locus-tag	class	description
FED53_RS00070	COG3177	Filamentation induced by cAMP protein fic
FED53_RS00120	COG2226	methyltransferase
FED53_RS00205	COG0546	phosphoglycolate phosphatase activity
FED53_RS00210	COG2205	protein histidine kinase activity
FED53_RS00290	COG0791	NLP P60 protein
FED53_RS00290	COG0741	lytic transglycosylase activity
FED53_RS00355	COG1376	ErfK ybiS ycfS ynhG family protein
FED53_RS00400	COG1063	alcohol dehydrogenase
FED53_RS00405	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FED53_RS00410	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FED53_RS00415	COG1733	regulation of RNA biosynthetic process
FED53_RS00420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FED53_RS00425	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FED53_RS00440	COG2801	Transposase and inactivated derivatives
FED53_RS00460	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FED53_RS00465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FED53_RS00470	COG0659	secondary active sulfate transmembrane transporter activity
FED53_RS00475	COG0589	response to stress
FED53_RS00480	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FED53_RS00500	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FED53_RS00680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FED53_RS00685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FED53_RS00690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FED53_RS00700	COG0590	tRNA wobble adenosine to inosine editing
FED53_RS00705	COG1335	isochorismatase
FED53_RS00710	COG1388	LysM domain
FED53_RS00710	COG3858	chitin binding
FED53_RS00715	COG1428	Deoxynucleoside kinase
FED53_RS00720	COG1428	Deoxynucleoside kinase
FED53_RS00730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FED53_RS00735	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FED53_RS00750	COG0516	GMP reductase activity
FED53_RS00750	COG0517	IMP dehydrogenase activity
FED53_RS00785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FED53_RS00790	COG0187	DNA topoisomerase II activity
FED53_RS00795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FED53_RS00800	COG2501	S4 domain
FED53_RS00805	COG0592	DNA-directed DNA polymerase activity
FED53_RS00810	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FED53_RS00820	COG0594	ribonuclease P activity
FED53_RS00825	COG0706	membrane insertase activity
FED53_RS00830	COG1847	R3H domain protein
FED53_RS00835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FED53_RS00840	COG0445	tRNA wobble uridine modification
FED53_RS00850	COG1475	DNA binding
FED53_RS00855	COG1192	Involved in chromosome partitioning
FED53_RS00870	COG3949	Membrane
FED53_RS00875	COG0668	transmembrane transport
FED53_RS00880	COG4481	Protein conserved in bacteria
FED53_RS00885	COG0012	GTP binding
FED53_RS00890	COG0360	Binds together with S18 to 16S ribosomal RNA
FED53_RS00900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FED53_RS00910	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FED53_RS00920	COG0305	Participates in initiation and elongation during chromosome replication
FED53_RS00925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FED53_RS00950	COG0745	RESPONSE REGULATOR receiver
FED53_RS00955	COG5002	protein histidine kinase activity
FED53_RS00960	COG4863	YycH protein
FED53_RS00965	COG4853	Protein conserved in bacteria
FED53_RS00970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FED53_RS00975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FED53_RS01010	COG1063	alcohol dehydrogenase
FED53_RS01025	COG0697	spore germination
FED53_RS01035	COG2814	Major facilitator Superfamily
FED53_RS01040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FED53_RS01055	COG1464	Belongs to the NlpA lipoprotein family
FED53_RS01065	COG3634	alkyl hydroperoxide reductase activity
FED53_RS01070	COG0450	alkyl hydroperoxide reductase
FED53_RS01075	COG2972	Histidine kinase
FED53_RS01080	COG3279	Response regulator of the LytR AlgR family
FED53_RS01085	COG2182	Extracellular solute-binding protein
FED53_RS01090	COG1621	beta-fructofuranosidase activity
FED53_RS01095	COG1621	beta-fructofuranosidase activity
FED53_RS01115	COG2966	Psort location CytoplasmicMembrane, score
FED53_RS01120	COG3610	response to peptide
FED53_RS01125	COG1368	sulfuric ester hydrolase activity
FED53_RS01135	COG0728	peptidoglycan biosynthetic process
FED53_RS01160	COG0438	transferase activity, transferring glycosyl groups
FED53_RS01170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FED53_RS01170	COG1263	PTS System
FED53_RS01170	COG2190	(PTS) system
FED53_RS01175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FED53_RS01180	COG0561	phosphatase activity
FED53_RS01185	COG0351	phosphomethylpyrimidine kinase
FED53_RS01190	COG0686	Belongs to the AlaDH PNT family
FED53_RS01195	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FED53_RS01195	COG2508	Transcriptional regulator
FED53_RS01200	COG1115	amino acid carrier protein
FED53_RS01205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FED53_RS01210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FED53_RS01220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FED53_RS01230	COG2363	Small membrane protein
FED53_RS01240	COG3773	Cell wall hydrolase
FED53_RS01250	COG0280	phosphate acetyltransferase
FED53_RS01255	COG0095	Lipoate-protein ligase
FED53_RS01270	COG1078	dGTPase activity
FED53_RS01275	COG3465	dGTPase activity
FED53_RS01285	COG1994	Peptidase M50
FED53_RS01295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FED53_RS01300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FED53_RS01305	COG0010	Belongs to the arginase family
FED53_RS01325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FED53_RS01330	COG2181	nitrate reductase activity
FED53_RS01330	COG0247	lactate metabolic process
FED53_RS01335	COG0183	Belongs to the thiolase family
FED53_RS01340	COG1250	3-hydroxyacyl-CoA dehydrogenase
FED53_RS01345	COG1960	acyl-CoA dehydrogenase activity
FED53_RS01350	COG1960	acyl-CoA dehydrogenase activity
FED53_RS01360	COG1703	isobutyryl-CoA mutase activity
FED53_RS01360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FED53_RS01360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FED53_RS01365	COG3343	RNA polymerase activity
FED53_RS01370	COG0504	CTP synthase activity
FED53_RS01375	COG4821	SIS domain
FED53_RS01380	COG2204	response regulator
FED53_RS01385	COG0191	fructose-bisphosphate aldolase activity
FED53_RS01390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FED53_RS01400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FED53_RS01410	COG1435	thymidine kinase activity
FED53_RS01420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FED53_RS01425	COG2890	protein-(glutamine-N5) methyltransferase activity
FED53_RS01440	COG0009	L-threonylcarbamoyladenylate synthase
FED53_RS01445	COG1971	Probably functions as a manganese efflux pump
FED53_RS01455	COG0698	ribose 5-phosphate isomerase
FED53_RS01470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FED53_RS01475	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FED53_RS01480	COG1404	Belongs to the peptidase S8 family
FED53_RS01495	COG0356	it plays a direct role in the translocation of protons across the membrane
FED53_RS01500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FED53_RS01505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FED53_RS01510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FED53_RS01515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FED53_RS01520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FED53_RS01525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FED53_RS01530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FED53_RS01535	COG4836	Membrane
FED53_RS01550	COG2385	sporulation resulting in formation of a cellular spore
FED53_RS01555	COG0739	heme binding
FED53_RS01560	COG1609	Transcriptional regulator
FED53_RS01570	COG4786	Flagellar basal body rod
FED53_RS01575	COG4786	Flagellar basal body rod
FED53_RS01595	COG0629	single-stranded DNA binding
FED53_RS01600	COG0791	NLP P60 protein
FED53_RS01600	COG1388	LysM domain
FED53_RS01605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FED53_RS01615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FED53_RS01625	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FED53_RS01630	COG2268	Band 7 protein
FED53_RS01635	COG1585	Membrane protein implicated in regulation of membrane protease activity
FED53_RS01640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FED53_RS01645	COG1316	TRANSCRIPTIONal
FED53_RS01650	COG1739	Uncharacterized protein family UPF0029
FED53_RS01655	COG4585	Histidine kinase
FED53_RS01660	COG2197	response regulator
FED53_RS01680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FED53_RS01685	COG1728	Protein conserved in bacteria
FED53_RS01690	COG1307	EDD domain protein, DegV family
FED53_RS01695	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FED53_RS01700	COG1040	competence protein
FED53_RS01710	COG2747	anti-sigma28 factor FlgM
FED53_RS01720	COG1256	bacterial-type flagellum assembly
FED53_RS01720	COG4786	Flagellar basal body rod
FED53_RS01725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FED53_RS01735	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
FED53_RS01740	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FED53_RS01745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FED53_RS01750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FED53_RS01770	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FED53_RS01775	COG1516	flagellar protein fliS
FED53_RS01785	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FED53_RS01790	COG0653	protein targeting
FED53_RS01800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FED53_RS01805	COG2010	Cytochrome c
FED53_RS01810	COG2884	Cell division ATP-binding protein ftsE
FED53_RS01815	COG2177	Part of the ABC transporter FtsEX involved in
FED53_RS01820	COG0739	heme binding
FED53_RS01825	COG0793	Belongs to the peptidase S41A family
FED53_RS01825	COG3409	Peptidoglycan-binding domain 1 protein
FED53_RS01830	COG1733	regulation of RNA biosynthetic process
FED53_RS01835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FED53_RS01845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FED53_RS01850	COG0506	proline dehydrogenase activity
FED53_RS01855	COG1012	belongs to the aldehyde dehydrogenase family
FED53_RS01860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FED53_RS01875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FED53_RS01880	COG3595	metallopeptidase activity
FED53_RS01885	COG1983	PspC domain protein
FED53_RS01890	COG1950	PFAM Membrane protein of
FED53_RS01895	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FED53_RS01900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FED53_RS01905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FED53_RS01910	COG0546	phosphoglycolate phosphatase activity
FED53_RS01915	COG0110	maltose O-acetyltransferase activity
FED53_RS01920	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FED53_RS01925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FED53_RS01930	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FED53_RS01935	COG0131	Imidazoleglycerol-phosphate dehydratase
FED53_RS01940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FED53_RS01945	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FED53_RS01950	COG0107	imidazoleglycerol-phosphate synthase activity
FED53_RS01955	COG0140	phosphoribosyl-ATP diphosphatase activity
FED53_RS01955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FED53_RS01960	COG0457	Tetratricopeptide repeat
FED53_RS01965	COG0492	ferredoxin-NADP+ reductase activity
FED53_RS01970	COG1051	belongs to the nudix hydrolase family
FED53_RS01975	COG1660	Displays ATPase and GTPase activities
FED53_RS01980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FED53_RS01985	COG1481	regulation of sporulation
FED53_RS01990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FED53_RS02010	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FED53_RS02050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FED53_RS02055	COG1647	Serine aminopeptidase, S33
FED53_RS02060	COG0557	exoribonuclease II activity
FED53_RS02065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FED53_RS02085	COG0477	Major facilitator Superfamily
FED53_RS02095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FED53_RS02100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FED53_RS02105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FED53_RS02110	COG1120	ATPase activity
FED53_RS02135	COG1250	3-hydroxyacyl-CoA dehydrogenase
FED53_RS02135	COG1024	Enoyl-CoA hydratase
FED53_RS02140	COG0183	Belongs to the thiolase family
FED53_RS02145	COG1960	acyl-CoA dehydrogenase activity
FED53_RS02150	COG1393	Belongs to the ArsC family
FED53_RS02155	COG0509	glycine decarboxylation via glycine cleavage system
FED53_RS02165	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FED53_RS02175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FED53_RS02180	COG2011	ABC-type metal ion transport system permease component
FED53_RS02185	COG1464	Belongs to the NlpA lipoprotein family
FED53_RS02190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FED53_RS02195	COG0396	ATPase activity
FED53_RS02200	COG0719	Fe-S assembly protein
FED53_RS02205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FED53_RS02210	COG0822	iron-sulfur transferase activity
FED53_RS02215	COG0719	Fe-S assembly protein
FED53_RS02220	COG1801	Protein of unknown function DUF72
FED53_RS02225	COG3377	Domain of unknown function (DUF1805)
FED53_RS02245	COG1376	ErfK ybiS ycfS ynhG family protein
FED53_RS02255	COG3655	Transcriptional regulator
FED53_RS02275	COG1757	Na H antiporter
FED53_RS02280	COG0733	neurotransmitter:sodium symporter activity
FED53_RS02290	COG0739	heme binding
FED53_RS02295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FED53_RS02305	COG4470	Protein conserved in bacteria
FED53_RS02315	COG2445	Protein of unknown function DUF86
FED53_RS02320	COG0647	UMP catabolic process
FED53_RS02325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FED53_RS02330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FED53_RS02335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FED53_RS02340	COG0460	homoserine dehydrogenase
FED53_RS02345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FED53_RS02350	COG0083	homoserine kinase activity
FED53_RS02355	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FED53_RS02360	COG4837	Protein of unknown function (DUF1462)
FED53_RS02365	COG1252	NADH dehydrogenase
FED53_RS02370	COG4844	belongs to the
FED53_RS02380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FED53_RS02385	COG0316	Belongs to the HesB IscA family
FED53_RS02395	COG0492	ferredoxin-NADP+ reductase activity
FED53_RS02400	COG1252	NADH dehydrogenase
FED53_RS02410	COG3584	3D domain protein
FED53_RS02415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FED53_RS02420	COG2056	Na+-H+ antiporter family
FED53_RS02430	COG1418	mRNA catabolic process
FED53_RS02435	COG2050	protein possibly involved in aromatic compounds catabolism
FED53_RS02440	COG5018	Exonuclease
FED53_RS02455	COG2032	superoxide dismutase activity
FED53_RS02460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FED53_RS02465	COG2267	carboxylic ester hydrolase activity
FED53_RS02470	COG1522	sequence-specific DNA binding
FED53_RS02475	COG0436	Aminotransferase
FED53_RS02480	COG1098	S1 RNA binding domain
FED53_RS02485	COG2155	Conserved Protein
FED53_RS02490	COG1979	alcohol dehydrogenase
FED53_RS02495	COG1320	monovalent cation:proton antiporter activity
FED53_RS02500	COG2212	antiporter activity
FED53_RS02505	COG1863	multisubunit Na H antiporter MnhE subunit
FED53_RS02510	COG0651	ATP synthesis coupled electron transport
FED53_RS02515	COG1006	Multisubunit Na H antiporter MnhC subunit
FED53_RS02520	COG2111	Na H antiporter
FED53_RS02525	COG2111	Na H antiporter
FED53_RS02525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FED53_RS02535	COG0166	Belongs to the GPI family
