 ENOG4105DEF Extracellular solute-binding protein, family 5 FSZ17_RS18715 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FSZ17_RS18720 ENOG4107SNB ankyrin repeat protein YahD FSZ17_RS18735 ENOG4107Y2X deaminase FSZ17_RS18745 ENOG4105C5B carbamate kinase FSZ17_RS18755 ENOG4107REC cytoplasmic protein FSZ17_RS18760 ENOG4107R1Q Membrane protein FdrA FSZ17_RS18770 ENOG4105G9B Transcriptional regulator FSZ17_RS18780 ENOG4107PBV potassium channel FSZ17_RS18800 ENOG4105C8Y Acetylornithine aminotransferase FSZ17_RS18805 ENOG4105C26 Dehydrogenase FSZ17_RS18810 ENOG4108JUB Transcriptional regulator FSZ17_RS18825 ENOG4108MUZ hydrolase FSZ17_RS18840 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FSZ17_RS18850 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FSZ17_RS18855 ENOG4105Y38 Kinase-associated protein B FSZ17_RS18865 ENOG4105BZ4 penicillin-binding protein FSZ17_RS18885 ENOG4105D65 subunit l FSZ17_RS18890 ENOG4105HC0 Na H antiporter FSZ17_RS18895 ENOG4108ZE9 Monovalent cation H antiporter subunit C FSZ17_RS18900 ENOG4108JPZ Monovalent cation H antiporter subunit D FSZ17_RS18905 ENOG4105SC1 monovalent cation H antiporter subunit E FSZ17_RS18915 ENOG4105KJM monovalent cation h antiporter subunit g FSZ17_RS18925 ENOG4105KA0 thioesterase Superfamily protein FSZ17_RS18940 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FSZ17_RS18955 ENOG4105DCF alanine dehydrogenase FSZ17_RS18970 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FSZ17_RS18985 ENOG41069ER domain protein FSZ17_RS19000 ENOG4105CEP NADH dehydrogenase FSZ17_RS19010 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FSZ17_RS19020 ENOG4105ZKE UPF0349 protein FSZ17_RS19035 ENOG41083MR nifu domain-containing protein FSZ17_RS19040 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FSZ17_RS19045 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FSZ17_RS19050 ENOG4105D6E homoserine dehydrogenase FSZ17_RS19060 ENOG4108W5N phosphatidylglycerophosphatase a FSZ17_RS19065 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FSZ17_RS19070 ENOG4105D3Q Sugar transferase FSZ17_RS19110 ENOG4105F0R Cytidylyltransferase FSZ17_RS19120 ENOG4105EP9 oxidoreductase FSZ17_RS19130 ENOG4105D2T synthase FSZ17_RS19145 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG FSZ17_RS19150 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FSZ17_RS19155 ENOG4105C5E polysaccharide biosynthesis protein FSZ17_RS19160 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FSZ17_RS19165 ENOG4105D3Q Sugar transferase FSZ17_RS19175 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FSZ17_RS19180 ENOG4105EQQ protein containing aminopeptidase domain FSZ17_RS19190 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FSZ17_RS19195 ENOG4107YJ4 chain length determinant protein FSZ17_RS19200 ENOG4105HTX biosynthesis protein FSZ17_RS19205 ENOG4105D4U had-superfamily hydrolase, subfamily iia FSZ17_RS19215 ENOG4105BZU Histidine kinase FSZ17_RS19230 ENOG4105MMD transcriptional regulator FSZ17_RS19235 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FSZ17_RS19240 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FSZ17_RS19245 ENOG4105FAA peptidase M23 FSZ17_RS19250 ENOG4108IV0 ABC, transporter FSZ17_RS19255 ENOG4105C0Z ABC transporter FSZ17_RS19260 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FSZ17_RS19265 ENOG4105C32 Amino acid ABC transporter (Permease) FSZ17_RS19270 ENOG4105CP9 extracellular ligand-binding receptor FSZ17_RS19275 ENOG4105CPI Metal Dependent Phosphohydrolase FSZ17_RS19285 ENOG4105KZD Domain of unknown function (DUF1805) FSZ17_RS19290 ENOG4105I3N Conserved Protein FSZ17_RS19295 ENOG4105DIW FeS assembly protein SUFB FSZ17_RS19300 ENOG4108UNV SUF system FeS assembly protein, NifU family FSZ17_RS19305 ENOG4105C9B Cysteine desulfurase FSZ17_RS19310 ENOG4105JRK feS assembly protein SufD FSZ17_RS19315 ENOG4105C3K feS assembly ATPase SufC FSZ17_RS19325 ENOG4105D01 (LipO)protein FSZ17_RS19330 ENOG4108UMI ABC transporter, permease FSZ17_RS19335 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FSZ17_RS19365 