FED53_RS02545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FED53_RS02550	COG0346	lactoylglutathione lyase activity
FED53_RS02555	COG1115	amino acid carrier protein
FED53_RS02560	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FED53_RS02575	COG0306	phosphate transporter
FED53_RS02585	COG0529	Catalyzes the synthesis of activated sulfate
FED53_RS02605	COG1285	pathogenesis
FED53_RS02610	COG0318	PFAM AMP-dependent synthetase and ligase
FED53_RS02740	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FED53_RS02745	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FED53_RS02755	COG0058	SHG alpha-glucan phosphorylase activity
FED53_RS02760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FED53_RS02765	COG1169	isochorismate synthase
FED53_RS02770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FED53_RS02775	COG0596	Alpha beta hydrolase
FED53_RS02780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FED53_RS02785	COG0318	PFAM AMP-dependent synthetase and ligase
FED53_RS02790	COG4948	Mandelate Racemase Muconate Lactonizing
FED53_RS02795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FED53_RS02800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FED53_RS02825	COG1294	oxidase, subunit
FED53_RS02830	COG1271	oxidase subunit
FED53_RS02835	COG0254	rRNA binding
FED53_RS02840	COG0803	Belongs to the bacterial solute-binding protein 9 family
FED53_RS02845	COG0523	cobalamin synthesis protein
FED53_RS02850	COG0288	reversible hydration of carbon dioxide
FED53_RS02855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FED53_RS02860	COG1854	S-ribosylhomocysteine lyase activity
FED53_RS02870	COG0783	Belongs to the Dps family
FED53_RS02875	COG4824	toxin secretion phage lysis holin
FED53_RS02885	COG0494	nUDIX hydrolase
FED53_RS02890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FED53_RS02895	COG1116	anion transmembrane transporter activity
FED53_RS02900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FED53_RS02905	COG1506	peptidase
FED53_RS02915	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FED53_RS02920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FED53_RS02925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FED53_RS02925	COG0438	transferase activity, transferring glycosyl groups
FED53_RS02935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FED53_RS02940	COG2267	carboxylic ester hydrolase activity
FED53_RS02950	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FED53_RS02955	COG1242	4 iron, 4 sulfur cluster binding
FED53_RS02970	COG2814	Major facilitator Superfamily
FED53_RS02975	COG2610	gluconate transmembrane transporter activity
FED53_RS02980	COG0495	leucyl-tRNA aminoacylation
FED53_RS02985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FED53_RS02995	COG2081	HI0933 family
FED53_RS03000	COG2244	polysaccharide biosynthetic process
FED53_RS03010	COG1187	pseudouridine synthase activity
FED53_RS03015	COG1349	DNA-binding transcription factor activity
FED53_RS03020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FED53_RS03025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FED53_RS03035	COG1523	belongs to the glycosyl hydrolase 13 family
FED53_RS03040	COG0510	thiamine kinase activity
FED53_RS03050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FED53_RS03055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FED53_RS03065	COG1363	Peptidase, m42
FED53_RS03070	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FED53_RS03075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FED53_RS03080	COG4848	Belongs to the UPF0354 family
FED53_RS03085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FED53_RS03090	COG1674	ftsk spoiiie
FED53_RS03100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FED53_RS03115	COG4980	gas vesicle protein
FED53_RS03120	COG3118	belongs to the thioredoxin family
FED53_RS03125	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FED53_RS03125	COG1605	Chorismate mutase
FED53_RS03145	COG0123	including yeast histone deacetylase and acetoin utilization protein
FED53_RS03150	COG0517	IMP dehydrogenase activity
FED53_RS03155	COG0454	-acetyltransferase
FED53_RS03160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FED53_RS03180	COG2203	Gaf domain
FED53_RS03180	COG2199	diguanylate cyclase activity
FED53_RS03185	COG1956	GAF domain-containing protein
FED53_RS03190	COG1309	transcriptional regulator
FED53_RS03195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FED53_RS03200	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FED53_RS03205	COG1114	Component of the transport system for branched-chain amino acids
FED53_RS03210	COG1104	cysteine desulfurase activity
FED53_RS03215	COG0301	tRNA thio-modification
FED53_RS03225	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FED53_RS03230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FED53_RS03235	COG0616	signal peptide processing
FED53_RS03240	COG1714	RDD family
FED53_RS03250	COG3874	Sporulation protein YtfJ
FED53_RS03255	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FED53_RS03260	COG0827	DNA restriction-modification system
FED53_RS03265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FED53_RS03280	COG0137	argininosuccinate synthase activity
FED53_RS03285	COG0165	Argininosuccinate lyase
FED53_RS03295	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FED53_RS03305	COG4109	DRTGG domain
FED53_RS03315	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FED53_RS03330	COG0587	DNA-directed DNA polymerase activity
FED53_RS03335	COG0281	malic enzyme
FED53_RS03340	COG1725	Transcriptional regulator
FED53_RS03345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FED53_RS03350	COG0825	malonyl-CoA metabolic process
FED53_RS03360	COG3030	protein affecting phage T7 exclusion by the F plasmid
FED53_RS03365	COG0628	permease
FED53_RS03370	COG2707	UPF0756 membrane protein
FED53_RS03375	COG0372	Belongs to the citrate synthase family
FED53_RS03380	COG0538	isocitrate dehydrogenase activity
FED53_RS03385	COG0039	L-malate dehydrogenase activity
FED53_RS03395	COG0745	RESPONSE REGULATOR receiver
FED53_RS03400	COG5002	protein histidine kinase activity
FED53_RS03405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FED53_RS03405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FED53_RS03410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FED53_RS03415	COG1971	Probably functions as a manganese efflux pump
FED53_RS03420	COG0237	dephospho-CoA kinase activity
FED53_RS03425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FED53_RS03440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FED53_RS03445	COG3611	Membrane attachment protein
FED53_RS03450	COG1484	DNA-dependent DNA replication
FED53_RS03460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FED53_RS03465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FED53_RS03470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FED53_RS03475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FED53_RS03480	COG3326	Membrane
FED53_RS03495	COG1363	Peptidase, m42
FED53_RS03505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FED53_RS03510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FED53_RS03515	COG0072	phenylalanine-tRNA ligase activity
FED53_RS03515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FED53_RS03520	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FED53_RS03525	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FED53_RS03530	COG1286	toxin biosynthetic process
FED53_RS03535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FED53_RS03535	COG1796	DNA polymerase
FED53_RS03540	COG1193	negative regulation of DNA recombination
FED53_RS03545	COG3766	membrane
FED53_RS03550	COG0318	PFAM AMP-dependent synthetase and ligase
FED53_RS03555	COG1309	transcriptional regulator
FED53_RS03560	COG1024	Enoyl-CoA hydratase
FED53_RS03565	COG2086	electron transfer activity
FED53_RS03570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FED53_RS03575	COG3118	belongs to the thioredoxin family
FED53_RS03580	COG0322	excinuclease ABC activity
FED53_RS03585	COG0527	aspartate kinase activity
FED53_RS03590	COG1719	4-vinyl reductase, 4VR
FED53_RS03595	COG2009	succinate dehydrogenase
FED53_RS03600	COG1053	succinate dehydrogenase
FED53_RS03605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FED53_RS03610	COG2197	response regulator
FED53_RS03620	COG0490	domain, Protein
FED53_RS03625	COG0475	glutathione-regulated potassium exporter activity
FED53_RS03635	COG0768	penicillin binding
FED53_RS03640	COG1392	Phosphate transport regulator
FED53_RS03645	COG0306	phosphate transporter
FED53_RS03650	COG1846	Transcriptional regulator
FED53_RS03660	COG5401	PFAM Sporulation and spore germination
FED53_RS03665	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FED53_RS03675	COG0622	Phosphoesterase
FED53_RS03685	COG0028	Belongs to the TPP enzyme family
FED53_RS03690	COG0440	acetolactate synthase activity
FED53_RS03695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FED53_RS03700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FED53_RS03710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FED53_RS03715	COG0066	3-isopropylmalate dehydratase activity
FED53_RS03720	COG1477	protein flavinylation
FED53_RS03720	COG0457	Tetratricopeptide repeat
FED53_RS03725	COG0544	peptidyl-prolyl cis-trans isomerase activity
FED53_RS03730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FED53_RS03735	COG1067	ATP-dependent peptidase activity
FED53_RS03735	COG0470	DNA polymerase III
FED53_RS03745	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FED53_RS03760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FED53_RS03765	COG0181	hydroxymethylbilane synthase activity
FED53_RS03775	COG0113	porphobilinogen synthase activity
FED53_RS03780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FED53_RS03785	COG1388	LysM domain
FED53_RS03800	COG0525	valine-tRNA ligase activity
FED53_RS03805	COG0285	dihydrofolate synthase activity
FED53_RS03815	COG2322	membrane
FED53_RS03825	COG1459	type II secretion system
FED53_RS03835	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FED53_RS03870	COG2003	Belongs to the UPF0758 family
FED53_RS03875	COG1077	Cell shape determining protein MreB Mrl
FED53_RS03880	COG1792	Involved in formation and maintenance of cell shape
FED53_RS03885	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FED53_RS03890	COG0850	regulation of cytokinetic process
FED53_RS03895	COG2894	cell division
FED53_RS03900	COG0739	heme binding
FED53_RS03905	COG1994	Peptidase M50
FED53_RS03910	COG1530	ribonuclease E activity
FED53_RS03920	COG2868	ribosomal protein
FED53_RS03925	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FED53_RS03930	COG3290	protein histidine kinase activity
FED53_RS03940	COG4492	Belongs to the UPF0735 family
FED53_RS03945	COG0077	Prephenate dehydratase
FED53_RS03950	COG1827	regulation of RNA biosynthetic process
FED53_RS03955	COG1104	cysteine desulfurase activity
FED53_RS03960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FED53_RS03965	COG0157	Belongs to the NadC ModD family
FED53_RS03970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FED53_RS03975	COG1388	LysM domain
FED53_RS03995	COG0632	four-way junction helicase activity
FED53_RS04010	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FED53_RS04015	COG0343	queuine tRNA-ribosyltransferase activity
FED53_RS04020	COG1862	Preprotein translocase
FED53_RS04030	COG2323	membrane
FED53_RS04035	COG2244	polysaccharide biosynthetic process
FED53_RS04045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FED53_RS04045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FED53_RS04050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FED53_RS04055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FED53_RS04055	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FED53_RS04060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FED53_RS04065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FED53_RS04075	COG4991	sh3 domain protein
FED53_RS04075	COG3103	Sh3 type 3 domain protein
FED53_RS04075	COG0860	N-Acetylmuramoyl-L-alanine amidase
FED53_RS04085	COG0124	histidyl-tRNA synthetase
FED53_RS04090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FED53_RS04100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FED53_RS04105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FED53_RS04110	COG1959	2 iron, 2 sulfur cluster binding
FED53_RS04115	COG1104	cysteine desulfurase activity
FED53_RS04120	COG0482	sulfurtransferase activity
FED53_RS04130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FED53_RS04145	COG0628	permease
FED53_RS04150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FED53_RS04155	COG4472	Bacterial protein of unknown function (DUF965)
FED53_RS04165	COG3906	Belongs to the UPF0473 family
FED53_RS04170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FED53_RS04175	COG4122	O-methyltransferase activity
FED53_RS04180	COG0826	peptidase U32
FED53_RS04185	COG0826	peptidase U32
FED53_RS04190	COG0572	uridine kinase
FED53_RS04195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FED53_RS04200	COG0768	penicillin binding
FED53_RS04215	COG2226	methyltransferase
FED53_RS04220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FED53_RS04225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FED53_RS04230	COG0626	cystathionine gamma-synthase activity
FED53_RS04245	COG1183	phosphatidylcholine synthase activity
FED53_RS04255	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FED53_RS04260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FED53_RS04265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FED53_RS04270	COG1534	Rna-binding protein
FED53_RS04275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FED53_RS04280	COG1713	HD superfamily hydrolase involved in NAD metabolism
FED53_RS04285	COG0799	negative regulation of ribosome biogenesis
FED53_RS04290	COG2226	methyltransferase
FED53_RS04295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FED53_RS04300	COG1555	photosystem II stabilization
FED53_RS04300	COG1596	polysaccharide export
FED53_RS04305	COG2131	deaminase
FED53_RS04310	COG0658	competence protein
FED53_RS04310	COG2333	competence protein COMEC
FED53_RS04320	COG1466	dna polymerase III delta subunit
FED53_RS04325	COG0268	Binds directly to 16S ribosomal RNA
FED53_RS04330	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FED53_RS04340	COG0481	GTPase activity
FED53_RS04345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FED53_RS04355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FED53_RS04360	COG0443	Heat shock 70 kDa protein
FED53_RS04365	COG0484	heat shock protein binding
FED53_RS04370	COG2264	protein methyltransferase activity
FED53_RS04375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FED53_RS04380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FED53_RS04390	COG1610	YqeY-like protein
FED53_RS04395	COG1030	water channel activity
FED53_RS04420	COG1702	phosphate starvation-inducible protein PhoH
FED53_RS04425	COG1480	7TM receptor with intracellular HD hydrolase
FED53_RS04435	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FED53_RS04440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FED53_RS04450	COG1381	Involved in DNA repair and RecF pathway recombination
FED53_RS04455	COG0517	IMP dehydrogenase activity
FED53_RS04460	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FED53_RS04465	COG1671	Belongs to the UPF0178 family
FED53_RS04470	COG0358	DNA primase activity
FED53_RS04475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FED53_RS04480	COG1960	acyl-CoA dehydrogenase activity
FED53_RS04490	COG2384	SAM-dependent methyltransferase
FED53_RS04495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FED53_RS04500	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FED53_RS04510	COG0513	Belongs to the DEAD box helicase family
FED53_RS04525	COG1121	(ABC) transporter
FED53_RS04530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FED53_RS04535	COG0735	belongs to the Fur family
FED53_RS04540	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
FED53_RS04545	COG4709	membrane
FED53_RS04550	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FED53_RS04560	COG2814	Major facilitator Superfamily
FED53_RS04580	COG2839	Protein conserved in bacteria
FED53_RS04615	COG0477	Major facilitator Superfamily
FED53_RS04620	COG0768	penicillin binding
FED53_RS04625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FED53_RS04630	COG0573	inorganic phosphate transmembrane transporter activity
FED53_RS04635	COG0581	inorganic phosphate transmembrane transporter activity
FED53_RS04645	COG0704	Plays a role in the regulation of phosphate uptake
FED53_RS04670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FED53_RS04680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FED53_RS04690	COG0457	Tetratricopeptide repeat
FED53_RS04690	COG0705	Rhomboid family
FED53_RS04695	COG4483	Protein conserved in bacteria
FED53_RS04700	COG1940	carbohydrate kinase activity
FED53_RS04705	COG1368	sulfuric ester hydrolase activity
FED53_RS04720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FED53_RS04730	COG1393	Belongs to the ArsC family
FED53_RS04735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FED53_RS04740	COG1459	type II secretion system
FED53_RS04745	COG4537	Required for transformation and DNA binding
FED53_RS04750	COG4970	Tfp pilus assembly protein FimT
FED53_RS04785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FED53_RS04790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FED53_RS04800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FED53_RS04805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FED53_RS04810	COG0095	Lipoate-protein ligase
FED53_RS04815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FED53_RS04820	COG1321	iron dependent repressor
FED53_RS04825	COG1752	Esterase of the alpha-beta hydrolase superfamily
FED53_RS04835	COG3872	metal-dependent enzyme
FED53_RS04845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FED53_RS04850	COG0006	proline dipeptidase activity
FED53_RS04855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FED53_RS04865	COG3854	ATPases associated with a variety of cellular activities
FED53_RS04905	COG0511	ligase activity, forming carbon-carbon bonds
FED53_RS04910	COG0439	Biotin carboxylase
FED53_RS04915	COG1302	Protein conserved in bacteria
FED53_RS04920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FED53_RS04930	COG1722	exodeoxyribonuclease VII activity
FED53_RS04945	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FED53_RS04955	COG0497	DNA recombination
FED53_RS04960	COG0750	zinc metalloprotease
FED53_RS04965	COG0745	RESPONSE REGULATOR receiver
FED53_RS04975	COG1620	l-lactate permease
FED53_RS04980	COG0039	L-malate dehydrogenase activity
FED53_RS04985	COG3093	addiction module antidote protein HigA
FED53_RS04990	COG0584	glycerophosphoryl diester phosphodiesterase
FED53_RS05000	COG3290	protein histidine kinase activity
FED53_RS05000	COG3829	transcription factor binding
FED53_RS05005	COG0280	phosphate acetyltransferase
FED53_RS05020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FED53_RS05025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FED53_RS05030	COG0022	dehydrogenase e1 component
FED53_RS05035	COG0508	dehydrogenase complex catalyzes the overall conversion of
FED53_RS05040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FED53_RS05040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FED53_RS05045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FED53_RS05045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FED53_RS05060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FED53_RS05065	COG0765	amino acid transport
FED53_RS05070	COG1126	abc transporter atp-binding protein
FED53_RS05075	COG4129	membrane
FED53_RS05080	COG1376	ErfK ybiS ycfS ynhG family protein
FED53_RS05085	COG0346	lactoylglutathione lyase activity
FED53_RS05090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FED53_RS05095	COG2195	Cleaves the N-terminal amino acid of tripeptides
FED53_RS05100	COG0493	'glutamate synthase
FED53_RS05130	COG2508	Transcriptional regulator
FED53_RS05135	COG1012	belongs to the aldehyde dehydrogenase family
FED53_RS05140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FED53_RS05145	COG1234	tRNA 3'-trailer cleavage
FED53_RS05150	COG1902	pentaerythritol trinitrate reductase activity
FED53_RS05155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FED53_RS05160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FED53_RS05165	COG0300	oxidoreductase activity
FED53_RS05180	COG4918	Iron-sulphur cluster biosynthesis
FED53_RS05185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FED53_RS05195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FED53_RS05200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FED53_RS05210	COG0667	Aldo Keto reductase
FED53_RS05220	COG0494	nUDIX hydrolase
FED53_RS05225	COG1300	Membrane
FED53_RS05230	COG0735	belongs to the Fur family
FED53_RS05245	COG4974	Belongs to the 'phage' integrase family
FED53_RS05265	COG1686	Belongs to the peptidase S11 family
FED53_RS05300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FED53_RS05315	COG0697	spore germination
FED53_RS05320	COG0019	diaminopimelate decarboxylase activity
FED53_RS05325	COG4086	secreted protein
FED53_RS05330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FED53_RS05340	COG1547	Domain of unknown function (DUF309)
FED53_RS05355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FED53_RS05360	COG1686	Belongs to the peptidase S11 family
FED53_RS05365	COG2715	membrane protein required for spore maturation
FED53_RS05370	COG0700	Nucleoside recognition
FED53_RS05375	COG1187	pseudouridine synthase activity
FED53_RS05380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FED53_RS05385	COG1333	cytochrome c biogenesis protein
FED53_RS05390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FED53_RS05395	COG0745	RESPONSE REGULATOR receiver
FED53_RS05400	COG5002	protein histidine kinase activity
FED53_RS05405	COG0739	heme binding
FED53_RS05410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FED53_RS05415	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FED53_RS05430	COG0514	ATP-dependent DNA helicase (RecQ)
FED53_RS05445	COG1408	metallophosphoesterase
FED53_RS05450	COG0789	Transcriptional regulator
FED53_RS05460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FED53_RS05465	COG0492	ferredoxin-NADP+ reductase activity
FED53_RS05470	COG0252	asparaginase activity
FED53_RS05475	COG2339	peptidase activity
FED53_RS05480	COG3773	Cell wall hydrolase
FED53_RS05480	COG3409	Peptidoglycan-binding domain 1 protein
FED53_RS05485	COG2959	enzyme of heme biosynthesis
FED53_RS05495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FED53_RS05505	COG0539	negative regulation of cytoplasmic translation
FED53_RS05510	COG1304	FMN binding
FED53_RS05515	COG2271	Major facilitator Superfamily
FED53_RS05535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FED53_RS05555	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FED53_RS05560	COG0776	regulation of translation
FED53_RS05565	COG0302	gtp cyclohydrolase
FED53_RS05575	COG0142	geranyltranstransferase activity
FED53_RS05580	COG2226	methyltransferase
FED53_RS05585	COG0142	geranyltranstransferase activity
FED53_RS05590	COG0105	UTP biosynthetic process
FED53_RS05595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FED53_RS05600	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FED53_RS05605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FED53_RS05615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FED53_RS05620	COG0134	indole-3-glycerol-phosphate synthase activity
FED53_RS05625	COG0135	phosphoribosylanthranilate isomerase activity
FED53_RS05630	COG0133	tryptophan synthase activity
FED53_RS05635	COG0159	tryptophan synthase activity
FED53_RS05640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FED53_RS05645	COG0287	Prephenate dehydrogenase
FED53_RS05650	COG0457	Tetratricopeptide repeat
FED53_RS05655	COG5582	Belongs to the UPF0302 family
FED53_RS05670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FED53_RS05680	COG4347	Protein of unknown function (DUF1405)
FED53_RS05700	COG3679	Belongs to the UPF0342 family
FED53_RS05720	COG0742	ribosomal rna small subunit methyltransferase
FED53_RS05725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FED53_RS05730	COG3314	Sporulation integral membrane protein YlbJ
FED53_RS05735	COG1752	Esterase of the alpha-beta hydrolase superfamily
FED53_RS05740	COG3480	Lon protease (S16) C-terminal proteolytic domain
FED53_RS05745	COG1323	Belongs to the UPF0348 family
FED53_RS05750	COG1399	metal-binding, possibly nucleic acid-binding protein
FED53_RS05755	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FED53_RS05760	COG1024	Enoyl-CoA hydratase
FED53_RS05770	COG0454	-acetyltransferase
FED53_RS05775	COG0439	Biotin carboxylase
FED53_RS05780	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FED53_RS05785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FED53_RS05790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FED53_RS05800	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FED53_RS05810	COG4839	cell division protein FtsL
FED53_RS05815	COG0768	penicillin binding
FED53_RS05820	COG0768	penicillin binding
FED53_RS05830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FED53_RS05835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FED53_RS05840	COG0772	Belongs to the SEDS family
FED53_RS05845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FED53_RS05850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FED53_RS05855	COG0849	cell division
FED53_RS05860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FED53_RS05870	COG1191	sigma factor activity
FED53_RS05875	COG1191	sigma factor activity
FED53_RS05880	COG1873	PFAM PRC-barrel domain
FED53_RS05885	COG1496	oxidoreductase activity
FED53_RS05890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FED53_RS05895	COG1799	cell septum assembly
FED53_RS05900	COG0762	integral membrane protein
FED53_RS05905	COG2302	S4 RNA-binding domain
FED53_RS05910	COG3599	regulation of cell shape
FED53_RS05925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FED53_RS05930	COG0564	pseudouridine synthase activity
FED53_RS05935	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FED53_RS05940	COG2233	PERMEase
FED53_RS05945	COG0540	Belongs to the ATCase OTCase family
FED53_RS05950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FED53_RS05970	COG0167	dihydroorotate dehydrogenase activity
FED53_RS05980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FED53_RS05990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FED53_RS05995	COG1561	YicC-like family, N-terminal region
FED53_RS06000	COG2052	Domain of unknown function (DUF370)
FED53_RS06005	COG0194	GDP metabolic process
FED53_RS06015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FED53_RS06020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FED53_RS06025	COG0242	peptide deformylase activity
FED53_RS06030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FED53_RS06035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FED53_RS06035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FED53_RS06045	COG0631	protein serine/threonine phosphatase activity
FED53_RS06050	COG2815	serine threonine protein kinase
FED53_RS06050	COG0515	serine threonine protein kinase
FED53_RS06060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FED53_RS06065	COG1564	THIamine pyrophosphokinase
FED53_RS06075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FED53_RS06080	COG1302	Protein conserved in bacteria
FED53_RS06085	COG1461	Dihydroxyacetone kinase
FED53_RS06095	COG1760	l-serine dehydratase
FED53_RS06100	COG1760	l-serine dehydratase
FED53_RS06105	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FED53_RS06110	COG1349	DNA-binding transcription factor activity
FED53_RS06115	COG0416	fatty acid biosynthetic process
FED53_RS06120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FED53_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS06135	COG0571	ribonuclease III activity
FED53_RS06140	COG1196	nuclear chromosome segregation
FED53_RS06145	COG0552	protein localization to endoplasmic reticulum
FED53_RS06155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FED53_RS06160	COG0228	four-way junction DNA binding
FED53_RS06165	COG1837	Belongs to the UPF0109 family
FED53_RS06175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FED53_RS06180	COG0336	Belongs to the RNA methyltransferase TrmD family
FED53_RS06185	COG0335	large ribosomal subunit rRNA binding
FED53_RS06200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FED53_RS06210	COG2257	FlhB HrpN YscU SpaS Family
FED53_RS06220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FED53_RS06225	COG0758	DNA mediated transformation
FED53_RS06230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FED53_RS06240	COG4974	Belongs to the 'phage' integrase family
FED53_RS06250	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FED53_RS06255	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FED53_RS06260	COG1815	bacterial-type flagellum-dependent cell motility
FED53_RS06265	COG1558	bacterial-type flagellum-dependent cell motility
FED53_RS06270	COG1677	Flagellar hook-basal body complex protein FliE
FED53_RS06275	COG1766	The M ring may be actively involved in energy transduction
FED53_RS06280	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FED53_RS06285	COG1317	bacterial-type flagellum organization
FED53_RS06290	COG1157	protein secretion by the type III secretion system
FED53_RS06295	COG2882	bacterial-type flagellum organization
FED53_RS06310	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FED53_RS06315	COG4786	Flagellar basal body rod
FED53_RS06320	COG1582	Flagellar protein (FlbD)
FED53_RS06325	COG1580	Controls the rotational direction of flagella during chemotaxis
FED53_RS06330	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FED53_RS06335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FED53_RS06335	COG1776	CheC inhibitor of MCP methylation
FED53_RS06340	COG2201	protein-glutamate methylesterase activity
FED53_RS06345	COG3190	flagellar
FED53_RS06350	COG1338	Plays a role in the flagellum-specific transport system
FED53_RS06355	COG1987	bacterial-type flagellum assembly
FED53_RS06360	COG1684	flagellar biosynthetic protein fliR
FED53_RS06365	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FED53_RS06370	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FED53_RS06375	COG1419	protein localization to endoplasmic reticulum
FED53_RS06380	COG0455	bacterial-type flagellum organization
FED53_RS06385	COG2201	protein-glutamate methylesterase activity
FED53_RS06390	COG0643	Histidine kinase
FED53_RS06390	COG2198	Histidine kinase
FED53_RS06395	COG0835	chemotaxis
FED53_RS06400	COG1776	CheC inhibitor of MCP methylation
FED53_RS06405	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FED53_RS06410	COG1191	sigma factor activity
FED53_RS06425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FED53_RS06435	COG0233	cytoplasmic translational termination
FED53_RS06445	COG4589	Belongs to the CDS family
FED53_RS06455	COG0750	zinc metalloprotease
FED53_RS06460	COG0442	prolyl-tRNA aminoacylation
FED53_RS06465	COG2176	DNA-directed DNA polymerase activity
FED53_RS06490	COG0779	Required for maturation of 30S ribosomal subunits
FED53_RS06495	COG0195	Participates in both transcription termination and antitermination
FED53_RS06500	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FED53_RS06505	COG1358	cellular component organization or biogenesis
FED53_RS06510	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FED53_RS06515	COG1550	Protein conserved in bacteria
FED53_RS06520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FED53_RS06530	COG0196	riboflavin kinase activity
FED53_RS06535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FED53_RS06540	COG1185	polyribonucleotide nucleotidyltransferase activity