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FSZ17_RS19370 ENOG41080E8 Transcriptional regulator, Spx MgsR family FSZ17_RS19375 ENOG4105C1G acyl-Coa dehydrogenase FSZ17_RS19380 ENOG4105CHU acetyl-coa acetyltransferase FSZ17_RS19400 ENOG4105E0A ABC, transporter FSZ17_RS19405 ENOG4108IHU transport system permease protein FSZ17_RS19410 ENOG4105DQ5 transport system permease protein FSZ17_RS19415 ENOG4108MES Periplasmic binding protein FSZ17_RS19425 ENOG4108B31 Spore germination protein FSZ17_RS19450 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FSZ17_RS19465 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FSZ17_RS19470 ENOG410904N short-chain dehydrogenase reductase FSZ17_RS19480 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FSZ17_RS19495 ENOG4105EYF MMPL domain protein FSZ17_RS19500 ENOG41067TZ transcriptional regulator, MarR family FSZ17_RS19505 ENOG4108UZ3 Transporter FSZ17_RS19510 ENOG4107T5V SNARE associated Golgi FSZ17_RS19520 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FSZ17_RS19525 ENOG4105BZ1 (ABC) transporter FSZ17_RS19545 ENOG4105C85 amino acid FSZ17_RS19555 ENOG4108VD1 dedA family FSZ17_RS19585 ENOG4107TXC Transcriptional regulator FSZ17_RS19590 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FSZ17_RS19615 ENOG4105CIG ABC transporter FSZ17_RS19630 ENOG4108ZIT Ferredoxin, 2FE-2S FSZ17_RS19640 ENOG4108HGU Histidine kinase FSZ17_RS19645 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FSZ17_RS19650 ENOG41087NI Sulfite exporter TauE/SafE FSZ17_RS19655 ENOG4105VFE sira family FSZ17_RS19660 ENOG4107TPS domain protein FSZ17_RS19665 ENOG4105WAZ (Glutaredoxin-like protein) NrdH FSZ17_RS19670 ENOG4105VFE sira family FSZ17_RS19675 ENOG4105VFE sira family FSZ17_RS19685 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FSZ17_RS19695 ENOG4105XTG Pfam:DUF156 FSZ17_RS19705 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FSZ17_RS19710 ENOG4105C19 ABC transporter FSZ17_RS19735 ENOG4105UA4 acetyltransferase FSZ17_RS19740 ENOG4108Z7R Chaperone CsaA FSZ17_RS19745 ENOG4105E7U AraC family transcriptional regulator FSZ17_RS19775 ENOG4105DXI Major Facilitator superfamily FSZ17_RS19785 ENOG41068WN FSZ17_RS19790 ENOG4105BZU Histidine kinase FSZ17_RS19805 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FSZ17_RS19830 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FSZ17_RS19840 ENOG4105DUM transcriptional regulator, lysR family FSZ17_RS19850 ENOG4105PF9 Transcriptional regulator FSZ17_RS19855 ENOG4105IIP Membrane FSZ17_RS19905 ENOG4108ZGX Histidine kinase FSZ17_RS19915 ENOG4105C5H ABC transporter FSZ17_RS19920 ENOG4105KAC Antibiotic biosynthesis monooxygenase FSZ17_RS19925 ENOG4108ZHR arsR family transcriptional regulator FSZ17_RS19930 ENOG4105M4P Tetr family transcriptional regulator FSZ17_RS19935 ENOG4105F27 Major Facilitator FSZ17_RS19940 ENOG4107RT3 EamA-like transporter family FSZ17_RS19950 ENOG4107QJQ Mate efflux family protein FSZ17_RS19965 ENOG4105H67 Protein of unknown function (DUF421) FSZ17_RS19990 ENOG4108RYK Nad-dependent epimerase dehydratase FSZ17_RS19995 ENOG4108Z40 Transcriptional regulator FSZ17_RS20025 ENOG4105F0V Cell wall hydrolase FSZ17_RS20060 ENOG4105C59 p-type ATPase FSZ17_RS20065 ENOG410681U heavy metal transport detoxification protein FSZ17_RS20075 ENOG4105F6S Spore photoproduct lyase FSZ17_RS20090 ENOG410606W general stress protein FSZ17_RS20115 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FSZ17_RS20150 ENOG4105E7W lamb ycsf family protein FSZ17_RS20155 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FSZ17_RS20180 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FSZ17_RS20185 ENOG4105CJ1 ABC, transporter FSZ17_RS20200 ENOG4105CTU Proline racemase FSZ17_RS20230 ENOG4105F6J Alpha beta hydrolase fold FSZ17_RS20265 ENOG4108TVJ Nitroreductase FSZ17_RS20280 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FSZ17_RS20285 ENOG4105BZU Histidine kinase FSZ17_RS20290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FSZ17_RS20325 ENOG4107ZQN disulfide bond FSZ17_RS20335 ENOG4108MRH transcriptional regulatory protein FSZ17_RS20350 ENOG41086B8 CoB-CoM heterodisulfide reductase FSZ17_RS20355 ENOG4105E33 succinate dehydrogenase FSZ17_RS20360 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FSZ17_RS20370 ENOG4107QPK )-transporter FSZ17_RS20380 ENOG4105H3G oxidoreductase FSZ17_RS20390 ENOG4105DBI uridine monophosphokinase FSZ17_RS20405 ENOG4105KWG Pfam:DUF1696 FSZ17_RS20410 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FSZ17_RS20425 ENOG410667J hydrolase FSZ17_RS20440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FSZ17_RS20445 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FSZ17_RS20465 ENOG4108R5S membrane FSZ17_RS20470 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FSZ17_RS20490 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FSZ17_RS20500 ENOG4105WH1 Two component transcriptional regulator luxr family FSZ17_RS20505 ENOG4108XG2 Histidine kinase FSZ17_RS20515 ENOG4105D01 (LipO)protein FSZ17_RS20520 ENOG4108UMI ABC transporter, permease FSZ17_RS20525 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FSZ17_RS20540 ENOG4108V06 Glutathione peroxidase FSZ17_RS20550 ENOG4105QAX Iron-sulfur FSZ17_RS20555 ENOG4107QY8 reductase FSZ17_RS20565 ENOG4107VHA regulatoR FSZ17_RS20570 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FSZ17_RS20610 ENOG41062D9 Histidine kinase FSZ17_RS20615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FSZ17_RS20620 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FSZ17_RS20635 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FSZ17_RS20675 ENOG4105C5H ABC transporter FSZ17_RS20715 ENOG4108UXE Protein tyrosine phosphatase FSZ17_RS20720 ENOG4107R5R arsenical pump membrane protein FSZ17_RS20725 ENOG41082YX Transcriptional regulator, arsr family FSZ17_RS20750 ENOG4107QVI Methyltransferase, type 11 FSZ17_RS20760 ENOG4105E5Q amino acid AbC transporter FSZ17_RS20775 ENOG4105CDA abc transporter atp-binding protein FSZ17_RS20785 ENOG4105DRR Transcriptional regulator, GntR family FSZ17_RS20800 ENOG41089UC methyltransferase, type 11 FSZ17_RS20815 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FSZ17_RS20820 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FSZ17_RS20830 ENOG4105XZU Preprotein translocase, subunit SecG FSZ17_RS20835 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FSZ17_RS20840 ENOG4108Z7G MaoC domain protein dehydratase FSZ17_RS20865 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FSZ17_RS20870 ENOG4105CP7 Triose-phosphate isomerase FSZ17_RS20875 ENOG4105BZA Phosphoglycerate kinase FSZ17_RS20900 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FSZ17_RS20910 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FSZ17_RS20915 ENOG4105KRI phosphocarrier protein (HPr FSZ17_RS20920 ENOG4105CIE May be required for sporulation (By similarity) FSZ17_RS20925 ENOG4105CHW UPF0052 protein FSZ17_RS20930 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FSZ17_RS20935 ENOG4108Z4K mutator MutT protein FSZ17_RS20940 ENOG4105C3M thioredoxin reductase FSZ17_RS20955 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FSZ17_RS20960 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FSZ17_RS20965 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FSZ17_RS20970 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FSZ17_RS20975 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FSZ17_RS20980 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FSZ17_RS20985 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FSZ17_RS20990 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FSZ17_RS20995 ENOG4108S4C acetyltransferase FSZ17_RS21005 ENOG4105HKU nucleoside recognition domain-containing protein FSZ17_RS21015 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FSZ17_RS21025 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FSZ17_RS21035 ENOG41086DT Membrane protein of unknown function FSZ17_RS21040 ENOG4108PY7 FSZ17_RS21055 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FSZ17_RS21060 