FED53_RS06545	COG0726	polysaccharide deacetylase
FED53_RS06550	COG0612	Peptidase, M16
FED53_RS06555	COG1873	PFAM PRC-barrel domain
FED53_RS06560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FED53_RS06565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FED53_RS06570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FED53_RS06575	COG0527	aspartate kinase activity
FED53_RS06585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FED53_RS06590	COG0740	serine-type endopeptidase activity
FED53_RS06600	COG1674	ftsk spoiiie
FED53_RS06600	COG4980	gas vesicle protein
FED53_RS06605	COG2188	Transcriptional regulator
FED53_RS06610	COG1744	ABC transporter substrate-binding protein PnrA-like
FED53_RS06615	COG3845	ABC transporter
FED53_RS06620	COG4603	Belongs to the binding-protein-dependent transport system permease family
FED53_RS06625	COG1079	Belongs to the binding-protein-dependent transport system permease family
FED53_RS06630	COG0612	Peptidase, M16
FED53_RS06635	COG0612	Peptidase, M16
FED53_RS06640	COG0300	oxidoreductase activity
FED53_RS06655	COG1426	Protein conserved in bacteria
FED53_RS06660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FED53_RS06665	COG1058	Belongs to the CinA family
FED53_RS06665	COG1546	Belongs to the CinA family
FED53_RS06680	COG1692	metallophosphoesterase
FED53_RS06685	COG2359	stage V sporulation protein S
FED53_RS06695	COG0674	pyruvate-flavodoxin oxidoreductase activity
FED53_RS06695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FED53_RS06700	COG1013	pyruvate-flavodoxin oxidoreductase activity
FED53_RS06710	COG0156	8-amino-7-oxononanoate synthase activity
FED53_RS06715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FED53_RS06720	COG4550	Control of competence regulator ComK, YlbF/YmcA
FED53_RS06730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FED53_RS06745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FED53_RS06755	COG0464	growth
FED53_RS06760	COG2860	membrane
FED53_RS06765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FED53_RS06770	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FED53_RS06775	COG0789	Transcriptional regulator
FED53_RS06780	COG0174	glutamine synthetase
FED53_RS06785	COG4974	Belongs to the 'phage' integrase family
FED53_RS06790	COG2856	Zn peptidase
FED53_RS06810	COG1396	sequence-specific DNA binding
FED53_RS06900	COG0582	viral genome integration into host DNA
FED53_RS07020	COG3409	Peptidoglycan-binding domain 1 protein
FED53_RS07020	COG5632	N-Acetylmuramoyl-L-alanine amidase
FED53_RS07020	COG1388	LysM domain
FED53_RS07080	COG0531	amino acid
FED53_RS07085	COG1846	Transcriptional regulator
FED53_RS07090	COG0456	acetyltransferase
FED53_RS07095	COG2808	Putative FMN-binding domain
FED53_RS07110	COG1078	dGTPase activity
FED53_RS07115	COG0662	Cupin 2, conserved barrel domain protein
FED53_RS07120	COG2814	Major facilitator Superfamily
FED53_RS07130	COG0531	amino acid
FED53_RS07145	COG0659	secondary active sulfate transmembrane transporter activity
FED53_RS07145	COG0659	secondary active sulfate transmembrane transporter activity
FED53_RS07180	COG5632	N-Acetylmuramoyl-L-alanine amidase
FED53_RS07180	COG3409	Peptidoglycan-binding domain 1 protein
FED53_RS07190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FED53_RS07200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FED53_RS07205	COG4224	UPF0291 protein
FED53_RS07220	COG3763	UPF0154 protein
FED53_RS07225	COG1132	(ABC) transporter
FED53_RS07230	COG1132	(ABC) transporter
FED53_RS07240	COG0785	Cytochrome C biogenesis protein
FED53_RS07245	COG2201	protein-glutamate methylesterase activity
FED53_RS07250	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FED53_RS07255	COG4846	Membrane protein involved in cytochrome C biogenesis
FED53_RS07265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FED53_RS07275	COG0531	amino acid
FED53_RS07280	COG1012	belongs to the aldehyde dehydrogenase family
FED53_RS07285	COG1966	Carbon starvation protein
FED53_RS07300	COG5002	protein histidine kinase activity
FED53_RS07315	COG3142	Participates in the control of copper homeostasis
FED53_RS07325	COG0076	glutamate decarboxylase activity
FED53_RS07360	COG0788	formyltetrahydrofolate deformylase activity
FED53_RS07365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FED53_RS07370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FED53_RS07385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FED53_RS07395	COG1307	EDD domain protein, DegV family
FED53_RS07400	COG5002	protein histidine kinase activity
FED53_RS07405	COG1999	signal sequence binding
FED53_RS07410	COG2755	lipolytic protein G-D-S-L family
FED53_RS07435	COG4191	Histidine kinase
FED53_RS07445	COG0577	efflux transmembrane transporter activity
FED53_RS07450	COG1136	(ABC) transporter
FED53_RS07455	COG2205	protein histidine kinase activity
FED53_RS07460	COG0745	RESPONSE REGULATOR receiver
FED53_RS07465	COG1301	dicarboxylic acid transport
FED53_RS07470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FED53_RS07475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FED53_RS07480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FED53_RS07485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FED53_RS07495	COG1509	lysine 2,3-aminomutase activity
FED53_RS07510	COG3594	Acyltransferase
FED53_RS07540	COG0515	serine threonine protein kinase
FED53_RS07545	COG4326	sporulation control protein
FED53_RS07550	COG0671	phosphoesterase, PA-phosphatase related
FED53_RS07560	COG0813	purine-nucleoside phosphorylase activity
FED53_RS07565	COG0659	secondary active sulfate transmembrane transporter activity
FED53_RS07575	COG0772	Belongs to the SEDS family
FED53_RS07590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FED53_RS07595	COG2190	(PTS) system
FED53_RS07600	COG3711	transcriptional antiterminator
FED53_RS07605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FED53_RS07605	COG1263	PTS System
FED53_RS07610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FED53_RS07620	COG0706	membrane insertase activity
FED53_RS07630	COG0456	acetyltransferase
FED53_RS07635	COG4555	ABC transporter
FED53_RS07645	COG0584	glycerophosphoryl diester phosphodiesterase
FED53_RS07695	COG0432	Pfam Uncharacterised protein family UPF0047
FED53_RS07700	COG0791	NLP P60 protein
FED53_RS07700	COG1388	LysM domain
FED53_RS07705	COG0205	6-phosphofructokinase activity
FED53_RS07710	COG0589	response to stress
FED53_RS07715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FED53_RS07725	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FED53_RS07730	COG1253	flavin adenine dinucleotide binding
FED53_RS07735	COG2340	Cysteine-rich secretory protein family
FED53_RS07740	COG0668	transmembrane transport
FED53_RS07745	COG2323	membrane
FED53_RS07755	COG2514	catechol 2,3-dioxygenase activity
FED53_RS07770	COG2205	protein histidine kinase activity
FED53_RS07775	COG1609	Transcriptional regulator
FED53_RS07795	COG0395	ABC-type sugar transport system, permease component
FED53_RS07800	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FED53_RS07805	COG1737	Transcriptional regulator
FED53_RS07820	COG3876	Protein conserved in bacteria
FED53_RS07825	COG1472	Belongs to the glycosyl hydrolase 3 family
FED53_RS07830	COG1309	transcriptional regulator
FED53_RS07835	COG2814	Major facilitator Superfamily
FED53_RS07855	COG1125	glycine betaine transport
FED53_RS07855	COG0517	IMP dehydrogenase activity
FED53_RS07860	COG1174	glycine betaine transport
FED53_RS07880	COG0006	proline dipeptidase activity
FED53_RS07905	COG0789	Transcriptional regulator
FED53_RS07910	COG1607	acyl-coa hydrolase
FED53_RS07915	COG2247	cell wall binding repeat
FED53_RS07915	COG2385	sporulation resulting in formation of a cellular spore
FED53_RS07920	COG2205	protein histidine kinase activity
FED53_RS07920	COG2770	Histidine kinase
FED53_RS07925	COG0745	RESPONSE REGULATOR receiver
FED53_RS07930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FED53_RS07940	COG1522	sequence-specific DNA binding
FED53_RS07945	COG0569	domain protein
FED53_RS07950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FED53_RS07955	COG1404	Belongs to the peptidase S8 family
FED53_RS07960	COG0840	transmembrane signaling receptor activity
FED53_RS07965	COG1388	LysM domain
FED53_RS07965	COG0791	NLP P60 protein
FED53_RS07990	COG1216	Glycosyl transferase, family 2
FED53_RS07995	COG2259	Doxx family
FED53_RS08010	COG4980	gas vesicle protein
FED53_RS08015	COG1621	beta-fructofuranosidase activity
FED53_RS08020	COG1764	response to oxidative stress
FED53_RS08035	COG0454	-acetyltransferase
FED53_RS08040	COG2814	Major facilitator Superfamily
FED53_RS08050	COG4195	phage-related replication protein
FED53_RS08055	COG3226	Transcriptional regulator
FED53_RS08065	COG0861	Integral membrane protein TerC family
FED53_RS08070	COG2755	lipolytic protein G-D-S-L family
FED53_RS08070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FED53_RS08085	COG0561	phosphatase activity
FED53_RS08115	COG1937	Protein conserved in bacteria
FED53_RS08120	COG2608	mercury ion transmembrane transporter activity
FED53_RS08125	COG2217	Heavy metal translocating P-type atpase
FED53_RS08130	COG0346	lactoylglutathione lyase activity
FED53_RS08140	COG4948	Mandelate Racemase Muconate Lactonizing
FED53_RS08175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FED53_RS08180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FED53_RS08200	COG4335	DNA alkylation repair
FED53_RS08205	COG1187	pseudouridine synthase activity
FED53_RS08220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FED53_RS08225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FED53_RS08230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FED53_RS08235	COG1120	ATPase activity
FED53_RS08240	COG0492	ferredoxin-NADP+ reductase activity
FED53_RS08250	COG1114	Component of the transport system for branched-chain amino acids
FED53_RS08260	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FED53_RS08270	COG0640	Transcriptional regulator
FED53_RS08280	COG0405	Gamma-glutamyltransferase
FED53_RS08285	COG1253	flavin adenine dinucleotide binding
FED53_RS08300	COG0024	Methionine aminopeptidase
FED53_RS08310	COG0346	lactoylglutathione lyase activity
FED53_RS08315	COG2807	transmembrane transport
FED53_RS08320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FED53_RS08325	COG1609	Transcriptional regulator
FED53_RS08335	COG2814	Major facilitator Superfamily
FED53_RS08345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FED53_RS08350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FED53_RS08355	COG3695	enzyme binding
FED53_RS08365	COG2198	Histidine kinase
FED53_RS08365	COG0784	Response regulator, receiver
FED53_RS08365	COG5002	protein histidine kinase activity
FED53_RS08370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FED53_RS08375	COG2208	phosphoserine phosphatase activity
FED53_RS08385	COG1609	Transcriptional regulator
FED53_RS08390	COG2211	Major facilitator Superfamily
FED53_RS08415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FED53_RS08440	COG2244	polysaccharide biosynthetic process
FED53_RS08470	COG1609	Transcriptional regulator
FED53_RS08475	COG1012	belongs to the aldehyde dehydrogenase family
FED53_RS08480	COG1454	alcohol dehydrogenase
FED53_RS08540	COG1309	transcriptional regulator
FED53_RS08545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FED53_RS08555	COG1846	Transcriptional regulator
FED53_RS08560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FED53_RS08580	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS08585	COG0371	Dehydrogenase
FED53_RS08600	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FED53_RS08605	COG0667	Aldo Keto reductase
FED53_RS08615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FED53_RS08625	COG2186	Transcriptional regulator
FED53_RS08650	COG1278	Cold shock
FED53_RS08655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FED53_RS08660	COG2076	Multidrug Resistance protein
FED53_RS08685	COG1742	UPF0060 membrane protein
FED53_RS08690	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
FED53_RS08705	COG0456	acetyltransferase
FED53_RS08715	COG1464	Belongs to the NlpA lipoprotein family
FED53_RS08725	COG2011	ABC-type metal ion transport system permease component
FED53_RS08730	COG0039	L-malate dehydrogenase activity
FED53_RS08760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FED53_RS08765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FED53_RS08785	COG5566	PFAM Mor transcription activator
FED53_RS08820	COG2357	RelA SpoT domain protein
FED53_RS08830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FED53_RS08835	COG0730	response to heat
FED53_RS08840	COG3764	Sortase (surface protein transpeptidase)
FED53_RS08855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FED53_RS08870	COG1937	Protein conserved in bacteria
FED53_RS08885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FED53_RS08895	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FED53_RS08920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FED53_RS08925	COG1316	TRANSCRIPTIONal
FED53_RS08945	COG2814	Major facilitator Superfamily
FED53_RS08955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FED53_RS08960	COG1902	pentaerythritol trinitrate reductase activity
FED53_RS08985	COG0583	DNA-binding transcription factor activity
FED53_RS08990	COG0372	Belongs to the citrate synthase family
FED53_RS08995	COG2855	membrane
FED53_RS09005	COG1597	lipid kinase activity
FED53_RS09025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FED53_RS09040	COG2318	DinB family
FED53_RS09045	COG0733	neurotransmitter:sodium symporter activity
FED53_RS09050	COG2002	toxin-antitoxin pair type II binding
FED53_RS09055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FED53_RS09065	COG4991	sh3 domain protein
FED53_RS09065	COG3103	Sh3 type 3 domain protein
FED53_RS09065	COG0860	N-Acetylmuramoyl-L-alanine amidase
FED53_RS09090	COG0640	Transcriptional regulator
FED53_RS09115	COG1902	pentaerythritol trinitrate reductase activity
FED53_RS09160	COG0733	neurotransmitter:sodium symporter activity
FED53_RS09170	COG0753	catalase activity
FED53_RS09175	COG1388	LysM domain
FED53_RS09175	COG0791	NLP P60 protein
FED53_RS09180	COG0011	TIGRFAM Protein of
FED53_RS09185	COG2508	Transcriptional regulator
FED53_RS09195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FED53_RS09200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FED53_RS09210	COG2059	Chromate
FED53_RS09215	COG2059	Chromate
FED53_RS09220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FED53_RS09220	COG1605	Chorismate mutase
FED53_RS09230	COG0287	Prephenate dehydrogenase
FED53_RS09245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FED53_RS09245	COG0723	plastoquinol--plastocyanin reductase activity
FED53_RS09260	COG0517	IMP dehydrogenase activity
FED53_RS09260	COG0516	GMP reductase activity
FED53_RS09270	COG1695	Transcriptional regulator
FED53_RS09275	COG2059	Chromate
FED53_RS09285	COG1253	flavin adenine dinucleotide binding
FED53_RS09290	COG3878	Protein conserved in bacteria
FED53_RS09295	COG5577	PFAM Coat F domain
FED53_RS09305	COG0783	Belongs to the Dps family
FED53_RS09340	COG1132	(ABC) transporter
FED53_RS09355	COG5002	protein histidine kinase activity
FED53_RS09360	COG0745	RESPONSE REGULATOR receiver
FED53_RS09365	COG1469	GTP cyclohydrolase I activity
FED53_RS09370	COG2244	polysaccharide biosynthetic process
FED53_RS09375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FED53_RS09380	COG0400	carboxylic ester hydrolase activity
FED53_RS09395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FED53_RS09400	COG0778	Nitroreductase
FED53_RS09405	COG1388	LysM domain
FED53_RS09405	COG3584	3D domain protein
FED53_RS09425	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FED53_RS09435	COG0831	urea catabolic process
FED53_RS09440	COG0832	Belongs to the urease beta subunit family
FED53_RS09485	COG1301	dicarboxylic acid transport
FED53_RS09490	COG2404	hydrolase activity, acting on ester bonds
FED53_RS09495	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS09500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FED53_RS09505	COG1733	regulation of RNA biosynthetic process
FED53_RS09520	COG4145	pantothenate transmembrane transporter activity
FED53_RS09525	COG1492	cobalamin metabolic process
FED53_RS09530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FED53_RS09535	COG4604	ABC transporter, ATP-binding protein
FED53_RS09545	COG1960	acyl-CoA dehydrogenase activity
FED53_RS09560	COG1215	transferase activity, transferring glycosyl groups
FED53_RS09570	COG1086	Polysaccharide biosynthesis protein
FED53_RS09585	COG2182	Extracellular solute-binding protein
FED53_RS09590	COG1175	transmembrane transport
FED53_RS09595	COG3833	ABC-type maltose transport systems, permease component
FED53_RS09610	COG0438	transferase activity, transferring glycosyl groups
FED53_RS09615	COG1216	Glycosyl transferase, family 2
FED53_RS09630	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FED53_RS09630	COG0456	acetyltransferase
FED53_RS09670	COG2311	Membrane
FED53_RS09680	COG1764	response to oxidative stress
FED53_RS09685	COG0567	Dehydrogenase, E1 component
FED53_RS09690	COG0508	dehydrogenase complex catalyzes the overall conversion of
FED53_RS09710	COG4682	membrane
FED53_RS09720	COG1301	dicarboxylic acid transport
FED53_RS09740	COG2390	Transcriptional regulator
FED53_RS09750	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FED53_RS09755	COG0295	cytidine deaminase activity
FED53_RS09760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FED53_RS09770	COG2309	aminopeptidase activity
FED53_RS09810	COG1114	Component of the transport system for branched-chain amino acids
FED53_RS09820	COG1525	nuclease
FED53_RS09845	COG0673	inositol 2-dehydrogenase activity
FED53_RS09850	COG0673	inositol 2-dehydrogenase activity
FED53_RS09855	COG1082	Xylose isomerase domain protein TIM barrel
FED53_RS09860	COG2814	Major facilitator Superfamily
FED53_RS09870	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FED53_RS09885	COG0656	L-ascorbic acid biosynthetic process
FED53_RS09900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FED53_RS09920	COG0156	8-amino-7-oxononanoate synthase activity
FED53_RS09925	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FED53_RS09955	COG0601	transmembrane transport
FED53_RS09965	COG0444	Belongs to the ABC transporter superfamily
FED53_RS09970	COG4608	Belongs to the ABC transporter superfamily
FED53_RS09980	COG1396	sequence-specific DNA binding
FED53_RS09995	COG1280	lysine exporter protein (LysE YggA)
FED53_RS10000	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FED53_RS10035	COG0778	Nitroreductase
FED53_RS10040	COG0697	spore germination
FED53_RS10045	COG0747	negative chemotaxis
FED53_RS10060	COG1609	Transcriptional regulator
FED53_RS10065	COG1653	transport
FED53_RS10070	COG1175	transmembrane transport
FED53_RS10075	COG0395	ABC-type sugar transport system, permease component
FED53_RS10080	COG1486	melibiose metabolic process
FED53_RS10095	COG1070	Carbohydrate kinase
FED53_RS10100	COG0477	Major facilitator Superfamily
FED53_RS10100	COG2814	Major facilitator Superfamily
FED53_RS10110	COG2391	methyltransferase activity
FED53_RS10120	COG2814	Major facilitator Superfamily
FED53_RS10155	COG0346	lactoylglutathione lyase activity
FED53_RS10175	COG2188	Transcriptional regulator
FED53_RS10200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FED53_RS10205	COG1683	Conserved Protein
FED53_RS10210	COG2814	Major facilitator Superfamily
FED53_RS10215	COG0583	DNA-binding transcription factor activity
FED53_RS10230	COG0697	spore germination
FED53_RS10235	COG1917	Cupin 2, conserved barrel domain protein
FED53_RS10235	COG2207	Transcriptional regulator
FED53_RS10340	COG1193	negative regulation of DNA recombination
FED53_RS10355	COG1263	PTS System
FED53_RS10355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FED53_RS10380	COG0488	(ABC) transporter
FED53_RS10385	COG0697	spore germination
FED53_RS10390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FED53_RS10430	COG0561	phosphatase activity
FED53_RS10460	COG0456	acetyltransferase
FED53_RS10480	COG0656	L-ascorbic acid biosynthetic process
FED53_RS10490	COG2267	carboxylic ester hydrolase activity
FED53_RS10525	COG5444	nuclease activity
FED53_RS10535	COG5444	nuclease activity
FED53_RS10560	COG0617	tRNA 3'-terminal CCA addition
FED53_RS10590	COG1937	Protein conserved in bacteria
FED53_RS10595	COG0425	Belongs to the sulfur carrier protein TusA family
FED53_RS10600	COG2210	Belongs to the sulfur carrier protein TusA family
FED53_RS10605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FED53_RS10610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FED53_RS10610	COG0425	Belongs to the sulfur carrier protein TusA family
FED53_RS10615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FED53_RS10615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FED53_RS10620	COG0425	Belongs to the sulfur carrier protein TusA family
FED53_RS10625	COG0730	response to heat
FED53_RS10630	COG0109	protoheme IX farnesyltransferase activity
FED53_RS10635	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS10640	COG1309	transcriptional regulator
FED53_RS10645	COG1250	3-hydroxyacyl-CoA dehydrogenase
FED53_RS10655	COG1960	acyl-CoA dehydrogenase activity
FED53_RS10690	COG0393	Putative heavy-metal-binding
FED53_RS10710	COG3583	domain protein
FED53_RS10710	COG3584	3D domain protein
FED53_RS10720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FED53_RS10730	COG2723	6-phospho-beta-galactosidase activity
FED53_RS10765	COG0579	oxidoreductase
FED53_RS10780	COG1278	Cold shock
FED53_RS10805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FED53_RS10810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FED53_RS10815	COG0583	DNA-binding transcription factor activity
FED53_RS10825	COG0346	lactoylglutathione lyase activity
FED53_RS10925	COG0673	inositol 2-dehydrogenase activity
FED53_RS10930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FED53_RS10935	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FED53_RS10940	COG1733	regulation of RNA biosynthetic process
FED53_RS10945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FED53_RS10950	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FED53_RS10965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FED53_RS10980	COG1366	Belongs to the anti-sigma-factor antagonist family
FED53_RS10995	COG3973	AAA domain
FED53_RS11000	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS11005	COG3773	Cell wall hydrolase
FED53_RS11040	COG0534	Mate efflux family protein
FED53_RS11070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FED53_RS11080	COG1595	DNA-templated transcription, initiation
FED53_RS11085	COG0326	Molecular chaperone. Has ATPase activity
FED53_RS11095	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS11120	COG2124	cytochrome p450
FED53_RS11125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FED53_RS11135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FED53_RS11160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FED53_RS11165	COG2720	vancomycin resistance protein
FED53_RS11170	COG1846	Transcriptional regulator
FED53_RS11175	COG0318	PFAM AMP-dependent synthetase and ligase
FED53_RS11180	COG0702	epimerase
FED53_RS11185	COG0494	nUDIX hydrolase
FED53_RS11205	COG0456	acetyltransferase
FED53_RS11210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FED53_RS11210	COG3153	acetyltransferase
FED53_RS11220	COG3883	PFAM NLP P60 protein
FED53_RS11220	COG0791	NLP P60 protein
FED53_RS11225	COG1587	Uroporphyrinogen-III synthase
FED53_RS11230	COG1414	Transcriptional regulator
FED53_RS11235	COG0439	Biotin carboxylase
FED53_RS11240	COG0511	ligase activity, forming carbon-carbon bonds
FED53_RS11245	COG1984	allophanate hydrolase subunit 2
FED53_RS11250	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FED53_RS11255	COG4336	lyase activity
FED53_RS11260	COG1914	H( )-stimulated, divalent metal cation uptake system
FED53_RS11265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FED53_RS11270	COG0791	NLP P60 protein
FED53_RS11290	COG2197	response regulator
FED53_RS11295	COG4585	Histidine kinase
FED53_RS11295	COG2203	Gaf domain
FED53_RS11310	COG0129	dihydroxy-acid dehydratase activity
FED53_RS11315	COG1227	inorganic diphosphatase activity
FED53_RS11330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FED53_RS11340	COG2233	PERMEase
FED53_RS11355	COG1247	-acetyltransferase
FED53_RS11365	COG1011	Hydrolase
FED53_RS11380	COG4974	Belongs to the 'phage' integrase family
FED53_RS11405	COG1335	isochorismatase
FED53_RS11415	COG3403	YqcI/YcgG family
FED53_RS11420	COG2267	carboxylic ester hydrolase activity
FED53_RS11425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FED53_RS11430	COG0187	DNA topoisomerase II activity
FED53_RS11435	COG1832	CoA-binding protein
FED53_RS11440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FED53_RS11445	COG4841	protein insertion into membrane
FED53_RS11450	COG0824	Thioesterase
FED53_RS11475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FED53_RS11480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FED53_RS11505	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FED53_RS11540	COG2814	Major facilitator Superfamily
FED53_RS11545	COG1295	ribonuclease BN
FED53_RS11555	COG2814	Major facilitator Superfamily
FED53_RS11560	COG0789	Transcriptional regulator
FED53_RS11565	COG0659	secondary active sulfate transmembrane transporter activity
FED53_RS11570	COG0454	-acetyltransferase
FED53_RS11575	COG0745	RESPONSE REGULATOR receiver
FED53_RS11585	COG1247	-acetyltransferase
FED53_RS11605	COG0860	N-Acetylmuramoyl-L-alanine amidase
FED53_RS11610	COG5002	protein histidine kinase activity
FED53_RS11630	COG0004	ammonium transporteR
FED53_RS11645	COG1252	NADH dehydrogenase
FED53_RS11650	COG0402	S-adenosylhomocysteine deaminase activity
FED53_RS11660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FED53_RS11680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FED53_RS11695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FED53_RS11700	COG0438	transferase activity, transferring glycosyl groups
FED53_RS11715	COG0438	transferase activity, transferring glycosyl groups
FED53_RS11720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FED53_RS11755	COG0456	acetyltransferase
FED53_RS11760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FED53_RS11770	COG0586	Pfam SNARE associated Golgi protein
FED53_RS11775	COG0534	Mate efflux family protein
FED53_RS11780	COG1164	Oligoendopeptidase f
FED53_RS11785	COG0708	Exodeoxyribonuclease III
FED53_RS11790	COG0737	Belongs to the 5'-nucleotidase family
FED53_RS11805	COG1295	ribonuclease BN
FED53_RS11810	COG1834	amidinotransferase
FED53_RS11815	COG2409	Drug exporters of the RND superfamily
FED53_RS11840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FED53_RS11845	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FED53_RS11850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FED53_RS11880	COG3584	3D domain protein
FED53_RS11880	COG1388	LysM domain
FED53_RS11895	COG1846	Transcriptional regulator
FED53_RS11900	COG1764	response to oxidative stress
FED53_RS11925	COG1131	(ABC) transporter
FED53_RS11930	COG1725	Transcriptional regulator
FED53_RS11935	COG0583	DNA-binding transcription factor activity
FED53_RS11950	COG3546	catalase activity
FED53_RS11955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FED53_RS11960	COG1575	Belongs to the MenA family. Type 1 subfamily
FED53_RS11965	COG0514	ATP-dependent DNA helicase (RecQ)
FED53_RS11980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FED53_RS11990	COG0551	DNA topoisomerase type I activity
FED53_RS11990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FED53_RS12005	COG1070	Carbohydrate kinase
FED53_RS12030	COG1533	DNA photolyase activity
FED53_RS12040	COG1609	Transcriptional regulator
FED53_RS12050	COG1757	Na H antiporter
FED53_RS12055	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FED53_RS12060	COG1131	(ABC) transporter
FED53_RS12070	COG0488	(ABC) transporter
FED53_RS12080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FED53_RS12085	COG2378	regulation of single-species biofilm formation
FED53_RS12090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FED53_RS12100	COG2223	nitrite transmembrane transporter activity
FED53_RS12105	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS12110	COG3835	regulator
FED53_RS12115	COG0277	FAD linked oxidase domain protein
FED53_RS12120	COG0247	lactate metabolic process
FED53_RS12135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FED53_RS12140	COG1335	isochorismatase
FED53_RS12145	COG0494	nUDIX hydrolase
FED53_RS12155	COG1132	(ABC) transporter
FED53_RS12195	COG0297	glycogen (starch) synthase activity
FED53_RS12210	COG1396	sequence-specific DNA binding
FED53_RS12215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FED53_RS12220	COG0110	maltose O-acetyltransferase activity
FED53_RS12225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FED53_RS12235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FED53_RS12245	COG1215	transferase activity, transferring glycosyl groups
FED53_RS12250	COG0438	transferase activity, transferring glycosyl groups
FED53_RS12255	COG0438	transferase activity, transferring glycosyl groups
FED53_RS12260	COG1086	Polysaccharide biosynthesis protein
FED53_RS12265	COG0489	protein tyrosine kinase activity
FED53_RS12270	COG3944	biosynthesis protein
FED53_RS12295	COG2720	vancomycin resistance protein
FED53_RS12300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FED53_RS12325	COG1657	PFAM Prenyltransferase squalene oxidase
FED53_RS12330	COG1119	ATPase activity
FED53_RS12340	COG2207	Transcriptional regulator
FED53_RS12355	COG4548	von Willebrand factor, type A
FED53_RS12360	COG0714	Associated with various cellular activities
FED53_RS12365	COG4873	Protein conserved in bacteria
FED53_RS12370	COG1595	DNA-templated transcription, initiation
FED53_RS12390	COG3871	stress protein (general stress protein 26)
FED53_RS12395	COG0352	thiamine-phosphate diphosphorylase activity
FED53_RS12400	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FED53_RS12415	COG2094	Belongs to the DNA glycosylase MPG family
FED53_RS12425	COG0673	inositol 2-dehydrogenase activity
FED53_RS12430	COG0673	inositol 2-dehydrogenase activity
FED53_RS12445	COG3773	Cell wall hydrolase
FED53_RS12450	COG0733	neurotransmitter:sodium symporter activity
FED53_RS12470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FED53_RS12475	COG1012	belongs to the aldehyde dehydrogenase family
FED53_RS12510	COG2032	superoxide dismutase activity
FED53_RS12520	COG0527	aspartate kinase activity
FED53_RS12525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FED53_RS12525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FED53_RS12525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FED53_RS12530	COG1105	Belongs to the carbohydrate kinase PfkB family
FED53_RS12535	COG1349	DNA-binding transcription factor activity
FED53_RS12545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FED53_RS12565	COG0740	serine-type endopeptidase activity
FED53_RS12590	COG3485	protocatechuate 3,4-dioxygenase
FED53_RS12595	COG0183	Belongs to the thiolase family
FED53_RS12605	COG4948	Mandelate Racemase Muconate Lactonizing
FED53_RS12610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FED53_RS12615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FED53_RS12625	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FED53_RS12635	COG3485	protocatechuate 3,4-dioxygenase
FED53_RS12640	COG0196	riboflavin kinase activity
FED53_RS12690	COG2323	membrane
FED53_RS12695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FED53_RS12705	COG2323	membrane
FED53_RS12720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FED53_RS12750	COG5002	protein histidine kinase activity
FED53_RS12765	COG2246	polysaccharide biosynthetic process
FED53_RS12770	COG0463	Glycosyl transferase, family 2