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FSZ17_RS21085 ENOG4108IQI permease FSZ17_RS21090 ENOG4108URH decarboxylase FSZ17_RS21100 ENOG410751J FSZ17_RS21125 ENOG4105F04 LysR family Transcriptional regulator FSZ17_RS21130 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FSZ17_RS21135 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FSZ17_RS21145 ENOG4105E98 transcriptional regulator DeoR family FSZ17_RS21165 ENOG4105CBC glutamate synthase FSZ17_RS21180 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FSZ17_RS21185 ENOG4108N23 SpoOM-related protein FSZ17_RS21230 ENOG4105CN1 protease FSZ17_RS21235 ENOG4105CRP Part of the ABC transporter FtsEX involved in FSZ17_RS21240 ENOG4105CAK Cell division ATP-binding protein ftsE FSZ17_RS21265 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FSZ17_RS21270 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FSZ17_RS21285 ENOG41069ZS flagellar protein FSZ17_RS21290 ENOG4105MQ3 flagellar protein FliS FSZ17_RS21295 ENOG4107RT6 flagellar hook-associated FSZ17_RS21300 ENOG41083S7 flagellar protein FlaG FSZ17_RS21310 ENOG4105I03 Flagellin FSZ17_RS21315 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FSZ17_RS21320 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) FSZ17_RS21330 ENOG4105DTJ flagellar hook-associated protein FSZ17_RS21335 ENOG4105E1Q flagellar hook-associated protein FSZ17_RS21345 ENOG4105XVJ Protein of unknown function (DUF327) FSZ17_RS21350 ENOG4105I03 Flagellin FSZ17_RS21380 ENOG4107VCP Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FSZ17_RS21405 ENOG4105WH1 Two component transcriptional regulator luxr family FSZ17_RS21415 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FSZ17_RS21420 ENOG4108KGH TRANSCRIPTIONal FSZ17_RS21425 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FSZ17_RS21435 ENOG4105JFG SpoIID LytB domain protein FSZ17_RS21445 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FSZ17_RS21450 ENOG4105CPK Glycosyl transferase (Group 1 FSZ17_RS21465 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FSZ17_RS21485 ENOG4107QQG Dehydrogenase FSZ17_RS21505 ENOG4105ESV Glycosyl transferase, family 4 FSZ17_RS21510 ENOG4106KBF Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) FSZ17_RS21525 ENOG4108QBX (LipO)protein FSZ17_RS21550 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FSZ17_RS21570 ENOG4105CGH 5'-nucleotidase FSZ17_RS21600 ENOG4108JJ8 (ABC) transporter FSZ17_RS21605 ENOG4108JJ9 ABC, transporter FSZ17_RS21610 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FSZ17_RS21615 ENOG4105C4M (Ubiquinol oxidase) subunit I FSZ17_RS21620 ENOG4105BZU Histidine kinase FSZ17_RS21625 ENOG4105C7K acetolactate synthase FSZ17_RS21630 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FSZ17_RS21650 ENOG4108KGH TRANSCRIPTIONal FSZ17_RS21655 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FSZ17_RS21745 ENOG4105D6E homoserine dehydrogenase FSZ17_RS21750 ENOG4105CEM UPF0597 protein FSZ17_RS21775 ENOG41069ER domain protein FSZ17_RS21780 ENOG4105KBK Zinc finger, swim domain protein FSZ17_RS21785 ENOG4105C0D helicase FSZ17_RS21795 ENOG4105Z8H single-stranded DNA-binding protein FSZ17_RS21825 ENOG4105CGA flagellar basal-body rod protein FlgG FSZ17_RS21835 ENOG4105DFF Rod shape-determining protein mreb FSZ17_RS21840 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FSZ17_RS21845 ENOG4105K4H Nlp p60 protein FSZ17_RS21850 ENOG4105FRN stage II sporulation protein FSZ17_RS21870 ENOG4106778 Protein of unknown function (DUF1146) FSZ17_RS21875 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FSZ17_RS21880 ENOG4105C8S subunit m FSZ17_RS21885 ENOG4105D65 subunit l FSZ17_RS21890 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FSZ17_RS21900 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FSZ17_RS21905 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FSZ17_RS21915 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FSZ17_RS21920 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FSZ17_RS21925 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FSZ17_RS21930 ENOG4107VC0 