FED53_RS12775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FED53_RS12780	COG3546	catalase activity
FED53_RS12800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FED53_RS12805	COG0628	permease
FED53_RS12810	COG1012	belongs to the aldehyde dehydrogenase family
FED53_RS12830	COG0493	'glutamate synthase
FED53_RS12835	COG0067	glutamate synthase
FED53_RS12835	COG0069	glutamate synthase activity
FED53_RS12835	COG0070	glutamate synthase
FED53_RS12840	COG0583	DNA-binding transcription factor activity
FED53_RS12855	COG1278	Cold shock
FED53_RS12865	COG3830	Belongs to the UPF0237 family
FED53_RS12870	COG2848	UPF0210 protein
FED53_RS12885	COG3402	PFAM membrane-flanked domain
FED53_RS12890	COG0281	malic enzyme
FED53_RS12895	COG1027	Aspartate ammonia-lyase
FED53_RS12900	COG1611	Belongs to the LOG family
FED53_RS12905	COG2323	membrane
FED53_RS12915	COG0561	phosphatase activity
FED53_RS12920	COG0281	malic enzyme
FED53_RS12930	COG3104	oligopeptide transport
FED53_RS12935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FED53_RS12940	COG5002	protein histidine kinase activity
FED53_RS12950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FED53_RS12960	COG1757	Na H antiporter
FED53_RS12965	COG3361	conserved protein (COG2071)
FED53_RS12975	COG1360	Flagellar Motor Protein
FED53_RS12980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FED53_RS12985	COG2112	serine threonine protein kinase
FED53_RS12990	COG2124	cytochrome p450
FED53_RS12990	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FED53_RS12995	COG1012	belongs to the aldehyde dehydrogenase family
FED53_RS13000	COG1823	symporter activity
FED53_RS13010	COG2234	aminopeptidase activity
FED53_RS13035	COG3853	Toxic anion resistance protein (TelA)
FED53_RS13045	COG1368	sulfuric ester hydrolase activity
FED53_RS13055	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS13060	COG0534	Mate efflux family protein
FED53_RS13065	COG2002	toxin-antitoxin pair type II binding
FED53_RS13080	COG3314	Sporulation integral membrane protein YlbJ
FED53_RS13095	COG3011	Protein conserved in bacteria
FED53_RS13100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FED53_RS13110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FED53_RS13115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FED53_RS13130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FED53_RS13145	COG2962	Rard protein
FED53_RS13150	COG2096	Adenosyltransferase
FED53_RS13160	COG0588	phosphoglycerate mutase activity
FED53_RS13165	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FED53_RS13180	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FED53_RS13190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FED53_RS13200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FED53_RS13215	COG2136	Putative SAM-dependent methyltransferase
FED53_RS13215	COG2521	methyltransferase
FED53_RS13235	COG1413	lyase activity
FED53_RS13240	COG0488	(ABC) transporter
FED53_RS13245	COG1418	mRNA catabolic process
FED53_RS13250	COG0386	Belongs to the glutathione peroxidase family
FED53_RS13265	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FED53_RS13280	COG2226	methyltransferase
FED53_RS13295	COG1940	carbohydrate kinase activity
FED53_RS13300	COG2182	Extracellular solute-binding protein
FED53_RS13315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FED53_RS13315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FED53_RS13320	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FED53_RS13320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FED53_RS13325	COG2814	Major facilitator Superfamily
FED53_RS13335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FED53_RS13345	COG0477	Major facilitator Superfamily
FED53_RS13350	COG1819	glycosyl
FED53_RS13370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FED53_RS13370	COG0551	DNA topoisomerase type I activity
FED53_RS13400	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS13450	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS13455	COG0561	phosphatase activity
FED53_RS13470	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FED53_RS13475	COG0640	Transcriptional regulator
FED53_RS13485	COG0640	Transcriptional regulator
FED53_RS13490	COG0346	lactoylglutathione lyase activity
FED53_RS13510	COG1595	DNA-templated transcription, initiation
FED53_RS13520	COG1522	sequence-specific DNA binding
FED53_RS13525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FED53_RS13530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FED53_RS13535	COG0655	NAD(P)H dehydrogenase (quinone) activity
FED53_RS13540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FED53_RS13555	COG1388	LysM domain
FED53_RS13560	COG0745	RESPONSE REGULATOR receiver
FED53_RS13565	COG5002	protein histidine kinase activity
FED53_RS13580	COG2814	Major facilitator Superfamily
FED53_RS13585	COG2197	response regulator
FED53_RS13590	COG4585	Histidine kinase
FED53_RS13595	COG3239	Fatty acid desaturase
FED53_RS13605	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FED53_RS13610	COG0701	Predicted permease
FED53_RS13630	COG4608	Belongs to the ABC transporter superfamily
FED53_RS13635	COG0791	NLP P60 protein
FED53_RS13640	COG1619	proteins homologs of microcin C7 resistance protein MccF
FED53_RS13645	COG4166	transmembrane transport
FED53_RS13650	COG0444	Belongs to the ABC transporter superfamily
FED53_RS13655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FED53_RS13660	COG0601	transmembrane transport
FED53_RS13665	COG2362	D-Aminopeptidase
FED53_RS13670	COG2233	PERMEase
FED53_RS13690	COG2814	Major facilitator Superfamily
FED53_RS13695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FED53_RS13715	COG0328	RNA-DNA hybrid ribonuclease activity
FED53_RS13720	COG0328	RNA-DNA hybrid ribonuclease activity
FED53_RS13750	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FED53_RS13755	COG1755	Isoprenylcysteine carboxyl methyltransferase
FED53_RS13760	COG3424	synthase
FED53_RS13770	COG2233	PERMEase
FED53_RS13775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FED53_RS13780	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FED53_RS13785	COG1199	ATP-dependent helicase activity
FED53_RS13800	COG0116	Belongs to the methyltransferase superfamily
FED53_RS13805	COG0366	Alpha amylase catalytic
FED53_RS13810	COG2197	response regulator
FED53_RS13815	COG4585	Histidine kinase
FED53_RS13840	COG3599	regulation of cell shape
FED53_RS13845	COG4474	Belongs to the UPF0398 family
FED53_RS13855	COG3359	exonuclease
FED53_RS13860	COG1205	dead DEAH box helicase
FED53_RS13860	COG1111	helicase
FED53_RS13870	COG1331	Highly conserved protein containing a thioredoxin domain
FED53_RS13885	COG4607	ABC-type enterochelin transport system periplasmic component
FED53_RS13890	COG4604	ABC transporter, ATP-binding protein
FED53_RS13895	COG4605	iron ion homeostasis
FED53_RS13900	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FED53_RS13910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FED53_RS13945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FED53_RS13960	COG0626	cystathionine gamma-synthase activity
FED53_RS13965	COG0626	cystathionine gamma-synthase activity
FED53_RS13970	COG5337	Spore coat protein CotH
FED53_RS14005	COG3331	DNA recombination
FED53_RS14010	COG4499	WXG100 protein secretion system (Wss), protein YukC
FED53_RS14010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FED53_RS14020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FED53_RS14025	COG3935	DnaD domain protein
FED53_RS14030	COG0017	Asparaginyl-tRNA synthetase
FED53_RS14035	COG0436	Aminotransferase
FED53_RS14055	COG1199	ATP-dependent helicase activity
FED53_RS14055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FED53_RS14060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FED53_RS14065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FED53_RS14070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FED53_RS14080	COG0617	tRNA 3'-terminal CCA addition
FED53_RS14085	COG0438	transferase activity, transferring glycosyl groups
FED53_RS14090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FED53_RS14095	COG1803	Methylglyoxal synthase
FED53_RS14100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FED53_RS14105	COG1694	Mazg nucleotide pyrophosphohydrolase
FED53_RS14110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FED53_RS14115	COG2738	Putative neutral zinc metallopeptidase
FED53_RS14125	COG2340	Cysteine-rich secretory protein family
FED53_RS14130	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
FED53_RS14140	COG3336	cytochrome c oxidase
FED53_RS14165	COG1612	heme a metabolic process
FED53_RS14170	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FED53_RS14175	COG0772	Belongs to the SEDS family
FED53_RS14180	COG4838	Belongs to the UPF0358 family
FED53_RS14185	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FED53_RS14190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FED53_RS14205	COG4896	Protein conserved in bacteria
FED53_RS14220	COG1217	gtp-binding protein TYPA
FED53_RS14230	COG0483	inositol monophosphate 1-phosphatase activity
FED53_RS14240	COG4493	Belongs to the UPF0637 family
FED53_RS14245	COG4476	Belongs to the UPF0223 family
FED53_RS14250	COG1982	Orn Lys Arg decarboxylase major
FED53_RS14265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FED53_RS14275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FED53_RS14280	COG0508	dehydrogenase complex catalyzes the overall conversion of
FED53_RS14285	COG0022	dehydrogenase e1 component
FED53_RS14305	COG0242	peptide deformylase activity
FED53_RS14310	COG0561	phosphatase activity
FED53_RS14320	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FED53_RS14335	COG1131	(ABC) transporter
FED53_RS14340	COG2197	response regulator
FED53_RS14345	COG4585	Histidine kinase
FED53_RS14350	COG0569	domain protein
FED53_RS14355	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FED53_RS14360	COG0450	alkyl hydroperoxide reductase
FED53_RS14365	COG0668	transmembrane transport
FED53_RS14370	COG1473	amidohydrolase
FED53_RS14375	COG2171	N-acyltransferase activity
FED53_RS14380	COG0583	DNA-binding transcription factor activity
FED53_RS14385	COG4703	Protein of unknown function (DUF1797)
FED53_RS14400	COG2200	EAL domain
FED53_RS14405	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS14410	COG1408	metallophosphoesterase
FED53_RS14425	COG0248	Ppx GppA phosphatase
FED53_RS14430	COG1376	ErfK ybiS ycfS ynhG family protein
FED53_RS14440	COG4975	Glucose uptake
FED53_RS14450	COG0835	chemotaxis
FED53_RS14450	COG0784	Response regulator, receiver
FED53_RS14465	COG0436	Aminotransferase
FED53_RS14470	COG2084	Dehydrogenase
FED53_RS14475	COG0778	Nitroreductase
FED53_RS14480	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS14490	COG0583	DNA-binding transcription factor activity
FED53_RS14495	COG1733	regulation of RNA biosynthetic process
FED53_RS14500	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FED53_RS14505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FED53_RS14515	COG1346	cytolysis
FED53_RS14530	COG1263	PTS System
FED53_RS14530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FED53_RS14530	COG2190	(PTS) system
FED53_RS14535	COG3711	transcriptional antiterminator
FED53_RS14545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FED53_RS14550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FED53_RS14550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FED53_RS14555	COG0307	riboflavin synthase, alpha
FED53_RS14560	COG3949	Membrane
FED53_RS14565	COG4989	oxidoreductase activity
FED53_RS14570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FED53_RS14570	COG0646	methionine synthase
FED53_RS14575	COG0646	methionine synthase
FED53_RS14575	COG1410	methionine synthase
FED53_RS14580	COG1966	Carbon starvation protein
FED53_RS14605	COG2031	fatty acid transporter
FED53_RS14615	COG5506	Protein of unknown function (DUF1694)
FED53_RS14620	COG3773	Cell wall hydrolase
FED53_RS14640	COG4873	Protein conserved in bacteria
FED53_RS14645	COG0702	epimerase
FED53_RS14650	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FED53_RS14655	COG0602	queuosine metabolic process
FED53_RS14660	COG0720	synthase
FED53_RS14665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FED53_RS14670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FED53_RS14685	COG0697	spore germination
FED53_RS14690	COG0300	oxidoreductase activity
FED53_RS14700	COG1757	Na H antiporter
FED53_RS14705	COG0542	response to heat
FED53_RS14720	COG1846	Transcriptional regulator
FED53_RS14745	COG1172	Belongs to the binding-protein-dependent transport system permease family
FED53_RS14750	COG1129	ABC transporter
FED53_RS14765	COG0235	Class ii aldolase
FED53_RS14770	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
FED53_RS14775	COG1850	ribulose-bisphosphate carboxylase activity
FED53_RS14780	COG0436	Aminotransferase
FED53_RS14785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FED53_RS14790	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
FED53_RS14795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FED53_RS14805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FED53_RS14810	COG5002	protein histidine kinase activity
FED53_RS14820	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FED53_RS14825	COG1032	radical SAM domain protein
FED53_RS14830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FED53_RS14865	COG0861	Integral membrane protein TerC family
FED53_RS14870	COG3279	Response regulator of the LytR AlgR family
FED53_RS14875	COG1785	Belongs to the alkaline phosphatase family
FED53_RS14895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FED53_RS14895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FED53_RS14900	COG0477	Major facilitator Superfamily
FED53_RS14905	COG1846	Transcriptional regulator
FED53_RS14920	COG2252	PERMEase
FED53_RS14960	COG0346	lactoylglutathione lyase activity
FED53_RS14965	COG1253	flavin adenine dinucleotide binding
FED53_RS14975	COG0737	Belongs to the 5'-nucleotidase family
FED53_RS14980	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FED53_RS14985	COG4988	ABC transporter
FED53_RS14990	COG1294	oxidase, subunit
FED53_RS14995	COG1271	oxidase subunit
FED53_RS15010	COG1131	(ABC) transporter
FED53_RS15035	COG1263	PTS System
FED53_RS15035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FED53_RS15035	COG2190	(PTS) system
FED53_RS15040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FED53_RS15045	COG0363	glucosamine-6-phosphate deaminase activity
FED53_RS15050	COG2188	Transcriptional regulator
FED53_RS15085	COG0561	phosphatase activity
FED53_RS15090	COG1609	Transcriptional regulator
FED53_RS15095	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FED53_RS15135	COG3314	Sporulation integral membrane protein YlbJ
FED53_RS15140	COG4948	Mandelate Racemase Muconate Lactonizing
FED53_RS15150	COG1737	Transcriptional regulator
FED53_RS15155	COG1473	amidohydrolase
FED53_RS15175	COG0861	Integral membrane protein TerC family
FED53_RS15240	COG0673	inositol 2-dehydrogenase activity
FED53_RS15255	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FED53_RS15260	COG1082	Xylose isomerase domain protein TIM barrel
FED53_RS15265	COG1063	alcohol dehydrogenase
FED53_RS15270	COG1082	Xylose isomerase domain protein TIM barrel
FED53_RS15285	COG1063	alcohol dehydrogenase
FED53_RS15290	COG1082	Xylose isomerase domain protein TIM barrel
FED53_RS15295	COG0673	inositol 2-dehydrogenase activity
FED53_RS15300	COG1172	Belongs to the binding-protein-dependent transport system permease family
FED53_RS15305	COG1129	ABC transporter
FED53_RS15315	COG1609	Transcriptional regulator
FED53_RS15325	COG3275	phosphorelay sensor kinase activity
FED53_RS15330	COG4753	response regulator
FED53_RS15330	COG2207	Transcriptional regulator
FED53_RS15355	COG5444	nuclease activity
FED53_RS15415	COG5444	nuclease activity
FED53_RS15545	COG5444	nuclease activity
FED53_RS15560	COG1959	2 iron, 2 sulfur cluster binding
FED53_RS15565	COG0702	epimerase
FED53_RS15575	COG5577	PFAM Coat F domain
FED53_RS15580	COG1063	alcohol dehydrogenase
FED53_RS15590	COG5577	PFAM Coat F domain
FED53_RS15600	COG0860	N-Acetylmuramoyl-L-alanine amidase
FED53_RS15630	COG0489	protein tyrosine kinase activity
FED53_RS15635	COG3944	biosynthesis protein
FED53_RS15645	COG1216	Glycosyl transferase, family 2
FED53_RS15660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FED53_RS15670	COG1181	Belongs to the D-alanine--D-alanine ligase family
FED53_RS15675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FED53_RS15680	COG1086	Polysaccharide biosynthesis protein
FED53_RS15685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FED53_RS15690	COG4464	protein tyrosine phosphatase activity
FED53_RS15715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FED53_RS15740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FED53_RS15745	COG1309	transcriptional regulator
FED53_RS15755	COG0840	transmembrane signaling receptor activity
FED53_RS15760	COG0791	NLP P60 protein
FED53_RS15775	COG3447	MASE1 domain protein
FED53_RS15775	COG5002	protein histidine kinase activity
FED53_RS15775	COG5001	Diguanylate cyclase
FED53_RS15780	COG1472	Belongs to the glycosyl hydrolase 3 family
FED53_RS15785	COG4640	response to antibiotic
FED53_RS15795	COG4640	response to antibiotic
FED53_RS15815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FED53_RS15820	COG4842	Belongs to the WXG100 family
FED53_RS15825	COG0753	catalase activity
FED53_RS15855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FED53_RS15860	COG3300	MHYT domain
FED53_RS15860	COG5001	Diguanylate cyclase
FED53_RS15870	COG1131	(ABC) transporter
FED53_RS15875	COG1725	Transcriptional regulator
FED53_RS15890	COG3718	enzyme involved in inositol metabolism
FED53_RS15915	COG0673	inositol 2-dehydrogenase activity
FED53_RS15920	COG2814	Major facilitator Superfamily
FED53_RS15925	COG0673	inositol 2-dehydrogenase activity
FED53_RS15930	COG1609	Transcriptional regulator
FED53_RS15935	COG1879	ABC-type sugar transport system periplasmic component
FED53_RS15940	COG1172	Belongs to the binding-protein-dependent transport system permease family
FED53_RS15945	COG1129	ABC transporter
FED53_RS15970	COG0154	amidase activity
FED53_RS15990	COG0492	ferredoxin-NADP+ reductase activity
FED53_RS16005	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FED53_RS16010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FED53_RS16020	COG0628	permease
FED53_RS16085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FED53_RS16110	COG0673	inositol 2-dehydrogenase activity
FED53_RS16130	COG1278	Cold shock
FED53_RS16135	COG0402	S-adenosylhomocysteine deaminase activity
FED53_RS16140	COG0778	Nitroreductase
FED53_RS16155	COG1272	protein, Hemolysin III
FED53_RS16165	COG0701	Predicted permease
FED53_RS16180	COG1984	allophanate hydrolase subunit 2
FED53_RS16185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FED53_RS16190	COG2188	Transcriptional regulator
FED53_RS16195	COG0366	Alpha amylase catalytic
FED53_RS16200	COG1263	PTS System
FED53_RS16200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FED53_RS16205	COG0697	spore germination
FED53_RS16215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FED53_RS16220	COG2252	PERMEase
FED53_RS16225	COG0402	S-adenosylhomocysteine deaminase activity
FED53_RS16245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FED53_RS16255	COG0406	alpha-ribazole phosphatase activity
FED53_RS16260	COG0716	FMN binding
FED53_RS16280	COG2205	protein histidine kinase activity
FED53_RS16280	COG0784	Response regulator, receiver
FED53_RS16310	COG3584	3D domain protein
FED53_RS16310	COG3583	domain protein
FED53_RS16315	COG1879	ABC-type sugar transport system periplasmic component
FED53_RS16320	COG1172	Belongs to the binding-protein-dependent transport system permease family
FED53_RS16325	COG1129	ABC transporter
FED53_RS16330	COG1869	D-ribose catabolic process
FED53_RS16335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FED53_RS16340	COG1609	Transcriptional regulator
FED53_RS16345	COG0656	L-ascorbic acid biosynthetic process
FED53_RS16350	COG1414	Transcriptional regulator
FED53_RS16370	COG3162	membrane
FED53_RS16375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FED53_RS16390	COG1733	regulation of RNA biosynthetic process
FED53_RS16395	COG1511	domain protein
FED53_RS16400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FED53_RS16405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FED53_RS16410	COG1116	anion transmembrane transporter activity
FED53_RS16415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FED53_RS16420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FED53_RS16425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FED53_RS16435	COG2226	methyltransferase
FED53_RS16440	COG3180	Ammonia monooxygenase
FED53_RS16445	COG0583	DNA-binding transcription factor activity
FED53_RS16450	COG3181	Tripartite tricarboxylate transporter family receptor
FED53_RS16455	COG4565	transcriptional regulatory protein
FED53_RS16460	COG3290	protein histidine kinase activity
FED53_RS16465	COG2851	Citrate transporter
FED53_RS16485	COG3290	protein histidine kinase activity
FED53_RS16490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FED53_RS16495	COG1301	dicarboxylic acid transport
FED53_RS16510	COG3773	Cell wall hydrolase
FED53_RS16525	COG0577	efflux transmembrane transporter activity
FED53_RS16530	COG1136	(ABC) transporter
FED53_RS16535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FED53_RS16550	COG1607	acyl-coa hydrolase
FED53_RS16560	COG4297	protein containing double-stranded beta helix domain
FED53_RS16565	COG2814	Major facilitator Superfamily
FED53_RS16570	COG1733	regulation of RNA biosynthetic process
FED53_RS16575	COG4895	conserved protein (DUF2196)
FED53_RS16580	COG0584	glycerophosphoryl diester phosphodiesterase
FED53_RS16585	COG1620	l-lactate permease
FED53_RS16590	COG0179	Fumarylacetoacetate (FAA) hydrolase
FED53_RS16595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FED53_RS16600	COG0277	FAD linked oxidase domain protein
FED53_RS16605	COG0247	lactate metabolic process
FED53_RS16610	COG0277	FAD linked oxidase domain protein
FED53_RS16615	COG2186	Transcriptional regulator
FED53_RS16620	COG0735	belongs to the Fur family
FED53_RS16630	COG1595	DNA-templated transcription, initiation
FED53_RS16650	COG0697	spore germination
FED53_RS16655	COG1802	Transcriptional regulator
FED53_RS16660	COG1366	Belongs to the anti-sigma-factor antagonist family
FED53_RS16660	COG2202	Pas domain
FED53_RS16670	COG2116	formate transmembrane transporter activity
FED53_RS16680	COG2146	nitrite reductase [NAD(P)H] activity
FED53_RS16685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FED53_RS16690	COG0803	Belongs to the bacterial solute-binding protein 9 family
FED53_RS16695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FED53_RS16700	COG1121	(ABC) transporter
FED53_RS16730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FED53_RS16740	COG2211	Major facilitator Superfamily
FED53_RS16750	COG0523	cobalamin synthesis protein
FED53_RS16760	COG2226	methyltransferase
FED53_RS16765	COG1181	Belongs to the D-alanine--D-alanine ligase family
FED53_RS16800	COG3209	COG3209 Rhs family protein
FED53_RS16810	COG0823	Involved in the tonB-independent uptake of proteins
FED53_RS16810	COG1506	peptidase
FED53_RS16810	COG4946	Tricorn protease homolog
FED53_RS16815	COG0662	Cupin 2, conserved barrel domain protein
FED53_RS16845	COG1683	Conserved Protein
FED53_RS16855	COG1063	alcohol dehydrogenase
FED53_RS16905	COG0210	DNA helicase
FED53_RS16935	COG2003	Belongs to the UPF0758 family
FED53_RS16985	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FED53_RS17000	COG1070	Carbohydrate kinase
FED53_RS17005	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FED53_RS17010	COG1737	Transcriptional regulator
FED53_RS17025	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FED53_RS17035	COG2382	esterase
FED53_RS17045	COG2153	protein acetylation
FED53_RS17060	COG2323	membrane
FED53_RS17070	COG0210	DNA helicase
FED53_RS17120	COG0475	glutathione-regulated potassium exporter activity
FED53_RS17120	COG0569	domain protein
FED53_RS17125	COG2239	Acts as a magnesium transporter
FED53_RS17130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FED53_RS17135	COG0564	pseudouridine synthase activity
FED53_RS17145	COG2357	RelA SpoT domain protein
FED53_RS17155	COG4116	CYTH
FED53_RS17160	COG0741	lytic transglycosylase activity
FED53_RS17165	COG2346	COG2346, Truncated hemoglobins
FED53_RS17170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FED53_RS17175	COG1164	Oligoendopeptidase f
FED53_RS17185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FED53_RS17195	COG0861	Integral membrane protein TerC family
FED53_RS17200	COG1393	Belongs to the ArsC family
FED53_RS17205	COG1566	PFAM secretion protein HlyD family protein
FED53_RS17215	COG0456	acetyltransferase
FED53_RS17220	COG4608	Belongs to the ABC transporter superfamily
FED53_RS17225	COG0444	Belongs to the ABC transporter superfamily
FED53_RS17230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FED53_RS17235	COG0601	transmembrane transport
FED53_RS17240	COG4166	transmembrane transport
FED53_RS17245	COG0180	Tryptophanyl-tRNA synthetase
FED53_RS17255	COG5504	Zn-dependent protease
FED53_RS17260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FED53_RS17265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FED53_RS17285	COG2267	carboxylic ester hydrolase activity
FED53_RS17295	COG1874	Beta-galactosidase
FED53_RS17300	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
FED53_RS17305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FED53_RS17310	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FED53_RS17325	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FED53_RS17330	COG0542	response to heat
FED53_RS17350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FED53_RS17360	COG0505	Belongs to the CarA family
FED53_RS17370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FED53_RS17375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FED53_RS17380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FED53_RS17385	COG2151	metal-sulfur cluster biosynthetic enzyme
FED53_RS17395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FED53_RS17400	COG1307	EDD domain protein, DegV family
FED53_RS17410	COG2996	Protein conserved in bacteria
FED53_RS17415	COG1666	GTP binding
FED53_RS17420	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS17425	COG3829	transcription factor binding
FED53_RS17430	COG4187	Peptidase family M20/M25/M40
FED53_RS17435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FED53_RS17440	COG1012	belongs to the aldehyde dehydrogenase family
FED53_RS17445	COG1609	Transcriptional regulator
FED53_RS17450	COG0366	Alpha amylase catalytic
FED53_RS17455	COG0004	ammonium transporteR
FED53_RS17460	COG0347	Belongs to the P(II) protein family
FED53_RS17470	COG0367	asparagine synthase
FED53_RS17515	COG1403	HNH endonuclease
FED53_RS17520	COG0419	ATPase involved in DNA repair
FED53_RS17525	COG0420	3'-5' exonuclease activity
FED53_RS17530	COG1074	ATP-dependent DNA helicase activity
FED53_RS17535	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FED53_RS17540	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS17545	COG0398	Pfam SNARE associated Golgi protein
FED53_RS17615	COG2224	Isocitrate lyase
FED53_RS17620	COG0501	Belongs to the peptidase M48B family
FED53_RS17625	COG1024	Enoyl-CoA hydratase
FED53_RS17630	COG0318	PFAM AMP-dependent synthetase and ligase
FED53_RS17635	COG0095	Lipoate-protein ligase
FED53_RS17640	COG1234	tRNA 3'-trailer cleavage
FED53_RS17655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FED53_RS17660	COG2207	Transcriptional regulator
FED53_RS17665	COG2972	Histidine kinase
FED53_RS17675	COG0768	penicillin binding
FED53_RS17680	COG1309	transcriptional regulator
FED53_RS17685	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FED53_RS17690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FED53_RS17695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FED53_RS17700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FED53_RS17705	COG2329	Antibiotic biosynthesis monooxygenase
FED53_RS17710	COG3069	C4-dicarboxylate transmembrane transporter activity
FED53_RS17720	COG1473	amidohydrolase
FED53_RS17730	COG4473	ABC transporter
FED53_RS17735	COG1131	(ABC) transporter
FED53_RS17740	COG0537	adenosine 5'-monophosphoramidase activity
FED53_RS17745	COG2153	protein acetylation
FED53_RS17750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FED53_RS17765	COG1846	Transcriptional regulator
FED53_RS17790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FED53_RS17800	COG3481	metal-dependent phosphohydrolase, HD sub domain
FED53_RS17805	COG1668	transmembrane transport
FED53_RS17810	COG4152	abc transporter atp-binding protein
FED53_RS17825	COG1024	Enoyl-CoA hydratase
FED53_RS17830	COG0318	PFAM AMP-dependent synthetase and ligase
FED53_RS17835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FED53_RS17840	COG0561	phosphatase activity
FED53_RS17850	COG1131	(ABC) transporter
FED53_RS17860	COG3679	Belongs to the UPF0342 family
FED53_RS17865	COG4399	Belongs to the UPF0754 family
FED53_RS17870	COG0189	ligase activity
FED53_RS17875	COG0189	ligase activity
FED53_RS17880	COG0189	ligase activity
FED53_RS17885	COG0189	ligase activity
FED53_RS17895	COG2508	Transcriptional regulator
FED53_RS17900	COG3842	ATPase activity
FED53_RS17915	COG1253	flavin adenine dinucleotide binding
FED53_RS17920	COG0702	epimerase
FED53_RS17925	COG0351	phosphomethylpyrimidine kinase
FED53_RS17930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FED53_RS17935	COG2022	thiamine diphosphate biosynthetic process
FED53_RS17945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FED53_RS17950	COG0352	thiamine-phosphate diphosphorylase activity
FED53_RS17960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FED53_RS17965	COG0765	amino acid transport
FED53_RS17970	COG1126	abc transporter atp-binding protein
FED53_RS17975	COG0604	alcohol dehydrogenase
FED53_RS17980	COG2719	SpoVR family
FED53_RS17990	COG1268	BioY protein
FED53_RS17995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FED53_RS18000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FED53_RS18005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FED53_RS18010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FED53_RS18015	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FED53_RS18020	COG3153	acetyltransferase
FED53_RS18020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FED53_RS18030	COG0564	pseudouridine synthase activity
FED53_RS18040	COG0840	transmembrane signaling receptor activity
FED53_RS18045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FED53_RS18050	COG0584	glycerophosphoryl diester phosphodiesterase
FED53_RS18070	COG3842	ATPase activity
FED53_RS18075	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FED53_RS18085	COG3290	protein histidine kinase activity
FED53_RS18085	COG3829	transcription factor binding
FED53_RS18090	COG2610	gluconate transmembrane transporter activity
FED53_RS18095	COG2217	Heavy metal translocating P-type atpase
FED53_RS18100	COG0586	Pfam SNARE associated Golgi protein
FED53_RS18105	COG0628	permease
FED53_RS18110	COG1301	dicarboxylic acid transport
FED53_RS18115	COG1968	undecaprenyl-diphosphatase activity
FED53_RS18120	COG1114	Component of the transport system for branched-chain amino acids
FED53_RS18130	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FED53_RS18145	COG0697	spore germination
FED53_RS18150	COG0688	phosphatidylethanolamine metabolic process
FED53_RS18160	COG1846	Transcriptional regulator
FED53_RS18165	COG2718	Belongs to the UPF0229 family
FED53_RS18170	COG2766	serine protein kinase
FED53_RS18175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FED53_RS18190	COG3382	B3 4 domain protein
FED53_RS18200	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FED53_RS18310	COG0735	belongs to the Fur family
FED53_RS18315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FED53_RS18335	COG4555	ABC transporter