DNA alkylation repair enzyme FSZ17_RS21935 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FSZ17_RS21940 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FSZ17_RS21945 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FSZ17_RS21950 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FSZ17_RS21955 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FSZ17_RS21960 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FSZ17_RS21965 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FSZ17_RS21970 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FSZ17_RS21975 ENOG41062M3 atp synthase FSZ17_RS21985 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FSZ17_RS21990 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FSZ17_RS21995 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FSZ17_RS22000 ENOG4108UIC UPF0340 protein FSZ17_RS22005 ENOG4108YZG isomerase FSZ17_RS22010 ENOG4105C8Q Methyl-accepting chemotaxis FSZ17_RS22020 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FSZ17_RS22030 ENOG4108ZXQ stage ii sporulation protein r FSZ17_RS22035 ENOG410815N Probably functions as a manganese efflux pump (By similarity) FSZ17_RS22040 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FSZ17_RS22045 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FSZ17_RS22050 ENOG4105DRR Transcriptional regulator, GntR family FSZ17_RS22070 ENOG4107104 thymidine kinase FSZ17_RS22075 ENOG4105VFB Binds the 23S rRNA (By similarity) FSZ17_RS22080 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FSZ17_RS22085 ENOG4105CBT Fructose-1,6-bisphosphatase FSZ17_RS22095 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FSZ17_RS22100 ENOG4105D2N Aldolase FSZ17_RS22105 ENOG410812K response regulator receiver protein FSZ17_RS22115 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FSZ17_RS22130 ENOG4105D5P Methylmalonyl-coA mutase FSZ17_RS22140 ENOG4105C1G acyl-Coa dehydrogenase FSZ17_RS22145 ENOG4105C1G acyl-Coa dehydrogenase FSZ17_RS22150 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FSZ17_RS22160 ENOG4105DF6 Fe-S oxidoreductase FSZ17_RS22175 ENOG4105C75 arginyL-tRNA synthetase FSZ17_RS22180 ENOG410684U Domain of unknown function (DUF1934) FSZ17_RS22185 ENOG4105CYW agmatinase FSZ17_RS22195 ENOG4105BZ4 penicillin-binding protein FSZ17_RS22200 ENOG4108XFG YwhD family FSZ17_RS22205 ENOG4108Z4T Peptidase M50 FSZ17_RS22210 ENOG41069HH 4-oxalocrotonate tautomerase FSZ17_RS22220 ENOG4105DCI Phosphohydrolase FSZ17_RS22230 ENOG4108VCI transcription factor, rsfa family FSZ17_RS22235 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FSZ17_RS22240 ENOG4108IJ2 phosphate acetyltransferase FSZ17_RS22245 ENOG4107JTW chlorite dismutase FSZ17_RS22265 ENOG4105D06 uba thif-type nad fad binding protein FSZ17_RS22275 ENOG4108ZAF Molybdopterin FSZ17_RS22280 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FSZ17_RS22285 ENOG4105CVM Molybdenum cofactor synthesis domain protein FSZ17_RS22290 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FSZ17_RS22305 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FSZ17_RS22315 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FSZ17_RS22320 ENOG4105NQN cytochrome C FSZ17_RS22325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FSZ17_RS22355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FSZ17_RS22360 ENOG4105DWF phosphomethylpyrimidine kinase FSZ17_RS22370 ENOG4108TN2 lmbE family FSZ17_RS22385 ENOG4107RYR Transcriptional regulator, Crp Fnr family FSZ17_RS22410 ENOG4105CJ1 ABC, transporter FSZ17_RS22415 ENOG41090VJ ABC-2 type transporter FSZ17_RS22420 ENOG4105EJ2 Transcriptional regulator FSZ17_RS22425 ENOG4105D8V Glucose sorbosone dehydrogenase FSZ17_RS22430 ENOG410667J hydrolase FSZ17_RS22445 ENOG4107SWG transcriptional regulator MERR family FSZ17_RS22450 ENOG4105BZ1 (ABC) transporter FSZ17_RS22455 ENOG4105CRW Short chain fatty acid transporter FSZ17_RS22460 ENOG4105CJ1 ABC, transporter FSZ17_RS22475 ENOG4105DWD nucleoside recognition domain protein FSZ17_RS22490 ENOG4108Z66 YbaK ebsC protein FSZ17_RS22495 