FED53_RS18340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FED53_RS18345	COG4129	membrane
FED53_RS18355	COG1132	(ABC) transporter
FED53_RS18375	COG1028	Short-chain dehydrogenase reductase Sdr
FED53_RS18385	COG1194	a g-specific adenine glycosylase
FED53_RS18390	COG1988	membrane-bound metal-dependent
FED53_RS18410	COG0300	oxidoreductase activity
FED53_RS18415	COG2137	regulation of response to DNA damage stimulus
FED53_RS18440	COG1090	epimerase
FED53_RS18465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FED53_RS18475	COG0840	transmembrane signaling receptor activity
FED53_RS18480	COG0778	Nitroreductase
FED53_RS18490	COG1280	lysine exporter protein (LysE YggA)
FED53_RS18495	COG0778	Nitroreductase
FED53_RS18510	COG0745	RESPONSE REGULATOR receiver
FED53_RS18515	COG5002	protein histidine kinase activity
FED53_RS18520	COG0577	efflux transmembrane transporter activity
FED53_RS18525	COG1136	(ABC) transporter
FED53_RS18530	COG1113	amino acid transport
FED53_RS18555	COG1126	abc transporter atp-binding protein
FED53_RS18560	COG0765	amino acid transport
FED53_RS18570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FED53_RS18585	COG1695	Transcriptional regulator
FED53_RS18620	COG1131	(ABC) transporter
FED53_RS18645	COG3279	Response regulator of the LytR AlgR family
FED53_RS18655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FED53_RS18660	COG2079	MmgE PrpD family protein
FED53_RS18665	COG0372	Belongs to the citrate synthase family
FED53_RS18685	COG0494	nUDIX hydrolase
FED53_RS18705	COG0300	oxidoreductase activity
FED53_RS18710	COG0693	protein deglycase activity
FED53_RS18720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FED53_RS18730	COG0640	Transcriptional regulator
FED53_RS18735	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FED53_RS18750	COG0386	Belongs to the glutathione peroxidase family
FED53_RS18755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FED53_RS18770	COG1309	transcriptional regulator
FED53_RS18780	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FED53_RS18795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FED53_RS18800	COG0697	spore germination
FED53_RS18805	COG2207	Transcriptional regulator
FED53_RS18805	COG0662	Cupin 2, conserved barrel domain protein
FED53_RS18810	COG1929	Belongs to the glycerate kinase type-1 family
FED53_RS18815	COG2610	gluconate transmembrane transporter activity
FED53_RS18820	COG3835	regulator
FED53_RS18825	COG0583	DNA-binding transcription factor activity
FED53_RS18830	COG2814	Major facilitator Superfamily
FED53_RS18840	COG3655	Transcriptional regulator
FED53_RS18850	COG1253	flavin adenine dinucleotide binding
FED53_RS18875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FED53_RS18900	COG0535	radical SAM domain protein
FED53_RS18910	COG0387	Pfam Sodium calcium exchanger
FED53_RS18915	COG3871	stress protein (general stress protein 26)
FED53_RS18960	COG0477	Major facilitator Superfamily
FED53_RS18970	COG0640	Transcriptional regulator
FED53_RS18980	COG2217	Heavy metal translocating P-type atpase
FED53_RS18985	COG1295	ribonuclease BN
FED53_RS18990	COG4980	gas vesicle protein
FED53_RS18995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FED53_RS19000	COG4840	Belongs to the UPF0435 family
FED53_RS19005	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FED53_RS19010	COG2340	Cysteine-rich secretory protein family
FED53_RS19020	COG0693	protein deglycase activity
FED53_RS19025	COG1115	amino acid carrier protein
FED53_RS19035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FED53_RS19035	COG1017	nitric oxide dioxygenase activity
FED53_RS19040	COG1959	2 iron, 2 sulfur cluster binding
FED53_RS19045	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
FED53_RS19055	COG0488	(ABC) transporter
FED53_RS19070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FED53_RS19080	COG2356	endonuclease I
FED53_RS19095	COG1511	domain protein
FED53_RS19100	COG0433	COG0433 Predicted ATPase
FED53_RS19100	COG1674	ftsk spoiiie
FED53_RS19105	COG4499	WXG100 protein secretion system (Wss), protein YukC
FED53_RS19110	COG5417	Belongs to the EsaB family
FED53_RS19115	COG4842	Belongs to the WXG100 family
FED53_RS19135	COG0513	Belongs to the DEAD box helicase family
FED53_RS19150	COG2311	Membrane
FED53_RS19155	COG3852	Histidine kinase
FED53_RS19160	COG3290	protein histidine kinase activity
FED53_RS19165	COG0598	Magnesium transport protein CorA
FED53_RS19175	COG1115	amino acid carrier protein
FED53_RS19190	COG0693	protein deglycase activity
FED53_RS19195	COG0745	RESPONSE REGULATOR receiver
FED53_RS19200	COG5002	protein histidine kinase activity
FED53_RS19200	COG3850	Histidine kinase
FED53_RS19215	COG1876	peptidase activity
FED53_RS19225	COG2070	2-Nitropropane dioxygenase
FED53_RS19230	COG2706	6-phosphogluconolactonase activity
FED53_RS19235	COG0024	Methionine aminopeptidase
FED53_RS19240	COG3852	Histidine kinase
FED53_RS19245	COG1744	ABC transporter substrate-binding protein PnrA-like
FED53_RS19250	COG0166	Belongs to the GPI family
FED53_RS19255	COG1187	pseudouridine synthase activity
FED53_RS19260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FED53_RS19265	COG0581	inorganic phosphate transmembrane transporter activity
FED53_RS19270	COG0573	inorganic phosphate transmembrane transporter activity
FED53_RS19275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FED53_RS19285	COG1597	lipid kinase activity
FED53_RS19295	COG0154	amidase activity
FED53_RS19300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FED53_RS19310	COG4851	CamS sex pheromone cAM373 precursor
FED53_RS19315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FED53_RS19320	COG0210	DNA helicase
FED53_RS19325	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FED53_RS19330	COG0423	glycine-tRNA ligase activity
FED53_RS19335	COG4496	protein, YerC YecD
FED53_RS19340	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FED53_RS19350	COG0151	Belongs to the GarS family
FED53_RS19355	COG0138	bifunctional purine biosynthesis protein purh
FED53_RS19360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FED53_RS19365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FED53_RS19370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FED53_RS19375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FED53_RS19380	COG0047	phosphoribosylformylglycinamidine synthase activity
FED53_RS19385	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FED53_RS19390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FED53_RS19395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FED53_RS19400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FED53_RS19405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FED53_RS19430	COG2252	PERMEase
FED53_RS19435	COG0519	Catalyzes the synthesis of GMP from XMP
FED53_RS19435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FED53_RS19440	COG1305	Transglutaminase-like
FED53_RS19445	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
FED53_RS19450	COG0714	Associated with various cellular activities
FED53_RS19460	COG1733	regulation of RNA biosynthetic process
FED53_RS19470	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FED53_RS19475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FED53_RS19485	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FED53_RS19495	COG0300	oxidoreductase activity
FED53_RS19515	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FED53_RS19520	COG1266	CAAX protease self-immunity
FED53_RS19530	COG0805	protein transport
FED53_RS19535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FED53_RS19540	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FED53_RS19545	COG0488	(ABC) transporter
FED53_RS19555	COG0456	acetyltransferase
FED53_RS19560	COG1214	PFAM Peptidase M22, glycoprotease
FED53_RS19565	COG0802	atpase or kinase
FED53_RS19660	COG2183	response to ionizing radiation
FED53_RS19665	COG2208	phosphoserine phosphatase activity
FED53_RS19670	COG1191	sigma factor activity
FED53_RS19680	COG1366	Belongs to the anti-sigma-factor antagonist family
FED53_RS19685	COG2208	phosphoserine phosphatase activity
FED53_RS19690	COG2172	sigma factor antagonist activity
FED53_RS19695	COG1366	Belongs to the anti-sigma-factor antagonist family
FED53_RS19700	COG1366	Belongs to the anti-sigma-factor antagonist family
FED53_RS19705	COG2337	Toxic component of a toxin-antitoxin (TA) module
FED53_RS19710	COG0864	Transcriptional regulator
FED53_RS19715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FED53_RS19720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FED53_RS19725	COG0736	holo-[acyl-carrier-protein] synthase activity
FED53_RS19730	COG0705	Rhomboid family
FED53_RS19735	COG4294	response to UV
FED53_RS19740	COG0513	Belongs to the DEAD box helicase family
FED53_RS19745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FED53_RS19750	COG1181	Belongs to the D-alanine--D-alanine ligase family
FED53_RS19760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FED53_RS19775	COG3842	ATPase activity
FED53_RS19785	COG3527	Alpha-acetolactate decarboxylase
FED53_RS19795	COG0246	Mannitol dehydrogenase
FED53_RS19800	COG3711	transcriptional antiterminator
FED53_RS19805	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FED53_RS19805	COG2213	PTS system mannitol-specific
FED53_RS19815	COG1556	Lactate utilization protein
FED53_RS19820	COG1139	Iron-sulfur cluster binding protein
FED53_RS19825	COG0247	lactate metabolic process
FED53_RS19830	COG2186	Transcriptional regulator
FED53_RS19835	COG1620	l-lactate permease
FED53_RS19855	COG3620	sequence-specific DNA binding
FED53_RS19860	COG0534	Mate efflux family protein
FED53_RS19870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FED53_RS19875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FED53_RS19880	COG4856	YbbR-like protein
FED53_RS19885	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FED53_RS19890	COG5662	AntiSigma factor
FED53_RS19895	COG1595	DNA-templated transcription, initiation
FED53_RS19970	COG0726	polysaccharide deacetylase
FED53_RS19975	COG2194	sulfuric ester hydrolase activity
FED53_RS19985	COG0489	protein tyrosine kinase activity
FED53_RS19990	COG0860	N-Acetylmuramoyl-L-alanine amidase
FED53_RS20005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FED53_RS20010	COG0101	tRNA pseudouridine synthase activity
FED53_RS20015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FED53_RS20020	COG1122	ATPase activity
FED53_RS20025	COG1122	ATPase activity
FED53_RS20030	COG0203	ribosomal protein L17
FED53_RS20035	COG0202	RNA polymerase activity
FED53_RS20040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FED53_RS20045	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FED53_RS20050	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FED53_RS20055	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FED53_RS20060	COG0024	Methionine aminopeptidase
FED53_RS20065	COG0563	adenylate kinase activity
FED53_RS20070	COG0201	protein transport
FED53_RS20075	COG0200	Binds to the 23S rRNA
FED53_RS20080	COG1841	ribosomal large subunit assembly
FED53_RS20085	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FED53_RS20105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FED53_RS20115	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FED53_RS20120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FED53_RS20125	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FED53_RS20135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FED53_RS20140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FED53_RS20145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FED53_RS20155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FED53_RS20160	COG0089	rRNA binding
FED53_RS20165	COG0088	Forms part of the polypeptide exit tunnel
FED53_RS20170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FED53_RS20180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FED53_RS20190	COG0049	tRNA binding
FED53_RS20195	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FED53_RS20200	COG1358	cellular component organization or biogenesis
FED53_RS20210	COG0085	RNA polymerase activity
FED53_RS20215	COG2813	Specifically methylates the guanine in position
FED53_RS20220	COG0222	ribosome binding
FED53_RS20225	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FED53_RS20230	COG0081	regulation of translation
FED53_RS20235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FED53_RS20240	COG0250	Participates in transcription elongation, termination and antitermination
FED53_RS20245	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FED53_RS20250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FED53_RS20260	COG3688	RNA-binding protein containing a PIN domain
FED53_RS20265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FED53_RS20275	COG0215	cysteine-tRNA ligase activity
FED53_RS20280	COG1045	serine acetyltransferase
FED53_RS20285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FED53_RS20290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FED53_RS20295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FED53_RS20300	COG4956	integral membrane protein (PIN domain superfamily)
FED53_RS20305	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FED53_RS20310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FED53_RS20315	COG0542	response to heat
FED53_RS20320	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FED53_RS20325	COG3880	PFAM UvrB UvrC protein
FED53_RS20350	COG1523	belongs to the glycosyl hydrolase 13 family
FED53_RS20355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FED53_RS20360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FED53_RS20365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FED53_RS20370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FED53_RS20375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FED53_RS20380	COG0512	Glutamine amidotransferase of anthranilate synthase
FED53_RS20385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FED53_RS20390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FED53_RS20395	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FED53_RS20400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FED53_RS20405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FED53_RS20410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FED53_RS20420	COG0515	serine threonine protein kinase
FED53_RS20425	COG2304	oxidoreductase activity
FED53_RS20445	COG1098	S1 RNA binding domain
FED53_RS20450	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FED53_RS20465	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FED53_RS20470	COG3956	TIGRFAM MazG family protein
FED53_RS20475	COG2244	polysaccharide biosynthetic process
FED53_RS20480	COG2002	toxin-antitoxin pair type II binding
FED53_RS20485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FED53_RS20500	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FED53_RS20510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FED53_RS20515	COG2088	sporulation resulting in formation of a cellular spore
FED53_RS20520	COG0251	oxidation-reduction process
FED53_RS20525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FED53_RS20540	COG4466	Protein conserved in bacteria
FED53_RS20550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FED53_RS20560	COG0084	hydrolase, TatD family'
FED53_RS20565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FED53_RS20565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FED53_RS20570	COG2002	toxin-antitoxin pair type II binding
FED53_RS20575	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FED53_RS20585	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FED53_RS20590	COG4467	Involved in initiation control of chromosome replication
FED53_RS20595	COG1774	PSP1 C-terminal conserved region
FED53_RS20600	COG0470	DNA polymerase III
FED53_RS20605	COG3870	Protein conserved in bacteria
FED53_RS20610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FED53_RS20615	COG1982	Orn Lys Arg decarboxylase major