ENOG4105BZU Histidine kinase FSZ17_RS22505 ENOG4105DUX Transporter FSZ17_RS22520 ENOG4108KPJ rna polymerase sigma factor FSZ17_RS22525 ENOG4105D5D udp-galactopyranose mutase FSZ17_RS22535 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FSZ17_RS22550 ENOG4105CHR reductase FSZ17_RS22555 ENOG4105E0X reductase FSZ17_RS22575 ENOG4105JVQ RNA Polymerase FSZ17_RS22595 ENOG4105C8Q Methyl-accepting chemotaxis FSZ17_RS22610 ENOG4107MII Sugar-specific transcriptional regulator TrmB FSZ17_RS22615 ENOG4105CZM Major Facilitator FSZ17_RS22620 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FSZ17_RS22640 ENOG4105RD7 BadF BadG BcrA BcrD FSZ17_RS22655 ENOG4108JP0 extracellular solute-binding protein family 1 FSZ17_RS22665 ENOG4106KNT transcriptional regulator FSZ17_RS22685 ENOG4105D7K pfkb domain protein FSZ17_RS22700 ENOG4105D9N nucleoside FSZ17_RS22735 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FSZ17_RS22740 ENOG4108IG5 Transcriptional regulator FSZ17_RS22765 ENOG4108Z5V transcriptional regulator, merr family FSZ17_RS22790 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FSZ17_RS22800 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FSZ17_RS22805 ENOG4106BRA Membrane FSZ17_RS22825 ENOG4108JQ1 Dehydrogenase FSZ17_RS22830 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FSZ17_RS22840 ENOG4105BZU Histidine kinase FSZ17_RS22845 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FSZ17_RS22855 ENOG4105C7S Dehydrogenase FSZ17_RS22860 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FSZ17_RS22865 ENOG4107QPK )-transporter FSZ17_RS22880 ENOG4105C5I Dehydrogenase FSZ17_RS22885 ENOG4108MRH transcriptional regulatory protein FSZ17_RS22900 ENOG4108B31 Spore germination protein FSZ17_RS22905 ENOG4105E1K spore germination protein FSZ17_RS22915 ENOG4108Y4K DNA-binding transcriptional activator FSZ17_RS22925 ENOG4105DWT malate dehydrogenase (quinone) FSZ17_RS22930 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FSZ17_RS22955 ENOG4105PUK Membrane FSZ17_RS22980 ENOG4105II7 pyrroline-5-carboxylate reductase FSZ17_RS22985 ENOG4105FEA Spore maturation protein FSZ17_RS22990 ENOG4105FEA Spore maturation protein FSZ17_RS22995 ENOG4105FEA Spore maturation protein FSZ17_RS23010 ENOG4105E4C Lytic transglycosylase catalytic FSZ17_RS23015 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FSZ17_RS23020 ENOG4105DGI Alkaline phosphatase FSZ17_RS23030 ENOG4105PKS Excinuclease abc c subunit domain protein FSZ17_RS23040 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FSZ17_RS23050 ENOG4105C0H protease FSZ17_RS23055 ENOG4105Q2H domain protein FSZ17_RS23070 ENOG4105BZU Histidine kinase FSZ17_RS23075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FSZ17_RS23080 ENOG4105E4C Lytic transglycosylase catalytic FSZ17_RS23100 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FSZ17_RS23105 ENOG4105CDU Replicative dna helicase FSZ17_RS23110 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FSZ17_RS23115 ENOG4105BZR domain protein FSZ17_RS23125 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FSZ17_RS23130 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FSZ17_RS23135 ENOG4108UUM single-stranded DNA-binding protein FSZ17_RS23140 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FSZ17_RS23160 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FSZ17_RS23165 ENOG4105C3G gtp-binding protein FSZ17_RS23170 ENOG4105VDK protein, conserved in bacteria FSZ17_RS23175 ENOG4105D8X mechanosensitive ion channel FSZ17_RS23180 ENOG4108ZDA Sporulation protein YyaC FSZ17_RS23190 ENOG4105FA0 parb-like partition protein FSZ17_RS23195 ENOG4107QJE Chromosome Partitioning Protein FSZ17_RS23200 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) FSZ17_RS23205 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FSZ17_RS23210 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FSZ17_RS23215 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FSZ17_RS23230 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FSZ17_RS23235 ENOG4105VG0 50S ribosomal protein l34